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Sample records for regulation pr notice

  1. The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV.

    Directory of Open Access Journals (Sweden)

    Hanumant S Tanwar

    2017-02-01

    Full Text Available The interactions that occur during HIV Pr55Gag oligomerization and genomic RNA packaging are essential elements that facilitate HIV assembly. However, mechanistic details of these interactions are not clearly defined. Here, we overcome previous limitations in producing large quantities of full-length recombinant Pr55Gag that is required for isothermal titration calorimetry (ITC studies, and we have revealed the thermodynamic properties of HIV assembly for the first time. Thermodynamic analysis showed that the binding between RNA and HIV Pr55Gag is an energetically favourable reaction (ΔG<0 that is further enhanced by the oligomerization of Pr55Gag. The change in enthalpy (ΔH widens sequentially from: (1 Pr55Gag-Psi RNA binding during HIV genome selection; to (2 Pr55Gag-Guanosine Uridine (GU-containing RNA binding in cytoplasm/plasma membrane; and then to (3 Pr55Gag-Adenosine(A-containing RNA binding in immature HIV. These data imply the stepwise increments of heat being released during HIV biogenesis may help to facilitate the process of viral assembly. By mimicking the interactions between A-containing RNA and oligomeric Pr55Gag in immature HIV, it was noted that a p6 domain truncated Pr50Gag Δp6 is less efficient than full-length Pr55Gag in this thermodynamic process. These data suggest a potential unknown role of p6 in Pr55Gag-Pr55Gag oligomerization and/or Pr55Gag-RNA interaction during HIV assembly. Our data provide direct evidence on how nucleic acid sequences and the oligomeric state of Pr55Gag regulate HIV assembly.

  2. PR Toxin – Biosynthesis, Genetic Regulation, Toxicological Potential, Prevention and Control Measures: Overview and Challenges

    Directory of Open Access Journals (Sweden)

    Manish K. Dubey

    2018-03-01

    Full Text Available Out of the various mycotoxigenic food and feed contaminant, the fungal species belonging to Penicillium genera, particularly Penicillium roqueforti is of great economic importance, and well known for its crucial role in the manufacturing of Roquefort and Gorgonzola cheese. The mycotoxicosis effect of this mold is due to secretion of several metabolites, of which PR toxin is of considerable importance, with regard to food quality and safety challenges issues. The food products and silages enriched with PR toxin could lead into damage to vital internal organs, gastrointestinal perturbations, carcinogenicity, immunotoxicity, necrosis, and enzyme inhibition. Moreover, it also has the significant mutagenic potential to disrupt/alter the crucial processes like DNA replication, transcription, and translation at the molecular level. The high genetic diversities in between the various strains of P. roqueforti persuaded their nominations with Protected Geographical Indication (PGI, accordingly to the cheese type, they have been employed. Recently, the biosynthetic mechanism and toxicogenetic studies unraveled the role of ari1 and prx gene clusters that cross-talk with the synthesis of other metabolites or involve other cross-regulatory pathways to negatively regulate/inhibit the other biosynthetic route targeted for production of a strain-specific metabolites. Interestingly, the chemical conversion that imparts toxic properties to PR toxin is the substitution/oxidation of functional hydroxyl group (-OH to aldehyde group (-CHO. The rapid conversion of PR toxin to the other derivatives such as PR imine, PR amide, and PR acid, based on conditions available reflects their unstability and degradative aspects. Since the PR toxin-induced toxicity could not be eliminated safely, the assessment of dose-response and other pharmacological aspects for its safe consumption is indispensable. The present review describes the natural occurrences, diversity, biosynthesis

  3. PR Toxin - Biosynthesis, Genetic Regulation, Toxicological Potential, Prevention and Control Measures: Overview and Challenges.

    Science.gov (United States)

    Dubey, Manish K; Aamir, Mohd; Kaushik, Manish S; Khare, Saumya; Meena, Mukesh; Singh, Surendra; Upadhyay, Ram S

    2018-01-01

    Out of the various mycotoxigenic food and feed contaminant, the fungal species belonging to Penicillium genera, particularly Penicillium roqueforti is of great economic importance, and well known for its crucial role in the manufacturing of Roquefort and Gorgonzola cheese. The mycotoxicosis effect of this mold is due to secretion of several metabolites, of which PR toxin is of considerable importance, with regard to food quality and safety challenges issues. The food products and silages enriched with PR toxin could lead into damage to vital internal organs, gastrointestinal perturbations, carcinogenicity, immunotoxicity, necrosis, and enzyme inhibition. Moreover, it also has the significant mutagenic potential to disrupt/alter the crucial processes like DNA replication, transcription, and translation at the molecular level. The high genetic diversities in between the various strains of P. roqueforti persuaded their nominations with Protected Geographical Indication (PGI), accordingly to the cheese type, they have been employed. Recently, the biosynthetic mechanism and toxicogenetic studies unraveled the role of ari1 and prx gene clusters that cross-talk with the synthesis of other metabolites or involve other cross-regulatory pathways to negatively regulate/inhibit the other biosynthetic route targeted for production of a strain-specific metabolites. Interestingly, the chemical conversion that imparts toxic properties to PR toxin is the substitution/oxidation of functional hydroxyl group (-OH) to aldehyde group (-CHO). The rapid conversion of PR toxin to the other derivatives such as PR imine, PR amide, and PR acid, based on conditions available reflects their unstability and degradative aspects. Since the PR toxin-induced toxicity could not be eliminated safely, the assessment of dose-response and other pharmacological aspects for its safe consumption is indispensable. The present review describes the natural occurrences, diversity, biosynthesis, genetics

  4. PR Toxin – Biosynthesis, Genetic Regulation, Toxicological Potential, Prevention and Control Measures: Overview and Challenges

    Science.gov (United States)

    Dubey, Manish K.; Aamir, Mohd; Kaushik, Manish S.; Khare, Saumya; Meena, Mukesh; Singh, Surendra; Upadhyay, Ram S.

    2018-01-01

    Out of the various mycotoxigenic food and feed contaminant, the fungal species belonging to Penicillium genera, particularly Penicillium roqueforti is of great economic importance, and well known for its crucial role in the manufacturing of Roquefort and Gorgonzola cheese. The mycotoxicosis effect of this mold is due to secretion of several metabolites, of which PR toxin is of considerable importance, with regard to food quality and safety challenges issues. The food products and silages enriched with PR toxin could lead into damage to vital internal organs, gastrointestinal perturbations, carcinogenicity, immunotoxicity, necrosis, and enzyme inhibition. Moreover, it also has the significant mutagenic potential to disrupt/alter the crucial processes like DNA replication, transcription, and translation at the molecular level. The high genetic diversities in between the various strains of P. roqueforti persuaded their nominations with Protected Geographical Indication (PGI), accordingly to the cheese type, they have been employed. Recently, the biosynthetic mechanism and toxicogenetic studies unraveled the role of ari1 and prx gene clusters that cross-talk with the synthesis of other metabolites or involve other cross-regulatory pathways to negatively regulate/inhibit the other biosynthetic route targeted for production of a strain-specific metabolites. Interestingly, the chemical conversion that imparts toxic properties to PR toxin is the substitution/oxidation of functional hydroxyl group (-OH) to aldehyde group (-CHO). The rapid conversion of PR toxin to the other derivatives such as PR imine, PR amide, and PR acid, based on conditions available reflects their unstability and degradative aspects. Since the PR toxin-induced toxicity could not be eliminated safely, the assessment of dose-response and other pharmacological aspects for its safe consumption is indispensable. The present review describes the natural occurrences, diversity, biosynthesis, genetics

  5. 77 FR 42467 - Special Local Regulations; Fajardo Offshore Festival II, Fajardo, PR

    Science.gov (United States)

    2012-07-19

    ... 1625-AA08 Special Local Regulations; Fajardo Offshore Festival II, Fajardo, PR AGENCY: Coast Guard, DHS... Festival II, a series of high-speed boat races. The event is scheduled to take place on Sunday, September... the Fajardo Offshore Festival II. C. Discussion of Proposed Rule On September 16, 2012, Puerto Rico...

  6. Cell-cycle regulation of non-enzymatic functions of the Drosophila methyltransferase PR-Set7.

    Science.gov (United States)

    Zouaz, Amel; Fernando, Céline; Perez, Yannick; Sardet, Claude; Julien, Eric; Grimaud, Charlotte

    2018-04-06

    Tight cell-cycle regulation of the histone H4-K20 methyltransferase PR-Set7 is essential for the maintenance of genome integrity. In mammals, this mainly involves the interaction of PR-Set7 with the replication factor PCNA, which triggers the degradation of the enzyme by the CRL4CDT2 E3 ubiquitin ligase. PR-Set7 is also targeted by the SCFβ-TRCP ligase, but the role of this additional regulatory pathway remains unclear. Here, we show that Drosophila PR-Set7 undergoes a cell-cycle proteolytic regulation, independently of its interaction with PCNA. Instead, Slimb, the ortholog of β-TRCP, is specifically required for the degradation of the nuclear pool of PR-Set7 prior to S phase. Consequently, inactivation of Slimb leads to nuclear accumulation of PR-Set7, which triggers aberrant chromatin compaction and G1/S arrest. Strikingly, these phenotypes result from non-enzymatic PR-Set7 functions that prevent proper histone H4 acetylation independently of H4K20 methylation. Altogether, these results identify the Slimb-mediated PR-Set7 proteolysis as a new critical regulatory mechanism required for proper interphase chromatin organization at G1/S transition.

  7. Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation.

    Science.gov (United States)

    Bate, Clive; Nolan, William; Williams, Alun

    2016-01-01

    The prion diseases occur following the conversion of the cellular prion protein (PrP(C)) into disease-related isoforms (PrP(Sc)). In this study, the role of the glycosylphosphatidylinositol (GPI) anchor attached to PrP(C) in prion formation was examined using a cell painting technique. PrP(Sc) formation in two prion-infected neuronal cell lines (ScGT1 and ScN2a cells) and in scrapie-infected primary cortical neurons was increased following the introduction of PrP(C). In contrast, PrP(C) containing a GPI anchor from which the sialic acid had been removed (desialylated PrP(C)) was not converted to PrP(Sc). Furthermore, the presence of desialylated PrP(C) inhibited the production of PrP(Sc) within prion-infected cortical neurons and ScGT1 and ScN2a cells. The membrane rafts surrounding desialylated PrP(C) contained greater amounts of sialylated gangliosides and cholesterol than membrane rafts surrounding PrP(C). Desialylated PrP(C) was less sensitive to cholesterol depletion than PrP(C) and was not released from cells by treatment with glimepiride. The presence of desialylated PrP(C) in neurons caused the dissociation of cytoplasmic phospholipase A2 from PrP-containing membrane rafts and reduced the activation of cytoplasmic phospholipase A2. These findings show that the sialic acid moiety of the GPI attached to PrP(C) modifies local membrane microenvironments that are important in PrP-mediated cell signaling and PrP(Sc) formation. These results suggest that pharmacological modification of GPI glycosylation might constitute a novel therapeutic approach to prion diseases. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  8. 75 FR 42436 - Houston Pipe Line Company LP-Bammel Storage, Docket No. PR10-51-000, et. al.; Notice of Baseline...

    Science.gov (United States)

    2010-07-21

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Houston Pipe Line Company LP--Bammel Storage, Docket No. PR10-51- 000, et. al.; Notice of Baseline Filings July 14, 2010. Houston Pipe Line..., 2010, respectively the applicants listed above submitted their baseline filing of its Statement of...

  9. The effects of black cohosh on the regulation of estrogen receptor (ERα) and progesterone receptor (PR) in breast cancer cells.

    Science.gov (United States)

    Szmyd, Monica; Lloyd, Victoria; Hallman, Kelly; Aleck, Katie; Mladenovik, Viktoria; McKee, Christina; Morse, Mia; Bedgood, Tyler; Dinda, Sumi

    2018-01-01

    The North American plant Cimicifuga racemosa , also known as black cohosh (BC), is a herb that recently has gained attention for its hormonal effects. As the usage of hormone replacement therapy is declining due to its adverse effects in women with cancer, many are turning to herbal remedies like BC to treat menopausal symptoms. It is crucial to determine whether the effects of BC involve estrogen receptor-alpha (ERα). Previous studies from our laboratory have shown ERα to be a possible molecular target for BC. In this study, we examined the effects of BC (8% triterpene glycosides) alone and in combination with hormones and antihormones on the cellular viability, expression of ERα and progesterone receptor (PR)-A/B, and cytolocalization of ERα in ER (+) and PR-A/B (+) T-47D breast cancer cells. Cells were cultured and proteins were extracted and quantified. Western blot analysis revealed alterations in the expression of ERα and PR after treatment with BC (5-100 µM). BC induced a concentration-dependent decrease in ERα and PR protein levels when compared to the control. Image cytometric analysis with propidium iodide staining was used to enumerate changes in T-47D cell number and viability. A decrease in T-47D cell viability was observed upon treatment with 5-100 µM BC. The ideal concentration of BC (100 µM) was used in combination with hormones and antihormones in an effort to further understand the possible similarities between this compound and other known effectors of ERα and PR. After a 24-hour concomitant treatment with and/or in combination of BC, estradiol, ICI 182, 780, and Tamoxifen, downregulation of ERα and PR protein levels was observed. Delineating the role of BC in the regulation of ERα, PR, as well as its mechanisms of action, may be important in understanding the influence of BC on hormone receptors in breast cancer.

  10. Overexpression of NtPR-Q Up-Regulates Multiple Defense-Related Genes in Nicotiana tabacum and Enhances Plant Resistance to Ralstonia solanacearum

    Directory of Open Access Journals (Sweden)

    Yuanman Tang

    2017-11-01

    Full Text Available Various classes of plant pathogenesis-related proteins have been identified in the past several decades. PR-Q, a member of the PR3 family encoding chitinases, has played an important role in regulating plant resistance and preventing pathogen infection. In this paper, we functionally characterized NtPR-Q in tobacco plants and found that the overexpression of NtPR-Q in tobacco Yunyan87 resulted in higher resistance to Ralstonia solanacearum inoculation. Surprisingly, overexpression of NtPR-Q led to the activation of many defense-related genes, such as salicylic acid (SA-responsive genes NtPR1a/c, NtPR2 and NtCHN50, JA-responsive gene NtPR1b and ET production-associated genes NtACC Oxidase and NtEFE26. Consistent with the role of NtPR-Q in multiple stress responses, NtPR-Q transcripts were induced by the exogenous hormones SA, ethylene and methyl jasmonate, which could enhance the resistance of tobacco to R. solanacearum. Collectively, our results suggested that NtPR-Q overexpression led to the up-regulation of defense-related genes and enhanced plant resistance to R. solanacearum infection.

  11. 76 FR 43236 - Federal Travel Regulation (FTR): Temporary Duty (TDY) Travel Allowances: Notice of Public Meeting

    Science.gov (United States)

    2011-07-20

    ...; Sequence 5] Federal Travel Regulation (FTR): Temporary Duty (TDY) Travel Allowances: Notice of Public... public meeting. SUMMARY: The General Services Administration (GSA) is revising the Federal Travel Regulation (FTR) in an effort to streamline travel policies, increase travel efficiency and effectiveness...

  12. 77 FR 42465 - Special Local Regulations, Cruce a Nado Internacional, Ponce Harbor; Ponce, PR

    Science.gov (United States)

    2012-07-19

    ... effect on the human environment. This proposed rule involves special local regulations issued in.... Dated: June 7, 2012. D.W. Pearson, Captain, U.S. Coast Guard, Captain of the Port San Juan. [FR Doc...

  13. Expression of a serine protease gene prC is up-regulated by oxidative stress in the fungus Clonostachys rosea: implications for fungal survival.

    Directory of Open Access Journals (Sweden)

    Cheng-Gang Zou

    Full Text Available BACKGROUND: Soil fungi face a variety of environmental stresses such as UV light, high temperature, and heavy metals. Adaptation of gene expression through transcriptional regulation is a key mechanism in fungal response to environmental stress. In Saccharomyces cerevisiae, the transcription factors Msn2/4 induce stress-mediated gene expression by binding to the stress response element. Previous studies have demonstrated that the expression of extracellular proteases is up-regulated in response to heat shock in fungi. However, the physiological significance of regulation of these extracellular proteases by heat shock remains unclear. The nematophagous fungus Clonostachys rosea can secret an extracellular serine protease PrC during the infection of nematodes. Since the promoter of prC has three copies of the stress response element, we investigated the effect of environmental stress on the expression of prC. METHODOLOGY/PRINCIPAL FINDINGS: Our results demonstrated that the expression of prC was up-regulated by oxidants (H(2O(2 or menadione and heat shock, most likely through the stress response element. After oxidant treatment or heat shock, the germination of conidia in the wild type strain was significantly higher than that in the prC mutant strain in the presence of nematode cuticle. Interestingly, the addition of nematode cuticle significantly attenuated the production of reactive oxygen species (ROS induced by oxidants and heat shock in the wild type strain, but not in prC mutant strain. Moreover, low molecule weight (<3 kD degradation products of nematode cuticle suppressed the inhibitory effect of conidial germination induced by oxidants and heat shock. CONCLUSIONS/SIGNIFICANCE: These results indicate that PrC plays a protective role in oxidative stress in C. rosea. PrC degrades the nematode cuticle to produce degradation products, which in turn offer a protective effect against oxidative stress by scavenging ROS. Our study reveals a novel

  14. PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing Th17-cell differentiation and regulating cytokine production.

    Science.gov (United States)

    Liu, Haijie; Wan, Chunxiao; Ding, Yanan; Han, Ranran; He, Yating; Xiao, Jinting; Hao, Junwei

    2017-04-01

    Experimental autoimmune neuritis (EAN) is a CD4 + T-cell-mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system. It has been replicated in an animal model of human inflammatory demyelinating polyradiculoneuropathy, Guillain-Barré syndrome. In this study, we evaluated the therapeutic efficacy of a selective inhibitor of the immunoproteasome subunit, low-MW polypeptide 7 (PR-957) in rats with EAN. Our results showed that PR-957 significantly delayed onset day, reduced severity and shortened duration of EAN, and alleviated demyelination and inflammatory infiltration in sciatic nerves. In addition to significantly regulating expression of the cytokine profile, PR-957 treatment down-regulated the proportion of proinflammatory T-helper (T h )17 cells in sciatic nerves and spleens of rats with EAN. Data presented show the role of PR-957 in the signal transducer and activator of transcription 3 (STAT3) pathway. PR-957 not only decreased expression of IL-6 and IL-23 but also led to down-regulation of STAT3 phosphorylation in CD4 + T cells. Regulation of the STAT3 pathway led to a reduction in retinoid-related orphan nuclear receptor γ t and IL-17 production. Furthermore, reduction of STAT3 phosphorylation may have directly suppressed T h 17-cell differentiation. Therefore, our study demonstrates that PR-957 could potently alleviate inflammation in rats with EAN and that it may be a likely candidate for treating Guillain-Barré syndrome.-Liu, H., Wan, C., Ding, Y., Han, R., He, Y., Xiao, J., Hao, J. PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing T h 17-cell differentiation and regulating cytokine production. © FASEB.

  15. 78 FR 26246 - Special Local Regulation, 50 Aniversario Balneario de Boqueron, Bahia de Boqueron; Boqueron, PR

    Science.gov (United States)

    2013-05-06

    ... cumulatively have a significant effect on the human environment. This rule involves a special local regulation... be enforced from 9 a.m. until 4 p.m. on May 5, 2013. Dated: April 19, 2013. D.W. Pearson, Captain, U...

  16. 76 FR 46216 - Federal Travel Regulation (FTR): Temporary Duty (TDY) Travel Allowances: Notice of Public Meeting...

    Science.gov (United States)

    2011-08-02

    ...; Sequence 5] Federal Travel Regulation (FTR): Temporary Duty (TDY) Travel Allowances: Notice of Public... and the general public in an effort to streamline travel policies, incorporated travel efficiency and.... Flynn, Deputy Director, Office of Travel, Transportation & Asset Management. [FR Doc. 2011-19482 Filed 8...

  17. 75 FR 35019 - Hampshire Paper Company; Notice Rejecting Application, Waiving Regulations, and Soliciting...

    Science.gov (United States)

    2010-06-21

    ... Paper Company; Notice Rejecting Application, Waiving Regulations, and Soliciting Applications June 15, 2010. On June 2, 2010, Hampshire Paper Company (Hampshire Paper), licensee for the Emeryville....\\1\\ \\1\\ Hampshire Paper was issued a major license for the project on June 17, 1982, for a term of 30...

  18. 76 FR 71909 - Notice of Rescission of Certain Regulations

    Science.gov (United States)

    2011-11-21

    ... AGENCY: National Transportation Safety Board (NTSB). ACTION: Final rule. SUMMARY: The NTSB's regulations... FURTHER INFORMATION CONTACT: William C. Love, NTSB Designated Agency Ethics Official, 490 L'Enfant Plaza... of conduct''. Accordingly, OGE published a final rule entitled ``Standards of Ethical Conduct for...

  19. Evolutionary landscape of the Mycobacterium tuberculosis complex from the viewpoint of PhoPR: implications for virulence regulation and application to vaccine development.

    Science.gov (United States)

    Broset, Esther; Martín, Carlos; Gonzalo-Asensio, Jesús

    2015-10-20

    Different members of the Mycobacterium genus have evolved to cause tuberculosis in diverse human populations and in a variety of animal species. Our cumulative knowledge of mycobacterial genomes indicates that mutations in the PhoPR two-component virulence system were acquired not only during the natural evolution of mycobacterial species but also during in vitro subculture, which has given rise to the attenuated reference strain H37Ra or to different daughter strains of Mycobacterium bovis BCG. PhoPR is a well-known regulator of pathogenic phenotypes, including secretion of the virulence factor ESAT-6, biosynthesis of acyltrehalose-based lipids, and modulation of antigen export, in members of the Mycobacterium tuberculosis complex (MTBC). Evolutionarily conserved polymorphisms in PhoPR from Mycobacterium africanum, M. bovis, or M. tuberculosis H37Ra result in loss of functional phenotypes. Interestingly, some members of the MTBC have acquired compensatory mutations to counteract these polymorphisms and, probably, to maintain their pathogenic potential. Some of these compensatory mutations include the insertion of the IS6110 element upstream from phoPR in a particular M. bovis strain that is able to transmit between humans or polymorphisms in M. africanum and M. bovis that affect the regulatory region of the espACD operon, allowing PhoPR-independent ESAT-6 secretion. This review highlights the increasing knowledge of the significance of PhoPR in the evolution of the MTBC and its potential application in the construction of new attenuated vaccines based on phoPR inactivation. In this context, the live attenuated vaccine MTBVAC, based on a phoP fadD26 deletion mutant of M. tuberculosis, is the first vaccine of this kind to successfully enter into clinical development, representing a historic milestone in the field of human vaccinology. Copyright © 2015 Broset et al.

  20. Cell-specific regulation of proliferation by Ano1/TMEM16A in breast cancer with different ER, PR, and HER2 status.

    Science.gov (United States)

    Wu, Huizhe; Wang, Hui; Guan, Shu; Zhang, Jing; Chen, Qiuchen; Wang, Xiaodong; Ma, Ke; Zhao, Pengfei; Zhao, Haishan; Yao, Weifan; Jin, Feng; Xiao, Qinghuan; Wei, Minjie

    2017-10-17

    The calcium-activated chloride channel Ano1 (TMEM16A) is overexpressed in many tumors. However, conflicting data exist regarding the role of Ano1 in cell proliferation. Here, we performed immunohistochemistry to investigate the expression of Ano1 and Ki67 in 403 patients with breast cancer, and analyzed the association between the expression of Ano1 and Ki67 in breast cancer subtypes categorized according to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Ano1 expression was negatively correlated with Ki67 expression. Ano1 overexpression more frequently occurred in ER-positive or HER2-negative patients with the low expression of Ki67. Ano1 overexpression was associated with longer overall survival (OS) in breast cancer with the low expression of Ki67, especially in ER-positive, PR-positive, and HER2-negative breast cancer. Multivariate Cox regression analysis showed that Ano1 overexpression was a prognostic factor for longer overall survival in ER-positive, PR-positive, or HER2-negative patients with the low expression of Ki67. Furthermore, Ano1 promoted cell proliferation in ER-positive, PR-positive, and HER2-negative MCF7 cells, but inhibited cell proliferation in ER-negative, PR-negative, and HER2-negative MDA-MB-435S cells. Our findings suggest that Ano1 may differentially regulate cell proliferation in a subtype of breast cancer defined by ER, PR, and HER2. Combined expression of Ano1 and Ki67 may be used for predicting clinical outcomes of breast cancer patients with different subtypes of ER, PR, and HER2.

  1. Evolutionary Landscape of the Mycobacterium tuberculosis Complex from the Viewpoint of PhoPR: Implications for Virulence Regulation and Application to Vaccine Development

    Science.gov (United States)

    Broset, Esther

    2015-01-01

    ABSTRACT Different members of the Mycobacterium genus have evolved to cause tuberculosis in diverse human populations and in a variety of animal species. Our cumulative knowledge of mycobacterial genomes indicates that mutations in the PhoPR two-component virulence system were acquired not only during the natural evolution of mycobacterial species but also during in vitro subculture, which has given rise to the attenuated reference strain H37Ra or to different daughter strains of Mycobacterium bovis BCG. PhoPR is a well-known regulator of pathogenic phenotypes, including secretion of the virulence factor ESAT-6, biosynthesis of acyltrehalose-based lipids, and modulation of antigen export, in members of the Mycobacterium tuberculosis complex (MTBC). Evolutionarily conserved polymorphisms in PhoPR from Mycobacterium africanum, M. bovis, or M. tuberculosis H37Ra result in loss of functional phenotypes. Interestingly, some members of the MTBC have acquired compensatory mutations to counteract these polymorphisms and, probably, to maintain their pathogenic potential. Some of these compensatory mutations include the insertion of the IS6110 element upstream from phoPR in a particular M. bovis strain that is able to transmit between humans or polymorphisms in M. africanum and M. bovis that affect the regulatory region of the espACD operon, allowing PhoPR-independent ESAT-6 secretion. This review highlights the increasing knowledge of the significance of PhoPR in the evolution of the MTBC and its potential application in the construction of new attenuated vaccines based on phoPR inactivation. In this context, the live attenuated vaccine MTBVAC, based on a phoP fadD26 deletion mutant of M. tuberculosis, is the first vaccine of this kind to successfully enter into clinical development, representing a historic milestone in the field of human vaccinology. PMID:26489860

  2. 78 FR 7331 - SLR; Fajardo Offshore Grand Prix; Rada Fajardo; Fajardo, PR

    Science.gov (United States)

    2013-02-01

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 100 [Docket Number USCG-2012-1098] RIN 1625-AA08 SLR; Fajardo Offshore Grand Prix; Rada Fajardo; Fajardo, PR AGENCY: Coast Guard, DHS. ACTION: Notice of Proposed Rulemaking. SUMMARY: The Coast Guard is establishing a special local regulation on the...

  3. 75 FR 41855 - Enogex L.L.C.; Notice of Petition for Rate Approval

    Science.gov (United States)

    2010-07-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-52-000] Enogex L.L.C.; Notice of Petition for Rate Approval July 13, 2010. Take notice that on July 1, 2010, Enogex L.L.C. (Enogex) filed pursuant to section 284.123(b)(2) of the Commission's regulations, filed a petition...

  4. Canada's Patented Medicine Notice of Compliance regulations: balancing the scales or tipping them?

    Directory of Open Access Journals (Sweden)

    Lexchin Joel

    2011-03-01

    Full Text Available Abstract Background In order to comply with the provisions of the North American Free Trade Agreement, in 1993 the Canadian federal government introduced the Patented Medicine Notice of Compliance Linkage Regulations. These regulations were meant to achieve a balance between the timely entry of generic medicines and the rights of patent holders. The regulations tied the regulatory approval of generic medicines to the patent status of the original brand-name product. Discussion Since their introduction the regulations have been a source of contention between the generic and the brand-name industry. While the regulations have generated a considerable amount of work for the Federal Court of Canada both sides dispute the interpretation of the "win rate" in the court cases. Similarly, there is no agreement on whether multiple patents on single drugs represent a legitimate activity by the brand-name industry or an "evergreening" tactic. The generic industry's position is that the regulations are being abused leading to the delay in the introduction of lower cost generic products by as much as 8 years. The brand-name companies counter that the regulations are necessary because injunctions against the introduction of generic products are frequently unavailable to them. The regulations were amended in 2006 and again in 2008 but both sides continue to claim that the regulations favour the other party. The battle around the regulations also has an international dimension with interventions by PhRMA, the trade association representing the United States based multinational companies, arguing that the regulations are not stringent enough and that Canada needs to be placed on the U.S. Priority Watch List of countries. Finally, there are multiple costs to Canadian society as a result of the NOC regulations. Summary Despite the rhetoric there has been almost no empiric academic research done into the effect of the regulations. In order to develop rational policy

  5. 78 FR 13298 - Notice of Retrospective Review of the Americans With Disabilities Act Regulations for Over-the...

    Science.gov (United States)

    2013-02-27

    ... accessible OTRB service. An OTRB is defined as ``a bus characterized by an elevated passenger deck located...] Notice of Retrospective Review of the Americans With Disabilities Act Regulations for Over-the-Road Bus... bus (OTRB) operators. The DOT will review regulations specified in the SUPPLEMENTARY INFORMATION...

  6. 75 FR 68393 - Puerto Rico Disaster # PR-00011

    Science.gov (United States)

    2010-11-05

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12366 and 12367] Puerto Rico Disaster PR-00011 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster [[Page 68394

  7. 75 FR 44847 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

    Science.gov (United States)

    2010-07-29

    ... 943, 943-PR, 943- A, and 943A-PR AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and... comments concerning Forms 943, Employer's Annual Tax Return for Agricultural Employees, 943-PR, Planilla..., Agricultural Employer's Record of Federal Tax Liability, and 943A-PR, Registro De La Obligacion Contributiva...

  8. 78 FR 47051 - Proposed Collection; Comment Request for Forms 943, 943-PR, 943-A, and 943A-PR

    Science.gov (United States)

    2013-08-02

    ... 943, 943-PR, 943- A, and 943A-PR AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and..., 943-PR, Planilla Para La Declarcion Anual De La Contribucion Federal Del Patrono De Empleados Agricolas, 943-A, Agricultural Employer's Record of Federal Tax Liability, and 943A-PR, Registro De La...

  9. Design of Current-Controller with PR-regulator for LCL-Filter Based Grid-Connected Converter

    DEFF Research Database (Denmark)

    Zeng, Guohong; Rasmussen, Tonny Wederberg

    2010-01-01

    In the application of LCL-filter based converters, the structure and parameters of current-controller is very important for the system stability and output current quality. This paper presents a filter-capacitor current feedback control scheme for grid-connected converter. The controller...... is consisted of a proportional-resonance regulator and a proportional regulator. Unlike the existing control strategy with unit capacitor current feedback, the proposed method applies the proportional regulator to the feedback path, which can decouple these two regulators, and simplify the tuning process...... of the control strategy and the proposed current controller design method are verified by the simulation results of a 50kVA grid-connected inverter....

  10. CRISPR/Cas9-based knockouts reveal that CpRLP1 is a negative regulator of the sex pheromone PR-IP in the Closterium peracerosum-strigosum-littorale complex.

    Science.gov (United States)

    Kanda, Naho; Ichikawa, Machiko; Ono, Ayaka; Toyoda, Atsushi; Fujiyama, Asao; Abe, Jun; Tsuchikane, Yuki; Nishiyama, Tomoaki; Sekimoto, Hiroyuki

    2017-12-19

    Heterothallic strains of the Closterium peracerosum-strigosum-littorale (C. psl.) complex have two sexes, mating-type plus (mt + ) and mating-type minus (mt - ). Conjugation between these two sexes is regulated by two sex pheromones, protoplast-release-inducing protein (PR-IP) and PR-IP Inducer, which are produced by mt + and mt - cells, respectively. PR-IP mediates the release of protoplasts from mt - cells during mating. In this study, we examined the mechanism of action of CpRLP1 (receptor-like protein 1), which was previously identified in a cDNA microarray analysis as one of the PR-IP-inducible genes. Using CRISPR/Cas9 technology, we generated CpRLP1 knockout mutants in mt - cells of the C. psl. complex. When the knockout mt - cells were mixed with wild-type mt + cells, conjugation was severely reduced. Many cells released protoplasts without pairing, suggesting a loss of synchronization between the two mating partners. Furthermore, the knockout mutants were hypersensitive to PR-IP. We conclude that CpRLP1 is a negative regulator of PR-IP that regulates the timing of protoplast release in conjugating C. psl. cells. As the first report of successful gene knockout in the class Charophyceae, this study provides a basis for research aimed at understanding the ancestral roles of genes that are indispensable for the development of land plants.

  11. 75 FR 2165 - Puerto Rico Disaster No. PR-00007

    Science.gov (United States)

    2010-01-14

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration Nos. 12004 and 12005; Puerto Rico Disaster No. PR-00007] Puerto Rico Disaster No. PR-00007 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of...

  12. Legal status of minister's notices and technology standards of 'Korea institute of nuclear safety'(KINS) to regulate nuclear safety

    International Nuclear Information System (INIS)

    Jung, S. K.; Jung, M. M.; Kim, S. W.; Jang, K. H.; Oh, B. J.

    2003-01-01

    Concerning nuclear safety or technology standards, each of 'notices' issued by minister of science and technology(MOST) empowered by law of its regulation is obviously forceful as a law, if not all. But the standards made by the chief of Korea institute of nuclear safety(KINS) to meet the tasks entrusted to KINS by MOST is only conditionally forceful as a law, that is, on the condition that law or regulation empowered the chief of KINS to make nuclear safety and/or technology standards

  13. The PR/SET Domain Zinc Finger Protein Prdm4 Regulates Gene Expression in Embryonic Stem Cells but Plays a Nonessential Role in the Developing Mouse Embryo

    Science.gov (United States)

    Bogani, Debora; Morgan, Marc A. J.; Nelson, Andrew C.; Costello, Ita; McGouran, Joanna F.; Kessler, Benedikt M.

    2013-01-01

    Prdm4 is a highly conserved member of the Prdm family of PR/SET domain zinc finger proteins. Many well-studied Prdm family members play critical roles in development and display striking loss-of-function phenotypes. Prdm4 functional contributions have yet to be characterized. Here, we describe its widespread expression in the early embryo and adult tissues. We demonstrate that DNA binding is exclusively mediated by the Prdm4 zinc finger domain, and we characterize its tripartite consensus sequence via SELEX (systematic evolution of ligands by exponential enrichment) and ChIP-seq (chromatin immunoprecipitation-sequencing) experiments. In embryonic stem cells (ESCs), Prdm4 regulates key pluripotency and differentiation pathways. Two independent strategies, namely, targeted deletion of the zinc finger domain and generation of a EUCOMM LacZ reporter allele, resulted in functional null alleles. However, homozygous mutant embryos develop normally and adults are healthy and fertile. Collectively, these results strongly suggest that Prdm4 functions redundantly with other transcriptional partners to cooperatively regulate gene expression in the embryo and adult animal. PMID:23918801

  14. 21 CFR 10.80 - Dissemination of draft Federal Register notices and regulations.

    Science.gov (United States)

    2010-04-01

    ... petitioner relating to the draft will be recorded in a written memorandum, and all memoranda and... may discuss orally or in writing with an interested person ideas and recommendations for notices or... must be in writing and filed with the Division of Dockets Management. (2) A draft of a notice or...

  15. Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.

    Science.gov (United States)

    Patmanathan, Sathya Narayanan; Johnson, Steven P; Lai, Sook Ling; Panja Bernam, Suthashini; Lopes, Victor; Wei, Wenbin; Ibrahim, Maha Hafez; Torta, Federico; Narayanaswamy, Pradeep; Wenk, Markus R; Herr, Deron R; Murray, Paul G; Yap, Lee Fah; Paterson, Ian C

    2016-05-10

    Oral squamous cell carcinoma (OSCC) is a lethal disease with a 5-year mortality rate of around 50%. Molecular targeted therapies are not in routine use and novel therapeutic targets are required. Our previous microarray data indicated sphingosine 1-phosphate (S1P) metabolism and signalling was deregulated in OSCC. In this study, we have investigated the contribution of S1P signalling to the pathogenesis of OSCC. We show that the expression of the two major enzymes that regulate S1P levels were altered in OSCC: SPHK1 was significantly upregulated in OSCC tissues compared to normal oral mucosa and low levels of SGPL1 mRNA correlated with a worse overall survival. In in vitro studies, S1P enhanced the migration/invasion of OSCC cells and attenuated cisplatin-induced death. We also demonstrate that S1P receptor expression is deregulated in primary OSCCs and that S1PR2 is over-expressed in a subset of tumours, which in part mediates S1P-induced migration of OSCC cells. Lastly, we demonstrate that FTY720 induced significantly more apoptosis in OSCC cells compared to non-malignant cells and that FTY720 acted synergistically with cisplatin to induce cell death. Taken together, our data show that S1P signalling promotes tumour aggressiveness in OSCC and identify S1P signalling as a potential therapeutic target.

  16. 76 FR 79675 - DCP Raptor Pipeline, LLC; Notice of Extension of Time

    Science.gov (United States)

    2011-12-22

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR09-32-003] DCP Raptor Pipeline, LLC; Notice of Extension of Time On November 30, 2011, DCP Raptor Pipeline, LLC (Raptor) filed a...) of the Commission's regulations.\\1\\ In support of this request, Raptor states that in Order No. 735...

  17. 75 FR 51531 - Proposed Collection; Comment Request for Forms 941, 941-PR, 941-SS, 941-X, 941-X(PR), Schedule B...

    Science.gov (United States)

    2010-08-20

    ... 941, 941-PR, 941- SS, 941-X, 941-X(PR), Schedule B (Form 941), Schedule R (Form 941) and Schedule B (Form 941-PR) AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... comments concerning Forms 941 (Employer's Quarterly Federal Tax Return), 941-PR (Planilla Para La...

  18. 78 FR 47056 - Proposed Collection; Comment Request for Forms 941, 941-PR, 941-SS, 941-X, 941-X(PR), Schedule B...

    Science.gov (United States)

    2013-08-02

    ... 941, 941-PR, 941- SS, 941-X, 941-X(PR), Schedule B (Form 941), Schedule R (Form 941)and Schedule B (Form 941-PR) AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Forms 941 (Employer's Quarterly Federal Tax Return), 941-PR, 941-SS (Employer's Quarterly Federal Tax...

  19. 76 FR 5797 - Notice of Baseline Filings

    Science.gov (United States)

    2011-02-02

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-114-001; Docket No. PR10-129-001; Docket No. PR10-131- 001; Docket No. PR10-68-002 Not Consolidated] Notice of Baseline... applicants listed above submitted a revised baseline filing of their Statement of Operating Conditions for...

  20. 75 FR 70732 - Notice of Baseline Filings

    Science.gov (United States)

    2010-11-18

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-71-000; Docket No. PR11-72-000; Docket No. PR11-73- 000] Notice of Baseline Filings November 10, 2010. Docket No. PR11-71-000..., 2010, the applicants listed above submitted their baseline filing of their Statement of Operating...

  1. Consolidated permit regulations and hazardous waste management system: Environmental Protection Agency. Notice of issuance of regulation interpretation memorandum.

    Science.gov (United States)

    1981-12-10

    The Environmental Protection Agency (EPA) is issuing today a Regulation Interpretation Memorandum (RIM) which provides official interpretation of the issue of whether a generator who accumulates hazardous waste pursuant to 40 CFR 262.34, may qualify for interim status after November 19, 1980. This issue arose when the requirements for submitting a Part A permit application (one of the prerequisites to qualifying for interim status) were amended on November 19, 1980. The provisions interpreted today are part of the Consolidated Permit Regulations promulgated under Subtitle C of the Solid Waste Disposal Act, as amended by the Resource Conservation and Recovery Act, as amended (RCRA).

  2. Regulation

    International Nuclear Information System (INIS)

    Ballereau, P.

    1999-01-01

    The different regulations relative to nuclear energy since the first of January 1999 are given here. Two points deserve to be noticed: the decree of the third august 1999 authorizing the national Agency for the radioactive waste management to install and exploit on the commune of Bures (Meuse) an underground laboratory destined to study the deep geological formations where could be stored the radioactive waste. The second point is about the uranium residues and the waste notion. The judgment of the administrative tribunal of Limoges ( 9. july 1998) forbidding the exploitation of a storage installation of depleted uranium considered as final waste and qualifying it as an industrial waste storage facility has been annulled bu the Court of Appeal. It stipulated that, according to the law number 75663 of the 15. july 1965, no criteria below can be applied to depleted uranium: production residue (possibility of an ulterior enrichment), abandonment of a personal property or simple intention to do it ( future use aimed in the authorization request made in the Prefecture). This judgment has devoted the primacy of the waste notion on this one of final waste. (N.C.)

  3. 77 FR 467 - Notice of Tribal Consultation Meetings Regarding How the Current SACWIS Regulations Affect Tribes...

    Science.gov (United States)

    2012-01-05

    ... about current Federal regulations governing child welfare automation, please contact Mr. Peter Howe... consultation reflects our growing familiarity with the automation needs and preferences of Tribes and our... citing the related section of regulations or program guidance. (1) What are the obstacles for your Tribe...

  4. 78 FR 3495 - Puerto Rico Disaster #PR-00017

    Science.gov (United States)

    2013-01-16

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13437 and 13438] Puerto Rico Disaster PR-00017 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Puerto Rico Dated 01/03/2013. Incident: Heavy...

  5. 75 FR 39060 - Puerto Rico Disaster #PR-00009

    Science.gov (United States)

    2010-07-07

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12214 and 12215] Puerto Rico Disaster PR-00009 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the Commonwealth of Puerto Rico (FEMA-1919-DR...

  6. 76 FR 55155 - Puerto Rico Disaster #PR-00014

    Science.gov (United States)

    2011-09-06

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12768 and 12769] Puerto Rico Disaster PR-00014 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the Commonwealth of Puerto Rico (FEMA-4017-DR), dated 08/ 27/2011...

  7. 75 FR 51294 - Puerto Rico Disaster # PR-00010

    Science.gov (United States)

    2010-08-19

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12270 and 12271] Puerto Rico Disaster PR-00010 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of PUERTO RICO dated 08/11/2010. Incident: Severe...

  8. 75 FR 68394 - Puerto Rico Disaster # PR-00012

    Science.gov (United States)

    2010-11-05

    ... SMALL BUSINESS ADMINISTRATION Disaster Declaration 12368 and 12369 Puerto Rico Disaster PR-00012 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the Commonwealth of Puerto Rico (FEMA--1946--DR...

  9. 78 FR 4966 - Puerto Rico Disaster #PR-00018

    Science.gov (United States)

    2013-01-23

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 13445 and 13446] Puerto Rico Disaster PR-00018 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a notice of an Administrative declaration of a disaster for the Commonwealth of Puerto Rico dated 01/10/2013. Incident: Tropical...

  10. 76 FR 55154 - Puerto Rico Disaster #PR-00015

    Science.gov (United States)

    2011-09-06

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12770 and 12771] Puerto Rico Disaster PR-00015 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the Commonwealth of Puerto Rico (FEMA-4017-DR...

  11. 76 FR 44647 - Puerto Rico Disaster #PR-00013

    Science.gov (United States)

    2011-07-26

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12699 and 12700] Puerto Rico Disaster PR-00013 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for Public Assistance Only for the Commonwealth of Puerto Rico (FEMA-4004-DR...

  12. 76 FR 66768 - Puerto Rico Disaster #PR-00016

    Science.gov (United States)

    2011-10-27

    ... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12897 and 12898] Puerto Rico Disaster PR-00016 AGENCY: U.S. Small Business Administration. ACTION: Notice. SUMMARY: This is a Notice of the Presidential declaration of a major disaster for the Commonwealth of Puerto Rico (FEMA-4040-DR), dated 10/ 18/2011...

  13. 78 FR 13662 - Cobra Pipeline Ltd.; Notice of Petition

    Science.gov (United States)

    2013-02-28

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. PR13-32-000; PR13-33-000] Cobra Pipeline Ltd.; Notice of Petition Take notice that on February 4, 2013, Cobra Pipeline Ltd. (Cobra... Docket No. PR13-11-000, as more fully detailed in the petitions. Any person desiring to participate in...

  14. Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions.

    Science.gov (United States)

    Proietti, Cecilia J; Cenciarini, Mauro E; Elizalde, Patricia V

    2018-05-01

    Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine-dependent breast cancer. As a member of the nuclear receptor family of ligand-dependent transcription factors, the main action of PR is to regulate networks of target gene expression in response to binding its cognate steroid hormone, progesterone. Liganded-PR transcriptional activation has been thoroughly studied and associated mechanisms have been described while progesterone-mediated repression has remained less explored. The present work summarizes recent advances in the understanding of how PR-mediated repression is accomplished in breast cancer cells and highlights the significance of fully understanding the determinants of context-dependent PR action. Copyright © 2018 Elsevier Inc. All rights reserved.

  15. 75 FR 57268 - Notice of Baseline Filings

    Science.gov (United States)

    2010-09-20

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-103-000; Docket No. PR10-104-000; Docket No. PR10-105- 000 (Not Consolidated)] Notice of Baseline Filings September 13..., 2010, and September 10, 2010, respectively the applicants listed above submitted their baseline filing...

  16. 75 FR 65010 - Notice of Baseline Filings

    Science.gov (United States)

    2010-10-21

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-1-000; Docket No. PR11-2-000; Docket No. PR11-3-000] Notice of Baseline Filings October 14, 2010. Cranberry Pipeline Docket..., 2010, respectively the applicants listed above submitted their baseline filing of its Statement of...

  17. 17 CFR 248.123 - Contents of opt out notice; consolidated and equivalent notices.

    Science.gov (United States)

    2010-04-01

    ... EXCHANGE COMMISSION (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.123 Contents of opt out notice; consolidated and equivalent notices. (a) Contents of opt out...) The name of the affiliate(s) providing the notice. If the notice is provided jointly by multiple...

  18. 76 FR 78640 - Hattiesburg Industrial Gas Sales, L.L.C.; Notice of Filing

    Science.gov (United States)

    2011-12-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. PR12-8-000 and PR12-9-000] Hattiesburg Industrial Gas Sales, L.L.C.; Notice of Filing Take notice that on December 9, 2011, Hattiesburg Industrial Gas Sales, L.L.C. (Hattiesburg) filed in PR12-8-000 a Statement of Operating Conditions (SOC) with...

  19. 75 FR 53963 - Notice of Baseline Filings: The Peoples Gas Light and Coke Company, Minnesota Energy Resources...

    Science.gov (United States)

    2010-09-02

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-86-000, Docket No. PR10-87-000, Docket No. PR10-88- 000, Docket No. PR10-89-000, Docket No. PR10-90-000] Notice of Baseline Filings: The Peoples Gas Light and Coke Company, Minnesota Energy Resources Corporation, Louisville Gas...

  20. Germinação de sementes de jenipapeiro submetidas à pré-embebição em regulador e estimulante vegetal Seed germination of genipap submitted to pre-soaking in regulator and plant stimulante

    Directory of Open Access Journals (Sweden)

    Manoel Prado Neto

    2007-06-01

    Full Text Available Objetivou-se avaliar a germinação de sementes e crescimento inicial de plântulas de jenipapo (Genipa americana L. submetidas à pré-embebição em regulador e estimulante vegetal. Utilizou-se delineamento inteiramente casualizado com quatro repetições de 25 sementes e oito tratamentos, nos quais as sementes foram embebidas por 12 horas em: T1 - água, T2 - Giberelina líquida a 4% de GA3 (GA3 4% L a 50 mL L-1, T3 - (GA3 4% L a 100 mL L-1, T4 - (GA3 4% L a 200 mL L-1 , T5 - (GA3 4% L a 300 mL L-1, T6 - (GA3 4% L a 400 mL L-1, T7 - Stimulate® a 5 mL L-1 e T8 - Stimulate® a 10 mL L-1. As sementes foram dispostas sobre folhas de papel toalha previamente umedecidas com água destilada e levadas para o germinador, regulado a 28ºC, avaliando-se porcentagem de germinação, comprimento da raiz, do hipocótilo e total da plântula 21 dias após a semeadura e Índice de Velocidade de Germinação. Não houve efeito da pré-embebição na germinação das sementes com variação entre 89 a 95%. Os resultados obtidos evidenciaram que a pré-embebição de sementes de jenipapo por 12 horas em 4% GA3 L (50, 100 e 200 mL L-1 e Stimulate® (10 mL L-1, proporcionam maiores índices de velocidade de germinação. O Stimulate® 10 mL L-¹, em pré-embebição por 12 horas proporciona maiores comprimentos das raízes e total das plântulas de jenipapo em relação aos demais tratamentos.This work aimed to evaluate the genipap (Genipa americana L. seed germination and its initial seedling growth, submitted to pre-soaking in regulator and vegetal stimulant. It was arranged in a randomized design with four repetitions of 25 seeds and eight treatments, in which seeds were impregnated for 12 hours: T1 - water, T2 - Liquid gibberellins 4% GA3 (GA3 4% L (50 mL L-1, T3 - (GA3 4% L (100 mL L-1, T4 - (GA3 4% L (200 mL L-1, T5 - (GA3 4% L (300 mL L-1, T6 - (GA3 4% L (400 mL L-1, T7 - Stimulate® (5 mL L-1 e T8 - Stimulate® (10 mL L-1. The seeds were disposed on a

  1. 75 FR 66748 - Notice of Baseline Filings

    Science.gov (United States)

    2010-10-29

    ...- 000] Notice of Baseline Filings October 22, 2010. ONEOK Gas Transportation, L.L.C Docket No. PR11-68... above submitted a revised baseline filing of their Statement of Operating Conditions for services...

  2. Down-regulation of osmotin (PR5) gene by virus-induced gene silencing (VIGS) leads to susceptibility of resistant Piper colubrinum Link. to the oomycete pathogen Phytophthora capsici Leonian.

    Science.gov (United States)

    Anu, K; Jessymol, K K; Chidambareswaren, M; Gayathri, G S; Manjula, S

    2015-06-01

    Piper colubrinum Link., a distant relative of Piper nigrum L., is immune to the oomycete pathogen Phytophthora capsici Leonian that causes 'quick wilt' in cultivated black pepper (P. nigrum). The osmotin, PR5 gene homologue, earlier identified from P. colubrinum, showed significant overexpression in response to pathogen and defense signalling molecules. The present study focuses on the functional validation of P. colubrinum osmotin (PcOSM) by virus induced gene silencing (VIGS) using Tobacco Rattle Virus (TRV)-based vector. P. colubrinum plants maintained under controlled growth conditions in a growth chamber were infiltrated with Agrobacterium carrying TRV empty vector (control) and TRV vector carrying PcOSM. Three weeks post infiltration, viral movement was confirmed in newly emerged leaves of infiltrated plants by RT-PCR using TRV RNA1 and TRV RNA2 primers. Semi-quantitative RT-PCR confirmed significant down-regulation of PcOSM gene in TRV-PcOSM infiltrated plant compared with the control plants. The control and silenced plants were challenged with Phytophthora capsici which demonstrated that knock-down of PcOSM in P. colubrinum leads to increased fungal mycelial growth in silenced plants compared to control plants, which was accompanied by decreased accumulation of H2O2 as indicated by 3,3'-diaminobenzidine (DAB) staining. Thus, in this study, we demonstrated that Piper colubrinum osmotin gene is required for resisting P. capsici infection and has possible role in hypersensitive cell death response and oxidative burst signaling during infection.

  3. 76 FR 8725 - Notice of Baseline Filings

    Science.gov (United States)

    2011-02-15

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Baseline Filings Enstor Grama Ridge Storage and Docket No. PR10-97-002. Transportation, L.L.C.. EasTrans, LLC Docket No. PR10-30-001... revised baseline filing of their Statement of Operating Conditions for services provided under section 311...

  4. PrPC from stem cells to cancer

    Directory of Open Access Journals (Sweden)

    Séverine eMartin-Lannerée

    2014-09-01

    Full Text Available The cellular prion protein PrPC was initially discovered as the normal counterpart of the pathological scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. While clues as to the physiological function of this ubiquitous protein were greatly anticipated from the development of knock-out animals, PrP-null mice turned out to be viable and to develop without major phenotypic abnormalities. Notwithstanding, the discovery that hematopoietic stem cells from PrP-null mice have impaired long-term repopulating potential has set the stage for investigating into the role of PrPC in stem cell biology. A wealth of data have now exemplified that PrPC is expressed in distinct types of stem cells and regulates their self-renewal as well as their differentiation potential. A role for PrPC in the fate restriction of embryonic stem cells has further been proposed. Paralleling these observations, an overexpression of PrPC has been documented in various types of tumours. In line with the contribution of PrPC to stemness and to the proliferation of cancer cells, PrPC was recently found to be enriched in subpopulations of tumour-initiating cells. In the present review, we summarize the current knowledge of the role played by PrPC in stem cell biology and discuss how the subversion of its function may contribute to cancer progression.

  5. PR-PR: cross-platform laboratory automation system.

    Science.gov (United States)

    Linshiz, Gregory; Stawski, Nina; Goyal, Garima; Bi, Changhao; Poust, Sean; Sharma, Monica; Mutalik, Vivek; Keasling, Jay D; Hillson, Nathan J

    2014-08-15

    To enable protocol standardization, sharing, and efficient implementation across laboratory automation platforms, we have further developed the PR-PR open-source high-level biology-friendly robot programming language as a cross-platform laboratory automation system. Beyond liquid-handling robotics, PR-PR now supports microfluidic and microscopy platforms, as well as protocol translation into human languages, such as English. While the same set of basic PR-PR commands and features are available for each supported platform, the underlying optimization and translation modules vary from platform to platform. Here, we describe these further developments to PR-PR, and demonstrate the experimental implementation and validation of PR-PR protocols for combinatorial modified Golden Gate DNA assembly across liquid-handling robotic, microfluidic, and manual platforms. To further test PR-PR cross-platform performance, we then implement and assess PR-PR protocols for Kunkel DNA mutagenesis and hierarchical Gibson DNA assembly for microfluidic and manual platforms.

  6. 17 CFR 239.500 - Form D, notice of sales of securities under Regulation D and section 4(6) of the Securities Act...

    Science.gov (United States)

    2010-04-01

    ... amount since the previously filed notice of sales on Form D, does not result in an increase of more than... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Form D, notice of sales of... ACT OF 1933 Forms Pertaining to Exemptions § 239.500 Form D, notice of sales of securities under...

  7. Intenções reprodutivas e práticas de regulação da fecundidade entre universitários Reproductive intentions and fertility regulation practices among university students

    Directory of Open Access Journals (Sweden)

    Kátia Cibelle Machado Pirotta

    2004-08-01

    Full Text Available OBJETIVO: Identificar as intenções reprodutivas e caracterizar as práticas de regulação da fecundidade, abarcando a contracepção e o aborto, entre um grupo de adolescentes e jovens de alta escolaridade. MÉTODOS: Os dados foram levantados a partir de um estudo amplo quali-quantitativo com estudantes de graduação com idade de até 24 anos, de uma universidade pública estadual localizada na cidade de São Paulo. A população estudada foi constituída de 952 estudantes que freqüentavam disciplinas sorteadas pelo método de sorteio aleatório; e numa segunda etapa foram realizadas 33 entrevistas em profundidade com alunos voluntários. Na primeira etapa, os alunos foram entrevistados em sala de aula, através de um questionário auto-aplicável e, na segunda etapa, foram gravadas entrevistas em profundidade, realizadas em um local previamente combinado. RESULTADOS: O padrão de família idealizado pelo grupo era pequeno, com até dois filhos. A idade considerada ideal no nascimento do primeiro filho seria próxima aos 30 anos. Os estudantes referiram uma alta proporção de uso de contraceptivos - sobretudo do condom e da pílula. Ao lado disso, observa-se uma alta proporção de gestações finalizadas pelo aborto. Como resultante desse quadro, a fecundidade é bastante baixa no grupo, ou seja, 27 estudantes referiram uma ou mais gestações. Os dados qualitativos não foram objeto de análise. CONCLUSÕES: Embora o tamanho idealizado para a família reflita uma tendência geral presente na sociedade brasileira, constata-se que o grupo adia a maternidade/paternidade em função de um projeto de vida orientado para a conclusão de um curso superior e a inserção no mercado de trabalho. Ainda assim, a contracepção e a prevenção das doenças sexualmente transmissíveis são vivenciadas precariamente.OBJECTIVE: To identify reproductive intentions and fertility regulation practices, including contraception and abortion, in a group of

  8. Novel receptor-like kinases in cacao contain PR-1 extracellular domains.

    Science.gov (United States)

    Teixeira, Paulo José Pereira Lima; Costa, Gustavo Gilson Lacerda; Fiorin, Gabriel Lorencini; Pereira, Gonçalo Amarante Guimarães; Mondego, Jorge Maurício Costa

    2013-08-01

    Members of the pathogenesis-related protein 1 (PR-1) family are well-known markers of plant defence responses, forming part of the arsenal of the secreted proteins produced on pathogen recognition. Here, we report the identification of two cacao (Theobroma cacao L.) PR-1s that are fused to transmembrane regions and serine/threonine kinase domains, in a manner characteristic of receptor-like kinases (RLKs). These proteins (TcPR-1f and TcPR-1g) were named PR-1 receptor kinases (PR-1RKs). Phylogenetic analysis of RLKs and PR-1 proteins from cacao indicated that PR-1RKs originated from a fusion between sequences encoding PR-1 and the kinase domain of a LecRLK (Lectin Receptor-Like Kinase). Retrotransposition marks surround TcPR-1f, suggesting that retrotransposition was involved in the origin of PR-1RKs. Genes with a similar domain architecture to cacao PR-1RKs were found in rice (Oryza sativa), barrel medic (Medicago truncatula) and a nonphototrophic bacterium (Herpetosiphon aurantiacus). However, their kinase domains differed from those found in LecRLKs, indicating the occurrence of convergent evolution. TcPR-1g expression was up-regulated in the biotrophic stage of witches' broom disease, suggesting a role for PR-1RKs during cacao defence responses. We hypothesize that PR-1RKs transduce a defence signal by interacting with a PR-1 ligand. © 2013 BSPP AND JOHN WILEY & SONS LTD.

  9. Neutron Scattering from fcc Pr and Pr3Tl

    DEFF Research Database (Denmark)

    Birgeneau, R. J.; Als-Nielsen, Jens Aage; Bucher, E.

    1972-01-01

    Elastic-neutron-scattering measurements on the singlet-ground-state ferromagnets fcc Pr and Pr3 Tl are reported. Both exhibit magnetic phase transitions, possibly to a simple ferromagnetic state at 20 and 11.6 °K, respectively. The transitions appear to be of second order although that in fcc Pr...

  10. 75 FR 54692 - Notice of Debarment Pursuant to Section 127.7(c) of the International Traffic in Arms Regulations

    Science.gov (United States)

    2010-09-08

    ... International Traffic in Arms Regulations Title: Bureau of Political-Military Affairs; Statutory Debarment under... Compliance, Bureau of Political-Military Affairs, Department of State (202) 663-2980. SUPPLEMENTARY.... Statutory debarment is based solely upon conviction in a criminal proceeding, conducted by a United States...

  11. Ubiquitin Ligase gp78 Targets Unglycosylated Prion Protein PrP for Ubiquitylation and Degradation

    OpenAIRE

    Shao, Jia; Choe, Vitnary; Cheng, Haili; Tsai, Yien Che; Weissman, Allan M.; Luo, Shiwen; Rao, Hai

    2014-01-01

    Prion protein PrP is a central player in several devastating neurodegenerative disorders, including mad cow disease and Creutzfeltd-Jacob disease. Conformational alteration of PrP into an aggregation-prone infectious form PrPSc can trigger pathogenic events. How levels of PrP are regulated is poorly understood. Human PrP is known to be degraded by the proteasome, but the specific proteolytic pathway responsible for PrP destruction remains elusive. Here, we demonstrate that the ubiquitin ligas...

  12. PR, Lobbyism and Democracy

    DEFF Research Database (Denmark)

    Ørsten, Mark; Willig, Ida; Pedersen, Leif Hemming

    2017-01-01

    The growth of PR in Scandinavia is linked both to the mediatization of politics and to the decline of corporatism. Studies in Sweden and Norway suggest that one consequence of these changes is the increasing number of politicians who find new careers as lobbyists in the private sector. In this st......The growth of PR in Scandinavia is linked both to the mediatization of politics and to the decline of corporatism. Studies in Sweden and Norway suggest that one consequence of these changes is the increasing number of politicians who find new careers as lobbyists in the private sector....... Still, 89 percent of all the registered job positions fall outside of lobbyism. 11 percent of the job positions fall within the wider field associated with the emerging field of policy professionals (including lobbyism), while lobbyism on its own accounts for 2 percent of the job positions....

  13. 76 FR 70438 - Enterprise Intrastate L.P., Enterprise Texas Pipeline LLC; Notice of Filing

    Science.gov (United States)

    2011-11-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-4-000; Docket No. PR12-5-000; Not Consolidated] Enterprise Intrastate L.P., Enterprise Texas Pipeline LLC; Notice of Filing Take notice that on November 1, 2011, the applicants listed above filed a revised Statement of...

  14. 75 FR 65467 - Enterprise Alabama Intrastate, LLC; Enterprise Intrastate L.P; Notice of Baseline Filings

    Science.gov (United States)

    2010-10-25

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-4-000; Docket No. PR11-5-000; Not Consolidated] Enterprise Alabama Intrastate, LLC; Enterprise Intrastate L.P; Notice of Baseline Filings October 18, 2010. Take notice that on October 15, 2010, the applicants listed above...

  15. 76 FR 13610 - Enterprise Texas Pipeline LLC; Notice of Compliance Filing

    Science.gov (United States)

    2011-03-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. PR10-14-002; PR11-92-000] Enterprise Texas Pipeline LLC; Notice of Compliance Filing Take notice that on March 1, 2011, Enterprise Texas Pipeline LLC (Enterprise Texas) filed a revised Statement of Rates to its Statement of Operating...

  16. Progesterone receptors (PR) mediate STAT actions: PR and prolactin receptor signaling crosstalk in breast cancer models.

    Science.gov (United States)

    Leehy, Katherine A; Truong, Thu H; Mauro, Laura J; Lange, Carol A

    2018-02-01

    Estrogen is the major mitogenic stimulus of mammary gland development during puberty wherein ER signaling acts to induce abundant PR expression. PR signaling, in contrast, is the primary driver of mammary epithelial cell proliferation in adulthood. The high circulating levels of progesterone during pregnancy signal through PR, inducing expression of the prolactin receptor (PRLR). Cooperation between PR and prolactin (PRL) signaling, via regulation of downstream components in the PRL signaling pathway including JAKs and STATs, facilitates the alveolar morphogenesis observed during pregnancy. Indeed, these pathways are fully integrated via activation of shared signaling pathways (i.e. JAKs, MAPKs) as well as by the convergence of PRs and STATs at target genes relevant to both mammary gland biology and breast cancer progression (i.e. proliferation, stem cell outgrowth, tissue cell type heterogeneity). Thus, rather than a single mediator such as ER, transcription factor cascades (ER>PR>STATs) are responsible for rapid proliferative and developmental programming in the normal mammary gland. It is not surprising that these same mediators typify uncontrolled proliferation in a majority of breast cancers, where ER and PR are most often co-expressed and may cooperate to drive malignant tumor progression. This review will primarily focus on the integration of PR and PRL signaling in breast cancer models and the importance of this cross-talk in cancer progression in the context of mammographic density. Components of these PR/PRL signaling pathways could offer alternative drug targets and logical complements to anti-ER or anti-estrogen-based endocrine therapies. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. 48 CFR 49.607 - Delinquency notices.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Delinquency notices. 49... MANAGEMENT TERMINATION OF CONTRACTS Contract Termination Forms and Formats 49.607 Delinquency notices. The formats of the delinquency notices in this section may be used to satisfy the requirements of 49.402-3...

  18. 16 CFR 1502.33 - Official notice.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Official notice. 1502.33 Section 1502.33 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS... notice may be taken of such matters as might be judicially noticed by the courts of the United States or...

  19. Préface

    Science.gov (United States)

    Chardonnet, Christian; Millot, Guy

    2006-10-01

    COLOQ, réunion nationale biennale initiée en 1988 par la communauté française des lasers, de l'optique non linéaire et de l'optique quantique atteint sa neuvième édition. Depuis sa création, les objectifs poursuivis sont les suivants : - réunir la communauté française des lasers, de l'optique non linéaire et de l'optique quantique, en dépassant les clivages fondamental/appliqué, recherche publique/industrielle, - faire le point sur les avancées récentes, - permettre aux jeunes chercheurs de se rencontrer, de s'exprimer et de s'aguerrir au plan national. Le but est que tout thésard du domaine de l'optique puisse participer à COLOQ une fois durant sa thèse, présenter son travail et de se confronter à la communauté de l'optique. COLOQ9 s'est tenu, pour sa 9e édition, sur le campus universitaire de Dijon, du 7 au 9 septembre 2005. Il a été une grande réussite : nombre de participants (255) et de présentations scientifiques record (148 affiches), forte représentation des industriels (15) et participation d'environ 200 lycéens aux conférences grand public. Le nombre plus élevé que prévu d'affiches a rendu un peu serrée leur présentation : une attention particulière sera portée à cet aspect lors des prochaines éditions. Ces journées ont été consacrées à des conférences invitées données par des scientifiques de haut niveau et à des présentations sous forme d'affiches. Une plage de temps importante a été réservée pour des discussions autour des affiches. À proximité immédiate de la salle de conférence, l'exposition de matériels spécialisés pour les lasers, l'optique et l'optoélectronique a été une occasion pour les jeunes participants de découvrir et contacter les industriels et les autres grands acteurs de l'optique. L'année 2005 ayant été l'année mondiale de la physique, COLOQ9 a retenu comme thème central ”1905-2005 : à propos d'Einstein". Plusieurs grandes conférences ont été dédiées à ce th

  20. Présentation

    Directory of Open Access Journals (Sweden)

    Stéphane Haber

    2010-08-01

    Full Text Available Les articles réunis dans ce dossier de la revue Astérion portent sur la première génération de la Théorie critique (dont Max Horkheimer, Walter Benjamin, Theodor W. Adorno, Herbert Marcuse et Erich Fromm constituent sans doute les figures principales. Ils se concentrent plus précisément sur les contributions philosophiques qui marquèrent la période ouverte par l’accession de Horkheimer à la direction de l’Institut de recherches sociales (1931 et close par la publication en 1944 de Dialektik...

  1. Silencing of acidic pathogenesis-related PR-1 genes increases extracellular beta-(1 -> 3)-glucanase activity at the onset of tobacco defence reactions

    DEFF Research Database (Denmark)

    Riviere, M.P.; Marais, A.; Ponchet, M.

    2008-01-01

    silenced. Plants lacking extracellular PR-1s were more susceptible than wild-type plants to the oomycete Phytophthora parasitica but displayed unaffected systemic acquired resistance and developmental resistance to this pathogen. Treatment with salicylic acid up-regulates the PR-1g gene, encoding a basic...... protein of the PR-1 family, in PR-1-deficient tobacco, indicating that PR-1 expression may repress that of PR-1g. This shows that acidic PR-1s are dispensable for expression of salicylic acid-dependent acquired resistances against P. parasitica and may reveal a functional overlap in tobacco defence......The class 1 pathogenesis-related (PR) proteins are thought to be involved in plant defence responses, but their molecular functions are unknown. The function of PR-1 was investigated in tobacco by generating stable PR-1a-silenced lines in which other acidic PR-1 genes (PR-1b and PR-1c) were...

  2. On PR group classes and PR algebra membership

    International Nuclear Information System (INIS)

    Lebedenko, V.M.

    1978-01-01

    The necessary and sufficient conditions are found for the membership of Lee algebras to PR algebra class, to algebras with commutation relations of [Hsub(i), Hsub(j)]=rsub(ij)Hsub(i) (i< j) type. Due to this, a criterion is obtained for the membership of the Lee froups to PR group classes, connected and simply connected Lee groups, which Lee algebras are PR algebras

  3. Single-Phase 3L PR Controlled qZS Inverter Connected to the Distorted Grid

    DEFF Research Database (Denmark)

    Makovenko, Elena; Husev, Oleksandr; Roncero-Clemente, Carlos

    2016-01-01

    This paper presents a single-phase three-level NPC qZS inverter connected to a distorted grid using PID and PR regulators. A case study system along with the control strategy are described. Tuning approaches for PID and PR regulators are addressed and validated by means of simulation results...

  4. Antimicrobial and immunomodulatory activities of PR-39 derived peptides.

    Directory of Open Access Journals (Sweden)

    Edwin J A Veldhuizen

    Full Text Available The porcine cathelicidin PR-39 is a host defence peptide that plays a pivotal role in the innate immune defence of the pig against infections. Besides direct antimicrobial activity, it is involved in immunomodulation, wound healing and several other biological processes. In this study, the antimicrobial- and immunomodulatory activity of PR-39, and N- and C-terminal derivatives of PR-39 were tested. PR-39 exhibited an unexpected broad antimicrobial spectrum including several Gram positive strains such as Bacillus globigii and Enterococcus faecalis. Of organisms tested, only Staphylococcus aureus was insensitive to PR-39. Truncation of PR-39 down to 15 (N-terminal amino acids did not lead to major loss of activity, while peptides corresponding to the C-terminal part of PR-39 were hampered in their antimicrobial activity. However, shorter peptides were all much more sensitive to inhibition by salt. Active peptides induced ATP leakage and loss of membrane potential in Bacillus globigii and Escherichia coli, indicating a lytic mechanism of action for these peptides. Finally, only the mature peptide was able to induce IL-8 production in porcine macrophages, but some shorter peptides also had an effect on TNF-α production showing differential regulation of cytokine induction by PR-39 derived peptides. None of the active peptides showed high cytotoxicity highlighting the potential of these peptides for use as an alternative to antibiotics.

  5. Antimicrobial and Immunomodulatory Activities of PR-39 Derived Peptides

    Science.gov (United States)

    Veldhuizen, Edwin J. A.; Schneider, Viktoria A. F.; Agustiandari, Herfita; van Dijk, Albert; Tjeerdsma-van Bokhoven, Johanna L. M.; Bikker, Floris J.; Haagsman, Henk P.

    2014-01-01

    The porcine cathelicidin PR-39 is a host defence peptide that plays a pivotal role in the innate immune defence of the pig against infections. Besides direct antimicrobial activity, it is involved in immunomodulation, wound healing and several other biological processes. In this study, the antimicrobial- and immunomodulatory activity of PR-39, and N- and C-terminal derivatives of PR-39 were tested. PR-39 exhibited an unexpected broad antimicrobial spectrum including several Gram positive strains such as Bacillus globigii and Enterococcus faecalis. Of organisms tested, only Staphylococcus aureus was insensitive to PR-39. Truncation of PR-39 down to 15 (N-terminal) amino acids did not lead to major loss of activity, while peptides corresponding to the C-terminal part of PR-39 were hampered in their antimicrobial activity. However, shorter peptides were all much more sensitive to inhibition by salt. Active peptides induced ATP leakage and loss of membrane potential in Bacillus globigii and Escherichia coli, indicating a lytic mechanism of action for these peptides. Finally, only the mature peptide was able to induce IL-8 production in porcine macrophages, but some shorter peptides also had an effect on TNF-α production showing differential regulation of cytokine induction by PR-39 derived peptides. None of the active peptides showed high cytotoxicity highlighting the potential of these peptides for use as an alternative to antibiotics. PMID:24755622

  6. STRATEGIJSKA ULOGA PR U SPORTU

    Directory of Open Access Journals (Sweden)

    Duško Tomić

    2005-05-01

    Full Text Available PR in the modern world are developed with rapid speed and become important aspect of strategic management. Modern menagers are very interesting in PR and they observe that there is not successful strategy without experiance theory and practice in PR. The goals must be defined, basic phylosophy to, and managers must take responsability and describe everithing what they have to do. It must be financial fond and evaluation must be done

  7. Préface

    Directory of Open Access Journals (Sweden)

    Sylvie Duvillard

    2010-09-01

    Full Text Available Le moment est opportun, la question foncière est de retour, légitimée par presque une décennie (2001-2008 d’augmentation continue des prix de l’immobilier. De « sommets » , en articles de presse, la montagne et les Alpes en particulier font l’objet, dans ce domaine, d’une attention toute particulière. Le contexte est ici délicat. Les sociétés alpines sont partagées entre désir de préservation d’une forte identité montagnarde et crainte d’une « déprise » économique (agricole, touristique et/...

  8. Présentation

    Directory of Open Access Journals (Sweden)

    Frédéric Hitzel

    2009-05-01

    Full Text Available « À ma connaissance, il n'est pas de compagnon plus fidèle à ses engagements, plus prompt à honorer les faveurs reçues, plus empressé à offrir ses services, et ce à moindre frais, que le livre. Je ne connais aucun arbre qui ait un fruit plus succulent, plus précoce, plus aisé à cueillir, plus disponible à tout moment, comme le livre. Je ne sais pas de produit qui, malgré son jeune âge et la proximité de sa naissance, la facilité avec laquelle on peut se le procurer, la modicité de son prix, a...

  9. Présentation

    Directory of Open Access Journals (Sweden)

    Agnès Bouvier

    2012-02-01

    Full Text Available Le 7 juin 1844, Flaubert écrit à Louis de Cormenin : « J’ai lu Candide vingt fois, je l’ai traduit en anglais et je l’ai encore relu de temps à autre. » Quel que soit le degré de sérieux de cette affirmation, elle témoigne d’un intérêt précoce de Flaubert pour l’acte de traduire. De même, l’écrivain attachait de l’importance aux traductions qu’il lisait : « Je relis maintenant Don Quichotte dans la nouvelle traduction de Damas Hinard » écrit-il à Louise Colet en novembre 1847. Il lui arrivait...

  10. Présentation

    Directory of Open Access Journals (Sweden)

    Aurore Monod Becquelin

    2010-09-01

    Full Text Available Les recherches présentées dans ce volume sont issues des travaux de chercheurs qui se réunissent régulièrement depuis 2005 sur le thème de l’« Agentivité ». Ce groupe rassemble des ethnologues et des linguistes du Laboratoire d’ethnologie et de sociologie comparative (umr 7186, cnrs/université Paris Ouest Nanterre La Défense, du Laboratoire d’anthropologie sociale (umr 7130, Collège de France/ehess Paris/cnrs, de l’École des hautes études en sciences sociales, de l’Institut des hautes étude...

  11. 12 CFR 222.26 - Delivery of opt-out notices.

    Science.gov (United States)

    2010-01-01

    ... SYSTEM FAIR CREDIT REPORTING (REGULATION V) Affiliate Marketing § 222.26 Delivery of opt-out notices. (a... the affiliate providing the notice; or (4) Posts the notice on the Internet Web site at which the... affiliate providing the notice; or (3) Posts the notice on an Internet Web site without requiring the...

  12. State diagram of Pr-Bi system

    International Nuclear Information System (INIS)

    Abulkhaev, V.L.; Ganiev, I.N.

    1994-01-01

    By means of thermal differential analysis, X-ray and microstructural analysis the state diagram of Pr-Bi system was studied. Following intermetallic compounds were defined in the system: Pr 2 Bi, Pr 5 Bi 3 , Pr 4 Bi 3 , Pr Bi, PrBi 2 , Pr 2 Bi, Pr 5 Bi 3 , Pr 4 Bi 3 and PrBi 2 . The data analysis on Ln-Bi diagram allowed to determine the regularity of change of properties of intermetallic compounds in the line of rare earth elements of cerium subgroup.

  13. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.

    Science.gov (United States)

    Zhang, Guoqi; Yang, Li; Kim, Gab Seok; Ryan, Kieran; Lu, Shulin; O'Donnell, Rebekah K; Spokes, Katherine; Shapiro, Nathan; Aird, William C; Kluk, Michael J; Yano, Kiichiro; Sanchez, Teresa

    2013-07-18

    The endothelium, as the interface between blood and all tissues, plays a critical role in inflammation. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid, highly abundant in plasma, that potently regulates endothelial responses through interaction with its receptors (S1PRs). Here, we studied the role of S1PR2 in the regulation of the proadhesion and proinflammatory phenotype of the endothelium. By using genetic approaches and a S1PR2-specific antagonist (JTE013), we found that S1PR2 plays a key role in the permeability and inflammatory responses of the vascular endothelium during endotoxemia. Experiments with bone marrow chimeras (S1pr2(+/+) → S1pr2(+/+), S1pr2(+/+) → S1pr2(-/-), and S1pr2(-/-) → S1pr2(+/+)) indicate the critical role of S1PR2 in the stromal compartment, in the regulation of vascular permeability and vascular inflammation. In vitro, JTE013 potently inhibited tumor necrosis factor α-induced endothelial inflammation. Finally, we provide detailed mechanisms on the downstream signaling of S1PR2 in vascular inflammation that include the activation of the stress-activated protein kinase pathway that, together with the Rho-kinase nuclear factor kappa B pathway (NF-kB), are required for S1PR2-mediated endothelial inflammatory responses. Taken together, our data indicate that S1PR2 is a key regulator of the proinflammatory phenotype of the endothelium and identify S1PR2 as a novel therapeutic target for vascular disorders.

  14. 77 FR 56837 - Enterprise Intrastate LLC; Notice of Filing

    Science.gov (United States)

    2012-09-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-34-000] Enterprise Intrastate LLC; Notice of Filing Take notice that on September 6, 2012, Enterprise Intrastate LLC (Enterprise.... Enterprise Intrastate is revising its SOC to replace all references to ``Enterprise Intrastate L.P.'' with...

  15. 78 FR 28837 - Acadian Gas Pipeline System; Notice of Petition

    Science.gov (United States)

    2013-05-16

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-129-001] Acadian Gas Pipeline System; Notice of Petition Take notice that on May 6, 2013, Acadian Gas Pipeline System (Acadian... concerns filed in the September 26, 2011 filing, as more fully detailed in the petition. Any person...

  16. 75 FR 30014 - Consumers Energy Company; Notice of Baseline Filing

    Science.gov (United States)

    2010-05-28

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-25-000] Consumers Energy Company; Notice of Baseline Filing May 21, 2010. Take notice that on May 17, 2010, Consumers Energy Company (Consumers) submitted a baseline filing of its Statement of Operating Conditions for the...

  17. 77 FR 31841 - Hope Gas, Inc.; Notice of Baseline Filing

    Science.gov (United States)

    2012-05-30

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-23-001] Hope Gas, Inc.; Notice of Baseline Filing Take notice that on May 16, 2012, Hope Gas, Inc. (Hope Gas) submitted a revised baseline filing of their Statement of Operating Conditions for services provided under Section 311 of the...

  18. 77 FR 26535 - Hope Gas, Inc.; Notice of Baseline Filing

    Science.gov (United States)

    2012-05-04

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-23-000] Hope Gas, Inc.; Notice of Baseline Filing Take notice that on April 26, 2012, Hope Gas, Inc. (Hope Gas) submitted a baseline filing of their Statement of Operating Conditions for services provided under Section 311 of the...

  19. The PR Officer's Survival Kit.

    Science.gov (United States)

    Woodrum, Robert L.

    1996-01-01

    A former corporate public relations (PR) professional shares strategies for communicating and cooperating with the chief executive officer, and particularly for coping with differences in perceptions of the public relations officer's role. Basic attributes of a successful PR professional are outlined: good communication skills, an analytical…

  20. PR's involvement in International Cooperation

    NARCIS (Netherlands)

    Anonymous,

    1995-01-01

    In The Netherlands, the Research Station for Cattle, Sheep and Horse Husbandry (in Dutch abbreviated as PR) bridges the gap between more basic and disciplinary research done at universities and research institutes on the one hand and the extension service and the farmers on the other hand. The PR

  1. Prólogo

    Directory of Open Access Journals (Sweden)

    Alta Hooker

    2013-02-01

    Full Text Available Este volumen No. 11 presenta una compilación estructurada en 6 secciones temáticas las cuales comprenden 9 artículos. La primera sección en Educación, presenta los artículos: Métodos de enseñanza de Física en la modalidad a distancia en el instituto sabatino “Esperanza”,en el municipio de Siuna; y, Comportamiento disciplinario en la escuela “Niño Jesús”, Siuna, Región Autónoma Atlántico Norte, 2011. La segunda sección, titulada Educación Superior en la Costa Caribe Nicaragüense presenta los artículos: Formación de los docentes de la URACCAN en el Área de Recursos Naturales; asimismo, Pertinencia de los programas para el aprendizaje del inglés en Administración de Empresas, Recinto Nueva Guinea y Prácticas de campo en la formación de estudiantes de Ingeniería en Zootecnia, URACCAN Nueva Guinea. La tercera sección denominada Revitalización Lingüística y Cultural comprende dos artículos: Etno-matemática en indígenas ulwas, comunidad de Karawala, Región Autónoma Atlántico Sur, Nicaragua y Ma-Kuagro: Elementos de la cultura de San Basilio Palenque, Colombia, y su incidencia en las prácticas pedagógicas. La cuarta sección Cultura Indígena y Afrodescendiente comprende un artículo: Economía indígena en la comunidad de Wasakín, municipio de Rosita, RAAN. Clausura la quinta sección denominada Ciencias Sociales, el artículo La república Bolivariana de Venezuela y Nicaragua, en el marco del acuerdo energético.

  2. Interferon-Stimulated Genes Are Transcriptionally Repressed by PR in Breast Cancer.

    Science.gov (United States)

    Walter, Katherine R; Goodman, Merit L; Singhal, Hari; Hall, Jade A; Li, Tianbao; Holloran, Sean M; Trinca, Gloria M; Gibson, Katelin A; Jin, Victor X; Greene, Geoffrey L; Hagan, Christy R

    2017-10-01

    The progesterone receptor (PR) regulates transcriptional programs that drive proliferation, survival, and stem cell phenotypes. Although the role of native progesterone in the development of breast cancer remains controversial, PR clearly alters the transcriptome in breast tumors. This study identifies a class of genes, Interferon (IFN)-stimulated genes (ISGs), potently downregulated by ligand-activated PR which have not been previously shown to be regulated by PR. Progestin-dependent transcriptional repression of ISGs was observed in breast cancer cell line models and human breast tumors. Ligand-independent regulation of ISGs was also observed, as basal transcript levels were markedly higher in cells with PR knockdown. PR repressed ISG transcription in response to IFN treatment, the canonical mechanism through which these genes are activated. Liganded PR is robustly recruited to enhancer regions of ISGs, and ISG transcriptional repression is dependent upon PR's ability to bind DNA. In response to PR activation, key regulatory transcription factors that are required for IFN-activated ISG transcription, STAT2 and IRF9, exhibit impaired recruitment to ISG promoter regions, correlating with PR/ligand-dependent ISG transcriptional repression. IFN activation is a critical early step in nascent tumor recognition and destruction through immunosurveillance. As the large majority of breast tumors are PR positive at the time of diagnosis, PR-dependent downregulation of IFN signaling may be a mechanism through which early PR-positive breast tumors evade the immune system and develop into clinically relevant tumors. Implications: This study highlights a novel transcriptional mechanism through which PR drives breast cancer development and potentially evades the immune system. Mol Cancer Res; 15(10); 1331-40. ©2017 AACR . ©2017 American Association for Cancer Research.

  3. Préface

    Science.gov (United States)

    Aspect, Alain

    2004-11-01

    COLOQ est une conférence regroupant, tous les deux ans, la communauté scientifique et industrielle nationale travaillant dans les domaines des lasers, de l'optique non-linéaire et de l'optique quantique. Elle s'est tenue pour sa huitième édition à Toulouse, du 3 au 5 septembre 2004, sur le campus de I'INSA. Comme il est de tradition tous les quatre ans, COLOQ était couplé avec Horizons de l'optique, avec en particulier une journée commune dont le programme avait été préparé en concertation par les deux comités scientifiques. Depuis sa création, COLOQ a pour but de favoriser les rencontres entre les chercheurs des différents laboratoires nationaux publics ou privés travaillant sur les lasers et l'optique quantique au sens large. C'est un moyen privilégié de resserrer les liens de cette communauté et d'y intégrer les jeunes chercheurs. Ces derniers y trouvent l'occasion de se connaître, de se faire connaître, de découvrir la communauté à laquelle ils appartiennent et d'élargir leurs connaissances des thèmes qui la structurent. La participation de 230 chercheurs et d'une vingtaine d'exposants de matériels spécialisés dans les lasers et l'optoélectronique témoigne de la vitalité de COLOQ et de son audience dans les laboratoires et chez les industriels de l'optique. Le programme de COLOQ 8 comportait d'une vingtaine de conférences générales données par des chercheurs de renom international, et des séances de communications par affiches, occasions privilégiées de rencontres et d'échanges. Les exposés ont porté sur des sujets particulièrement actifs au niveau national et international, avec un accent sur des thèmes importants pour la région toulousaine : contrôle cohérent, optique et nanosciences, optique et astronomie, sans oublier la traditionnelle rubrique phénomènes fondamentaux, éclectique pour ne pas dire hétéroclite, mais si représentative d'une des ambitions de COLOQ qui est d'offrir à ses participants une

  4. Préface

    Science.gov (United States)

    Ouerdane, Youcef; Laporte, Pierre

    2005-06-01

    L'objectif de la série de colloques UVX est de réunir, au rythme d'une fois tous les deux ans, les scientifiques et industriels travaillant dans le domaine du développement des sources de photon de grande énergie (UV, VUV, et X) et de leurs applications. En particulier cette manifestation est l'occasion de faire se rencontrer une communauté très pluridisciplinaire (physique, chimie, biologie, sciences de l'univers) liée à des domaines en forte évolution technologique (lasers et rayonnement synchrotron notamment). Le colloque UVX 2004 s'est tenu au Palais des Congrès de Saint-Étienne (42000) du 7 au 11 juin 2004. La période écoulée depuis l'édition précédente (Oléron 2002) a été particulièrement active dans tous les domaines concernés : grands projets de sources, méthodes de diagnostic au sens large. Une nouvelle fois on constate que le bref et l'ultra-bref ont une place privilégiée, qu'il s'agisse du travail sur les accélérateurs ou sur les lasers qui, bien sûr, dans la course aux temps courts remportent la palme avec la présence de spécialistes du domaine attoseconde. La communauté représentée a la chance d'être en prise directe avec de très grands projets en phase active de réalisation comme le Laser Megajoule (LMJ), la source SOLEIL, et un projet d'ampleur plus modeste mais remarquable dans son domaine : la source LASERIX d'Orsay/Palaiseau. On pourra citer aussi le projet Arc en Ciel qui, lui, est encore au stade de sa définition. - SOLEIL, source de nouvelle génération de rayonnement synchrotron (plateau de Saclay) est dans une phase active de réalisation : achèvement de l'infrastructure en 2005 et injection du 1o faisceau dans l'anneau de stockage prévu également en 2005. Cette source devrait être la meilleure au monde dans le domaine VUV/X mous, tout en restant très polyvalente (brillance, accordabilité, structure temporelle, polarisation) et complémentaire de l'ESRF. Au final on disposera de 21 lignes de lumi

  5. ESO PR Highlights in 2006

    Science.gov (United States)

    2007-01-01

    Last year proved to be another exceptional year for the European organisation for ground-based astronomy. ESO should begin the New Year with two new member states: Spain (PR 05/06) and the Czech Republic (PR 52/06). ESO PR Highlights 2006 2006 was a year of renovation and revolution in the world of planets. A new Earth-like exoplanet has been discovered (PR 03/06) using a network of telescopes from all over the world (including the Danish 1.54-m one at ESO La Silla). It is not the only child of this fruitful year: thanks to the combined use of ESO's Very Large Telescope (VLT) and La Silla instruments, a surprising system of twin giant exoplanets was found (PR 29/06), and a trio of Neptune-like planets hosted by a nearby star were identified (PR 18/06). These results open new perspectives on the search for habitable zones and on the understanding of the mechanism of planet formation. The VISIR instrument on the VLT has been providing unique information to answer this last question, by supplying a high resolution view of a planet-forming disc (PR 36/06). There are not only new members in the planets' register: during the General Assembly of the International Astronomical Union held in Prague (Czech Republic), it was decided that Pluto is not a planet anymore but a 'dwarf planet'. Whatever its status, Pluto still has a satellite, Charon, whose radius and density have been measured more accurately by observing a rare occultation from different sites, including Cerro Paranal (PR 02/06). The scientific community dedicated 2006 to the great physicist James Clerk Maxwell (it was the 175th anniversary of the birth): without his electromagnetic theory of light, none of the astonishing discoveries of modern physics could have been achieved. Nowadays we can look at distant galaxies in great detail: the GIRAFFE spectrograph on the VLT revealed that galaxies 6 billion years ago had the same amount of dark matter relative to stars than nowadays (PR 10/06), while SINFONI gave an

  6. Préface

    Science.gov (United States)

    Hamieh, Tayssir

    2005-05-01

    Né simultanément à Mulhouse et à Beyrouth en 1996 dans le cadre d'une collaboraiion franco-libanaise sur une initiative personnelle de Monsieur Tayssir HAMIEH. le Colloque Franco-Libanais sur la Science des Matériaux (CSM), qui s'inscrit dans le cadre des relations étroites entre la France et le Liban, est très vite devenu une occasion très importante de rencontre entre scientifiques de haut niveau, non seulement, du contour méditerranéen mais également des pays européens, américains et arabes. La quatrieme édition CSM4 est une véritable réussite grâce à la participation des chercheurs confirmés dans tous les domaines des sciences de matériaux et venant de plusieurs pays tels que la France, I'Algérie, Le Liban, la Syrie, le Maroc, la Tunisie, l'Italie, l'Espagne, le Portugal, le Royaume Uni, les États-Unis, la Russie, l'Allemagne, le Japon et I'Inde ; pour présenter plus de 350 communications orales et par affiche et couvrant presque toutes les disciplines des systèmes des matériaux. Le choix des diffèrents thèmes du colloque sur la science des matériaux a été dicté par l'importance capitale de cette discipline dans notre civilisation moderne. En fait, les matériaux utilisés pour la fabrication artisanale ou industrielle d'objets, de produits et de systèmes ainsi que pour la réalisation de constructions et d'équipements ont de tout temps défini le niveau de notre civilisation technique. La réalisation des objectifs communs de notre monde en plein développement, pour ne pas dire en pleine mutation, est en grande partie tributaire de la mise au point de nouveaux matériaux et de procédés de transformation et d'assemblages nouveaux, présentant des performances et des qualités améliorées. Le colloque a illustré et traduit, de manière remarquables, l'excellente collaboration entre chercheurs libanais et français. Le partenariat est exemplaire par la qualité des laboratoires impliqués et par le niveau scientifique des r

  7. Political PR is dying. Long live business PR! / Ilyn Oleg

    Index Scriptorium Estoniae

    Oleg, Ilyn

    2005-01-01

    Vene suurima suhtekorraldusagentuuri Imageland Public Relations rahvusvaheliste suhete juhi hinnangul on Venemaal peamisteks probleemideks PR professionaalide vähesus, nende kehv haritus oma erialal, samuti vähene teadlikkus suhtekorralduse tähtsusest äris

  8. Erfolgsfaktoren unternehmerischer Krisen-PR

    OpenAIRE

    Scharr, Florian

    2006-01-01

    Ob "Peanuts", "Elchtest" oder "Hoechst-Störfall" - bei diesen bekannten Öffentlichkeitskrisen der letzten Jahre rief die mangelhafte Krisen-PR der betroffenen Unternehmen bei Medien und Bevölkerung mehr Empörung hervor als die originären Auslöser und potenzierte so den entstandenen Vertrauensverlust. Auch die sich gerade erst entwickelnde PR-Forschung bietet noch keine konkrete Hilfestellung zur Gestaltung von Krisen-PR. Mit dem bedeutenden Diskurs- und dadurch Realitätsgestaltungsmittel Pres...

  9. Présentation

    Directory of Open Access Journals (Sweden)

    Gregor Perko

    2011-12-01

    Full Text Available Au cours des dernières décennies où l’on assiste à une refondation de la morphologie, la discipline s’intéresse de plus en plus à des phénomènes « périphériques », « marginaux », « irréguliers » ou « extragrammaticaux », à des phénomènes n’appartenant pas aux « régions nodales » de la morphologie. Le présent numéro de Linguistica, premier numéro thématique de notre revue, réunit des études qui s’intéres- sent aux frontières internes et externes de la morphologie. La diversité et la richesse des thèmes abordés et des approches proposées témoignent d’un intérêt croissant que les linguistes, non pas uniquement les morphologues, portent à cette thématique. Les articles proposés s’articulent autour de cinq axes majeurs. Un premier axe rassemble les articles qui étudient les frontières entre différentes composantes de la morphologie. L’étude de Michel Roché examine les contraintes lexicales et morphophonologiques sur le paradigme des dérivés en –aie. Les résultats de son analyse remettent en question la notion de « règle de construction des lexèmes ». Irena Stramljič Breznik et Ines Voršič se penchent sur les néologismes de sport en slovène et essaient d’évaluer la productivité ou la créativité des procédés morphologiques en jeu. Dans une étude d’inspiration cognitiviste, Alexandra Bagasheva aborde l’hétérogénéité des verbes composés en anglais. En s’appuyant sur les données fournies par les para- digmes verbaux du maltais, Maris Camilleri examine la complexité du phénomène de classes flexionnelles basées sur les radicaux. Trois travaux concernent des procédés typiquement « extragrammaticaux » servant à former le plus souvent des occasionnalismes: Arnaud Léturgie tente de dégager des propriétés prototypiques de l’amalgamation lexicale en français, notamment celles de la création des mots-valises; Silvia Cacchiani analyse, à l

  10. 75 FR 74706 - Notice of Baseline Filings

    Science.gov (United States)

    2010-12-01

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Baseline Filings November 24, 2010. Centana Intrastate Pipeline, LLC. Docket No. PR10-84-001. Centana Intrastate Pipeline, LLC... applicants listed above submitted a revised baseline filing of their Statement of Operating Conditions for...

  11. Phase diagram of Pr-P system

    International Nuclear Information System (INIS)

    Mironov, K.E.

    1981-01-01

    An area of the Pr-P system, adjoining to the Pr ordinate, is plotted up by the DTA method. Presence of P solid solution in Pr is established. Data on thermal stability of PrP, PrP 2 , PrP 5 and PrP 7 are generalized. The diagram of phase transformations in Pr-P system is plotted up proceeding from the whole complex of the data, presented. A supposition is made on a possible formation of solid solutions between the highest polyphosphide and phosphorus [ru

  12. On the PR-algebras

    International Nuclear Information System (INIS)

    Lebedenko, V.M.

    1978-01-01

    The PR-algebras, i.e. the Lie algebras with commutation relations of [Hsub(i),Hsub(j)]=rsub(ij)Hsub(i)(i< j) type are investigated. On the basis of former results a criterion for the membership of 2-solvable Lie algebras to the PR-algebra class is given. The conditions imposed by the criterion are formulated in the linear algebra language

  13. Prácticas curriculares

    OpenAIRE

    García-Gordillo, Mar; Checa Godoy, Antonio; Gómez Mompart, Josep Lluis (Coordinador); Herrero Subías, Mónica (Coordinador)

    2015-01-01

    Esta ponencia pretende analizar, sucintamente, la situacion presente de las prácticas externas en las facultades de Comunicacion españolas. En una coyuntura sumamente peculiar, no solo para las prácticas de los titulos de Comunicacion, sino para todas las practicas universitarias, por los numerosos y a veces contradictorios cambios acaecidos en la legislacion reciente y los vaivenes normativos de las universidades; por la profunda crisis que viene atravesando el sector de la...

  14. Internet innovation in PR management

    Directory of Open Access Journals (Sweden)

    Ćalasan Veljko B.

    2014-01-01

    Full Text Available PR Management in the last decade has evolved to unimaginable limits . Its rapid 'evolution ' is directly linked to the development and innovation, above all, of internet communications - Cyber 'world'. Although the genesis of PR management was announced in a way, the changes of the modern PR management have led to a change in the general attitude towards this particular activity. It has become an indispensable factor for the success of every business or social enterprise. In the general run for internet contents with better quality, as an indispensable tool of PR management , for better use of cyberspace , a new generation of PR manager is created, who has almost no resemblance to the earlier managers before two decades. For these reasons, we believe that Internet innovation through the implementation of PR management, changed the world economy and society. Adjusting speed to this, virtual , yet very real world , is proportional to the speed of development of an economic system as a whole, or any company at the micro level , and society in general .Internet is not an important innovation itself to be sufficient to meet the form and define the essence of economic relations. Only its proper exploitation with the constant use of tested and more intense innovation is the only way to the overall success . The absence of the above, in our opinion, is a sure path to failure.

  15. PR Crisis Melalui Media Sosial

    Directory of Open Access Journals (Sweden)

    Gladys Carlina

    2017-07-01

    Full Text Available The background of this research is communication, new media, PR and PR Crisis. Fourth of this background has a close relationship, starting from communication, human in everyday life would require communication to receive and convey information, human can not be released from human life. The advancement of the times and the development of technology, causing people to communicate easily and the development of this era caused a new challenge for the PR and PR Crisis of a company, they should be able to maintain a positive image of the company in the minds of people. In this study using descriptive qualitative methodology, it contains many writings and drawings compared to the numbers. The purpose of this research is to know the strategy used by Pizza Hut in dealing with the issue of expired food. Penelitin results, social media is very positive impact on Pizza Hut in the recovery of food issues expired. The strategy used by the Pizza Hut Crisis PR is to utilize social media. Visible from the issue of expired food that disappeared in public and Pizza Hut restaurant until now crowded visited. Latar belakang dari penelitian ini yaitu komunikasi, media baru, PR dan PR Krisis. Keempat dari latar belakang ini mempunyai hubungan yang erat, dimulai dari komunikasi, manusia di dalam kehidupan sehari-hari tentunya memerlukan komunikasi untuk menerima dan menyampaikan informasi, manusia tidak bisa dilepaskan dari kehidupan manusia. Majunya perkembangan zaman dan perkembangan teknologi, menyebabkan manusia melakukan komunikasi dengan mudah dan perkembangan zaman ini menyebabkan adanya tantangan baru bagi para PR dan PR Krisis sebuah perusahaan, mereka harus bisa mempertahankan citra positif perusahaan di benak masyarakat. Dalam penelitian ini menggunakan metodologi kualitatif deksriptif, memuat banyak tulisan dan gambar dibandingkan angka-angka. Tujuan dari penelitian ini untuk mengetahui strategi yang digunakan oleh Pizza Hut dalam menangani isu makanan

  16. Deletion of Pr130 Interrupts Cardiac Development in Zebrafish

    Directory of Open Access Journals (Sweden)

    Jie Yang

    2016-11-01

    Full Text Available Protein phosphatase 2 regulatory subunit B, alpha (PPP2R3A, a regulatory subunit of protein phosphatase 2A (PP2A, is a major serine/threonine phosphatase that regulates crucial function in development and growth. Previous research has implied that PPP2R3A was involved in heart failure, and PR130, the largest transcription of PPP2R3A, functioning in the calcium release of sarcoplasmic reticulum (SR, plays an important role in the excitation-contraction (EC coupling. To obtain a better understanding of PR130 functions in myocardium and cardiac development, two pr130-deletion zebrafish lines were generated using clustered regularly interspaced short palindromic repeats (CRISPR/CRISPR-associated proteins (Cas system. Pr130-knockout zebrafish exhibited cardiac looping defects and decreased cardiac function (decreased fractional area and fractional shortening. Hematoxylin and eosin (H&E staining demonstrated reduced cardiomyocytes. Subsequent transmission electron microscopy revealed that the bright and dark bands were narrowed and blurred, the Z- and M-lines were fogged, and the gaps between longitudinal myocardial fibers were increased. Additionally, increased apoptosis was observed in cardiomyocyte in pr130-knockout zebrafish compared to wild-type (WT. Taken together, our results suggest that pr130 is required for normal myocardium formation and efficient cardiac contractile function.

  17. 48 CFR 49.601 - Notice of termination for convenience.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Notice of termination for convenience. 49.601 Section 49.601 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... termination for convenience. (See 49.402-3(g) for notice of termination for default.) ...

  18. 33 CFR 110.74c - Bahia de San Juan, PR.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bahia de San Juan, PR. 110.74c Section 110.74c Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.74c Bahia de San Juan, PR. The waters of San Antonio...

  19. 33 CFR 165.754 - Safety Zone: San Juan Harbor, San Juan, PR.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety Zone: San Juan Harbor, San Juan, PR. 165.754 Section 165.754 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Zone: San Juan Harbor, San Juan, PR. (a) Regulated area. A moving safety zone is established in the...

  20. Ten years experience of PR

    International Nuclear Information System (INIS)

    Dobak, Dobroslav

    2002-01-01

    This paper is an effort to summarize the way Slovak Bohunice NPP has gone through since the historical change in the Middle and Eastern European countries. Milestones on the way were: 1989 - change of political system; increasing interest of the public appearance; creation of work capacities - personnel and technical; education/exchange with Western countries; 1994 - establishment of Foreign Affairs and PR Department reporting directly to the NPP manager; application of various approaches, some observed from other countries; creation of utility policy - place of PR in the company; establishment of QA system - description of PR activities, goals, interlinks etc.; annual planning process including activities, finance, education (training). Lessons learned are: the NPP managers were not prepared; the public was not (and still is not) prepared to obtain specific information; education is crucial in opinion winning; simple overtake of methods from others is not always applicable; strategy and feedback are necessary. Special case was the early closure Bohunice V1 NPP

  1. 29 CFR 1625.4 - Help wanted notices or advertisements.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Help wanted notices or advertisements. 1625.4 Section 1625.4 Labor Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION AGE DISCRIMINATION IN EMPLOYMENT ACT Interpretations § 1625.4 Help wanted notices or advertisements. (a) Help wanted notices or advertisements may not contain...

  2. 48 CFR 6302.21 - Notice of hearing (Rule 21).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Notice of hearing (Rule 21... CONTRACT APPEALS RULES OF PROCEDURE 6302.21 Notice of hearing (Rule 21). The parties are given at least 15... appeals without unnecessary delay. Notices of hearings shall be promptly acknowledged by the parties. ...

  3. 12 CFR Appendix B to Part 228 - CRA Notice

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false CRA Notice B Appendix B to Part 228 Banks and... REINVESTMENT (REGULATION BB) Pt. 228, App. B Appendix B to Part 228—CRA Notice (a) Notice for main offices and... Federal Community Reinvestment Act (CRA), the Federal Reserve Board (Board) evaluates our record of...

  4. 12 CFR Appendix B to Part 25 - CRA Notice

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false CRA Notice B Appendix B to Part 25 Banks and... DEPOSIT PRODUCTION REGULATIONS Pt. 25, App. B Appendix B to Part 25—CRA Notice (a) Notice for main offices... the Federal Community Reinvestment Act (CRA), the Comptroller of the Currency evaluates our record of...

  5. 33 CFR 117.40 - Advance notice for drawbridge opening.

    Science.gov (United States)

    2010-07-01

    ... of the advanced notice for the drawbridge will be added to subpart B of this part. [USCG-2001-10881... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Advance notice for drawbridge... SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS General Requirements § 117.40 Advance notice for...

  6. 29 CFR 4245.3 - Notice of insolvency.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Notice of insolvency. 4245.3 Section 4245.3 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION INSOLVENCY, REORGANIZATION, TERMINATION, AND OTHER RULES APPLICABLE TO MULTIEMPLOYER PLANS NOTICE OF INSOLVENCY § 4245.3 Notice of...

  7. S1PR3 Signaling Drives Bacterial Killing and Is Required for Survival in Bacterial Sepsis.

    Science.gov (United States)

    Hou, JinChao; Chen, QiXing; Wu, XiaoLiang; Zhao, DongYan; Reuveni, Hadas; Licht, Tamar; Xu, MengLong; Hu, Hu; Hoeft, Andreas; Ben-Sasson, Shmuel A; Shu, Qiang; Fang, XiangMing

    2017-12-15

    Efficient elimination of pathogenic bacteria is a critical determinant in the outcome of sepsis. Sphingosine-1-phosphate receptor 3 (S1PR3) mediates multiple aspects of the inflammatory response during sepsis, but whether S1PR3 signaling is necessary for eliminating the invading pathogens remains unknown. To investigate the role of S1PR3 in antibacterial immunity during sepsis. Loss- and gain-of-function experiments were performed using cell and murine models. S1PR3 levels were determined in patients with sepsis and healthy volunteers. S1PR3 protein levels were up-regulated in macrophages upon bacterial stimulation. S1pr3 -/- mice showed increased mortality and increased bacterial burden in multiple models of sepsis. The transfer of wild-type bone marrow-derived macrophages rescued S1pr3 -/- mice from lethal sepsis. S1PR3-overexpressing macrophages further ameliorated the mortality rate of sepsis. Loss of S1PR3 led to markedly decreased bacterial killing in macrophages. Enhancing endogenous S1PR3 activity using a peptide agonist potentiated the macrophage bactericidal function and improved survival rates in multiple models of sepsis. Mechanically, the reactive oxygen species levels were decreased and phagosome maturation was delayed in S1pr3 -/- macrophages due to impaired recruitment of vacuolar protein-sorting 34 to the phagosomes. In addition, S1RP3 expression levels were elevated in monocytes from patients with sepsis. Higher levels of monocytic S1PR3 were associated with efficient intracellular bactericidal activity, better immune status, and preferable outcomes. S1PR3 signaling drives bacterial killing and is essential for survival in bacterial sepsis. Interventions targeting S1PR3 signaling could have translational implications for manipulating the innate immune response to combat pathogens.

  8. Interaction between 14-3-3β and PrP influences the dimerization of 14-3-3 and fibrillization of PrP106-126.

    Science.gov (United States)

    Han, Jun; Song, Qin-Qin; Sun, Peng; Zhang, Jin; Wang, Xu; Song, Juan; Li, Gong-Qi; Liu, Ying-Hui; Mei, Guo-Yong; Shi, Qi; Tian, Chan; Chen, Cao; Gao, Chen; Zhao, Bo; Dong, Xiao-Ping

    2014-02-01

    Proteins of the 14-3-3 family are universal participate in multiple cellular processes. However, their exact role in the pathogenesis of prion diseases remains unclear. In this study, we proposed that human PrP was able to form molecular complex with 14-3-3β. The domains responsible for the interactions between PrP and 14-3-3β were mapped at the segments of amino acid (aa) residues 106-126 within PrP and aa 1-38 within 14-3-3β. Homology modeling revealed that the key aa residues for molecular interaction were D22 and D23 in 14-3-3β as well as K110 in PrP. Mutations in these aa residues inhibited the interaction between the two proteins in vitro. Our results also showed that recombinant PrP encouraged 14-3-3β dimer formation, whereas PrP106-126 peptide inhibited it. Recombinant 14-3-3β disaggregated the mature PrP106-126 fibrils in vitro. Moreover, the PrP-14-3-3 protein complexes were observed in the brain tissues of normal and scrapie agent 263K infected hamsters. Colocalization of PrP and 14-3-3 was seen in the cytoplasm of human neuroblastoma cell line SH-SY5Y, as well as human cervical cancer cell line HeLa transiently expressing full-length human PrP. Our current data suggest the neuroprotection of PrPC and neuron damage caused by PrPSc may be associated with their functions of 14-3-3 dimerization regulation. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. 45 CFR 708.5 - Notice.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Notice. 708.5 Section 708.5 Public Welfare Regulations Relating to Public Welfare (Continued) COMMISSION ON CIVIL RIGHTS COLLECTION BY SALARY OFFSET FROM INDEBTED CURRENT AND FORMER EMPLOYEES § 708.5 Notice. (a) Deductions shall not be made unless the employee...

  10. Aplicação pré-colheita de reguladores vegetais visando retardar a maturação de ameixas 'Laetitia' Preharvest spraying with plant regulators aiming fruit maturity delay of 'Laetitia' plums

    Directory of Open Access Journals (Sweden)

    Cristiano André Steffens

    2009-08-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos de reguladores vegetais e da data de colheita sobre a maturação de ameixas 'Laetitia'. Os tratamentos avaliados foram: controle, aminoetoxivinilglicina (AVG; 125mg L-1, 1-metilciclopropeno (1-MCP; 70µg L-1 e ácido giberélico (GA3; 100mg.L-1, em combinação com duas datas de colheita (11/01/2007 e 25/01/2007. O GA3 foi aplicado 14 dias antes da primeira colheita, enquanto AVG e 1-MCP foram aplicados sete dias antes da primeira colheita. O experimento seguiu o delineamento em blocos ao acaso com quatro repetições. Os reguladores de crescimento, em geral, retardaram as alterações da cor da epiderme e mantiveram a textura dos frutos, com os maiores valores de resistências à compressão e à penetração de polpa. A força necessária para a ruptura da epiderme foi maior no tratamento com 1-MCP. O tratamento controle apresentou os maiores teores de sólidos solúveis (SS. O atraso na colheita reduziu a textura dos frutos, a acidez titulável e o teor de SS, mas proporcionou frutos mais vermelhos. No entanto, nos frutos tratados com os reguladores, a evolução da maturação foi retardada.The objective this research was to evaluate the effects of preharvest spraying with plant regulators and harvest date on the fruit maturity of 'Laetitia' plums. The treatments evaluated were: control (untreated, aminoethoxyvinylglycine [AVG; at 125mg (a.i. L-1], giberellic acid [GA3; at 100mg (a.i. L-1] and 1-Methylcyclopropene [1-MCP; at 70µg (a.i. L-1], combined with two harvest dates (01/11/2007 and 01/25/2007. The GA3 was sprayed 14 days before the first harvest, while AVG and 1-MCP were sprayed 7 days before the first harvest. The experiment followed the randomized block design with four replications. In general, the plant regulators delayed changes in skin color and preserved fruit texture, providing the highest resistances values for flesh compression and fresh penetration. The force for skin

  11. Comparison between TRMM PR and

    Indian Academy of Sciences (India)

    A comparison between TRMM PR rainfall estimates and rain gauge data from ANEEL and com- bined gauge/satellite ..... correctly the of the south Atlantic convergence ..... vapor, snow cover, and sea ice derived from SSM/I mea- surements ...

  12. Credibility Discourse of PR Agencies

    DEFF Research Database (Denmark)

    Isaksson, Maria; Jørgensen, Poul Erik Flyvholm

    2008-01-01

    to giving assurance of their expertise, trustworthiness and empathy, thus confirming our overall expectation that corporate credibility discourse is relatively uniform from a European perspective. However, contrary to our assumptions, the results of our study show that PR credibility discourse demonstrates...

  13. Profesi PR Identik dengan Perempuan ?

    Directory of Open Access Journals (Sweden)

    Neni Yulianita

    2004-09-01

    Full Text Available Profesi Public Relations (PR atau di Indonesia lebih dikenal dengan Humas, seringkali diidentikkan dengan profesi yang pantas dijabat oleh kaum perempuan. Adanya sebagian kalangan masyarakat yang menjudge bahwa profesi ini lebih tepat dijabat oleh kaum perempuan, dengan alasan profesi ini menuntut keterampilan, daya tarik, dan keluwesan. Dengan adanya anggapan tersebut,  tentu saja telah memberikan implikasi pada kaum laki-laki  sehingga menimbulkan keraguan pada mereka untuk menekuni bidang kajian PR/Humas di berbagai Perguruan Tinggi yang memiliki bidang ini. Ironisnya, user masih menganggap kaum laki-lakilah yang lebih tepat menjabat profesi PR, dengan anggapan antara lain bahwa laki-laki lebih energik, aktif, rasional, agresif, memiliki stamina atau fisik yang lebih kuat, dan memiliki kemampuan dalam penguasaan hardware atau teknologi komunikasi mutakhir yang lebih baik dibanding wanita yang dianggap lebih emosional, pasif, dan submisif. Anggapan ini tentu saja sangat merugikan perempuan,  walaupun hasil penelitian Robins dinyatakan bahwa,  “Tidak ada beda  laki-laki dan perempuan yang konsisten dalam kemampuan memecahkan masalah, keterampilan analitis, dorongan kompetitif, motivasi, sosiobilitas, atau kemampuan belajar”.  Untuk itu, dalam tulisan ini, penulis menyajikan jawaban apakah benar Profesi PR lebih tepat dijabat oleh Perempuan?

  14. ESO PR Highlights in 2000

    Science.gov (United States)

    2001-01-01

    At the beginning of the new millennium, ESO and its staff are facing the future with confidence. The four 8.2-m Unit Telescopes of the Very Large Telescope (VLT) are in great shape and the VLT Interferometer (VLTI) will soon have "first fringes". The intercontinental ALMA project is progressing well and concepts for extremely large optical/infrared telescopes are being studied. They can also look back at a fruitful and rewarding past year. Perhaps the most important, single development has been the rapid transition of the Very Large Telescope (VLT). From being a "high-tech project under construction" it has now become a highly proficient, world-class astronomical observatory. This trend is clearly reflected in ESO's Press Releases , as more and more front-line scientific results emerge from rich data obtained at this very efficient facility. There were also exciting news from several of the instruments at La Silla. At the same time, the ESO community may soon grow, as steps towards membership are being taken by various European countries. Throughout 2000, a total of 54 PR communications were made, with a large number of Press Photos and Video Clips, cf. the 2000 PR Index. Some of the ESO PR highlights may be accessed directly via the clickable image on the present page. ESO PR Photo 01/01 is also available in a larger (non-clickable) version [ JPEG: 566 x 566 pix - 112k]. It may be reproduced, if credit is given to the European Southern Observatory.

  15. 75 FR 77674 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2010-12-13

    ... Designation. 4. Proposed Rule--Part 740 of NCUA's Rules and Regulations, Accuracy of Advertising and Notice of...-bearing Transaction Accounts. 6. Tri-State Federal Credit Union's Appeal of Region II's Denial of its...

  16. 78 FR 6316 - Enterprise Texas Pipeline LLC; Notice of Compliance Filing

    Science.gov (United States)

    2013-01-30

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR13-23-000] Enterprise Texas Pipeline LLC; Notice of Compliance Filing Take notice that on January 17, 2013, Enterprise Texas Pipeline LLC filed a revised Statement of Operating Conditions to comply with a Commission order issued in...

  17. 76 FR 73618 - Enterprise Texas Pipeline LLC; Notice of Compliance Filing

    Science.gov (United States)

    2011-11-29

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. PR11-92-001] Enterprise Texas Pipeline LLC; Notice of Compliance Filing Take notice that on November 22, 2011, Enterprise Texas Pipeline LLC (Enterprise Texas) filed a revised Statement of Operating Conditions to comply with a...

  18. 75 FR 70732 - Enterprise Texas Pipeline LLC; Notice of Baseline Filing

    Science.gov (United States)

    2010-11-18

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-92-001] Enterprise Texas Pipeline LLC; Notice of Baseline Filing November 10, 2010. Take notice that on November 9, 2010, Enterprise Texas Pipeline LLC submitted a revised baseline filing of its Statement of Operating Conditions...

  19. 78 FR 13662 - Kansas Gas Service, a Division of ONEOK, Inc.; Notice of Petition

    Science.gov (United States)

    2013-02-28

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR13-18-001] Kansas Gas Service, a Division of ONEOK, Inc.; Notice of Petition Take notice that on February 6, 2013, Kansas Gas... fully detailed in the petition. Any person desiring to participate in this rate filing must file in...

  20. 78 FR 20314 - Jefferson Island Storage & Hub, L.L.C.; Notice of Filing

    Science.gov (United States)

    2013-04-04

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR13-44-000] Jefferson Island Storage & Hub, L.L.C.; Notice of Filing Take notice that on March 28, 2013, Jefferson Island Storage & Hub, L.L.C. filed to revise its Statement of Operating Conditions to among others, update...

  1. 75 FR 63452 - ONEOK Gas Storage, L.L.C.; Notice of Baseline Filing

    Science.gov (United States)

    2010-10-15

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-67-001] ONEOK Gas Storage, L.L.C.; Notice of Baseline Filing October 7, 2010. Take notice that on October 1, 2010, ONEOK Gas Storage, L.L.C. submitted a revised baseline filing of its Statement of Operating Conditions for services...

  2. 75 FR 26746 - ONEOK Westex Transmission, L.L.C.; Notice of Baseline Filing

    Science.gov (United States)

    2010-05-12

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-19-000] ONEOK Westex Transmission, L.L.C.; Notice of Baseline Filing May 5, 2010. Take notice that on April 29, 2010, ONEOK Westex Transmission, L.L.C. submitted its baseline filing of its Statement of Operating Conditions for transportation...

  3. 76 FR 20657 - Hattiesburg Industrial Gas Sales, L.L.C.; Notice of Filing

    Science.gov (United States)

    2011-04-13

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-102-001] Hattiesburg Industrial Gas Sales, L.L.C.; Notice of Filing Take notice that on April 1, 2011, Hattiesburg Industrial Gas Sales, L.L.C. (Hattiesburg) filed a revised Statement of Operating Conditions to comply with a...

  4. 78 FR 21929 - Hattiesburg Industrial Gas Sales, L.L.C.; Notice of Filing

    Science.gov (United States)

    2013-04-12

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR13-46-000] Hattiesburg Industrial Gas Sales, L.L.C.; Notice of Filing Take notice that on April 1, 2013, Hattiesburg Industrial Gas Sales, L.L.C. (Hattiesburg) filed to cancel its Statement of Operating Conditions including its Tariff...

  5. 77 FR 28375 - Eagle Rock Desoto Pipeline, L.P.; Notice of Petition for Rate Approval

    Science.gov (United States)

    2012-05-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-25-000] Eagle Rock Desoto Pipeline, L.P.; Notice of Petition for Rate Approval Take notice that on May 1, 2012, Eagle Rock Desoto Pipeline, L.P. (Desoto) filed a Rate Election pursuant to 284.123(b)(1) of the Commissions...

  6. 78 FR 11639 - Houston Pipe Line Company LP; Notice of Petition for Rate Approval

    Science.gov (United States)

    2013-02-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR13-31-000] Houston Pipe Line Company LP; Notice of Petition for Rate Approval Take notice that on February 1, 2013, Houston Pipe Line Company LP (HPL) filed for approval of rates for transportation service pursuant to section...

  7. 77 FR 21760 - Atmos Energy Colorado/Kansas Division; Notice of Baseline Filing

    Science.gov (United States)

    2012-04-11

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-19-000] Atmos Energy Colorado/Kansas Division; Notice of Baseline Filing Take notice that on March 30, 2012, Atmos Energy Colorado/Kansas Division (Atmos) submitted a baseline filing of their Statement of Operating Conditions for...

  8. 77 FR 28373 - Liberty Energy (Midstates) Corp.; Notice of Baseline Filing

    Science.gov (United States)

    2012-05-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-24-000] Liberty Energy (Midstates) Corp.; Notice of Baseline Filing Take notice that on April 30, 2012, Liberty Energy (Midstates) Corp. submitted a baseline filing of their Statement of Operating Conditions for services provided...

  9. 75 FR 68607 - CenterPoint Energy-Illinois Gas Transmission Company; Notice of Baseline Filing

    Science.gov (United States)

    2010-11-08

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-80-001] CenterPoint Energy--Illinois Gas Transmission Company; Notice of Baseline Filing November 1, 2010. Take notice that on October 28, 2010, CenterPoint Energy--Illinois Gas Transmission Company submitted a revised...

  10. 77 FR 23244 - Atmos Energy Colorado/Kansas Division; Notice of Revised Baseline Filing

    Science.gov (United States)

    2012-04-18

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR12-22-000] Atmos Energy Colorado/Kansas Division; Notice of Revised Baseline Filing Take notice that on April 10, 2012, Atmos Energy Colorado/Kansas Division (Atmos) filed a revised baseline filing of their Statement of Operating...

  11. 75 FR 51990 - CenterPoint Energy-Illinois Gas Transmission Company; Notice of Baseline Filing

    Science.gov (United States)

    2010-08-24

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-80-000] CenterPoint Energy--Illinois Gas Transmission Company; Notice of Baseline Filing August 17, 2010. Take notice that on August 12, 2010, the applicant listed above submitted their baseline filing of its Statement of Operating...

  12. 76 FR 2361 - Atmos Energy-Kentucky/Mid-States Division; Notice of Baseline Filing

    Science.gov (United States)

    2011-01-13

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-77-000] Atmos Energy--Kentucky/Mid-States Division; Notice of Baseline Filing January 5, 2011. Take notice that on December 30, 2010, Atmos Energy--Kentucky/Mid- States Division submitted a revised baseline filing of their...

  13. 77 FR 63311 - Acacia Natural Gas Corporation; Notice of Petition for Rate Approval

    Science.gov (United States)

    2012-10-16

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR13-1-000] Acacia Natural Gas Corporation; Notice of Petition for Rate Approval Take notice that on October 9, 2012, Acacia Natural Gas Corporation (Acacia) filed a Petition for Rate Approval pursuant to 284.123(b)(2) of the...

  14. 75 FR 27772 - Corning Natural Gas Corporation; Notice of Compliance Filing

    Science.gov (United States)

    2010-05-18

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR09-30-002] Corning Natural Gas Corporation; Notice of Compliance Filing May 11, 2010. Take notice that on May 3, 2010, Corning Natural Gas Corporation, (Corning) filed its Statement of section 311 Operating Conditions in compliance...

  15. 75 FR 28602 - Corning Natural Gas Corporation; Notice of Compliance Filing

    Science.gov (United States)

    2010-05-21

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR09-30-003] Corning Natural Gas Corporation; Notice of Compliance Filing May 17, 2010. Take notice that on May 10, 2010, Corning Natural Gas Corporation, (Corning) filed a corrected rate sheet to replace the rate sheet filed with its...

  16. 75 FR 33799 - EasTrans, LLC; Notice of Baseline Filing

    Science.gov (United States)

    2010-06-15

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-30-000] EasTrans, LLC; Notice of Baseline Filing June 8, 2010. Take notice that on June 4, 2010, EasTrans, LLC submitted a baseline filing of its Statement of Operating Conditions for services provided under section 311 of the...

  17. 75 FR 38802 - DCP Raptor Pipeline, LLC; Notice of Baseline Filing

    Science.gov (United States)

    2010-07-06

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-42-000] DCP Raptor Pipeline, LLC; Notice of Baseline Filing June 28, 2010. Take notice that on June 22, 2010, DCP Raptor Pipeline, LLC submitted a baseline filing of its Statement of Operating Conditions for services provided...

  18. 76 FR 46283 - Peoples Natural Gas Company LLC; Notice of Baseline Filing

    Science.gov (United States)

    2011-08-02

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR11-3-001] Peoples Natural Gas Company LLC; Notice of Baseline Filing Take notice that on July 20, 2011, Peoples Natural Gas... provided under Section 311 of the Natural Gas Policy Act of 1978 (NGPA). Any person desiring to participate...

  19. Pathogenesis of PR3-ANCA associated vasculitis

    NARCIS (Netherlands)

    Kallenberg, C. G. M.

    2008-01-01

    Wegener's Granulomatosis (WG) is closely associated with antineutrophil cytoplasmic autoantibodies (ANCA), particularly those directed to proteinase 3 (PR3). ANCA directed to myeloperoxidase (MPO) are associated with microscopic polyangiitis (MPA) and the Churg Strauss syndrome. PR3-ANCA associated

  20. Cancer de la próstata

    OpenAIRE

    Mendoza, Lupi Alejandro; Fundación Valle de Lili; Gutierrez, María Carolina; López Cardona, Arturo

    1997-01-01

    ¿Qué es la próstata?/¿Qué es la hiperplasia benigna de próstata?/El cáncer de próstata/¿Se hereda el cáncer de próstata?/¿Cómo se presenta y hacia donde se disemina el cáncer de próstata?/¿Cómo de descubre el cáncer de próstata?/¿Qué estudia la ultrasonografía transrectal o ecografía a través de recto?/¿Cómo se analizan los niveles de PSA?/¿Cómo se clasifica el cáncer de próstata?¿Cómo se determina la terapia más adecuada para un cáncer de próstata?/¿Cuáles son las opciones de tratamiento par...

  1. Competency profile of PR professional in sport

    OpenAIRE

    Gazdíková, Lenka

    2013-01-01

    Title: Competency profile of PR professional in sport Objective: The objective is to identify competencies required to a position of PR professional in sport. The aim of a survey is to verify the level of competencies which follows compiling competency profile and comparison with existing profile of PR specialist. Methods: The objective is achieved using survey, interview and analysis of competency models database. Results: The result of this paper is competency profile of PR professional in ...

  2. 17 CFR 248.126 - Delivery of opt out notices.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) REGULATIONS S-P AND S-AM Regulation S-AM: Limitations on Affiliate Marketing § 248.126 Delivery... Internet Web site at which the consumer obtained a product or service electronically and requires the... by e-mail from the affiliate providing the notice; or (3) Posts the notice on an Internet Web site...

  3. Bruken av nasjonale prøver

    DEFF Research Database (Denmark)

    Skov, Poul

    2010-01-01

    Artiklen beskriver resultater fra en omfattende evaluering af brugen af de nationale prøver i norsk grundskole. De nationale prøver er blevet modtaget positivt af mange kommuner og skoleledere og i mindre grad af lærerne. Resultaterne viser også, at prøverne er styrende for undervisningen, at bru...

  4. 18 CFR 157.9 - Notice of application and notice of schedule for environmental review.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Notice of application and notice of schedule for environmental review. 157.9 Section 157.9 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER NATURAL GAS ACT APPLICATIONS FOR CERTIFICATES OF PUBLIC...

  5. 75 FR 44934 - Notice of Request for Extension and Revision of a Currently Approved Information Collection

    Science.gov (United States)

    2010-07-30

    ... Approved Information Collection AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice and request... information collection. Abstract: Federal milk marketing order regulations authorized under the Agricultural... / Friday, July 30, 2010 / Notices#0;#0; [[Page 44934

  6. 78 FR 56744 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978

    Science.gov (United States)

    2013-09-13

    ... requiring special protection. The regulations establish such a permit system to designate Antarctic... NATIONAL SCIENCE FOUNDATION Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 AGENCY: National Science Foundation. ACTION: Notice of Permit Applications Received...

  7. 77 FR 38834 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978

    Science.gov (United States)

    2012-06-29

    ... requiring special protection. The regulations establish such a permit system to designate Antarctic... NATIONAL SCIENCE FOUNDATION Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 AGENCY: National Science Foundation. ACTION: Notice of permit applications received...

  8. 78 FR 59728 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978

    Science.gov (United States)

    2013-09-27

    ... requiring special protection. The regulations establish such a permit system to designate Antarctic... NATIONAL SCIENCE FOUNDATION Notice of Permit Applications Received Under the Antarctic... Foundation (NSF) is required to publish a notice of permit applications received to conduct activities...

  9. Tevfik Fikret Evreninde Gözden Kaçan Bir Küçük Kitap: Fuad Köprülü’nün “Tevfik Fikret ve Ahlâkı” A Minor Book That Escapes Notice In The World Of Tevfik Fikret: Fuad Köprülü’s “Tevfik Fikret And His Ethics”

    Directory of Open Access Journals (Sweden)

    Fatih ARSLAN

    2012-12-01

    Full Text Available Fikret, one of the volunteer soldiers of the tragic, is a sincere poet who is trying to soften the world of alteration, paradox and discrepancy with rear anxiety crises. He has transferred all the traumas he experienced in terms of social, psychological, physical and status into his stanzas sincerely. In spite of the elapsed time, his standing in an extent that cannot be exceeded in Turkish poetry should be mainlyanalyzed from that lyrical point of view. You feel and sense the mostsentimental weeping and cries of “ The Civilization of Tear” in Fikret’spoem. Both in his period and later, with different reasons, tens ofresearches and writings have been written up about him. One of thosewritings belongs to Fuat Köprülü who depicts his perception of poetry ina social structure again, because of unfair news aroused about him.The review that was published in 1918 as a minor book has acharacteristic of a quite original text for the studies on Fikret. The initialperiods of Turkish literature in fixing many of the original "Köprülü","Servet-i Fünun" the poet of the most complex in terms of literature,beyond the rhetoric of Turkish literature was an important work on. Thetext is short but extremely serious observations. Accompanied byexamples of the concepts of morality and value dimensions used inpoetry, which is looking for the answer to the question of the mostimportant problems Köprülü state. Tried to read the value from theworld of the poet's world. Readings of the text up to date, or is notpushed Tevfik Fikret a serious shortcoming in the name ofinvestigations. This study is primarily functional reading of the text tomake a solid effort and the continuation of the purpose of Fikret seeksto examine the source of. Türk şiirinde trajiğin gönüllü erlerinde olan Fikret; değişim, yozlaşma, çelişki ve tutarsızlık dünyasını artçı tedirginlik krizleriyle yumuşatmaya çalışan samimi bir şairdir. Uğradığı sosyal

  10. Protein misfolding cyclic amplification induces the conversion of recombinant prion protein to PrP oligomers causing neuronal apoptosis.

    Science.gov (United States)

    Yuan, Zhen; Yang, Lifeng; Chen, Baian; Zhu, Ting; Hassan, Mohammad Farooque; Yin, Xiaomin; Zhou, Xiangmei; Zhao, Deming

    2015-06-01

    The formation of neurotoxic prion protein (PrP) oligomers is thought to be a key step in the development of prion diseases. Recently, it was determined that the sonication and shaking of recombinant PrP can convert PrP monomers into β-state oligomers. Herein, we demonstrate that β-state oligomeric PrP can be generated through protein misfolding cyclic amplification from recombinant full-length hamster, human, rabbit, and mutated rabbit PrP, and that these oligomers can be used for subsequent research into the mechanisms of PrP-induced neurotoxicity. We have characterized protein misfolding cyclic amplification-induced monomer-to-oligomer conversion of PrP from three species using western blotting, circular dichroism, size-exclusion chromatography, and resistance to proteinase K (PK) digestion. We have further shown that all of the resulting β-oligomers are toxic to primary mouse cortical neurons independent of the presence of PrP(C) in the neurons, whereas the corresponding monomeric PrP were not toxic. In addition, we found that this toxicity is the result of oligomer-induced apoptosis via regulation of Bcl-2, Bax, and caspase-3 in both wild-type and PrP(-/-) cortical neurons. It is our hope that these results may contribute to our understanding of prion transformation within the brain. We found that β-state oligomeric PrPs can be generated through protein misfolding cyclic amplification (PMCA) from recombinant full-length hamster, human, rabbit, and mutated rabbit PrP. β-oligomers are toxic to primary mouse cortical neurons independent of the presence of PrP(C) in the neurons, while the corresponding monomeric PrPs were not toxic. This toxicity is the result of oligomers-induced apoptosis via regulation of Bcl-2, Bax, and caspase-3. These results may contribute to our understanding of prion transformation within the brain. © 2015 International Society for Neurochemistry.

  11. 78 FR 67084 - Drawbridge Operation Regulation; Broad Creek, Laurel, DE

    Science.gov (United States)

    2013-11-08

    ...-AA09 Drawbridge Operation Regulation; Broad Creek, Laurel, DE AGENCY: Coast Guard, DHS. ACTION: Notice....25, both at Laurel, DE. The proposed new rule would change the current regulation by requiring a..., mile 8.2, all at Laurel, shall open on signal if at least 48 hours notice is given. Previous regulation...

  12. Isothermal sections of the state diagram for the Pr-Ni-Ge system at 870 (0-0,5Pr) and 670 K (0,5-1Pr)

    International Nuclear Information System (INIS)

    Fedyna, M.F.; Pecharskij, V.K.; Bodak, O.I.

    1987-01-01

    Method of X-ray phase and microstructural analyses were used to study Pr-Ni-Ge ternary system at 870K (0-0.50 at.fractions of Pr) and 670K (0.50-1.00 at.fractions of Pr). 11 ternary compounds exist in the system: Pr 1-x (NiGe) 13 (x=0.24), PrNi 2 Ge 2 , Pr 2 Ni 3 Ge 5 , PrNiGe 3 , Pr 2 NiGe 6 , Pr 3 Ni 4 Ge 4 , PrNi (1-x) Ge 2 (x=0.33), PrNiGe, Pr(NiGe) 2-x (x=0.14), Pr 3 NiGe 2 , ∼Pr 5 NiGe 4 . Crystal structure was determined for seven ternary compounds

  13. Behavioral abnormalities in prion protein knockout mice and the potential relevance of PrPc for the cytoskeleton

    Science.gov (United States)

    The cellular prion protein (PrPC) is a highly conserved protein, which is anchored to the outer surface of the plasma membrane. Even though its physiological function has already been investigated in different cell or mouse models where PrPC expression is either up-regulated or depleted, its exact p...

  14. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use, administration...

  15. Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells.

    Science.gov (United States)

    Kawprasertsri, Sornsawan; Pietras, Richard J; Marquez-Garban, Diana C; Boonyaratanakornkit, Viroj

    2016-05-01

    Recent evidence has suggested a possible role for progesterone receptor (PR) in the progression of non-small cell lung cancer (NSCLC). However, little is known concerning roles of PR in NSCLC. PR contains a polyproline domain (PPD), which directly binds to the SH3 domain of signaling molecules. Because PPD-SH3 interactions are essential for EGFR signaling, we hypothesized that the presence of PR-PPD interfered with EGFR-mediated signaling and cell proliferation. We examined the role of PR-PPD in cell proliferation and signaling by stably expressing PR-B, or PR-B with disrupting mutations in the PPD (PR-BΔSH3), from a tetracycline-regulated promoter in A549 NSCLC cells. PR-B dose-dependently inhibited cell growth in the absence of ligand, and progestin (R5020) treatment further suppressed the growth. Treatment with RU486 abolished PR-B- and R5020-mediated inhibition of cell proliferation. Expression of PR-BΔSH3 and treatment with R5020 or RU486 had no effect on cell proliferation. Furthermore, PR-B expression but not PR-BΔSH3 expression reduced EGF-induced A549 proliferation and activation of ERK1/2, in the absence of ligand. Taken together, our data demonstrated the significance of PR extranuclear signaling through PPD interactions in EGFR-mediated proliferation and signaling in NSCLC. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  16. Photoemission of heavy fermion superconductor PrOs4Sb12 and other Pr compounds

    International Nuclear Information System (INIS)

    Imada, S.; Yamasaki, A.; Sekiyama, A.; Settai, R.; Onuki, Y.; Suga, S.; Sugawara, H.; Sato, H.; Ochiai, A.

    2004-01-01

    Full text: Strongly correlated electronic states due to Pr 4f electrons found in several Pr compounds have recently been attracting much attention. The Pr 4f electrons are much more localized than in Ce due to the lanthanoid contraction. Therefore, the number of the Pr systems that show strong electron correlation is much smaller than Ce systems. We will present a comparative study of Pr 4f electronic states in such systems as the heavy fermion superconductor PrOs 4 Sb 12 , the Kondo system PrSn 3 and the localized 4f systems Pr 4 X 3 (X = Sb and Bi). The Pr 4f electronic state was probed by means of the Pr 3d → 4f resonant photoemission (RPES). Because the kinetic energy (E K ) of the photoelectrons is as high as ∼ 900 eV, this method is much more bulk sensitive than the 4d → 4f RPES with E K ∼ 100 eV. The energy resolution could be set to about 100 meV by utilizing the soft X-rays from BL25SU in SPring-8 and the SCIENTA SES-200 analyzer. The Pr 4f excitation spectrum of PrSn 3 was found to show a very strong intensity at the Fermi level (E F ). This can be interpreted as the Kondo resonance which has been observed in the Kondo Ce and Yb compounds. In the Pr 4f spectrum of the heavy fermion superconductor PrOs 4 Sb 12 , the intensity at E F was smaller than in PrSn 3 . This clearly shows that the Kondo temperature (T K ) is much lower in PrOs 4 Sb 12 than in PrSn 3 . We have further found a strong excitation energy dependence in the RPES line shape. In the case of Pr 4 X 3 (X = Sb and Bi), the intensity at E B was much smaller than PrSn 3 and PrOs 4 Sb 12 , which is consistent with the localized character of Pr 4f electrons in Pr 4 X 3 . The Pr 4f spectra of these localized systems are qualitatively well reproduced by a cluster model calculation that takes into account the hybridization between the Pr 4f orbital and the conduction and valence bands made up by the X p and Pr 5d states

  17. Identification and expression analysis of a pathogenresponsive PR ...

    African Journals Online (AJOL)

    related (PR) proteins. PR-1 genes represent the first identified PR gene family. Most members of PR-1 gene family are not inducible by pathogen attacks. In this study, we identified a pathogen-responsive PR-1 gene designated as VqPR-1 ...

  18. Quelle préposition ?

    CERN Document Server

    Grevisse, Maurice

    1996-01-01

    Pour bien parler ou bien écrire, il faut avant tout posséder un bon vocabulaire, puis savoir bien remuer les mots, leur faire exprimer quelque chose et agencer adroitement les propositions. Il faut aussi - et cela n'est pas négligeable - amener congrûment les divers compléments des noms, des adjectifs ou des verbes ; quand ces compléments sont de construction indirecte, c'est-à-dire quand ils doivent être introduits par une préposition, on hésite parfois sur la bonne manière de les accrocher. Ne pas négliger le bon choix! Cela ne crée pas le style, sans doute, mais peut, pour une part, témoigner de sa bonne qualité.

  19. 75 FR 39244 - Arizona Public Service Company, Sequent Energy Management, L.P.; Notice of Joint Petition for...

    Science.gov (United States)

    2010-07-08

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-45-000] Arizona Public Service Company, Sequent Energy Management, L.P.; Notice of Joint Petition for Clarification, or in the Alternative, Request for Limited Waiver June 30, 2010. Take notice that on June 25, 2010, Arizona Public...

  20. Parimad suhtekorraldusteod konkursil Baltic PR Awards

    Index Scriptorium Estoniae

    2012-01-01

    Balti riikide suhtekorraldusliidud koostöös Rahvusvahelise Avalike Suhete Assotsiatsiooniga (IPRA) korraldavad 2001. aastast iga aasta kommunikatsioonijuhtimisalast auhinnakonkurssi Baltic PR Awards

  1. Thermodynamic assessment of the Pr-Zn binary system

    International Nuclear Information System (INIS)

    Huang, X.M.; Liu, L.B.; Zhang, L.G.; Jia, B.R.; Jin, Z.P.; Zheng, F.

    2008-01-01

    On the basis of available experimental data of phase diagram and thermodynamic properties, the Pr-Zn binary system has been optimized using the CALPHAD approach. The phases, including liquid and bcc A 2(βPr) were treated as substitutional solutions, while the intermetallic compounds, including PrZn, PrZn 2 , PrZn 3 , Pr 3 Zn 11 , Pr 13 Zn 58 , Pr 3 Zn 22 , Pr 2 Zn 17 and PrZn 11 were modeled as stoichiometric compounds. As the result of optimization, a set of self-consistent thermodynamic parameters has been obtained, which can be used to reproduce the reported experimental data

  2. 48 CFR 42.801 - Notice of intent to disallow costs.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Notice of intent to disallow costs. 42.801 Section 42.801 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Disallowance of Costs 42.801 Notice of...

  3. 76 FR 8651 - Special Local Regulation; Mavericks Surf Competition, Half Moon Bay, CA

    Science.gov (United States)

    2011-02-15

    ... provided to the public via broadcast notice to mariners, as well as through advertising on local media... regulate navigation for a limited time. Finally, the Public Broadcast Notice to Mariners will notify the... (iv) the maritime public will be advised in advance of this regulated area via Broadcast Notice to...

  4. PrP Conformational Transitions Alter Species Preference of a PrP-specific antibody

    NARCIS (Netherlands)

    Zou, W.Q.; Langeveld, J.P.M.; Xiao, X.; Chen, S.; McGeer, P.L.; Yuan, J.; Payne, M.C.; Kang, H.E.; McGeehan, J.M.; Sy, M.S.; Greenspan, N.S.; Kaplan, D.; Wang, G.X.; Parchi, P.; Hoover, E.A.; Kneale, G.; Telling, G.; Surewicz, W.; Kong, Q.; Guo, J.

    2010-01-01

    The epitope of the 3F4 antibody most commonly used in human prion disease diagnosis is believed to consist of residues Met-Lys-His-Met (MKHM) corresponding to human PrP-(109–112). This assumption is based mainly on the observation that 3F4 reacts with human and hamster PrP but not with PrP from

  5. Suured prügifirmad valmistuvad prügipuuduseks / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2010-01-01

    Ragn-Sells ja Adelan Prügiveod soovivad luba jäätmete pikaajaliseks vaheladestamiseks Tallinna piiril. Ragn-Sells saaks jäätmekütusetehase planeerimise ja ehitamise ajal endale koguda ligi 35 000 t segaolmejäätmeid aastas, Adelan Prügiveod sooviks ladestada ligi 50 000 t prügi aastas

  6. 20 CFR 901.53 - Notice of suspension, termination or resignation of enrollment.

    Science.gov (United States)

    2010-04-01

    ... ACTUARIES REGULATIONS GOVERNING THE PERFORMANCE OF ACTUARIAL SERVICES UNDER THE EMPLOYEE RETIREMENT INCOME... enrollment of an actuary, the Executive Director shall give notice thereof to appropriate officers and...

  7. 78 FR 31551 - Federal Acquisition Regulation; Submission for OMB Review; Commerce Patent Regulations

    Science.gov (United States)

    2013-05-24

    ...; Submission for OMB Review; Commerce Patent Regulations AGENCIES: Department of Defense (DOD), General... collection requirement concerning Department of Commerce patent regulations. A notice was published in...- 0095, Commerce Patent Regulations, by any of the following methods: Regulations.gov : http://www...

  8. 48 CFR 552.217-71 - Notice Regarding Option(s).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Notice Regarding Option(s... Notice Regarding Option(s). As prescribed in 517.208(b), insert the following provision: Notice Regarding Option(s) (NOV 1992) The General Services Administration (GSA) has included an option to [Insert...

  9. 7 CFR 319.24-4 - Notice of arrival of corn by permittee.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Notice of arrival of corn by permittee. 319.24-4... HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Corn Diseases Regulations Governing Entry of Indian Corn Or Maize § 319.24-4 Notice of arrival of corn by permittee. Immediately upon...

  10. 7 CFR 91.44 - Charges on overdue accounts and issuance of delinquency notices.

    Science.gov (United States)

    2010-01-01

    ... delinquency notices. 91.44 Section 91.44 Agriculture Regulations of the Department of Agriculture (Continued... Charges on overdue accounts and issuance of delinquency notices. (a) Accounts are considered overdue if... laboratory service will not be performed for any applicant with a notice of delinquency. (d) Applicants with...

  11. PrEP (Pre-Exposure Prophylaxis) 101

    Science.gov (United States)

    ... than 70%. Your risk of getting HIV from sex can be even lower if you combine PrEP with condoms and other prevention methods. Download PrEP 101 Consumer Info Sheet Vital Signs Fact Sheet on Daily Pill Can Prevent HIV (PrEP) Expand All Collapse All Video Introductions to PrEP What is PrEP? A Brief ...

  12. 78 FR 39829 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-07-02

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments...: Title: Reporting of Nonpayroll Withheld Tax Liabilities. OMB Number: 1545-1413. Regulation Project...

  13. 31 CFR 309.6 - Public notice of offering.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Public notice of offering. 309.6 Section 309.6 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL... Public notice of offering. When Treasury bills are to be offered, tenders therefor will be invited...

  14. 7 CFR 319.8-4 - Notice of arrival.

    Science.gov (United States)

    2010-01-01

    ... for the Plant Protection and Quarantine Programs, a notice of such arrival, on a form provided for... 7 Agriculture 5 2010-01-01 2010-01-01 false Notice of arrival. 319.8-4 Section 319.8-4 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE...

  15. 29 CFR 1922.5 - Notice of investigational hearings.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Notice of investigational hearings. 1922.5 Section 1922.5 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION... WORKERS' COMPENSATION ACT § 1922.5 Notice of investigational hearings. The Chairman of the Board shall...

  16. 75 FR 69464 - Manufacturer of Controlled Substances; Notice of Application

    Science.gov (United States)

    2010-11-12

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on July 16, 2009, Cerilliant Corporation, 811 Paloma Drive, Suite A, Round Rock...

  17. 77 FR 2321 - Manufacturer of Controlled Substances; Notice of Application

    Science.gov (United States)

    2012-01-17

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on June 28, 2011, Cerilliant Corporation, 811 Paloma Drive, Suite A, Round Rock...

  18. 76 FR 36577 - Manufacturer of Controlled Substances; Notice of Application

    Science.gov (United States)

    2011-06-22

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on May 4, 2011, Boehringer Ingelheim Chemicals Inc., 2820 N. Normandy Drive...

  19. 75 FR 32506 - Manufacturer of Controlled Substances; Notice of Application

    Science.gov (United States)

    2010-06-08

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application Pursuant to Sec. 1301.33(a) of Title 21 of the Code of Federal Regulations (CFR), this is notice that on April 12, 2010, Boehringer Ingelheim Chemicals Inc., 2820 N. Normandy Drive...

  20. 26 CFR 1.854-2 - Notice to shareholders.

    Science.gov (United States)

    2010-04-01

    ... shall, upon notice by the Internal Revenue Service that the regulated investment company has failed to... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Notice to shareholders. 1.854-2 Section 1.854-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED...

  1. 76 FR 76710 - Merritt, Beck C.; Notice of Filing

    Science.gov (United States)

    2011-12-08

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6730-000] Merritt, Beck C.; Notice of Filing Take notice that on December 1, 2011, Beck C. Merritt submitted for filing, an..., 16 U.S.C. 825d (b) and Part 45 of Title 18 of the Code of Federal Regulations, 18 CFR part 45. Any...

  2. 31 CFR Appendix A to Part 132 - Model Notice

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Model Notice A Appendix A to Part 132 Money and Finance: Treasury Regulations Relating to Money and Finance PROHIBITION ON FUNDING OF UNLAWFUL INTERNET GAMBLING Pt. 132, App. A Appendix A to Part 132—Model Notice [Date] [Name of foreign sender or...

  3. 12 CFR Appendix A to Part 233 - Model Notice

    Science.gov (United States)

    2010-01-01

    ... FUNDING OF UNLAWFUL INTERNET GAMBLING (REGULATION GG) Part 233, App. A Appendix A to Part 233—Model Notice... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Model Notice A Appendix A to Part 233 Banks and... that your institution processed payments through our facilities for Internet gambling transactions...

  4. 21 CFR 1.90 - Notice of sampling.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Notice of sampling. 1.90 Section 1.90 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GENERAL ENFORCEMENT REGULATIONS Imports and Exports § 1.90 Notice of sampling. When a sample of an article offered for import has...

  5. 29 CFR 1905.20 - Notice of hearing.

    Science.gov (United States)

    2010-07-01

    ...-STEIGER OCCUPATIONAL SAFETY AND HEALTH ACT OF 1970 Hearings § 1905.20 Notice of hearing. (a) Service. Upon... 29 Labor 5 2010-07-01 2010-07-01 false Notice of hearing. 1905.20 Section 1905.20 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR...

  6. 29 CFR 801.6 - Notice of protection.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Notice of protection. 801.6 Section 801.6 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 General § 801.6 Notice of protection. Every employer subject to...

  7. 30 CFR 256.32 - Notice of sale.

    Science.gov (United States)

    2010-07-01

    ... bids shall be filed, and the place, date and hour at which bids shall be opened. The notice shall... conditions of the sale. (b) Tracts shall be offered for lease by competitive sealed bidding under conditions specified in the notice of lease sale and in accordance with all applicable laws and regulations. A...

  8. 29 CFR 4281.45 - Notices of insolvency benefit level.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Notices of insolvency benefit level. 4281.45 Section 4281.45 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION INSOLVENCY... MASS WITHDRAWAL Benefit Suspensions § 4281.45 Notices of insolvency benefit level. (a) Requirement of...

  9. 29 CFR 4245.5 - Notice of insolvency benefit level.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Notice of insolvency benefit level. 4245.5 Section 4245.5 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION INSOLVENCY, REORGANIZATION, TERMINATION, AND OTHER RULES APPLICABLE TO MULTIEMPLOYER PLANS NOTICE OF INSOLVENCY § 4245.5...

  10. 29 CFR 4245.4 - Contents of notice of insolvency.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Contents of notice of insolvency. 4245.4 Section 4245.4 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION INSOLVENCY, REORGANIZATION, TERMINATION, AND OTHER RULES APPLICABLE TO MULTIEMPLOYER PLANS NOTICE OF INSOLVENCY § 4245.4...

  11. Aspects of Pr3+ luminescence in solids

    International Nuclear Information System (INIS)

    Srivastava, A.M.

    2016-01-01

    A brief perspective on the influence of “host lattice-Pr 3+ ” interactions on the optical properties of the Pr 3+ ion in solids is presented. How the energy position of the Pr 3+ 4f 1 5d 1 configuration relative to the 1 S 0 , 3 P J and host lattice conduction band levels influences the Pr 3+ optical properties is highlighted by considering solids in which the 4f 1 5d 1 configuration (1) is energetically above the 1 S 0 level, (2) is energetically below the 1 S 0 level, (3) is energetically close to the 1 S 0 level, and (4) overlaps with the host lattice conduction band. - Highlights: • Spectroscopic properties of Pr 3+ in solids is examined. • The influence of Pr 3+ 4f 1 5d 1 energy position relative to the 4f 2 levels is discussed. • The effect of interaction between Pr 3+ 4f 1 5d 1 and host conduction level is illustrated. • The paper identifies potential commercial applications.

  12. 77 FR 4714 - Self-Regulation of Class II Gaming

    Science.gov (United States)

    2012-01-31

    ...: Notice of proposed rulemaking. SUMMARY: This action proposes to amend the NIGC's self-regulation regulations to tailor the self-regulating qualifying criteria to a tribe's regulation of class II gaming activity and more clearly define and streamline the self-regulation certification process. By tailoring the...

  13. Studies in the Crystalline Electric Field in Pr2 Al and Pr Al by the Inelastic Neutron Scattering Method

    International Nuclear Information System (INIS)

    Slisenko, V.I.; Ivanitskij, P.G.; Vasil'kevich, A.A.; Krotenko, V.T.; Majstrenko, A.N.

    1993-01-01

    Results of inelastic neutron scattering in polycrystalline Pr 2 Al and Pr Al are reported. The parameters of the crystal field Hamiltonian for the orthorhombic point symmetry of the Pr 3+ ions in Pr 2 Al and Pr Al are derived from neutron spectra. Using These parameters the magnetic contribution to the specific heat is calculated

  14. A PR-4 gene identified from Malus domestica is involved in the defense responses against Botryosphaeria dothidea.

    Science.gov (United States)

    Bai, Suhua; Dong, Chaohua; Li, Baohua; Dai, Hongyi

    2013-01-01

    Pathogenesis-related protein-4 (PR-4) family is a group of proteins with a Barwin domain in C-terminus and generally thought to be involved in plant defense responses. However, their detailed roles are poorly understood in defense of apple plant against pathogenic infection. In the present study, a new PR-4 gene (designated as MdPR-4) was identified from Malus domestica, and its roles in defense responses of apple were investigated. The open reading frame of MdPR-4 gene is of 447 bp encoding a protein of 148 amino acids with a Barwin domain in C-terminus and a signal peptide of 26 amino acids in N-terminus. Sequence and structural analysis indicated that MdPR-4 protein belongs to class II of PR-4 family. The high-level expression of MdPR-4 was observed in flowers and leaves as revealed by quantitative real time PCR. The temporal expression analysis demonstrated that MdPR-4 expression could be up-regulated by Botryosphaeria dothidea infection and salicylic acid (SA) or methyl jasmonate (MeJA) treatment, but suppressed by diethyldithiocarbamic acid (DIECA). In vitro assays, recombinant MdPR-4 protein exhibited ribonuclease activity specific for single strand RNA and significant inhibition to hyphal growth of three apple pathogenic fungi B. dothidea, Valsa ceratosperma and Glomerella cingulata. Moreover, the inhibition was reduced by the presence of 5'-ADP. Taken all together, the results indicate that MdPR-4 protein is involved in the defense responses of apple against pathogenic attack by directly inhibiting hyphal growth, and the inhibition is correlated with its ribonuclease activity, where as MdPR-4 expression is regulated by both SA and JA signaling pathway. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  15. Crystal structure of PrOHSO4

    International Nuclear Information System (INIS)

    Fahey, J.A.; Williams, G.J.B.; Haschke, J.M.

    1979-01-01

    PrOHSO 4 was prepared by hydrothermal reaction of Pr(OH) 3 with Pr 2 (SO 4 ) 3 x H 2 O at 450 to 500 0 C and 1,200 +- 200 atm water pressure. The space group is P2 1 /c; the cell parameters are a = 4.488, b = 12.495, c = 7.091 A, β = 111.08, Z = 4, d/sub x/ = 4.49 g/cm 3 . Atomic coordinates and anisotropic thermal parameters are tabulated. A stereoscopic protection of the cation coordination sphere is shown and discussed. 2 figures, 3 tables

  16. Genetic human prion disease modelled in PrP transgenic Drosophila.

    Science.gov (United States)

    Thackray, Alana M; Cardova, Alzbeta; Wolf, Hanna; Pradl, Lydia; Vorberg, Ina; Jackson, Walker S; Bujdoso, Raymond

    2017-09-20

    Inherited human prion diseases, such as fatal familial insomnia (FFI) and familial Creutzfeldt-Jakob disease (fCJD), are associated with autosomal dominant mutations in the human prion protein gene PRNP and accumulation of PrP Sc , an abnormal isomer of the normal host protein PrP C , in the brain of affected individuals. PrP Sc is the principal component of the transmissible neurotoxic prion agent. It is important to identify molecular pathways and cellular processes that regulate prion formation and prion-induced neurotoxicity. This will allow identification of possible therapeutic interventions for individuals with, or at risk from, genetic human prion disease. Increasingly, Drosophila has been used to model human neurodegenerative disease. An important unanswered question is whether genetic prion disease with concomitant spontaneous prion formation can be modelled in Drosophila We have used pUAST/PhiC31-mediated site-directed mutagenesis to generate Drosophila transgenic for murine or hamster PrP (prion protein) that carry single-codon mutations associated with genetic human prion disease. Mouse or hamster PrP harbouring an FFI (D178N) or fCJD (E200K) mutation showed mild Proteinase K resistance when expressed in Drosophila Adult Drosophila transgenic for FFI or fCJD variants of mouse or hamster PrP displayed a spontaneous decline in locomotor ability that increased in severity as the flies aged. Significantly, this mutant PrP-mediated neurotoxic fly phenotype was transferable to recipient Drosophila that expressed the wild-type form of the transgene. Collectively, our novel data are indicative of the spontaneous formation of a PrP-dependent neurotoxic phenotype in FFI- or CJD-PrP transgenic Drosophila and show that inherited human prion disease can be modelled in this invertebrate host. © 2017 The Author(s).

  17. PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection.

    Science.gov (United States)

    Marshall, Karen E; Hughson, Andrew; Vascellari, Sarah; Priola, Suzette A; Sakudo, Akikazu; Onodera, Takashi; Baron, Gerald S

    2017-01-15

    Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrP C ) influences PrP C misfolding into the disease-associated isoform, PrP res , as well as prion propagation and infectivity. GPI proteins are found in cholesterol- and sphingolipid-rich membrane regions called rafts. Exchanging the GPI anchor for a nonraft transmembrane sequence redirects PrP C away from rafts. Previous studies showed that nonraft transmembrane PrP C variants resist conversion to PrP res when transfected into scrapie-infected N2a neuroblastoma cells, likely due to segregation of transmembrane PrP C and GPI-anchored PrP res in distinct membrane environments. Thus, it remained unclear whether transmembrane PrP C might convert to PrP res if seeded by an exogenous source of PrP res not associated with host cell rafts and without the potential influence of endogenous expression of GPI-anchored PrP C To further explore these questions, constructs containing either a C-terminal wild-type GPI anchor signal sequence or a nonraft transmembrane sequence containing a flexible linker were expressed in a cell line derived from PrP knockout hippocampal neurons, NpL2. NpL2 cells have physiological similarities to primary neurons, representing a novel and advantageous model for studying transmissible spongiform encephalopathy (TSE) infection. Cells were infected with inocula from multiple prion strains and in different biochemical states (i.e., membrane bound as in brain microsomes from wild-type mice or purified GPI-anchorless amyloid fibrils). Only GPI-anchored PrP C supported persistent PrP res propagation. Our data provide strong evidence that in cell culture GPI anchor-directed membrane association of PrP C is required for persistent PrP res propagation, implicating raft microdomains as a location for conversion. Mechanisms of prion propagation, and what makes them transmissible, are poorly understood. Glycosylphosphatidylinositol (GPI) membrane anchoring of the prion protein (PrP C

  18. 76 FR 28243 - Sunshine Act; Notice of Agency Meeting

    Science.gov (United States)

    2011-05-16

    ...--Part 740 of NCUA's Rules and Regulations, Accuracy of Advertising and Notice of Insured Status. 2..., Alexandria, VA 22314-3428. STATUS: Closed. MATTERS TO BE CONSIDERED: 1. Insurance Appeal. Closed pursuant to...

  19. 15 CFR 2003.1 - Notice of public hearings.

    Science.gov (United States)

    2010-01-01

    ... UNITED STATES TRADE REPRESENTATIVE REGULATIONS OF TRADE POLICY STAFF COMMITTEE § 2003.1 Notice of public... generalized tariff preferences for the listed articles; (b) Whenever the Special Representative or the Deputy...

  20. Pesticide regulation, utilization, and retailers' selling practices in Trinidad and Tobago, West Indies: current situation and needed changes Regulación, utilización y prácticas de venta minorista de los pesticidas en Trinidad y Tobago, Indias Occidentales: situación actual y cambios necesarios

    Directory of Open Access Journals (Sweden)

    Lexley M. Pinto Pereira

    2007-08-01

    Full Text Available OBJECTIVE: To explore pesticide regulation in Trinidad and Tobago, and to ascertain pesticide utilization and retailers' selling practices on Trinidad, which is the larger of twin islands that constitute the republic of Trinidad and Tobago. METHODS: Between February and June 2005, agrochemical retailers in Trinidad were surveyed about the most frequently sold pesticides and their knowledge and practices of pesticide sale. The Poisons and Toxic Chemicals Control Board of the Ministry of Health informed on legislature. RESULTS: Of 107 actively trading licensed pesticide outlets, 97 participated (91% response rate in the survey. Currently only 2.9% (21 of 720 registered products from four chemical classes are frequently utilized. Paraquat, methomyl, and alpha-cypermethrin (respective trade names are Gramoxone, Lannate, and Fastac from World Health Organization (WHO Hazard Classes I and II, and glyphosate isopropylamine (Swiper, Class U are the most frequently purchased pesticides. Pet shops constitute 39.2% (38 of retail shops selling pesticides. No regulations guide pesticide sale to agriculturists, and children may purchase them. Inadequate human and technical resources render legislative controls ineffective and disciplinary action against offenders is weak. Extensive governmental resources are employed in legislative procedures and product approval for the very low, 2.9% utilization rate, negatively impacting on monitoring pesticide sales. The Poisons Information Centre (PIC does not liaise with the Poisons and Toxic Chemicals Control Board or provide educational interventions for the community. As a result of this survey, it was possible to develop the first database to include the chemical, brand, and colloquial names of pesticides used in Trinidad and Tobago; WHO classification of approved pesticides; manufacturers; packaging; and antidotes and their availability for use by the Board and health professionals in Trinidad. CONCLUSIONS: Urgent

  1. Thermoelectric power of PrMg3

    Science.gov (United States)

    Isikawa, Yosikazu; Somiya, Kazuya; Koyanagi, Huruto; Mizushima, Toshio; Kuwai, Tomohiko; Tayama, Takashi

    2010-01-01

    PrMg3 is supposed to be one of the strongly correlated electron systems originated from the hybridization between the Pr 4f and conduction electrons, because the gigantic electronic specific heat coefficient C/T was observed at low temperatures. However, a typical behaviour of - ln T dependence was not observed in the temperature dependence of the electrical resistivity. The thermoelectric power S is a powerful tool to investigate the density of states at the Fermi energy. We measured carefully the thermoelectric power of PrMg3 in the temperature range between 2 and 300 K. S is extremely small, ranged within ±1 μV/K over the whole temperature. The value of S/T at low temperature limit was also significantly smaller than expected from the specific heat results. We therefore conclude that the density of state at the Fermi level is not enhanced in PrMg3.

  2. Thermoelectric power of PrMg3

    International Nuclear Information System (INIS)

    Isikawa, Yosikazu; Somiya, Kazuya; Koyanagi, Huruto; Mizushima, Toshio; Kuwai, Tomohiko; Tayama, Takashi

    2010-01-01

    PrMg 3 is supposed to be one of the strongly correlated electron systems originated from the hybridization between the Pr 4f and conduction electrons, because the gigantic electronic specific heat coefficient C/T was observed at low temperatures. However, a typical behaviour of - ln T dependence was not observed in the temperature dependence of the electrical resistivity. The thermoelectric power S is a powerful tool to investigate the density of states at the Fermi energy. We measured carefully the thermoelectric power of PrMg 3 in the temperature range between 2 and 300 K. S is extremely small, ranged within ±1 μV/K over the whole temperature. The value of S/T at low temperature limit was also significantly smaller than expected from the specific heat results. We therefore conclude that the density of state at the Fermi level is not enhanced in PrMg 3 .

  3. Crystal Field Levels of Pr3+ in PrFeO3 and PrGaO3 Determined by Inelastic Neutron Scattering

    DEFF Research Database (Denmark)

    Feldmann, K.; Henning, K.; Kaun, L.

    1975-01-01

    The crystal field splitting of the 3H4 ground state of the Pr ion in PrFeO3 and PrGaO3 has been investigated by inelastic scattering of thermal neutrons. At several temperatures the transitions have been measured by TAS and TOF methods for polycrystalline PrFeO3 and by the TOF method...... for polycrystalline PrGaO3. Energy level schemes which are different for these materials are given....

  4. 48 CFR 49.601-2 - Letter notice.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Letter notice. 49.601-2 Section 49.601-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT... immediate complete spoilage of work-in-process having a definite commercial value, or (D) to prevent any...

  5. Phase diagrams of Pr-C system

    International Nuclear Information System (INIS)

    Eremenko, V.N.; Velikanova, T.Ya.; Gordijchuk, O.V.

    1988-01-01

    Results of the X-ray phase, metallographic and high-temperature differential thermal analysis are used for the first time to plot a diagram of the Pr-C system state. Carbides are formed in the system: Pr 2 C 3 with the bcc-structure of the Pu 2 C 3 type and with the period a 0 = 0.85722+-0.00026 within the phase region + 2 C 3 >, a 0 0.86078+-0.00016 nm - within the region 2 C 3 >+α-PrC 2 ; dimorphous PrC 2 : α-PrC 2 with the bct-structure of the CaC 2 type and periods a 0.38517+-0.00011, c 0 = 0.64337+-0.00019 nm; β-PrC 2 with the fcc-structure, probably, of KCN type. Dicarbide melts congruently at 2320 grad. C, forming eutectics with graphite at 2254+-6 grad. C and composition of 71.5% (at.)C. It is polymorphously transformed in the phase region 2 C 3 > + 2 > at 1145+-4 grad. C, and in the region 2 >+C at 1134+-4 grad. C. Sesquicarbide melts incongruently at 1545+-4 grad. C. The eutectic reaction L ↔ + 2 C 3 > occurs at 800+-4 grad. C, the eutectic composition ∼ 15% (at.)C. The temperature of the eutectoid reaction ↔ + 2 C 3 > is 675+-6 grad C. The limiting carbon solubility in β-Pr is about 8 and in α-Pr it is about 5% (at.)

  6. On the subgroups of PR groups

    International Nuclear Information System (INIS)

    Lebedenko, V.M.

    1979-01-01

    The subgroups of PR-groups are being studied, i.e., the subgroups of connected and simply connected nonabelian Lie groups, their Lie algebras being defined by the commuting relations of the type [Hsub(i), Hsub(j)] = rsub(ij)Hsub(i) (i 1 of PR-group G there exists such complementary subgroup G 2 and that group G is expanded in semidirect product G = G 1 xG 2 [ru

  7. WRKY transcription factors involved in PR-1 gene expression in Arabidopsis

    NARCIS (Netherlands)

    Hussain, Rana Muhammad Fraz

    2012-01-01

    Salicylic acid (SA) is involved in mediating defense against biotrophic pathogens. The current knowledge of the SA-mediated signaling pathway and its effect on the transcriptional regulation of defense responses are reviewed in this thesis. PR-1 is a marker gene for systemic acquired resistance

  8. Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6

    KAUST Repository

    Qureshi, Bilal M.; Schmidt, Andrea; Behrmann, Elmar; Bü rger, Jö rg; Mielke, Thorsten; Spahn, Christian M. T.; Heck, Martin; Scheerer, Patrick

    2018-01-01

    Isoprenylated proteins are associated with membranes and their inter-compartmental distribution is regulated by solubilization factors, which incorporate lipid moieties in hydrophobic cavities and thereby facilitate free diffusion during trafficking. Here we report the crystal structure of a solubilization factor, the prenyl-binding protein (PrBP/δ), at 1.81 Å resolution in its ligand-free apo-form. Apo-PrBP/δ harbors a preshaped, deep hydrophobic cavity, capacitating apo-PrBP/δ to readily bind its prenylated cargo. To investigate the molecular mechanism of cargo solubilization we analyzed the PrBP/δ-induced membrane dissociation of rod photoreceptor phosphodiesterase (PDE6). The results suggest that PrBP/δ exclusively interacts with the soluble fraction of PDE6. Depletion of soluble species in turn leads to dissociation of membrane-bound PDE6, as both are in equilibrium. This

  9. Mechanistic insights into the role of prenyl-binding protein PrBP/δ in membrane dissociation of phosphodiesterase 6

    KAUST Repository

    Qureshi, Bilal M.

    2018-01-02

    Isoprenylated proteins are associated with membranes and their inter-compartmental distribution is regulated by solubilization factors, which incorporate lipid moieties in hydrophobic cavities and thereby facilitate free diffusion during trafficking. Here we report the crystal structure of a solubilization factor, the prenyl-binding protein (PrBP/δ), at 1.81 Å resolution in its ligand-free apo-form. Apo-PrBP/δ harbors a preshaped, deep hydrophobic cavity, capacitating apo-PrBP/δ to readily bind its prenylated cargo. To investigate the molecular mechanism of cargo solubilization we analyzed the PrBP/δ-induced membrane dissociation of rod photoreceptor phosphodiesterase (PDE6). The results suggest that PrBP/δ exclusively interacts with the soluble fraction of PDE6. Depletion of soluble species in turn leads to dissociation of membrane-bound PDE6, as both are in equilibrium. This

  10. Photon cascade luminescence from Pr3+ ions in LiPrP4O12 polyphosphate

    International Nuclear Information System (INIS)

    Shalapska, T; Stryganyuk, G; Romanyshyn, Yu; Demchenko, P; Voloshinovskii, A; Trots, D; Gektin, A; Dorenbos, P

    2010-01-01

    The spectral-kinetic properties of luminescence from LiY 1-x Pr x P 4 O 12 (x = 1, 0.1) phosphors are studied in the 10-300 K temperature range upon excitation within the UV-VUV spectral range. The luminescence observed for LiPrP 4 O 12 at low temperatures is attributed to both intra-configurational 4f 2 → 4f 2 and inter-configurational 4f5d → 4f 2 radiative transitions of Pr 3+ . The temperature dependence of emission and the decay kinetics of Pr 3+ luminescence from LiY 1-x Pr x P 4 O 12 (x = 1, 0.1) phosphors are explained by temperature stimulated transitions from the 1 S 0 to the Pr 3+ 4f5d state. At low temperatures, the energy potential barrier between the 1 S 0 and 4f5d states is 0.014 eV for LiPrP 4 O 12 . The spectral overlap of the 1 S 0 and 4f5d states of Pr 3+ in LiY 0.9 Pr 0.1 P 4 O 12 determines the luminescence properties in the entire temperature range studied.

  11. Chapter 11 Unexpected Turns and Twists in Structure/Function of PR-Proteins that Connect Energy Metabolism and Immunity

    KAUST Repository

    Narasimhan, Meena L.; Bressan, Ray Anthony; D'Urzo, Matilde Paino; Jenks, Matthew A.; Mengiste, Tesfaye

    2009-01-01

    Innate immunity in plants is manifested by a complex array of antimicrobial processes that includes induction of sets of pathogenesis-related (PR) proteins. The availability of genomic data has made clear that each PR-protein family in a species is represented by several genes. Microarray data in public databases show that in most families, including the PR-5 family surveyed here, the expression of only few family members is defense associated. Genetic studies show that depending on their nutrient acquisition strategy, pathogens induce distinct but overlapping sets of PR genes, suggesting a connection to energy or resource allocation. PR-5 proteins have a clearly recognizable structure that is referred to as the thaumatin (THN) domain, which can be overlapped with mammalian Complement 1q-tumor necrosis factor (C1q-TNF) domains such as that of the mammalian hormone adiponectin. The occurrence of THN domain proteins is widespread. Similarities between THN domain proteins and mammalian C1q-TNF family proteins include their ligands and their subcellular locations. Osmotin (tobacco PR-5c) regulates energy balance signaling in mammalian cells by interaction with adiponectin receptors by a pathway that shares components with plant energy and stress signaling pathways. These data suggest additional roles for PR-5 proteins, as scaffolds and/or in signaling, particularly in regulating energy balance. © 2009 Elsevier Ltd. All rights reserved.

  12. Are PrP(C)s involved in some human myelin diseases? Relating experimental studies to human pathology.

    Science.gov (United States)

    Veber, Daniela; Scalabrino, Giuseppe

    2015-12-15

    We have experimentally demonstrated that cobalamin (Cbl) deficiency increases normal cellular prion (PrP(C)) levels in rat spinal cord (SC) and cerebrospinal fluid (CSF), and decreases PrP(C)-mRNA levels in rat SC. Repeated intracerebroventricular administrations of anti-octapeptide repeat-PrP(C)-region antibodies to Cbl-deficient (Cbl-D) rats prevent SC myelin lesions, and the administrations of PrP(C)s to otherwise normal rats cause SC white matter lesions similar to those induced by Cbl deficiency. Cbl positively regulates SC PrP(C) synthesis in rat by stimulating the local synthesis of epidermal growth factor (EGF), which also induces the local synthesis of PrP(C)-mRNAs, and downregulating the local synthesis of tumor necrosis factor(TNF)-α, thus preventing local PrP(C) overproduction. We have clinically demonstrated that PrP(C) levels are increased in the CSF of patients with subacute combined degeneration (SCD), unchanged in the CSF of patients with Alzheimer's disease and amyotrophic lateral sclerosis, and decreased in the CSF and SC of patients with multiple sclerosis (MS), regardless of its clinical course. We conclude that SCD (human and experimental) is a neurological disease due to excess PrP(C) without conformational change and aggregation, that the increase in PrP(C) levels in SCD and Cbl-D polyneuropathy and their decrease in MS CNS make them antipodian myelin diseases in terms of quantitative PrP(C) abnormalities, and that these abnormalities are related to myelin damage in the former, and impede myelin repair in the latter. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Prôtegis data

    Directory of Open Access Journals (Sweden)

    María Fernanda De la Ossa Archila

    2013-12-01

    Full Text Available El suministro de datos personales por los particulares se realiza casi a diario, por lo que es básico conocer quién tiene esos datos, cuáles son las medidas que adopta este sujeto para que dichos datos sean utilizados de manera correcta y para unos fines precisos para los cuales se han suministrado. La pregunta concreta que debe uno formularse es cómo se protegen los datos personales. Teniendo en cuenta lo anterior, en este artículo se hará un recuento de lo que ocurre en el contexto colombiano, en donde el legislador, por medio de la Ley 1581 de 2012 que fue sometida a control previo de constitucionalidad, reguló los derechos de los titulares de la información, los deberes de los responsables y encargados del tratamiento de la información suministrada y señaló de manera concreta cuál es la autoridad encargada para la vigilancia y control de una efectiva protección de los datos personales.

  14. Prôtegis data

    Directory of Open Access Journals (Sweden)

    María Fernanda De la Ossa Archila

    2013-12-01

    Full Text Available Throughout our lives, and almost daily, we provide our personal data to strangers in order to acquire goods, have access to different services or to carry on transactions within public or private entities. We find ourselves revealing our intimacy to the supermarket cashier, the saleswoman in a clothing store, a bank adviser, the State, among others. Therefore, we need to know who has this information, what are the measures taken to assure that the data is being used correctly and for the specific purposes for which it was supplied. The specific question that should be asked is how to protect personal data. Given the above, this article will illustrate about what happens in the Colombian context, where the1581 Act of 2012, which was subject to prior control of constitutionality, regulates the rights of holders of information, the duties of the Officers and Managers of treatment and the authority responsible for the supervision and control of effective protection of personal data.

  15. E-PR technologies in political party activities

    OpenAIRE

    Tereshchuk Vitaliy Ivanovych

    2016-01-01

    The article discusses the role of the Internet as an important communicative tool in the field of political PR. The article reviews the characteristics of PR-activities on the Internet and the features of e-PR in the political sphere. Particular attention is paid to the system of political party’s e-PR tools.

  16. Heregulin Co-opts PR Transcriptional Action Via Stat3 Role As a Coregulator to Drive Cancer Growth.

    Science.gov (United States)

    Proietti, Cecilia J; Izzo, Franco; Díaz Flaqué, María Celeste; Cordo Russo, Rosalía; Venturutti, Leandro; Mercogliano, María Florencia; De Martino, Mara; Pineda, Viviana; Muñoz, Sergio; Guzmán, Pablo; Roa, Juan C; Schillaci, Roxana; Elizalde, Patricia V

    2015-10-01

    Accumulated findings have demonstrated the presence of bidirectional interactions between progesterone receptor (PR) and the ErbB family of receptor tyrosine kinases signaling pathways in breast cancer. We previously revealed signal transducer and activator of transcription 3 (Stat3) as a nodal convergence point between said signaling pathways proving that Stat3 is activated by one of the ErbBs' ligands, heregulin (HRG)β1 via ErbB2 and through the co-option of PR as a signaling molecule. Here, we found that HRGβ1 induced Stat3 recruitment to the promoters of the progestin-regulated cell cycle modulators Bcl-XL and p21(CIP1) and also stimulated Stat3 binding to the mouse mammary tumor virus promoter, which carries consensus progesterone response elements. Interestingly, HRGβ1-activated Stat3 displayed differential functions on PR activity depending on the promoter bound. Indeed, Stat3 was required for PR binding in bcl-X, p21(CIP1), and c-myc promoters while exerting a PR coactivator function on the mouse mammary tumor virus promoter. Stat3 also proved to be necessary for HRGβ1-induced in vivo tumor growth. Our results endow Stat3 a novel function as a coregulator of HRGβ1-activated PR to promote breast cancer growth. These findings underscore the importance of understanding the complex interactions between PR and other regulatory factors, such as Stat3, that contribute to determine the context-dependent transcriptional actions of PR.

  17. Heregulin Co-opts PR Transcriptional Action Via Stat3 Role As a Coregulator to Drive Cancer Growth

    Science.gov (United States)

    Izzo, Franco; Díaz Flaqué, María Celeste; Cordo Russo, Rosalía; Venturutti, Leandro; Mercogliano, María Florencia; De Martino, Mara; Pineda, Viviana; Muñoz, Sergio; Guzmán, Pablo; Roa, Juan C.; Schillaci, Roxana

    2015-01-01

    Accumulated findings have demonstrated the presence of bidirectional interactions between progesterone receptor (PR) and the ErbB family of receptor tyrosine kinases signaling pathways in breast cancer. We previously revealed signal transducer and activator of transcription 3 (Stat3) as a nodal convergence point between said signaling pathways proving that Stat3 is activated by one of the ErbBs' ligands, heregulin (HRG)β1 via ErbB2 and through the co-option of PR as a signaling molecule. Here, we found that HRGβ1 induced Stat3 recruitment to the promoters of the progestin-regulated cell cycle modulators Bcl-XL and p21CIP1 and also stimulated Stat3 binding to the mouse mammary tumor virus promoter, which carries consensus progesterone response elements. Interestingly, HRGβ1-activated Stat3 displayed differential functions on PR activity depending on the promoter bound. Indeed, Stat3 was required for PR binding in bcl-X, p21CIP1, and c-myc promoters while exerting a PR coactivator function on the mouse mammary tumor virus promoter. Stat3 also proved to be necessary for HRGβ1-induced in vivo tumor growth. Our results endow Stat3 a novel function as a coregulator of HRGβ1-activated PR to promote breast cancer growth. These findings underscore the importance of understanding the complex interactions between PR and other regulatory factors, such as Stat3, that contribute to determine the context-dependent transcriptional actions of PR. PMID:26340407

  18. PrP N-terminal domain triggers PrPSc-like aggregation of Dpl

    International Nuclear Information System (INIS)

    Erlich, Paul; Cesbron, Jean-Yves; Lemaire-Vieille, Catherine; Curt, Aurelie; Andrieu, Jean-Pierre; Schoehn, Guy; Jamin, Marc; Gagnon, Jean

    2008-01-01

    Transmissible spongiform encephalopathies are fatal neurodegenerative disorders thought to be transmitted by self-perpetuating conformational conversion of a neuronal membrane glycoprotein (PrP C , for 'cellular prion protein') into an abnormal state (PrP Sc , for 'scrapie prion protein'). Doppel (Dpl) is a protein that shares significant biochemical and structural homology with PrP C . In contrast to its homologue PrP C , Dpl is unable to participate in prion disease progression or to achieve an abnormal PrP Sc -like state. We have constructed a chimeric mouse protein, composed of the N-terminal domain of PrP C (residues 23-125) and the C-terminal part of Dpl (residues 58-157). This chimeric protein displays PrP-like biochemical and structural features; when incubated in presence of NaCl, the α-helical monomer forms soluble β-sheet-rich oligomers which acquire partial resistance to pepsin proteolysis in vitro, as do PrP oligomers. Moreover, the presence of aggregates akin to protofibrils is observed in soluble oligomeric species by electron microscopy

  19. Tips for the PR Chairman for Education Associations. PR Bookshelf No. 2.

    Science.gov (United States)

    National Education Association, Washington, DC.

    This booklet is intended to aid leaders of local education associations in developing a continuing public relations (PR) program aimed at establishing and maintaining a favorable public image for teachers. Although it offers useful guidelines for developing a PR program, the booklet does not contain lists of specific things to do. Instead, it…

  20. La préservation, atout essentiel pour contrer la précarité des ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    La préservation, atout essentiel pour contrer la précarité des moyens de subsistance en ... Union mondiale pour la conservation de la nature et des ressources ... la recherche menée dans les domaines des sciences sociales, des sciences ...

  1. 75 FR 54226 - Proposed Collection; Comment Request for Notice 98-52 and REG-108639-99

    Science.gov (United States)

    2010-09-03

    ... Notice 98-52 and REG- 108639-99 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and... proposed rulemaking, REG-108639-99, Retirement Plans; Cash or Deferred Arrangements Under Section 401(k.... Regulation Project Number: REG-108639-99. Abstract: This notice provides guidance to plan administrators...

  2. 7 CFR 35.14 - Notice.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Notice. 35.14 Section 35.14 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... offers for shipment, any variety of vinifera species table grapes to any foreign destination in violation...

  3. 41 CFR 105-56.031 - Notice.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Notice. 105-56.031 Section 105-56.031 Public Contracts and Property Management Federal Property Management Regulations System... the amount of offset taken; (ii) The identity of the creditor agency identified by the disbursing...

  4. 41 CFR 105-56.021 - Notice.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Notice. 105-56.021 Section 105-56.021 Public Contracts and Property Management Federal Property Management Regulations System... description of the payment and the amount of offset taken; (ii) The identity of GSA as the creditor agency...

  5. 76 FR 77558 - Sunshine Act Meeting; Notice

    Science.gov (United States)

    2011-12-13

    ... LEGAL SERVICES CORPORATION Sunshine Act Meeting; Notice DATES: Date and Time: The Legal Services Corporation's Operations & Regulations Committee will meet December 16, 2011. The meeting will commence at 4 p... Bylaws necessitated by the DC Nonprofit Corporation Act of 2010. 3. Public comment. 4. Consider and act...

  6. 45 CFR 2490.111 - Notice.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Notice. 2490.111 Section 2490.111 Public Welfare Regulations Relating to Public Welfare (Continued) JAMES MADISON MEMORIAL FELLOWSHIP FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE JAMES MADISON MEMORIAL...

  7. 7 CFR 987.36 - Notice.

    Science.gov (United States)

    2010-01-01

    ... of communication to producers and handlers of the contents of each marketing policy report submitted... of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... RIVERSIDE COUNTY, CALIFORNIA Order Regulating Handling Marketing Policy § 987.36 Notice. The Committee shall...

  8. Pr-magnetism in the quasi-skutterudite compound PrFe2Al8.

    Science.gov (United States)

    Nair, Harikrishnan S; Ogunbunmi, Michael O; Kumar, C M N; Adroja, D T; Manuel, P; Fortes, D; Taylor, J; Strydom, A M

    2017-08-31

    The intermetallic compound PrFe 2 Al 8 that possesses a three-dimensional network structure of Al polyhedra centered at the transition metal element Fe and the rare earth Pr is investigated through neutron powder diffraction and inelastic neutron scattering in order to elucidate the magnetic ground state of Pr and Fe and the crystal field effects of Pr. Our neutron diffraction study confirms long-range magnetic order of Pr below [Formula: see text] K in this compound. Subsequent magnetic structure estimation reveals a magnetic propagation vector [Formula: see text] with a magnetic moment value of [Formula: see text]/Pr along the orthorhombic c-axis and evidence the lack of ordering in the Fe sublattice. The inelastic neutron scattering study reveals one crystalline electric field excitation near 19 meV at 5 K in PrFe 2 Al 8 . The energy-integrated intensity of the 19 meV excitation as a function of [Formula: see text] follows the square of the magnetic form factor of [Formula: see text] thereby confirming that the inelastic excitation belongs to the Pr sublattice. The second sum rule applied to the dynamic structure factor indicates only 1.6(2) [Formula: see text] evolving at the 19 meV peak compared to the 3.58 [Formula: see text] for free [Formula: see text], indicating that the crystal field ground state is magnetic and the missing moment is associated with the resolution limited quasi-elastic line. The magnetic order occurring in Pr in PrFe 2 Al 8 is counter-intuitive to the symmetry-allowed crystal field level scheme, hence, is suggestive of exchange-mediated mechanisms of ordering stemming from the magnetic ground state of the crystal field levels.

  9. Cu4Pr6(MoO4)11-Pr2(MoO4)3 system

    International Nuclear Information System (INIS)

    Arzumanyan, G.A.

    1982-01-01

    Existence boundaries and Dalton compositions (CuPr(MoO 4 ) 2 , CuPr 3 (MoO 4 ) 5 ) of solid solutions that in the mojority are of shcheelite dsitored structure have been determined in the Cu 4 Pr 6 (MoO 4 ) 11 -Pr 2 (MoO 4 ) 3 system. It has been revealed that regions of homogeneity near the CuPr(MoO 4 ) 2 composition have a horseshoeshaped profile

  10. Study of the atomic dynamics of nanoclusters Y2SiO5:Pr3+ by the confocal fluorescent microscopy

    International Nuclear Information System (INIS)

    Malyukin, Yu.V.; Zhmurin, P.N.; Syrkin, E.S.; Feodosyev, S.B.; Mamalui, M.A.

    2004-01-01

    The system under consideration consists of a Pr 3+ ion placed into a nanodimensional Y 2 SiO 5 crystal (∝20 nm), which rests on a glass substrate. The spectrum and attenuation of the fluorescence of the Pr 3+ ion have been studied by the method of confocal fluorescent microscopy. The rapid electron relaxation in J-multiplets of rare earth impurity ions split by the crystal field (for a usual bulk crystal τ∝10 -9 -10 -12 sec) is shown to be suppressed in the nanodimensional crystal of Y 2 SiO 5 :Pr 3+ . For the excited Stark components of 1 D 2 multiplet, the electron relaxation appears to be more than 10 4 times suppressed, while an average splitting of the 1 D 2 multiplet by the crystal field of ligands is 200 cm -1 . The observed phenomena strongly depends on the interaction of the Y 2 SiO 5 :Pr 3+ cluster with the substrate and the surrounding ('matrix'). Experimental results and theoretical calculations show the noticeable changes in the structure of vibrational spectrum and the density of vibrational states of the nanodimensional Y 2 SiO 5 :Pr 3+ crystal. (copyright 2004 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  11. The Novel Gene VpPR4-1 from Vitis pseudoreticulata Increases Powdery Mildew Resistance in Transgenic Vitis vinifera L.

    Science.gov (United States)

    Dai, Lingmin; Wang, Dan; Xie, Xiaoqing; Zhang, Chaohong; Wang, Xiping; Xu, Yan; Wang, Yuejin; Zhang, Jianxia

    2016-01-01

    Pathogenesis-related proteins (PRs) can lead to increased resistance of the whole plant to pathogen attack. Here, we isolate and characterize a PR-4 protein (VpPR4-1) from a wild Chinese grape Vitis pseudoreticulata which shows greatly elevated transcription following powdery mildew infection. Its expression profiles under a number of abiotic stresses were also investigated. Powdery mildew, salicylic acid, and jasmonic acid methyl ester significantly increased the VpPR4-1 induction while NaCl and heat treatments just slightly induced VpPR4-1 expression. Abscisic acid and cold treatment slightly affected the expression level of VpPR4-1. The VpPR4-1 gene was overexpressed in 30 regenerated V. vinifera cv. Red Globe via Agrobacterium tumefaciens-mediated transformation and verified by the Western blot. The 26 transgenic grapevines exhibited higher expression levels of PR-4 protein content than wild-type vines and six of them were inoculated with powdery mildew which showed that the growth of powdery mildew was repressed. The powdery mildew-resistance of Red Globe transformed with VpPR4-1 was enhanced inoculated with powdery mildew. Moreover, other powdery mildew resistant genes were associated with feedback regulation since VpPR4-1 is in abundance. This study demonstrates that PR-4 protein in grapes plays a vital role in defense against powdery mildew invasion.

  12. Optimization of Pr3+:ZBLAN fiber amplifiers

    DEFF Research Database (Denmark)

    Pedersen, B.; Miniscalco, J. W.; Quimby, R. S.

    1992-01-01

    Experimental parameters have been measured and used in a quantitative model of Pr3+-doped fluorozirconate fiber amplifiers. The optimum cutoff wavelength was determined to be 800 nm and the gain for 400 mW of pump was found to increase from 12 to 34 dB if the NA was increased from 0.15 to 0...

  13. Prøvetagning af grundvand

    DEFF Research Database (Denmark)

    Sørensen, Inga

    Bogen fokuserer på prøveatgning af grundvand og drikkevand til forskellige formål såsom undersøgelse af forurenede grunde, grundvandsmonitering samt produktion af drikkevand. Da grundvand i sagens natur findes under jordoverfladen, beskriver bogen også væsentlige forhold om hydrogeologi og...

  14. Mechanistic prospective for human PrPC conversion to PrPSc: Molecular dynamic insights

    OpenAIRE

    Nooshin Azari; Mohammad Reza Dayer; Nematollah Razmi; Mohammad Saaid Dayer

    2013-01-01

    PrPC conversion to PrPSc isoform is the main known cause for prion diseases including Crutzfeldt-Jakob, Gerstmann-Sträussler-Sheinker syndrome and fatal familial insomnia in human. The precise mechanism underling this conversion is yet to be well understood. In the present work, using the coordinate file of PrPC (available on the Protein Data Bank) as a starting structure, separate molecular dynamic simulations were carried out at neutral and acidic pH in an explicit water box at 37°C and 1 ...

  15. Branded prescription drug fee. Final regulations, temporary regulations, and removal of temporary regulations.

    Science.gov (United States)

    2014-07-28

    This document contains final regulations that provide guidance on the annual fee imposed on covered entities engaged in the business of manufacturing or importing branded prescription drugs. This fee was enacted by section 9008 of the Patient Protection and Affordable Care Act, as amended by section 1404 of the Health Care and Education Reconciliation Act of 2010. This document also withdraws the Branded Prescription Drug Fee temporary regulations and contains new temporary regulations regarding the definition of controlled group that apply beginning on January 1, 2015. The final regulations and the new temporary regulations affect persons engaged in the business of manufacturing or importing certain branded prescription drugs. The text of the temporary regulations in this document also serves as the text of proposed regulations set forth in a notice of proposed rulemaking (REG-123286-14) on this subject in the Proposed Rules section in this issue of the Federal Register.

  16. Interaction between Shadoo and PrP Affects the PrP-Folding Pathway.

    Science.gov (United States)

    Ciric, Danica; Richard, Charles-Adrien; Moudjou, Mohammed; Chapuis, Jérôme; Sibille, Pierre; Daude, Nathalie; Westaway, David; Adrover, Miguel; Béringue, Vincent; Martin, Davy; Rezaei, Human

    2015-06-01

    Prion diseases are characterized by conformational changes of a cellular prion protein (PrP(C)) into a β-sheet-enriched and aggregated conformer (PrP(Sc)). Shadoo (Sho), a member of the prion protein family, is expressed in the central nervous system (CNS) and is highly conserved among vertebrates. On the basis of histoanatomical colocalization and sequence similarities, it is suspected that Sho and PrP may be functionally related. The downregulation of Sho expression during prion pathology and the direct interaction between Sho and PrP, as revealed by two-hybrid analysis, suggest a relationship between Sho and prion replication. Using biochemical and biophysical approaches, we demonstrate that Sho forms a 1:1 complex with full-length PrP with a dissociation constant in the micromolar range, and this interaction consequently modifies the PrP-folding pathway. Using a truncated PrP that mimics the C-terminal C1 fragment, an allosteric binding behavior with a Hill number of 4 was observed, suggesting that at least a tetramerization state occurs. A cell-based prion titration assay performed with different concentrations of Sho revealed an increase in the PrP(Sc) conversion rate in the presence of Sho. Collectively, our observations suggest that Sho can affect the prion replication process by (i) acting as a holdase and (ii) interfering with the dominant-negative inhibitor effect of the C1 fragment. Since the inception of the prion theory, the search for a cofactor involved in the conversion process has been an active field of research. Although the PrP interactome presents a broad landscape, candidates corresponding to specific criteria for cofactors are currently missing. Here, we describe for the first time that Sho can affect PrP structural dynamics and therefore increase the prion conversion rate. A biochemical characterization of Sho-PrP indicates that Sho acts as an ATP-independent holdase. Copyright © 2015, American Society for Microbiology. All Rights

  17. Prévalence, facteurs associés et prédisposant au syndrome ...

    African Journals Online (AJOL)

    Introduction: Le syndrome métabolique est associé aux maladies cardiovasculaires. L'infection au VIH est devenue aujourd'hui une maladie chronique. L'objectif de cette étude est de déterminer la prévalence, les facteurs associés et prédisposant au syndrome métabolique chez les patients infectés par le VIH sous ...

  18. Der Effekt von Akupunktur in der Prävention von Prüfungsangst

    OpenAIRE

    Krüger, Peter

    2017-01-01

    Prüfungsangst ist ein weit verbreitetes gesellschaftliches Phänomen, das bisher in nur wenigen wissenschaftlichen Ansätzen untersucht wurde. Die Zahl der Studenten, die Gehirn - Doping zur Leistungssteigerung und zur Minimierung von Prüfungsangst nutzen, steigt stetig an. In bisherigen Studien wurde Akupunktur an Herz 7 als vielversprechende Behandlungsalternative dargestellt. Basierend auf diesen Ergebnissen, wurde in dieser Arbeit untersucht, ob eine Einzelpunktakupunktur an Herz 7 die ...

  19. Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice.

    Science.gov (United States)

    Fan, Jing; Stemkowski, Patrick L; Gandini, Maria A; Black, Stefanie A; Zhang, Zizhen; Souza, Ivana A; Chen, Lina; Zamponi, Gerald W

    2016-01-01

    Genetic ablation of cellular prion protein (PrP(C)) has been linked to increased neuronal excitability and synaptic activity in the hippocampus. We have previously shown that synaptic activity in hippocampi of PrP-null mice is increased due to enhanced N-methyl-D-aspartate receptor (NMDAR) function. Here, we focused on the effect of PRNP gene knock-out (KO) on intrinsic neuronal excitability, and in particular, the underlying ionic mechanism in hippocampal neurons cultured from P0 mouse pups. We found that the absence of PrP(C) profoundly affected the firing properties of cultured hippocampal neurons in the presence of synaptic blockers. The membrane impedance was greater in PrP-null neurons, and this difference was abolished by the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker ZD7288 (100 μM). HCN channel activity appeared to be functionally regulated by PrP(C). The amplitude of voltage sag, a characteristic of activating HCN channel current (I h), was decreased in null mice. Moreover, I h peak current was reduced, along with a hyperpolarizing shift in activation gating and slower kinetics. However, neither HCN1 nor HCN2 formed a biochemical complex with PrP(C). These results suggest that the absence of PrP downregulates the activity of HCN channels through activation of a cell signaling pathway rather than through direct interactions. This in turn contributes to an increase in membrane impedance to potentiate neuronal excitability.

  20. 41 CFR 101-27.504 - Notice to GSA.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Notice to GSA. 101-27.504 Section 101-27.504 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 27-INVENTORY MANAGEMENT 27.5-Return of GSA...

  1. 41 CFR 101-27.505 - Notice to activity.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Notice to activity. 101-27.505 Section 101-27.505 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 27-INVENTORY MANAGEMENT 27.5...

  2. 29 CFR 501.38 - Notice of docketing.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Notice of docketing. 501.38 Section 501.38 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF THE...

  3. 29 CFR 502.38 - Notice of docketing.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Notice of docketing. 502.38 Section 502.38 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ENFORCEMENT OF CONTRACTUAL OBLIGATIONS FOR TEMPORARY ALIEN AGRICULTURAL WORKERS ADMITTED UNDER SECTION 218 OF THE...

  4. Magnetic properties of Pr ions in perovskite-type oxides

    International Nuclear Information System (INIS)

    Sekizawa, K.; Kitagawa, M.; Takano, Y.

    1998-01-01

    Magnetic properties of Pr ions with the controlled valence on the A and B sites of perovskite-type oxides (ABO 3 ) were investigated for two systems. PrSc 1-x Mg x O 3 and BaPr 1-x Bi x O 3 . From the magnetic susceptibility χ versus temperature T curves of PrSc 1-x Mg x O 3 , the χ-T curve for molar Pr 3+ ions on the A site and that of Pr 4+ ions were obtained. The 1/χ-T curves for both ions exhibit the crystalline electric field (CEF) effect and the effective magneticmoment μ eff above 100 K is 3.41 μ B for Pr 3- and 2.58 μ B for Pr 4+ , respectively. The χ-T curve of PrSc 0.8 Mg 0.2 O 3 is similar to that of PrBa 2 Cu 3 O y . In the BaPr 1-x Bi x O 3 system, only one intermediate phase BaPr 0.5 Bi 0.5 O 3 exists, in which Pr and Bi take an ordered arrangement on the B site. The magnetic susceptibility χ for Pr 4+ and that of Pr 3+ in the ordered arrangement with Bi 5- on the B site are much smaller than those for the A site, reflecting the strong CEF effect on the B site. Experimental χ-T curves can be well reproducedby the numerical calculation for Pr 3+ or Pr 4+ ions in the molecular field and the CEF with proper respective parameters. (orig.)

  5. Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo.

    Science.gov (United States)

    Leidel, Fabienne; Eiden, Martin; Geissen, Markus; Hirschberger, Thomas; Tavan, Paul; Giese, Armin; Kretzschmar, Hans A; Schätzl, Hermann; Groschup, Martin H

    2014-02-28

    Prion diseases are fatal neurodegenerative disorders, which are not curable and no effective treatment exists so far. The major neuropathological change in diseased brains is the conversion of the normal cellular form of the prion protein PrPc(C) into a disease-associated isoform PrP(Sc). PrP(Sc) accumulates into multimeres and fibrillar aggregates, which leads to the formation of amyloid plaques. Increasing evidence indicates a fundamental role of PrP(Sc) species and its aggregation in the pathogenesis of prion diseases, which initiates the pathological cascade and leads to neurodegeneration accompanied by spongiform changes. In search of compounds that have the potential to interfere with PrP(Sc) formation and propagation, we used a cell based assay for the screening of potential aggregation inhibitors. The assay deals with a permanently prion infected cell line that was adapted for a high-throughput screening of a compound library composed of 10,000 compounds (DIVERset 2, ChemBridge). We could detect six different classes of highly potent inhibitors of PrP(Sc) propagation in vitro and identified piperazine derivatives as a new inhibitory lead structure, which increased incubation time of scrapie infected mice. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP

    OpenAIRE

    Sakudo, Akikazu; Onodera, Takashi

    2015-01-01

    Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp ?/?) mice. So far, six types of Prnp ?/? mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obtained from comparative studies of structural and functional analyses of these PrP family proteins do not ...

  7. 76 FR 51126 - Proposed Collection; Comment Request for Notice; Notice

    Science.gov (United States)

    2011-08-17

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Notice; Notice AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... in electing investment partnership (EIP). DATES: Written comments should be received on or before...

  8. Microstructure and martensitic transformation of Ni-Ti-Pr alloys

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Chunwang [Inner Mongolia University of Technology, College of Science, Hohhot (China); Shanghai Maritime University, College of Arts and Sciences, Shanghai (China); Zhao, Shilei; Jin, Yongjun; Hou, Qingyu [Inner Mongolia University of Technology, College of Science, Hohhot (China); Guo, Shaoqiang [Beihang University, Key Laboratory of Micro-nano Measurement, Manipulation and Physics (Ministry of Education), Department of Physics, Beijing (China)

    2017-09-15

    The effect of Pr addition on the microstructure and martensitic transformation behavior of Ni{sub 50}Ti{sub 50-x}Pr{sub x} (x = 0, 0.1, 0.3, 0.5, 0.7, 0.9) alloys were investigated experimentally. Results show that the microstructures of Ni-Ti-Pr alloys consist of the NiTi matrix and the NiPr precipitate with the Ti solute. The martensitic transformation start temperature decreases gradually with the increase in Pr fraction. The stress around NiPr precipitates is responsible for the decrease in martensitic transformation temperature with the increase in Pr fraction in Ni-Ti-Pr alloys. (orig.)

  9. Bi3+–Pr3+ energy transfer processes and luminescent properties of LuAG:Bi,Pr and YAG:Bi,Pr single crystalline films

    International Nuclear Information System (INIS)

    Zorenko, Y.; Gorbenko, V.; Savchyn, V.; Zorenko, T.; Nikl, M.; Mares, J.A.; Beitlerova, A.; Jary, V.

    2013-01-01

    Absorption, cathodoluminescence, excitation spectra of photoluminescence (PL) and PL decay kinetics were studied at 300 K for the double doped with Bi 3+ –Pr 3+ and separately doped with Bi 3+ and Pr 3+ Lu 3 Al 5 O 12 (LuAG) and Y 3 Al 5 O 12 (YAG) single crystalline film (SCF) phosphors grown by the liquid phase epitaxy method. The emission bands in the UV range arising from the intrinsic radiative transitions of Bi 3+ based centers, and emission bands in the visible range, related to the luminescence of excitons localized around Bi 3+ based centers, were identified both in Bi–Pr and Bi-doped LuAG and YAG SCFs. The energy transfer processes from the host lattice simultaneously to Bi 3+ and Pr 3+ ions and from Bi 3+ to Pr 3+ ions were investigated. Competition between Pr 3+ and Bi 3+ ions in the energy transfer processes from the LuAG and YAG hosts was evidenced. The strong decrease of the intensity of Pr 3+ luminescence both in LuAG:Pr and YAG:Pr SCFs phosphors, grown from Bi 2 O 3 flux, is observed due to the quenching influence of Bi 3+ flux related impurity. Due to overlap of the UV emission band of Bi 3+ centers with the f–d absorption bands of Pr 3+ ions in the UV range and the luminescence of excitons localized around Bi ions with the f–f absorption bands of Pr 3+ ions in the visible range, an effective energy transfer from Bi 3+ ions to Pr 3+ ions takes place in LuAG:Bi,Pr and YAG:Bi,Pr SCFs, resulting in the appearance of slower component in the decay kinetics of the Pr 3+ d–f luminescence. -- Highlights: • Bi and Pr doped film phosphor grown by liquid phase epitaxy method. • Energy transfer from Bi 3+ to Pr 3+ ions. • Strong quenching of the Pr 3+ luminescence by Bi 3+ co-dopant

  10. Præverbalitet i Musikterapi

    Directory of Open Access Journals (Sweden)

    Niels Hannibal

    2003-03-01

    Full Text Available Denne artikel er en oversættelse af mit foredrag på verdenskongressen i musikterapi i Oxford 2002. Den er baseret på min ph.d. afhandling »Præverbal Overføring i Musikterapi«, der blev forsvaret juni 2001. Formålet med artiklen er at validere min forskning om præverbal overføring i musikterapi i den musikalske interaktion gennem formidling af den pragmatiske anvendelse. I artiklen argumenterer jeg for anvendelse af Sterns psykologiske udviklingsteori og Sotolorow & Atwoodes teori om psykoterapi som fortolkningskontekst for musikalsk interaktion, når fokus er interaktion, relation og overføring. Det illustreres gennem en case analyse hvorledes begreberne kan anvendes på kliniske data. Det konkluderes at psykologisk teori og tænkning er nødvendig for at kunne forstå og beskrive musikalsk interaktion i et psykologisk perspektiv.

  11. Favoriser la prévention

    International Development Research Centre (IDRC) Digital Library (Canada)

    Les limites de ces axes d'in- tervention ... Le principal intérêt d'une stratégie nationale de prévention réside .... ricain pour le Développement Intégré (RADI,) le Comité de. Lutte contre ... logistiques et humains suffisants pour prendre en charge les cas. ... niveaux, participent à une dispersion des initiatives, des stratégies et ...

  12. Insight into Eu redox and Pr

    NARCIS (Netherlands)

    Zhou, Rongfu; Lin, Litian; Liu, Chunmeng; Dorenbos, P.; Tao, Ye; Huang, Yan; Liang, Hongbin

    2018-01-01

    A series of Ln-doped KSrPO4 (Ln = Ce3+, Eu3+, Eu2+, Pr3+) phosphors are prepared through a high-temperature solid-state method. The KSrPO4 compound is confirmed to possess a β-K2SO4 structure with the Pnma

  13. Advancing tendencies? PR leadership, general leadership, and leadership pedagogy

    OpenAIRE

    McKie, D; Willis, P

    2014-01-01

    What are the best ways to advance PR leadership? In exploring answers, we consider the last two decades of PR literature and identify two main tendencies. We link those two with general leadership literature and practices, as well as with literature on leadership pedagogy. We conclude that, rather than recent moves to look within the field, without self-reflection, to existing PR perspectives and figures for solutions, looking outwards has greater potential to transform not only the PR leader...

  14. 75 FR 50700 - Quarterly Listings; Safety Zones, Security Zones, Special Local Regulations, and Drawbridge...

    Science.gov (United States)

    2010-08-17

    ...] Quarterly Listings; Safety Zones, Security Zones, Special Local Regulations, and Drawbridge Operation... notice lists temporary safety zones, security zones, special local regulations, and drawbridge operation... responsive to the safety and security needs within their jurisdiction; therefore, District Commanders and...

  15. Genetic determinants of P wave duration and PR segment

    NARCIS (Netherlands)

    Verweij, Niek; Mateo Leach, Irene; van den Boogaard, Malou; van Veldhuisen, Dirk J.; Christoffels, Vincent M.; Hillege, Hans L.; van Gilst, Wiek H.; Barnett, Phil; de Boer, Rudolf A.; van der Harst, Pim

    2014-01-01

    The PR interval on the ECG reflects atrial depolarization and atrioventricular nodal delay which can be partially differentiated by P wave duration and PR segment, respectively. Genome-wide association studies have identified several genetic loci for PR interval, but it remains to be determined

  16. Genetic Determinants of P Wave Duration and PR Segment

    NARCIS (Netherlands)

    Verweij, Niek; Mateo Leach, Irene; van den Boogaard, Malou; van Veldhuisen, Dirk J.; Christoffels, Vincent M.; Hillege, Hans L.; van Gilst, Wiek H.; Barnett, Phil; de Boer, Rudolf A.; van der Harst, Pim

    Background-The PR interval on the ECG reflects atrial depolarization and atrioventricular nodal delay which can be partially differentiated by P wave duration and PR segment, respectively. Genome-wide association studies have identified several genetic loci for PR interval, but it remains to be

  17. On orbits and admissible subalgebras for the PR groups

    International Nuclear Information System (INIS)

    Lebedenko, V.M.

    1977-01-01

    The PR-groups (Lie groups with commutation relations of [Hsub(i),Hsub(0)] = rsub(ij)Hsub(i) (i< j)-type) are investigated within the Kirillov orbit method. Orbits for all the PR-groups are constructed in a general form. For some classes of PR-groups orbits and admissible subalgebras are obtained in an explicit form

  18. 78 FR 23975 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-04-23

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... definition of a controlled foreign corporation, foreign base company income and foreign personal holding...

  19. 76 FR 43381 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2011-07-20

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Financial Asset Securitization Investment Trusts; Real Estate Mortgage Investment Conduits (TD 9004 (final...

  20. 77 FR 62437 - Regulated Navigation Area; Columbus Day Weekend, Biscayne Bay, Miami, FL

    Science.gov (United States)

    2012-10-15

    ... Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking RNA Regulated Navigation Area I. Regulatory History and Information On July 25, 2012, we published a Notice of... Bay Columbus Day regulated navigation area (RNA), established in 2011 and contained in 33 CFR 165.779...

  1. Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis.

    Science.gov (United States)

    Sevillano, Alejandro M; Fernández-Borges, Natalia; Younas, Neelam; Wang, Fei; R Elezgarai, Saioa; Bravo, Susana; Vázquez-Fernández, Ester; Rosa, Isaac; Eraña, Hasier; Gil, David; Veiga, Sonia; Vidal, Enric; Erickson-Beltran, Melissa L; Guitián, Esteban; Silva, Christopher J; Nonno, Romolo; Ma, Jiyan; Castilla, Joaquín; R Requena, Jesús

    2018-01-01

    Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the β-strands and connecting loops that make up the PrPSc solenoid. Using high resolution SDS-PAGE followed by epitope analysis, and mass spectrometry, we identified positions ~116/118, 133-134, 141, 152-153, 162, 169 and 179 (murine numbering) as Proteinase K (PK) cleavage sites in PrPSc. Such sites likely define loops and/or borders of β-strands, helping us to predict the threading of the β-solenoid. We have now extended this approach to recombinant PrPSc (recPrPSc). The term recPrPSc refers to bona fide recombinant prions prepared by PMCA, exhibiting infectivity with attack rates of ~100%. Limited proteolysis of mouse and bank vole recPrPSc species yielded N-terminally truncated PK-resistant fragments similar to those seen in brain-derived PrPSc, albeit with varying relative yields. Along with these fragments, doubly N- and C-terminally truncated fragments, in particular ~89/97-152, were detected in some recPrPSc preparations; similar fragments are characteristic of atypical strains of brain-derived PrPSc. Our results suggest a shared architecture of recPrPSc and brain PrPSc prions. The observed differences, in particular the distinct yields of specific PK-resistant fragments, are likely due to differences in threading which result in the specific biochemical characteristics of recPrPSc. Furthermore, recombinant PrPSc offers exciting opportunities for structural studies unachievable with brain-derived PrPSc.

  2. 7 CFR 301.89-2 - Regulated articles.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Regulated articles. 301.89-2 Section 301.89-2... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Karnal Bunt § 301.89-2 Regulated articles. The following are regulated articles: (a) Conveyances, including trucks, railroad cars, and other...

  3. 78 FR 70100 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-11-22

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Nuclear Power Plant. OMB Number: 1545-1378. Regulation Project Number: TD 8580. Abstract: This regulation...

  4. 78 FR 76893 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-12-19

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments.... Regulation Project Number: REG-209626-93 (TD 8796). Abstract: These regulations provide guidance concerning...

  5. 78 FR 66251 - Electronic Fund Transfers(Regulation E)

    Science.gov (United States)

    2013-11-05

    ... Electronic Fund Transfers (Regulation E) AGENCY: Bureau of Consumer Financial Protection. ACTION: Notice of... subpart B of Regulation E, which implements the Electronic Fund Transfer Act, and published this list on...-rule-amendment-to-regulation-e/ . SUPPLEMENTARY INFORMATION: The Bureau published its remittance rule...

  6. Die prädikatsergänzung (das prädikatsattribut in der Slovenischen Syntax

    Directory of Open Access Journals (Sweden)

    Breda Pogorelec

    1972-12-01

    Full Text Available In der vorliegenden Abhandlung wird die erwähnte Problematik in der slovenischen grammatischen -Überlieferung behandelt und mit interessanten Ergebnissen vor allem der tschechischen Sprachtheorie ergänzt, es wird der Terminus Prädikatsergänzung gegenüber dem Terminus Prädikatsattribut begründet; auf dieser Grundlage werden auch die bisher behandelten Arten von Prädikatsergänzungen mit neuen ergänzt. Dabei findet wenn nur möglich das einfache Transformationsverfahren Verwendung, das die Veranschaulichung der stufenweisen Determinierung durch das Prädikatsattribut ermöglicht. Das Material entstammt vorwiegend der Sprache der Kunst, der Grund dafür ist vor allem in der Tatsache zu suchen, daß in dieser Sprache dieser Form die Rolle eines natürlichen Kondensators zufällt, weshalb sie verhältnismäßig häufig vorkommt. Die Abhandlung befaßt sich eingehender auch mit dem Problem der Wortfolge und berührt auch die graphische Darstellung der bei der Prädikatsergänzung üblichen Pausen.

  7. Regulating the Regulator

    Energy Technology Data Exchange (ETDEWEB)

    1992-08-26

    The article reports on a challenge to the UK electricity regulator to defend his record by the Coalition for Fair Electricity Regulation (COFFER). The challenge centres on whether the obligation for the regional electric companies (REC) to purchase power from the cheapest source is being enforced. This is related to the wider issue of whether the REC's support of combined-cycle gas turbine (CCGT) is economic. COFFER considers that uneconomic gas-fired power plants are being allowed to displace economic coal-fired stations. Aspects discussed include the background to the dispute and the costs of CCGT and coal fired power generation. 1 fig., 1 tab.

  8. Oscillatory exchange bias and training effects in nanocrystalline Pr0.5Ca0.5MnO3

    Directory of Open Access Journals (Sweden)

    S. Narayana Jammalamadaka

    2012-03-01

    Full Text Available We report on exchange bias effects in 10 nm particles of Pr0.5Ca0.5MnO3 which appear as a result of competing interactions between the ferromagnetic (FM/anti-ferromagnetic (AFM phases. The fascinating new observation is the demonstration of the temperature dependence of oscillatory exchange bias (OEB and is tunable as a function of cooling field strength below the SG phase, may be attributable to the presence of charge/spin density wave (CDW/SDW in the AFM core of PCMO10. The pronounced training effect is noticed at 5 K from the variation of the EB field as a function of number of field cycles (n upon the field cooling (FC process. For n > 1, power-law behavior describes the experimental data well; however, the breakdown of spin configuration model is noticed at n ≥ 1.

  9. Bolonia y la buena práctica de las prácticas

    OpenAIRE

    García Delgado, Javier

    2016-01-01

    A propósito de la implantación del controvertido “plan Bolonia” se están difundiendo algunas ideas negativas en relación con una supuesta “mercantilización” de la universidad, algunas relacionadas con la explotación de los estudiantes a través de las prácticas en empresas, o prácticas externas, sobre las cuales se reflexiona en este artículo. ¿Qué hemos aprendido tras las ya casi tres décadas transcurridas desde la promulgación del decreto del año 81 que autorizaba este tipo de prácticas? Ese...

  10. Magnetic and thermodynamic properties of the Pr-based ferromagnet PrGe2-δ

    Science.gov (United States)

    Matsumoto, Keisuke T.; Morioka, Naoya; Hiraoka, Koichi

    2018-03-01

    We investigated the magnetization, M, and specific heat, C, of ThSi2-type PrGe2-δ. A polycrystalline sample of PrGe2-δ was prepared by arc-melting. Magnetization divided by magnetic field, M / B, increased sharply and C showed a clear jump at the Curie temperature, TC, of 14.6 K; these results indicate that PrGe2-δ ordered ferromagnetically. The magnetic entropy at TC reached R ln 3, indicating a quasi-triplet crystalline electric field (CEF) ground state. The maximum value of magnetic entropy change was 11.5 J/K kg with a field change of 7 T, which is comparable to those of other right rare-earth based magnetocaloric materials. This large magnetic entropy change was attributed to the quasi-triplet ground state of the CEF.

  11. Growth and scintillation properties of Pr doped YAP with different Pr concentrations

    International Nuclear Information System (INIS)

    Yanagida, Takayuki; Kamada, Kei; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki; Yamaji, Akihiro; Yokota, Yuui; Yoshikawa, Akira

    2010-01-01

    Pr 3+ 0.2, 0.75, and 3 mol% doped YAP single crystalline scintillators were grown by using the micro-pulling down (μ-PD) method. Pr 3+ 0.05 mol% doped YAP was also prepared by using the Czochralski method. In transmittance spectra, 4f-5d absorption line appeared at 230 nm. The μ-PD grown crystals showed intense emission at 290 nm while the Czochralski grown one showed an emission peak at 245 nm in radio luminescence spectra under X-ray excitation. Among them, the Czochralski grown one exhibited the highest light yield under 137 Cs 662 keV excitation and the absolute light yield of this sample was estimated to be 20400±2000 ph/MeV. The decay time constants of these scintillators were around 10 ns due to Pr 3+ 5d-4f transition.

  12. Growth and scintillation properties of Pr doped YAP with different Pr concentrations

    Energy Technology Data Exchange (ETDEWEB)

    Yanagida, Takayuki, E-mail: t_yanagi@tagen.tohoku.ac.j [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Kamada, Kei; Fujimoto, Yutaka; Sugiyama, Makoto; Furuya, Yuki [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yamaji, Akihiro [New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan); Yokota, Yuui [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yoshikawa, Akira [Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); New Industry Creation Hatchery Center (NICHe), Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan)

    2010-11-21

    Pr{sup 3+} 0.2, 0.75, and 3 mol% doped YAP single crystalline scintillators were grown by using the micro-pulling down ({mu}-PD) method. Pr{sup 3+} 0.05 mol% doped YAP was also prepared by using the Czochralski method. In transmittance spectra, 4f-5d absorption line appeared at 230 nm. The {mu}-PD grown crystals showed intense emission at 290 nm while the Czochralski grown one showed an emission peak at 245 nm in radio luminescence spectra under X-ray excitation. Among them, the Czochralski grown one exhibited the highest light yield under {sup 137}Cs 662 keV excitation and the absolute light yield of this sample was estimated to be 20400{+-}2000 ph/MeV. The decay time constants of these scintillators were around 10 ns due to Pr{sup 3+} 5d-4f transition.

  13. Exotic behaviours in the Pr-based filled skutterudites

    International Nuclear Information System (INIS)

    Sato, H; Sugawara, H; Namiki, T; Saha, S R; Osaki, S; Matsuda, T D; Aoki, Y; Inada, Y; Shishido, H; Settai, R; Onuki, Y

    2003-01-01

    The exotic features of the Pr-based filled skutterudites are reviewed based on the electronic transport properties, specific heat and de Haas-van Alphen experiments, putting the emphasis on PrFe 4 P 12 and PrOs 4 Sb 12 . As references, the experiments on the related La- and Ce-filled skutterudites are also examined and discussed. Compared to their La reference compounds, the Fermi surface is very similar in PrOs 4 Sb 12 , suggesting the well localized character of 4f electrons, while it looks largely different in PrFe 4 P 12 . For the cyclotron effective mass, both PrFe 4 P 12 and PrOs 4 Sb 12 exhibit a strong enhancement, in reasonable agreement with the large specific heat coefficient

  14. Investigation of CaTiO3:Pr3+ thin films deposited by radiofrequency reactive magnetron sputtering for electroluminescence application

    International Nuclear Information System (INIS)

    Sarakha, L; Bousquet, A; Tomasella, E; Boutinaud, P; Mahiou, R

    2010-01-01

    In this report we successfully deposited thin films of CaTiO 3 :Pr 3+ by radiofrequency magnetron sputtering. The films were studied and we tried to understand the evolution of their optical and electrical properties. We noticed that the annealing temperature and the deposition pressures have an important influence on these properties. Thin films with good optical and electrical properties have been obtained. These films are transparent and are characterized by an intense red photoluminescence and a low fixed charge density. They are well dedicated for electroluminescence purposes.

  15. PrP expression, PrPSc accumulation and innervation of splenic compartments in sheep experimentally infected with scrapie.

    Directory of Open Access Journals (Sweden)

    Randi Sørby

    Full Text Available BACKGROUND: In prion disease, the peripheral expression of PrP(C is necessary for the transfer of infectivity to the central nervous system. The spleen is involved in neuroinvasion and neural dissemination in prion diseases but the nature of this involvement is not known. The present study undertook the investigation of the spatial relationship between sites of PrP(Sc accumulation, localisation of nerve fibres and PrP(C expression in the tissue compartments of the spleen of scrapie-inoculated and control sheep. METHODOLOGY/PRINCIPAL FINDINGS: Laser microdissection and quantitative PCR were used to determine PrP mRNA levels and results were compared with immunohistochemical protocols to distinguish PrP(C and PrP(Sc in tissue compartments of the spleen. In sheep experimentally infected with scrapie, the major sites of accumulation of PrP(Sc in the spleen, namely the lymphoid nodules and the marginal zone, expressed low levels of PrP mRNA. Double immunohistochemical labelling for PrP(Sc and the pan-nerve fibre marker, PGP, was used to evaluate the density of innervation of splenic tissue compartments and the intimacy of association between PrP(Sc and nerves. Some nerve fibres were observed to accompany blood vessels into the PrP(Sc-laden germinal centres. However, the close association between nerves and PrP(Sc was most apparent in the marginal zone. Other sites of close association were adjacent to the wall of the central artery of PALS and the outer rim of germinal centres. CONCLUSIONS/SIGNIFICANCE: The findings suggest that the degree of PrP(Sc accumulation does not depend on the expression level of PrP(C. Though several splenic compartments may contribute to neuroinvasion, the marginal zone may play a central role in being the compartment with most apparent association between nerves and PrP(Sc.

  16. 26 CFR 1.6036-1 - Notice of qualification as executor or receiver.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Notice of qualification as executor or receiver. 1.6036-1 Section 1.6036-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... executor or receiver. For provisions relating to the notice required of fiduciaries, see the regulations...

  17. 77 FR 67397 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey, Inc.

    Science.gov (United States)

    2012-11-09

    ...; Notice of Application; Johnson Matthey, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on September 10, 2012, Johnson Matthey, Inc., Pharmaceuticals Materials... Thebaine (9333) II The company plans to manufacture the listed controlled substances in bulk for...

  18. 78 FR 69132 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey, Inc.

    Science.gov (United States)

    2013-11-18

    ...; Notice of Application; Johnson Matthey, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on September 5, 2013, Johnson Matthey Inc., Custom Pharmaceuticals... Remifentanil (9739) II Sufentanil (9740) II Tapentadol (9780) II Fentanyl (9801) II The company plans to...

  19. 78 FR 69133 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey, Inc.

    Science.gov (United States)

    2013-11-18

    ...; Notice of Application; Johnson Matthey, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on September 5, 2013, Johnson Matthey, Inc., Pharmaceuticals Materials... Methadone (9250) II Methadone intermediate (9254) II Morphine (9300) II Thebaine (9333) II The company plans...

  20. 77 FR 30026 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey, Inc.

    Science.gov (United States)

    2012-05-21

    ...; Notice of Application; Johnson Matthey, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on March 26, 2012, Johnson Matthey, Inc., Custom Pharmaceuticals...), a basic class of controlled substance listed in schedule II. The company plans to manufacture the...

  1. 77 FR 67676 - Manufacturer of Controlled Substances; Notice of Application; Johnson Matthey Inc.

    Science.gov (United States)

    2012-11-13

    ...; Notice of Application; Johnson Matthey Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on September 10, 2012, Johnson Matthey Inc., Custom Pharmaceuticals... Remifentanil (9739) II Sufentanil (9740) II Fentanyl (9801) II The company plans to manufacture the listed...

  2. 7 CFR 319.55-5 - Notice of arrival by permittee.

    Science.gov (United States)

    2010-01-01

    ... arrival, the permittee or his agent shall submit a notice, in duplicate, to the Plant Protection and... 7 Agriculture 5 2010-01-01 2010-01-01 false Notice of arrival by permittee. 319.55-5 Section 319.55-5 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH...

  3. 21 CFR 1313.24 - Waiver of 15-day advance notice for chemical exporters.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Waiver of 15-day advance notice for chemical... IMPORTATION AND EXPORTATION OF LIST I AND LIST II CHEMICALS Exportation of Listed Chemicals § 1313.24 Waiver of 15-day advance notice for chemical exporters. (a) Each regulated person shall provide to the...

  4. 18 CFR 5.22 - Notice of acceptance and ready for environmental analysis.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Notice of acceptance and ready for environmental analysis. 5.22 Section 5.22 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS § 5.22 Notice o...

  5. Environmental assessments and findings of no significant impact--FDA. Notice.

    Science.gov (United States)

    1998-05-18

    The Food and Drug Administration (FDA) is announcing that it has reviewed environmental assessments (EA's) and issued findings of no significant impact (FONSI's) relating to the 167 new drug applications (NDA's) and supplemental applications listed in this document. FDA is publishing this notice because Federal regulations require public notice of the availability of environmental documents.

  6. 77 FR 67675 - Importer of Controlled Substances; Notice of Application; Watson Pharma, Inc.

    Science.gov (United States)

    2012-11-13

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; Watson Pharma, Inc. Pursuant to Title 21 Code of Federal Regulations 1301.34(a), this is notice that on August 28, 2012, Watson Pharma, Inc., 2455 Wardlow Road, Corona, California 92880-2882, made...

  7. 78 FR 33440 - Importer of Controlled Substances, Notice of Application; Watson Pharma, Inc.

    Science.gov (United States)

    2013-06-04

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances, Notice of Application; Watson Pharma, Inc. Pursuant to Title 21 Code of Federal Regulations 1301.34 (a), this is notice that on May 3, 2013, Watson Pharma, Inc., 2455 Wardlow Road, Corona, California 92880-2882, made...

  8. 78 FR 30332 - Manufacturer of Controlled Substances, Notice of Application, Austin Pharma, Llc.

    Science.gov (United States)

    2013-05-22

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances, Notice of Application, Austin Pharma, Llc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on March 28, 2013, Austin Pharma, LLC., 811 Paloma Drive, Suite C...

  9. 77 FR 30027 - Manufacturer of Controlled Substances; Notice of Application; Austin Pharma, LLC.

    Science.gov (United States)

    2012-05-21

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Austin Pharma, LLC. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on April 11, 2012, Austin Pharma, LLC., 811 Paloma Drive, Suite C...

  10. 77 FR 34073 - Manufacturer of Controlled Substances; Notice of Application; S&B Pharma, Inc.

    Science.gov (United States)

    2012-06-08

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; S&B Pharma, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on April 4, 2012, S&B Pharma Inc., 405 South Motor Avenue, Azusa...

  11. 78 FR 46613 - Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC

    Science.gov (United States)

    2013-08-01

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on June 10, 2013, Siegfried (USA), LLC., 33 Industrial Park Road...

  12. 78 FR 5500 - Manufacturer of Controlled Substances, Notice of Application; Siegfried (USA)

    Science.gov (United States)

    2013-01-25

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances, Notice of Application; Siegfried (USA) Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on June 19, 2012, Siegfried (USA), 33 Industrial Park Road, Pennsville...

  13. 77 FR 70825 - Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC

    Science.gov (United States)

    2012-11-27

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Siegfried (USA), LLC Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on November 5, 2012, Siegfried (USA) LLC, 33 Industrial Park Road...

  14. 78 FR 32458 - Manufacturer of Controlled Substances; Notice of Application; Siegfried USA, LLC

    Science.gov (United States)

    2013-05-30

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Siegfried USA, LLC Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on April 18, 2013, Siegfried USA, LLC., 33 Industrial Park Road...

  15. 77 FR 47108 - Manufacturer of Controlled Substances; Notice of Application; Cerilliant Corporation

    Science.gov (United States)

    2012-08-07

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Cerilliant Corporation Pursuant to Title 21 Code of Federal Regulations 1301.34 (a), this is notice that on July 6, 2012, Cerilliant Corporation, 811 Paloma Drive, Suite A, Round Rock...

  16. 78 FR 69130 - Importer of Controlled Substances; Notice of Application; Cerilliant Corporation

    Science.gov (United States)

    2013-11-18

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; Cerilliant Corporation Pursuant to Title 21 Code of Federal Regulations 1301.34(a), this is notice that on July 16, 2013, Cerilliant Corporation, 811 Paloma Drive, Suite A, Round Rock, Texas 78665...

  17. 77 FR 52366 - Manufacturer of Controlled Substances; Notice of Application; Cerilliant Corporation

    Science.gov (United States)

    2012-08-29

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Cerilliant Corporation Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on July 16, 2012, Cerilliant Corporation, 811 Paloma Drive...

  18. 78 FR 54917 - Manufacturer of Controlled Substances; Notice of Application; Cerilliant Corporation

    Science.gov (United States)

    2013-09-06

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Cerilliant Corporation Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on July 10, 2013, Cerilliant Corporation, 811 Paloma Drive...

  19. 78 FR 5499 - Manufacturer of Controlled Substances; Notice of Application; Cerilliant Corporation

    Science.gov (United States)

    2013-01-25

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Cerilliant Corporation Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on October 4, 2012, Cerilliant Corporation, 811 Paloma...

  20. 78 FR 57176 - Importer of Controlled Substances; Notice of Application: Cerilliant Corporation

    Science.gov (United States)

    2013-09-17

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application: Cerilliant Corporation Pursuant to Title 21 Code of Federal Regulations 1301.34(a), this is notice that on July 16, 2013, Cerilliant Corporation, 811 Paloma Drive, Suite A, Round Rock, Texas 78665...

  1. 77 FR 19717 - Manufacturer of Controlled Substances; Notice of Application; Cerilliant Corporation

    Science.gov (United States)

    2012-04-02

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Cerilliant Corporation Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on February 17, 2012, Cerilliant Corporation, 811 Paloma...

  2. 78 FR 39337 - Importer of Controlled Substances, Notice of Application, Boehringer Ingelheim Chemicals

    Science.gov (United States)

    2013-07-01

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances, Notice of Application, Boehringer Ingelheim Chemicals Pursuant to Title 21 Code of Federal Regulations 1301.34(a), this is notice that on May 31, 2013, Boehringer Ingelheim Chemicals, 2820 N. Normandy Drive, Petersburg...

  3. 77 FR 43863 - Manufacturer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals Inc.

    Science.gov (United States)

    2012-07-26

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on June 8, 2012, Boehringer Ingelheim Chemicals...

  4. 77 FR 43861 - Importer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals

    Science.gov (United States)

    2012-07-26

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals Pursuant to Title 21 Code of Federal Regulations 1301.34(a), this is notice that on June 8, 2012, Boehringer Ingelheim Chemicals, Inc., 2820 N. Normandy Drive...

  5. 78 FR 39340 - Manufacturer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals, Inc.

    Science.gov (United States)

    2013-07-01

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Boehringer Ingelheim Chemicals, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on May 31, 2013, Boehringer Ingelheim Chemicals...

  6. 77 FR 67396 - Importer of Controlled Substances; Notice of Application, Fisher Clinical Services, Inc.

    Science.gov (United States)

    2012-11-09

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application, Fisher Clinical Services, Inc. Pursuant to Title 21 Code of Federal Regulations 1301.34(a), this is notice that on August 20, 2012, Fisher Clinical Services, Inc., 7554 Schantz Road, [[Page 67397...

  7. 77 FR 60143 - Importer of Controlled Substances; Notice of Application; Fisher Clinical Services, Inc.

    Science.gov (United States)

    2012-10-02

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; Fisher Clinical Services, Inc. Pursuant to Title 21 Code of Federal Regulations 1301.34(a), this is notice that on July 18, 2012, Fisher Clinical Services, Inc., 7554 Schantz Road, Allentown...

  8. 77 FR 72409 - Importer of Controlled Substances; Notice of Application; Fisher Clinical Services, Inc.

    Science.gov (United States)

    2012-12-05

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; Fisher Clinical Services, Inc. Pursuant to Title 21 Code of Federal Regulations 1301.34 (a), this is notice that on October 16, 2012, Fisher Clinical Services, Inc., 7554 Schantz Road, Allentown...

  9. 78 FR 59064 - Importer of Controlled Substances; Notice of Application; Fisher Clinical Services, Inc.

    Science.gov (United States)

    2013-09-25

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; Fisher Clinical Services, Inc. Pursuant to Title 21 Code of Federal Regulations (CFR) 1301.34 (a), this is notice that on June 21, 2013, Fisher Clinical Services, Inc., 7554 Schantz Road, Allentown...

  10. 78 FR 23594 - Importer of Controlled Substances, Notice of Application, Almac Clinical Services, Inc., (ACSI)

    Science.gov (United States)

    2013-04-19

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances, Notice of Application, Almac Clinical Services, Inc., (ACSI) Pursuant to Title 21 Code of Federal Regulations 1301.34(a), this is notice that on March 5, 2013, Almac Clinical Services, Inc., (ACSI), 25 Fretz Road, Souderton...

  11. 75 FR 53295 - Hatchet Ridge Wind, LLC; Notice of Effectiveness of Exempt Wholesale Generator Status

    Science.gov (United States)

    2010-08-31

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EG10-39-000] Hatchet Ridge Wind, LLC; Notice of Effectiveness of Exempt Wholesale Generator Status August 23, 2010. Take notice... Generator became effective by operation of the Commission's regulations, 18 CFR 366.7(a). Nathaniel J. Davis...

  12. 76 FR 36533 - Bangor Hydro Electric Company; Notice of Request for Waiver

    Science.gov (United States)

    2011-06-22

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. TS11-5-000] Bangor Hydro Electric Company; Notice of Request for Waiver Take notice that on June 13, 2011, pursuant to section 358.1(d) of the Commission's regulations, 18 CFR 358.1(d) (2011), Bangor Hydro Electric Company (Bangor...

  13. 76 FR 18216 - Southern Natural Gas Company; Notice of Request Under Blanket Authorization

    Science.gov (United States)

    2011-04-01

    ... Natural Gas Company; Notice of Request Under Blanket Authorization Take notice that on March 16, 2011, Southern Natural Gas Company (Southern), Post Office Box 2563, Birmingham, Alabama 35202-2563, filed in... Regulations under the Natural Gas Act (NGA) as amended, to abandon in place a supply lateral that extends from...

  14. 75 FR 13535 - Northern Natural Gas Company; Notice of Request Under Blanket Authorization

    Science.gov (United States)

    2010-03-22

    ... Natural Gas Company; Notice of Request Under Blanket Authorization March 16, 2010. Take notice that on March 12, 2010, Northern Natural Gas Company (Northern), 1111 South 103rd Street, Omaha, Nebraska 68124... Federal Energy Regulatory Commission's regulations under the Natural Gas Act for authorization to abandon...

  15. 77 FR 31004 - Southern Natural Gas Company; Notice of Request Under Blanket Authorization

    Science.gov (United States)

    2012-05-24

    ... Natural Gas Company; Notice of Request Under Blanket Authorization Take notice that on May 9, 2012, Southern Natural Gas Company (Southern), 569 Brookwood Village, Suite 501, Birmingham, Alabama 35209, filed... Commission's regulations under the Natural Gas Act (NGA), and Southern's blanket certificate issued in Docket...

  16. 75 FR 3232 - Northern Natural Gas Company; Notice of Request Under Blanket Authorization

    Science.gov (United States)

    2010-01-20

    ... Natural Gas Company; Notice of Request Under Blanket Authorization January 8, 2010. Take notice that on December 30, 2009, Northern Natural Gas Company (Northern), 1111 South 103rd Street, Omaha, Nebraska 68124...'s regulations under the Natural Gas Act for authorization to increase its maximum storage capacity...

  17. 48 CFR 52.230-1 - Cost Accounting Standards Notices and Certification.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Cost Accounting Standards... Provisions and Clauses 52.230-1 Cost Accounting Standards Notices and Certification. As prescribed in 30.201-3, insert the following provisions: Cost Accounting Standards Notices and Certification (OCT 2008...

  18. 78 FR 15974 - Importer of Controlled Substances, Notice of Application; Meridian Medical Technologies

    Science.gov (United States)

    2013-03-13

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances, Notice of Application; Meridian Medical Technologies Pursuant to Title 21 Code of Federal Regulations 1301.34 (a), this is notice that on January 8, 2013, Meridian Medical Technologies, 2555 Hermelin Drive, St. Louis...

  19. 78 FR 14350 - Notice of Single Family Loan Sales (SFLS 2013-1)

    Science.gov (United States)

    2013-03-05

    ...-708- 2625, extension 3927. Hearing- or speech-impaired individuals may call 202-708-4594 (TTY). These... backing Ginnie Mae mortgage-backed securities extinguished and terminated by Ginnie Mae. Freedom of... Freedom of Information Act and all regulations promulgated thereunder. Scope of Notice This notice applies...

  20. 76 FR 47226 - Notice of HUD-Held Multifamily Loan Sale (MLS 2011-2)

    Science.gov (United States)

    2011-08-04

    ...., Washington, DC 20410-8000; telephone number 202- 708-2625, extension 3927. Hearing- or speech-impaired... with HUD, unless such default or violation is cured on or before June 30, 2011; Freedom of Information... Freedom of Information Act and all regulations promulgated thereunder. Scope of Notice This notice applied...

  1. 75 FR 12775 - Notice of HUD-Held Multifamily and Healthcare Loan Sale

    Science.gov (United States)

    2010-03-17

    ... 20410-8000; telephone number 202-708-2625, extension 3927. Hearing- or speech-impaired individuals may... determine whether they are eligible to submit bids on the Mortgage Loans in MHLS 2010-1. Freedom of... the Freedom of Information Act and all regulations promulgated thereunder. Scope of Notice This notice...

  2. 29 CFR 4281.43 - Notices of insolvency and annual updates.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Notices of insolvency and annual updates. 4281.43 Section 4281.43 Labor Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION INSOLVENCY... MASS WITHDRAWAL Benefit Suspensions § 4281.43 Notices of insolvency and annual updates. (a) Requirement...

  3. 76 FR 46805 - Notice of Utah Adoption by Reference of the Pesticide Container Containment Rule

    Science.gov (United States)

    2011-08-03

    ... ENVIRONMENTAL PROTECTION AGENCY [FRL-9447-8] Notice of Utah Adoption by Reference of the Pesticide Container Containment Rule AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: This... Pesticide Container Containment (PCC) Rule regulations. In accordance with State of Utah Agricultural Code...

  4. 15 CFR 990.44 - Notice of Intent to Conduct Restoration Planning.

    Science.gov (United States)

    2010-01-01

    ... Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OIL POLLUTION ACT REGULATIONS NATURAL RESOURCE DAMAGE ASSESSMENTS Preassessment Phase § 990.44 Notice of Intent... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Notice of Intent to Conduct...

  5. 78 FR 64018 - Manufacturer of Controlled Substances; Notice of Application; GE Healthcare

    Science.gov (United States)

    2013-10-25

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; GE Healthcare Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on September 12, 2013, GE Healthcare, 3350 North Ridge Avenue...

  6. 78 FR 8583 - Importer of Controlled Substances; Notice of Application; GE Healthcare

    Science.gov (United States)

    2013-02-06

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; GE Healthcare Pursuant to Title 21 Code of Federal Regulations 1301.34 (a), this is notice that on July 28, 2011, GE Healthcare, 3350 North Ridge Avenue, Arlington Heights, Illinois 60004-1412...

  7. 78 FR 36594 - Importer of Controlled Substances; Notice of Application GE Healthcare

    Science.gov (United States)

    2013-06-18

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application GE Healthcare Pursuant to Title 21, Code of Federal Regulations 1301.34(a), this is notice that on April 29, 2013, GE Healthcare, 3350 North Ridge Avenue, Arlington Heights, Illinois 60004-1412, made...

  8. 78 FR 12103 - Manufacturer of Controlled Substances; Notice of Application; GE Healthcare

    Science.gov (United States)

    2013-02-21

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; GE Healthcare Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on August 31, 2012, GE Healthcare, 3350 North Ridge Avenue, Arlington...

  9. 78 FR 69447 - Importer of Controlled Substances; Notice of Application; GE Healthcare

    Science.gov (United States)

    2013-11-19

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; GE Healthcare Pursuant to Title 21, Code of Federal Regulations 1301.34(a), this is notice that on September 18, 2013, GE Healthcare, 3350 North Ridge Avenue, Arlington Heights, Illinois 60004-1412...

  10. 78 FR 51210 - Manufacturer of Controlled Substances; Notice of Application; Halo Pharmaceutical, Inc.

    Science.gov (United States)

    2013-08-20

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Halo Pharmaceutical, Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on July 8, 2013, Halo Pharmaceutical, Inc., 30 North...

  11. 78 FR 12101 - Importer of Controlled Substances; Notice of Application; Caraco Pharmaceutical Laboratories, LTD.

    Science.gov (United States)

    2013-02-21

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Importer of Controlled Substances; Notice of Application; Caraco Pharmaceutical Laboratories, LTD. Pursuant to Title 21 Code of Federal Regulations 1301.34 (a), this is notice that on November 22, 2012, Caraco Pharmaceutical Laboratories, Ltd., 270 Prospect...

  12. 77 FR 47114 - Manufacturer of Controlled Substances; Notice of Application; Halo Pharmaceutical Inc.

    Science.gov (United States)

    2012-08-07

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration Manufacturer of Controlled Substances; Notice of Application; Halo Pharmaceutical Inc. Pursuant to Sec. 1301.33(a), Title 21 of the Code of Federal Regulations (CFR), this is notice that on July 6, 2012, Halo Pharmaceutical Inc., 30 North...

  13. 77 FR 58818 - Notice of Proposed Information Collection Requests; Federal Student Aid; William D. Ford Federal...

    Science.gov (United States)

    2012-09-24

    ... DEPARTMENT OF EDUCATION Notice of Proposed Information Collection Requests; Federal Student Aid; William D. Ford Federal Direct Loan Program Regulations-- Servicemembers Civil Relief Act SUMMARY: Upon a... in response to this notice will be considered public records. Title of Collection: William D. Ford...

  14. Radio- and VUV - Excited Luminescence of YAP:Ce, YAP:Pr and YAG:Pr

    Science.gov (United States)

    2001-01-01

    Pr 3+ ions.", Acta Physica Polonica A, 90 pp.407-10, 1996. 6. C. Pedrini, D. Bouttet, C. Dujardin, B. Moine, I. Dafinei, P. Lecoq, M. Koselja, K...34Spectroscopy and thermoluminescence of LuAIO 3:Ce" Acta Physica Polonica A,.90, pp.377-383, 1996 17. A.J. Wojtowicz, J. Glodo, W. Drozdowski, K.R. Przegietka...Malinowski, M.F. Joubert, B. Jacquier. "Simultaneous laser action at blue and orange wavelengths in YAG:Pr 3+ Physica Status Solidi A, 140, pp.K49-52, 1993 5

  15. Présentation des auteurs

    OpenAIRE

    2016-01-01

    Jean-Pierre Cléro, université de Haute-Normandie, Rouen Andrea Emiliani, président de l’academia Clementina de Bologna (Italie) Pascal Griener, université de Neuchâtel (Suisse) Yves Hersant, École des hautes études en sciences sociales, Paris Philippe Junod, université de Lausane (Suisse) Françoise Knopper, université de Toulouse 2-Le Mirail Centre de Recherches et d’Études germaniques (CREG) Didier Laroque, École supérieure d’architecture, Paris Val de Seine Alain Michel, de l’Institut Jacki...

  16. PR-10 proteins as potential mediators of melatonin-cytokinin cross-talk in plants: crystallographic studies of LlPR-10.2B isoform from yellow lupine.

    Science.gov (United States)

    Sliwiak, Joanna; Sikorski, Michal; Jaskolski, Mariusz

    2018-04-06

    LlPR-10.2B, a Pathogenesis-related class 10 (PR-10) protein from yellow lupine (Lupinus luteus) was crystallized in complex with melatonin, an emerging important plant regulator and antioxidant. The structure reveals two molecules of melatonin bound in the internal cavity of the protein, plus a very well-defined electron density near the cavity entrance, corresponding to an unknown ligand molecule comprised of two flat rings, which is most likely a product of melatonin transformation. In a separate LlPR-10.2B co-crystallization experiment with an equimolar mixture of melatonin and trans-zeatin, which is a cytokinin phytohormone well recognized as a PR-10-binding partner, a quaternary 1 : 1 : 1 : 1 complex was formed, in which one of the melatonin-binding sites has been substituted with trans-zeatin, whereas the binding of melatonin at the second binding site and binding of the unknown ligand are undisturbed. This unusual complex, when compared with the previously described PR-10/trans-zeatin complexes and with the emerging structural information about melatonin binding by PR-10 proteins, provides intriguing insights into the role of PR-10 proteins in phytohormone regulation in plants, especially with the involvement of melatonin, and implicates the PR-10 proteins as low-affinity melatonin binders under the conditions of elevated melatonin concentration. Atomic coordinates and processed structure factors corresponding to the final models of the LlPR-10.2B/melatonin and LlPR-10.2B/melatonin + trans-zeatin complexes have been deposited with the Protein Data Bank (PDB) under the accession codes 5MXB and 5MXW. The corresponding raw X-ray diffraction images have been deposited in the RepOD Repository at the Interdisciplinary Centre for Mathematical and Computational Modelling (ICM) of the University of Warsaw, Poland, and are available for download with the following Digital Object Identifiers (DOI): https://doi.org/10.18150/repod.9923638 and https://doi.org/10

  17. Thermal reorientation of hydrogenic Pr3+ centers

    International Nuclear Information System (INIS)

    Jones, G. D.

    1996-01-01

    Sets of five multi-hydrogenic centers of both CaF 2 :Pr 3+ and SrF 2 :Pr 3 + show bleaching under selective polarized-light irradiation. Two forms of bleaching behaviour are observed. In reversible polarized bleaching, irradiation creates re-oriented equivalent centers, which can be restored to the original orientation by switching the laser polarization by 90 deg. Indefinite sequences of bleaching and recovery can be established. In photoproduct bleaching, inequivalent centers are produced, which can be reverted by subsequently selectively exciting their absorption lines. Thermal recovery of the bleached centers on warming the crystals occurs abruptly over a 5 K range around 100 K and is noteworthy in occurring at essentially identical temperatures for H - , D - and T - centers. The simplest model for this thermal recovery is thermal activation of the mobile hydrogenic ions over a double well potential barrier. An alternative model proposed by Universitaet Regensburg requires the involvement of high frequency excitations in scattering processes for surmounting the barrier

  18. Functional genomics identifies regulators of the phototransduction machinery in the Drosophila larval eye and adult ocelli.

    Science.gov (United States)

    Mishra, Abhishek Kumar; Bargmann, Bastiaan O R; Tsachaki, Maria; Fritsch, Cornelia; Sprecher, Simon G

    2016-02-15

    Sensory perception of light is mediated by specialized Photoreceptor neurons (PRs) in the eye. During development all PRs are genetically determined to express a specific Rhodopsin (Rh) gene and genes mediating a functional phototransduction pathway. While the genetic and molecular mechanisms of PR development is well described in the adult compound eye, it remains unclear how the expression of Rhodopsins and the phototransduction cascade is regulated in other visual organs in Drosophila, such as the larval eye and adult ocelli. Using transcriptome analysis of larval PR-subtypes and ocellar PRs we identify and study new regulators required during PR differentiation or necessary for the expression of specific signaling molecules of the functional phototransduction pathway. We found that the transcription factor Krüppel (Kr) is enriched in the larval eye and controls PR differentiation by promoting Rh5 and Rh6 expression. We also identified Camta, Lola, Dve and Hazy as key genes acting during ocellar PR differentiation. Further we show that these transcriptional regulators control gene expression of the phototransduction cascade in both larval eye and adult ocelli. Our results show that PR cell type-specific transcriptome profiling is a powerful tool to identify key transcriptional regulators involved during several aspects of PR development and differentiation. Our findings greatly contribute to the understanding of how combinatorial action of key transcriptional regulators control PR development and the regulation of a functional phototransduction pathway in both larval eye and adult ocelli. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Determination of the differences in oxidation potentials for the Pr3+/Pr2+ and Ce3+/Ce2+ pairs in halide melts

    International Nuclear Information System (INIS)

    Mikheev, N.B.; Auerman, L.N.; Rumer, I.A.; D'yachkova, R.A.

    1983-01-01

    Cocrystallization has been used with the (PrOCl)/sub s. ph/ - (PrCl 2 , PrCl 3 , SrCl 2 ) melt system to examine the dependence of the cerium(III) cocrystallization coefficient on the X/sub Pr 2+ /X/sub Pr 3+ / ratio in the melt. Measurement has been made in this way of the difference in oxidation potentials for the pairs Pr 3+ /Pr 2+ and Ce 3+ /Ce 2+ : ΔE/sub Pr 3+ /Pr 2+0 -E/sub Ce 3+ /Ce 2+ / 0 , which is 0.08 +/- 0.04 V for chloride

  20. Market, Regulation, Market, Regulation

    DEFF Research Database (Denmark)

    Frankel, Christian; Galland, Jean-Pierre

    2015-01-01

    barriers to trade in Europe, realized the free movement of products by organizing progressively several orders of markets and regulation. Based on historical and institutional documents, on technical publications, and on interviews, this article relates how the European Commission and the Member States had......This paper focuses on the European Regulatory system which was settled both for opening the Single Market for products and ensuring the consumers' safety. It claims that the New Approach and Standardization, and the Global Approach to conformity assessment, which suppressed the last technical...... alternatively recourse to markets and to regulations, at the three main levels of the New Approach Directives implementation. The article focuses also more specifically on the Medical Devices sector, not only because this New Approach sector has long been controversial in Europe, and has recently been concerned...

  1. The PR in PN for Education Associations. PR Bookshelf, No. 3.

    Science.gov (United States)

    National Education Association, Washington, DC.

    This booklet presents suggestions and guidelines for the effective use of public relations (PR) techniques during professional negotiations (PN) among teachers, administrators, and boards of education. Introductory sections present the National Education Association (NEA) position regarding professional negotiation and grievance procedures and…

  2. 75 FR 56093 - Eagle Rock Desoto Pipeline, LP; Notice of Motion for Extension of Rate Case Filing Deadline

    Science.gov (United States)

    2010-09-15

    ... pipelines to extend the cycle for such reviews from three to five years.\\1\\ Therefore, Eagle Rock requests... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR09-1-002] Eagle Rock... notice that on September 8, 2010, Eagle Rock Desoto Pipeline, L.P. (Eagle Rock) filed a request to extend...

  3. 77 FR 67029 - Arden Investment Series Trust and Arden Asset Management LLC; Notice of Application

    Science.gov (United States)

    2012-11-08

    ... Investment Series Trust and Arden Asset Management LLC; Notice of Application November 2, 2012. AGENCY... disclosure requirements. Applicants: Arden Investment Series Trust (the ``Trust'') and Arden Asset Management... Company Regulation, Division of Investment Management). SUPPLEMENTARY INFORMATION: The following is a...

  4. 75 FR 47318 - GE Asset Management Incorporated and GE Investment Distributors, Inc.; Notice of Application and...

    Science.gov (United States)

    2010-08-05

    ...] GE Asset Management Incorporated and GE Investment Distributors, Inc.; Notice of Application and.... Applicants: GE Asset Management Incorporated (``GEAM'') and GE Investment Distributors, Inc. (``GEID... of Investment Management, Office of Investment Company Regulation). SUPPLEMENTARY INFORMATION: The...

  5. 77 FR 67407 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978

    Science.gov (United States)

    2012-11-09

    ... designation of certain animals and certain geographic areas a requiring special protection. The regulations establish such a permit system to designate Antarctic Specially Protected Areas. The applications received... NATIONAL SCIENCE FOUNDATION Notice of Permit Applications Received Under the Antarctic...

  6. Association of body mass index with ER, PR and 14-3-3σ expression in tumor and stroma of type I and type II endometrial carcinoma.

    Science.gov (United States)

    Peevey, Joseph F; Seagle, Brandon-Luke L; Maniar, Kruti P; Kim, J Julie

    2017-06-27

    Obesity is a prominent risk factor for endometrial cancer (EC) and can impede on surgical and hormonal treatments. Markers of EC, estrogen receptor (ER), progesterone receptor (PR), phospho(Ser473)-AKT (pAKT) and 14-3-3 sigma (14-3-3σ) were measured in EC tissues in both the tumor and stroma and grouped by body mass index (BMI). Immunohistochemical scoring of 82 cases of Type 1 and Type II EC tissues revealed a significantly increased tumor expression of ER, PR and 14-3-3σ in women with Type I (BMI PR and 14-3-3σ in the tumor epithelium was significantly higher in Type I than Type II. In particular, Type I EC exhibited significantly increased levels of only PR from patients with BMI > 40 compared to BMI PR, PIK3CA, PTEN and SFN (gene for 14-3-3σ) confirmed increased PR expression in EC of obese women. In conclusion, ER, PR and 14-3-3σ are differentially regulated in Type I compared to Type II EC while PR is dysregulated in obese women with Type I EC. These findings have potential implications for efficacy of progestin treatment in obese women.

  7. Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP

    Science.gov (United States)

    Sakudo, Akikazu; Onodera, Takashi

    2015-01-01

    Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp−/−) mice. So far, six types of Prnp−/− mice have been generated, demonstrating the promiscuous functions of PrP. Recently, other PrP family members, such as Doppel and Shadoo, have been found. However, information obtained from comparative studies of structural and functional analyses of these PrP family proteins do not fully reveal PrP functions. Recently, varieties of Prnp−/− cell lines established from Prnp−/− mice have contributed to the analysis of PrP functions. In this mini-review, we focus on Prnp−/− cell lines and summarize currently available Prnp−/− cell lines and their characterizations. In addition, we introduce the recent advances in the methodology of cell line generation with knockout or knockdown of the PrP gene. We also discuss how these cell lines have provided valuable insights into PrP functions and show future perspectives. PMID:25642423

  8. Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice.

    Science.gov (United States)

    Salaga, M; Polepally, P R; Zielinska, M; Marynowski, M; Fabisiak, A; Murawska, N; Sobczak, K; Sacharczuk, M; Do Rego, J C; Roth, B L; Zjawiony, J K; Fichna, J

    2015-09-01

    The opioid system plays a crucial role in several physiological processes in the CNS and in the periphery. It has also been shown that selective opioid receptor agonists exert potent inhibitory action on pruritus and pain. In this study we examined whether two analogues of Salvinorin A, PR-37 and PR-38, exhibit antipruritic properties in mice. To examine the antiscratch effect of PR-37 and PR-38 we used a mouse model of compound 48/80-induced pruritus. In order to elucidate the mechanism of action of tested compounds, specific antagonists of opioid and cannabinoid receptors were used. The effect of PR-37 on the CNS was assessed by measuring motor parameters and exploratory behaviours in mice. PR-37 and PR-38, jnjected s.c., significantly reduced the number of compound 48/80-induced scratching behaviours in mice in a dose- and time-dependent manner. PR-38 was also active when orally administered. The antiscratch activity of PR-37 was blocked by the selective κ opioid receptor antagonist, nor-binaltorphimine, and that of PR-38 by the selective μ opioid receptor antagonist, β-funaltrexamine. In conclusion, a novel framework for the development of new antipruritic drugs derived from salvinorin A has been validated. © 2015 The British Pharmacological Society.

  9. Experimental Models of Inherited PrP Prion Diseases.

    Science.gov (United States)

    Watts, Joel C; Prusiner, Stanley B

    2017-11-01

    The inherited prion protein (PrP) prion disorders, which include familial Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia, constitute ∼10%-15% of all PrP prion disease cases in humans. Attempts to generate animal models of these disorders using transgenic mice expressing mutant PrP have produced variable results. Although many lines of mice develop spontaneous signs of neurological illness with accompanying prion disease-specific neuropathological changes, others do not. Furthermore, demonstrating the presence of protease-resistant PrP species and prion infectivity-two of the hallmarks of the PrP prion disorders-in the brains of spontaneously sick mice has proven particularly challenging. Here, we review the progress that has been made toward developing accurate mouse models of the inherited PrP prion disorders. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

  10. Study of PrP - I heterogeneous equilibrium

    International Nuclear Information System (INIS)

    Vasil'eva, I.G.; Mironov, K.E.; Tarasenko, A.D.

    1976-01-01

    Using static methods the authors have measured the equilibrium vapor pressure in the system PrP+I 2 at different temperatures and different initial iodine concentrations. The equilibrium reactions in the system have been determined. The reaction of PrP with iodine is irreversible. The content of PrI 3 and I 2 in the gas phase is negligible. The pressure in the system is determined by the partial pressure of phosphorus

  11. Features of the advertising and PR in tourism

    OpenAIRE

    M. A. Zubarieva

    2015-01-01

    The article discusses the use of topical issues of important tools of social communication of applied tactical direction (advertising) and strategic (PR). The main types of advertising in tourism and types of PR ­ activities are characterized.The main difference between advertising and PR in the tourism sector is defined, the main attention is given to correct choice of optimal (most efficient) advertising channel (means). Specific nature, advertising issues as the main tool for the promotion...

  12. Prion propagation in cells expressing PrP glycosylation mutants.

    Science.gov (United States)

    Salamat, Muhammad K; Dron, Michel; Chapuis, Jérôme; Langevin, Christelle; Laude, Hubert

    2011-04-01

    Infection by prions involves conversion of a host-encoded cell surface protein (PrP(C)) to a disease-related isoform (PrP(Sc)). PrP(C) carries two glycosylation sites variably occupied by complex N-glycans, which have been suggested by previous studies to influence the susceptibility to these diseases and to determine characteristics of prion strains. We used the Rov cell system, which is susceptible to sheep prions, to generate a series of PrP(C) glycosylation mutants with mutations at one or both attachment sites. We examined their subcellular trafficking and ability to convert into PrP(Sc) and to sustain stable prion propagation in the absence of wild-type PrP. The susceptibility to infection of mutants monoglycosylated at either site differed dramatically depending on the amino acid substitution. Aglycosylated double mutants showed overaccumulation in the Golgi compartment and failed to be infected. Introduction of an ectopic glycosylation site near the N terminus fully restored cell surface expression of PrP but not convertibility into PrP(Sc), while PrP(C) with three glycosylation sites conferred cell permissiveness to infection similarly to the wild type. In contrast, predominantly aglycosylated molecules with nonmutated N-glycosylation sequons, produced in cells expressing glycosylphosphatidylinositol-anchorless PrP(C), were able to form infectious PrP(Sc). Together our findings suggest that glycosylation is important for efficient trafficking of anchored PrP to the cell surface and sustained prion propagation. However, properly trafficked glycosylation mutants were not necessarily prone to conversion, thus making it difficult in such studies to discern whether the amino acid changes or glycan chain removal most influences the permissiveness to prion infection.

  13. Nuclear regulation in transition

    International Nuclear Information System (INIS)

    Tomain, J.P.

    1986-01-01

    The current state of nuclear regulations in the USA is examined. Since Three Mile Island the regulation of the nuclear power industry has been undergoing a noticeable transition. It will be argued here that the transition is characterized by two indicia. First, the primary focus of state and federal regulators has been on the financial aspects of the industry: this is best seen in the context of decisions allocating the costs of nuclear plant cancellations. Second, decisionmaking power has been decentralized: although the regulatory history of nuclear power demonstrates the tradition of centralized decisionmaking power (i.e., formerly the primary decisionmaking body was the Atomic Energy Commission), now States share decisionmaking power with the Nuclear Regulatory Commission. In Section 1 a brief legislative history of nuclear regulation is presented to establish the assertion that nuclear regulation, both de jure and de facto, was centralized. Next, Section 2 canvasses recent United States Supreme Court opinions regarding nuclear regulation. The Court frequently acts as policymaker through the consequences of its opinions, if not by its intent. In the area of nuclear policymaking, the Court has paid allegiance recently both to the tradition of centralization and to the movement toward decentralization. This dualism is reflected in other federal court decisions as well which will be briefly mentioned. Continuing the analysis of Federal regulation, Section 3 examines the current reform efforts of the NRC. Section 4 presents an examination of State responses to nuclear plant cancellations. In this section, State administrative agency and court decisions will be examined and recent State legislation will be discussed. (author)

  14. Nuclear regulation in transition

    Energy Technology Data Exchange (ETDEWEB)

    Tomain, J.P. (Cincinnati Univ., OH, US. Coll. of Law)

    1986-01-01

    The current state of nuclear regulations in the USA is examined. Since Three Mile Island the regulation of the nuclear power industry has been undergoing a noticeable transition. It will be argued here that the transition is characterized by two indicia. First, the primary focus of state and federal regulators has been on the financial aspects of the industry: this is best seen in the context of decisions allocating the costs of nuclear plant cancellations. Second, decisionmaking power has been decentralized: although the regulatory history of nuclear power demonstrates the tradition of centralized decisionmaking power (i.e., formerly the primary decisionmaking body was the Atomic Energy Commission), now States share decisionmaking power with the Nuclear Regulatory Commission. In Section 1 a brief legislative history of nuclear regulation is presented to establish the assertion that nuclear regulation, both de jure and de facto, was centralized. Next, Section 2 canvasses recent United States Supreme Court opinions regarding nuclear regulation. The Court frequently acts as policymaker through the consequences of its opinions, if not by its intent. In the area of nuclear policymaking, the Court has paid allegiance recently both to the tradition of centralization and to the movement toward decentralization. This dualism is reflected in other federal court decisions as well which will be briefly mentioned. Continuing the analysis of Federal regulation, Section 3 examines the current reform efforts of the NRC. Section 4 presents an examination of State responses to nuclear plant cancellations. In this section, State administrative agency and court decisions will be examined and recent State legislation will be discussed.

  15. La práctica del paisajismo

    Directory of Open Access Journals (Sweden)

    Medina Muro, María

    2010-12-01

    Full Text Available The practice of landscaping is best understood by looking at who the contemporary designers are what work they do and in what professional realm they operate. If we take into account the range of possibilities a landscape architect has —from work on projects that take place in the wilderness to rural and urban environments— one can go from designing a small interior patio to projects that hace major environmental impact. Based on my knowledge and professional experience I am going to focus mainly on the types of landscapes I have been able to develop; the restoration of historic gardens, urban landscapes and private gardens, making reference to and showing examples of the works of other professionals in the field. In conclusion I will underline the importance of gardens and the relationship between ecology and the traditions of landscape design.

    La práctica del paisajismo se entiende mejor si se aclara quién es hoy un paisajista, en que ámbito profesional puede trabajar, y cuáles son sus obras. Si tenemos en cuenta la posibilidad que tiene un paisajista de actuar o participar en trabajos que abarcan tanto el paisaje natural, el rural como el urbano, su ámbito de trabajo puede ser muy amplio: desde diseñar un pequeño patio a realizar un estudio de impacto medioambiental. Me voy a referir preferentemente, y basándome en mis conocimientos y experiencia profesional, a aquellos paisajes que en la práctica he podido desarrollar: restauración de jardines y paisajes históricos; paisajes urbanos; y jardines privados, citando y mostrando algunos ejemplos de trabajos realizados por profesionales del paisaje. Por último, destacaré la importancia de los jardines y la relación entre ecología y tradición en la práctica del paisajismo. [fr] La pratique du l’aménagement paysager est mieux comprise en précisant qui est aujourd’hui un paysagiste, dans lequel cadre professionnel peut travailler, et quelles sont ses oeuvres. Si

  16. À jamais, à présent

    OpenAIRE

    Pierrepont, Alexandre

    2007-01-01

    L’objet de cet article serait de rendre compte de quelques-unes des lignes de vie de cette expérience musicale nommée « jazz », telles qu’elles se sont prolongées au cours des trois dernières décennies, particulièrement aux États-Unis. Interroger la manière avec laquelle la transmission (de parole, de présences, de jeux et d’intelligences) se fait alors et aujourd’hui, dans quelles conditions, sous quelles pressions peut-être, à partir de quels constats ou de quelles intuitions, comment en dé...

  17. (Prérif central, Maroc septentrional

    Directory of Open Access Journals (Sweden)

    Abdelghani Gartet

    2005-01-01

    Full Text Available El artículo tiene por objeto evaluar la degradación específi ca, y especialmente cuantifi car la carga de transporte sólido, en la cuenca del oued Lebène (Prérif central, caracterizada por altas tasas de erosión hídrica. La fuerte erosionabilidad de las rocas, la agresividad climática y las frecuentes variaciones de caudal hacen que el volumen de los materiales transportados por el Lebène alcancen una magnitud considerable. La irregularidad espacio-temporal de las precipitaciones y caudales condicionan el volumen de los transportes sólidos, de ahí las estrechas correlaciones existentes entre las tres variables. Los análisis relativos a la turbidez de las aguas y a la naturaleza granulométrica de los sedimentos refuerzan dicha relación.

  18. Computerbasiert prüfen [Computer-based Assessment

    Directory of Open Access Journals (Sweden)

    Frey, Peter

    2006-08-01

    Full Text Available [english] Computer-based testing in medical education offers new perspectives. Advantages are sequential or adaptive testing, integration of movies or sound, rapid feedback to candidates and management of web-based question banks. Computer-based testing can also be implemented in an OSCE examination. In e-learning environments formative self-assessment are often implemented and gives helpful feedbacks to learners. Disadvantages in high-stake exams are the high requirements as well for the quality of testing (e.g. standard setting as additionally for the information technology and especially for security. [german] Computerbasierte Prüfungen im Medizinstudium eröffnen neue Möglichkeiten. Vorteile solcher Prüfungen liegen im sequentiellen oder adaptiven Prüfen, in der Integration von Bewegtbildern oder Ton, der raschen Auswertung und zentraler Verwaltung der Prüfungsfragen via Internet. Ein Einsatzgebiet mit vertretbarem Aufwand sind Prüfungen mit mehreren Stationen wie beispielsweise die OSCE-Prüfung. Computerbasierte formative Selbsttests werden im Bereiche e-learning häufig angeboten. Das hilft den Lernenden ihren Wissensstand besser einzuschätzen oder sich mit den Leistungen anderer zu vergleichen. Grenzen zeigen sich bei den summativen Prüfungen beim Prüfungsort, da zuhause Betrug möglich ist. Höhere ärztliche Kompetenzen wie Untersuchungstechnik oder Kommunikation eigenen sich kaum für rechnergestützte Prüfungen.

  19. Thermodynamic database for the Co-Pr system

    Directory of Open Access Journals (Sweden)

    S.H. Zhou

    2016-03-01

    Full Text Available In this article, we describe data on (1 compositions for both as-cast and heat treated specimens were summarized in Table 1; (2 the determined enthalpy of mixing of liquid phase is listed in Table 2; (3 thermodynamic database of the Co-Pr system in TDB format for the research articled entitle Chemical partitioning for the Co-Pr system: First-principles, experiments and energetic calculations to investigate the hard magnetic phase W. Keywords: Thermodynamic database of Co-Pr, Solution calorimeter measurement, Phase diagram Co-Pr

  20. Triinu rukkileib nimetati Baltimaade parimaks PR-projektiks

    Index Scriptorium Estoniae

    2014-01-01

    Leiburi leivatehase ja kommunikatsioonibüroo Hamburg ja Partnerid ühisprojekt "Leiburi Leivategu" nimetati üleeuroopalisel pr-spetsialistide konkursil 2013. a. parimaks kommunikatsiooniprojektiks Baltimaades

  1. Electrocardiographic PR-interval duration and cardiovascular risk

    DEFF Research Database (Denmark)

    Rasmussen, Peter Vibe; Nielsen, Jonas Bille; Skov, Morten Wagner

    2017-01-01

    Background Because of ambiguous reports in the literature, we aimed to investigate the association between PR interval and the risk of all-cause and cardiovascular death, heart failure, and pacemaker implantation, allowing for a nonlinear relationship. MethodsWe included 293,111 individuals...... into 7 groups based on the population PR interval distribution. Cox models were used, with reference to a PR interval between 152 and 161 ms (40th to heart failure...... adjustment. A long PR interval conferred an increased risk of heart failure ( > 200 ms; HR, 1.31; 95% CI, 1.22-1.42; P 200 ms (HR, 3...

  2. Israel: a crise próxima

    Directory of Open Access Journals (Sweden)

    Peter DEMANT

    2014-12-01

    Full Text Available Apesar de êxitos indisputáveis, o Estado de Israel enfrenta problemas estruturais decorrentes do conflito com o mundo árabe. O texto analisa cinco vulnerabilidades subestimadas: (1 demografia: o crescimento dos ultraortodoxos e dos árabes israelenses, ambos antissionistas, que arrisca tornar minoria os judeus sionistas; (2 estratégia: novas formas de resistência usadas pelos árabes, tanto militares, como os mísseis, quanto pacíficas, como a resistência não violenta, estão progressivamente se tornando contraproducentes à ocupação israelense de territórios inimigos; (3 regional: a Primavera Árabe, apesar dos fracassos, é uma etapa na democratização e modernização das sociedades árabes que acabará erodindo a vantagem qualitativa-educacional israelense; (4 internacional: Israel depende, militar e economicamente, do apoio ocidental, mas, movidos por seus próprios desenvolvimentos demográficos e culturais, os europeus se mostram cada vez mais indiferentes ou hostis a Israel; e até nos EUA, último reduto de simpatia pró-israelense, a identificação com o Estado judaico pode se tornar mais frágil; (5 mundo judaico: devido à orientação cada vez mais particularista de Israel, há, em vez de legitimação recíproca, ameaça de alienação entre as diásporas judaicas e Israel. O artigo conclui que, a termo, as custas políticas, militares e socioculturais que a beligerância permanente impõe a Israel podem constituir um risco existencial para este país. Eventualmente, os dilemas podem se tornar perigosos para sua sobrevivência como Estado judaico.

  3. FDA regulations for commercial food irradiation

    International Nuclear Information System (INIS)

    Takeguchi, C.A.

    1985-01-01

    The Food and Drug Administration published an Advance Notice of Proposed Rulemaking (ANPR) on food irradiation on March 27, 1981 (FDA, 1981). The next step in the rulemaking process is a proposed rule that will deal with low-dose irradiation of certain foods and high-dose irradiation of spices. The status of the proposed regulation is discussed

  4. Electronic structures of PrBa2Cu3O7, Pr2Ba4Cu7O15-y(y=0,1), and PrBa2Cu4O8 based on LSDA+U method

    International Nuclear Information System (INIS)

    Tavana, A.; Shirazi, M.; Akhavan, M.

    2009-01-01

    The electronic structures of PrBa 2 Cu 3 O 7 (Pr123), Pr 2 Ba 4 Cu 7 O 15-y (Pr247), and PrBa 2 Cu 4 O 8 (Pr124) cuprates have been obtained using density-functional theory in the local spin density approximation plus onsite Coulomb interaction (LSDA+U). Onsite Hubbard correlation, U, has been considered for Pr-f and Cu-d orbitals and the effects of considering these correlation corrections on the Pr-O hybridizations have been inspected. Results imply that the Pr ionization state in Pr123 system is constituted from two different configurations, and the energy of the f states in these two configurations has an important role in superconductivity properties of the system. Our calculations also show that in both Pr124 and Pr247 systems, suppression of superconductivity is weaker than that in the Pr123 system. This occurs due to the weaker Pr-O bond in both Pr124 and Pr247 systems. The role of the double chain and single chain on the conduction properties of these compounds has been investigated. We have also studied the effect of oxygen deficiency in Pr247 system, which seems to revive superconductivity in this system. Investigating the hole carriers in the CuO 2 plane shows a correlation between superconductivity suppression and hole decrement in the planes. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

  5. 7 CFR 301.75-6 - Interstate movement of regulated nursery stock from a quarantined area.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Interstate movement of regulated nursery stock from a... Citrus Canker Notice of Quarantine and Regulations § 301.75-6 Interstate movement of regulated nursery stock from a quarantined area. (a) Regulated nursery stock may not be moved interstate from a...

  6. Comparative NMR study of nPrBTP and iPrBTP

    Energy Technology Data Exchange (ETDEWEB)

    Adam, C.; Muellich, U.; Geist, A.; Geckeis, H. [Karlsruhe Institute of Technology - KIT, Institute for Nuclear Waste Disposal - INE, Herrmann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); Rohde, V. [Fraunhofer Institute for Chemical Technology - ICT, Environmental Engineering, Joseph-von-Fraunhofer-Str. 7, 76327 Pfinztal (Germany); Kaden, P. [Helmholtz-Zentrum Dresden - Rossendorf e. V., Institute of Resource Ecology, Bautzner Landstrasse 400, 01328 Dresden (Germany); Panak, P.J. [Karlsruhe Institute of Technology - KIT, Institute for Nuclear Waste Disposal - INE, Herrmann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany); University of Heidelberg, Department of Physical Chemistry, Im Neuenheimer Feld 253, 69120 Heidelberg (Germany)

    2016-07-01

    Bis-triazinyl-pyridine type ligands are important extracting agents for separating trivalent actinide ions from trivalent lanthanides. The alkyl substituents on the lateral triazine rings have a significant effect on the stability of the ligand against hydrolysis and radiolysis. Furthermore they influence solubility, extraction behaviour and selectivity. TRLFS and extraction studies suggest differences in complexation and extraction behaviour of BTP ligands bearing iso-propyl or n-propyl substituents, respectively. As NMR studies allow insight into the metal-ligand bonding, we conducted NMR studies on a range of {sup 15}N-labelled nPrBTP and iPrBTP Ln(III) and Am(III) complexes. Our results show that no strong change in the metal-ligand bonding occurs, thus excluding electronic reasons for differences in complexation behaviour, extraction kinetics and selectivity. This supports mechanistic reasons for the observed differences. (authors)

  7. Teoria e prática das práticas alternativas

    Directory of Open Access Journals (Sweden)

    Fernando D. de Avila-Pires

    1995-04-01

    Full Text Available São abordados, os fundamentos científicos e a ética da utilização das práticas de medicina alternativa em voga no Brasil. Ressalta-se que, em geral, o termo alternativo não é definido e que pode se referir aos princípios básicos ou aos métodos de diagnóstico e tratamento. Sugere-se que a escolha individual de um sistema terapêutico é mais influenciada por fatores culturais, pela tradição familiar e pela moda, do que pela análise racional dos seus fundamentos. Estabelece-se que o que distingue realmente os diferentes sistemas são seus princípios e não suas práticas.

  8. Teoria e prática das práticas alternativas

    Directory of Open Access Journals (Sweden)

    Avila-Pires Fernando D. de

    1995-01-01

    Full Text Available São abordados, os fundamentos científicos e a ética da utilização das práticas de medicina alternativa em voga no Brasil. Ressalta-se que, em geral, o termo alternativo não é definido e que pode se referir aos princípios básicos ou aos métodos de diagnóstico e tratamento. Sugere-se que a escolha individual de um sistema terapêutico é mais influenciada por fatores culturais, pela tradição familiar e pela moda, do que pela análise racional dos seus fundamentos. Estabelece-se que o que distingue realmente os diferentes sistemas são seus princípios e não suas práticas.

  9. Présentation du volume

    Directory of Open Access Journals (Sweden)

    Ana Zwitter Vitez

    2012-12-01

    Full Text Available Dans de nombreuses disciplines scientifiques, le discours parlé représente depuis quelques décennies un objet de recherche proéminent. Ce fait s’explique probablement par deux caractéristiques principales du discours parlé: la structure complexe de sa matérialité et les fonctions variées de différentes pratiques langagières. C’est pourquoi le présent numéro réunit les articles basés sur les approches actuelles du discours parlé et sur les pratiques langagières spécifiques. Le volume est introduit par deux articles interdisciplinaires: Peter Garrard et Ahmed Samrah présentent le domaine de la pathologie du langage en donnant une revue fouillée sur les approches actuelles de l’analyse linguistique lors de la détection de la maladie d’Alzheimer, tandis que Harry Hollien donne un aperçu structuré sur le domaine de la phonétique judiciaire destiné à dévoiler l’identité des locuteurs et de détecter la déception dans le discours parlé. Les analyses explorant l’acquisition du langage commencent par l’article de Katharina Zipser qui examine la progression de structures grammaticales en les mettant en comparaison avec la compétence des apprenants et continuent par l’étude de Meta Lah proposant une évaluation des documents audiovisuels proposés aux apprenants de langue étrangère. Vesna Požgaj Hadži, Damir Horga et Tatjana Balažic Bulc remettent en question la corrélation entre la compétence linguistique et la fluence linguistique auprès de locuteurs non-maternels et l'analyse de Gemma Santiago Alonso aborde l'acquisition de l'article défini dans le langage enfantin. Les articles suivants se réunissent autour du domaine de l'interprétation: Jana Zidar Forte présente une approche actuelle dans l'entrainement d'interprètes, Lea Burjan analyse les phénomènes issus de la pratique de l'interprétation juridique et Simona  Šumrada traite de la reformulation dans le discours de la traduction et de

  10. Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C.

    Directory of Open Access Journals (Sweden)

    Chae Kim

    Full Text Available The mammalian prions replicate by converting cellular prion protein (PrP(C into pathogenic conformational isoform (PrP(Sc. Variations in prions, which cause different disease phenotypes, are referred to as strains. The mechanism of high-fidelity replication of prion strains in the absence of nucleic acid remains unsolved. We investigated the impact of different conformational characteristics of PrP(Sc on conversion of PrP(C in vitro using PrP(Sc seeds from the most frequent human prion disease worldwide, the Creutzfeldt-Jakob disease (sCJD. The conversion potency of a broad spectrum of distinct sCJD prions was governed by the level, conformation, and stability of small oligomers of the protease-sensitive (s PrP(Sc. The smallest most potent prions present in sCJD brains were composed only of∼20 monomers of PrP(Sc. The tight correlation between conversion potency of small oligomers of human sPrP(Sc observed in vitro and duration of the disease suggests that sPrP(Sc conformers are an important determinant of prion strain characteristics that control the progression rate of the disease.

  11. Production of no-carrier-added 139Pr via precursor decay in the proton bombardment of natPr

    International Nuclear Information System (INIS)

    Steyn, G.F.; Vermeulen, C.; Nortier, F.M.; Szelecsenyi, F.; Kovacs, Z.; Qaim, S.M.

    2006-01-01

    Excitation functions and production rates are presented for various Pr and Nd radionuclides formed in the bombardment of Pr with protons, from their respective thresholds up to 100 MeV. The indirect production route 141 Pr(p, 3n) 139m Nd → 139 Pr is investigated as an alternative to the direct production route 140 Ce(p, 2n) 139 Pr for producing no-carrier-added 139 Pr of high radionuclidic purity. The simultaneous production of 139 Pr and 140 Nd using Pr as target is investigated. The advantages and disadvantages of both production routes are discussed. Experimental thick-target production rates are presented for selected Pr radionuclides formed in the bombardment of nat Ce with protons at incident energies of 20, 26 and 32 MeV. All the experimental excitation functions obtained in this work are compared with theoretical predictions by means of the geometry-dependent hybrid (GDH) model as implemented in the code ALICE-IPPE. The results of this work are also compared with previous literature experimental data, if available

  12. Phosphorus and Cu2+ removal by periphytic biofilm stimulated by upconversion phosphors doped with Pr3+-Li.

    Science.gov (United States)

    Zhu, Yan; Zhang, Jianhong; Zhu, Ningyuan; Tang, Jun; Liu, Junzhuo; Sun, Pengfei; Wu, Yonghong; Wong, Po Keung

    2018-01-01

    Upconversion phosphors (UCPs) can convert visible light into luminescence, such as UV, which can regulate the growth of microbes. Based on these fundamentals, the community composition of periphytic biofilms stimulated by UCPs doped with Pr 3+ -Li + was proposed to augment the removal of phosphorus (P) and copper (Cu). Results showed that the biofilms with community composition optimized by UCPs doped with Pr 3+ -Li + had high P and Cu 2+ removal rates. This was partly due to overall bacterial and algal abundance and biomass increases. The synergistic actions of algal, bacterial biomass and carbon metabolic capacity in the Pr-Li stimulated biofilms facilitated the removal of P and Cu 2+ . The results show that the stimulation of periphytic biofilms by lanthanide-doped UCPs is a promising approach for augmenting P and Cu 2+ removal. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Biro Konsultan PR dan Kompetensi Praktisi PR di Era Industrialisasi Komunikasi dan Pencitraan

    Directory of Open Access Journals (Sweden)

    Dina Sekar Vusparatih

    2013-04-01

    Full Text Available The world of communication starts to experience rapid development in various aspects of life, almost all over the world. In Indonesia, it is marked by the emergence of a lot of tv and radio stations, and started the trend of imaging strategy efforts that is used to win the regional election, nasional election, and even to win marketing competition through company’s products or services image branding. This phenomenon is the opportunity for PR consultants to be successful team in designing appropriate communication strategies and appropriate steps to build the image. This opportunity is used by many people which is characterized by the proliferation of consultancies. Competition between consultants becomes so tight considering the companies or organizations that intend to hire consultants also want the best. Competitive bidding process was conducted, to win this, it needs solid team of consultants required in skills and morally. PR competencies of each member are needed to grow into a successful PR consultant. 

  14. RIZ Tumor and Breast Cancer: The PR Domain

    National Research Council Canada - National Science Library

    Aznar-Derunes, Celine

    2005-01-01

    .... RIZ is the founding member of the PR-domain family of zinc finger genes. Two protein products are produced from the RIZ gene which differ by the presence or the absence of the PR domain: RIZ1 and RIZ2...

  15. Case Studies in e-RPL and e-PR

    Science.gov (United States)

    Cameron, Roslyn; Miller, Allison

    2014-01-01

    The use of ePortfolios for recognition of prior learning (e-RPL) and for professional recognition (e-PR) is slowly gaining in popularity in the VET sector however their use is sporadic across educational sectors, disciplines, educational institutions and professions. Added to this is an array of purposes and types of e-RPL and e-PR models and…

  16. 33 CFR 161.20 - Position Report (PR).

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Position Report (PR). 161.20 Section 161.20 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... Report (PR). A vessel must report its name and position: (a) Upon point of entry into a VMRS area; (b) At...

  17. RIZ Tumor Suppressor and Breast Cancer: The PR Domain

    National Research Council Canada - National Science Library

    Aznar-Derunes, Celine

    2004-01-01

    .... RIZ is the founding member of the PR-domain family of zinc finger genes. Two protein products are produced from the RIZ gene which differ by the presence or the absence of the PR domain : RIZ1 and RIZ2...

  18. The role of e-PR in foreign policy

    Directory of Open Access Journals (Sweden)

    Tereshchuk Vitaliy Ivanovych

    2015-10-01

    Full Text Available The article discusses the role of the Internet as a global communication tool in the PR-support of the implementation of foreign policy. Special attention is paid to such innovative directions of electronic foreign PR as the creation of "virtual embassies" (on the example of the United States.

  19. Incorporation of Pr into LuAG ceramics

    Science.gov (United States)

    Marchewka, M. R.; Chapman, M. G.; Qian, H.; Jacobsohn, L. G.

    2017-06-01

    An investigation of the effects of Pr in (Lu1-xPrx)3Al5O12 (LuAG:Pr) ceramics was carried out by means of x-ray diffraction (XRD), energy dispersive x-ray spectroscopy (EDX), and attenuated total reflection Fourier transform infrared spectroscopy (ATR FTIR) measurements coupled with luminescence measurements. It was found that the Pr concentration that maximizes luminescence emission depends on the thermal processing conditions. While the calcined LuAG:Pr powder showed maximum luminescence emission for Pr concentrations between 0.18 and 0.33 at.%, maximum emission of ceramic bodies sintered at 1500 °C for 20 h was obtained with Pr concentrations between 0.018 and 0.18 at.%. Further, for short sintering times up to about 3 h, luminescence emission intensity is maximum for Pr concentrations around 0.33 at.%. Longer sintering times lead to the formation of PrAlO3 as a secondary phase, concomitant with a reduction of the intensity of luminescence emission.

  20. PrP-C1 fragment in cattle brains reveals features of the transmissible spongiform encephalopathy associated PrPsc.

    Science.gov (United States)

    Serra, Fabienne; Müller, Joachim; Gray, John; Lüthi, Ramona; Dudas, Sandor; Czub, Stefanie; Seuberlich, Torsten

    2017-03-15

    Three different types of bovine spongiform encephalopathy (BSE) are known and supposedly caused by distinct prion strains: the classical (C-) BSE type that was typically found during the BSE epidemic, and two relatively rare atypical BSE types, termed H-BSE and L-BSE. The three BSE types differ in the molecular phenotype of the disease associated prion protein, namely the N-terminally truncated proteinase K (PK) resistant prion protein fragment (PrP res ). In this study, we report and analyze yet another PrP res type (PrP res-2011 ), which was found in severely autolytic brain samples of two cows in the framework of disease surveillance in Switzerland in 2011. Analysis of brain tissues from these animals by PK titration and PK inhibitor assays ruled out the process of autolysis as the cause for the aberrant PrP res profile. Immunochemical characterization of the PrP fragments present in the 2011 cases by epitope mapping indicated that PrP res-2011 corresponds in its primary sequence to the physiologically occurring PrP-C1 fragment. However, high speed centrifugation, sucrose gradient assay and NaPTA precipitation revealed biochemical similarities between PrP res-2011 and the disease-associated prion protein found in BSE affected cattle in terms of detergent insolubility, PK resistance and PrP aggregation. Although it remains to be established whether PrP res-2011 is associated with a transmissible disease, our results point out the need of further research on the role the PrP-C1 aggregation and misfolding in health and disease. Copyright © 2017. Published by Elsevier B.V.

  1. Energy transfer between Pr3+ and Mn2+ in K2YZr(PO4)3: Pr, Mn phosphor

    International Nuclear Information System (INIS)

    Liang Wei; Wang Yuhua

    2011-01-01

    Research highlights: → Pr 3+ , Mn 2+ co-doped K 2 YZr(PO 4 ) 3 phosphor is a novel type of practical visible quantum cutting phosphor in promising application. → The optimal quantum efficiency (QE) of this co-doped system K 2 YZr(PO 4 ) 3 : Pr 3+ , Mn 2+ reached to 126.3%. → The Mn 2+6 A 1g → 4 E g - 4 A 1g transition was found to coincide well with the 1 S 0 → 1 I 6 transition of Pr 3+ . → The energy transfer from Pr 3+ to Mn 2+ was also observed, converting the first photon from the PCE of Pr 3+ into the red emission of Mn 2+ , and the QC process occurred in this Pr 3+ , Mn 2+ co-doped K 2 YZr(PO 4 ) 3 phosphor. - Abstract: Pr 3+ , Mn 2+ co-doped K 2 YZr(PO 4 ) 3 samples were prepared by solid-state reaction method and their photoluminescence (PL) properties were investigated in ultra-violet (UV) and vacuum ultra-violet (VUV) region. The results indicated that in Pr 3+ singly doped K 2 YZr(PO 4 ) 3 sample, the first-step transition ( 1 S 0 → 1 I 6 , 3 P J around 405 nm) of Pr 3+ is near the ultraviolet (UV) range, not useful for practical application. When Mn 2+ was doped as a co-activator ion, the energy of 1 S 0 → 1 I 6 , 3 P J transition can be transferred synchronously from Pr 3+ to Mn 2+ and then emit a visible photon. The optimal quantum efficiency (QE) of this co-doped system K 2 YZr(PO 4 ) 3 : Pr 3+ , Mn 2+ reached to 126.3%, suggesting a novel type of practical visible quantum cutting phosphor in promising application.

  2. 7 CFR 319.56-1 - Notice of quarantine.

    Science.gov (United States)

    2010-01-01

    ... quarantine. (a) Under section 412(a) of the Plant Protection Act, the Secretary of Agriculture may prohibit... 7 Agriculture 5 2010-01-01 2010-01-01 false Notice of quarantine. 319.56-1 Section 319.56-1 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION...

  3. 24 CFR 100.75 - Discriminatory advertisements, statements and notices.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Discriminatory advertisements, statements and notices. 100.75 Section 100.75 Housing and Urban Development Regulations Relating to Housing and Urban Development OFFICE OF ASSISTANT SECRETARY FOR EQUAL OPPORTUNITY, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT FAIR HOUSING DISCRIMINATOR...

  4. 26 CFR 1.853-3 - Notice to shareholders.

    Science.gov (United States)

    2010-04-01

    ... respect to the holders of interest in the unit investment trust, it shall so notify the Internal Revenue... Internal Revenue Service that the regulated investment company has failed to comply with the agreement... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Notice to shareholders. 1.853-3 Section 1.853-3...

  5. 7 CFR 900.306 - Notice of the referendum.

    Science.gov (United States)

    2010-01-01

    ... Conduct of Referenda To Determine Producer Approval of Milk Marketing Orders To Be Made Effective Pursuant to Agricultural Marketing Agreement Act of 1937, as Amended § 900.306 Notice of the referendum. (a... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing...

  6. 18 CFR 286.103 - Notice to audited person.

    Science.gov (United States)

    2010-04-01

    ... COMMISSION, DEPARTMENT OF ENERGY OTHER REGULATIONS UNDER THE NATURAL GAS POLICY ACT OF 1978 AND RELATED... conducted by the Commission's staff under authority of the Natural Gas Policy Act may result in a notice of...: A filed tariff or tariffs, contracts, data, records, accounts, books, communications or papers...

  7. 10 CFR 2.106 - Notice of issuance.

    Science.gov (United States)

    2010-01-01

    ... previously published. (d) The Director of Nuclear Material Safety and Safeguards will also cause to be... Application-How Initiated § 2.106 Notice of issuance. (a) The Director, Office of New Reactors, Director, Office of Nuclear Reactor Regulation, or Director, Office of Nuclear Material Safety and Safeguards, as...

  8. 76 FR 51064 - National Science Board; Sunshine Act Meetings; Notice

    Science.gov (United States)

    2011-08-17

    ... NATIONAL SCIENCE FOUNDATION National Science Board; Sunshine Act Meetings; Notice The National Science Board (NSB) Committee on Audit and Oversight and the NSB Committee on Strategy and Budget, pursuant to NSF regulations (45 CFR part 614), the National Science Foundation Act, as amended (42 U.S.C...

  9. 75 FR 48996 - National Science Board; Sunshine Act Meetings; Notice

    Science.gov (United States)

    2010-08-12

    ... NATIONAL SCIENCE FOUNDATION National Science Board; Sunshine Act Meetings; Notice The National Science Board's Committee on Audit & Oversight, pursuant to NSF regulations (45 CFR part 614), the National Science Foundation Act, as amended (42 U.S.C. 1862n-5), and the Government in the Sunshine Act (5...

  10. 76 FR 3180 - National Science Board; Sunshine Act Meetings; Notice

    Science.gov (United States)

    2011-01-19

    ... NATIONAL SCIENCE FOUNDATION National Science Board; Sunshine Act Meetings; Notice The National Science Board's Committee on Programs and Plans and the Committee on Audit & Oversight, pursuant to NSF regulations (45 CFR part 614), the National Science Foundation Act, as amended (42 U.S.C. 1862n-5), and the...

  11. 14 CFR 272.7 - Notice of discontinuance of service.

    Science.gov (United States)

    2010-01-01

    ... PROCEEDINGS) ECONOMIC REGULATIONS ESSENTIAL AIR SERVICE TO THE FREELY ASSOCIATED STATES § 272.7 Notice of... of essential air service for such place, the level of service specified in Order 80-9-63; and (2) If the Department has made a determination of essential air service for such place, that level of...

  12. 77 FR 6095 - Notice of Submission for OMB Review

    Science.gov (United States)

    2012-02-07

    ... note that written comments received in response to this notice will be considered public records...: Teacher Education Assistance for College and Higher Education (TEACH) Grant Eligibility Regulations. OMB... Number when making your request. Individuals who use a telecommunications device for the deaf (TDD) may...

  13. 29 CFR Appendix A to Part 801 - Notice to Examinee

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Notice to Examinee A Appendix A to Part 801 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION... your rights or protections under the law are violated, you have the right to file a complaint with the...

  14. 75 FR 11898 - Notice of Cancellation of Customs Broker License

    Science.gov (United States)

    2010-03-12

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker License AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security... 1641), and the U.S. Customs and Border Protection regulations (19 CFR 111.51(b)), the following Customs...

  15. 77 FR 5819 - Notice of Cancellation of Customs Broker Licenses

    Science.gov (United States)

    2012-02-06

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker Licenses AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.51), the following Customs...

  16. 75 FR 5618 - Notice of Cancellation of Customs Broker License

    Science.gov (United States)

    2010-02-03

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker License AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.51(b)), the following Customs...

  17. 76 FR 7873 - Notice of Cancellation of Customs Broker License

    Science.gov (United States)

    2011-02-11

    ... DEPARTMENT OF HOMELAND SECURITY Customs and Border Protection Notice of Cancellation of Customs Broker License AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security. ACTION...), and the U.S. Customs and Border Protection regulations (19 CFR 111.51(b)), the following Customs...

  18. 77 FR 43609 - Notice of Cancellation of Customs Broker Licenses

    Science.gov (United States)

    2012-07-25

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker Licenses AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security.... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.53), the following Customs...

  19. 76 FR 44032 - Notice of Cancellation of Customs Broker Licenses

    Science.gov (United States)

    2011-07-22

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker Licenses AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security.... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.51), the following Customs...

  20. 75 FR 47825 - Notice of Cancellation of Customs Broker License

    Science.gov (United States)

    2010-08-09

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker License AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security.... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.51(b)), the following Customs...

  1. 75 FR 76998 - Notice of Cancellation of Customs Broker Licenses

    Science.gov (United States)

    2010-12-10

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker Licenses AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security.... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.51), the following Customs...

  2. 77 FR 74022 - Notice of Cancellation of Customs Broker License

    Science.gov (United States)

    2012-12-12

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker License AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION...) and the U.S. Customs and Border Protection regulations (19 CFR 111.51), the following Customs broker...

  3. 76 FR 2918 - Notice of Cancellation of Customs Broker Licenses

    Science.gov (United States)

    2011-01-18

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker Licenses AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security.... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.51), the following Customs...

  4. 75 FR 11899 - Notice of Cancellation of Customs Broker Licenses

    Science.gov (United States)

    2010-03-12

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker Licenses AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security.... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.51), the following Customs...

  5. 76 FR 13205 - Notice of Cancellation of Customs Broker Licenses

    Science.gov (United States)

    2011-03-10

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker Licenses AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security.... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.45), the following Customs...

  6. 75 FR 75691 - Notice of Cancellation of Customs Broker License

    Science.gov (United States)

    2010-12-06

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker License AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security.... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.45), the following Customs...

  7. 75 FR 47825 - Notice of Cancellation of Customs Broker Licenses

    Science.gov (United States)

    2010-08-09

    ... DEPARTMENT OF HOMELAND SECURITY U.S. Customs and Border Protection Notice of Cancellation of Customs Broker Licenses AGENCY: U.S. Customs and Border Protection, U.S. Department of Homeland Security... 1641) and the U.S. Customs and Border Protection regulations (19 CFR 111.51), the following Customs...

  8. 31 CFR 210.13 - Notice to account owners.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Notice to account owners. 210.13 Section 210.13 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE FEDERAL GOVERNMENT PARTICIPATION IN THE...

  9. 77 FR 52599 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2012-08-30

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of temporary... regulation that governs the Tower Drawbridge across Sacramento River, mile 59.0, at Sacramento, CA. The... change to the operation of the Tower Drawbridge, mile 59.0, over Sacramento River, at Sacramento, CA. The...

  10. 78 FR 23489 - Drawbridge Operation Regulation; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2013-04-19

    ... Operation Regulation; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of deviation... operating regulation that governs the Tower Drawbridge across Sacramento River, mile 59.0, at Sacramento, CA... Tower Drawbridge, mile 59.0, over Sacramento River, at Sacramento, CA. The Tower Drawbridge navigation...

  11. 78 FR 15879 - Drawbridge Operation Regulations; Sacramento River, Sacramento, CA

    Science.gov (United States)

    2013-03-13

    ... Operation Regulations; Sacramento River, Sacramento, CA AGENCY: Coast Guard, DHS. ACTION: Notice of... operating regulation that governs the Tower Drawbridge across the Sacramento River, mile 59.0, at Sacramento, CA. The deviation is necessary to allow the community to participate in the First Annual ``Biggest...

  12. 78 FR 39830 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-07-02

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... the Ozone Layer and on Products Containing Such Chemicals. OMB Number: 1545-1153. Regulation Project...

  13. 78 FR 45614 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-07-29

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... GST Deemed Allocations. OMB Number: 1545-1892. Regulation Project Number: REG-153841-02 (TD 9208...

  14. 78 FR 76892 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2013-12-19

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Liabilities for Pension Funding Purposes. OMB Number: 1545-2095. Regulation Project Number: REG-139236-07 (TD...

  15. 75 FR 2930 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2010-01-19

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service [REG-106446-98] Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and... From Joint and Several Liability. OMB Number: 1545-1719. Regulation Project Number: REG-106446-98...

  16. 76 FR 74117 - Proposed Collection; Comment Request for Regulation Project

    Science.gov (United States)

    2011-11-30

    ... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Regulation Project AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... Number: 1545-0817. Regulation Project Number: EE-28-78 (TD 7845). Abstract: Internal Revenue Code section...

  17. 77 FR 63725 - Drawbridge Operation Regulations; Old River, Orwood, CA

    Science.gov (United States)

    2012-10-17

    ... BNSF Middle River drawbridge as an alternative path for navigation. DATES: The temporary deviation... Operation Regulation; Old River, Orwood CA'' in the Federal Register (77 FR 58491). The temporary deviation... Operation Regulations; Old River, Orwood, CA AGENCY: Coast Guard, DHS. ACTION: Notice of cancellation of a...

  18. 76 FR 13312 - Drawbridge Operation Regulations; Fox River, Oshkosh, WI

    Science.gov (United States)

    2011-03-11

    ...-AA09 Drawbridge Operation Regulations; Fox River, Oshkosh, WI AGENCY: Coast Guard, DHS. ACTION: Notice... National Railway Bridge across the Fox River at Mile 55.72 at Oshkosh, Wisconsin. After careful... On December 8, 2010, we published an NPRM entitled Drawbridge Operation Regulation; Fox River...

  19. 77 FR 10960 - Drawbridge Operation Regulation; Snake Creek, Islamorada, FL

    Science.gov (United States)

    2012-02-24

    ... Operation Regulation; Snake Creek, Islamorada, FL AGENCY: Coast Guard, DHS. ACTION: Notice of temporary... deviation from the regulation governing the operation of Snake Creek Bridge, mile 0.5, across Snake Creek... schedule of Snake Creek Bridge in Islamorada, Florida. This deviation will result in the bridge opening...

  20. 77 FR 37316 - Drawbridge Operation Regulations; Reynolds Channel, Nassau, NY

    Science.gov (United States)

    2012-06-21

    ... Regulations; Reynolds Channel, Nassau, NY AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from... regulations governing the operation of the Long Beach Bridge, mile 4.7, across Reynolds Channel, at Nassau...: The Long Beach Bridge, across Reynolds Channel, mile 4.7, at Nassau, New York, has a vertical...

  1. 78 FR 26508 - Drawbridge Operation Regulations; Reynolds Channel, Nassau, NY

    Science.gov (United States)

    2013-05-07

    ... Regulations; Reynolds Channel, Nassau, NY AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from... regulation governing the operation of the Long Beach Bridge, mile 4.7, across Reynolds Channel at Nassau, New.... on July 12, 2013. Reynolds Creek has commercial and recreational vessel traffic. No objections were...

  2. 78 FR 66265 - Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY

    Science.gov (United States)

    2013-11-05

    ... Regulations; Reynolds Channel, Lawrence, NY AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation... from the regulations governing the operation of the Atlantic Beach Bridge, mile 0.4, across Reynolds.... SUPPLEMENTARY INFORMATION: The Atlantic Beach Bridge, across Reynolds Channel, mile 0.4, at Lawrence, New York...

  3. 78 FR 56609 - Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY

    Science.gov (United States)

    2013-09-13

    ... Regulations; Reynolds Channel, Lawrence, NY AGENCY: Coast Guard, DHS. ACTION: Notice canceling temporary... Beach Bridge, mile 0.4, across Reynolds Channel, at Lawrence, New York. The owner of the bridge, Nassau... published a temporary deviation entitled ``Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY...

  4. 78 FR 37456 - Drawbridge Operation Regulations; Reynolds Channel, Nassau, NY

    Science.gov (United States)

    2013-06-21

    ... Regulations; Reynolds Channel, Nassau, NY AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation from... regulation governing the operation of the Long Beach Bridge, mile 4.7, across Reynolds Channel at Nassau, New... July 1, 2013. Reynolds Creek has commercial and recreational vessel traffic. No objections were...

  5. 78 FR 34893 - Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY

    Science.gov (United States)

    2013-06-11

    ... Regulations; Reynolds Channel, Lawrence, NY AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation... from the regulations governing the operation of the Atlantic Beach Bridge, mile 0.4, across Reynolds... Reynolds Channel, mile 0.4, at Lawrence, New York, has a vertical clearance in the closed position of 25...

  6. 78 FR 56610 - Drawbridge Operation Regulations; Reynolds Channel, Lawrence, NY

    Science.gov (United States)

    2013-09-13

    ... Regulations; Reynolds Channel, Lawrence, NY AGENCY: Coast Guard, DHS. ACTION: Notice of temporary deviation... from the regulations governing the operation of the Atlantic Beach Bridge, mile 0.4, across Reynolds.... SUPPLEMENTARY INFORMATION: The Atlantic Beach Bridge, across Reynolds Channel, mile 0.4, at Lawrence, New York...

  7. National Credit Regulator versus Dedbank Ltd and the practice of ...

    African Journals Online (AJOL)

    The National Credit Regulator approached the then Transvaal Provincial Division of the High Court in 2008 by way of a notice of motion. In this application the Regulator prayed in terms of section 16(1)(b) of the National Credit Act 34 of 2005 (the "NCA") for the proper interpretation of mainly sections 86 and 87 of the same ...

  8. 7 CFR 301.86-2 - Regulated articles.

    Science.gov (United States)

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pale Cyst Nematode § 301.86-2 Regulated articles. The following are regulated articles: (a) Pale cyst nematodes.2 2 Permit and other requirements for the interstate movement of pale cyst nematodes are contained in part 330 of this chapter. (b) The...

  9. 77 FR 12754 - Contractor Legal Management Requirements; Acquisition Regulations

    Science.gov (United States)

    2012-03-02

    ... DEPARTMENT OF ENERGY 10 CFR Part 719 48 Parts 931, 952 and 970 RIN 1990-AA37 Contractor Legal... rulemaking (NOPR) to revise existing regulations covering contractor legal management requirements and make... relating to the DOE notice of proposed rulemaking to revise existing regulations covering contractor legal...

  10. 78 FR 18221 - Disclosures at Automated Teller Machines (Regulation E)

    Science.gov (United States)

    2013-03-26

    ... Disclosures at Automated Teller Machines (Regulation E) AGENCY: Bureau of Consumer Financial Protection... the EFTA to eliminate a requirement that a fee notice be posted on or at automated teller machines... legislation, though the Electronic Fund Transfer Act and Regulation E use the term ``automated teller machine...

  11. Digitale prøver – et litteraturstudie

    Directory of Open Access Journals (Sweden)

    Karen Louise Møller

    2015-10-01

    Full Text Available Digitale prøveformer bliver efterhånden mere og mere udbredte. Denne artikel er baseret på et litteraturstudie foretaget for at få indsigt i primært forskningslitteraturen om digitale prøveformer. I artiklen præsenterer vi de forskellige typer digitale prøver, der omtales og diskuteres i litteraturen, og vi beskriver de potentielle fordele af bl.a. økonomisk, administrativ og pædagogisk karakter, der ifølge litteraturen kan opnås ved at bruge digitale prøver. Vi beskriver endvidere de udfordringer og potentielle ulemper, der kan være forbundet med indførelse af digitale prøver. Det drejer sig bl.a. om udfordringer hvad angår prøvesystem, organisation, teknologi, kompetenceudvikling og uddannelseskultur. Vi beskriver i artiklen en række konkrete eksempler på digitale prøver, og vi præsenterer resultater fra undersøgelser af underviseres og studerendes oplevelser med digitale prøveformer. Against the backdrop of the rapid spread of digitized tests and exams, this article sets out to present some of the results of a literature study carried out with the aim of gaining insight into the research literature on this topic. The article presents different types of tests, focusing on the financial, administrative, and pedagogical advantages described and discussed in the literature as potentially attainable through the use of digitized exams. In addition, the challenges and potential problems connected with the introduction of digitized tests are described. Among these are challenges related to the test system or to competence development as well as organizational, technological, and cultural challenges. Finally, the article provides concrete descriptions of tests and presents results from select studies of teacher and student experiences of digitized tests.

  12. ER and PR expression and survival after endometrial cancer.

    Science.gov (United States)

    Smith, Deborah; Stewart, Colin J R; Clarke, Edward M; Lose, Felicity; Davies, Claire; Armes, Jane; Obermair, Andreas; Brennan, Donal; Webb, Penelope M; Nagle, Christina M; Spurdle, Amanda B

    2018-02-01

    To measure association between endometrial carcinoma ER and PR status and endometrial cancer (EC) survival, accounting for inter-observer variation. The intensity and proportion of tumor cell expression of ER and PR in ECs were assessed independently and semi-quantitatively by two pathologists using digital images of duplicate tumor tissue microarrays (TMAs). Cases with inconsistent initial assessment were reviewed and final scoring agreed. The association between overall and EC-specific survival and hormone receptor expression (intensity, proportion and combined) was assessed using Cox regression analysis. The C-index was used to evaluate model discrimination with addition of ER and PR status. Tumor ER and PR analysis was possible in 659 TMAs from 255 patients, and in 459 TMAs from 243 patients, respectively. Initial ER and PR scoring was consistent in 82% and 80% of cases, respectively. In multivariate analyses decreased ER and PR expression was associated with increased tumor-related mortality. Associations reached statistical significance for ER proportion score (P=0.05), ER intensity score (P=0.003), and PR combined score (P=0.04). Decreased expression of combined ER/PR expression was associated with poorer EC-specific survival than decreased expression of either hormone receptor alone (P=0.005). However, hormone receptor status did not significantly improve mortality prediction in individual cases. ER and PR expression combined, using cut-points that capture variation in scoring and across cores, is significantly associated with EC-specific survival in analyses adjusting for known prognostic factors. However, at the individual level, ER and PR expression does not improve mortality prediction. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Test og prøvelser

    DEFF Research Database (Denmark)

    Test i forskellige former og afskygninger spiller i dag en markant rolle indenfor mange forskellige områder i samfundet. De bliver anvendt til at evaluere og bedømme børn, unge og voksne i forskellige kontekster og med forskellige formål og konsekvenser. I mange tilfælde er der tale om test, hvis...... udfald – direkte eller indirekte - vil kunne få vidtrækkende følger for dem, der testes. Test kan sætte sig spor livet igennem og udsætte de testede for prøvelser, idet de påvirker deres selvopfattelser og udstikker bestemte livsbaner og muligheder. Med afsæt i uddannelsesområdet sætter denne bog fokus...... på test i historisk og nutidig belysning. Den behandler spørgsmål som: Hvordan kom test ind i feltet? Hvilke test anvendes? Hvem tester man? Hvorfor vil man gerne teste? Hvad er de direkte og indirekte sociale konsekvenser af at anvende test? Besvarelsen af disse spørgsmål kan på den ene side bidrage...

  14. (Prérif Central, Maroc septentrional

    Directory of Open Access Journals (Sweden)

    Abdelghani Gartet

    2006-01-01

    Full Text Available El diapiro de sal de Tissa, situado en el Prerif central marroquí, afl ora en una zona de contacto estructural anormal donde la morfogénesis kárstica es muy activa. La solubilidad de las formaciones del complejo triásico es excesivamente fuerte. El macizo yesífero-salino representa un yacimiento de sal gema casi inagotable. Sin embargo, las aguas de Oued Lebène, en época de crecidas, socavan intensamente la base del macizo y terminan siendo afectadas por la contaminación química. La explotación de la cantera de sal, siendo tradicional, plantea numerosos problemas de planifi cación, a la vez que atenta severamente contra el medio ambiente (natural y urbano y contra la sociedad humana. Las medidas de defensa del medio ambiente adoptadas al respecto resultan por el momento insufi cientes dada la falta de una legislación práctica y rigurosa.

  15. The Japanese PR and PP program

    International Nuclear Information System (INIS)

    Senzaki, Masao; Inoue, Naoko; Kuno, Yusuke

    2008-01-01

    Japan has established the commercial nuclear fuel cycle with LWR as a non-weapon state, and now has been developing RF fuel cycle as the next generation technology. Japanese studies on proliferation resistance have started in 1990's by JNC, predecessor concern of JAEA. The early study was focused on the intrinsic features of Pu and safeguards technologies. Based on TOPS report, JNC has developed a quantitative assessment methodology and modified it by JNC designers. JNC and JAEA intends to play the role as a hub that contributes international collaborative study such as GEN IV PR and PP Experts Group and INPRO based on Japanese experiences of safeguards and nonproliferation efforts, and feedback to domestic experts. These efforts include not only the contribution into those programs, but also introduce these activities to Japanese domestic experts, holding international workshops, symposiums as a 'Hub' of domestic and international experts. This paper will introduce the Japanese Proliferation Resistance studies including, the early studies, international workshops/symposiums, the study in FaCT, international collaboration studies, and the future direction identified for the nuclear fuel cycle systems. (author)

  16. 77 FR 68102 - Foreign-Trade Zone 163-Ponce, PR; Application for Subzone; Zimmer Manufacturing BV; Ponce, PR

    Science.gov (United States)

    2012-11-15

    ... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-81-2012] Foreign-Trade Zone 163--Ponce, PR; Application for Subzone; Zimmer Manufacturing BV; Ponce, PR An application has been submitted to the Foreign-Trade Zones Board (the Board) by CODEZOL, C.D., grantee of FTZ 163, requesting special- purpose subzone...

  17. 76 FR 78638 - Elba Express Company, L.L.C; Notice of Intent To Prepare an Environmental Assessment for the...

    Science.gov (United States)

    2011-12-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. CP12-11-000] Elba Express Company, L.L.C; Notice of Intent To Prepare an Environmental Assessment for the Proposed Coldwater Compressor Station Project, Request for Comments on Environmental Issues, and Notice of Public Scoping Meeting The staff of the Federal Energy Regulator...

  18. 77 FR 25193 - Notice of Availability of the Draft Environmental Impact Statement for the Lost Creek Uranium In...

    Science.gov (United States)

    2012-04-27

    ...-166318] Notice of Availability of the Draft Environmental Impact Statement for the Lost Creek Uranium In... (EIS) for the Lost Creek Uranium In Situ Recovery (ISR) Project and by this notice is announcing the... subpart 3809 regulations to construct a uranium ore recovery plant, an access road to the site, and a...

  19. 75 FR 77034 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-12-10

    ...-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate Effectiveness of..., notice is hereby given that on December 3, 2010, The NASDAQ Stock Market LLC (``Nasdaq'' or ``Exchange...) Pricing Obligations. For NMS stocks (as defined in Rule 600 under Regulation NMS) a Market Maker shall...

  20. 48 CFR 352.234-1 - Notice of earned value management system-pre-award Integrated Baseline Review.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Notice of earned value management system-pre-award Integrated Baseline Review. 352.234-1 Section 352.234-1 Federal Acquisition... provision: Notice of Earned Value Management System—Pre-Award Integrated Baseline Review (October 2008) The...

  1. 48 CFR 352.234-2 - Notice of earned value management system-post-award Integrated Baseline Review.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Notice of earned value management system-post-award Integrated Baseline Review. 352.234-2 Section 352.234-2 Federal Acquisition... provision: Notice of Earned Value Management System—Post-Award Integrated Baseline Review (October 2008) (a...

  2. 76 FR 62409 - Notice of Proposals To Engage in Permissible Nonbanking Activities or To Acquire Companies That...

    Science.gov (United States)

    2011-10-07

    ... notice have given notice under the Home Owners' Loan Act (HOLA) (12 U.S.C. 1461 et seq.), and Regulation...) of HOLA (12 U.S.C. 1467a(c)(4)(B)). Unless otherwise noted, comments regarding the applications must...

  3. 76 FR 58812 - Notice of Proposals To Engage in Permissible Nonbanking Activities or To Acquire Companies That...

    Science.gov (United States)

    2011-09-22

    ... notice have given notice under the Home Owners' Loan Act (HOLA) (12 U.S.C. 1461 et seq.), and Regulation...) of HOLA (12.U.S.C. 1467a(c)(4)(B)). Unless otherwise noted, comments regarding the applications must...

  4. 78 FR 26099 - Notice Seeking Exemption Under the Small Business Investment Act, Conflicts of Interest; VPC SBIC...

    Science.gov (United States)

    2013-05-03

    ..., Conflicts of Interest; VPC SBIC I, LP; License No. 05/05-0308 Notice is hereby given that VPC SBIC I, LP... Conflicts of Interest of the Small Business Administration (``SBA'') Rules and Regulations (13 CFR 101730... Associate requiring prior SBA approval. Notice is hereby given that any interested person may submit written...

  5. 78 FR 13885 - Notice of HUD-Held Multifamily & Healthcare Loan Sale, Second Offering (MHLS 2013-1)

    Science.gov (United States)

    2013-03-01

    ...-708-2625, extension 3927. Hearing- or speech-impaired individuals may call 202-708-4594 (TTY). These... are eligible to submit bids on the Mortgage Loans in the second offering for MHLS 2013- 1. Freedom of... the Freedom of Information Act and all regulations promulgated thereunder. Scope of Notice This notice...

  6. Praseodymium valency from crystal structure in Pr-Ba-Cu-O and (Y-Pr)-Ba-Cu-O single crystals

    International Nuclear Information System (INIS)

    Collin, G.; Albouy, P.A.; Monod, P.; Ribault, M.

    1990-01-01

    The substitution of Pr to Y leads to materials with a general formula (Y 1-v Pr v ) (Ba 2-x Pr x ) (Cu 3-y vac y ) O 6+x/2-y+z and with a structural transition around v + x' ∼ 0.5. For v + x 0.5 the crystals are tetragonal, La 1.5 Ba 1.5 Cu 3 O 7±z type, with the characteristic tri-twinning of this phase. The Pr valency, in the range 3-3.2 + depending on preparation conditions, is determined from interatomic distances. Orthorhombic crystals of Pr Ba Cu O prepared at high temperatures exhibit a high amount of defects, y ∼ 0.25 on the Cu(1) site and are semiconductors with a T -1/4 activation law attributed to the praseodymium valence fluctuation

  7. PrEP Whores and HIV Prevention: The Queer Communication of HIV Pre-Exposure Prophylaxis (PrEP).

    Science.gov (United States)

    Spieldenner, Andrew

    2016-12-01

    HIV pre-exposure prophylaxis (PrEP) has been introduced as another biomedical tool in HIV prevention. Whereas other such tools-including post-exposure prophylaxis (PEP) and interruption of perinatal transmission-have been embraced by those impacted by HIV, PrEP has been met with more conflict, especially within the gay community and HIV organizations. The "PrEP whore" has come to designate the social value and personal practices of those taking PrEP. This study examines the "PrEP whore" discourse by using queer theory and quare theory. Within these theoretical vantage points, the study explicates four discursive areas: slut shaming, dirty/clean binaries, mourning the loss of condoms, and reclaiming the inner whore. The study illuminates possible discursive strategies that lie outside of the domains of public health and within the individual and community.

  8. On the nature of the dhcp to fcc transition under pressure in Pr and Pr-Th alloys

    International Nuclear Information System (INIS)

    Vijayakumar, V.; Godwal, B.K.; Sikka, S.K.; Chidambaram, R.

    1988-01-01

    The results of electrical resistance (R), thermoelectric power (TEP) and X-ray diffraction measurements on praseodymium (Pr) and its alloys with thorium under pressure are reported. The maximum in R vs P curve exhibited by Pr persists only in the dhcp phase of Pr-Th alloy. X-ray measurements confirmed that in the alloys also the maximum in R vs P curve is due to the dhcp → fcc transition. Thus the behaviour of Pr and Pr-Th alloys is different from that of La and its alloys with Ce and Th where the maximum in the R vs P curve is electronic in origin and is exhibited by the dhcp, fcc and dist fcc phases. (author). 14 refs

  9. Novas conformações metodológicas em relação à jurimetria: discussão teórica e implicações práticas para a regulação de preços no Brasil / New Methodological Contours regarding Jurimetrics: Theoretical Discussion and Practical Implications to Brazilian Price Regulation

    Directory of Open Access Journals (Sweden)

    Ricardo Medeiros de Castro

    2015-04-01

    Full Text Available Purpose – This paper discusses how quantitative methods can be used to improve the understanding of juridical phenomena. As research hypothesis, this article maintains that this methodology is not frequently used in Brazilian Law, which, in turn, prevents the diagnosis of social injustices, hinders the improvement of institutions, makes it harder to discuss burden of proof and overshadows the debate of price regulation. Methodology – After a review of the literature on the theoretical debate about the subject, this study takes an econometric approach, using 5 models, to verify if Brazilian Legal Academic Research uses quantitative language. Also, it identifies what would be the impact on society resulted from a quantitative-silence on Legal Studies. Findings – None of 1,723 thesis of Legal Academic Research made any Econometric regression. There was a low level of quantitative discussion in the analyzed sample. This finding is particularly problematic, especially in Brazil, where quantitative debate is needed to prevent some unfair legal standards, which in turn hinders the improvement of society, even in regulatory aspects. Practical implications – The article sheds light on the need to foster an interdisciplinary agenda between Law and Econometrics.

  10. Plant Reliability - an Integrated System for Management (PR-ISM)

    International Nuclear Information System (INIS)

    Aukeman, M.C.; Leininger, E.G.; Carr, P.

    1984-01-01

    The Toledo Edison Company, located in Toledo, Ohio, United States of America, recently implemented a comprehensive maintenance management information system for the Davis-Besse Nuclear Power Station. The system is called PR-ISM, meaning Plant Reliability - An Integrated System for Management. PR-ISM provides the tools needed by station management to effectively plan and control maintenance and other plant activities. The PR-ISM system as it exists today consists of four integrated computer applications: equipment data base maintenance, maintenance work order control, administrative activity tracking, and technical specification compliance. PR-ISM is designed as an integrated on-line system and incorporates strong human factors features. PR-ISM provides each responsible person information to do his job on a daily basis and to look ahead towards future events. It goes beyond 'after the fact' reporting. In this respect, PR-ISM is an 'interactive' control system which: captures work requirements and commitments as they are identified, provides accurate and up-to-date status immediately to those who need it, simplifies paperwork and reduces the associated time delays, provides the information base for work management and reliability analysis, and improves productivity by replacing clerical tasks and consolidating maintenance activities. The functional and technical features of PR-ISM, the experience of Toledo Edison during the first year of operation, and the factors which led to the success of the development project are highlighted. (author)

  11. Selective recognition of Pr3+ based on fluorescence enhancement sensor

    International Nuclear Information System (INIS)

    Ganjali, M.R.; Hosseini, M.; Ghafarloo, A.; Khoobi, M.; Faridbod, F.; Shafiee, A.; Norouzi, P.

    2013-01-01

    (E)-2-(1-(4-hydroxy-2-oxo-2H-chromen-3-yl)ethylidene) hydrazinecarbothioamide (L) has been used to detect trace amounts of praseodymium ion in acetonitrile–water solution (MeCN/H 2 O) by fluorescence spectroscopy. The fluorescent probe undergoes fluorescent emission intensity enhancement upon binding to Pr 3+ ions in MeCN/H 2 O (9/1:v/v) solution. The fluorescence enhancement of L is attributed to a 1:1 complex formation between L and Pr 3+ , which has been utilized as the basis for selective detection of Pr 3+ . The sensor can be applied to the quantification of praseodymium ion with a linear range of 1.6 × 10 −7 to 1.0 × 10 −5 M. The limit of detection was 8.3 × 10 −8 M. The sensor exhibits high selectivity toward praseodymium ions in comparison with common metal ions. The proposed fluorescent sensor was successfully used for determination of Pr 3+ in water samples. - Highlights: • A new fluorescent sensor is introduced as a selective probe for Pr 3+ detection. • Fluorescent intensity of the chemical probe enhances upon binding to Pr 3+ ion. • The sensor can be used for Pr 3+ determination in the range of 1.6 × 10 −7 –1.0 × 10 −5 M

  12. ETR fuel element shipping container addendum to PR-T-79-011 (TR-466). Internal technical report

    International Nuclear Information System (INIS)

    Smith, M.C.

    1979-01-01

    In July, 1979, EG and G Idaho, Inc. was requested to evaluate the ETR Fuel Element Shipping Container for compliance with existing transport regulations, in order to ship GETR fuel elements from Vallecitos, California to the INEL. Technical report PR-T-79-011 (TR-466), ATR Fuel Element Shipping Container Safety Analysis, was used as a basis for this evaluation. The safety analysis contained in technical report PR-T-79-011 (TR-466) was performed utilizing the ATR, ETR, MTR, and SPERT shipping containers. The report determined the ETR Fuel Element Shipping Container does comply with the existing transport regulations for a Type A quantity, Fissile Class I shipping container. The ETR and GETR fuel elements are essentially identical in physical size, construction, and fissile material content, the analysis documented in this report has determined the shipment of GETR fuel elements in the ETR shipping container to be safe and pose no threat to the public health and safety

  13. 76 FR 81826 - Drawbridge Operation Regulation; Pocomoke River, Pocomoke City, MD

    Science.gov (United States)

    2011-12-29

    ... Operation Regulation; Pocomoke River, Pocomoke City, MD AGENCY: Coast Guard, DHS. ACTION: Notice of... River, mile 15.6, at Pocomoke City, MD. The deviation restricts the operation of the draw span to... five hours advance notice is given. The Route 675 Bridge across Pocomoke River, mile 15.6 at Pocomoke...

  14. 78 FR 20624 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

    Science.gov (United States)

    2013-04-05

    ... Identification Advance Shipment Notices AGENCY: Defense Acquisition Regulations System, Department of Defense (Do...) Whether the proposed collection of information is necessary for the proper performance of the functions of... at 252.211; Radio Frequency Identification Advance Shipment Notices, OMB Control Number 0704-0434...

  15. 75 FR 81125 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

    Science.gov (United States)

    2010-12-27

    ... Operation Regulation; Upper Mississippi River, Rock Island, IL AGENCY: Coast Guard, DHS. ACTION: Notice of... the Upper Mississippi River, mile 481.4, at Rock Island, Illinois. The deviation is necessary to allow... Rock Island, Illinois to open on signal if at least 24 hours advance notice is given for 44 days from...

  16. 77 FR 17352 - Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program

    Science.gov (United States)

    2012-03-26

    ...-AL97 Federal Acquisition Regulation; Women-Owned Small Business (WOSB) Program Correction In rule...) * * * -- (24) 52.219-29, Notice of Set-Aside for Economically Disadvantaged Women-Owned Small Business (EDWOSB... Disadvantaged Women- Owned Small Business Concerns. * * * * * Notice of Set-Aside for Economically Disadvantaged...

  17. Franchising a právo

    OpenAIRE

    Hampejsová, Jitka

    2013-01-01

    The thesis deals with legislative regulation of franchising in the Czech Republic and which areas of law have influence on franchise agreements and how is this relationship to other areas of law solved. The thesis focuses on content of franchise agreements, on typical provisons of franchise agreements according to antitrust law, on protection of intellectual property rights, on unfair competiton and on personal data protection. Some aspects are discussed according to laws of the USA and Germa...

  18. Las prácticas en el contexto comunicativo

    Directory of Open Access Journals (Sweden)

    Guillermo Orozco Gómez

    2015-01-01

    Full Text Available La comunicación debe ser entendida como proceso y producto de diversas prácticas sociales, cuyos componentes básicos son la sociabilidad, la ritualidad y la tecnicidad. Desde una perspectiva democrática, esas prácticas deben ser fortalecidas, especialmente en uno de sus aspectos esenciales: el diálogo y los "escenarios para ese diálogo". Actualmente el desafío radica en el fortalecimiento de las prácticas sociales -autónomas y democráticas- y especialmente de la comunicación, producto y componente de ellas.

  19. The PR-1 domain accounts for the anti-angiogenic activity of a cysteine-rich secretory protein member from the buccal glands of Lampetra japonica.

    Science.gov (United States)

    Duan, Dandan; Wang, Hongyan; Zhou, Rong; Jiang, Qi; Xiao, Rong

    2018-02-01

    Previous studies have shown that cysteine-rich buccal gland protein (CRBGP) from buccal glands of Lampetra japonica could suppress angiogenesis in chick chorioallantoic membrane models. As CRBGP is composed of a pathogenesis-related group 1 (PR-1) domain and a cysteine-rich domain (CRD), which domain accounts for the effects of CRBGP on anti-angiogenesis? In the present study, recombinant PR-1 and CRD (rL-PR-1 and rL-CRD) were obtained. MTT assays showed rL-PR-1 inhibited the proliferation of HUVECs significantly in a dose-dependent manner with an IC 50 of 2μM, while rL-CRD had no obviously inhibitory effect on the proliferation of HUVECs, suggested that PR-1 is the main function domain on the anti-angiogenic activity of CRBGP. Similar to CRBGP, rL-PR-1 induced apoptosis in HUVECs in a mitochondrial-dependent pathway by affecting the level of BAX, BCL2 and caspase 3. Also, the cytotoxic property of rL-PR-1 might be one of the factors which suppressed the proliferation of HUVECs. Furthermore, rL-PR-1 blocked the adhesion, migration, invasion and tube formation of HUVECs by disturbing the cytoskeleton arrangement and down-regulating the level of matrix metallo-peptidase 2. In summary, rL-PR-1 has the anti-angiogenic activity which would provide the information on the functions and mechanisms of cysteine-rich secretory protein family members. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. ÁREAS VERDES URBANAS IMAGEM E USO - O CASO DO PASSEIO PÚBLICO DE CURITIBA-PR

    Directory of Open Access Journals (Sweden)

    Silmara Dias FEIBER

    2004-12-01

    Full Text Available Com a finalidade de avaliar a importância das áreas verdes urbanas como agentes amenizadores dos impactos ambientais causados pela intensa intervenção do homem sobre o meio ambiente natural, a presente pesquisa tem por objetivo verificar este poder de amenização e usa como foco de análise os Parques Públicos Urbanos. Procura-se para tanto buscar bases teóricas que dêem subsídio à pesquisa no sentido de avaliar como os cidadãos comuns através das práticas cotidianas percebem as áreas verdes, usam e traçam suas trajetórias que darão base ao desenvolvimento de uma imagem particular. Para dar sustentação à pesquisa, realizouse um estudo empírico no Passeio Público de Curitiba-PR, onde se pôde alcançar os objetivos propostos. Green urban areas image and use - the case of Passeio Público from Curitiba-PR Abstract In order to evaluate the importance of the green urban areas aiming at the reduction of the environmental impacts caused by man intense intervention over the natural environment, this paper checks this reduction power by analysing urban public parks. To achieve that goal, it brings theoretical bases that will subsidize the research in order to evaluate how the ordinary citizens, through daily practices, by noticing green areas, use and make their tracking, which will give means to develop a particular image. To support the research, an experimental study on Curitiba-PR public walk was held.

  1. Athletes as PR Spokespeople: the NFL’s “A Crucial Catch” PR Campaign Explored

    Directory of Open Access Journals (Sweden)

    Chyna Teresa Trible

    2015-06-01

    Full Text Available The results of the present study were presented at the 2015 International Conference on Communication and Management and examined the National Football League’s (NFL “A Crucial Catch” breast cancer awareness campaign in the United States. Variables included identification with NFL athletes, exposure to the campaign, NFL fanship, and intention to schedule a breast cancer screening (the action promoted by NFL athletes in this PR campaign. Social media outlets and an e-mail listserv of the School of Communication at Rochester Institute of Technology in Rochester, New York, USA were employed to solicit participants (n=119 in a survey. A questionnaire composed of items modified from Brown and Bocarnea’s (2007a Celebrity-Persona Parasocial Identification Scale to investigate identification with NFL athletes was used. Statistically significant relationships were found between identification with NFL athletes and exposure, identification with NFL athletes and intention to schedule a breast cancer screening, and identification with NFL athletes and NFL fanship. NFL fanship was also significantly related to exposure to the campaign. Implications for future studies analyzing PR campaigns produced by the NFL and FIFA are suggested.

  2. Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions.

    Science.gov (United States)

    Miyazawa, Kohtaro; Okada, Hiroyuki; Masujin, Kentaro; Iwamaru, Yoshifumi; Yokoyama, Takashi

    2015-01-01

    Disease-related prion protein (PrP(Sc)), which is a structural isoform of the host-encoded cellular prion protein, is thought to be a causative agent of transmissible spongiform encephalopathies. However, the specific role of PrP(Sc) in prion pathogenesis and its relationship to infectivity remain controversial. A time-course study of prion-affected mice was conducted, which showed that the prion infectivity was not simply proportional to the amount of PrP(Sc) in the brain. Centrifugation (20,000 ×g) of the brain homogenate showed that most of the PrP(Sc) was precipitated into the pellet, and the supernatant contained only a slight amount of PrP(Sc). Interestingly, mice inoculated with the obtained supernatant showed incubation periods that were approximately 15 d longer than those of mice inoculated with the crude homogenate even though both inocula contained almost the same infectivity. Our results suggest that a small population of fine PrP(Sc) may be responsible for prion infectivity and that large, aggregated PrP(Sc) may contribute to determining prion disease duration.

  3. 78 FR 44922 - Vegetable and Specialty Crop Marketing Orders; Notice of Request for Extension and Revision of a...

    Science.gov (United States)

    2013-07-25

    ... Approved Information Collection AGENCY: Agricultural Marketing Service, USDA. ACTION: Notice and request... assured of consideration. Additional Information or Comments: Contact Andrew Hatch, Supervisory Marketing....regulations.gov . SUPPLEMENTARY INFORMATION: Title: Vegetable and Specialty Crop Marketing Orders. OMB Number...

  4. 76 FR 50286 - Request for Comments and Notice of Public Hearing Concerning China's Compliance With WTO Commitments

    Science.gov (United States)

    2011-08-12

    ...., subsidies, standards and technical regulations, sanitary and phytosanitary measures, government procurement... Concerning China's Compliance With WTO Commitments AGENCY: Office of the United States Trade Representative. ACTION: Request for comments and notice of public hearing concerning China's compliance with its WTO...

  5. 78 FR 58568 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-09-24

    ... certain animals and certain geographic areas a requiring special protection. The regulations establish such a permit system to designate Antarctic Specially Protected Areas. Application Details 1. Applicant... NATIONAL SCIENCE FOUNDATION Notice of Permit Applications Received Under the Antarctic...

  6. 78 FR 53789 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Science.gov (United States)

    2013-08-30

    ... certain animals and certain geographic areas a requiring special protection. The regulations establish such a permit system to designate Antarctic Specially Protected Areas. Application Details 1. Applicant... NATIONAL SCIENCE FOUNDATION Notice of Permit Applications Received Under the Antarctic...

  7. Cathodoluminescence properties of SiO2:Pr3+and ZnO.SiO2:Pr3+ phosphor nanopowders

    CSIR Research Space (South Africa)

    Mhlongo, GH

    2010-10-01

    Full Text Available regardless of the incorporation of Pr3+ and nanocrystalline ZnO or annealing at 600 °C. The particles were mostly spherical and agglomerated as confirmed by Field Emission Scanning Electron Microscopy. Thermogravimetric analysis of dried gels performed... Science, vol. 45(19): 5228-5236 Cathodoluminescence properties of SiO2:Pr 3+and ZnO·SiO2:Pr 3+ phosphor nanopowders G. H. Mhlongo, O. M. Ntwaeaborwa, M. S. Dhlamini, H. C. Swart, K. T. Hillie ABSTRACT: The successful incorporation of Zn...

  8. Paramagnetic probes to study PrNi5?

    International Nuclear Information System (INIS)

    Hutchinson, W.D.; Harker, S.J.; Stewart, G.A.; Chaplin, D.H.; Kaplan, N.

    1996-01-01

    The Van-Vleck paramagnet PrNi 5 has been the focus of many studies in the past as a result of its usefulness as a nuclear cooling agent. Extensive continuous wave praseodymium NMR measurements have been carried out on this compound. However pulsed NMR and therefore precise relaxation measurements particularly at mK temperatures have proved elusive. In this work we have proposed to use radiative gamma-ray detection to indirectly measure Pr NMR in PrNi 5 via cross relaxation to suitable paramagnetic impurity probes placed at Ni lattice sites. 57 Co was chosen as the most compatible nuclear orientation isotope with an appropriate nuclear g-factor. The choice of 57 Co also allows the use of Moessbauer spectroscopy to check the site occupancy. This poster details the production of a 57 Co doped PrNi 5 single crystal specimen including the specimen preparation problems encountered, 57 Fe Moessbauer and preliminary nuclear orientation measurements

  9. High Ra, high Pr convection with viscosity gradients

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. High Ra, high Pr convection with viscosity gradients. Weak upward flow through mesh. Top fluid more viscous. Unstable layer Instability Convection.

  10. Study of positive parity bands in 137Pr

    International Nuclear Information System (INIS)

    Agarwal, Priyanka; Kumar, Suresh; Jain, A.K.; Singh, Sukhjeet; Malik, S.S.; Sinha, Rishi Kumar; Dhal, Anukul; Chaturvedi, L.; Muralithar, S.; Singh, R.P.; Madhavan, N.; Kumar, Rakesh; Bhowmik, R.K.; Pancholi, S.C.; Jain, H.C.

    2006-01-01

    In this paper the analysis and interpretation of the positive parity states in 137 Pr have been reported. The detailed interpretation with configuration assignments and the calculations for the bands will be reported

  11. Characterization and optical properties of Pr2O3-doped ...

    Indian Academy of Sciences (India)

    2017-06-09

    Jun 9, 2017 ... Pr3+ doped molybdenum lead-borate glasses with the chemical ... Thermal, optical and structural analyses are carried out using DSC, UV and FTIR spectra. ... energy band gap (Egopt), of these glasses have been determined.

  12. Právo a marketing

    OpenAIRE

    Šebek, Marcel

    2011-01-01

    The aim of this thesis is to analyse legal regulations of marketing and advertising in the Czech Republic as well as in the European context and define possibilities of applications of marketing methods and tools in the field of legal services. This is followed by a detailed elaboration for advocacy being the most marketable branch within this field. Based on the analysis of classic marketing mix tools, the aim is to create a set of marketing instruments suitable for the selected field of adv...

  13. PrEP implementation research in Africa: what is new?

    Science.gov (United States)

    Cowan, Frances M; Delany-Moretlwe, Sinead; Sanders, Eduard J; Mugo, Nelly R; Guedou, Fernand A; Alary, Michel; Behanzin, Luc; Mugurungi, Owen; Bekker, Linda-Gail

    2016-01-01

    Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM), transgender women and injection drug users) are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW) are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. In each of the target populations, there are overarching issues related to (i) creating demand for PrEP, (ii) addressing supply-side issues and (iii) providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely to have an important influence

  14. Legal notice in a nuclear plant

    International Nuclear Information System (INIS)

    Anon.

    1975-01-01

    By decision of 5-2-75 - 4 SA 234/74 -, the Frankfurt regional labour court has confirmed the legal notice to quit given to a machinist working in a nuclear plant by his employer. In spite of a previous instruction on safety regulations, the man had twice parked his private car on an escape route to be kept clear, and, in spite of an explicit order, had not moved his car. The main grounds upon which the judgment of the court was based are presented in the article. (HP/AK) [de

  15. Radiation regulation

    International Nuclear Information System (INIS)

    Braithwaite, J.; Grabosky, P.

    1985-01-01

    The five main areas of radiation regulation considered are radiation exposure in the mining of uranium and other minerals, exposure in the use of uranium in nuclear reactors, risks in the transport of radioactive materials and hazards associated with the disposal of used materials. In Australia these problems are regulated by mines departments, the Australian Atomic Energy Commission and radiation control branches in state health departments. Each of these instutional areas of regulation is examined

  16. Electronic structures of PrBa2Cu3O7 and PrBa2Cu4O8 systems based on LSDA+U approach

    International Nuclear Information System (INIS)

    Shirazi, M.; Tavana, A.; Akhavan, M.

    2007-01-01

    Full text: The electronic structures of PrBa 2 Cu 3 O 7 (Pr123) and PrBa 2 Cu 4 O 8 (Pr124) have been obtained by means of the density functional theory in the local spin density approximation plus on-site Coulomb interaction. The correlation correction has been applied to the Cu 3d and Pr 4f states. Calculations show that the localized Pr-O bands form near the Fermi surface and do not cross the Fermi level. Comparison of the hole absorbing ability of pfy and the pdy states shows that pfy state has dominant role in grabbing holes from the system and causes Pr124 to be non-superconducting like Pr123. We suggest that hybridization of Pr and O atoms in Pr124 system is weaker than Pr123 compound and this may be the reason for the higher critical doping of Pr by which the superconductivity is completely suppressed. Displacement of the conduction bands at the Fermi level is the criterion of Cu (3dx2-y2) character, and when Cu (3dx2-y2) character is stronger in a band, the band displaces more intensively under applying the correction Ucu. We estimate the hole-concentration from this displacement, and good agreement with experiment is seen. The displacement of the CuO 2 plane bands in the minority and majority spin channels in Pr124 is less than that in Pr123. Displacement of the double chain bands in Pr124 is higher than the single chain bands in Pr123. This feature is related to a stronger Cu (3dx2-y2) character in the double chain. So, the spin and conduction features of the Pr124 double chains are stronger than Pr123 single chain, which is the origin of metallic behavior of Pr124 at low temperatures. (authors)

  17. Electronic structures of PrBa2Cu3O7 and PrBa2Cu4O8 systems based on LSDA+U approach

    International Nuclear Information System (INIS)

    Shirazi, M.; Tavana, A.; Akhavan, M.

    2007-01-01

    Full text: The electronic structures of PrBa 2 Cu 3 O 7 (Pr123) and PrBa 2 Cu 4 O 8 (Pr124) have been obtained by means of the density functional theory in the local spin density approximation plus on-site Coulomb interaction. The correlation correction has been applied to the Cu 3d and Pr 4f states. Calculations show that the localized Pr-O bands form near the Fermi surface and do not cross the Fermi level. Comparison of the hole absorbing ability of pfy and the pdy states shows that pfy state has dominant role in grabbing holes from the system and causes Pr124 to be non-superconducting like Pr123. We suggest that hybridization of Pr and O atoms in Pr124 system is weaker than Pr123 compound and this may be the reason for the higher critical doping of Pr by which the superconductivity is completely suppressed. Displacement of the conduction bands at the Fermi level is the criterion of Cu (3dx2-y2) character, and when Cu (3dx2-y2) character is stronger in a band, the band displaces more intensively under applying the correction Ucu. We estimate the hole-concentration from this displacement, and good agreement with experiment is seen. The displacement of the CuO 2 plane bands in the minority and majority spin channels in Pr124 is less than that in Pr123. Displacement of the double chain bands in Pr124 is higher than the single chain bands in Pr123. This feature is related to a stronger Cu (3dx2-y2) character in the double chain. So, the spin and conduction features of the Pr124 double chains are stronger than Pr123 single chain, which is the origin of metallic behavior of Pr124 at low temperatures.(authors)

  18. Complejidad versus simplicidad en prótesis total removible

    OpenAIRE

    Escuin Henar, Tomás J. (Tomás José); Ferré de Guilarte, Antonio; Gascón Mayordomo, Francisco; Salsench Cabré, Juan

    1992-01-01

    En el presente trabajo valoramos los resultados a distancia (dos años) del método de elaboración de la Prótesis Total Removible, mediante la utilización de parámetros clínicos, con el fin de simplificar el proceso de elaboración de la Prótesis Total.

  19. Thermodynamic database for the Co-Pr system.

    Science.gov (United States)

    Zhou, S H; Kramer, M J; Meng, F Q; McCallum, R W; Ott, R T

    2016-03-01

    In this article, we describe data on (1) compositions for both as-cast and heat treated specimens were summarized in Table 1; (2) the determined enthalpy of mixing of liquid phase is listed in Table 2; (3) thermodynamic database of the Co-Pr system in TDB format for the research articled entitle Chemical partitioning for the Co-Pr system: First-principles, experiments and energetic calculations to investigate the hard magnetic phase W.

  20. Incommensurate magnetic ordering of PrPdAl

    Energy Technology Data Exchange (ETDEWEB)

    Keller, L. [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Doenni, A. [National Research Inst. for Metals, Tsukuba, Ibaraki (Japan). Tsukuba Lab.; Fauth, F. [Institut Max von Laue - Paul Langevin, 75 - Paris (France)

    1997-09-01

    The intermetallic rare earth compound PrPdAl with ZrNiAl-type structure was investigated by means of powder neutron diffraction. PrPdAl orders below T{sub N} {approx_equal}4.2 K with an incommensurate antiferromagnetic propagation vector k = [1/2,0,{tau}], {tau}=0.398. The best fit was obtained with a sinusoidal modulation of the magnetic moments along the c-axis. (author) 2 figs., 2 refs.