Sample records for regulation supplement acquisition
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2013-11-15
... DFARS 252.232-7007, Limitation of Government's Obligation. DFARS subpart 232.7, Contract [[Page 68830...; Defense Federal Acquisition Regulation Supplement; Contract Financing AGENCY: Defense Acquisition... and OMB Number: Defense Federal Acquisition Regulation Supplement (DFARS) Part 232, Contract Financing...
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75 FR 3178 - Defense Federal Acquisition Regulation Supplement; Lead System Integrators
2010-01-20
... Government procurement. Amy G. Williams, Editor, Defense Acquisition Regulations System. 0 Accordingly, the..., without change, an interim rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to... limitations on the award of new contracts for lead system integrator functions in the acquisition of major DoD...
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2010-06-11
... Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS Case 2009-D025) AGENCY: Defense.../Pension Review from Procedures, Guidance, and Information to the Defense Acquisition Regulation Supplement..., February 23, 2006, moved requirements for Contractor Insurance/Pension Review (CIPR) from DFARS 242.7302 to...
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2010-08-27
...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Interim rule; delay in... rule that amended the Defense Federal Acquisition Regulation Supplement (DFARS) to implement sections... comments on the interim rule were located, which had not been addressed in finalization of the interim rule...
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77 FR 2680 - Defense Federal Acquisition Regulation Supplement; Definition of Cost or Pricing Data
2012-01-19
... Regulation Supplement; Definition of Cost or Pricing Data AGENCY: Defense Acquisition Regulations System... Acquisition Regulation Supplement (DFARS) to update text addressing the definition of cost or pricing data... update the DFARS for consistency with FAR changes addressing the definition of cost or pricing data...
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2010-10-25
... Accounting Service or Missile Defense Agency. (2) For DoD, the authority to acknowledge receipt or reject... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 219 and 252 [DFARS Case 2009-D002] Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting...
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2013-10-24
... Relating to Organizational Conflict of Interest-Major Defense Acquisition Program; OMB Control Number 0704...] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Organizational Conflict... submit comments, identified by OMB Control Number 0704-0477, using any of the following methods: [cir...
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2011-11-18
... Government procurement. Mary Overstreet, Editor, Defense Acquisition Regulations System. Interim Rule Adopted... Federal Acquisition Regulation Supplement: Management of Manufacturing Risk in Major Defense Acquisition...). ACTION: Final rule. SUMMARY: DoD is adopting as final, without change, an interim rule amending the...
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2010-12-03
..., et al. Defense Federal Acquisition Regulation Supplement; Business Systems-- Definition and... Regulation Supplement; Business Systems--Definition and Administration (DFARS Case 2009-D038) AGENCY: Defense.... SUPPLEMENTARY INFORMATION: I. Background DoD published a proposed rule for Business Systems--Definition and...
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2012-01-30
... Federal Acquisition Regulation Supplement; Independent Research and Development Technical Descriptions... Regulation Supplement (DFARS) to require major contractors to report independent research and development (IR... 11414 on March 2, 2011, to revise requirements for reporting IR&D projects to the Defense Technical...
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2011-11-18
... all small business concerns. In combination with the change to the regulations, DoD immediately began... Federal Acquisition Regulation Supplement: Accelerate Small Business Payments (DFARS Case 2011-D008... Regulation Supplement to accelerate payments to all small business concerns. DATES: Effective Date: November...
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2010-04-08
...-AG35 Defense Federal Acquisition Regulation Supplement; Minimizing Use of Hexavalent Chromium (DFARS... Regulation Supplement (DFARS) to address requirements for minimizing the use of hexavalent chromium in... of items containing hexavalent chromium under DoD contracts unless an exception applies. DATES...
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2013-08-08
...-AI02 Defense Federal Acquisition Regulation Supplement: Clauses With Alternates--Contract Financing... Supplement (DFARS) to create an overarching prescription for the set of contract financing related clauses... amend the DFARS to create an overarching prescription for the contract financing clause with one...
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2011-03-17
... Federal Acquisition Regulation Supplement; Nonavailability Exception for Procurement of Hand or Measuring... Subjects in 48 CFR Part 225 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition... requirement at 10 U.S.C. 2533a (Berry Amendment) to acquire only domestic hand or measuring tools. DATES...
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2010-11-24
... also asked what allowance is provided for contractors with accounting software that does not... RIN 0750-AG46 Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting... Regulation Supplement (DFARS) to address DoD Cost and Software Data Reporting system requirements for Major...
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2013-03-28
... Federal Acquisition Regulation Supplement: New Free Trade Agreement With Colombia (DFARS Case 2012-D032... Regulation Supplement (DFARS) to implement the United States-Colombia Trade Promotion Agreement. This Trade Promotion Agreement is a free trade agreement that provides for mutually non-discriminatory treatment of...
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2011-09-27
..., 215, 216, and 252 RIN 0750-AH11 Defense Federal Acquisition Regulation Supplement; Only One Offer... Supplement (DFARS) to address acquisitions using competitive procedures in which only one offer is received... days, if the solicitation allowed fewer than 30 days for receipt of proposals and only one offer is...
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2013-10-31
... Federal Acquisition Regulation Supplement: Private Sector Notification Requirements of In-Sourcing Actions... Supplement (DFARS) to implement a section of the National Defense Authorization Act regarding private sector... section 938 of the National Defense Authorization Act (NDAA) for Fiscal Year 2012 regarding private sector...
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2013-09-30
...-AH97 Defense Federal Acquisition Regulation Supplement: Enhancement of Contractor Employee... contractor and subcontractor employees. DATES: Effective date: September 30, 2013. In accordance with FAR 1... Whistleblower Protections for Contractor Employees) made extensive changes to 10 U.S.C. 2409, entitled...
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76 FR 75875 - Defense Federal Acquisition Regulation Supplement; Open Source Software Public Meeting
2011-12-05
... Regulation Supplement; Open Source Software Public Meeting AGENCY: Defense Acquisition Regulations System... initiate a dialogue with industry regarding the use of open source software in DoD contracts. DATES: Public... to the risks to the contractors and the Government associated with using open source software on DoD...
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2011-09-16
...] RIN 0750-AH15 Defense Federal Acquisition Regulation Supplement; Increase the Use of Fixed-Price...-price incentive (firm target) contracts, with particular attention to share lines and ceiling prices... the use of fixed-price incentive (firm target) contracts, especially for acquisitions moving from...
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77 FR 2682 - Defense Federal Acquisition Regulation Supplement; DoD Voucher Processing
2012-01-19
... provisional payment and sent to the disbursing office after a pre- payment review. Interim vouchers not... after a pre-payment review. Interim vouchers not selected for a pre-payment review will be considered to...] RIN 0750-AH52 Defense Federal Acquisition Regulation Supplement; DoD Voucher Processing AGENCY...
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2011-09-20
... Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Services Performance... performance evaluations for construction and architect-engineer services. DATES: Effective Date: September 20... past performance for construction and Architect- Engineer services. On April 19, 2011, DoD published a...
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2012-02-24
...D published an initial proposed rule for Business Systems-- Definition and Administration (DFARS... the definition and administration of contractor business systems as follows: A. Contractor business..., 245, and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems...
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2010-10-29
...-AG52 Defense Federal Acquisition Regulation Supplement (DFARS); Continuation of Essential Contractor... that contractors providing essential contractor services, as determined by the requiring activity..., implementing the requirements of DoDI 3020.37, Continuation of Essential DoD Contractor Services During Crises...
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2010-11-24
... Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS Case 2009-D025... conducting a Contractor Insurance/Pension Review from Procedures, Guidance, and Information (PGI) to the... This final rule relocates requirements for Contractor Insurance/ Pension Review to DFARS 242.7302 from...
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2011-05-18
...; Business Systems-- Definition and Administration; Interim Rule #0;#0;Federal Register / Vol. 76 , No. 96...-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration... an initial proposed rule for Business Systems-- Definition and Administration (DFARS Case 2009-D038...
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2013-05-22
... Number 0750-AG38 Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access... Government support contractors to have access to proprietary technical data belonging to prime contractors and other third parties, provided that the technical data owner may require the support contractor to...
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2011-03-02
... Acquisition Regulation Supplement; Independent Research and Development Technical Descriptions (DFARS Case... (DFARS) to require contractors to report independent research and development (IR&D) projects generating... to the Defense Technical Information Center (DTIC). Beginning in the 1990s, DoD reduced its technical...
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2011-03-17
... makes it unlikely that a small business could afford to sustain the infrastructure required to perform...-AG73 Defense Federal Acquisition Regulation Supplement; Safety of Facilities, Infrastructure, and... facilities, infrastructure, and equipment that are intended for use by military or civilian personnel of the...
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2010-12-09
..., and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition... for Business Systems--Definition and Administration (DFARS Case 2009-D038) in the Federal Register on... improve the effectiveness of DoD oversight of contractor business systems. The comment period is being...
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2011-09-20
... acceptance point and replacing it with more specific data entries for inspection, acceptance, and ship to Do..., acceptance, and ship-to fields but kept the source, destination, and other inspection and acceptance points... Acquisition Regulation Supplement; Material Inspection and Receiving Report (DFARS Case 2009-D023) AGENCY...
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2010-10-29
... Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption for Commercial... Balance of Payments Program for construction material that is commercial information technology. DATES... the Balance of Payments Program for commercial information technology to be used in overseas...
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2011-02-22
... Federal Acquisition Regulation Supplement; Repeal of the Small Business Competitiveness Demonstration... the Small Business Competitiveness Demonstration Program. DATES: Effective Date: February 22, 2011...-656) by striking title VII (15 U.S.C. 644 note). The repeal of the Small Business Competitiveness...
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2011-07-25
...-AG88 Defense Federal Acquisition Regulation Supplement; Prohibition on Interrogation of Detainees by... prescribes policies prohibiting interrogation of detainees by contractor personnel, as required by section... ancillary positions, including as trainers of, and advisors to, interrogations, if the contractor personnel...
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2012-03-12
... Federal Acquisition Regulation Supplement: Alleged Crimes By or Against Contractor Personnel (DFARS Case... (DFARS) to expand coverage on contractor requirements and responsibilities relating to alleged crimes by or against contractor personnel. DATES: Comment Date: Comments on the proposed rule should be...
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2012-02-24
...DoD is issuing a final rule amending the Defense Federal Acquisition Regulation Supplement to extend the program period for the DoD Test Program for Negotiation of Comprehensive Small Business Subcontracting Plans.
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2011-11-21
... 0750-AH39 Defense Federal Acquisition Regulation Supplement: Applicability of Hexavalent Chromium... the use of materials containing hexavalent chromium. DATES: Comment Date: Comments on the proposed... human health and environmental risks related to the use of hexavalent chromium. Hexavalent chromium is a...
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2011-03-17
...-AH18 Defense Federal Acquisition Regulation Supplement; Repeal of Restriction on Ballistic Missile...). Section 222 repeals the restriction on purchase of Ballistic Missile Defense research, development, test... Ballistic Missile Defense research, development, test, and evaluation that was required by section 222 of...
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2010-11-03
...-AG88 Defense Federal Acquisition Regulation Supplement; Prohibition on Interrogation of Detainees by... National Defense Authorization Act for Fiscal Year 2010 (Pub. L. 111-84) prohibits the interrogation of..., to add DFARS 237.173, Prohibition on Interrogation of Detainees by Contractor Personnel, adding a...
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2011-06-29
... Federal Acquisition Regulation Supplement; Successor Entities to the Netherlands Antilles (DFARS Case 2011... ``designated country'' due to the change in the political status of the islands that comprised the Netherlands..., 2010, Curacao and Sint Maarten became autonomous territories of the Kingdom of the Netherlands. Bonaire...
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2011-09-16
... the title of the applicable Department of Homeland Security (DHS) fraud hotline poster and Web site(s... General Fraud Hotline Posters AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... Regulation Supplement (DFARS) to require contractors to display the DoD fraud hotline poster in common work...
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2010-01-20
...-AG31 Defense Federal Acquisition Regulation Supplement; Trade Agreements--Costa Rica and Peru (DFARS... respect to Costa Rica, and the United States-Peru Trade Promotion Agreement. The trade agreements waive... States Free Trade Agreement with respect to Costa Rica and the United States-Peru Trade Promotion...
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2011-06-29
... Sexual Assault/Harassment Involving DoD Contractors During Contingency Operations,'' dated April 16, 2010... Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY... employees accompanying U.S. Armed Forces are made aware of the DoD definition of sexual assault as defined...
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2010-09-27
...-AG30 Defense Federal Acquisition Regulation Supplement; Motor Carrier Fuel Surcharge (DFARS Case 2008... comments is provided below: 1. Comment. One respondent stated that it is customary in the motor carrier freight industry to assume a fixed cost of diesel fuel with a cost recovery mechanism (fuel surcharge) for...
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2010-11-30
... Inspector General audit D-2010-052, entitled ``Efforts to Prevent Sexual Assault/Harassment Involving DoD... Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY: Defense..., to ensure contractor employees are aware of the DoD definition of ``sexual assault'' as defined in Do...
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2011-03-11
..., Washington, DC 22202-2884. (ii) Department of Homeland Security (DHS) fraud hotline poster identified in... _________ _________ _________ _________ (Contracting Officer shall insert-- (i) Title of applicable Department of Homeland Security fraud hotline...-AG98 Defense Federal Acquisition Regulation Supplement; Display of DoD Inspector General Fraud Hotline...
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2010-11-24
... mentoring, teaching, training, advice, and recommendations to senior military officers, staff, and students... Acquisition Regulation Supplement; Services of Senior Mentors (DFARS Case 2010-D025) AGENCY: Defense... policy on the services of senior mentors. DATES: Effective: November 24, 2010. FOR FURTHER INFORMATION...
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2010-09-08
...-AG50 Defense Federal Acquisition Regulation Supplement; Government Rights in the Design of DoD Vessels.... Section 825 clarifies the Government's rights in technical data in the designs of a DoD vessel, boat... cite DFARS Case 2008-D039. SUPPLEMENTARY INFORMATION: A. Background This final rule implements section...
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2010-09-08
...., because the changes are to internal Government organization and operating procedures only. The rule... 48 CFR Part 207 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations... Life Cycle of Major Defense Acquisition Programs (DFARS Case 2009-D014) AGENCY: Defense Acquisition...
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76 FR 13297 - Defense Federal Acquisition Regulation Supplement; Technical Amendments
2011-03-11
... 215 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System... Director, Defense Procurement and Acquisition Policy. DATES: Effective Date: March 11, 2011. Applicability... adding a section at 215.300 with a reference to Director, Defense Procurement and Acquisition Policy...
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77 FR 13013 - Defense Federal Acquisition Regulation Supplement; Technical Amendments
2012-03-05
... Organization Government Procurement Agreement and the Free Trade Agreements, as determined by the United States... 252 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System...
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2012-04-05
... commercial items, that includes the clause at 252.225-7001, Buy American Act and Balance of Payments Program... Acquisitions of Commercial Items AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... acquisition of commercial items and to specify flowdown of clauses to commercial subcontracts. DATES: Comments...
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2012-12-31
... Security Cooperation Agency, the Defense Security Service, the Defense Threat Reduction Agency, the Missile... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 202 RIN 0750-AH81 Defense...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is...
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2010-06-15
... Conflicts of Interest in Major Defense Acquisition Programs AGENCY: Defense Acquisition Regulations System... extended an additional 30 days to provide additional time for interested parties to review the proposed... interested parties to review the proposed DFARS changes. Ynette R. Shelkin, Editor, Defense Acquisition...
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2013-11-22
... and Procedures AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION... proposed information collection; (c) ways to enhance the quality, utility, and clarity of the information..., withhold, or withdraw purchasing system approval at the conclusion of a purchasing system review...
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2010-06-11
... Certain Contracts with Foreign Entities for the Conduct of Ballistic Missile Defense Research, Development..., development, test, or evaluation in connection with the Ballistic Missile Defense Program. The provision... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0229...
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2013-04-05
... Identification Advance Shipment Notices AGENCY: Defense Acquisition Regulations System, Department of Defense (Do...) Whether the proposed collection of information is necessary for the proper performance of the functions of... at 252.211; Radio Frequency Identification Advance Shipment Notices, OMB Control Number 0704-0434...
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2013-03-13
... automated collection techniques or other forms of information technology. The Office of Management and... construction contract in Spain has adequate insurance coverage. Affected Public: Businesses or other for profit... construction contract in Spain. Kortnee Stewart, Editor, Defense Acquisition Regulations System. [FR Doc. 2013...
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2010-05-12
... Control Number 0704-0253) AGENCY: Defense Acquisition Regulations System, Department of Defense. ACTION... proposed information collection; (c) ways to enhance the quality, utility, and clarity of the information..., withhold, or withdraw purchasing system approval at the conclusion of a purchasing system review...
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48 CFR Appendix - Federal Acquisition Regulation (FAR) Index
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Federal Acquisition Regulation (FAR) Index Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT... (IFMS) Contract clause. FAR Index Federal Acquisition Regulation (FAR) Index Editorial Note: This...
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2013-06-17
... and for foreign firms in their supply chains. The U.S. concluded the DTC Treaties with Australia and... respondent commended the Defense Acquisition Regulations (DAR) Council on recognizing the importance of the... established a Management Board to resolve such issues, adopted a detailed management plan, and conducted...
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2012-05-22
... arrangement, the Government would take title to the devices during contract performance or at the conclusion... rule will promote utilization of domestic photovoltaic devices, even when the Government does not take... Devices (DFARS Case 2011-D046) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD...
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2011-05-05
... officials to specify e-mail as an ``electronic commerce method'' so long as it is authorized in the schedule... recognized electronic commerce method. The respondent recommended, in the alternative, that the Government... stated that electronic commerce is a term specifically identified in Federal Acquisition Regulation (FAR...
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2012-06-29
... market research/industry communication. In 2008, the Office of Management and Budget and Office of... unique or brand name specifications, and enhancing acquisition planning. In 2010, the Government... strategic defense capabilities, because of a shift to ``lowest price possible.'' Further, according to this...
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2013-11-18
... payroll, finance, logistics, and personnel management applications; or (2) Is protected at all times by... recommendation from the Under Secretary of Defense for Acquisition, Technology, and Logistics (USD(AT&L)) and the... assess all costs and benefits of available regulatory alternatives and, if regulation is necessary, to...
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Supplemental knowledge acquisition through external product interface for CLIPS
Saito, Tim; Ebaud, Stephen; Loftin, Bowen R.
1990-01-01
Traditionally, the acquisition of knowledge for expert systems consisted of the interview process with the domain or subject matter expert (SME), observation of domain environment, and information gathering and research which constituted a direct form of knowledge acquisition (KA). The knowledge engineer would be responsible for accumulating pertinent information and/or knowledge from the SME(s) for input into the appropriate expert system development tool. The direct KA process may (or may not) have included forms of data or documentation to incorporate from the SME's surroundings. The differentiation between direct KA and supplemental KA (indirect) would be the difference in the use of data. In acquiring supplemental knowledge, the knowledge engineer would access other types of evidence (manuals, documents, data files, spreadsheets, etc.) that would support the reasoning or premises of the SME. When an expert makes a decision in a particular task, one tool that may have been used to justify a recommendation, would have been a spreadsheet total or column figure. Locating specific decision points from that data within the SME's framework would constitute supplemental KA. Data used for a specific purpose in one system or environment would be used as supplemental knowledge for another, specifically a CLIPS project.
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2013-02-28
... Contractor Personnel AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION... (FY) 2009 and expand coverage on contractor requirements and responsibilities relating to alleged crimes by or against contractor personnel. DATES: Effective February 28, 2013. FOR FURTHER INFORMATION...
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48 CFR 252.231-7000 - Supplemental cost principles.
2010-10-01
... principles. 252.231-7000 Section 252.231-7000 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.231-7000 Supplemental cost principles. As prescribed in 231.100-70, use the following clause: Supplemental Cost Principles (DEC 1991) When the allowability of costs under...
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2010-06-08
... procurement memorandum of understanding (RDP MOU) between the government of Finland and the Government of the United States has been in effect since 1991. The governments have negotiated and concluded a new RDP MOU... Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System. 0 Therefore, 48...
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2012-08-28
... multi-agency contracts, or basic ordering agreements. The proposed text also directs that a... agreements, or blanket purchase agreements. As a result of the proposed rule, new awards under the AbilityOne... Part 204 Government procurement. Manuel Quinones, Editor, Defense Acquisition Regulations System...
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2010-09-27
....203-13, Contractor Code of Business Ethics and Conduct. DATES: Effective Date: September 27, 2010. FOR... Acquisition Regulation (FAR) Case 2007-006, ``Contractor Business Ethics Compliance Program and Disclosure... date of December 12, 2008. The contract clause entitled ``Contractor Code of Business Ethics and...
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2012-12-31
... cost or pricing data'' in its place. PART 217--SPECIAL CONTRACTING METHODS 217.7401 [Amended] 0 11... Cost or Pricing Data (DFARS Case 2011-D040) AGENCY: Defense Acquisition Regulations System, Department... ``certified cost or pricing data'' and ``data other than certified cost or pricing data.'' The DFARS changes...
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78 FR 35195 - Acquisition Regulations: Export Control
2013-06-12
... DEPARTMENT OF ENERGY 48 CFR Parts 925, 952, and 970 RIN 1991-AB99 Acquisition Regulations: Export... Energy (DOE) is proposing to amend the Department of Energy Acquisition Regulation (DEAR) to add export... comments, identified by ``DEAR: Export Control and RIN 1991-AB99,'' by any of the following methods...
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78 FR 45168 - Acquisition Regulations: Export Control
2013-07-26
... DEPARTMENT OF ENERGY 48 CFR Parts 925, 952 and 970 RIN 1991-AB99 Acquisition Regulations: Export... (78 FR 35195) to amend the Department of Energy Acquisition Regulation (DEAR) to add export control... ``DEAR: Export Control and RIN 1991-AB99,'' by any of the following methods: Federal eRulemaking Portal...
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75 FR 60261 - Federal Acquisition Regulation; Award-Fee Language Revision
2010-09-29
...-AL42 Federal Acquisition Regulation; Award-Fee Language Revision AGENCIES: Department of Defense (DoD...: Final rule. SUMMARY: The Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) have adopted as final, with changes, the interim rule amending the Federal Acquisition...
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2011-06-06
..., eligibility of Peruvian end products under trade agreements, and participation of foreign contractors in... contractors in acquisitions in support of operations in Afghanistan, and eligibility of Peruvian end products....225-7045, Balance of Payments Program--Construction Material Under Trade Agreements. This final rule...
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48 CFR 752.231-71 - Salary supplements for HG employees.
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Salary supplements for HG....231-71 Salary supplements for HG employees. As prescribed in 731.205-71, for use in all contracts with... sub-contracts. Salary Supplements for HG Employees (OCT 1998) (a) Salary supplements are payments made...
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2010-12-29
... prescriptions. Amends 225.1101(6)(i) to reference the World Trade Organization (WTO) Government Procurement... Subjects in 48 CFR Parts 225 and 252 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition... paragraph (c)(iii) to read as follows: 225.403 World Trade Organization Government Procurement Agreement and...
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75 FR 14057 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-40; Introduction
2010-03-23
... the Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) in..., consider all the information in FAPIIS and PPIRS when making a responsibility determination, and notify the... appropriate for the official's consideration; and Enter a non-responsibility determination into FAPIIS. The...
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75 FR 53127 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-45; Introduction
2010-08-30
... summarizes the Federal Acquisition Regulation (FAR) rules agreed to by the Civilian Agency Acquisition... Chambers. Cost or Pricing Data. III American Recovery 2009-008 Davis. and Reinvestment Act of 2009 (the Recovery Act)-- Buy American Requirements for Construction Materials. SUPPLEMENTARY INFORMATION: Summaries...
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Problems and Prospects: Public Health Regulation of Dietary Supplements.
Binns, Colin W; Lee, Mi Kyung; Lee, Andy H
2018-04-01
Dietary supplements are a global business worth more than US$100 billion annually. These supplements are taken by up to 50% of adults and perhaps one-third of children in economically advanced economies. Definitions of dietary supplements differ from country to country, and regulation is generally lax and often seems to be directed more toward promoting commerce than protecting public health. Supplements may directly cause toxic reactions or may interact with other supplements or pharmaceuticals. Some supplements are found to have been contaminated with heavy metals, and others do not contain the expected quantities of active ingredients. In general, supplements are not needed except in cases of established deficiencies, and excess of some nutrients can increase cancer rates. There are important public health reasons for taking some supplements, including folate and iodine in pregnancy. This review discusses the public health concerns associated with dietary supplements and suggests directions for further regulation.
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48 CFR 731.205-71 - Salary supplements for Host Government employees.
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Salary supplements for... Contracts With Commercial Organizations 731.205-71 Salary supplements for Host Government employees. (a... fifty percent of its financial support from the government. (b) General. Salary supplement occurs when...
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Should states and local governments regulate dietary supplements?
Starr, Ranjani
2016-01-01
Federal regulation of dietary supplements in the United States is governed by the Dietary Supplement Health and Education Act of 1994. The law has been criticized as weak and ineffective. Alarming research has emerged demonstrating that supplements may be mislabelled, contaminated, adulterated with dangerous or unknown compounds, or sold at toxic doses. As a result, the health community has raised concerns about the safety and quality of dietary supplements. Increased federal oversight is an important avenue for improving supplement safety; however, states and local governments may also pursue strategies to strengthen the overall regulatory control of dietary supplements. States and local governments have substantial experience in regulating other products that pose a risk to public health, such as tobacco. Additionally, much has been learned about the tactics the tobacco industry has employed to protect its interests. Lessons learned may be applied to new regulatory efforts aimed at improving the safety of dietary supplements at the state and local levels. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.
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2012-08-29
... and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance of... Acquisition of Right-Hand Drive Passenger Sedans (DFARS Case 2012-D016) AGENCY: Defense Acquisition... of the statutory dollar limitation on the acquisition of right-hand drive passenger sedans. DATES...
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75 FR 10567 - Commerce Acquisition Regulation (CAR)
2010-03-08
... regulations, Federal acquisition regulations, Government procurement, Government contracts, Procurement, Reporting and recordkeeping requirements. 48 CFR Part 1302 Definitions, Government procurement, Terms. 48 CFR Part 1303 Antitrust, Conflict of interests, Ethical conduct, Government procurement, Reporting and...
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2012-03-30
... and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance of... Acquisition of Right-Hand Drive Passenger Sedans (DFARS Case 2012-D016) AGENCY: Defense Acquisition... acquisition of right-hand drive passenger sedans be included on the list of dollar thresholds subject to...
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2012-09-24
... automated collection techniques or other forms of information technology. The Office of Management and... 252.232-7002, Progress Payments for Foreign Military Sales Acquisitions; OMB Control Number 0704-0321.... The clause at 252.232- 7002, Progress Payments for Foreign Military Sales Acquisitions, requires each...
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76 FR 3536 - Defense Federal Acquisition Regulation Supplement; Technical Amendments
2011-01-20
... concerns, HUBZone small business concerns, small disadvantaged business concerns, women-owned small... date, and revising paragraph (a)(10) to read as follows: 252.225-7009 Restriction on Acqusition of Certain Articles Containing Specialty Metals. * * * * * RESTRICTION ON ACQUISITION OF CERTAIN ARTICLES...
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2011-11-02
... Acquisition Circular 2005-54; Small Entity Compliance Guide AGENCY: Department of Defense (DoD), General... Federal Acquisition Circular (FAC) 2005-54, which amend the Federal Acquisition Regulation (FAR... (FAR Case 2009-006) This final rule amends the FAR to implement Executive Order (E.O.) 13494, Economy...
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2010-04-13
... Acquisition Circular 2005-41; Small Entity Compliance Guide AGENCIES: Department of Defense (DoD), General... Federal Acquisition Circular (FAC) 2005-41 which amends the Federal Acquisition Regulation (FAR... projects where the total cost to the Government is $25 million or more in order to promote economy and...
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78 FR 46781 - Federal Acquisition Regulation; Definition of Contingency Operation
2013-08-01
... Federal Acquisition Regulation; Definition of Contingency Operation AGENCY: Department of Defense (DoD... the Federal Acquisition Regulation (FAR) to revise the definition of ``contingency operation'' to... ``contingency operation'' at FAR 2.101 in accordance with the statutory change to the definition made by...
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76 FR 14572 - Federal Acquisition Regulation; Technical Amendments
2011-03-16
... Acquisition Regulations. List of Subjects in 48 CFR Parts 18, 19, and 52 Government procurement. Dated: March... in paragraph (b) by removing ``http:// www.whitehouse.gov/omb/procurement/guides/emergency_acquisitions_ guide.pdf'' and adding ``http://www.whitehouse.gov/sites/default/files/ omb/assets/procurement...
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75 FR 14496 - Commerce Acquisition Regulation (CAR); Correction
2010-03-26
... DEPARTMENT OF COMMERCE 48 CFR Part 1352 [Document Number: 080730954-0129-03] RIN 0605-AA26 Commerce Acquisition Regulation (CAR); Correction AGENCY: Department of Commerce (DOC). ACTION: Final rule; correction. SUMMARY: We, the Department of Commerce, issue a final rule to bring the Commerce Acquisition...
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77 FR 51496 - Federal Acquisition Regulation; Basic Safeguarding of Contractor Information Systems
2012-08-24
... Federal Acquisition Regulation; Basic Safeguarding of Contractor Information Systems AGENCY: Department of... Acquisition Regulation (FAR) to add a new subpart and contract clause for the basic safeguarding of contractor... information) that will be resident on or transiting through contractor information systems. DATES: Interested...
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77 FR 27550 - Federal Acquisition Regulation; Revision of Cost Accounting Standards Threshold
2012-05-10
...] RIN 9000-AM25 Federal Acquisition Regulation; Revision of Cost Accounting Standards Threshold AGENCY... Federal Acquisition Regulation (FAR) to revise the threshold for applicability of cost accounting standards in order to implement a recent rule of the Cost Accounting Standards Board and statutory...
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DEFF Research Database (Denmark)
Liu, Tao; Li, Yingjun; Wang, Xiaodi
2015-01-01
Acquisition of de novo spacer sequences confers CRISPR-Cas with a memory to defend against invading genetic elements. However, the mechanism of regulation of CRISPR spacer acquisition remains unknown. Here we examine the transcriptional regulation of the conserved spacer acquisition genes in Type I......, it was demonstrated that the transcription level of csa1, cas1, cas2 and cas4 was significantly enhanced in a csa3a-overexpression strain and, moreover, the Csa1 and Cas1 protein levels were increased in this strain. Furthermore, we demonstrated the hyperactive uptake of unique spacers within both CRISPR loci...... in the presence of the csa3a overexpression vector. The spacer acquisition process is dependent on the CCN PAM sequence and protospacer selection is random and non-directional. These results suggested a regulation mechanism of CRISPR spacer acquisition where a single transcriptional regulator senses the presence...
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2011-02-16
... Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References AGENCIES... Acquisition Regulation (FAR) to update references to authoritative accounting standards owing to the Financial... Accounting Principles (GAAP) (``Codification of GAAP''). DATES: Interested parties should submit written...
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The history of efforts to regulate dietary supplements in the USA.
Swann, John P
2016-01-01
This review examines the emergence of dietary supplements and how the Food and Drug Administration (FDA) attempted to regulate these, beginning with the arrival of vitamins and how these were managed under the 1906 Food and Drugs Act, and ending with the seismic influence of the 1994 Dietary Supplement Health and Education Act (DSHEA). Included are the impact of major laws, key court decisions, and the construction of the FDA's supplement actions and rules from the 1920s to the 1990s for products that were neither drugs nor typical foods. Stiff resistance to the regulations by supplement manufacturers, trade associations, politicians, and especially the public at large is an important part of this story. The paper closes with the passage of DSHEA and how it literally changed the definition and parameters of control of dietary supplements. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.
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2012-02-10
... Acquisition Regulation; Reinstatement of Coverage Pertaining to Final Payment Under Construction and Building... Administration Acquisition Regulation (GSAR) to restore guidance on the release of claims after completion of construction and building service contracts to ensure contractors are paid in accordance with their contract...
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2015-09-01
Applicable to NAVSUP NFCS (after NLL, 2015) ...................21 Table 3. DON SAP Policy Letters (after NLL, 2015...and Acquisition Policy ERP Enterprise Resource Planning FAR Federal Acquisition Regulation FLC Fleet Logistic Center GLS Global Logistics...DON SAP Policy Letters (after NLL, 2015) Policy Letter # Subject Date Issued Current? Y/N Comments SA12- 03R1 NAVSUP ENTERPRISE POLICY FOR
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2011-06-06
... statutes or executive orders applicable to defense acquisitions of commercial items. * * * * * CONTRACT... ACQUISITIONS OF COMMERCIAL ITEMS (DATE) * * * * * (b) * * * (5)(i)--------252.225-7001, Buy American Act and Balance of Payments Program (DATE) (41 U.S.C. chapter 83, E.O. 10582). * * * * * (11)(i)--------252.225...
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78 FR 29247 - Contractor Legal Management Requirements; Acquisition Regulations; Correction
2013-05-20
... DEPARTMENT OF ENERGY 48 CFR Part 952 RIN 1990-AA37 Contractor Legal Management Requirements; Acquisition Regulations; Correction AGENCY: Department of Energy. ACTION: Final rule; correction. SUMMARY: The... (78 FR 25795). In this document, DOE revised existing regulations covering contractor legal management...
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2010-05-07
... to track and trace property items throughout their lifecycle (in acquisition and logistics business... entities to which this rule will apply. DoD invites comments from small business concerns and other...
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Regulations for the safe transport of radioactive material. 1985 ed. Supplement 1988
International Nuclear Information System (INIS)
1988-01-01
A major revision of the Agency's Regulations for the Safe Transport of Radioactive Material, Safety Series No. 6, was undertaken during a period of several years, culminating in the publication of the 1985 Edition. In order to consider minor problems in the new edition, the Agency convened a panel of experts in January 1986. This panel recommended some amendments which were subsequently published as Supplement 1986 to the Regulations. A further review panel meeting took place in June 1987. The amendments which were recommended for early adoption were themselves divided into two kinds. The first of these are designated as minor changes. The second kind of amendment recommended for early adoption comprises actual changes to regulatory provisions. Several changes of this second type were recommended by the panel and are included in this Supplement. The Supplement also contains the amended texts of the supporting documents, Safety Series Nos 7, 37 and 80, which are necessary to correct minor errors as well as to provide complementary information for the changes introduced to the Regulations themselves. In addition, the Supplement embodies the contents of Supplement 1986, which is consequently superseded.
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78 FR 13765 - Federal Acquisition Regulation; Definition of Contingency Operation
2013-02-28
... Federal Acquisition Regulation; Definition of Contingency Operation AGENCY: Department of Defense (DoD... Regulation (FAR) to revise the definition of ``contingency operation'' to address the statutory change to the... ``contingency operation'' at FAR 2.101 in accordance with the statutory change to the definition made by...
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77 FR 3636 - Federal Acquisition Regulation; Brand-Name Specifications; Correction
2012-01-25
... 26] RIN 9000-AK55 Federal Acquisition Regulation; Brand-Name Specifications; Correction AGENCY... Regulation (FAR) to implement the Office of Management and Budget memoranda on brand-name specifications, FAR Case 2005-037, Brand-Name Specifications, which published in the Federal Register at 77 FR 189 on...
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2011-12-01
... Management; Agriculture Acquisition Regulation, Labor Law Violations AGENCY: Office of Procurement and... Agriculture Acquisition Regulation (the ``AGAR'') to add a new clause at subpart 422.70 entitled ``Labor Law... respects and follows the policies and laws regarding worker labor protections particularly as they [[Page...
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2012-02-06
... Management; Agriculture Acquisition Regulation, Labor Law Violations; Withdrawal AGENCY: Office of... Agriculture Acquisition Regulation at subpart 422.70 entitled ``Labor Law Violations'' that would have a contractor certify upon accepting a contract that it is in compliance with all applicable labor laws and that...
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2011-12-01
... Management; Agriculture Acquisition Regulation, Labor Law Violations AGENCY: Office of Procurement and... Acquisition Regulation (the ``AGAR'') to add a new clause at subpart 422.70 entitled ``Labor Law Violations... objectives, this proposed rule adds a subpart and clause entitled Labor Law Violations to the Agriculture...
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2011-03-16
..., Sequence 1] RIN 9000-AL78 Federal Acquisition Regulation; Proper Use and Management of Cost-Reimbursement... other than firm-fixed-price contracts (e.g., cost-reimbursement, time-and-material, and labor-hour...-reimbursement contracts and identifies the following three areas that the Defense Acquisition Regulation Council...
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78 FR 46783 - Federal Acquisition Regulation; Documenting Contractor Performance
2013-08-01
..., Sequence 1] RIN 9000-AM09 Federal Acquisition Regulation; Documenting Contractor Performance AGENCY... the Contractor Performance Assessment Reporting System (CPARS), the single Governmentwide past... Procurement Policy (OFPP) memorandum entitled ``Improving the Use of Contractor Performance Information...
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Directory of Open Access Journals (Sweden)
Baraniak Justyna
2016-12-01
Full Text Available Food supplements are concentrated sources of nutrients and/or other substances with a nutritional or physiological effect. However, they often contain herbal substances or their preparations. Food supplements belong to category of food and for that reason are regulated by food legislation. European Union regulations and directives established general directions for dietary supplements, dietetic food, which due to their special composition or manufacturing process are prepared for specific groups of people with special nutritional needs, and novel food/novel food ingredients to ensure product safety, suitability and appropriate consumer information.
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76 FR 37704 - Federal Acquisition Regulation; Documenting Contractor Performance
2011-06-28
... Federal Acquisition Regulation; Documenting Contractor Performance AGENCY: Department of Defense (DoD..., and to require all past performance information be entered into the Contractor Performance Assessment... Contractor Performance Information. These changes provide Governmentwide standardized evaluation factors and...
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An innovative model for regulating supplement products: Natural health products in Canada
International Nuclear Information System (INIS)
Nestmann, Earle R.; Harwood, Melody; Martyres, Stephanie
2006-01-01
On 1 January 2004, Health Canada officially added a new term to the global list of synonyms for dietary supplements: natural health products (NHP). Developed with the intent of providing Canadian consumers with ready access to NHP that are safe, effective, and of high quality, the Natural Health Products Regulations (the NHP regulations) are applicable to the sale, manufacture, packaging, labelling, importation, distribution, and storage of NHP, and are administered by the recently formed Natural Health Products Directorate (NHPD) within Health Canada. This paper provides an overview of the process for regulating supplement products in Canada
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77 FR 12913 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program
2012-03-02
... 2010-015; Item I; Docket 2010-0015, Sequence 1] RIN 9000-AL97 Federal Acquisition Regulation; Women... Regulation (FAR) to implement the Small Business Administration's regulations establishing the Women-Owned Small Business (WOSB) Program. This rule authorizes the restriction of competition for Federal contracts...
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2011-08-02
... of Federal Acquisition Regulation (FAR) Award Fee Language Revision AGENCY: National Aeronautics and... Acquisition Circular (FAC) 2005-46. DATES: Effective Date: August 2, 2011. FOR FURTHER INFORMATION CONTACT... on February 8, 2011 (76 FR 6696) implementing Federal Acquisition Circular (FAC) 2005-46 which...
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2010-10-29
... States, Guam, Puerto Rico, and the Virgin Islands. DFARS 246.270-2 provides for the rule to apply to each... determination by the Contracting Officer with the concurrence of the relevant Discipline Working Group. The Discipline Working Group is defined in the clause. Section 807 is applicable to contracts for the acquisition...
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2010-04-08
... Budget under 44 U.S.C. 3501, et seq. List of Subjects in 48 CFR Parts 234 and 235 Government procurement...). ACTION: Final rule. SUMMARY: DoD is adopting as final, without change, an interim rule that requires the Milestone Decision Authority (MDA) for a major defense acquisition program (MDAP) to select the contract...
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2010-11-24
... Deputy Under Secretary of Defense (Acquisition, Technology, and Logistics) to revise the DoD source... misunderstood requirements. DoD notes the potential disadvantages of this proposed change in increased time to...
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76 FR 6696 - NASA Implementation of Federal Acquisition Regulation (FAR) Award Fee Language Revision
2011-02-08
... of Federal Acquisition Regulation (FAR) Award Fee Language Revision AGENCY: National Aeronautics and... (NFS) to implement the FAR Award Fee revision issued in Federal Acquisition Circular (FAC) 2005-46.... Background Federal Acquisition Circular (FAC) 2005-46 significantly revised FAR Parts 16.305, 16.401, and 16...
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76 FR 39242 - Federal Acquisition Regulation; TINA Interest Calculations
2011-07-05
... pricing data. This rule replaces the term ``simple interest'' as the requirement for calculating interest...-AL73 Federal Acquisition Regulation; TINA Interest Calculations AGENCIES: Department of Defense (DoD... interest calculations be applied to Government overpayments as a result of defective cost or pricing data...
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77 FR 189 - Federal Acquisition Regulation; Brand-Name Specifications
2012-01-03
... 2006-0020, Sequence 26] RIN 9000-AK55 Federal Acquisition Regulation; Brand-Name Specifications... Management and Budget memoranda on brand-name specifications. DATES: Effective Date: February 2, 2012. FOR... brand- name specifications. Eight respondents submitted 32 comments in response to the interim rule. The...
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2011-05-31
... 9000-AL62 Federal Acquisition Regulation; Buy American Exemption for Commercial Information Technology... from the Buy American Act for acquisition of information technology that is a commercial item. DATES: Effective Date: May 31, 2011. FOR FURTHER INFORMATION CONTACT: Ms. Cecelia L. Davis, Procurement Analyst, at...
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2012-02-17
... Services Administration Acquisition Regulation; Information Collection; GSA Mentor-Prot[eacute]g[eacute... collection concerning the GSA Mentor-Prot[eacute]g[eacute] Program, General Service Administration...- 0286, GSA Mentor-Prot[eacute]g[eacute] Program by any of the following methods: Regulations.gov : http...
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77 FR 12930 - Federal Acquisition Regulation: Socioeconomic Program Parity
2012-03-02
... (SDVOSB) Program, or the Women-Owned Small Business (WOSB) Program. DATES: Effective Date: April 2, 2012...) Program (see subpart 19.14); or (iv) Women-Owned Small Business (WOSB) Program (see subpart 19.15). (3... amending the Federal Acquisition Regulation (FAR) to implement a section of the Small Business Jobs Act of...
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2013-03-28
... Agreement. The Republic of Korea is already party to the World Trade Organization Government Procurement...) Agreement on Government Procurement (GPA). Although the rule now opens up Government procurement to the... 48 CFR Parts 225 and 252 Government procurement. Kortnee Stewart, Editor, Defense Acquisition...
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2011-03-22
... contracts for the acquisition of non-personal health care services. It requires the bidder/offeror prior to... Acquisition Regulation Clause 52.207-3, Right of First Refusal of Employment. An agency may not conduct or...
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2013-02-28
... indirect cost is expressly unallowable under a cost principle in the FAR, or an executive agency supplement... economic, environmental, public health and safety effects, distributive impacts, and equity). E.O. 13563... have a significant economic impact on a substantial number of small entities within the meaning of the...
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2013-05-16
... Management Name Changes, Phase 1 Implementation (DFARS Case 2012- D053) AGENCY: Defense Acquisition... Excluded Parties Listing System (EPLS) databases into the System for Award Management (SAM) database. DATES... enacted in an effort to improve the management and promotion of electronic Government services and...
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2010-06-08
...-DoD agencies that are an element of the intelligence community. B. Discussion The National Security... elements of the Department of Homeland Security concerned with the analysis of intelligence information... for property and services in excess of the simplified acquisition threshold by certain non-DoD...
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2011-03-02
... the ``preservation and storage of unique tooling associated with the production of hardware for a... agrees with the concept to sustain capability and supportability to the extent needed under major weapons... tooling associated with the production of hardware for a major defense acquisition program. DoD thinks...
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2011-06-08
... traceability of items to a warranty will assist all members of the supply chain to manage risk appropriately. This traceability also leads to ensuring the Government receives the supplies purchased, reducing the... Acquisition, Technology and Logistics dated February 6, 2007, which required definition of the requirements to...
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Regulations applicable to plant food supplements and related products in the European Union.
Silano, Vittorio; Coppens, Patrick; Larrañaga-Guetaria, Ainhoa; Minghetti, Paola; Roth-Ehrang, René
2011-12-01
This paper deals with the current regulatory and legal settings of traditional plant food supplements and herbal medicinal products in the European Union (EU). Marketing of botanicals in foods and food supplements in the EU is subject to several provisions of food law, which cover aspects of safety, production, labelling and product composition, including the use of additives and maximum levels of contaminants and residues. However, due to limited harmonization at the EU level, specific national regulations adopted at a Member State level also apply and mutual recognition is the mechanism through which such products can be marketed in EU countries other than those of origin. Unlike food supplements, marketing of traditional herbal medicinal products is regulated by an ad hoc Directive (i.e. Directive 2004/24/EC) covering in detail all the relevant aspects of these products, including a facilitated registration procedure at national level. However, by distinguishing traditional herbal medicinal products from plant food supplements and establishing selective marketing modalities for these two product categories, the EU has been confronted with implementation difficulties for traditional herbal medicinal products and a lack of homogeneity in the regulatory approaches adopted in different EU Member States. In fact, currently the nature of the commercial botanical products made available to consumers as traditional medicinal products or food supplements, depends largely on the EU Member State under consideration as a consequence of how competent National Authorities and manufacturing companies interpret and apply current regulations rather than on the intrinsic properties of the botanical products and their constituents. When the EU approach is compared with approaches adopted in some non-European countries to regulate these product categories, major differences become evident.
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77 FR 29983 - Federal Acquisition Regulation; Information Collection; Subcontract Consent
2012-05-21
... performance of functions of the Federal Acquisition Regulation (FAR), and whether it will have practical... The objective of consent to subcontract, as discussed in FAR Part 44, is to evaluate the efficiency and effectiveness with which the contractor spends Government funds, and complies with Government...
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2011-11-18
... Defense Mentor-Prot[eacute]g[eacute] Pilot Program (DFARS Case 2011-D050) AGENCY: Defense Acquisition... applications under the DoD Mentor-Prot[eacute]g[eacute] Pilot Program for new mentor-prot[eacute]g[eacute] agreements and the date mentors may incur costs and/or receive credit towards fulfilling their small business...
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76 FR 63896 - Federal Acquisition Regulation; Privacy Training, 2010-013
2011-10-14
... should a breach occur; and (7) Any agency-specific privacy training requirements. (d) The contractor is... Acquisition Regulation; Privacy Training, 2010-013 AGENCY: Department of Defense (DoD), General Services... contractors to complete training that addresses the protection of privacy, in accordance with the Privacy Act...
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2013-10-31
... exclusions. In accordance with FAR 19.805-1, an acquisition offered to the SBA shall be awarded on the basis... certified cost or pricing data is covered in FAR 15.4 and associated clauses in 52.215, OMB clearance 9000... 15.4 and associated clauses in FAR 52.215, and in OMB clearance 9000-013, Cost or Pricing Data...
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2013-07-10
... DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Parts 5 and 15 Federal Acquisition Regulation; Publicizing Contract Actions; Contracting by Negotiation CFR Correction In Title 48 of the Code of Federal Regulations, Chapter 1 (Parts 1 to 51), revised as of October 1, 2012, on page 115, in...
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2013-12-06
... alternate, and to include in the regulation the full text of the alternate clause. DATES: Comment date... provide each alternate clause in full text in the regulation. The inclusion of the full text of the... from from the basic clause. Placing the alternate clause in full text in the regulation will clarify...
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75 FR 60258 - Federal Acquisition Regulation; Termination for Default Reporting
2010-09-29
..., Sequence 1] RIN 9000-AL45 Federal Acquisition Regulation; Termination for Default Reporting AGENCIES... terminations for cause or default and defective cost or pricing data, into the Past Performance Information... defective cost or pricing data and terminations for cause or default into the FAPIIS module of the PPIRS...
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2013-10-31
... Supplement (DFARS) to implement the United States--Panama Trade Promotion Agreement. This Trade Promotion...--Panama Trade Promotion Agreement. No respondents submitted public comments in response to the interim... effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance of quantifying both costs...
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48 CFR 1845.407 - Non-Government use of plant equipment. (NASA supplements paragraph (a)).
2010-10-01
... Use and Rental of Government Property 1845.407 Non-Government use of plant equipment. (NASA supplements paragraph (a)). For NASA, the coverage in FAR 45.407, applies to all equipment, not just plant... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Non-Government use of plant...
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2012-01-30
...: Australia FTA 77,494 7,777,000 Bahrain FTA 202,000 10,074,262 CAFTA-DR (Costa Rica, Dominican 77,494 7,777... 202,000 7,777,000 NAFTA: --Canada 25,000 10,074,262 --Mexico 77,494 10,074,262 Peru FTA 202,000 7,777... acquisitions of commercial items or components, when the estimated value equals or exceeds $25,000, but is less...
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76 FR 31416 - Federal Acquisition Regulation; Oversight of Contractor Ethics Programs
2011-05-31
...-AL92 Federal Acquisition Regulation; Oversight of Contractor Ethics Programs AGENCY: Department of... that contractors have implemented the mandatory contractor business ethics program requirements. DATES... to Improve DoD's Oversight of Contractor Ethics Programs. The ethics program requirement flows from...
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2011-06-06
... 52.203-13, Contractor Code of Business Ethics and Conduct. This final rule corrects two omissions in... Subjects in 48 CFR Parts 203 and 252 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition... clause 52.203-13, Contractor Code of Business Ethics and Conduct. * * * * * PART 252--SOLICITATION...
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Shigella Iron Acquisition Systems and their Regulation.
Wei, Yahan; Murphy, Erin R
2016-01-01
Survival of Shigella within the host is strictly dependent on the ability of the pathogen to acquire essential nutrients, such as iron. As an innate immune defense against invading pathogens, the level of bio-available iron within the human host is maintained at exceeding low levels, by sequestration of the element within heme and other host iron-binding compounds. In response to sequestration mediated iron limitation, Shigella produce multiple iron-uptake systems that each function to facilitate the utilization of a specific host-associated source of nutrient iron. As a mechanism to balance the essential need for iron and the toxicity of the element when in excess, the production of bacterial iron acquisition systems is tightly regulated by a variety of molecular mechanisms. This review summarizes the current state of knowledge on the iron-uptake systems produced by Shigella species, their distribution within the genus, and the molecular mechanisms that regulate their production.
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77 FR 44063 - Federal Acquisition Regulations; DARPA-New Mexico Tax Agreement
2012-07-26
... Federal Acquisition Regulation (FAR) to add the United States Defense Advanced Research Projects Agency... Mexico (NM). The DARPA-NM tax agreement eliminates the double taxation of Government cost-reimbursement... 2012- 019. SUPPLEMENTARY INFORMATION: I. Background On August 18, 2011, DARPA and the Taxation and...
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2010-10-29
... Trade Organization Government Procurement Agreement and the Free Trade Agreements, as determined by the... of Subjects in 48 CFR Part 225 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition...
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2012-11-16
.... 601, et seq. Although the rule now opens up Government procurement to the goods and services of Panama... Applicability of specified procurement procedures designed to ensure fairness in the acquisition of supplies and... as the WTO GPA threshold, no new clause alternates are required for the Balance of Payments Program...
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2012-02-24
... Defense Mentor-Prot[eacute]g[eacute] Pilot Program (DFARS Case 2012-D024) AGENCY: Defense Acquisition... applications under the DoD Mentor-Prot[eacute]g[eacute] Pilot Program for new mentor-prot[eacute]g[eacute] agreements and the date mentors may incur costs and/or receive credit towards fulfilling their small business...
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2011-06-15
... Acquisition Regulation; Implementation of Information Technology Security Provision AGENCY: Office of... information technology (IT) supplies, services and systems with security requirements. DATES: Effective Date... effective date that include information technology (IT) supplies, services and systems with security...
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2012-01-06
... Acquisition Regulation; Implementation of Information Technology Security Provision AGENCY: Office of... orders that include information technology (IT) supplies, services and systems. DATES: Effective Date... 6, 2012 that include information technology (IT) supplies, services and systems with security...
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2011-03-16
...] RIN 9000-AL58 Federal Acquisition Regulation; Disclosure and Consistency of Cost Accounting Practices... Regulation (FAR) to align it with a Cost Accounting Standards (CAS) Board clause, Disclosure and Consistency... the use of the clause, Disclosure and Consistency of Cost Accounting Practices--Foreign Concerns, in...
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2012-05-24
... Services Administration Acquisition Regulation; Submission for OMB Review; GSA Mentor-Prot[eacute]g[eacute... collection concerning the GSA Mentor-Prot[eacute]g[eacute] Program, General Service Administration... Collection 3090- 0286, GSA Mentor-Prot[eacute]g[eacute] Program by any of the following methods: Regulations...
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2010-12-08
... does not have enough market leverage for it to be in the business interest of the manufacturers and... reason for changing the rule is statutory change. 10 U.S.C. 2534(a)(5) is no longer in effect because... Government leverage with regard to acquisition of commercial bearings. The Government continues to issue more...
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2012-01-19
... following methods: [cir] Regulations.gov : http://www.regulations.gov . Submit comments via the Federal e... contract. In order to determine the sequence of modifications to a contract or order, a method for... the numeric order of the modifications to a contract is not the order in which the changes to the...
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2012-03-15
... Services Administration Acquisition Regulation; Information Collection; Price Reductions Clause; Extension... notice of request for comments regarding OMB Control No. 3090-0235, Price Reductions Clause, published in... 16, 2012. ADDRESSES: Submit comments identified by Information Collection 3090- 0235, Price...
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A two-component system regulates hemin acquisition in Porphyromonas gingivalis.
Directory of Open Access Journals (Sweden)
Jodie C Scott
Full Text Available Porphyromonas gingivalis is a Gram-negative oral anaerobe associated with infection of the periodontia. The organism has a small number of two-component signal transduction systems, and after comparing genome sequences of strains W83 and ATCC 33277 we discovered that the latter was mutant in histidine kinase (PGN_0752, while the cognate response regulator (PGN_0753 remained intact. Microarray-based transcriptional profiling and ChIP-seq assays were carried out with an ATCC 33277 transconjugant containing the functional histidine kinase from strain W83 (PG0719. The data showed that the regulon of this signal transduction system contained genes that were involved in hemin acquisition, including gingipains, at least three transport systems, as well as being self-regulated. Direct regulation by the response regulator was confirmed by electrophoretic mobility shift assays. In addition, the system appears to be activated by hemin and the regulator acts as both an activator and repressor.
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Lugasi, Andrea; Horacsek, Márta; Martos, Eva
2010-09-26
According to recent legislation, food supplements are foodstuffs with the purpose of supplementing normal diet. Food supplements are concentrated sources of nutrients such as vitamins and minerals and other substances with a physiological or nutritional effect. In Hungary, marketing of food supplements has not been bound to pre-market authorization since joining to the European Union. The food business operator, who is responsible for production or distribution of the product, must notify it at National Institute for Food and Nutrition Science latest at the time when the product has been placed on the market and it can be distributed simultaneously. Distribution, ingredients, and all those information which appear on the label are determined by numerous regulations and prescriptions but at the same time the lack of harmonized legislation at certain places may cause a lot of problems on Community level. The first part of the study shows the laws and regulations influencing the distribution and ingredients of food supplements, while the main target of the second part is to introduce the evaluation process of components from nutritional and physiological point of view, and the role played by the food supplements in nutrition.
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76 FR 68039 - Federal Acquisition Regulation; Successor Entities to the Netherlands Antilles
2011-11-02
...] RIN 9000-AM11 Federal Acquisition Regulation; Successor Entities to the Netherlands Antilles AGENCIES... ``designated country'' due to the change in status of the islands that comprised the Netherlands Antilles... 2011-014. SUPPLEMENTARY INFORMATION: I. Background The Netherlands Antilles was designated as a...
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77 FR 17352 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program
2012-03-26
...-AL97 Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program Correction In rule...) * * * -- (24) 52.219-29, Notice of Set-Aside for Economically Disadvantaged Women-Owned Small Business (EDWOSB... Disadvantaged Women- Owned Small Business Concerns. * * * * * Notice of Set-Aside for Economically Disadvantaged...
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75 FR 82575 - Federal Acquisition Regulation; Personal Identity Verification of Contractor Personnel
2010-12-30
... 9000-AL60 Federal Acquisition Regulation; Personal Identity Verification of Contractor Personnel AGENCY... requirement of collecting from contractors all forms of Government-provided identification once they are no...D Inspector General Audit Report No. D-2009-005, entitled ``Controls Over the Contractor Common...
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2011-01-14
... contracts for the acquisition of non-personal health care services. It requires the bidder/offeror prior to... Regulation clause 52.207-3, Right of First Refusal of Employment. Affected Public: Business or other for...
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75 FR 34282 - Federal Acquisition Regulation; FAR Case 2009-013, Nonavailable Articles
2010-06-16
...-AL40 Federal Acquisition Regulation; FAR Case 2009-013, Nonavailable Articles AGENCIES: Department of... revise the list of articles determined to be domestically nonavailable. DATES: Effective Date: July 16.... SUPPLEMENTARY INFORMATION: A. Background The Buy American Act does not apply with respect to articles, materials...
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Directory of Open Access Journals (Sweden)
João A.B. Pedroso
2015-05-01
Full Text Available Leucine is a well-known activator of the mammalian target of rapamycin (mTOR. Because mTOR signaling regulates several aspects of metabolism, the potential of leucine as a dietary supplement for treating obesity and diabetes mellitus has been investigated. The objective of the present review was to summarize and discuss the available evidence regarding the mechanisms and the effects of leucine supplementation on the regulation of food intake, energy balance, and glucose homeostasis. Based on the available evidence, we conclude that although central leucine injection decreases food intake, this effect is not well reproduced when leucine is provided as a dietary supplement. Consequently, no robust evidence indicates that oral leucine supplementation significantly affects food intake, although several studies have shown that leucine supplementation may help to decrease body adiposity in specific conditions. However, more studies are necessary to assess the effects of leucine supplementation in already-obese subjects. Finally, although several studies have found that leucine supplementation improves glucose homeostasis, the underlying mechanisms involved in these potential beneficial effects remain unknown and may be partially dependent on weight loss.
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2010-01-28
... Acquisition Regulation; Submission for OMB Review; Industrial Funding Fee and Sales Reporting AGENCY... Management and Budget (OMB) a request to review and approve a reinstatement of a previously approved information collection requirement regarding industrial [[Page 4566
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2012-01-03
... 9000-AM00 Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting... accounting standards owing to the Financial Accounting Standards Board's Accounting Standards Codification of Generally Accepted Accounting Principles. DATES: Effective Date: February 2, 2012. FOR FURTHER INFORMATION...
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75 FR 38675 - Federal Acquisition Regulation; FAR Case 2008-011, Government Property
2010-07-02
... contractor to use the property on an independent research and development (IR&D) program rent free, if-- (a... Government for all property acquired or fabricated by the Contractor in accordance with the financing...-0029; Sequence 1] RIN 9000-AL41 Federal Acquisition Regulation; FAR Case 2008-011, Government Property...
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48 CFR 434.004 - Acquisition strategy.
2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Acquisition strategy. 434.004 Section 434.004 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION General 434.004 Acquisition strategy. (a) The program...
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48 CFR 873.105 - Acquisition planning.
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquisition planning. 873.105 Section 873.105 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS DEPARTMENT... planning. (a) Acquisition planning is an indispensable component of the total acquisition process. (b) For...
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48 CFR 3034.004 - Acquisition strategy.
2010-10-01
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Acquisition strategy. 3034.004 Section 3034.004 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND... Acquisition strategy. See (HSAR) 48 CFR 3009.570 for policy applicable to acquisition strategies that consider...
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2011-11-21
..., using any of the following methods: [cir] Regulations.gov : http://www.regulations.gov . Submit comments... Training 252.209-7003, Reserve Officer Corps and Military Recruiting on Training Corps and Military Campus. Recruiting on Campus-- Representation. 252.216-7000, Economic Price 252.216-70XX, Economic Price Adjustment...
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2013-05-09
... Services Administration Acquisition Regulation; Submission for OMB Review; Industrial Funding Fee and Sales... Budget (OMB) a request to review and approve a reinstatement of a previously approved information collection requirement regarding industrial funding fee and sales reporting. A notice was published in the...
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78 FR 37692 - Federal Acquisition Regulation; Contracting With Women-Owned Small Business Concerns
2013-06-21
...-AM59 Federal Acquisition Regulation; Contracting With Women-Owned Small Business Concerns AGENCY... disadvantaged women-owned small business concerns and to women-owned small business concerns eligible under the Women-owned Small Business Program. DATES: Effective Date: June 21, 2013. Comment Date: Interested...
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2013-09-30
... 9000-AM56 Federal Acquisition Regulation; Pilot Program for Enhancement of Contractor Employee... program enhancing whistleblower protections for contractor employees. DATES: Effective: September 30, 2013... contractor employees at FAR subpart 3.9. The pilot program is mandated by section 828, entitled ``Pilot...
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2012-09-20
...] General Services Administration Acquisition Regulation; Submission for OMB Review; Price Reductions Clause... requirement regarding the GSAR Price Reductions Clause. A notice was published in the Federal Register at 76... identified by Information Collection 3090- 0235, Price Reduction Clause, by any of the following methods...
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48 CFR 970.2301 - Sustainable acquisition.
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Sustainable acquisition. 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY..., Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition...
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2011-11-29
... Federal Acquisition Regulation; Updates to Contract Reporting and Central Contractor Registration AGENCIES... Procurement Data System (FPDS). Additionally, changes are proposed for the clauses requiring contractor registration in the Central Contractor Registration (CCR) database and DUNS number reporting. DATES: Interested...
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Data acquisition techniques using PC
Austerlitz, Howard
1991-01-01
Data Acquisition Techniques Using Personal Computers contains all the information required by a technical professional (engineer, scientist, technician) to implement a PC-based acquisition system. Including both basic tutorial information as well as some advanced topics, this work is suitable as a reference book for engineers or as a supplemental text for engineering students. It gives the reader enough understanding of the topics to implement a data acquisition system based on commercial products. A reader can alternatively learn how to custom build hardware or write his or her own software.
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DEFF Research Database (Denmark)
Jensen, Morten Georg; Pedersen, C; Kristensen, Mette Bredal
2013-01-01
This review provides a critical update on human and animal studies investigating the effect of alginate supplementation on appetite regulation, glycaemic and insulinemic responses, and lipid metabolism with discussion of the evidence on potential mechanisms, efficacy and tolerability. Dependent...
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2011-04-19
...://regulations.gov , including any personal information provided. To confirm receipt of your comment, please... impacts, and equity). Executive Order 13563 emphasizes the importance of quantifying both costs and... terminated for default regardless of contract value. For Architect and Engineer (A&E) services, past...
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The science and regulations of probiotic food and supplement product labeling.
Sanders, Mary Ellen; Levy, Dan D
2011-02-01
Presented by the New York Academy of Sciences, the U.S. Food and Drug Administration (FDA), and the U.S. Office of Dietary Supplements of the National Institutes of Health, the symposium "Probiotic Foods and Supplements: The Science and Regulations of Labeling," was held on June 12, 2010 at the New York Academy of Sciences, New York, NY, the goals of which were to facilitate the exchange of ideas regarding labeling and substantiation of claims for probiotics among academic, industry, and regulatory professionals, and to discuss ways to translate and communicate research results in a truthful way to the consumer and to such health professionals as physicians, pharmacists, and dieticians. The target audience for this symposium included academicians interested in conducting research on the health benefits of probiotics; scientists; communications personnel, and regulatory specialists from companies involved in, or interested in, the marketing of probiotics; U.S. government regulatory experts tasked with oversight of probiotic foods and dietary supplement products; and other experts in the field interested in the development of probiotics for the U.S. market. © 2011 New York Academy of Sciences.
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48 CFR 18.113 - Interagency acquisitions under the Economy Act.
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Interagency acquisitions under the Economy Act. 18.113 Section 18.113 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available Acquisition Flexibilities 18.113 Interagency acquisitions under...
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2012-02-06
... Management; Agriculture Acquisition Regulation, Labor Law Violations; Withdrawal AGENCY: Office of... 422.70 entitled ``Labor Law Violations'' that would have a contractor certify upon accepting a contract that it is in compliance with all applicable labor laws and that, to the best of its knowledge...
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2010-03-18
... Services Administration Acquisition Regulation; Submission for OMB Review; Sales Practice Format--Supplies and/or Services With an Established Catalog Price and Sales Practices Format-- Supplies and/or... will be submitting to the Office of Management and Budget (OMB) a request to review and approve a new...
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2012-02-22
... Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor Excise Tax AGENCIES.... Additionally, the law stipulates that no funds are to be disbursed to any foreign contractor in order to... payment. Additionally, the law stipulates that no funds are to be disbursed to any foreign contractor in...
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48 CFR 32.003 - Simplified acquisition procedures financing.
2010-10-01
... procedures financing. 32.003 Section 32.003 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING 32.003 Simplified acquisition procedures financing. Unless agency regulations otherwise permit, contract financing shall not be provided for...
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2010-03-05
... ADMINISTRATION [OMB Control No. 9000-0032] Federal Acquisition Regulation; Submission for OMB Review; Contractor... previously approved information collection requirement concerning contractor use of interagency motor pool... contracting officer may authorize cost-reimbursement contractors to obtain, for official purposes only...
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48 CFR 1.102-3 - Acquisition team.
2010-10-01
... service. By identifying the team members in this manner, teamwork, unity of purpose, and open... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition team. 1.102-3... ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 1.102-3 Acquisition team. The purpose of defining...
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2012-07-26
... receive more frequent payments than every two weeks. The Contractor shall substantiate vouchers (including...] RIN 9000-AM01 Federal Acquisition Regulation; Payments Under Time-and-Materials and Labor-Hour... the authorization to use time-and-materials and labor-hour contract payment requirements. DATES...
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2010-05-24
... Acquisition Regulation; FAR Case 2009-027, Personal Identity Verification of Contractor Personnel AGENCIES... of collecting from contractors all forms of Government provided identification once they are no..., titled Controls Over the Contractor Common Access Card (CAC) Life Cycle, was performed to determine...
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Directory of Open Access Journals (Sweden)
Stanislav E. Kuzmin
2015-01-01
Full Text Available The article outlines general characteristics of the sources of law, regulating relations associated with mergers, consolidations, acquisitions of joint stock companies in Russia and corporations in the United States respectively in the Russian legislation and the legislation of the United States and individual States. Both in Russia and in the USA there is a constitutional separation of powers between the Federal authorities and the Subjects of the Federation/States respectively. In both countries legal regulation of mergers and acquisitions of corporations is carried out first of all by a number of laws. These laws fall into three main groups: securities laws, antitrust (competition laws and civil and joint-stock legislation in Russia and corporate laws in the US. All the three groups are federal laws in Russia, while in the US the first two are federal too, but the last one is state laws. It is necessary to highlight the important role of judicial decisions in the United States on legal regulation of mergers, acquisitions, takeovers in comparison with Russia, which is due to the differences in the legal systems of the states in question. However, although Russia is not a state of case law, such legal acts as the resolution of the Plenum of the Supreme Commercial Court will undoubtedly have an impact on law enforcement practice and, consequently, on the regulation of relevant relations. Of particular importance are the findings of the Constitutional Court, whose decisions may cancel acts or their separate provisions provided they are recognized as unconstitutional. Such acts are repealed. Decisions of courts and other bodies based on acts or their separate provisions, recognized by the Constitutional Court of the Russian Federation unconstitutional, are not subject to execution and shall be revised in accordance with the Federal law. The US case law implies existence of a hierarchy of precedents according to which decisions adopted by the
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2011-04-27
..., distributive impacts, and equity). Executive Order 13563 emphasizes the importance of quantifying both costs... Regulations System. Therefore, 48 CFR part 232 is amended as follows: PART 232--CONTRACT FINANCING 0 1. The...
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48 CFR 3032.003 - Simplified acquisition procedures financing.
2010-10-01
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Simplified acquisition procedures financing. 3032.003 Section 3032.003 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND... FINANCING Scope of Part 3032.003 Simplified acquisition procedures financing. Contract financing may be...
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2013-01-29
... 9000-AM13 Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor... contractor in order to reimburse the tax imposed (26 U.S.C. 5000C Note). On February 22, 2012, DoD, GSA, and... with the statute, FAR 31.205-41 is amended to inform the Government and contractors that the costs of...
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2012-08-10
... Acquisition Regulation; Small Business Set Asides for Research and Development Contracts AGENCY: Department of... when the market research conducted in accordance with FAR part 10 indicates there are small businesses... officer can proceed with a small business set-aside for research and development. FAR 19.502-2(b...
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48 CFR 34.004 - Acquisition strategy.
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition strategy. 34... CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION General 34.004 Acquisition strategy. The program manager, as specified in agency procedures, shall develop an acquisition strategy tailored to the particular...
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2012-06-29
... consistent with national laws, regulations, policies, and international obligations. The agreement does not... Kingdom of Great Britain and Northern Ireland * * * * * 252.225-7012 [Amended] 0 7. Amend section 252.225... Switzerland Turkey United Kingdom of Great Britain and Northern Ireland * * * * * 252.225-7021 [Amended] 0 9...
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48 CFR 234.004 - Acquisition strategy.
2010-10-01
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition strategy. 234..., DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION 234.004 Acquisition strategy. (1) See 209.570 for policy applicable to acquisition strategies that consider the use of lead system...
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2010-03-19
...-AL26 Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer..., Payments Under Fixed-Price Architect-Engineer Contracts, currently requires contracting officers to... judgment regarding the amount of payment withheld to apply under fixed-price architect-engineer (A-E...
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Organ acquisition cost centers Part I: medicare regulations--truth or consequence.
Abecassis, M
2006-12-01
Organ Acquisition Cost Centers (OACC) were designed to encourage and incentivize hospitals to provide transplantation services. The purpose of this article (Part I) is to familiarize transplant professionals and transplant center administrators with the regulations that govern OACC. An historical perspective of the evolution of these regulations is necessary to better understand the basic principles underlying this complex area of transplant finance. There is a wide variation in transplant center OACC reporting, suggesting under-reporting by some and overreporting by others. Correct reporting is essential since OACC are auditable. We have surveyed 13 audits by the Office of the Inspector General (OIG) of transplant center OACC in an attempt to identify trends in reporting practices by transplant centers that are not deemed acceptable by the OIG. We discuss these findings in the context of some basic definitions that refer specifically to cost accounting principles necessary for accurate reporting of OACC.
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48 CFR 307.104-70 - Acquisition strategy.
2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Acquisition strategy. 307... AND ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Planning 307.104-70 Acquisition strategy... designated by the HHS CIO, DASFMP, the CAO, or the cognizant HCA) shall prepare an acquisition strategy using...
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2010-01-28
.... Please cite OMB Control No. 9000-0114, Right of First Refusal of Employment, in all correspondence. Dated... ADMINISTRATION [OMB Control No. 9000-0114] Federal Acquisition Regulation; Submission for OMB Review; Right of... previously approved information collection requirement concerning right of first refusal of employment. A...
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Kim, Hye Kyung
2016-01-08
UV exposure is associated with oxidative stress and is the primary factor in skin photoaging. UV-induced reactive oxygen species (ROS) cause the up-regulation of metalloproteinase (MMPs) and the degradation of dermal collagen and elastic fibers. Garlic and its components have been reported to exert antioxidative effects. The present study investigated the protective effect of garlic on UV-induced photoaging and MMPs regulation in hairless mice. Garlic was supplemented in the diet, and Skh-1 hairless mice were exposed to UV irradiation five days/week for eight weeks. Mice were divided into four groups; Non-UV, UV-irradiated control, UV+1% garlic powder diet group, and UV+2% garlic powder diet group. Chronic UV irradiation induced rough wrinkling of the skin with hyperkeratosis, and administration of garlic diminished the coarse wrinkle formation. UV-induced dorsal skin and epidermal thickness were also ameliorated by garlic supplementation. ROS generation, skin and serum malondialdehyde levels were significantly increased by UV exposure and were ameliorated by garlic administration although the effects were not dose-dependent. Antioxidant enzymes such as superoxide dismutase and catalase activities in skin tissues were markedly reduced by UV irradiation and garlic treatment increased these enzyme activities. UV-induced MMP-1 and MMP-2 protein levels were suppressed by garlic administration. Furthermore, garlic supplementation prevented the UV-induced increase of MMP-1 mRNA expression and the UV-induced decrease of procollagen mRNA expression. These results suggest that garlic may be effective for preventing skin photoaging accelerated by UV irradiation through the antioxidative system and MMP regulation.
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How to Assist Formalization of NL Regulations: Lessons from Business Rules Acquisition Experiments
Nazarenko , Adeline
2013-01-01
International audience; Decision systems usually rely on a set of business rules that describe the expected behavior of a system or an organization and that determine the decisions to be taken in different situations. However, rule acquisition is often the bottleneck that hinders the development of decision systems. When these rules are based on regulations written in Natural Language (NL), one solution is to derive formal business rules from the source documents. This approach also allows ch...
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Kim, Woori; Linan-Thompson, Sylvia
2013-01-01
This multiple-probe study examined the effects of self-regulation on the acquisition of science vocabulary by four third-grade English language learners (ELLs) with learning difficulties. The students were provided only direct vocabulary instruction in a baseline phase, followed by intervention and maintenance phases into which self-regulation…
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78 FR 18349 - Federal Acquisition Regulation; Information Collection; Commercial Item Acquisitions
2013-03-26
... information provided. FOR FURTHER INFORMATION CONTACT: Mr. Michael O. Jackson, Procurement Analyst, Office of Governmentwide Acquisition Policy, GSA (202) 208- 4949 or email at michaelo.jackson@gsa.gov . SUPPLEMENTARY...
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Fatima, Sadia; Gerasimidis, Konstantinos; Wright, Charlotte; Tsiountsioura, Melina; Arvanitidou, Eirini-Iro; Malkova, Dalia
2015-12-01
The net clinical benefit of high-energy nutritional supplements (HENSDs) consumption is lower than expected. To investigate the extent to which consumption of oral HENSD in the fasted state reduces energy intake in slim females during consecutive breakfast and lunch, and whether this relates to changes in appetite and metabolic appetite regulators. Twenty three females of 24.4 ± 2.8 years with BMI of 18.2 ± 0.8 kg/m(2) consumed HENSD (2.5 MJ) or PLACEBO (0.4 MJ) in fasted state in a single blind randomized cross-over study. Appetite and metabolic rate measurements and blood collection were conducted prior to and during 240 min after the intake of the supplements. Energy intake was recorded during ad libitum buffet breakfast and lunch served 60 min and 240 min post supplementation respectively. Energy intake during breakfast was significantly (P appetite measures were not significantly different between HENSD and PLACEBO trials. Correlations for the within participant relations between the responses of plasma hormones and appetite scores were significant (P < 0.05) for PYY and insulin but not CCK. The energy expended above resting metabolic rate was significantly (P < 0.05) higher in the HENDS trial but relative increase in energy expenditure was not significantly different between the two trials. Oral high-energy nutritional supplements have a partial and relatively short lived suppressive action on energy intake and can be expected to increase net energy intake by approximately half the energy value of the supplement consumed. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.
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Deconinck, E; Djiogo, C A Sokeng; Bothy, J L; Courselle, P
2017-08-05
The identification of a specific toxic or regulated plant in herbal preparations or plant food supplements is a real challenge, since they are often powdered, mixed with other herbal or synthetic powders and compressed into tablets or capsules. The classical identification approaches based on micro- and macroscopy are therefore not possible anymore. In this paper infrared spectroscopy, combined with attenuated total reflectance was evaluated for the screening of plant based preparations for nine specific plants (five regulated and four common plants for herbal supplements). IR and NIR spectra were recorded for a series of self-made triturations of the targeted plants. After pretreatment of the spectral data chemometric classification techniques were applied to both data sets (IR and NIR) separately and the combination of both. The results show that the screening of herbal preparations or plant food supplements for specific plants, using infrared spectroscopy, is feasible. The best model was obtained with the Mid-IR data, using SIMCA as modelling technique. During validation of the model, using an external test set, 21 of 25 were correctly classified and six of the nine targeted plants showed no misclassifications for the selected test set. For the other three a success rate of 50% was obtained. Mid-IR combined with SIMCA can therefore be applied as a first step in the screening of unknown samples, before applying more sophisticated fingerprint approaches or identification tests described in several national and international pharmacopoeia. As a proof of concept five real suspicious samples were successfully screened for the targeted regulated plants. Copyright © 2017 Elsevier B.V. All rights reserved.
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78 FR 46795 - Federal Acquisition Regulation; Technical Amendments
2013-08-01
... changes to the FAR. List of Subject in 48 CFR Parts 2, 22, and 52 Government procurement. Dated: July 26, 2013. William Clark, Acting Director, Office of Government-wide Acquisition Policy, Office of Acquisition Policy, Office of Government-wide Policy. Therefore, DoD, GSA, and NASA amend 48 CFR parts 2, 22...
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30 CFR 256.12 - Supplemental sales.
2010-07-01
... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Supplemental sales. 256.12 Section 256.12..., General § 256.12 Supplemental sales. (a) The Secretary may conduct a supplemental sale in accordance with the provisions of this section. (b) Supplemental sales shall be governed by the regulations in this...
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48 CFR 307.7001 - Distinction between acquisition and assistance.
2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Distinction between acquisition and assistance. 307.7001 Section 307.7001 Federal Acquisition Regulations System HEALTH AND HUMAN... barter, of property or services for the direct benefit or use of the Government; or (2) Government...
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2011-08-19
... responsibility for compliance with export control law and regulations a ``due diligence responsibility.'' DoD... clearance officer suspects data integrity issues; however, 245.602-1(2) has been clarified to specify... that the supplier name and part number be required for all items in Federal condition code A1 being...
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2010-03-19
... 9000-AL23 Federal Acquisition Regulation; FAR Case 2008-036, Trade Agreements--Costa Rica, Oman, and... United States-Oman Free Trade Agreement, and the United States-Peru Trade Promotion Agreement. DATES... interim rule. The interim rule added Costa Rica, Oman, and Peru to the definition of ``Free Trade...
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10 CFR 626.4 - General acquisition strategy.
2010-01-01
... 10 Energy 4 2010-01-01 2010-01-01 false General acquisition strategy. 626.4 Section 626.4 Energy DEPARTMENT OF ENERGY (CONTINUED) SALES REGULATION PROCEDURES FOR ACQUISITION OF PETROLEUM FOR THE STRATEGIC PETROLEUM RESERVE § 626.4 General acquisition strategy. (a) Criteria for commencing acquisition. To reduce...
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48 CFR 18.106 - Acquisitions from Federal Prison Industries, Inc. (FPI).
2010-10-01
... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisitions from Federal Prison Industries, Inc. (FPI). 18.106 Section 18.106 Federal Acquisition Regulations System FEDERAL... Flexibilities 18.106 Acquisitions from Federal Prison Industries, Inc. (FPI). Purchase from FPI is not mandatory...
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Deconinck, E; Sokeng Djiogo, C A; Courselle, P
2017-09-05
Plant food supplements are gaining popularity, resulting in a broader spectrum of available products and an increased consumption. Next to the problem of adulteration of these products with synthetic drugs the presence of regulated or toxic plants is an important issue, especially when the products are purchased from irregular sources. This paper focusses on this problem by using specific chromatographic fingerprints for five targeted plants and chemometric classification techniques in order to extract the important information from the fingerprints and determine the presence of the targeted plants in plant food supplements in an objective way. Two approaches were followed: (1) a multiclass model, (2) 2-class model for each of the targeted plants separately. For both approaches good classification models were obtained, especially when using SIMCA and PLS-DA. For each model, misclassification rates for the external test set of maximum one sample could be obtained. The models were applied to five real samples resulting in the identification of the correct plants, confirmed by mass spectrometry. Therefore chromatographic fingerprinting combined with chemometric modelling can be considered interesting to make a more objective decision on whether a regulated plant is present in a plant food supplement or not, especially when no mass spectrometry equipment is available. The results suggest also that the use of a battery of 2-class models to screen for several plants is the approach to be preferred. Copyright © 2017 Elsevier B.V. All rights reserved.
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Schiff, Hillary C; Johansen, Joshua P; Hou, Mian; Bush, David E A; Smith, Emily K; Klein, JoAnna E; LeDoux, Joseph E; Sears, Robert M
2017-03-01
Memory formation requires the temporal coordination of molecular events and cellular processes following a learned event. During Pavlovian threat (fear) conditioning (PTC), sensory and neuromodulatory inputs converge on post-synaptic neurons within the lateral nucleus of the amygdala (LA). By activating an intracellular cascade of signaling molecules, these G-protein-coupled neuromodulatory receptors are capable of recruiting a diverse profile of plasticity-related proteins. Here we report that norepinephrine, through its actions on β-adrenergic receptors (βARs), modulates aversive memory formation following PTC through two molecularly and temporally distinct signaling mechanisms. Specifically, using behavioral pharmacology and biochemistry in adult rats, we determined that βAR activity during, but not after PTC training initiates the activation of two plasticity-related targets: AMPA receptors (AMPARs) for memory acquisition and short-term memory and extracellular regulated kinase (ERK) for consolidating the learned association into a long-term memory. These findings reveal that βAR activity during, but not following PTC sets in motion cascading molecular events for the acquisition (AMPARs) and subsequent consolidation (ERK) of learned associations.
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77 FR 59339 - Acquisition of Commercial Items
2012-09-27
... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 212 Acquisition of Commercial Items CFR Correction 212.504 [Corrected] In Title 48 of the Code of Federal Regulations, Chapter 2 (Parts 201--299), revised as of October 1, 2011, on page 73, in section 212.504, paragraph (a) is...
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48 CFR 2953.102 - Quotation for Simplified Acquisitions DL 1-2078.
2010-10-01
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Quotation for Simplified Acquisitions DL 1-2078. 2953.102 Section 2953.102 Federal Acquisition Regulations System DEPARTMENT OF LABOR CLAUSE AND FORMS FORMS General 2953.102 Quotation for Simplified Acquisitions DL 1-2078. The following...
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Prose Learning for Veterinary Educators: Facilitating Acquisition
Harkness, John E.
1978-01-01
A prose text in veterinary medicine can be arranged and supplemented to facilitate efficient and effective acquisition into short-term memory. Methods include: variation in textual format; relating new information to previous knowledge and future goals; providing specific, test-relevant objectives or introductions, describing mnemonic devices; and…
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Regulations for the safe transport of radioactive material. 1985 ed. Supplement 1986
International Nuclear Information System (INIS)
1986-01-01
Following a six-year effort, a major revision to the Agency's Regulations for the Safe Transport of Radioactive Material (Safety Series No. 6) was issued in 1985. In order to address minor problems with the 1985 Edition of Safety Series No. 6, a panel of experts convened by the International Atomic Energy Agency met from 13 to 17 January 1986. This panel considered minor inconsistencies, omissions or errors that had occurred in the course of preparing the 1985 Edition of Safety Series No. 6, and recommended that two types of change be made. First, changes which will correct errors in the presentation of the text, translation errors (in the French, Russian and Spanish versions of the 1985 Edition), and drafting which failed to express the intent of the panels which reviewed the previous edition of the Regulations; these minor changes are promulgated herewith by the authority of the Director General. Secondly, changes of detail which can only be introduced in accordance with the procedure approved by the Board of Governors on 22 September 1972, which authorizes the Director General to promulgate such changes after giving Governments not less than ninety days' notice and taking into account any comments that they make. Three changes of this second type were recommended by the panel, and were circulated according to the 'ninety-day rule' amendment procedure on 3 February 1986. Those changes which received unanimous support by Member States are included in this Supplement. Corrected text to the 1985 Edition of Safety Series No. 6 (paragraphs, tables, etc.) is provided in this Supplement, and this corrected text supersedes the corresponding portions of the 1985 Edition of Safety Series No. 6.
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43 CFR 7.32 - Supplemental definitions.
2010-10-01
... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Supplemental definitions. 7.32 Section 7... RESOURCES Department of the Interior Supplemental Regulations § 7.32 Supplemental definitions. For purposes of this subpart, the following definitions will be used: (a) Site of religious or cultural importance...
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48 CFR 1401.370 - Acquisition Managers' Partnership.
2010-10-01
...' Partnership. 1401.370 Section 1401.370 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR... Acquisition Managers' Partnership. (a) The Acquisition Managers' Partnership (AMP) is a forum for DOI's senior... the partnership will meet and develops meeting agendas. The Chairperson will distribute the meeting...
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Si, Meiru; Wang, Yao; Zhang, Bing; Zhao, Chao; Kang, Yiwen; Bai, Haonan; Wei, Dawei; Zhu, Lingfang; Zhang, Lei; Dong, Tao G; Shen, Xihui
2017-07-25
The type VI secretion system was recently reported to be involved in zinc acquisition, but the underlying mechanism remains unclear. Here, we report that Burkholderia thailandensis T6SS4 is involved in zinc acquisition via secretion of a zinc-scavenging protein, TseZ, that interacts with the outer membrane heme transporter HmuR. We find that HmuR is a redox-regulated dual-functional transporter that transports heme iron under normal conditions but zinc upon sensing extracellular oxidative stress, triggered by formation of an intramolecular disulfide bond. Acting as the first line of defense against oxidative stress, HmuR not only guarantees an immediate response to the changing environment but also provides a fine-tuned mechanism that allows a gradual response to perceived stress. The T6SS/HmuR-mediated active zinc transport system is also involved in bacterial virulence and contact-independent bacterial competition. We describe a sophisticated bacterial zinc acquisition mechanism affording insights into the role of metal ion transport systems. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
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48 CFR 1825.1101 - Acquisition of supplies.
2010-10-01
....225-8, Duty-Free Entry of Space Articles, in solicitations and contracts when the supplies that will... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Acquisition of supplies... ADMINISTRATION SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Solicitation Provisions and Contract Clauses 1825.1101...
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Dietary supplement good manufacturing practices: preparing for compliance
National Research Council Canada - National Science Library
Mead, William J
2012-01-01
"Dietary Supplement GMP is a one-stop "how-to" road map to the final dietary supplement GMP regulations recently issued by the FDA covering the manufacture, packaging, and holding of dietary supplement...
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48 CFR 1371.102 - Method of payment and invoicing instructions for ship repair.
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Method of payment and invoicing instructions for ship repair. 1371.102 Section 1371.102 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE DEPARTMENT SUPPLEMENTAL REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP REPAIR Provisions and Clauses 1371.102...
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48 CFR 1371.118 - Changes-ship repair.
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Changes-ship repair. 1371.118 Section 1371.118 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE DEPARTMENT SUPPLEMENTAL REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP REPAIR Provisions and Clauses 1371.118 Changes—ship repair. Insert clause...
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48 CFR 1552.232-74 - Payments-simplified acquisition procedures financing.
2010-10-01
... acquisition procedures financing. 1552.232-74 Section 1552.232-74 Federal Acquisition Regulations System... Provisions and Clauses 1552.232-74 Payments—simplified acquisition procedures financing. As prescribed in... acquisition procedures financing. Payments—Simplified Acquisition Procedures Financing (JUN 2006) Simplified...
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2013-08-30
... provided. FOR FURTHER INFORMATION CONTACT: Mr. Michael O. Jackson, Procurement Analyst, Office of Governmentwide Acquisition Policy, GSA (202) 208- 4949 or email at michaelo.jackson@gsa.gov . SUPPLEMENTARY...
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Leucine supplementation protects from insulin resistance by regulating adiposity levels.
Directory of Open Access Journals (Sweden)
Elke Binder
Full Text Available BACKGROUND: Leucine supplementation might have therapeutic potential in preventing diet-induced obesity and improving insulin sensitivity. However, the underlying mechanisms are at present unclear. Additionally, it is unclear whether leucine supplementation might be equally efficacious once obesity has developed. METHODOLOGY/PRINCIPAL FINDINGS: Male C57BL/6J mice were fed chow or a high-fat diet (HFD, supplemented or not with leucine for 17 weeks. Another group of HFD-fed mice (HFD-pairfat group was food restricted in order to reach an adiposity level comparable to that of HFD-Leu mice. Finally, a third group of mice was exposed to HFD for 12 weeks before being chronically supplemented with leucine. Leucine supplementation in HFD-fed mice decreased body weight and fat mass by increasing energy expenditure, fatty acid oxidation and locomotor activity in vivo. The decreased adiposity in HFD-Leu mice was associated with increased expression of uncoupling protein 3 (UCP-3 in the brown adipose tissue, better insulin sensitivity, increased intestinal gluconeogenesis and preservation of islets of Langerhans histomorphology and function. HFD-pairfat mice had a comparable improvement in insulin sensitivity, without changes in islets physiology or intestinal gluconeogenesis. Remarkably, both HFD-Leu and HFD-pairfat mice had decreased hepatic lipid content, which likely helped improve insulin sensitivity. In contrast, when leucine was supplemented to already obese animals, no changes in body weight, body composition or glucose metabolism were observed. CONCLUSIONS/SIGNIFICANCE: These findings suggest that leucine improves insulin sensitivity in HFD-fed mice by primarily decreasing adiposity, rather than directly acting on peripheral target organs. However, beneficial effects of leucine on intestinal gluconeogenesis and islets of Langerhans's physiology might help prevent type 2 diabetes development. Differently, metabolic benefit of leucine supplementation
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2010-04-08
... regulations and prescribes a contract clause to address those responsibilities. DATES: Effective Date: April 8... activities and communication between the parties to a potential contract, and to have the resulting contract... Government needs to convey to the universities the information that certain work is export-controlled. DoD...
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Directory of Open Access Journals (Sweden)
Rosario Barone
Full Text Available A new role for fat supplements, in particular conjugated linoleic acid (CLA, has been delineated in steroidogenesis, although the underlying molecular mechanisms have not yet been elucidated. The aims of the present study were to identify the pathway stimulated by CLA supplementation using a cell culture model and to determine whether this same pathway is also stimulated in vivo by CLA supplementation associated with exercise. In vitro, Leydig tumour rat cells (R2C supplemented with different concentrations of CLA exhibited increasing testosterone biosynthesis accompanied by increasing levels of CYP17A1 mRNA and protein. In vivo, trained mice showed an increase in free plasma testosterone and an up-regulation of CYP17A1 mRNA and protein. The effect of training on CYP17A1 expression and testosterone biosynthesis was significantly higher in the trained mice supplemented with CLA compared to the placebo. The results of the present study demonstrated that CLA stimulates testosterone biosynthesis via CYP17A1, and endurance training led to the synthesis of testosterone in vivo by inducing the overexpression of CYP17A1 mRNA and protein in the Leydig cells of the testis. This effect was enhanced by CLA supplementation. Therefore, CLA-associated physical activity may be used for its steroidogenic property in different fields, such as alimentary industry, human reproductive medicine, sport science, and anti-muscle wasting.
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78 FR 46779 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-69; Introduction
2013-08-01
... recommendations from the Government Accountability Office Report GAO-09-374, Better Performance Information Needed... requirements on small business. Item IV--Repeal of Sunset for Certain Protests of Task and Delivery Order... treated as designated countries. In acquisitions that are covered by the World Trade Organization...
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77 FR 13951 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-57; Introduction
2012-03-07
... Trade Organization Government Procurement Agreement (WTO GPA). This Free Trade Agreement now covers acquisition of supplies and services between $100,000 and the current WTO GPA threshold of $202,000. This... effective March 15, 2012. Dated: March 1, 2012. Richard Ginman, Director, Defense Procurement and...
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Yakar, Shoshana; Isaksson, Olle
2016-06-01
The growth hormone (GH) and its downstream mediator, the insulin-like growth factor-1 (IGF-1), construct a pleotropic axis affecting growth, metabolism, and organ function. Serum levels of GH/IGF-1 rise during pubertal growth and associate with peak bone acquisition, while during aging their levels decline and associate with bone loss. The GH/IGF-1 axis was extensively studied in numerous biological systems including rodent models and cell cultures. Both hormones act in an endocrine and autocrine/paracrine fashion and understanding their distinct and overlapping contributions to skeletal acquisition is still a matter of debate. GH and IGF-1 exert their effects on osteogenic cells via binding to their cognate receptor, leading to activation of an array of genes that mediate cellular differentiation and function. Both hormones interact with other skeletal regulators, such as sex-steroids, thyroid hormone, and parathyroid hormone, to facilitate skeletal growth and metabolism. In this review we summarized several rodent models of the GH/IGF-1 axis and described key experiments that shed new light on the regulation of skeletal growth by the GH/IGF-1 axis. Copyright © 2015 Elsevier Ltd. All rights reserved.
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75 FR 51416 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items
2010-08-20
... provided clarification regarding situations under which the procurement of a major weapon system..., et seq. List of Subjects in 48 CFR Parts 202, 212, and 234 Government procurement. Ynette R. Shelkin...: DoD is adopting as final, without change, the interim rule that amended the Defense Federal...
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77 FR 56737 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-61; Introduction
2012-09-13
... Trade Organization Government Procurement Agreement (WTO GPA). The Korea Free Trade Agreement now covers acquisition of supplies and services between $100,000 and the current WTO GPA threshold of $202,000. This...'', which is no longer in existence. There is no impact to the Government or small business because this...
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Training and Doctrine Command Acquisition Management and Oversight Supplement
2011-06-01
the foundation for all future procurement decisions. Chapter 4 of TR 5-14 requires the RA to gain approval and certification by the designated...CLM013-Work-Breakdown Structure CLM031-Improved Statement of Work ACQ265-Mission Focused Services Acquisition Army eLearning https...will be returned to acceptable levels, and how recurrence of the cause will be prevented in the future . 53 7.3. Performance Requirements Summary
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48 CFR 53.212 - Acquisition of commercial items.
2010-10-01
... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Acquisition of commercial... (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.212 Acquisition of commercial items. SF 1449 (Rev. 3/2005), Solicitation/Contract/Order for Commercial Items. SF 1449 is prescribed for use in...
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THE EFFECT OF n-3 LC-PUFA SUPPLEMENTATION ON TENNIS SKILL ACQUISITION IN 10-12 YEAR OLD GIRLS
Directory of Open Access Journals (Sweden)
Asuman Şahan
2012-07-01
Full Text Available The purpose of this study was to investigate the effects of 16 weeks of n-3 LC-PUFA (omega 3 long-chain polyunsaturated fatty acid supplementation on tennis skill acquisition in 10-12 year old girls. This research was a single-blind placebo-controlled trial. 29 girls (10-12 years of age who had never played tennis before took part in the study. Ball Throws to the Target (BTT and Tennis Ability Test (TAT were performed three times. Before participants were allocated to the groups and received n-3 LC-PUFA or olive oil, they underwent preparatory training for three weeks. Anthropometric measurements, nutrition analysis, and 1st BTT and TAT tests were performed and they continued the preparatory training until the 3rd week. Then they were randomly allocated to two groups to receive either n-3 LC-PUFA (omega group; 670 mg · day-1; n=16 or olive oil (placebo group; 670 mg · day-1; n=13 during 16 weeks of tennis training which involved 3 hours per week for 19 weeks. The results show that significant improvements in TAT were found in both groups but the omega group had significantly higher scores than the placebo group at the 3rd measurements. Although there were no differences between groups at all measurements of BTT, the omega group showed significant improvement between the 1st and 3rd measurements. This study suggests that daily 670 mg n-3 LC-PUFA supplementation for 16 weeks might improve tennis ability test scores of 10-12 year old girls.
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48 CFR 206.303-70 - Acquisitions in support of operations in Iraq or Afghanistan.
2010-10-01
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisitions in support of operations in Iraq or Afghanistan. 206.303-70 Section 206.303-70 Federal Acquisition Regulations System... Afghanistan. The justification and approval addressed in FAR 6.303 is not required for acquisitions conducted...
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48 CFR 939.7002 - Contractor acquisition of information technology.
2010-10-01
... information technology. 939.7002 Section 939.7002 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Implementing DOE Policies and Procedures 939.7002 Contractor acquisition of information technology. (a) Management and operating (M&O...
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48 CFR 9904.411 - Cost accounting standard-accounting for acquisition costs of material.
2010-10-01
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Cost accounting standard-accounting for acquisition costs of material. 9904.411 Section 9904.411 Federal Acquisition Regulations System COST ACCOUNTING STANDARDS BOARD, OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND...
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Ringseis, Robert; Keller, Janine; Eder, Klaus
2018-02-01
Carnitine has long been known to play a critical role for energy metabolism. Due to this, a large number of studies have been carried out to investigate the potential of supplemental carnitine in improving performance of livestock animals including ruminants, with however largely inconsistent results. An important issue that has to be considered when using carnitine as a feed additive is that the efficacy of supplemental carnitine is probably dependent on the animal's carnitine status, which is affected by endogenous carnitine synthesis, carnitine uptake from the gastrointestinal tract and carnitine excretion. The present review aims to summarise the current knowledge of the regulation of carnitine status and carnitine homeostasis in ruminants, and comprehensively evaluate the efficacy of carnitine supplementation on performance and/or health in ruminant livestock by comparing the outcomes of studies with carnitine supplementation in dairy cattle, growing and finishing cattle and sheep. While most of the studies show that supplemental carnitine, even in ruminally unprotected form, is bioavailable in ruminants, its effect on either milk or growth performance is largely disappointing. However, supplemental carnitine appears to be a useful strategy to offer protection against ammonia toxicity caused by consumption of high levels of non-protein N or forages with high levels of soluble N both, in cattle and sheep.
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48 CFR 227.7103-2 - Acquisition of technical data.
2010-10-01
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition of technical... Rights in Technical Data 227.7103-2 Acquisition of technical data. (a) Contracting officers shall work... personnel are responsible for identifying the Government's minimum needs for technical data. Data needs must...
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7 CFR 1735.62 - Approval of acquisitions and mergers.
2010-01-01
... 7 Agriculture 11 2010-01-01 2010-01-01 false Approval of acquisitions and mergers. 1735.62 Section 1735.62 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE... Mortgage Controls on Acquisitions and Mergers § 1735.62 Approval of acquisitions and mergers. (a) If a...
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7 CFR 982.16 - Inshell trade acquisitions.
2010-01-01
... acquisitions means the quantity of inshell hazelnuts acquired by the trade from all handlers during a marketing... 7 Agriculture 8 2010-01-01 2010-01-01 false Inshell trade acquisitions. 982.16 Section 982.16 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...
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Herbal Supplements: What to Know Before You Buy
... Nutrition and healthy eating Regulations ensure that herbal supplements meet manufacturing standards but don't guarantee that ... of herbal remedies goes on and on. Herbal supplements, sometimes called botanicals, are one type of dietary ...
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48 CFR 1532.003 - Simplified acquisition procedures financing.
2010-10-01
... procedures financing. 1532.003 Section 1532.003 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING 1532.003 Simplified acquisition procedures financing. (a) Scope. This subpart provides for authorization of advance and interim payments on...
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[Marketability of food supplements - criteria for the legal assessment].
Breitweg-Lehmann, Evelyn
2017-03-01
To be placed on the market legally, food supplements have to meet national and European food law regulations. This is true for all substances used as well as for the labeling on the packaging of and the advertising for food supplements. The food business operator is responsible for its compliance with all regulations. Therefore, in this article, a concise step-by-step assessment is presented, covering all necessary legal requirements to market food supplements. Additionally, all steps are visualized in a flow chart. All vitamins, minerals and other substances used have to meet the legal conditions. Food business operators have to make sure that their products do not contain medicinal ingredients based on their pharmacologic effect. It is prohibited to place medicinal products as food supplements on the market. Furthermore, food business operators have to make sure that their products are not non-authorized novel foods according to the novel food regulation (EC) no. 258/97. Also, food supplements have to meet the requirements of article 14 of Regulation (EC) No. 178/2002 concerning the safety of foodstuff. Food shall not be placed on the market if it is unsafe. For food supplements that fail the German food-related legal standards but are legally manufactured in another EU member state or are legally put into circulation, the importer requires the so-called general disposition, which must be applied for at the BVL according to § 54 of the German Food and Feed Act. Another possibility for food which fails to meet German food law is to apply for a certificate of exemption according to § 68 of the Food and Feed Act. The food business operator has to meet the harmonized regulations concerning maximum and minimum levels of additives, flavors and enzymes. The packaging has to meet the compulsory labeling as well the voluntary labeling, like health claims. The BVL is also the relevant authority for other tasks concerning food supplements. A figure shows all
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Directory of Open Access Journals (Sweden)
Yinghui Li
2016-03-01
Full Text Available This experiment was conducted to investigate the effects of branched-chain amino acids (BCAA supplemented in protein-restricted diets on the growth performance and the expression profile of amino acid transporters and energy metabolism related regulators in the white adipose tissue (WAT of different regional depots including dorsal subcutaneous adipose (DSA and abdominal subcutaneous adipose (ASA. A total of 24 crossbred barrows (7.40 ± 0.70 kg were randomly divided into 4 groups and were fed the following isocaloric diets for 33 days: 1 a recommended adequate protein diet (AP, 20% CP, as a positive control; 2 a low protein diet (LP, 17% CP; 3 the LP diet supplemented with BCAA (LP + B, 17% CP to reach the same level of the AP diet group; 4 the LP diet supplemented with 2 times the amount of BCAA (LP + 2B, 17% CP. The daily gain and daily feed intake of the LP diet group were the lowest among all the treatments (P 0.05. Moreover, BCAA supplementation down-regulated the expression levels of amino acid transporters including L-type amino acid transporter 1 and sodium-coupled neutral amino acid transporter 2 in DSA, but up-regulated the expression level of L-type amino acid transporter 4 in ASA (P < 0.05. Meanwhile, the energy sensor AMP-activated protein kinase α was activated in the DSA of pigs fed LP diet and in the ASA of the pigs fed AP or LP + 2B diets (P < 0.05. The mRNA expression profile of the selected mitochondrial component and mitochondrial biogenesis associated regulators in DSA and ASA also responded differently to dietary BCAA supplementation. These results suggested that the growth performance of growing pigs fed protein restricted diets supplemented with BCAA could catch up to that of the pigs fed AP diets. The results also partly demonstrated that the regulation mechanisms of BCAA are different in the adipose tissues of different depots.
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48 CFR 1845.505-14 - Reports of Government property. (NASA supplements paragraphs (b))
2010-10-01
.... (NASA supplements paragraphs (b)) (b) When the clause at 1852.245-73, Financial Reporting of NASA... contractor acquired property for purposes of reporting the acquisition cost in the property classifications...
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48 CFR 432.003 - Simplified acquisition procedures financing.
2010-10-01
... procedures financing. 432.003 Section 432.003 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING 432.003 Simplified acquisition procedures financing. (a) The chief of the contracting office may approve contract financing on a contract to be...
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48 CFR 1332.003 - Simplified acquisition procedures financing.
2010-10-01
... procedures financing. 1332.003 Section 1332.003 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING 1332.003 Simplified acquisition procedures financing. Contract financing may be provided for purchases made under the authority of FAR Part 13. Contract...
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Regulating the South African sport supplement industry: 'Whey ...
African Journals Online (AJOL)
immune improvement claims, the exact benefits of sport supplements have not been ... Among those that ranked highest were Dis-Chem's house brand,. Biogen ... the establishment of the SA Health Products Regulatory Authority. (SAHPRA) ...
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48 CFR 245.7311-2 - Safety, security, and fire regulations.
2010-10-01
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Safety, security, and fire regulations. 245.7311-2 Section 245.7311-2 Federal Acquisition Regulations System DEFENSE ACQUISITION... Inventory 245.7311-2 Safety, security, and fire regulations. ...
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12 CFR 204.7 - Supplemental reserve requirement.
2010-01-01
... 12 Banks and Banking 2 2010-01-01 2010-01-01 false Supplemental reserve requirement. 204.7 Section... RESERVE REQUIREMENTS OF DEPOSITORY INSTITUTIONS (REGULATION D) § 204.7 Supplemental reserve requirement... reserve requirement on every depository institution of not more than 4 percent of its total transaction...
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76 FR 12795 - Department of Education Acquisition Regulation
2011-03-08
... 3402 Definitions of words and terms 3403 Improper business practices and personal conflicts of interest... commercial items SUBCHAPTER C--CONTRACTING METHODS AND CONTRACT TYPES 3413 Simplified acquisition procedures 3414 Sealed bidding 3415 Contracting by negotiation 3416 Types of contracts 3417 Special contracting...
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2010-01-12
..., ammunition, or war materials) from the SC/CASA states to support operations in Afghanistan. The end of the... in Support of Operations in Afghanistan AGENCY: Department of Defense (DoD). ACTION: Proposed rule...
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2010-01-06
..., ammunition, or war materials) from the SC/CASA states to support operations in Afghanistan. DATES: Comment... in Afghanistan (DFARS Case 2009-D012) AGENCY: Department of Defense (DoD). ACTION: Proposed rule with... Afghanistan. This waiver applies to offers of products and services from the following nine South Caucasus...
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2010-02-24
... limited to, cost-effective measures intended to achieve the following: (i) Competitive prototyping. (ii... subsystems. (v) Use of modular, open architectures to enable competition for upgrades. (vi) Use of build-to...
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48 CFR 1371.107 - Performance.
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Performance. 1371.107 Section 1371.107 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE DEPARTMENT SUPPLEMENTAL... Performance. Insert clause 1352.271-76, Performance, in all solicitations and contracts for ship construction...
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48 CFR 252.225-7025 - Restriction on acquisition of forgings.
2010-10-01
... of forgings. 252.225-7025 Section 252.225-7025 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.225-7025 Restriction on acquisition of forgings. As prescribed in 225.7102-4, use the following clause: Restriction on Acquisition of Forgings (DEC 2009) (a...
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Issues in Nutrition: Dietary Supplements.
Thompson, Margaret E; Noel, Mary Barth
2017-01-01
The majority of American adults report use of one or more dietary supplements every day or occasionally. The Dietary Supplement Health and Education Act of 1994 defines dietary supplements and regulates their manufacture and distribution. One of the most commonly used supplements is vitamin D. Measurement of serum levels of vitamin D must be undertaken with the caveats that different laboratories define normal levels differently, and that there is rarely a clinical correlation with the actual level. Patients should understand that supplements should not be used to excess, as there are toxicities and other adverse effects associated with most of them. There currently is considerable research being performed on probiotics and how the gut microbiome affects health and disease states. Protein supplements may be useful in reducing mortality rates in elderly patients but they do not appear to increase quality of life. If used, protein supplements should contain essential amino acids. Casein and whey supplements, derived from dairy sources, help transport essential amino acids to tissues. Although there have been many studies investigating the role of vitamin supplements in disease prevention, there have been few conclusive positive results. Written permission from the American Academy of Family Physicians is required for reproduction of this material in whole or in part in any form or medium.
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2012-03-07
... Trade Organization Government Procurement Agreement (WTO GPA). This Free Trade Agreement now covers acquisition of supplies and services between $100,000 and the current WTO GPA threshold of $202,000. This...
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Muscle Mass and Weight Gain Nutritional Supplements
Campbell, Bill
There are numerous sports supplements available that claim to increase lean body mass. However, for these sports supplements to exert any favorable changes in lean body mass, they must influence those factors regulating skeletal muscle hypertrophy (i.e., satellite cell activity, gene transcription, protein translation). If a given sports supplement does favorably influence one of these regulatory factors, the result is a positive net protein balance (in which protein synthesis exceeds protein breakdown). Sports supplement categories aimed at eliciting a positive net protein balance include anabolic hormone enhancers, nutrient timing pre- and postexercise workout supplements, anticatabolic supplements, and nitric oxide boosters. Of all the sports supplements available, only a few have been subject to multiple clinical trials with repeated favorable outcomes relative to increasing lean body mass. This chapter focuses on these supplements and others that have a sound theoretical rationale in relation to increasing lean body mass.
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2012-04-03
... to which technology, economic conditions, or other factors have changed in the area affected by the... comments on factors described in the Supplementary Information. DATES: Comments must be received by VA on... (003A2A), Office of Acquisition, Logistics and Construction, Department of Veterans Affairs, 810 Vermont...
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HERBAL SUPPLEMENTS: CAUSE FOR CONCERN?
Paolo Borrione; Luigi Di Luigi; Nicola Maffulli; Fabio Pigozzi
2008-01-01
More than 1400 herbal products or herbal-derived compounds are commonly commercialised for health uses worldwide (Tyler, 1996). Herbs are considered dietary supplements, and therefore are subjected to a very limited form of regulation, and advertisements normally highlight their potential activities without mentioning any side effect. Also, herbs are generally believed to be 'natural', and hence safe. Many nutritional supplements contains herb compounds usually not present in the diet (e.g. G...
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Development of Safe and Effective Botanical Dietary Supplements.
van Breemen, Richard B
2015-11-12
Regulated differently than drugs or foods, the market for botanical dietary supplements continues to grow worldwide. The recently implemented U.S. FDA regulation that all botanical dietary supplements must be produced using good manufacturing practice is an important step toward enhancing the safety of these products, but additional safeguards could be implemented, and unlike drugs, there are currently no efficacy requirements. To ensure a safe and effective product, botanical dietary supplements should be developed in a manner analogous to pharmaceuticals that involves identification of mechanisms of action and active constituents, chemical standardization based on the active compounds, biological standardization based on pharmacological activity, preclinical evaluation of toxicity and potential for drug-botanical interactions, metabolism of active compounds, and finally, clinical studies of safety and efficacy. Completing these steps will enable the translation of botanicals from the field to safe human use as dietary supplements.
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Development of Safe and Effective Botanical Dietary Supplements
2015-01-01
Regulated differently than drugs or foods, the market for botanical dietary supplements continues to grow worldwide. The recently implemented U.S. FDA regulation that all botanical dietary supplements must be produced using good manufacturing practice is an important step toward enhancing the safety of these products, but additional safeguards could be implemented, and unlike drugs, there are currently no efficacy requirements. To ensure a safe and effective product, botanical dietary supplements should be developed in a manner analogous to pharmaceuticals that involves identification of mechanisms of action and active constituents, chemical standardization based on the active compounds, biological standardization based on pharmacological activity, preclinical evaluation of toxicity and potential for drug–botanical interactions, metabolism of active compounds, and finally, clinical studies of safety and efficacy. Completing these steps will enable the translation of botanicals from the field to safe human use as dietary supplements. PMID:26125082
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12 CFR 225.132 - Acquisition of assets.
2010-01-01
... it constitutes the acquisition, in whole or in part, of a going concern. 2 1 Section 225.4(c)(3) of... Regulation Y, the acquisition of a going concern requires prior Board approval. (c) The following examples... going concern. [39 FR 35128, Sept. 30, 1974, as amended at Reg. Y, 57 FR 28779, June 29, 1992] ...
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77 FR 204 - Federal Acquisition Regulation; Technical Amendments
2012-01-03
... Parts 4, 8, 15, 19, 22, 23, 28, 42, and 52 Government procurement. Dated: December 21, 2011. Laura... paragraph (a)(2) ``http:// www.sba.gov/GC/pcr.html'' and adding ``http://www.sba.gov/content/ procurement-center-representatives'' in its place. PART 22--APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS 22...
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48 CFR 3003.101-3 - Agency regulations.
2010-10-01
....101-3 Section 3003.101-3 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY ACQUISITION REGULATION (HSAR) GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS... Security regulations governing the conduct and responsibilities of employees are contained in 5 CFR part...
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2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Acquisition of commodities... Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE FOOD ASSISTANCE PROGRAMS COMMODITY...) programs. (a) Lowest landed cost and delivery considerations. (1) Except as provided in paragraphs (a)(3...
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Georg Jensen, M; Pedersen, C; Kristensen, M; Frost, G; Astrup, A
2013-02-01
This review provides a critical update on human and animal studies investigating the effect of alginate supplementation on appetite regulation, glycaemic and insulinemic responses, and lipid metabolism with discussion of the evidence on potential mechanisms, efficacy and tolerability. Dependent on vehicle applied for alginate supplementation, the majority of animal and human studies suggest that alginate consumption does suppress satiety and to some extent energy intake. Only one long-term intervention trial found effects on weight loss. In addition, alginates seem to exhibit beneficial influence on postprandial glucose absorption and insulin response in animals and humans. However, alginate supplementation was only found to have cholesterol-lowering properties in animals. Several mechanisms have been suggested for the positive effect observed, which involve delayed gastric emptying, increased viscosity of digesta and slowed nutrient absorption in the small intestine upon alginate gel formation. Despite reasonable efficacy and tolerability from the acute or short-term studies, we still realize there is a critical need for development of optimal alginate types and vehicles as well as studies on further long-term investigation on alginate supplementation in humans before inferring that it could be useful in the management of obesity and the metabolic syndrome. © 2012 The Authors. obesity reviews © 2012 International Association for the Study of Obesity.
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49 CFR 1542.219 - Supplementing law enforcement personnel.
2010-10-01
... 49 Transportation 9 2010-10-01 2010-10-01 false Supplementing law enforcement personnel. 1542.219 Section 1542.219 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY AIRPORT SECURITY Operations § 1542.219 Supplementing law...
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Prohibited Contaminants in Dietary Supplements.
Mathews, Neilson M
With the increasing use of unregulated dietary supplements, athletes are at continued risk from adverse medical events and inadvertent doping. A review of Clinical Key, MEDLINE, and PubMed databases from 2012 to 2017 was performed using search terms, including dietary supplement, contamination, doping in athletes, inadvertent doping, and prohibited substances. The references of pertinent articles were reviewed for other relevant sources. Clinical review. Level 3. Poor manufacturing processes and intentional contamination with many banned substances continue to occur in dietary supplements sold in the United States. Certain sectors, such as weight loss and muscle-building supplements, pose a greater threat because they are more likely to be contaminated. Athletes will continue to be at risk for adverse events and failed doping tests due to contaminated dietary supplements until legislation changes how they are regulated. In the interim, there are several steps that can be taken to mitigate this risk, including improved education of medical staff and athletes and use of third party-certified products.
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48 CFR 1371.101 - Inspection and manner of doing work.
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Inspection and manner of... DEPARTMENT SUPPLEMENTAL REGULATIONS ACQUISITIONS INVOLVING SHIP CONSTRUCTION AND SHIP REPAIR Provisions and Clauses 1371.101 Inspection and manner of doing work. Insert clause 1352.271-70, Inspection and Manner of...
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Raska, David
2014-01-01
This research explores and tests the effect of an innovative performance feedback practice--feedback supplemented with web-based peer benchmarking--through a lens of social cognitive framework for self-regulated learning. The results suggest that providing performance feedback with references to exemplary peer output is positively associated with…
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78 FR 70481 - Federal Acquisition Regulation; Technical Amendments
2013-11-25
... changes to the FAR. List of Subject in 48 CFR Parts 31 and 52 Government procurement. Dated: November 18, 2013. William Clark, Acting Director, Office of Government-Wide Acquisition Policy, Office of... procedures of FAR Part 25. For line items covered by the WTO GPA, the Government will evaluate offers of U.S...
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48 CFR 370.302 - Types of assurances.
2010-10-01
....302 Section 370.302 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES HHS SUPPLEMENTATIONS SPECIAL PROGRAMS AFFECTING ACQUISITION Acquisitions Involving Human Subjects 370.302 Types of...'s current “List of Registered Institutional Review Boards (IRBs)/Independent Ethics Committees (IECs...
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48 CFR 201.109 - Statutory acquisition-related dollar thresholds-adjustment for inflation.
2010-10-01
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Statutory acquisition-related dollar thresholds-adjustment for inflation. 201.109 Section 201.109 Federal Acquisition...-adjustment for inflation. (d) A matrix showing the most recent escalation adjustments of statutory...
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Brown, Amy Christine
2017-09-01
This is the first of five review articles investigating dietary supplements (DS; includes herbs) that now exceed over 50,000 in the Office of Dietary Supplement's "Dietary Supplement Label Database." Four review articles follow summarizing published medical case reports of DS related to liver toxicity, kidney toxicity, heart toxicity, and cancer. The most popular DS were vitamin or mineral supplements (43%) followed by specialty supplements (20%), botanicals (20%; herbs), and sports supplements (16%). The 2013 Annual Report of the American Association of Poison Control Centers revealed 1692 fatalities due to drugs, and zero deaths due to DS. Less than 1 percent of Americans experience adverse events related to DS, and the majority was classified as minor, with many of these related to caffeine, yohimbe, or other stimulant ingredients. The number one adulterant in DS is drugs, followed by New Dietary Ingredients (NDI) not submitted to the FDA - both are illegal and not DS, but rather "tainted products marketed as dietary supplements." The three main categories of DS prone to medical problems are those for sexual enhancement, weight loss, and sports performance/body building. DS are regulated in the U.S. by several federal agencies with overlapping jurisdiction - the Food and Drug Administration (FDA) and the Federal Trade Commission (FTC); enforced by the State Attorneys General Offices (AGO) and Department of Justice (DOJ); and monitored (not regulated) by the Centers for Disease Control and Prevention (CDC). The FDA can remove a DS from the market for phase IV post-marketing surveillance adverse event reports, adulteration (drugs, NDI, synthetic substances), contamination, misidentification, mislabeling or false claims, and not meeting good manufacturing practices (GMP). The FTC and state AGO can also enforce laws against deceptive marketing practices. Suggested improvements to current regulatory requirements are included along with online DS Toxic Tables in the
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7 CFR 1610.7 - Acquisition of certain exchange facilities.
2010-01-01
... Section 1610.7 Agriculture Regulations of the Department of Agriculture (Continued) RURAL TELEPHONE BANK, DEPARTMENT OF AGRICULTURE LOAN POLICIES § 1610.7 Acquisition of certain exchange facilities. In the interest of making optimum use of the Bank's loan funds, a Bank loan for the acquisition of exchange...
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Afsarian, O.; Shahir, M.H.; Akhlaghi, A.; Lotfolahian, H.; Hoseini, A.; Lourens, A.
2016-01-01
An experiment was conducted to evaluate the effects of a periodically low eggshell temperature exposure during incubation and dietary supplementation of arginine on performance, ascites incidence, and cold tolerance acquisition in broilers. A total of 2,400 hatching eggs were randomly assigned to
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Dietary supplements: What's in a name? What's in the bottle?
Marcus, Donald M
2016-01-01
The Dietary Supplement Health and Education Act of 1994 (DSHEA), which arbitrarily classified herbals and other medicinal products as dietary supplements, obscured fundamental differences between two classes of products. Authentic supplements to the diet, such as multivitamins or calcium, have nutritional value and are safe. Herbals are used worldwide as medicines, they do not supplement the diet, they may cause severe adverse events, and they should be regulated as medicines. DSHEA also prevented the Food and Drug Administration (FDA) from effectively regulating herbal supplements as medicines. One consequence of weak FDA regulatory oversight is the poor quality of herbals. FDA inspections of manufacturing facilities have revealed violations of good manufacturing practices in over half of facilities inspected, including unsanitary conditions and lack of product specifications. Moreover, many "all natural" herbals marketed for weight loss, enhancement of sexual health and improving sports performance are adulterated with prescription and over-the-counter medications that have caused adverse cardiovascular events. New procedures to authenticate the identity of plants used in herbals will neither detect adulteration by medications nor provide assurance of appropriate pharmacological activity or safety. Nonvitamin, nonmineral "supplements" should be regulated as medicines, but revision or repeal of DSHEA faces strong opposition in Congress. The marketing of botanical supplements is based on unfounded claims that they are safe and effective. Health professionals need to inform patients and the public that there is no reason to take herbal medicines whose composition and benefits are unknown, and whose risks are evident. Copyright © 2015 John Wiley & Sons, Ltd.
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76 FR 42056 - Department of the Treasury Acquisition Regulation
2011-07-18
... entities. The program is designed for mentoring firms to provide developmental assistance to prot[eacute]g.... Thomas A. Sharpe, Jr., Senior Procurement Executive, Office of the Procurement Executive. Accordingly.... For acquisitions made from non- appropriated funds, the Senior Procurement Executive will determine...
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DEFF Research Database (Denmark)
Knudsen, Michael Helt; Fold, Niels
2010-01-01
Substantial differences in the size of landholdings among cocoa farmers in the Western Region – the last cocoa “frontier” in Ghana – are primarily a result of inheritance practices and the purchase of vast tracts of land by migrants in the initial period of the cocoa boom. Individual accumulation...... surplus from their higher volume of cocoa production into investments in non-farm activities and construction of new residential houses—and not in land acquisition based on market transactions. State regulation of the cocoa sector has spurred increased efficiency among private cocoa purchasing companies...
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2012-09-13
... Trade Organization Government Procurement Agreement (WTO GPA). The Korea Free Trade Agreement now covers acquisition of supplies and services between $100,000 and the current WTO GPA threshold of $202,000. This...'', which is no longer in existence. There is no impact to the Government or small business because this...
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Will the new Consumer Protection Act prevent harm to nutritional supplement users?
Gabriels, Gary; Lambert, Mike; Smith, Pete; Hiss, Donavon
2011-07-25
BACKGROUND. There is no clear distinction between the regulation of food, supplements and medicines in South Africa. Consequently, grey areas exist in implementing the legislation, particularly in the supplement industry. The increase in supplement sales in South Africa can be attributed to aggressive marketing by manufacturers whose claims are not always supported by published peer-reviewed evidence. Such claims often go unchecked, resulting in consumers being mislead about the role of supplements. As a result of poor regulation, contaminants or adulterants in supplements may also cause insidious effects unrelated to the listed ingredients. AIM. To assess the regulations, legislation, and claims associated with nutritional supplement products in South Africa. METHOD. Peer-reviewed literature and the relevant South African statutes were consulted. RESULTS. The National Health Act incorporates the Medicine Control Council, which is charged with ensuring the safety, quality and effectiveness of medicines, and related matters, including complementary/alternative medicines. The South African Institute for Drug-Free Sport and Amendment Act provides for testing athletes for using banned substances, but currently does not concern itself with monitoring nutritional supplements for contaminants or adulterants that may cause a positive drug test, which has implications for sports participants and also the health of the general population. The implementation of the Consumer Protection Act 68 of 2008 (CPA) could protect consumer rights if it is administered and resourced appropriately. CONCLUSION. The CPA should promote greater levels of policy development, regulatory enforcement, and consumer education of South Africa's supplement industry.
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2012-06-29
....gov , including any personal information provided. To confirm receipt of your comment(s), please check... Fiscal Year 2012 (Pub. L. 112- 81). Section 368 requires award of contracts that provide the best value..., public health and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance...
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2012-01-19
... entity referred to in the interim rule is, in essence, the legal entity that signs the contract with the... contractors as defined within the rule and section 866 of the National Defense Authorization Act for Fiscal...
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2011-04-19
... subpart 15.4 currently provides the contracting officer with pricing policy and guidance regarding... from pricing determinations. DoD Response: There is currently sufficient coverage in the FAR to assist contracting officers with making separate commercial and pricing determinations. Contracting officers have the...
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2011-06-29
... under the cost accounting standards prescribed pursuant to section 26 of the Office of Federal... conflict with this rule. There are no known significant alternatives to the rule. Accordingly, DoD does not... pricing data; (2) Exempt from the cost accounting standards under section 26 of the Office of Procurement...
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2013-12-06
.... 13563 emphasizes the importance of quantifying both costs and benefits, of reducing costs, of... WorkFlow Payment Instructions, as prescribed in 232.7004(b). * * * * * PART 232--CONTRACT FINANCING 0 4...
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2013-09-30
...)(xxvi); 0 b. Removing paragraph (f)(xxvii) and redesignating paragraphs (f)(xxviii) through (xxxii) as.... Adding a new paragraph (f)(xxxii); and 0 e. Revising paragraphs (f)(xxxiv) and (xxxv). The revisions and... National Defense Authorization Act for Fiscal Year 2008 (Pub. L. 110-181). * * * * * (xxxii) Use the clause...
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Financial considerations regarding environmental liabilities: Acquisitions and divestitures
International Nuclear Information System (INIS)
Hanson, B.R.
1990-01-01
What position should your company assume in the mining industry? Should your company take a larger or smaller market position? Does it make sense to be acquiring or divesting properties? Should your company be pursuing acquisitions and divestitures simultaneously? The answers to these questions determine in large part what perspective your company will take in assessing and confronting risk of environmental liabilities. From the environmental perspective, serious problems confront the mining industry. Uninformed or misinformed regulators doing a poor job of open-quotes protectingclose quotes the environment continue to plague mining companies at the federal, state and local level. The press and public are routinely ill-informed and often hostile toward mining generally and toward specific projects. The open-quotes not-in-my-backyardclose quotes syndrome continues to haunt projects because every ore-rich plot of land lies in someone's backyard or playground. More profoundly, the industry confronts serious structural impediments caused by media-specific statutes and regulations written with an overriding preference for waste elimination or reduction. Mining and mineral production impact all media and result in an highly integrated project. Despite media-specific statutes and regulations that prefer wastes go anywhere but in their particular media, mine wastes must go somewhere. To its credit, the mining industry has persevered in the face of complex and often conflicting environmental statutes and regulations. The industry has continued to expand or contract in response to market conditions. Companies must continue to pursue acquisitions and divestitures based on their position and goals. This paper addresses financial risks in acquisitions and divestitures and, more importantly, suggests strategies to limit environmental liabilities during acquisitions and divestitures
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DEFF Research Database (Denmark)
Reitelseder, Søren; Agergaard, Jakob; Doessing, Simon
2014-01-01
Purpose Resistance exercise and amino acid availability are positive regulators of muscle protein net balance (NB). However, anabolic responses to resistance exercise and protein supplementation deserve further elucidation. The purpose was to compare intakes of whey, caseinate (both: 0.30 g/kg lean...... body mass), or a non-caloric control after heavy resistance exercise on protein turnover and mRNA expressions of forkhead homeobox type O (FOXO) isoforms, muscle RING finger 1 (MuRF1), and Atrogin1 in young healthy males. Methods Protein turnover was determined by stable isotope-labeled leucine...
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76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Technical Amendments
2011-05-11
...; facsimile 703-602-0350. SUPPLEMENTARY INFORMATION: This final rule amends DFARS by adding language at 225... considerations when supporting contingency operations. The rule also adds language and a new subpart at 225.78... the geographic combatant commander, which may include support such as military exercises/training...
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77 FR 31536 - Defense Federal Acquisition Regulation Supplement; Technical Amendments
2012-05-29
... interim rule amends DFARS part 252 to implement the United States- Colombia Trade Promotion Agreement Implementation Act (Pub. L. 112-42) (19 U.S.C. 3805 note) by adding Colombia to the definition of ``Free Trade...--SOLICITATION PROVISIONS AND CONTRACT CLAUSES 0 1. The authority citation for 48 CFR part 252 continues to read...
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76 FR 76318 - Defense Federal Acquisition Regulation Supplement; Technical Amendments
2011-12-07
... Defense Business Transformation Agency Contracting Office. PART 204--ADMINISTRATIVE MATTERS 204.402...) * * * (iii) For special notices for small business events, follow the procedures at PGI 205.207(d)(ii). PART... Economy Act order. PART 219--SMALL BUSINESS PROGRAMS 0 22. Section 219.202-1 is added to read as follows...
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78 FR 13543 - Defense Federal Acquisition Regulation Supplement; Technical Amendments
2013-02-28
..., 204, 215, 225, 227, 242, 245 and 252 Government procurement. Manuel Quinones, Editor, Defense...) shall be conducted only when-- (i) A contractor has $50 million of qualifying sales to the Government... circumstance(s) may result in a material impact on Government contract costs: (1) Information or data reveals a...
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76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Technical Amendment
2011-05-11
... procurement programs, it must provide written notice of the determination to the GSA Suspension and Debarment Official. List of Subjects in 48 CFR Part 209 Government procurement. Ynette R. Shelkin, Editor, Defense... suspended from procurement programs, it must provide written notice of the determination to the General...
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77 FR 76936 - Defense Federal Acquisition Regulation Supplement; Technical Amendments
2012-12-31
...; List of Subjects in 48 CFR Parts 201, 203, 204, 215, 219, 245, and 252 Government procurement. Manuel... clause 52.203-13, Contractor Code of Business Ethics and Conduct, is the DoD Office of Inspector General...
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77 FR 52253 - Defense Federal Acquisition Regulation Supplement; Technical Amendments
2012-08-29
...-7017(a) to add Armenia to the definition of ``Designated country'', which was inadvertently omitted... other limitations on their use. * * * * * PART 230--COST ACCOUNTING STANDARDS ADMINISTRATION 0 7. The...) definition of ``Designated country'' at paragraph (i) by adding the country of Armenia within the parentheses...
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Defense Acquisition Reform, 19602009: An Elusive Goal
2011-10-31
the seven largest economies of the world (United States, China, Japan, Germany, France, United Kingdom, and Italy ).11 Major weapon systems...the Federal Acquisition Regulation.96 95 Ibid., pp. 20, 21. 96 Joseph Ferrara , “DoD’s 5000 Documents: Evolution and Change in Defense Acquisition...Wayne Smith. How Much Is Enough: Shaping the Defense Program, 1961–1969. New York: Harper & Row, 1971. Ferrara , Joseph. “DoD’s 5000 Documents
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Augmented kinematic feedback from haptic virtual reality for dental skill acquisition.
Suebnukarn, Siriwan; Haddawy, Peter; Rhienmora, Phattanapon; Jittimanee, Pannapa; Viratket, Piyanuch
2010-12-01
We have developed a haptic virtual reality system for dental skill training. In this study we examined several kinds of kinematic information about the movement provided by the system supplement knowledge of results (KR) in dental skill acquisition. The kinematic variables examined involved force utilization (F) and mirror view (M). This created three experimental conditions that received augmented kinematic feedback (F, M, FM) and one control condition that did not (KR-only). Thirty-two dental students were randomly assigned to four groups. Their task was to perform access opening on the upper first molar with the haptic virtual reality system. An acquisition session consisted of two days of ten trials of practice in which augmented kinematic feedback was provided for the appropriate experimental conditions after each trial. One week after, a retention test consisting of two trials without augmented feedback was completed. The results showed that the augmented kinematic feedback groups had larger mean performance scores than the KR-only group in Day 1 of the acquisition and retention sessions (ANOVA, p0.05). The trends in acquisition and retention sessions suggest that the augmented kinematic feedback can enhance the performance earlier in the skill acquisition and retention sessions.
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Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia
Directory of Open Access Journals (Sweden)
Nick D. Pokorzynski
2017-09-01
Full Text Available The obligate intracellular pathogen Chlamydia trachomatis, along with its close species relatives, is known to be strictly dependent upon the availability of iron. Deprivation of iron in vitro induces an aberrant morphological phenotype termed “persistence.” This persistent phenotype develops in response to various immunological and nutritional insults and may contribute to the development of sub-acute Chlamydia-associated chronic diseases in susceptible populations. Given the importance of iron to Chlamydia, relatively little is understood about its acquisition and its role in gene regulation in comparison to other iron-dependent bacteria. Analysis of the genome sequences of a variety of chlamydial species hinted at the involvement of unconventional mechanisms, being that Chlamydia lack many conventional systems of iron homeostasis that are highly conserved in other bacteria. Herein we detail past and current research regarding chlamydial iron biology in an attempt to provide context to the rapid progress of the field in recent years. We aim to highlight recent discoveries and innovations that illuminate the strategies involved in chlamydial iron homeostasis, including the vesicular mode of acquiring iron from the intracellular environment, and the identification of a putative iron-dependent transcriptional regulator that is synthesized as a fusion with a ABC-type transporter subunit. These recent findings, along with the noted absence of iron-related homologs, indicate that Chlamydia have evolved atypical approaches to the problem of iron homeostasis, reinvigorating research into the iron biology of this pathogen.
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Athletes and Supplements: Prevalence and Perspectives.
Garthe, Ina; Maughan, Ronald J
2018-03-01
In elite sport, where opponents are evenly matched, small factors can determine the outcome of sporting contests. Not all athletes know the value of making wise nutrition choices, but anything that might give a competitive edge, including dietary supplements, can seem attractive. Between 40% and 100% of athletes typically use supplements, depending on the type of sport, level of competition, and the definition of supplements. However, unless the athlete has a nutrient deficiency, supplementation may not improve performance and may have a detrimental effect on both performance and health. Dietary supplements are classified as a subcategory of food, so manufacturers are not required to provide evidence of product safety and efficacy, nor obtain approval from regulatory bodies before marketing supplements. This creates the potential for health risks, and serious adverse effects have been reported from the use of some dietary supplements. Athletes who compete in sports under an anti-doping code must also realize that supplement use exposes them to a risk of ingesting banned substances or precursors of prohibited substances. Government systems of regulations do not include specific laboratory testing for banned substances according to the WADA list, so a separate regulatory framework to evaluate supplements for their risk of provoking a failed doping test is needed. In the high-performance culture typical of elite sport, athletes may use supplements regardless of possible risks. A discussion around medical, physiological, cultural, and ethical questions may be warranted to ensure that the athlete has the information needed to make an informed choice.
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2010-09-29
...). Section 615 authorizes exemption from the Buy American Act for acquisition of information technology that... acquisition of information technology that is a commercial item. This same exemption has appeared every year... applies. ``Information technology'' and ``Commercial item'' are already defined in FAR part 2. This is a...
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Thyroxine and triiodothyronine content in commercially available thyroid health supplements.
Kang, Grace Y; Parks, Jonathan R; Fileta, Bader; Chang, Audrey; Abdel-Rahim, Maged M; Burch, Henry B; Bernet, Victor J
2013-10-01
As defined by the Dietary Supplement Health and Education Act 1997, such substances as herbs and dietary supplements fall under general Food and Drug Administration supervision but have not been closely regulated to date. We examined the thyroid hormone content in readily available dietary health supplements marketed for "thyroid support." Ten commercially available thyroid dietary supplements were purchased. Thyroid supplements were dissolved in 10 mL of acetonitrile and water with 0.1% trifloroacetic acid and analyzed using high-performance liquid chromatography for the presence of both thyroxine (T4) and triiodothyronine (T3) using levothyroxine and liothyronine as a positive controls and standards. The amount of T4 and T3 was measured separately for each supplement sample. Nine out of 10 supplements revealed a detectable amount of T3 (1.3-25.4 μg/tablet) and 5 of 10 contained T4 (5.77-22.9 μg/tablet). Taken at the recommended dose, 5 supplements delivered T3 quantities of greater than 10 μg/day, and 4 delivered T4 quantities ranging from 8.57 to 91.6 μg/day. The majority of dietary thyroid supplements studied contained clinically relevant amounts of T4 and T3, some of which exceeded common treatment doses for hypothyroidism. These amounts of thyroid hormone, found in easily accessible dietary supplements, potentially expose patients to the risk of alterations in thyroid levels even to the point of developing iatrogenic thyrotoxicosis. The current study results emphasize the importance of patient and provider education regarding the use of dietary supplements and highlight the need for greater regulation of these products, which hold potential danger to public health.
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78 FR 31551 - Federal Acquisition Regulation; Submission for OMB Review; Commerce Patent Regulations
2013-05-24
...; Submission for OMB Review; Commerce Patent Regulations AGENCIES: Department of Defense (DOD), General... collection requirement concerning Department of Commerce patent regulations. A notice was published in...- 0095, Commerce Patent Regulations, by any of the following methods: Regulations.gov : http://www...
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41 CFR 109-26.501-53 - Acquisitions by transfer.
2010-07-01
... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Acquisitions by transfer. 109-26.501-53 Section 109-26.501-53 Public Contracts and Property Management Federal Property Management Regulations System (Continued) DEPARTMENT OF ENERGY PROPERTY MANAGEMENT REGULATIONS SUPPLY AND...
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77 FR 43083 - Federal Acquisition Regulation; Information Collection; Advance Payments
2012-07-23
...; Information Collection; Advance Payments AGENCIES: Department of Defense (DOD), General Services... requirement concerning advance payments. Public comments are particularly invited on: Whether this collection of information is necessary for the proper performance of functions of the Federal Acquisition...
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78 FR 23199 - NASA FAR Supplement Regulatory Review No. 1
2013-04-18
... 2700-AE01 NASA FAR Supplement Regulatory Review No. 1 AGENCY: National Aeronautics and Space Administration. ACTION: Proposed rule. SUMMARY: NASA is updating the NASA FAR Supplement (NFS) with the goal of... existing regulations. The revisions to this rule are part of NASA's retrospective plan under EO 13563...
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Directory of Open Access Journals (Sweden)
Jian Guan
2015-06-01
Full Text Available We have previously reported that the supplementation of ganglioside-enriched complex-milk-lipids improves cognitive function and that a phospholipid-enriched complex-milk-lipid prevents age-related cognitive decline in rats. This current study evaluated the effects of post-natal supplementation of ganglioside- and phospholipid-enriched complex-milk-lipids beta serum concentrate (BSC on cognitive function in young rats. The diet of male rats was supplemented with either gels formulated BSC (n = 16 or blank gels (n = 16 from post-natal day 10 to day 70. Memory and anxiety-like behaviors were evaluated using the Morris water maze, dark–light boxes, and elevated plus maze tests. Neuroplasticity and white matter were measured using immunohistochemical staining. The overall performance in seven-day acquisition trials was similar between the groups. Compared with the control group, BSC supplementation reduced the latency to the platform during day one of the acquisition tests. Supplementation improved memory by showing reduced latency and improved path efficiency to the platform quadrant, and smaller initial heading error from the platform zone. Supplemented rats showed an increase in striatal dopamine terminals and hippocampal glutamate receptors. Thus BSC supplementation during post-natal brain development improved learning and memory, independent from anxiety. The moderately enhanced neuroplasticity in dopamine and glutamate may be biological changes underlying the improved cognitive function.
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15 CFR Supplement 1 to Part 732 - Decision Tree
2010-01-01
... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Decision Tree 1 Supplement 1 to Part 732 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU... THE EAR Pt. 732, Supp. 1 Supplement 1 to Part 732—Decision Tree ER06FE04.000 [69 FR 5687, Feb. 6, 2004] ...
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75 FR 21508 - Health and Human Services Acquisition Regulation; Corrections
2010-04-26
..., Federal appropriations law, and green purchasing training requirements, including completion of refresher... law, and green purchasing training requirements, including completion of refresher training. If the... defined in FAR 17.103, is limited to individual acquisitions where the full estimated cancellation ceiling...
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2017-11-01
Each subcontract required non- disclosure agreements (NDAs) with the prime. 5 2. Flow-Down Clauses FAR/DFARS flow-down clauses derive from the...unusual for the prime contractor to only account for 10–20 percent of the total MDAP cost. Subcontractors—inclusive of basic parts and material suppliers...that feed the upper tiers of the supply chain— account for the bulk of the defense industrial base.7 MDAP prime contractors are often viewed as
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77 FR 12933 - Federal Acquisition Regulation: Trade Agreements Thresholds
2012-03-02
... $202,000 $202,000 $7,777,000 FTAs: Australia FTA 77,494 77,494 7,777,000 Bahrain FTA 202,000 202,000 10...: --Canada 25,000 77,494 10,074,262 --Mexico 77,494 77,494 10,074,262 Oman FTA 202,000 202,000 10,074,262...,000'' and adding ``$202,000'' in its place. PART 25--FOREIGN ACQUISITION 25.202 [Amended] 0 3. Amend...
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78 FR 80379 - Federal Acquisition Regulation; Trade Agreements Thresholds
2013-12-31
... $204,000 $7,864,000 FTAs: Australia FTA 79,507 79,507 7,864,000 Bahrain FTA 204,000 204,000 10,335,931...,000 7,864,000 Morocco FTA 204,000 204,000 7,864,000 NAFTA: --Canada 25,000 79,507 10,335,931 --Mexico... adding ``$204,000'' in its place. PART 25--FOREIGN ACQUISITION 25.202 [Amended] 0 5. Amend section 25.202...
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Zhou, Shuang-jiang; Xue, Li-fen; Wang, Xue-yi; Jiang, Wen-gao; Xue, Yan-xue; Liu, Jian-feng; He, Yin-yin; Luo, Yi-xiao; Lu, Lin
2012-05-01
Accumulating clinical and preclinical studies have shown that the memories of the rewarding effects of drugs and their paired cues may contribute to relapse and persistent cocaine use. Glutaminergic actions in the ventral tegmental area (VTA) have been shown to regulate the rewarding effect of drugs and conditioned responses to drug-associated cues, but the role of the VTA in the acquisition, retrieval, and reconsolidation of cocaine cues is not yet known. In the present study, we used 7-chlorothiokynurenic acid (7-CTKA), an N-methyl-D-aspartate (NMDA) receptor glycine modulatory site antagonist with no rewarding effects, to examine the role of the NMDA receptor glycine modulatory site in the acquisition, retrieval, and reconsolidation of cocaine-related reward memory using the conditioned place preference (CPP) paradigm. Separate groups of Sprague-Dawley rats were trained to acquire cocaine-induced CPP. Vehicle or 7-CTKA was microinjected into the VTA or substantia nigra (SN) (5 μg/μl) at different time points: 10 min before each CPP training session (acquisition), 10 min before the reactivation of CPP (retrieval), and immediately after the reactivation of CPP (reconsolidation). Cocaine-induced CPP was retested 24 h and 1 and 2 weeks after 7-CTKA administration. 7-CTKA microinjected into the VTA, but not SN, significantly impaired the acquisition, retrieval, and reconsolidation of cocaine-induced CPP without affecting cocaine-induced locomotion. Our findings suggest that the NMDA receptor glycine modulatory site in the VTA plays a major role in cocaine reward memory, and NMDA receptor glycine site antagonists may be potential pharmacotherapies for the management of relapse.
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Identification of the heme acquisition system in Vibrio vulnificus M2799.
Kawano, Hiroaki; Miyamoto, Katsushiro; Yasunobe, Megumi; Murata, Masahiro; Yamahata, Eri; Yamaguchi, Ryo; Miyaki, Yuta; Tsuchiya, Takahiro; Tanabe, Tomotaka; Funahashi, Tatsuya; Tsujibo, Hiroshi
2018-04-01
Vibrio vulnificus, the causative agent of serious, often fatal, infections in humans, requires iron for its pathogenesis. As such, it obtains iron via both vulnibactin and heme-mediated iron-uptake systems. In this study, we identified the heme acquisition system in V. vulnificus M2799. The nucleotide sequences of the genes encoding heme receptors HupA and HvtA and the ATP-binding cassette (ABC) transport system proteins HupB, HupC, and HupD were determined, and then used in the construction of deletion mutants developed from a Δics strain, which could not synthesize vulnibactin. Growth experiments using these mutants indicated that HupA and HvtA are major and minor heme receptors, respectively. The expressions of two proteins were analyzed by the quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). Furthermore, complementation analyses confirmed that the HupBCD proteins are the only ABC transport system shared by both the HupA and HvtA receptors. This is the first genetic evidence that the HupBCD proteins are essential for heme acquisition by V. vulnificus. Further investigation showed that hupA, hvtA, and hupBCD are regulated by Fur. The qRT-PCR analysis of the heme receptor genes revealed that HupR, a LysR-family positive transcriptional activator, upregulates the expression of hupA, but not hvtA. In addition, ptrB was co-transcribed with hvtA, and PtrB had no influence on growth in low-iron CM9 medium supplemented with hemin, hemoglobin, or cytochrome C. Copyright © 2018 Elsevier Ltd. All rights reserved.
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Proteomics in quality control: Whey protein-based supplements.
Garrido, Bruno Carius; Souza, Gustavo H M F; Lourenço, Daniela C; Fasciotti, Maíra
2016-09-16
The growing consumption of nutritional supplements might represent a problem, given the concern about the quality of these supplements. One of the most used supplements is whey protein (WP); because of its popularity, it has been a target of adulteration with substitute products, such as cheaper proteins with lower biological value. To investigate this type of adulteration, this study used shotgun proteomics analyses by MS(E) (multiplexed, low- and high-collision energy, data-independent acquisition) of WP-based supplements. Seventeen WP-based supplement samples were evaluated. Chicken, maize, rice, potato, soybean, and wheat proteins were considered as probable sources of bovine whey adulteration. Collectively, 523 proteins were identified across all 16 samples and replicates, with 94% of peptides inside a normal distribution within 10ppm of maximum error. In 10 of the 16 samples analyzed, only proteins from bovine whey could be detected, while in the other samples several other protein sources were detected in high concentrations, especially soybean, wheat, and rice. These results point out a probable adulteration and/or sample contamination during manufacturing that could only be detected using this proteomic approach. The present work shows how shotgun proteomics can be used to provide reliable answers in quality control matters, especially focusing on Whey Protein nutritional supplements which are a very popular subject in food and nutrition. In order to achieve an appropriate methodology, careful evaluation was performed applying extremely rigorous quality criteria, established for the proteomic analysis. These criteria and the methodological approach used in this work might serve as a guide for other authors seeking to use proteomics in quality control. Copyright © 2016 Elsevier B.V. All rights reserved.
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Use of Federal Acquisition Regulation. Part 12. Contracts for Applied Research
National Research Council Canada - National Science Library
2001-01-01
...) Part 12, "Acquisition of Commercial Items,"contracts for acquiring applied research. Applied research involves the scientific efforts to translate basic research into solutions for broadly defined military needs...
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2010-04-08
... for billboards for a total of $73 million. DoD has a relatively small role in the overall U.S. economy... significantly the intended boost to the Iraqi and Afghani industrial base. 2. Concern for the Industrial Base of...
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41 CFR 101-1.108 - Agency implementation and supplementation of FPMR.
2010-07-01
... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Agency implementation and supplementation of FPMR. 101-1.108 Section 101-1.108 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation...
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10 CFR 51.92 - Supplement to the final environmental impact statement.
2010-01-01
... 10 Energy 2 2010-01-01 2010-01-01 false Supplement to the final environmental impact statement. 51...-Regulations Implementing Section 102(2) Final Environmental Impact Statements-General Requirements § 51.92 Supplement to the final environmental impact statement. (a) If the proposed action has not been taken, the...
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Travieso, John; Harbin, Samuel; Harper, Lynn; Christianson, Ann; Coombs, John; Ingram, Pat; Herring, Larry; George, Jennifer; Ward, Richard; Terrell, Vaneada; Harris, Mark; Gaudio, Lou; Peate, Mary Clare; Yoder, Cory; Obata, Michelle
2010-01-01
This handbook provides a pocket-sized guide to help you meet the needs of those whom you are supporting. This is crucial to your success and that of the overall mission. It is by no means a stand-alone document and must be read together with the Federal Acquisition Regulation, the Defense Federal Acquisition Regulation Supplement, and Operational Contract Support in Joint Operations (Joint Publication 4-10).
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7 CFR 4280.29 - Supplemental financing required for the Ultimate Recipient Project.
2010-01-01
... 7 Agriculture 15 2010-01-01 2010-01-01 false Supplemental financing required for the Ultimate Recipient Project. 4280.29 Section 4280.29 Agriculture Regulations of the Department of Agriculture... AND GRANTS Rural Economic Development Loan and Grant Programs § 4280.29 Supplemental financing...
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48 CFR 1.109 - Statutory acquisition-related dollar thresholds-adjustment for inflation.
2010-10-01
...-related dollar thresholds-adjustment for inflation. 1.109 Section 1.109 Federal Acquisition Regulations..., Issuance 1.109 Statutory acquisition-related dollar thresholds—adjustment for inflation. (a) 41 U.S.C. 431a... the FAR for inflation, except as provided in paragraph (c) of this section. This adjustment is...
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Spindle assembly checkpoint acquisition at the mid-blastula transition.
Directory of Open Access Journals (Sweden)
Maomao Zhang
Full Text Available The spindle assembly checkpoint (SAC maintains the fidelity of chromosome segregation during mitosis. Nonpathogenic cells lacking the SAC are typically only found in cleavage stage metazoan embryos, which do not acquire functional checkpoints until the mid-blastula transition (MBT. It is unclear how proper SAC function is acquired at the MBT, though several models exist. First, SAC acquisition could rely on transcriptional activity, which increases dramatically at the MBT. Embryogenesis prior to the MBT relies primarily on maternally loaded transcripts, and if SAC signaling components are not maternally supplied, the SAC would depend on zygotic transcription at the MBT. Second, checkpoint acquisition could depend on the Chk1 kinase, which is activated at the MBT to elongate cell cycles and is required for the SAC in somatic cells. Third, SAC function could depend on a threshold nuclear to cytoplasmic (N:C ratio, which increases during pre-MBT cleavage cycles and dictates several MBT events like zygotic transcription and cell cycle remodeling. Finally, the SAC could by regulated by a timer mechanism that coincides with other MBT events but is independent of them. Using zebrafish embryos we show that SAC acquisition at the MBT is independent of zygotic transcription, indicating that the checkpoint program is maternally supplied. Additionally, by precociously lengthening cleavage cycles with exogenous Chk1 activity, we show that cell cycle lengthening and Chk1 activity are not sufficient for SAC acquisition. Furthermore, we find that SAC acquisition can be uncoupled from the N:C ratio. Together, our findings indicate that SAC acquisition is regulated by a maternally programmed developmental timer.
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Sahin, Kazim; Tuzcu, Mehmet; Orhan, Cemal; Agca, Can A; Sahin, Nurhan; Guvenc, Mehmet; Krejpcio, Zbigniew; Staniek, Halina; Hayirli, Armagan
2011-11-01
Conditions in which glucose metabolism is impaired due to insulin resistance are associated with memory impairment. It was hypothesized that supplemental chromium (Cr) may alleviate insulin resistance in type 2 diabetes and consequently improve memory acquisition, depending upon its source and level. In a complete randomized design experiment, male Wistar rats (n=60; weighing 200-220 g) were fed either normal (8%, normal diet (ND)) or high-fat (40%, high-fat diet (HFD)) diet and supplemented with Cr as either chromium-glycinate (CrGly) or chromium-acetate (CrAc) at doses of 0, 40, or 80 μg/kg body weight (BW) via drinking water from 8 to 20 weeks of age. Feeding HFD induced type 2 diabetes, as reflected by greater glucose/insulin ratio (2.98 vs. 2.74) comparing to feeding ND. Moreover, HFD rats had greater BW (314 vs. 279 g) and less serum (53 vs. 68 μg/L) and brain (14 vs. 24 ng/g) Cr concentrations than ND rats. High-fat diet caused a 32% reduction in expressions of glucose transporters 1 and 3 (GLUTs) in brain tissue and a 27% reduction in mean percentage time spent in the target quadrant and a 38% increase in spatial memory acquisition phase (SMAP) compared with ND. Compared with supplemental Cr as CrAc, CrGly was more effective to ameliorate response variables (i.e., restoration of tissue Cr concentration, enhancement of cerebral GLUTs expressions, and reduction of the glucose/insulin ratio and SMAP) in a dose-response manner, especially in rats fed HFD. Supplemental Cr as CrGly may have therapeutic potential to enhance insulin action and alleviate memory acquisition in a dose-dependent manner, through restoring tissue Cr reserve and enhancing cerebral GLUTs expressions.
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7 CFR 246.10 - Supplemental foods.
2010-01-01
... 7 Agriculture 4 2010-01-01 2010-01-01 false Supplemental foods. 246.10 Section 246.10 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... nutritional needs of the participant. The food packages are as follows: (1) Food Package I—Infants birth...
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An overview of data acquisition, signal coding and data analysis techniques for MST radars
Rastogi, P. K.
1986-01-01
An overview is given of the data acquisition, signal processing, and data analysis techniques that are currently in use with high power MST/ST (mesosphere stratosphere troposphere/stratosphere troposphere) radars. This review supplements the works of Rastogi (1983) and Farley (1984) presented at previous MAP workshops. A general description is given of data acquisition and signal processing operations and they are characterized on the basis of their disparate time scales. Then signal coding, a brief description of frequently used codes, and their limitations are discussed, and finally, several aspects of statistical data processing such as signal statistics, power spectrum and autocovariance analysis, outlier removal techniques are discussed.
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Mergers and acquisitions: Guidelines for consideration by state public utility commissions
Energy Technology Data Exchange (ETDEWEB)
Graniere, R.J.; Burns, R.E.
1996-11-01
This is the first of a series of reports on utility mergers and acquisitions published by NRRI; because it was completed Nov. 1996, it does not cover FERC Order 592 (policy statement on merger policy under Federal Power Act). Since cost-benefit analyses are expensive, state regulators need guidelines that efficiently streamline the review process for mergers and acquisitions. Purpose of this paper is to suggest such guidelines; they are applicable only to mergers and acquisitions of vertically integrated electric utilities or combination electric/gas utilities.
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76 FR 64902 - Defense Federal Acquisition Regulation Supplement; Ownership of Offeror
2011-10-19
... the ability to understand the corporate structure and affiliations of its suppliers. DoD is seeking... dialogue with industry and Government agencies about developing a method by which offerors, if owned or controlled by another business entity, can identify to DoD the Commercial and Government Entity (CAGE) code...
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2011-11-28
... information collection requires contractors to comply with the notification process at DFARS clause 252.204... purposes. The U.S.-IAEA Additional Protocol permits the United States unilaterally to declare exclusions from inspection requirements for activities with direct national security significance. The clause at...
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An empirical investigation on factors influencing export of herbal supplements
Directory of Open Access Journals (Sweden)
Nazanin Hajmirzahosseini Yazdi
2014-02-01
Full Text Available During the past few years, there have been growing interests in business development of herbal supplements in many developing countries especially in Iran. Herbal supplements are used to cure many deceases such as medicating anxiety, acne, weight loss, depression, etc. In this paper, we present an empirical investigation to detect important factors influencing exporting herbal supplements. The proposed study designs a questionnaire consists of 31 questions, distributes it among 210 experts who are professional in the area of production and distribution of herbal supplements and using factor analysis, the study detects eight factors including supportive laws and regulations, organizational atmosphere, marketing structure, knowledge oriented, feasibility study, research and development, competitive strategy and partnership strategies.
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[Labeling of vitamin and mineral supplements: a revision of the federal normative regulations].
de Carvalho, Patricia Borges; Araújo, Wilma Maria Coelho
2008-04-01
In Brazil, there is a steadily increasing offer and demand for products on the basis of vitamins and minerals. According to Brazilian law, the differences in the dosages offered to the consumer in each product are the parameter for its classification as alimentary supplement or medicament. The limit between these two concepts, however, is confusing and lacks clearness. Considering the risk posed by imprudent consumption of such products and seeking to facilitate the interpretation and consolidation of the norms dealing with vitamin and mineral products as well as to create the basis for a master's degree dissertation, a bibliographical survey and evaluation of the entire juridical basis regarding the labeling of these products was conducted. It was concluded that the normative regulations are extensive, complex and of difficult understanding, with a great number of norms dealing with the same subject issued by different authorities. These norms are not consolidated leading to difficult interpretation by retailers, health professionals and consumers and even to failures in the application of these norms by the control authorities. Suggestions are made for helping to correct the failures identified in the study.
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The importance of partnerships, mergers and acquisitions
Energy Technology Data Exchange (ETDEWEB)
Trabandt, C.A. [Merrill Lynch, New York, NY (United States)
1998-09-01
An overview of the electric utility industry was presented. The main factors driving mergers and acquisitions in the industry were identified as being consolidation, disaggregation, convergence and international expansion. To prove the point, statistics from recent merger and acquisition transactions in the U.S. were presented. The importance of disaggregation of the utility business and convergence as the major themes of the electricity and natural gas industries were demonstrated. They are driven by a new competitive marketplace and fewer regulations. The driving forces behind them were explained, buttressing the arguments with recent statistics reflecting an upsurge in convergence transactions. Significant opportunities abroad and recent foreign acquisitions by U. S. utilities were also reviewed. With regard to convergence, it was shown to be occurring in both the generation/wholesale and distribution/retail marketing segment of the electric power industry. 3 figs.
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AN OVERVIEW ON THE DETERMINANTS OF MERGERS AND ACQUISITIONS WAVES
Directory of Open Access Journals (Sweden)
Vancea Mariana
2012-12-01
Full Text Available This paper concentrates on the presentation of the economic dimension of the mergers and acquisitions from a macroeconomic perspective. Thus, the objective of this paper is to reveal the main drivers of merger and acquisition activity. These operations take place in waves, which enters the context of changing the competition game marked by economic changes, technological evolutions, changes generated by the phenomenon of globalization, and by regulating changes. On the other side, a series of studies in the literature argue the existence of a connection between evaluating the securities and the merger and acquisition activity. This research is based on a systematic, logical and comparative analysis of scientific literature regarding the macroeconomic determinants of mergers and acquisitions.
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2012-07-23
... provided. FOR FURTHER INFORMATION CONTACT: Mr. Michael Jackson, Procurement Analyst, Office of Governmentwide Acquisition Policy, (202) 208-4949 or email michaelo.jackson@gsa.gov . SUPPLEMENTARY INFORMATION...
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12 CFR 225.107 - Acquisition of stock in small business investment company.
2010-01-01
...) of the Act makes it unlawful for a bank to invest any of its funds in the capital stock of any other... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Acquisition of stock in small business...) Regulations Financial Holding Companies Interpretations § 225.107 Acquisition of stock in small business...
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48 CFR 3053.222-70 - Application of labor laws to Government acquisitions.
2010-10-01
... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Application of labor laws... Prescription of Forms 3053.222-70 Application of labor laws to Government acquisitions. The following form is prescribed for use in connection with the application of labor laws, as specified in (HSAR) 48 CFR 3022.406-9...
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48 CFR 252.225-7016 - Restriction on acquisition of ball and roller bearings.
2010-10-01
... of ball and roller bearings. 252.225-7016 Section 252.225-7016 Federal Acquisition Regulations System... and roller bearings. As prescribed in 225.7009-5, use the following clause: Restriction on Acquisition of Ball and Roller Bearings (MAR 2006) (a) Definitions. As used in this clause' (1) Bearing...
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Health claims made on multivitamin and mineral supplements
Directory of Open Access Journals (Sweden)
Jelena Jovičić
2011-12-01
Full Text Available Introduction: Basic purpose of health claims is consumers' benefit by providing information about healthy eating habits. It is necessary for health claims to be scientifically substantiated and truthful. Health claims should not attribute to food the property of preventing, treating or curing a human disease. Use of health claims should be followed by a statement indicating the importance of a varied and balanced diet and a healthy lifestyle. The objective of this research was to examine the compliance of health claims made on multivitamin and mineral dietary supplements' labels on the Serbian market with national regulation concerning health safety of dietary products.Methods: An assessment of labels of MVMs was done in two privately owned pharmacies in Novi Sad, Serbia in August 2010.Results: In total, 48 MVMs were sampled and 22 health claims were detected. Seven out of 22 health claims were in compliance with the national regulation. The main reason for health claims on foreign MVMs not to be compliant with the regulation in Serbia was inadequate or nonexistent translation of original labels.Conclusion: Detected use of terms such as "prevention", "treatment" and "indications" on vitamin and mineral dietary supplements' labels is both forbidden and misleading to consumers. Coupled with inadequate or nonexistent translation of the labels, it leads to a low level of protection of Serbian consumers. It is necessary to establish an effective monitoring system for dietary supplements' labeling on a national scale in order toprotect consumers and their wellbeing.
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Future Trends: Nutritional Supplements in Sports and Exercise
Spano, Marie; Antonio, Jose
The field of sports nutrition is defined not only by dietary recommendations for various athletes, research and new supplements that are on store shelves but also by the direction of the industry itself. Consumer spending, media coverage, professional athlete endorsement of various supplements, lawsuits, regulations in governing bodies and clinical research all have an impact on the direction and growth of the sports nutrition industry. To date, no supplement has affected sports nutrition as much as creatine and the company that both funded most of the research supporting the ergogenic benefits of creatine and capitalized on such research. There is no current leader in the sports nutrition market. Instead, companies are vying among steady competition for space on store shelves and overall product sales.
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Vitamin A supplementation and risk of atopy
DEFF Research Database (Denmark)
Kiraly, Nicholas; Balde, Aliu; Lisse, Ida Marie
2013-01-01
The World Health Organization recommends high-dose vitamin A supplementation (VAS) for children above six months of age in low-income countries. VAS has been associated with up-regulation of the Th2 response. We aimed to determine if VAS is associated with atopy in childhood....
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Equine dietary supplements: an insight into their use and perceptions in the Irish equine industry.
Murray, J M D; Hanna, E; Hastie, P
2018-01-01
Nutritional supplements are frequently used by horse owners/caregivers to supplement their horse(s) diets. Some work has been done to identify the types of supplements fed and the reasons for doing so; however, this has been predominantly disciple-specific and with little focus on participants' perceptions of supplement testing and regulation. The aim of this study was to gain an insight into the use and perceptions of equine dietary supplements in the Irish equestrian industry. An online survey was designed to ascertain the following information: demographics, types of supplements fed and reasons for use, factors that influenced respondents' choice of supplement, where advice was sought and perceptions of testing and regulation of equine supplements. The survey yielded 134 responses, 70% non-professionals and 30% professionals. A greater percentage of professionals included supplements in their horse(s) diets (98%) compared to non-professionals (86%). Almost 70% of professionals fed more than two supplements, whereas 80% of non-professionals reported to feed only one supplement. Joint supplements were most commonly fed by all respondents (22%) followed by calming supplements (13%). The enhancement of performance (35%) and prevention of joint disorders (34%) were the most common reasons reported by respondents for using a supplement. Over 53% of respondents sought advice on choosing a supplement from their feed merchant, followed by their veterinarian (46%). Veterinary recommendation was given as the most influential factor when choosing a supplement by 90% of respondents, followed by cost (69%). Most (93%) respondents thought that feed supplements had to meet legal standards, with each batch analysed for quality (72%) and the supplement tested on horses before being launched on to the market (92%). This study has identified the main types of supplements used in the Irish equestrian industry along with the reasons for their use. However, it has also highlighted
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Effects of Taurine Supplementation on Neuronal Excitability and Glucose Homeostasis.
El Idrissi, Abdeslem; El Hilali, Fatiha; Rotondo, Salvatore; Sidime, Francoise
2017-01-01
In this study we examined the role of chronic taurine supplementation on plasma glucose homeostasis and brain excitability through activation of the insulin receptor. FVB/NJ male mice were supplemented with taurine in drinking water (0.05% w/v) for 4 weeks and subjected to a glucose tolerance test (7.5 mg/kg BW) after 12 h fasting. We found that taurine-fed mice were slightly hypoglycemic prior to glucose injection and showed significantly reduced plasma glucose at 30 and 60 min post-glucose injection when compared to control mice. Previously, we reported that taurine supplementation induces biochemical changes that target the GABAergic system. Those studies show that taurine-fed mice are hyperexcitable, have reduced GABA A receptors expression and increased GAD and somatostatin expression in the brain. In this study, we found that taurine-fed mice had a significant increase in insulin receptor (IR) immuno-reactivity in the pancreas and all brain regions examined. At the mRNA level, we found that the IR showed differential regional expression. Surprisingly, we found that neurons express the gene for insulin and that taurine had a significant role in regulating insulin gene expression. We propose that increased insulin production and secretion in taurine-fed mice cause an increase activation of the central IR and may be partially responsible for the increased neuronal excitability observed in taurine supplemented mice. Furthermore, the high levels of neuronal insulin expression and its regulation by taurine implicates taurine in the regulation of metabolic homeostasis.
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2013-09-12
...-AD61 Supplemental Standards of Ethical Conduct for Employees of the Department of Housing and Urban... Government Ethics (OGE), amends its Supplemental Standards of Ethical Conduct, which are regulations for HUD officers and employees that supplement the Standards of Ethical Conduct for Employees of the Executive...
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2011-09-20
..., was not subject to review under Section 6(b) of Executive Order 12866, Regulatory Planning and Review... 80% of ``marina-type merchants'' are considered small businesses. Marina-type merchants accepting the SEA Card[reg] will pay a normal fee to the banking institution or processing center, similar to VISA...
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2011-04-19
..., therefore, was not subject to review under Section 6(b) of Executive Order 12866, Regulatory Planning and... their home station. Approximately 80% of ``marina-type merchants'' are considered small businesses. Marina-type merchants accepting the SEA Card[supreg] will pay a normal fee to the banking institution or...
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Regulation of “Banking Group” In Russia in Banking Mergers and Acquisitions in the Modern Conditions
Directory of Open Access Journals (Sweden)
Nikita V. Gurin
2016-01-01
research the author suggests legal developments to the regulations of mergers and acquisitions of banks in Russia.
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77 FR 183 - Federal Acquisition Regulation; Preventing Abuse of Interagency Contracts
2012-01-03
... ensure a level playing field in the acquisition planning process, the FAR should be amended to require a... the ability of the Government to leverage its purchasing power, e.g., will it have a negative effect... Act also provides authority for placement of orders between major organizational units within an...
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17 CFR 200.553 - Draft, final and supplemental impact statements.
2010-04-01
... COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Regulations Pertaining to the Protection of the Environment § 200.553 Draft, final and supplemental impact statements. If the Commission...
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Alber-Morgan, Sheila R.; Joseph, Laurice M.; Kanotz, Brittany; Rouse, Christina A.; Sawyer, Mary R.
2016-01-01
This study examined the effects of implementing word boxes as a supplemental instruction method on the acquisition, maintenance, and generalization of word identification and spelling. Word box intervention consists of using manipulatives to learn phonological decoding skills. The participants were three African-American urban first graders…
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Supplements and other changes to an approved application. Final rule.
2004-04-08
The Food and Drug Administration (FDA) is amending its regulations on supplements and other changes to an approved application to implement the manufacturing changes provision of the Food and Drug Administration Modernization Act of 1997 (the Modernization Act). The final rule requires manufacturers to assess the effects of manufacturing changes on the identity, strength, quality, purity, and potency of a drug or biological product as those factors relate to the safety or effectiveness of the product. The final rule sets forth requirements for changes requiring supplement submission and approval before the distribution of the product made using the change, changes requiring supplement submission at least 30 days prior to the distribution of the product, changes requiring supplement submission at the time of distribution, and changes to be described in an annual report.
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16 CFR 802.70 - Acquisitions subject to order.
2010-01-01
... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Acquisitions subject to order. 802.70 Section 802.70 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND... the Federal Trade Commission or of any Federal court in an action brought by the Federal Trade...
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Tax Implication of Structuring and Financing Mergers and Acquisitions
Directory of Open Access Journals (Sweden)
Cristian Ianca
2008-09-01
Full Text Available The structuring and financing of mergers and acquisitions has substantial tax consequences. The decision to acquire the assets or the shares of the target company should take into consideration, on one hand, the capital gains taxation at the transaction time and, on the other hand, the tax planning opportunities for the future. The tax burden can also be minimized by an optimum selection of the acquisition vehicle. The choice of a financing alternative should take into account the interest deductibility and the specific tax regulations of each jurisdiction concerned.
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Davis, Jon R; DeNardo, Dale F
2009-01-01
In desert species, seasonal peaks in animal activity often correspond with times of higher rainfall. However, the underlying reason for such seasonality can be hard to discern because the rainy season is often associated with shifts in temperature as well as water and food availability. We used a combination of the natural climate pattern of the Sonoran Desert and periodic water supplementation to determine the extent to which water intake influenced both the behavioral ecology and the physiological ecology of a long-lived desert lizard, the Gila monster (Heloderma suspectum) (Cope 1869). Water-supplemented lizards had lower plasma osmolality (i.e., were more hydrated) and maintained urinary bladder water reserves better during seasonal drought than did control lizards. During seasonal drought, water-supplemented lizards were surface active a significantly greater proportion of time than were controls. This increased surface activity can lead to greater food acquisition for supplemental Gila monsters because tail volume (an index of caudal lipid stores) was significantly greater in supplemented lizards compared with controls in one of the two study years.
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Directory of Open Access Journals (Sweden)
Ewa Jablonska
2016-12-01
Full Text Available The aim of the study was to evaluate the effect of selenium supplementation on the expression of genes associated with glucose metabolism in humans, in order to explain the unclear relationship between selenium and the risk of diabetes. For gene expression analysis we used archival samples of cDNA from 76 non-diabetic subjects supplemented with selenium in the previous study. The supplementation period was six weeks and the daily dose of selenium was 200 µg (as selenium yeast. Blood for mRNA isolation was collected at four time points: before supplementation, after two and four weeks of supplementation, and after four weeks of washout. The analysis included 15 genes encoding selected proteins involved in insulin signaling and glucose metabolism. In addition, HbA1c and fasting plasma glucose were measured at three and four time points, respectively. Selenium supplementation was associated with a significantly decreased level of HbA1c but not fasting plasma glucose (FPG and significant down-regulation of seven genes: INSR, ADIPOR1, LDHA, PDHA, PDHB, MYC, and HIF1AN. These results suggest that selenium may affect glycemic control at different levels of regulation, linked to insulin signaling, glycolysis, and pyruvate metabolism. Further research is needed to investigate mechanisms of such transcriptional regulation and its potential implication in direct metabolic effects.
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2012-11-27
... business confidential information provided. FOR FURTHER INFORMATION CONTACT: Mr. Michael O. Jackson, Procurement Analyst, Governmentwide Acquisition Policy, at 202-208-4949 or email michaelo.jackson@gsa.gov...
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Performance enhancement with supplements: incongruence between rationale and practice
Directory of Open Access Journals (Sweden)
Mazanov Jason
2007-11-01
Full Text Available Abstract Background Athletes are expected to consider multiple factors when making informed decision about nutritional supplement use. Besides rules, regulations and potential health hazards, the efficacy of different nutritional supplements in performance enhancement is a key issue. The aim of this paper was to find evidence for informed decision making by investigating the relationship between specific performance-related reasons for supplement use and the reported use of nutritional supplements. Methods The 'UK Sport 2005 Drug Free Survey' data (n = 874 were re-analysed using association [χ2] and 'strength of association' tests [ϕ] to show the proportion of informed choices and to unveil incongruencies between self-reported supplement use and the underlying motives. Results Participants (n = 520 reported supplement use in the pattern of: vitamin C (70.4%, creatine (36.1%, whey protein (30.6%, iron (29.8%, caffeine (23.8%, and ginseng (8.3% for the following reasons: strength maintenance (38.1%, doctors' advice (24.2%, enhancing endurance (20.0%, ability to train longer (13.3%, and provided by the governing body (3.8%. Of thirty possible associations between the above supplements and reasons, 11 were predictable from literature precedents and only 8 were evidenced and these were not strong (ϕ 2 = 49.14, p 2 = 97.08, p 2 = 97.82, p Conclusion This study provided a platform for assessing congruence between athletes' reasons for supplement use and their actual use. These results suggest that a lack of understanding exists in supplement use. There is an urgent need to provide accurate information which will help athletes make informed choices about the use of supplements.
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77 FR 12754 - Contractor Legal Management Requirements; Acquisition Regulations
2012-03-02
... DEPARTMENT OF ENERGY 10 CFR Part 719 48 Parts 931, 952 and 970 RIN 1990-AA37 Contractor Legal... rulemaking (NOPR) to revise existing regulations covering contractor legal management requirements and make... relating to the DOE notice of proposed rulemaking to revise existing regulations covering contractor legal...
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78 FR 2229 - Health and Human Services Acquisition Regulation
2013-01-10
... information (regardless of the form or method of the recording) of a scientific or technical nature (including... (HHSAR)--to add two clauses, ``Patent Rights-- Exceptional Circumstances'' and ``Rights in Data....227-11 and 352.227-14'' by any of the following methods: Regulations.gov : http://www.regulations.gov...
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Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation
Directory of Open Access Journals (Sweden)
Cunningham Phil
2010-10-01
Full Text Available Abstract Background Dietary zinc supplementation may help to promote growth, boost the immune system, protect against diabetes, and aid recovery from diarrhoea. We exploited the zebrafish (Danio rerio gill as a unique vertebrate ion transporting epithelium model to study the time-dependent regulatory networks of gene-expression leading to homeostatic control during zinc supplementation. This organ forms a conduit for zinc uptake whilst exhibiting conservation of zinc trafficking components. Results Fish were maintained with either zinc supplemented water (4.0 μM and diet (2023 mg zinc kg-1 or water and diet containing Zn2+ at 0.25 μM and 233 mg zinc kg-1, respectively. Gill tissues were harvested at five time points (8 hours to 14 days and transcriptome changes analysed in quintuplicate using a 16 K microarray with results anchored to gill Zn2+ influx and whole body nutrient composition (protein, carbohydrate, lipid, elements. The number of regulated genes increased up to day 7 but declined as the fish acclimated. In total 525 genes were regulated (having a fold-change more than 1.8 fold change and an adjusted P-value less than 0.1 which is controlling a 10% False discovery rate, FDR by zinc supplementation, but little overlap was observed between genes regulated at successive time-points. Many genes displayed cyclic expression, typical for homeostatic control mechanisms. Annotation enrichment analysis revealed strong overrepresentation of "transcription factors", with specific association evident with "steroid hormone receptors". A suite of genes linked to "development" were also statistically overrepresented. More specifically, early regulation of genes was linked to a few key transcription factors (e.g. Mtf1, Jun, Stat1, Ppara, Gata3 and was followed by hedgehog and bone morphogenic protein signalling. Conclusions The results suggest that zinc supplementation reactivated developmental pathways in the gill and stimulated stem cell
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78 FR 5449 - Federal Acquisition Regulation; Submission of OMB Review; Advance Payments
2013-01-25
...; Submission of OMB Review; Advance Payments AGENCIES: Department of Defense (DOD), General Services... requirement concerning advance payments. A notice was published in the Federal Register at 77 FR 43083, on... collection of information is necessary for the proper performance of functions of the Federal Acquisition...
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12 CFR 225.21 - Prohibited nonbanking activities and acquisitions; exempt bank holding companies.
2010-01-01
... CONTROL (REGULATION Y) Regulations Nonbanking Activities and Acquisitions by Bank Holding Companies § 225... company or a subsidiary may not engage in, or acquire or control, directly or indirectly, voting... Internal Revenue Code (26 U.S.C. 501(c)). (3) Companies granted hardship exemption. Any bank holding...
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... Staying Safe Videos for Educators Search English Español Sports Supplements KidsHealth / For Teens / Sports Supplements What's in ... really work? And are they safe? What Are Sports Supplements? Sports supplements (also called ergogenic aids ) are ...
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A nonrandomized trial of vitamin D supplementation for Barrett's esophagus.
Directory of Open Access Journals (Sweden)
Linda C Cummings
Full Text Available Vitamin D deficiency may increase esophageal cancer risk. Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH in other cancers. This nonrandomized interventional study assessed effects of vitamin D supplementation in Barrett's esophagus (BE. We hypothesized that vitamin D supplementation may have beneficial effects on gene expression including 15-PGDH in BE.BE subjects with low grade or no dysplasia received vitamin D3 (cholecalciferol 50,000 international units weekly plus a proton pump inhibitor for 12 weeks. Esophageal biopsies from normal plus metaplastic BE epithelium and blood samples were obtained before and after vitamin D supplementation. Serum 25-hydroxyvitamin D was measured to characterize vitamin D status. Esophageal gene expression was assessed using microarrays.18 study subjects were evaluated. The baseline mean serum 25-hydroxyvitamin D level was 27 ng/mL (normal ≥30 ng/mL. After vitamin D supplementation, 25-hydroxyvitamin D levels rose significantly (median increase of 31.6 ng/mL, p<0.001. There were no significant changes in gene expression from esophageal squamous or Barrett's epithelium including 15-PGDH after supplementation.BE subjects were vitamin D insufficient. Despite improved vitamin D status with supplementation, no significant alterations in gene expression profiles were noted. If vitamin D supplementation benefits BE, a longer duration or higher dose of supplementation may be needed.
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77 FR 8843 - Acquisition of Items for Which Federal Prison Industries Has a Significant Market Share
2012-02-15
... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System Acquisition of Items for Which Federal Prison Industries Has a Significant Market Share AGENCY: Department of Defense (DoD). ACTION... product categories for which the Federal Prison Industries' share of the DoD market is greater than five...
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2010-03-01
... Council, Crystal Square 4, Suite 200A, 241 18th Street, Arlington, VA 22202-3402. Comments received.... (ix) In the case of a contract with a cancellation ceiling in excess of $100 million, if the budget... cancellation ceiling established in the contract-- (A) The head of the agency shall, as part of this...
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2010-03-03
... exfiltration, minimally including the following: (i) Current and regularly updated malware protection services... data exfiltration, as follows: (A) Current and regularly updated malware protection services, e.g... ingress, egress, and exfiltration through technologies such as firewalls and router policies, intrusion...
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2013-02-28
..., either formal or informal, that encourage the pursuit of education and experience in the science..., programs or initiatives, either formal or informal, which encourage the pursuit of education and experience... Title I schools in order to enhance STEM education and programs; Making personnel available to advise...
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2012-06-15
.... The essence of the definition cannot be changed substantially in the DFARS from that in the... recommended that the final rule define the contractor's obligation to cooperate, as in the mandatory... define the scope and limitations of the contractor's obligation to cooperate with Government...
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2013-04-01
... subcontractors and suppliers; and (3) foster the establishment of long-term business relationships between... technology. The Office of Management and Budget (OMB) has approved this information collection for use...
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2012-05-24
..., Government Property, DFARS section 211.274, Reporting of Government-Furnished Equipment in the DoD Item... surplus Government property. Under paragraph (b), a contractor may be directed by the plant clearance... plant clearance officer to purchase or retain Government property at less than cost if the plant...
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2011-11-23
.... 13563 emphasizes the importance of quantifying both costs and benefits, of reducing costs, of..., was not subject to review under section 6(b) of E.O. 12866, Regulatory Planning and Review, dated... require the approval of the Office of Management and Budget under the Paperwork Reduction Act (44 U.S.C...
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2012-12-13
.../index.htm . Paper copies are available from Ms. Meredith Murphy, OUSD (AT&L) DPAP (DARS), IMD 3C132... material management and accounting systems conform to established DoD standards. c. The information... to establish, maintain, and disclose material management and accounting systems. c. DFARS 252.247...
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2013-11-15
... or other forms of information technology. The Office of Management and Budget (OMB) has approved this... Services. The provision at DFARS 252.237- 7024 requires offerors to submit with its offer a written plan describing how it will continue to perform essential contractor services during periods of crisis. The...
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2013-10-24
... 252.225-7010, Commercial Derivative Military Article-- Specialty Metals Compliance Certificate, as... commercial derivative military articles to the Government. DFARS 252.225-7013, Duty-Free Entry, as prescribed... of origin. DFARS 252.225-7020, Trade Agreements Certificate, as prescribed in 225.1101(5), requires...
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2013-11-18
... not align with the protection requirements in the NISPOM. 3. Policy Regarding Outsourcing, Cloud... contractors and on international information sharing agreements. Response: The technical information covered... be applied to all systems. Comments also indicated that DFARS should not apply to International...
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2010-11-24
... Act DoD does not expect this proposed rule to have a significant economic impact on a substantial...-7031, Secondary Arab Boycott of Israel. This provision applies to all solicitations unless an exception...
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2011-09-20
... Boycott of Israel. (ix) 252.225-7035, Buy American Act--Free Trade Agreements--Balance of Payments Program... Arab Boycott of Israel. ----(vi) 252.225-7035, Buy American Act--Free Trade Agreements-- Balance of...
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2011-08-19
... Outside the United States.'' DFARS 225.302-3, Definitions, provides the definition of ``private security... this total, 361, or 20 percent, were awarded to small businesses. Firms performing private security... private security functions in response to a perceived immediate threat; (2) Ensure that all employees of...
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41 CFR 102-73.15 - What real estate acquisition and related services may Federal agencies provide?
2010-07-01
... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What real estate... REGULATION REAL PROPERTY 73-REAL ESTATE ACQUISITION General Provisions § 102-73.15 What real estate... provide real estate acquisition and related services, including leasing (with or without purchase options...
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Directory of Open Access Journals (Sweden)
Mehri Jamilian
2018-01-01
Full Text Available Abstract Background: Selenium supplement has multiple important effects, including anti-inflammatory effect. The aim of this study was to assess the effects of selenium supplement on gene expression of inflammatory cytokines and vascular endothelial growth factor in gestational diabetes. Materials and Methods: This randomized double blind placebo control trial was performed on 40 patients suffering from GDM aged 18–40 years old. Participants were randomly divided into interventional group receiving 200mg/day selenium supplements (n=20 and control group receiving placebo (n=20 for 6 weeks. Primary outcome was gene expression of inflammatory cytokines and VEGF which were assessed in lymphocyte of GDM patients by RT-PCR method. Results: After 6 weeks intervention, in comparison with the control group, interventional group showed down regulation of gene expression of tumor necrosis factor alpha (TNF–α (p=0.02 and transforming growth factor beta (TGF–β (p=0.01 and up-regulation of gene expression of vascular endothelial (VEGF (p = 0.03 in lymphocytes of GDM. There was not any significant change following intervention with selenium regarding gene expression of interleukin IL-1 β and IL-8 in lymphocytes of GDM patients. Conclusion: 6 weeks supplementation with selenium in patients with GDM can cause down regulated gene expression of TNF-α and TGF–β, and up regulated gene expression of VEGF. Selenium supplement had not any effect on gene expression of IL-1 β and IL-8.
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DEFF Research Database (Denmark)
Meglio, Olimpia; King, David R.; Risberg, Annette
2017-01-01
The advantage of speed is often invoked by academics and practitioners as an essential condition during post-acquisition integration, frequently without consideration of the impact earlier decisions have on acquisition speed. In this article, we examine the role speed plays in acquisitions across...... the acquisition process using research organized around characteristics that display complexity with respect to acquisition speed. We incorporate existing research with a process perspective of acquisitions in order to present trade-offs, and consider the influence of both stakeholders and the pre......-deal-completion context on acquisition speed, as well as the organization’s capabilities to facilitating that speed. Observed trade-offs suggest both that acquisition speed often requires longer planning time before an acquisition and that associated decisions require managerial judgement. A framework for improving...
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48 CFR 1252.217-80 - Department of Labor Safety and Health Regulations for Ship Repairing.
2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Department of Labor Safety and Health Regulations for Ship Repairing. 1252.217-80 Section 1252.217-80 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 1252.217-80...
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Information on nutritional supplement labels: time for legislation ...
African Journals Online (AJOL)
To assist this process, it is important to have specific knowledge and understanding of the claims made on labels of nutritional supplement products used for general, and more specifically, for sports consumers. The industry is not regulated, and therefore the claims that are made may not always be accurate. Method: The ...
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外资并购系列法规陆续出台%Series of rules on foreign acquisitions to be promulgated
Institute of Scientific and Technical Information of China (English)
无
2003-01-01
Following the promulgation of the Administrative Procedures on Acquisition of Listed Companies,the China Securities Regulatory Commission(CSRC)will promulgate one after another supporting documents related to acquisition of listed companies and a series of laws and regulations aimde to standerdize mergers and acquisition,
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Determinants of dietary supplement use--healthy individuals use dietary supplements.
Kofoed, Christina L F; Christensen, Jane; Dragsted, Lars O; Tjønneland, Anne; Roswall, Nina
2015-06-28
The prevalence of dietary supplement use varies largely among populations, and previous studies have indicated that it is high in the Danish population compared with other European countries. The diversity in supplement use across countries indicates that cultural and environmental factors could influence the use of dietary supplements. Only few studies investigating the use of dietary supplements have been conducted in the Danish population. The present cross-sectional study is based on 54,948 Danes, aged 50-64 years, who completed self-administrated questionnaires on diet, dietary supplements and lifestyle between 1993 and 1997. A health index including smoking, physical activity, alcohol and diet, and a metabolic risk index including waist circumference, urinary glucose and measured hypertension were constructed. Logistic regression was used to investigate these determinants in relation to the intake of dietary supplements. We found that 71 % of the participants were dietary supplement users; female sex, older age groups and higher educated participants were more likely to be users of any dietary supplements. One additional point in the health index was associated with 19, 16 and 9 % higher likelihood of being user of any, more common and less common supplements, respectively. In the metabolic risk index, one additional point was associated with 17 and 16 % lower likelihood of being user of any supplement and more common supplements, respectively. No significant association was found for less common supplement use. In conclusion, those with the healthiest lifestyle were more likely to use dietary supplements. Thus, lifestyle and dietary composition should be considered as confounders on supplement use and health outcomes.
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Vasoprotection by Dietary Supplements and Exercise: Role of TNFα Signaling
Directory of Open Access Journals (Sweden)
Hanrui Zhang
2012-01-01
Full Text Available Vascular dysfunction contributes to the pathogenesis of various cardiovascular diseases. Dietary supplements, including fish oil, dietary fibers, and various natural products, and exercise training exert vasoprotective effects. However, the mechanisms underlying the vasoprotective benefits of dietary supplements and physical activity demand extensive investigation. Accumulating evidence suggests that inflammatory cytokine tumor necrosis factor-alpha (TNFα plays a pivotal role in the dysregulation of macrovascular and microvascular function. TNFα induces vascular inflammation, monocyte adhesion to endothelial cells, vascular oxidative stress, apoptosis, and atherogenic response and participates in the regulation of thrombosis and coagulation through multiple signaling pathways involving NFκB, Sp1, activator protein 1, JNK, p38, STAT3, and so forth. Dietary supplements and exercise training decrease TNFα production and ameliorate TNFα-mediated pathological changes in vasculature. Thus, the inhibitory effects of dietary supplements and physical exercise on TNFα production and TNFα signaling may contribute to their vasoprotective properties.
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2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Short selection process for procurements not to exceed the simplified acquisition threshold. 736.602-5 Section 736.602-5... CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 736.602-5 Short...
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2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Short selection processes... ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 636.602-5 Short selection processes for contracts not to exceed the simplified acquisition threshold. The short selection process described in FAR 36...
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2010-10-01
... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Prohibition on acquisition of United States Munitions List items from Communist Chinese military companies. 225.770 Section 225... of United States Munitions List items from Communist Chinese military companies. This section...
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Directory of Open Access Journals (Sweden)
Cornelius Killian
2011-05-01
Full Text Available This paper analyses the statement made by the South African Appeal Court Judge Holmes in the Phame v Paizes (1973 case and, using economic and unique South African legal principles, it examines the true legal nature of a contract to regulate company acquisitions.1 Two solutions are offered for financial managers in South Africa: (1 the contract to regulate company acquisitions is a forward contract and (2 the difficulty in identifying latent defects should not be grounds for reducing the price paid for a company or enterprise in the South African legal system.
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Acquisition (Purchasing of ERP Systems from Organizational Buying Behavior Perspective
Directory of Open Access Journals (Sweden)
Tariq Bhatti
2014-05-01
Full Text Available Enterprise Resource Planning (ERP systems are becoming a mature infrastructure in many organizations. Organizations purchase these systems to integrate, improve internal business processes, serve their customers better and fulfill their needs. The buying process of these systems is more complicated and it requires a lot more consideration as it can have long term effects and consequences for the organization as well as for its stakeholders. Acquisition (purchasing of ERP systems is a complex behavior for organizations and has a lot to consider, from motives all the way to goals being pursued. Buying organizations consider several components that make up its business entity: like vendors, consumers, competitors, and regulations (Harris, 2013. Importance and relevance should be given to each one of these components as they all play key essential roles in sales organizations and their success. Typical organizations treat the purchasing process as a problem solving situation and rely on consultants or sometimes miss out on systematic buying process and the success factors to be considered vary from technicality, price, risk aversion, reputation, all the way to ethical decisions and legal regulations (Bellizzi, 2009. This research paper describe the current acquisition processes, critical success factors literature and propose integrated ERP systems acquisition model for organizations interested in buying similar systems in future.
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77 FR 57949 - Federal Acquisition Regulation; Positive Law Codification of Title 41
2012-09-18
... establishment and use of electronic commerce in Federal acquisition as required by 41 U.S.C. 2301. 4.502... previously approved under the Office of Management and Budget Control Number 1215-0017, titled: Records to be... executive means the individual appointed pursuant to 41 U.S.C. 1702(c) who is responsible for management...
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CADMIUM AND ZINC CONCENTRATIONS IN THE HAIR AFTER OF ADULTS MAGNESIUM SUPPLEMENTATION
Directory of Open Access Journals (Sweden)
Anna Sałacka
2010-03-01
Full Text Available Background: Cadmium is a biological zinc antagonist and may interfere with metabolic zinc-regulated or zincdependent processes. The aim of this study was to assess the relationship between cadmium and zinc concentrations in the hair of adults after oral supplementation with magnesium. Material and methods: The levels of elements in the hair were determined by the inverse voltammetry. The analysis was performed on the hair of 32 people from the study group and 10 from the control group. Supplementation was performed using Slow-Mag B6. Results: Cadmium concentration in the study group before supplementation ranged from indeterminable levels, to 1,92 µg per gram of dry matter. The range of cadmium concentration after supplementation was between the indeterminable level, and 0,45 µg per gram of dry matter. Based on the statistical analysis, we found that cadmium concentration was significantly lower after magnesium supplementation with a significance level of p*0,02. Zinc level before supplementation was between 11,66 and 250,48 µg per gram of dry matter, and after supplementation between 68,31 and 185,24 µg per gram of dry matter. Conclusion: The results obtained suggest that supplementation with magnesium contributed to the lowering of cadmium concentration in the hair of the people examined.
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2010-10-01
... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 836.602-5 Section 836.602-5 Federal... AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 836.602-5 Short selection process for...
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A Synopsis of Acquisition Related Topics.
1983-03-01
practices, ov.rnmen-. regulations and the economic environment . As with any other reference manual, this thesis will need to be up.la:ed and supplemented...construction cor:tracts Ccpeland "Anti- 18 USC 874 Prohibits kickbacks Kickback" Act 40 USC 276c from employees on public works Maybank Azendment Annual...ttismsnt by enccuraging challenge c. cor.trac-’rs’ dAD reca.ion methods: If the method selaec.ed is also use=d for external finarcial reporting a-id :Ls
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Effects of dietary supplementation of Chinese herb medicine mixture ...
African Journals Online (AJOL)
South African Journal of Animal Science ... These results indicated that the dietary supplementation of the CHM mixture exerted some positive regulating effects on the nervous system, the endocrine system and the immune system of goats, thus improving the functions of immunity and antioxidation, as well as the digestion ...
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American Society for Testing and Materials. Philadelphia
2010-01-01
1.1 This guide discusses test procedures that can be used in conjunction with, but not as alternatives to, those required by Practices E185 and E2215 for the surveillance of nuclear reactor vessels. The supplemental mechanical property tests outlined permit the acquisition of additional information on radiation-induced changes in fracture toughness, notch ductility, and yield strength properties of the reactor vessel steels. 1.2 This guide provides recommendations for the preparation of test specimens for irradiation, and identifies special precautions and requirements for reactor surveillance operations and postirradiation test planning. Guidance on data reduction and computational procedures is also given. Reference is made to other ASTM test methods for the physical conduct of specimen tests and for raw data acquisition.
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Schoch, Ryan D; Willoughby, Darryn; Greenwood, Mike
2006-01-01
Abstract Creatine monohydrate has become one of the most popular ergogenic sport supplements used today. It is a nonessential dietary compound that is both endogenously synthesized and naturally ingested through diet. Creatine ingested through supplementation has been observed to be absorbed into the muscle exclusively by means of a creatine transporter, CreaT1. The major rationale of creatine supplementation is to maximize the increase within the intracellular pool of total creatine (creatin...
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Chen, Zhe; Zhang, Lingli; Zeng, Linan; Yang, Xiaoyan; Jiang, Lucan; Gui, Ge; Zhang, Zuojie
2017-01-01
Background: Neonatal jaundice is a relatively prevalent disease and affects approximately 2.4–15% newborns. Probiotics supplementation therapy could assist to improve the recovery of neonatal jaundice, through enhancing immunity mainly by regulating bacterial colonies. However, there is limited evidence regarding the effect of probiotics on bilirubin level in neonates. Therefore, this study aims at systematically evaluating the efficacy and safety of probiotics supplement therapy for patholog...
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78 FR 45198 - Federal Acquisition Regulation; Submission for OMB Review; Anti-Kickback Procedures
2013-07-26
... INFORMATION CONTACT: Ms. Cecelia L. Davis, Procurement Analyst, Office of Governmentwide Acquisition Policy..., Contractor Business Ethics Compliance Program and Disclosure Requirements. Response: It is important to... business. In the normal course of business, a company that is concerned about ethical behavior will take...
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Alexandаr Marinkov
2016-01-01
Sport supplementation is essential for athletes performance and achievements. The well balanced and structured supplementation is a challenge for sport medicine because must be done a balance between potential benefits and potential risks (anti-doping rule violations and others). In this review are structured the most used categories sport supplementations. Nutritional supplements used in sport could be divided in some main categories like: amino acids, vitamins, proteins and antioxidants. Fo...
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2010-10-01
... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Short selection process for contracts not to exceed the simplified acquisition threshold. 436.602-5 Section 436.602-5 Federal... ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Service 436.602-5 Short selection process for contracts not...
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McCary, Christine A.; Abdala-Valencia, Hiam; Berdnikovs, Sergejs; Cook-Mills, Joan M.
2011-01-01
We have reported that supplemental doses of the α- and γ-tocopherol isoforms of vitamin E decrease and increase, respectively, allergic lung inflammation. We have now assessed whether these effects of tocopherols are reversible. For these studies, mice were treated with antigen and supplemental tocopherols in a first phase of treatment followed by a 4 week clearance phase and then the mice received a second phase of antigen and tocopherol treatments. The pro-inflammatory effects of supplement...
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2013-03-22
.... FOR FURTHER INFORMATION CONTACT: Mr. Michael O. Jackson, Procurement Analyst, Office of Governmentwide Acquisition Policy GSA, at (202) 208- 4949 or via email at michaelo.jackson@gsa.gov . SUPPLEMENTARY...
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Role of the pituitary-adrenal hormones in the acquisition of schedule-induced polydipsia.
Levine, R; Levine, S
1989-06-01
Adrenalectomized female rats failed to develop schedule-induced polydipsia (SIP). Dexamethasone (DEX) injections failed to reinstate SIP in adrenalectomized rats. They did not prevent intact rats from acquiring SIP but interfered with subsequent expression of this behavior. In contrast, corticosterone, the rats' normally occurring glucocorticoid, fully restored the acquisition and subsequent expression of SIP in adrenalectomized rats. This strongly suggests that corticosterone plays an essential role in the normal acquisition and development of this behavior. Data are interpreted in the context of current information concerning adrenal hormone receptors. It is hypothesized SIP acquisition is at least partly regulated by the Type I (mineralocorticoid) receptor.
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77 FR 51867 - Cotton Board Rules and Regulations: Adjusting Supplemental Assessment on Imports
2012-08-28
... Advertising, Agricultural research, Cotton, Marketing agreements, Reporting and recordkeeping requirements... supplemental assessments collected for use by the Cotton Research and Promotion Program. An amendment is..., Chief, Research and Promotion Staff, Cotton and Tobacco Programs, AMS, USDA, 100 Riverside Parkway...
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Abebe, Worku
2003-01-01
Herbal medication in the United States is a popular form of therapy. This paper provides an overview of the utilization of herbal supplements with particular emphasis on possible interactions with oral health drugs and oral manifestations. Herbal supplements are regulated by the Dietary Supplement Health and Education Act (DSHEA), which limits their regulation by the U.S Food and Drug Administration (FDA). A number of studies indicate that there is a progressive increase in the utilization of herbal supplements. The majority of consumers of these products are white, middle-aged women who have some college education. Many of the consumers use pharmaceutical drugs concurrently, but most do not inform their health-care providers about their use of herbal supplements. Various herbal supplements have been reported or are suspected to interact with certain oral health drugs, the most important one being 1) bromelain, cayenne, chamomile, feverfew, dong quai, eleuthro/Seberian ginseng, garlic, ginkgo, ginger, ginseng and licorice interacting with aspirin; 2) aloe latex, ephedra, ginseng, rhubarb, cascara sagrada, licorice, and senna interacting with corticosteriods; 3) kava, St. John's wort, chamomile, and valerian interacting with central nervous system (CNS) depressant drugs; and 4) herbs acting on the gastrointestinal system, altering the absorption of several orally administered drugs. Further, the use of some herbal supplements has been reported to be associated with oral manifestations, including aphthous ulcers, lip and tongue irritation, and swelling with feverfew; gingival bleeding with feverfew and ginkgo; tongue numbness with echinacea; xerostomia with St. John's wort; oral and lingual dyskinesia with kava; and salivation with yohimbe. These potential effects of herbal supplements in conjunction with factors related to regulation restrictions suggest that the use of these products may be associated with various adverse reactions that can affect oral health and
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International Nuclear Information System (INIS)
Sader, Kasim; Schaffer, Bernhard; Vaughan, Gareth; Brydson, Rik; Brown, Andy; Bleloch, Andrew
2010-01-01
We have developed a novel acquisition methodology for the recording of electron energy loss spectra (EELS) using a scanning transmission electron microscope (STEM): 'Smart Acquisition'. Smart Acquisition allows the independent control of probe scanning procedures and the simultaneous acquisition of analytical signals such as EELS. The original motivation for this work arose from the need to control the electron dose experienced by beam-sensitive specimens whilst maintaining a sufficiently high signal-to-noise ratio in the EEL signal for the extraction of useful analytical information (such as energy loss near edge spectral features) from relatively undamaged areas. We have developed a flexible acquisition framework which separates beam position data input, beam positioning, and EELS acquisition. In this paper we demonstrate the effectiveness of this technique on beam-sensitive thin films of amorphous aluminium trifluoride. Smart Acquisition has been used to expose lines to the electron beam, followed by analysis of the structures created by line-integrating EELS acquisitions, and the results are compared to those derived from a standard EELS linescan. High angle annular dark-field images show clear reductions in damage for the Smart Acquisition areas compared to the conventional linescan, and the Smart Acquisition low loss EEL spectra are more representative of the undamaged material than those derived using a conventional linescan. Atomically resolved EELS of all four elements of CaNdTiO show the high resolution capabilities of Smart Acquisition.
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Energy Technology Data Exchange (ETDEWEB)
Sader, Kasim, E-mail: k.sader@leeds.ac.uk [SuperSTEM, J block, Daresbury Laboratory, Warrington, Cheshire, WA4 4AD (United Kingdom); Institute for Materials Research, University of Leeds, LS2 9JT (United Kingdom); Schaffer, Bernhard [SuperSTEM, J block, Daresbury Laboratory, Warrington, Cheshire, WA4 4AD (United Kingdom); Department of Physics and Astronomy, University of Glasgow (United Kingdom); Vaughan, Gareth [Institute for Materials Research, University of Leeds, LS2 9JT (United Kingdom); Brydson, Rik [SuperSTEM, J block, Daresbury Laboratory, Warrington, Cheshire, WA4 4AD (United Kingdom); Institute for Materials Research, University of Leeds, LS2 9JT (United Kingdom); Brown, Andy [Institute for Materials Research, University of Leeds, LS2 9JT (United Kingdom); Bleloch, Andrew [SuperSTEM, J block, Daresbury Laboratory, Warrington, Cheshire, WA4 4AD (United Kingdom); Department of Engineering, University of Liverpool, Liverpool (United Kingdom)
2010-07-15
We have developed a novel acquisition methodology for the recording of electron energy loss spectra (EELS) using a scanning transmission electron microscope (STEM): 'Smart Acquisition'. Smart Acquisition allows the independent control of probe scanning procedures and the simultaneous acquisition of analytical signals such as EELS. The original motivation for this work arose from the need to control the electron dose experienced by beam-sensitive specimens whilst maintaining a sufficiently high signal-to-noise ratio in the EEL signal for the extraction of useful analytical information (such as energy loss near edge spectral features) from relatively undamaged areas. We have developed a flexible acquisition framework which separates beam position data input, beam positioning, and EELS acquisition. In this paper we demonstrate the effectiveness of this technique on beam-sensitive thin films of amorphous aluminium trifluoride. Smart Acquisition has been used to expose lines to the electron beam, followed by analysis of the structures created by line-integrating EELS acquisitions, and the results are compared to those derived from a standard EELS linescan. High angle annular dark-field images show clear reductions in damage for the Smart Acquisition areas compared to the conventional linescan, and the Smart Acquisition low loss EEL spectra are more representative of the undamaged material than those derived using a conventional linescan. Atomically resolved EELS of all four elements of CaNdTiO show the high resolution capabilities of Smart Acquisition.
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2011-11-02
... Contractor Employees Performing Acquisition Functions AGENCIES: Department of Defense (DoD), General Services... personal conflicts of interest by employees of Government contractors as required by statute. DATES... clause for future orders. In the event that a contractor refuses to accept such a modification, the...
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77 FR 59790 - General Services Administration Acquisition Regulation (GSAR); Rewrite of Part 504...
2012-10-01
... and Forms. This final rule is part of the General Services Administration Acquisition Manual (GSAM... the prescription for inclusion of the clause at 552.204-9, Personal Identity Verification Requirements... the ``National Industrial Security Program Operating Manual (NISPOM)'', and link to the web address...
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77 FR 67366 - Federal Acquisition Regulation; Information Collection; Travel Costs
2012-11-09
...; Information Collection; Travel Costs AGENCY: Department of Defense (DOD), General Services Administration (GSA... requirement concerning Travel Costs. Public comments are particularly invited on: Whether this collection of...- 0088, Travel Costs by any of the following methods: Regulations.gov : http://www.regulations.gov...
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Effect of raceme-localized supplemental light on soybean reproductive abscission
International Nuclear Information System (INIS)
Myers, R.L.; Brun, W.A.; Brenner, M.L.
1987-01-01
The percentage of soybean [Glycine max (L.) Merr.] reproductive structures that abscise is a potentially important yield factor. To better understand the involvement of light in the abscission of reproductive structures, a series of in vitro raceme-culture and growth-chamber experiments were conducted. In the in vitro raceme-culture experiments, racemes with four to six flowers at or past anthesis were excised from the soybean plant (genotype IX93-100), embedded in a complete nutrient, solid agar medium, and subjected to various light treatments. A series of three experiments indicated that the racemes contain a photoreceptor, possibly phytochrome, capable of regulating sucrose accumulation. In each of the growth chamber studies, supplemental light was supplied directly to individual soybean flowers via fiber optic light guides. The light source increased the photon flux to the flowers by 10-fold. The first growth chamber experiment showed that flowers receiving supplemental light were more intense sinks for 14 C-sucrose than were controls (intensity value of 1.0 vs 0.4 x 10 -7 , intensity = [dps of flower/dps of raceme]/[kg dry wt of flower]). In a second study, 42% of flowers treated with supplemental light set pods, while only 26% of control flowers set pods. A third experiment showed that red supplemental light produced 55% fruit set, compared to 41% set for far-red light, and 35% for controls. These experiments indicate that both photoassimilate accumulation and abscission in young soybean reproductive structures may be regulated by light quality
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McCary, Christine A.; Abdala-Valencia, Hiam; Berdnikovs, Sergejs; Cook-Mills, Joan M.
2011-01-01
We have reported that supplemental doses of the α- and γ-tocopherol isoforms of vitamin E decrease and increase, respectively, allergic lung inflammation. We have now assessed whether these effects of tocopherols are reversible. For these studies, mice were treated with antigen and supplemental tocopherols in a first phase of treatment followed by a 4 week clearance phase and then the mice received a second phase of antigen and tocopherol treatments. The pro-inflammatory effects of supplemental levels of γ-tocopherol in phase 1 were only partially reversed by supplemental α-tocopherol in phase 2 but were completely reversed by raising α-tocopherol levels 10-fold in phase 2. When γ-tocopherol levels were increased 10-fold (highly-elevated tocopherol) so that the lung tissue γ-tocopherol levels were equal to the lung tissue levels of supplemental α-tocopherol, γ-tocopherol reduced leukocyte numbers in the lung lavage fluid. In contrast to the lung lavage fluid, highly-elevated levels of γ-tocopherol increased inflammation in the lung tissue. These regulatory effects of highly-elevated tocopherols on tissue inflammation and lung lavage fluid were reversible in a second phase of antigen challenge without tocopherols. In summary, the pro-inflammatory effects of supplemental γ-tocopherol on lung inflammation were partially reversed by supplemental levels of α-tocopherol but were completely reversed by highly-elevated-levels of α-tocopherol. Also, highly-elevated levels of γ-tocopherol were inhibitory and reversible in lung lavage but, importantly, were pro-inflammatory in lung tissue sections. These results have implications for future studies with tocopherols and provide a new context in which to review vitamin E studies in the literature. PMID:21317387
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Omega-3 fatty acid supplementation and cardiovascular disease
Jump, Donald B.; Depner, Christopher M.; Tripathy, Sasmita
2012-01-01
Epidemiological studies on Greenland Inuits in the 1970s and subsequent human studies have established an inverse relationship between the ingestion of omega-3 fatty acids [C20–22 ω 3 polyunsaturated fatty acids (PUFA)], blood levels of C20–22 ω 3 PUFA, and mortality associated with cardiovascular disease (CVD). C20–22 ω 3 PUFA have pleiotropic effects on cell function and regulate multiple pathways controlling blood lipids, inflammatory factors, and cellular events in cardiomyocytes and vascular endothelial cells. The hypolipemic, anti-inflammatory, anti-arrhythmic properties of these fatty acids confer cardioprotection. Accordingly, national heart associations and government agencies have recommended increased consumption of fatty fish or ω 3 PUFA supplements to prevent CVD. In addition to fatty fish, sources of ω 3 PUFA are available from plants, algae, and yeast. A key question examined in this review is whether nonfish sources of ω 3 PUFA are as effective as fatty fish-derived C20–22 ω 3 PUFA at managing risk factors linked to CVD. We focused on ω 3 PUFA metabolism and the capacity of ω 3 PUFA supplements to regulate key cellular events linked to CVD. The outcome of our analysis reveals that nonfish sources of ω 3 PUFA vary in their capacity to regulate blood levels of C20–22 ω 3 PUFA and CVD risk factors. PMID:22904344
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Spillover of Corporate Governance Standards in Cross-Border Mergers and Acquisitions
Martynova, M.; Renneboog, L.D.R.
2008-01-01
In cross-border acquisitions, the differences between the bidder and target corporate governance have an important impact on the takeover returns. Our country-level corporate governance indices capture the changes in the quality of the national corporate governance regulations over the past 15
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Language Acquisition without an Acquisition Device
O'Grady, William
2012-01-01
Most explanatory work on first and second language learning assumes the primacy of the acquisition phenomenon itself, and a good deal of work has been devoted to the search for an "acquisition device" that is specific to humans, and perhaps even to language. I will consider the possibility that this strategy is misguided and that language…
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2012-11-05
...; whether our estimate of the public burden of this collection of information is accurate, and based on... provided. FOR FURTHER INFORMATION CONTACT: Mr. Curtis E. Glover, Sr., Procurement Analyst, Contract Policy Division, GSA, (202) 501-1448 or email at [email protected] . A. Purpose Per Federal Acquisition...
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Post-Acquisition IT Integration
DEFF Research Database (Denmark)
Henningsson, Stefan; Yetton, Philip
2013-01-01
The extant research on post-acquisition IT integration analyzes how acquirers realize IT-based value in individual acquisitions. However, serial acquirers make 60% of acquisitions. These acquisitions are not isolated events, but are components in growth-by-acquisition programs. To explain how...... serial acquirers realize IT-based value, we develop three propositions on the sequential effects on post-acquisition IT integration in acquisition programs. Their combined explanation is that serial acquirers must have a growth-by-acquisition strategy that includes the capability to improve...... IT integration capabilities, to sustain high alignment across acquisitions and to maintain a scalable IT infrastructure with a flat or decreasing cost structure. We begin the process of validating the three propositions by investigating a longitudinal case study of a growth-by-acquisition program....
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76 FR 54078 - Cotton Board Rules and Regulations: Adjusting Supplemental Assessment on Imports
2011-08-31
... requirements previously approved. List of Subjects in 7 CFR Part 1205 Advertising, Agricultural research... purpose of calculating supplemental assessments collected for use by the Cotton Research and Promotion...: Effective Date: September 30, 2011. FOR FURTHER INFORMATION CONTACT: Shethir M. Riva, Chief, Research and...
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A review of dietary supplement-induced renal dysfunction.
Gabardi, Steven; Munz, Kristin; Ulbricht, Catherine
2007-07-01
Complementary and alternative medicine (CAM) is a multibillion-dollar industry. Almost half of the American population uses some form of CAM, with many using them in addition to prescription medications. Most patients fail to inform their health care providers of their CAM use, and physicians rarely inquire. Annually, thousands of dietary supplement-induced adverse events are reported to Poison Control Centers nationwide. CAM manufacturers are not responsible for proving safety and efficacy, because the Food and Drug Administration does not regulate them. However, concern exists surrounding the safety of CAM. A literature search using MEDLINE and EMBASE was undertaken to explore the impact of CAM on renal function. English-language studies and case reports were selected for inclusion but were limited to those that consisted of human subjects, both adult and pediatric. This review provides details on dietary supplements that have been associated with renal dysfunction and focuses on 17 dietary supplements that have been associated with direct renal injury, CAM-induced immune-mediated nephrotoxicity, nephrolithiasis, rhabdomyolysis with acute renal injury, and hepatorenal syndrome. It is concluded that it is imperative that use of dietary supplements be monitored closely in all patients. Health care practitioners must take an active role in identifying patients who are using CAM and provide appropriate patient education.
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78 FR 71613 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-11-29
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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77 FR 73654 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2012-12-11
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 9917 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-02-12
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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77 FR 47844 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2012-08-10
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 23934 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-04-23
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 53457 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-08-29
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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77 FR 67012 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2012-11-08
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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77 FR 65888 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2012-10-31
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 63476 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-10-24
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 52915 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-08-27
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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77 FR 65690 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2012-10-30
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 72086 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-12-02
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 68840 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-11-15
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 9694 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-02-11
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 59031 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-09-25
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 61960 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-10-08
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 11186 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-02-15
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 23935 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-04-23
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 69416 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-11-19
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 18340 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-03-26
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 44122 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-07-23
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 69852 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-11-21
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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77 FR 37907 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2012-06-25
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 77684 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-12-24
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 57854 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-09-20
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 76146 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-12-16
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 58538 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-09-24
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 77465 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-12-23
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 54896 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-09-06
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 54647 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-09-05
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 28597 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-05-15
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 66006 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-11-04
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 5179 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-01-24
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 62302 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-10-15
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 73862 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-12-09
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 35930 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-06-14
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 65649 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-11-01
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 68445 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-11-14
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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77 FR 60996 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2012-10-05
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 64498 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-10-29
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 41929 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-07-12
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 15952 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-03-13
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 19709 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-04-02
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 73539 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-12-06
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 67363 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-11-12
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 71612 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-11-29
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 37541 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-06-21
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 21949 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-04-12
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 17930 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-03-25
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 1212 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-01-08
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 51726 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-08-21
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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77 FR 35681 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2012-06-14
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 62363 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-10-21
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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78 FR 11647 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-02-19
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 21368 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-04-10
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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77 FR 19287 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2012-03-30
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR Part 225), and all other applicable statutes and regulations to become a...
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77 FR 20022 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2012-04-03
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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78 FR 15014 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies
2013-03-08
... FEDERAL RESERVE SYSTEM Formations of, Acquisitions by, and Mergers of Bank Holding Companies The companies listed in this notice have applied to the Board for approval, pursuant to the Bank Holding Company Act of 1956 (12 U.S.C. 1841 et seq.) (BHC Act), Regulation Y (12 CFR part 225), and all other applicable statutes and regulations to become a...
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Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in Liver Toxicity Markers
Directory of Open Access Journals (Sweden)
Leticia Riverón-Negrete
2016-01-01
Full Text Available Pharmacological concentrations of biotin have pleiotropic effects. Several reports have documented that biotin supplementation decreases hyperglycemia. We have shown that a biotin-supplemented diet increased insulin secretion and the mRNA abundance of proteins regulating insulin transcription and secretion. We also found enlarged pancreatic islets and modified islet morphology. Other studies have shown that pharmacological concentrations of biotin modify tissue structure. Although biotin administration is considered safe, little attention has been given to its effect on tissue structure. In this study, we investigated the effect of biotin supplementation on hepatic morphology and liver toxicity markers. Male BALB/cAnN Hsd mice were fed a control or a biotin-supplemented diet for 8 weeks. Versus the control mice, biotin-supplemented mice had an altered portal triad with dilated sinusoids, increased vascularity, and bile conducts. Furthermore, we observed an increased proportion of nucleomegaly and binucleated hepatocytes. In spite of the liver morphological changes, no differences were observed in the serum liver damage indicators, oxidative stress markers, or antioxidant enzymes. Our data demonstrate for the first time that biotin supplementation affects liver morphology in normal mice, and that these modifications are not paralleled with damage markers.
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Riverón-Negrete, Leticia; Sicilia-Argumedo, Gloria; Álvarez-Delgado, Carolina; Coballase-Urrutia, Elvia; Alcántar-Fernández, Jonathan; Fernandez-Mejia, Cristina
2016-01-01
Pharmacological concentrations of biotin have pleiotropic effects. Several reports have documented that biotin supplementation decreases hyperglycemia. We have shown that a biotin-supplemented diet increased insulin secretion and the mRNA abundance of proteins regulating insulin transcription and secretion. We also found enlarged pancreatic islets and modified islet morphology. Other studies have shown that pharmacological concentrations of biotin modify tissue structure. Although biotin administration is considered safe, little attention has been given to its effect on tissue structure. In this study, we investigated the effect of biotin supplementation on hepatic morphology and liver toxicity markers. Male BALB/cAnN Hsd mice were fed a control or a biotin-supplemented diet for 8 weeks. Versus the control mice, biotin-supplemented mice had an altered portal triad with dilated sinusoids, increased vascularity, and bile conducts. Furthermore, we observed an increased proportion of nucleomegaly and binucleated hepatocytes. In spite of the liver morphological changes, no differences were observed in the serum liver damage indicators, oxidative stress markers, or antioxidant enzymes. Our data demonstrate for the first time that biotin supplementation affects liver morphology in normal mice, and that these modifications are not paralleled with damage markers.
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2013-01-03
... that is necessary to satisfy GSA pricing policy requirements. The 1364A-1 is a checklist that addresses... Acquisition Policy Division, GSA (816) 823-2170 or via email at [email protected] . SUPPLEMENTARY... fixed pricing for initial tenant improvements, uses GSA Form 1364C. The 1364C captures an offeror's...
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Li, Xiang-Wen; Li, Fang; Liu, Jing; Wang, Yan; Fu, Wei
2016-11-01
To study the possible effect of antepartum taurine supplementation in regulating the activity of Rho family factors and promoting the proliferation of neural stem cells in neonatal rats with fetal growth restriction (FGR), and to provide a basis for antepartum taurine supplementation to promote brain development in children with FGR. A total of 24 pregnant Sprague-Dawley rats were randomly divided into three groups: control, FGR, and taurine (n=8 each ). A rat model of FGR was established by food restriction throughout pregnancy. RT-PCR, immunohistochemistry, and Western blot were used to measure the expression of the specific intracellular markers for neural stem cells fatty acid binding protein 7 (FABP7), Rho-associated coiled-coil containing protein kinase 2 (ROCK2), ras homolog gene family, member A (RhoA), and Ras-related C3 botulinum toxin substrate (Rac). The FGR group had significantly lower OD value of FABP7-positive cells and mRNA and protein expression of FABP7 than the control group, and the taurine group had significantly higher OD value of FABP7-positive cells and mRNA and protein expression of FABP7 than the FGR group (Ptaurine group had significantly higher mRNA expression of RhoA and ROCK2 than the control group and significantly lower expression than the FGR group (Ptaurine group had significantly higher mRNA expression of Rac than the FGR and control groups (Ptaurine group had significantly lower protein expression of RhoA and ROCK2 than the FGR group (Ptaurine supplementation can promote the proliferation of neural stem cells in rats with FGR, and its mechanism may be related to the regulation of the activity of Rho family factors.
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New diffusion imaging method with a single acquisition sequence
International Nuclear Information System (INIS)
Melki, Ph.S.; Bittoun, J.; Lefevre, J.E.
1987-01-01
The apparent diffusion coefficient (ADC) is related to the molecular diffusion coefficient and to physiologic information: microcirculation in the capillary network, incoherent slow flow, and restricted diffusion. The authors present a new MR imaging sequence that yields computed ADC images in only one acquisition of 9-minutes with a 1.5-T imager (GE Signa). Compared to the previous method, this sequence is at least two times faster and thus can be used as a routine examination to supplement T1-, T2-, and density-weighted images. The method was assessed by measurement of the molecular diffusion in liquids, and the first clinical images obtained in neurologic diseases demonstrate its efficiency for clinical investigation. The possibility of separately imaging diffusion and perfusion is supported by an algorithm
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Complementarity in dietary supplements and foods: are supplement users vegetable eaters?
Kang, Hyoung-Goo; Joo, Hailey Hayeon; Choi, Kyong Duk; Lee, Dongmin; Moon, Junghoon
2017-01-01
Background : The consumption of fruits, vegetables, and dietary supplements correlate. Most previous studies have aimed to identify the determinants of supplement uses or the distinct features of supplement users; this literature lacks a discussion on dietary supplement consumption as a predictor of fruit and vegetable consumption. Objective : This study examines how dietary supplement consumption correlates with fruit and vegetable consumption by combining scanner data and surveys of Korean household grocery shopping. Methods : Propensity score matching (PSM) is used to identify the relationship between dietary supplement consumption and fruit and vegetable consumption in a household. A logit regression using supplement consumption as the dependent variable is used. Then, the supplement takers (the treatment group) are matched with non-takers (the control group) based on the propensity scores estimated in the logit regression. The fruit and vegetable consumption levels of the groups are then compared. Results : We found that dietary supplement use is associated with higher fruit and vegetable consumption. This supports the health consciousness hypothesis based on attention bias, availability heuristics, the focusing effect, and the consumption episode effect. It rejects the health substitute hypothesis based on economic substitutes and mental accounting. Conclusions : Future research on the health benefits of dietary supplements should address the complementary consumption of fruits/vegetables and their health benefits to avoid misstating the health effects of supplements.
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31 CFR 355.15 - Can these regulations be amended?
2010-07-01
... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Can these regulations be amended? 355.15 Section 355.15 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... CHECKS § 355.15 Can these regulations be amended? We may, at any time, supplement, amend, or revise the...
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41 CFR 115-1.108 - Agency implementation and supplementation of FPMR.
2010-07-01
... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Agency implementation and supplementation of FPMR. 115-1.108 Section 115-1.108 Public Contracts and Property Management Federal Property Management Regulations System (Continued) ENVIRONMENTAL PROTECTION AGENCY 1-INTRODUCTION...
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Caffeine Toxicity Due to Supplement Use in Caffeine--Naïve Individual: A Cautionary Tale.
Lystrup, Robert M; Leggit, Jeffery C
2015-08-01
Thousands of military members self-medicate with dietary supplements containing unknown quantities of pharmacologically active compounds. These poorly regulated substances can cause real harm to the military population, especially when they contain stimulants such as caffeine. When taken regularly, caffeine has several performance-enhancing benefits. However, when used excessively or in vulnerable populations, caffeine can cause several unwanted side effects such as nervousness, sensory disturbances, insomnia, arrhythmia, excitability, inattentiveness, restlessness, mood changes, gastrointestinal disturbances, and even psychosis. Vulnerable patients include the caffeine-naïve, physiologically stressed, young, and mentally ill patients. One such case describes a caffeine-naïve service member who suffered an adverse reaction after taking an allegedly moderate dose of caffeine from a pill he obtained from a teammate. This case highlights the importance of supplement awareness among service members, increased provider vigilance, third party verification, and enhanced regulation on the approval and marketing of dietary supplements. Reprint & Copyright © 2015 Association of Military Surgeons of the U.S.