WorldWideScience

Sample records for regulation supplement acquisition

  1. 78 FR 68829 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Contract...

    Science.gov (United States)

    2013-11-15

    ... DFARS 252.232-7007, Limitation of Government's Obligation. DFARS subpart 232.7, Contract [[Page 68830...; Defense Federal Acquisition Regulation Supplement; Contract Financing AGENCY: Defense Acquisition... and OMB Number: Defense Federal Acquisition Regulation Supplement (DFARS) Part 232, Contract Financing...

  2. 75 FR 52650 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items (2008-D011)

    Science.gov (United States)

    2010-08-27

    ...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Interim rule; delay in... rule that amended the Defense Federal Acquisition Regulation Supplement (DFARS) to implement sections... comments on the interim rule were located, which had not been addressed in finalization of the interim rule...

  3. 77 FR 2680 - Defense Federal Acquisition Regulation Supplement; Definition of Cost or Pricing Data

    Science.gov (United States)

    2012-01-19

    ... Regulation Supplement; Definition of Cost or Pricing Data AGENCY: Defense Acquisition Regulations System... Acquisition Regulation Supplement (DFARS) to update text addressing the definition of cost or pricing data... update the DFARS for consistency with FAR changes addressing the definition of cost or pricing data...

  4. 77 FR 13013 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2012-03-05

    ... Organization Government Procurement Agreement and the Free Trade Agreements, as determined by the United States... 252 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System...

  5. 76 FR 13297 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2011-03-11

    ... 215 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System... Director, Defense Procurement and Acquisition Policy. DATES: Effective Date: March 11, 2011. Applicability... adding a section at 215.300 with a reference to Director, Defense Procurement and Acquisition Policy...

  6. 75 FR 33237 - Defense Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS...

    Science.gov (United States)

    2010-06-11

    ... Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS Case 2009-D025) AGENCY: Defense.../Pension Review from Procedures, Guidance, and Information to the Defense Acquisition Regulation Supplement..., February 23, 2006, moved requirements for Contractor Insurance/Pension Review (CIPR) from DFARS 242.7302 to...

  7. 76 FR 71465 - Defense Federal Acquisition Regulation Supplement: Management of Manufacturing Risk in Major...

    Science.gov (United States)

    2011-11-18

    ... Government procurement. Mary Overstreet, Editor, Defense Acquisition Regulations System. Interim Rule Adopted... Federal Acquisition Regulation Supplement: Management of Manufacturing Risk in Major Defense Acquisition...). ACTION: Final rule. SUMMARY: DoD is adopting as final, without change, an interim rule amending the...

  8. 75 FR 3178 - Defense Federal Acquisition Regulation Supplement; Lead System Integrators

    Science.gov (United States)

    2010-01-20

    ... Government procurement. Amy G. Williams, Editor, Defense Acquisition Regulations System. 0 Accordingly, the..., without change, an interim rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to... limitations on the award of new contracts for lead system integrator functions in the acquisition of major DoD...

  9. 76 FR 59623 - Defense Federal Acquisition Regulation Supplement; Only One Offer (DFARS Case 2011-D013)

    Science.gov (United States)

    2011-09-27

    ..., 215, 216, and 252 RIN 0750-AH11 Defense Federal Acquisition Regulation Supplement; Only One Offer... Supplement (DFARS) to address acquisitions using competitive procedures in which only one offer is received... days, if the solicitation allowed fewer than 30 days for receipt of proposals and only one offer is...

  10. 76 FR 71468 - Defense Federal Acquisition Regulation Supplement: Accelerate Small Business Payments (DFARS Case...

    Science.gov (United States)

    2011-11-18

    ... all small business concerns. In combination with the change to the regulations, DoD immediately began... Federal Acquisition Regulation Supplement: Accelerate Small Business Payments (DFARS Case 2011-D008... Regulation Supplement to accelerate payments to all small business concerns. DATES: Effective Date: November...

  11. 75 FR 71560 - Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting System (DFARS...

    Science.gov (United States)

    2010-11-24

    ... also asked what allowance is provided for contractors with accounting software that does not... RIN 0750-AG46 Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting... Regulation Supplement (DFARS) to address DoD Cost and Software Data Reporting system requirements for Major...

  12. 75 FR 18041 - Defense Federal Acquisition Regulation Supplement; Minimizing Use of Hexavalent Chromium (DFARS...

    Science.gov (United States)

    2010-04-08

    ...-AG35 Defense Federal Acquisition Regulation Supplement; Minimizing Use of Hexavalent Chromium (DFARS... Regulation Supplement (DFARS) to address requirements for minimizing the use of hexavalent chromium in... of items containing hexavalent chromium under DoD contracts unless an exception applies. DATES...

  13. 75 FR 75549 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-03

    ..., et al. Defense Federal Acquisition Regulation Supplement; Business Systems-- Definition and... Regulation Supplement; Business Systems--Definition and Administration (DFARS Case 2009-D038) AGENCY: Defense.... SUPPLEMENTARY INFORMATION: I. Background DoD published a proposed rule for Business Systems--Definition and...

  14. 78 FR 18877 - Defense Federal Acquisition Regulation Supplement: New Free Trade Agreement With Colombia (DFARS...

    Science.gov (United States)

    2013-03-28

    ... Federal Acquisition Regulation Supplement: New Free Trade Agreement With Colombia (DFARS Case 2012-D032... Regulation Supplement (DFARS) to implement the United States-Colombia Trade Promotion Agreement. This Trade Promotion Agreement is a free trade agreement that provides for mutually non-discriminatory treatment of...

  15. 77 FR 4632 - Defense Federal Acquisition Regulation Supplement; Independent Research and Development Technical...

    Science.gov (United States)

    2012-01-30

    ... Federal Acquisition Regulation Supplement; Independent Research and Development Technical Descriptions... Regulation Supplement (DFARS) to require major contractors to report independent research and development (IR... 11414 on March 2, 2011, to revise requirements for reporting IR&D projects to the Defense Technical...

  16. 77 FR 11367 - Defense Federal Acquisition Regulation Supplement; Extension of the Test Program for Negotiation...

    Science.gov (United States)

    2012-02-24

    ...DoD is issuing a final rule amending the Defense Federal Acquisition Regulation Supplement to extend the program period for the DoD Test Program for Negotiation of Comprehensive Small Business Subcontracting Plans.

  17. 76 FR 44282 - Defense Federal Acquisition Regulation Supplement; Prohibition on Interrogation of Detainees by...

    Science.gov (United States)

    2011-07-25

    ...-AG88 Defense Federal Acquisition Regulation Supplement; Prohibition on Interrogation of Detainees by... prescribes policies prohibiting interrogation of detainees by contractor personnel, as required by section... ancillary positions, including as trainers of, and advisors to, interrogations, if the contractor personnel...

  18. 77 FR 11355 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2012-02-24

    ...D published an initial proposed rule for Business Systems-- Definition and Administration (DFARS... the definition and administration of contractor business systems as follows: A. Contractor business..., 245, and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems...

  19. 75 FR 66686 - Defense Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption for...

    Science.gov (United States)

    2010-10-29

    ... Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption for Commercial... Balance of Payments Program for construction material that is commercial information technology. DATES... the Balance of Payments Program for commercial information technology to be used in overseas...

  20. 75 FR 65439 - Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting System

    Science.gov (United States)

    2010-10-25

    ... Accounting Service or Missile Defense Agency. (2) For DoD, the authority to acknowledge receipt or reject... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 219 and 252 [DFARS Case 2009-D002] Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting...

  1. 78 FR 65218 - Defense Federal Acquisition Regulation Supplement: Private Sector Notification Requirements of In...

    Science.gov (United States)

    2013-10-31

    ... Federal Acquisition Regulation Supplement: Private Sector Notification Requirements of In-Sourcing Actions... Supplement (DFARS) to implement a section of the National Defense Authorization Act regarding private sector... section 938 of the National Defense Authorization Act (NDAA) for Fiscal Year 2012 regarding private sector...

  2. 78 FR 48404 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Contract Financing...

    Science.gov (United States)

    2013-08-08

    ...-AI02 Defense Federal Acquisition Regulation Supplement: Clauses With Alternates--Contract Financing... Supplement (DFARS) to create an overarching prescription for the set of contract financing related clauses... amend the DFARS to create an overarching prescription for the contract financing clause with one...

  3. 78 FR 63462 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Science.gov (United States)

    2013-10-24

    ... Relating to Organizational Conflict of Interest-Major Defense Acquisition Program; OMB Control Number 0704...] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Organizational Conflict... submit comments, identified by OMB Control Number 0704-0477, using any of the following methods: [cir...

  4. 76 FR 14588 - Defense Federal Acquisition Regulation Supplement; Nonavailability Exception for Procurement of...

    Science.gov (United States)

    2011-03-17

    ... Federal Acquisition Regulation Supplement; Nonavailability Exception for Procurement of Hand or Measuring... Subjects in 48 CFR Part 225 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition... requirement at 10 U.S.C. 2533a (Berry Amendment) to acquire only domestic hand or measuring tools. DATES...

  5. 76 FR 57677 - Defense Federal Acquisition Regulation Supplement; Increase the Use of Fixed-Price Incentive...

    Science.gov (United States)

    2011-09-16

    ...] RIN 0750-AH15 Defense Federal Acquisition Regulation Supplement; Increase the Use of Fixed-Price...-price incentive (firm target) contracts, with particular attention to share lines and ceiling prices... the use of fixed-price incentive (firm target) contracts, especially for acquisitions moving from...

  6. 75 FR 54524 - Defense Federal Acquisition Regulation Supplement; Acquisition Strategies To Ensure Competition...

    Science.gov (United States)

    2010-09-08

    ...., because the changes are to internal Government organization and operating procedures only. The rule... 48 CFR Part 207 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations... Life Cycle of Major Defense Acquisition Programs (DFARS Case 2009-D014) AGENCY: Defense Acquisition...

  7. 76 FR 75875 - Defense Federal Acquisition Regulation Supplement; Open Source Software Public Meeting

    Science.gov (United States)

    2011-12-05

    ... Regulation Supplement; Open Source Software Public Meeting AGENCY: Defense Acquisition Regulations System... initiate a dialogue with industry regarding the use of open source software in DoD contracts. DATES: Public... to the risks to the contractors and the Government associated with using open source software on DoD...

  8. 77 FR 39125 - Defense Acquisition Regulations System; Defense Federal Acquisition Regulation Supplement; Only...

    Science.gov (United States)

    2012-06-29

    ... market research/industry communication. In 2008, the Office of Management and Budget and Office of... unique or brand name specifications, and enhancing acquisition planning. In 2010, the Government... strategic defense capabilities, because of a shift to ``lowest price possible.'' Further, according to this...

  9. 75 FR 59103 - Defense Federal Acquisition Regulation Supplement; Motor Carrier Fuel Surcharge (DFARS Case 2008...

    Science.gov (United States)

    2010-09-27

    ...-AG30 Defense Federal Acquisition Regulation Supplement; Motor Carrier Fuel Surcharge (DFARS Case 2008... comments is provided below: 1. Comment. One respondent stated that it is customary in the motor carrier freight industry to assume a fixed cost of diesel fuel with a cost recovery mechanism (fuel surcharge) for...

  10. 76 FR 71926 - Defense Federal Acquisition Regulation Supplement: Applicability of Hexavalent Chromium Policy to...

    Science.gov (United States)

    2011-11-21

    ... 0750-AH39 Defense Federal Acquisition Regulation Supplement: Applicability of Hexavalent Chromium... the use of materials containing hexavalent chromium. DATES: Comment Date: Comments on the proposed... human health and environmental risks related to the use of hexavalent chromium. Hexavalent chromium is a...

  11. 76 FR 58122 - Defense Federal Acquisition Regulation Supplement; Material Inspection and Receiving Report...

    Science.gov (United States)

    2011-09-20

    ... acceptance point and replacing it with more specific data entries for inspection, acceptance, and ship to Do..., acceptance, and ship-to fields but kept the source, destination, and other inspection and acceptance points... Acquisition Regulation Supplement; Material Inspection and Receiving Report (DFARS Case 2009-D023) AGENCY...

  12. 76 FR 58155 - Defense Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Services...

    Science.gov (United States)

    2011-09-20

    ... Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Services Performance... performance evaluations for construction and architect-engineer services. DATES: Effective Date: September 20... past performance for construction and Architect- Engineer services. On April 19, 2011, DoD published a...

  13. 75 FR 67632 - Defense Federal Acquisition Regulation Supplement; Prohibition on Interrogation of Detainees by...

    Science.gov (United States)

    2010-11-03

    ...-AG88 Defense Federal Acquisition Regulation Supplement; Prohibition on Interrogation of Detainees by... National Defense Authorization Act for Fiscal Year 2010 (Pub. L. 111-84) prohibits the interrogation of..., to add DFARS 237.173, Prohibition on Interrogation of Detainees by Contractor Personnel, adding a...

  14. 77 FR 2682 - Defense Federal Acquisition Regulation Supplement; DoD Voucher Processing

    Science.gov (United States)

    2012-01-19

    ... provisional payment and sent to the disbursing office after a pre- payment review. Interim vouchers not... after a pre-payment review. Interim vouchers not selected for a pre-payment review will be considered to...] RIN 0750-AH52 Defense Federal Acquisition Regulation Supplement; DoD Voucher Processing AGENCY...

  15. 75 FR 3179 - Defense Federal Acquisition Regulation Supplement; Trade Agreements-Costa Rica and Peru (DFARS...

    Science.gov (United States)

    2010-01-20

    ...-AG31 Defense Federal Acquisition Regulation Supplement; Trade Agreements--Costa Rica and Peru (DFARS... respect to Costa Rica, and the United States-Peru Trade Promotion Agreement. The trade agreements waive... States Free Trade Agreement with respect to Costa Rica and the United States-Peru Trade Promotion...

  16. 76 FR 9680 - Defense Federal Acquisition Regulation Supplement; Repeal of the Small Business Competitiveness...

    Science.gov (United States)

    2011-02-22

    ... Federal Acquisition Regulation Supplement; Repeal of the Small Business Competitiveness Demonstration... the Small Business Competitiveness Demonstration Program. DATES: Effective Date: February 22, 2011...-656) by striking title VII (15 U.S.C. 644 note). The repeal of the Small Business Competitiveness...

  17. 76 FR 38053 - Defense Federal Acquisition Regulation Supplement; Successor Entities to the Netherlands Antilles...

    Science.gov (United States)

    2011-06-29

    ... Federal Acquisition Regulation Supplement; Successor Entities to the Netherlands Antilles (DFARS Case 2011... ``designated country'' due to the change in the political status of the islands that comprised the Netherlands..., 2010, Curacao and Sint Maarten became autonomous territories of the Kingdom of the Netherlands. Bonaire...

  18. 75 FR 71564 - Defense Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS...

    Science.gov (United States)

    2010-11-24

    ... Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS Case 2009-D025... conducting a Contractor Insurance/Pension Review from Procedures, Guidance, and Information (PGI) to the... This final rule relocates requirements for Contractor Insurance/ Pension Review to DFARS 242.7302 from...

  19. 76 FR 14589 - Defense Federal Acquisition Regulation Supplement; Repeal of Restriction on Ballistic Missile...

    Science.gov (United States)

    2011-03-17

    ...-AH18 Defense Federal Acquisition Regulation Supplement; Repeal of Restriction on Ballistic Missile...). Section 222 repeals the restriction on purchase of Ballistic Missile Defense research, development, test... Ballistic Missile Defense research, development, test, and evaluation that was required by section 222 of...

  20. 76 FR 28855 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration

    Science.gov (United States)

    2011-05-18

    ...; Business Systems-- Definition and Administration; Interim Rule #0;#0;Federal Register / Vol. 76 , No. 96...-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration... an initial proposed rule for Business Systems-- Definition and Administration (DFARS Case 2009-D038...

  1. 75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-12-09

    ..., and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition... for Business Systems--Definition and Administration (DFARS Case 2009-D038) in the Federal Register on... improve the effectiveness of DoD oversight of contractor business systems. The comment period is being...

  2. 76 FR 38051 - Defense Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010...

    Science.gov (United States)

    2011-06-29

    ... Sexual Assault/Harassment Involving DoD Contractors During Contingency Operations,'' dated April 16, 2010... Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY... employees accompanying U.S. Armed Forces are made aware of the DoD definition of sexual assault as defined...

  3. 75 FR 73997 - Defense Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010...

    Science.gov (United States)

    2010-11-30

    ... Inspector General audit D-2010-052, entitled ``Efforts to Prevent Sexual Assault/Harassment Involving DoD... Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY: Defense..., to ensure contractor employees are aware of the DoD definition of ``sexual assault'' as defined in Do...

  4. 78 FR 30233 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Science.gov (United States)

    2013-05-22

    ... Number 0750-AG38 Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access... Government support contractors to have access to proprietary technical data belonging to prime contractors and other third parties, provided that the technical data owner may require the support contractor to...

  5. 77 FR 14490 - Defense Federal Acquisition Regulation Supplement: Alleged Crimes By or Against Contractor...

    Science.gov (United States)

    2012-03-12

    ... Federal Acquisition Regulation Supplement: Alleged Crimes By or Against Contractor Personnel (DFARS Case... (DFARS) to expand coverage on contractor requirements and responsibilities relating to alleged crimes by or against contractor personnel. DATES: Comment Date: Comments on the proposed rule should be...

  6. 78 FR 59851 - Defense Federal Acquisition Regulation Supplement: Enhancement of Contractor Employee...

    Science.gov (United States)

    2013-09-30

    ...-AH97 Defense Federal Acquisition Regulation Supplement: Enhancement of Contractor Employee... contractor and subcontractor employees. DATES: Effective date: September 30, 2013. In accordance with FAR 1... Whistleblower Protections for Contractor Employees) made extensive changes to 10 U.S.C. 2409, entitled...

  7. 75 FR 66680 - Defense Federal Acquisition Regulation Supplement (DFARS); Continuation of Essential Contractor...

    Science.gov (United States)

    2010-10-29

    ...-AG52 Defense Federal Acquisition Regulation Supplement (DFARS); Continuation of Essential Contractor... that contractors providing essential contractor services, as determined by the requiring activity..., implementing the requirements of DoDI 3020.37, Continuation of Essential DoD Contractor Services During Crises...

  8. 76 FR 14590 - Defense Federal Acquisition Regulation Supplement; Safety of Facilities, Infrastructure, and...

    Science.gov (United States)

    2011-03-17

    ... makes it unlikely that a small business could afford to sustain the infrastructure required to perform...-AG73 Defense Federal Acquisition Regulation Supplement; Safety of Facilities, Infrastructure, and... facilities, infrastructure, and equipment that are intended for use by military or civilian personnel of the...

  9. 76 FR 11414 - Defense Federal Acquisition Regulation Supplement; Independent Research and Development Technical...

    Science.gov (United States)

    2011-03-02

    ... Acquisition Regulation Supplement; Independent Research and Development Technical Descriptions (DFARS Case... (DFARS) to require contractors to report independent research and development (IR&D) projects generating... to the Defense Technical Information Center (DTIC). Beginning in the 1990s, DoD reduced its technical...

  10. 76 FR 3536 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2011-01-20

    ... concerns, HUBZone small business concerns, small disadvantaged business concerns, women-owned small... date, and revising paragraph (a)(10) to read as follows: 252.225-7009 Restriction on Acqusition of Certain Articles Containing Specialty Metals. * * * * * RESTRICTION ON ACQUISITION OF CERTAIN ARTICLES...

  11. 76 FR 32841 - Defense Federal Acquisition Regulation Supplement; Foreign Acquisition Amendments (DFARS Case...

    Science.gov (United States)

    2011-06-06

    ..., eligibility of Peruvian end products under trade agreements, and participation of foreign contractors in... contractors in acquisitions in support of operations in Afghanistan, and eligibility of Peruvian end products....225-7045, Balance of Payments Program--Construction Material Under Trade Agreements. This final rule...

  12. 75 FR 81915 - Defense Federal Acquisition Regulation Supplement; Foreign Participation in Acquisitions in...

    Science.gov (United States)

    2010-12-29

    ... prescriptions. Amends 225.1101(6)(i) to reference the World Trade Organization (WTO) Government Procurement... Subjects in 48 CFR Parts 225 and 252 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition... paragraph (c)(iii) to read as follows: 225.403 World Trade Organization Government Procurement Agreement and...

  13. 76 FR 57671 - Defense Federal Acquisition Regulation Supplement; Display of DoD Inspector General Fraud Hotline...

    Science.gov (United States)

    2011-09-16

    ... the title of the applicable Department of Homeland Security (DHS) fraud hotline poster and Web site(s... General Fraud Hotline Posters AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... Regulation Supplement (DFARS) to require contractors to display the DoD fraud hotline poster in common work...

  14. 75 FR 33752 - Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest in Major...

    Science.gov (United States)

    2010-06-15

    ... Conflicts of Interest in Major Defense Acquisition Programs AGENCY: Defense Acquisition Regulations System... extended an additional 30 days to provide additional time for interested parties to review the proposed... interested parties to review the proposed DFARS changes. Ynette R. Shelkin, Editor, Defense Acquisition...

  15. 77 FR 20598 - Defense Federal Acquisition Regulation Supplement: Solicitation Provisions and Contract Clauses...

    Science.gov (United States)

    2012-04-05

    ... commercial items, that includes the clause at 252.225-7001, Buy American Act and Balance of Payments Program... Acquisitions of Commercial Items AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... acquisition of commercial items and to specify flowdown of clauses to commercial subcontracts. DATES: Comments...

  16. 76 FR 13327 - Defense Federal Acquisition Regulation Supplement; Display of DoD Inspector General Fraud Hotline...

    Science.gov (United States)

    2011-03-11

    ..., Washington, DC 22202-2884. (ii) Department of Homeland Security (DHS) fraud hotline poster identified in... _________ _________ _________ _________ (Contracting Officer shall insert-- (i) Title of applicable Department of Homeland Security fraud hotline...-AG98 Defense Federal Acquisition Regulation Supplement; Display of DoD Inspector General Fraud Hotline...

  17. 75 FR 71563 - Defense Federal Acquisition Regulation Supplement; Services of Senior Mentors (DFARS Case 2010-D025)

    Science.gov (United States)

    2010-11-24

    ... mentoring, teaching, training, advice, and recommendations to senior military officers, staff, and students... Acquisition Regulation Supplement; Services of Senior Mentors (DFARS Case 2010-D025) AGENCY: Defense... policy on the services of senior mentors. DATES: Effective: November 24, 2010. FOR FURTHER INFORMATION...

  18. 75 FR 54527 - Defense Federal Acquisition Regulation Supplement; Government Rights in the Design of DoD Vessels...

    Science.gov (United States)

    2010-09-08

    ...-AG50 Defense Federal Acquisition Regulation Supplement; Government Rights in the Design of DoD Vessels.... Section 825 clarifies the Government's rights in technical data in the designs of a DoD vessel, boat... cite DFARS Case 2008-D039. SUPPLEMENTARY INFORMATION: A. Background This final rule implements section...

  19. 77 FR 76938 - Defense Federal Acquisition Regulation Supplement: Contracting Activity Updates (DFARS Case 2012...

    Science.gov (United States)

    2012-12-31

    ... Security Cooperation Agency, the Defense Security Service, the Defense Threat Reduction Agency, the Missile... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 202 RIN 0750-AH81 Defense...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is...

  20. 78 FR 20624 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Science.gov (United States)

    2013-04-05

    ... Identification Advance Shipment Notices AGENCY: Defense Acquisition Regulations System, Department of Defense (Do...) Whether the proposed collection of information is necessary for the proper performance of the functions of... at 252.211; Radio Frequency Identification Advance Shipment Notices, OMB Control Number 0704-0434...

  1. 78 FR 36108 - Defense Federal Acquisition Regulation Supplement; Defense Trade Cooperation Treaties With...

    Science.gov (United States)

    2013-06-17

    ... and for foreign firms in their supply chains. The U.S. concluded the DTC Treaties with Australia and... respondent commended the Defense Acquisition Regulations (DAR) Council on recognizing the importance of the... established a Management Board to resolve such issues, adopted a detailed management plan, and conducted...

  2. 75 FR 32640 - Defense Federal Acquisition Regulation Supplement; Finland- Public Interest Exception to the Buy...

    Science.gov (United States)

    2010-06-08

    ... procurement memorandum of understanding (RDP MOU) between the government of Finland and the Government of the United States has been in effect since 1991. The governments have negotiated and concluded a new RDP MOU... Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System. 0 Therefore, 48...

  3. 75 FR 33271 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Foreign...

    Science.gov (United States)

    2010-06-11

    ... Certain Contracts with Foreign Entities for the Conduct of Ballistic Missile Defense Research, Development..., development, test, or evaluation in connection with the Ballistic Missile Defense Program. The provision... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0229...

  4. 78 FR 69267 - Defense Federal Acquisition Regulation Supplement: Requirements Relating to Supply Chain Risk...

    Science.gov (United States)

    2013-11-18

    ... payroll, finance, logistics, and personnel management applications; or (2) Is protected at all times by... recommendation from the Under Secretary of Defense for Acquisition, Technology, and Logistics (USD(AT&L)) and the... assess all costs and benefits of available regulatory alternatives and, if regulation is necessary, to...

  5. 78 FR 15935 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Science.gov (United States)

    2013-03-13

    ... automated collection techniques or other forms of information technology. The Office of Management and... construction contract in Spain has adequate insurance coverage. Affected Public: Businesses or other for profit... construction contract in Spain. Kortnee Stewart, Editor, Defense Acquisition Regulations System. [FR Doc. 2013...

  6. 78 FR 13547 - Defense Federal Acquisition Regulation Supplement: Alleged Crimes By or Against Contractor Personnel

    Science.gov (United States)

    2013-02-28

    ... Contractor Personnel AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION... (FY) 2009 and expand coverage on contractor requirements and responsibilities relating to alleged crimes by or against contractor personnel. DATES: Effective February 28, 2013. FOR FURTHER INFORMATION...

  7. 77 FR 30368 - Defense Federal Acquisition Regulation Supplement; Utilization of Domestic Photovoltaic Devices...

    Science.gov (United States)

    2012-05-22

    ... arrangement, the Government would take title to the devices during contract performance or at the conclusion... rule will promote utilization of domestic photovoltaic devices, even when the Government does not take... Devices (DFARS Case 2011-D046) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD...

  8. 75 FR 26739 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Part 244...

    Science.gov (United States)

    2010-05-12

    ... Control Number 0704-0253) AGENCY: Defense Acquisition Regulations System, Department of Defense. ACTION... proposed information collection; (c) ways to enhance the quality, utility, and clarity of the information..., withhold, or withdraw purchasing system approval at the conclusion of a purchasing system review...

  9. 78 FR 70025 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Science.gov (United States)

    2013-11-22

    ... and Procedures AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION... proposed information collection; (c) ways to enhance the quality, utility, and clarity of the information..., withhold, or withdraw purchasing system approval at the conclusion of a purchasing system review...

  10. 77 FR 76939 - Defense Federal Acquisition Regulation Supplement: Definition of Cost or Pricing Data (DFARS Case...

    Science.gov (United States)

    2012-12-31

    ... cost or pricing data'' in its place. PART 217--SPECIAL CONTRACTING METHODS 217.7401 [Amended] 0 11... Cost or Pricing Data (DFARS Case 2011-D040) AGENCY: Defense Acquisition Regulations System, Department... ``certified cost or pricing data'' and ``data other than certified cost or pricing data.'' The DFARS changes...

  11. 76 FR 25566 - Defense Federal Acquisition Regulation Supplement (DFARS); Electronic Ordering Procedures (DFARS...

    Science.gov (United States)

    2011-05-05

    ... officials to specify e-mail as an ``electronic commerce method'' so long as it is authorized in the schedule... recognized electronic commerce method. The respondent recommended, in the alternative, that the Government... stated that electronic commerce is a term specifically identified in Federal Acquisition Regulation (FAR...

  12. 77 FR 52252 - Defense Federal Acquisition Regulation Supplement: Inflation Adjustment of Threshold for...

    Science.gov (United States)

    2012-08-29

    ... and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance of... Acquisition of Right-Hand Drive Passenger Sedans (DFARS Case 2012-D016) AGENCY: Defense Acquisition... of the statutory dollar limitation on the acquisition of right-hand drive passenger sedans. DATES...

  13. 77 FR 19127 - Defense Federal Acquisition Regulation Supplement; Inflation Adjustment of Threshold for...

    Science.gov (United States)

    2012-03-30

    ... and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance of... Acquisition of Right-Hand Drive Passenger Sedans (DFARS Case 2012-D016) AGENCY: Defense Acquisition... acquisition of right-hand drive passenger sedans be included on the list of dollar thresholds subject to...

  14. 77 FR 58817 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Science.gov (United States)

    2012-09-24

    ... automated collection techniques or other forms of information technology. The Office of Management and... 252.232-7002, Progress Payments for Foreign Military Sales Acquisitions; OMB Control Number 0704-0321.... The clause at 252.232- 7002, Progress Payments for Foreign Military Sales Acquisitions, requires each...

  15. 76 FR 32845 - Defense Federal Acquisition Regulation Supplement; Definition of “Qualifying Country End Product...

    Science.gov (United States)

    2011-06-06

    ... statutes or executive orders applicable to defense acquisitions of commercial items. * * * * * CONTRACT... ACQUISITIONS OF COMMERCIAL ITEMS (DATE) * * * * * (b) * * * (5)(i)--------252.225-7001, Buy American Act and Balance of Payments Program (DATE) (41 U.S.C. chapter 83, E.O. 10582). * * * * * (11)(i)--------252.225...

  16. 75 FR 71647 - Defense Federal Acquisition Regulation Supplement; Discussions Prior to Contract Award (DFARS...

    Science.gov (United States)

    2010-11-24

    ... Deputy Under Secretary of Defense (Acquisition, Technology, and Logistics) to revise the DoD source... misunderstood requirements. DoD notes the potential disadvantages of this proposed change in increased time to...

  17. 75 FR 25160 - Defense Federal Acquisition Regulation Supplement; Marking of Government-Furnished Property...

    Science.gov (United States)

    2010-05-07

    ... to track and trace property items throughout their lifecycle (in acquisition and logistics business... entities to which this rule will apply. DoD invites comments from small business concerns and other...

  18. 78 FR 65221 - Defense Federal Acquisition Regulation Supplement: New Free Trade Agreement-Panama (DFARS Case...

    Science.gov (United States)

    2013-10-31

    ... Supplement (DFARS) to implement the United States--Panama Trade Promotion Agreement. This Trade Promotion...--Panama Trade Promotion Agreement. No respondents submitted public comments in response to the interim... effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance of quantifying both costs...

  19. 78 FR 13606 - Defense Federal Acquisition Regulation Supplement; Unallowable Fringe Benefit Costs (DFARS Case...

    Science.gov (United States)

    2013-02-28

    ... indirect cost is expressly unallowable under a cost principle in the FAR, or an executive agency supplement... economic, environmental, public health and safety effects, distributive impacts, and equity). E.O. 13563... have a significant economic impact on a substantial number of small entities within the meaning of the...

  20. 75 FR 32639 - Defense Federal Acquisition Regulation Supplement; Limitations on Procurements With Non-Defense...

    Science.gov (United States)

    2010-06-08

    ...-DoD agencies that are an element of the intelligence community. B. Discussion The National Security... elements of the Department of Homeland Security concerned with the analysis of intelligence information... for property and services in excess of the simplified acquisition threshold by certain non-DoD...

  1. 76 FR 11361 - Defense Federal Acquisition Regulation Supplement; Preservation of Tooling for Major Defense...

    Science.gov (United States)

    2011-03-02

    ... the ``preservation and storage of unique tooling associated with the production of hardware for a... agrees with the concept to sustain capability and supportability to the extent needed under major weapons... tooling associated with the production of hardware for a major defense acquisition program. DoD thinks...

  2. 76 FR 32839 - Defense Federal Acquisition Regulation Supplement; Agency Office of the Inspector General (DFARS...

    Science.gov (United States)

    2011-06-06

    ... 52.203-13, Contractor Code of Business Ethics and Conduct. This final rule corrects two omissions in... Subjects in 48 CFR Parts 203 and 252 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition... clause 52.203-13, Contractor Code of Business Ethics and Conduct. * * * * * PART 252--SOLICITATION...

  3. 78 FR 18876 - Defense Federal Acquisition Regulation Supplement: United States-Korea Free Trade Agreement...

    Science.gov (United States)

    2013-03-28

    ... Agreement. The Republic of Korea is already party to the World Trade Organization Government Procurement...) Agreement on Government Procurement (GPA). Although the rule now opens up Government procurement to the... 48 CFR Parts 225 and 252 Government procurement. Kortnee Stewart, Editor, Defense Acquisition...

  4. 75 FR 76297 - Defense Federal Acquisition Regulation Supplement; Restriction on Ball and Roller Bearings (DFARS...

    Science.gov (United States)

    2010-12-08

    ... does not have enough market leverage for it to be in the business interest of the manufacturers and... reason for changing the rule is statutory change. 10 U.S.C. 2534(a)(5) is no longer in effect because... Government leverage with regard to acquisition of commercial bearings. The Government continues to issue more...

  5. 76 FR 71467 - Defense Federal Acquisition Regulation Supplement; Extension of Department of Defense Mentor...

    Science.gov (United States)

    2011-11-18

    ... Defense Mentor-Prot[eacute]g[eacute] Pilot Program (DFARS Case 2011-D050) AGENCY: Defense Acquisition... applications under the DoD Mentor-Prot[eacute]g[eacute] Pilot Program for new mentor-prot[eacute]g[eacute] agreements and the date mentors may incur costs and/or receive credit towards fulfilling their small business...

  6. 77 FR 11367 - Defense Federal Acquisition Regulation Supplement; Extension of the Department of Defense Mentor...

    Science.gov (United States)

    2012-02-24

    ... Defense Mentor-Prot[eacute]g[eacute] Pilot Program (DFARS Case 2012-D024) AGENCY: Defense Acquisition... applications under the DoD Mentor-Prot[eacute]g[eacute] Pilot Program for new mentor-prot[eacute]g[eacute] agreements and the date mentors may incur costs and/or receive credit towards fulfilling their small business...

  7. 75 FR 18034 - Defense Federal Acquisition Regulation Supplement; Research and Development Contract Type...

    Science.gov (United States)

    2010-04-08

    ... Budget under 44 U.S.C. 3501, et seq. List of Subjects in 48 CFR Parts 234 and 235 Government procurement...). ACTION: Final rule. SUMMARY: DoD is adopting as final, without change, an interim rule that requires the Milestone Decision Authority (MDA) for a major defense acquisition program (MDAP) to select the contract...

  8. 77 FR 68699 - Defense Federal Acquisition Regulation Supplement: New Free Trade Agreement-Panama (DFARS Case...

    Science.gov (United States)

    2012-11-16

    .... 601, et seq. Although the rule now opens up Government procurement to the goods and services of Panama... Applicability of specified procurement procedures designed to ensure fairness in the acquisition of supplies and... as the WTO GPA threshold, no new clause alternates are required for the Balance of Payments Program...

  9. 78 FR 28756 - Defense Federal Acquisition Regulation Supplement: System for Award Management Name Changes...

    Science.gov (United States)

    2013-05-16

    ... Management Name Changes, Phase 1 Implementation (DFARS Case 2012- D053) AGENCY: Defense Acquisition... Excluded Parties Listing System (EPLS) databases into the System for Award Management (SAM) database. DATES... enacted in an effort to improve the management and promotion of electronic Government services and...

  10. 76 FR 33166 - Defense Federal Acquisition Regulation Supplement (DFARS); Warranty Tracking of Serialized Items...

    Science.gov (United States)

    2011-06-08

    ... traceability of items to a warranty will assist all members of the supply chain to manage risk appropriately. This traceability also leads to ensuring the Government receives the supplies purchased, reducing the... Acquisition, Technology and Logistics dated February 6, 2007, which required definition of the requirements to...

  11. 75 FR 66683 - Defense Federal Acquisition Regulation Supplement; Safety of Facilities, Infrastructure, and...

    Science.gov (United States)

    2010-10-29

    ... States, Guam, Puerto Rico, and the Virgin Islands. DFARS 246.270-2 provides for the rule to apply to each... determination by the Contracting Officer with the concurrence of the relevant Discipline Working Group. The Discipline Working Group is defined in the clause. Section 807 is applicable to contracts for the acquisition...

  12. 78 FR 73475 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Research and...

    Science.gov (United States)

    2013-12-06

    ... alternate, and to include in the regulation the full text of the alternate clause. DATES: Comment date... provide each alternate clause in full text in the regulation. The inclusion of the full text of the... from from the basic clause. Placing the alternate clause in full text in the regulation will clarify...

  13. 77 FR 4629 - Defense Federal Acquisition Regulation Supplement; Trade Agreements Thresholds (DFARS Case 2012...

    Science.gov (United States)

    2012-01-30

    ...: Australia FTA 77,494 7,777,000 Bahrain FTA 202,000 10,074,262 CAFTA-DR (Costa Rica, Dominican 77,494 7,777... 202,000 7,777,000 NAFTA: --Canada 25,000 10,074,262 --Mexico 77,494 10,074,262 Peru FTA 202,000 7,777... acquisitions of commercial items or components, when the estimated value equals or exceeds $25,000, but is less...

  14. 78 FR 65214 - Defense Federal Acquisition Regulation Supplement: Only One Offer-Further Implementation (DFARS...

    Science.gov (United States)

    2013-10-31

    ... exclusions. In accordance with FAR 19.805-1, an acquisition offered to the SBA shall be awarded on the basis... certified cost or pricing data is covered in FAR 15.4 and associated clauses in 52.215, OMB clearance 9000... 15.4 and associated clauses in FAR 52.215, and in OMB clearance 9000-013, Cost or Pricing Data...

  15. 77 FR 2679 - Defense Federal Acquisition Regulation Supplement: Order of Application for Modifications

    Science.gov (United States)

    2012-01-19

    ... following methods: [cir] Regulations.gov : http://www.regulations.gov . Submit comments via the Federal e... contract. In order to determine the sequence of modifications to a contract or order, a method for... the numeric order of the modifications to a contract is not the order in which the changes to the...

  16. 76 FR 71922 - Defense Federal Acquisition Regulation Supplement: Separation of Combined Provisions and Clauses...

    Science.gov (United States)

    2011-11-21

    ..., using any of the following methods: [cir] Regulations.gov : http://www.regulations.gov . Submit comments... Training 252.209-7003, Reserve Officer Corps and Military Recruiting on Training Corps and Military Campus. Recruiting on Campus-- Representation. 252.216-7000, Economic Price 252.216-70XX, Economic Price Adjustment...

  17. 76 FR 23505 - Defense Federal Acquisition Regulation Supplement; Accelerate Small Business Payments (DFARS Case...

    Science.gov (United States)

    2011-04-27

    ..., distributive impacts, and equity). Executive Order 13563 emphasizes the importance of quantifying both costs... Regulations System. Therefore, 48 CFR part 232 is amended as follows: PART 232--CONTRACT FINANCING 0 1. The...

  18. 76 FR 21851 - Defense Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Services...

    Science.gov (United States)

    2011-04-19

    ...://regulations.gov , including any personal information provided. To confirm receipt of your comment, please... impacts, and equity). Executive Order 13563 emphasizes the importance of quantifying both costs and... terminated for default regardless of contract value. For Architect and Engineer (A&E) services, past...

  19. 76 FR 52139 - Defense Federal Acquisition Regulation Supplement; Government; Property (DFARS Case 2009-D008)

    Science.gov (United States)

    2011-08-19

    ... responsibility for compliance with export control law and regulations a ``due diligence responsibility.'' DoD... clearance officer suspects data integrity issues; however, 245.602-1(2) has been clarified to specify... that the supplier name and part number be required for all items in Federal condition code A1 being...

  20. 77 FR 38736 - Defense Federal Acquisition Regulation Supplement: New Qualifying Country-Czech Republic (DFARS...

    Science.gov (United States)

    2012-06-29

    ... consistent with national laws, regulations, policies, and international obligations. The agreement does not... Kingdom of Great Britain and Northern Ireland * * * * * 252.225-7012 [Amended] 0 7. Amend section 252.225... Switzerland Turkey United Kingdom of Great Britain and Northern Ireland * * * * * 252.225-7021 [Amended] 0 9...

  1. 77 FR 51957 - Defense Federal Acquisition Regulation Supplement: Clarification of “F” Orders in the Procurement...

    Science.gov (United States)

    2012-08-28

    ... multi-agency contracts, or basic ordering agreements. The proposed text also directs that a... agreements, or blanket purchase agreements. As a result of the proposed rule, new awards under the AbilityOne... Part 204 Government procurement. Manuel Quinones, Editor, Defense Acquisition Regulations System...

  2. 75 FR 59101 - Defense Federal Acquisition Regulation Supplement; DoD Office of the Inspector General Address...

    Science.gov (United States)

    2010-09-27

    ....203-13, Contractor Code of Business Ethics and Conduct. DATES: Effective Date: September 27, 2010. FOR... Acquisition Regulation (FAR) Case 2007-006, ``Contractor Business Ethics Compliance Program and Disclosure... date of December 12, 2008. The contract clause entitled ``Contractor Code of Business Ethics and...

  3. 75 FR 66680 - Defense Federal Acquisition Regulation Supplement; Trade Agreements-New Thresholds (DFARS 2009-D040)

    Science.gov (United States)

    2010-10-29

    ... Trade Organization Government Procurement Agreement and the Free Trade Agreements, as determined by the... of Subjects in 48 CFR Part 225 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition...

  4. 75 FR 18029 - Defense Federal Acquisition Regulation Supplement; Export-Controlled Items (DFARS Case 2004-D010)

    Science.gov (United States)

    2010-04-08

    ... regulations and prescribes a contract clause to address those responsibilities. DATES: Effective Date: April 8... activities and communication between the parties to a potential contract, and to have the resulting contract... Government needs to convey to the universities the information that certain work is export-controlled. DoD...

  5. 75 FR 10567 - Commerce Acquisition Regulation (CAR)

    Science.gov (United States)

    2010-03-08

    ... regulations, Federal acquisition regulations, Government procurement, Government contracts, Procurement, Reporting and recordkeeping requirements. 48 CFR Part 1302 Definitions, Government procurement, Terms. 48 CFR Part 1303 Antitrust, Conflict of interests, Ethical conduct, Government procurement, Reporting and...

  6. 78 FR 35195 - Acquisition Regulations: Export Control

    Science.gov (United States)

    2013-06-12

    ... DEPARTMENT OF ENERGY 48 CFR Parts 925, 952, and 970 RIN 1991-AB99 Acquisition Regulations: Export... Energy (DOE) is proposing to amend the Department of Energy Acquisition Regulation (DEAR) to add export... comments, identified by ``DEAR: Export Control and RIN 1991-AB99,'' by any of the following methods...

  7. 78 FR 45168 - Acquisition Regulations: Export Control

    Science.gov (United States)

    2013-07-26

    ... DEPARTMENT OF ENERGY 48 CFR Parts 925, 952 and 970 RIN 1991-AB99 Acquisition Regulations: Export... (78 FR 35195) to amend the Department of Energy Acquisition Regulation (DEAR) to add export control... ``DEAR: Export Control and RIN 1991-AB99,'' by any of the following methods: Federal eRulemaking Portal...

  8. 48 CFR Appendix - Federal Acquisition Regulation (FAR) Index

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Federal Acquisition Regulation (FAR) Index Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT... (IFMS) Contract clause. FAR Index Federal Acquisition Regulation (FAR) Index Editorial Note: This...

  9. Supplemental knowledge acquisition through external product interface for CLIPS

    Science.gov (United States)

    Saito, Tim; Ebaud, Stephen; Loftin, Bowen R.

    1990-01-01

    Traditionally, the acquisition of knowledge for expert systems consisted of the interview process with the domain or subject matter expert (SME), observation of domain environment, and information gathering and research which constituted a direct form of knowledge acquisition (KA). The knowledge engineer would be responsible for accumulating pertinent information and/or knowledge from the SME(s) for input into the appropriate expert system development tool. The direct KA process may (or may not) have included forms of data or documentation to incorporate from the SME's surroundings. The differentiation between direct KA and supplemental KA (indirect) would be the difference in the use of data. In acquiring supplemental knowledge, the knowledge engineer would access other types of evidence (manuals, documents, data files, spreadsheets, etc.) that would support the reasoning or premises of the SME. When an expert makes a decision in a particular task, one tool that may have been used to justify a recommendation, would have been a spreadsheet total or column figure. Locating specific decision points from that data within the SME's framework would constitute supplemental KA. Data used for a specific purpose in one system or environment would be used as supplemental knowledge for another, specifically a CLIPS project.

  10. Shigella Iron Acquisition Systems and their Regulation.

    Science.gov (United States)

    Wei, Yahan; Murphy, Erin R

    2016-01-01

    Survival of Shigella within the host is strictly dependent on the ability of the pathogen to acquire essential nutrients, such as iron. As an innate immune defense against invading pathogens, the level of bio-available iron within the human host is maintained at exceeding low levels, by sequestration of the element within heme and other host iron-binding compounds. In response to sequestration mediated iron limitation, Shigella produce multiple iron-uptake systems that each function to facilitate the utilization of a specific host-associated source of nutrient iron. As a mechanism to balance the essential need for iron and the toxicity of the element when in excess, the production of bacterial iron acquisition systems is tightly regulated by a variety of molecular mechanisms. This review summarizes the current state of knowledge on the iron-uptake systems produced by Shigella species, their distribution within the genus, and the molecular mechanisms that regulate their production.

  11. 76 FR 68044 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-54; Small Entity Compliance Guide

    Science.gov (United States)

    2011-11-02

    ... Acquisition Circular 2005-54; Small Entity Compliance Guide AGENCY: Department of Defense (DoD), General... Federal Acquisition Circular (FAC) 2005-54, which amend the Federal Acquisition Regulation (FAR... (FAR Case 2009-006) This final rule amends the FAR to implement Executive Order (E.O.) 13494, Economy...

  12. 75 FR 19179 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-41; Small Entity Compliance Guide

    Science.gov (United States)

    2010-04-13

    ... Acquisition Circular 2005-41; Small Entity Compliance Guide AGENCIES: Department of Defense (DoD), General... Federal Acquisition Circular (FAC) 2005-41 which amends the Federal Acquisition Regulation (FAR... projects where the total cost to the Government is $25 million or more in order to promote economy and...

  13. 78 FR 46781 - Federal Acquisition Regulation; Definition of Contingency Operation

    Science.gov (United States)

    2013-08-01

    ... Federal Acquisition Regulation; Definition of Contingency Operation AGENCY: Department of Defense (DoD... the Federal Acquisition Regulation (FAR) to revise the definition of ``contingency operation'' to... ``contingency operation'' at FAR 2.101 in accordance with the statutory change to the definition made by...

  14. Problems and Prospects: Public Health Regulation of Dietary Supplements.

    Science.gov (United States)

    Binns, Colin W; Lee, Mi Kyung; Lee, Andy H

    2018-04-01

    Dietary supplements are a global business worth more than US$100 billion annually. These supplements are taken by up to 50% of adults and perhaps one-third of children in economically advanced economies. Definitions of dietary supplements differ from country to country, and regulation is generally lax and often seems to be directed more toward promoting commerce than protecting public health. Supplements may directly cause toxic reactions or may interact with other supplements or pharmaceuticals. Some supplements are found to have been contaminated with heavy metals, and others do not contain the expected quantities of active ingredients. In general, supplements are not needed except in cases of established deficiencies, and excess of some nutrients can increase cancer rates. There are important public health reasons for taking some supplements, including folate and iodine in pregnancy. This review discusses the public health concerns associated with dietary supplements and suggests directions for further regulation.

  15. 75 FR 14057 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-40; Introduction

    Science.gov (United States)

    2010-03-23

    ... the Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) in..., consider all the information in FAPIIS and PPIRS when making a responsibility determination, and notify the... appropriate for the official's consideration; and Enter a non-responsibility determination into FAPIIS. The...

  16. 75 FR 53127 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-45; Introduction

    Science.gov (United States)

    2010-08-30

    ... summarizes the Federal Acquisition Regulation (FAR) rules agreed to by the Civilian Agency Acquisition... Chambers. Cost or Pricing Data. III American Recovery 2009-008 Davis. and Reinvestment Act of 2009 (the Recovery Act)-- Buy American Requirements for Construction Materials. SUPPLEMENTARY INFORMATION: Summaries...

  17. 76 FR 14572 - Federal Acquisition Regulation; Technical Amendments

    Science.gov (United States)

    2011-03-16

    ... Acquisition Regulations. List of Subjects in 48 CFR Parts 18, 19, and 52 Government procurement. Dated: March... in paragraph (b) by removing ``http:// www.whitehouse.gov/omb/procurement/guides/emergency_acquisitions_ guide.pdf'' and adding ``http://www.whitehouse.gov/sites/default/files/ omb/assets/procurement...

  18. 75 FR 14496 - Commerce Acquisition Regulation (CAR); Correction

    Science.gov (United States)

    2010-03-26

    ... DEPARTMENT OF COMMERCE 48 CFR Part 1352 [Document Number: 080730954-0129-03] RIN 0605-AA26 Commerce Acquisition Regulation (CAR); Correction AGENCY: Department of Commerce (DOC). ACTION: Final rule; correction. SUMMARY: We, the Department of Commerce, issue a final rule to bring the Commerce Acquisition...

  19. 78 FR 46783 - Federal Acquisition Regulation; Documenting Contractor Performance

    Science.gov (United States)

    2013-08-01

    ..., Sequence 1] RIN 9000-AM09 Federal Acquisition Regulation; Documenting Contractor Performance AGENCY... the Contractor Performance Assessment Reporting System (CPARS), the single Governmentwide past... Procurement Policy (OFPP) memorandum entitled ``Improving the Use of Contractor Performance Information...

  20. 76 FR 37704 - Federal Acquisition Regulation; Documenting Contractor Performance

    Science.gov (United States)

    2011-06-28

    ... Federal Acquisition Regulation; Documenting Contractor Performance AGENCY: Department of Defense (DoD..., and to require all past performance information be entered into the Contractor Performance Assessment... Contractor Performance Information. These changes provide Governmentwide standardized evaluation factors and...

  1. 78 FR 13765 - Federal Acquisition Regulation; Definition of Contingency Operation

    Science.gov (United States)

    2013-02-28

    ... Federal Acquisition Regulation; Definition of Contingency Operation AGENCY: Department of Defense (DoD... Regulation (FAR) to revise the definition of ``contingency operation'' to address the statutory change to the... ``contingency operation'' at FAR 2.101 in accordance with the statutory change to the definition made by...

  2. 78 FR 29247 - Contractor Legal Management Requirements; Acquisition Regulations; Correction

    Science.gov (United States)

    2013-05-20

    ... DEPARTMENT OF ENERGY 48 CFR Part 952 RIN 1990-AA37 Contractor Legal Management Requirements; Acquisition Regulations; Correction AGENCY: Department of Energy. ACTION: Final rule; correction. SUMMARY: The... (78 FR 25795). In this document, DOE revised existing regulations covering contractor legal management...

  3. Training and Doctrine Command Acquisition Management and Oversight Supplement

    Science.gov (United States)

    2011-06-01

    the foundation for all future procurement decisions. Chapter 4 of TR 5-14 requires the RA to gain approval and certification by the designated...CLM013-Work-Breakdown Structure CLM031-Improved Statement of Work ACQ265-Mission Focused Services Acquisition Army eLearning https...will be returned to acceptable levels, and how recurrence of the cause will be prevented in the future . 53 7.3. Performance Requirements Summary

  4. Development of a Naval Supply Systems Command Acquisition Supplement - A Business Practice Improvement

    Science.gov (United States)

    2015-09-01

    Applicable to NAVSUP NFCS (after NLL, 2015) ...................21 Table 3. DON SAP Policy Letters (after NLL, 2015...and Acquisition Policy ERP Enterprise Resource Planning FAR Federal Acquisition Regulation FLC Fleet Logistic Center GLS Global Logistics...DON SAP Policy Letters (after NLL, 2015) Policy Letter # Subject Date Issued Current? Y/N Comments SA12- 03R1 NAVSUP ENTERPRISE POLICY FOR

  5. 75 FR 60258 - Federal Acquisition Regulation; Termination for Default Reporting

    Science.gov (United States)

    2010-09-29

    ..., Sequence 1] RIN 9000-AL45 Federal Acquisition Regulation; Termination for Default Reporting AGENCIES... terminations for cause or default and defective cost or pricing data, into the Past Performance Information... defective cost or pricing data and terminations for cause or default into the FAPIIS module of the PPIRS...

  6. 76 FR 39242 - Federal Acquisition Regulation; TINA Interest Calculations

    Science.gov (United States)

    2011-07-05

    ... pricing data. This rule replaces the term ``simple interest'' as the requirement for calculating interest...-AL73 Federal Acquisition Regulation; TINA Interest Calculations AGENCIES: Department of Defense (DoD... interest calculations be applied to Government overpayments as a result of defective cost or pricing data...

  7. 77 FR 29983 - Federal Acquisition Regulation; Information Collection; Subcontract Consent

    Science.gov (United States)

    2012-05-21

    ... performance of functions of the Federal Acquisition Regulation (FAR), and whether it will have practical... The objective of consent to subcontract, as discussed in FAR Part 44, is to evaluate the efficiency and effectiveness with which the contractor spends Government funds, and complies with Government...

  8. 77 FR 12930 - Federal Acquisition Regulation: Socioeconomic Program Parity

    Science.gov (United States)

    2012-03-02

    ... (SDVOSB) Program, or the Women-Owned Small Business (WOSB) Program. DATES: Effective Date: April 2, 2012...) Program (see subpart 19.14); or (iv) Women-Owned Small Business (WOSB) Program (see subpart 19.15). (3... amending the Federal Acquisition Regulation (FAR) to implement a section of the Small Business Jobs Act of...

  9. 77 FR 189 - Federal Acquisition Regulation; Brand-Name Specifications

    Science.gov (United States)

    2012-01-03

    ... 2006-0020, Sequence 26] RIN 9000-AK55 Federal Acquisition Regulation; Brand-Name Specifications... Management and Budget memoranda on brand-name specifications. DATES: Effective Date: February 2, 2012. FOR... brand- name specifications. Eight respondents submitted 32 comments in response to the interim rule. The...

  10. Should states and local governments regulate dietary supplements?

    Science.gov (United States)

    Starr, Ranjani

    2016-01-01

    Federal regulation of dietary supplements in the United States is governed by the Dietary Supplement Health and Education Act of 1994. The law has been criticized as weak and ineffective. Alarming research has emerged demonstrating that supplements may be mislabelled, contaminated, adulterated with dangerous or unknown compounds, or sold at toxic doses. As a result, the health community has raised concerns about the safety and quality of dietary supplements. Increased federal oversight is an important avenue for improving supplement safety; however, states and local governments may also pursue strategies to strengthen the overall regulatory control of dietary supplements. States and local governments have substantial experience in regulating other products that pose a risk to public health, such as tobacco. Additionally, much has been learned about the tactics the tobacco industry has employed to protect its interests. Lessons learned may be applied to new regulatory efforts aimed at improving the safety of dietary supplements at the state and local levels. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  11. 75 FR 60261 - Federal Acquisition Regulation; Award-Fee Language Revision

    Science.gov (United States)

    2010-09-29

    ...-AL42 Federal Acquisition Regulation; Award-Fee Language Revision AGENCIES: Department of Defense (DoD...: Final rule. SUMMARY: The Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) have adopted as final, with changes, the interim rule amending the Federal Acquisition...

  12. 76 FR 8989 - Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References

    Science.gov (United States)

    2011-02-16

    ... Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References AGENCIES... Acquisition Regulation (FAR) to update references to authoritative accounting standards owing to the Financial... Accounting Principles (GAAP) (``Codification of GAAP''). DATES: Interested parties should submit written...

  13. 76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2011-05-11

    ...; facsimile 703-602-0350. SUPPLEMENTARY INFORMATION: This final rule amends DFARS by adding language at 225... considerations when supporting contingency operations. The rule also adds language and a new subpart at 225.78... the geographic combatant commander, which may include support such as military exercises/training...

  14. 77 FR 76936 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2012-12-31

    ...; List of Subjects in 48 CFR Parts 201, 203, 204, 215, 219, 245, and 252 Government procurement. Manuel... clause 52.203-13, Contractor Code of Business Ethics and Conduct, is the DoD Office of Inspector General...

  15. 78 FR 13543 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2013-02-28

    ..., 204, 215, 225, 227, 242, 245 and 252 Government procurement. Manuel Quinones, Editor, Defense...) shall be conducted only when-- (i) A contractor has $50 million of qualifying sales to the Government... circumstance(s) may result in a material impact on Government contract costs: (1) Information or data reveals a...

  16. 76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Technical Amendment

    Science.gov (United States)

    2011-05-11

    ... procurement programs, it must provide written notice of the determination to the GSA Suspension and Debarment Official. List of Subjects in 48 CFR Part 209 Government procurement. Ynette R. Shelkin, Editor, Defense... suspended from procurement programs, it must provide written notice of the determination to the General...

  17. 76 FR 76318 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2011-12-07

    ... Defense Business Transformation Agency Contracting Office. PART 204--ADMINISTRATIVE MATTERS 204.402...) * * * (iii) For special notices for small business events, follow the procedures at PGI 205.207(d)(ii). PART... Economy Act order. PART 219--SMALL BUSINESS PROGRAMS 0 22. Section 219.202-1 is added to read as follows...

  18. 77 FR 31536 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2012-05-29

    ... interim rule amends DFARS part 252 to implement the United States- Colombia Trade Promotion Agreement Implementation Act (Pub. L. 112-42) (19 U.S.C. 3805 note) by adding Colombia to the definition of ``Free Trade...--SOLICITATION PROVISIONS AND CONTRACT CLAUSES 0 1. The authority citation for 48 CFR part 252 continues to read...

  19. 77 FR 52253 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

    Science.gov (United States)

    2012-08-29

    ...-7017(a) to add Armenia to the definition of ``Designated country'', which was inadvertently omitted... other limitations on their use. * * * * * PART 230--COST ACCOUNTING STANDARDS ADMINISTRATION 0 7. The...) definition of ``Designated country'' at paragraph (i) by adding the country of Armenia within the parentheses...

  20. 76 FR 16043 - Agency Information Collection (Department of Veterans Affairs Acquisition Regulations Clause 852...

    Science.gov (United States)

    2011-03-22

    ... contracts for the acquisition of non-personal health care services. It requires the bidder/offeror prior to... Acquisition Regulation Clause 52.207-3, Right of First Refusal of Employment. An agency may not conduct or...

  1. 76 FR 46206 - NASA Implementation of Federal Acquisition Regulation (FAR) Award Fee Language Revision

    Science.gov (United States)

    2011-08-02

    ... of Federal Acquisition Regulation (FAR) Award Fee Language Revision AGENCY: National Aeronautics and... Acquisition Circular (FAC) 2005-46. DATES: Effective Date: August 2, 2011. FOR FURTHER INFORMATION CONTACT... on February 8, 2011 (76 FR 6696) implementing Federal Acquisition Circular (FAC) 2005-46 which...

  2. 76 FR 6696 - NASA Implementation of Federal Acquisition Regulation (FAR) Award Fee Language Revision

    Science.gov (United States)

    2011-02-08

    ... of Federal Acquisition Regulation (FAR) Award Fee Language Revision AGENCY: National Aeronautics and... (NFS) to implement the FAR Award Fee revision issued in Federal Acquisition Circular (FAC) 2005-46.... Background Federal Acquisition Circular (FAC) 2005-46 significantly revised FAR Parts 16.305, 16.401, and 16...

  3. 77 FR 6985 - General Services Administration Acquisition Regulation; Reinstatement of Coverage Pertaining to...

    Science.gov (United States)

    2012-02-10

    ... Acquisition Regulation; Reinstatement of Coverage Pertaining to Final Payment Under Construction and Building... Administration Acquisition Regulation (GSAR) to restore guidance on the release of claims after completion of construction and building service contracts to ensure contractors are paid in accordance with their contract...

  4. 76 FR 14543 - Federal Acquisition Regulation; Proper Use and Management of Cost-Reimbursement Contracts

    Science.gov (United States)

    2011-03-16

    ..., Sequence 1] RIN 9000-AL78 Federal Acquisition Regulation; Proper Use and Management of Cost-Reimbursement... other than firm-fixed-price contracts (e.g., cost-reimbursement, time-and-material, and labor-hour...-reimbursement contracts and identifies the following three areas that the Defense Acquisition Regulation Council...

  5. 77 FR 51496 - Federal Acquisition Regulation; Basic Safeguarding of Contractor Information Systems

    Science.gov (United States)

    2012-08-24

    ... Federal Acquisition Regulation; Basic Safeguarding of Contractor Information Systems AGENCY: Department of... Acquisition Regulation (FAR) to add a new subpart and contract clause for the basic safeguarding of contractor... information) that will be resident on or transiting through contractor information systems. DATES: Interested...

  6. 77 FR 27550 - Federal Acquisition Regulation; Revision of Cost Accounting Standards Threshold

    Science.gov (United States)

    2012-05-10

    ...] RIN 9000-AM25 Federal Acquisition Regulation; Revision of Cost Accounting Standards Threshold AGENCY... Federal Acquisition Regulation (FAR) to revise the threshold for applicability of cost accounting standards in order to implement a recent rule of the Cost Accounting Standards Board and statutory...

  7. 76 FR 74755 - Office of Procurement and Property Management; Agriculture Acquisition Regulation, Labor Law...

    Science.gov (United States)

    2011-12-01

    ... Management; Agriculture Acquisition Regulation, Labor Law Violations AGENCY: Office of Procurement and... Agriculture Acquisition Regulation (the ``AGAR'') to add a new clause at subpart 422.70 entitled ``Labor Law... respects and follows the policies and laws regarding worker labor protections particularly as they [[Page...

  8. 77 FR 5750 - Office of Procurement and Property Management; Agriculture Acquisition Regulation, Labor Law...

    Science.gov (United States)

    2012-02-06

    ... Management; Agriculture Acquisition Regulation, Labor Law Violations; Withdrawal AGENCY: Office of... Agriculture Acquisition Regulation at subpart 422.70 entitled ``Labor Law Violations'' that would have a contractor certify upon accepting a contract that it is in compliance with all applicable labor laws and that...

  9. 76 FR 74722 - Office of Procurement and Property Management; Agriculture Acquisition Regulation, Labor Law...

    Science.gov (United States)

    2011-12-01

    ... Management; Agriculture Acquisition Regulation, Labor Law Violations AGENCY: Office of Procurement and... Acquisition Regulation (the ``AGAR'') to add a new clause at subpart 422.70 entitled ``Labor Law Violations... objectives, this proposed rule adds a subpart and clause entitled Labor Law Violations to the Agriculture...

  10. 78 FR 46795 - Federal Acquisition Regulation; Technical Amendments

    Science.gov (United States)

    2013-08-01

    ... changes to the FAR. List of Subject in 48 CFR Parts 2, 22, and 52 Government procurement. Dated: July 26, 2013. William Clark, Acting Director, Office of Government-wide Acquisition Policy, Office of Acquisition Policy, Office of Government-wide Policy. Therefore, DoD, GSA, and NASA amend 48 CFR parts 2, 22...

  11. 76 FR 21810 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items (DFARS Case...

    Science.gov (United States)

    2011-04-19

    ... subpart 15.4 currently provides the contracting officer with pricing policy and guidance regarding... from pricing determinations. DoD Response: There is currently sufficient coverage in the FAR to assist contracting officers with making separate commercial and pricing determinations. Contracting officers have the...

  12. 77 FR 38734 - Defense Federal Acquisition Regulation Supplement; Acquisition of Tents and Other Temporary...

    Science.gov (United States)

    2012-06-29

    ....gov , including any personal information provided. To confirm receipt of your comment(s), please check... Fiscal Year 2012 (Pub. L. 112- 81). Section 368 requires award of contracts that provide the best value..., public health and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance...

  13. 75 FR 18035 - Defense Federal Acquisition Regulation Supplement; Acquisitions in Support of Operations in Iraq...

    Science.gov (United States)

    2010-04-08

    ... for billboards for a total of $73 million. DoD has a relatively small role in the overall U.S. economy... significantly the intended boost to the Iraqi and Afghani industrial base. 2. Concern for the Industrial Base of...

  14. 77 FR 2653 - Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military...

    Science.gov (United States)

    2012-01-19

    ... entity referred to in the interim rule is, in essence, the legal entity that signs the contract with the... contractors as defined within the rule and section 866 of the National Defense Authorization Act for Fiscal...

  15. 75 FR 1567 - Defense Federal Acquisition Regulation Supplement; Foreign Participation in Acquisitions in...

    Science.gov (United States)

    2010-01-12

    ..., ammunition, or war materials) from the SC/CASA states to support operations in Afghanistan. The end of the... in Support of Operations in Afghanistan AGENCY: Department of Defense (DoD). ACTION: Proposed rule...

  16. 75 FR 832 - Defense Federal Acquisition Regulation Supplement; Foreign Participation in Acquisitions in...

    Science.gov (United States)

    2010-01-06

    ..., ammunition, or war materials) from the SC/CASA states to support operations in Afghanistan. DATES: Comment... in Afghanistan (DFARS Case 2009-D012) AGENCY: Department of Defense (DoD). ACTION: Proposed rule with... Afghanistan. This waiver applies to offers of products and services from the following nine South Caucasus...

  17. 76 FR 38048 - Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military...

    Science.gov (United States)

    2011-06-29

    ... under the cost accounting standards prescribed pursuant to section 26 of the Office of Federal... conflict with this rule. There are no known significant alternatives to the rule. Accordingly, DoD does not... pricing data; (2) Exempt from the cost accounting standards under section 26 of the Office of Procurement...

  18. 78 FR 73472 - Defense Federal Acquisition Regulation Supplement: Application of Certain Clauses to Acquisitions...

    Science.gov (United States)

    2013-12-06

    .... 13563 emphasizes the importance of quantifying both costs and benefits, of reducing costs, of... WorkFlow Payment Instructions, as prescribed in 232.7004(b). * * * * * PART 232--CONTRACT FINANCING 0 4...

  19. 75 FR 51416 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items

    Science.gov (United States)

    2010-08-20

    ... provided clarification regarding situations under which the procurement of a major weapon system..., et seq. List of Subjects in 48 CFR Parts 202, 212, and 234 Government procurement. Ynette R. Shelkin...: DoD is adopting as final, without change, the interim rule that amended the Defense Federal...

  20. 75 FR 8272 - Defense Federal Acquisition Regulation Supplement; Acquisition Strategies To Ensure Competition...

    Science.gov (United States)

    2010-02-24

    ... limited to, cost-effective measures intended to achieve the following: (i) Competitive prototyping. (ii... subsystems. (v) Use of modular, open architectures to enable competition for upgrades. (vi) Use of build-to...

  1. 78 FR 59854 - Defense Federal Acquisition Regulation Supplement: Acquisitions in Support of Operations in...

    Science.gov (United States)

    2013-09-30

    ...)(xxvi); 0 b. Removing paragraph (f)(xxvii) and redesignating paragraphs (f)(xxviii) through (xxxii) as.... Adding a new paragraph (f)(xxxii); and 0 e. Revising paragraphs (f)(xxxiv) and (xxxv). The revisions and... National Defense Authorization Act for Fiscal Year 2008 (Pub. L. 110-181). * * * * * (xxxii) Use the clause...

  2. Transcriptional regulator-mediated activation of adaptation genes triggers CRISPR de novo spacer acquisition

    DEFF Research Database (Denmark)

    Liu, Tao; Li, Yingjun; Wang, Xiaodi

    2015-01-01

    Acquisition of de novo spacer sequences confers CRISPR-Cas with a memory to defend against invading genetic elements. However, the mechanism of regulation of CRISPR spacer acquisition remains unknown. Here we examine the transcriptional regulation of the conserved spacer acquisition genes in Type I......, it was demonstrated that the transcription level of csa1, cas1, cas2 and cas4 was significantly enhanced in a csa3a-overexpression strain and, moreover, the Csa1 and Cas1 protein levels were increased in this strain. Furthermore, we demonstrated the hyperactive uptake of unique spacers within both CRISPR loci...... in the presence of the csa3a overexpression vector. The spacer acquisition process is dependent on the CCN PAM sequence and protospacer selection is random and non-directional. These results suggested a regulation mechanism of CRISPR spacer acquisition where a single transcriptional regulator senses the presence...

  3. 78 FR 53761 - Federal Acquisition Regulation; Submission for OMB Review; Commercial Item Acquisitions

    Science.gov (United States)

    2013-08-30

    ... provided. FOR FURTHER INFORMATION CONTACT: Mr. Michael O. Jackson, Procurement Analyst, Office of Governmentwide Acquisition Policy, GSA (202) 208- 4949 or email at michaelo.jackson@gsa.gov . SUPPLEMENTARY...

  4. 78 FR 18349 - Federal Acquisition Regulation; Information Collection; Commercial Item Acquisitions

    Science.gov (United States)

    2013-03-26

    ... information provided. FOR FURTHER INFORMATION CONTACT: Mr. Michael O. Jackson, Procurement Analyst, Office of Governmentwide Acquisition Policy, GSA (202) 208- 4949 or email at michaelo.jackson@gsa.gov . SUPPLEMENTARY...

  5. 77 FR 13956 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-57; Small Entity Compliance Guide

    Science.gov (United States)

    2012-03-07

    ... Trade Organization Government Procurement Agreement (WTO GPA). This Free Trade Agreement now covers acquisition of supplies and services between $100,000 and the current WTO GPA threshold of $202,000. This...

  6. 77 FR 43083 - Federal Acquisition Regulation; Information Collection; Advance Payments

    Science.gov (United States)

    2012-07-23

    ...; Information Collection; Advance Payments AGENCIES: Department of Defense (DOD), General Services... requirement concerning advance payments. Public comments are particularly invited on: Whether this collection of information is necessary for the proper performance of functions of the Federal Acquisition...

  7. 76 FR 31415 - Federal Acquisition Regulation; Buy American Exemption for Commercial Information Technology...

    Science.gov (United States)

    2011-05-31

    ... 9000-AL62 Federal Acquisition Regulation; Buy American Exemption for Commercial Information Technology... from the Buy American Act for acquisition of information technology that is a commercial item. DATES: Effective Date: May 31, 2011. FOR FURTHER INFORMATION CONTACT: Ms. Cecelia L. Davis, Procurement Analyst, at...

  8. 77 FR 12913 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Science.gov (United States)

    2012-03-02

    ... 2010-015; Item I; Docket 2010-0015, Sequence 1] RIN 9000-AL97 Federal Acquisition Regulation; Women... Regulation (FAR) to implement the Small Business Administration's regulations establishing the Women-Owned Small Business (WOSB) Program. This rule authorizes the restriction of competition for Federal contracts...

  9. 76 FR 34886 - General Services Administration Acquisition Regulation; Implementation of Information Technology...

    Science.gov (United States)

    2011-06-15

    ... Acquisition Regulation; Implementation of Information Technology Security Provision AGENCY: Office of... information technology (IT) supplies, services and systems with security requirements. DATES: Effective Date... effective date that include information technology (IT) supplies, services and systems with security...

  10. 77 FR 749 - General Services Administration Acquisition Regulation; Implementation of Information Technology...

    Science.gov (United States)

    2012-01-06

    ... Acquisition Regulation; Implementation of Information Technology Security Provision AGENCY: Office of... orders that include information technology (IT) supplies, services and systems. DATES: Effective Date... 6, 2012 that include information technology (IT) supplies, services and systems with security...

  11. 75 FR 4565 - General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial...

    Science.gov (United States)

    2010-01-28

    ... Acquisition Regulation; Submission for OMB Review; Industrial Funding Fee and Sales Reporting AGENCY... Management and Budget (OMB) a request to review and approve a reinstatement of a previously approved information collection requirement regarding industrial [[Page 4566

  12. 77 FR 202 - Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting References

    Science.gov (United States)

    2012-01-03

    ... 9000-AM00 Federal Acquisition Regulation; Updated Financial Accounting Standards Board Accounting... accounting standards owing to the Financial Accounting Standards Board's Accounting Standards Codification of Generally Accepted Accounting Principles. DATES: Effective Date: February 2, 2012. FOR FURTHER INFORMATION...

  13. 77 FR 15370 - General Services Administration Acquisition Regulation; Information Collection; Price Reductions...

    Science.gov (United States)

    2012-03-15

    ... Services Administration Acquisition Regulation; Information Collection; Price Reductions Clause; Extension... notice of request for comments regarding OMB Control No. 3090-0235, Price Reductions Clause, published in... 16, 2012. ADDRESSES: Submit comments identified by Information Collection 3090- 0235, Price...

  14. 76 FR 2761 - Proposed Information Collection (Department of Veterans Affairs Acquisition Regulations Clause...

    Science.gov (United States)

    2011-01-14

    ... contracts for the acquisition of non-personal health care services. It requires the bidder/offeror prior to... Regulation clause 52.207-3, Right of First Refusal of Employment. Affected Public: Business or other for...

  15. 76 FR 73564 - Federal Acquisition Regulation; Updates to Contract Reporting and Central Contractor Registration

    Science.gov (United States)

    2011-11-29

    ... Federal Acquisition Regulation; Updates to Contract Reporting and Central Contractor Registration AGENCIES... Procurement Data System (FPDS). Additionally, changes are proposed for the clauses requiring contractor registration in the Central Contractor Registration (CCR) database and DUNS number reporting. DATES: Interested...

  16. 78 FR 46779 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-69; Introduction

    Science.gov (United States)

    2013-08-01

    ... recommendations from the Government Accountability Office Report GAO-09-374, Better Performance Information Needed... requirements on small business. Item IV--Repeal of Sunset for Certain Protests of Task and Delivery Order... treated as designated countries. In acquisitions that are covered by the World Trade Organization...

  17. 77 FR 19975 - VA Acquisition Regulation: Simplified Acquisition Procedures for Health-Care Resources (Section...

    Science.gov (United States)

    2012-04-03

    ... to which technology, economic conditions, or other factors have changed in the area affected by the... comments on factors described in the Supplementary Information. DATES: Comments must be received by VA on... (003A2A), Office of Acquisition, Logistics and Construction, Department of Veterans Affairs, 810 Vermont...

  18. 77 FR 56737 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-61; Introduction

    Science.gov (United States)

    2012-09-13

    ... Trade Organization Government Procurement Agreement (WTO GPA). The Korea Free Trade Agreement now covers acquisition of supplies and services between $100,000 and the current WTO GPA threshold of $202,000. This...'', which is no longer in existence. There is no impact to the Government or small business because this...

  19. 77 FR 56744 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-61; Small Entity Compliance Guide

    Science.gov (United States)

    2012-09-13

    ... Trade Organization Government Procurement Agreement (WTO GPA). The Korea Free Trade Agreement now covers acquisition of supplies and services between $100,000 and the current WTO GPA threshold of $202,000. This...'', which is no longer in existence. There is no impact to the Government or small business because this...

  20. 77 FR 13951 - Federal Acquisition Regulation; Federal Acquisition Circular 2005-57; Introduction

    Science.gov (United States)

    2012-03-07

    ... Trade Organization Government Procurement Agreement (WTO GPA). This Free Trade Agreement now covers acquisition of supplies and services between $100,000 and the current WTO GPA threshold of $202,000. This... effective March 15, 2012. Dated: March 1, 2012. Richard Ginman, Director, Defense Procurement and...

  1. 75 FR 21508 - Health and Human Services Acquisition Regulation; Corrections

    Science.gov (United States)

    2010-04-26

    ..., Federal appropriations law, and green purchasing training requirements, including completion of refresher... law, and green purchasing training requirements, including completion of refresher training. If the... defined in FAR 17.103, is limited to individual acquisitions where the full estimated cancellation ceiling...

  2. 76 FR 12795 - Department of Education Acquisition Regulation

    Science.gov (United States)

    2011-03-08

    ... 3402 Definitions of words and terms 3403 Improper business practices and personal conflicts of interest... commercial items SUBCHAPTER C--CONTRACTING METHODS AND CONTRACT TYPES 3413 Simplified acquisition procedures 3414 Sealed bidding 3415 Contracting by negotiation 3416 Types of contracts 3417 Special contracting...

  3. 77 FR 204 - Federal Acquisition Regulation; Technical Amendments

    Science.gov (United States)

    2012-01-03

    ... Parts 4, 8, 15, 19, 22, 23, 28, 42, and 52 Government procurement. Dated: December 21, 2011. Laura... paragraph (a)(2) ``http:// www.sba.gov/GC/pcr.html'' and adding ``http://www.sba.gov/content/ procurement-center-representatives'' in its place. PART 22--APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS 22...

  4. 76 FR 42056 - Department of the Treasury Acquisition Regulation

    Science.gov (United States)

    2011-07-18

    ... entities. The program is designed for mentoring firms to provide developmental assistance to prot[eacute]g.... Thomas A. Sharpe, Jr., Senior Procurement Executive, Office of the Procurement Executive. Accordingly.... For acquisitions made from non- appropriated funds, the Senior Procurement Executive will determine...

  5. 78 FR 70481 - Federal Acquisition Regulation; Technical Amendments

    Science.gov (United States)

    2013-11-25

    ... changes to the FAR. List of Subject in 48 CFR Parts 31 and 52 Government procurement. Dated: November 18, 2013. William Clark, Acting Director, Office of Government-Wide Acquisition Policy, Office of... procedures of FAR Part 25. For line items covered by the WTO GPA, the Government will evaluate offers of U.S...

  6. Regulating the South African sport supplement industry: 'Whey ...

    African Journals Online (AJOL)

    immune improvement claims, the exact benefits of sport supplements have not been ... Among those that ranked highest were Dis-Chem's house brand,. Biogen ... the establishment of the SA Health Products Regulatory Authority. (SAHPRA) ...

  7. Leucine supplementation protects from insulin resistance by regulating adiposity levels.

    Directory of Open Access Journals (Sweden)

    Elke Binder

    Full Text Available BACKGROUND: Leucine supplementation might have therapeutic potential in preventing diet-induced obesity and improving insulin sensitivity. However, the underlying mechanisms are at present unclear. Additionally, it is unclear whether leucine supplementation might be equally efficacious once obesity has developed. METHODOLOGY/PRINCIPAL FINDINGS: Male C57BL/6J mice were fed chow or a high-fat diet (HFD, supplemented or not with leucine for 17 weeks. Another group of HFD-fed mice (HFD-pairfat group was food restricted in order to reach an adiposity level comparable to that of HFD-Leu mice. Finally, a third group of mice was exposed to HFD for 12 weeks before being chronically supplemented with leucine. Leucine supplementation in HFD-fed mice decreased body weight and fat mass by increasing energy expenditure, fatty acid oxidation and locomotor activity in vivo. The decreased adiposity in HFD-Leu mice was associated with increased expression of uncoupling protein 3 (UCP-3 in the brown adipose tissue, better insulin sensitivity, increased intestinal gluconeogenesis and preservation of islets of Langerhans histomorphology and function. HFD-pairfat mice had a comparable improvement in insulin sensitivity, without changes in islets physiology or intestinal gluconeogenesis. Remarkably, both HFD-Leu and HFD-pairfat mice had decreased hepatic lipid content, which likely helped improve insulin sensitivity. In contrast, when leucine was supplemented to already obese animals, no changes in body weight, body composition or glucose metabolism were observed. CONCLUSIONS/SIGNIFICANCE: These findings suggest that leucine improves insulin sensitivity in HFD-fed mice by primarily decreasing adiposity, rather than directly acting on peripheral target organs. However, beneficial effects of leucine on intestinal gluconeogenesis and islets of Langerhans's physiology might help prevent type 2 diabetes development. Differently, metabolic benefit of leucine supplementation

  8. 76 FR 50714 - Federal Acquisition Regulation; Documenting Contractor Performance; Correction

    Science.gov (United States)

    2011-08-16

    ... Regulation; Documenting Contractor Performance; Correction AGENCY: Department of Defense (DoD), General... August 9, 2011, regarding the proposed rule for Documenting Contractor Performance. DATES: The comment...

  9. 77 FR 67366 - Federal Acquisition Regulation; Information Collection; Travel Costs

    Science.gov (United States)

    2012-11-09

    ...; Information Collection; Travel Costs AGENCY: Department of Defense (DOD), General Services Administration (GSA... requirement concerning Travel Costs. Public comments are particularly invited on: Whether this collection of...- 0088, Travel Costs by any of the following methods: Regulations.gov : http://www.regulations.gov...

  10. 77 FR 12754 - Contractor Legal Management Requirements; Acquisition Regulations

    Science.gov (United States)

    2012-03-02

    ... DEPARTMENT OF ENERGY 10 CFR Part 719 48 Parts 931, 952 and 970 RIN 1990-AA37 Contractor Legal... rulemaking (NOPR) to revise existing regulations covering contractor legal management requirements and make... relating to the DOE notice of proposed rulemaking to revise existing regulations covering contractor legal...

  11. 78 FR 2229 - Health and Human Services Acquisition Regulation

    Science.gov (United States)

    2013-01-10

    ... information (regardless of the form or method of the recording) of a scientific or technical nature (including... (HHSAR)--to add two clauses, ``Patent Rights-- Exceptional Circumstances'' and ``Rights in Data....227-11 and 352.227-14'' by any of the following methods: Regulations.gov : http://www.regulations.gov...

  12. Review: Efficacy of alginate supplementation in relation to appetite regulation and metabolic risk factors

    DEFF Research Database (Denmark)

    Jensen, Morten Georg; Pedersen, C; Kristensen, Mette Bredal

    2013-01-01

    This review provides a critical update on human and animal studies investigating the effect of alginate supplementation on appetite regulation, glycaemic and insulinemic responses, and lipid metabolism with discussion of the evidence on potential mechanisms, efficacy and tolerability. Dependent...

  13. 77 FR 12933 - Federal Acquisition Regulation: Trade Agreements Thresholds

    Science.gov (United States)

    2012-03-02

    ... $202,000 $202,000 $7,777,000 FTAs: Australia FTA 77,494 77,494 7,777,000 Bahrain FTA 202,000 202,000 10...: --Canada 25,000 77,494 10,074,262 --Mexico 77,494 77,494 10,074,262 Oman FTA 202,000 202,000 10,074,262...,000'' and adding ``$202,000'' in its place. PART 25--FOREIGN ACQUISITION 25.202 [Amended] 0 3. Amend...

  14. 78 FR 80379 - Federal Acquisition Regulation; Trade Agreements Thresholds

    Science.gov (United States)

    2013-12-31

    ... $204,000 $7,864,000 FTAs: Australia FTA 79,507 79,507 7,864,000 Bahrain FTA 204,000 204,000 10,335,931...,000 7,864,000 Morocco FTA 204,000 204,000 7,864,000 NAFTA: --Canada 25,000 79,507 10,335,931 --Mexico... adding ``$204,000'' in its place. PART 25--FOREIGN ACQUISITION 25.202 [Amended] 0 5. Amend section 25.202...

  15. 78 FR 41331 - Federal Acquisition Regulation; Publicizing Contract Actions; Contracting by Negotiation

    Science.gov (United States)

    2013-07-10

    ... DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Parts 5 and 15 Federal Acquisition Regulation; Publicizing Contract Actions; Contracting by Negotiation CFR Correction In Title 48 of the Code of Federal Regulations, Chapter 1 (Parts 1 to 51), revised as of October 1, 2012, on page 115, in...

  16. 76 FR 14570 - Federal Acquisition Regulation; Disclosure and Consistency of Cost Accounting Practices for...

    Science.gov (United States)

    2011-03-16

    ...] RIN 9000-AL58 Federal Acquisition Regulation; Disclosure and Consistency of Cost Accounting Practices... Regulation (FAR) to align it with a Cost Accounting Standards (CAS) Board clause, Disclosure and Consistency... the use of the clause, Disclosure and Consistency of Cost Accounting Practices--Foreign Concerns, in...

  17. 77 FR 3636 - Federal Acquisition Regulation; Brand-Name Specifications; Correction

    Science.gov (United States)

    2012-01-25

    ... 26] RIN 9000-AK55 Federal Acquisition Regulation; Brand-Name Specifications; Correction AGENCY... Regulation (FAR) to implement the Office of Management and Budget memoranda on brand-name specifications, FAR Case 2005-037, Brand-Name Specifications, which published in the Federal Register at 77 FR 189 on...

  18. 77 FR 9659 - General Services Administration Acquisition Regulation; Information Collection; GSA Mentor...

    Science.gov (United States)

    2012-02-17

    ... Services Administration Acquisition Regulation; Information Collection; GSA Mentor-Prot[eacute]g[eacute... collection concerning the GSA Mentor-Prot[eacute]g[eacute] Program, General Service Administration...- 0286, GSA Mentor-Prot[eacute]g[eacute] Program by any of the following methods: Regulations.gov : http...

  19. 77 FR 31016 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Mentor...

    Science.gov (United States)

    2012-05-24

    ... Services Administration Acquisition Regulation; Submission for OMB Review; GSA Mentor-Prot[eacute]g[eacute... collection concerning the GSA Mentor-Prot[eacute]g[eacute] Program, General Service Administration... Collection 3090- 0286, GSA Mentor-Prot[eacute]g[eacute] Program by any of the following methods: Regulations...

  20. 76 FR 7522 - Federal Acquisition Regulation; Enhancing Contract Transparency

    Science.gov (United States)

    2011-02-10

    ... transparency while retaining the protection of information that should be considered in the contracting process... the need for transparency in Government contracting information and believe these recommendations... Regulation; Enhancing Contract Transparency AGENCY: Department of Defense (DoD), General Services...

  1. The history of efforts to regulate dietary supplements in the USA.

    Science.gov (United States)

    Swann, John P

    2016-01-01

    This review examines the emergence of dietary supplements and how the Food and Drug Administration (FDA) attempted to regulate these, beginning with the arrival of vitamins and how these were managed under the 1906 Food and Drugs Act, and ending with the seismic influence of the 1994 Dietary Supplement Health and Education Act (DSHEA). Included are the impact of major laws, key court decisions, and the construction of the FDA's supplement actions and rules from the 1920s to the 1990s for products that were neither drugs nor typical foods. Stiff resistance to the regulations by supplement manufacturers, trade associations, politicians, and especially the public at large is an important part of this story. The paper closes with the passage of DSHEA and how it literally changed the definition and parameters of control of dietary supplements. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  2. Law regulations concerning food supplements, dietetic food and novel food containing herbal substances

    Directory of Open Access Journals (Sweden)

    Baraniak Justyna

    2016-12-01

    Full Text Available Food supplements are concentrated sources of nutrients and/or other substances with a nutritional or physiological effect. However, they often contain herbal substances or their preparations. Food supplements belong to category of food and for that reason are regulated by food legislation. European Union regulations and directives established general directions for dietary supplements, dietetic food, which due to their special composition or manufacturing process are prepared for specific groups of people with special nutritional needs, and novel food/novel food ingredients to ensure product safety, suitability and appropriate consumer information.

  3. Report on Contractual Flow Down Provisions in the Federal Acquisition Regulation (FAR) and Defense Federal Acquisition Regulation Supplement (DFARS)

    Science.gov (United States)

    2017-11-01

    Each subcontract required non- disclosure agreements (NDAs) with the prime. 5 2. Flow-Down Clauses FAR/DFARS flow-down clauses derive from the...unusual for the prime contractor to only account for 10–20 percent of the total MDAP cost. Subcontractors—inclusive of basic parts and material suppliers...that feed the upper tiers of the supply chain— account for the bulk of the defense industrial base.7 MDAP prime contractors are often viewed as

  4. 78 FR 17176 - Federal Acquisition Regulation; Defense Base Act

    Science.gov (United States)

    2013-03-20

    ... Regulation; Defense Base Act AGENCIES: Department of Defense (DoD), General Services Administration (GSA... the Defense Base Act. DATES: Interested parties should submit written comments to the Regulatory... Act as extended by the Defense Base Act. II. Discussion and Analysis The Defense Base Act of 1941...

  5. 78 FR 34020 - Federal Acquisition Regulation; Uniform Procurement Identification

    Science.gov (United States)

    2013-06-06

    ...: Submit comments in response to FAR Case 2012-023 by any of the following methods: Regulations.gov : http... defined to mean a distinct six- position code consisting of a combination of alpha and/or numeric... 17 alpha and/or numeric characters configured to convey certain information. Positions one through...

  6. 76 FR 81408 - Contractor Legal Management Requirements; Acquisition Regulations

    Science.gov (United States)

    2011-12-28

    ... DEPARTMENT OF ENERGY 10 CFR Part 719 48 CFR Parts 931, 952 and 970 RIN 1990-AA37 Contractor Legal... Energy (DOE or Department) is proposing to revise existing regulations covering contractor legal... costs by certain contractors whose contracts exceed $100,000,000 as well as legal counsel retained...

  7. 78 FR 25795 - Contractor Legal Management Requirements; Acquisition Regulations

    Science.gov (United States)

    2013-05-03

    ... DEPARTMENT OF ENERGY 10 CFR Part 719 48 CFR Parts 931, 952, and 970 RIN 1990-AA37 Contractor Legal.... ACTION: Final rule. SUMMARY: The Department of Energy revises existing regulations covering contractor... costs by certain contractors whose contracts exceed $100,000,000 as well as legal counsel retained...

  8. 76 FR 48776 - Federal Acquisition Regulation; Documenting Contractor Performance; Correction

    Science.gov (United States)

    2011-08-09

    ... Regulation; Documenting Contractor Performance; Correction AGENCY: Department of Defense (DoD), General... published in the Federal Register of June 28, 2011, regarding the proposed rule for Documenting Contractor... published in the Federal Register of June 28, 2011, regarding the proposed rule for Documenting Contractor...

  9. 77 FR 63805 - Federal Acquisition Regulation; Information Collection; Service Contracting

    Science.gov (United States)

    2012-10-17

    ... use of appropriate technological collection techniques or other forms of information technology. DATES... all correspondence related to this collection. All comments received will be posted without change to http://www.regulations.gov , including any personal and/or business confidential information provided...

  10. An innovative model for regulating supplement products: Natural health products in Canada

    International Nuclear Information System (INIS)

    Nestmann, Earle R.; Harwood, Melody; Martyres, Stephanie

    2006-01-01

    On 1 January 2004, Health Canada officially added a new term to the global list of synonyms for dietary supplements: natural health products (NHP). Developed with the intent of providing Canadian consumers with ready access to NHP that are safe, effective, and of high quality, the Natural Health Products Regulations (the NHP regulations) are applicable to the sale, manufacture, packaging, labelling, importation, distribution, and storage of NHP, and are administered by the recently formed Natural Health Products Directorate (NHPD) within Health Canada. This paper provides an overview of the process for regulating supplement products in Canada

  11. 75 FR 34282 - Federal Acquisition Regulation; FAR Case 2009-013, Nonavailable Articles

    Science.gov (United States)

    2010-06-16

    ...-AL40 Federal Acquisition Regulation; FAR Case 2009-013, Nonavailable Articles AGENCIES: Department of... revise the list of articles determined to be domestically nonavailable. DATES: Effective Date: July 16.... SUPPLEMENTARY INFORMATION: A. Background The Buy American Act does not apply with respect to articles, materials...

  12. 75 FR 38675 - Federal Acquisition Regulation; FAR Case 2008-011, Government Property

    Science.gov (United States)

    2010-07-02

    ... contractor to use the property on an independent research and development (IR&D) program rent free, if-- (a... Government for all property acquired or fabricated by the Contractor in accordance with the financing...-0029; Sequence 1] RIN 9000-AL41 Federal Acquisition Regulation; FAR Case 2008-011, Government Property...

  13. 76 FR 63896 - Federal Acquisition Regulation; Privacy Training, 2010-013

    Science.gov (United States)

    2011-10-14

    ... should a breach occur; and (7) Any agency-specific privacy training requirements. (d) The contractor is... Acquisition Regulation; Privacy Training, 2010-013 AGENCY: Department of Defense (DoD), General Services... contractors to complete training that addresses the protection of privacy, in accordance with the Privacy Act...

  14. 78 FR 27239 - General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial...

    Science.gov (United States)

    2013-05-09

    ... Services Administration Acquisition Regulation; Submission for OMB Review; Industrial Funding Fee and Sales... Budget (OMB) a request to review and approve a reinstatement of a previously approved information collection requirement regarding industrial funding fee and sales reporting. A notice was published in the...

  15. 75 FR 13129 - General Services Administration Acquisition Regulation; Submission for OMB Review; Sales Practice...

    Science.gov (United States)

    2010-03-18

    ... Services Administration Acquisition Regulation; Submission for OMB Review; Sales Practice Format--Supplies and/or Services With an Established Catalog Price and Sales Practices Format-- Supplies and/or... will be submitting to the Office of Management and Budget (OMB) a request to review and approve a new...

  16. 77 FR 44063 - Federal Acquisition Regulations; DARPA-New Mexico Tax Agreement

    Science.gov (United States)

    2012-07-26

    ... Federal Acquisition Regulation (FAR) to add the United States Defense Advanced Research Projects Agency... Mexico (NM). The DARPA-NM tax agreement eliminates the double taxation of Government cost-reimbursement... 2012- 019. SUPPLEMENTARY INFORMATION: I. Background On August 18, 2011, DARPA and the Taxation and...

  17. 77 FR 58380 - General Services Administration Acquisition Regulation; Submission for OMB Review; Price...

    Science.gov (United States)

    2012-09-20

    ...] General Services Administration Acquisition Regulation; Submission for OMB Review; Price Reductions Clause... requirement regarding the GSAR Price Reductions Clause. A notice was published in the Federal Register at 76... identified by Information Collection 3090- 0235, Price Reduction Clause, by any of the following methods...

  18. 77 FR 17352 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Science.gov (United States)

    2012-03-26

    ...-AL97 Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program Correction In rule...) * * * -- (24) 52.219-29, Notice of Set-Aside for Economically Disadvantaged Women-Owned Small Business (EDWOSB... Disadvantaged Women- Owned Small Business Concerns. * * * * * Notice of Set-Aside for Economically Disadvantaged...

  19. 78 FR 37692 - Federal Acquisition Regulation; Contracting With Women-Owned Small Business Concerns

    Science.gov (United States)

    2013-06-21

    ...-AM59 Federal Acquisition Regulation; Contracting With Women-Owned Small Business Concerns AGENCY... disadvantaged women-owned small business concerns and to women-owned small business concerns eligible under the Women-owned Small Business Program. DATES: Effective Date: June 21, 2013. Comment Date: Interested...

  20. 76 FR 68039 - Federal Acquisition Regulation; Successor Entities to the Netherlands Antilles

    Science.gov (United States)

    2011-11-02

    ...] RIN 9000-AM11 Federal Acquisition Regulation; Successor Entities to the Netherlands Antilles AGENCIES... ``designated country'' due to the change in status of the islands that comprised the Netherlands Antilles... 2011-014. SUPPLEMENTARY INFORMATION: I. Background The Netherlands Antilles was designated as a...

  1. 75 FR 4565 - Federal Acquisition Regulation; Submission for OMB Review; Right of First Refusal of Employment

    Science.gov (United States)

    2010-01-28

    .... Please cite OMB Control No. 9000-0114, Right of First Refusal of Employment, in all correspondence. Dated... ADMINISTRATION [OMB Control No. 9000-0114] Federal Acquisition Regulation; Submission for OMB Review; Right of... previously approved information collection requirement concerning right of first refusal of employment. A...

  2. 75 FR 10267 - Federal Acquisition Regulation; Submission for OMB Review; Contractor Use of Interagency Motor...

    Science.gov (United States)

    2010-03-05

    ... ADMINISTRATION [OMB Control No. 9000-0032] Federal Acquisition Regulation; Submission for OMB Review; Contractor... previously approved information collection requirement concerning contractor use of interagency motor pool... contracting officer may authorize cost-reimbursement contractors to obtain, for official purposes only...

  3. 76 FR 31416 - Federal Acquisition Regulation; Oversight of Contractor Ethics Programs

    Science.gov (United States)

    2011-05-31

    ...-AL92 Federal Acquisition Regulation; Oversight of Contractor Ethics Programs AGENCY: Department of... that contractors have implemented the mandatory contractor business ethics program requirements. DATES... to Improve DoD's Oversight of Contractor Ethics Programs. The ethics program requirement flows from...

  4. 78 FR 6189 - Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor Excise...

    Science.gov (United States)

    2013-01-29

    ... 9000-AM13 Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor... contractor in order to reimburse the tax imposed (26 U.S.C. 5000C Note). On February 22, 2012, DoD, GSA, and... with the statute, FAR 31.205-41 is amended to inform the Government and contractors that the costs of...

  5. 75 FR 28771 - Federal Acquisition Regulation; FAR Case 2009-027, Personal Identity Verification of Contractor...

    Science.gov (United States)

    2010-05-24

    ... Acquisition Regulation; FAR Case 2009-027, Personal Identity Verification of Contractor Personnel AGENCIES... of collecting from contractors all forms of Government provided identification once they are no..., titled Controls Over the Contractor Common Access Card (CAC) Life Cycle, was performed to determine...

  6. 75 FR 82575 - Federal Acquisition Regulation; Personal Identity Verification of Contractor Personnel

    Science.gov (United States)

    2010-12-30

    ... 9000-AL60 Federal Acquisition Regulation; Personal Identity Verification of Contractor Personnel AGENCY... requirement of collecting from contractors all forms of Government-provided identification once they are no...D Inspector General Audit Report No. D-2009-005, entitled ``Controls Over the Contractor Common...

  7. 78 FR 60169 - Federal Acquisition Regulation; Pilot Program for Enhancement of Contractor Employee...

    Science.gov (United States)

    2013-09-30

    ... 9000-AM56 Federal Acquisition Regulation; Pilot Program for Enhancement of Contractor Employee... program enhancing whistleblower protections for contractor employees. DATES: Effective: September 30, 2013... contractor employees at FAR subpart 3.9. The pilot program is mandated by section 828, entitled ``Pilot...

  8. 77 FR 10461 - Federal Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor Excise...

    Science.gov (United States)

    2012-02-22

    ... Acquisition Regulation; Unallowability of Costs Associated With Foreign Contractor Excise Tax AGENCIES.... Additionally, the law stipulates that no funds are to be disbursed to any foreign contractor in order to... payment. Additionally, the law stipulates that no funds are to be disbursed to any foreign contractor in...

  9. 77 FR 47797 - Federal Acquisition Regulation; Small Business Set Asides for Research and Development Contracts

    Science.gov (United States)

    2012-08-10

    ... Acquisition Regulation; Small Business Set Asides for Research and Development Contracts AGENCY: Department of... when the market research conducted in accordance with FAR part 10 indicates there are small businesses... officer can proceed with a small business set-aside for research and development. FAR 19.502-2(b...

  10. 77 FR 5714 - Office of Procurement and Property Management; Agriculture Acquisition Regulation, Labor Law...

    Science.gov (United States)

    2012-02-06

    ... Management; Agriculture Acquisition Regulation, Labor Law Violations; Withdrawal AGENCY: Office of... 422.70 entitled ``Labor Law Violations'' that would have a contractor certify upon accepting a contract that it is in compliance with all applicable labor laws and that, to the best of its knowledge...

  11. 48 CFR 252.231-7000 - Supplemental cost principles.

    Science.gov (United States)

    2010-10-01

    ... principles. 252.231-7000 Section 252.231-7000 Federal Acquisition Regulations System DEFENSE ACQUISITION... of Provisions And Clauses 252.231-7000 Supplemental cost principles. As prescribed in 231.100-70, use the following clause: Supplemental Cost Principles (DEC 1991) When the allowability of costs under...

  12. [Food supplements on the Hungarian market: regulations of marketing and of the composition of the products].

    Science.gov (United States)

    Lugasi, Andrea; Horacsek, Márta; Martos, Eva

    2010-09-26

    According to recent legislation, food supplements are foodstuffs with the purpose of supplementing normal diet. Food supplements are concentrated sources of nutrients such as vitamins and minerals and other substances with a physiological or nutritional effect. In Hungary, marketing of food supplements has not been bound to pre-market authorization since joining to the European Union. The food business operator, who is responsible for production or distribution of the product, must notify it at National Institute for Food and Nutrition Science latest at the time when the product has been placed on the market and it can be distributed simultaneously. Distribution, ingredients, and all those information which appear on the label are determined by numerous regulations and prescriptions but at the same time the lack of harmonized legislation at certain places may cause a lot of problems on Community level. The first part of the study shows the laws and regulations influencing the distribution and ingredients of food supplements, while the main target of the second part is to introduce the evaluation process of components from nutritional and physiological point of view, and the role played by the food supplements in nutrition.

  13. 78 FR 31551 - Federal Acquisition Regulation; Submission for OMB Review; Commerce Patent Regulations

    Science.gov (United States)

    2013-05-24

    ...; Submission for OMB Review; Commerce Patent Regulations AGENCIES: Department of Defense (DOD), General... collection requirement concerning Department of Commerce patent regulations. A notice was published in...- 0095, Commerce Patent Regulations, by any of the following methods: Regulations.gov : http://www...

  14. Regulations for the safe transport of radioactive material. 1985 ed. Supplement 1988

    International Nuclear Information System (INIS)

    1988-01-01

    A major revision of the Agency's Regulations for the Safe Transport of Radioactive Material, Safety Series No. 6, was undertaken during a period of several years, culminating in the publication of the 1985 Edition. In order to consider minor problems in the new edition, the Agency convened a panel of experts in January 1986. This panel recommended some amendments which were subsequently published as Supplement 1986 to the Regulations. A further review panel meeting took place in June 1987. The amendments which were recommended for early adoption were themselves divided into two kinds. The first of these are designated as minor changes. The second kind of amendment recommended for early adoption comprises actual changes to regulatory provisions. Several changes of this second type were recommended by the panel and are included in this Supplement. The Supplement also contains the amended texts of the supporting documents, Safety Series Nos 7, 37 and 80, which are necessary to correct minor errors as well as to provide complementary information for the changes introduced to the Regulations themselves. In addition, the Supplement embodies the contents of Supplement 1986, which is consequently superseded.

  15. A two-component system regulates hemin acquisition in Porphyromonas gingivalis.

    Directory of Open Access Journals (Sweden)

    Jodie C Scott

    Full Text Available Porphyromonas gingivalis is a Gram-negative oral anaerobe associated with infection of the periodontia. The organism has a small number of two-component signal transduction systems, and after comparing genome sequences of strains W83 and ATCC 33277 we discovered that the latter was mutant in histidine kinase (PGN_0752, while the cognate response regulator (PGN_0753 remained intact. Microarray-based transcriptional profiling and ChIP-seq assays were carried out with an ATCC 33277 transconjugant containing the functional histidine kinase from strain W83 (PG0719. The data showed that the regulon of this signal transduction system contained genes that were involved in hemin acquisition, including gingipains, at least three transport systems, as well as being self-regulated. Direct regulation by the response regulator was confirmed by electrophoretic mobility shift assays. In addition, the system appears to be activated by hemin and the regulator acts as both an activator and repressor.

  16. 48 CFR 752.231-71 - Salary supplements for HG employees.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Salary supplements for HG....231-71 Salary supplements for HG employees. As prescribed in 731.205-71, for use in all contracts with... sub-contracts. Salary Supplements for HG Employees (OCT 1998) (a) Salary supplements are payments made...

  17. How to Assist Formalization of NL Regulations: Lessons from Business Rules Acquisition Experiments

    OpenAIRE

    Nazarenko , Adeline

    2013-01-01

    International audience; Decision systems usually rely on a set of business rules that describe the expected behavior of a system or an organization and that determine the decisions to be taken in different situations. However, rule acquisition is often the bottleneck that hinders the development of decision systems. When these rules are based on regulations written in Natural Language (NL), one solution is to derive formal business rules from the source documents. This approach also allows ch...

  18. Regulations applicable to plant food supplements and related products in the European Union.

    Science.gov (United States)

    Silano, Vittorio; Coppens, Patrick; Larrañaga-Guetaria, Ainhoa; Minghetti, Paola; Roth-Ehrang, René

    2011-12-01

    This paper deals with the current regulatory and legal settings of traditional plant food supplements and herbal medicinal products in the European Union (EU). Marketing of botanicals in foods and food supplements in the EU is subject to several provisions of food law, which cover aspects of safety, production, labelling and product composition, including the use of additives and maximum levels of contaminants and residues. However, due to limited harmonization at the EU level, specific national regulations adopted at a Member State level also apply and mutual recognition is the mechanism through which such products can be marketed in EU countries other than those of origin. Unlike food supplements, marketing of traditional herbal medicinal products is regulated by an ad hoc Directive (i.e. Directive 2004/24/EC) covering in detail all the relevant aspects of these products, including a facilitated registration procedure at national level. However, by distinguishing traditional herbal medicinal products from plant food supplements and establishing selective marketing modalities for these two product categories, the EU has been confronted with implementation difficulties for traditional herbal medicinal products and a lack of homogeneity in the regulatory approaches adopted in different EU Member States. In fact, currently the nature of the commercial botanical products made available to consumers as traditional medicinal products or food supplements, depends largely on the EU Member State under consideration as a consequence of how competent National Authorities and manufacturing companies interpret and apply current regulations rather than on the intrinsic properties of the botanical products and their constituents. When the EU approach is compared with approaches adopted in some non-European countries to regulate these product categories, major differences become evident.

  19. THE EFFECT OF n-3 LC-PUFA SUPPLEMENTATION ON TENNIS SKILL ACQUISITION IN 10-12 YEAR OLD GIRLS

    Directory of Open Access Journals (Sweden)

    Asuman Şahan

    2012-07-01

    Full Text Available The purpose of this study was to investigate the effects of 16 weeks of n-3 LC-PUFA (omega 3 long-chain polyunsaturated fatty acid supplementation on tennis skill acquisition in 10-12 year old girls. This research was a single-blind placebo-controlled trial. 29 girls (10-12 years of age who had never played tennis before took part in the study. Ball Throws to the Target (BTT and Tennis Ability Test (TAT were performed three times. Before participants were allocated to the groups and received n-3 LC-PUFA or olive oil, they underwent preparatory training for three weeks. Anthropometric measurements, nutrition analysis, and 1st BTT and TAT tests were performed and they continued the preparatory training until the 3rd week. Then they were randomly allocated to two groups to receive either n-3 LC-PUFA (omega group; 670 mg · day-1; n=16 or olive oil (placebo group; 670 mg · day-1; n=13 during 16 weeks of tennis training which involved 3 hours per week for 19 weeks. The results show that significant improvements in TAT were found in both groups but the omega group had significantly higher scores than the placebo group at the 3rd measurements. Although there were no differences between groups at all measurements of BTT, the omega group showed significant improvement between the 1st and 3rd measurements. This study suggests that daily 670 mg n-3 LC-PUFA supplementation for 16 weeks might improve tennis ability test scores of 10-12 year old girls.

  20. 76 FR 58149 - Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card® and...

    Science.gov (United States)

    2011-09-20

    ..., was not subject to review under Section 6(b) of Executive Order 12866, Regulatory Planning and Review... 80% of ``marina-type merchants'' are considered small businesses. Marina-type merchants accepting the SEA Card[reg] will pay a normal fee to the banking institution or processing center, similar to VISA...

  1. 76 FR 21849 - Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card® and...

    Science.gov (United States)

    2011-04-19

    ..., therefore, was not subject to review under Section 6(b) of Executive Order 12866, Regulatory Planning and... their home station. Approximately 80% of ``marina-type merchants'' are considered small businesses. Marina-type merchants accepting the SEA Card[supreg] will pay a normal fee to the banking institution or...

  2. Organ acquisition cost centers Part I: medicare regulations--truth or consequence.

    Science.gov (United States)

    Abecassis, M

    2006-12-01

    Organ Acquisition Cost Centers (OACC) were designed to encourage and incentivize hospitals to provide transplantation services. The purpose of this article (Part I) is to familiarize transplant professionals and transplant center administrators with the regulations that govern OACC. An historical perspective of the evolution of these regulations is necessary to better understand the basic principles underlying this complex area of transplant finance. There is a wide variation in transplant center OACC reporting, suggesting under-reporting by some and overreporting by others. Correct reporting is essential since OACC are auditable. We have surveyed 13 audits by the Office of the Inspector General (OIG) of transplant center OACC in an attempt to identify trends in reporting practices by transplant centers that are not deemed acceptable by the OIG. We discuss these findings in the context of some basic definitions that refer specifically to cost accounting principles necessary for accurate reporting of OACC.

  3. Chemometrics and chromatographic fingerprints to classify plant food supplements according to the content of regulated plants.

    Science.gov (United States)

    Deconinck, E; Sokeng Djiogo, C A; Courselle, P

    2017-09-05

    Plant food supplements are gaining popularity, resulting in a broader spectrum of available products and an increased consumption. Next to the problem of adulteration of these products with synthetic drugs the presence of regulated or toxic plants is an important issue, especially when the products are purchased from irregular sources. This paper focusses on this problem by using specific chromatographic fingerprints for five targeted plants and chemometric classification techniques in order to extract the important information from the fingerprints and determine the presence of the targeted plants in plant food supplements in an objective way. Two approaches were followed: (1) a multiclass model, (2) 2-class model for each of the targeted plants separately. For both approaches good classification models were obtained, especially when using SIMCA and PLS-DA. For each model, misclassification rates for the external test set of maximum one sample could be obtained. The models were applied to five real samples resulting in the identification of the correct plants, confirmed by mass spectrometry. Therefore chromatographic fingerprinting combined with chemometric modelling can be considered interesting to make a more objective decision on whether a regulated plant is present in a plant food supplement or not, especially when no mass spectrometry equipment is available. The results suggest also that the use of a battery of 2-class models to screen for several plants is the approach to be preferred. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. β-Adrenergic Receptors Regulate the Acquisition and Consolidation Phases of Aversive Memory Formation Through Distinct, Temporally Regulated Signaling Pathways.

    Science.gov (United States)

    Schiff, Hillary C; Johansen, Joshua P; Hou, Mian; Bush, David E A; Smith, Emily K; Klein, JoAnna E; LeDoux, Joseph E; Sears, Robert M

    2017-03-01

    Memory formation requires the temporal coordination of molecular events and cellular processes following a learned event. During Pavlovian threat (fear) conditioning (PTC), sensory and neuromodulatory inputs converge on post-synaptic neurons within the lateral nucleus of the amygdala (LA). By activating an intracellular cascade of signaling molecules, these G-protein-coupled neuromodulatory receptors are capable of recruiting a diverse profile of plasticity-related proteins. Here we report that norepinephrine, through its actions on β-adrenergic receptors (βARs), modulates aversive memory formation following PTC through two molecularly and temporally distinct signaling mechanisms. Specifically, using behavioral pharmacology and biochemistry in adult rats, we determined that βAR activity during, but not after PTC training initiates the activation of two plasticity-related targets: AMPA receptors (AMPARs) for memory acquisition and short-term memory and extracellular regulated kinase (ERK) for consolidating the learned association into a long-term memory. These findings reveal that βAR activity during, but not following PTC sets in motion cascading molecular events for the acquisition (AMPARs) and subsequent consolidation (ERK) of learned associations.

  5. Response of appetite and potential appetite regulators following intake of high energy nutritional supplements.

    Science.gov (United States)

    Fatima, Sadia; Gerasimidis, Konstantinos; Wright, Charlotte; Tsiountsioura, Melina; Arvanitidou, Eirini-Iro; Malkova, Dalia

    2015-12-01

    The net clinical benefit of high-energy nutritional supplements (HENSDs) consumption is lower than expected. To investigate the extent to which consumption of oral HENSD in the fasted state reduces energy intake in slim females during consecutive breakfast and lunch, and whether this relates to changes in appetite and metabolic appetite regulators. Twenty three females of 24.4 ± 2.8 years with BMI of 18.2 ± 0.8 kg/m(2) consumed HENSD (2.5 MJ) or PLACEBO (0.4 MJ) in fasted state in a single blind randomized cross-over study. Appetite and metabolic rate measurements and blood collection were conducted prior to and during 240 min after the intake of the supplements. Energy intake was recorded during ad libitum buffet breakfast and lunch served 60 min and 240 min post supplementation respectively. Energy intake during breakfast was significantly (P appetite measures were not significantly different between HENSD and PLACEBO trials. Correlations for the within participant relations between the responses of plasma hormones and appetite scores were significant (P < 0.05) for PYY and insulin but not CCK. The energy expended above resting metabolic rate was significantly (P < 0.05) higher in the HENDS trial but relative increase in energy expenditure was not significantly different between the two trials. Oral high-energy nutritional supplements have a partial and relatively short lived suppressive action on energy intake and can be expected to increase net energy intake by approximately half the energy value of the supplement consumed. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  6. 75 FR 54524 - Defense Federal Acquisition Regulation Supplement; Guidance on Personal Services (DFARS Case 2009...

    Science.gov (United States)

    2010-09-08

    ... parts 211 and 237 are being amended to (1) require that statements of work or performance work statements clearly distinguish between Government employees and contractor employees and (2) ensure that... Department, including several checklists currently used. This interim rule adopts best practices and...

  7. 77 FR 39141 - Defense Federal Acquisition Regulation Supplement: Applicability of Hexavalent Chromium Policy to...

    Science.gov (United States)

    2012-06-29

    ... final rule was published, DoD became aware of a drafting oversight and the need to correct the text of... Act, 5 U.S.C. 601, et seq., because this rule is just correcting a drafting oversight in rule 2009..., Technical Data--Commercial Items (DEC 2011), if applicable (see 227.7102-4(a)), if flow down is required in...

  8. 78 FR 28780 - Defense Federal Acquisition Regulation Supplement: Detection and Avoidance of Counterfeit...

    Science.gov (United States)

    2013-05-16

    ... clause at FAR 52.244-2, Subcontracts. (1) Unallowability of costs of rework and corrective action. A new... cost of rework or corrective action that may be required to remedy the use or inclusion of such parts... such products and for any rework or corrective action that may be required to remedy the use or...

  9. 76 FR 12666 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Science.gov (United States)

    2011-03-08

    ... presentation per company or organization; (4) Last four digits of social security number for each person.../dars/government_furnished_property.html and submit the following information: (1) Company or...

  10. 76 FR 11985 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Science.gov (United States)

    2011-03-04

    ...) Company or organization name; (2) Full names of persons attending; (3) Identity if desiring to speak; limit to a 10-minute presentation per company or organization; (4) Last four digits of social security...

  11. 76 FR 61279 - Defense Federal Acquisition Regulation Supplement; Defense Cargo Riding Gang Member (DFARS Case...

    Science.gov (United States)

    2011-10-04

    ... that the language of the proposed clause be amended to read as follows to reinforce DoD's role in the... Military Sealift Command), and specific procedural guidance for DoD personnel obtaining the background... 247.5. B. Language Inconsistency Comment: DFARS 252.247-7027(a) defines ``riding gang member'' as it...

  12. 76 FR 71831 - Defense Federal Acquisition Regulation Supplement: Fire-Resistant Fiber for Production of...

    Science.gov (United States)

    2011-11-18

    ..., suppliers, or distributors of fire-resistant fibers, yarns, fabrics, or military uniforms) submitted.... The law does not restrict DoD's selection and use of fabrics containing fire-resistant rayon fiber... from selecting fabrics that include fire- resistant rayon fibers. Response: These responses have...

  13. 75 FR 20825 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot...

    Science.gov (United States)

    2010-04-21

    ... suppliers; and (3) foster the establishment of long-term business relationships between protege firms and... technology. The Office of Management and Budget (OMB) has approved this information collection for use...

  14. 78 FR 19467 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Science.gov (United States)

    2013-04-01

    ... subcontractors and suppliers; and (3) foster the establishment of long-term business relationships between... technology. The Office of Management and Budget (OMB) has approved this information collection for use...

  15. 77 FR 76941 - Defense Federal Acquisition Regulation Supplement: New Qualifying Country-Poland (DFARS Case 2012...

    Science.gov (United States)

    2012-12-31

    ... discriminatory barriers to procurements of supplies and services produced by industrial enterprises of the other....003 is amended in paragraph (10), the definition of ``qualifying country'' by adding in alphabetical... place; 0 b. In paragraph (a), the definition of ``qualifying country'', by adding, in alphabetical order...

  16. 76 FR 25569 - Defense Federal Acquisition Regulation Supplement; Minimizing the Use of Materials Containing...

    Science.gov (United States)

    2011-05-05

    ... implement the guidance in contract requirements. This rule is intended for DoD program managers and... change it. The rule will help to remedy this problem. Subpart 223.7203 of the rule provides direction for.... While the company has had success with marketing the process to commercial airlines and the Air Force...

  17. 78 FR 13604 - Defense Federal Acquisition Regulation Supplement: Encouragement of Science, Technology...

    Science.gov (United States)

    2013-02-28

    ..., either formal or informal, that encourage the pursuit of education and experience in the science..., programs or initiatives, either formal or informal, which encourage the pursuit of education and experience... Title I schools in order to enhance STEM education and programs; Making personnel available to advise...

  18. 75 FR 75444 - Defense Federal Acquisition Regulation Supplement; Government Property (DFARS Case 2009-D008)

    Science.gov (United States)

    2010-12-03

    ... clauses. (a) Use the clause at 252.245-7000, Government-Furnished Mapping, Charting, and Geodesy Property, in solicitations and contracts when mapping, charting, and geodesy property is to be furnished. (b... Government-Furnished Mapping, Charting, and Geodesy Property. As prescribed in 245.107(a), use the following...

  19. 76 FR 6003 - Defense Federal Acquisition Regulation Supplement; Marking of Government-Furnished Property

    Science.gov (United States)

    2011-02-02

    ...-7000, Government-Furnished Mapping, Charting, and Geodesy Property, in solicitations and contracts when mapping, charting, and geodesy property is to be furnished. (b) Use the clause at 252.245-7001, Tagging...

  20. 75 FR 9563 - Defense Federal Acquisition Regulation Supplement; Safeguarding Unclassified Information (DFARS...

    Science.gov (United States)

    2010-03-03

    ... exfiltration, minimally including the following: (i) Current and regularly updated malware protection services... data exfiltration, as follows: (A) Current and regularly updated malware protection services, e.g... ingress, egress, and exfiltration through technologies such as firewalls and router policies, intrusion...

  1. 76 FR 58142 - Defense Federal Acquisition Regulation Supplement; Passive Radio Frequency Identification (DFARS...

    Science.gov (United States)

    2011-09-20

    ... following commodities, when shipped in rail tank cars, tanker trucks, trailers, other bulk wheeled... during shipment and storage. It can be a unit pack or a container with a combination of unit packs or... tag means a tag that reflects energy from the reader/interrogator or that receives and temporarily...

  2. 76 FR 71823 - Defense Federal Acquisition Regulation Supplement: Responsibility and Liability for Government...

    Science.gov (United States)

    2011-11-18

    .... The purpose of the DFARS rule is to standardize policy for negotiated fixed-price contracts, whether.... Response: The intent of this rule is to standardize policy treatment for negotiated FAR part 15 fixed-price... (``assumption of risk''). The current exception to this policy (see FAR 45.104) is for negotiated fixed-price...

  3. 78 FR 68830 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Service...

    Science.gov (United States)

    2013-11-15

    ... or other forms of information technology. The Office of Management and Budget (OMB) has approved this... Services. The provision at DFARS 252.237- 7024 requires offerors to submit with its offer a written plan describing how it will continue to perform essential contractor services during periods of crisis. The...

  4. 75 FR 76295 - Defense Federal Acquisition Regulation Supplement; Restrictions on the Use of Mandatory...

    Science.gov (United States)

    2010-12-08

    ..., including assault and battery, intentional infliction of emotional distress, false imprisonment, or.... Regulatory Flexibility Act DoD has prepared a final regulatory flexibility analysis consistent with 5 U.S.C. 604. A copy of the analysis may be obtained from the point of contact specified herein. The analysis...

  5. 75 FR 27946 - Defense Federal Acquisition Regulation Supplement; Restrictions on the Use of Mandatory...

    Science.gov (United States)

    2010-05-19

    ... harassment, including assault and battery, intentional infliction of emotional distress, false imprisonment... Flexibility Act DoD has prepared an initial regulatory flexibility analysis consistent with 5 U.S.C. 603. A copy of the analysis may be obtained from the point of contact specified herein. The analysis is...

  6. 76 FR 11411 - Defense Federal Acquisition Regulation Supplement; Multiyear Contracting (DFARS Case 2009-D026)

    Science.gov (United States)

    2011-03-02

    ... economic order quantity procurement, are merged into 217.170, General, and 217.172, Multiyear contracts for... guided by the following principles when entering into a multiyear contract for services: (1) The portion... authorized by law (10 U.S.C. 2306b and 10 U.S.C. 2306c). A multiyear supply contract may be authorized by an...

  7. 75 FR 22727 - Defense Federal Acquisition Regulation Supplement; Government-Assigned Serial Number Marking...

    Science.gov (United States)

    2010-04-30

    ... 252.211-7003, Item Identification and Valuation, and that require the contractor to mark major end... existing DoD property management, logistics, and maintenance systems. This regulatory action was subject to... operational necessity. The latest version of MIL-STD-130, Marking of U.S. Military Property, shall be used for...

  8. 75 FR 59102 - Defense Federal Acquisition Regulation Supplement; Government-Assigned Serial Number Marking...

    Science.gov (United States)

    2010-09-27

    ... version of MIL-STD-130, Marking of U.S. Military Property, shall be used for the marking of human-readable... Valuation; and (2) Require the contractor to mark major end items under the terms and conditions of the... revising the introductory text to read as follows: 252.211-7003 Item identification and valuation. As...

  9. 75 FR 20954 - Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest in Major...

    Science.gov (United States)

    2010-04-22

    ... Definition: Adding a new definition of ``organizational conflict of interest'' refers to the types of... necessary to identify conflicts are contained in section 203.1204, entitled Types of organizational... conflicts of interest. This section explains the three types of OCIs as recognized by the GAO and the Court...

  10. 75 FR 52917 - Defense Federal Acquisition Regulation Supplement (DFARS); Warranty Tracking of Serialized Items...

    Science.gov (United States)

    2010-08-30

    ... Business Communication Council (EHIBCC) and Health Industry Business Communication Council (HIBCC), as... Communication Council (EHIBCC) and Health Industry Business Communication Council (HIBCC), as indicated in the... Communication Council (EHIBCC) and Health Industry Business Communication Council (HIBCC). (h) Warranty...

  11. 76 FR 58138 - Defense Federal Acquisition Regulation Supplement (DFARS); Alternative Line Item Structure (DFARS...

    Science.gov (United States)

    2011-09-20

    ... DoD published a proposed rule in the Federal Register at 76 FR 21847 on April 19, 2011, to add DFARS..., the contract line item may be for a desktop computer, but the actual items delivered, invoiced, and..., Desktop with 20 EA CPU, Monitor, Keyboard and Mouse. Alternative line-item structure offer where monitors...

  12. 75 FR 32637 - Defense Federal Acquisition Regulation Supplement; Trade Agreements Thresholds (DFARS Case 2009...

    Science.gov (United States)

    2010-06-08

    ... exceeding) exceeding) WTO GPA $203,000 $7,804,000 FTAs: Australia FTA 70,079 7,804,000 Bahrain FTA 203,000 9,110,318 CAFTA-DR (Costa Rica, Dominican 70,079 7,804,000 Republic, El Salvador, Guatemala, Honduras, and Nicaragua) Chile FTA 70,079 7,804,000 Morocco FTA 203,000 7,804,000 NAFTA: --Canada 25,000 9,110...

  13. 78 FR 79620 - Defense Federal Acquisition Regulation Supplement; Trade Agreements Thresholds (DFARS Case 2013...

    Science.gov (United States)

    2013-12-31

    ... GPA 204,000 7,864,000 FTAs: Australia FTA 79,507 7,864,000 Bahrain FTA 204,000 10,335,931 CAFTA-DR (Costa Rica, 79,507 7,864,000 Dominican Republic, El Salvador, Guatemala, Honduras, and Nicaragua...

  14. 78 FR 48407 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Quality Assurance...

    Science.gov (United States)

    2013-08-08

    ... Notification. The Contractor agrees to notify the Contracting Officer in writing immediately of any breach of... Notification. The Contractor agrees to notify the Contracting Officer in writing immediately of any breach of... basic and alternates of DFARS clauses will facilitate the use of automated contract writing systems. The...

  15. 75 FR 60690 - Defense Federal Acquisition Regulation Supplement (DFARS); Electronic Ordering Procedures (DFARS...

    Science.gov (United States)

    2010-10-01

    ... event of conflict between a delivery order or task order and this contract, the contract shall control.... This change will ultimately help improve the management and promotion of electronic Government services... impose any information collection requirements that require the approval of the Office of Management and...

  16. 76 FR 11410 - Defense Federal Acquisition Regulation Supplement; Increase the Use of Fixed-Price Incentive...

    Science.gov (United States)

    2011-03-02

    ... military departments and directors of defense agencies on obtaining greater efficiency and productivity in defense spending. In support of this initiative, DoD is proposing to amend DFARS subpart 216.4 to require...

  17. 78 FR 73450 - Defense Federal Acquisition Regulation Supplement: Preparation of Letter of Offer and Acceptance...

    Science.gov (United States)

    2013-12-06

    ... effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance of quantifying both costs... prospective contractors, and therefore require relocation to the DFARS. The objective of this rule is to...,000 and use FMS funds. There is no required reporting or recordkeeping. The rule requires the...

  18. 78 FR 28793 - Defense Federal Acquisition Regulation Supplement: Preparation of Letter of Offer and Acceptance...

    Science.gov (United States)

    2013-05-16

    ... emphasizes the importance of quantifying both costs and benefits, of reducing costs, of harmonizing rules... contractors, and therefore require relocation to the DFARS. The objective of this rule is to provide direction... of noncompetitive contract awards to small business entities that exceed $10,000 and use FMS funds...

  19. 78 FR 65244 - Defense Federal Acquisition Regulation Supplement: Contractor Personnel Supporting U.S. Armed...

    Science.gov (United States)

    2013-10-31

    ... it with the changes in applicability, terminology, and other revisions made by Department of Defense..., terminology aid in determining which groups qualify for different types of Government support and are based on.... In the past, the provision of non-emergency medical and dental care to CAAF personnel has generated...

  20. 75 FR 81908 - Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest in Major...

    Science.gov (United States)

    2010-12-29

    ... strategy, the apparently successful offeror will be able to provide objective and unbiased advice. Refining the definition of ``major subcontractor'' to include upper and lower limits on application of the... pricing data threshold would not be considered a major subcontract; and [cir] A subcontract equal to or...

  1. 76 FR 66889 - Defense Federal Acquisition Regulation Supplement; Safeguarding Unclassified DoD Information...

    Science.gov (United States)

    2011-10-28

    ...). ACTION: Notice of meeting. SUMMARY: DoD is hosting a public meeting to initiate a dialogue with industry... not presently address the safeguarding of unclassified DoD information within industry, nor does it... processed through security in a timely fashion. Prior registrants will be given priority if room constraints...

  2. 76 FR 61282 - Defense Federal Acquisition Regulation Supplement; Definition of “Qualifying Country End Product...

    Science.gov (United States)

    2011-10-04

    ..., Austria, Belgium, Canada, Denmark, Egypt, Finland, France, Germany, Greece, Israel, Italy, Luxembourg...: Australia, Austria, Belgium, Canada, Denmark, Egypt, Finland, France, Germany, Greece, Israel, Italy...

  3. 76 FR 38089 - Defense Federal Acquisition Regulation Supplement; Safeguarding Unclassified DoD Information...

    Science.gov (United States)

    2011-06-29

    ... Defense Contract Audit Agency audit; (ii) By DoD Offices of the Inspector General as part of pending or on...-3 MA-4(6) SC-4. AC-3(4) Audit & Identification and MA-5 SC-7. Accountability. Authentication. AC-4... determined). [[Page 38095

  4. 77 FR 30361 - Defense Federal Acquisition Regulation Supplement; Defense Trade Cooperation Treaty With the...

    Science.gov (United States)

    2012-05-22

    ... challenging and time consuming for U.S. exporters and for foreign firms in their supply chains. The U.S..., public health and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance... that requires the approval of the Office of Management and Budget under 44 U.S.C. chapter 35, the net...

  5. 75 FR 9114 - Defense Federal Acquisition Regulation Supplement; Additional Requirements Applicable to...

    Science.gov (United States)

    2010-03-01

    ... Council, Crystal Square 4, Suite 200A, 241 18th Street, Arlington, VA 22202-3402. Comments received.... (ix) In the case of a contract with a cancellation ceiling in excess of $100 million, if the budget... cancellation ceiling established in the contract-- (A) The head of the agency shall, as part of this...

  6. 76 FR 64902 - Defense Federal Acquisition Regulation Supplement; Ownership of Offeror

    Science.gov (United States)

    2011-10-19

    ... the ability to understand the corporate structure and affiliations of its suppliers. DoD is seeking... dialogue with industry and Government agencies about developing a method by which offerors, if owned or controlled by another business entity, can identify to DoD the Commercial and Government Entity (CAGE) code...

  7. 78 FR 59325 - Defense Federal Acquisition Regulation Supplement: Further Implementation of Trafficking in...

    Science.gov (United States)

    2013-09-26

    ... whistleblowing). The revised clause would retain the $5 million threshold and the exclusion for commercial items... subpart 3.9, from retribution for whistleblowing on trafficking in persons violations. (End of provision...

  8. 76 FR 32846 - Defense Federal Acquisition Regulation Supplement; Representation Relating to Compensation of...

    Science.gov (United States)

    2011-06-06

    ... written post-employment ethics opinion before receiving compensation from a contractor. It also applies to... procurement integrity for DoD. 3. DFARS 203.171-3 is an implementation of section 847 of the NDAA for FY 2008... receiving compensation from the contractor, the post- employment ethics opinion regarding post-employment...

  9. 76 FR 21852 - Defense Federal Acquisition Regulation Supplement; Responsibility and Liability for Government...

    Science.gov (United States)

    2011-04-19

    ... regulatory approaches that maximize net benefits (including potential economic, environmental, public health... substantial cash reserves may be in a financial position that enables those firms to select a high insurance deductible in order to garner lower premiums by electing to become self-insuring for potential property loss...

  10. 77 FR 39140 - Defense Federal Acquisition Regulation Supplement: Shipping Instructions (DFARS Case 2011-D052)

    Science.gov (United States)

    2012-06-29

    ... origin contracts, Export Traffic Release regardless of FOB terms, or foreign military sales shipments...) Shipping documents covering f.o.b. origin shipments. (i) Procedures for the contractor to obtain bills of...

  11. 78 FR 18877 - Defense Federal Acquisition Regulation Supplement; Specialty Metals-Definition of “Produce...

    Science.gov (United States)

    2013-03-28

    ..., research and development necessary to meet the needs of the U.S. military, thereby reducing the possibility... metal powders produced through atomization would not be sufficient to confer domestic origin on the... preceding the definition headings of ``Alloy''; ``Assembly''; ``Commercial derivative military article...

  12. 78 FR 63461 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Foreign...

    Science.gov (United States)

    2013-10-24

    ... 252.225-7010, Commercial Derivative Military Article-- Specialty Metals Compliance Certificate, as... commercial derivative military articles to the Government. DFARS 252.225-7013, Duty-Free Entry, as prescribed... of origin. DFARS 252.225-7020, Trade Agreements Certificate, as prescribed in 225.1101(5), requires...

  13. 77 FR 4637 - Defense Federal Acquisition Regulation Supplement: Shipping Instructions (DFARS Case 2011-D052)

    Science.gov (United States)

    2012-01-30

    .... origin contracts, Export Traffic Release regardless of f.o.b. terms, or foreign military sales shipments... use the DD Form 1659 when using the clauses at FAR 52.242-10, F.o.b. Origin--Government Bills of Lading or Prepaid Postage, or 52.242-11, F.o.b. Origin-- Government Bills of Lading or Indicia Mail...

  14. 75 FR 33195 - Defense Federal Acquisition Regulation Supplement; New Designated Country-Taiwan-DFARS Case 2009...

    Science.gov (United States)

    2010-06-11

    ... Organization Government Procurement Agreement. DATES: Effective date: June 11, 2010. FOR FURTHER INFORMATION..., Taiwan became a designated country under the World Trade Organization Government Procurement Agreement... World Trade Organization Government Procurement Agreement countries in the trade agreement provisions...

  15. 77 FR 19128 - Defense Federal Acquisition Regulation Supplement: Separation of Combined Provisions and Clauses...

    Science.gov (United States)

    2012-03-30

    .... (2) Use the provision at 252.229-7013, Tax Exemptions (Spain)-- Representation, in solicitations that... (Spain)--representation. As prescribed in 229.402-70(e)(2), use the following clause: TAX EXEMPTIONS...)--Representation. 252.229-7005, Tax Exemptions (Spain)... 252.229-7013, Tax Exemptions (Spain)--Representation...

  16. 77 FR 35883 - Defense Federal Acquisition Regulation Supplement; Contractors Performing Private Security...

    Science.gov (United States)

    2012-06-15

    .... The essence of the definition cannot be changed substantially in the DFARS from that in the... recommended that the final rule define the contractor's obligation to cooperate, as in the mandatory... define the scope and limitations of the contractor's obligation to cooperate with Government...

  17. 75 FR 22729 - Defense Federal Acquisition Regulation Supplement; Reporting of Government Property Lost, Stolen...

    Science.gov (United States)

    2010-04-30

    ...-based processes to greater use of automation. This proposed rule revises requirements for all DoD... identified in the contract, or in the absence of such identification, the item's fair-market value... of material, equipment, special tooling, special test equipment, and real property. (b) Policy for...

  18. 76 FR 7782 - Defense Federal Acquisition Regulation Supplement; Rules of the Armed Services Board of Contract...

    Science.gov (United States)

    2011-02-11

    ... Rule 6 Pleadings Rule 7 Amendments of Pleadings or Record Rule 8 Hearing Election Rule 9 Prehearing... Hearings Rule 19 Unexcused Absence of a Party Rule 20 Hearings: Nature, Examination of Witnesses Rule 21... thereon. (b) The Board may entertain and rule upon other appropriate motions. Rule 6. Pleadings (a...

  19. 76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Rules of the Armed Services Board of Contract...

    Science.gov (United States)

    2011-05-11

    ..., Organization, Forwarding, and Status of Appeal File Rule 5 Motions Rule 6 Pleadings Rule 7 Amendments of Pleadings or Record Rule 8 Hearing Election Rule 9 Prehearing Briefs Rule 10 Prehearing or Presubmission... Party Rule 20 Hearings: Nature, Examination of Witnesses Rule 21 Subpoenas Rule 22 Copies of Papers Rule...

  20. 78 FR 28790 - Defense Federal Acquisition Regulation Supplement; Forward Pricing Rate Proposal Adequacy...

    Science.gov (United States)

    2013-05-16

    ... not duplicate, overlap, or conflict with any other Federal rules. IV. Paperwork Reduction Act The rule... result of economic conditions and increased competitiveness; c. Changes in accounting policies... format that is consistent with the accounting system used to accumulate actual expenses? 16. FAR 15.408...

  1. 75 FR 32642 - Defense Federal Acquisition Regulation Supplement; Ground and Flight Risk Clause (DFARS Case 2007...

    Science.gov (United States)

    2010-06-08

    ... relating to wear and tear or deterioration, or to the extent the loss or damage is caused by negligence of... negligence of Government personnel; or (ii) Twenty percent of the price or estimated cost of this contract...

  2. 75 FR 69360 - Defense Federal Acquisition Regulation Supplement; Award-Fee Reductions for Health and Safety...

    Science.gov (United States)

    2010-11-12

    ... acts with gross negligence or reckless disregard for health or safety, causing serious bodily injury or... which actions of gross negligence or reckless disregard of health or safety by the contractor or its... or death of any civilian or military personnel of the Government through gross negligence or with...

  3. 76 FR 57674 - Defense Federal Acquisition Regulation Supplement; Award Fee Reduction or Denial for Health or...

    Science.gov (United States)

    2011-09-16

    ... the contractor's or subcontractor's gross negligence or with reckless disregard for the safety of... that jeopardize the health and safety of Government personnel, through gross negligence or reckless... injury through gross negligence or with reckless disregard for the safety of such personnel, this final...

  4. 76 FR 72916 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Science.gov (United States)

    2011-11-28

    ... information collection requires contractors to comply with the notification process at DFARS clause 252.204... purposes. The U.S.-IAEA Additional Protocol permits the United States unilaterally to declare exclusions from inspection requirements for activities with direct national security significance. The clause at...

  5. 76 FR 61296 - Defense Federal Acquisition Regulation Supplement: Contracting With the Canadian Commercial...

    Science.gov (United States)

    2011-10-04

    ... rule implements a recommendation of a bilateral integrated product team on cost or pricing data..., redefined ``cost or pricing data'' to mean all cost or pricing data and added a new term for ``certified... pricing data'' was generally replaced with the new term ``certified cost or pricing data.'' The same final...

  6. 75 FR 59411 - Defense Federal Acquisition Regulation Supplement; Patents, Data, and Copyrights (DFARS Case 2010...

    Science.gov (United States)

    2010-09-27

    ....'' The items ``design details, algorithms, processes, flow charts, formulas, and related material that... services has been expanded to cover rights in architectural designs, shop drawings, or similar information... in Shop Drawings. Of particular note is the inclusion of architectural works in the list of examples...

  7. 75 FR 35684 - Defense Federal Acquisition Regulation Supplement; Ownership or Control by a Foreign Government...

    Science.gov (United States)

    2010-06-23

    ... Undersecretary of Defense for Intelligence. Additionally, subparagraph (a)(4) of DFARS 252.209-7002, Disclosure... Flexibility Act, 5 U.S.C. 601 et seq., because it only impacts companies that are owned or controlled by a... or controlled by a foreign government. DoD invites comments from small business concerns and other...

  8. 76 FR 25565 - Defense Federal Acquisition Regulations Supplement; Guidance on Personal Services (DFARS Case...

    Science.gov (United States)

    2011-05-05

    ... program manager, or equivalent, certification that the service contract requirement does not include an... a boundary separating contractor and government employees in all workplace environments.'' Response... potential economic, environmental, public health and safety effects, distributive impacts, and equity...

  9. 77 FR 30998 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Government...

    Science.gov (United States)

    2012-05-24

    ..., Government Property, DFARS section 211.274, Reporting of Government-Furnished Equipment in the DoD Item... surplus Government property. Under paragraph (b), a contractor may be directed by the plant clearance... plant clearance officer to purchase or retain Government property at less than cost if the plant...

  10. 78 FR 73451 - Defense Federal Acquisition Regulation Supplement: Unallowable Fringe Benefit Costs (DFARS Case...

    Science.gov (United States)

    2013-12-06

    ... contract. Penalties may be waived in accordance with FAR 42.709-5(c). 9. Exceeding the Actual Costs of... not face the possibility of False Claims Act prosecutions, Civil False Claims Act damages, qui tam... possibility of False Claims Act prosecutions, Civil False Claims Act damages, qui tam lawsuits or debarment...

  11. 76 FR 38047 - Defense Federal Acquisition Regulation Supplement; Extension of Restrictions on the Use of...

    Science.gov (United States)

    2011-06-29

    ... work) in excess of $1 million, if the contractor restricts its employees to arbitration for claims... both costs and benefits, of reducing costs, of harmonizing rules, and of promoting flexibility. This is... rule under 5 U.S.C. 804. III. Regulatory Flexibility Act The Regulatory Flexibility Act does not apply...

  12. 77 FR 74177 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Production...

    Science.gov (United States)

    2012-12-13

    .../index.htm . Paper copies are available from Ms. Meredith Murphy, OUSD (AT&L) DPAP (DARS), IMD 3C132... material management and accounting systems conform to established DoD standards. c. The information... to establish, maintain, and disclose material management and accounting systems. c. DFARS 252.247...

  13. 75 FR 14095 - Defense Federal Acquisition Regulation Supplement; Appendix A, Armed Services Board of Contract...

    Science.gov (United States)

    2010-03-24

    ..., significant precedential importance, or serious dispute within the normal decision process for decision by the... will participate in financing the Board's operations on an equal basis and to the extent determined by...

  14. 77 FR 52254 - Defense Federal Acquisition Regulation Supplement: Reporting of Government-Furnished Property...

    Science.gov (United States)

    2012-08-29

    ... comments in the development of the final rule. A discussion of the comments and the changes made to the... eventual demise of other, existing property management systems. The respondent specifically recommended...

  15. 76 FR 72327 - NASA Federal Acquisition Regulation Supplement; Responsibility, Suspension and Debarment

    Science.gov (United States)

    2011-11-23

    .... 13563 emphasizes the importance of quantifying both costs and benefits, of reducing costs, of..., was not subject to review under section 6(b) of E.O. 12866, Regulatory Planning and Review, dated... require the approval of the Office of Management and Budget under the Paperwork Reduction Act (44 U.S.C...

  16. 76 FR 33170 - Defense Federal Acquisition Regulation Supplement; Inclusion of Option Amounts in Limitations on...

    Science.gov (United States)

    2011-06-08

    ..., distributive impacts, and equity). Executive Order 13563 emphasizes the importance of quantifying both costs... 12866, Regulatory Planning and Review, dated September 30, 1993. This rule is not a major rule under 5 U... Management and Budget under the Paperwork Reduction Act (44 U.S.C. chapter 35). List of Subjects in 48 CFR...

  17. 76 FR 23504 - Defense Federal Acquisition Regulation Supplement; Definition of Multiple-Award Contract (DFARS...

    Science.gov (United States)

    2011-04-27

    ... Order 13563 emphasizes the importance of quantifying both costs and benefits, of reducing costs, of..., was not subject to review under Section 6(b) of Executive Order 12866, Regulatory Planning and Review... collection requirements that require the approval of the Office of Management and Budget under the Paperwork...

  18. 78 FR 76993 - Defense Federal Acquisition Regulation Supplement: Photovoltaic Devices (DFARS Case 2014-D006)

    Science.gov (United States)

    2013-12-20

    ... DFARS, some questions have arisen as to where the substantial transformation of some solar panels occurs... contract exceeds $25,000, the Offeror's certification that such photovoltaic device (e.g., solar panel) is...

  19. 76 FR 58150 - Defense Federal Acquisition Regulations Supplement; Discussions Prior to Contract Award (DFARS...

    Science.gov (United States)

    2011-09-20

    ... addressing valid industry concerns and a constructive alternative to protests resulting from industry... able to avoid the costs associated with protesting. The rule does not duplicate, overlap, or conflict...

  20. 76 FR 11363 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Science.gov (United States)

    2011-03-02

    ... the recipient to decompile, disassemble, or reverse engineer the software, or use software decompiled... engineer the software, or use software decompiled, disassembled, or reverse engineered by the Government... Government shall not permit the recipient to decompile, disassemble, or reverse engineer the software, or use...

  1. 77 FR 4631 - Defense Federal Acquisition Regulation Supplement: New Designated Country-Armenia (DFARS Case...

    Science.gov (United States)

    2012-01-30

    ... necessary, to select regulatory approaches that maximize net benefits (including potential economic... aspect of this collection of information, including suggestions for reducing the burden, in response to..., Slovenia, Spain, Sweden, Switzerland, Taiwan (known in the World Trade Organization as ``the Separate...

  2. 78 FR 28785 - Defense Federal Acquisition Regulation Supplement: Only One Offer-Further Implementation (DFARS...

    Science.gov (United States)

    2013-05-16

    ... certified cost or pricing data from the Canadian Commercial Corporation. DATES: Comment date: Comments on... than certified cost or pricing data from the Canadian Commercial Corporation. This case is a follow-on... & Logistics in a memorandum dated November 3, 2010, Implementation Directive for Better Buying Power...

  3. 76 FR 75512 - Defense Federal Acquisition Regulation Supplement: Proposal Adequacy Checklist (DFARS Case 2011...

    Science.gov (United States)

    2011-12-02

    ... of certified cost or pricing data. DATES: Comments on the proposed rule should be submitted in... of DoD's Better Buying Power initiatives by incorporating the requirement for a proposal adequacy... require the submission of certified cost or pricing data. II. Executive Orders 12866 and 13563 Executive...

  4. 78 FR 65220 - Defense Federal Acquisition Regulation Supplement: New Designated Country-Croatia (DFARS Case...

    Science.gov (United States)

    2013-10-31

    ... as a new designated country under the World Trade Organization Government Procurement Agreement (WTO..., 2012, the WTO Committee on Government Procurement accepted the European Union notification indicating..., this rule adds Croatia to the list of World Trade Organization Government Procurement Agreement...

  5. 76 FR 78858 - Defense Federal Acquisition Regulation Supplement; Utilization of Domestic Photovoltaic Devices...

    Science.gov (United States)

    2011-12-20

    ... Government Procurement Agreement (WTO GPA) country (Aruba, Austria, Belgium, Bulgaria, Canada, Cyprus, Czech... of Subjects in 48 CFR Parts 212, 225, and 252 Government procurement. Ynette R. Shelkin, Editor... (see FAR 25.4). (2) World Trade Organization--Government Procurement Agreement. For covered contracts...

  6. 77 FR 30355 - Defense Federal Acquisition Regulation Supplement: United States-Korea Free Trade Agreement...

    Science.gov (United States)

    2012-05-22

    ... already a designated country under the WTO GPA. Although the rule now opens up Government procurement to... Korea is already party to the World Trade Organization Government Procurement Agreement. DATES... note)). The Republic of Korea is already party to the World Trade Organization Government Procurement...

  7. 76 FR 14587 - Defense Federal Acquisition Regulation Supplement; Multiyear Contract Authority for Electricity...

    Science.gov (United States)

    2011-03-17

    ... cost effectiveness of the proposed purchase has been made based upon a business case analysis, and (2... determined, on the basis of a business case analysis prepared by DoD, that-- (1) The proposed purchase of electricity under such contract is cost effective; and (2) It would not be possible to purchase electricity...

  8. 76 FR 21847 - Defense Federal Acquisition Regulation Supplement (DFARS), Alternative Line-Item Structure (DFARS...

    Science.gov (United States)

    2011-04-19

    ... with CPU, 20 EA Monitor, Keyboard and Mouse. Alternative line-item structure offer where monitors are... CPU, 20 EA Keyboard and Mouse. 0002 Monitor 20 EA (End of provision)] [FR Doc. 2011-8966 Filed 4-18-11... problems in the receipt and acceptance phase for contract deliverables and payments. This group determined...

  9. 77 FR 35921 - Defense Federal Acquisition Regulation Supplement: Item Unique Identifier Update (DFARS Case 2011...

    Science.gov (United States)

    2012-06-15

    ... lifecycle to strengthen supply chain integrity, enhance cyber security and combat counterfeiting. 4. Section... include your name, company name (if any), and ``DFARS Case 2011-D055'' on your attached document. [cir... businesses registered in the Item Unique Identification Registry, out of 2,431 total companies registered...

  10. 75 FR 10191 - Defense Federal Acquisition Regulation Supplement (DFARS); DFARS Case 2009-D017, Continuation of...

    Science.gov (United States)

    2010-03-05

    ..., Crystal Square 4, Suite 200A, 241 18th Street, Arlington, VA 22202- 3402. Comments received generally will.... Affected Public: Businesses or other for-profit institutions. Frequency: On occasion. Respondent's... during an extended event, such as a pandemic that occurs in repeated waves; (ii) The time lapse...

  11. 75 FR 48276 - Defense Federal Acquisition Regulation Supplement; Management of Unpriced Change Orders

    Science.gov (United States)

    2010-08-10

    ... to make requirements for DoD management and oversight of unpriced change orders consistent with those... management and oversight of undefinitized contract actions (UCAs). In the current DFARS, unpriced change... procedures. The rule makes requirements for DoD management and oversight of unpriced change orders consistent...

  12. 76 FR 71826 - Defense Federal Acquisition Regulation Supplement: Representation Relating to Compensation of...

    Science.gov (United States)

    2011-11-18

    ... diligence to prevent and detect criminal conduct and otherwise promote an organizational culture that..., 2011, at 76 FR 32846. However, a ``think tank'' requested the ``addition of language making it clear...

  13. 76 FR 52131 - Defense Federal Acquisition Regulation Supplement; Nonavailability Exception for Procurement of...

    Science.gov (United States)

    2011-08-19

    ... Performing Private Security Functions (DFARS Case 2011-D023), Identification of Critical Safety Items (DFARS.... companies could then do a better job of planning, including the ramp-up of supply to ensure availability..., Government demand planners are able to produce a 12-month forecast in order to assist the industry in...

  14. 75 FR 71646 - Defense Federal Acquisition Regulation Supplement; Annual Representations and Certifications...

    Science.gov (United States)

    2010-11-24

    ... Act DoD does not expect this proposed rule to have a significant economic impact on a substantial...-7031, Secondary Arab Boycott of Israel. This provision applies to all solicitations unless an exception...

  15. 78 FR 76067 - Defense Federal Acquisition Regulation Supplement: Item Unique Identifier Update (DFARS Case 2011...

    Science.gov (United States)

    2013-12-16

    ... emphasizes the importance of quantifying both costs and benefits, of reducing costs, of harmonizing rules...) Ensures item level traceability throughout lifecycle to strengthen supply chain integrity, enhance cyber security, and combat counterfeiting. 0 3. Section 211.274-2 is amended by-- 0 a. Revising the section...

  16. 76 FR 71465 - Defense Federal Acquisition Regulations Supplement; Notification Requirements for Awards of...

    Science.gov (United States)

    2011-11-18

    ...-order contract award concerns intelligence or intelligence- related activities of DoD, notification shall also be provided to the Select Committee on Intelligence of the Senate and Permanent Select Committee on Intelligence of the House of Representatives. II. Discussion and Analysis of Public Comments A...

  17. 78 FR 69273 - Defense Federal Acquisition Regulation Supplement: Safeguarding Unclassified Controlled Technical...

    Science.gov (United States)

    2013-11-18

    ... not align with the protection requirements in the NISPOM. 3. Policy Regarding Outsourcing, Cloud... contractors and on international information sharing agreements. Response: The technical information covered... be applied to all systems. Comments also indicated that DFARS should not apply to International...

  18. 76 FR 6006 - Defense Federal Acquisition Regulation Supplement; Reporting of Government Property Lost, Stolen...

    Science.gov (United States)

    2011-02-02

    ... rarely occurs. Similarly, a respondent stated the need to address the materiality of the loss and that... pertaining to Government property losses. It does not require reporting of the estimated harm or materiality... assigned by the Government and identified in the contract; and adds the method for determining the...

  19. 75 FR 51416 - Defense Federal Acquisition Regulation Supplement; Transportation (DFARS Case 2003-D028)

    Science.gov (United States)

    2010-08-20

    ...) Take into consideration that the 1904 Act is, in part, a subsidy of the U.S.-flag commercial shipping... commercial reasonableness of vessel positioning required); and (4) Any other relevant economic and financial considerations. (ii) The contracting officer must forward the report to-- (A) The Commander, MSC, through the...

  20. 75 FR 80426 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Science.gov (United States)

    2010-12-22

    ... data base for capturing records of Government-furnished property sent on a non-reimbursable basis to a... number. (vii) Medium code; how the data is recorded, e.g., barcode, contact memory button. (viii) Value... January 1, 2004, for unique item identifier pedigree data established at delivery, as defined by DFARS 252...

  1. 78 FR 18865 - Defense Federal Acquisition Regulation Supplement: Proposal Adequacy Checklist (DFARS Case 2011...

    Science.gov (United States)

    2013-03-28

    ... inconsistencies with your established estimating and accounting principles and procedures?'' Checklist item 4 is... costs?'' and now includes the list of eight sample factors that appear in the definition of ``cost or... 10 has added the phrase ``including breakdown by year'' after ``consistent with your cost accounting...

  2. 76 FR 78874 - Defense Federal Acquisition Regulation Supplement: Title 41 Positive Law Codification-Further...

    Science.gov (United States)

    2011-12-20

    ... Labor Standards. Apply Service Contract Labor Standards clauses and minimum wage and fringe benefit... Rate Requirements clauses and minimum wage requirements to all contract service calls or orders for... contracts. (a) Apply both the Service Contract Labor Standards statute and the Construction Wage Rate...

  3. 77 FR 35879 - Defense Federal Acquisition Regulation Supplement: Title 41 Positive Law Codification-Further...

    Science.gov (United States)

    2012-06-15

    ... clauses and minimum wage and fringe benefit requirements to all contract service calls or orders for such... statute. Apply Construction Wage Rate Requirements clauses and minimum wage requirements to all contract... statute and the Construction Wage Rate Requirements statute to installation support contracts if...

  4. 76 FR 64885 - Defense Federal Acquisition Regulation Supplement: Reporting of Government-Furnished Property...

    Science.gov (United States)

    2011-10-19

    ... Accounting Procedures manual, along with a hyperlink to the URL. It is not necessary to add condition code...D items and will be available to users in the logistics, financial, and property accountability... emphasizes the importance of quantifying both costs and benefits, of reducing costs, of harmonizing rules...

  5. 75 FR 2457 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Science.gov (United States)

    2010-01-15

    ... element of an acceptable estimating system. * * * * * (c) * * * (3) The auditor conducts estimating system... as contained in 252.215-7002(d). * * * * * (f) The ACO, in consultation with the auditor, shall-- (1... findings--(1) Reporting of audit findings. The auditor shall document findings and recommendations in a...

  6. 78 FR 48397 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Transportation (DFARS...

    Science.gov (United States)

    2013-08-08

    ...(a)(4)(vii)), document the oral orders in accordance with department or agency instructions. (g) The... conditions easier to read and understand. By placing alternates in full text, all paragraph substitutions... small businesses, expending more time to become familiar with and to understand the new format of...

  7. 76 FR 58140 - Defense Federal Acquisition Regulation Supplement; Annual Representations and Certifications...

    Science.gov (United States)

    2011-09-20

    ... Boycott of Israel. (ix) 252.225-7035, Buy American Act--Free Trade Agreements--Balance of Payments Program... Arab Boycott of Israel. ----(vi) 252.225-7035, Buy American Act--Free Trade Agreements-- Balance of...

  8. 76 FR 9680 - Defense Federal Acquisition Regulation Supplement; Limitations on Procurements With Non-Defense...

    Science.gov (United States)

    2011-02-22

    ... for Fiscal Year 2010. Section 806 authorizes an agency that is an element of the intelligence... certifies that this final rule will not have a significant economic impact on a substantial number of small... Under Joint Programs with Intelligence Community, amends the limitations placed on procurements by non...

  9. 78 FR 37980 - Defense Federal Acquisition Regulation Supplement: Solicitation Provisions and Contract Clauses...

    Science.gov (United States)

    2013-06-25

    ... contractual obligations. b. Specific Clause Flowdown Requirements Comment: One respondent commented that if... to excessive practice by the primes to flowdown any and all clauses to satisfy its contractual obligations. Response: DoD has retained in the final rule the language at 252.244-7000(b), which is the same...

  10. 76 FR 9714 - Defense Federal Acquisition Regulation Supplement; Passive Radio Frequency Identification (DFARS...

    Science.gov (United States)

    2011-02-22

    ... operational rations. (ii) Class II--Clothing, individual equipment, tentage, organizational tool kits, hand... multiple submissions (one for each shipment), it takes only 1.12 seconds per response. The changes proposed...) Subclass of Class I--Packaged operational rations. (B) Class II--Clothing, individual equipment, tentage...

  11. 76 FR 52133 - Defense Federal Acquisition Regulation Supplement; Contractors Performing Private Security...

    Science.gov (United States)

    2011-08-19

    ... Outside the United States.'' DFARS 225.302-3, Definitions, provides the definition of ``private security... this total, 361, or 20 percent, were awarded to small businesses. Firms performing private security... private security functions in response to a perceived immediate threat; (2) Ensure that all employees of...

  12. 75 FR 56961 - Defense Federal Acquisition Regulation Supplement; Material Inspection and Receiving Report...

    Science.gov (United States)

    2010-09-17

    ... requires clerical and analytic skills to create the documents and input them into the electronic WAWF... DD Form 250 MIRR. To permit verification of motor deliveries, assign each load a load number which...) Shipping point; (3) Consignee; (4) Contract and line item number; (5) Product identification; (6) Gross...

  13. Detection of regulated herbs and plants in plant food supplements and traditional medicines using infrared spectroscopy.

    Science.gov (United States)

    Deconinck, E; Djiogo, C A Sokeng; Bothy, J L; Courselle, P

    2017-08-05

    The identification of a specific toxic or regulated plant in herbal preparations or plant food supplements is a real challenge, since they are often powdered, mixed with other herbal or synthetic powders and compressed into tablets or capsules. The classical identification approaches based on micro- and macroscopy are therefore not possible anymore. In this paper infrared spectroscopy, combined with attenuated total reflectance was evaluated for the screening of plant based preparations for nine specific plants (five regulated and four common plants for herbal supplements). IR and NIR spectra were recorded for a series of self-made triturations of the targeted plants. After pretreatment of the spectral data chemometric classification techniques were applied to both data sets (IR and NIR) separately and the combination of both. The results show that the screening of herbal preparations or plant food supplements for specific plants, using infrared spectroscopy, is feasible. The best model was obtained with the Mid-IR data, using SIMCA as modelling technique. During validation of the model, using an external test set, 21 of 25 were correctly classified and six of the nine targeted plants showed no misclassifications for the selected test set. For the other three a success rate of 50% was obtained. Mid-IR combined with SIMCA can therefore be applied as a first step in the screening of unknown samples, before applying more sophisticated fingerprint approaches or identification tests described in several national and international pharmacopoeia. As a proof of concept five real suspicious samples were successfully screened for the targeted regulated plants. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. The science and regulations of probiotic food and supplement product labeling.

    Science.gov (United States)

    Sanders, Mary Ellen; Levy, Dan D

    2011-02-01

    Presented by the New York Academy of Sciences, the U.S. Food and Drug Administration (FDA), and the U.S. Office of Dietary Supplements of the National Institutes of Health, the symposium "Probiotic Foods and Supplements: The Science and Regulations of Labeling," was held on June 12, 2010 at the New York Academy of Sciences, New York, NY, the goals of which were to facilitate the exchange of ideas regarding labeling and substantiation of claims for probiotics among academic, industry, and regulatory professionals, and to discuss ways to translate and communicate research results in a truthful way to the consumer and to such health professionals as physicians, pharmacists, and dieticians. The target audience for this symposium included academicians interested in conducting research on the health benefits of probiotics; scientists; communications personnel, and regulatory specialists from companies involved in, or interested in, the marketing of probiotics; U.S. government regulatory experts tasked with oversight of probiotic foods and dietary supplement products; and other experts in the field interested in the development of probiotics for the U.S. market. © 2011 New York Academy of Sciences.

  15. 48 CFR 731.205-71 - Salary supplements for Host Government employees.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Salary supplements for... Contracts With Commercial Organizations 731.205-71 Salary supplements for Host Government employees. (a... fifty percent of its financial support from the government. (b) General. Salary supplement occurs when...

  16. Ironing Out the Unconventional Mechanisms of Iron Acquisition and Gene Regulation in Chlamydia

    Directory of Open Access Journals (Sweden)

    Nick D. Pokorzynski

    2017-09-01

    Full Text Available The obligate intracellular pathogen Chlamydia trachomatis, along with its close species relatives, is known to be strictly dependent upon the availability of iron. Deprivation of iron in vitro induces an aberrant morphological phenotype termed “persistence.” This persistent phenotype develops in response to various immunological and nutritional insults and may contribute to the development of sub-acute Chlamydia-associated chronic diseases in susceptible populations. Given the importance of iron to Chlamydia, relatively little is understood about its acquisition and its role in gene regulation in comparison to other iron-dependent bacteria. Analysis of the genome sequences of a variety of chlamydial species hinted at the involvement of unconventional mechanisms, being that Chlamydia lack many conventional systems of iron homeostasis that are highly conserved in other bacteria. Herein we detail past and current research regarding chlamydial iron biology in an attempt to provide context to the rapid progress of the field in recent years. We aim to highlight recent discoveries and innovations that illuminate the strategies involved in chlamydial iron homeostasis, including the vesicular mode of acquiring iron from the intracellular environment, and the identification of a putative iron-dependent transcriptional regulator that is synthesized as a fusion with a ABC-type transporter subunit. These recent findings, along with the noted absence of iron-related homologs, indicate that Chlamydia have evolved atypical approaches to the problem of iron homeostasis, reinvigorating research into the iron biology of this pathogen.

  17. Reviewing the Effects of l-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis

    Directory of Open Access Journals (Sweden)

    João A.B. Pedroso

    2015-05-01

    Full Text Available Leucine is a well-known activator of the mammalian target of rapamycin (mTOR. Because mTOR signaling regulates several aspects of metabolism, the potential of leucine as a dietary supplement for treating obesity and diabetes mellitus has been investigated. The objective of the present review was to summarize and discuss the available evidence regarding the mechanisms and the effects of leucine supplementation on the regulation of food intake, energy balance, and glucose homeostasis. Based on the available evidence, we conclude that although central leucine injection decreases food intake, this effect is not well reproduced when leucine is provided as a dietary supplement. Consequently, no robust evidence indicates that oral leucine supplementation significantly affects food intake, although several studies have shown that leucine supplementation may help to decrease body adiposity in specific conditions. However, more studies are necessary to assess the effects of leucine supplementation in already-obese subjects. Finally, although several studies have found that leucine supplementation improves glucose homeostasis, the underlying mechanisms involved in these potential beneficial effects remain unknown and may be partially dependent on weight loss.

  18. 75 FR 13422 - Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer...

    Science.gov (United States)

    2010-03-19

    ...-AL26 Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer..., Payments Under Fixed-Price Architect-Engineer Contracts, currently requires contracting officers to... judgment regarding the amount of payment withheld to apply under fixed-price architect-engineer (A-E...

  19. 77 FR 44059 - Federal Acquisition Regulation; Payments Under Time-and-Materials and Labor-Hour Contracts

    Science.gov (United States)

    2012-07-26

    ... receive more frequent payments than every two weeks. The Contractor shall substantiate vouchers (including...] RIN 9000-AM01 Federal Acquisition Regulation; Payments Under Time-and-Materials and Labor-Hour... the authorization to use time-and-materials and labor-hour contract payment requirements. DATES...

  20. 75 FR 13421 - Federal Acquisition Regulation; FAR Case 2008-036, Trade Agreements-Costa Rica, Oman, and Peru

    Science.gov (United States)

    2010-03-19

    ... 9000-AL23 Federal Acquisition Regulation; FAR Case 2008-036, Trade Agreements--Costa Rica, Oman, and... United States-Oman Free Trade Agreement, and the United States-Peru Trade Promotion Agreement. DATES... interim rule. The interim rule added Costa Rica, Oman, and Peru to the definition of ``Free Trade...

  1. The Effects of Self-Regulation on Science Vocabulary Acquisition of English Language Learners with Learning Difficulties

    Science.gov (United States)

    Kim, Woori; Linan-Thompson, Sylvia

    2013-01-01

    This multiple-probe study examined the effects of self-regulation on the acquisition of science vocabulary by four third-grade English language learners (ELLs) with learning difficulties. The students were provided only direct vocabulary instruction in a baseline phase, followed by intervention and maintenance phases into which self-regulation…

  2. Regulations for the safe transport of radioactive material. 1985 ed. Supplement 1986

    International Nuclear Information System (INIS)

    1986-01-01

    Following a six-year effort, a major revision to the Agency's Regulations for the Safe Transport of Radioactive Material (Safety Series No. 6) was issued in 1985. In order to address minor problems with the 1985 Edition of Safety Series No. 6, a panel of experts convened by the International Atomic Energy Agency met from 13 to 17 January 1986. This panel considered minor inconsistencies, omissions or errors that had occurred in the course of preparing the 1985 Edition of Safety Series No. 6, and recommended that two types of change be made. First, changes which will correct errors in the presentation of the text, translation errors (in the French, Russian and Spanish versions of the 1985 Edition), and drafting which failed to express the intent of the panels which reviewed the previous edition of the Regulations; these minor changes are promulgated herewith by the authority of the Director General. Secondly, changes of detail which can only be introduced in accordance with the procedure approved by the Board of Governors on 22 September 1972, which authorizes the Director General to promulgate such changes after giving Governments not less than ninety days' notice and taking into account any comments that they make. Three changes of this second type were recommended by the panel, and were circulated according to the 'ninety-day rule' amendment procedure on 3 February 1986. Those changes which received unanimous support by Member States are included in this Supplement. Corrected text to the 1985 Edition of Safety Series No. 6 (paragraphs, tables, etc.) is provided in this Supplement, and this corrected text supersedes the corresponding portions of the 1985 Edition of Safety Series No. 6.

  3. 77 FR 43077 - Federal Acquisition Regulation; Information Collection; Economic Purchase Quantity-Supplies

    Science.gov (United States)

    2012-07-23

    ... provided. FOR FURTHER INFORMATION CONTACT: Mr. Michael Jackson, Procurement Analyst, Office of Governmentwide Acquisition Policy, (202) 208-4949 or email michaelo.jackson@gsa.gov . SUPPLEMENTARY INFORMATION...

  4. 75 FR 60266 - Federal Acquisition Regulation; Buy American Exemption for Commercial Information Technology...

    Science.gov (United States)

    2010-09-29

    ...). Section 615 authorizes exemption from the Buy American Act for acquisition of information technology that... acquisition of information technology that is a commercial item. This same exemption has appeared every year... applies. ``Information technology'' and ``Commercial item'' are already defined in FAR part 2. This is a...

  5. Microevolution analysis of Bacillus coahuilensis unveils differences in phosphorus acquisition strategies and their regulation

    Directory of Open Access Journals (Sweden)

    Zulema eGómez-Lunar

    2016-02-01

    Full Text Available Bacterial genomes undergo numerous events of gene losses and gains that generate genome variability among strains of the same species (microevolution. Our aim was to compare the genomes and relevant phenotypes of three Bacillus coahuilensis strains from two oligotrophic hydrological systems in the Cuatro Ciénegas Basin (México, to unveil the environmental challenges that this species cope with, and the microevolutionary differences in these genotypes. Since the strains were isolated from a low P environment, we placed emphasis on the search of different phosphorus acquisition strategies. The three B. coahuilensis strains exhibited similar numbers of coding DNA sequences, of which 82% (2, 893 constituted the core genome, and 18% corresponded to accessory genes. Most of the genes in this last group were associated with mobile genetic elements or were annotated as hypothetical proteins. Ten percent of the pangenome consisted of strain-specific genes. Alignment of the three B. coahuilensis genomes indicated a high level of synteny and revealed the presence of several genomic islands. Unexpectedly, one of these islands contained genes that encode the 2-keto-3-deoxymannooctulosonic acid (Kdo biosynthesis enzymes, a feature associated to cell walls of Gram-negative bacteria. Some microevolutionary changes were clearly associated with mobile genetic elements. Our analysis revealed inconsistencies between phenotype and genotype, which we suggest result from the impossibility to map regulatory features to genome analysis. Experimental results revealed variability in the types and numbers of auxotrophies between the strains that could not consistently be explained by in silico metabolic models. Several intraspecific differences in preferences for carbohydrate and phosphorus utilization were observed. Regarding phosphorus recycling, scavenging, and storage, variations were found between the three genomes. The three strains exhibited differences regarding

  6. Endurance exercise and conjugated linoleic acid (CLA supplementation up-regulate CYP17A1 and stimulate testosterone biosynthesis.

    Directory of Open Access Journals (Sweden)

    Rosario Barone

    Full Text Available A new role for fat supplements, in particular conjugated linoleic acid (CLA, has been delineated in steroidogenesis, although the underlying molecular mechanisms have not yet been elucidated. The aims of the present study were to identify the pathway stimulated by CLA supplementation using a cell culture model and to determine whether this same pathway is also stimulated in vivo by CLA supplementation associated with exercise. In vitro, Leydig tumour rat cells (R2C supplemented with different concentrations of CLA exhibited increasing testosterone biosynthesis accompanied by increasing levels of CYP17A1 mRNA and protein. In vivo, trained mice showed an increase in free plasma testosterone and an up-regulation of CYP17A1 mRNA and protein. The effect of training on CYP17A1 expression and testosterone biosynthesis was significantly higher in the trained mice supplemented with CLA compared to the placebo. The results of the present study demonstrated that CLA stimulates testosterone biosynthesis via CYP17A1, and endurance training led to the synthesis of testosterone in vivo by inducing the overexpression of CYP17A1 mRNA and protein in the Leydig cells of the testis. This effect was enhanced by CLA supplementation. Therefore, CLA-associated physical activity may be used for its steroidogenic property in different fields, such as alimentary industry, human reproductive medicine, sport science, and anti-muscle wasting.

  7. Sources of Legal Regulation of Mergers, Acquisitions, Consolidations, Joint Stock Companies in Russia and Corporations in the United States

    Directory of Open Access Journals (Sweden)

    Stanislav E. Kuzmin

    2015-01-01

    Full Text Available The article outlines general characteristics of the sources of law, regulating relations associated with mergers, consolidations, acquisitions of joint stock companies in Russia and corporations in the United States respectively in the Russian legislation and the legislation of the United States and individual States. Both in Russia and in the USA there is a constitutional separation of powers between the Federal authorities and the Subjects of the Federation/States respectively. In both countries legal regulation of mergers and acquisitions of corporations is carried out first of all by a number of laws. These laws fall into three main groups: securities laws, antitrust (competition laws and civil and joint-stock legislation in Russia and corporate laws in the US. All the three groups are federal laws in Russia, while in the US the first two are federal too, but the last one is state laws. It is necessary to highlight the important role of judicial decisions in the United States on legal regulation of mergers, acquisitions, takeovers in comparison with Russia, which is due to the differences in the legal systems of the states in question. However, although Russia is not a state of case law, such legal acts as the resolution of the Plenum of the Supreme Commercial Court will undoubtedly have an impact on law enforcement practice and, consequently, on the regulation of relevant relations. Of particular importance are the findings of the Constitutional Court, whose decisions may cancel acts or their separate provisions provided they are recognized as unconstitutional. Such acts are repealed. Decisions of courts and other bodies based on acts or their separate provisions, recognized by the Constitutional Court of the Russian Federation unconstitutional, are not subject to execution and shall be revised in accordance with the Federal law. The US case law implies existence of a hierarchy of precedents according to which decisions adopted by the

  8. 77 FR 70780 - Federal Acquisition Regulation; Submission for OMB Review; Contractors Performing Private...

    Science.gov (United States)

    2012-11-27

    ... business confidential information provided. FOR FURTHER INFORMATION CONTACT: Mr. Michael O. Jackson, Procurement Analyst, Governmentwide Acquisition Policy, at 202-208-4949 or email michaelo.jackson@gsa.gov...

  9. 78 FR 17670 - Federal Acquisition Regulation; Information Collection; Right of First Refusal of Employment

    Science.gov (United States)

    2013-03-22

    .... FOR FURTHER INFORMATION CONTACT: Mr. Michael O. Jackson, Procurement Analyst, Office of Governmentwide Acquisition Policy GSA, at (202) 208- 4949 or via email at michaelo.jackson@gsa.gov . SUPPLEMENTARY...

  10. 78 FR 38340 - Federal Acquisition Regulation; Submission for OMB Review; Right of First Refusal of Employment

    Science.gov (United States)

    2013-06-26

    ... information provided. FOR FURTHER INFORMATION CONTACT: Mr. Michael O. Jackson, Procurement Analyst, Office of Governmentwide Acquisition Policy, GSA, at (202) 208-4949 or via email at michaelo.jackson@gsa.gov...

  11. Use of Federal Acquisition Regulation. Part 12. Contracts for Applied Research

    National Research Council Canada - National Science Library

    2001-01-01

    ...) Part 12, "Acquisition of Commercial Items,"contracts for acquiring applied research. Applied research involves the scientific efforts to translate basic research into solutions for broadly defined military needs...

  12. Carotenoid supplementation and retinoic acid in immunoglobulin A regulation of the gut microbiota dysbiosis.

    Science.gov (United States)

    Lyu, Yi; Wu, Lei; Wang, Fang; Shen, Xinchun; Lin, Dingbo

    2018-04-01

    Dysbiosis, a broad spectrum of imbalance of the gut microbiota, may progress to microbiota dysfunction. Dysbiosis is linked to some human diseases, such as inflammation-related disorders and metabolic syndromes. However, the underlying mechanisms of the pathogenesis of dysbiosis remain elusive. Recent findings suggest that the microbiome and gut immune responses, like immunoglobulin A production, play critical roles in the gut homeostasis and function, and the progression of dysbiosis. In the past two decades, much progress has been made in better understanding of production of immunoglobulin A and its association with commensal microbiota. The present minireview summarizes the recent findings in the gut microbiota dysbiosis and dysfunction of immunoglobulin A induced by the imbalance of pathogenic bacteria and commensal microbiota. We also propose the potentials of dietary carotenoids, such as β-carotene and astaxanthin, in the improvement of the gut immune system maturation and immunoglobulin A production, and the consequent promotion of the gut health. Impact statement The concept of carotenoid metabolism in the gut health has not been well established in the literature. Here, we review and discuss the roles of retinoic acid and carotenoids, including pro-vitamin A carotenoids and xanthophylls in the maturation of the gut immune system and IgA production. This is the first review article about the carotenoid supplements and the metabolites in the regulation of the gut microbiome. We hope this review would provide a new direction for the management of the gut microbiota dysbiosis by application of bioactive carotenoids and the metabolites.

  13. [Labeling of vitamin and mineral supplements: a revision of the federal normative regulations].

    Science.gov (United States)

    de Carvalho, Patricia Borges; Araújo, Wilma Maria Coelho

    2008-04-01

    In Brazil, there is a steadily increasing offer and demand for products on the basis of vitamins and minerals. According to Brazilian law, the differences in the dosages offered to the consumer in each product are the parameter for its classification as alimentary supplement or medicament. The limit between these two concepts, however, is confusing and lacks clearness. Considering the risk posed by imprudent consumption of such products and seeking to facilitate the interpretation and consolidation of the norms dealing with vitamin and mineral products as well as to create the basis for a master's degree dissertation, a bibliographical survey and evaluation of the entire juridical basis regarding the labeling of these products was conducted. It was concluded that the normative regulations are extensive, complex and of difficult understanding, with a great number of norms dealing with the same subject issued by different authorities. These norms are not consolidated leading to difficult interpretation by retailers, health professionals and consumers and even to failures in the application of these norms by the control authorities. Suggestions are made for helping to correct the failures identified in the study.

  14. 77 FR 55475 - Federal Acquisition Regulation; Information Collection; Permits, Authorities, or Franchises

    Science.gov (United States)

    2012-09-10

    ...; Information Collection; Permits, Authorities, or Franchises AGENCY: Department of Defense (DOD), General... approved information collection requirement concerning permits, authorities, or franchises for regulated..., Authorities, or Franchises, by any of the following methods: Regulations.gov : http://www.regulations.gov...

  15. European regulations on nutraceuticals, dietary supplements and functional foods: A framework based on safety

    International Nuclear Information System (INIS)

    Coppens, Patrick; Fernandes da Silva, Miguel; Pettman, Simon

    2006-01-01

    This article describes the legislation that is relevant in the marketing of functional foods in the European Union (EU), how this legislation was developed as well as some practical consequences for manufacturers, marketers and consumers. It also addresses some concrete examples of how the EU's safety requirements for food products have impacted a range of product categories. In the late nineties, research into functional ingredients was showing promising prospects for the use of such ingredients in foodstuffs. Due mainly to safety concerns, these new scientific developments were accompanied by an urgent call for legislation. The European Commission 2000 White Paper on Food Safety announced some 80 proposals for new and improved legislation in this field. Among others, it foresaw the establishment of a General Food Law Regulation, laying down the principles of food law and the creation of an independent Food Authority endowed with the task of giving scientific advice on issues based upon scientific risk assessment with clearly separated responsibilities for risk assessment, risk management and risk communication. Since then, more than 90% of the White Paper proposals have been implemented. However, there is not, as such, a regulatory framework for 'functional foods' or 'nutraceuticals' in EU Food Law. The rules to be applied are numerous and depend on the nature of the foodstuff. The rules of the general food law Regulation are applicable to all foods. In addition, legislation on dietetic foods, on food supplements or on novel foods may also be applicable to functional foods depending on the nature of the product and on their use. Finally, the two proposals on nutrition and health claims and on the addition of vitamins and minerals and other substances to foods, which are currently in the legislative process, will also be an important factor in the future marketing of 'nutraceuticals' in Europe. The cornerstone of EU legislation on food products, including

  16. 78 FR 303 - General Services Administration Acquisition Regulation; Information Collection; Proposal To Lease...

    Science.gov (United States)

    2013-01-03

    ... that is necessary to satisfy GSA pricing policy requirements. The 1364A-1 is a checklist that addresses... Acquisition Policy Division, GSA (816) 823-2170 or via email at [email protected] . SUPPLEMENTARY... fixed pricing for initial tenant improvements, uses GSA Form 1364C. The 1364C captures an offeror's...

  17. 78 FR 5449 - Federal Acquisition Regulation; Submission of OMB Review; Advance Payments

    Science.gov (United States)

    2013-01-25

    ...; Submission of OMB Review; Advance Payments AGENCIES: Department of Defense (DOD), General Services... requirement concerning advance payments. A notice was published in the Federal Register at 77 FR 43083, on... collection of information is necessary for the proper performance of functions of the Federal Acquisition...

  18. 77 FR 183 - Federal Acquisition Regulation; Preventing Abuse of Interagency Contracts

    Science.gov (United States)

    2012-01-03

    ... ensure a level playing field in the acquisition planning process, the FAR should be amended to require a... the ability of the Government to leverage its purchasing power, e.g., will it have a negative effect... Act also provides authority for placement of orders between major organizational units within an...

  19. 77 FR 57949 - Federal Acquisition Regulation; Positive Law Codification of Title 41

    Science.gov (United States)

    2012-09-18

    ... establishment and use of electronic commerce in Federal acquisition as required by 41 U.S.C. 2301. 4.502... previously approved under the Office of Management and Budget Control Number 1215-0017, titled: Records to be... executive means the individual appointed pursuant to 41 U.S.C. 1702(c) who is responsible for management...

  20. 78 FR 80382 - Federal Acquisition Regulation; Terms of Service and Open-Ended Indemnification and...

    Science.gov (United States)

    2013-12-31

    ... acquisitions for social media applications. DATES: Effective: December 31, 2013. FOR FURTHER INFORMATION... Advocacy of the Small Business Administration did not submit any comments in response to the rule. This rule will impact all small entities with a supply or service contract subject to a supplier license...

  1. 78 FR 69086 - Federal Acquisition Regulation; Submission for OMB Review; Preaward Survey Forms (Standard Forms...

    Science.gov (United States)

    2013-11-18

    .../or business confidential information provided. FOR FURTHER INFORMATION CONTACT: Ms. Cecelia L. Davis... of the information collection would violate the fundamental purposes of the Paperwork Reduction Act... statistics) that were over the simplified acquisition threshold and that did not use FAR part 12 commercial...

  2. 78 FR 45198 - Federal Acquisition Regulation; Submission for OMB Review; Anti-Kickback Procedures

    Science.gov (United States)

    2013-07-26

    ... INFORMATION CONTACT: Ms. Cecelia L. Davis, Procurement Analyst, Office of Governmentwide Acquisition Policy..., Contractor Business Ethics Compliance Program and Disclosure Requirements. Response: It is important to... business. In the normal course of business, a company that is concerned about ethical behavior will take...

  3. 76 FR 68017 - Federal Acquisition Regulation; Preventing Personal Conflicts of Interest for Contractor...

    Science.gov (United States)

    2011-11-02

    ... Contractor Employees Performing Acquisition Functions AGENCIES: Department of Defense (DoD), General Services... personal conflicts of interest by employees of Government contractors as required by statute. DATES... clause for future orders. In the event that a contractor refuses to accept such a modification, the...

  4. 75 FR 13131 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Advantage...

    Science.gov (United States)

    2010-03-18

    ... Electronic Commerce- FACNET AGENCY: Office of the Chief Acquisition Officer, GSA. ACTION: Notice of a request... requirement regarding GSA Advantage![reg] and Electronic Commerce-FACNET. A request for public comments was..., Washington, DC 20405. Please cite OMB Control No. 3090-00XX, GSA Advantage![reg] and Electronic Commerce...

  5. 77 FR 66464 - Federal Acquisition Regulation; Submission for OMB Review; Value Engineering Requirements

    Science.gov (United States)

    2012-11-05

    ...; whether our estimate of the public burden of this collection of information is accurate, and based on... provided. FOR FURTHER INFORMATION CONTACT: Mr. Curtis E. Glover, Sr., Procurement Analyst, Contract Policy Division, GSA, (202) 501-1448 or email at [email protected] . A. Purpose Per Federal Acquisition...

  6. 77 FR 59790 - General Services Administration Acquisition Regulation (GSAR); Rewrite of Part 504...

    Science.gov (United States)

    2012-10-01

    ... and Forms. This final rule is part of the General Services Administration Acquisition Manual (GSAM... the prescription for inclusion of the clause at 552.204-9, Personal Identity Verification Requirements... the ``National Industrial Security Program Operating Manual (NISPOM)'', and link to the web address...

  7. Getting Back to the Woods: Familial Perspectives on Culture and Preschoolers' Acquisition of Self-Regulation and Emotion Regulation

    Science.gov (United States)

    Boyer, Wanda

    2013-01-01

    Discourse on culture is vital to early childhood educators' understanding of the young child in various socio-cultural experiences in family and community settings. In this article, the author will present a contemporary definition of culture. This article will then discuss the developmental constructs of self-regulation and emotion regulation and…

  8. 77 FR 51867 - Cotton Board Rules and Regulations: Adjusting Supplemental Assessment on Imports

    Science.gov (United States)

    2012-08-28

    ... Advertising, Agricultural research, Cotton, Marketing agreements, Reporting and recordkeeping requirements... supplemental assessments collected for use by the Cotton Research and Promotion Program. An amendment is..., Chief, Research and Promotion Staff, Cotton and Tobacco Programs, AMS, USDA, 100 Riverside Parkway...

  9. Land distribution and acquisition practices in Ghana’s cocoa frontier: The impact of a state-regulated marketing system

    DEFF Research Database (Denmark)

    Knudsen, Michael Helt; Fold, Niels

    2010-01-01

    Substantial differences in the size of landholdings among cocoa farmers in the Western Region – the last cocoa “frontier” in Ghana – are primarily a result of inheritance practices and the purchase of vast tracts of land by migrants in the initial period of the cocoa boom. Individual accumulation...... surplus from their higher volume of cocoa production into investments in non-farm activities and construction of new residential houses—and not in land acquisition based on market transactions. State regulation of the cocoa sector has spurred increased efficiency among private cocoa purchasing companies...

  10. Guidelines on Devising a Programme for Competence Acquisition and Development among Nuclear Regulators

    International Nuclear Information System (INIS)

    2016-12-01

    This publication provides the outline of a programme to strengthen regulatory competences, based on the operating experience of countries with a developed nuclear programme and which are members of the Forum of Radiological and Nuclear Regulatory Agencies (FORO). The guidelines are designed to optimize the resources of the Ibero-American region and they complement and supplement the IAEA’s Safety Reports Series No. 79 as a frame of reference.

  11. Guidelines on Devising a Programme for Competence Acquisition and Development among Nuclear Regulators (Spanish Edition)

    International Nuclear Information System (INIS)

    2016-05-01

    This publication provides the outline of a programme to strengthen regulatory competences, based on the operating experience of countries with a developed nuclear programme and which are members of the Forum of Radiological and Nuclear Regulatory Agencies (FORO). The guidelines are designed to optimize the resources of the Ibero-American region and they complement and supplement the IAEA’s Safety Reports Series No. 79 as a frame of reference.

  12. Review: efficacy of alginate supplementation in relation to appetite regulation and metabolic risk factors: evidence from animal and human studies.

    Science.gov (United States)

    Georg Jensen, M; Pedersen, C; Kristensen, M; Frost, G; Astrup, A

    2013-02-01

    This review provides a critical update on human and animal studies investigating the effect of alginate supplementation on appetite regulation, glycaemic and insulinemic responses, and lipid metabolism with discussion of the evidence on potential mechanisms, efficacy and tolerability. Dependent on vehicle applied for alginate supplementation, the majority of animal and human studies suggest that alginate consumption does suppress satiety and to some extent energy intake. Only one long-term intervention trial found effects on weight loss. In addition, alginates seem to exhibit beneficial influence on postprandial glucose absorption and insulin response in animals and humans. However, alginate supplementation was only found to have cholesterol-lowering properties in animals. Several mechanisms have been suggested for the positive effect observed, which involve delayed gastric emptying, increased viscosity of digesta and slowed nutrient absorption in the small intestine upon alginate gel formation. Despite reasonable efficacy and tolerability from the acute or short-term studies, we still realize there is a critical need for development of optimal alginate types and vehicles as well as studies on further long-term investigation on alginate supplementation in humans before inferring that it could be useful in the management of obesity and the metabolic syndrome. © 2012 The Authors. obesity reviews © 2012 International Association for the Study of Obesity.

  13. 75 FR 38689 - Federal Acquisition Regulation; FAR Case 2009-040, Trade Agreements Thresholds

    Science.gov (United States)

    2010-07-02

    ... (equal exceeding) exceeding) to or exceeding) WTO GPA $203,000 $203,000 $7,804,000 FTAs: Australia FTA 70... 7,804,000 Morocco FTA 203,000 203,000 7,804,000 NAFTA: --Canada 25,000 70,079 9,110,318 --Mexico 70... ``$203,000'' in its place. PART 25--FOREIGN ACQUISITION 25.202 [Amended] 0 3. Amend section 25.202 by...

  14. The Type VI Secretion System Engages a Redox-Regulated Dual-Functional Heme Transporter for Zinc Acquisition.

    Science.gov (United States)

    Si, Meiru; Wang, Yao; Zhang, Bing; Zhao, Chao; Kang, Yiwen; Bai, Haonan; Wei, Dawei; Zhu, Lingfang; Zhang, Lei; Dong, Tao G; Shen, Xihui

    2017-07-25

    The type VI secretion system was recently reported to be involved in zinc acquisition, but the underlying mechanism remains unclear. Here, we report that Burkholderia thailandensis T6SS4 is involved in zinc acquisition via secretion of a zinc-scavenging protein, TseZ, that interacts with the outer membrane heme transporter HmuR. We find that HmuR is a redox-regulated dual-functional transporter that transports heme iron under normal conditions but zinc upon sensing extracellular oxidative stress, triggered by formation of an intramolecular disulfide bond. Acting as the first line of defense against oxidative stress, HmuR not only guarantees an immediate response to the changing environment but also provides a fine-tuned mechanism that allows a gradual response to perceived stress. The T6SS/HmuR-mediated active zinc transport system is also involved in bacterial virulence and contact-independent bacterial competition. We describe a sophisticated bacterial zinc acquisition mechanism affording insights into the role of metal ion transport systems. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  15. NMDA receptor glycine modulatory site in the ventral tegmental area regulates the acquisition, retrieval, and reconsolidation of cocaine reward memory.

    Science.gov (United States)

    Zhou, Shuang-jiang; Xue, Li-fen; Wang, Xue-yi; Jiang, Wen-gao; Xue, Yan-xue; Liu, Jian-feng; He, Yin-yin; Luo, Yi-xiao; Lu, Lin

    2012-05-01

    Accumulating clinical and preclinical studies have shown that the memories of the rewarding effects of drugs and their paired cues may contribute to relapse and persistent cocaine use. Glutaminergic actions in the ventral tegmental area (VTA) have been shown to regulate the rewarding effect of drugs and conditioned responses to drug-associated cues, but the role of the VTA in the acquisition, retrieval, and reconsolidation of cocaine cues is not yet known. In the present study, we used 7-chlorothiokynurenic acid (7-CTKA), an N-methyl-D-aspartate (NMDA) receptor glycine modulatory site antagonist with no rewarding effects, to examine the role of the NMDA receptor glycine modulatory site in the acquisition, retrieval, and reconsolidation of cocaine-related reward memory using the conditioned place preference (CPP) paradigm. Separate groups of Sprague-Dawley rats were trained to acquire cocaine-induced CPP. Vehicle or 7-CTKA was microinjected into the VTA or substantia nigra (SN) (5 μg/μl) at different time points: 10 min before each CPP training session (acquisition), 10 min before the reactivation of CPP (retrieval), and immediately after the reactivation of CPP (reconsolidation). Cocaine-induced CPP was retested 24 h and 1 and 2 weeks after 7-CTKA administration. 7-CTKA microinjected into the VTA, but not SN, significantly impaired the acquisition, retrieval, and reconsolidation of cocaine-induced CPP without affecting cocaine-induced locomotion. Our findings suggest that the NMDA receptor glycine modulatory site in the VTA plays a major role in cocaine reward memory, and NMDA receptor glycine site antagonists may be potential pharmacotherapies for the management of relapse.

  16. Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.

    Science.gov (United States)

    Yakar, Shoshana; Isaksson, Olle

    2016-06-01

    The growth hormone (GH) and its downstream mediator, the insulin-like growth factor-1 (IGF-1), construct a pleotropic axis affecting growth, metabolism, and organ function. Serum levels of GH/IGF-1 rise during pubertal growth and associate with peak bone acquisition, while during aging their levels decline and associate with bone loss. The GH/IGF-1 axis was extensively studied in numerous biological systems including rodent models and cell cultures. Both hormones act in an endocrine and autocrine/paracrine fashion and understanding their distinct and overlapping contributions to skeletal acquisition is still a matter of debate. GH and IGF-1 exert their effects on osteogenic cells via binding to their cognate receptor, leading to activation of an array of genes that mediate cellular differentiation and function. Both hormones interact with other skeletal regulators, such as sex-steroids, thyroid hormone, and parathyroid hormone, to facilitate skeletal growth and metabolism. In this review we summarized several rodent models of the GH/IGF-1 axis and described key experiments that shed new light on the regulation of skeletal growth by the GH/IGF-1 axis. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. 78 FR 5451 - Federal Acquisition Regulation; Submission for OMB Review; Permits, Authorities, or Franchises

    Science.gov (United States)

    2013-01-25

    ...; Submission for OMB Review; Permits, Authorities, or Franchises AGENCIES: Department of Defense (DOD), General... approved information collection requirement concerning permits, authorities, or franchises for regulated..., Permits, Authorities, or Franchises, by any of the following methods: Regulations.gov : http://www...

  18. 77 FR 69442 - Federal Acquisition Regulation; Information Collection; Economic Price Adjustment

    Science.gov (United States)

    2012-11-19

    ...; Information Collection; Economic Price Adjustment AGENCIES: Department of Defense (DOD), General Services... economic price adjustment. Public comments are particularly invited on: Whether this collection of..., Economic Price Adjustment by any of the following methods: Regulations.gov : http://www.regulations.gov...

  19. 77 FR 59613 - General Services Administration Acquisition Regulation (GSAR) Part 523; Submission for OMB Review...

    Science.gov (United States)

    2012-09-28

    ... items of hazardous material allows for appropriate handling of such items throughout GSA's supply chain... 3090- 0205 by any of the following methods: Regulations.gov : http://www.regulations.gov . Submit... customers. Non-Collection and/or a less frequently conducted collection of the information resulting from...

  20. 77 FR 36543 - General Services Administration Acquisition Regulation (GSAR) Part 523; Information Collection...

    Science.gov (United States)

    2012-06-19

    ... handling of such items throughout GSA's supply chain system. The information is used in GSA warehouses, stored in an NSN database and provided to GSA customers. Non-Collection and/or a less frequently... any of the following methods: Regulations.gov : http://www.regulations.gov . Submit comments via the...

  1. 76 FR 35218 - Federal Acquisition Regulation; Information Collection; Cost or Pricing Data Requirements and...

    Science.gov (United States)

    2011-06-16

    ... Pricing Data, by any of the following methods: Regulations.gov : http://www.regulations.gov . Submit...; Information Collection; Cost or Pricing Data Requirements and Information Other Than Cost or Pricing Data... concerning cost or pricing data requirements and information other than cost or pricing data. Public comments...

  2. The System of Public Acquisitions by Means of Electronic Bids in the Light of European Regulations

    Directory of Open Access Journals (Sweden)

    Costantin Roman

    2007-01-01

    Full Text Available E-commerce can lead in many different ways to cost reduction in case of a supplier and can subsequently increase the competition potential of a company. As for the competition mechanism, such changes produce significant modifications within a market economy. The Internet renders the possibility of creating business contacts in a rapid and geographically independent manner, as well as possibilities of obtaining data and realizing transactions within the world’s economy. Public acquisitions by means of dynamic systems and electronic bids are currently one of the significant areas of electronic commerce.

  3. Brief considerations on the acquisition of works of art in the European regulation of public contracts

    Directory of Open Access Journals (Sweden)

    Pierpaolo Forte

    2017-11-01

    Full Text Available The work, renouncing to a precise definition of art, acknowledges that there are art objects and cultural objects, which, in this way, are relevant also in legal terms, and try to advance some reflections on the relevance of art in relation to the European discipline of public contracts and, in particular, what can be deduced from Directive 2014/24 / EU, which can well be understood as a sort of cultural sign that can provide insights into how art is perceived in Europe, even in political terms, in this historical phase. The paper therefore examines the use of negotiated procedures without prior publication of a contract notice, for the «creation or acquisition of a unique work of art or artistic performance», and to do so faces the problem of the object of the procurement by “contracting authorities” which deals with things or performances (works, supplies or services relating to artistic products, by examining the needs which a public administration may have in relation to obtaining the availability of a work of art, and the different modes of this type of acquisition. Finally, the study examines the theme of «art exhibitions», trying to prove that they are autonomous objects, which are represented in the European directive under the diction «artistic performance».

  4. 75 FR 53153 - Federal Acquisition Regulation; American Recovery and Reinvestment Act of 2009 (the Recovery Act...

    Science.gov (United States)

    2010-08-30

    ... States would not fully implement section 1605 of the Recovery Act. Section 1605 singled out iron and... statute and how best to convey these requirements in the regulations. Because iron and steel are singled...

  5. 77 FR 67804 - Federal Acquisition Regulation; Submission for OMB Review; Integrity of Unit Prices

    Science.gov (United States)

    2012-11-14

    ... will be posted without change to http://www.regulations.gov , including any personal and/or business... respond, through the use of appropriate technological collection techniques or other forms of information...

  6. 77 FR 69483 - Federal Acquisition Regulation; Information Collection; Summary Subcontract Report

    Science.gov (United States)

    2012-11-19

    ... be posted without change to http://www.regulations.gov , including any personal and/or business... appropriate technological collection techniques or other forms of information technology. DATES: Submit... small business, small disadvantaged business, historically underutilized business zone (HUBZone) small...

  7. 76 FR 54078 - Cotton Board Rules and Regulations: Adjusting Supplemental Assessment on Imports

    Science.gov (United States)

    2011-08-31

    ... requirements previously approved. List of Subjects in 7 CFR Part 1205 Advertising, Agricultural research... purpose of calculating supplemental assessments collected for use by the Cotton Research and Promotion...: Effective Date: September 30, 2011. FOR FURTHER INFORMATION CONTACT: Shethir M. Riva, Chief, Research and...

  8. The Effect of Concrete Supplements on Metacognitive Regulation during Learning and Open-Book Test Taking

    Science.gov (United States)

    Ackerman, Rakefet; Leiser, David

    2014-01-01

    Background: Previous studies have suggested that when reading texts, lower achievers are more sensitive than their stronger counterparts to surface-level cues, such as graphic illustrations, and that even when uninformative, such concrete supplements tend to raise the text's subjective comprehensibility. Aims: We examined how being led astray…

  9. Garlic Supplementation Ameliorates UV-Induced Photoaging in Hairless Mice by Regulating Antioxidative Activity and MMPs Expression.

    Science.gov (United States)

    Kim, Hye Kyung

    2016-01-08

    UV exposure is associated with oxidative stress and is the primary factor in skin photoaging. UV-induced reactive oxygen species (ROS) cause the up-regulation of metalloproteinase (MMPs) and the degradation of dermal collagen and elastic fibers. Garlic and its components have been reported to exert antioxidative effects. The present study investigated the protective effect of garlic on UV-induced photoaging and MMPs regulation in hairless mice. Garlic was supplemented in the diet, and Skh-1 hairless mice were exposed to UV irradiation five days/week for eight weeks. Mice were divided into four groups; Non-UV, UV-irradiated control, UV+1% garlic powder diet group, and UV+2% garlic powder diet group. Chronic UV irradiation induced rough wrinkling of the skin with hyperkeratosis, and administration of garlic diminished the coarse wrinkle formation. UV-induced dorsal skin and epidermal thickness were also ameliorated by garlic supplementation. ROS generation, skin and serum malondialdehyde levels were significantly increased by UV exposure and were ameliorated by garlic administration although the effects were not dose-dependent. Antioxidant enzymes such as superoxide dismutase and catalase activities in skin tissues were markedly reduced by UV irradiation and garlic treatment increased these enzyme activities. UV-induced MMP-1 and MMP-2 protein levels were suppressed by garlic administration. Furthermore, garlic supplementation prevented the UV-induced increase of MMP-1 mRNA expression and the UV-induced decrease of procollagen mRNA expression. These results suggest that garlic may be effective for preventing skin photoaging accelerated by UV irradiation through the antioxidative system and MMP regulation.

  10. Positive muscle protein net balance and differential regulation of atrogene expression after resistance exercise and milk protein supplementation

    DEFF Research Database (Denmark)

    Reitelseder, Søren; Agergaard, Jakob; Doessing, Simon

    2014-01-01

    Purpose Resistance exercise and amino acid availability are positive regulators of muscle protein net balance (NB). However, anabolic responses to resistance exercise and protein supplementation deserve further elucidation. The purpose was to compare intakes of whey, caseinate (both: 0.30 g/kg lean...... body mass), or a non-caloric control after heavy resistance exercise on protein turnover and mRNA expressions of forkhead homeobox type O (FOXO) isoforms, muscle RING finger 1 (MuRF1), and Atrogin1 in young healthy males. Methods Protein turnover was determined by stable isotope-labeled leucine...

  11. 78 FR 18342 - Federal Acquisition Regulation; Submission for OMB Review; Change Order Accounting

    Science.gov (United States)

    2013-03-26

    ...; Submission for OMB Review; Change Order Accounting AGENCY: Department of Defense (DOD), General Services... requirement concerning change order accounting. A notice was published in the Federal Register at 77 FR 51804... Collection 9000- 0026, Change Order Accounting, by any of the following methods: Regulations.gov : http://www...

  12. 77 FR 51804 - Federal Acquisition Regulation; Information Collection; Change Order Accounting

    Science.gov (United States)

    2012-08-27

    ...; Information Collection; Change Order Accounting AGENCY: Department of Defense (DOD), General Services... requirement concerning change order accounting. Public comments are particularly invited on: Whether this... 9000- 0026, Change Order Accounting by any of the following methods: Regulations.gov : http://www...

  13. 77 FR 27547 - Federal Acquisition Regulation; Prohibition on Contracting With Inverted Domestic Corporations

    Science.gov (United States)

    2012-05-10

    ... concerns are unlikely to have been incorporated in the United States and then reincorporated in a tax haven... assess all costs and benefits of available regulatory alternatives and, if regulation is necessary, to select regulatory approaches that maximize net benefits (including potential economic, environmental...

  14. 76 FR 60048 - Federal Acquisition Regulation; Submission for OMB Review; Trade Agreements Certificate

    Science.gov (United States)

    2011-09-28

    ... submitting to the Office of Management and Budget (OMB) a request to review and approve an extension of a... posted without change to http://www.regulations.gov , including any personal and/or business confidential... products. Items having components of unknown origin are considered to have been mined, produced, or...

  15. 77 FR 66844 - Federal Acquisition Regulation; Submission for OMB Review; Evaluation of Export Offers

    Science.gov (United States)

    2012-11-07

    ... Management and Budget (OMB) a request to review and approve an extension of a previously approved information... posted without change to http://www.regulations.gov , including any personal and/or business confidential... United States (CONUS) ports and offers are solicited on a free onboard (f.o.b.) origin or f.o.b...

  16. 75 FR 26916 - Federal Acquisition Regulation: FAR Case 2009-004, Enhancing Contract Transparency

    Science.gov (United States)

    2010-05-13

    ... Regulation: FAR Case 2009-004, Enhancing Contract Transparency AGENCY: Department of Defense (DoD), General... commercial or financial information. This transparency effort is intended to promote efficiency in Government... the Administration's memorandum entitled Transparency and Open Government (January 21, 2009...

  17. 75 FR 53269 - Federal Acquisition Regulation; Tribal Consultation; Justification and Approval of Sole-Source 8...

    Science.gov (United States)

    2010-08-31

    ... and approval of sole-source contracts over $20 million under the 8(a) small business development... valuable component of its deliberations in preparing to implement this law, which includes contracting with... Regulation; Tribal Consultation; Justification and Approval of Sole-Source 8(a) Contracts AGENCIES...

  18. Constructive, Self-Regulated, Situated, and Collaborative Learning: An Approach for the Acquisition of Adaptive Competence

    Science.gov (United States)

    de Corte, Erik

    2012-01-01

    In today's learning society, education must focus on fostering adaptive competence (AC) defined as the ability to apply knowledge and skills flexibly in different contexts. In this article, four major types of learning are discussed--constructive, self-regulated, situated, and collaborative--in relation to what students must learn in order to…

  19. 78 FR 48123 - Federal Acquisition Regulation; Contractor Comment Period, Past Performance Evaluations

    Science.gov (United States)

    2013-08-07

    ....regulations.gov , including any personal and/or business confidential information provided. FOR FURTHER... equivalent of ``providing'' the past performance evaluation to the contractor, and it starts the suspense... explanations included, available to source selection officials within 14 days will be to the advantage of most...

  20. 78 FR 18346 - Federal Acquisition Regulation; Submission for OMB Review; Use of Data Universal Numbering System...

    Science.gov (United States)

    2013-03-26

    ... will be posted without change to http://www.regulations.gov , including any personal and/or business..., processes, and disseminates official statistical data on Federal contracting. Contracting officers insert... respondent commented that the extension of the information collection would violate the fundamental purposes...

  1. 77 FR 29982 - Federal Acquisition Regulation; Submission for OMB Review; Davis Bacon Act-Price Adjustment...

    Science.gov (United States)

    2012-05-21

    ...; Submission for OMB Review; Davis Bacon Act-Price Adjustment (Actual Method) AGENCY: Department of Defense... previously approved information collection requirement concerning the Davis-Bacon Act price adjustment... Bacon Act-Price Adjustment (Actual Method), by any of the following methods: Regulations.gov : http...

  2. 77 FR 50631 - Homeland Security Acquisition Regulation (HSAR); Revision Initiative [HSAR Case 2009-002

    Science.gov (United States)

    2012-08-22

    ..., provides guidance and direction for compliance with green purchasing and other sustainable practices...--IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST 0 14. Revise section 3003.101-3 to read as follows: 3003.101-3 Agency regulations. The United States Office of Government Ethics has promulgated...

  3. 75 FR 3236 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2010-01-20

    ... extension of a previously approved information collection requirement concerning cost accounting standards... include pertinent rules and regulations related to the Cost Accounting Standards along with necessary... impact estimates and descriptions in cost accounting practices and also to provide information on CAS...

  4. 78 FR 13675 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Science.gov (United States)

    2013-02-28

    ...; Submission for OMB Review; Cost Accounting Standards Administration AGENCY: Department of Defense (DOD... collection requirement concerning cost accounting standards administration. A notice was published in the...- 0129, Cost Accounting Standards Administration by any of the following methods: Regulations.gov : http...

  5. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Science.gov (United States)

    2010-04-01

    ... not using, such method of regulated accounting only with respect to property subject to the... treatment of certain property as “pre-1970 public utility property” and § 1.167(l)-1(e)(4)(ii) for...) Property not entirely subject to jurisdiction of one regulatory body—(1) In general. If a taxpayer which...

  6. 77 FR 43076 - Federal Acquisition Regulation; Information Collection; Value Engineering Requirements

    Science.gov (United States)

    2012-07-23

    ... respond, through the use of appropriate technological collection techniques or other forms of information... collection. All comments received will be posted without change to http://www.regulations.gov , including any personal and/or business confidential information provided. FOR FURTHER INFORMATION CONTACT: Mr. Curtis E...

  7. 77 FR 69626 - Federal Acquisition Regulation; Information Collection; Subcontracting Plans/Individual...

    Science.gov (United States)

    2012-11-20

    ... collection of information on those who are to respond, through the use of appropriate technological... this collection. All comments received will be posted without change to http://www.regulations.gov , including any personal and/or business confidential information provided. FOR FURTHER INFORMATION CONTACT...

  8. Improvement The Acquisition of Research Methodology and Self Regulated Learning through Blog Project

    Directory of Open Access Journals (Sweden)

    Heri Retnawati

    2017-06-01

    Full Text Available Abstract: This classroom action research seeks to improveself-regulated learning (SRL and understanding of research methodology at the graduate school. Nineteen graduate school students were involved. Using project-based learning (PjBL, students were assigned to create online blogs as the main project. The blog was intended for representing their understanding of research methodology by writing review of research articles and submitting a research proposal. The classroom action research was based ona model by Kemmis & McTaggart and was conducted in two cycles. The data were analyzed using mixed methods in which the main data were analyzed qualitatively and further analysed quantitatively. The results of the study showed that after completing the course, students not only gained knowledge about research methods, but were also able to write are search proposal. In addition, the project-based learning could facilitate students to practice their communication skills while writing on their blog and to improve selfegulated learning. Keywords: Action research, project-based learning, blog, self-regulated learning PENINGKATAN PENGUASAAN METODOLOGI PENELITIAN DAN SELF REGULATED LEARNING MELALUI PROJEK BLOG Abstrak: Penelitian tindakan kelas ini bertujuan untuk meningkatkan kemandirian belajar dan pemahaman metodologi penelitian di sekolah Pascasarjana. Partisipan yang terlibat pada studi ini adalah 19 mahasiswa master di sekolah pascasarjana. Dengan menerapkan pembelajaran berbasis projek (PjBL, mahasiswa diberi tugas membuat blog sebagai projek utama. Projek yang dibuat mahasiswa berupa blog untuk merepresantasikan pemahaman metodologi penelitian mahasiswa melalui tulisan dan usulan penelitian tesis. Penelitian tindakan ini dilaksanakan dalam dua siklus dengan model Kemmis & Taggart. Analisis data dilakukan dengan mixed methods secara kualitatif dengan dilengkapi analisis kuantitatif sebagai pendukung. Hasil studi menunjukkan bahwa setelah menyelesaikan

  9. Nitrogen regulation of transpiration controls mass-flow acquisition of nutrients.

    Science.gov (United States)

    Matimati, Ignatious; Verboom, G Anthony; Cramer, Michael D

    2014-01-01

    Transpiration may enhance mass-flow of nutrients to roots, especially in low-nutrient soils or where the root system is not extensively developed. Previous work suggested that nitrogen (N) may regulate mass-flow of nutrients. Experiments were conducted to determine whether N regulates water fluxes, and whether this regulation has a functional role in controlling the mass-flow of nutrients to roots. Phaseolus vulgaris were grown in troughs designed to create an N availability gradient by restricting roots from intercepting a slow-release N source, which was placed at one of six distances behind a 25 μm mesh from which nutrients could move by diffusion or mass-flow (termed 'mass-flow' treatment). Control plants had the N source supplied directly to their root zone so that N was available through interception, mass-flow, and diffusion (termed 'interception' treatment). 'Mass-flow' plants closest to the N source exhibited 2.9-fold higher transpiration (E), 2.6-fold higher stomatal conductance (gs), 1.2-fold higher intercellular [CO2] (Ci), and 3.4-fold lower water use efficiency than 'interception' plants, despite comparable values of photosynthetic rate (A). E, gs, and Ci first increased and then decreased with increasing distance from the N source to values even lower than those of 'interception' plants. 'Mass-flow' plants accumulated phosphorus and potassium, and had maximum concentrations at 10mm from the N source. Overall, N availability regulated transpiration-driven mass-flow of nutrients from substrate zones that were inaccessible to roots. Thus when water is available, mass-flow may partially substitute for root density in providing access to nutrients without incurring the costs of root extension, although the efficacy of mass-flow also depends on soil nutrient retention and hydraulic properties.

  10. 76 FR 36508 - Migratory Bird Hunting; Supplemental Proposals for Migratory Game Bird Hunting Regulations for...

    Science.gov (United States)

    2011-06-22

    ..., Newport, RI. Mississippi Flyway Council: July 22-23, Crowne Plaza, Little Rock, AR. Central Flyway Council... with two splits or four zones) for use during the 2011-12 regulations cycle season (see the April 8... configurations through the 2012 regulations cycle. The Central and Pacific Flyway Councils recommended extending...

  11. Regulation of “Banking Group” In Russia in Banking Mergers and Acquisitions in the Modern Conditions

    Directory of Open Access Journals (Sweden)

    Nikita V. Gurin

    2016-01-01

    research the author suggests legal developments to the regulations of mergers and acquisitions of banks in Russia.

  12. 77 FR 52258 - Defense Federal Acquisition Regulation Supplement; DoD Voucher Processing (DFARS Case 2011-D054)

    Science.gov (United States)

    2012-08-29

    ... after a pre-payment review. Interim vouchers not selected for a pre-payment review will be considered to... a pre- payment review. Interim vouchers not selected for a pre-payment review will be considered to... office after a pre-payment review. Interim vouchers not selected for a pre-payment review will be...

  13. 77 FR 9617 - Defense Federal Acquisition Regulation Supplement; DoD Voucher Processing (DFARS Case 2011-D054)

    Science.gov (United States)

    2012-02-17

    ... provisional payment and sent to the disbursing office after the pre-payment review. Interim vouchers not... evaluation of selected interim vouchers on a pre-payment basis in lieu of the current direct submission authorization, which does not allow for the pre-payment evaluation of higher risk interim vouchers. It is...

  14. 76 FR 71928 - Defense Federal Acquisition Regulation Supplement; Updates to Wide Area WorkFlow (DFARS Case 2011...

    Science.gov (United States)

    2011-11-21

    ...'' under the heading ``Enter keyword or ID'' and selecting ``Search.'' Select the link ``Submit a Comment... the introductory text to remove ``232.7004'' and insert in its place ``232.7004(a)''; (b) Amending the... payment requests through WAWF. Both can be accessed by selecting the ``Web Based Training'' link on the...

  15. 77 FR 4638 - Defense Federal Acquisition Regulation Supplement; Performance-Based Payments (DFARS Case 2011-D045)

    Science.gov (United States)

    2012-01-30

    ... tool. The PBP analysis tool is a cash-flow model for evaluating alternative financing arrangements, and..., public health and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance... PBP analysis tool is a cash-flow model for evaluating alternative financing arrangements, and is...

  16. 76 FR 58137 - Defense Federal Acquisition Regulation Supplement; Positive Law Codification of Title 41 U.S.C...

    Science.gov (United States)

    2011-09-20

    ... impacts, and equity). Executive Order 13563 emphasizes the importance of quantifying both costs and... FINANCING 232.803 [Amended] 0 8. Amend section 232.803(d) by removing ``Section 3737(e) of the Revised...

  17. 76 FR 8303 - Defense Federal Acquisition Regulation Supplement; Award-Fee Contracts (DFARS Case 2006-D021)

    Science.gov (United States)

    2011-02-14

    ... event a contractor fails to meet contractual obligations. Assuming the contract is properly structured... meet contractual performance requirements will maximize the amount of award fee earned, there is no...

  18. 75 FR 34943 - Defense Federal Acquisition Regulation Supplement; Para-Aramid Fibers and Yarns Manufactured in a...

    Science.gov (United States)

    2010-06-21

    ... well-being of the textile industry, including knitters, weavers, finishers, and garment makers, is....S. Response: DoD concurs. The request from industry that precipitated the USD (AT&L)'s determination... respondent was concerned about negative impact on spinners, knitters, weavers, finishers, and garment makers...

  19. 78 FR 30231 - Defense Federal Acquisition Regulation Supplement: Clarification of “F” Orders in the Procurement...

    Science.gov (United States)

    2013-05-22

    ... supplementary procurement instrument identification numbers. DATES: Effective: May 22, 2013. FOR FURTHER... the use of ``F'' in the 9th position of the PIIN to those orders and calls issued by DoD under... by an ``F'' in the 9th position of the PIIN, field activities would no longer be able to pull data...

  20. The Acquisition and Valuation of Goodwill: a Comparison of the Regulations of Albania and the IFRS

    Directory of Open Access Journals (Sweden)

    Mustafa ÜÇ

    2016-07-01

    Full Text Available This study examines whether there are differences in accounting of goodwill among IFRS, SKK (Albanian Accounting Standards which it is an adoption of IFRS and Albanian tax regulations. The study first presents general theory of intangible assets. This is followed by an elaborate explanation of goodwill which includes a deeper discussion about estimation and valuation and accounting treatment of goodwill. The accounting treatment of goodwill regarding to IFRS and local regulations is analyzed by a real case of purchased goodwill of Albtelecom Sh.A, a telecommunication company which provides fix telephony and internet service. The results of the case study indicate differences between IFRS and Albanian tax legislation in accounting treatment of goodwill, while between IFRS 3 and SKK 9 there is not any difference. According to both standards, goodwill is recognized by purchase method and it is subject to annual impairment test. However, instruction "On Income Tax" requires that, intangible assets such as purchased goodwill, amortized at a rate to allow for the fiscal effect of 15% which is applied on historical costs which may be added the costs of upgrading and renewal of the assets.

  1. Small Molecule Supplements Improve Cultured Megakaryocyte Polyploidization by Modulating Multiple Cell Cycle Regulators.

    Science.gov (United States)

    Zou, Xiaojing; Qu, Mingyi; Fang, Fang; Fan, Zeng; Chen, Lin; Yue, Wen; Xie, Xiaoyan; Pei, Xuetao

    2017-01-01

    Platelets (PLTs) are produced by megakaryocytes (MKs) that completed differentiation and endomitosis. Endomitosis is an important process in which the cell replicates its DNA without cytokinesis and develops highly polyploid MK. In this study, to gain a better PLTs production, four small molecules (Rho-Rock inhibitor (RRI), nicotinamide (NIC), Src inhibitor (SI), and Aurora B inhibitor (ABI)) and their combinations were surveyed as MK culture supplements for promoting polyploidization. Three leukemia cell lines as well as primary mononuclear cells were chosen in the function and mechanism studies of the small molecules. In an optimal culture method, cells were treated with different small molecules and their combinations. The impact of the small molecules on megakaryocytic surface marker expression, polyploidy, proliferation, and apoptosis was examined for the best MK polyploidization supplement. The elaborate analysis confirmed that the combination of SI and RRI together with our MK induction system might result in efficient ploidy promotion. Our experiments demonstrated that, besides direct downregulation on the expression of cytoskeleton protein actin, SI and RRI could significantly enhance the level of cyclins through the suppression of p53 and p21. The verified small molecule combination might be further used in the in vitro PLT manufacture and clinical applications.

  2. Small Molecule Supplements Improve Cultured Megakaryocyte Polyploidization by Modulating Multiple Cell Cycle Regulators

    Directory of Open Access Journals (Sweden)

    Xiaojing Zou

    2017-01-01

    Full Text Available Platelets (PLTs are produced by megakaryocytes (MKs that completed differentiation and endomitosis. Endomitosis is an important process in which the cell replicates its DNA without cytokinesis and develops highly polyploid MK. In this study, to gain a better PLTs production, four small molecules (Rho-Rock inhibitor (RRI, nicotinamide (NIC, Src inhibitor (SI, and Aurora B inhibitor (ABI and their combinations were surveyed as MK culture supplements for promoting polyploidization. Three leukemia cell lines as well as primary mononuclear cells were chosen in the function and mechanism studies of the small molecules. In an optimal culture method, cells were treated with different small molecules and their combinations. The impact of the small molecules on megakaryocytic surface marker expression, polyploidy, proliferation, and apoptosis was examined for the best MK polyploidization supplement. The elaborate analysis confirmed that the combination of SI and RRI together with our MK induction system might result in efficient ploidy promotion. Our experiments demonstrated that, besides direct downregulation on the expression of cytoskeleton protein actin, SI and RRI could significantly enhance the level of cyclins through the suppression of p53 and p21. The verified small molecule combination might be further used in the in vitro PLT manufacture and clinical applications.

  3. Hyaluronan supplementation as a mechanical regulator of cartilage tissue development under joint-kinematic-mimicking loading.

    Science.gov (United States)

    Wu, Yabin; Stoddart, Martin J; Wuertz-Kozak, Karin; Grad, Sibylle; Alini, Mauro; Ferguson, Stephen J

    2017-08-01

    Articular cartilage plays an essential role in joint lubrication and impact absorption. Through this, the mechanical signals are coupled to the tissue's physiological response. Healthy synovial fluid has been shown to reduce and homogenize the shear stress acting on the cartilage surfaces due to its unique shear-thinning viscosity. As cartilage tissues are sensitive to mechanical changes in articulation, it was hypothesized that replacing the traditional culture medium with a healthy non-Newtonian lubricant could enhance tissue development in a cartilage engineering model, where joint-kinematic-mimicking mechanical loading is applied. Different amounts of hyaluronic acid were added to the culture medium to replicate the viscosities of synovial fluid at different health states. Hyaluronic acid supplementation, especially at a physiologically healthy concentration (2.0 mg ml -1 ), promoted a better preservation of chondrocyte phenotype. The ratio of collagen II to collagen I mRNA was 4.5 times that of the control group, implying better tissue development (however, with no significant difference of measured collagen II content), with a good retention of collagen II and proteoglycan in the mechanically active region. Simulating synovial fluid properties by hyaluronic acid supplementation created a favourable mechanical environment for mechanically loaded constructs. These findings may help in understanding the influence of joint articulation on tissue homeostasis, and moreover, improve methods for functional cartilage tissue engineering. © 2017 The Author(s).

  4. Federal Act on Protection against Nuisances (BImSchG) and supplementing regulations. 11. ed.

    International Nuclear Information System (INIS)

    Hansmann, K.

    1993-01-01

    This handy booklet contains the BImSchG and related implementing regulations as well as the Technical Codes Clean Air and Noise Abatement. The contribution on the BImSchG explains the origin of the Act, the scope of application, its concept and principles. The contents of the Act is portrayed by emphasizing subject-related connections. Dealt with are also regulations for installations requiring licensing, the measurement of airborne pollution, stipulations concerning the area of installations and transport, as well as the regulation concerning the monitoring of airborne pollution in the Federal Republic of Germany. (orig.) [de

  5. Federal Act on Protection against Nuisances (BImSchG) and supplementing regulations. 9. ed.

    International Nuclear Information System (INIS)

    Hansmann, K.

    1992-01-01

    This handy booklet contains the BImSchG and related implementing regulations as well as the Technical Codes Clean Air and Noise Abatement. The contribution on the BImSchG explains the origin of the Act, the scope of application, its concept and principles. The contents of the Act is portrayed by emphasizing subject-related connections. Dealt with are also regulations for installations requiring licensing, the measurement of airborne pollution, stipulations concerning the area of installations and transport, as well as the regulation concerning the monitoring of airborne pollution in the Federal Republic of Germany. (orig.) [de

  6. Chromatographic fingerprinting as a strategy to identify regulated plants in illegal herbal supplements.

    Science.gov (United States)

    Custers, D; Van Praag, N; Courselle, P; Apers, S; Deconinck, E

    2017-03-01

    Erectile dysfunction (ED) is a sexual disorder characterized by the inability to achieve or maintain a sufficiently rigid erection. Despite the availability of non-invasive oral treatment options, many patients turn to herbal alternatives. Furthermore, herbal supplements are increasingly gaining popularity in industrialized countries and, as a consequence, quality control is a highly important issue. Unfortunately, this is not a simple task since plants are often crushed and mixed with other plants, which complicates their identification by usage of classical approaches such as microscopy. The aim of this study was to explore the potential use of chromatographic fingerprinting to identify plants present in herbal preparations intended for the treatment of ED. To achieve this goal, a HPLC-PDA and a HPLC-MS method were developed, using a full factorial experimental design in order to acquire characteristic fingerprints of three plants which are potentially beneficial for treating ED: Epimedium spp., Pausinystalia yohimbe and Tribulus terrestris. The full factorial design demonstrated that for all three plant references a C8 column (250mm×4.6mm; 5µm particle size) is best suited; methanol and an ammonium formate buffer (pH 3) were found to be the best constituents for the mobile phase. The suitability of this strategy was demonstrated by analysing several self-made triturations in three different botanical matrices, which mimic the influential effects that could be expected when analysing herbal supplements. To conclude, this study demonstrates that chromatographic fingerprinting could provide a useful means to identify plants in a complex herbal mixture. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. 78 FR 32686 - Final Supplemental Environmental Impact Statement on the Issuance of Annual Regulations...

    Science.gov (United States)

    2013-05-31

    ... special regulations. (5) Management scale for the harvest of migratory birds. We define management scale... comments in revising the document. The SEIS analyzes a range of management alternatives for addressing the... Representative, Division of Migratory Bird Management, (503) 231-6162; or Brad Bortner, Chief, Division of...

  8. 78 FR 35844 - Migratory Bird Hunting; Supplemental Proposals for Migratory Game Bird Hunting Regulations for...

    Science.gov (United States)

    2013-06-14

    ..., Puerto Rico, and the Virgin Islands. The Committee will also develop regulations recommendations for September waterfowl seasons in designated States, special sea duck seasons in the Atlantic Flyway, and... usually commence at 8 a.m. on the days indicated. Atlantic Flyway Council: July 18-19, Mystic Hilton...

  9. Excited, Proud, and Accomplished: Exploring the Effects of Feedback Supplemented with Web-Based Peer Benchmarking on Self-Regulated Learning in Marketing Classrooms

    Science.gov (United States)

    Raska, David

    2014-01-01

    This research explores and tests the effect of an innovative performance feedback practice--feedback supplemented with web-based peer benchmarking--through a lens of social cognitive framework for self-regulated learning. The results suggest that providing performance feedback with references to exemplary peer output is positively associated with…

  10. Regulation of carnitine status in ruminants and efficacy of carnitine supplementation on performance and health aspects of ruminant livestock: a review.

    Science.gov (United States)

    Ringseis, Robert; Keller, Janine; Eder, Klaus

    2018-02-01

    Carnitine has long been known to play a critical role for energy metabolism. Due to this, a large number of studies have been carried out to investigate the potential of supplemental carnitine in improving performance of livestock animals including ruminants, with however largely inconsistent results. An important issue that has to be considered when using carnitine as a feed additive is that the efficacy of supplemental carnitine is probably dependent on the animal's carnitine status, which is affected by endogenous carnitine synthesis, carnitine uptake from the gastrointestinal tract and carnitine excretion. The present review aims to summarise the current knowledge of the regulation of carnitine status and carnitine homeostasis in ruminants, and comprehensively evaluate the efficacy of carnitine supplementation on performance and/or health in ruminant livestock by comparing the outcomes of studies with carnitine supplementation in dairy cattle, growing and finishing cattle and sheep. While most of the studies show that supplemental carnitine, even in ruminally unprotected form, is bioavailable in ruminants, its effect on either milk or growth performance is largely disappointing. However, supplemental carnitine appears to be a useful strategy to offer protection against ammonia toxicity caused by consumption of high levels of non-protein N or forages with high levels of soluble N both, in cattle and sheep.

  11. 48 CFR 873.105 - Acquisition planning.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquisition planning. 873.105 Section 873.105 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS DEPARTMENT... planning. (a) Acquisition planning is an indispensable component of the total acquisition process. (b) For...

  12. 48 CFR 3034.004 - Acquisition strategy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Acquisition strategy. 3034.004 Section 3034.004 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND... Acquisition strategy. See (HSAR) 48 CFR 3009.570 for policy applicable to acquisition strategies that consider...

  13. 48 CFR 434.004 - Acquisition strategy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Acquisition strategy. 434.004 Section 434.004 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION General 434.004 Acquisition strategy. (a) The program...

  14. 75 FR 34279 - Federal Acquisition Regulation; FAR Case 2009-011, American Recovery and Reinvestment Act of 2009...

    Science.gov (United States)

    2010-06-16

    ... criminal or civil penalties, or if the Federal Acquisition Regulatory Council (FARC) makes a written... contractor and subcontractor records, the FARC has determined that this rule should apply to contracts or...

  15. The Regulation and Expression of the Creatine Transporter: A Brief Review of Creatine Supplementation in Humans and Animals

    OpenAIRE

    Schoch, Ryan D; Willoughby, Darryn; Greenwood, Mike

    2006-01-01

    Abstract Creatine monohydrate has become one of the most popular ergogenic sport supplements used today. It is a nonessential dietary compound that is both endogenously synthesized and naturally ingested through diet. Creatine ingested through supplementation has been observed to be absorbed into the muscle exclusively by means of a creatine transporter, CreaT1. The major rationale of creatine supplementation is to maximize the increase within the intracellular pool of total creatine (creatin...

  16. Differences in academic performance and self-regulated learning based on level of student participation in supplemental instruction

    Science.gov (United States)

    Mack, Ana C.

    This study examined differences in academic performance and self-regulated learning based on levels of student participation in Supplemental Instruction (SI) sessions in two introductory undergraduate biology and chemistry courses offered at University of Central Florida in the Spring 2006 semester. The sample consisted of 282 students enrolled in the biology class and 451 students enrolled in chemistry. Academic performance was measured using students' final course grades and rates of withdrawal from the courses. The self-regulated learning constructs of motivation, cognition, metacognition, and resource management were measured using the Motivated Strategies for Learning Questionnaire (MSLQ). Relationships between students' gender and ethnic background and levels of SI participation were also analyzed in this research. Findings in both biology and chemistry courses revealed a statistically significant decrease in student motivation from beginning to end of semester. In chemistry, frequent SI participants also showed statistically significantly higher levels of motivation at the end of the semester than occasional and non-SI participants. There were no statistically significant gains in cognitive, metacognitive, and resource management strategies from beginning to end of semester. However, statistically significant differences in resource management were observed at the end of the semester among SI attendance groups in both courses. Students in the high SI attendance group were more likely to use learning resources than those who did not participate regularly or did not participate at all. Statistically significant differences in academic performance based on students' SI participation were found in both biology and chemistry courses. Frequent SI participants had significantly higher final percentage grades and were more likely to receive grades of A, B, or C, than those who either did not attend SI regularly of did not participate at all. They were also less

  17. 48 CFR 32.003 - Simplified acquisition procedures financing.

    Science.gov (United States)

    2010-10-01

    ... procedures financing. 32.003 Section 32.003 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING 32.003 Simplified acquisition procedures financing. Unless agency regulations otherwise permit, contract financing shall not be provided for...

  18. 48 CFR 1845.407 - Non-Government use of plant equipment. (NASA supplements paragraph (a)).

    Science.gov (United States)

    2010-10-01

    ... Use and Rental of Government Property 1845.407 Non-Government use of plant equipment. (NASA supplements paragraph (a)). For NASA, the coverage in FAR 45.407, applies to all equipment, not just plant... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Non-Government use of plant...

  19. An overview of herb and dietary supplement efficacy, safety and government regulations in the United States with suggested improvements. Part 1 of 5 series.

    Science.gov (United States)

    Brown, Amy Christine

    2017-09-01

    This is the first of five review articles investigating dietary supplements (DS; includes herbs) that now exceed over 50,000 in the Office of Dietary Supplement's "Dietary Supplement Label Database." Four review articles follow summarizing published medical case reports of DS related to liver toxicity, kidney toxicity, heart toxicity, and cancer. The most popular DS were vitamin or mineral supplements (43%) followed by specialty supplements (20%), botanicals (20%; herbs), and sports supplements (16%). The 2013 Annual Report of the American Association of Poison Control Centers revealed 1692 fatalities due to drugs, and zero deaths due to DS. Less than 1 percent of Americans experience adverse events related to DS, and the majority was classified as minor, with many of these related to caffeine, yohimbe, or other stimulant ingredients. The number one adulterant in DS is drugs, followed by New Dietary Ingredients (NDI) not submitted to the FDA - both are illegal and not DS, but rather "tainted products marketed as dietary supplements." The three main categories of DS prone to medical problems are those for sexual enhancement, weight loss, and sports performance/body building. DS are regulated in the U.S. by several federal agencies with overlapping jurisdiction - the Food and Drug Administration (FDA) and the Federal Trade Commission (FTC); enforced by the State Attorneys General Offices (AGO) and Department of Justice (DOJ); and monitored (not regulated) by the Centers for Disease Control and Prevention (CDC). The FDA can remove a DS from the market for phase IV post-marketing surveillance adverse event reports, adulteration (drugs, NDI, synthetic substances), contamination, misidentification, mislabeling or false claims, and not meeting good manufacturing practices (GMP). The FTC and state AGO can also enforce laws against deceptive marketing practices. Suggested improvements to current regulatory requirements are included along with online DS Toxic Tables in the

  20. Short term supplementation of dietary antioxidants selectively regulates the inflammatory responses during early cutaneous wound healing in diabetic mice

    Directory of Open Access Journals (Sweden)

    Park Na-Young

    2011-11-01

    Full Text Available Abstract Background Diabetic foot ulcers are serious complications for diabetic patients, yet the precise mechanism that underlines the treatment of these diabetic complications remains unclear. We hypothesized that dietary antioxidant supplementation with vitamin C, combined either with vitamin E or with vitamin E and NAC, improves delayed wound healing through modulation of blood glucose levels, oxidative stress, and inflammatory response. Methods Diabetes was induced by administration of alloxan monohydrate. Mice were divided into 4 groups; CON (non-diabetic control mice fed AIN 93 G purified rodent diet, DM (diabetic mice fed AIN 93 G purified rodent diet, VCE (diabetic mice fed 0.5% vitamin C and 0.5% vitamin E supplemented diet, and Comb (diabetic mice fed 0.5% vitamin C, 0.5% vitamin E, and 2.5% NAC supplemented diet. After 10 days of dietary antioxidant supplementation, cutaneous full-thickness excisional wounds were performed, and the rate of wound closure was examined. TBARS as lipid peroxidation products and vitamin E levels were measured in the liver. Expression levels of oxidative stress and inflammatory response related proteins were measured in the cutaneous wound site. Results Dietary antioxidant supplementation improved blood glucose levels and wound closure rate and increased liver vitamin E, but not liver TBARS levels in the diabetic mice as compared to those of the CON. In addition, dietary antioxidant supplementation modulated the expression levels of pIκBα, HO-1, CuZnSOD, iNOS and COX-2 proteins in the diabetic mice. Conclusions These findings demonstrated that delayed wound healing is associated with an inflammatory response induced by hyperglycaemia, and suggests that dietary antioxidant supplementation may have beneficial effects on wound healing through selective modulation of blood glucose levels, oxidative stress, and inflammatory response.

  1. 48 CFR 34.004 - Acquisition strategy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition strategy. 34... CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION General 34.004 Acquisition strategy. The program manager, as specified in agency procedures, shall develop an acquisition strategy tailored to the particular...

  2. 48 CFR 234.004 - Acquisition strategy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Acquisition strategy. 234..., DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION 234.004 Acquisition strategy. (1) See 209.570 for policy applicable to acquisition strategies that consider the use of lead system...

  3. 48 CFR 970.2301 - Sustainable acquisition.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Sustainable acquisition. 970.2301 Section 970.2301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY..., Renewable Energy Technologies, Occupational Safety and Drug-Free Work Place 970.2301 Sustainable acquisition...

  4. Sports Supplements

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Sports Supplements KidsHealth / For Teens / Sports Supplements What's in ... really work? And are they safe? What Are Sports Supplements? Sports supplements (also called ergogenic aids ) are ...

  5. 48 CFR 307.104-70 - Acquisition strategy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Acquisition strategy. 307... AND ACQUISITION PLANNING ACQUISITION PLANNING Acquisition Planning 307.104-70 Acquisition strategy... designated by the HHS CIO, DASFMP, the CAO, or the cognizant HCA) shall prepare an acquisition strategy using...

  6. 48 CFR 18.113 - Interagency acquisitions under the Economy Act.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Interagency acquisitions under the Economy Act. 18.113 Section 18.113 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Available Acquisition Flexibilities 18.113 Interagency acquisitions under...

  7. 78 FR 78694 - Orders: Supplemental Orders on Reporting by Regulated Entities of Stress Testing Results as of...

    Science.gov (United States)

    2013-12-27

    ... reporting under section 165(i)(2) of the Dodd-Frank Wall Street Reform and Consumer Protection Act (Dodd... testing. II. Orders For the convenience of the affected parties, the text of the Supplemental Orders... Reform and Consumer Protection Act (``Dodd-Frank Act'') requires certain financial companies with total...

  8. 75 FR 57690 - Acquisition Regulation: Sustainable Acquisition

    Science.gov (United States)

    2010-09-22

    ... general guidelines issued by OMB. OMB's guidelines were published at 67 FR 8452 (February 22, 2002), and DOE's guidelines were published at 67 FR 62446 (October 7, 2002). DOE has reviewed today's rule under... products. (5) Environmentally preferable and energy efficient electronics including desktop computers...

  9. Calcium supplementation decreases BCP-induced inflammatory processes in blood cells through the NLRP3 inflammasome down-regulation.

    Science.gov (United States)

    Lagadec, Patricia; Balaguer, Thierry; Boukhechba, Florian; Michel, Grégory; Bouvet-Gerbettaz, Sébastien; Bouler, Jean-Michel; Scimeca, Jean-Claude; Rochet, Nathalie

    2017-07-15

    Interaction of host blood with biomaterials is the first event occurring after implantation in a bone defect. This study aimed at investigating the cellular and molecular consequences arising at the interface between whole blood and biphasic calcium phosphate (BCP) particles. We observed that, due to calcium capture, BCP inhibited blood coagulation, and that this inhibition was reversed by calcium supplementation. Therefore, we studied the impact of calcium supplementation on BCP effects on blood cells. Comparative analysis of BCP and calcium supplemented-BCP (BCP/Ca) effects on blood cells showed that BCP as well as BCP/Ca induced monocyte proliferation, as well as a weak but significant hemolysis. Our data showed for the first time that calcium supplementation of BCP microparticles had anti-inflammatory properties compared to BCP alone that induced an inflammatory response in blood cells. Our results strongly suggest that the anti-inflammatory property of calcium supplemented-BCP results from its down-modulating effect on P2X7R gene expression and its capacity to inhibit ATP/P2X7R interactions, decreasing the NLRP3 inflammasome activation. Considering that monocytes have a vast regenerative potential, and since the excessive inflammation often observed after bone substitutes implantation limits their performance, our results might have great implications in terms of understanding the mechanisms leading to an efficient bone reconstruction. Although scaffolds and biomaterials unavoidably come into direct contact with blood during bone defect filling, whole blood-biomaterials interactions have been poorly explored. By studying in 3D the interactions between biphasic calcium phosphate (BCP) in microparticulate form and blood, we showed for the first time that calcium supplementation of BCP microparticles (BCP/Ca) has anti-inflammatory properties compared to BCP-induced inflammation in whole blood cells and provided information related to the molecular mechanisms

  10. [Effect of antepartum taurine supplementation in regulating the activity of Rho family factors and promoting the proliferation of neural stem cells in neonatal rats with fetal growth restriction].

    Science.gov (United States)

    Li, Xiang-Wen; Li, Fang; Liu, Jing; Wang, Yan; Fu, Wei

    2016-11-01

    To study the possible effect of antepartum taurine supplementation in regulating the activity of Rho family factors and promoting the proliferation of neural stem cells in neonatal rats with fetal growth restriction (FGR), and to provide a basis for antepartum taurine supplementation to promote brain development in children with FGR. A total of 24 pregnant Sprague-Dawley rats were randomly divided into three groups: control, FGR, and taurine (n=8 each ). A rat model of FGR was established by food restriction throughout pregnancy. RT-PCR, immunohistochemistry, and Western blot were used to measure the expression of the specific intracellular markers for neural stem cells fatty acid binding protein 7 (FABP7), Rho-associated coiled-coil containing protein kinase 2 (ROCK2), ras homolog gene family, member A (RhoA), and Ras-related C3 botulinum toxin substrate (Rac). The FGR group had significantly lower OD value of FABP7-positive cells and mRNA and protein expression of FABP7 than the control group, and the taurine group had significantly higher OD value of FABP7-positive cells and mRNA and protein expression of FABP7 than the FGR group (Ptaurine group had significantly higher mRNA expression of RhoA and ROCK2 than the control group and significantly lower expression than the FGR group (Ptaurine group had significantly higher mRNA expression of Rac than the FGR and control groups (Ptaurine group had significantly lower protein expression of RhoA and ROCK2 than the FGR group (Ptaurine supplementation can promote the proliferation of neural stem cells in rats with FGR, and its mechanism may be related to the regulation of the activity of Rho family factors.

  11. 75 FR 34283 - Federal Acquisition Regulation; FAR Case 2009-025, Disclosure and Consistency of Cost Accounting...

    Science.gov (United States)

    2010-06-16

    ... Regulation (FAR) to align the FAR with the revised Cost Accounting Standards (CAS) Board clause, Disclosure....230-4 is replaced in its entirety and re-titled ``Disclosure and Consistency of Cost Accounting...) Disclosure and Consistency of Cost Accounting Practices-- Foreign Concerns. (1) The contracting officer shall...

  12. Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity

    Directory of Open Access Journals (Sweden)

    Croxatto Horacio B

    2011-01-01

    Full Text Available Abstract Background The endometrium is a dynamic tissue whose changes are driven by the ovarian steroidal hormones. Its main function is to provide an adequate substrate for embryo implantation. Using microarray technology, several reports have provided the gene expression patterns of human endometrial tissue during the window of implantation. However it is required that biological connections be made across these genomic datasets to take full advantage of them. The objective of this work was to perform a research synthesis of available gene expression profiles related to acquisition of endometrial receptivity for embryo implantation, in order to gain insights into its molecular basis and regulation. Methods Gene expression datasets were intersected to determine a consensus endometrial receptivity transcript list (CERTL. For this cluster of genes we determined their functional annotations using available web-based databases. In addition, promoter sequences were analyzed to identify putative transcription factor binding sites using bioinformatics tools and determined over-represented features. Results We found 40 up- and 21 down-regulated transcripts in the CERTL. Those more consistently increased were C4BPA, SPP1, APOD, CD55, CFD, CLDN4, DKK1, ID4, IL15 and MAP3K5 whereas the more consistently decreased were OLFM1, CCNB1, CRABP2, EDN3, FGFR1, MSX1 and MSX2. Functional annotation of CERTL showed it was enriched with transcripts related to the immune response, complement activation and cell cycle regulation. Promoter sequence analysis of genes revealed that DNA binding sites for E47, E2F1 and SREBP1 transcription factors were the most consistently over-represented and in both up- and down-regulated genes during the window of implantation. Conclusions Our research synthesis allowed organizing and mining high throughput data to explore endometrial receptivity and focus future research efforts on specific genes and pathways. The discovery of possible

  13. Energy acquisition in Brazilian captive market: incentives and risks of regulation; Aquisicao de energia no mercado cativo brasileiro: incentivos e riscos da regulacao

    Energy Technology Data Exchange (ETDEWEB)

    Barros, Monica; Mello, Marina Figueira de; Souza, Reinaldo Castro [Pontificia Universidade Catolica (PUC-Rio), Rio de Janeiro, RJ (Brazil). Inst. de Energia

    2008-07-01

    The new regulatory framework in Brazilian electricity sector implemented several changes in the way energy is traded. Energy required by all captive consumers is now centrally purchased by the regulator. Distributors are only responsible for demand estimation in their concession areas. In case estimations prove wrong, distributors are punished differently for under or overestimations. Underestimations are punished harder. In this paper we simulate energy purchasing costs for a hypothetical utility in which random percentages of the forecasted demand are used. We also develop a resampling scheme for the PLD (settlement price), which is used to calculate penalties incurred by utilities. We conclude that, despite a very sophisticated regulatory framework, the system is fragile because changes in the inputs of the NEWAVE software (used to calculate the marginal cost of operations, which directly affects the PLD) yield very different punishment fees for a given (fixed) acquisition strategy.

  14. Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2

    Science.gov (United States)

    O’Hagan, Kyle L.; Zhao, Jie; Pryshchep, Olga; Wang, Chyung-Ru

    2015-01-01

    NKT cells constitute a small population of T cells developed in the thymus that produce large amounts of cytokines and chemokines in response to lipid Ags. Signaling through the Vα14-Jα18 TCR instructs commitment to the NKT cell lineage, but the precise signaling mechanisms that instruct their lineage choice are unclear. In this article, we report that the cytoskeletal remodeling protein, p21-activated kinase 2 (Pak2), was essential for NKT cell development. Loss of Pak2 in T cells reduced stage III NKT cells in the thymus and periphery. Among different NKT cell subsets, Pak2 was necessary for the generation and function of NKT1 and NKT2 cells, but not NKT17 cells. Mechanistically, expression of Egr2 and promyelocytic leukemia zinc finger (PLZF), two key transcription factors for acquiring the NKT cell fate, were markedly diminished in the absence of Pak2. Diminished expression of Egr2 and PLZF were not caused by aberrant TCR signaling, as determined using a Nur77-GFP reporter, but were likely due to impaired induction and maintenance of signaling lymphocyte activation molecule 6 expression, a TCR costimulatory receptor required for NKT cell development. These data suggest that Pak2 controls thymic NKT cell development by providing a signal that links Egr2 to induce PLZF, in part by regulating signaling lymphocyte activation molecule 6 expression. PMID:26519537

  15. Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2.

    Science.gov (United States)

    O'Hagan, Kyle L; Zhao, Jie; Pryshchep, Olga; Wang, Chyung-Ru; Phee, Hyewon

    2015-12-01

    NKT cells constitute a small population of T cells developed in the thymus that produce large amounts of cytokines and chemokines in response to lipid Ags. Signaling through the Vα14-Jα18 TCR instructs commitment to the NKT cell lineage, but the precise signaling mechanisms that instruct their lineage choice are unclear. In this article, we report that the cytoskeletal remodeling protein, p21-activated kinase 2 (Pak2), was essential for NKT cell development. Loss of Pak2 in T cells reduced stage III NKT cells in the thymus and periphery. Among different NKT cell subsets, Pak2 was necessary for the generation and function of NKT1 and NKT2 cells, but not NKT17 cells. Mechanistically, expression of Egr2 and promyelocytic leukemia zinc finger (PLZF), two key transcription factors for acquiring the NKT cell fate, were markedly diminished in the absence of Pak2. Diminished expression of Egr2 and PLZF were not caused by aberrant TCR signaling, as determined using a Nur77-GFP reporter, but were likely due to impaired induction and maintenance of signaling lymphocyte activation molecule 6 expression, a TCR costimulatory receptor required for NKT cell development. These data suggest that Pak2 controls thymic NKT cell development by providing a signal that links Egr2 to induce PLZF, in part by regulating signaling lymphocyte activation molecule 6 expression. Copyright © 2015 by The American Association of Immunologists, Inc.

  16. Pasteurella pneumotropica evades the human complement system by acquisition of the complement regulators factor H and C4BP.

    Directory of Open Access Journals (Sweden)

    Alfredo Sahagún-Ruiz

    Full Text Available Pasteurella pneumotropica is an opportunist Gram negative bacterium responsible for rodent pasteurellosis that affects upper respiratory, reproductive and digestive tracts of mammals. In animal care facilities the presence of P. pneumotropica causes severe to lethal infection in immunodeficient mice, being also a potential source for human contamination. Indeed, occupational exposure is one of the main causes of human infection by P. pneumotropica. The clinical presentation of the disease includes subcutaneous abscesses, respiratory tract colonization and systemic infections. Given the ability of P. pneumotropica to fully disseminate in the organism, it is quite relevant to study the role of the complement system to control the infection as well as the possible evasion mechanisms involved in bacterial survival. Here, we show for the first time that P. pneumotropica is able to survive the bactericidal activity of the human complement system. We observed that host regulatory complement C4BP and Factor H bind to the surface of P. pneumotropica, controlling the activation pathways regulating the formation and maintenance of C3-convertases. These results show that P. pneumotropica has evolved mechanisms to evade the human complement system that may increase the efficiency by which this pathogen is able to gain access to and colonize inner tissues where it may cause severe infections.

  17. Data acquisition techniques using PC

    CERN Document Server

    Austerlitz, Howard

    1991-01-01

    Data Acquisition Techniques Using Personal Computers contains all the information required by a technical professional (engineer, scientist, technician) to implement a PC-based acquisition system. Including both basic tutorial information as well as some advanced topics, this work is suitable as a reference book for engineers or as a supplemental text for engineering students. It gives the reader enough understanding of the topics to implement a data acquisition system based on commercial products. A reader can alternatively learn how to custom build hardware or write his or her own software.

  18. Salinity reduces 2,4-D efficacy in Echinochloa crusgalli by affecting redox balance, nutrient acquisition, and hormonal regulation.

    Science.gov (United States)

    Islam, Faisal; Xie, Yuan; Farooq, Muhammad A; Wang, Jian; Yang, Chong; Gill, Rafaqat A; Zhu, Jinwen; Zhou, Weijun

    2018-05-01

    Distinct salinity levels have been reported to enhance plants tolerance to different types of stresses. The aim of this research is to assess the interaction of saline stress and the use of 2,4-D as a means of controlling the growth of Echinochloa crusgalli. The resultant effect of such interaction is vital for a sustainable approach of weed management and food production. The results showed that 2,4-D alone treatment reduces the chlorophyll contents, photosynthetic capacity, enhanced MDA, electrolyte leakage, and ROS production (H 2 O 2 , O 2 ·- ) and inhibited the activities of ROS scavenging enzymes. Further analysis of the ultrastructure of chloroplasts indicated that 2,4-D induced severe damage to the ultrastructure of chloroplasts and thylakoids. Severe saline stress (8 dS m -1 ) followed by mild saline stress treatments (4 dS m -1 ) also reduced the E. crusgalli growth, but had the least impact as compared to the 2,4-D alone treatment. Surprisingly, under combined treatments (salinity + 2,4-D), the phytotoxic effect of 2,4-D was reduced on saline-stressed E. crusgalli plants, especially under mild saline + 2,4-D treatment. This stimulated growth of E. crusgalli is related to the higher activities of enzymatic and non-enzymatic antioxidants and dynamic regulation of IAA, ABA under mild saline + 2,4-D treatment. This shows that 2,4-D efficacy was affected by salinity in a stress intensity-dependent manner, which may result in the need for greater herbicide application rates, additional application times, or more weed control operations required for controlling salt-affected weed.

  19. 30 CFR 256.12 - Supplemental sales.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Supplemental sales. 256.12 Section 256.12..., General § 256.12 Supplemental sales. (a) The Secretary may conduct a supplemental sale in accordance with the provisions of this section. (b) Supplemental sales shall be governed by the regulations in this...

  20. Dual RNA-seq transcriptional analysis of wheat roots colonized by Azospirillum brasilense reveals up-regulation of nutrient acquisition and cell cycle genes.

    Science.gov (United States)

    Camilios-Neto, Doumit; Bonato, Paloma; Wassem, Roseli; Tadra-Sfeir, Michelle Z; Brusamarello-Santos, Liziane C C; Valdameri, Glaucio; Donatti, Lucélia; Faoro, Helisson; Weiss, Vinicius A; Chubatsu, Leda S; Pedrosa, Fábio O; Souza, Emanuel M

    2014-05-16

    The rapid growth of the world's population demands an increase in food production that no longer can be reached by increasing amounts of nitrogenous fertilizers. Plant growth promoting bacteria (PGPB) might be an alternative to increase nitrogenous use efficiency (NUE) in important crops such wheat. Azospirillum brasilense is one of the most promising PGPB and wheat roots colonized by A. brasilense is a good model to investigate the molecular basis of plant-PGPB interaction including improvement in plant-NUE promoted by PGPB. We performed a dual RNA-Seq transcriptional profiling of wheat roots colonized by A. brasilense strain FP2. cDNA libraries from biological replicates of colonized and non-inoculated wheat roots were sequenced and mapped to wheat and A. brasilense reference sequences. The unmapped reads were assembled de novo. Overall, we identified 23,215 wheat expressed ESTs and 702 A. brasilense expressed transcripts. Bacterial colonization caused changes in the expression of 776 wheat ESTs belonging to various functional categories, ranging from transport activity to biological regulation as well as defense mechanism, production of phytohormones and phytochemicals. In addition, genes encoding proteins related to bacterial chemotaxi, biofilm formation and nitrogen fixation were highly expressed in the sub-set of A. brasilense expressed genes. PGPB colonization enhanced the expression of plant genes related to nutrient up-take, nitrogen assimilation, DNA replication and regulation of cell division, which is consistent with a higher proportion of colonized root cells in the S-phase. Our data support the use of PGPB as an alternative to improve nutrient acquisition in important crops such as wheat, enhancing plant productivity and sustainability.

  1. Cholesterol oxidation in meat products and its regulation by supplementation of sodium nitrite and apple polyphenol before processing.

    Science.gov (United States)

    Osada, K; Hoshina, S; Nakamura, S; Sugano, M

    2000-09-01

    The levels of cholesterol oxidation derivatives (OxChol) in eight commercial species of meat products were examined. These products contained more than 1 mg/100 g of OxChol, and 7beta-hydroxycholesterol + 5beta-epoxycholesterol (111-1092 microg/100 g), 5alpha-epoxycholesterol (80-712 microg/100 g), cholestanetriol (0-368 microg/100 g), and 7-ketocholesterol (708-1204 microg/100 g) were detected. To know the interaction of sodium nitrite supplementation against cholesterol oxidation in meat products, sausage was produced with or without varying levels of sodium nitrite and stored in the refrigerator for 15 days. As a result, cholesterol oxidation in sausage was inhibited by addition of sodium nitrite in a dose-dependent manner. This observation may be associated with inactivation of O(2)(-) radical and stabilization of polyunsaturated fatty acids (PUFAs). In fact, the levels of OxChol in sausage increased, accompanying the decrease of coexisting linoleic acid when sodium nitrite was not added to sausage meat. Thus, cholesterol oxidation in meat products seems to be considarably promoted by the oxidation of coexisting PUFAs. On the other hand, additive apple polyphenol also inhibited linoleic acid oxidation in sausage and then suppressed cholesterol oxidation through its radical scavenging effects. Therefore, apple polyphenol, having a large amount of an oligomer of catechin, may interfere with cholesterol oxidation in meat processing or storage of meat products through its antioxidative action and be useful as a new antioxitant for meat products when it is added to the original meat before processing.

  2. Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function

    Directory of Open Access Journals (Sweden)

    Brendan E. Russ

    2017-12-01

    Full Text Available Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the gene regulatory mechanisms that control these changes are largely unknown. Using ChIP-seq for specific histone post-translational modifications (PTMs, we mapped the dynamics of ∼25,000 putative CD8+ T cell transcriptional enhancers (TEs differentially utilized during virus-specific T cell differentiation. Interestingly, we identified a subset of dynamically regulated TEs that exhibited acquisition of a non-canonical (H3K4me3+ chromatin signature upon differentiation. This unique TE subset exhibited characteristics of poised enhancers in the naive CD8+ T cell subset and demonstrated enrichment for transcription factor binding motifs known to be important for virus-specific CD8+ T cell differentiation. These data provide insights into the establishment and maintenance of the gene transcription profiles that define each stage of virus-specific T cell differentiation.

  3. Understanding the acquisition and regulation mechanisms of the water chemistry in a clay formation: the CEC/ANDRA Archimede-argile project

    International Nuclear Information System (INIS)

    Merceron, T.; Mossmann, J.R.; Neerdael, B.; Canniere, P. de; Beaucaire, C.; Toulhoat, P.; Daumas, S.; Bianchi, A.; Christen, R.

    1993-01-01

    Clay formations are candidate host environments to high level radioactive waste repository. The radioelements could be partially released from the waste into the host geological formation after a very long time. Understanding behaviour of the natural chemical species is considered as a fundamental prerequisite before the disturbed system will be studied. Additional laboratory studies are also essential in order to forecast, by analogy, the behaviour of radioelements released from the radioactive waste repository. The ARCHIMEDE-ARGILE project has two main goals. The first is to gain an understanding of the mechanisms of acquisition and regulation of the water chemistry in a clay environment. This step is essential to predict both the behaviour and the migration in solution of artificial elements which are initially absent in the clay formation. The second is to test and validate in clay the measured physico chemical parameters which are the basis for the geochemical modelling of the behaviour of the natural and artificial radioelements. The paper presents the main results previously obtained on granitic waters and the research strategy established for the ARCHIMEDE project. (authors). 2 figs., 2 refs

  4. Data acquisition

    International Nuclear Information System (INIS)

    Clout, P.N.

    1982-01-01

    Data acquisition systems are discussed for molecular biology experiments using synchrotron radiation sources. The data acquisition system requirements are considered. The components of the solution are described including hardwired solutions and computer-based solutions. Finally, the considerations for the choice of the computer-based solution are outlined. (U.K.)

  5. Calcium supplements

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007477.htm Calcium supplements To use the sharing features on this page, please enable JavaScript. WHO SHOULD TAKE CALCIUM SUPPLEMENTS? Calcium is an important mineral for the ...

  6. SPORT SUPPLEMENTATION

    OpenAIRE

    Alexandаr Marinkov

    2016-01-01

    Sport supplementation is essential for athletes performance and achievements. The well balanced and structured supplementation is a challenge for sport medicine because must be done a balance between potential benefits and potential risks (anti-doping rule violations and others). In this review are structured the most used categories sport supplementations. Nutritional supplements used in sport could be divided in some main categories like: amino acids, vitamins, proteins and antioxidants. Fo...

  7. Alterative Expression and Localization of Profilin 1/VASPpS157 and Cofilin 1/VASPpS239 Regulates Metastatic Growth and is Modified by DHA Supplementation

    Science.gov (United States)

    Ali, Mehboob; Heyob, Kathryn; Jacob, Naduparambil K.; Rogers, Lynette K.

    2016-01-01

    Profilin 1, cofilin 1, and vasodialator stimulated phosphoprotein (VASP) are actin binding proteins (ABP) which regulate actin remodelling and facilitate cancer cell metastases. MiR~17–92 is highly expressed in metastatic tumors and profilin1 and cofilin1 are predicted targets. Docosahexaenoic acid (DHA) inhibits cancer cell proliferation and adhesion. These studies tested the hypothesis that the metastatic phenotype is driven by changes in ABPs including alternative phosphorylation and/or changes in subcellular localization. Additionally, we tested the efficacy of DHA supplementation to attenuate or inhibit these changes. Human lung cancer tissue sections were analyzed for F-actin content and expression and cellular localization of profilin1, cofilin1 and VASP (S157 or S239 phosphorylation). The metastatic phenotype was investigated in A549 and MLE12 cells lines using 8 Br-cAMP as a metastasis inducer and DHA as a therapeutic agent. Migration was assessed by wound assay and expression measured by western blot and confocal analysis. MiR~17–92 expression was measured by qRT-PCR. Results indicated increased expression and altered cellular distribution of profilin1/VASPpS157 but no changes in cofilin1/VASPpS239 in the human malignant tissues compared to normal tissues. In A549 and MLE12 cells, the expression patterns of profilin1/VASPpS157 or cofilin1/VASPpS239 suggested an interaction in regulation of actin dynamics. Furthermore, DHA inhibited cancer cell migration and viability, ABP expression and cellular localization, and modulated expression of miR~17–92 in A549 cells with minimal effects in MLE12 cells. Further investigations are warranted to understand ABP interactions, changes in cellular localization, regulation by miR~17–92, and DHA as a novel therapeutic. PMID:27496138

  8. Dietary supplement good manufacturing practices: preparing for compliance

    National Research Council Canada - National Science Library

    Mead, William J

    2012-01-01

    "Dietary Supplement GMP is a one-stop "how-to" road map to the final dietary supplement GMP regulations recently issued by the FDA covering the manufacture, packaging, and holding of dietary supplement...

  9. Oxytocin Signaling in Basolateral and Central Amygdala Nuclei Differentially Regulates the Acquisition, Expression, and Extinction of Context-Conditioned Fear in Rats

    Science.gov (United States)

    Campbell-Smith, Emma J.; Holmes, Nathan M.; Lingawi, Nura W.; Panayi, Marios C.; Westbrook, R. Frederick

    2015-01-01

    The present study investigated how oxytocin (OT) signaling in the central (CeA) and basolateral (BLA) amygdala affects acquisition, expression, and extinction of context-conditioned fear (freezing) in rats. In the first set of experiments, acquisition of fear to a shocked context was impaired by a preconditioning infusion of synthetic OT into the…

  10. 48 CFR 3032.003 - Simplified acquisition procedures financing.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Simplified acquisition procedures financing. 3032.003 Section 3032.003 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND... FINANCING Scope of Part 3032.003 Simplified acquisition procedures financing. Contract financing may be...

  11. 48 CFR 1.102-3 - Acquisition team.

    Science.gov (United States)

    2010-10-01

    ... service. By identifying the team members in this manner, teamwork, unity of purpose, and open... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acquisition team. 1.102-3... ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 1.102-3 Acquisition team. The purpose of defining...

  12. The pathway by which the yeast protein kinase Snf1p controls acquisition of sodium tolerance is different from that mediating glucose regulation.

    Science.gov (United States)

    Ye, Tian; Elbing, Karin; Hohmann, Stefan

    2008-09-01

    It recently became apparent that the highly conserved Snf1p protein kinase plays roles in controlling different cellular processes in the yeast Saccharomyces cerevisiae, in addition to its well-known function in glucose repression/derepression. We have previously reported that Snf1p together with Gis4p controls ion homeostasis by regulating expression of ENA1, which encodes the Ena1p Na(+) extrusion system. In this study we found that Snf1p is rapidly phosphorylated when cells are exposed to NaCl and this phosphorylation is required for the role of Snf1p in Na(+) tolerance. In contrast to activation by low glucose levels, the salt-induced phosphorylation of Snf1p promoted neither phosphorylation nor nuclear export of the Mig1p repressor. The mechanism that prevents Mig1p phosphorylation by active Snf1p under salt stress does not involve either hexokinase PII or the Gis4p regulator. Instead, Snf1p may mediate upregulation of ENA1 expression via the repressor Nrg1p. Activation of Snf1p in response to glucose depletion requires any of the three upstream protein kinases Sak1p, Tos3p and Elm1p, with Sak1p playing the most prominent role. The same upstream kinases were required for salt-induced Snf1p phosphorylation, and also under these conditions Sak1p played the most prominent role. Unexpectedly, however, it appears that Elm1p plays a dual role in acquisition of salt tolerance by activating Snf1p and in a presently unknown parallel pathway. Together, these results indicate that under salt stress Snf1p takes part in a different pathway from that during glucose depletion and this role is performed together as well as in parallel with its upstream kinase Elm1p. Snf1p appears to be part of a wider functional network than previously anticipated and the full complexity of this network remains to be elucidated.

  13. Supplemental and highly-elevated tocopherol doses differentially regulate allergic inflammation: reversibility of α-tocopherol and γ-tocopherol's effects

    OpenAIRE

    McCary, Christine A.; Abdala-Valencia, Hiam; Berdnikovs, Sergejs; Cook-Mills, Joan M.

    2011-01-01

    We have reported that supplemental doses of the α- and γ-tocopherol isoforms of vitamin E decrease and increase, respectively, allergic lung inflammation. We have now assessed whether these effects of tocopherols are reversible. For these studies, mice were treated with antigen and supplemental tocopherols in a first phase of treatment followed by a 4 week clearance phase and then the mice received a second phase of antigen and tocopherol treatments. The pro-inflammatory effects of supplement...

  14. Supplemental Colleges

    Data.gov (United States)

    Department of Homeland Security — The Supplemental Colleges layer attempts to capture additional Post Secondary Education campuses of colleges and universities associated with a single campus listed...

  15. Supplementation of branched-chain amino acids in protein-restricted diets modulates the expression levels of amino acid transporters and energy metabolism associated regulators in the adipose tissue of growing pigs

    Directory of Open Access Journals (Sweden)

    Yinghui Li

    2016-03-01

    Full Text Available This experiment was conducted to investigate the effects of branched-chain amino acids (BCAA supplemented in protein-restricted diets on the growth performance and the expression profile of amino acid transporters and energy metabolism related regulators in the white adipose tissue (WAT of different regional depots including dorsal subcutaneous adipose (DSA and abdominal subcutaneous adipose (ASA. A total of 24 crossbred barrows (7.40 ± 0.70 kg were randomly divided into 4 groups and were fed the following isocaloric diets for 33 days: 1 a recommended adequate protein diet (AP, 20% CP, as a positive control; 2 a low protein diet (LP, 17% CP; 3 the LP diet supplemented with BCAA (LP + B, 17% CP to reach the same level of the AP diet group; 4 the LP diet supplemented with 2 times the amount of BCAA (LP + 2B, 17% CP. The daily gain and daily feed intake of the LP diet group were the lowest among all the treatments (P  0.05. Moreover, BCAA supplementation down-regulated the expression levels of amino acid transporters including L-type amino acid transporter 1 and sodium-coupled neutral amino acid transporter 2 in DSA, but up-regulated the expression level of L-type amino acid transporter 4 in ASA (P < 0.05. Meanwhile, the energy sensor AMP-activated protein kinase α was activated in the DSA of pigs fed LP diet and in the ASA of the pigs fed AP or LP + 2B diets (P < 0.05. The mRNA expression profile of the selected mitochondrial component and mitochondrial biogenesis associated regulators in DSA and ASA also responded differently to dietary BCAA supplementation. These results suggested that the growth performance of growing pigs fed protein restricted diets supplemented with BCAA could catch up to that of the pigs fed AP diets. The results also partly demonstrated that the regulation mechanisms of BCAA are different in the adipose tissues of different depots.

  16. Mergers + acquisitions.

    Science.gov (United States)

    Hoppszallern, Suzanna

    2002-05-01

    The hospital sector in 2001 led the health care field in mergers and acquisitions. Most deals involved a network augmenting its presence within a specific region or in a market adjacent to its primary service area. Analysts expect M&A activity to increase in 2002.

  17. 43 CFR 7.32 - Supplemental definitions.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Supplemental definitions. 7.32 Section 7... RESOURCES Department of the Interior Supplemental Regulations § 7.32 Supplemental definitions. For purposes of this subpart, the following definitions will be used: (a) Site of religious or cultural importance...

  18. 77 FR 59339 - Acquisition of Commercial Items

    Science.gov (United States)

    2012-09-27

    ... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 212 Acquisition of Commercial Items CFR Correction 212.504 [Corrected] In Title 48 of the Code of Federal Regulations, Chapter 2 (Parts 201--299), revised as of October 1, 2011, on page 73, in section 212.504, paragraph (a) is...

  19. Mergers & Acquisitions

    DEFF Research Database (Denmark)

    Fomcenco, Alex

    This dissertation is a legal dogmatic thesis, the goal of which is to describe and analyze the current state of law in Europe in regard to some relevant selected elements related to mergers and acquisitions, and the adviser’s counsel in this regard. Having regard to the topic of the dissertation...... and fiscal neutrality, group-related issues, holding-structure issues, employees, stock exchange listing issues, and corporate nationality....

  20. Nutritional supplements

    DEFF Research Database (Denmark)

    Petersen, Gry Bjerg; Andersen, Jens Rikardt

    2015-01-01

    Background: Several studies have indicated that cancer patients have significantly altered taste sensitivity without specifying the preferences. One of the related problems is low compliance to nutritional therapy with oral nutritional supplements (ONS) in patients suffering severe weight loss...