48 CFR 570.604 - Deviations to provisions and clauses.

Science.gov (United States)

2010-10-01

... modify the language of a provision or clause mandated by statute (e.g., GSAR 552.203-5, Covenant Against... for Disabled Veterans and Veterans of the Vietnam Era; and 52.222-36, Affirmative Action for Workers...

Preparing Safety Cases for Operating Outside Prescriptive Fatigue Risk Management Regulations.

Science.gov (United States)

Gander, Philippa; Mangie, Jim; Wu, Lora; van den Berg, Margo; Signal, Leigh; Phillips, Adrienne

2017-07-01

Transport operators seeking to operate outside prescriptive fatigue management regulations are typically required to present a safety case justifying how they will manage the associated risk. This paper details a method for constructing a successful safety case. The method includes four elements: 1) scope (prescriptive rules and operations affected); 2) risk assessment; 3) risk mitigation strategies; and 4) monitoring ongoing risk. A successful safety case illustrates this method. It enables landing pilots in 3-pilot crews to choose the second or third in-flight rest break, rather than the regulatory requirement to take the third break. Scope was defined using a month of scheduled flights that would be covered (N = 4151). These were analyzed in the risk assessment using existing literature on factors affecting fatigue to estimate the maximum time awake at top of descent and sleep opportunities in each break. Additionally, limited data collected before the new regulations showed that pilots flying at landing chose the third break on only 6% of flights. A prospective survey comparing subjective reports (N = 280) of sleep in the second vs. third break and fatigue and sleepiness ratings at top of descent confirmed that the third break is not consistently superior. The safety case also summarized established systems for fatigue monitoring, risk assessment and hazard identification, and multiple fatigue mitigation strategies that are in place. Other successful safety cases have used this method. The evidence required depends on the expected level of risk and should evolve as experience with fatigue risk management systems builds.Gander P, Mangie J, Wu L, van den Berg M, Signal L, Phillips A. Preparing safety cases for operating outside prescriptive fatigue risk management regulations. Aerosp Med Hum Perform. 2017; 88(7):688-696.

76 FR 71468 - Defense Federal Acquisition Regulation Supplement: Accelerate Small Business Payments (DFARS Case...

Science.gov (United States)

2011-11-18

... all small business concerns. In combination with the change to the regulations, DoD immediately began... Federal Acquisition Regulation Supplement: Accelerate Small Business Payments (DFARS Case 2011-D008... Regulation Supplement to accelerate payments to all small business concerns. DATES: Effective Date: November...

Cost of Capital in Price-regulated Companies: the Case of Estonia

Directory of Open Access Journals (Sweden)

Priit Sander

2013-01-01

Full Text Available In case of price-regulated companies it is the role of appropriate government agencies to introduce clear, internally consistent, theoretically sound, and unambiguous methodology for finding the regulative cost of capital. The aim of the paper is to describe and analyze the cost of capital estimation methodology for regulated companies in Estonia and discuss some issues arising in applying this methodology. The current paper focuses on two topical issues associated with the estimation of regulative cost of capital in Estonia: estimation of market risk premium and inclusion of currency risk premium into the cost of capital. Current turmoil in financial markets has increased investors’ risk aversion as well as level of risks.

77 FR 76446 - General Services Administration Acquisition Regulation (GSAR); Industrial Funding Fee (IFF) and...

Science.gov (United States)

2012-12-28

... Program cost recovery. In the past, this information was not formally communicated to MAS Program... government, as well as more accurately reflects the current MAS Program relative to use of the IFF. This..., public health and safety effects, distributive impacts, and equity). E.O. 13563 emphasizes the importance...

The effect of duty hour regulation on resident surgical case volume in otolaryngology.

Science.gov (United States)

Curtis, Stuart H; Miller, Robert H; Weng, Cindy; Gurgel, Richard K

2014-10-01

Evaluate the effect of duty hour regulation on graduating otolaryngology resident surgical case volume and analyze trends in surgical case volume for Accreditation Council for Graduate Medical Education (ACGME) key indicator cases from 1996 to 2011. Time-trend analysis of surgical case volume. Nationwide sample of otolaryngology residency programs. Operative logs from the American Board of Otolaryngology and ACGME for otolaryngology residents graduating in the years 1996 to 2011. Key indicator volumes and grouped domain volumes before and after resident duty hour regulations (2003) were calculated and compared. Independent t test was performed to evaluate overall difference in operative volume. Wilcoxon rank sum test evaluated differences between procedures per time period. Linear regression evaluated trend. The average total number of key indicator cases per graduating resident was 440.8 in 1996-2003 compared to 500.4 cases in 2004-2011, and overall average per number of key indicators was 31.5 and 36.2, respectively (P = .067). Four key indicator cases showed statistically significant (P otolaryngology residents. The overall trend in operative volume is increasing for several specific key indicators. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2014.

CORPORATE GOVERNANCE REGULATION IN EMERGING COUNTRIES. CASE OF ROMANIA

Directory of Open Access Journals (Sweden)

Claudiu George BOCEAN

2010-01-01

Full Text Available Most of the literature on corporate governance emphasizes that firms should be run in the interests of shareholders. This is a suitable objective function when markets are perfect and complete. In many emerging economies this is not the case: markets are imperfect and incomplete. Corporate governance issues are especially important in emerging countries, since these countries do not have the long-established financial institution infrastructure to deal with corporate governance issues. This paper discusses how emerging countries are dealing with corporate governance issues and the extra obstacles they have to overcome due to a lack of regulations. Romanian case study is examined.

A Case-Based Reasoning for Regulation of an Urban Transportation Network

Directory of Open Access Journals (Sweden)

Karim Bouamrane

2005-01-01

Full Text Available This paper presents a classification-based approach to case-based reasoning. This approach has been implemented in a decision-making system for regulating an urban transportation network. Planning relies on two classification processes: strong classification to retrieve a similar planning perturbation and smooth classification when the former fails. Smooth classification is an original mechanism that can become of general use in case-based reasoning. We discuss in this paper the two processes from general and applicative point of view.

A general model for CO2 regulation: the case of Denmark

DEFF Research Database (Denmark)

Svendsen, Gert Tinggaard

1998-01-01

For both economic, political, and administrative reasons, a mixed design of permit market, bubble and tax may be preferable for CO2 regulation. In the case of Denmark, a CO2 market should be introduced for the private manufacturing sector and an administratively set CO2 bubble should be introduced...

75 FR 34282 - Federal Acquisition Regulation; FAR Case 2009-013, Nonavailable Articles

Science.gov (United States)

2010-06-16

...-AL40 Federal Acquisition Regulation; FAR Case 2009-013, Nonavailable Articles AGENCIES: Department of... revise the list of articles determined to be domestically nonavailable. DATES: Effective Date: July 16.... SUPPLEMENTARY INFORMATION: A. Background The Buy American Act does not apply with respect to articles, materials...

75 FR 38675 - Federal Acquisition Regulation; FAR Case 2008-011, Government Property

Science.gov (United States)

2010-07-02

... contractor to use the property on an independent research and development (IR&D) program rent free, if-- (a... Government for all property acquired or fabricated by the Contractor in accordance with the financing...-0029; Sequence 1] RIN 9000-AL41 Federal Acquisition Regulation; FAR Case 2008-011, Government Property...

Cost-Benefit Analysis of Financial Regulation: Case Studies and Implications

OpenAIRE

Coates, John

2015-01-01

Some members of Congress, the D.C. Circuit, and legal academia are promoting a particular, abstract form of cost-benefit analysis for financial regulation: judicially enforced quantification. How would CBA work in practice, if applied to specific, important, representative rules, and what is the alternative? Detailed case studies of six rules – (1) disclosure rules under Sarbanes-Oxley Section 404, (2) the SEC’s mutual fund governance reforms, (3) Basel III’s heightened capital requirements f...

75 FR 26916 - Federal Acquisition Regulation: FAR Case 2009-004, Enhancing Contract Transparency

Science.gov (United States)

2010-05-13

... Regulation: FAR Case 2009-004, Enhancing Contract Transparency AGENCY: Department of Defense (DoD), General... commercial or financial information. This transparency effort is intended to promote efficiency in Government... the Administration's memorandum entitled Transparency and Open Government (January 21, 2009...

An empirical analysis of mental state talk and affect regulation in two single-cases of psychodynamic child therapy.

Science.gov (United States)

Halfon, Sibel; Bekar, Ozlem; Gürleyen, Büşra

2017-06-01

Literature has shown the importance of mentalizing techniques in symptom remission and emotional understanding; however, no study to date has looked at the dynamic relations between mental state talk and affect regulation in the psychotherapy process. From a psychodynamic perspective, the emergence of the child's capacity to regulate affect through the therapist's reflection on the child's mental states is a core aspect of treatment. In an empirical investigation of 2 single cases with separation anxiety disorder, who were treated in long-term psychodynamic play therapy informed with mentalization principles, the effect of therapists' and children's use of mental state talk on children's subsequent capacity to regulate affect in play was assessed. One case was a positive outcome case, whereas the other did not show symptomatic improvement at the end of treatment. Children's and therapists' utterances in the sessions were coded using the Coding System for Mental State Talk in Narratives, and children's play was coded by Children's Play Therapy Instrument, which generated an index of children's "affect regulation." Time-series Granger Causality tests showed that even though both therapists' use of mental state talk significantly predicted children's subsequent affect regulation, the association between child's mental state talk and affect regulation was only supported for the child who showed clinically significant symptom reduction. This study provided preliminary support that mental state talk in psychodynamic psychotherapy facilitates emotion regulation in play. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

A compromise too far: a review of Canadian cases of direct-to-consumer advertising regulation.

Science.gov (United States)

Lexchin, Joel; Mintzes, Barbara

2014-01-01

Since the mid 1990's, Canada has introduced partial direct-to-consumer advertising (DTCA) of prescription drugs through administrative policy shifts. Little documentation exists on how regulation occurs in practice. To evaluate Health Canada's response to complaints about DTCA. We use case studies about DTCA spanning from 2000 to 2011 to examine the stringency of regulation by Health Canada. The aim was to identify key themes in Health Canada's approach to regulation from a public health perspective. All of the material related to the cases was independently read by each of the authors and any disagreements in interpretation were resolved through discussion. We identified six weaknesses in how Health Canada deals with DTCA: failure to act on concerns about promotion for unapproved "off-label" uses, possible financial inducements to use a product, advertisements perceived to stimulate unwarranted fear about disease risks, and advertising of products with serious safety concerns identified in Health Canada safety advisories; ineffective enforcement actions undertaken by Health Canada; and lack of transparency in Health Canada's decision-making. There is an astonishing degree of discordance between public health priorities and regulation of DTCA in Canada. The current approach to enforcement is notable both for its lack of teeth and lack of accountability and transparency.

75 FR 41093 - General Services Administration Acquisition Regulation; Rewrite of GSAR Part 516, Types of Contracts

Science.gov (United States)

2010-07-15

...) will place all orders by EDI using computer-to-computer EDI. If computer-to-computer EDI is not possible, FAS will use an alternative EDI method allowing the Contractor to receive orders by facsimile transmission. Subject to the Contractor's agreement, other agencies may place orders by EDI. * * * * * (g) The...

75 FR 28771 - Federal Acquisition Regulation; FAR Case 2009-027, Personal Identity Verification of Contractor...

Science.gov (United States)

2010-05-24

... Acquisition Regulation; FAR Case 2009-027, Personal Identity Verification of Contractor Personnel AGENCIES... of collecting from contractors all forms of Government provided identification once they are no..., titled Controls Over the Contractor Common Access Card (CAC) Life Cycle, was performed to determine...

Neurofeedback, Affect Regulation and Attachment: A Case Study and Analysis of Anti-Social Personality

Science.gov (United States)

Fisher, Sebern F.

2007-01-01

This case study examines the effects of neurofeedback (EEG biofeedback) training on affect regulation in a fifty-five year-old man with a history marked by fear, rage, alcoholism, chronic unemployment and multiple failed treatments. He had been diagnosed with ADHD and attachment disorder and met criteria for anti-social personality disorder. The…

The effects of case-based team learning on students' learning, self regulation and self direction.

Science.gov (United States)

Rezaee, Rita; Mosalanejad, Leili

2015-01-26

The application of the best approaches to teach adults in medical education is important in the process of training learners to become and remain effective health care providers. This research aims at designing and integrating two approaches, namely team teaching and case study and tries to examine the consequences of these approaches on learning, self regulation and self direction of nursing students. This is a quasi experimental study of 40 students who were taking a course on mental health. The lessons were designed by using two educational techniques: short case based study and team based learning. Data gathering was based on two valid and reliable questionnaires: Self-Directed Readiness Scale (SDLRS) and the self-regulating questionnaire. Open ended questions were also designed for the evaluation of students' with points of view on educational methods. The Results showed an increase in the students' self directed learning based on their performance on the post-test. The results showed that the students' self-directed learning increased after the intervention. The mean difference before and after intervention self management was statistically significant (p=0.0001). Also, self-regulated learning increased with the mean difference after intervention (p=0.001). Other results suggested that case based team learning can have significant effects on increasing students' learning (p=0.003). This article may be of value to medical educators who wish to replace traditional learning with informal learning (student-centered-active learning), so as to enhance not only the students' knowledge, but also the advancement of long- life learning skills.

The Effects of Case-Based Team Learning on Students’ Learning, Self Regulation and Self Direction

Science.gov (United States)

Rezaee, Rita; Mosalanejad, Leili

2015-01-01

Introduction: The application of the best approaches to teach adults in medical education is important in the process of training learners to become and remain effective health care providers. This research aims at designing and integrating two approaches, namely team teaching and case study and tries to examine the consequences of these approaches on learning, self regulation and self direction of nursing students. Material & Methods: This is aquasi experimental study of 40 students who were taking a course on mental health. The lessons were designed by using two educational techniques: short case based study and team based learning. Data gathering was based on two valid and reliablequestionnaires: Self-Directed Readiness Scale (SDLRS) and the self-regulating questionnaire. Open ended questions were also designed for the evaluation of students’with points of view on educational methods. Results: The Results showed an increase in the students’ self directed learning based on their performance on the post-test. The results showed that the students’ self-directed learning increased after the intervention. The mean difference before and after intervention self management was statistically significant (p=0.0001). Also, self-regulated learning increased with the mean difference after intervention (p=0.001). Other results suggested that case based team learning can have significant effects on increasing students’ learning (p=0.003). Conclusion: This article may be of value to medical educators who wish to replace traditional learning with informal learning (student-centered-active learning), so as to enhance not only the students’ ’knowledge, but also the advancement of long- life learning skills. PMID:25946918

76 FR 38051 - Defense Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010...

Science.gov (United States)

2011-06-29

... Sexual Assault/Harassment Involving DoD Contractors During Contingency Operations,'' dated April 16, 2010... Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY... employees accompanying U.S. Armed Forces are made aware of the DoD definition of sexual assault as defined...

Eukaryotic Cell Cycle as a Test Case for Modeling Cellular Regulation in a Collaborative Problem-Solving Environment

Science.gov (United States)

2007-03-01

computer models of cell cycle regulation in a variety of organisms, including yeast cells, amphibian embryos, bacterial cells and human cells. These...and meiosis ), but they do not nullify the central role played by irreversible, alternating START and FINISH transitions in the cell cycle. 32...AFRL-IF-RS-TR-2007-69 Final Technical Report March 2007 EUKARYOTIC CELL CYCLE AS A TEST CASE FOR MODELING CELLULAR REGULATION IN A

75 FR 59103 - Defense Federal Acquisition Regulation Supplement; Motor Carrier Fuel Surcharge (DFARS Case 2008...

Science.gov (United States)

2010-09-27

...-AG30 Defense Federal Acquisition Regulation Supplement; Motor Carrier Fuel Surcharge (DFARS Case 2008... comments is provided below: 1. Comment. One respondent stated that it is customary in the motor carrier freight industry to assume a fixed cost of diesel fuel with a cost recovery mechanism (fuel surcharge) for...

75 FR 73997 - Defense Federal Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010...

Science.gov (United States)

2010-11-30

... Inspector General audit D-2010-052, entitled ``Efforts to Prevent Sexual Assault/Harassment Involving DoD... Acquisition Regulation Supplement; Definition of Sexual Assault (DFARS Case 2010-D023) AGENCY: Defense..., to ensure contractor employees are aware of the DoD definition of ``sexual assault'' as defined in Do...

Case note: ECJ (Case no. C-533/08, TNT Express Nederland BV. v. AXA Versicherung AG: The changing status of private international law treaties of the Member States in relation to regulation no. 44/2001)

NARCIS (Netherlands)

Kuijper, P.J.

2011-01-01

Case C-533/08, the so-called TNT case, is concerned with the interpretation of Article 71 of Regulation No. 44/2001 on jurisdiction and the recognition and enforcement of judgments in civil and commercial matters (hereinafter ‘Brussels Regulation’) and with the relation between this Regulation and

75 FR 13422 - Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer...

Science.gov (United States)

2010-03-19

...-AL26 Federal Acquisition Regulation; FAR Case 2008-015, Payments Under Fixed-Price Architect-Engineer..., Payments Under Fixed-Price Architect-Engineer Contracts, currently requires contracting officers to... judgment regarding the amount of payment withheld to apply under fixed-price architect-engineer (A-E...

Social cost-efficient service quality. Integrating customer valuation in incentive regulation. Evidence from the case of Norway

Energy Technology Data Exchange (ETDEWEB)

Growitsch, Christian; Mueller, Christine; Wissner, Matthias [WIK, Department Energy Markets and Energy Regulation, Rhoendorfer Str. 68, 53604 Bad Honnef (Germany); Jamasb, Tooraj [University of Cambridge, Faculty of Economics (United Kingdom)

2010-05-15

In order to overcome the perverse incentives of excessive maintenance reductions and insufficient network investments arising with incentive regulation of electricity distribution companies, regulators throughout Europe have started regulating service quality. In this paper, we explore the impact of incorporating customers' willingness-to-pay for service quality in benchmarking models on cost efficiency of distribution networks. Therefore, we examine the case of Norway, which features this approach to service quality regulation. We use the data envelopment analysis technique to analyse the effectiveness of such regulatory instruments. Moreover, we discuss the extent to which this indirect regulatory instrument motivates a socially desired service quality level. The results indicate that internalising external or social cost of service quality does not seem to have played an important role in improving cost efficiency in Norwegian distribution utilities. (author)

Social cost-efficient service quality-Integrating customer valuation in incentive regulation: Evidence from the case of Norway

Energy Technology Data Exchange (ETDEWEB)

Growitsch, Christian, E-mail: c.growitsch@wik.or [WIK, Department Energy Markets and Energy Regulation, Rhoendorfer Str. 68, 53604 Bad Honnef (Germany); Jamasb, Tooraj [University of Cambridge, Faculty of Economics (United Kingdom); Mueller, Christine; Wissner, Matthias [WIK, Department Energy Markets and Energy Regulation, Rhoendorfer Str. 68, 53604 Bad Honnef (Germany)

2010-05-15

In order to overcome the perverse incentives of excessive maintenance reductions and insufficient network investments arising with incentive regulation of electricity distribution companies, regulators throughout Europe have started regulating service quality. In this paper, we explore the impact of incorporating customers' willingness-to-pay for service quality in benchmarking models on cost efficiency of distribution networks. Therefore, we examine the case of Norway, which features this approach to service quality regulation. We use the data envelopment analysis technique to analyse the effectiveness of such regulatory instruments. Moreover, we discuss the extent to which this indirect regulatory instrument motivates a socially desired service quality level. The results indicate that internalising external or social cost of service quality does not seem to have played an important role in improving cost efficiency in Norwegian distribution utilities.

Social cost-efficient service quality-Integrating customer valuation in incentive regulation: Evidence from the case of Norway

International Nuclear Information System (INIS)

Growitsch, Christian; Jamasb, Tooraj; Mueller, Christine; Wissner, Matthias

2010-01-01

In order to overcome the perverse incentives of excessive maintenance reductions and insufficient network investments arising with incentive regulation of electricity distribution companies, regulators throughout Europe have started regulating service quality. In this paper, we explore the impact of incorporating customers' willingness-to-pay for service quality in benchmarking models on cost efficiency of distribution networks. Therefore, we examine the case of Norway, which features this approach to service quality regulation. We use the data envelopment analysis technique to analyse the effectiveness of such regulatory instruments. Moreover, we discuss the extent to which this indirect regulatory instrument motivates a socially desired service quality level. The results indicate that internalising external or social cost of service quality does not seem to have played an important role in improving cost efficiency in Norwegian distribution utilities.

Fostering Habib's Engagement and Self-Regulation: A Case Study of a Child from a Refugee Family at Home and Preschool

Science.gov (United States)

Haines, Shana J.; Summers, Jean Ann; Turnbull, Ann P.; Turnbull, H. Rutherford, III.; Palmer, Susan

2015-01-01

Developing children's self-regulation and engagement skills are primary goals of early childhood education. These skills are fostered in both home and preschool environments and can lead to improved educational outcomes. This qualitative case study investigated how a refugee family and Head Start teachers fostered the self-regulation and…

Biochemical interpretation of quantitative structure-activity relationships (QSAR) for biodegradation of N-heterocycles: a complementary approach to predict biodegradability.

Science.gov (United States)

Philipp, Bodo; Hoff, Malte; Germa, Florence; Schink, Bernhard; Beimborn, Dieter; Mersch-Sundermann, Volker

2007-02-15

Prediction of the biodegradability of organic compounds is an ecologically desirable and economically feasible tool for estimating the environmental fate of chemicals. We combined quantitative structure-activity relationships (QSAR) with the systematic collection of biochemical knowledge to establish rules for the prediction of aerobic biodegradation of N-heterocycles. Validated biodegradation data of 194 N-heterocyclic compounds were analyzed using the MULTICASE-method which delivered two QSAR models based on 17 activating (OSAR 1) and on 16 inactivating molecular fragments (GSAR 2), which were statistically significantly linked to efficient or poor biodegradability, respectively. The percentages of correct classifications were over 99% for both models, and cross-validation resulted in 67.9% (GSAR 1) and 70.4% (OSAR 2) correct predictions. Biochemical interpretation of the activating and inactivating characteristics of the molecular fragments delivered plausible mechanistic interpretations and enabled us to establish the following biodegradation rules: (1) Target sites for amidohydrolases and for cytochrome P450 monooxygenases enhance biodegradation of nonaromatic N-heterocycles. (2) Target sites for molybdenum hydroxylases enhance biodegradation of aromatic N-heterocycles. (3) Target sites for hydratation by an urocanase-like mechanism enhance biodegradation of imidazoles. Our complementary approach represents a feasible strategy for generating concrete rules for the prediction of biodegradability of organic compounds.

Epidemiological studies on Fasciola hepatica in Gafsa oases (South West of Tunisia

Directory of Open Access Journals (Sweden)

Hammami H.

2007-09-01

Full Text Available Epidemiological investigations on Fasciola hepatica fasciolasis were carried out from July 2004 to June 2005 in the Gafsa oases (Tunisia after the detection of a human case. Three habitats were studied: one in El Gsar and two in Ain Soltan. The prevalence of human infection was 6.6 %. The presence of the parasite was detected through serology in 14.3 % of cattle, 35 % of sheep and 68.4 % of goats. The plants Apium nodiflorum, Oxalis cernua and Sonchus maritimus were suspected to be at the origin of animal contamination and Apium nodiflorum was incriminated in human infection. The prevalence of the infection of the intermediate host Galba truncatula (G. truncatula was 19.2 % from July 2004 to June 2005. Gafsa oases constitute a new location for the development of fasciolasis in the southern west of Tunisia.

In search of better energy performance in the Portuguese buildings—The case of the Portuguese regulation

International Nuclear Information System (INIS)

Ferreira, Joaquim; Pinheiro, Manuel

2011-01-01

The Energy Performance of Buildings Directive (EPBD) is an important European policy tool to improve energy performance of buildings and has been applied in 27 countries with specific adjustments. The aim of this paper is to analyze the application of the Portuguese energy certification system and regulation to the residential sector using a case type, whilst considering a set of alternative and complementary solutions involving the regulation values for the envelope, interior and exterior thermal insulation, lower air renovation ratio, light colored exterior walls, better glazing system, shading elements and a Trombe Wall. In order to understand the role and the importance of bioclimatic measures in the Portuguese application of the EPBD, a comparison with the Passivhaus Norm applied to warm countries in Europe will be made. Due to the diversity of the Portuguese climate, three different climate regions were considered. Finally, we will discuss what new measures should be added to the Portuguese regulation, so that the proposed recast of the Directive might be transformed into a more effective tool in the search for better energy performance, passive house buildings and sustainable constructions. - Highlights: ► We have analyzed the Portuguese residential application of the EPBD. ► The analysis was based on a case-study building located in 3 climatic zones. ► We conducted a comparative study between the RCCTE demands and the Passivhaus ones. ► The energy demand was improved, introducing different measures by climatic zone. ► To improve buildings performance, the Regulation should consider more passive demands.

77 FR 76939 - Defense Federal Acquisition Regulation Supplement: Definition of Cost or Pricing Data (DFARS Case...

Science.gov (United States)

2012-12-31

... cost or pricing data'' in its place. PART 217--SPECIAL CONTRACTING METHODS 217.7401 [Amended] 0 11... Cost or Pricing Data (DFARS Case 2011-D040) AGENCY: Defense Acquisition Regulations System, Department... ``certified cost or pricing data'' and ``data other than certified cost or pricing data.'' The DFARS changes...

75 FR 71563 - Defense Federal Acquisition Regulation Supplement; Services of Senior Mentors (DFARS Case 2010-D025)

Science.gov (United States)

2010-11-24

... mentoring, teaching, training, advice, and recommendations to senior military officers, staff, and students... Acquisition Regulation Supplement; Services of Senior Mentors (DFARS Case 2010-D025) AGENCY: Defense... policy on the services of senior mentors. DATES: Effective: November 24, 2010. FOR FURTHER INFORMATION...

Exploring Self-Regulation through a Reflective Practicum: A Case Study of Improvement through Mindful Piano Practice

Science.gov (United States)

Pike, Pamela D.

2017-01-01

Learning to self-regulate during practice is one of the most important skills that music majors must learn. Yet, because practising tends to occur mostly in private, there can be a disconnect between instructors' approaches to teaching practice skills in the lesson and students' actual behaviour in the practice room. This case study explored the…

Examining the Correspondence between Self-Regulated Learning and Academic Achievement: A Case Study Analysis

Directory of Open Access Journals (Sweden)

Timothy J. Cleary

2013-01-01

Full Text Available Four high school students received 11 weeks of a self-regulated learning (SRL intervention, called the Self-Regulation Empowerment Program (SREP, to improve their classroom-based biology exam scores, SRL, and motivated behaviors. This mixed model case study examined the correspondence between shifts in students’ strategic, regulated behaviors with their performance on classroom-based biology tests. The authors used traditional SRL assessment tools in a pretest-posttest fashion (e.g., self-report questionnaires, teaching rating scales and gathered SRL data during the intervention using field note observations and contextualized structured interviews. This multidimensional assessment approach was used to establish convergence among the assessment tools and to facilitate interpretation of trends in students’ biology test performance relative to their SRL processes. Key themes in this study included the following: (a the close correspondence between changes in students SRL, biology exam performance, and SREP attendance; (b individual variability in student performance, SRL behaviors, and beliefs in response to SREP; and (c the importance of using a multi-dimensional assessment approach in SRL intervention research. Furthermore, this study provided additional support for the potential effectiveness of SREP in academic contexts.

75 FR 13421 - Federal Acquisition Regulation; FAR Case 2008-036, Trade Agreements-Costa Rica, Oman, and Peru

Science.gov (United States)

2010-03-19

... 9000-AL23 Federal Acquisition Regulation; FAR Case 2008-036, Trade Agreements--Costa Rica, Oman, and... United States-Oman Free Trade Agreement, and the United States-Peru Trade Promotion Agreement. DATES... interim rule. The interim rule added Costa Rica, Oman, and Peru to the definition of ``Free Trade...

Assessing the accuracy of a simplified building energy simulation model using BESTEST : the case study of Brazilian regulation

NARCIS (Netherlands)

Melo, A.P.; Cóstola, D.; Lamberts, R.; Hensen, J.L.M.

2012-01-01

This paper reports the use of an internationally recognized validation and diagnostics procedure to test the fidelity of a simplified calculation method. The case study is the simplified model for calculation of energy performance of building envelopes, introduced by the Brazilian regulation for

Collaborative planning in natural resource management – the case of regulation of nitrogen in the agri-environment

DEFF Research Database (Denmark)

Vejre, Henrik; Andersen, Erling; Andersen, Peter Stubkjær

approach is that local knowledge on, e.g. farming practices, soil, water and climate, can feed into the regulation process, making general rules less important, maybe even obsolete. Methods: The planning approach adapted for the study was inspired by concepts of collaborative planning in urban areas...... approaches are gaining momentum. The aim of this paper is to test a collaborative planning approach in the regulation of nitrogen in the farming sector. The overarching question is whether this regulation can be organised locally rather than by general, national rules. The benefits by adopting a local...... and various other concepts of participatory environmental planning. The approach was tested simultaneously in six case areas of rural Denmark, each comprising small watersheds (20-76km2). The strategic aim was to reduce the loss of nitrogen from farms to the aquatic environment. The planning process consisted...

The TEXTBOOK - Directives, Regulations, Case Law

DEFF Research Database (Denmark)

Fomcenco, Alex; Werlauff, Erik

The TEXTBOOK is a collection of carefully selected directives, regulations, and judgments. Whether you are a student, a scholar, or a practitioner of law, this book is a supplemental tool in your work with European business law. It is recommended that you have this book within your reach when you...

The Italian regulation on Assisted Reproductive Technologies facing the European Court of Human Rights: the case of Costa and Pavan v. Italy.

Science.gov (United States)

Penasa, Simone

2012-01-01

This article will describe the current legal framework on Assisted Reproduction Technology (ART) regulation in Italy, taking into account recent case-law derived from the implementation of the Law 40 of 2004 on ART. Special attention will be devoted to the case of Costa and Pavan v. Italy, recently decided by the Tenth Session of the European Court of Human Rights (ECtHR). In that decision, the European Court declared the incompatibility of the ban to pre-implantation genetic diagnosis introduced by the abovementioned Italian law on ART. The case will be analysed from a dual perspective. On the one hand, it will be considered in the light of the ECtHR case-law, in order to derive systematic aspects of continuity or discontinuity between the former and the latter2. On the other hand, the case will be considered in the light of its concrete and prospective impact on the Italian legal approach to ART regulation, considering especially the direct and indirect influence of the case: e.g., its possible utilisation by Italian judges when they are called upon to implement Law 40.

De-regulated electric power markets and operating nuclear power plants: the case of British energy

International Nuclear Information System (INIS)

Hewlett, James G.

2005-01-01

One issue addressed in almost all electric power restructuring/de-regulation plans in both the United States (US) and the United Kingdom (UK) was the recovery of operating nuclear power plant's spent fuel disposal costs and the expenditures to decommission the units when they are retired. Prior to restructuring, in theory at least, in both countries, electricity consumers were paying for the back end costs from operating nuclear power plants. Moreover, in virtually all cases in the US, states included special provisions to insure that consumers would continue to do so after power markets were de-regulated. When power markets in the UK were initially restructured/de-regulated and nuclear power privatized, the shareholders of British Energy (BE) were initially responsible for these costs. However, after electricity prices fell and BE collapsed, the British government shifted many of the costs to future taxpayers, as much as a century forward. If this was not done, the book value of BE's equity would have been about -3.5 billion pounds. That is, BE's liabilities would have been about -3.5 billion pounds greater than their assets. It is difficult to see how BE could remain viable under such circumstances

The Organization and Regulation of Full Contact Martial Arts: A Case Study of Flanders

Directory of Open Access Journals (Sweden)

Jikkemien Vertonghen

2014-11-01

Full Text Available To date, martial arts involvement is often described in controversial terms. While some studies report increased anti-social behavior as a result of martial arts involvement, other findings refer to a more positive social and personal development. This paradox has resulted in an ambiguous public discourse on their value and legitimacy as socially accepted sports, often leading to a dichotomization between “good” and “bad” styles of martial arts. Up until now however, there has been a lack of empirical proof that this “good versus bad” perspective divides along the lines of specific martial arts styles. Consequently, the distinct moral and medical concerns regarding the effects of involvement in harder martial arts—combined with their increased popularity, as well as their perceived positive outcomes for specific target groups—have resulted in a growing demand among policy makers to develop (or rethink their strategy towards the regulation and support of these sports. By means of a case-study approach, the present paper discusses some of the key issues regarding the regulation of a number of full contact martial arts (e.g., kickboxing, Muay Thai, MMA, which are considered to be problematic for (sport authorities, and which confront sports policy makers in Flanders. In describing the Flemish case, this paper aims to highlight the need to develop a sound martial arts policy that can provide a legitimation base for the provision and organization of full contact martial arts, which have become increasingly popular in recent years.

Emergency Response Program Designing Based On Case Study ERP Regulations In Ilam Gas Refinery

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Mehdi Tahmasbi

2015-08-01

Full Text Available The study of Emergency response plan designing is one of the most important prevention approaches in crisis management. This study aims to design emergency response plan based on case study ERP regulations in Ilam gas refinery. On the basis of risk assessment and identification techniques such as HAZOP and FMEA in Ilam gas refinery the risks have been prioritized and then according to this prioritization the design of possible scenarios which have the highest rate of occurrence and the highest level of damage has been separated. Possible scenarios were simulated with PHAST software. Then emergency response program has been designed for the special mode or similar cases. According to the internal emergency response plan for Ilam gas refinery and predictable conditions of the process special instructions should be considered at the time of the incident to suffer the least damage on people and environment in the shortest time possible.

Developments on ASME Code Cases to Risk-Informed Repair/Replacement Activities in Support of Risk-Informed Regulation Initiatives

International Nuclear Information System (INIS)

Balkey, Kenneth R.; Holston, William C.

2002-01-01

ASME Code Case N-658, 'Risk-Informed Safety Classification for Use in Risk-Informed Repair/Replacement Activities' and Code Case N-660, 'Alternative Repair/Replacement Requirements For Items Classified In Accordance With Risk-Informed Processes' are being completed to expand the breadth of risk-informed requirements for pressure-retaining items. This initiative, which is built from prior ASME Section XI risk-informed inservice inspection developments over the past decade, has been undertaken in conjunction with U.S. risk-informed regulation efforts. The U.S. Nuclear Regulatory Commission (NRC) is working with the industry on risk informing Title 10 Code of Federal Regulations Part 50 (10CFR50). The Nuclear Regulatory Commission's basic proposal is to allow modification of some of the special treatment requirements of 10CFR50. Their effort is proceeding via an Advanced Notice of Public Rulemaking, March 3, 2000, and an announcement of Availability of Draft Rule Wording, November 29, 2001, to add 10 CFR 50.69, 'Risk-Informed Treatment of Structures, Systems and Components'. A parallel task by the Nuclear Energy Institute (NEI) to develop a guideline on how to implement the results of the rulemaking is also well underway via NEI 00-04 (Draft Revision B), 'Option 2 Implementation Guideline', May 2001. This paper summarizes the content and status of approval of the proposed ASME Code Cases, including how they relate to the above NRC and NEI efforts. Some initial results from trial application of the Code Cases will also be cited. (authors)

Supporting Affect Regulation in Children With Multiple Disabilities During Psychotherapy: A Multiple Case Design Study of Therapeutic Attachment. [Miscellaneous Article

NARCIS (Netherlands)

Schuengel, C; Sterkenburg, P S; Jeczynski, P; Janssen, C G C; Jongbloed, G

2009-01-01

: In a controlled multiple case design study, the development of a therapeutic relationship and its role in affect regulation were studied in 6 children with visual disabilities, severe intellectual disabilities, severe challenging behavior, and prolonged social deprivation. In the 1st phase,

Phosphorylation Regulates the Bound Structure of an Intrinsically Disordered Protein: The p53-TAZ2 Case.

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Raúl Esteban Ithuralde

Full Text Available Disordered regions and Intrinsically Disordered Proteins (IDPs are involved in critical cellular processes and may acquire a stable three-dimensional structure only upon binding to their partners. IDPs may follow a folding-after-binding process, known as induced folding, or a folding-before-binding process, known as conformational selection. The transcription factor p53 is involved in the regulation of cellular events that arise upon stress or DNA damage. The p53 domain structure is composed of an N-terminal transactivation domain (p53TAD, a DNA Binding Domain and a tetramerization domain. The activity of TAD is tightly regulated by interactions with cofactors, inhibitors and phosphorylation. To initiate transcription, p53TAD binds to the TAZ2 domain of CBP, a co-transcription factor, and undergoes a folding and binding process, as revealed by the recent NMR structure of the complex. The activity of p53 is regulated by phosphorylation at multiple sites on the TAD domain and recent studies have shown that modifications at three residues affect the binding towards TAZ2. However, we still do not know how these phosphorylations affect the structure of the bound state and, therefore, how they regulate the p53 function. In this work, we have used computational simulations to understand how phosphorylation affects the structure of the p53TAD:TAZ2 complex and regulates the recognition mechanism. Phosphorylation has been proposed to enhance binding by direct interaction with the folded protein or by changing the unbound conformation of IDPs, for example by pre-folding the protein favoring the recognition mechanism. Here, we show an interesting turn in the p53 case: phosphorylation mainly affects the bound structure of p53TAD, highlighting the complexity of IDP protein-protein interactions. Our results are in agreement with previous experimental studies, allowing a clear picture of how p53 is regulated by phosphorylation and giving new insights into how

Danish Working Environment Regulation. How reflexive - how political? -a Scandinavian case

DEFF Research Database (Denmark)

Koch, Christian

an understanding of the directions of the reforms made in this period. The paper operate with two analytical perspectives: The reflexive regulation perspective and the political process perspective. Danish working environment regulation is discussed through the general political initiatives taken, and through four...... specific regulation topics: The Occupational Health Services (OHS), regulation of the psychological working environment, the 'Monotonous Repeated Work'-plan and the workers' compensation. Taking the last twenty years' development as a whole the main developments in the regulation is a further shift...... in balance between material and reflexive regulation elements to the benefit of the latter. But although the reflexive elements seem to stabilize, they are vulnerable to a loss of legitimacy and changes in the political pattern.The impact on enterprise power patterns is summed up in a polarization thesis...

Education versus regulation: The case for regulating the indoor tanning industry.

Science.gov (United States)

Benet, Suzeanne; Kraft, Frederic

2016-05-01

We examine marketing strategies for indoor tanning services that often target young adult females. Evidence of the addictive nature of indoor tanning suggests that young adults may be vulnerable to the promotion of indoor tanning and as a result deserve greater protection from the marketing of these services. As public awareness of the rising numbers of skin cancers linked to indoor tanning grows, we believe that the public will support increased regulation of this industry.

Transportation of radioactive materials. Safety and regulation

International Nuclear Information System (INIS)

Niel, Jean-Christophe

2013-01-01

This engineering-oriented publication first presents fluxes and risks related to the transportation of radioactive materials: fluxes, risks, in-depth defence, and parcel typology. The author then describes the elaboration process for transportation regulations: IAEA recommendations for the transportation of radioactive materials and their review process, IAEA recommendations for modal regulations. He presents the French transportation regulation framework: evolutions of IAEA recommendations, case of aerial transport, and case of maritime transport. The next part addresses the specific case of the transportation of uranium hexafluoride. The last part addresses incidents and accidents occurring during transportation: declarations to be made, brief presentations of several examples of incidents and accidents

Risk, regulation and biotechnology: the case of GM crops.

Science.gov (United States)

Smyth, Stuart J; Phillips, Peter W B

2014-07-03

The global regulation of products of biotechnology is increasingly divided. Regulatory decisions for genetically modified (GM) crops in North America are predictable and efficient, with numerous countries in Latin and South America, Australia and Asia following this lead. While it might have been possible to argue that Europe's regulations were at one time based on real concerns about minimizing risks and ensuring health and safety, it is increasingly apparent that the entire European Union (EU) regulatory system for GM crops and foods is now driven by political agendas. Countries within the EU are at odds with each other as some have commercial production of GM crops, while others refuse to even develop regulations that could provide for the commercial release of GM crops. This divide in regulatory decision-making is affecting international grain trade, creating challenges for feeding an increasing global population.

Cash Flow Valuation in an Inflactionary World. The Case of World Bank for Regulated Firms

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Ignacio Vélez-Pareja

2007-11-01

Full Text Available We show that project evaluation should be based on free cash flows at nominal prices. We present a case where the results from the constant price method are biased upwards and there is a risk to accept bad projects. It is a widespread practice to evaluate projects at constant prices. With an example presented in the training on economic regulation of public utilities developed by the World Bank Institute we asses that methodology. We show an overvaluation of 21% when compared with the current prices methodology and using a correct Weighted Average Cost of Capital, WACC.

Application of the ELOHA Framework to Regulated Rivers in the Upper Tennessee River Basin: A Case Study

Energy Technology Data Exchange (ETDEWEB)

McManamay, Ryan A [ORNL; Orth, Dr. Donald J [Virginia Polytechnic Institute and State University (Virginia Tech); Dolloff, Dr. Charles A [USDA Forest Service, Department of Fisheries and Wildlife Sciences, Virginia Tech; Mathews, David C [Tennessee Valley Authority (TVA)

2013-01-01

In order for habitat restoration in regulated rivers to be effective at large scales, broadly applicable frameworks are needed that provide measurable objectives and contexts for management. The Ecological Limits of Hydrologic Alteration (ELOHA) framework was created as a template to assess hydrologic alterations, develop relationships between altered streamflow and ecology, and establish environmental flow standards. We tested the utility of ELOHA in informing flow restoration applications for fish and riparian communities in regulated rivers in the Upper Tennessee River Basin (UTRB). We followed the steps of ELOHA to generate flow alteration-ecological response relationships and then determined whether those relationships could predict fish and riparian responses to flow restoration in the Cheoah River, a regulated system within the UTRB. Although ELOHA provided a robust template to construct hydrologic information and predict hydrology for ungaged locations, our results do not support the assertion that over-generalized univariate relationships between flow and ecology can produce results sufficient to guide management in regulated rivers. After constructing multivariate models, we successfully developed predictive relationships between flow alterations and fish/riparian responses. In accordance with model predictions, riparian encroachment displayed consistent decreases with increases in flow magnitude in the Cheoah River; however, fish richness did not increase as predicted four years post- restoration. Our results suggest that altered temperature and substrate and the current disturbance regime may have reduced opportunities for fish species colonization. Our case study highlights the need for interdisciplinary science in defining environmental flows for regulated rivers and the need for adaptive management approaches once flows are restored.

REGULATION OF AUSTRALIAN MEDICAL PROFESSIONALS AND NATIONAL SECURITY: LESSONS FROM THREE CASE STUDIES.

Science.gov (United States)

Faunce, Thomas; McKenna, Michael; Rayner, Johanna; Hawes, Jazmin

2016-03-01

In recent times, Australia's national security concerns have had controversial impacts on regulation of Australian medical practitioners in areas related to immigration detention. This column explores three recent case studies relevant to this issue. The first involves the enactment of the Australian Border Force Act 2015 (Cth), which has a significant impact on the regulation of medical professionals who work with people in immigration detention. The second involves the decision of the High Court of Australia in Plaintiff M68/2015 v Minister for Immigration and Border Protection [2016] HCA 1 that an amendment to Australian federal legislation justified sending children back to immigration detention centres in Papua New Guinea and Nauru. This legislation was previously heavily criticised by the Australian Human Rights Commissioner. The third concerns the deregistration of Tareq Kamleh, an Australian doctor of German-Palestinian heritage who came to public attention on ANZAC Day 2015 with his appearance online in a propaganda video for the Islamic State terrorist organisation al-Dawla al-Islamyia fil Iraq wa'al Sham, also known as Islamic State of Iraq and Syria (ISIS) or Daesh. Australia's professional regulatory system should presumptively respect professional virtues, such as loyalty to the relief of individual patient suffering, when dealing with doctors (whether in Australia or ISIS-occupied Syria) working under regimes whose principles appear inconsistent with those of ethics and human rights.

Regulations relevant to the transport of radioactive materials in Switzerland

International Nuclear Information System (INIS)

Smith, L.

1996-01-01

As is the case in many countries, the transport of radioactive materials in Switzerland is primarily regulated by the national regulations for the transport of dangerous goods. Currently these regulations, in the case of radioactive material, incorporate the 1985 IAEA Safety Series 6 Regulations for the Safe Transport of Radioactive Material (As amended 1990). However, as is also the case in some other countries, consignors, shippers and carriers of radioactive materials must also comply with additional laws when shipping radioactive materials. The most important of these other laws and their accompanying regulations are those concerned with radiation protection (import, export and carriers licences) and nuclear power (import, export, inland transport and transit licences). This paper sets out to describe the collective requirements resulting from all three of these sets of regulations. (Author)

24th WRSM panel discussion: open-quotes The role of research in nuclear regulation: The case of qualified importersclose quotes

International Nuclear Information System (INIS)

Alonso, A.

1997-01-01

Scientific knowledge and technological maturity are needed to establish regulatory requirements, what also needs talent and skills. Scientists are rarely interested in regulation and regulators not always are closely connected to scientific research. This has created gaps in regulations, mainly within qualified importers. A qualified importer, in the sense of this presentation, is a country who has acquired nuclear power plants from more technologically advanced exporters but with an increasing participation of its own industry and institutions in the design, construction, component manufacture and assembly of such nuclear power plants and is fully responsible for the operation of the nuclear units and the corresponding fuel cycle. These countries have also a long standing and independent nuclear regulatory organization and the corresponding technical body. Spain is a qualified importer. In the case of Spain, it originally adopted the codes and regulations of the UE which it was a member of, as well as the codes and standards of the country from which their reactors were produced. Since Spain added KWU plants they even went to German regulations. Plant operation rested with Spain. As problems began to appear in operating plants, local research projects were funded to study the problems, aimed at immediate solutions, but also providing training for local personnel in addition to information of use for regulators. Spain has participated in many joint research projects, which have trained people, and given confidence to Spaniards involved in science and regulations. Qualified importers, like Spain, participate in research, even though it may not translate itself into regulation. Such participation will always serve to give self-confidence and independence to regulators and licensees, to better understand the adopted regulations of the most advanced countries and to solve specific problems

Regulation Strategy in Natural Gas Sector. The Romanian Case

Directory of Open Access Journals (Sweden)

Coralia Angelescu

2006-10-01

Full Text Available This study provides a methodological analysis to evaluate the regulation strategy in Romanian natural gas sector. The market oriented reforms are not only associated with the gap between internal prices and world prices. In the same time, the market oriented reforms are mixed with the other forms of government intervention. The industry network theory provides a good pillar for maintaining natural monopoly in public utilities. The conclusions which are presented in this article offer a good theory for the activity of the National Authority of Regulation in Romanian natural gas sector.

EMERGING COMMON LAW DECISIONS IN GOODWILL ACCOUNTING REGULATION

OpenAIRE

Radu-Daniel LOGHIN

2014-01-01

In respect to financial reporting, statutory accounting standards and regulations form only a part of the normative landscape. Considering the case of common law countries, besides these classic sources of norms and practices there is an alternative base for exercising the professional judgement of the accountant, the case law precedents which drive and supplement in cases accounting regulations. For the purpose of this paper, goodwill accounting is explored from a normative perspective which...

Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway

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La Torre Agostino

2010-09-01

Full Text Available Abstract Background Treatment strategies for Retinoblastoma (RB, the most common primary intraocular tumor in children, have evolved over the past few decades and chemoreduction is currently the most popular treatment strategy. Despite success, systemic chemotherapeutic treatment has relevant toxicity, especially in the pediatric population. Antiangiogenic therapy has thus been proposed as a valuable alternative for pediatric malignancies, in particolar RB. Indeed, it has been shown that vessel density correlates with both local invasive growth and presence of metastases in RB, suggesting that angiogenesis could play a pivotal role for both local and systemic invasive growth in RB. We present here two cases of sporadic, bilateral RB that did not benefit from the conservative treatment and we provide evidence that the VEGF-A pathway is significantly up-regulated in both RB cases along with an over expression of hERG1 K+ channels. Case presentation Two patients showed a sporadic, bilateral RB, classified at Stage II of the Reese-Elsworth Classification. Neither of them got benefits from conservative treatment, and the two eyes were enucleated. In samples from both RB cases we studied the VEGF-A pathway: VEGF-A showed high levels in the vitreous, the vegf-a, flt-1, kdr, and hif1-α transcripts were over-expressed. Moreover, both the transcripts and proteins of the hERG1 K+ channels turned out to be up-regulated in the two RB cases compared to the non cancerous retinal tissue. Conclusions We provide evidence that the VEGF-A pathway is up-regulated in two particular aggressive cases of bilateral RB, which did not experience any benefit from conservative treatment, showing the overexpression of the vegf-a, flt-1, kdr and hif1-α transcripts and the high secretion of VEGF-A. Moreover we also show for the first time that the herg1 gene transcripts and protein are over expressed in RB, as occurs in several aggressive tumors. These results further stress

Contract & agency labour: beyond self-regulation?

OpenAIRE

Cotton, Elizabeth

2010-01-01

A paper about the regulation of contract labour. Academic and legal aspects as well as case studies of global union federation work to organise and regulate contract labour in Thailand, Pakistan, Colombia, South Korea and at international level.

76 FR 6381 - Fee-Generating Cases

Science.gov (United States)

2011-02-04

... LEGAL SERVICES CORPORATION 45 CFR Part 1609 Fee-Generating Cases AGENCY: Legal Services...) proposes to amend the Legal Services Corporation's regulation on fee-generating cases to clarify that it... intended. LSC's regulation at 45 CFR part 1609, Fee- Generating Cases, is based on Sec. 1007(b)(1) of the...

Intrathoracic pressure regulation during cardiopulmonary resuscitation: a feasibility case-series.

Science.gov (United States)

Segal, Nicolas; Parquette, Brent; Ziehr, Jonathon; Yannopoulos, Demetris; Lindstrom, David

2013-04-01

Intrathoracic pressure regulation (IPR) is a novel, noninvasive therapy intended to increase cardiac output and blood pressure in hypotensive states by generating a negative end expiratory pressure of -12 cm H2O between positive pressure ventilations. In this first feasibility case-series, we tested the hypothesis that IPR improves End tidal (ET) CO2 during cardiopulmonary resuscitation (CPR). ETCO2 was used as a surrogate measure for circulation. All patients were treated initially with manual CPR and an impedance threshold device (ITD). When IPR-trained medics arrived on scene the ITD was removed and an IPR device (CirQLATOR™) was attached to the patient's advanced airway (intervention group). The IPR device lowered airway pressures to -9 mmHg after each positive pressure ventilation for the duration of the expiratory phase. ETCO2, was measured using a capnometer incorporated into the defibrillator system (LifePak™). Values are expressed as mean ± SEM. Results were compared using paired and unpaired Student's t test. p values of <0.05 were considered statistically significant. ETCO2 values in 11 patients in the case series were compared pre and during IPR therapy and also compared to 74 patients in the control group not treated with the new IPR device. ETCO2 values increased from an average of 21 ± 1 mmHg immediately before IPR application to an average value of 32 ± 5 mmHg and to a maximum value of 45 ± 5mmHg during IPR treatment (p<0.001). In the control group ETCO2 values did not change significantly. Return of spontaneous circulation (ROSC) rates were 46% (34/74) with standard CPR and ITD versus 73% (8/11) with standard CPR and the IPR device (p<0.001). ETCO2 levels and ROSC rates were significantly higher in the study intervention group. These findings demonstrate that during CPR circulation may be significantly augmented by generation of a negative end expiratory pressure between each breath. Copyright © 2012 Elsevier Ireland Ltd. All rights

Management of linear quadratic regulator optimal control with full-vehicle control case study

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Rodrigue Tchamna

2016-09-01

Full Text Available Linear quadratic regulator is a powerful technique for dealing with the control design of any linear and nonlinear system after linearization of the system around an operating point. For small systems, which have fewer state variables, the transformation of the performance index from scalar to matrix form can be straightforward. On the other hand, as the system becomes large with many state variables and controllers, appropriate design and notations should be defined to make it easy to automatically implement the technique for any large system without the need to redesign from scratch every time one requires a new system. The main aim of this article was to deal with this issue. This article shows how to automatically obtain the matrix form of the performance index matrices from the scalar version of the performance index. Control of a full-vehicle in cornering was taken as a case study in this article.

Connection, regulation, and care plan innovation: a case study of four nursing homes.

Science.gov (United States)

Colón-Emeric, Cathleen S; Lekan-Rutledge, Deborah; Utley-Smith, Queen; Ammarell, Natalie; Bailey, Donald; Piven, Mary L; Corazzini, Kirsten; Anderson, Ruth A

2006-01-01

We describe how connections among nursing home staff impact the care planning process using a complexity science framework. We completed six-month case studies of four nursing homes. Field observations (n = 274), shadowing encounters (n = 69), and in-depth interviews (n = 122) of 390 staff at all levels were conducted. Qualitative analysis produced a conceptual/thematic description and complexity science concepts were used to produce conceptual insights. We observed that greater levels of staff connection were associated with higher care plan specificity and innovation. Connection of the frontline nursing staff was crucial for (1) implementation of the formal care plan and (2) spontaneous informal care planning responsive to changing resident needs. Although regulations could theoretically improve cognitive diversity and information flow in care planning, we observed instances of regulatory oversight resulting in less specific care plans and abandonment of an effective care planning process. Interventions which improve staff connectedness may improve resident outcomes.

A New Context Affording for Regulation: The Case of Musical Play

Science.gov (United States)

Zachariou, Antonia; Whitebread, David

2017-01-01

The present study set out to investigate theoretical speculations that regulation and musical play, an initial manifestation of musicality, are directly linked. This study aimed to explore the potential for regulation to occur during musical play and investigate the nature of the regulatory behaviours. Thirty-six children, aged 6 and 8, were…

THE ANALYSE OF THE REGULATIONS AT THE EUROPEAN LEVEL REGARDING CARTELS. CASE SUDY: CARTEL BETWEEN THE COMPANIES CHIQUITA AND PACIFIC

Directory of Open Access Journals (Sweden)

Berinde Mihai

2012-07-01

Full Text Available The present paper tries to make an analyse of the policy in the field of competition, at the level of the European Union, more exactly the policy applied on cartels. It is important to know the regulations regarding cartels, especially the way in which procedures are done in the case of a cartel. Cartels have a negative impact on competition and consumers, and that’s why it is extremely important that they are discovered on time and after that, by using correction measures to try to recuperate the created damage. The used research method is the analyze of the legislation in force regarding cartels and the study of the existing literature in this field, and in order to give an example of the procedures in the case of a cartel, we analyzed the cartel between two companies Chiquita and Pacific. It is extremely important for these regulations to be known, and in order to discourage such practices, the European Committee has thought of a series of advantages for the companies that give information and evidence regarding the existence of a cartel. Among these advantages we could mention immunity to fine, that permits the company to be absolved of all its fines. The paper presents schematically the legislation that forbids anti-competitive practices, at the level of the European Union, and after that the applied procedure when a law violation is discovered. The modality in which the procedures are applied, in the case of suspecting a cartel, have been presented step by step, and after that, the case study does not exist only to give an example of procedures, but also to present the applied methods, in the case of success in proving the existence of a cartel. The importance of competition policy at a European level cannot be denied because of the fact that only by implementing of a proper policy in this field, an economy can develop further.

Case study of the effects of public safety regulation on the construction costs of coal-fired and nuclear power plants

International Nuclear Information System (INIS)

Morris, C.D.

1987-01-01

Regulations intended to reduce the number of accidents at nuclear plants and the discharge of sulfur and particulate wastes at coal-fired power plants have become an important cause of construction cost escalation. Measuring the costs of these regulatory interventions is a difficult research task. The three-unit Bruce Mansfield coal-fired plant and the two-unit Beaver Valley nuclear power station located in Shippingport, Pennsylvania, provide a unique opportunity for a case study of the costs of regulation in the construction of both kinds of plants. The units of each plant were built sequentially over a period of intensifying regulation. The method used to measure the costs of public safety regulation in the construction of each kind of plant is to determine the connections between the issuances of the regulatory agencies (EPA and NRC) and cost escalations of succeeding units. The small cost escalations of the Mansfield 3 unit, in comparison to the massive costs of the Beaver Valley 2 unit, suggest that the design and construction of new coal-fired plants are not disrupted by regulatory interventions nearly as extensively as are nuclear units. Certain technical features of Beaver Valley 2, especially its small size and a design that is identical to the first unit's, further contribute to its cost escalations

The regulation of social education as a profession: an analysis of the processes of regulation of the identity and socio-professional status of the social educator in Portugal and Brazil

Directory of Open Access Journals (Sweden)

Henrique Pereira Ramalho

2017-07-01

Full Text Available This article deals with the processes of regulation of the exercise of social education as a profession that we consider as emergent (in the portuguese case and diffuse (in the brazilian case. In the first case, we look at an institutional logic of the profession, in which self-regulation processes are more prevalent, although they resort to petitioning procedures through which, and in a subsidiary way, they seek to "fit in" the profession of social educator in the "world” of the segmented professions according to the portuguese norm. In the case of the Brazilian context, a process of regulation that bets on the legitimating preponderance of the State, As a regulatory agency of the regulation of the profession, even though self-regulatory procedures are subsidiarily recognized, without calling into question the medial role of the State as the main regulator. Keywords: regulation; social education; social educator; emergent profession; diffuse profession

Impact of Environmental Regulation on Productivity: Case Studies of Three Industries in Japan

OpenAIRE

Chalermthanakom, Adisak; Ueta, Kazuhiro

2011-01-01

Although fi rms bear the cost of compliance, strict but fl exible environmental regulation may benefi t them by spurring the innovation process. However, the relationship between environmental regulation and productivity is unclear. We calculate productivity growth by using data envelopment analysis; we then conduct regression analysis, using panel data on productivity growth by environmental regulation stringency. A one-year lag of environmental regulation stringency is included in the model...

Using therapeutic jurisprudence and preventive law to examine disputants' best interests in mediating cases about physicians' practices: a guide for medical regulators.

Science.gov (United States)

Ferris, Lorraine E

2004-01-01

Therapeutic jurisprudence (TJ) and preventive law (PL) are used as two theoretical perspectives from which to examine the best interests of parties in mediation because of a dispute about a physician's practice. The focus is mediation provided by and/or for the medical regulator. The paper reviews the literature on TJ and PL, and their relationship to mediation, and demonstrates how medical regulators could benefit by working within a framework reflecting both these perspectives providing it does not involve an egregious matter. A TJ and PL framework would be of particular value in identifying cases for mediation and in evaluating resolutions to mediated disputes.

Regulations and instructions for RA reactor operation

International Nuclear Information System (INIS)

1989-01-01

This regulatory guide consists of following 4 chapters: Description of the RA reactor, organization scheme, regulations for performing experiments; Regulations for staff on duty; Instructions for operating the vacuum systems, heavy water and helium systems; and evacuation in case of accident [sr

Regulation on control systems tests

International Nuclear Information System (INIS)

Grau, J.; Navarro, J.M.

1978-01-01

Requirements under regulation applicable to the testing of control systems and controlled equipments in the case of USA nuclear projects are examined. They are reviewed, in particular, the following standards and criteria: 10 Code of Federal Regulations 50, Appendix A, General Design Criteria 20 and 21; IEEE Standards 279 and 308; IEEE Standard 338; US Regulatory Guides 1.22 and 1.118.(J.E.de C.)

Externality-correcting taxes and regulation

OpenAIRE

Christiansen, V.; Smith, S.

2009-01-01

Much of the literature on externalities has considered taxes and direct regulation as alternative policy instruments. Both instruments may in practice be imperfect, reflecting informational deficiencies and other limitations. We analyse the use of taxes and regulation in combination, to control externalities arising from individual consumption behaviour. We consider cases where taxes are either imperfectly differentiated to reflect individual differences in externalities, or where some consum...

Comparison of some European regulations

Energy Technology Data Exchange (ETDEWEB)

Argyriadis, K [Germanisher Lloyd, Hamburg (Germany)

1996-09-01

Fatigue calculations are an essential part in certification of a wind turbine. Manufacturers have to fulfill recommendations of several different regulations throughout Europe with the result that the design has often to be altered to satisfy them. In general three national (D/GL, NL, DK), and two international (GL, IEC) regulations are in use, with the IEC standard getting more importance with wind energy deploying to more in regions with no yet clearly defined national standards (India, Spain). The Germanischer Lloyd made calculations for wind turbines they are certifying and in one case we compared the resulting damages for different regulations and classes on a 600 kW, three bladed, stall regulated wind turbine. (EG) 18 refs.

Collaborative Tax Regulation

DEFF Research Database (Denmark)

Boll, Karen

2016-01-01

This article shows a new form of regulation within a tax administration where tax administrators abate tax evasion by nudging and motivating consumers to only purchase services from tax compliant businesses. This indirectly closes or forces tax evading businesses to change their practices, because...... stakeholders, i.e. the consumers, in the regulatory craft. The study is based on a qualitative methodology and draws on a unique case of regulation in the cleaning sector. This sector is at high risk of tax evasion and human exploitation of vulnerable workers operating in the informal economy. The article has...

Urban morphological determinants of temperature regulating ecosystem services in African cities: the case of Dar es Salaam, Tanzania

Science.gov (United States)

Cavan, Gina; Lindley, Sarah; Kibassa, Deusdedit; Shemdoe, Riziki; Capuano, Paolo; De Paola, Francesco; Renner, Florian; Pauleit, Stephan

2013-04-01

Urban green structure provides important regulating ecosystem services, such as temperature and flood regulation, and thus, has the potential to increase the resilience of African cities to climate change. Green structures within urban areas are not only limited to discrete units associated with recreational parks, agricultural areas and open spaces: they also exist within zones which have other primary functions, such as church yards, along transport routes, and within residential areas. Differing characteristics of urban areas can be conceptualised and subsequently mapped through the idea of urban morphology types. Urban morphology types are classifications which combine facets of urban form and function. When mapped, UMT units provide biophysically relevant meso-scale geographical zones which can be used as the basis for understanding climate-related impacts and adaptations. For example, they support the assessment of urban temperature patterns and the temperature regulating services provided by urban green structures. There are some examples of the use of UMTs for assessing regulating ecosystem services in European cities but little similar knowledge is available in an African context. This paper outlines the concept of urban morphology types (UMTs) and how they were applied to African case study cities (Cavan et al., 2012). It then presents the methods used to understand temperature regulating ecosystem services across an example African case study city, including (i) a GIS-based assessment of urban green structures, and (ii) applying an energy balance model to estimate current and future surface temperatures under climate change projections. The assessment is carried out for Dar es Salaam, Tanzania. Existing evidence suggests increases in both mean and extreme temperatures in the city. Historical analysis of the number of hot days per year suggests a rise from a maximum of 47 days per year in the period 1961-87 to 72 days per year in 2003-2011 (Giugni et al

"Opening an emotional dimension in me": changes in emotional reactivity and emotion regulation in a case of executive impairment after left fronto-parietal damage.

Science.gov (United States)

Salas, Christian E; Radovic, Darinka; Yuen, Kenneth S L; Yeates, Giles N; Castro, O; Turnbull, Oliver H

2014-01-01

Dysexecutive impairment is a common problem after brain injury, particularly after damage to the lateral surface of the frontal lobes. There is a large literature describing the cognitive deficits associated with executive impairment after dorsolateral damage; however, little is known about its impact on emotional functioning. This case study describes changes in a 72-year-old man (Professor F) who became markedly dysexecutive after a left fron-to-parietal stroke. Professor F's case is remarkable in that, despite exhibiting typical executive impairments, abstraction and working memory capacities were spared. Such preservation of insight-related capacities allowed him to offer a detailed account of his emotional changes. Quantitative and qualitative tools were used to explore changes in several well-known emotional processes. The results suggest that Professor F's two main emotional changes were in the domain of emotional reactivity (increased experience of both positive and negative emotions) and emotion regulation (down-regulation of sadness). Professor F related both changes to difficulties in his thinking process, especially a difficulty generating and manipulating thoughts during moments of negative arousal. These results are discussed in relation to the literature on executive function and emotion regulation. The relevance of these findings for neuropsychological rehabilitation and for the debate on the neural basis of emotional processes is addressed.

27 CFR 70.701 - Rules and regulations.

Science.gov (United States)

2010-04-01

..., Regulations and Forms § 70.701 Rules and regulations. (a) Formulation. (1) Alcohol, tobacco, and firearms... reaching the same conclusion in other cases unless the facts and circumstances are substantially the same...) Disclosure of secret formulas, processes, business practices, and other similar information. (iii)(A) It is...

Timing of adoption of clean technologies by regulated monopolies

Directory of Open Access Journals (Sweden)

Youssef Slim Ben

2015-01-01

Full Text Available We consider a monopoly firm producing a good and, at the same time, polluting and using fossil energy. By incurring an investment cost, this firm can adopt a lower production cost clean technology using renewable energy. We determine the optimal adoption date for the firm in the case where it is not regulated at all and in the case where it is regulated at each period. Interestingly, the regulated firm adopts the clean technology earlier than what is socially optimal, as opposed to the nonregulated firm. The regulator can induce the firm to adopt the clean technology at the socially optimal date by a postpone adoption subsidy. Nevertheless, the regulator may be interested in the earlier adoption of the firm to encourage the diffusion of the use of clean technologies in other industries.

Regulating Internalities

OpenAIRE

Sunstein, Cass Robert; Allcott, Hunt

2015-01-01

This paper offers a framework for regulating internalities. Using a simple economic model, we provide four principles for designing and evaluating behaviorally-motivated policy. We then outline rules for determining which contexts reliably reflect true preferences and discuss empirical strategies for measuring internalities. As a case study, we focus on energy efficiency policy, including Corporate Average Fuel Economy (CAFE) standards and appliance and lighting energy efficiency standards.

Environmental effects on hormonal regulation of testicular descent

DEFF Research Database (Denmark)

Toppari, J; Virtanen, H E; Skakkebaek, N E

2006-01-01

cause some cases of undescended testis. Similarly, androgen insensitivity or androgen deficiency can cause cryptorchidism. Estrogens have been shown to down regulate INSL3 and thereby cause maldescent. Thus, a reduced androgen-estrogen ratio may disturb testicular descent. Environmental effects changing......Regulation of testicular descent is hormonally regulated, but the reasons for maldescent remain unknown in most cases. The main regulatory hormones are Leydig cell-derived testosterone and insulin-like factor 3 (INSL3). Luteinizing hormone (LH) stimulates the secretion of these hormones...... hypothesize that an exposure to a mixture of chemicals with anti-androgenic or estrogenic properties (either their own activity or their effect on androgen-estrogen ratio) may be involved in cryptorchidism....

Risk based regulation: a convenient concept for legislation and regulation in the field of technical risks?

International Nuclear Information System (INIS)

Seiler, J.H.

1998-01-01

Legislation and regulation concerning risk activities are traditionally based on deterministic safety measures. This may lead to inefficient results: sometimes the law requires safety measures which are - from an economic viewpoint - not justified because of their poor cost-effectiveness; sometimes it does not require safety measures although they would be very efficient. The risk based regulation approach wants to make the law more efficient and to get more safety at less costs. Legislation and regulation should be based on terms of risk rather than on deterministic rules. Risk should be expressed in quantitative terms and risk regulation should be based on the cost-effectiveness of safety measures. Thus a most efficient (in the sense of the economic analysis of the law) strategy for safety and environmental law could be established. The approach is economically reasonable and theoretically convincing. Its practical implementation however raises a lot of technical and legal questions. The project 'Risk Based Regulation' (1996-1999), sponsored by the Swiss National Fund for Scientific Research, intends to evaluate the practical feasibility of the approach from a technical and a legal view. It contains a general part which describes the risk based regulation approach and its legal and technical questions, case studies which try to practically implement the risk based regulation approach; the case studies are: storage and management of explosives in the army, storage and management of explosives for non-military purposes, safety at work, accident prevention in the non-professional field (mainly road accidents), fire protection, transportation of dangerous goods, waste disposal: traditional waste, waste disposal: radioactive waste, nuclear energy (reactor safety), a synthesis with recommendations for the future legislation and regulation in the field of technical risks. The paper presents the project and its preliminary results. (author)

EMERGING COMMON LAW DECISIONS IN GOODWILL ACCOUNTING REGULATION

Directory of Open Access Journals (Sweden)

Radu-Daniel LOGHIN

2014-06-01

Full Text Available In respect to financial reporting, statutory accounting standards and regulations form only a part of the normative landscape. Considering the case of common law countries, besides these classic sources of norms and practices there is an alternative base for exercising the professional judgement of the accountant, the case law precedents which drive and supplement in cases accounting regulations. For the purpose of this paper, goodwill accounting is explored from a normative perspective which draws from case law precedents in Zimbabwe and South Africa, two emerging common law countries which share a rich common law heritage, resulting in a set of findings relevant to the understanding of the nature of goodwill as well as an understanding of the factors which lead to early adoption of International Accounting Standards.

Implementation of information systems at pharmacies - a case study from the re-regulated pharmacy market in Sweden.

Science.gov (United States)

Hammar, Tora; Ohlson, Mats; Hanson, Elizabeth; Petersson, Göran

2015-01-01

When the Swedish pharmacy market was re-regulated in 2009, Sweden moved from one state-owned pharmacy chain to several private pharmacy companies, and four new dispensing systems emerged to replace the one system that had previously been used at all Swedish pharmacies for more than 20 years. The aim of this case study was to explore the implementation of the new information systems for dispensing at pharmacies. The vendors of the four dispensing systems in Sweden were interviewed, and a questionnaire was sent to the managers of the pharmacy companies. In addition, a questionnaire was sent to 350 pharmacists who used the systems for dispensing prescriptions. The implementation of four new dispensing systems followed a strict time frame set by political decisions, involved actors completely new to the market, lacked clear regulation and standards for functionality and quality assurance, was complex and resulted in variations in quality. More than half of the pharmacists (58%) perceived their current dispensing system as supporting safe dispensing of medications, 26% were neutral and 15% did not perceive it to support a safe dispensing. Most pharmacists (80%) had experienced problems with their dispensing system during the previous month. The pharmacists experienced problems included reliability issues, usability issues, and missing functionality. In this case study exploring the implementation of new information systems for dispensing prescriptions at pharmacies in Sweden, weaknesses related to reliability, functionality and usability were identified and could affect patient safety. The weaknesses of the systems seem to result from the limited time for the development and implementation, the lack of comprehensive and evidence-based requirements for dispensing systems, and the unclear distribution of quality assurance responsibilities among involved stakeholders. Copyright © 2015 Elsevier Inc. All rights reserved.

7 CFR 1900.5 - Assignment of cases.

Science.gov (United States)

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false Assignment of cases. 1900.5 Section 1900.5 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS... REGULATIONS GENERAL Delegations of Authority § 1900.5 Assignment of cases. The State Director may, in writing...

Regulation of gas infrastructure expansion

International Nuclear Information System (INIS)

De Joode, J.

2012-01-01

The topic of this dissertation is the regulation of gas infrastructure expansion in the European Union (EU). While the gas market has been liberalised, the gas infrastructure has largely remained in the regulated domain. However, not necessarily all gas infrastructure facilities - such as gas storage facilities, LNG import terminals and certain gas transmission pipelines - need to be regulated, as there may be scope for competition. In practice, the choice of regulation of gas infrastructure expansion varies among different types of gas infrastructure facilities and across EU Member States. Based on a review of economic literature and on a series of in-depth case studies, this study explains these differences in choices of regulation from differences in policy objectives, differences in local circumstances and differences in the intrinsic characteristics of the infrastructure projects. An important conclusion is that there is potential for a larger role for competition in gas infrastructure expansion.

Reputational Sanctions in Private and Public Regulation

NARCIS (Netherlands)

J.G. van Erp (Judith)

2008-01-01

textabstractThis article analyses how reputation functions as a mechanism for social control in private and public regulation. It discusses three cases of private markets where reputation is a powerful and effective mechanism for social control. From the case studies, four characteristics of markets

The challenge of legitimizing spatially differentiated regulation

DEFF Research Database (Denmark)

Thorsøe, Martin Hvarregaard; Graversgaard, Morten; Noe, Egon

2017-01-01

Differentiating regulation is a promising approach to agri-environmental regulation that may potentially reduce the environmental impact of agriculture at the lowest possible costs for the farmers and society, but also possesses a number of challenges. In this article, we explore the challenges...... to the legitimacy of agri-environmental regulation that occurs when the regulatory regime changes from general regulation to differentiated regulation. The analysis is based on a case study of the implementation of the Buffer zone act in Denmark – a regulation that prevents agricultural production in a 10 (later 9......) meter fringe around selected waterbodies. We distinguish between two different ways of legitimizing: Producing knowledge and participation. We conclude that to harvest some of the obvious benefits of differentiated regulation a number of challenges must be resolved, 1) ensuring legitimacy...

Financial Flexibility in Highly Regulated Market: Indonesian Telecommunication Case during Tariff Pricing War

Directory of Open Access Journals (Sweden)

Y. Arief Rijanto

2016-07-01

Full Text Available In year 2008, regulation of Indonesian telecommunicationindustries changes due the tariff pricing war within Telecommunication operator. This regulation tie up the telecommunication operator and affect operating revenue margin.The needs of financial flexibility within tele communication firm is increased.Capex, operating revenue and reinvestment needs to be flexible must be inline with competition and change of technology. This paper goals is measuring financial flexibility based on Capex, operating revenue and re-investment needs.Re-investment needs by Telecommunication operator can be financed with or without financial flexibility. Data from year 2007 up to 2014 is selected to accommodate before and after changes of telecommunication regulation. The regulation effect to financial flexibility of telecommunication firm is still relevantbecause telecommunication industries by nature needs larger capital to re-new the telecommunication technology. Real options method will be used to measure financial flexibility.Keywords: Financial flexibility, Price war, Telecommunication Regulation, Real Option

Design of an eight-megawatt series regulator

International Nuclear Information System (INIS)

DeVore, K.R.

1977-01-01

An 8-MW, 100 percent duty cycle, hard tube series regulator used to control the accelerating voltage of a neutral beam source is described. The series tube is a developmental switch/regulator tube capable of holding off 200 kV passing 85 A, and dissipating 2 MW of anode power. The regulator has high-speed interrupt capability to minimize the power delivered to the load in the event of a load fault. Its design is such that it can be used to regulate both positive and negative accelerating voltages. All reference/control signals between the modulator and the control station use optical links to minimize noise interference and ground loop problems. In all cases of optical coupling, the loss of light is the worst-case condition, i.e., loss of light turns off the regulator. The fast interrupt is accomplished by rapid removal of the screen grid voltage from the series tube, and then driving the control grid into cutoff. After the control grid is in cutoff the screen is allowed to recover, and the regulator is then ready to switch back on. The regulator tube driver is a straightforward dc-coupled amplifier with a cathode follower output; dc isolation between various sections of the modulator is accomplished by using optical coupling. The use of optics allows the use of solid-state devices in an extremely hostile environment containing both electromagnetic and nuclear radiation

Co-operative approaches to regulation

National Research Council Canada - National Science Library

Huigen, Hans; Organisation for Economic Co-operation and Development

1997-01-01

... from traditional command-and-control regulation. The case studies are organized according to a common framework designed to give information about the specific design and use of the alternative, positive and negative results, and more generally...

Role of micro-RNAs in LRF and BCL6 oncogenes regulation

International Nuclear Information System (INIS)

Rainaldi, G.

2009-01-01

Micro RNAs (miRNAs) are short 20-22 nucleotide RNA molecules with an important role in the regulation of gene expression at the post-transcriptional level. MiRNA levels have been shown to change markedly in tumors and their expression profile is currently used to classify and diagnose some tumours. MiRNAs have been classified either as oncogenes (overespressed in tumors) or as tumor suppressor (down regulated), and in certain cases they can behave as both depending on the type of tumor. In many cases miRNAs and transcription factors interact directly so that transcriptional and post-transcriptional regulation of gene expression are finely regulated

Emotion Risk-Factor in Patients with Cardiac Diseases: The Role of Cognitive Emotion Regulation Strategies, Positive Affect and Negative Affect (A Case-Control Study).

Science.gov (United States)

Bahremand, Mostafa; Alikhani, Mostafa; Zakiei, Ali; Janjani, Parisa; Aghei, Abbas

2015-05-17

Application of psychological interventions is essential in classic treatments for patient with cardiac diseases. The present study compared cognitive emotion regulation strategies, positive affect, and negative affect for cardiac patients with healthy subjects. This study was a case-control study. Fifty subjects were selected using convenient sampling method from cardiac (coronary artery disease) patients presenting in Imam Ali medical center of Kermanshah, Iran in the spring 2013. Fifty subjects accompanied the patients to the medical center, selected as control group, did not have any history of cardiac diseases. For collecting data, the cognitive emotion regulation questionnaire and positive and negative affect scales were used. For data analysis, multivariate analysis of variance (MANOVA) Was applied using the SPSS statistical software (ver. 19.0). In all cognitive emotion regulation strategies, there was a significant difference between the two groups. A significant difference was also detected regarding positive affect between the two groups, but no significant difference was found regarding negative affect. We found as a result that, having poor emotion regulation strategies is a risk factor for developing heart diseases.

Emotion Risk-Factor in Patients With Cardiac Diseases: The Role of Cognitive Emotion Regulation Strategies, Positive Affect and Negative Affect (A Case-Control Study)

Science.gov (United States)

Bahremand, Mostafa; Alikhani, Mostafa; Zakiei, Ali; Janjani, Parisa; Aghaei, Abbas

2016-01-01

Application of psychological interventions is essential in classic treatments for patient with cardiac diseases. The present study compared cognitive emotion regulation strategies, positive affect, and negative affect for cardiac patients with healthy subjects. This study was a case-control study. Fifty subjects were selected using convenient sampling method from cardiac (coronary artery disease) patients presenting in Imam Ali medical center of Kermanshah, Iran in the spring 2013. Fifty subjects accompanied the patients to the medical center, selected as control group, did not have any history of cardiac diseases. For collecting data, the cognitive emotion regulation questionnaire and positive and negative affect scales were used. For data analysis, multivariate analysis of variance (MANOVA) was applied using the SPSS statistical software (ver. 19.0). In all cognitive emotion regulation strategies, there was a significant difference between the two groups. A significant difference was also detected regarding positive affect between the two groups, but no significant difference was found regarding negative affect. We found as a result that, having poor emotion regulation strategies is a risk factor for developing heart diseases. PMID:26234976

Synthetic Cannabis Overdose and Withdrawal in a Young Adult: A Case Report, Commentary on Regulation, and Review of the Literature.

Science.gov (United States)

Samaan, John; Ferrer, Gerardo F; Akinyemi, Boye; Junquera, Patricia; Oms, Juan; Dumenigo, Rhaisa

2016-01-01

Introduction . Marijuana has been used for its psychotropic effects including enhanced relaxation and perceptual alterations. However, the use of synthetic marijuana (SM) leads to more frequent and drastic side effects than the typical use of regular marijuana, owing to the fact that SM has a shorter duration and an earlier peak of action. Despite all the potential adverse health effects associated with SM use, current health policies on SM are very limited. It is believed that the popularity of SM has increased, due to its easy accessibility in the US and lack of detection in typical urine drug screens for THC. Case Report . One case presented is of a young adult patient, with histories of recurrent synthetic cannabis and recreational cannabis use, who had developed drastic physiological and psychiatric symptoms, including the development of acute-onset psychosis. Conclusion/Discussion . This case, as many others nationwide, exemplifies the impact of synthetic cannabinoid use and abuse in adolescents. Side effects and adverse health consequences of synthetic cannabinoid use warrant stricter regulations and policies in order to decrease psychiatric hospital admissions and associated healthcare costs.

Barriers to Construction Health and Safety Self-regulation: A Scoping Case of Nigeria

Directory of Open Access Journals (Sweden)

Umeokafor Nnedinma

2017-03-01

Full Text Available This scoping study builds on the recent uncovering that in terms of health and safety (H&S, the Nigerian construction industry is self-regulated in various forms, not unregulated and that the size of company can further explain H&S self-regulation. Consequently, the barriers identified through literature review were assessed using questionnaires. Analysis of the data collected from construction practitioners in Nigeria shows that ‘economic factors’ mostly explains the barriers to construction H&S self-regulation. This is followed by the ‘ability to self-regulate’ and ‘lack of awareness’. Furthermore, the results show significant differences among small, medium and large construction contractors on seven factors of which include ‘normative case’ factors, ‘H&S is a duty’, ‘H&S is the right thing’ and ‘unfair H&S standards or legislation’. Although a scoping study, the study draws attention to the barriers to construction H&S self-regulation in Nigeria and demonstrates an alternative to state regulation of H&S.

Southern states radiological emergency response laws and regulations

International Nuclear Information System (INIS)

1989-02-01

The radiological emergency response laws and regulations of the Southern States Energy Compact member states are in some cases disparate. Several states have very specific laws on radiological emergency response while in others, the statutory law mentions only emergency response to ''natural disasters.'' Some states have adopted extensive regulations on the topic; others have none. For this reason, any general overview must necessarily discuss laws and regulations in general terms

ACCOUNTING REGULATIONS FOR GOODWILL IN AN EMERGING COUNTRY- THE CASE OF ROMANIA

Directory of Open Access Journals (Sweden)

Raluca Valeria RATIU

2014-11-01

Full Text Available The International Accounting Standards Board (IASB has been promoting a worldwide accounting harmonization and convergence project for more than a decade now with the declared purpose to increase comparability of financial information worldwide. We conduct a historical and chronological analysis of the evolution of the Romanian accounting and audit regulations and their comparability to the international standards, following a period of more than two decades, post-communism until today. Romanian regulators have adopted many changes of the accounting regulations in a short period of time, moving from the International Accounting Standards (IAS partial adoption, to the European Union (EU directives, to International Financial Reporting Standards (IFRS. These changes have had an impact on the listed companies which have applied them.

Teaching and Learning Hand in Hand: Adaptive Teaching and Self-Regulated Learning

Science.gov (United States)

Randi, Judi

2017-01-01

This article presents case studies of two novice teachers and their mentors who, without formal knowledge of self-regulation theory, established a classroom environment that promoted self-regulated learning. This case was drawn from a larger descriptive study of novice teachers learning to integrate a student-centered visual literacy instructional…

Case law

International Nuclear Information System (INIS)

Anon.

2011-01-01

Ninth Circuit held that the NRC's environmental review did not comply with NEPA due to the agency's categorical refusal to consider the environmental impacts of terrorist attacks on the proposed ISFSI. The Ninth Circuit remanded the case for the NRC to fulfill its NEPA obligations. United States - Case law 2 - Judgment of a US District Court on an exemption from fire safety regulations: This case concerns the validity of an exemption that the US Nuclear Regulatory Commission (NRC) issued to a licensee from the NRC's fire safety regulations, which were promulgated in 1980. These regulations, among other things, mandate that barriers intended to protect redundant systems for shutting down reactor units shall be able to withstand fire for at least one hour and for longer if a nuclear power plant does not have fire detectors and an automatic fire suppression system. 14 The final rule that enacted these regulations granted licensees 30 days to apply for an exemption from any aspect of the NRC's fire safety programme. 15 The NRC's fire safety regulations with this exemption provision were upheld in Connecticut Light and Power Co. v NRC, 673 F.2d 525 (D.C. Cir. 1982), which held that the commission had the authority to enact these regulations and that the exemption provision was 'critical' to the programme

CO{sub 2} regulation. The case of Denmark

Energy Technology Data Exchange (ETDEWEB)

Tinggaard Svendsen, G. [Faculty of Business Administration, Dept. of Economics (Denmark)

1996-12-31

For economic, political, and administrative reasons, a mixed design of permit market, bubble and tax is preferable for CO{sub 2} regulation in Denmark. A CO{sub 2} market should be introduced for the private manufacturing sector in Denmark and an administratively set CO{sub 2} bubble should be introduced for the public electricity sector. Permits are then to be devaluated in year 2005 by 20%. A CO{sub 2} tax should be correctly set at a US dollar 50 level in year 2005 for households, transportation sector and private firms not participating in the CO{sub 2} market. (au) 49 p.

Ex Post Regulation as the Method of Sectoral Regulation in Electricity Sector

Directory of Open Access Journals (Sweden)

Rafał Nagaj

2017-10-01

Full Text Available Aim/purpose - The aim of the article is to present the essence of ex post approach to sectoral regulation, to show the advantages and disadvantages of ex post regulation and to answer the question whether it is worth using in the electricity sector. Design/methodology/approach - For this purpose, a critical analysis of expert literature was made and an empirical analysis of countries that have applied ex post regulation in the electricity sector in the European Union. Two research methods were used: a case study and a comparison of changes in price and quality of services. The research period covered the period 2000-2016. Findings - It was found that ex post regulation reduces regulatory costs, does not adversely affect the quality of service and long-term rates, gives businesses the freedom of decision-making and the ability to react quickly to changes in the economy. The main disadvantages of ex post regulation are the tendency for companies to over-estimate bills for consumers, the difficulty of pursuing claims by consumers and the need to shift regulatory risk to consumers. Research implications/limitations - In the paper there was identified a research gap, i.e. the effects of ex post regulation in the electricity sector in European Union countries where such regulation was applied. Identifying the research gap will help us understand what are the advantages and disadvantages of ex post regulation and will create a model for when it is good moment to implement this in the economy. Besides identifying the research gap, further studies will be required over ex post regulation. Originality/value/contribution - The additional value of the paper is the study of ex post regulation, its essence and types. The article analyzed the effects of ex post regulation in the electricity sector and provided valuable insights into the potential risks associated with this approach to economic regulation.

Financial Flexibility in Highly Regulated Market: Indonesian Telecommunication Case during Tariff Pricing War

Directory of Open Access Journals (Sweden)

Y. Arief Rijanto

2015-08-01

Full Text Available In year 2008, regulation of Indonesian telecommunicationindustries changes due the tariff pricing war within Telecommunication opera-tor. This regulation tie up the telecommunication operator and affect operating revenue margin.The needs of financial flexibility within tele-communication firm is increased.Capex, operating revenue and reinvestment needs to be flexible must be inline with competition and change of technology. This paper goals is measuring financial flexibility based on Capex, operating revenue and re-investment needs.Reinvestment needs by Telecommunication operator can be financed with or without financial flexibility. Data from year 2007 up to 2014 is selec-ted to accommodate before and after changes of telecommunication regulation. The regulation effect to financial flexibility of telecommu-nication firm is still relevantbecause telecommunication industries by nature needs larger capital to re-new the telecommunication technology. Real options method will be used to measure financial flexibility.

Developing Young Children's Self-Regulation through Everyday Experiences

Science.gov (United States)

Florez, Ida Rose

2011-01-01

Every child is different. Some have difficulty expressing their ideas verbally. Some struggle to get along with peers or follow classroom routines. In each case, however, one thing is the same: improved learning and behavior requires strong self-regulation skills. Children develop foundational skills for self-regulation in the first five years of…

Regulation and innovation dynamics for nanoresponsible development: The case of the French code de l'environnement L 523-1 to L 523-5

International Nuclear Information System (INIS)

Auplat, C; Slimane, S Ben

2015-01-01

This paper examines one aspect of innovation dynamics for nanoresponsible development: the links between regulation and innovation dynamics. It focuses on the case of the French Code de l'environnement, Articles L. 523-1 to L. 523-3. Articles L. 523-1 to L. 523-3 of the French environment code provide for the obligation to declare the quantities and uses of substances at nanoscale produced, distributed or imported in France. This procedure is intended to improve knowledge of these substances and their uses as well as of their markets and volumes sold, to ensure traceability and to collect available information on their toxicological and ecotoxicological properties. The paper builds on recent work on the emergence of a regulatory framework for nanotechnologies to take stock of the current situation in France, in the EU and globally and to explore how this specific law package may influence innovation and the shaping of new markets for nanobased materials. The study shows that nano-regulation does have an impact on innovation. However, the impact is not the same with EU regulation and with French regulation, and while EU regulation seems to create a favourable context for innovation, French regulation seems to do the opposite. With this study we hope to bring new perspectives to the field of the strategic management of innovation, and also to shed some light on the roles and challenges of institutions to facilitate nanoresponsible development. (paper)

Institutionalizing environmental protection through self-regulation: the case of environmental standards adoption in Lithuania.

Science.gov (United States)

Bileisis, Mantas; Misiune, Ieva

2017-04-01

The impacts of human activity in the environment have a global dimension, but there are no effective global governance instruments to enforce environmental standards. At the same time, many national governments lack incentives to pursue strict environmental policies. In this context, self-regulation is seen as an alternative venue to address environmental challenges. This work aims to identify factors that influence companies to engage in environmental self-regulation? For this aim in March 2015 a survey of 482 companies was conducted. The target group were companies operating in Lithuania that hold ISO14001 certificates - one of the most prolific instruments for self-regulation. The questionnaire was designed to test assumptions developed in new institutionalist literature which claim that common practices can emerge through isomorphism.- The results showed that the main motive for environmental self-regulation is the desire to improve company image, rather than protecting the environment per se. Another important finding was that the main source of pressure to adopt self-regulation was based less on the perceived demands but the customers. Rather the driver for the adoption was a feeling of a need no to fall behind industry leaders. Thus, normative isomorphism is the main mechanism through which environmental self-regulation proliferates. We claim for a rapid proliferation of environmental self-regulation perceived industry leaders need to be identified and they need to be persuaded that environmental standards are key for the development of the industry. However, this also raises questions of sustainability. Few industries have long standing leaders, and through successful investment and technological development new actors can arise and this may risk stalling or even reversing self-regulation.

Political institutions of electricity regulation: The case of Turkey

International Nuclear Information System (INIS)

Mustafa Durakoglu, S.

2011-01-01

Turkey has been going through a liberalization process in its electricity market over the last decade. So far, the regulatory content of the market reforms has been in the center of attention in the literature, to the negligence of regulatory governance. However, recent studies, which applied the theoretical insights of new institutional economics to utilities regulation, have demonstrated that political endowments of the country draw the boundaries to which extent such regulatory content can be effectively implemented. In line with these studies, this paper adopts an institutional approach and attempts to identify the political endowments of Turkey in order to further analyze whether the market reforms succeeded in bringing about sufficient checks to cure the institutional problems. In other words, the paper takes a picture of the overall regulatory arena. The results show that the current regulatory structure, especially government-regulator relations, yet fails to meet good regulatory governance criteria. The paper also provides some policy suggestions. - Highlights: → Regulatory governance matters as much as regulatory content. → Political institutions draw boundaries to the implementation of regulatory content. → Market reforms have been insufficient to bring about a true institutional change. → Institutional checks must be devised to limit government interference to the market.

48 CFR 50.103-5 - Processing cases.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Processing cases. 50.103-5 Section 50.103-5 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT... knowledge of individuals when documentary evidence is lacking, and audits if considered necessary to...

31 CFR 353.90 - Waiver of regulations.

Science.gov (United States)

2010-07-01

... Commissioner of the Public Debt, as designee of the Secretary of the Treasury, may waive or modify any provision or provisions of these regulations. He may do so in any particular case or class of cases for the... such action would not be inconsistent with law or equity, (b) if it does not impair any existing rights...

Synthetic Cannabis Overdose and Withdrawal in a Young Adult: A Case Report, Commentary on Regulation, and Review of the Literature

Directory of Open Access Journals (Sweden)

John Samaan

2016-01-01

Full Text Available Introduction. Marijuana has been used for its psychotropic effects including enhanced relaxation and perceptual alterations. However, the use of synthetic marijuana (SM leads to more frequent and drastic side effects than the typical use of regular marijuana, owing to the fact that SM has a shorter duration and an earlier peak of action. Despite all the potential adverse health effects associated with SM use, current health policies on SM are very limited. It is believed that the popularity of SM has increased, due to its easy accessibility in the US and lack of detection in typical urine drug screens for THC. Case Report. One case presented is of a young adult patient, with histories of recurrent synthetic cannabis and recreational cannabis use, who had developed drastic physiological and psychiatric symptoms, including the development of acute-onset psychosis. Conclusion/Discussion. This case, as many others nationwide, exemplifies the impact of synthetic cannabinoid use and abuse in adolescents. Side effects and adverse health consequences of synthetic cannabinoid use warrant stricter regulations and policies in order to decrease psychiatric hospital admissions and associated healthcare costs.

Investment and revenue cap under incentive regulation: The case study of the Norwegian electricity distributors

OpenAIRE

Zhang, Dengjun; Xie, Jinghua

2017-01-01

Source at https://doi.org/10.1080/23322039.2017.1400900 Electricity distribution operators are regulated as monopolies around the world. Incentive regulation is further applied to relate their allowed revenues (revenue cap) to cost efficiency and investment. Incentive regulation varies cross countries and has evolved over time for individual countries. Norway is one of the first countries reforming the network distributors by incentive regulation. Using the long time series data, we eval...

Developing power markets - Development of market place for meeting the demand - Case India, in transition from regulated to competitive structure

Energy Technology Data Exchange (ETDEWEB)

Kumar, Pranay; Sarkar, Prabhajit Kumar

2010-09-15

Power Market players of developing countries with supply deficit are exposed to a unique combination of price risk and quantity risk which is not the case with developed nations that have taken path of liberalization to open up their power markets. India has one of the largest generation capacities in the world, yet till recently the Indian Power sector was highly regulated. However, the last decade has witnessed many initiatives so as to make the sector market oriented. This paper provides opportunity for developing countries to learn from Indian experience of introducing competition in the power sector.

Regulating Internet Hate: A Flying Pig?

OpenAIRE

Alkiviadou, Natalie

2016-01-01

Abstract: This paper will assess the regulation of the internet in the ambit of hate speech expressed digitally through the internet. To do so, it will provide a definitional framework of hate speech, an overview of the internet’s role in the ambit of hate speech and consider the challenges in legally regulating online hate speech through a discussion of relevant\\ud case-law as well as the Additional Protocol to the Cybercrime Convention. The jurisprudential analysis will allow for a comparis...

Improvement and rationalization of nuclear energy laws and regulations

International Nuclear Information System (INIS)

Cho, Byung Sun; Lee, Mo Sung; Chung, Gum Chum; Kim, Hak Man; Oh, Ho Chul

2002-03-01

Since the present legal system on nuclear safety regulation has some problems that refer to contents of regulatory provisions, this mid-report has preformed research on the legal basic theory of nuclear safety regulation. And then secondly this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation. In order to interpret easily this report finally took the cases of judicial precedents on nuclear safety regulation in USA, Germany, Japan and Korea

Improvement and rationalization of nuclear energy laws and regulations

Energy Technology Data Exchange (ETDEWEB)

Lee, Mo Sung; Chung, Gum Chun; Kim, Hak Man; Oh, Ho Chul [Cheongju Univ., Cheongju (Korea, Republic of)

2001-03-15

Since the present legal system on nuclear safety regulation has some problems that refer to contents of regulatory provisions, this mid-report has preformed research on the legal basic theory of nuclear safety regulation. And then secondly this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation. In order to interpret easily this report finally took the cases of judicial precedents on nuclear safety regulation in USA, Germany, Japan and Korea.

Improvement and rationalization of nuclear energy laws and regulations

Energy Technology Data Exchange (ETDEWEB)

Cho, Byung Sun; Lee, Mo Sung; Chung, Gum Chum; Kim, Hak Man; Oh, Ho Chul [Chongju Univ., Cheongju (Korea, Republic of)

2002-03-15

Since the present legal system on nuclear safety regulation has some problems that refer to contents of regulatory provisions, this mid-report has preformed research on the legal basic theory of nuclear safety regulation. And then secondly this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation. In order to interpret easily this report finally took the cases of judicial precedents on nuclear safety regulation in USA, Germany, Japan and Korea.

Evolving Role of the Power Sector Regulator: A Clean Energy Regulators Initiative Report

Energy Technology Data Exchange (ETDEWEB)

Zinaman, O.; Miller, M.; Bazilian, M.

2014-04-01

This paper seeks to briefly characterize the evolving role of power sector regulation. Given current global dynamics, regulation of the power sector is undergoing dramatic changes. This transformation is being driven by various factors including technological advances and cost reductions in renewable energy, energy efficiency, and demand management; increasing air pollution and climate change concerns; and persistent pressure for ensuring sustainable economic development and increased access to energy services by the poor. These issues add to the already complex task of power sector regulation, of which the fundamental remit remains to objectively and transparently ensure least-cost service delivery at high quality. While no single regulatory task is trivial to undertake, it is the prioritization and harmonization of a multitude of objectives that exemplifies the essential challenge of power sector regulation. Evolving regulatory roles can be understood through the concept of existing objectives and an additional layer of emerging objectives. Following this categorization, we describe seven existing objectives of power sector regulators and nine emerging objectives, highlighting key challenges and outlining interdependencies. This essay serves as a preliminary installment in the Clean Energy Regulatory Initiative (CERI) series, and aims to lay the groundwork for subsequent reports and case studies that will explore these topics in more depth.

Transcriptional regulation of respiration in yeast metabolizing differently repressive carbon substrates

OpenAIRE

Fendt, Sarah-Maria; Sauer, Uwe

2010-01-01

Abstract Background Depending on the carbon source, Saccharomyces cerevisiae displays various degrees of respiration. These range from complete respiration as in the case of ethanol, to almost complete fermentation, and thus very low degrees of respiration on glucose. While many key regulators are known for these extreme cases, we focus here on regulators that are relevant at intermediate levels of respiration. Results We address this question by linking the functional degree of respiration t...

The regulation of social education as a profession: an analysis of the processes of regulation of the identity and socio-professional status of the social educator in Portugal and Brazil

OpenAIRE

Henrique Pereira Ramalho

2017-01-01

This article deals with the processes of regulation of the exercise of social education as a profession that we consider as emergent (in the portuguese case) and diffuse (in the brazilian case). In the first case, we look at an institutional logic of the profession, in which self-regulation processes are more prevalent, although they resort to petitioning procedures through which, and in a subsidiary way, they seek to "fit in" the profession of social educator in the "world” of the segmented ...

Regulation of mariner transposition: the peculiar case of Mos1.

Directory of Open Access Journals (Sweden)

Jérôme Jaillet

Full Text Available BACKGROUND: Mariner elements represent the most successful family of autonomous DNA transposons, being present in various plant and animal genomes, including humans. The introduction and co-evolution of mariners within host genomes imply a strict regulation of the transposon activity. Biochemical data accumulated during the past decade have led to a convergent picture of the transposition cycle of mariner elements, suggesting that mariner transposition does not rely on host-specific factors. This model does not account for differences of transposition efficiency in human cells between mariners. We thus wondered whether apparent similarities in transposition cycle could hide differences in the intrinsic parameters that control mariner transposition. PRINCIPAL FINDINGS: We find that Mos1 transposase concentrations in excess to the Mos1 ends prevent the paired-end complex assembly. However, we observe that Mos1 transposition is not impaired by transposase high concentration, dismissing the idea that transposase over production plays an obligatory role in the down-regulation of mariner transposition. Our main finding is that the paired-end complex is formed in a cooperative way, regardless of the transposase concentration. We also show that an element framed by two identical ITRs (Inverted Terminal Repeats is more efficient in driving transposition than an element framed by two different ITRs (i.e. the natural Mos1 copy, the latter being more sensitive to transposase concentration variations. Finally, we show that the current Mos1 ITRs correspond to the ancestral ones. CONCLUSIONS: We provide new insights on intrinsic properties supporting the self-regulation of the Mos1 element. These properties (transposase specific activity, aggregation, ITR sequences, transposase concentration/transposon copy number ratio... could have played a role in the dynamics of host-genomes invasion by Mos1, accounting (at least in part for the current low copy number of

Regulation of alcohol advertising: Policy options for Australia

Directory of Open Access Journals (Sweden)

Sandra C. Jones

2013-06-01

Full Text Available A systematic search of academic databases was conducted to identify all refereed papers published between 1990 and 2012 on the regulation of alcohol advertising in Australia and three comparison countries (New Zealand, Canada and the UK. This paper reviews the codes that apply to alcohol advertising in each of the four countries, research into the effectiveness of these codes, and the small body of research into consumer attitudes towards alcohol advertising regulation. This review adduces considerable evidence that alcohol advertising influences drinking behaviours, and that current regulatory systems based on co-regulation and voluntary regulation (as is the case in Australia are ineffective. Recommendations are provided regarding the three pillars of regulation: volume restrictions, content restrictions, and infrastructure to support the regulatory environment.

Regulatory Oversight for New Projects - Challenges and Improvement in Regulation

International Nuclear Information System (INIS)

Lall, F.

2016-01-01

From inception, there has been rise in number of Nuclear Power Plants (NPP) even though very few accidents / events led to intermittent setbacks. However these accidents / events have posed challenges towards enhancement of safety and scope of regulation in all phases of NPP such as siting, design, construction, commissioning and decommissioning. It is essential to ensure compliance to these enhanced safety requirements during all phases of NPP. New and evolutionary reactors are under threshold for regulatory consideration world over. The variety of technologies and genres by themselves pose challenges to regulatory bodies. These challenges are to be addressed through systematic enhancement of the regulation including updating of regulatory documents. The paper touches upon some key elements to be considered towards such enhancement of regulation during all stages of NPP. These being; ensuring quality assurance, regulatory oversight especially over supply chain and contractors, counterfeit material specifically in case of international dealings, emergency handling in case of multi-unit site, feedback and associated enhancements from international events, construction experience database and feedback for safety enhancement, qualification and acceptance of first of a kind systems, regulatory enforcement specifically in case of imported reactors and maintaining interface between safety and security. Regulation in present context has become dynamic and Regulatory bodies need to continue enhancement of its current regulation taking into account the technological developments, feedback from construction, operation and accidents in the current fleet of plants. The paper touches upon some of these elements and highlights the challenges and improvements in regulation. (author)

Price regulation and international resource supply

Energy Technology Data Exchange (ETDEWEB)

Siebert, H

1982-03-01

Price regulation is an instrument between two diverging aims: The demand for low resource prices motivated by the principle of equal distribution in our day, and the desire for economical management of resources as a responsibility we have to future generations. The present publication investigates how price regulation influences intertemporal supply of resources. For the assumed cases constant resource price, constant admissible increase in resource price, expected release of resource price and deregulation of a price held constant for a period of time mathematical models are developmed.

Enforcing planning regulations in areas of high immigration: a case study of London

OpenAIRE

Harris, Neil

2017-01-01

This paper explores the interface between immigration and compliance with planning regulations using data from interviews and a focus group with senior planning enforcement officers in London. The data reveal distinctive issues that arise for immigrants’ compliance with planning regulations; specific types of residential, commercial and cultural breach that occur with immigration; and operational issues that arise when investigating and resolving planning breaches involving immigrant communit...

[Critical considerations on the legal regulation of sex selection (Part I)].

Science.gov (United States)

Pérez Alonso, Esteban Juan

2002-01-01

Gender selection, and particularly its regulation, is a controversial issue. The author discusses the current problems surrounding gender selection from the very beginnings, and illustrates his views with an actual and controversial case in which a woman allowed to undergo artificial insemination was given the possibility of choosing the sex of her child. The author also discusses possible solutions and the penal, administrative regulation of the issue, as well as examining the court's decision in this particular case.

Oligoadenylate synthetase 1 (OAS1 expression in human breast and prostate cancer cases, and its regulation by sex steroid hormones

Directory of Open Access Journals (Sweden)

Cláudio Jorge Maia

2016-06-01

Full Text Available Oligoadenylate synthetase 1 (OAS1 is an interferon-induced protein characterised by its capacity to catalyse the synthesis of 2ʹ-5ʹ-linked oligomers of adenosine from adenosine triphosphate (2-5A. The 2-5A binds to a latent Ribonuclease L (RNase L, which subsequently dimerises into its active form and may play an important role in the control of cell growth, differentiation and apoptosis. Previously, our research group identified OAS1 as a differentially-expressed gene in breast and prostate cancer cell lines when compared to normal cells. This study evaluates: i the expression of OAS1 in human breast and prostate cancer specimens; and ii the effect of sex steroid hormones in regulating the expression of OAS1 in breast (MCF-7 and prostate (LNCaP cancer cell lines. The obtained results showed that OAS1 expression was down-regulated in human infiltrative ductal carcinoma of breast, adenocarcinoma of prostate, and benign prostate hyperplasia, both at mRNA and protein level. In addition, OAS1 expression was negatively correlated with the progression of breast and prostate cancer. With regards to the regulation of OAS1 gene, it was demonstrated that 17β-estradiol (E2 down-regulates OAS1 gene in MCF-7 cell lines, an effect that seems to be dependent on the activation of oestrogen receptor (ER. On the other hand, 5α-dihydrotestosterone (DHT treatment showed no effect on the expression of OAS1 in LNCaP cell lines. The lower levels of OAS1 in breast and prostate cancer cases indicated that the OAS1/RNaseL apoptotic pathway may be compromised in breast and prostate tumours. Moreover, the present findings suggested that this effect may be enhanced by oestrogen in ER-positive breast cancers.

Work place regulations - effects on power station construction

International Nuclear Information System (INIS)

Richter, E.

1979-01-01

The paper describes that the Workplace Order and Workplace Regulations cannot be applied in every area of a conventional power station or the conventional sections of nuclear power stations. In any case extensive regulations already exist for the hot regions of nuclear power stations. A proposal is made as to which areas of power stations should be developed in accordance with the Workplace Order and the Workplace Regulations and which areas are not deemed to be 'Workplaces'. This is illustrated with the aid of typical examples. (orig.) [de

Multicriteria analysis of protection actions in the case of transportation of radioactive materials: Regulating the transit of type A packages through the Mont Blanc Tunnel

International Nuclear Information System (INIS)

Hubert, P.; Lombard, J.; Pages, P.

1986-09-01

The utility function approach (decision analysis) is one of the classical decision aiding techniques that are of interest when performing ALARA analysis. In this paper a case study will serve as an illustration of this technique. The problem which is dealt with is the set up of a regulation applying to the transit of small radioactive material packages (type A) under the Mont Blanc Tunnel which is a major route between France and Italy. This case study is therefore a good example of an ALARA approach applied to a safety problem which implies both a probabilistic risk assessment and the evaluation of very heterogeneous criteria

Renewable resource regulation and uncertain prices: The role of financial structure and bankruptcy

International Nuclear Information System (INIS)

Damania, Richard; Bulte, Erwin H.

2006-01-01

We analyze the interaction between regulatory policies and the financial structure of a fishery and show that firms with debts may respond differently to regulations than firms that have not accumulated debts. There are conditions where more stringent regulation is counterproductive, providing a perverse incentive to increase harvesting effort. We show that optimal regulation depends on the sector's financial structure, and demonstrate that there are cases when intervention is counterproductive, or too costly to implement. There are also cases where successful regulatory intervention can only be implemented when accompanied by a sufficiently large subsidy. (author)

77 FR 3636 - Federal Acquisition Regulation; Brand-Name Specifications; Correction

Science.gov (United States)

2012-01-25

... 26] RIN 9000-AK55 Federal Acquisition Regulation; Brand-Name Specifications; Correction AGENCY... Regulation (FAR) to implement the Office of Management and Budget memoranda on brand-name specifications, FAR Case 2005-037, Brand-Name Specifications, which published in the Federal Register at 77 FR 189 on...

Exploring car manufacturers' responses to technology-forcing regulation : The case of California's ZEV mandate

NARCIS (Netherlands)

Wesseling, Joeri; Farla, J. C M; Hekkert, M. P.

2015-01-01

The ability of firms to influence environmental regulation has largely been overlooked in transition studies. We study how car manufacturers combine and change their innovation and political influence strategies in response to a technology-forcing regulation. We apply a conceptual framework on

Renal blood flow regulation and arterial pressure fluctuations: a case study in nonlinear dynamics

DEFF Research Database (Denmark)

Holstein-Rathlou, N H; Marsh, D J

1994-01-01

in which the kidney is obliged to operate. Were it not for renal blood flow autoregulation, it would be difficult to regulate renal excretory processes so as to maintain whole body variables within narrow bounds. Autoregulation is the noise filter on which other renal processes depend for maintaining...... a relatively noise-free environment in which to work. Because of the time-varying nature of the blood pressure, we have concentrated in this review on the now substantial body of work on the dynamics of renal blood flow regulation and the underlying mechanisms. Renal vascular control mechanisms are not simply....... The significance of deterministic chaos in the context of renal blood flow regulation is that the system regulating blood flow undergoes a physical change to a different dynamical state, and because the change is deterministic, there is every expectation that the critical change will yield itself to experimental...

Teaching Organizational Skills through Self-Regulated Learning Strategies

Science.gov (United States)

Cahill, Susan M.

2008-01-01

This article presents a case story of how an occupational therapist worked with Joe, a junior high student with Asperger's Syndrome, to develop better organizational skills. Self-regulated learning strategies were used to teach Joe how to keep track of his assignments as well as his grades. In addition, the case story provides a clear example of…

Assessment of safety regulation using an artificial society

International Nuclear Information System (INIS)

Furuta, Kazuo; Nagase, Masaya

2005-01-01

This study proposes using an artificial society to assess impacts of safety regulation on the society. The artificial society used in this study is a multi-agent system, which consists of many agents representing companies. The agents cannot survive unless they get profits by producing some products. Safety regulation functions as the business environment, which the agents will evolve to fit to. We modeled this process of survival and adaptation by the genetic algorithm. Using the proposed model, case simulations were performed to compare various regulation styles, and some interesting insights were obtained how regulation style influences behavior of the agents and then productivity and safety level of the industry. In conclusion, an effective method for assessment of safety regulation has been developed, and then several insights were shown in this study

Legal regulation of online advertising in the Czech Republic

OpenAIRE

Sládek, Ondřej

2012-01-01

The thesis focuses on regulation of advertising on the Internet. The aim of the thesis is to evaluate the current state and position of public regulation of online advertising, both in general and on the example of Google advertising network. The approach to achieve defined goals is to first present a theoretical overview of the legal regulation of advertising with an emphasis on online advertising, followed by a case study showing the practical functioning of online advertising rules in Goog...

77 FR 76938 - Defense Federal Acquisition Regulation Supplement: Contracting Activity Updates (DFARS Case 2012...

Science.gov (United States)

2012-12-31

... Security Cooperation Agency, the Defense Security Service, the Defense Threat Reduction Agency, the Missile... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 202 RIN 0750-AH81 Defense...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is...

APPLICABILITY OF CONSOLIDATED TECHNIQUES IN THE VIEW OF ROMANIAN ACCOUNTING REGULATIONS

Directory of Open Access Journals (Sweden)

Cristina Rosu

2016-06-01

Full Text Available The accounting regulations are more and more interested in groups of companies. In some cases, these regulations require for preparing the consolidated financial statements. This is the task of the parent company who keeps the consolidated accounts. To accomplish its goals, the consolidated accounting uses a couple of, so-called, consolidation techniques. These are applied in the case of groups of companies with a complex structure. Their goal is to elaborate the consolidated financial statements using a set of methods and empirical skills. In this article we synthetize and apply the consolidation techniques in the view of Romanian accounting regulations. The Romanian practice has revealed, especially, two techniques: one based on direct consolidation and another one based on multiple levels (phased consolidation. Therefore, this work regards only the technical side of consolidated accounting, accounting records being evaded. Furthermore, we focus only on the preparation of the consolidated balance sheet in the case of some hypothetical groups of companies.

Regulation of biogenerics: a survey of viewpoints.

Science.gov (United States)

Nieminen, Outi; Nordström, Katrina

2004-01-01

'Biogenerics' regulation has brought about a heated debate within the EU as the first biopharmaceuticals are going off patent. This study aims to examine the opportunities and challenges offered by biogenerics by surveying the viewpoints of experts in regulatory agencies and in companies developing novel biopharmaceuticals and biogenerics. Oral interviews were conducted in 2002 and 2003 with experts including representatives of the European Generic Medicines Association (EGA) and the European Federation of Pharmaceutical Industries and Associations (EFPIA) in Brussels, three innovator biotech companies, and five other experts in Finland. Additionally, four biogenerics companies and one innovator company abroad answered a structured, written questionnaire. According to this study, biogenerics should be regulated on a case-by-case basis. The interviewees were not unanimous as to whether comparability can be addressed and which are the most challenging areas for proving comparability. Immunogenicity was considered to be a major problem for biogenerics. Therefore, a requirement for an intensified monitoring of the safety profile during post-marketing was thought to be justified in many cases.

Regulations for radiochemical facilities in the United States

International Nuclear Information System (INIS)

Emeigh, Ch; Smith, B.; Williams, T

1999-01-01

Material control and accounting is implemented to provide assurance that physical protection measures have been effective, and in case they fail, to provide delayed detection of the loss. Regulations in the United States have been developed that include both performance and compliance requirements to provide a defence in depth approach addressing the unique characteristics of each facility. Regulations address administrative controls, material control and material accounting. Nuclear materials control and accounting plans are negotiated between regulatory agencies and facilities to develop a site-specific approach. An overview of the regulations and their implementation in the United State is provided [ru

8MVA modulator/regulator for neutral beams

International Nuclear Information System (INIS)

Remsen, D.B. Jr.; Overett, T.H.

1980-05-01

This paper describes very generally the modulator/regulator (Mod/Reg) being built for Transrex by Systems, Science and Software for use on the neutral beam power supplies that Transrex is building for General Atomic Company to power the neutral beam heating systems that will be used on the Doublet III fusion device. The Mod/Reg is required to provide an 80 kV, 100 A pulse for a second every 90 sec. The voltage is to be regulated to 3%, and in case of fault the pulse must be interrupted within 10 μsec. An additional requirement was that the total system have very low capacity such that the total energy stored would be less than 15 joules. This is a restriction imposed by the source designer to prevent destroying the source in case of an arc within the source

Pollution Under Environmental Regulation in Energy Markets

CERN Document Server

Gullì, Francesco

2013-01-01

Pollution Under Environmental Regulation in Energy Markets provides a study of environmental regulation when energy markets are imperfectly competitive. This theoretical treatment focuses on three relevant cases of energy markets. First, the residential space heating sector where hybrid regulation such as taxation and emissions trading together are possible. Second, the electricity market where transactions are organized in the form of multi-period auctions. Third, namely natural gas (input) and electricity (output) markets where there is combined imperfect competition in vertical related energy markets.   The development of free or low carbon technologies supported by energy policies, aiming at increasing security of supply, is also explored whilst considering competition policies that reduce market power in energy markets thus improving market efficiency. Pollution Under Environmental Regulation in Energy Markets discusses the key issues of whether imperfect competition can lessen the ability of environmen...

Plug-in hybrid electric vehicles as regulating power providers. Case studies of Sweden and Germany

International Nuclear Information System (INIS)

Andersson, S.-L.; Goeransson, L.; Karlsson, S.; Johnsson, F.; Elofsson, A.K.; Galus, M.D.; Andersson, G.

2010-01-01

This study investigates plug-in hybrid electric vehicles (PHEVs) as providers of regulating power in the form of primary, secondary and tertiary frequency control. Previous studies have shown that PHEVs could generate substantial profits while providing ancillary services. This study investigates under what conditions PHEVs can generate revenues using actual market data, i.e. prices and activations of regulating power, from Sweden and Germany from four months in 2008. PHEV market participation is modelled for individual vehicles in a fleet subject to a simulated movement pattern. Costs for infrastructure and vehicle-to-grid equipment are not included in the analysis. The simulation results indicate that maximum average profits generated on the German markets are in the range 30-80 EUR per vehicle and month whereas the Swedish regulating power markets give no profit. In addition, an analysis is performed to identify strengths, weaknesses, opportunities, and threats (SWOT) of PHEVs as regulating power providers. Based on the simulation results and the SWOT analysis, characteristics for an ideal regulating power market for PHEVs are presented. (author)

CLP Regulation and the transport of dangerous goods

Directory of Open Access Journals (Sweden)

Sergio Benassai

2011-01-01

Full Text Available Regulations concerning different modes of transport of dangerous goods are well harmonized at global level: they were then looked at as a model for developing Globally Harmonized System of Classification and Labelling of Chemicals (GHS, (on which CLP Regulations is based. Transport regulations do not cover some hazard classes, such as germ cell mutagenicity, carcinogenicity, reproductive toxicity, having been evaluated that such hazards are not relevant in transport because in general, in case of accident, no repeated and prolonged exposure takes place. Other differences with CLP Regulation are related to the use of "building block approach". Transport labels, which were used as a basis for GHS, can be used, instead of CLP pictograms, on packages during transport.

Regulation of Translation Initiation under Biotic and Abiotic Stresses

Directory of Open Access Journals (Sweden)

Ana B. Castro-Sanz

2013-02-01

Full Text Available Plants have developed versatile strategies to deal with the great variety of challenging conditions they are exposed to. Among them, the regulation of translation is a common target to finely modulate gene expression both under biotic and abiotic stress situations. Upon environmental challenges, translation is regulated to reduce the consumption of energy and to selectively synthesize proteins involved in the proper establishment of the tolerance response. In the case of viral infections, the situation is more complex, as viruses have evolved unconventional mechanisms to regulate translation in order to ensure the production of the viral encoded proteins using the plant machinery. Although the final purpose is different, in some cases, both plants and viruses share common mechanisms to modulate translation. In others, the mechanisms leading to the control of translation are viral- or stress-specific. In this paper, we review the different mechanisms involved in the regulation of translation initiation under virus infection and under environmental stress in plants. In addition, we describe the main features within the viral RNAs and the cellular mRNAs that promote their selective translation in plants undergoing biotic and abiotic stress situations.

Development and action plan for the alternative regulation instruments

International Nuclear Information System (INIS)

Kim, Jung Yul; Hagm, Yo Sang

2004-02-01

The goal of this study to provide highly practical model, needed for regulation if nuclear power safety to regulation agency. Since nuclear power safety regulation has different characteristics, compared to general regulation, it is important to have new point of view and approach. But application possibility for regulation that guarantees the 'perfect safety' is very low. Therefore, it is important establish nuclear power safety regulation that is realistic as well as safety securing. In order to establish high quality regulation, evaluation of existing regulation must be done first. Thus in this study, 6 standards to evaluate existing regulation are suggested. They are clearness, efficiency, flexibility, reliability, responsibility and political consideration. Also, strategies to complement the weak points of regulatory governance, regulatory sunset, regulatory map, regulatory negotiation, regulatory benefit-cost analysis, etc. These strategies can be applied all in one regulation, and can strategically be selected for application. After analyzing the result if case analysis on nuclear furnace regulation for research study, agreement was made that it is most efficient to consider in the order if clearness reliability, flexibility, confidence, political consideration, administrative efficiency and economic efficiency

Development and action plan for the alternative regulation instruments

Energy Technology Data Exchange (ETDEWEB)

Kim, Jung Yul [Daegu Univ., Gyeongsan (Korea, Republic of); Hagm, Yo Sang [Korea Univ., Seoul (Korea, Republic of)

2004-02-15

The goal of this study to provide highly practical model, needed for regulation if nuclear power safety to regulation agency. Since nuclear power safety regulation has different characteristics, compared to general regulation, it is important to have new point of view and approach. But application possibility for regulation that guarantees the 'perfect safety' is very low. Therefore, it is important establish nuclear power safety regulation that is realistic as well as safety securing. In order to establish high quality regulation, evaluation of existing regulation must be done first. Thus in this study, 6 standards to evaluate existing regulation are suggested. They are clearness, efficiency, flexibility, reliability, responsibility and political consideration. Also, strategies to complement the weak points of regulatory governance, regulatory sunset, regulatory map, regulatory negotiation, regulatory benefit-cost analysis, etc. These strategies can be applied all in one regulation, and can strategically be selected for application. After analyzing the result if case analysis on nuclear furnace regulation for research study, agreement was made that it is most efficient to consider in the order if clearness reliability, flexibility, confidence, political consideration, administrative efficiency and economic efficiency.

Deliberative democracy and co-management of natural resources: The case of Funäsdalen snowmobile regulation area

Directory of Open Access Journals (Sweden)

Anna Karin Elise Zachrisson

2009-09-01

Full Text Available The purpose of this article is to deepen the understanding of how co-management and deliberative democracy relate to one another. Deliberation is an understudied aspect of common-pool resource theory that could be developed by a closer connection to deliberative democratic theory. Co-management studies may also provide needed empirical insights to deliberative democratic theory. A framework is developed to analyze to what degree co-management arrangements incorporate deliberative elements. To test its usefulness, a case study of a co-management process in Sweden is analyzed. In Funäsdalsfjällen, a conflict-ridden situation caused by snowmobiles ended in agreement and the establishment of a municipal regulation area. Central and regional authorities initially failed to resolve the conflict, but when the municipality started working directly with the relevant interest groups, agreement was reached. Deliberative elements are shown central to the success, and it is concluded that co-management and deliberative democratic approaches indeed do cross-fertilize one another.

Middle Ear Pressure Regulation - Complementary Action of the Mastoid and Eustachian Tube

DEFF Research Database (Denmark)

Gaihede, Michael; Dirckx, Joris J J; Jacobsen, Henrik

2010-01-01

, MEP counter-regulation presented as Eustachian tube openings with steep and fast pressure changes toward 0 Pa, whereas in others, gradual and slow pressure changes presented related to the mastoid; these changes sometimes crossed 0 Pa into opposite pressures. In many cases, combinations...... to continuous regulation of smaller pressures, whereas the tube was related to intermittent regulation of higher pressures....

Middle Ear Pressure Regulation - Complementary Action of the Mastoid and Eustachian Tube

DEFF Research Database (Denmark)

Gaihede, Michael; Jacobsen, Henrik; Tveterås, Kjell

, MEP counter-regulation presented as Eustachian tube openings with steep and fast pressure changes toward 0 Pa, whereas in others, gradual and slow pressure changes presented related to the mastoid; these changes sometimes crossed 0 Pa into opposite pressures. In many cases, combinations...... to continuous regulation of smaller pressures, whereas the tube was related to intermittent regulation of higher pressures....

Sustainable Trade Credit and Replenishment Policies under the Cap-And-Trade and Carbon Tax Regulations

Directory of Open Access Journals (Sweden)

Juanjuan Qin

2015-12-01

Full Text Available The paper considers the sustainable trade credit and inventory policies with demand related to credit period and the environmental sensitivity of consumers under the carbon cap-and-trade and carbon tax regulations. First, the decision models are constructed under three cases: without regulation, carbon cap-and-trade regulation, and carbon tax regulation. The optimal solutions of the retailer in the three cases are then discussed under the exogenous and endogenous credit periods. Finally, numerical analysis is conducted to obtain conclusions. The retailer shortens the trade credit period as the environmental sensitivity of the consumer is enhanced. The cap has no effects on the credit period decisions under the carbon cap-and-trade regulation. Carbon trade price and carbon tax have negative effects on the credit period. The retailer under carbon cap-and-trade regulation is more motivated to obey regulations than that under carbon tax regulation when carbon trade price equals carbon tax. Carbon regulations have better effects on carbon emission reduction than with exogenous credit term when the retailer has the power to decide with regards credit policies.

Smart-grid investments, regulation and organization

International Nuclear Information System (INIS)

Agrell, Per J.; Bogetoft, Peter; Mikkers, Misja

2013-01-01

Grid infrastructure managers worldwide are facing demands for reinvestments in new assets with higher on-grid and off-grid functionality in order to meet new environmental targets. The roles of the current actors will change as the vertical interfaces between regulated and unregulated tasks become blurred. In this paper, we characterize some of the effects of new asset investments policy on the network tasks, assets and costs and contrast this with the assumptions of the current economic network regulation. To provide structure, we present a model of investment provision under regulation between a distribution system operator and a potential investor–generator. The results from the model confirm the hypothesis that network regulation should find a focal point, should integrate externalities in the performance assessment and should avoid wide delegation of contracting-billing for smart-grid investments. - Highlights: ► We review regulatory solutions for smart-grid and DER investments. ► What matters more than upfront incentives is organization and delegation. ► We model regulated investment under private information by a generator or a DSO. ► Highest welfare for high-powered incentives and centralized information. ► Market approaches likely to give poor outcomes for this case.

Risk-based regulation: A regulatory perspective

International Nuclear Information System (INIS)

Scarborough, J.C.

1993-01-01

In the early development of regulations for nuclear power plants, risk was implicitly considered through qualitative assessments and engineering reliability principles and practices. Examples included worst case analysis, defense in depth, and the single failure criterion. However, the contributions of various systems, structures, components and operator actions to plant safety were not explicitly assessed since a methodology for this purpose had not been developed. As a consequence of the TMI accident, the use of more quantitative risk methodology and information in regulation such as probabilistic risk analysis (PRA) increased. The use of both qualitative and quantitative consideration of risk in regulation has been a set of regulations and regulatory guides and practices that ensure adequate protection of public health and safety. Presently, the development of PRA techniques has developed to the point that safety goals, expressed in terms of risk, have been established to help guide further regulatory decision making. This paper presents the personal opinions of the author as regards the use of risk today in nuclear power plant regulation, areas of further information needs, and necessary plans for moving toward a more systematic use of risk-based information in regulatory initiatives in the future

Formulating European work and employment regulation during the pre-crisis years

DEFF Research Database (Denmark)

Mailand, Mikkel; Arnholtz, Jens

2015-01-01

of Social Europe is only seen in a minority of the eight cases of EU-level work and employment regulation analysed. It is argued that two mechanisms can help explain this weaker than expected impact: successful resistance from pro-regulation actors and a certain form of organizational inertia linked...

Southern states radiological emergency response laws and regulations

International Nuclear Information System (INIS)

1990-06-01

The purpose of this report is to provide a summary of the emergency response laws and regulations in place in the various states within the southern region for use by legislators, emergency response planners, the general public and all persons concerned about the existing legal framework for emergency response. SSEB expects to periodically update the report as necessary. Radiation protection regulations without emergency response provisions are not included in the summary. The radiological emergency response laws and regulations of the Southern States Energy Compact member states are in some cases disparate. Several states have very specific laws on radiological emergency response while in others, the statutory law mentions only emergency response to ''natural disasters.'' Some states have adopted extensive regulations on the topic, others have none. For this reason, any general overview must necessarily discuss laws and regulations in general terms. State-by-state breakdowns are given for specific states

EU Regulation of Nanobiocides: Challenges in Implementing the Biocidal Product Regulation (BPR

Directory of Open Access Journals (Sweden)

Anna Brinch

2016-02-01

Full Text Available The Biocidal Products Regulation (BPR contains several provisions for nanomaterials (NMs and is the first regulation in the European Union to require specific testing and risk assessment for the NM form of a biocidal substance as a part of the information requirements. Ecotoxicological data are one of the pillars of the information requirements in the BPR, but there are currently no standard test guidelines for the ecotoxicity testing of NMs. The overall objective of this work was to investigate the implications of the introduction of nano-specific testing requirements in the BPR and to explore how these might be fulfilled in the case of copper oxide nanoparticles. While there is information and data available in the open literature that could be used to fulfill the BPR information requirements, most of the studies do not take the Organisation for Economic Co-operation and Development’s nanospecific test guidelines into consideration. This makes it difficult for companies as well as regulators to fulfill the BPR information requirements for nanomaterials. In order to enable a nanospecific risk assessment, best practices need to be developed regarding stock suspension preparation and characterization, exposure suspensions preparation, and for conducting ecotoxicological test.

EU Regulation of Nanobiocides: Challenges in Implementing the Biocidal Product Regulation (BPR).

Science.gov (United States)

Brinch, Anna; Hansen, Steffen Foss; Hartmann, Nanna B; Baun, Anders

2016-02-16

The Biocidal Products Regulation (BPR) contains several provisions for nanomaterials (NMs) and is the first regulation in the European Union to require specific testing and risk assessment for the NM form of a biocidal substance as a part of the information requirements. Ecotoxicological data are one of the pillars of the information requirements in the BPR, but there are currently no standard test guidelines for the ecotoxicity testing of NMs. The overall objective of this work was to investigate the implications of the introduction of nano-specific testing requirements in the BPR and to explore how these might be fulfilled in the case of copper oxide nanoparticles. While there is information and data available in the open literature that could be used to fulfill the BPR information requirements, most of the studies do not take the Organisation for Economic Co-operation and Development's nanospecific test guidelines into consideration. This makes it difficult for companies as well as regulators to fulfill the BPR information requirements for nanomaterials. In order to enable a nanospecific risk assessment, best practices need to be developed regarding stock suspension preparation and characterization, exposure suspensions preparation, and for conducting ecotoxicological test.

Self trust, a major challenge for nuclear regulators

Energy Technology Data Exchange (ETDEWEB)

Eibenschutz, J. [National Nuclear Safety and Safeguards Commission (CNSN), Mexico City (Mexico)

2014-07-01

Self trust. The nuclear community and particularly nuclear regulators overreact to accidents, this has been the case with the three NPP major accidents. Lowering admissible radiation levels, for example, conveys the wrong message to politicians and the general public, and contributes to enhance mistrust towards nuclear. Industry as well as regulators should mature and act with self respect, since the scientific bases of regulation are very solid and should be trusted. Lessons learned should be seriously pursued in spite of the 'uneven playing field'. Obviously safety continues as the main priority, but paranoid reactions from the nuclear professionals could destroy the future of nuclear power. (author)

Self trust, a major challenge for nuclear regulators

International Nuclear Information System (INIS)

Eibenschutz, J.

2014-01-01

Self trust. The nuclear community and particularly nuclear regulators overreact to accidents, this has been the case with the three NPP major accidents. Lowering admissible radiation levels, for example, conveys the wrong message to politicians and the general public, and contributes to enhance mistrust towards nuclear. Industry as well as regulators should mature and act with self respect, since the scientific bases of regulation are very solid and should be trusted. Lessons learned should be seriously pursued in spite of the 'uneven playing field'. Obviously safety continues as the main priority, but paranoid reactions from the nuclear professionals could destroy the future of nuclear power. (author)

Development in the Regulation of Wages and Working Conditions

DEFF Research Database (Denmark)

Høgedahl, Laust Kristian; Jørgensen, Henning

2017-01-01

The Nordic countries are renowned for their high level of unionization and collective bargaining. However, globalization, Europeanization, and an increasing individualization are often pictured as factors suppressing collective regulation. In this article, we look at the developments in the regul...... and in employee awareness, but Danish wage and salary earners also have an interest in extra support in the form of generalization and/or a politically regulated minimum wage....... in the regulation of wages and working conditions from a macro perspective by combing two large crosssectional surveys into a longitudinal study with point of departure in the Danish case. We find that collective bargaining coverage continues to stand surprisingly strong, both in terms of being very widespread...

Distributed resources and re-regulated electricity markets

International Nuclear Information System (INIS)

Ackermann, Thomas

2007-01-01

This paper briefly defines distributed resources (DR) and discusses the current status of DR. The main focus is on discussing the value DR can provide to re-regulated electricity markets. DR can, under certain circumstances, help to significantly reduce the main problem of re-regulation, i.e. market power. Distributed generation and demand-side resources may, even if only small quantities in terms of size of the entire market are utilised, be able to help to significantly reduce market power. This results in a significantly more efficient market. To achieve such benefits, however, DR must be in operation during times when market power issues are likely to arise. To a certain extent this is the case as demand-side resources are usually independent of established generation companies. In addition, many business cases for DG require DG to actually operate to capture the second revenue. (author)

Using consensus building to improve utility regulation

International Nuclear Information System (INIS)

Raab, J.

1994-01-01

The utility industry and its regulatory environment are at a crossroads. Utilities, intervenors and even public utility commissions are no longer able to initiate and sustain changes unilaterally. Traditional approaches to regulation are often contentious and costly, producing results that are not perceived as legitimate or practical. Consensus building and alternative dispute resolution have the potential to help utilities, intervenors and regulators resolve a host of regulatory issues. This book traces the decline of consensus in utility regulation and delineates current controversies. It presents the theory and practice of alternative dispute resolution in utility regulation and offers a framework for evaluating the successes and failures of attempts to employ these processes. Four regulatory cases are analyzed in detail: the Pilgrim nuclear power plant outage settlement, the use of DSM collaboratives, the New Jersey resource bidding policy and the formation of integrated resource management rules in Massachusetts

Naked regulators: moral pluralism, deliberative democracy and authoritative regulation of human embryonic stem cell (hESC) research.

Science.gov (United States)

Parker, Malcolm

2009-02-01

Bioethical issues pose challenges for pluralist, democratic societies due to the need to arbitrate between incompatible views over fundamental beliefs. The legitimacy of public policy is increasingly seen to depend on taking public consultation seriously, and subsequently regulating contested activities such as therapeutic cloning and hESC research. In December 2006, the Australian Federal Parliament lifted the ban on therapeutic cloning, following recommendations of the Legislation Review Committee (Lockhart Committee), which recently reported on its approach and methods in this journal. This column analyses recent accounts of democratic deliberative processes, authoritative regulation and the committee's own account. Authoritative regulation turns out to be largely an appeasement strategy, directed towards the losers of the contest, in this case the opponents of therapeutic cloning and hESC research. This is because regulation fails to minimise harm as perceived by the losers, and fails to meaningfully limit what it is the winners wish to do. Moreover, regulation adds an unnecessary layer of red tape to the work of the winners. Committees of inquiry in bioethical matters should be more open about their processes and their normative recommendations, at the risk of eroding trust in parts of their processes.

75 FR 65439 - Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting System

Science.gov (United States)

2010-10-25

... Accounting Service or Missile Defense Agency. (2) For DoD, the authority to acknowledge receipt or reject... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 219 and 252 [DFARS Case 2009-D002] Defense Federal Acquisition Regulation Supplement; Electronic Subcontracting Reporting...

Legislation for the countermeasures on special issues of nuclear safety regulations

International Nuclear Information System (INIS)

Cho, Byung Sun; Lee, Mo Sung; Chung, Gum Chun; Kim, Hak Man; Oh, Ho Chul

2003-02-01

Since the present legal system on nuclear safety regulation has some problems that refer to contents of regulatory provisions, this mid-report has preformed research on the legal basic theory of nuclear safety regulation. And then secondly this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation. In order to interpret easily this report finally took the cases of judicial precedents on nuclear safety regulation in USA, Germany, Japan and Korea

Legislation for the countermeasures on special issues of nuclear safety regulations

Energy Technology Data Exchange (ETDEWEB)

Cho, Byung Sun; Lee, Mo Sung; Chung, Gum Chun; Kim, Hak Man; Oh, Ho Chul [Chongju Univ., Cheongju (Korea, Republic of)

2003-02-15

Since the present legal system on nuclear safety regulation has some problems that refer to contents of regulatory provisions, this mid-report has preformed research on the legal basic theory of nuclear safety regulation. And then secondly this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation. In order to interpret easily this report finally took the cases of judicial precedents on nuclear safety regulation in USA, Germany, Japan and Korea.

Enhancing forest tenure reforms through more responsive regulations

Directory of Open Access Journals (Sweden)

Anne M Larson

2012-01-01

Full Text Available Forest tenure reforms have offered new opportunities for communities to obtain formal rights to forests and forest benefits, but at the same time a variety of limitations are placed on livelihood options. This article draws on several case studies of reforms in Africa, Asia and Latin America to analyse the regulations accompanying reforms. It identifies three types of regulations, namely rules that limit areas available to local communities; rules that delineate conservation areas and impose related limits on use; and bureaucratic requirements for permits and management plans, which restrict the commercial use and marketing of valuable forest products. It discusses problems with these regulations, and proposes a simple framework for identifying ways to promote regulations that work for forest conservation but are more responsive to the needs of communities and forests.

Assisted suicide: Models of legal regulation in selected European countries and the case law of the European Court of Human Rights.

Science.gov (United States)

Grosse, Claudia; Grosse, Alexandra

2015-10-01

This paper presents three different models of the legal regulation of assisted suicide in European countries. First, the current legal regime governing assisted suicide in the Netherlands is described where both euthanasia and assisted suicide have been legalised. This section also includes some empirical data on euthanasia and assisted-suicide practices in the Netherlands, as well as a comparison with the current legal legislation in Belgium and Luxembourg. Next, Switzerland is presented as a country where euthanasia is punishable by law but assisted suicide is legally allowed, provided it is not carried out with selfish motives. This section also focuses on the assisted-suicide-related case law of the Swiss Federal Supreme Court and the European Court of Human Rights. Last, the current legal situation regarding assisted suicide in Austria and Germany is described. While the Austrian Penal Code explicitly prohibits assisted suicide, assistance with suicide is not specifically regulated by the German Penal Code. However, medical doctors are not allowed to assist suicides according to the professional codes of conduct drawn up by the German medical associations under the supervision of the health authorities. © The Author(s) 2014.

Environmental Regulation and Food Safety: Studies of Protection ...

International Development Research Centre (IDRC) Digital Library (Canada)

2006-01-01

Jan 1, 2006 ... Book cover Environmental Regulation and Food Safety: Studies of ... are sometimes perceived in developing countries as nontariff barriers to trade. ... In some cases, products that had initially been refused access to a ...

FOOD SAFETY REGULATIONS BASED ON REAL SCIENCE

Directory of Open Access Journals (Sweden)

Huub LELIEVELD

2015-10-01

Full Text Available Differences in regulations result in needless destruction of safe food and hamper food trade. The differences are not just the result of the history of food safety regulations, often developed in times before global cooperation, but are also built in new regulations. It may be responses to media hypes or for other reasons, but in most cases the differences cannot be justified scientifically. A major difficulty is that, due to the developments in analytical techniques the number of chemicals that are found in food is increasing rapidly and chemicals are always suspected to be a safety risk. By far most chemicals are of natural origin but could not be detected in the past because the methods available in the past were not sensitive enough. Demanding the absence of chemicals because the risk they present is unknown, however, would eventually make all food unacceptable. The general public should be shown that everything they eat is chemical, and all food components will be toxic if the amount is too high. It should also be shown that many of these chemicals will also cause illness and death if there is not enough of it as is the case with vitamins and minerals.

The Legal Structure of Commercial Banks and Financial Regulation : does organizational form matter for the design of bank regulation?

NARCIS (Netherlands)

V.L.E. Cedeno-Brea (Enmanuel)

2017-01-01

markdownabstractDo the different ways that commercial banks are legally organized matter for the design of financial regulation? It is often assumed that most commercial banks are setup as investor owned business corporations. However, this is not always the case In many jurisdictions, banks are

Observations of a Working Class Family: Implications for Self-Regulated Learning Development

Science.gov (United States)

Vassallo, Stephen

2012-01-01

Guardians have been implicated in the development of children's academic self-regulation. In this case study, which involved naturalistic observations and interviews, the everyday practices of a working class family were considered in the context of self-regulated learning development. The family's practices, beliefs, dispositions and home…

Regulation of the Output Voltage of an Inverter in Case of Load Variation

Science.gov (United States)

Diouri, Omar; Errahimi, Fatima; Es-Sbai, Najia

2018-05-01

In a DC/AC photovoltaic application, the stability of the output voltage of the inverter plays a very important role in the electrical systems. Such a photovoltaic system is constituted by an inverter, which makes it possible to convert the continuous energy to the alternative energy used in systems which operate under a voltage of 230V. The output of this inverter can be connected to a single load or more, at which time a second load is added in parallel with the first load. In this case, it proves a voltage drop at the output of the inverter. This problem influences the proper functioning of the electrical loads. Therefore, our contribution is to give a solution to this by compensating this voltage drop using a boost converter at the input of the inverter. This boost converter will play the role of the compensator that will provide the necessary voltage to the inverter in order to increase the voltage across the loads. But the use of this boost without controlling it is not enough because it generates a voltage that depends on the duty cycle of the control signal. To stabilize the output voltage of the inverter, we used a Proportional, Integral, and Derivative control (PID), which makes it possible to generate the necessary control signal for the voltage boost in order to have a good regulation of the output voltage of the inverter. Finally, we have solved the problem of the voltage drop even though there is loads variation.

75 FR 75549 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

Science.gov (United States)

2010-12-03

..., et al. Defense Federal Acquisition Regulation Supplement; Business Systems-- Definition and... Regulation Supplement; Business Systems--Definition and Administration (DFARS Case 2009-D038) AGENCY: Defense.... SUPPLEMENTARY INFORMATION: I. Background DoD published a proposed rule for Business Systems--Definition and...

Frequent down-regulation of ABC transporter genes in prostate cancer

International Nuclear Information System (INIS)

Demidenko, Rita; Razanauskas, Deividas; Daniunaite, Kristina; Lazutka, Juozas Rimantas; Jankevicius, Feliksas; Jarmalaite, Sonata

2015-01-01

ATP-binding cassette (ABC) transporters are transmembrane proteins responsible for the efflux of a wide variety of substrates, including steroid metabolites, through the cellular membranes. For better characterization of the role of ABC transporters in prostate cancer (PCa) development, the profile of ABC transporter gene expression was analyzed in PCa and noncancerous prostate tissues (NPT). TaqMan Low Density Array (TLDA) human ABC transporter plates were used for the gene expression profiling in 10 PCa and 6 NPT specimens. ABCB1 transcript level was evaluated in a larger set of PCa cases (N = 78) and NPT (N = 15) by real-time PCR, the same PCa cases were assessed for the gene promoter hypermethylation by methylation-specific PCR. Expression of eight ABC transporter genes (ABCA8, ABCB1, ABCC6, ABCC9, ABCC10, ABCD2, ABCG2, and ABCG4) was significantly down-regulated in PCa as compared to NPT, and only two genes (ABCC4 and ABCG1) were up-regulated. Down-regulation of ABC transporter genes was prevalent in the TMPRSS2-ERG-negative cases. A detailed analysis of ABCB1 expression confirmed TLDA results: a reduced level of the transcript was identified in PCa in comparison to NPT (p = 0.048). Moreover, the TMPRSS2-ERG-negative PCa cases showed significantly lower expression of ABCB1 in comparison to NPT (p = 0.003) or the fusion-positive tumors (p = 0.002). Promoter methylation of ABCB1 predominantly occurred in PCa and was rarely detected in NPT (p < 0.001). The study suggests frequent down-regulation of the ABC transporter genes in PCa, especially in the TMPRSS2-ERG-negative tumors. The online version of this article (doi:10.1186/s12885-015-1689-8) contains supplementary material, which is available to authorized users

Environmental regulation in a network of simulated microbial ecosystems

OpenAIRE

Williams, Hywel T. P.; Lenton, Timothy M.

2008-01-01

The Earth possesses a number of regulatory feedback mechanisms involving life. In the absence of a population of competing biospheres, it has proved hard to find a robust evolutionary mechanism that would generate environmental regulation. It has been suggested that regulation must require altruistic environmental alterations by organisms and, therefore, would be evolutionarily unstable. This need not be the case if organisms alter the environment as a selectively neutral by-product of their ...

Natural gas transport, regulation in UK

International Nuclear Information System (INIS)

Goldoni, Giovanni

2005-01-01

The detailed analysis contained in this case history demonstrates the great efforts made in the field of incentive regulation in order to promote competition in the gas market and to improve the efficiency of the gas transport system. The next challenge will be to preserve competition and efficiency in a quite different gas-supply condition [it

Short-term regulation of hydro powerplants. Studies on the environmental effects

International Nuclear Information System (INIS)

Sinisalmi, T.; Riihimaeki, J.; Vehanen, T.; Yrjaenae, T.

1997-01-01

The publication is a final report on a project studying effects of short-term regulation of hydro power plants. The project consists of two parts: (1) examining and developing methods for evaluation, (2) applying methods in a case study at the Oulujoki River. The economic value of short-term regulation was studied with a model consisting of an optimization model and a river simulation model. Constraints on water level or discharge variations could be given to the power plants and their economical influence could be studied. Effects on shoreline recreation use due to water level fluctuation were studied with a model where various effects are made commensurable and expressed in monetary terms. A literature survey and field experiments were used to study the methods for assessing effects of short-term regulation on river habitats. The state and development needs of fish stocks and fisheries in large regulated rivers were studied and an environmental classification was made. Remedial measures for the short-term regulated rivers were studied with a literature survey and enquiries. A comprehensive picture of the various effects of short-term regulation was gained in the case study in Oulujoki River (110 km long, 7 power plants). Harmful effects can be reduced with the given recommendations of remedial measures on environment and the usage of the hydro power plants. (orig.) 52 refs

Short-term regulation of hydro powerplants. Studies on the environmental effects

Energy Technology Data Exchange (ETDEWEB)

Sinisalmi, T. [ed.; Forsius, J.; Muotka, J.; Soimakallio, H. [Imatran Voima Oy, Vantaa (Finland); Riihimaeki, J. [VTT, Espoo (Finland); Vehanen, T. [Finnish Game and Fisheries Research Inst. (Finland); Yrjaenae, T. [North Ostrobothnia Regional Environmental Centre, Oulu (Finland)

1997-12-31

The publication is a final report on a project studying effects of short-term regulation of hydro power plants. The project consists of two parts: (1) examining and developing methods for evaluation, (2) applying methods in a case study at the Oulujoki River. The economic value of short-term regulation was studied with a model consisting of an optimization model and a river simulation model. Constraints on water level or discharge variations could be given to the power plants and their economical influence could be studied. Effects on shoreline recreation use due to water level fluctuation were studied with a model where various effects are made commensurable and expressed in monetary terms. A literature survey and field experiments were used to study the methods for assessing effects of short-term regulation on river habitats. The state and development needs of fish stocks and fisheries in large regulated rivers were studied and an environmental classification was made. Remedial measures for the short-term regulated rivers were studied with a literature survey and enquiries. A comprehensive picture of the various effects of short-term regulation was gained in the case study in Oulujoki River (110 km long, 7 power plants). Harmful effects can be reduced with the given recommendations of remedial measures on environment and the usage of the hydro power plants. (orig.) 52 refs.

Communicating EU-regulated matters in the blogosphere

DEFF Research Database (Denmark)

Agerdal-Hjermind, Annette; Valentini, Chiara

The aim of this paper is to explore the role of blogging as a communication strategy for communicating regulations by looking at a specific case of a Danish government agency, the Patent and Trademark Office (DKPTO) , and its blogging activities towards external publics and with the purpose of ag...

Noise-induced multistability in the regulation of cancer by genes and pseudogenes

Energy Technology Data Exchange (ETDEWEB)

Petrosyan, K. G., E-mail: pkaren@phys.sinica.edu.tw [Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan (China); Hu, Chin-Kun, E-mail: huck@phys.sinica.edu.tw [Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan (China); National Center for Theoretical Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan (China); Business School, University of Shanghai for Science and Technology, Shanghai 200093 (China)

2016-07-28

We extend a previously introduced model of stochastic gene regulation of cancer to a nonlinear case having both gene and pseudogene messenger RNAs (mRNAs) self-regulated. The model consists of stochastic Boolean genetic elements and possesses noise-induced multistability (multimodality). We obtain analytical expressions for probabilities for the case of constant but finite number of microRNA molecules which act as a noise source for the competing gene and pseudogene mRNAs. The probability distribution functions display both the global bistability regime as well as even-odd number oscillations for a certain range of model parameters. Statistical characteristics of the mRNA’s level fluctuations are evaluated. The obtained results of the extended model advance our understanding of the process of stochastic gene and pseudogene expressions that is crucial in regulation of cancer.

75 FR 33237 - Defense Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS...

Science.gov (United States)

2010-06-11

... Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS Case 2009-D025) AGENCY: Defense.../Pension Review from Procedures, Guidance, and Information to the Defense Acquisition Regulation Supplement..., February 23, 2006, moved requirements for Contractor Insurance/Pension Review (CIPR) from DFARS 242.7302 to...

Monitoring of Dips in the MV Network for Regulation- A Case Study

NARCIS (Netherlands)

Weldemariam, L.E.; Cuk, V.; Cobben, J.F.G.; Kling, W.L.

2014-01-01

Abstract— Voltage dips constitute to a noticeable part of power quality (PQ) problems but causing major financial losses to industrial and commercial customers. This work involves comparative studies to choose the most appropriate location of monitoring dips for regulation. In this paper, a Dutch MV

Exploration economics in a regulated petroleum province: The case of the Norwegian Continental Shelf

International Nuclear Information System (INIS)

Mohn, Klaus; Osmundsen, Petter

2008-01-01

Reserve replacement remains a key challenge for the international oil and gas companies. As market-oriented oil and gas provinces are maturing, exploration activity is shifted towards the resource-rich, regulated regimes outside the OECD. Regulated oil and gas provinces remain under-explored also in econometric terms. In this paper, we specify and estimate an econometric model of exploration and appraisal drilling for the highly regulated Norwegian Continental Shelf (NCS) over the period 1965 to 2004. Explanatory variables include the oil price, cumulative discoveries and open exploration acreage. Estimated error-correction models account explicitly for sluggishness and short-term adjustments in exploration drilling. We find robust long-term oil price effects on exploration activity, whereas the short-term response is muted. On the other hand, the temporary influence on exploration drilling from licensing rounds for new exploration acreage is significant, and so are the feedback effects from historical exploration success. At the same time, the longer-term impact of these variables is more moderate. (author)

Association between regulator of telomere elongation helicase1 (RTEL1) gene and HAPE risk: A case-control study.

Science.gov (United States)

Rong, Hao; He, Xue; Zhu, Linhao; Zhu, Xikai; Kang, Longli; Wang, Li; He, Yongjun; Yuan, Dongya; Jin, Tianbo

2017-09-01

High altitude pulmonary edema (HAPE) is a paradigm of pulmonary edema. Mutations in regulator of telomere elongation helicase1 (RTEL1) represent an important contributor to risk for pulmonary fibrosis. However, little information is found about the association between RTEL1 and HAPE risk. The present study was undertaken to tentatively explore the potential relation between single-nucleotide polymorphisms (SNPs) in RTEL1 and HAPE risk in Chinese Han population. A total of 265 HAPE patients and 303 healthy controls were included in our case-control study. Four SNPs in RTEL1 were selected and genotyped using the Sequenom MassARRAY method. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by unconditional logistic regression with adjustment for gender and age. All P values were Bonferroni corrected, and statistical significance was set at P RTEL1 and a decreased risk HAPE in the Chinese population. The results need further confirmation.

Environmental regulation of a power investment in an international market

International Nuclear Information System (INIS)

Vennemo, H.; Halseth, A.

2001-01-01

We examine the optimal environmental regulation of three Norwegian power projects: energy conservation, a natural gas fired CCGT and a new hydro project. All projects reduce emissions elsewhere in the Nordic region, and the environmental costs of these emissions are not, in general, fully reflected in market prices. We develop a theory of second best optimal regulation for this case. The optimal regulation is found to deviate substantially from a purely domestic regulation. For instance, we find it optimal to grant a substantial credit to energy conservation. The credit is sensitive to the value of reduced CO 2 emissions and whether the current Norwegian end user tax should be interpreted as an environmental or a fiscal tax

Green spaces are not all the same for the provision of air purification and climate regulation services: The case of urban parks.

Science.gov (United States)

Vieira, Joana; Matos, Paula; Mexia, Teresa; Silva, Patrícia; Lopes, Nuno; Freitas, Catarina; Correia, Otília; Santos-Reis, Margarida; Branquinho, Cristina; Pinho, Pedro

2018-01-01

The growing human population concentrated in urban areas lead to the increase of road traffic and artificial areas, consequently enhancing air pollution and urban heat island effects, among others. These environmental changes affect citizen's health, causing a high number of premature deaths, with considerable social and economic costs. Nature-based solutions are essential to ameliorate those impacts in urban areas. While the mere presence of urban green spaces is pointed as an overarching solution, the relative importance of specific vegetation structure, composition and management to improve the ecosystem services of air purification and climate regulation are overlooked. This avoids the establishment of optimized planning and management procedures for urban green spaces with high spatial resolution and detail. Our aim was to understand the relative contribution of vegetation structure, composition and management for the provision of ecosystem services of air purification and climate regulation in urban green spaces, in particular the case of urban parks. This work was done in a large urban park with different types of vegetation surrounded by urban areas. As indicators of microclimatic effects and of air pollution levels we selected different metrics: lichen diversity and pollutants accumulation in lichens. Among lichen diversity, functional traits related to nutrient and water requirements were used as surrogates of the capacity of vegetation to filter air pollution and to regulate climate, and provide air purification and climate regulation ecosystem services, respectively. This was also obtained with very high spatial resolution which allows detailed spatial planning for optimization of ecosystem services. We found that vegetation type characterized by a more complex structure (trees, shrubs and herbaceous layers) and by the absence of management (pruning, irrigation and fertilization) had a higher capacity to provide the ecosystems services of air

Regulator preferences and utility prices: evidence from natural gas distribution utilities

International Nuclear Information System (INIS)

Klein, C.C.; Sweeney, G.H.

1999-01-01

We investigate the determinants of regulators' relative weighting of the social welfare of customer groups and utilities using panel data on natural gas distribution utilities in the US state of Tennessee. In contrast to previous empirical work on cross-sections of electric utilities, our results are statistically robust and consistent with the interest group theory of regulation. Intervention in rate cases, settlement vs. litigation of cases, and prices of alternative energy sources, as well as the size characteristics of customer groups and the firm, are significant determinants of the elasticity-weighted price-cost margin (Ramsey number) for each group. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

Offshore regulators focus on incentives for safety

Energy Technology Data Exchange (ETDEWEB)

Reid, W.

2000-11-27

Strict safety regulations in effect at offshore drilling sites are discussed. The guiding principle in all existing regulation is that while economic or industrial considerations are important, the value and the concern for human life is paramount. Should some tragic event occur at an offshore drilling site that is shown to have been caused by negligence of an operator, there is no question at all that the regulatory authority, in this case the Canada-Newfoundland Offshore Petroleum Board (CNOPB), would take the negligent operator to court. Nevertheless, Canadian authorities remain confident that encouragement of maintaining a safe working environment is likely to be more successful in ensuring workplace safety than threats of punishment. Indeed, Canadian regulators have, in recent times, shown a tendency to move towards performance-based systems, as opposed to the more usual prescriptive or rule-bound regulatory regime. This new approach involves setting targets and giving companies the responsibility to implement measures to reach the targets rather than relying on government instructions. Still, performance-based regulation in Canada is relatively new and some regulations remain prescriptive. Examples are the requirement for two immersion suits and two lifeboat seats for every worker on a drilling unit.

Network regulation and regulatory institutional reform: Revisiting the case of Australia

International Nuclear Information System (INIS)

Nepal, Rabindra; Menezes, Flavio; Jamasb, Tooraj

2014-01-01

It is well-understood that the success of liberalizing the electricity supply industry depends crucially on the quality and design of the regulatory and institutional framework. This paper analyses the regulatory arrangements that underpin the work of the Australian Energy Regulator (AER). These arrangements are contrasted with the regulatory structure of electricity provision in Norway. A key difference between the reform processes in the two countries relates to the lack of privatization in Norway and the co-existence of private and publicly owned generators and distributors in Australia. This comparative analysis allows us to make several recommendations to improve regulatory arrangements in Australia. These include greater independence for the AER, better coordination among regulatory institutions, greater use of benchmarking analysis, greater customer involvement, and improving market transparency and privatization of government-owned corporations. However, the success of privatization will hinge upon the effectiveness of the regulatory environment. - Highlights: • Rising electricity prices and network costs is of great concern in Australia. • Flaws in the existing regulatory environment and economic efficiency exist. • The AER should be provided with adequate resources (financial and staff experts) and discretion. • Robust benchmarking techniques should be adopted in the incentive regulation framework for cost efficiency. • Privatization of the state-owned assets also remains an option

Climate Regulation Services of Natural and Managed Ecosystems of the Americas

Science.gov (United States)

Anderson-Teixeira, K. J.; Snyder, P. K.; Twine, T. E.; Costa, M. H.; Cuadra, S.; DeLucia, E. H.

2011-12-01

Terrestrial ecosystems regulate climate through both biogeochemical mechanisms (greenhouse gas regulation) and biophysical mechanisms (regulation of water and energy). Land management therefore provides some of the most effective strategies for climate change mitigation. However, most policies aimed at climate protection through land management, including UNFCCC mechanisms and bioenergy sustainability standards, account only for biogeochemical climate services. By ignoring biophysical climate regulation services that in some cases offset the biogeochemical regulation services, these policies run the risk of failing to advance the best climate solutions. Quantifying the combined value of biogeochemical and biophysical climate regulation services remains an important challenge. Here, we use a combination of data synthesis and modeling to quantify how biogeochemical and biophysical effects combine to shape the climate regulation value (CRV) of 18 natural and managed ecosystem types across the Western Hemisphere. Natural ecosystems generally had higher CRVs than agroecosystems, largely driven by differences in biogeochemical services. Biophysical contributions ranged from minimal to dominant. They were highly variable in space and across ecosystem types, and their relative importance varied strongly with the spatio-temporal scale of analysis. Our findings pertain to current efforts to protect climate through land management. Specifically, they reinforce the importance of protecting tropical forests and recent findings that the climatic effects of bioenergy production may be somewhat more positive than previously estimated. Given that biophysical effects in some cases dominate, ensuring effective climate protection through land management requires consideration of combined biogeochemical and biophysical climate regulation services. While quantification of ecosystem climate services is necessarily complex, our CRV index serves as one potential approach to measure the

JURIDICAL REGIME OF THE INTEREST IN THE ROMANIAN LAW. PARTICULAR CASE. COMPARISON BETWEEN THE REGULATIONS OF THE REMUNERATORY INTEREST VERSUS THE PENALIZING INTEREST, IN THE ROMANIAN BANKING LAW

Directory of Open Access Journals (Sweden)

Silvia Lucia Cristea

2015-11-01

Full Text Available The analysis of a case where the rate of the conventional interest is not specified made me investigate what is the maximal limit that can be obtained in this case, under the regulation in force, in the Romanian law (sect.1!To formulate a solution, I considered as necessary to analyze : the provision on the moratory damages (according to the Roman Civil Code and the putting of the debtor in default, in order to know what is the date starting from which the moratory damages are calculated (according to the Roman Civil Code-sect.2; the juridical regime of the interest (according to the Roman Bankin Law-sect.3;comparison between the remuneratory interest and the penalizing interest (according to the Roman Banking Law-sect.4;solution for the case and conclusions-sect. 5.

(Mis)regulation--the case of commercial surrogacy.

Science.gov (United States)

Mahajan, Tarang

2015-01-01

In the most recent attempt to regulate commercial surrogacy, the Ministry of Home Affairs (MHA) has issued a notice altering the category of visa for foreign nationals entering into commercial surrogacy arrangements from "tourist" to "medical". Upon close scrutiny, it becomes clear that this measure is a far too hasty and unprincipled step. Given the varying laws across different countries, commercial surrogacy has been an area marked by a fair amount of legal ambiguity and conflict, for example, with respect to the citizenship status of the child and legally accepted parentage of commissioning parents. The MHA's step towards addressing some of the dilemmas is, however, grossly inadequate and discriminatory. In spite of its seeming advantages, of some administrative and legal oversight of the industry, the notice will impact the existing practices in questionable ways since its provisions remain to be vetted through the lens of medical ethics and social justice. The measures, which are supposed to ensure legality, disambiguation and some degree of security for the commercial surrogate, end up giving a clean chit to the industry for the time being. If the step taken by the MHA was meant to be urgent, one wonders at the lack of motivation to strengthen public debate and produce a piece of legislation that can address the various concerns and dilemmas generated by the assisted reproductive technologies (ARTs). This is especially with reference to legislation that ensures the health and democratic rights of those who are at a disadvantage due to the power imbalance in commercial surrogacy arrangements.

Alternative development and action plan for the atomic safety regulation instruments

International Nuclear Information System (INIS)

Kim, J. Y.; Ahn, S. K.; Ham, Y. S.

2004-01-01

The goal of this study to provide highly practical model to regulation agency. Since nuclear power safety regulation has different characteristics, compared to general regulation, it is important to have new point of view and approach. But application possibility for regulation that guarantees the 'perfect safety' is very low. Therefore, it is important establish nuclear power safety regulation that is realistic as well as safety securing. In order to establish high quality regulation, evaluation of existing regulation must be done first. Thus in this study, 6 standards to evaluate existing regulation are suggested. They are clearness, efficiency, flexibility, reliability, responsibility and political consideration. Also, strategies to complement the weak points of regulatory governance, regulatory sunset, regulatory map, regulatory negotiation, regulatory benefit cost analysis, etc. These strategies can be applied all in one regulation, and can strategically be selected for application. After analyzing the result if case analysis on nuclear furnace regulation for research study, agreement was made that it is most efficient to consider in the order if clearness reliability, flexibility, confidence, political consideration, administrative efficiency and economic efficiency

Swan Queen, shipping, and boundary regulation in fandom

Directory of Open Access Journals (Sweden)

Victoria M. Gonzalez

2016-09-01

Full Text Available There are a number of fan activities and practices that are subject to regulation. The mechanisms of regulation in shipping, however, are not always clear. Shipping, the fan activity of romantically pairing two fictional characters, has become a popular and contentious facet of fan interaction. The case that will be examined in this article is that of the Swan Queen ship, which pairs two female characters from Once Upon a Time (2011–. The lengths that fans have gone to support and promote this ship led to rather intense discussion and infighting among members of the Once Upon a Time fandom. I utilize comments and posts made on Tumblr to examine the mechanisms that dictate inclusion and exclusion in shipper communities. In doing so, I hope to identify the kinds of shipper activities that are subject to regulation and the kinds of boundaries that this regulation establishes. Shipping is dictated not only by fans' imaginations but also by boundaries that are performed and regulated on digital forums.

Insulin resistance in human subjects having impaired glucose regulation

International Nuclear Information System (INIS)

Khan, S.H.; Khan, F.A.; Ijaz, A.

2007-01-01

To determine insulin resistance in human subjects having impaired glucose regulation (IGR) by Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). A total of 100 subjects with impaired glucose regulation were selected for evaluation of metabolic syndrome as per the criteria of National Cholesterol Education Program, Adult Treatment Panel III (NCEP, ATP III), along with 47 healthy age and gender-matched controls. Physical examination to determine blood pressure and waist circumference was carried out and so was sampling for plasma glucose, serum triglycerides, HDL-cholesterol and insulin. Insulin resistance was calculated by the HOMA-IR. Finally, subjects with and without metabolic syndrome were compared with controls (n=47), using one-way ANOVA for studying insulin resistance between groups, with Tukey's post-hoc comparison. The frequency of finding metabolic syndrome in cases of IGR remained 47%. The insulin resistance demonstrated stepwise worsening from control population (mean=1.54, 95 % CI: 1.77 - 2.37) to subjects suffering from only IGR (mean=2.07, 95 % CI: 1.77- 2.37) to metabolic syndrome (mean=2.67, 95 %, CI: 2.34 - 3.00) (p < 0.001). Patients with impaired glucose regulation may have significant insulin resistance. It is, thus, recommended that a vigorous search be made to measure insulin resistance in all cases diagnosed to have impaired glucose regulation. (author)

Membrane-bound transcription factors: regulated release by RIP or RUP.

Science.gov (United States)

Hoppe, T; Rape, M; Jentsch, S

2001-06-01

Regulated nuclear transport of transcription factors from cytoplasmic pools is a major route by which eukaryotes control gene expression. Exquisite examples are transcription factors that are kept in a dormant state in the cytosol by membrane anchors; such proteins are released from membranes by proteolytic cleavage, which enables these transcription factors to enter the nucleus. Cleavage can be mediated either by regulated intramembrane proteolysis (RIP) catalysed by specific membrane-bound proteases or by regulated ubiquitin/proteasome-dependent processing (RUP). In both cases processing can be controlled by cues that originate at or in the vicinity of the membrane.

75 FR 19345 - Federal Acquisition Regulation; FAR Case 2009-006, Labor Relations Costs

Science.gov (United States)

2010-04-14

... manner of exercising, the right to organize and bargain collectively through representatives of the... submit comments only and cite FAR case 2009- 006, in all correspondence related to this case. All... publication schedules, contact the Regulatory Secretariat at (202) 501-4755. Please cite FAR case 2009- 006...

Connectivity analysis of suggestive brain areas involved in middle ear pressure regulation in humans

DEFF Research Database (Denmark)

SA, Sami; Gaihede, Michael

2010-01-01

, MEP counter-regulation presented as Eustachian tube openings with steep and fast pressure changes toward 0 Pa, whereas in others, gradual and slow pressure changes presented related to the mastoid; these changes sometimes crossed 0 Pa into opposite pressures. In many cases, combinations...... to continuous regulation of smaller pressures, whereas the tube was related to intermittent regulation of higher pressures....

The Characteristics of an Effective Nuclear Regulator

International Nuclear Information System (INIS)

Cheok, Michael; Wertelaers, An; Lojk, Robert; Santini, Miguel; Alm-Lytz, Kirsi; Rigail, Anne-Cecile; Weidenbruck, Kai-Jochen; Stoppa, Gisela; Rainieri, Roberto; Aoki, Masahiro; Gonzalez-Mercado; Miroshnichenko, Mikhail; Kuznetsov, Nikolay; Kudryavtsev, Evgeny; Cid, Rafael; Franzen, Anna; Skanberg, Lars; Gibson, Steve; Golshan, Mina; Cheok, Michael; Nicic, Adriana; Salgado, Nancy; Creswell, Len

2014-01-01

Both national and international organisations agree that the fundamental objective of all nuclear safety regulatory bodies - the regulator's prime purpose - is to ensure that nuclear licensees operate their facilities at all times in a safe manner. Much has been written about ways to improve regulatory processes or to improve the effectiveness of a regulatory body, including in previous OECD/NEA regulatory guidance booklets. But until now, none have focused on the characteristics of an effective nuclear safety regulator. Effective organisations are those that have good leadership and are able to transform strategic direction into operational programmes. Effectiveness is about how well the organisation is achieving its fundamental purpose - in the case of a nuclear safety regulator, ensuring that licensees operate their facilities and discharge their obligations in a safe manner. This regulatory guidance booklet describes the characteristics of an effective nuclear safety regulator in terms of roles and responsibilities, principles and attributes. Each of the characteristics discussed in this report is a necessary feature of an effective nuclear safety regulator but no one characteristic is sufficient on its own. It is the combination of these characteristics that leads to the effectiveness of a nuclear regulatory body. The report provides a unique resource to countries with existing, mature regulators and can be used for benchmarking as well as training and developing staff. It will also be useful for new entrant countries in the process of developing and maintaining an effective nuclear safety regulator. (authors)

A case of psychosis after use of a detoxification kit and a review of techniques, risks, and regulations associated with the subversion of urine drug tests.

Science.gov (United States)

Mittal, Moneeshindra Singh; Kalia, Rachna; Khan, Ahsan Y

2011-01-01

The practice of drug testing in the workplace has been adopted for US federal government employees, and many state and local governments as well as private businesses have followed suit. However, a parallel industry dedicated to subverting the results of urine drug testing has emerged with little or no regulation. First, the case of a 19-year-old man who developed psychosis after the use of a detoxification kit is presented. Second, a review of the existing literature on the techniques, risks, and regulations associated with the use of drug tampering kits is provided. PubMed, Cochrane Database, and Google Scholar were searched using the keywords UDS, urine toxicology, pass the drug test, and clean UA, with no restrictions on publication date. Case reports, letters to the editor, and original research and review articles in multiple languages were reviewed, as were federal regulations and acts on the topic. The search yielded 4,082 results, of which 49 articles were selected for relevance. Some articles were later omitted as they had cited the original article and had nothing new to offer. Three commonly used tampering techniques are in vivo adulteration, urine substitution, and in vitro adulteration. Review of the literature regarding the risks involved with use of tampering kits yielded no results. In 1986, an executive order was issued requiring all federal employees to refrain from illicit drug use, and the 1988 Drug-Free Workplace Act precipitated the Substance Abuse and Mental Health Services Administration guidelines and their subsequent revisions. Recently, many states have made regulatory efforts to bring drug test defrauding under the ambit of law. Clinicians need to be aware of the tampering techniques and the possibility of false-negative urine drug tests. Cognizance of inherent risks involved with using these techniques including psychiatric and/or medical complications is also warranted. The manufacture, sale, and use of these products have little or

Comparing welfare effects of different regulation schemes: An application to the electricity distribution industry

International Nuclear Information System (INIS)

Kopsakangas-Savolainen, Maria; Svento, Rauli

2010-01-01

We compare the welfare effects of different regulation schemes of electricity distribution utilities. The compared regulation schemes are Fixed Price regulation, Cost of Service regulation, Menu of Cost-Contingent Contracts and Simple Menu of Contracts. In our calculations we utilize the information of a firm's potential to improve cost efficiency. The firm-specific cost information of Finnish electricity distribution utilities is obtained by using various Stochastic Frontier models. Our basic result is that welfare can be improved by changing the Cost of Service regulation scheme to the Menu of Contracts regulation. Welfare also increases in the case of Fixed Price regulation and Simple Menu of Contract regulation. There is however, a significant difference among regulation regimes on how this improved welfare is distributed to consumers and producers.

Emotion Chat: A Web Chatroom with Emotion Regulation for E-Learners

Science.gov (United States)

Zheng, Deli; Tian, Feng; Liu, Jun; Zheng, Qinghua; Qin, Jiwei

In order to compensate for lack of emotion communication between teachers and students in e-learning systems, we have designed and implemented the EmotionChat -- a web chatroom with emotion regulation. EmotionChat perceives e-learners' emotional states based on interactive text. And it recommends resources such as music, cartoons, and mottos to an e-learner when it detects negative emotional states. Meanwhile, it recommends emotion regulation cases to the e-learner's listeners and teachers. The result of our initial experiment shows that EmotionChat can recommend valuable emotion regulation policies for e-learners.

The Case of Dr. Oz: Ethics, Evidence, and Does Professional Self-Regulation Work?

Science.gov (United States)

Tilburt, Jon C; Allyse, Megan; Hafferty, Frederic W

2017-02-01

Dr. Mehmet Oz is widely known not just as a successful media personality donning the title "America's Doctor ® ," but, we suggest, also as a physician visibly out of step with his profession. A recent, unsuccessful attempt to censure Dr. Oz raises the issue of whether the medical profession can effectively self-regulate at all. It also raises concern that the medical profession's self-regulation might be selectively activated, perhaps only when the subject of professional censure has achieved a level of public visibility. We argue here that the medical profession must look at itself with a healthy dose of self-doubt about whether it has sufficient knowledge of or handle on the less visible Dr. "Ozes" quietly operating under the profession's presumptive endorsement. © 2017 American Medical Association. All Rights Reserved.

Adopting local alcohol policies: a case study of community efforts to regulate malt liquor sales.

Science.gov (United States)

McKee, Patricia A; Nelson, Toben F; Toomey, Traci L; Shimotsu, Scott T; Hannan, Peter J; Jones-Webb, Rhonda J

2012-01-01

To learn how the local context may affect a city's ability to regulate alcohol products such as high-alcohol-content malt liquor, a beverage associated with heavy drinking and a spectrum of nuisance crimes in urban areas. An exploratory, qualitative case study comparing cities that adopted policies to restrict malt liquor sales with cities that considered, but did not adopt policies. Nine large U.S. cities in seven states. City legislators and staff, alcohol enforcement personnel, police, neighborhood groups, business associations, alcohol retailers, and industry representatives. Qualitative data were obtained from key informant interviews (n = 56) and media articles (n = 360). The data were coded and categorized. Similarities and differences in major themes among and across Adopted and Considered cities were identified. Cities faced multiple barriers in addressing malt liquor-related problems, including a lack of enforcement tools, alcohol industry opposition, and a lack of public and political will for alcohol control. Compared to cities that did not adopt malt liquor sales restrictions, cities that adopted restrictions appeared to have a stronger public mandate for a policy and were less influenced by alcohol industry opposition and lack of legislative authority for alcohol control. Strategies common to successful policymaking efforts are discussed. Understanding the local context may be a critical step in winning support for local alcohol control policies.

Inter-Institutional Comparison on Working Power Loss Evaluated Cases

Directory of Open Access Journals (Sweden)

Volkan Ünal

2016-04-01

Full Text Available Objective: In Turkey, individuals who want to retire due to illness and determined within the provisions of the relevant rules and regulations are defined as 'retirement due to disability1. When the insured apply with a petition, describing that s/he cannot work because of the diseases, retirement process begins. First Social Security Institution in case of objection Social Security Supreme Council of Health prepares reports about individuals. Third Specialization Board of the Council of Forensic Medicine is the final expertise authority on these cases. With this study it is aimed to reveal the decision differences on 'retirement due to disability1 cases between the Third Specialization Board of the Council of Forensic Medicine and the other institutions and, guided with the findings, to provide the standardization in practical implementation. Materials and Methods: For this study; the reports of the 3rd Specialization Board of The Council of Forensic Medicine were retrospectively investigated and the cases who were reported as not suitable for the retirement due to diseases by Social Security Institution and Social Security Supreme Council of Health but reported as suitable for the retirement due to diseases by the 3”1 Specialization Board were included. Results: Totally sixty four cases were determined. Fifty seven of the cases were male and seven ofthem were female. Average age of female cases was 50.71, male cases were 49.89 and average age of all cases was 49.98. Conclusion: Even the rules and regulations are same, there are differences between institutions. While rules and regulations are constituted, taking common decisions by negotiating on practice principles should reduce the differences between institutions and provide faster decision makings. Institutions should arrange routine meetings and discuss about the cases and present assessments interactively. Keywords: Working Power Loss, Inter-Instutional Comparison, Forensic medicine.

7 CFR 29.6005 - Case (order).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Case (order). 29.6005 Section 29.6005 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... content. ...

PDT: special cases in front of legal regulations

Science.gov (United States)

Fischer, E.; Wegner, A.; Pfeiler, T.; Mertz, M.

2002-10-01

Introduction: The classic indication for photodynamic therapy (PDT) in ophthalmology is currently represented by classic subfoveal choroidal neovascularisation (CNV) due to age-related macular degeneration (AMD). PDT is a method, which almost selectively causes endothelial damage in neovascular lesions, followed by vascular occlusion and involution of the CNV. The mechanistic aspect suggests that non AMD-related choroidal neovascularisations might also benefit from PDT. PDT in AMD: Within the German health system, PDT indications follow the criteria based on the inclusion criteria of the TAP studies. For instance the CNV should be predominantly classic and located under the center of the foveal avascular zone. In the diagnosis and follow-up of exudative AMD, visual acuity measurements and fluorescein angiography are the established parameters. Retinal thickness analyzer (RTA) measurements might give further information. Before PDT, they show a significant retinal thickening due to intra- and subretinal exudation. Following PDT, early RTA follow-ups show a clear decrease in retinal thickening accompanies by increasing or stable acuity. PDT in CNV of other origins than AMD: New studies support a new spectrum of indications for PDT, hopefully leading to general cost reimbursement for patients. PDT should be viewed as a general method for vascular occlusion and does not represent a causal therapy for progressive exudative AMD. We present patients with CNV due to pathologic myopia, angioid streaks and POHS. Conclusion: The selective vascular occlusion caused by PDT, besides CNV associated with AMD and pathologic myopia, may also allow the treatment of choroidal neovascularisations based on other entities. Careful individual evaluation of those cases is recommended. Despite this wide array of possible indications, cost reimbursement has been limited to classic subfoveal CNV in AMD, although single case reimbursements in choroidal neovascular lesions due to pathologic

The Improvement Plan on Unifying from Law and Regulations Related to Radiation

International Nuclear Information System (INIS)

Jeong, Dong Kyong; Lee, Jong Back; Park, Myung Hwan

2006-01-01

This is for the purpose to help the bill related to technologists be systematic and unitary by carefully analyzing a legislation, an enforcement ordinance, and enforcement regulations in the connection with the radiological worker and the radiation workers from the law and regulations related to technologists. Concerning technologists, a legislation, an enforcement ordinance, and enforcement regulations for a sort of medical technician, regarding the radiological worker, the rules of diagnosis radiation equipment safety management, and concerning the radiation workers, atomic energy law, an enforcement ordinance and enforcement regulations were gathered, compared with one another, and analyzed. Among technologists, in the case of working in the department of diagnosis radiation, the title 'Radiological Worker' is used by the Medical Service Law, and in the case of working in the department of radiation tumors or the one of nucleus medicine, the title 'Radiation Workers' is used by the Atomic Energy Law. Besides the technical term that is used by characteristic tasks, unification of the terms that can be used in common is necessary for sure. And when a legislation, an enforcement ordinance, enforcement regulations, and notification, things like that in the radiation field are amended, certainly they should be done by mutual agreement through negotiation between the organization related to radiation and the governmental organization.

Conforming with current regulation in Turkey regarding the freezing of oocytes: A case report of the first pregnancy in Turkey achieved through oocyte vitrification

Directory of Open Access Journals (Sweden)

Semra Kahraman MD

2017-01-01

Full Text Available Objectives: To present the first pregnancy achieved in Turkey with frozen–warmed oocytes in a case with previous nine unsuccessful assisted reproductive technology (ART attempts. Methods: The clinical follow-up of a 33-year-old female applying to our ART centre after a long and complicated history of infertility is described. Results: In April 2013, the woman attempted our centre for her 10th ART trial. She informed us on oocyte pick-up (OPU day that her husband had been hospitalized following a car crush in Albania and was unable to travel to our clinic to give a sperm sample. We were therefore placed in the position of having to make an emergency decision. OPU was done and seven oocytes were retrieved. Six metaphase II (MII oocytes out of seven Cumulus Oocyte Complexes (COCs were vitrified using the Kitazato Vitrification Cryotop Kit. Six months later, in November 2013, the patient applied for transfer. Two blastocysts were transferred and the ART trial resulted with a singleton pregnancy and the birth of a healthy new-born at term via cesarean section. Conclusion: Regulation Codes on Assisted Reproductive Procedures and Assisted Reproductive Technology Centres, published in the Official Gazette of the Republic of Turkey, on 6 March 2010 forbade the freezing of gonad cells and tissues except when essential for medical reasons and stated that this would be specified later. However, the Regulation Codes published in the Official Gazette of the Republic of Turkey, on 30 September 2014 provided no further clarification. Unfortunately, the wording of the regulations did not specifically address this unexpected emergency situation. However, we saw our decision to cryopreserve the oocytes as a valid interpretation of the regulations, bearing in mind also the requirement that sperm and oocyte in the IVF process must be those of a married couple. Turkish medicolegal regulations should be revised to increase the chances of more women taking advantage

The Situated Dynamics of Purposes of Engagement and Self-Regulation Strategies: A Mixed-Methods Case Study of Writing

Science.gov (United States)

Kaplan, Avi; Lichtinger, Einat; Margulis, Michal

2011-01-01

Background: Common conceptions of motivation and self-regulation view them as related but distinct entities. Most research on motivation and self-regulation investigates quantitative relations between level (e.g., self-efficacy) or type of motivation (e.g., mastery goals) and level of self-regulation. Purpose: Alternatively, the current study…

Continuously revised assurance cases with stakeholders’ cross-validation: a DEOS experience

Directory of Open Access Journals (Sweden)

Kimio Kuramitsu

2016-12-01

Full Text Available Recently, assurance cases have received much attention in the field of software-based computer systems and IT services. However, software changes very often, and there are no strong regulations for software. These facts are two main challenges to be addressed in the development of software assurance cases. We propose a method of developing assurance cases by means of continuous revision at every stage of the system life cycle, including in operation and service recovery in failure cases. Instead of a regulator, dependability arguments are validated by multiple stakeholders competing with each other. This paper reported our experience with the proposed method in the case of Aspen education service. The case study demonstrates that continuous revisions enable stakeholders to share dependability problems across software life cycle stages, which will lead to the long-term improvement of service dependability.

Regulative environmental policy. Regulative Umweltpolitik

Energy Technology Data Exchange (ETDEWEB)

Goerlitz, A; Voigt, R [Universitaet der Bundeswehr Muenchen, Neubiberg (Germany, F.R.). Fakultaet fuer Sozialwissenschaften; eds.

1991-01-01

Regulative policy means those governmental attempts to steer the course of things which can fall back on a certain repertoire of instruments for actions in order to warrant the causal and temporal connection between the making available and the employment of means. The fact that environmental protection needs regulative policy is substantiated by the thesis that the market has failed; consequently only government can manage the public goods 'environment' in a suitable way, and it is a matter of fact that environmental protection at present is operated preferably via regulative policy. The problems of regulative enviromental policy are manifold. Its implementation often miscarries because of limited administrative resources on the one hand - making sufficient control impossible for instance -, and because of poor quality regulative instruments on the other hand. One way out would be to increase the efficiency of regulative policy by sophisticating judicial techniques. Other ways out point to the executing level and aim at improving implementation strategies or are concerned with post-regulative law. The latter refers to a new legal quality which demonstrates itself already in corporatistical crisis regulation or in induction programs such as pollution limits. A final way out favours deregulation strategies which includes the introduction of environmental levies or the allocation of environmental licences. An interdisciplinary discourse is to find out what would happen if these ways were taken. Pointers to solutions from varying scientific disciplines resulting from this discourse are to be found in this volume. (orig./HSCH).

Analysis of concept and application or Risk-Informed Performed-Based Regulation (RI-PBR)

International Nuclear Information System (INIS)

Kim, W. S.; Sung, K. Y.; Lee, C. J.; Kim, H. J.

2002-01-01

For improving regulation of nuclear power plants, the USNRC is adopting the Risk-Informed Performance-Based Regulation (RI-PBR) as an alternative, in parallel with implementing current deterministic regulation. This paper introduces a research plan for 'Institutionalization of RI-PBR' that is being conducted by KINS as a national project for evaluating feasibility for application of the alternative to Korean regulation system. Analysis of regulation characteristics, case study and experience on RI-PBR were presented as interim research results. In addition, the future plan of development of RI-PBR concept as understandable to the public and evaluation of level of techniques needed for implementation of RI-PBR was introduced

Dynamics of competitive strategies in de-regulated industries: the case of the electricity industry in France

International Nuclear Information System (INIS)

Cateura, O.

2007-11-01

This research work is focused on the competitive dynamics approach and rivalry studies between competitors. It develops theses recent perspectives and particularly multi-market competition (also called multipoint competition) in de-regulated industries (network utilities). Indeed, competitive behaviours in liberalized industries are still badly-known. To conduct this research, we decided to analyze a selection of companies (EDF, Electrabel, Endesa, Enel, Gaz de France, Poweo, Direct Energie..) settled on the French electricity market presently in the course of liberalization (1996 - 2006). This qualitative research, through longitudinal case studies, has been developed thanks to a CIFRE agreement (between the French Ministry of Research and the firm Electrabel France) including action research and participant observation. Using multidimensional strategic sequences, we identified two periods, the first one characterized by a confrontation movement and a second one by mutual forbearance. We argue that after learning the rules of a newly liberalized market (confrontation, diversification, internationalization), competitors rapidly and collectively shift there positions towards a focused European strategy based on the gas-electricity convergence. The development of multi-market competition has conducted to mutual forbearance, which was particularly profitable to the major participants. Integrated strategy (market and non-market) appears as an important driver for legitimizing theses behaviours. (author)

77 FR 39392 - Amendment to the International Traffic in Arms Regulations: Yemen

Science.gov (United States)

2012-07-03

... International Traffic in Arms Regulations: Yemen AGENCY: Department of State. ACTION: Final rule. SUMMARY: The... toward Yemen. Licenses or other approvals for exports or imports of defense articles and defense services destined for or originating in Yemen will be reviewed, and may be issued, on a case-by-case basis. DATES...

HARMONIZATION OF NATIONAL REGULATION AND INTERNATIONAL FINANCIAL REPORTING STANDARDS – PARTICULAR CASE OF NONCURRENT ASSETS

Directory of Open Access Journals (Sweden)

Coste Andreea Ioana

2013-07-01

Full Text Available In the scientific literature, accounting harmonization is a top topic because it helps to increase the comparability of financial statements. Also in Romania in the last 10 years becames a topic that is very often debated. The harmonization is trying to reduce differences of financial reporting statements between countries or, in the other words, it is trying to bring to a common denominator of existing rules when appear conflicts of comparability between them. The purpose of this paper is to measure the harmonisation between national and international regulation for a significant element of financial position statement, such as noncurrent assets. This paper provides an empirical research of information that must be presented by entities which apply national accounting standards or international ones when financial statements are prepared, trying to measure the harmonization between the two referential. Thus, in trying to determine the harmonisation, we use the Jaccard coefficient in order to provide an overview of the degree of harmonization of accounting practice. When measuring the degree of comparability of Romanian accounting regulations with International Accounting Standards we analyzed noncurrent assets and impairment of assets using the Jaccard coefficient for accounting treatments and we calculated an average of similarities between the two regulations. Further, the results suggest that there is an average level of harmonization for the accounting treatment of noncurrent assets and for determining the impairment of the assets, the methods are the same. The study contributes to the development of accounting literature about the harmonisation between national regulation and international standards regarding the noncurrent assets and impairment of the assets, which together with the other elements define the activity of the business. In addition, the study provides an analysis of how the regulations treats noncurrent assets, during the

Influence of Superheated Steam Temperature Regulation Quality on Service Life of Boiler Steam Super-Heater Metal

Directory of Open Access Journals (Sweden)

G. T. Kulakov

2009-01-01

Full Text Available The paper investigates influence of change in quality of superheated steam temperature regulations on service life of super-heater metal. А dependence between metal service life and dispersion value for different steel grades has been determined in the paper. Numerical values pertaining to increase of super-heater metal service life in case of transferring from manual regulation to standard system of automatic regulation (SAR have been determined and in case of transferring from standard SAR to improved SAR. The analysis of tabular data and plotted dependencies makes it possible to conclude that any change in conditions of convection super-heater metal work due to better quality of the regulation leads to essential increase of time period which is left till the completion of the service life of a super-heater heating surface.

A discussion on the resilience of command and control regulation within regulatory behavior theories

Directory of Open Access Journals (Sweden)

K.P.V. O’Sullivan

2012-03-01

Full Text Available This paper provides the first insights into the factors that may drive the resilience of command and control regulation in modern policy making. We show how the forces of uncertainty and internal dynamics among customers, producers and regulators are the most dominate factors preventing the adoption of non-CAC regulations. Using case study evidence of internet regulation, we then integrate our analysis into the most prominent regulatory choice behavior theories and illustrate that regardless of the theory, these factors can help explain the dominance of command and control as a choice of regulation.

Clinical Observation on Insomnia Treated by Wei-Defensive Qi-Regulating and Brain-Strengthening Needling Technique

Institute of Scientific and Technical Information of China (English)

GAO Xi-yan; LI Xing-rui; MA Qiao-lin; ZHAO Xin-ji; SHAO Su-ju; WEI Yu-long; SUN Wei-xia; HANG Guo-qi

2007-01-01

In order to make a report on 90 cases of insomnia treated by the Wei-defensive qi-regulating and brain-strengthening needling technique,as a clinical subject of the multiple center,for assessing the preliminary standardized indications and operating methods and making an initial summary for writing the draft of the technique operation.Methods:By ratio of 1:1,the patients in conformity with the criteria were randomly divided into the experimental group and control group.In the experimental group,45 cases were treated with the Wei-defensive qi-regulating and brain-strengthening needling technique on Baihui (GV 20),Dazhui(GV 14),Shenmai(BL 62),Zhaohai(KI 6),plus ear points.In the control group,45 cases were treated with routine acupuncture on Sishencong(Ex-HN 1),Shenmen (HT 7),Sanyinjiao(SP 6),etc.The therapeutic effects in the two groups were observed and assessed in comparison.Results:The results showed cure in 15 cases.remarkable effect in 27 cases,effect in 42 cases,failure in 6 cases,and the total eriective rate in 94.4% in 90 cases of insomnia.In the three centers,the statistic management was performed based upon PSQI integral and showed significant difference(P＜0.01),and no significant difference among various groups(P＞0.01).Conclusion:The therapeutic effect in the treatment of insomnia by Wei-defensive qi-regulating and brain-strengthening needling technique is better than the control group and the therapeutic effect and methods in various centers are stable.without any deviation.

Economic impact of potential NORM regulations

International Nuclear Information System (INIS)

Smith, G.E.; Fitzgibbon, T.; Karp, S.

1995-01-01

Oil and gas field wastes and sites contaminated with naturally occurring radioactive materials (NORM) have quickly become a focus of substantial attention by regulators both at the state and federal level. Although currently regulated in a number of states, the Environmental Protection Agency (EPA) has indicated a desire to develop federal regulations to address management and disposal of NORM-contaminated wastes. This paper provides a brief overview of current state NORM regulations, currently available technologies for managing and disposing NORM wastes, and the cost of employing these techniques. Based on these characterizations and alternative assumptions about the volume of NORM wastes, four alternative scenarios have been developed to bracket potential future NORM requirements. These scenarios have been used is the basis for an analysis of the potential economic and supply impacts of NORM requirements on the U.S. oil and gas industry. The results illustrate that a reasonable approach to regulation that focuses only on those NORM wastes that pose a risk and allows producers to use safe, low cost disposal methods (downhole or other) would have minimal economic impacts on the oil and gas industry. A very stringent regulatory approach that covered large volumes of wastes, required the use of higher cost disposal techniques, and required extensive site clean-up activities could have a substantial economic impact, resulting in a loss of up to 20 percent of U.S. oil production and 8 percent of U.S. gas production by 2000. The costs of compliance with these alternative approaches could range from $71 million to over $14 billion annually. Between these two cases lies the opportunity for regulators to develop requirements for management and disposal of NORM wastes that will address any environmental and human health risks posed at industry sites without imposing unnecessarily costly regulations on the U.S. oil and gas E ampersand P industry

Frequent down-regulation of ABC transporter genes in prostate cancer.

Science.gov (United States)

Demidenko, Rita; Razanauskas, Deividas; Daniunaite, Kristina; Lazutka, Juozas Rimantas; Jankevicius, Feliksas; Jarmalaite, Sonata

2015-10-12

ATP-binding cassette (ABC) transporters are transmembrane proteins responsible for the efflux of a wide variety of substrates, including steroid metabolites, through the cellular membranes. For better characterization of the role of ABC transporters in prostate cancer (PCa) development, the profile of ABC transporter gene expression was analyzed in PCa and noncancerous prostate tissues (NPT). TaqMan Low Density Array (TLDA) human ABC transporter plates were used for the gene expression profiling in 10 PCa and 6 NPT specimens. ABCB1 transcript level was evaluated in a larger set of PCa cases (N = 78) and NPT (N = 15) by real-time PCR, the same PCa cases were assessed for the gene promoter hypermethylation by methylation-specific PCR. Expression of eight ABC transporter genes (ABCA8, ABCB1, ABCC6, ABCC9, ABCC10, ABCD2, ABCG2, and ABCG4) was significantly down-regulated in PCa as compared to NPT, and only two genes (ABCC4 and ABCG1) were up-regulated. Down-regulation of ABC transporter genes was prevalent in the TMPRSS2-ERG-negative cases. A detailed analysis of ABCB1 expression confirmed TLDA results: a reduced level of the transcript was identified in PCa in comparison to NPT (p = 0.048). Moreover, the TMPRSS2-ERG-negative PCa cases showed significantly lower expression of ABCB1 in comparison to NPT (p = 0.003) or the fusion-positive tumors (p = 0.002). Promoter methylation of ABCB1 predominantly occurred in PCa and was rarely detected in NPT (p ABC transporter genes in PCa, especially in the TMPRSS2-ERG-negative tumors.

Hypoxic regulation of the noncoding genome and NEAT1

Science.gov (United States)

Choudhry, Hani

2016-01-01

Activation of hypoxia pathways is both associated with and contributes to an aggressive phenotype across multiple types of solid cancers. The regulation of gene transcription by hypoxia-inducible factor (HIF) is a key element in this response. HIF directly upregulates the expression of many hundreds of protein-coding genes, which act to both improve oxygen delivery and to reduce oxygen demand. However, it is now becoming apparent that many classes of noncoding RNAs are also regulated by hypoxia, with several (e.g. micro RNAs, long noncoding RNAs and antisense RNAs) under direct transcriptional regulation by HIF. These hypoxia-regulated, noncoding RNAs may act as effectors of the indirect response to HIF by acting on specific coding transcripts or by affecting generic RNA-processing pathways. In addition, noncoding RNAs may also act as modulators of the HIF pathway, either by integrating other physiological responses or, in the case of HIF-regulated, noncoding RNAs, by providing negative or positive feedback and feedforward loops that affect upstream or downstream components of the HIF cascade. These hypoxia-regulated, noncoding transcripts play important roles in the aggressive hypoxic phenotype observed in cancer. PMID:26590207

The regulation of agricultural biotechnology: science shows a better way.

Science.gov (United States)

Miller, Henry I

2010-11-30

National and international regulation of recombinant DNA-modified, or 'genetically engineered' (also referred to as 'genetically modified' or GM), organisms is unscientific and illogical, a lamentable illustration of the maxim that bad science makes bad law. Instead of regulatory scrutiny that is proportional to risk, the degree of oversight is actually inversely proportional to risk. The current approach to regulation, which captures for case-by-case review organisms to be field tested or commercialized according to the techniques used to construct them rather than their properties, flies in the face of scientific consensus. This approach has been costly in terms of economic losses and human suffering. The poorest of the poor have suffered the most because of hugely inflated development costs of genetically engineered plants and food. A model for regulation of field trials known as the 'Stanford Model' is designed to assess risks of new agricultural introductions - whether or not the organisms are genetically engineered, and independent of the genetic modification techniques employed. It offers a scientific, rational, risk-based basis for field trial regulations. Using this sort of model for regulatory review would not only better protect human health and the environment, but would also permit more expeditious development and more widespread use of new plants and seeds. Copyright © 2010 Elsevier B.V. All rights reserved.

[Forensic psychologist's considerations about the new law regulation in cases of sexual crimes].

Science.gov (United States)

Gierowski, Józef Krzysztof

2012-01-01

The article comments, from the perspective of a forensic psychologist, the changes which have been recently provided to the law regulations on sexual crime and the treatment of the sexual crime perpetrators. It appears that the new law regulations follow the right path, because they create the conditions for holistic and complex solutions in the sexual crime treatment matter. Unfortunately they are still rather incomplete and inconsistent. Their practical implementation is difficult because of the very demanding qualification criteria to the psychotherapy of sexual crime perpetrators, the existence of law criteria to the therapy, the narrow frame of the therapy goals and unclear rules of therapy constraint. Moreover, in Poland there is a lack of complex therapy models of sexual perpetrators, we have little experience in this kind of therapy and there is a deficiency of qualified specialists. Finally the relationship between the treatment of this kind of criminals in prison conditions and ambulatory therapy conditions isn't very clearly precise. On the other hand, a lot of improvements have been provided, such as: continuing the treatment after leaving prison, not only pharmacological treatment but also psychotherapy, the system of prevention. Despite of the strong attempts to promote the special role of pharmacological treatment of sexual crime perpetrators (,,chemical castration"), the new solutions promote a complex and interdisciplinary approach to this problem. In this article, the author described the current Polish experience in the therapy of sexual crime perpetrators and listed several rules of preparing the forensic-psychological expertise according to the described problem in context of new legal regulations.

Globalisation reaches gene regulation: the case for vertebrate limb development.

Science.gov (United States)

Zuniga, Aimée

2005-08-01

Analysis of key regulators of vertebrate limb development has revealed that the cis-regulatory regions controlling their expression are often located several hundred kilobases upstream of the transcription units. These far up- or down-stream cis-regulatory regions tend to reside within rather large, functionally and structurally unrelated genes. Molecular analysis is beginning to reveal the complexity of these large genomic landscapes, which control the co-expression of clusters of diverse genes by this novel type of long-range and globally acting cis-regulatory region. An increasing number of spontaneous mutations in vertebrates, including humans, are being discovered inactivating or altering such global control regions. Thereby, the functions of a seemingly distant but essential gene are disrupted rather than the closest.

Intervention organization in case of accident

International Nuclear Information System (INIS)

Genesco, M.

1987-01-01

In France spent fuels are transported according to international regulations, safety is based on packagings. Spent fuel reprocessing requires development of physical protection. Administrative aspects in case of accident and emergency organization are reviewed [fr

Regulation of transport processes across the tonoplast

Science.gov (United States)

Neuhaus, H. Ekkehard; Trentmann, Oliver

2014-01-01

In plants, the vacuole builds up the cellular turgor and represents an important component in cellular responses to diverse stress stimuli. Rapid volume changes of cells, particularly of motor cells, like guard cells, are caused by variation of osmolytes and consequently of the water contents in the vacuole. Moreover, directed solute uptake into or release out of the large central vacuole allows adaptation of cytosolic metabolite levels according to the current physiological requirements and specific cellular demands. Therefore, solute passage across the vacuolar membrane, the tonoplast, has to be tightly regulated. Important principles in vacuolar transport regulation are changes of tonoplast transport protein abundances by differential expression of genes or changes of their activities, e.g., due to post-translational modification or by interacting proteins. Because vacuolar transport is in most cases driven by an electro-chemical gradient altered activities of tonoplast proton pumps significantly influence vacuolar transport capacities. Intense studies on individual tonoplast proteins but also unbiased system biological approaches have provided important insights into the regulation of vacuolar transport. This short review refers to selected examples of tonoplast proteins and their regulation, with special focus on protein phosphorylation. PMID:25309559

Environmental regulation of a power market investment in an international market

Energy Technology Data Exchange (ETDEWEB)

Halseth, Arve; Vennemo, Haakon

1998-12-01

This document examines the optimal environmental regulation of three Norwegian power projects, energy conservation, a natural gas fired combined cycle gas turbine and a new hydro project. All projects reduce emissions elsewhere in the Nordic region, and in general the environmental costs of these emissions are not optimally reflected in market prices. A theory of second best optimal regulation is developed for this case. The optimal regulation is found to deviate considerably from a purely domestic regulation. For instance, it is found optimal to grant a substantial credit to energy conservation. The credit is sensitive to the value of reduced CO{sub 2} emissions and whether the current Norwegian end user tax should be interpreted as an environmental or a fiscal tax. 27 refs., 4 tabs.

Visualization of regulations to support design and quality control--a long-term study.

Science.gov (United States)

Blomé, Mikael

2012-01-01

The aim of the study was to visualize design regulations of furniture by means of interactive technology based on earlier studies and practical examples. The usage of the visualized regulations was evaluated on two occasions: at the start when the first set of regulations was presented, and after six years of usage of all regulations. The visualized regulations were the result of a design process involving experts and potential users in collaboration with IKEA of Sweden AB. The evaluations by the different users showed a very positive response to using visualized regulations. The participative approach, combining expertise in specific regulations with visualization of guidelines, resulted in clear presentations of important regulations, and great attitudes among the users. These kinds of visualizations have proved to be applicable in a variety of product areas at IKEA, with a potential for further dissemination. It is likely that the approaches to design and visualized regulations in this case study could function in other branches.

Federal Aviation Regulations - National Aviation Regulations of Russia

Science.gov (United States)

Chernykh, O.; Bakiiev, M.

2018-03-01

Chinese Aerospace Engineering is currently developing cooperation with Russia on a wide-body airplane project that has directed the work towards better understanding of Russian airworthiness management system. The paper introduces national Aviation regulations of Russia, presents a comparison of them with worldwide recognized regulations, and highlights typical differences. They have been found to be: two general types of regulations used in Russia (Aviation Regulations and Federal Aviation Regulations), non-unified structure of regulations on Aircraft Operation management, various separate agencies responsible for regulation issuance instead of one national aviation authority, typical confusions in references. The paper also gives a list of effective Russian Regulations of both types.

78 FR 18877 - Defense Federal Acquisition Regulation Supplement: New Free Trade Agreement With Colombia (DFARS...

Science.gov (United States)

2013-03-28

... Federal Acquisition Regulation Supplement: New Free Trade Agreement With Colombia (DFARS Case 2012-D032... Regulation Supplement (DFARS) to implement the United States-Colombia Trade Promotion Agreement. This Trade Promotion Agreement is a free trade agreement that provides for mutually non-discriminatory treatment of...

25 CFR 213.26 - Rate of royalty on casing-head gas.

Science.gov (United States)

2010-04-01

... gasoline the minimum rate of royalty shall be 121/2 percent of the value of the casing-head gas, which... operating regulations of the Department. (b) In cases where gas produced and sold has a value for drip gasoline, casing-head gasoline content, and as dry gas from which the casing-head gasoline has been...

Regulation from within: the cytoskeleton in transmembrane signaling

Science.gov (United States)

Jaqaman, Khuloud; Grinstein, Sergio

2013-01-01

There is mounting evidence that the plasma membrane is highly dynamic and organized in a complex manner. The cortical cytoskeleton is proving to be a particularly important regulator of plasmalemmal organization, modulating the mobility of proteins and lipids in the membrane, facilitating their segregation and influencing their clustering. This organization plays a critical role in receptor-mediated signaling, especially in the case of immunoreceptors, which require lateral clustering for their activation. Based on recent developments, we discuss the structures and mechanisms whereby the cortical cytoskeleton regulates membrane dynamics and organization, and how the non-uniform distribution of immunoreceptors and their self-association may affect activation and signaling. PMID:22917551

Lifetime Management in Non-US-Technology Nuclear Power Plants using US Regulations

International Nuclear Information System (INIS)

Cornelius Steenkamp, J.; Encabo Espartero, J.; Garcia Iglesias, R.

2013-01-01

In July 2009 the Spanish Nuclear Regulator (CSN) issued a Safety Instruction (IS-22) for the development of Lifetime Management in the Nuclear Power Plants within Spain. The context of this Safety Instruction is based on the American Regulations 10CFR54, NUREG1800/1801 and the technical guide NEI95-10. All these regulations are aimed at US-Technology Nuclear Power Plants. Lifetime Management of Nuclear Power Plants with a plant design different from US technologies can most certainly be developed with the mentioned US regulations. The successful development of Lifetime Management in these cases depends on the adaptation of the different requirements of the regulations. Challenges resulting from the adaptation process can be resolved by taking into consideration the plant design of the plant in question.

Changing the regulation for regulating the change: Innovation-driven regulatory developments for smart grids, smart metering and e-mobility in Italy

International Nuclear Information System (INIS)

Lo Schiavo, Luca; Delfanti, Maurizio; Fumagalli, Elena; Olivieri, Valeria

2013-01-01

For a long time considered as technologically mature, electric systems are now facing a period of rapid evolution, inspired by climate change concerns. Several studies show that current regulation of natural monopolies does not offer sufficient incentives for network operators (and network users) to participate in this process. Taking Italy as a case study, this paper analyses how energy regulation can change to support the current transformation. We describe the recent regulatory interventions in the domain of smart grids, smart metering and electromobility, with a specific emphasis on the provisions aimed at fostering innovation—an issue that until recently has received almost no attention in the literature nor in the practice of regulation. The progress we observe is considerable in all new areas of concern, and, above all, in the regulator's commitment to provide the right incentives for investments in demonstration projects: the acquisition of experience is regarded as essential to move to more sophisticated regulatory instruments. Finally, regulation is also increasingly concerned with network users, both traditional and new, with the objective to stimulate more active behaviours. - Highlights: ► Regulatory changes in Italy: smart grids, smart metering and electromobility. ► Identification of indicators for regulating innovative investments. ► Demonstration projects for smart grids and EV recharging infrastructures. ► Proposal of an output-based regulation for smart grids. ► Time of Use pricing for residential and small commercial consumers

AN APPROACH TO SELF- AND CO-REGULATION OF ELECTRONIC COMMERCE IN BUILDING TRUST OVER THE INTERNET

Directory of Open Access Journals (Sweden)

R. Serbu

2016-10-01

Full Text Available The goal of this paper is to highlights some thoughts about regulation and self-regulation for e-commerce, to present cases and the importance of co- and self-regulation in e-commerce. There are a couple of question that rise in this area and we will try to answer with this paper: What are the benefits and disadvantages of self- and co-regulation, how can online industry be a cause and effect for self and co-regulation, should our web portal and search engines be a subject to any kind of regulation, what is the impact of the Internet and self and co-regulation on the e-commerce.

Ambition, Regulation and Reality. Complex use of land and water resources in Luwu, South Sulawesi, Indonesia

OpenAIRE

Roth, D.

2003-01-01

In this book I present three case studies of the complex regulation of use of land and water resources in Luwu. Attention to the role of legalcomplexity -the existence of different sources and definitions of normative-legal regulation in the same socio-political space - is an important conceptual point of departure of this study. Each of the three case study sections contains specific conclusions pertaining to the issues involved. The last chapter of the book (chapter 11) is primarily a refle...

National policies and regulations for decommissioning nuclear facilities

International Nuclear Information System (INIS)

1993-07-01

This report, though produced as a follow-up to Safety Series No. 105, The Regulatory Process for the Decommissioning of Nuclear Facilities, is not primarily intended as guidance. Rather, its objective is to provide an overview of national decommissioning policies and regulatory practices as part of the background knowledge which is an essential precondition for good decision making. It discusses the reasons for the similarities and differences in national approach using specific examples but without giving preference to any particular scheme; it aims rather to provide factual, general information on the choices that have been or are being made, and why. As many Member States are in a transient situation between the case-by-case approach to decommissioning and the establishment of national policies, strategies and regulations, this seems the right moment to assess existing national practices worldwide and that is the purpose for which the document is issued at this time. The information gathered in this report is based on submissions by Member States which have developed or are in the process of developing decommissioning oriented policies and regulations. 29 refs

76 FR 23505 - Defense Federal Acquisition Regulation Supplement; Accelerate Small Business Payments (DFARS Case...

Science.gov (United States)

2011-04-27

..., distributive impacts, and equity). Executive Order 13563 emphasizes the importance of quantifying both costs... Regulations System. Therefore, 48 CFR part 232 is amended as follows: PART 232--CONTRACT FINANCING 0 1. The...

Determinants of investment under incentive regulation: The case of the Norwegian electricity distribution networks

International Nuclear Information System (INIS)

Poudineh, Rahmatallah; Jamasb, Tooraj

2016-01-01

Investment in electricity networks, as regulated natural monopolies, is among the highest regulatory and energy policy priorities. The electricity sector regulators adopt different incentive mechanisms to ensure that the firms undertake sufficient investment to maintain and modernise the grid. Thus, an effective regulatory treatment of investment requires understanding the response of companies to the regulatory incentives. This study analyses the determinants of investment in electricity distribution networks using a panel dataset of 129 Norwegian companies observed from 2004 to 2010. A Bayesian Model Averaging approach is used to provide a robust statistical inference by taking into account the uncertainties around model selection and estimation. The results show that three factors drive nearly all network investments: investment rate in previous period, socio-economic costs of energy not supplied and finally useful life of assets. The results indicate that Norwegian companies have, to some degree, responded to the investment incentives provided by the regulatory framework. However, some of the incentives do not appear to be effective in driving the investments. - Highlights: • This paper investigates determinants of investment under incentive regulation. • We apply a Bayesian model averaging technique to deal with model uncertainty. • Dataset comprises 129 Norwegian electricity network companies from 2004 to 2010. • The results show that firms have generally responded to investment incentives. • However, some of the incentives do not appear to have been effective.

DMBT1 expression is down-regulated in breast cancer

DEFF Research Database (Denmark)

Braidotti, P; Nuciforo, P G; Mollenhauer, J

2004-01-01

and hyperplastic mammary cells positive with DMBTh12 were also MCM5-positive. CONCLUSIONS: The redistribution and up-regulation of DMBT1 in normal and hyperplastic tissues flanking malignant tumours and its down-regulation in carcinomas suggests a potential role in breast cancer. Moreover, the concomitant......BACKGROUND: We studied the expression of DMBT1 (deleted in malignant brain tumor 1), a putative tumor suppressor gene, in normal, proliferative, and malignant breast epithelium and its possible relation to cell cycle. METHODS: Sections from 17 benign lesions and 55 carcinomas were immunostained...... expression was down-regulated in the cancerous lesions compared to the normal and/or hyperplastic epithelium adjacent to carcinomas (3/55 positive carcinomas versus 33/42 positive normal/hyperplastic epithelia; p = 0.0001). In 72% of cases RT-PCR confirmed immunohistochemical results. Most of normal...

An approach to self- and co-regulation of electronic Commerce in building trust over the Internet

OpenAIRE

SERBU R.

2016-01-01

The goal of this paper is to highlights some thoughts about regulation and self-regulation for e-commerce, to present cases and the importance of co- and self-regulation in e-commerce. There are a couple of question that rise in this area and we will try to answer with this paper: What are the benefits and disadvantages of self- and co-regulation, how can online industry be a cause and effect for self and co-regulation, should our web portal and search engines be a subject to any kind of regu...

[Food intake regulation - 2nd part].

Science.gov (United States)

Brunerová, Ludmila; Anděl, Michal

2014-01-01

The review article summarizes the principles of hedonic regulation of food intake which represents the food intake independent on the maintenance of homeostasis. The theory describing hedonic regulation, so called Incentive Salience Theory, comprises three major processes: liking (positive attribution to food stimulus), wanting (motivation to gain it) and learning (identification of these stimuli and distinguishing them from those connected with aversive reaction). Neuronal reward circuits are the anatomical and functional substrates of hedonic regulation. They react to gustatory and olfactory (or visual) stimuli associated with food intake. A food item is preferred in case its consumption is connected with a pleasant feeling thus promoting the behavioural reaction. The probability of this reaction after repetitive exposure to such a stimulus is increased (learned preference). On the contrary, learned aversion after repetitive exposure is connected with avoidance of a food item associated with a negative feeling. Main mediators of hedonic regulation are endocannabinoids, opioids and monoamines (dopamine, serotonin). Dopamine in dorsal striatum via D2 receptors generates food motivation as a key means of survival, however in ventral striatum (nucleus accumbens) is responsible for motivation to food bringing pleasure. Serotonin via its receptors 5-HT1A a T-HT2C decreases intake of palatable food. It plays a significant role in the pathogenesis of eating disorders, particularly mental anorexia. There, a food restriction represents a kind of automedication to constitutionally pathologically increased serotonin levels. Detailed understanding of processes regulating food intake is a key to new pharmacological interventions in eating disorders.

Branded prescription drug fee. Final regulations, temporary regulations, and removal of temporary regulations.

Science.gov (United States)

2014-07-28

This document contains final regulations that provide guidance on the annual fee imposed on covered entities engaged in the business of manufacturing or importing branded prescription drugs. This fee was enacted by section 9008 of the Patient Protection and Affordable Care Act, as amended by section 1404 of the Health Care and Education Reconciliation Act of 2010. This document also withdraws the Branded Prescription Drug Fee temporary regulations and contains new temporary regulations regarding the definition of controlled group that apply beginning on January 1, 2015. The final regulations and the new temporary regulations affect persons engaged in the business of manufacturing or importing certain branded prescription drugs. The text of the temporary regulations in this document also serves as the text of proposed regulations set forth in a notice of proposed rulemaking (REG-123286-14) on this subject in the Proposed Rules section in this issue of the Federal Register.

Physiological and brain activity after a combined cognitive behavioral treatment plus video game therapy for emotional regulation in bulimia nervosa: a case report.

Science.gov (United States)

Fagundo, Ana Beatriz; Via, Esther; Sánchez, Isabel; Jiménez-Murcia, Susana; Forcano, Laura; Soriano-Mas, Carles; Giner-Bartolomé, Cristina; Santamaría, Juan J; Ben-Moussa, Maher; Konstantas, Dimitri; Lam, Tony; Lucas, Mikkel; Nielsen, Jeppe; Lems, Peter; Cardoner, Narcís; Menchón, Jose M; de la Torre, Rafael; Fernandez-Aranda, Fernando

2014-08-12

PlayMancer is a video game designed to increase emotional regulation and reduce general impulsive behaviors, by training to decrease arousal and improve decision-making and planning. We have previously demonstrated the usefulness of PlayMancer in reducing impulsivity and improving emotional regulation in bulimia nervosa (BN) patients. However, whether these improvements are actually translated into brain changes remains unclear. The aim of this case study was to report on a 28-year-old Spanish woman with BN, and to examine changes in physiological variables and brain activity after a combined treatment of video game therapy (VGT) and cognitive behavioral therapy (CBT). Ten VGT sessions were carried out on a weekly basis. Anxiety, physiological, and impulsivity measurements were recorded. The patient was scanned in a 1.5-T magnetic resonance scanner, prior to and after the 10-week VGT/CBT combined treatment, using two paradigms: (1) an emotional face-matching task, and (2) a multi-source interference task (MSIT). Upon completing the treatment, a decrease in average heart rate was observed. The functional magnetic resonance imaging (fMRI) results indicated a post-treatment reduction in reaction time along with high accuracy. The patient engaged areas typically active in healthy controls, although the cluster extension of the active areas decreased after the combined treatment. These results suggest a global improvement in emotional regulation and impulsivity control after the VGT therapy in BN, demonstrated by both physiological and neural changes. These promising results suggest that a combined treatment of CBT and VGT might lead to functional cerebral changes that ultimately translate into better cognitive and emotional performances.

Physiological and Brain Activity After a Combined Cognitive Behavioral Treatment Plus Video Game Therapy for Emotional Regulation in Bulimia Nervosa: A Case Report

Science.gov (United States)

Fagundo, Ana Beatriz; Via, Esther; Sánchez, Isabel; Jiménez-Murcia, Susana; Forcano, Laura; Soriano-Mas, Carles; Giner-Bartolomé, Cristina; Santamaría, Juan J; Ben-Moussa, Maher; Konstantas, Dimitri; Lam, Tony; Lucas, Mikkel; Nielsen, Jeppe; Lems, Peter; Cardoner, Narcís; Menchón, Jose M; de la Torre, Rafael

2014-01-01

Background PlayMancer is a video game designed to increase emotional regulation and reduce general impulsive behaviors, by training to decrease arousal and improve decision-making and planning. We have previously demonstrated the usefulness of PlayMancer in reducing impulsivity and improving emotional regulation in bulimia nervosa (BN) patients. However, whether these improvements are actually translated into brain changes remains unclear. Objective The aim of this case study was to report on a 28-year-old Spanish woman with BN, and to examine changes in physiological variables and brain activity after a combined treatment of video game therapy (VGT) and cognitive behavioral therapy (CBT). Methods Ten VGT sessions were carried out on a weekly basis. Anxiety, physiological, and impulsivity measurements were recorded. The patient was scanned in a 1.5-T magnetic resonance scanner, prior to and after the 10-week VGT/CBT combined treatment, using two paradigms: (1) an emotional face-matching task, and (2) a multi-source interference task (MSIT). Results Upon completing the treatment, a decrease in average heart rate was observed. The functional magnetic resonance imaging (fMRI) results indicated a post-treatment reduction in reaction time along with high accuracy. The patient engaged areas typically active in healthy controls, although the cluster extension of the active areas decreased after the combined treatment. Conclusions These results suggest a global improvement in emotional regulation and impulsivity control after the VGT therapy in BN, demonstrated by both physiological and neural changes. These promising results suggest that a combined treatment of CBT and VGT might lead to functional cerebral changes that ultimately translate into better cognitive and emotional performances. PMID:25116416

Oil pollution control mechanisms - statutes and regulations

International Nuclear Information System (INIS)

1978-04-01

The purpose of this analysis is to provide a detailed picture of federal statutes and regulations, as well as case law, bearing on oil spill prevention and control. Emphasis has been placed on federal action occurring after a spill, although some effort is directed toward review of prevention statutes and regulations. In-depth consideration is given the control of oil pollution under the Federal Water Pollution Control Act but this analysis also touches lightly upon acts that have a lesser effect on oil pollution control. These acts being: The Refuse Act; The Ports and Waterways Safety Act of 1972; The Outer Continental Shelf Lands Act; The Oil Pollution Act of 1961; The Deepwater Port Act of 1974, and The Fish and Wildlife Coordination Act

78 FR 34020 - Federal Acquisition Regulation; Uniform Procurement Identification

Science.gov (United States)

2013-06-06

...: Submit comments in response to FAR Case 2012-023 by any of the following methods: Regulations.gov : http... defined to mean a distinct six- position code consisting of a combination of alpha and/or numeric... 17 alpha and/or numeric characters configured to convey certain information. Positions one through...

Regulating the health care workforce: next steps for research.

Science.gov (United States)

Davies, Celia

2004-01-01

This article explores the recent ferment surrounding professional self-regulation in medicine and other health professions. It reviews the academic literature and sets out an agenda for research. The first section considers definitions, acknowledging the particularly complex regulatory maze in UK health care at present, in which professional self-regulation is only one part. The second section reviews academic writing, currently dispersed among the disciplines. 'The logic of light touch regulation', a feature of the 19th century establishment of the General Medical Council, can perhaps shed light on present debates. Alongside the intense political spotlight on regulation in the wake of the Bristol case, consumer-led research and consumer pressure to rethink the principles of regulation has emerged. This is examined in the third section. Finally, themes for research are advanced. First, there is a need to explore the changing relationship between the state and professions and implications, not only for the professions but for health care more broadly. Second, calls for a new professionalism need to be given clearer content. Third, the moves towards more lay involvement in regulatory bodies need study. Fourth, questions of human rights and professional registers must be explored. Fundamental questions of what professional self-regulation can hope to achieve and where it fits in relation to government ambitions as a whole, remain unresolved. Alongside the work programme of the new overarching regulator, there may well be scope for a new style of public enquiry covering the whole territory of regulation.

QF certification and state regulation of retail sales

International Nuclear Information System (INIS)

Gross, T.P.

1990-01-01

This article examines the relationship of qualify facilities (QFs) and the industrial facilities to which they provide power. The paper presents case histories of Alcon and Puerto Rico Electric Power Authority versus FERC, Union Carbide Corporation and Fina Oil and Chemical Company versus FERC, state decisions regarding regulation of retail sales by QFs and steps to avoiding similar confrontations

The common denominator of the Trafigura Case, Foreign Direct Liability Cases and the Rome II Regulation

NARCIS (Netherlands)

Enneking, L.F.H.

2008-01-01

As part of a current trend towards so-called ‘foreign direct liability cases’, attempts are being made to hold parent companies of multinational corporations liable in their home countries for damage caused in host countries. This trend, of which the Trafi gura case serves as a recent example here,

A walk into the LuxR regulators of Actinobacteria: phylogenomic distribution and functional diversity.

Directory of Open Access Journals (Sweden)

Catarina Lopes Santos

Full Text Available LuxR regulators are a widely studied group of bacterial helix-turn-helix (HTH transcription factors involved in the regulation of many genes coding for important traits at an ecological and medical level. This regulatory family is particularly known by their involvement in quorum-sensing (QS mechanisms, i.e., in the bacterial ability to communicate through the synthesis and binding of molecular signals. However, these studies have been mainly focused on gram-negative organisms, and the presence of LuxR regulators in the gram-positive Actinobacteria phylum is still poorly explored. In this manuscript, the presence of LuxR regulators among Actinobacteria was assayed using a domain-based strategy. A total of 991 proteins having one LuxR domain were identified in 53 genome-sequenced actinobacterial species, of which 59% had an additional domain. In most cases (53% this domain was REC (receiver domain, suggesting that LuxR regulators in Actinobacteria may either function as single transcription factors or as part of two-component systems. The frequency, distribution and evolutionary stability of each of these sub-families of regulators was analyzed and contextualized regarding the ecological niche occupied by each organism. The results show that the presence of extra-domains in the LuxR-regulators was likely driven by a general need to physically uncouple the signal sensing from the signal transduction. Moreover, the total frequency of LuxR regulators was shown to be dependent on genetic, metabolic and ecological variables. Finally, the functional annotation of the LuxR regulators revealed that the bacterial ecological niche has biased the specialization of these proteins. In the case of pathogens, our results suggest that LuxR regulators can be involved in virulence and are therefore promising targets for future studies in the health-related biotechnology field.

A Walk into the LuxR Regulators of Actinobacteria: Phylogenomic Distribution and Functional Diversity

Science.gov (United States)

Santos, Catarina Lopes; Correia-Neves, Margarida; Moradas-Ferreira, Pedro; Mendes, Marta Vaz

2012-01-01

LuxR regulators are a widely studied group of bacterial helix-turn-helix (HTH) transcription factors involved in the regulation of many genes coding for important traits at an ecological and medical level. This regulatory family is particularly known by their involvement in quorum-sensing (QS) mechanisms, i.e., in the bacterial ability to communicate through the synthesis and binding of molecular signals. However, these studies have been mainly focused on Gram-negative organisms, and the presence of LuxR regulators in the Gram-positive Actinobacteria phylum is still poorly explored. In this manuscript, the presence of LuxR regulators among Actinobacteria was assayed using a domain-based strategy. A total of 991 proteins having one LuxR domain were identified in 53 genome-sequenced actinobacterial species, of which 59% had an additional domain. In most cases (53%) this domain was REC (receiver domain), suggesting that LuxR regulators in Actinobacteria may either function as single transcription factors or as part of two-component systems. The frequency, distribution and evolutionary stability of each of these sub-families of regulators was analyzed and contextualized regarding the ecological niche occupied by each organism. The results show that the presence of extra-domains in the LuxR-regulators was likely driven by a general need to physically uncouple the signal sensing from the signal transduction. Moreover, the total frequency of LuxR regulators was shown to be dependent on genetic, metabolic and ecological variables. Finally, the functional annotation of the LuxR regulators revealed that the bacterial ecological niche has biased the specialization of these proteins. In the case of pathogens, our results suggest that LuxR regulators can be involved in virulence and are therefore promising targets for future studies in the health-related biotechnology field. PMID:23056438

A regulator's viewpoint on the use of AI in the nuclear industry

International Nuclear Information System (INIS)

Wainwright, N.

1995-01-01

The regulatory position within the UK places the responsibility for safety on a nuclear site with the licensee. The licensee must produce a safety case that demonstrates that the plant is safe. Assessment of this safety case is performed by the regulator in the Health and Safety Executive (HSE) using HSE's published Safety Assessment Principles. This paper presents the personal views of a regulator on the use of artificial intelligence (AI) in the nuclear industry. The AI-based system considered are restricted to expert systems, neural networks and fuzzy logic. Some of the safety issues are discussed. The particular concerns associated with software-based systems are compounded by some of the inherent problems of AI-based systems. Such is the nature of these concerns that an acceptable safety case will be difficult to mount for safety systems and post-accident monitoring systems. However, given the present maturity of the technology, acceptable safety cases might be formulated in the areas of operator advisory systems designed to reduce accident frequencies, and robotics where dose reduction is important. There are also arguments that suggests that suitable safety cases could be formulated for AI-based plant control systems. Nevertheless, AI-based systems should be treated with caution - further research is required into suitable designs and safety demonstration techniques. (author)

Self-regulated learning of aural skills in undergraduate music courses: a case study

Directory of Open Access Journals (Sweden)

Pablo da Silva Gusmão

2011-12-01

Full Text Available Aural Skills classes, which are required and collective, present some particular issues at the Brazilian universities, such as the diverse student’s proficiency levels, motivational issues and lack of autonomy for learning. This paper present the results of a research that investigated the relationships between the psychological constructs involved in the self- regulation of aural skills learning in Undergraduate music students. Through semi-structured interviews, the objective was to understand the interaction of the processes described in Zimmerman (2002 in the three student’s narratives. In this initial research, it was possible to see a relationship between the achievement in Aural Skill courses and the utilization of self- regulatory process, particularly goal-setting and efficient time management, as well as the lack of strategies related to the division of goals into proximal and specific sub-goals, and to the definition of self-evaluation standards. The investigation of strategies for intervention on cognitive processes involved with self-regulated learning of aural skills may help students to become more motivated and autonomous in their academic study.

Innovation in regulation of rapidly changing health markets.

Science.gov (United States)

Bloom, Gerald; Henson, Spencer; Peters, David H

2014-06-24

The rapid evolution and spread of health markets across low and middle-income countries (LMICs) has contributed to a significant increase in the availability of health-related goods and services around the world. The support institutions needed to regulate these markets have lagged behind, with regulatory systems that are weak and under-resourced. This paper explores the key issues associated with regulation of health markets in LMICs, and the different goals of regulation, namely quality and safety of care, value for money, social agreement over fair access and financing, and accountability. Licensing, price controls, and other traditional approaches to the regulation of markets for health products and services have played an important role, but they have been of questionable effectiveness in ensuring safety and efficacy at the point of the user in LMICs. The paper proposes a health market systems conceptual framework, using the value chain for the production, distribution and retail of health goods and services, to examine regulation of health markets in the LMIC context. We conclude by exploring the changing context going forwards, laying out implications for future heath market regulation. We argue that the case for new approaches to the regulation of markets for health products and services in LMICs is compelling. Although traditional "command and control" approaches will have a place in the toolkit of regulators, a broader bundle of approaches is needed that is adapted to the national and market-level context of particular LMICs. The implication is that it is not possible to apply standard or single interventions across countries, as approaches proven to work well in one context will not necessarily work well elsewhere.

[Revision of the drinking water regulations].

Science.gov (United States)

Hauswirth, S

2011-11-01

The revision the Drinking Water Regulations will come into effect on 01.11.2011. Surveillance authorities and owners of drinking water supply systems had hoped for simplifications and reductions because of the new arrangements. According to the official statement for the revision the legislature intended to create more clarity, consider new scientific findings, to change regulations that have not been proved to close regulatory gaps, to deregulate and to increase the high quality standards. A detailed examination of the regulation text, however, raises doubts. The new classification of water supply systems requires different modalities of registration, water analyses and official observation, which will complicate the work of the authorities. In particular, the implementation of requirements of registration and examination for the owners of commercial and publicly-operated large hot-water systems in accordance with DVGW Worksheet W 551 requires more effort. According to the estimated 30 000 cases of legionellosis in Germany the need for a check of such systems for Legionella, however, is not called into question. Furthermore, the development of sampling plans and the monitoring of mobile water supply systems requires more work for the health authorities. © Georg Thieme Verlag KG Stuttgart · New York.

The Role of Motivation in Self-regulated Learning and Language Learning Strategy: In the Case of Chinese EFL Learners

Directory of Open Access Journals (Sweden)

Maryam Banisaeid

2015-09-01

Full Text Available Although self-regulation, derived from educational psychology, is a new topic in the second language learning field, language learning strategy was the main focus of many studies in the last two decades. Also, among the L2 individual differences, motivation plays an important role in achieving the educational goals. In this research, motivation is investigated from self-determination theory by which five types of motivation are presented. No study was found to investigate the role of motivation in both self-regulation and language learning strategy. For such a purpose, 49 Chinese EFL learners respond to SILL, MSLQ and LLOS_IEA respectively proposed by Oxford (1990, Pintrich et al (1991 and Noel et al (2000. The results running Pearson correlation showed that there is a significant relationship between motivation, self-regulation and language learning strategies. It is also revealed that Chinese EFL learners use memory, social and affective strategy more than the other ones. The most common motivational orientation is identified regulation. Among self-regulated learning strategies, effort regulation is highly used by them. At the end some implication is considered.

The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer.

Science.gov (United States)

Nishikawa, Jun; Iizasa, Hisashi; Yoshiyama, Hironori; Nakamura, Munetaka; Saito, Mari; Sasaki, Sho; Shimokuri, Kanami; Yanagihara, Masashi; Sakai, Kouhei; Suehiro, Yutaka; Yamasaki, Takahiro; Sakaida, Isao

2017-07-25

The Epstein-Barr virus (EBV) is detected in about 10% of gastric carcinoma cases throughout the world. In EBV-associated gastric carcinoma (EBVaGC), all tumor cells harbor the clonal EBV genome. The expression of latent EBV genes is strictly regulated through the methylation of EBV DNA. The methylation of viral DNA regulates the type of EBV latency, and methylation of the tumor suppressor genes is a key abnormality in EBVaGC. The methylation frequencies of several tumor suppressor genes and cell adhesion molecules are significantly higher in EBVaGC than in control cases. EBV-derived microRNAs repress translation from viral and host mRNAs. EBV regulates the expression of non-coding RNA in gastric carcinoma. With regard to the clinical application of demethylating agents against EBVaGC, we investigated the effects of decitabine against the EBVaGC cell lines. Decitabine inhibited the cell growth of EBVaGC cells. The promoter regions of p73 and Runt-related transcription factor 3(RUNX3) were demethylated, and their expression was upregulated by the treatment. We review the role of epigenetic regulation in the development and maintenance of EBVaGC and discuss the therapeutic application of DNA demethylating agents for EBVaGC.

To regulate or not to regulate?

Energy Technology Data Exchange (ETDEWEB)

Mason, G.; Wrixon, A. [IAEA, Vienna (Austria)

2006-07-01

Full text of publication follows: In Hamlet famous soliloquy to be or not to be, he wrestles with the perennial human problem of choosing the right course of action in difficult circumstances. In recent years, we have witnessed a cast of thousands playing out a long-running scene that seems to echo Hamlet dilemma on a rather more prosaic level. When is it necessary to apply regulations to the control of exposure to ionizing radiation and when is regulatory control not warranted? This seemingly straightforward question has brought out the philosopher, ethician, lawyer, pragmatist, orator in simple radiation protection folk and has led to passionate debate on numerous occasions. This paper attempts an answer based on a review of recent developments. For deciding when to apply regulatory controls, several concepts have evolved over time, including exemption of practices and sources, exclusion of exposures and clearance of materials. These have different origins, purposes and characteristics. Exemption and clearance have often been associated with triviality of risk, while exclusion has been related to un-amenability of control. For each concept, criteria have been developed to assist the regulator in reaching a decision, but there has much disputation over numerical values. This paper briefly reviews and analyses recent developments and attempts to clarify the problem from first principles. The conclusion is that the underlying issue in each case is to determine when regulatory controls become unwarranted: that is, when the societal resources expended in applying them and complying with them would be disproportionate to any benefit they might bring. This is a natural extension of the principle of optimization of protection to the regulatory control of protection, in the context of exposure to radiation at very low levels. It also reflects common expectations of good governance: wise management of finite societal resources and avoidance of unwarranted controls on

To regulate or not to regulate?

International Nuclear Information System (INIS)

Mason, G.; Wrixon, A.

2006-01-01

Full text of publication follows: In Hamlet famous soliloquy to be or not to be, he wrestles with the perennial human problem of choosing the right course of action in difficult circumstances. In recent years, we have witnessed a cast of thousands playing out a long-running scene that seems to echo Hamlet dilemma on a rather more prosaic level. When is it necessary to apply regulations to the control of exposure to ionizing radiation and when is regulatory control not warranted? This seemingly straightforward question has brought out the philosopher, ethician, lawyer, pragmatist, orator in simple radiation protection folk and has led to passionate debate on numerous occasions. This paper attempts an answer based on a review of recent developments. For deciding when to apply regulatory controls, several concepts have evolved over time, including exemption of practices and sources, exclusion of exposures and clearance of materials. These have different origins, purposes and characteristics. Exemption and clearance have often been associated with triviality of risk, while exclusion has been related to un-amenability of control. For each concept, criteria have been developed to assist the regulator in reaching a decision, but there has much disputation over numerical values. This paper briefly reviews and analyses recent developments and attempts to clarify the problem from first principles. The conclusion is that the underlying issue in each case is to determine when regulatory controls become unwarranted: that is, when the societal resources expended in applying them and complying with them would be disproportionate to any benefit they might bring. This is a natural extension of the principle of optimization of protection to the regulatory control of protection, in the context of exposure to radiation at very low levels. It also reflects common expectations of good governance: wise management of finite societal resources and avoidance of unwarranted controls on

On Secondary Control Approaches for Voltage Regulation in DC Microgrids

DEFF Research Database (Denmark)

Peyghami Akhuleh, Saeed; Mokhtari, Hossein; Davari, Pooya

2017-01-01

Centralized or decentralized secondary controller is commonly employed to regulate the voltage drop raised by the primary controller. However, in the case of high capacity MGs and long feeders with much voltage drop on the line resistances, the conventional methods may not guarantee the voltage...

The Regulation of Nuclear Trade: Non-Proliferation-Supply-safety

International Nuclear Information System (INIS)

1988-01-01

Volume II of the study on the regulation of nuclear trade deals with the national legislation of OECD countries with significant nuclear programmes and regulations in that field and, in essence, covers two aspects. The first concerns political and administrative controls over imports and exports of sensitive products, namely fissile materials and large nuclear equipment as well as technology transfers. In most cases, this description of the provisions applicable is completed with the list of nuclear items whose export is restricted. The second aspect concerns the licensing system governing trade in as well as the import and export of nuclear material to protect users and the public against the hazards created by its radioactive properties. This volume also contains information on regulations concerning physical protection, industrial property and transport, as well as on multilateral and bilateral agreements involving nuclear trade. (NEA) [fr

Regulations and standardization relative to the biomass combustion

International Nuclear Information System (INIS)

Autret, E.

2009-01-01

It does not exist regulations on pollutants emissions on domestic wood burning furnaces, however, these appliances are submitted to the European and french standardization concerning the safety rules, the use rules and the tests methods. Since 2007, these wood burning appliances on the market must have the European Community label. The green flame label was elaborated by the environment and energy control Agency (A.D.E.M.E.), and manufacturers of domestic appliances to promote the use of competitive wood burning appliances. concerning the collective and industrial heating, the installations of more 2 MW are framed by different categories of the installations classified for environment protection (I.C.P.E.) regulation according their fuel and power. The combustion installations of less than 2 MW are a particular case, they are framed by a sanitary department regulation and are controlled by the department directions of sanitary and social affairs. the limit values of emissions are summarized in tables. (N.C.)

Regulation of transport processes across the tonoplast membrane

Directory of Open Access Journals (Sweden)

Oliver eTrentmann

2014-09-01

Full Text Available In plants, the vacuole builds up the cellular turgor and represents an important component in cellular responses to diverse stress stimuli. Rapid volume changes of cells, particularly of motor cells, like guard cells, are caused by variation of osmolytes and consequently of the water contents in the vacuole. Moreover, directed solute uptake into or release out of the large central vacuole allows adaptation of cytosolic metabolite levels according to the current physiological requirements and specific cellular demands. Therefore, solute passage across the vacuolar membrane, the tonoplast, has to be tightly regulated. Important principles in vacuolar transport regulation are changes of tonoplast transport protein abundances by differential expression of genes or changes of their activities, e.g. due to post-translational modification or by interacting proteins. Because vacuolar transport is in most cases driven by an electro-chemical gradient altered activities of tonoplast proton pumps significantly influence vacuolar transport capacities. Intense studies on individual tonoplast proteins but also unbiased system biological approaches have provided important insights into the regulation of vacuolar transport. This short review refers to selected examples of tonoplast proteins and their regulation, with special focus on protein phosphorylation.

Regulation of oil trading: a U.S. and U.K. legal update (or) Death of Transnor

International Nuclear Information System (INIS)

Turck, N.B.

1992-01-01

Current law in the USA and United Kingdom relating to commodities trading in oil and oil products is an area of uncertainty and case law is not necessarily consistent with regulation. The principal laws relating to commodities trading are reviewed and analysed as they apply to the oil market. In the case of the USA this is the Commodities Exchange Act (CEA) administered by the Commodities Future Trading Commission (CFTC). Conflicting interpretations of the CEA of the US Federal Court in a case concerning the Brent crude transactions of the Transnor company, and by the CFTC, are examined. In contrast to the USA, where transactions and the market are regulated, the United Kingdom regulation is aimed at the traders and their behaviour. In the United Kingdom, the Financial Services Act 1986 (FSA) established self-regulating professional bodies to issue rules governing the conduct of entities carrying on investment business. Rules applying to oil and product traders are issued and enforced by the Security and Futures Authority Ltd (SFA). Additionally the Securities and Investment Board (SIB), the umbrella organisation of the regulatory bodies established by the FSA, has produced an Oil Market Code of Practice which is appended to this article. (UK)

Normotension, hypertension and body fluid regulation

DEFF Research Database (Denmark)

Bie, Peter; Evans, R G

2017-01-01

The fraction of hypertensive patients with essential hypertension (EH) is decreasing as the knowledge of mechanisms of secondary hypertension increases, but in most new cases of hypertension the pathophysiology remains unknown. Separate neurocentric and renocentric concepts of aetiology have...... activity are elevated in about 50% of cases; (iii) in EH as in normal conditions, mediators other than arterial blood pressure are the major determinants of renal sodium excretion; (iv) chronic hypertension is always associated with a shift in the pressure-natriuresis curve, but this may...... prevailed without much interaction. In this regard, several questions regarding the relationships between body fluid and blood pressure regulation are pertinent. Are all forms of EH associated with sympathetic overdrive or a shift in the pressure-natriuresis curve? Is body fluid homoeostasis normally driven...

The right indemnity in the case of expropriation constraint reiteration

Directory of Open Access Journals (Sweden)

Stefano Carrer

2013-08-01

Full Text Available Section 39 of the current consolidated expropriation act states: “while expecting a systematic re-regulation of the matter, in the case of reiteration of a preordered constraint or a practical expropriation constraint, the estate owner is entitled to an indemnity comparable to the amount of damage actually produced”. To this date the “systematic re-regulation of the matter” has not taken place; failing specific regulations, the estimate indemnity cannot therefore be quantified.

Emotion regulation in schema therapy and dialectical behavior therapy

Directory of Open Access Journals (Sweden)

Eva Fassbinder

2016-09-01

Full Text Available Schema therapy (ST and dialectical behavior therapy (DBT have both shown to be effective treatment methods especially for borderline personality disorder. Both, ST and DBT, have their roots in cognitive behavioral therapy and aim at helping patient to deal with emotional dysregulation. However, there are major differences in the terminology, explanatory models and techniques used in the both methods. This article gives an overview of the major therapeutic techniques used in ST and DBT with respect to emotion regulation and systematically puts them in the context of James Gross’ process model of emotion regulation. Similarities and differences of the two methods are highlighted and illustrated with a case example. A core difference of the two approaches is that DBT directly focusses on the acquisition of emotion regulation skills, whereas ST does seldom address emotion regulation directly. All DBT-modules (mindfulness, distress tolerance, emotion regulation, interpersonal effectiveness are intended to improve emotion regulation skills and patients are encouraged to train these skills on a regular basis. DBT assumes that improved skills and skills use will result in better emotion regulation. In ST problems in emotion regulation are seen as a consequence of adverse early experiences (e.g. lack of safe attachment, childhood abuse or emotional neglect. These negative experiences have led to unprocessed psychological traumas and fear of emotions and result in attempts to avoid emotions and dysfunctional meta-cognitive schemas about the meaning of emotions. ST assumes that when these underlying problems are addressed, emotion regulation improves. Major ST techniques for trauma processing, emotional avoidance and dysregulation are limited reparenting, empathic confrontation and experiential techniques like chair dialogues and imagery rescripting.

Emotion Regulation in Schema Therapy and Dialectical Behavior Therapy

Science.gov (United States)

Fassbinder, Eva; Schweiger, Ulrich; Martius, Desiree; Brand-de Wilde, Odette; Arntz, Arnoud

2016-01-01

Schema therapy (ST) and dialectical behavior therapy (DBT) have both shown to be effective treatment methods especially for borderline personality disorder. Both, ST and DBT, have their roots in cognitive behavioral therapy and aim at helping patient to deal with emotional dysregulation. However, there are major differences in the terminology, explanatory models and techniques used in the both methods. This article gives an overview of the major therapeutic techniques used in ST and DBT with respect to emotion regulation and systematically puts them in the context of James Gross' process model of emotion regulation. Similarities and differences of the two methods are highlighted and illustrated with a case example. A core difference of the two approaches is that DBT directly focusses on the acquisition of emotion regulation skills, whereas ST does seldom address emotion regulation directly. All DBT-modules (mindfulness, distress tolerance, emotion regulation, interpersonal effectiveness) are intended to improve emotion regulation skills and patients are encouraged to train these skills on a regular basis. DBT assumes that improved skills and skills use will result in better emotion regulation. In ST problems in emotion regulation are seen as a consequence of adverse early experiences (e.g., lack of safe attachment, childhood abuse or emotional neglect). These negative experiences have led to unprocessed psychological traumas and fear of emotions and result in attempts to avoid emotions and dysfunctional meta-cognitive schemas about the meaning of emotions. ST assumes that when these underlying problems are addressed, emotion regulation improves. Major ST techniques for trauma processing, emotional avoidance and dysregulation are limited reparenting, empathic confrontation and experiential techniques like chair dialogs and imagery rescripting. PMID:27683567

Relationship between anger regulation and self-image inelderly people

Directory of Open Access Journals (Sweden)

Bernarda Bereza

2013-12-01

Full Text Available Aim: The picture of elderly people, narrowly understood, tends to be quite explicitly associated, namely as either embittered, grumpy, tyrannizing their family and friends, emotionally unstable or active, gentle and kind. Meanwhile, like in the case of people from younger age groups, the typology of elderly people is slightly more varied, including their way of regulating experienced emotions. The aim of the article was the search for the specificity of anger regulation and the connection between the techniques of anger regulation and self-image in elderly people. Based on Bentovim’s theory, emotion regulation was understood as modulating, modifying, focusing and controlling intense excitement and experienced tension. Material and methods:The sample group consisted of 31 men (study group and 39 women (control group above 64 years of age. The study procedure had a questionnaire form and involved completing psychological tests by subjects, including Self-Expression and Control Scale – SECS (T. van Elderen et al. and the Adjective Check List – ACL (H.G. Gough, A.B. Heilbrun. Results: The groups differed significantly in terms of anger regulation and self-image. There are links between different ways of anger regulation and the real self-image. Conclusions: The way of anger regulation is significant for the self-image experienced by elderly people, while a constructive expression of anger and the effective control of this process give a chance for the optimization of the quality of life of elderly people.

On Secondary Control Approaches for Voltage Regulation in DC Microgrids

DEFF Research Database (Denmark)

Peyghami, Saeed; Mokhtari, Hossein; Davari, Pooya

2017-01-01

Centralized or decentralized secondary controller is commonly employed to regulate the voltage drop raised by the primary controller. However, in the case of high capacity MGs and long feeders with much voltage drop on the line resistances, the conventional methods may not guarantee the voltage r...

The effects of average revenue regulation on electricity transmission investment and pricing

International Nuclear Information System (INIS)

Matsukawa, Isamu

2008-01-01

This paper investigates the long-run effects of average revenue regulation on an electricity transmission monopolist who applies a two-part tariff comprising a variable congestion price and a non-negative fixed access fee. A binding constraint on the monopolist's expected average revenue lowers the access fee, promotes transmission investment, and improves consumer surplus. In a case of any linear or log-linear electricity demand function with a positive probability that no congestion occurs, average revenue regulation is allocatively more efficient than a Coasian two-part tariff if the level of capacity under average revenue regulation is higher than that under a Coasian two-part tariff. (author)

Transport of radioactive material in Sudan practice and regulations

International Nuclear Information System (INIS)

Abdalla, M. K. E.

2010-12-01

In the last couple of decades there has been an impressive increase in applications of radioactive material. Such an extensive and widely spread usage of radioactive materials demands safe transportation of radioactive material from the production site to the application location, as well as quick and effective response in a case of an unexpected transportation event according to Sudan Atomic Energy Commission (SAEC) regulation. The thesis described the local practice for transport of radioactive material as compared to the international standards for radiation protection, and also discussed the emergency procedures that must be follow in case of accident during transport of radioactive material. Furthermore, the objective of this study was also to set proposals for how to cope in the event of a radiological accident. The study methods included survey of current literature on safe transport of radioactive material, survey of national regulations on the subjects in additional to case studies aimed at investigating the practical issues pertinent to transport of radioactive materials in Sudan. A comprehensive review was presented on how to classification of radioactive packages and general requirement for all packaging and packages according to international standard. transport of number of radioactive sources from Khartoum airport to the field was evaluated with regard transport index, category of source, type of package, dose rate around the source, time to destination and means of transport of doses to public, worker are be made. All results were within the limit specified in the national as well as international regulation. The study has addressed for the first time the practice of transport of radioactive material in Sudan. It is anticipated that the results will encourage national organizational and professional bodies to enhance radiation protection and safety of radioactive sources. (Author)

Transport regulation of NORM - a threat to the industry?

International Nuclear Information System (INIS)

Martin, E.J.; Wickens, J.

2004-01-01

Recent changes to the IAEA regulations have led to an increasing number of cases of refusal to ship tantalite because of its radioactivity, which is in fact at a very low level. The consequence of denial of shipment is a disruption of the supply chain which is already being felt by the tantalum industry

International Health Regulations (2005 facilitate communication for in-flight contacts of a Middle East respiratory syndrome case, Hong Kong Special Administrative Region, 2014

Directory of Open Access Journals (Sweden)

Poon Kwok-ming

2015-03-01

Full Text Available The International Health Regulations (IHR (2005 require World Health Organization Member States to notify events fulfilling two of four criteria: (1 serious public health impact; (2 unusual or unexpected event; (3 significant risk of international spread; or (4 significant risk of international travel or trade restrictions.1 In-flight transmission of infections like severe acute respiratory syndrome is well documented.2 With the enormous amount of air travel today, the risk of increasing in-flight transmission and subsequent international spread of infections are increasing. Prompt notification and information sharing under the IHR mechanism is critical for effective contact tracing and prompt control measures. We report on a case of in-flight exposure to an infection with significant public health risks that was successfully resolved using IHR (2005 guidelines.

The effect of environmental regulation on firms' competitive performance: the case of the building & construction sector in some EU regions.

Science.gov (United States)

Testa, Francesco; Iraldo, Fabio; Frey, Marco

2011-09-01

There is a considerable debate on the effects of environmental regulation on competitive performance. Based on survey data, this paper analyzes the two main research questions, derived from literature, on the links between environmental regulation and competitiveness, by focusing on firms operating in the building and construction sector, i.e.: 1) whether environmental policy stringency affects the competitive performance of firms in the building and construction sector 2) and how a specific form of environmental regulation (direct regulation, economic instruments and soft instruments) affects this performance? By applying a regression analysis, we find that a more stringent environmental regulation, measured by inspection frequency, provides a positive impulse for increasing investments in advanced technological equipment and innovative products and on business performance. Moreover, a well-designed "direct regulation" appears to be the most effective policy instrument for prompting the positive impact of environmental policies on innovation and intangible performance while economic instruments do negatively affect business performance. Copyright © 2011 Elsevier Ltd. All rights reserved.

77 FR 50631 - Homeland Security Acquisition Regulation (HSAR); Revision Initiative [HSAR Case 2009-002

Science.gov (United States)

2012-08-22

..., provides guidance and direction for compliance with green purchasing and other sustainable practices...--IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST 0 14. Revise section 3003.101-3 to read as follows: 3003.101-3 Agency regulations. The United States Office of Government Ethics has promulgated...

Ambition, Regulation and Reality. Complex use of land and water resources in Luwu, South Sulawesi, Indonesia

NARCIS (Netherlands)

Roth, D.

2003-01-01

In this book I present three case studies of the complex regulation of use of land and water resources in Luwu. Attention to the role of legalcomplexity -the existence of different sources and definitions of normative-legal regulation in

Inefficient national environmental regulation as a signal of high abatement costs

Energy Technology Data Exchange (ETDEWEB)

Steiner, U.

1997-12-31

This paper analyses the importance of informational asymmetries in international environmental regulation by use of a game theoretic approach of signaling games. More specific it analysis whether it is possible for a government to try to extract higher compensation in an international unidirectoral environmental problem. This may be possible when the national environmental regulation carries a signal of the cost of the regulated industry. In this case the government e.g. by means of inefficient environmental regulation on a national level may try to signal high abatement costs. In spite of the fact that many international environmental problems seem to be solvable by the use of financial payments there are only few examples that compensation payment arrangements have been implemented. As many countries and especially many polluting firms possess better information about abatement costs than the countries that receive the pollution, it is worthwhile to include asymmetric information. Consequently, this paper analyses whether the introduction of asymmetric information about abatement costs may bring forward incentives to misrepresent the true abatement cost in order to capture more compensation. If these incentives turn out to be present, it may explain some of the suspicion against using financial payment in order to induce other countries to join an agreement. The analysis shows that it may indeed be the case that the expected gain from cheating is so large that it gives incentives to use an inefficient national environmental policy. (au) 13 refs.

The Legal Structure of Commercial Banks and Financial Regulation : does organizational form matter for the design of bank regulation?

OpenAIRE

Cedeno-Brea, Enmanuel

2017-01-01

markdownabstractDo the different ways that commercial banks are legally organized matter for the design of financial regulation? It is often assumed that most commercial banks are setup as investor owned business corporations. However, this is not always the case In many jurisdictions, banks are legally organized using a plethora of organizational forms, which include: co-operatives, mutual associations and even nonprofit entities. Thus, some of the distinctive legal attributes and features o...

Climate Change Impacts on Stream Temperature in Regulated River Systems: A Case Study in the Southeastern United States

Science.gov (United States)

Cheng, Y.; Niemeyer, R. J.; Zhang, X.; Yearsley, J. R.; Voisin, N.; Nijssen, B.

2017-12-01

Climate change and associated changes in air temperature and precipitation are projected to impact natural water resources quantity, quality and timing. In the past century, over 280 major dams were built in the Southeastern United States (SEUS) (GRanD database). Regulation of the river system greatly alters natural streamflow as well as stream temperature. Understanding the impacts of climate change on regulated systems, particularly within the context of the Clean Water Act, can inform stakeholders how to maintain and adapt water operations (e.g. regulation, withdrawals). In this study, we use a new modeling framework to study climate change impacts on stream temperatures of a regulated river system. We simulate runoff with the Variable Infiltration Capacity (VIC) macroscale hydrological model, regulated streamflow and reservoir operations with a large-scale river routing-reservoir model (MOSART-WM), and stream temperature using the River Basin Model (RBM). We enhanced RBM with a two-layer thermal stratification reservoir module. This modeling framework captures both the impact of reservoir regulation on streamflow and the reservoir stratification effects on downstream temperatures. We evaluate changes in flow and stream temperatures based on climate projections from two representative concentration pathways (RCPs; RCP4.5 and RCP8.5) from the Coupled Model Intercomparison Project Phase 5 (CMIP5). We simulate river temperature with meteorological forcings that have been downscaled with the Multivariate Constructed Analogs (MACA) method. We are specifically interested in analyzing extreme periods during which stream temperature exceeds water quality standards. In this study, we focus on identifying whether these extreme temperature periods coincide with low flows, and whether the frequency and duration of these operationally-relevant periods will increase under future climate change.

[Drug regulation: theory and practice].

Science.gov (United States)

Zara Yahni, C; Segú Tolsa, L; Font Pous, M; Rovira, J

1998-01-01

Regulation of drugs from the public administration is an activity which is produced in different countries independently from the sanitary model they own. In the field of public financing of drugs there have been several measures to improve the efficiency of their use. However, the analysis of the impact of these measures is complex and this may justify the shortage of objectivable results, especially at long term. The objective of this study is to perform a systematic review of such measures due to the need to have information about the different alternatives before making a decision. The introduction of an isolated measure is in many cases compensated by other changes in other regulating or aiding fields which suggests the creation of an integral strategy which affects different fields (supply/demand of drugs and prescribers). It seems necessary to suggest a social debate taking as a basis the scientific information available at the moment and promote the taking of decisions which lead to a rational use of the available pharmacological resources.

Von Willebrand factor regulation of blood vessel formation.

Science.gov (United States)

Randi, Anna M; Smith, Koval E; Castaman, Giancarlo

2018-06-04

Several important physiological processes, from permeability to inflammation to haemostasis, take place at the vessel wall and are regulated by endothelial cells (EC). Thus, proteins that have been identified as regulators of one process are increasingly found to be involved in other vascular functions. Such is the case for Von Willebrand Factor (VWF), a large glycoprotein best known for its critical role in haemostasis. In vitro and in vivo studies have shown that lack of VWF causes enhanced vascularisation, both constitutively and following ischemia. This evidence is supported by studies on blood outgrowth endothelial cells (BOEC) from patients with lack of VWF synthesis (type 3 von Willebrand disease [VWD]). The molecular pathways are likely to involve VWF binding partners, such as integrin αvβ3, and components of Weibel Palade bodies (WPB), such as Angiopoietin-2 and Galectin-3, whose storage is regulated by VWF; these converge on the master regulator of angiogenesis and endothelial homeostasis, vascular endothelial growth factor (VEGF) signalling. Recent studies suggest that the roles of VWF may be tissue-specific. The ability of VWF to regulate angiogenesis has clinical implications for a subset of VWD patients with severe, intractable gastrointestinal bleeding due to vascular malformations. In this article, we review the evidence showing that VWF is involved in blood vessel formation, discuss the role of VWF high molecular weight multimers in regulating angiogenesis, and the value of studies on BOEC in developing a precision medicine approach to validate novel treatments for angiodysplasia in congenital VWD and acquired von Willebrand syndrome. Copyright © 2018 American Society of Hematology.

Regulating nanomedicine - can the FDA handle it?

Science.gov (United States)

Bawa, Raj

2011-05-01

nanomedicine research and development (R&D) and erode public acceptance of nanoproducts. The end-result of this could be a delay or loss of commercialized nanoproducts. Whether the FDA eventually creates new regulations, tweaks existing ones or establishes a new regulatory center to handle nanoproducts, for the time being it should at least look at nanoproducts on a case-by-case basis. The FDA should not attempt regulation of nanomedicine by applying existing statutes alone, especially where scientific evidence suggests otherwise. Incorporating nanomedicine regulation into the current regulatory scheme is a poor idea. Regulation of nanomedicine must balance innovation and R&D with the principle of ensuring maximum public health protection and safety.

How a regulator is preparing for reviewing a license application file: The case of ASN

International Nuclear Information System (INIS)

Tanguy, Loic

2014-01-01

The French Nuclear Safety Authority (ASN) is an independent administrative authority. It prepares regulation pertaining to the management of radioactive waste, monitors the control of safety of basic nuclear installations that produce or treat waste or are involved in their disposal and performs inspections of waste producers (EDF, AREVA, CEA, hospitals, research centres, etc.) and Andra, the French National Radioactive Waste Management Agency. It regulates the overall system set up by Andra for accepting waste from producers and assesses waste management policy and the practices of radioactive waste producers. It reviews license applications and authorises commissioning of nuclear installations. In order to review technical documents, ASN benefits from the expertise of technical support organisations. The French Institute for Radiation Protection and Nuclear Safety (IRSN) is the main such organisation. ASN has been making efforts to diversify its experts for several years. In preparing its decisions, ASN also calls on the opinions and recommendations of seven Advisory Committees of Experts (GPE), with expert knowledge in the areas of waste, nuclear pressure equipment, medical exposure, non-medical radiation protection, reactors, transport, and laboratories and nuclear plants. ASN consults the GPEs in preparing its main decisions. In particular, they review the preliminary, provisional and final safety analysis reports for each nuclear installation. They can also be consulted about changes in regulations or doctrine. (authors)

Ambition, Regulation and Reality. Complex use of land and water resources in Luwu, South Sulawesi, Indonesia

NARCIS (Netherlands)

Roth, D.

2003-01-01

In this book I present three case studies of the complex regulation of use of land and water resources in Luwu. Attention to the role of legalcomplexity -the existence of different sources and definitions of normative-legal regulation in

Expanding Access to Insurance by the Poor : Policy, Regulation and ...

International Development Research Centre (IDRC) Digital Library (Canada)

Expanding Access to Insurance by the Poor : Policy, Regulation and Supervision of Micro Insurance. This project aims to facilitate poor people's access to insurance products and services as a means of addressing their vulnerability to risk. It will do so by carrying out case studies in five countries. Potential candidates ...

State Performance-Based Regulation Using Multiyear Rate Plans for U.S. Electric Utilities

Energy Technology Data Exchange (ETDEWEB)

Lowry, Mark Newton [Pacific Economics Group Research LLC (United States); Makos, Matt [Pacific Economics Group Research LLC (United States); Deason, Jeff [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Schwartz, Lisa [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2017-07-31

Electric utilities today must contain costs at a time when many need to modernize aging systems and all face major changes in technologies, customer preferences and competitive pressures.Most U.S. electric utility facilities are investor-owned, subject to rate and service regulation by state public utility commissions. Regulatory systems under which these utilities operate affect their performance and ability to meet these challenges. In this business environment, multiyear rate plans have some advantages over traditional rate regulation.The report focuses on key design issues and provides case studies of the multiyear rate plan approach, applicable to both vertically integrated and restructured states. Mark Newton Lowry and Matt Makos of Pacific Energy Group Research and Jeff Deason of Berkeley Lab authored the report; Lisa Schwartz, Berkeley Lab, was project manager and technical editor.The report is aimed primarily at state utility regulators and stakeholders in the state regulatory process. The multiyear rate approach also provides ideas on how to streamline oversight of public power utilities and rural electric cooperatives for their governing boards.Two key provisions of multiyear rate plans strengthen cost containment incentives and streamline regulation: 1. Reducing frequency of rate cases, typically to every four or five years 2. Using an attrition relief mechanism to escalate rates or revenue between rate cases to address cost pressures such as inflation and growth in number of customers, independently of the utility’s own cost Better utility performance can be achieved under well-designed multiyear rate plans while achieving lower regulatory costs. Benefits can be shared between utilities and their customers. But plans can be complex and involve significant changes in the regulatory system. Designing plans that stimulate utility performance without undue risk and share benefits fairly can be challenging.This report discusses the rationale for multiyear

Choosing to regulate: does choice enhance craving regulation?

Science.gov (United States)

Mobasser, Arian; Zeithamova, Dagmar; Pfeifer, Jennifer H

2018-01-01

Abstract Goal-directed behavior and lifelong well-being often depend on the ability to control appetitive motivations, such as cravings. Cognitive reappraisal is an effective way to modulate emotional states, including cravings, but is often studied under explicit instruction to regulate. Despite the strong prediction from Self-Determination Theory that choice should enhance task engagement and regulation success, little is known empirically about whether and how regulation is different when participants choose (vs are told) to exert control. To investigate how choice affects neural activity and regulation success, participants reappraised their responses to images of personally-craved foods while undergoing functional neuroimaging. Participants were either instructed to view or reappraise (‘no-choice’) or chose freely to view or reappraise (‘yes-choice’). Choice increased activity in the frontoparietal control network. We expected this activity would be associated with increased task engagement, resulting in better regulation success. However, contrary to this prediction, choice slightly reduced regulation success. Follow-up multivariate functional neuroimaging analyses indicated that choice likely disrupted allocation of limited cognitive resources during reappraisal. While unexpected, these results highlight the importance of studying upstream processes such as regulation choice, as they may affect the ability to regulate cravings and other emotional states. PMID:29462475

Adaptive compliant structures for flow regulation

Science.gov (United States)

Brinkmeyer, Alex; Theunissen, Raf; M. Weaver, Paul; Pirrera, Alberto

2017-01-01

This paper introduces conceptual design principles for a novel class of adaptive structures that provide both flow regulation and control. While of general applicability, these design principles, which revolve around the idea of using the instabilities and elastically nonlinear behaviour of post-buckled panels, are exemplified through a case study: the design of a shape-adaptive air inlet. The inlet comprises a deformable post-buckled member that changes shape depending on the pressure field applied by the surrounding fluid, thereby regulating the inlet aperture. By tailoring the stress field in the post-buckled state and the geometry of the initial, stress-free configuration, the deformable section can snap through to close or open the inlet completely. Owing to its inherent ability to change shape in response to external stimuli—i.e. the aerodynamic loads imposed by different operating conditions—the inlet does not have to rely on linkages and mechanisms for actuation, unlike conventional flow-controlling devices. PMID:28878567

JURISDICTION, COMPETENT JUDICIAL AUTHORITIES AND PROCEEDINGS UNDER REGULATION (EU NO 650/2012 ON SUCCESSION

Directory of Open Access Journals (Sweden)

Paula Poretti

2016-01-01

Full Text Available Novelties in the field of matters of succession brought by implementation of Regulation (EU No 650/2012 of the European Parliament and of the Council of 4 July 2012 on jurisdiction, applicable law, recognition and enforcement of decisions and acceptance and enforcement of authentic instruments in matters of succession and on the creation of a European Certificate of Succession are disscused in the paper. Especial emphasis is on jurisdiction, competent judicial authority and proceedings under Regulation on succession. In this sense, in the first part of the paper detailed analysis of provisions of Commission Implementing Regulation (EU No 1329/2014 of 9 December 2014 establishing the Forms referred to in Regulation (EU No 650/2012 of the European Parliament and of the Council on jurisdiction, applicable law, recognition and enforcement of decisions and acceptance and enforcement of authentic instruments in matters of succession and on the creation of a European Certificate of Succession and provisions of Croatian Law on implementation of Regulation (EU No 650/2012 of the European Parliament and of the Council on jurisdiction, applicable law, recognition and enforcement of decisions and acceptance and enforcement of authentic instruments in matters of succession and on the creation of a European Certificate of Succession is provided. In the second part of the paper case C404/14 Matoušková v. Republic of Czech is presented and difficulties in determining whether the case at issue falls within the scope of Regulation (EC No 2201/2003 or Regulation No 650/2012 on succession which could occur in matters of succession with cross-border implications are reffered to.

Federal approaches to the regulation of noncigarette tobacco products.

Science.gov (United States)

Freiberg, Michael J A

2012-11-01

Under a grant funded by ClearWay Minnesota(SM) and in partnership with nationally recognized experts in tobacco product regulation, the Public Health Law Center investigated how laws at every level apply, or fail to apply, to noncigarette tobacco products--also called "other tobacco products." During the years 2010-2011, standard legal research techniques were used to identify and compile relevant statutes, regulations, decisions, pleadings, proposals, and related materials. Sources included standard commercial legal databases such as LexisNexis and Westlaw, online sources for pending rules and legislation, and direct contact with courts for legal pleadings and unpublished decisions. These legal authorities related to many aspects of the regulation, including price, flavorants, youth access, marketing restrictions, and product design of other tobacco products. Five of these products were used as case studies: dissolvable tobacco products, electronic cigarettes, little cigars, snus, and water pipes. Research during the years 2010-2011 revealed that the federal regulation of other tobacco products lags behind the regulation of more "traditional" tobacco products, such as cigarettes and moist snuff. Federal regulatory options to expand regulation of these products were identified. The article highlights several federal policy interventions that would address gaps in the regulation of other tobacco products. The FDA must determine whether these interventions will benefit public health and, if so, to what extent--the legal criteria for intervention under the federal Family Smoking Prevention and Tobacco Control Act. Copyright © 2012 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

LAWS, REGULATIONS, FORMALITIES AND FACILITIES/INCENTIVES ON INVESTMENT: A CASE OF BANGLADESH

Directory of Open Access Journals (Sweden)

Sharmeen\tAHMED

2015-12-01

Full Text Available Investment is a crucial component phenomenon for economic and industrial development of a country. The main objective of this paper is to highlight the present investment related laws and regulations in Bangladesh. An analysis has been made to depict different aspects and their impacts on formulations, promotions, incentives and facilities support provided by BOI, BEPZA, BSCIC, Ministry of Finance, Bangladesh Bank and National Board of Revenue to both local and foreign investors. The results of the study indicate that variables related to investment in Bangladesh are highly positive for economic growth and industrial development of the country.

QUANTITATIVE ANALYSIS OF FLUX REGULATION THROUGH HIERARCHICAL REGULATION ANALYSIS

NARCIS (Netherlands)

van Eunen, Karen; Rossell, Sergio; Bouwman, Jildau; Westerhoff, Hans V.; Bakker, Barbara M.; Jameson, D; Verma, M; Westerhoff, HV

2011-01-01

Regulation analysis is a methodology that quantifies to what extent a change in the flux through a metabolic pathway is regulated by either gene expression or metabolism. Two extensions to regulation analysis were developed over the past years: (i) the regulation of V(max) can be dissected into the

Quantitative analysis of flux regulation through hierarchical regulation analysis

NARCIS (Netherlands)

Eunen, K. van; Rossell, S.; Bouwman, J.; Westerhoff, H.V.; Bakker, B.M.

2011-01-01

Regulation analysis is a methodology that quantifies to what extent a change in the flux through a metabolic pathway is regulated by either gene expression or metabolism. Two extensions to regulation analysis were developed over the past years: (i) the regulation of Vmax can be dissected into the

Auctioneers vs. commissaires-priseurs: The carnival mirror of profession regulation in the international art market

Directory of Open Access Journals (Sweden)

Elisabetta Lazzaro

2013-06-01

Full Text Available This paper is a comparative analysis of the recent evolution of the French and the Anglo-Saxon profession regulations of auctioneers in terms of entry barriers and exercise of the profession. Firstly, following Stephen and Love's (1999 framework of the regulation of legal profession, we highlight the differences between regulations focussing on different levels (entry restrictions, advertising, fees, fee contracts, and organisational form. We show that French commissaire-priseurs and Anglo-Saxon auctioneers are bounded to quite opposed rules, relating to both the level of regulation (licensing against registration or certification and the scope of this regulation. Secondly, we try to assess the success of these regulations in terms of economic efficiency by comparing the international markets shares of French and Anglo-Saxon auctioneers. We further highlight how a weak regulation can disturb prices mechanisms and, in some cases, favour speculation. The discussion of some emblematic scandals highlights distortions provoked by a strong, as well as a weak regulation

WNT2B2 mRNA, up-regulated in primary gastric cancer, is a positive regulator of the WNT- beta-catenin-TCF signaling pathway.

Science.gov (United States)

Katoh, M; Kirikoshi, H; Terasaki, H; Shiokawa, K

2001-12-21

Genetic alterations of WNT signaling molecules lead to carcinogenesis through activation of the beta-catenin-TCF signaling pathway. We have previously cloned and characterized WNT2B/WNT13 gene on human chromosome 1p13, which is homologous to proto-oncogene WNT2 on human chromosome 7q31. WNT2B1 and WNT2B2 mRNAs, generated from the WNT2B gene due to alternative splicing of the alternative promoter type, encode almost identical polypeptides with divergence in the N-terminal region. WNT2B2 mRNA rather than WNT2B1 mRNA is preferentially expressed in NT2 cells with the potential of neuronal differentiation. Here, we describe our investigations of expression of WNT2B mRNAs in various types of human primary cancer. Matched tumor/normal expression array analysis revealed that WNT2B mRNAs were significantly up-regulated in 2 of 8 cases of primary gastric cancer. WNT2B2 mRNA rather than WNT2B1 mRNA was found to be preferentially up-regulated in a case of primary gastric cancer (signet ring cell carcinoma). Function of WNT2B1 mRNA and that of WNT2B2 mRNA were investigated by using Xenopus axis duplication assay. Injection of synthetic WNT2B1 mRNA into the ventral marginal zone of fertilized Xenopus eggs at the 4-cell stage did not induce axis duplication. In contrast, ventral injection of synthetic WNT2B2 mRNA induced axis duplication in 90% of embryos (complete axis duplication, 24%). These results strongly suggest that WNT2B2 up-regulation in some cases of gastric cancer might lead to carcinogenesis through activation of the beta-catenin-TCF signaling pathway.

Food advertising and self-regulation: a view from the trenches.

Science.gov (United States)

Hoek, Janet; King, Bronwyn

2008-06-01

This study assessed the logic of arguments advanced when the New Zealand advertising self-regulation complaints board adjudicated a complaint about a food product; in addition, it compared these arguments and the complainant's experience of the process to international best practice criteria relating to independence. Documents relating to a complaint about chicken nuggets were analysed. Shuy's logical framework was used to analyse the arguments advanced; the case was subsequently compared to the best practice criteria advanced in the Madelin (2006) report. Even a well-informed and expert complainant found the system difficult to use and biased in favour of the advertiser. Analysis of rhetorical strategies used to respond to the complaint reveal use of fallacious reasoning, including ad hominem, to which the complainant was unable to respond. In the case reviewed, the New Zealand self-regulatory system did not meet the level of openness, independence or transparency that the complainant expected and that are listed as "best practice" criteria in the Madelin Report. A regulatory system run by a government agency could afford greater protection to complainants and consumers and offer a more balanced adjudication process. As the prevalence of obesity increases, governments are examining how effectively regulation controls marketing activities that encourage consumption of energy dense, nutrient poor foods. This paper raises timely and important questions about the balance and fairness of self-regulation as experienced by a complainant.

26 CFR 521.117 - Claims in cases of double taxation.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 19 2010-04-01 2010-04-01 false Claims in cases of double taxation. 521.117...) REGULATIONS UNDER TAX CONVENTIONS DENMARK General Income Tax Taxation of Nonresident Aliens Who Are Residents of Denmark and of Danish Corporations § 521.117 Claims in cases of double taxation. Under Article XX...

Data considerations for regulation of water contaminants

International Nuclear Information System (INIS)

Schoeny, Rita; Haber, Lynne; Dourson, Michael

2006-01-01

There are several pieces of legislation based on human health assessment that set the framework for U.S. EPA's regulation of water contaminants, such as bromate. The Safe Drinking Water Act, for example, specifies that the best available science be used in support of regulation of drinking water contaminants, and highlights that regulations must provide protection to sensitive human populations. Recent EPA guidance, including the 2005 Cancer Guidelines, emphasize analyzing data, and using defaults only in the absence of adequate data. This represents a major shift from the former practice of invoking default methodologies or values unless it was judged that there were sufficient data to depart from them. The Guidelines further present a framework for assessing data in order to determine if a mode of action (MOA) can be established, based on a modification of the Bradford-Hill criteria for causality. A similar approach is used by the International Programme on Chemical Safety (IPCS). To illustrate the application of the framework for evaluating animal tumors, three case studies are considered here. In the first example (chloroform carcinogenicity), sufficient data exist to identify the MOA in animals, and the data are used to illustrate the evaluation of the plausibility of the animal MOA in humans, taking into account toxicokinetics and toxicodynamics. In this case, the MOA was judged to be relevant to humans, and was used to determine the approach for the cancer quantitation. In the second example (naphthalene inhalation carcinogenicity), the key question is whether the weight of evidence (WOE) is sufficient to establish the MOA in animals. Atrazine-induced mammary tumors form the final example, illustrating the reasoning used to determine that the tumor MOA in animals was not considered relevant to humans; atrazine is therefore considered not likely to be a human carcinogen

LnqR, a TetR-family transcriptional regulator, positively regulates lacticin Q production in Lactococcus lactis QU 5.

Science.gov (United States)

Iwatani, Shun; Ishibashi, Naoki; Flores, Floirendo P; Zendo, Takeshi; Nakayama, Jiro; Sonomoto, Kenji

2016-09-01

Lacticin Q is an unmodified leaderless bacteriocin produced by Lactococcus lactis QU 5. It has been revealed that the production and self-immunity of lacticin Q are facilitated by a gene cluster lnqQBCDEF The gene for a putative TetR-family transcriptional regulator, termed lnqR, was found nearby the lnqQBCDEF cluster, but its involvement in lacticin Q biosynthesis remained unknown. In this study, we created an LnqR-overexpressing QU 5 recombinant by using lactococcal constitutive promoter P32 The recombinant QU 5 showed enhanced production of and self-immunity to lacticin Q. RT-PCR analysis has revealed that an overexpression of LnqR increases the amounts of lnqQBCDEF transcripts, and these six genes are transcribed as an operon in a single transcriptional unit. Interestingly, LnqR expression and thus lacticin Q production by L. lactis QU 5 was found temperature dependent, while LnzR, an LnqR-homologue, in L. lactis QU 14 was expressed in a similar but not identical manner to LnqR, resulting in dissimilar bacteriocin productivities by these strains. This report demonstrates LnqR as the first TetR-family transcriptional regulator involved in LAB bacteriocin biosynthesis and that, as an exceptional case of TetR-family regulators, LnqR positively regulates the transcription of these biosynthetic genes. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Constructing regulation and regulating for energy efficient construction

Energy Technology Data Exchange (ETDEWEB)

Shove, Elizabeth [Lancaster University (United Kingdom). Centre for the Study of Environmental Change

1998-07-01

This project considers the process of formulating energy-related building regulation in the light of the revisions to Part L (Conservation of Fuel and Power) of the Building Regulations for England and Wales. Details are given of the main objectives of the research, namely, the examination of the roles of the UK government, local government and pressure groups in shaping energy efficiency standards, the impacts of environmental regulations, the limits of energy-related regulation, environmental regulation of the building sector, and the features of energy related building control. This control is compared with current practice in other European countries. The methodology of the project involving the review of governmental documents and interviews is described. (UK)

Post-translational regulation enables robust p53 regulation.

Science.gov (United States)

Shin, Yong-Jun; Chen, Kai-Yuan; Sayed, Ali H; Hencey, Brandon; Shen, Xiling

2013-08-30

The tumor suppressor protein p53 plays important roles in DNA damage repair, cell cycle arrest and apoptosis. Due to its critical functions, the level of p53 is tightly regulated by a negative feedback mechanism to increase its tolerance towards fluctuations and disturbances. Interestingly, the p53 level is controlled by post-translational regulation rather than transcriptional regulation in this feedback mechanism. We analyzed the dynamics of this feedback to understand whether post-translational regulation provides any advantages over transcriptional regulation in regard to disturbance rejection. When a disturbance happens, even though negative feedback reduces the steady-state error, it can cause a system to become less stable and transiently overshoots, which may erroneously trigger downstream reactions. Therefore, the system needs to balance the trade-off between steady-state and transient errors. Feedback control and adaptive estimation theories revealed that post-translational regulation achieves a better trade-off than transcriptional regulation, contributing to a more steady level of p53 under the influence of noise and disturbances. Furthermore, post-translational regulation enables cells to respond more promptly to stress conditions with consistent amplitude. However, for better disturbance rejection, the p53- Mdm2 negative feedback has to pay a price of higher stochastic noise. Our analyses suggest that the p53-Mdm2 feedback favors regulatory mechanisms that provide the optimal trade-offs for dynamic control.

Fiscal Drag as an Automatic Stability Tool, in the Case of New Regulation with Price Criteria in Automotive Sectors Special Consumption Tax (SCT

Directory of Open Access Journals (Sweden)

Abdurrahman TARAKTAŞ

2017-12-01

Full Text Available Fiscal drag is a result of real or nominal expanding economy and progressive taxation. In general, individuals are forced to enter the upper tax bracket depending on their increased income or expenditure. More tax burden can result in less consumption. Fiscal drag, lack of spending or excessive taxation can cause the economy to slow down. Traditional view suggests that fiscal drag may serve as a natural automatic stabilizer to cool the economy. However, this view ignores the supply side and in particular the potential effects of the high tax burden on economy. This study examines the extent to which the expected automatic stabilization function can be performed and the possible side effects on economic balances and income distribution of fiscal drag in our country in the case of new regulation with price criteria in automotive sectors Special Consumption Tax (SCT.

Is the regulation of the electronic properties of organic molecules by polynuclear superhalogens more effective than that by mononuclear superhalogens? A high-level ab initio case study.

Science.gov (United States)

Li, Miao-Miao; Li, Jin-Feng; Bai, Hongcun; Sun, Yin-Yin; Li, Jian-Li; Yin, Bing

2015-08-21

The regulation of the electronic properties of organic molecules induced by polynuclear superhalogens is theoretically explored here for sixteen composite structures. It is clearly indicated by the higher vertical electron detachment energy (VDE) that polynuclear superhalogens are more effective in regulating the electronic properties than mononuclear structures. However, this enhanced regulation is not only determined by superhalogens themselves but also related to the distribution of the extra electron of the final composites. The composites, in which the extra electron is mainly aggregated into the superhalogen moiety, will possess higher VDE values, as reported in the case of C1', 7.12 eV at the CCSD(T) level. This is probably due to the fact that, compared with organic molecules, superhalogens possess stronger attraction towards the extra electron and thus should lead to lower energies of the extra electrons and to higher VDE values eventually. Compared with CCSD(T), the Outer Valence Green's Function (OVGF) method fails completely for composite structures containing Cl atoms, while MP2 results are generally consistent in terms of the relative order of VDEs. Actually if the extra electron distribution of the systems could be approximated by the HOMO, the results at the OVGF level will be consistent with the CCSD(T) results. Conversely, the difference in VDEs between OVGF and CCSD(T) is significantly large. Besides superhalogen properties, the structures, relative stabilities and thermodynamic stabilities with respect to various fragmentation channels were also investigated for all the composite structures.

Upholding science in health, safety and environmental risk assessments and regulations

International Nuclear Information System (INIS)

Aschner, Michael; Autrup, Herman N.; Berry, Sir Colin L.; Boobis, Alan R.; Cohen, Samuel M.; Creppy, Edmond E.; Dekant, Wolfgang; Doull, John; Galli, Corrado L.; Goodman, Jay I.; Gori, Gio B.; Greim, Helmut A.; Joudrier, Philippe

2016-01-01

A public appeal has been advanced by a large group of scientists, concerned that science has been misused in attempting to quantify and regulate unmeasurable hazards and risks. The appeal recalls that science is unable to evaluate hazards that cannot be measured, and that science in such cases should not be invoked to justify risk assessments in health, safety and environmental regulations. The appeal also notes that most national and international statutes delineating the discretion of regulators are ambiguous about what rules of evidence ought to apply. Those statutes should be revised to ensure that the evidence for regulatory action is grounded on the standards of the scientific method, whenever feasible. When independent scientific evidence is not possible, policies and regulations should be informed by publicly debated trade-offs between socially desirable uses and social perceptions of affordable precaution. This article explores the premises, implications and actions supporting the appeal and its objectives.

Lessons learned implementing environmental regulations at non-Department of Energy sites

International Nuclear Information System (INIS)

Craig, R.B.; Dippo, G.L.

1991-01-01

The Hazardous Waste Remedial Actions Program (HAZWRAP) has been involved in the implementation of environmental regulations at non-Department of Energy (DOE) facilities for > 5 years. If any common thread has been identified in working at these sites, it is that no two sites can be treated the same. Each site and its associated wastes, governing regulations, and environmental conditions are different. The list of technical lessons learned is long, and their applicability to other sites must be looked at for each specific case. That is far too large a task to undertake here. The most important lesson HAZWRAP learned is not technical. Implementing environmental regulations at non-DOE sites is not any different from implementing regulations or anything else done at DOE facilities. The key to success lies in quality, planning, and communication. Taking the time to implement a good quality program based on sound planning and open communication will ensure program success

Activity-regulated genes as mediators of neural circuit plasticity.

Science.gov (United States)

Leslie, Jennifer H; Nedivi, Elly

2011-08-01

Modifications of neuronal circuits allow the brain to adapt and change with experience. This plasticity manifests during development and throughout life, and can be remarkably long lasting. Evidence has linked activity-regulated gene expression to the long-term structural and electrophysiological adaptations that take place during developmental critical periods, learning and memory, and alterations to sensory map representations in the adult. In all these cases, the cellular response to neuronal activity integrates multiple tightly coordinated mechanisms to precisely orchestrate long-lasting, functional and structural changes in brain circuits. Experience-dependent plasticity is triggered when neuronal excitation activates cellular signaling pathways from the synapse to the nucleus that initiate new programs of gene expression. The protein products of activity-regulated genes then work via a diverse array of cellular mechanisms to modify neuronal functional properties. Synaptic strengthening or weakening can reweight existing circuit connections, while structural changes including synapse addition and elimination create new connections. Posttranscriptional regulatory mechanisms, often also dependent on activity, further modulate activity-regulated gene transcript and protein function. Thus, activity-regulated genes implement varied forms of structural and functional plasticity to fine-tune brain circuit wiring. Copyright © 2011 Elsevier Ltd. All rights reserved.

Transcriptional regulation of respiration in yeast metabolizing differently repressive carbon substrates

Directory of Open Access Journals (Sweden)

Fendt Sarah-Maria

2010-02-01

Full Text Available Abstract Background Depending on the carbon source, Saccharomyces cerevisiae displays various degrees of respiration. These range from complete respiration as in the case of ethanol, to almost complete fermentation, and thus very low degrees of respiration on glucose. While many key regulators are known for these extreme cases, we focus here on regulators that are relevant at intermediate levels of respiration. Results We address this question by linking the functional degree of respiration to transcriptional regulation via enzyme abundances. Specifically, we investigated aerobic batch cultures with the differently repressive carbon sources glucose, mannose, galactose and pyruvate. Based on 13C flux analysis, we found that the respiratory contribution to cellular energy production was largely absent on glucose and mannose, intermediate on galactose and highest on pyruvate. In vivo abundances of 40 respiratory enzymes were quantified by GFP-fusions under each condition. During growth on the partly and fully respired substrates galactose and pyruvate, several TCA cycle and respiratory chain enzymes were significantly up-regulated. From these enzyme levels and the known regulatory network structure, we determined the probability for a given transcription factor to cause the coordinated expression changes. The most probable transcription factors to regulate the different degrees of respiration were Gcr1p, Cat8p, the Rtg-proteins and the Hap-complex. For the latter three ones we confirmed their importance for respiration by quantifying the degree of respiration and biomass yields in the corresponding deletion strains. Conclusions Cat8p is required for wild-type like respiration, independent of its known activation of gluconeogenic genes. The Rtg-proteins and the Hap-complex are essential for wild-type like respiration under partially respiratory conditions. Under fully respiratory conditions, the Hap-complex, but not the Rtg-proteins are essential

Transcriptional regulation of respiration in yeast metabolizing differently repressive carbon substrates.

Science.gov (United States)

Fendt, Sarah-Maria; Sauer, Uwe

2010-02-18

Depending on the carbon source, Saccharomyces cerevisiae displays various degrees of respiration. These range from complete respiration as in the case of ethanol, to almost complete fermentation, and thus very low degrees of respiration on glucose. While many key regulators are known for these extreme cases, we focus here on regulators that are relevant at intermediate levels of respiration. We address this question by linking the functional degree of respiration to transcriptional regulation via enzyme abundances. Specifically, we investigated aerobic batch cultures with the differently repressive carbon sources glucose, mannose, galactose and pyruvate. Based on 13C flux analysis, we found that the respiratory contribution to cellular energy production was largely absent on glucose and mannose, intermediate on galactose and highest on pyruvate. In vivo abundances of 40 respiratory enzymes were quantified by GFP-fusions under each condition. During growth on the partly and fully respired substrates galactose and pyruvate, several TCA cycle and respiratory chain enzymes were significantly up-regulated. From these enzyme levels and the known regulatory network structure, we determined the probability for a given transcription factor to cause the coordinated expression changes. The most probable transcription factors to regulate the different degrees of respiration were Gcr1p, Cat8p, the Rtg-proteins and the Hap-complex. For the latter three ones we confirmed their importance for respiration by quantifying the degree of respiration and biomass yields in the corresponding deletion strains. Cat8p is required for wild-type like respiration, independent of its known activation of gluconeogenic genes. The Rtg-proteins and the Hap-complex are essential for wild-type like respiration under partially respiratory conditions. Under fully respiratory conditions, the Hap-complex, but not the Rtg-proteins are essential for respiration.

THE INFLUENCE OF PRIVACY REGULATION ON URBAN MALAY FAMILIES LIVING IN TERRACE HOUSING

OpenAIRE

Ahmad Hariza Hashim; Zaiton Abdul Rahim

2008-01-01

This paper reports on behavioral norms and territoriality as part of behavioral and environmental mechanisms used to regulate privacy among urban Malay families living in terrace housing. In-depth interview was employed involving 11 case studies of Malay families living in three-bedroom two-storey terrace housings in the urban areas. Findings indicate that while most of the behavioral norms employed to regulate privacy are consistent with Malay cultural norms and religious belief, there are a...

Regulating the Regulator

Energy Technology Data Exchange (ETDEWEB)

1992-08-26

The article reports on a challenge to the UK electricity regulator to defend his record by the Coalition for Fair Electricity Regulation (COFFER). The challenge centres on whether the obligation for the regional electric companies (REC) to purchase power from the cheapest source is being enforced. This is related to the wider issue of whether the REC's support of combined-cycle gas turbine (CCGT) is economic. COFFER considers that uneconomic gas-fired power plants are being allowed to displace economic coal-fired stations. Aspects discussed include the background to the dispute and the costs of CCGT and coal fired power generation. 1 fig., 1 tab.

Desirable changes in the legal radiation protection regulations in Austria

International Nuclear Information System (INIS)

Holeczke, F.

1988-01-01

The complexity of the Austrian Radiation Protection Law ranging from nuclear reactors up to odontoradiographs hampers its amendment so that merely an amendment of the Radiation Protection Ordinance seems to be feasible. Suggestions for amendments should orient themselves along experience made in practice. In particular amendments of the regulations on the period for safekeeping the records in radiodiagnostics, on the final examination of persons exposed to radiation in the case of termination of employment as well as of Sec. 34, 41 Subsec. 2 and Sec. 62, Subsec. 1 would be desirable. The latter concern technical regulations, the monitored area and the equipment for the soft-ray technique. (DG) [de

76 FR 77052 - Proposed Collection; Comment Request for Regulation Project

Science.gov (United States)

2011-12-09

... 1995, Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). The IRS is soliciting comments concerning... requires large banks to change from reserve method of accounting to the specific charge off method of accounting for bad debts. Section 1.585-8 of the regulation contains reporting requirements in cases in which...

Accounting window dressing and template regulation: A case study of the Australian credit union industry

NARCIS (Netherlands)

Hillier, D.; Hodgson, A.; Stevenson-Clarke, P.; Lhaopadchan, S.

2008-01-01

This article documents the response of cooperative institutions that were required to adhere to new capital adequacy regulations traditionally geared for profit-maximising organisations. Using data from the Australian credit union industry, we demonstrate that the cooperative philosophy and internal

The Impact of the Basel III Liquidity Regulations on the Bank Lending Channel: A Luxembourg case study

OpenAIRE

Gaston Giordana; Ingmar Schumacher

2011-01-01

In this paper we study the impact of the Basel III liquidity regulations, namely the Liquidity Coverage Ratio (LCR) and the Net Stable Funding Ratio (NSFR), on the bank lending channel in Luxembourg. For this aim we built, based on individual bank data, time series of the LCR and NSFR for a sample of banks covering between 82% and 100% of total assets of the banking sector. Additionally, we simulated the optimal balance sheet adjustments needed to adhere to the regulations. We extend the exis...

Regulations and financing for decommissioning of nuclear facilities

International Nuclear Information System (INIS)

Kumakura, Osamu

1981-01-01

The purpose of this report is to survey the French legislation concerning the decommissioning of nuclear facilities and the method of financing for it. There is no clause in French regulations, which states any specific criterion or licensing procedure for the proper decommissioning. The legal problems in this domain are treated within the general regulation system on atomic energy. The decommissioning of nuclear facilities is carried out in accordance with the licensing procedure for constructing nuclear facilities or the permission procedure for operating them, according to the ''Decree on nuclear installations, 1963''. The works for the final shut-down and decommissioning are regarded as the modification to the safety report or the general operation instructions, and new permit is required. In the case that the radioactivity of substances after decommissioning is above the criteria of the Decree, 1963, the new license is required. In the case of below the criteria, the facilities are governed by the ''Act on installations classified for environmental protection, 1976''. The ''Decree on general radiation protection, 1966'', the ''Decree on radiation protection of workers in nuclear installations, 1975'', the ''Ministerial order on transport of dangerous materials, 1945'', and two ministerial orders on radioactive effluent discharge, 1974, are applied to the decommissioning works. (Kako, I.)

The international radioactive transportation regulations: A model for national regulations

International Nuclear Information System (INIS)

Pope, R.B.; Rawl, R.R.

1990-06-01

The International Atomic Energy Agency's (IAEA) Regulations for the Safe Transport of Radioactive Material, Safety Series No. 6 (herein after denoted as the ''International Regulations'') serve as the model for the regulations for individual countries and international modal organizations controlling the packaging and transportation of radioactive materials. The purpose of this paper is to outline the background and history of the International Regulations, the general principles behind the requirements of the International Regulations, the structure and general contents of the latest edition of the International Regulations, and the roles of various international bodies in the development and implementation of the International Regulations and the current status of regulatory and supportive document development at both the international and domestic level. This review will provide a basis for users and potential users to better understand the source and application of the International Regulations. 1 tab

The Older Adult Positivity Effect in Evaluations of Trustworthiness: Emotion Regulation or Cognitive Capacity?

Science.gov (United States)

Zebrowitz, Leslie A; Boshyan, Jasmine; Ward, Noreen; Gutchess, Angela; Hadjikhani, Nouchine

2017-01-01

An older adult positivity effect, i.e., the tendency for older adults to favor positive over negative stimulus information more than do younger adults, has been previously shown in attention, memory, and evaluations. This effect has been attributed to greater emotion regulation in older adults. In the case of attention and memory, this explanation has been supported by some evidence that the older adult positivity effect is most pronounced for negative stimuli, which would motivate emotion regulation, and that it is reduced by cognitive load, which would impede emotion regulation. We investigated whether greater older adult positivity in the case of evaluative responses to faces is also enhanced for negative stimuli and attenuated by cognitive load, as an emotion regulation explanation would predict. In two studies, younger and older adults rated trustworthiness of faces that varied in valence both under low and high cognitive load, with the latter manipulated by a distracting backwards counting task. In Study 1, face valence was manipulated by attractiveness (low /disfigured faces, medium, high/fashion models' faces). In Study 2, face valence was manipulated by trustworthiness (low, medium, high). Both studies revealed a significant older adult positivity effect. However, contrary to an emotion regulation account, this effect was not stronger for more negative faces, and cognitive load increased rather than decreased the rated trustworthiness of negatively valenced faces. Although inconsistent with emotion regulation, the latter effect is consistent with theory and research arguing that more cognitive resources are required to process negative stimuli, because they are more cognitively elaborated than positive ones. The finding that increased age and increased cognitive load both enhanced the positivity of trustworthy ratings suggests that the older adult positivity effect in evaluative ratings of faces may reflect age-related declines in cognitive capacity rather

Sustainability Reporting in Fishing Industry Management - Regulation versus Voluntarism

Directory of Open Access Journals (Sweden)

Susan Wild

2008-09-01

Full Text Available A growing number of major corporations and industry organizations now overtly advocate thegeneral concept of corporate social and environmental responsibility, commonly emphasising the‘business case’ for such behaviour on the basis that it is ‘good for business’. Many now report totheir stakeholders on a voluntaristic basis a range of information regarding their impacts on thesocial and physical environment in which they operate.Intrinsic to the business case model is the argument that an optimal balance between the needs ofeconomic growth and the sustainable management of natural resources can best be attainedthrough the conventional mechanisms of corporate governance and voluntary corporate activity,rather than by imposition of governmental regulation. This view implies, however, that wherethe exigencies of environmental sustainability conflict with those of economic imperatives, thelatter must take precedence.A view oppositional to that of the business case instead promotes an intensified interventionistapproach towards natural resource management, advocating increased governmental regulationand control, including the mandating, standardization and independent verification of corporatesustainability reporting. This view gives precedence to public good concepts of natural resourcemanagement, prioritising intra- and inter-generational equity and human rights theories as tonatural resource distribution, and challenges traditional economic approaches to the relationalintersects of business, politics and environment science.This paper considers the relative claims for efficacy in achieving desirable corporateenvironmental behaviours of the business case and voluntary self-regulation model, vis-à-visthose for extended mandatory governmental control, utilizing the exemplar of voluntarysustainability reporting in the New Zealand fishing industry.

Banning, Blocking and Boosting: Twitter’s Solo-Regulation of Expression

Directory of Open Access Journals (Sweden)

Marko Milosavljević

2016-06-01

Full Text Available The regulation or self-regulation of online media is one of the key dilemmas of contemporary digital media and policy environment. This includes the new digital intermediary gatekeepers such as social media. The private rules of intermediaries, such as their ‘terms of service’ and content policies, importantly define their functioning and are sometimes thought of as self-regulatory mechanisms. Online intermediaries are increasingly being called upon to engage in codes of conduct or decisions about content. We focus on Twitter as one of the largest and most relevant new gatekeepers because of its use as source of news. The terms and other documents of Twitter are analysed as tools of self-regulation, and as the context within which the individual users and mass media (must function in today’s digital environment. We also look at how Twitter has applied this framework in two high profile cases.

Internet surveillance, regulation, and chilling effects online: a comparative case study

Directory of Open Access Journals (Sweden)

Jonathon W. Penney

2017-05-01

Full Text Available With internet regulation and censorship on the rise, states increasingly engaging in online surveillance, and state cyber-policing capabilities rapidly evolving globally, concerns about regulatory “chilling effects” online—the idea that laws, regulations, or state surveillance can deter people from exercising their freedoms or engaging in legal activities on the internet have taken on greater urgency and public importance. But just as notions of “chilling effects” are not new, neither is skepticism about their legal, theoretical, and empirical basis; in fact, the concept remains largely un-interrogated with significant gaps in understanding, particularly with respect to chilling effects online. This work helps fill this void with a first-of-its-kind online survey that examines multiple dimensions of chilling effects online by comparing and analyzing responses to hypothetical scenarios involving different kinds of regulatory actions—including an anti-cyberbullying law, public/private sector surveillance, and an online regulatory scheme, based on the Digital Millennium Copyright Act (DMCA, enforced through personally received legal threats/notices. The results suggest not only the existence and significance of regulatory chilling effects online across these different scenarios but also evidence a differential impact—with personally received legal notices and government surveillance online consistently having the greatest chilling effect on people’s activities online—and certain online activities like speech, search, and personal sharing also impacted differently. The results also offer, for the first time, insights based on demographics and other similar factors about how certain people and groups may be more affected than others, including findings that younger people and women are more likely to be chilled; younger people and women are less likely to take steps to resist regulatory actions and defend themselves; and anti

Self-Regulation Principles Underlying Risk Perception and Decision Making within the Context of Genomic Testing

Science.gov (United States)

Cameron, Linda D.; Biesecker, Barbara Bowles; Peters, Ellen; Taber, Jennifer M.; Klein, William M. P.

2017-01-01

Advances in theory and research on self-regulation and decision-making processes have yielded important insights into how cognitive, emotional, and social processes shape risk perceptions and risk-related decisions. We examine how self-regulation theory can be applied to inform our understanding of decision-making processes within the context of genomic testing, a clinical arena in which individuals face complex risk information and potentially life-altering decisions. After presenting key principles of self-regulation, we present a genomic testing case example to illustrate how principles related to risk representations, approach and avoidance motivations, emotion regulation, defensive responses, temporal construals, and capacities such as numeric abilities can shape decisions and psychological responses during the genomic testing process. We conclude with implications for using self-regulation theory to advance science within genomic testing and opportunities for how this research can inform further developments in self-regulation theory. PMID:29225669

Self-Regulation Principles Underlying Risk Perception and Decision Making within the Context of Genomic Testing.

Science.gov (United States)

Cameron, Linda D; Biesecker, Barbara Bowles; Peters, Ellen; Taber, Jennifer M; Klein, William M P

2017-05-01

Advances in theory and research on self-regulation and decision-making processes have yielded important insights into how cognitive, emotional, and social processes shape risk perceptions and risk-related decisions. We examine how self-regulation theory can be applied to inform our understanding of decision-making processes within the context of genomic testing, a clinical arena in which individuals face complex risk information and potentially life-altering decisions. After presenting key principles of self-regulation, we present a genomic testing case example to illustrate how principles related to risk representations, approach and avoidance motivations, emotion regulation, defensive responses, temporal construals, and capacities such as numeric abilities can shape decisions and psychological responses during the genomic testing process. We conclude with implications for using self-regulation theory to advance science within genomic testing and opportunities for how this research can inform further developments in self-regulation theory.

Self-regulation – the key to progress in clinical reasoning? | Postma ...

African Journals Online (AJOL)

Both groups lauded the scaffolding that the case-based curriculum provided. Strategic thinking, goal orientation and self-regulation ability were identified in group 1. A lack of diligence, poor data-processing ability and a possible lack of interest were identified in group 2 students, who were unaware of learning opportunities.

New technologies to meet regulations

International Nuclear Information System (INIS)

Frank, C.; Harmon, L.

1991-01-01

The US Department of Energy's (DOE's) Office of Environmental Restoration and Waste Management has set the ambitious goal of having all of its facilities cleaned up and in compliance with applicable environmental laws and regulations by the year 2019. This goal is ambitious both because of the magnitude of the effort required and because, in many cases, the means for attaining the goal do not now exist. The DOE's strategy for reaching its goal is based on applied research and development, education, and cooperation with regulators. The Office of Technology Development (OTD) within the Office of Environmental Restoration and Waste Management has instituted a program to assess the magnitude of the cleanup effort and to evaluate the potential technologies to be used. The OTD has program responsibility for providing new and more effective technologies for meeting DOE's goal for compliance and cleanup. Included are research and development of new technologies; demonstration, testing, and evaluation of technologies developed elsewhere; transportation; and educational programs to produce the scientists and engineers needed to maintain the momentum of research, development, demonstration, testing, and evaluation (RDDT and E) until the job is complete

APRILab: Regulation Dilemma in South Harbor & Aalborg East, Denmark

DEFF Research Database (Denmark)

Hansen, Jesper Rohr

Copenhagen [in English, ‘South Harbour’] demonstrates an urban periphery development that in terms of strategy formation, project development and implementation has been running since the late 1990s. Accordingly, most of the city district of Sydhavn Copenhagen has been planned for. However, despite...... is the financial crisis that paralyzed the development in the area in the years 2007-2011; however, as this report shows, the deployment of new regulative tools as well as an expansionist municipal growth strategy have also contributed to this slow progress, generating problems of cooperation between landowners...... and diverting the attention and resources of the municipal system (administratively, politically). The suburban case, Aalborg Øst [in English, ‘Aalborg East’], in the City of Aalborg, is another type of case completely. This case is immature in the sense that only the first building blocks for a strategy...

Self-regulated learning strategies used in surgical clerkship and the relationship with clinical achievement.

Science.gov (United States)

Turan, Sevgi; Konan, Ali

2012-01-01

Self-regulated learning indicates students' skills in controlling their own learning. Self-regulated learning, which a context-specific process, emphasizes autonomy and control. Students gain more autonomy with respect to learning in the clinical years. Examining the self-regulated learning skills of students in this period will provide important clues about the level at which students are ready to use these skills in real-life conditions. The self-regulated learning strategies used by medical students in surgical clerkship were investigated in this study and their relation with clinical achievement was analyzed. The study was conducted during the surgery clerkship of medical students. The participation rate was 94% (309 students). Motivated Strategies for Learning Questionnaire (MSLQ), a case-based examination, Objective Structured Clinical Examination (OSCE), and tutor evaluations for assessing achievement were used. The relationship between the Motivated Strategies for Learning Questionnaire scores of the students and clinical achievement was analyzed with multilinear regression analysis. The findings showed that students use self-regulated learning skills at medium levels during their surgery clerkship. A relationship between these skills and OSCE scores and tutor evaluations was determined. OSCE scores of the students were observed to increase in conjunction with increased self-efficacy levels. However, as students' beliefs regarding control over learning increased, OSCE scores decreased. No significant relationship was defined between self-regulated learning skills and case-based examination scores. We observed that a greater self-efficacy for learning resulted in higher OSCE scores. Conversely, students who believe that learning is a result of their own effort had lower OSCE scores. Copyright © 2012 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

31 CFR 357.30 - Cases of delay or suspension of payment.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Cases of delay or suspension of payment. 357.30 Section 357.30 Money and Finance: Treasury Regulations Relating to Money and Finance... Securities System (Legacy Treasury Direct) § 357.30 Cases of delay or suspension of payment. If evidence...

Regulation and development of the Argentinean gas market

International Nuclear Information System (INIS)

Ponzo, Ricardo; Dyner, Isaac; Arango, Santiago; Larsen, Erik R.

2011-01-01

Gas markets are becoming increasingly important around the world and the long-term evolution of these markets is of strategic importance for many countries. This makes it essential to understand how regulation and intervention in these markets affects the long-term prospect for the secure supply of gas. We use Argentina as a case to illustrate some of the issues and consequences of gas regulation. Argentina is a country that has had a significant increase in the use of gas over the years, and where a potential gas deficit looms large in the present and the future. Based on a simulation model developed to understand the supply of gas in Argentina, we discuss how regulation will influence the long-term supply of gas in both Argentina and surrounding countries. Using the model, we develop a series of scenarios to highlight the consequences of different current and possible future interventions in the market by the Regulator. Finally, we discuss short-term regulatory options to reduce the impact of a gas deficit, and the possibility of securing the long-term supply of gas in Argentina. - Research Highlights: →This study show that even short intervention in markets can have long term impact. →Simulation can help to understand the evolution of the Argentinean gas markets. →Scenarios highlight the gas shortage.

The precautionary principle and regulation of chemicals

DEFF Research Database (Denmark)

Løkke, Søren

This dissertation presents a combined approach to the study of discourse and technology. The approach is applied on two different cases involving the precautionary principle and chemicals; namely an in-depth analysis of a short-lived prohibition against a specific class of pesticides based...... on conflicting sciences, and a broader analysis of the development of chemicals regulation and the interrelation to the precautionary principle. It is concluded that the precautionary principle in practise requires a vivid debate at all levels including scientific approaches and public deliberation....

The development of safety cases for healthcare services: Practical experiences, opportunities and challenges

International Nuclear Information System (INIS)

Sujan, Mark; Spurgeon, Peter; Cooke, Matthew; Weale, Andy; Debenham, Philip; Cross, Steve

2015-01-01

There has been growing interest in the concept of safety cases for medical devices and health information technology, but questions remain about how safety cases can be developed and used meaningfully in the safety management of healthcare services and processes. The paper presents two examples of the development and use of safety cases at a service level in healthcare. These first practical experiences at the service level suggest that safety cases might be a useful tool to support service improvement and communication of safety in healthcare. The paper argues that safety cases might be helpful in supporting healthcare organisations with the adoption of proactive and rigorous safety management practices. However, it is also important to consider the different level of maturity of safety management and regulatory oversight in healthcare. Adaptations to the purpose and use of safety cases might be required, complemented by the provision of education to both practitioners and regulators. - Highlights: • Empirical description of safety case development at service level in healthcare. • Safety cases can support adoption of proactive and rigorous safety management. • Adaptation to purpose and use of safety cases might be required in healthcare. • Education should be provided to practitioners and regulators

Corporate-NGO partnerships as a form of civil regulation: lessons from the energy biodiversity initiative

OpenAIRE

Stephen Tully

2004-01-01

This paper will assess the prospects of so-called 'civil' regulation, or the ability of non-governmental organisations (NGOs), to regulate commercial behaviour within the institutional setting of a partnership. The selected case study involves an initiative between five conservation NGOs and five energy firms seeking to integrate biodiversity considerations into upstream oil and gas development projects within, or adjacent to, environmentally-sensitive or protected areas. Part one describes t...

Parallel journeys: Adam Smith and Milton Friedman on the regulation of banking

OpenAIRE

Rockoff, Hugh

2010-01-01

Adam Smith and Milton Friedman are famous for championing Laissez Faire, yet both supported government regulation of the banking system. In both cases their deviation from free market orthodoxy was based on a careful reading of financial history: especially Smith's reading of the Crisis of 1772 and Friedman's reading of the Crisis of 1929-33. In both cases they based their reading on a complex and nuanced account of human nature. This paper describes their parallel journeys to the conclusion ...

Characterizing complexity in socio-technical systems: a case study of a SAMU Medical Regulation Center.

Science.gov (United States)

Righi, Angela Weber; Wachs, Priscila; Saurin, Tarcísio Abreu

2012-01-01

Complexity theory has been adopted by a number of studies as a benchmark to investigate the performance of socio-technical systems, especially those that are characterized by relevant cognitive work. However, there is little guidance on how to assess, systematically, the extent to which a system is complex. The main objective of this study is to carry out a systematic analysis of a SAMU (Mobile Emergency Medical Service) Medical Regulation Center in Brazil, based on the core characteristics of complex systems presented by previous studies. The assessment was based on direct observations and nine interviews: three of them with regulator of emergencies medical doctor, three with radio operators and three with telephone attendants. The results indicated that, to a great extent, the core characteristics of complexity are magnified) due to basic shortcomings in the design of the work system. Thus, some recommendations are put forward with a view to reducing unnecessary complexity that hinders the performance of the socio-technical system.

Primary frequency regulation with Li-ion battery energy storage system: A case study for Denmark

DEFF Research Database (Denmark)

Swierczynski, Maciej Jozef; Stroe, Daniel Ioan; Stan, Ana-Irina

2013-01-01

Meeting ambitious goals of transition to distributed and environmentally-friendly renewable energy generation can be difficult to achieve without energy storage systems due to technical and economical challenges. Moreover, energy storage systems have a high potential of not only smoothing and imp...... electricity market. Moreover, in this paper a possible improvement of the Li-ion BESS energy management strategy is shown, which allows for obtaining the higher NPV....... lifetime, which introduces significant risk into the business model. This paper deals with the investigation of the lifetime of LiFeP04/C battery systems when they are used to provide primary frequency regulation service. A semi-empirical lifetime model for these battery cells was developed based...... on the results obtained from accelerated lifetime testing. The developed Li­-ion battery lifetime model is later a base for the analyses of the economic profitability of the investment in the Li-ion battery energy storage system (BESS), which delivers the primary frequency regulation service on the Danish...

The Liability of the Managing Body within the Insolvency Proceedings in Romania: Case-Law Study

Directory of Open Access Journals (Sweden)

Rodica Diana Apan

2015-11-01

Full Text Available The study aims at identifying the new elements that the Insolvency Code in Romania, Law 85 of 2014, brings in what concerns entailing the liability of the managing body as well as that of other persons having contributed to the debtor's state of insolvency, compared to the previous regulation provided by Law 85 of 2006. The identification of these elements is carried out by making reference to the types of deeds that, following taken legal action, can entail liability and the coverage of the debts by the members of the managing body as well as by other persons having contributed to the debtor's state of insolvency. The analysis of the deeds concentrates around two connected centers of interest: The analysis of the deeds such as they are regulated by the two regulations and the case where for certain deeds there need to be identified the elements of repeatability in the two regulations and then the relevant case-law applicable for the respective deed is analyzed. In conclusion, in this way are identified the case-law variations met by the regulations applicable to the respective deed, in the judgments grounded on Law 85 of 2006. These variations represent landmarks for the regulations comprised by the Romanian Insolvency Code – Law 85 of 2014. Following the analyzed legal precedents – a number of 30 case-law judgments issued by courts of appeal being at the highest level of jurisdiction, there are identified in concreto, the type of acts which may entail the liability of the managing body for the insolvency of the enterprise. Through the present study we aim to guide the local administrators, as well as the future foreign investors who engage in foreign direct investments (FDI in Romania with regard to the liability of the managing body in within the insolvency proceedings.

A case series of patients using medicinal marihuana for management of chronic pain under the Canadian Marihuana Medical Access Regulations.

Science.gov (United States)

Lynch, Mary E; Young, Judee; Clark, Alexander J

2006-11-01

The Canadian Marihuana Medical Access Regulations (MMAR) program allows Health Canada to grant access to marihuana for medical use to those who are suffering from grave and debilitating illnesses. This is a report on a case series of 30 patients followed at a tertiary care pain management center in Nova Scotia who have used medicinal marihuana for 1-5 years under the MMAR program. Patients completed a follow-up questionnaire containing demographic and dosing information, a series of 11-point numerical symptom relief rating scales, a side effect checklist, and a subjective measure of improvement in function. Doses of marihuana ranged from less than 1 to 5g per day via the smoked or oral route of administration. Ninety-three percent of patients reported moderate or greater pain relief. Side effects were reported by 76% of patients, the most common of which were increased appetite and a sense of well-being, weight gain, and slowed thoughts. Limitations of the study include self-selection bias, small size, and lack of a control group. The need for further study using controlled trials is discussed along with an overview of the MMAR program.

Guide to a Strategic Procurement Planning Approach on Regulated Commodity Markets

Science.gov (United States)

Seifert, Marcus; Wüst, Thorsten

The access of Virtual Organizations to raw materials normally requires external resources. In many cases, the market for raw materials is regulated and the VO principles of trust, customer orientation etc. are not applicable. In consequence, the VO needs to provide reliable solutions for the customer while being dependent on the access to the required raw materials. The objective of the proposed paper is to present a guide to a strategic procurement planning for the manufacturing industry on regulated commodity markets. This guide can be used to evaluate specific sourcing options. The main goal of this guide is to identify the negative effects of market regulation at an early stage and reduce them by developing strategic alternatives. The successful application of this guide is demonstrated by the practical example of the refractory industry and one of their commodities, refractory grade bauxite.

The Impact of Regulating Social Science Research with Biomedical Regulations

Science.gov (United States)

Durosinmi, Brenda Braxton

2011-01-01

The Impact of Regulating Social Science Research with Biomedical Regulations Since 1974 Federal regulations have governed the use of human subjects in biomedical and social science research. The regulations are known as the Federal Policy for the Protection of Human Subjects, and often referred to as the "Common Rule" because 18 Federal…

Whistleblowing in the Slovak labor law regulation

Directory of Open Access Journals (Sweden)

Daniel Krošlák

2015-12-01

Full Text Available Corrupt behaviour is a common practice with negative effects on the whole of society. For instance, if a company wins a public procurement contract in an unfair way, it enriches itself not only at the expense of competition, but also at the expense of the whole of society, as the best applicant has not necessarily been selected within such a procurement. The same applies in the case of a supplier launching an unsafe product onto the market, threatening the health of everyone who buys it. In order to prevent such malpractice and eliminate their negative effects, the cooperation of persons aware of such behaviours is necessary. In order to ensure such cooperation, however, the existence of instruments protecting whistle-blowers against various sanctions (especially by employers is necessary. As Slovak legislation did not include a regulation of procedures for reporting malpractice and protecting whistle-blowers, a new law aimed at solving such issues was enacted in October, 2014. The given legal regulation took effect on January 1, 2015. This paper endeavours to provide basic knowledge of the environment that the given regulation entered, as well as information on the possibilities of individuals to protect social interests on its grounds.

Non-Cooperative Regulation Coordination Based on Game Theory for Wind Farm Clusters during Ramping Events

DEFF Research Database (Denmark)

Qi, Yongzhi; Liu, Yutian; Wu, Qiuwei

2017-01-01

With increasing penetration of wind power in power systems, it is important to track scheduled wind power output as much as possible during ramping events to ensure security of the system. In this paper, a non‐cooperative coordination strategy based on the game theory is proposed for the regulation...... of the regulation revenue function according to the derived Nash equilibrium condition, the ER strategy is the Nash equilibrium of the regulation competition. Case studies were conducted with the power output data of wind farms from State Grid Jibei Electric Power Company Limited of China to demonstrate...

Studying gene regulation in methanogenic archaea.

Science.gov (United States)

Rother, Michael; Sattler, Christian; Stock, Tilmann

2011-01-01

Methanogenic archaea are a unique group of strictly anaerobic microorganisms characterized by their ability, and dependence, to convert simple C1 and C2 compounds to methane for growth. The major models for studying the biology of methanogens are members of the Methanococcus and Methanosarcina species. Recent development of sophisticated tools for molecular analysis and for genetic manipulation allows investigating not only their metabolism but also their cell cycle, and their interaction with the environment in great detail. One aspect of such analyses is assessment and dissection of methanoarchaeal gene regulation, for which, at present, only a handful of cases have been investigated thoroughly, partly due to the great methodological effort required. However, it becomes more and more evident that many new regulatory paradigms can be unraveled in this unique archaeal group. Here, we report both molecular and physiological/genetic methods to assess gene regulation in Methanococcus maripaludis and Methanosarcina acetivorans, which should, however, be applicable for other methanogens as well. Copyright © 2011 Elsevier Inc. All rights reserved.

To Regulate or Not to Regulate? Views on Electronic Cigarette Regulations and Beliefs about the Reasons for and against Regulation.

Science.gov (United States)

Sanders-Jackson, Ashley; Tan, Andy S L; Bigman, Cabral A; Mello, Susan; Niederdeppe, Jeff

2016-01-01

Policies designed to restrict marketing, access to, and public use of electronic cigarettes (e-cigarettes) are increasingly under debate in various jurisdictions in the US. Little is known about public perceptions of these policies and factors that predict their support or opposition. Using a sample of US adults from Amazon Mechanical Turk in May 2015, this paper identifies beliefs about the benefits and costs of regulating e-cigarettes and identifies which of these beliefs predict support for e-cigarette restricting policies. A higher proportion of respondents agreed with 8 different reasons to regulate e-cigarettes (48.5% to 83.3% agreement) versus 7 reasons not to regulate e-cigarettes (11.5% to 18.9%). The majority of participants agreed with 7 out of 8 reasons for regulation. When all reasons to regulate or not were included in a final multivariable model, beliefs about protecting people from secondhand vapor and protecting youth from trying e-cigarettes significantly predicted stronger support for e-cigarette restricting policies, whereas concern about government intrusion into individual choices was associated with reduced support. This research identifies key beliefs that may underlie public support or opposition to policies designed to regulate the marketing and use of e-cigarettes. Advocates on both sides of the issue may find this research valuable in developing strategic campaigns related to the issue. Specific beliefs of potential benefits and costs of e-cigarette regulation (protecting youth, preventing exposure to secondhand vapor, and government intrusion into individual choices) may be effectively deployed by policy makers or health advocates in communicating with the public.

To Regulate or Not to Regulate? Views on Electronic Cigarette Regulations and Beliefs about the Reasons for and against Regulation.

Directory of Open Access Journals (Sweden)

Ashley Sanders-Jackson

Full Text Available Policies designed to restrict marketing, access to, and public use of electronic cigarettes (e-cigarettes are increasingly under debate in various jurisdictions in the US. Little is known about public perceptions of these policies and factors that predict their support or opposition.Using a sample of US adults from Amazon Mechanical Turk in May 2015, this paper identifies beliefs about the benefits and costs of regulating e-cigarettes and identifies which of these beliefs predict support for e-cigarette restricting policies.A higher proportion of respondents agreed with 8 different reasons to regulate e-cigarettes (48.5% to 83.3% agreement versus 7 reasons not to regulate e-cigarettes (11.5% to 18.9%. The majority of participants agreed with 7 out of 8 reasons for regulation. When all reasons to regulate or not were included in a final multivariable model, beliefs about protecting people from secondhand vapor and protecting youth from trying e-cigarettes significantly predicted stronger support for e-cigarette restricting policies, whereas concern about government intrusion into individual choices was associated with reduced support.This research identifies key beliefs that may underlie public support or opposition to policies designed to regulate the marketing and use of e-cigarettes. Advocates on both sides of the issue may find this research valuable in developing strategic campaigns related to the issue.Specific beliefs of potential benefits and costs of e-cigarette regulation (protecting youth, preventing exposure to secondhand vapor, and government intrusion into individual choices may be effectively deployed by policy makers or health advocates in communicating with the public.

Regulations and instructions for RA reactor operation; Propisi i uputstva za pogon reaktora 'A'

Energy Technology Data Exchange (ETDEWEB)

NONE

1989-07-01

This regulatory guide consists of following 4 chapters: Description of the RA reactor, organization scheme, regulations for performing experiments; Regulations for staff on duty; Instructions for operating the vacuum systems, heavy water and helium systems; and evacuation in case of accident. [Serbo-Croat] Ovaj pravilnik sadrzi sledeca 4 poglavlja: Opis reaktora RA, sema organizacije rada, propisi za izvodjenje eksperimenata; Pravilnik za rad dezurnog osoblja; Uputstva za rada sa vakuum sistemima, sistemom teske vode, sistemom helijuma; evakuacija u slucaju udesa.

Cystic fibrosis: case report

International Nuclear Information System (INIS)

Park, Si Hyun; Lee, Hyun Ju; Kim, Ji Hye; Park, Chol Heui

2002-01-01

Cystic fibrosis is an autosomal recessive genetic disease. Among Caucasians, it is the most common cause of pulmonary insufficiency during the first three decades of life. The prevalence of cystic fibrosis varies according to ethnic origin: it is common among Caucasians but rare among Asians. We report a case in which cystic fibrosis with bronchiectasis and hyperaeration was revealed by high-resolution CT, and mutation of the cystic fibrosis conductance transmembrane regulator gene (CFTR) by DNA analysis

Cystic fibrosis: case report

International Nuclear Information System (INIS)

Park, Si Hyun; Lee, Hyun Ju; Kim, Ji Hye; Park, Chol Heui

2002-01-01

Cystic fibrosis is a autosomal recessive genetic disease. Among caucasians, it is the most common cause of pulmonary insufficiency during the first three decades of life. The prevalence of cystic fibrosis varies according to ethnic origin: it is common among caucasians but rare among Asians. We report a case in which cystic fibrosis with bronchiectasis and hyperaeration was revealed by high-resolution CT, and mutation of the cystic fibrosis conductance transmembrane regulator gene (CFTR) by DNA analysis

The UK system for regulating the long-term safety of radioactive waste disposal

International Nuclear Information System (INIS)

Duncan, A.

1997-01-01

The general system is described for regulation of disposal of solid, long-lived radioactive wastes. The relevant Government policy is outlined, and the framework of legislation and arrangements for implementation, the associated guidance produced by regulatory bodies and the approach to assessment by regulators of a safety case for radioactive waste disposal are reported. Also, for the purposes of discussion in the Workshop, some of the practical issues are considered which are still in development in the UK in regard to regulatory methodology. (author)

Mechanisms of the Regulation of the Intestinal Na+/H+ Exchanger NHE3

Directory of Open Access Journals (Sweden)

Peijian He

2010-01-01

Full Text Available A major of Na+ absorptive process in the proximal part of intestine and kidney is electroneutral exchange of Na+ and H+ by Na+/H+ exchanger type 3 (NHE3. During the past decade, significant advance has been achieved in the mechanisms of NHE3 regulation. A bulk of the current knowledge on Na+/H+ exchanger regulation is based on heterologous expression of mammalian Na+/H+ exchangers in Na+/H+ exchanger deficient fibroblasts, renal epithelial, and intestinal epithelial cells. Based on the reductionist's approach, an understanding of NHE3 regulation has been greatly advanced. More recently, confirmations of in vitro studies have been made using animals deficient in one or more proteins but in some cases unexpected findings have emerged. The purpose of this paper is to provide a brief overview of recent progress in the regulation and functions of NHE3 present in the luminal membrane of the intestinal tract.

Ethical issues in engineering design processes ; regulative frameworks for safety and sustainability

NARCIS (Netherlands)

Gorp, A. van

2007-01-01

The ways designers deal with ethical issues that arise in their consideration of safety and sustainability in engineering design processes are described. In the case studies, upon which this article is based, a difference can be seen between normal and radical design. Designers refer to regulative

Regulation of nuclear power: the case of the light water reactor

International Nuclear Information System (INIS)

Rolph, E.

1977-06-01

This report is one of a series of documents that trace the history of the development and commercialization of the light water reactor in the expectation that a better appreciation of the development and commercialization process of this complex technology could be instructive in understanding the regulatory and economic obstacles currently slowing diffusion of that technology and the problems that may be encountered in similar large-scale, high-technology development projects. This regulatory history of the Atomic Energy Commission chronicles the significant events between 1954, when the AEC was given responsibility for regulating nuclear power plants, and 1974, when the AEC was absorbed by the Energy Research and Development Administration and the Nuclear Regulatory Commission. It identifies the origins of regulatory problems that have arisen during the period and describes how the AEC dealt with them. The history is based, for the most part, on primary source documents: hearings, news reports, and AEC documents

Latinamerican, Mercosur and imported countries regulations

Directory of Open Access Journals (Sweden)

Jacqueline Cea

2011-04-01

's population, were known to have specific mycotoxin regulations in 2003.Compared to other regions of the world, Europe has the most extensive and detailed regulations for mycotoxins in food. It is of interest to note that many of the EU candidate member countries have mycotoxin regulations, which are often more detailed than those currently in force in the EU. Comparing the situation in 1995 and 2003, it appears that in 2003 more mycotoxins are regulated in more commodities and products, whereas tolerance limits generally remain the same or tend to decrease.Whereas harmonized tolerance limits would be beneficial from the point of view of trade, this would not necessarily be the case from the point of view of (equal human health protection around the world. Risks associated with mycotoxins depend on both hazard and exposure. The hazard of mycotoxins to individuals is probably more or less the same all over the world .Exposure is not the same because of differences in levels of contamination and dietary habits in various parts of the world. National governments or regional communities should encourage and fund activities that contribute to reliable exposure assessment of mycotoxins in their regions.(FAO Food and Nutrition paper 81

Considerations regarding the general rule provided by the article 4 of the Rome II regulation

Directory of Open Access Journals (Sweden)

Adrian PRICOPI

2010-12-01

Full Text Available This article addresses certain issues related to the enforcement of the Rome II Regulation. The mentioned Regulation was adopted in order to unify, within the European Union, the rules regarding choice of law concerning non-contractual obligations. The application of the Regulation has caused some controversies in jurisprudence, regarding the implications on the national laws and international treaties or conventions. Almost two years after its prescribed date of application, a rigorous analysis of the Regulation’s impact over the case law, both on national and European level is necessary. The purpose of this study is to briefly describe, the research of the two authors regarding the practical effects of the aforementioned Regulation, as well as some judicial problems arisen from its application, mainly relating to the general rule of law, expressed in the fourth Article of the Regulation.

7 CFR 301.89-5 - Movement of regulated articles from regulated areas.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Movement of regulated articles from regulated areas. 301.89-5 Section 301.89-5 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL... § 301.89-5 Movement of regulated articles from regulated areas. (a) Any regulated article may be moved...

MP-GeneticSynth: inferring biological network regulations from time series.

Science.gov (United States)

Castellini, Alberto; Paltrinieri, Daniele; Manca, Vincenzo

2015-03-01

MP-GeneticSynth is a Java tool for discovering the logic and regulation mechanisms responsible for observed biological dynamics in terms of finite difference recurrent equations. The software makes use of: (i) metabolic P systems as a modeling framework, (ii) an evolutionary approach to discover flux regulation functions as linear combinations of given primitive functions, (iii) a suitable reformulation of the least squares method to estimate function parameters considering simultaneously all the reactions involved in complex dynamics. The tool is available as a plugin for the virtual laboratory MetaPlab. It has graphical and interactive interfaces for data preparation, a priori knowledge integration, and flux regulator analysis. Availability and implementation: Source code, binaries, documentation (including quick start guide and videos) and case studies are freely available at http://mplab.sci.univr.it/plugins/mpgs/index.html. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Sex Work Regulation and Sexually Transmitted Infections in Tijuana, Mexico.

Science.gov (United States)

Quast, Troy; Gonzalez, Fidel

2017-05-01

While reducing the transmission of sexually transmitted infections is a common argument for regulating sex work, relatively little empirical evidence is available regarding the effectiveness of these policies. We investigate the effects of highly publicized sex work regulations introduced in 2005 in Tijuana, Mexico on the incidence of trichomoniasis. State-level, annual data for the 1995-2012 period are employed that include the incidence rates of trichomoniasis by age group and predictor variables. We find that the regulations led to a decrease in the incidence rate of trichomoniasis. Specifically, while our estimates are somewhat noisy, the all-ages incidence rate in the 2005-2012 period is roughly 37% lower than what is predicted by our synthetic control estimates and corresponds to approximately 800 fewer reported cases of trichomoniasis per year. We find that the decreases are especially pronounced for 15-24 and 25-44 age cohorts. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

76 FR 52139 - Defense Federal Acquisition Regulation Supplement; Government; Property (DFARS Case 2009-D008)

Science.gov (United States)

2011-08-19

... responsibility for compliance with export control law and regulations a ``due diligence responsibility.'' DoD... clearance officer suspects data integrity issues; however, 245.602-1(2) has been clarified to specify... that the supplier name and part number be required for all items in Federal condition code A1 being...

Environmental regulation in a network of simulated microbial ecosystems.

Science.gov (United States)

Williams, Hywel T P; Lenton, Timothy M

2008-07-29

The Earth possesses a number of regulatory feedback mechanisms involving life. In the absence of a population of competing biospheres, it has proved hard to find a robust evolutionary mechanism that would generate environmental regulation. It has been suggested that regulation must require altruistic environmental alterations by organisms and, therefore, would be evolutionarily unstable. This need not be the case if organisms alter the environment as a selectively neutral by-product of their metabolism, as in the majority of biogeochemical reactions, but a question then arises: Why should the combined by-product effects of the biota have a stabilizing, rather than destabilizing, influence on the environment? Under certain conditions, selection acting above the level of the individual can be an effective adaptive force. Here we present an evolutionary simulation model in which environmental regulation involving higher-level selection robustly emerges in a network of interconnected microbial ecosystems. Spatial structure creates conditions for a limited form of higher-level selection to act on the collective environment-altering properties of local communities. Local communities that improve their environmental conditions achieve larger populations and are better colonizers of available space, whereas local communities that degrade their environment shrink and become susceptible to invasion. The spread of environment-improving communities alters the global environment toward the optimal conditions for growth and tends to regulate against external perturbations. This work suggests a mechanism for environmental regulation that is consistent with evolutionary theory.

Co-regulation in EU personal data protection : The case of technical standards and the privacy by design standardisation ‘mandate’

NARCIS (Netherlands)

Kamara, Irene

The recently adopted General Data Protection Regulation (GDPR), a technology-neutral law, endorses self-regulatory instruments, such as certification and technical standards. Even before the adoption of the General Data Protection Regulation, standardisation activity in the field of privacy

Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation

DEFF Research Database (Denmark)

Csikász-Nagy, Attila; Kapuy, Orsolya; Tóth, Attila

2009-01-01

of these EPs. From genome-scale data sets of budding yeast, we identify 126 EPs that are regulated by Cdk1 both through direct phosphorylation of the EP and through phosphorylation of the transcription factors that control expression of the EP, so that each of these EPs is regulated by a feed-forward loop (FFL......) from Cdk1. By mathematical modelling, we show that such FFLs can activate EPs at different phases of the cell cycle depending of the effective signs (+ or -) of the regulatory steps of the FFL. We provide several case studies of EPs that are controlled by FFLs exactly as our models predict. The signal...

Using Self-Regulated Learning Methods to Increase Native American College Retention

Science.gov (United States)

Patterson, David A.; Ahuna, Kelly H.; Tinnesz, Christine Gray; Vanzile-Tamsen, Carol

2014-01-01

A big challenge facing colleges and university programs across the United States is retaining students to graduation. This is especially the case for Native American students, who have had one of the highest dropout rates over the past several decades. Using data from a large university that implemented a self-regulated learning course for…

[Regulation of terpene metabolism

Energy Technology Data Exchange (ETDEWEB)

Croteau, R.

1991-01-01

During the last grant period, we have completed studies on the key pathways of monoterpene biosynthesis and catabolism in sage and peppermint, and have, by several lines of evidence, deciphered the rate-limiting step of each pathway. We have at least partially purified and characterized the relevant enzymes of each pathway. We have made a strong case, based on analytical, in vivo, and in vitro studies, that terpene accumulation depends upon the balance between biosynthesis and catabolism, and provided supporting evidence that these processes are developmentally-regulated and very closely associated with senescence of the oil glands. Oil gland ontogeny has been characterized at the ultrastructural level. We have exploited foliar-applied bioregulators to delay gland senescence, and have developed tissue explant and cell culture systems to study several elusive aspects of catabolism. We have isolated pure gland cell clusters and localized monoterpene biosynthesis and catabolism within these structures, and have used these preparations as starting materials for the purification to homogeneity of target regulatory'' enzymes. We have thus developed the necessary background knowledge, based on a firm understanding of enzymology, as well as the necessary experimental tools for studying the regulation of monoterpene metabolism at the molecular level. Furthermore, we are now in a position to extend our systematic approach to other terpenoid classes (C[sub 15]-C[sub 30]) produced by oil glands.

75 FR 71564 - Defense Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS...

Science.gov (United States)

2010-11-24

... Federal Acquisition Regulation Supplement; Contractor Insurance/Pension Review (DFARS Case 2009-D025... conducting a Contractor Insurance/Pension Review from Procedures, Guidance, and Information (PGI) to the... This final rule relocates requirements for Contractor Insurance/ Pension Review to DFARS 242.7302 from...

76 FR 28855 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration

Science.gov (United States)

2011-05-18

...; Business Systems-- Definition and Administration; Interim Rule #0;#0;Federal Register / Vol. 76 , No. 96...-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration... an initial proposed rule for Business Systems-- Definition and Administration (DFARS Case 2009-D038...

75 FR 54524 - Defense Federal Acquisition Regulation Supplement; Acquisition Strategies To Ensure Competition...

Science.gov (United States)

2010-09-08

...., because the changes are to internal Government organization and operating procedures only. The rule... 48 CFR Part 207 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations... Life Cycle of Major Defense Acquisition Programs (DFARS Case 2009-D014) AGENCY: Defense Acquisition...

76 FR 11414 - Defense Federal Acquisition Regulation Supplement; Independent Research and Development Technical...

Science.gov (United States)

2011-03-02

... Acquisition Regulation Supplement; Independent Research and Development Technical Descriptions (DFARS Case... (DFARS) to require contractors to report independent research and development (IR&D) projects generating... to the Defense Technical Information Center (DTIC). Beginning in the 1990s, DoD reduced its technical...

8 CFR 287.3 - Disposition of cases of aliens arrested without warrant.

Science.gov (United States)

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Disposition of cases of aliens arrested without warrant. 287.3 Section 287.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS FIELD OFFICERS; POWERS AND DUTIES § 287.3 Disposition of cases of aliens arrested without warrant...

2014 Annual Report of Chapter VI of the Staff Rules and Regulations (Settlement of disputes and discipline) - HR Department

CERN Document Server

Barbin, Lucie; CERN. Geneva. HR Department

2015-01-01

The 2014 Annual Report under Chapter VI ("Settlement of Disputes and Discipline") of the Staff Rules and Regulations (SRR) serves to report cases of submission of requests for review, internal appeals, complaints with the ILOAT, and cases in which disciplinary action was taken.

Regulation for the accomplishment of public purposes: the case of public utilities in Colombia

OpenAIRE

Moreno, Luis Ferney

2016-01-01

Since the 1990s, several countries in Latin America liberalized and privatized the public utilities business. As a consequence, there was a transit from the Entrepreneur State to the Regulatory State, the latter being traditionally understood as a model of regulation for competition, with a mayor concern only on economic objectives. Notwithstanding, the socioeconomic reality of Latin American countries, in particular Colombia, presented the fact that competition cannot be the only priority, a...

ASPECTS CONCERNING INTERIM FINANCIAL REPORTING IN ROMANIA: STANDARDS AND REGULATIONS

Directory of Open Access Journals (Sweden)

Aristita Rotila

2014-12-01

Full Text Available The mechanisms employed for the communication of accounting information that is necessary for users in their economic decision-making process consist of the financial statements of an entity. All legal entities, no matter the domain of their activity, have the obligation to draw up annual financial statements for every completed financial year. For certain categories of entities, reporting obligations are also required for periods other than the annual reporting, throughout the financial year. It is the case of interim financial reporting. At the level of the international accounting framework, the aspects related to interim financial reporting are the subject of a separate standard, namely, IAS 34 Interim Financial Reporting. In Romania, the current system of accounting regulations concerning the annual financial statements comprises accounting regulations that comply with the European directives and which apply to the various categories of entities, on the one hand and, on the other, accounting regulations in line with the IFRS, which are applicable to other classes of entities from certain activity sectors. The accounting regulations that apply to each category refer to, among other things, the contents and the format of financial statements that have to be presented. Analysing the system of norms and regulations, this article identifies the requirements concerning interim financial reporting in Romania, with reference to the different types of entities.

Comparative study of conditions and instruments of economic regulation of networked public services

International Nuclear Information System (INIS)

Henry, Claude; Curien, Nicolas; Gassner, Katharina; Krom, Hans de

1999-11-01

In order to provide a comparative view on implemented regulations regarding networked public services like electric power distribution, train transport, telecommunications, or mail services, this collective publication gathers six studies which respectively address the cases of Germany, Spain, Italy, the Netherlands, the United Kingdom, and Sweden. For each of them, the authors report, analyse and discuss the evolution and implementation of regulation or deregulation processes, the content of the relevant laws which can be specific to a sector, the role and the importance of public and private actors, and the market status and operation

Anomalies in the Fujikawa method using parameter-dependent regulators

International Nuclear Information System (INIS)

Urrutia, L.F.; Vergara, J.D.

1992-01-01

We propose an extended definition of the regularized Jacobian which allows the calculation of anomalies using parameter-dependent regulators in the Fujikawa approach. This extension incorporates the basic Green's function of the problem in the regularized Jacobian, allowing us to interpret a specific regularization procedure as a way of selecting the finite part of the Green's function, in complete analogy with what is done at the level of the effective action. In this way we are able to consider the effect of counterterms in the regularized Jacobian in order to relate different regularization procedures. We also discuss the ambiguities that arise in our prescription due to some freedom in the place where we can insert the regulator, using charge-conjugation invariance as a guiding principle. The method is applied to the case of vector and axial-vector anomalies in two- and four-dimensional quantum electrodynamics. In the first situation we recover the standard family of anomalies calculated by the point-splitting regularization prescription. We also study in detail an alternative choice in the position of the regulator and we calculate explicitly all the currents that generate the families of anomalies that we are considering. Next we extend the calculation to four dimensions, using the same prescriptions as before, and we compare the results with those obtained from the point-splitting calculation, which we also perform in the case of the vector anomaly. A discussion of the relation among the results obtained by different regularization prescriptions is given in terms of the allowed counterterms in the regularized Jacobian, which are highly constrained by the requirement of charge-conjugation invariance

Private regulation in EU better regulation : Past performance and future promises

NARCIS (Netherlands)

Verbruggen, Paul

The promotion of private regulation is frequently part of better regulation programmes. Also the Better Regulation programme of the European Union (EU) initiated in 2002 advocated forms of private regulation as important means to improve EU law-making activities. However, for various reasons the

Fostering Self-Regulated Learning through Distance Education: A Case Study of M.Phil Secondary Teacher Education Program of Allama Iqbal Open University

Science.gov (United States)

Ambreen, Munazza; Haqdad, Ambreen; Saleem, Wajid A.

2016-01-01

Self-regulated learning (SLR) has been recognized as a pivotal antecedent of students' effective learning and academic achievement. A self-regulated learner can independently and effectively plan for learning, choose and use appropriate learning strategies and reflect and monitor learning progress. Self-regulated learning, for learners in general…

Assessing the economic potential of electric vehicles to provide ancillary services. The case of Germany

Energy Technology Data Exchange (ETDEWEB)

Schuller, Alexander; Rieger, Fabian [Karlsruhe Institute of Technology, Karlsruhe (Germany)

2013-09-15

The Vehicle-to-Grid (V2G) concept is a promising possibility for the integration of electric vehicles (EVs) into the power grid. This article presents an economic evaluation of EVs participating in the ancillary service market (primary, secondary and tertiary regulation) for the case of Germany, based on a price data set from 2011 and 2012. We examine the economic potential of nine general options to participate in the regulation market based on real-life EV specifications, connection powers and regulation energy prices. Results show that in the most profitable case a maximum average yearly profit of 730.31 Euro per vehicle is possible for negative regulation with payment direction TSO to provider in the secondary regulation market. Furthermore a sensitivity analysis is performed for all of the analyzed participation scenarios in order to identify crucial parameters for a possible V2G implementation. Major parameters for the successful implementation of V2G are the provided power per vehicle, the time an EV is available to the grid and the variable energy storage costs it incurs.

Frontiers of environmental regulation: environmental management systems: a regulator`s perspective

Energy Technology Data Exchange (ETDEWEB)

Stone, M.J. [South Australian Dept. of Mines and Energy, Adelaide, SA (Australia)

1996-12-31

Leading edge companies throughout the world have embraced management systems to achieve optimal sustainable performance in the ever changing business environment of the 1990s. Given that the natural environment and environmental performance have become major issues affecting organizations, the need for integrating environmental management with all the other components of an organization`s overall management approach is now widely recognized. This paper is organized in five parts. The first explores recently released environmental standards, the interim environmental management systems (EMS) general guidelines standard AS/NZS ISO 14004 (Int) and identifies how this has dealt with the regulator/community/company interface. The second identifies company requirements for addressing environmental issues. The third, considers regulatory theory to identify current requirements for an effective regulatory system and how this can interface with a company`s EMS. These form the basis in the fourth section for identifying some opportunities which occur at the company/ regulator interface. The fifth and final section draws a number of conclusions about the current frontiers of environmental regulation. The coincidence of the requirements of a regulatory framework with the areas of interface between what is referred to in the draft International Standard for EMS as `Interested Parties`, the regulators and community, are identified. (author). 1 tab., 2 figs., 20 refs.

Re-Engineering Biosafety Regulations In India: Towards a Critique of Policy, Law and Prescriptions

Directory of Open Access Journals (Sweden)

A. Damodaran

2005-06-01

Full Text Available This article surveys the structure and essence of India’s biosafety regulations from an evolutionary perspective. After detailing the processes associated with the biosafety law and guidelines in the country, this article looks critically at recent efforts to re-engineer the regulations. It is argued that India’s biosafety regulations should move towards a more inclusive approach, which will facilitate transparent and informed decision-making, based on stakeholder-convergence. It is also suggested that the entire spectrum of laws and regulations that have a direct or indirect bearing on biosafety in India, need to be explored so that greater coherence could be secured in the management of biotechnology products that are sensitive to the environment. Drawing from the experience of the Bt cotton case, the article advocates a greater role for civil society and grassroots organizations.

'Reasonable' regulation of low doses in the Netherlands?

International Nuclear Information System (INIS)

Zuur, Ciska

2002-01-01

As long as it is not clear exactly what the risks of low doses are, exposures should be regulated to be 'as low as reasonably achievable' (ALARA). In radiation protection, for normal situations, this means that a projected dose reduction can only be obligatory when the efforts needed to achieve the reduction are 'reasonable' in comparison with it, economical and social aspects being taken into account. In the recent Dutch regulations, 'reasonable' values have been established for the relevant parameters used in the ALARA concept and the paper discusses the values required to calculate the doses for the critical group due to a source. In some cases, the effort expended in making the ALARA dose assessments might not be reasonable in comparison with the dose reduction to be expected. The system which has been developed in the Netherlands to avoid these 'unreasonable' dose calculations, measurements and assessments is explained. (author)

2012 Annual Report of Chapter VI of the Staff Rules and Regulations (Settlement of disputes and discipline) - HR Department

CERN Document Server

Schepens, A; CERN. Geneva. HR Department

1013-01-01

The 2012 Annual Report under Chapter VI (“Settlement of Disputes and Discipline”) of the Staff Rules and Regulations (SRR) serves to report cases of submission of requests for review, internal appeals, appeals to the ILOAT, and cases in which disciplinary action was taken.

2011 Annual Report of Chapter VI of the Staff Rules and Regulations (Settlement of disputes and discipline) - HR Department

CERN Document Server

Schepens, A; CERN. Geneva. HR Department

2012-01-01

The 2011 Annual Report under Chapter VI (“Settlement of Disputes and Discipline”) of the Staff Rules and Regulations (SRR) serves to report cases of submission of requests for review, internal appeals, appeals to the ILOAT, and cases in which disciplinary action was taken.

Peak regulation right

International Nuclear Information System (INIS)

Gao, Z. |; Ren, Z.; Li, Z.; Zhu, R.

2005-01-01

A peak regulation right concept and corresponding transaction mechanism for an electricity market was presented. The market was based on a power pool and independent system operator (ISO) model. Peak regulation right (PRR) was defined as a downward regulation capacity purchase option which allowed PRR owners to buy certain quantities of peak regulation capacity (PRC) at a specific price during a specified period from suppliers. The PRR owner also had the right to decide whether or not they would buy PRC from suppliers. It was the power pool's responsibility to provide competitive and fair peak regulation trading markets to participants. The introduction of PRR allowed for unit capacity regulation. The PRR and PRC were rated by the supplier, and transactions proceeded through a bidding process. PRR suppliers obtained profits by selling PRR and PRC, and obtained downward regulation fees regardless of whether purchases are made. It was concluded that the peak regulation mechanism reduced the total cost of the generating system and increased the social surplus. 6 refs., 1 tab., 3 figs

Regulation for the accomplishment of public purposes: the case of public utilities in Colombia

OpenAIRE

Moreno, Luis Ferney

2016-01-01

Since the 1990s, several countries in Latin America liberalized and privatized the public utilities business. As a consequence, there was a transit from the Entrepreneur State to the Regulatory State, the latter being traditionally understood as a model of regulation for competition, with a mayor concern only on economic objectives. Notwithstanding, the socioeconomic reality of Latin American countries, in particular Colombia, presented the fact that competition cannot be the only priority, a...

Regulating through leverage: Civil regulation in China

NARCIS (Netherlands)

Fürst, K.

2016-01-01

The overarching goal of this study is to examine the efforts of Chinese NGOs to prevent and/or control industrial pollution risks and then use the findings of this research to study the nature of civil regulation in, and beyond, China’s authoritarian setting. It first argues that 'regulation through

Should the model for risk-informed regulation be game theory rather than decision theory?

Science.gov (United States)

Bier, Vicki M; Lin, Shi-Woei

2013-02-01

Risk analysts frequently view the regulation of risks as being largely a matter of decision theory. According to this view, risk analysis methods provide information on the likelihood and severity of various possible outcomes; this information should then be assessed using a decision-theoretic approach (such as cost/benefit analysis) to determine whether the risks are acceptable, and whether additional regulation is warranted. However, this view ignores the fact that in many industries (particularly industries that are technologically sophisticated and employ specialized risk and safety experts), risk analyses may be done by regulated firms, not by the regulator. Moreover, those firms may have more knowledge about the levels of safety at their own facilities than the regulator does. This creates a situation in which the regulated firm has both the opportunity-and often also the motive-to provide inaccurate (in particular, favorably biased) risk information to the regulator, and hence the regulator has reason to doubt the accuracy of the risk information provided by regulated parties. Researchers have argued that decision theory is capable of dealing with many such strategic interactions as well as game theory can. This is especially true in two-player, two-stage games in which the follower has a unique best strategy in response to the leader's strategy, as appears to be the case in the situation analyzed in this article. However, even in such cases, we agree with Cox that game-theoretic methods and concepts can still be useful. In particular, the tools of mechanism design, and especially the revelation principle, can simplify the analysis of such games because the revelation principle provides rigorous assurance that it is sufficient to analyze only games in which licensees truthfully report their risk levels, making the problem more manageable. Without that, it would generally be necessary to consider much more complicated forms of strategic behavior (including

77 FR 14490 - Defense Federal Acquisition Regulation Supplement: Alleged Crimes By or Against Contractor...

Science.gov (United States)

2012-03-12

... Federal Acquisition Regulation Supplement: Alleged Crimes By or Against Contractor Personnel (DFARS Case... (DFARS) to expand coverage on contractor requirements and responsibilities relating to alleged crimes by or against contractor personnel. DATES: Comment Date: Comments on the proposed rule should be...

New requirements, rules and regulations, and vested rights of nuclear power plants

International Nuclear Information System (INIS)

Raetzke, C.

2006-01-01

The article deals with the question whether new requirements can be imposed on existing nuclear power plants. It was promoted by the fact that the German Federal Ministry for the Environment currently is working on a thorough revision of German nuclear regulations. When looking at backfitting requirements, the all-important question is whether new findings show that the provisions taken in the license to guarantee the 'necessary precautions' (as defined in the German Atomic Energy Act) contain errors or omissions; only in this case can the authority demand that remedial measures, including backfitting, be taken. Beyond that, German nuclear law contains no obligation for operators to improve and develop safety still further. This applies regardless of whether new requirements are justified by new technical possibilities or new scientific analyses or whether they are prompted by a mere abstract re-evaluation of the safety level to be achieved. In the former case, if there are good technical or scientific reasons, the operators, as a rule, will perform backfitting voluntarily. Pursuant to these criteria, the article covers three categories of backfitting requirements and illustrates them by examples. These general principles are also valid when a new set of regulations - as planned by the BMU - are put into effect and applied. They may lead to existing plants not having to comply fully with the requirements contained in new regulations. (orig.)

Output regulation of large-scale hydraulic networks with minimal steady state power consumption

NARCIS (Netherlands)

Jensen, Tom Nørgaard; Wisniewski, Rafał; De Persis, Claudio; Kallesøe, Carsten Skovmose

2014-01-01

An industrial case study involving a large-scale hydraulic network is examined. The hydraulic network underlies a district heating system, with an arbitrary number of end-users. The problem of output regulation is addressed along with a optimization criterion for the control. The fact that the

75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

Science.gov (United States)

2010-12-09

..., and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition... for Business Systems--Definition and Administration (DFARS Case 2009-D038) in the Federal Register on... improve the effectiveness of DoD oversight of contractor business systems. The comment period is being...

76 FR 58122 - Defense Federal Acquisition Regulation Supplement; Material Inspection and Receiving Report...

Science.gov (United States)

2011-09-20

... acceptance point and replacing it with more specific data entries for inspection, acceptance, and ship to Do..., acceptance, and ship-to fields but kept the source, destination, and other inspection and acceptance points... Acquisition Regulation Supplement; Material Inspection and Receiving Report (DFARS Case 2009-D023) AGENCY...

77 FR 30368 - Defense Federal Acquisition Regulation Supplement; Utilization of Domestic Photovoltaic Devices...

Science.gov (United States)

2012-05-22

... arrangement, the Government would take title to the devices during contract performance or at the conclusion... rule will promote utilization of domestic photovoltaic devices, even when the Government does not take... Devices (DFARS Case 2011-D046) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD...

Misleading advertising for antidepressants in Sweden: a failure of pharmaceutical industry self-regulation.

Science.gov (United States)

Zetterqvist, Anna V; Mulinari, Shai

2013-01-01

The alleged efficacy of pharmaceutical industry self-regulation has been used to repudiate increased government oversight over promotional activity. European politicians and industry have cited Sweden as an excellent example of self-regulation based on an ethical code. This paper considers antidepressant advertising in Sweden to uncover the strengths and weaknesses of self-regulation. We analyzed all antidepressant advertisements in the Swedish Medical Journal, 1994-2003. The regulation of these advertisements was analyzed using case reports from self-regulatory bodies. The authors independently reviewed this material to investigate: (1) extent of violative advertising; (2) pattern of code breaches; (3) rate at which the system reacted to violative advertising; (4) prevalence of and oversight over claims regarding antidepressant efficacy and disease causality, and (5) costs for manufactures associated with violative advertising. Self-regulatory bodies identified numerous code breaches. Nonetheless, they failed to protect doctors from unreliable information on antidepressants, since as many as 247 of 722 (34%) advertisements breached the industry code. Self-regulatory bodies repeatedly failed to challenge inflated claims of antidepressant efficacy, lending evidence of lax oversight. On average, 15 weeks elapsed between printing and censure of a wrongful claim, and in 25% of cases 47 weeks or more elapsed. Industry paid roughly €108000 in fines for violative advertising, adding an estimated additional average cost of 11% to each purchased violative advertisement, or amounting to as little as 0.009% of total antidepressant sales of around €1.2 billion. Lax oversight, combined with lags in the system and low fines for violations, may explain the Swedish system's failure to pressure companies into providing reliable antidepressants information. If these shortcomings prove to be consistent across self-regulatory settings, and if appropriate measures are not taken to

Poisoned Wine: Regulation, Chemical Analyses, and Spanish-French Trade in the 1930s.

Science.gov (United States)

Suay-Matallana, Ignacio; Guillem-Llobat, Ximo

2018-04-16

This paper describes the resources, scientific spaces, and experts involved in the study of a mass poisoning caused by the drinking of arsenic-contaminated wine exported from Spain to France in 1932. Local and international periodicals record the poisoning of 300 French sailors, and stressed the commercial implications of the case. We discuss the reports prepared by different experts (mainly physicians, agricultural engineers, and customs chemists). Their work was not limited to preparing technical publications or chemical analyses; they also actively defended the quality of their local wine, and played a major role in the discussions regarding the regulation of the international wine market in the 1930s, when new standards regarding the analysis of wine were being considered. Curiously, this well-publicised case of mass poisoning did not have any noticeable consequences in the international regulation of wine. This absence of subsequent regulatory action and the role of experts are central topics of the paper.

ALDI South – A Case of Tight Employee Control?

DEFF Research Database (Denmark)

Winkler, Ingo

2014-01-01

Despite its economic success, ALDI has always been criticised for how the company treats its employees. In 2012, critisim reached a new peak in Germany, triggered by a book of a former ALDI manager. His detailed description of the working conditions in ALDI South sparked a widespread interest...... in the media. Drawing on the book and other published sources, this case incident details some of the working conditions and management practices at ALDI. The text sheds particular light on practices and techniques to regulate ALDI employees, both in the shops and middle management. On the one hand, it paints...... a picture of ALDI’s determined strive towards keeping costs low and employee performance high, hence, being able to offer low-priced and quality products to its customers. On the other hand, however, the various examples from this case illuminate how ALDI regulates employee behaviour. Some may argue...

Teacher-Evaluated Self-Regulation Is Related to School Achievement and Influenced by Parental Education in Schoolchildren Aged 8-12: A Case-Control Study.

Science.gov (United States)

van Tetering, Marleen A J; de Groot, Renate H M; Jolles, Jelle

2018-01-01

There are major inter-individual differences in the school achievements of students aged 8-12. The determinants of these differences are not known. This paper investigates two possible factors: the self-regulation of the student and the educational levels obtained by their parents. The study first investigates whether children with high and low academic achievement differ in their self-regulation. It then evaluates whether there are differences in the self-regulation of children with high and moderate-to-low level of parental education (LPE). The focus was on the self-regulation of students as judged by their teacher. Teacher evaluations were assessed using an observer questionnaire: the Amsterdam Executive Functioning Inventory. Results showed that students with low school achievement had substantially lower teacher-perceived self-regulation than children with high school achievement. Furthermore, teacher-perceived self-regulation was lower for children with moderate-to-low LPE than for children with high LPE. The findings suggest that interventions on the domain of self-regulation skills should be developed and used, particularly in students at risk of poor school achievement.

Radiation regulation

International Nuclear Information System (INIS)

Braithwaite, J.; Grabosky, P.

1985-01-01

The five main areas of radiation regulation considered are radiation exposure in the mining of uranium and other minerals, exposure in the use of uranium in nuclear reactors, risks in the transport of radioactive materials and hazards associated with the disposal of used materials. In Australia these problems are regulated by mines departments, the Australian Atomic Energy Commission and radiation control branches in state health departments. Each of these instutional areas of regulation is examined

BLACK HOLE-GALAXY CORRELATIONS WITHOUT SELF-REGULATION

International Nuclear Information System (INIS)

Anglés-Alcázar, Daniel; Özel, Feryal; Davé, Romeel

2013-01-01

Recent models of black hole growth in a cosmological context have forwarded a paradigm in which the growth is self-regulated by feedback from the black hole itself. Here we use cosmological zoom simulations of galaxy formation down to z = 2 to show that such strong self-regulation is required in the popular spherical Bondi accretion model, but that a plausible alternative model in which black hole growth is limited by galaxy-scale torques does not require self-regulation. Instead, this torque-limited accretion model yields black holes and galaxies evolving on average along the observed scaling relations by relying only on a fixed, 5% mass retention rate onto the black hole from the radius at which the accretion flow is fed. Feedback from the black hole may (and likely does) occur, but does not need to couple to galaxy-scale gas in order to regulate black hole growth. We show that this result is insensitive to variations in the initial black hole mass, stellar feedback, or other implementation details. The torque-limited model allows for high accretion rates at very early epochs (unlike the Bondi case), which if viable can help explain the rapid early growth of black holes, while by z ∼ 2 it yields Eddington factors of ∼1%-10%. This model also yields a less direct correspondence between major merger events and rapid phases of black hole growth. Instead, growth is more closely tied to cosmological disk feeding, which may help explain observational studies showing that, at least at z ∼> 1, active galaxies do not preferentially show merger signatures.

Intergenerational Transmission of Self-Regulation: A Multidisciplinary Review and Integrative Conceptual Framework

Science.gov (United States)

Bridgett, David J.; Burt, Nicole M.; Edwards, Erin S.; Deater-Deckard, Kirby

2014-01-01

This review examines mechanisms contributing to the intergenerational transmission of self-regulation. To provide an integrated account of how self-regulation is transmitted across generations, we draw from over 75 years of accumulated evidence, spanning case studies to experimental approaches, in literatures covering developmental, social, and clinical psychology, and criminology, physiology, genetics, and human and animal neuroscience (among others). First, we present a taxonomy of what self-regulation is and then examine how it develops – overviews that guide the main foci of the review. Next, studies supporting an association between parent and child self-regulation are reviewed. Subsequently, literature that considers potential social mechanisms of transmission, specifically parenting behavior, inter-parental (i.e., marital) relationship behaviors, and broader rearing influences (e.g., household chaos) are considered. Finally, literature providing evidence that prenatal programming may be the starting point of the intergenerational transmission of self-regulation is covered, along with key findings from the behavioral and molecular genetics literatures. To integrate these literatures, we introduce the Self-Regulation Intergenerational Transmission Model, a framework that brings together prenatal, social, and neurobiological mechanisms (spanning endocrine, neural, and genetic levels, including gene-environment interplay and epigenetic processes) to explain the intergenerational transmission of self-regulation. This model also incorporates potential transactional processes between generations (e.g., children’s self-regulation and parent-child interaction dynamics that may affect parents’ self-regulation) that further influence intergenerational processes. In pointing the way forward, we note key future directions and ways to address limitations in existing work throughout the review and in closing. We also conclude by noting several implications for

Aspects on Media Self Regulation Reflected in the Activity of Romanian Journalists

Directory of Open Access Journals (Sweden)

Daniela Aurelia Popa

2011-05-01

Full Text Available The media organizations in Romania, reticent to the idea to constraint the press freedom, manage to understand the importance of implementing a system of media responsibility. Therefore, the present study is a research in incipient stage that begins with the identification of the initiatives of media self regulation as an alternative to the efforts of enacting press in Romania. The identification of the self regulating system in Romania will be accomplished through the description of the context of development of the media responsibility system in the Romanian journalistic culture and by underlining the self regulation initiatives. For the delineation and establishment of such important self regulation initiatives, the activity of an ethical instance is necessary, for the defense and solving cases of norms contained by the new deontological code. The establishment of such an instance in Romania will represent a viable solution for the development of a more ethical professional environment that confirms the assumption of media responsibility for the adhesion to quality journalistic standards.

Case Study: Using Microbe Molecular Biology for Gulf Oil Spill Clean Up

Science.gov (United States)

Jones, Daniel R.

2011-01-01

This case has the student actively investigate the regulation of expression of a novel bacterial gene in the context of attempts to solve a real world problem, clean up of the April 2010 Deep Water Horizon oil spill in the Gulf of Mexico. Although the case is fictitious, it is based on factual gene regulatory characteristics of oil-degrading…

Reducing Conservatism in Aircraft Engine Response Using Conditionally Active Min-Max Limit Regulators

Science.gov (United States)

May, Ryan D.; Garg, Sanjay

2012-01-01

Current aircraft engine control logic uses a Min-Max control selection structure to prevent the engine from exceeding any safety or operational limits during transients due to throttle commands. This structure is inherently conservative and produces transient responses that are slower than necessary. In order to utilize the existing safety margins more effectively, a modification to this architecture is proposed, referred to as a Conditionally Active (CA) limit regulator. This concept uses the existing Min-Max architecture with the modification that limit regulators are active only when the operating point is close to a particular limit. This paper explores the use of CA limit regulators using a publicly available commercial aircraft engine simulation. The improvement in thrust response while maintaining all necessary safety limits is demonstrated in a number of cases.

Approaches to link RNA secondary structures with splicing regulation

DEFF Research Database (Denmark)

Plass, Mireya; Eyras, Eduardo

2014-01-01

In higher eukaryotes, alternative splicing is usually regulated by protein factors, which bind to the pre-mRNA and affect the recognition of splicing signals. There is recent evidence that the secondary structure of the pre-mRNA may also play an important role in this process, either by facilitat...... describes the steps in the analysis of the secondary structure of the pre-mRNA and its possible relation to splicing. As a working example, we use the case of yeast and the problem of the recognition of the 3' splice site (3'ss).......In higher eukaryotes, alternative splicing is usually regulated by protein factors, which bind to the pre-mRNA and affect the recognition of splicing signals. There is recent evidence that the secondary structure of the pre-mRNA may also play an important role in this process, either...

75 FR 75904 - Global Terrorism Sanctions Regulations; Terrorism Sanctions Regulations; Foreign Terrorist...

Science.gov (United States)

2010-12-07

... Terrorism Sanctions Regulations; Terrorism Sanctions Regulations; Foreign Terrorist Organizations Sanctions... Foreign Assets Control (``OFAC'') of the U.S. Department of the Treasury is amending the Global Terrorism Sanctions Regulations (``GTSR'') and the Terrorism Sanctions Regulations (``TSR'') to expand the scope of...

Consumer engagement in alternative energy-Can the regulators and suppliers be trusted?

International Nuclear Information System (INIS)

Mumford, John; Gray, David

2010-01-01

The introduction of alternative energy requires collaboration between consumers, energy suppliers and regulators. A fundamental question is, will consumers engage with this agenda and, in particular, will they trust the institutions sufficiently to enable the collaborations that are needed. Present indications suggest that consumers have little trust in the established institutions and tend to reject such collaborations. This article presents two case studies which explore the way consumers, regulators and energy suppliers interact in relation to alternative energy projects. It analyses the inter-group interactions from the perspective of symbolic interactionism and discusses the aspects that undermine trust, leading to suggestions for improved trust.

Consumer engagement in alternative energy. Can the regulators and suppliers be trusted?

Energy Technology Data Exchange (ETDEWEB)

Mumford, John [Senior Visiting Fellow, School of Management, University of Surrey (United Kingdom); Gray, David [Professor of Management Learning, School of Management, University of Surrey, GU2 7XH (United Kingdom)

2010-06-15

The introduction of alternative energy requires collaboration between consumers, energy suppliers and regulators. A fundamental question is, will consumers engage with this agenda and, in particular, will they trust the institutions sufficiently to enable the collaborations that are needed. Present indications suggest that consumers have little trust in the established institutions and tend to reject such collaborations. This article presents two case studies which explore the way consumers, regulators and energy suppliers interact in relation to alternative energy projects. It analyses the inter-group interactions from the perspective of symbolic interactionism and discusses the aspects that undermine trust, leading to suggestions for improved trust. (author)

Consumer engagement in alternative energy-Can the regulators and suppliers be trusted?

Energy Technology Data Exchange (ETDEWEB)

Mumford, John, E-mail: John.Mumford@uk.bp.co [School of Management, University of Surrey (United Kingdom); Gray, David [School of Management, University of Surrey, GU2 7XH (United Kingdom)

2010-06-15

The introduction of alternative energy requires collaboration between consumers, energy suppliers and regulators. A fundamental question is, will consumers engage with this agenda and, in particular, will they trust the institutions sufficiently to enable the collaborations that are needed. Present indications suggest that consumers have little trust in the established institutions and tend to reject such collaborations. This article presents two case studies which explore the way consumers, regulators and energy suppliers interact in relation to alternative energy projects. It analyses the inter-group interactions from the perspective of symbolic interactionism and discusses the aspects that undermine trust, leading to suggestions for improved trust.

75 FR 34283 - Federal Acquisition Regulation; FAR Case 2009-025, Disclosure and Consistency of Cost Accounting...

Science.gov (United States)

2010-06-16

... Regulation (FAR) to align the FAR with the revised Cost Accounting Standards (CAS) Board clause, Disclosure....230-4 is replaced in its entirety and re-titled ``Disclosure and Consistency of Cost Accounting...) Disclosure and Consistency of Cost Accounting Practices-- Foreign Concerns. (1) The contracting officer shall...

Enforcement actions and their effectiveness in securities regulation: Empirical evidence from management earnings forecasts

Directory of Open Access Journals (Sweden)

Yunling Song

2012-03-01

Full Text Available Due to resource constraints, securities regulators cannot find or punish all firms that have conducted irregular or even illegal activities (hereafter referred to as fraud. Those who study securities regulations can only find the instances of fraud that have been punished, not those that have not been punished, and it is these unknown cases that would make the best control sample for studies of enforcement action criteria. China’s mandatory management earnings forecasts solve this sampling problem. In the A-share market, firms that have not forecasted as mandated are likely in a position to be punished by securities regulators or are attempting to escape punishment, and their identification allows researchers to build suitable study and control samples when examining securities regulations. Our results indicate that enforcement actions taken by securities regulators are selective. The probability that a firm will be punished for irregular management forecasting is significantly related to proxies for survival rates. Specifically, fraudulent firms with lower return on assets (ROAs or higher cash flow risk are more likely to be punished. Further analysis shows that selective enforcement of regulations has had little positive effect on the quality of listed firms’ management forecasts.

Accounting window dressing and template regulation: A case study of the Australian credit union industry

OpenAIRE

Hillier, D.; Hodgson, A.; Stevenson-Clarke, P.; Lhaopadchan, S.

2008-01-01

This article documents the response of cooperative institutions that were required to adhere to new capital adequacy regulations traditionally geared for profit-maximising organisations. Using data from the Australian credit union industry, we demonstrate that the cooperative philosophy and internal corporate governance structure of cooperatives will lead management to increase capital adequacy ratios through the application of accounting window dressing techniques. This is opposite to the in...

Experience with the 1985 UK ionizing radiation regulations: the regulators' viewpoint

International Nuclear Information System (INIS)

Bines, W.P.; Beaver, P.F.

1991-01-01

The Ionising Radiations Regulations 1985 achieved UK implementation of the Euratom Basic Safety Standards Directive; interim action has taken account of recent revisions of risk estimates and the regulations will not be revised in advance of renegotiation of the Euratom Directive. Wide ranging consultation, central to the development of health and safety legislation in the UK, leads to greater co-operation between regulators and regulated and more acceptable legislation. Examples of co-operation, also of methods of enforcement and the use made of them, are given. The authors conclude that the regulations have stood the test of experience well. (Author)

Meeting licensing restrictions from a regulator's perspective

International Nuclear Information System (INIS)

Autry, V.R.; Ragan, F.A.

1990-01-01

The State of South Carolina was delegated the authority by the US Nuclear Regulatory Commission to regulate the receipt, possession, use and disposal of radioactive material as an Agreement State. Since 1970, the state has been the principal regulatory authority for the Barnwell Low-Level Waste Disposal Facility operated by Chem-Nuclear Systems, Inc. The radioactive material license issued authorizing the receipt and disposal of low level waste has experienced many changes necessitated by technical advancements which led to stricter controls and restrictions for shallow land disposal. Low level waste has evolved from simple contaminated items with minimal radioactivity, to complex waste streams requiring elaborate processing and containment of high quantities of radionuclides. Waste streams also require extensive analysis and qualification to meet many of the restrictions imposed at the burial facility and comply with national standards and regulations for classification. This paper presents a chronological history of many of these restrictions, the rationale for them, and the waste generators' abilities and inabilities to comply. In addition, case histories of some examples are discussed

Utility regulation and the legislative process in Oregon: a case study

Energy Technology Data Exchange (ETDEWEB)

None

1979-01-01

This case study discusses the strategies employed by the Public Utility Commissioner and the Oregon Department of Energy in the design, passage and implementation of a set of energy conservation bills. Information is included on the development of new legislation for energy conservation and management, on developing public acceptance of such legislation, and the cooperation received from utility companies to affect implementation. The lessons in strategy and tactics and the skillful use of the legislative process to get the package of bills enacted should have immediate value for those about to undertake a similar effort in their state. (LCL)

Correlation set analysis: detecting active regulators in disease populations using prior causal knowledge

Directory of Open Access Journals (Sweden)

Huang Chia-Ling

2012-03-01

Full Text Available Abstract Background Identification of active causal regulators is a crucial problem in understanding mechanism of diseases or finding drug targets. Methods that infer causal regulators directly from primary data have been proposed and successfully validated in some cases. These methods necessarily require very large sample sizes or a mix of different data types. Recent studies have shown that prior biological knowledge can successfully boost a method's ability to find regulators. Results We present a simple data-driven method, Correlation Set Analysis (CSA, for comprehensively detecting active regulators in disease populations by integrating co-expression analysis and a specific type of literature-derived causal relationships. Instead of investigating the co-expression level between regulators and their regulatees, we focus on coherence of regulatees of a regulator. Using simulated datasets we show that our method performs very well at recovering even weak regulatory relationships with a low false discovery rate. Using three separate real biological datasets we were able to recover well known and as yet undescribed, active regulators for each disease population. The results are represented as a rank-ordered list of regulators, and reveals both single and higher-order regulatory relationships. Conclusions CSA is an intuitive data-driven way of selecting directed perturbation experiments that are relevant to a disease population of interest and represent a starting point for further investigation. Our findings demonstrate that combining co-expression analysis on regulatee sets with a literature-derived network can successfully identify causal regulators and help develop possible hypothesis to explain disease progression.

76 FR 59623 - Defense Federal Acquisition Regulation Supplement; Only One Offer (DFARS Case 2011-D013)

Science.gov (United States)

2011-09-27

..., 215, 216, and 252 RIN 0750-AH11 Defense Federal Acquisition Regulation Supplement; Only One Offer... Supplement (DFARS) to address acquisitions using competitive procedures in which only one offer is received... days, if the solicitation allowed fewer than 30 days for receipt of proposals and only one offer is...

75 FR 18029 - Defense Federal Acquisition Regulation Supplement; Export-Controlled Items (DFARS Case 2004-D010)

Science.gov (United States)

2010-04-08

... regulations and prescribes a contract clause to address those responsibilities. DATES: Effective Date: April 8... activities and communication between the parties to a potential contract, and to have the resulting contract... Government needs to convey to the universities the information that certain work is export-controlled. DoD...

Overcoming Gridlock: The Council Presidency, Legislative Activity and Issue De-Coupling in the Area of Occupational Health and Safety Regulation

Directory of Open Access Journals (Sweden)

Andreas Warntjen

2013-02-01

Full Text Available A member state of the European Union can use its term as the Council president to make progress on pending but stalled proposals which it would like to see adopted. This case study of the directive on the risk arising from physical agents shows how a Council presidency can use issue subtraction, additional meetings and compromise proposals to overcome gridlock in the Council. There is a notable difference in terms of legislative activity between the presidencies of high regulation and low regulation countries. High regulation countries put forward compromise proposals and scheduled additional meetings to resolve outstanding issues. The case study also demonstrates the importance of issue subtraction. The original proposal was gridlocked in the Council for five years. Only after the original proposal was split up into several dossiers (issue de-coupling was it possible to reach agreement.

Toward a physical basis of attention and self-regulation

Science.gov (United States)

Posner, Michael I.; Rothbart, Mary K.

2009-06-01

disorders involving deletion of this gene exhibit large deficits in self-regulation. Alleles of other genes influencing dopamine and serotonin transmission have also been found to influence ability to resolve conflict in cognitive tasks. However, as is the case for many genes, the effectiveness of COMT alleles in shaping self-regulation depends upon cultural influences such as parenting. Studies find that aspects of parenting quality and parent training can influence child behavior and the efficiency of self-regulation. During development, the network that relates to self-regulation undergoes important changes in connectivity. Infants can use parts of the self-regulatory network to detect errors in sensory information, but the network does not yet have sufficient connectivity to organize brain activity in a coherent way. During middle childhood, along with increased projection cells involved in remote connections of dorsal anterior cingulate and prefrontal and parietal cortex, executive network connectivity increases and shifts from predominantly short to longer range connections. During this period specific exercises can influence network development and improve self-regulation. Understanding the physical basis of self-regulation has already cast light on individual differences in normal and pathological states and gives promise of allowing the design of methods to improve aspects of human development.

76 FR 38053 - Defense Federal Acquisition Regulation Supplement; Successor Entities to the Netherlands Antilles...

Science.gov (United States)

2011-06-29

... Federal Acquisition Regulation Supplement; Successor Entities to the Netherlands Antilles (DFARS Case 2011... ``designated country'' due to the change in the political status of the islands that comprised the Netherlands..., 2010, Curacao and Sint Maarten became autonomous territories of the Kingdom of the Netherlands. Bonaire...

Toward the Framework and Implementation for Clearance of Materials from Regulated Facilities

International Nuclear Information System (INIS)

Chen, Shih-Yew; Moeller, Dade W.; Dornsife, William P.; Meyer, H Robert; Lamastra, Anthony; Lubenau, Joel O.; Strom, Daniel J.; Yusko, James G.

2005-01-01

The disposition of solid materials from nuclear facilities has been a subject of public debate for several decades. The primary concern has been the potential health effects resulting from exposure to residual radioactive materials to be released for unrestricted use. These debates have intensified in the last decade as many regulated facilities are seeking viable management decisions on the disposition of the large amounts of materials potentially containing very low levels of residual radioactivity. Such facilities include the nuclear weapons complex sites managed by the U.S. Department of Energy (DOE), commercial power plants licensed by the U.S. Nuclear Regulatory Commission (NRC), and other materials licensees regulated by the NRC or the Agreement States. Other facilities that generate radioactive material containing naturally occurring radioactive materials (NORM) or technologically enhanced NORM (TENORM) are also seeking to dispose of similar materials that may be radioactively contaminated. In contrast to the facilities operated by the DOE and the nuclear power plants licensed by the NRC, NORM and TENORM facilities are regulated by the individual states. Current federal laws and regulations do not specify criteria for releasing these materials that may contain residual radioactivity of either man-made or natural origin from regulatory controls. In fact, the current regulatory scheme offers no explicit provision as to permit materials being released as ''non-radioactive'', including those that are essentially free of contamination. The only method used to date with limited success has been case-by-case evaluation and approval. In addition, there is a poorly defined and inconsistent regulatory framework for regulating NORM and TENORM. Some years ago, the International Atomic Energy Agency (IAEA) introduced the concept of clearance, that is, controlling releases of any such materials within the regulatory domain. This paper aims to clarify clearance as an

Toward the framework and implementation for clearance of materials from regulated facilities.

Science.gov (United States)

Chen, S Y; Moeller, D W; Dornsife, W P; Meyer, H R; Lamastra, A; Lubenau, J O; Strom, D J; Yusko, J G

2005-08-01

The disposition of solid materials from nuclear facilities has been a subject of public debate for several decades. The primary concern has been the potential health effects resulting from exposure to residual radioactive materials to be released for unrestricted use. These debates have intensified in the last decade as many regulated facilities are seeking viable management decisions on the disposition of the large amounts of materials potentially containing very low levels of residual radioactivity. Such facilities include the nuclear weapons complex sites managed by the U.S. Department of Energy, commercial power plants licensed by the U.S. Nuclear Regulatory Commission (NRC), and other materials licensees regulated by the NRC or the Agreement States. Other facilities that generate radioactive material containing naturally occurring radioactive materials (NORM) or technologically enhanced NORM (TENORM) are also seeking to dispose of similar materials that may be radioactively contaminated. In contrast to the facilities operated by the DOE and the nuclear power plants licensed by the U.S. Nuclear Regulatory Commission, NORM and TENORM facilities are regulated by the individual states. Current federal laws and regulations do not specify criteria for releasing these materials that may contain residual radioactivity of either man-made or natural origin from regulatory controls. In fact, the current regulatory scheme offers no explicit provision to permit materials being released as "non-radioactive," including those that are essentially free of contamination. The only method used to date with limited success has been case-by-case evaluation and approval. In addition, there is a poorly defined and inconsistent regulatory framework for regulating NORM and TENORM. Some years ago, the International Atomic Energy Agency introduced the concept of clearance, that is, controlling releases of any such materials within the regulatory domain. This paper aims to clarify

2015 Annual Report of Chapter VI of the Staff Rules and Regulations (Settlement of disputes and discipline) - HR Department

CERN Document Server

Lalande, Amanda

2016-01-01

The 2015 Annual Report under Chapter VI (“Settlement of Disputes and Discipline”) of the Staff Rules and Regulations serves to report cases of submission of requests for review; internal appeals; complaints before the Administrative Tribunal of the International Labour Organization (ILOAT); and cases in which disciplinary action was taken.

2016 Annual Report of Chapter VI of the Staff Rules and Regulations (Settlement of disputes and discipline) - HR Department

CERN Document Server

Lalande, Amanda

2017-01-01

The 2016 Annual Report under Chapter VI (“Settlement of Disputes and Discipline”) of the Staff Rules and Regulations serves to report cases of submission of requests for review; internal appeals; complaints before the Administrative Tribunal of the International Labour Organization (ILOAT); and cases in which disciplinary action was taken.

Cysteine regulation of protein function--as exemplified by NMDA-receptor modulation.

Science.gov (United States)

Lipton, Stuart A; Choi, Yun-Beom; Takahashi, Hiroto; Zhang, Dongxian; Li, Weizhong; Godzik, Adam; Bankston, Laurie A

2002-09-01

Until recently cysteine residues, especially those located extracellularly, were thought to be important for metal coordination, catalysis and protein structure by forming disulfide bonds - but they were not thought to regulate protein function. However, this is not the case. Crucial cysteine residues can be involved in modulation of protein activity and signaling events via other reactions of their thiol (sulfhydryl; -SH) groups. These reactions can take several forms, such as redox events (chemical reduction or oxidation), chelation of transition metals (chiefly Zn(2+), Mn(2+) and Cu(2+)) or S-nitrosylation [the catalyzed transfer of a nitric oxide (NO) group to a thiol group]. In several cases, these disparate reactions can compete with one another for the same thiol group on a single cysteine residue, forming a molecular switch composed of a latticework of possible redox, NO or Zn(2+) modifications to control protein function. Thiol-mediated regulation of protein function can also involve reactions of cysteine residues that affect ligand binding allosterically. This article reviews the basis for these molecular cysteine switches, drawing on the NMDA receptor as an exemplary protein, and proposes a molecular model for the action of S-nitrosylation based on recently derived crystal structures.

HOW MATHEMATICS TEACHERS DEVELOP THEIR PUPILS’ SELF-REGULATED LEARNING SKILLS

Directory of Open Access Journals (Sweden)

Iuliana Marchis

2011-11-01

Full Text Available Self-regulated learning skills are important in mathematical problem solving. The aim of the paper is to present a research on how mathematics teachers guide their pupils’ mathematical problem-solving activities in order to increase self-regulation. 62 teachers have filled in a questionnaire developed for this research. The results are show that more than two third of the teachers promote the methods of understanding the problem; develop pupils’ self-efficacy and self-control. But only one third of the teachers ask pupils to use different strategies for solving a problem; ask students to explain the solution to their colleagues. In case of unsuccessful problem solving only one third of the respondents ask pupils to present previous knowledge about the problem or/and recall and try different methods.

Attachment, emotion regulation, and adaptation to breast cancer: assessment of a mediational hypothesis.

Science.gov (United States)

Ávila, Marisa; Brandão, Tânia; Teixeira, Joana; Coimbra, Joaquim Luis; Matos, Paula Mena

2015-11-01

This study examines the links between attachment, adaptation to breast cancer, and the mediating role played by emotional regulation processes. Participants were 127 women with breast cancer recruited in two public hospitals of Porto and at the Portuguese Cancer League. Women completed measures of attachment, quality of life, and emotion regulation. Path models were used to examine the associations between the constructs and to test the mediational hypotheses. Significant associations were found between attachment and adaptation. Dimensions of emotion regulation totally or partially mediated the associations between attachment and adaptation outcomes. Attachment security effects on interpersonal relations were totally mediated by communicating emotions. Also, attachment anxiety effect on physical well-being was totally mediated by rumination. Attachment avoidance effects on psychological outcomes were totally mediated by emotional control and partially mediated by communicating emotions for the case of interpersonal relations. This study highlights the importance of addressing emotional regulation jointly with attachment to deepen the comprehension of the relational processes implicated in adaptation to breast cancer. Results supported a mediational hypothesis, presenting emotional regulation processes as relevant dimensions for the understanding of attachment associations with adaptation to breast cancer. Copyright © 2015 John Wiley & Sons, Ltd.

Demand Constraints and New Demands: Regulations, Markets and Institutions Efficiency (A Case Study for Cape Verde

Directory of Open Access Journals (Sweden)

Bernardo Reynolds Pacheco de Carvalho

2014-08-01

Full Text Available Economic efficiency is a key issue in economic research and for policy design, and certainly for food security challenges. In the food system dynamics the understanding of changes and trends is crucial to improve our capacity to deal with the objectives of sustainable development and quality of life. Food system efficiency evaluation is necessary with regard to production and consumption efficiencies as well as market and governance dilemmas. Regulations and institutional efficiency are crucial aspects that are frequently forgotten, and efforts should be made to improve the capacity to deal with those methodological needs. In many situations, in the real world, data and measurements are difficult or even impossible to get in numeric or quantitative terms. Frequently, a qualitative evaluation is the only way to proceed, but measurements and numeric references are still important, mainly when changes over time are central to the research. The actual paper follows a structural food system model (WFSE – World Food Security Equation and a general equilibrium approach (ICI model – induced changes and innovation model to show in a country case study (Cape Verde the important role of markets and institutions as compared to regulation practices directed to improve economic efficiency subject to demand behavior. Cape Verde is a very challenging country with regard to the food security status (where natural resources are very poor for agricultural production but with great success in global and macro terms in the last 10 years. The main problems nowadays are clearly at local level. The present research tries to highlight the global achievements and explore local assessment efforts on food consumption conditions. A specific region is studied, in the island of Santo Antão, one of the most important production regions. Three different production systems were compared mainly with regard to their respective influence on consumption habits, incomes and

Market, Regulation, Market, Regulation

DEFF Research Database (Denmark)

Frankel, Christian; Galland, Jean-Pierre

2015-01-01

barriers to trade in Europe, realized the free movement of products by organizing progressively several orders of markets and regulation. Based on historical and institutional documents, on technical publications, and on interviews, this article relates how the European Commission and the Member States had......This paper focuses on the European Regulatory system which was settled both for opening the Single Market for products and ensuring the consumers' safety. It claims that the New Approach and Standardization, and the Global Approach to conformity assessment, which suppressed the last technical...... alternatively recourse to markets and to regulations, at the three main levels of the New Approach Directives implementation. The article focuses also more specifically on the Medical Devices sector, not only because this New Approach sector has long been controversial in Europe, and has recently been concerned...

Auxin and plant morphogenesis - a model of regulation

Directory of Open Access Journals (Sweden)

Stefan Zajączkowski

2015-01-01

Full Text Available In the presented model cells of the plant body form a spatial medium in which three-dimensional morphogenic waves of auxin are propagated. Points in the same phase of oscillation form isophasic surfaces and the vectors of wave propagation form a three-dimensional vector field. The vectors in the case of local inhomogeneities of the medium deviate from organ polarity, providing positional information recognized by cells. Models of functioning of such a supracellular oscillatory system in regulation of tissue differentiation, tropic responses and plant form are discussed.

A Situated Perspective on the regulation of practice

DEFF Research Database (Denmark)

Pedersen, Martin

2012-01-01

, considered a problem-free course of events. Arguing from a situated perspective, this paper will demonstrate that this is not always the case. Owing to the situated nature of actions, the drawings cannot be understood as the pivotal tool for restraining the construction practice; instead they are resources...... for meaningful actions. It is argued that the construction practice is better understood as constituted and regulated as a matter of reciprocal “give-and-take” relations between participants in different professions. These give-and-take relations are based in the continual negotiations that take place between...

Local regulation between formal and informal institutions: analysis by application to the case of the town of Ksar-Hellal (Tunisia

Directory of Open Access Journals (Sweden)

Makram GAALICHE

2013-06-01

Full Text Available The purpose of this paper is to detect the relevance degrees of formal and informal institutions at the level of local regulation, as well as their effects on the local companies’ productivity. Indeed, by analyzing the territory of the Ksar-Hellal town, we noted that informal institutions, apprehended by trust and collective punishment, contribute with the formal penal institutions to channel the behavior of Hilalian companies but with less effectiveness. Similarly, the strong contribution of exogenous institutions in boosting productivity compared to that of the endogenous ones states that decision makers should improve the quality of formal regulation and this at the expense of any form of regulation built by values commonly shared by the local community.

‘Standard’ incentive regulation hinders the integration of renewable energy generation

International Nuclear Information System (INIS)

Nykamp, Stefan; Andor, Mark; Hurink, Johann L.

2012-01-01

The connection and distribution of growing, decentralized electricity generation from renewable energy sources (RES-E) is leading to massive investment needs. Besides investing in additional ‘conventional’ assets (e.g. cables), grid operators can also invest in innovative ‘smart solutions’ like local storage capacities or voltage regulation appliances, which may be a more suitable way of integrating RES-E. This paper investigates the influence of incentive regulation on the investment decision of grid operators to integrate RES-E. We describe the technical and regulatory background, explain the advantages of ‘smart solutions’ and present an approach for comparing investment scenarios. As an example, we calculate the profitability of investments in a case study of the German electricity market. We apply Data Envelopment Analysis (DEA) and Stochastic Frontier Analysis (SFA) to show the influence of the investment alternatives on grid operator efficiency objectives. We demonstrate that under current ‘standard’ incentive regulation, the grid operators gain profitability by avoiding investments and – if they are forced to invest – by not implementing ‘smart solutions’. The results highlight the need to consider innovation in the regulation design. Further research should investigate specific instruments that can be used to account for innovation. Our brief discussion of such instruments provides a starting point. - Highlights: ► We measure the influence of investments on efficiency by applying DEA and SFA. ► We compare the profitability of alternative investments under incentive regulation. ► Incentive regulation gives incentives to refuse investment at all. ► If DSOs are forced to invest, reinforcement is preferable to smart solutions. ► Ways to consider innovation in incentive regulations are required and discussed.

Information Processing in Auto-regulated Systems

Directory of Open Access Journals (Sweden)

Karl Javorszky

2003-06-01

Full Text Available Abstract: We present a model of information processing which is based on two concurrent ways of describing the world, where a description in one of the languages limits the possibilities for realisations in the other language. The two describing dimensions appear in our common sense as dichotomies of perspectives: subjective - objective; diversity - similarity; individual - collective. We abstract from the subjective connotations and treat the test theoretical case of an interval on which several concurrent categories can be introduced. We investigate multidimensional partitions as potential carriers of information and compare their efficiency to that of sequenced carriers. We regard the same assembly once as a contemporary collection, once as a longitudinal sequence and find promising inroads towards understanding information processing by auto-regulated systems. Information is understood to point out that what is the case from among alternatives, which could be the case. We have translated these ideas into logical operations on the set of natural numbers and have found two equivalence points on N where matches between sequential and commutative ways of presenting a state of the world can agree in a stable fashion: a flip-flop mechanism is envisioned. By following this new approach, a mathematical treatment of some poignant biomathematical problems is allowed. Also, the concepts presented in this treatise may well have relevance and applications within the information processing and the theory of language fields.

Water use conflicts in northern Tanzania. A case study of Rundugai ...

African Journals Online (AJOL)

A case study of Rundugai river catchment, Pangani basin Hzai District. ... content and structural-functional analysis techniques were used for qualitative data analysis. Five types of key stakeholders/actors involved in regulating and negotiating ...

Successful New Product Development by Optimizing Development Process Effectiveness in Highly Regulated Sectors: The Case of the Spanish Medical Devices Sector

NARCIS (Netherlands)

Pullen, A.J.J.; Cabello-Medina, Carmen; de Weerd-Nederhof, Petronella C.; Visscher, Klaasjan; Groen, Arend J.; Tschirky, H.; Herstatt, C.; Probert, D.; Gemunden, H.G.; Colombo, M.G.; Durand, T.; de Weerd-Nederhof, P.C.; Schweisfurth, T.

2010-01-01

Rapid development and commercialization of new products is of vital importance for small and medium sized enterprises (SME) in regulated sectors. Due to strict regulations, competitive advantage can hardly be achieved through the effectiveness of product concepts only. If an SME in a highly

The role of private speech in cognitive regulation of learners: The case of English as a foreign language education

Directory of Open Access Journals (Sweden)

Mohamad Reza Anani Sarab

2015-12-01

Full Text Available Investigations into the use of private speech by adult English foreign language (EFL learners in regulating their mental activities have been an interesting area of research with a sociocultural framework. Following this line of research, 30 advanced adult EFL learners were selected via the administration of Oxford quick placement test and took a test of solving challenging English riddles while their voices were being recorded. Later, instances of the produced private speech were analyzed in terms of form, content, and function. It was demonstrated that private speech with its different forms, contents, and functions plays a very crucial role in cognitive regulation of EFL learners which has important implications for the context of language learning classrooms. In addition, participants seemed to produce qualitatively different kinds of L2 private speech, which brought us to the conclusion that it would be necessary to consider quality and not just quantity in studying psycholinguistic concepts, such as cognitive regulation and private speech.

The shaping of environmental concern in product chains: analysing Danish case studies on environmental aspects in product chain relations

DEFF Research Database (Denmark)

Forman, Marianne; Hansen, Anne Grethe; Jørgensen, Michael Søgaard

indirect demand for greening activities. The analysis shows the co-construction of environmental concerns and demands, companies’ environmental practices and technological developments, and their stabilisation in the supply chain. The case studies also point to how the greening of frontrunners might make...... the systems of production, consumption, knowledge and regulation are discussed. The role of boundary objects is discussed with eco-labelling as case. The role of and the impact on the product chain relations are analysed as part of these mechanisms. From the case studies, green innovations in the product...... chain, which the case company represents, are identified. Direct customer and regulatory demands, as well as indirect societal and regulatory demands are mapped, and their role for product chain greening analysed. The case studies point to the importance of customer demand, regulation and potentially...

The particularities of vegetative regulation of central haemodynamic at children living in condition of chronic radiation and chemical influence in low doses

International Nuclear Information System (INIS)

Zherko, O.M.

2000-01-01

398 children 7-16 years old living in condition of environmental threats have been examined. The most essential changes of the vegetative regulation of central haemodynamic have been found at children 7-13 years old. The distortion of vegetative regulation of the central haemodynamic have been revealed: sympatcotonia in case of arterial hypotensia and deficiency of sympathetic regulation of arterial hypertensia. Level of hormones of the sympatoadrenality system was fall. (authors)

Competition between bank regulators

OpenAIRE

Schindler, Dirk; Eggert, Wolfgang

2004-01-01

This paper examines competition between bank regulators in open economies. We use a model where credit demand of firms is endogenous and show any tendency for downward competition in regulation policy is limited by the effect of regulation on profits of nonfinancial firms. Moreover, perfect mobility on loans and deposit markets fully eliminates the incentives of regulators to set bank regulation at ine±cient low levels.

The role of oligomerization and cooperative regulation in protein function: the case of tryptophan synthase.

Directory of Open Access Journals (Sweden)

M Qaiser Fatmi

Full Text Available The oligomerization/co-localization of protein complexes and their cooperative regulation in protein function is a key feature in many biological systems. The synergistic regulation in different subunits often enhances the functional properties of the multi-enzyme complex. The present study used molecular dynamics and Brownian dynamics simulations to study the effects of allostery, oligomerization and intermediate channeling on enhancing the protein function of tryptophan synthase (TRPS. TRPS uses a set of α/β-dimeric units to catalyze the last two steps of L-tryptophan biosynthesis, and the rate is remarkably slower in the isolated monomers. Our work shows that without their binding partner, the isolated monomers are stable and more rigid. The substrates can form fairly stable interactions with the protein in both forms when the protein reaches the final ligand-bound conformations. Our simulations also revealed that the α/β-dimeric unit stabilizes the substrate-protein conformation in the ligand binding process, which lowers the conformation transition barrier and helps the protein conformations shift from an open/inactive form to a closed/active form. Brownian dynamics simulations with a coarse-grained model illustrate how protein conformations affect substrate channeling. The results highlight the complex roles of protein oligomerization and the fine balance between rigidity and dynamics in protein function.

Emotion and self-regulation in deliberate personal change: A case study analysis

OpenAIRE

Lopes, Paulo Nuno; Coyle, Adrian; Gallie, Jack

2014-01-01

Two young adults’ experiences of deliberate personal change in the realms of study habits and social interaction were examined using a qualitative, interview-based case study approach. Both talked about an aspect of their behavior that they had changed and one that they would like to change. Thematic analysis was used to interpret their stories and reach an integrative and contextualized understanding of their individual developmental trajectories. Our analysis explored the use of motivated r...

Management practices in Australasian ethical investment products: a role for regulation?

DEFF Research Database (Denmark)

Haigh, Matthew; Guthrie, James

2010-01-01

This paper adds to the literatures on socially responsible investment (SRI), investment management, regulation of financial services and social accounting by providing a comprehensive survey of investment methods used in SRI products and regulated social reporting in financial services. Australian...... a four-year period: 2004-2007. These aspects were further examined in 18 case studies. Over the period, diversity and intensity of construction methods had increased both within and between investment managers. The non-standard nature of management consultation used in SRI products, marketing needs...... debates and other public reports. Portfolio construction styles of 86 SRI products managed by 63 financial institutions in Australia and New Zealand were chosen for analysis. Statistical analysis was conducted to identify associations between styles, construction methods and assessment techniques over...

Problems and Prospects: Public Health Regulation of Dietary Supplements.

Science.gov (United States)

Binns, Colin W; Lee, Mi Kyung; Lee, Andy H

2018-04-01

Dietary supplements are a global business worth more than US$100 billion annually. These supplements are taken by up to 50% of adults and perhaps one-third of children in economically advanced economies. Definitions of dietary supplements differ from country to country, and regulation is generally lax and often seems to be directed more toward promoting commerce than protecting public health. Supplements may directly cause toxic reactions or may interact with other supplements or pharmaceuticals. Some supplements are found to have been contaminated with heavy metals, and others do not contain the expected quantities of active ingredients. In general, supplements are not needed except in cases of established deficiencies, and excess of some nutrients can increase cancer rates. There are important public health reasons for taking some supplements, including folate and iodine in pregnancy. This review discusses the public health concerns associated with dietary supplements and suggests directions for further regulation.

Kidney Sales and Market Regulation: A Reply to Semrau.

Science.gov (United States)

Koplin, Julian J

2017-11-15

Luke Semrau argues that the documented harms of existing organ markets do not undermine the case for establishing regulated systems of paid kidney donation. He offers two arguments in support of this conclusion. First, Semrau argues that the harms of kidney selling are straightforwardly amenable to regulatory solution. Second, Semrau argues that even in existing black markets, sellers would likely have experienced greater harm if the option of selling a kidney were not available. This commentary challenges both of Semrau's claims. I argue that there is no reason to believe that kidney sellers benefit from the current black market trade in organs, and highlight a number of potential issues regarding the effectiveness and feasibility of Semrau's proposed market regulations. © The Author 2017. Published by Oxford University Press, on behalf of the Journal of Medicine and Philosophy Inc. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Pre-Service Teachers' Defensive Pessimism in Situ: Two Case Studies within a Mathematics Classroom

Science.gov (United States)

Merz, Alice H.; Swim, Terri Jo

2008-01-01

In this study, defensive pessimism is reviewed in relation to anxiety, self-esteem, expectations, self-regulation, and self-handicapping. Then, two case studies of American pre-service teachers in a mathematics classroom are provided that move the research beyond survey and correlational studies. In the case analyses, defensive pessimists'…

DMBT1 expression is down-regulated in breast cancer

International Nuclear Information System (INIS)

Braidotti, P; Pietra, GG; Nuciforo, PG; Mollenhauer, J; Poustka, A; Pellegrini, C; Moro, A; Bulfamante, G; Coggi, G; Bosari, S

2004-01-01

We studied the expression of DMBT1 (deleted in malignant brain tumor 1), a putative tumor suppressor gene, in normal, proliferative, and malignant breast epithelium and its possible relation to cell cycle. Sections from 17 benign lesions and 55 carcinomas were immunostained with anti DMBT1 antibody (DMBTh12) and sections from 36 samples, were double-stained also with anti MCM5, one of the 6 pre-replicative complex proteins with cell proliferation-licensing functions. DMBT1 gene expression at mRNA level was assessed by RT-PCR in frozen tissues samples from 39 patients. Normal glands and hyperplastic epithelium in benign lesions displayed a luminal polarized DMBTh12 immunoreactivity. Normal and hyperplastic epithelium adjacent to carcinomas showed a loss of polarization, with immunostaining present in basal and perinuclear cytoplasmic compartments. DMBT1 protein expression was down-regulated in the cancerous lesions compared to the normal and/or hyperplastic epithelium adjacent to carcinomas (3/55 positive carcinomas versus 33/42 positive normal/hyperplastic epithelia; p = 0.0001). In 72% of cases RT-PCR confirmed immunohistochemical results. Most of normal and hyperplastic mammary cells positive with DMBTh12 were also MCM5-positive. The redistribution and up-regulation of DMBT1 in normal and hyperplastic tissues flanking malignant tumours and its down-regulation in carcinomas suggests a potential role in breast cancer. Moreover, the concomitant expression of DMTB1 and MCM5 suggests its possible association with the cell-cycle regulation

Canada's Patented Medicine Notice of Compliance regulations: balancing the scales or tipping them?

Directory of Open Access Journals (Sweden)

Lexchin Joel

2011-03-01

Full Text Available Abstract Background In order to comply with the provisions of the North American Free Trade Agreement, in 1993 the Canadian federal government introduced the Patented Medicine Notice of Compliance Linkage Regulations. These regulations were meant to achieve a balance between the timely entry of generic medicines and the rights of patent holders. The regulations tied the regulatory approval of generic medicines to the patent status of the original brand-name product. Discussion Since their introduction the regulations have been a source of contention between the generic and the brand-name industry. While the regulations have generated a considerable amount of work for the Federal Court of Canada both sides dispute the interpretation of the "win rate" in the court cases. Similarly, there is no agreement on whether multiple patents on single drugs represent a legitimate activity by the brand-name industry or an "evergreening" tactic. The generic industry's position is that the regulations are being abused leading to the delay in the introduction of lower cost generic products by as much as 8 years. The brand-name companies counter that the regulations are necessary because injunctions against the introduction of generic products are frequently unavailable to them. The regulations were amended in 2006 and again in 2008 but both sides continue to claim that the regulations favour the other party. The battle around the regulations also has an international dimension with interventions by PhRMA, the trade association representing the United States based multinational companies, arguing that the regulations are not stringent enough and that Canada needs to be placed on the U.S. Priority Watch List of countries. Finally, there are multiple costs to Canadian society as a result of the NOC regulations. Summary Despite the rhetoric there has been almost no empiric academic research done into the effect of the regulations. In order to develop rational policy

Grandma's TUM-my Trouble: A Case Study in Renal Physiology and Acid-Base Balance

Science.gov (United States)

Massey, Ann T.

2015-01-01

This case study involves the role of the kidneys in regulating blood pH and electrolytes. The case was used near the end of a two-semester Human Anatomy and Physiology course sequence, during the time when renal physiology was under study. Groups of two to three students were given the case and associated information (lab values, etc.). Students…

Power variation and frequency regulation. Adaptation of PWR plant possibilities to the network needs

International Nuclear Information System (INIS)

Baboulin, J.P.; Burger, M.

1980-01-01

When the PWR are an important part of the power installed on a network, and that will be the case of the EDF network in the coming years, the participation of those plants to the power regulating becomes a necessity for the operating staff. This load regulating includes: daily variations of high amplitude; a permanent frequency - power regulating. The first part of the communication shows the network exploitation principles, and the resulting power variations concerning the existing nuclear power plants. Such transients are leading to stresses on fuel. The second part of the communication reports about the test program engaged by EDF in collaboration with the CEA and FRAMATOME, in order to study the fuel behaviour in real power conditions and power cycles, and that, just to the operational burn up of this fuel. (author)

USE OF ELECTRONIC CASE HISTORIES IN OPERATION OF MEDICAL UNITS

Directory of Open Access Journals (Sweden)

I. B. Boltenkova

2016-01-01

Full Text Available Introduction of electronic case histories to medical units including TB units is one of the factors allowing enhancing quality of medical care provision. Use of the electronic case histories provides conditions for information transparency improvement in a medical unit: financial, statistic and medico-technological. Information contained in the electronic case history is important and required both for internal and external use. Use of electronic case histories contributes to reduction of labor costs of workers in medical units, provides fast access of medical personnel to information, formalizes data, provides preservation, invariance and reliability of the information entered into electronic case history during the whole period of storage, regulates the access rights and confidentiality, personifies data and allows unifying health data of all Russian population into one pool.

78 FR 31551 - Federal Acquisition Regulation; Submission for OMB Review; Commerce Patent Regulations

Science.gov (United States)

2013-05-24

...; Submission for OMB Review; Commerce Patent Regulations AGENCIES: Department of Defense (DOD), General... collection requirement concerning Department of Commerce patent regulations. A notice was published in...- 0095, Commerce Patent Regulations, by any of the following methods: Regulations.gov : http://www...

Connections Between Future Time Perspectives and Self-Regulated Learning for Mid-Year Engineering Students: A Multiple Case Study

Science.gov (United States)

Chasmar, Justine

This dissertation presents multiple studies with the purpose of understanding the connections between undergraduate engineering students' motivations, specifically students' Future Time Perspectives (FTPs) and Self-Regulated Learning (SRL). FTP refers to the views students hold about the future and how their perceptions of current tasks are affected by these views. SRL connects the behaviors, metacognition, and motivation of students in their learning. The goals of this research project were to 1) qualitatively describe and document engineering students' SRL strategies, 2) examine interactions between engineering students' FTPs and SRL strategy use, and 3) explore goal-setting as a bridge between FTP and SRL. In an exploratory qualitative study with mid-year industrial engineering students to examine the SRL strategies used before and after an SRL intervention, results showed that students intended to use more SRL strategies than they attempted. However, students self-reported using new SRL strategies from the intervention. Students in this population also completed a survey and a single interview about FTP and SRL. Results showed perceptions of instrumentality of coursework and skills as motivation for using SRL strategies, and a varied use of SRL strategies for students with different FTPs. Overall, three types of student FTP were seen: students with a single realistic view of the future, conflicting ideal and realistic future views, or open views of the future. A sequential explanatory mixed methods study was conducted with mid-year students from multiple engineering majors. First a cluster analysis of survey results of FTP items compared to FTP interview responses was used for participant selection. Then a multiple case study was conducted with data collected through surveys, journal entries, course performance, and two interviews. Results showed that students with a well-defined FTP self-regulated in the present based on their varied perceptions of

Regulatory limits in radiation injury cases

International Nuclear Information System (INIS)

Charnoff, G.

1980-01-01

Recent developments in the application of the principles of tort, and the impact of governmental regulations on tort law in the U.S.A. are summarised in relation to the following 1979 events raising the issue of liability for radiation injuries: Three Mile Island accident, the Karen Silkwood trial, nuclear weapons testing exposure cases, the use of uranium tailings in residential construction, and radon gas collected in old copper mines. (U.K.)

Interpersonal emotion regulation.

Science.gov (United States)

Zaki, Jamil; Williams, W Craig

2013-10-01

Contemporary emotion regulation research emphasizes intrapersonal processes such as cognitive reappraisal and expressive suppression, but people experiencing affect commonly choose not to go it alone. Instead, individuals often turn to others for help in shaping their affective lives. How and under what circumstances does such interpersonal regulation modulate emotional experience? Although scientists have examined allied phenomena such as social sharing, empathy, social support, and prosocial behavior for decades, there have been surprisingly few attempts to integrate these data into a single conceptual framework of interpersonal regulation. Here we propose such a framework. We first map a "space" differentiating classes of interpersonal regulation according to whether an individual uses an interpersonal regulatory episode to alter their own or another person's emotion. We then identify 2 types of processes--response-dependent and response-independent--that could support interpersonal regulation. This framework classifies an array of processes through which interpersonal contact fulfills regulatory goals. More broadly, it organizes diffuse, heretofore independent data on "pieces" of interpersonal regulation, and identifies growth points for this young and exciting research domain.

The meta-governance of organic seed regulation in the USA, European Union and Mexico

NARCIS (Netherlands)

Renaud, Erica; Lammerts van Bueren, Edith; Jiggins, Janice

2016-01-01

Seed governance in agriculture is a challenging global issue. This paper analyses the evolution of organic seed regulation in the USA, the European Union and Mexico as model cases of how these challenges are being addressed, based on a study conducted between 2007 and 2014. It highlights how

Volume regulation in epithelia

DEFF Research Database (Denmark)

Larsen, Erik Hviid; Hoffmann, Else Kay

2016-01-01

to amphibian skin and mammalian cortical collecting tubule of low and intermediate osmotic permeability. Crosstalk between entrance and exit mechanisms interferes with volume regulation both at aniso-osmotic and iso-osmotic volume perturbations. It has been proposed that cell volume regulation is an intrinsic...... regulation are cloned. The volume-regulated anion channel (VRAC) exhibiting specific electrophysiological characteristics seems exclusive to serve cell volume regulation. This is contrary to K+ channels as well as cotransporters and exchange mechanisms that may serve both transepithelial transport and cell...... volume regulation. In the same cell, these functions may be maintained by different ion pathways that are separately regulated. RVD is often preceded by increase in cytosolic free Ca2+, probably via influx through TRP channels, but Ca2+ release from intracellular stores has also been observed. Cell...

Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira

Science.gov (United States)

Adhikarla, Haritha; Wunder, Elsio A.; Mechaly, Ariel E.; Mehta, Sameet; Wang, Zheng; Santos, Luciane; Bisht, Vimla; Diggle, Peter; Murray, Gerald; Adler, Ben; Lopez, Francesc; Townsend, Jeffrey P.; Groisman, Eduardo; Picardeau, Mathieu; Buschiazzo, Alejandro; Ko, Albert I.

2018-01-01

Leptospirosis is an emerging zoonotic disease with more than 1 million cases annually. Currently there is lack of evidence for signaling pathways involved during the infection process of Leptospira. In our comprehensive genomic analysis of 20 Leptospira spp. we identified seven pathogen-specific Two-Component System (TCS) proteins. Disruption of two these TCS genes in pathogenic Leptospira strain resulted in loss-of-virulence in a hamster model of leptospirosis. Corresponding genes lvrA and lvrB (leptospira virulence regulator) are juxtaposed in an operon and are predicted to encode a hybrid histidine kinase and a hybrid response regulator, respectively. Transcriptome analysis of lvr mutant strains with disruption of one (lvrB) or both genes (lvrA/B) revealed global transcriptional regulation of 850 differentially expressed genes. Phosphotransfer assays demonstrated that LvrA phosphorylates LvrB and predicted further signaling downstream to one or more DNA-binding response regulators, suggesting that it is a branched pathway. Phylogenetic analyses indicated that lvrA and lvrB evolved independently within different ecological lineages in Leptospira via gene duplication. This study uncovers a novel-signaling pathway that regulates virulence in pathogenic Leptospira (Lvr), providing a framework to understand the molecular bases of regulation in this life-threatening bacterium. PMID:29600195

Regulations for the transport of radioactive material in Italy: the role of the Italian Competent Authority (ANPA)

International Nuclear Information System (INIS)

Orsini, A.; Trivelloni, S.

1995-01-01

In Italy four Ministries, Industry, Transport, Marine Merchandise and Interior, have the legal responsibility to issue and apply the transport safety regulations for radioactive material. ANPA, the National Agency for Environmental Protection, has the technical duty to issue the approval certificates and to support the various Ministries in authorizing carriers for all modes of transport, in updating the regulations and advising in the case of emergency conditions. ANPA is monitoring the quantity of radioactive material transported in Italy, the radiation doses of workers and public, and verifying the implementation of transport regulations through inspections of the carriers and during storage in transit and handling. (Author)

Regulations for the transport of radioactive material in Italy: the role of the Italian Competent Authority (ANPA)

International Nuclear Information System (INIS)

Orsini, A.; Trivelloni, S.

1995-01-01

In Italy four Ministries, Industry, Transport, Marine Merchandise and Interior, have the legal responsibility to issue and apply the transport safety regulations for radioactive material. ANPA, the National Agency for Environmental Protection, has the technical duty to issue the approval certificates and to support the various Ministries in authorising carriers for all modes of transport, in updating the regulations and advising in the case of emergency conditions. ANPA is monitoring the quantity of radioactive material transported in Italy, the radiation doses of workers and public, and verifying the implementation of transport regulations through inspection of the carriers and during storage in transit and handling. (author)