The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster.

Science.gov (United States)

Baumgartner, Roland; Stocker, Hugo; Hafen, Ernst

2013-01-01

Appropriate expression of growth-regulatory genes is essential to ensure normal animal development and to prevent diseases like cancer. Gene regulation at the levels of transcription and translational initiation mediated by the Hippo and Insulin signaling pathways and by the TORC1 complex, respectively, has been well documented. Whether translational control mediated by RNA-binding proteins contributes to the regulation of cellular growth is less clear. Here, we identify Lingerer (Lig), an UBA domain-containing protein, as growth suppressor that associates with the RNA-binding proteins Fragile X mental retardation protein 1 (FMR1) and Caprin (Capr) and directly interacts with and regulates the RNA-binding protein Rasputin (Rin) in Drosophila melanogaster. lig mutant organs overgrow due to increased proliferation, and a reporter for the JAK/STAT signaling pathway is upregulated in a lig mutant situation. rin, Capr or FMR1 in combination as double mutants, but not the respective single mutants, display lig like phenotypes, implicating a redundant function of Rin, Capr and FMR1 in growth control in epithelial tissues. Thus, Lig regulates cell proliferation during development in concert with Rin, Capr and FMR1.

Detecting bacterial magnetite in sediments: strengths and limitations of FMR spectroscopy

Science.gov (United States)

Winklhofer, M.

2012-04-01

Ferromagnetic resonance spectroscopy (FMR) is increasingly being used as a diagnostic tool for identifying bacterial magnetite in sediments [e.g., Kopp et al. 2007; Kind et al. 2011, Roberts et al. 2011 ], the reason being that magnetic bacteria have a characteristic FMR fingerprint which is not known from inorganic geological samples [Kopp & Kirschvink, 2008]. The diagnostic FMR features of single-stranded magnetite chains are a g-value 2, quite opposite to what we know from single-stranded chains. Therefore, in order to better understand possible biogenic FMR fingerprints and to refine the screen, there is a clear need to acquire FMR spectra of magnetic bacteria with different chain configurations and, in particular, of greigite producing bacteria.

A nonsense mutation in FMR1 causing fragile X syndrome

DEFF Research Database (Denmark)

Grønskov, Karen; Brøndum-Nielsen, Karen; Dedic, Alma

2011-01-01

Fragile X syndrome is a common cause of inherited intellectual disability. It is caused by lack of the FMR1 gene product FMRP. The most frequent cause is the expansion of a CGG repeat located in the 5'UTR of FMR1. Alleles with 200 or more repeats become hypermethylated and transcriptionally silent....... Only few patients with intragenic point mutations in FMR1 have been reported and, currently, routine analysis of patients referred for fragile X syndrome includes solely analysis for repeat expansion and methylation status. We identified a substitution in exon 2 of FMR1, c.80C>A, causing a nonsense...... mutation p.Ser27X, in a patient with classical clinical symptoms of fragile X syndrome. The mother who carried the mutation in heterozygous form presented with mild intellectual impairment. We conclude that further studies including western blot and DNA sequence analysis of the FMR1 gene should...

Influence of the fragile X mental retardation (FMR1) gene on the brain and working memory in men with normal FMR1 alleles

OpenAIRE

Wang, Jun Yi; Hessl, David; Iwahashi, Christine; Cheung, Katherine; Schneider, Andrea; Hagerman, Randi J.; Hagerman, Paul J.; Rivera, Susan M.

2012-01-01

The fragile X mental retardation 1 (FMR1) gene plays an important role in the development and maintenance of neuronal circuits that are essential for cognitive functioning. We explored the functional linkage(s) among lymphocytic FMR1 gene expression, brain structure, and working memory in healthy adult males. We acquired T1-weighted and diffusion tensor imaging from 34 males (18–80 years, mean ± SD = 43.6 ± 18.4 years) with normal FMR1 alleles and performed genetic and working memory assessme...

Use of electronic bulletin boards for environmental management

International Nuclear Information System (INIS)

Kumar, A.; Rao, H.G.

1991-01-01

As a result of changes to existing environmental protection legislation, and the numerous changes to existing regulations that continually take place, environmental managers need updated information on federal mandated programs and regulation, approved and other mathematical models, control technologies, acceptable measurement techniques and continuing education courses. The US Environmental Protection Agency (EPA) is providing help to state and local air pollution control agencies, the regulated community, consultants and the general public through electronic bulletin boards. Each bulletin board (BB) uses data base management system and communication technology to provide access to information on several specific topics of interest to the environmental manager. This review discusses nine bulletin board systems available to the public from the EPA. Several alternative bulletin board systems are also available and will be discussed in future columns

Clinical, molecular, and pharmacological aspects of FMR1 related disorders.

Science.gov (United States)

Pugin, A; Faundes, V; Santa María, L; Curotto, B; Aliaga, S; Salas, I; Soto, P; Bravo, P; Peña, M I; Alliende, M A

2017-05-01

Fragile X syndrome, the most common inherited cause of intellectual disability, is associated with a broad spectrum of disorders across different generations of a single family. This study reviews the clinical manifestations of fragile X-associated disorders as well as the spectrum of mutations of the fragile X mental retardation 1 gene (FMR1) and the neurobiology of the fragile X mental retardation protein (FMRP), and also provides an overview of the potential therapeutic targets and genetic counselling. This disorder is caused by expansion of the CGG repeat (>200 repeats) in the 5 prime untranslated region of FMR1, resulting in a deficit or absence of FMRP. FMRP is an RNA-binding protein that regulates the translation of several genes that are important in synaptic plasticity and dendritic maturation. It is believed that CGG repeat expansions in the premutation range (55 to 200 repeats) elicit an increase in mRNA levels of FMR1, which may cause neuronal toxicity. These changes manifest clinically as developmental problems such as autism and learning disabilities as well as neurodegenerative diseases including fragile X-associated tremor/ataxia syndrome (FXTAS). Advances in identifying the molecular basis of fragile X syndrome may help us understand the causes of neuropsychiatric disorders, and they will probably contribute to development of new and specific treatments. Copyright © 2014 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.

Brief Report: Altered Social Behavior in Isolation-Reared "Fmr1" Knockout Mice

Science.gov (United States)

Heitzer, Andrew M.; Roth, Alexandra K.; Nawrocki, Lauren; Wrenn, Craige C.; Valdovinos, Maria G.

2013-01-01

Social behavior abnormalities in Fragile X syndrome (FXS) are characterized by social withdrawal, anxiety, and deficits in social cognition. To assess these deficits, a model of FXS, the "Fmr1" knockout mouse ("Fmr1" KO), has been utilized. This mouse model has a null mutation in the fragile X mental retardation 1 gene ("Fmr1") and displays…

Nonlinear FMR spectra in yttrium iron garnet

Directory of Open Access Journals (Sweden)

Yu.M. Bunkov, P.M. Vetoshko, I.G. Motygullin, T.R. Safin, M.S. Tagirov, N.A. Tukmakova

2015-12-01

Full Text Available Results of demagnetizing effect studies in yttrium iron garnet Y3Fe5O12 thin films are reported. Experiments were performed on X-Band of electron paramagnetic resonance spectrometer at room temperature. The ferromagnetic resonance (FMR spectra were obtained for one-layer single crystal YIG films for different values of the applied microwave power. Nonlinear FMR spectra transformation by the microwave power increasing in various directions of magnetic field sweep was observed. It is explained by the influence of the demagnetization action of nonequilibrium magnons.

41 CFR 102-2.140 - What elements of plain language appear in the FMR?

Science.gov (United States)

2010-07-01

... MANAGEMENT REGULATION SYSTEM Plain Language Regulatory Style § 102-2.140 What elements of plain language... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What elements of plain language appear in the FMR? 102-2.140 Section 102-2.140 Public Contracts and Property Management Federal...

Resilience to audiogenic seizures is associated with p-ERK1/2 dephosphorylation in the subiculum of Fmr1 knockout mice

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Giulia eCuria

2013-04-01

Full Text Available Young, but not adult, Fmr1 knockout (KO mice display audiogenic seizures (AGS that can be prevented by inhibiting extracellular signal-regulated kinases 1/2 (ERK1/2 phosphorylation. In order to identify the cerebral regions involved in these phenomena, we characterized the response to AGS in Fmr1 KO mice and wild type (WT controls at postnatal day (P 45 and P90. To characterize the diverse response to AGS in various cerebral regions, we evaluated the activity markers FosB/ΔFosB and phosphorylated ERK1/2 (p-ERK1/2. Wild running (100% of tested mice followed by clonic/tonic seizures (30% were observed in P45 Fmr1 KO mice, but not in WT mice. In P90 Fmr1 KO mice, wild running was only present in 25% of tested animals. Basal FosB/ΔFosB immunoreactivity was higher (P<0.01 vs WT in the CA1 and subiculum of P45 Fmr1 KO mice. Following the AGS test, FosB/ΔFosB expression consistently increased in most of the analyzed regions in both groups at P45, but not at P90. Interestingly, FosB/ΔFosB immunoreactivity was significantly higher in P45 Fmr1 KO mice in the medial geniculate body (P<0.05 vs WT and CA3 (P<0.01. Neurons presenting with immunopositivity to p-ERK1/2 were more abundant in the subiculum of Fmr1 KO mice in control condition (P<0.05 vs WT, in both age groups. In this region, p-ERK1/2-immunopositive cells significantly decreased (-75%, P<0.01 in P90 Fmr1 KO mice exposed to the AGS test, but no changes were found in P45 mice or in other brain regions. In both age groups of WT mice, p-ERK1/2-immunopositive cells increased in the subiculum after exposure to the acoustic test. Our findings illustrate that FosB/ΔFosB markers are overexpressed in the medial geniculate body and CA3 in Fmr1 KO mice experiencing AGS, and that p-ERK1/2 is markedly decreased in the subiculum of Fmr1 KO mice resistant to AGS induction. These findings suggest that resilience to AGS is associated with dephosphorylation of p-ERK1/2 in the subiculum of mature Fmr1 KO mice.

Low-Normal FMR1 CGG Repeat Length: Phenotypic Associations

Directory of Open Access Journals (Sweden)

Marsha eMailick

2014-09-01

Full Text Available This population-based study investigates genotype-phenotype correlations of low-normal CGG repeats in the fragile X mental retardation 1 (FMR1 gene. FMR1 plays an important role in brain development and function, and encodes FMRP (fragile X mental retardation protein, an RNA-binding protein that regulates protein synthesis impacting activity-dependent synaptic development and plasticity. Most past research has focused on CGG premutation expansions (41 to 200 CGG repeats and on fragile X syndrome (200+ CGG repeats, with considerably less attention on the other end of the spectrum of CGG repeats. Using existing data, older adults with 23 or fewer CGG repeats (2 SDs below the mean were compared with age-peers who have normal numbers of CGGs (24-40 with respect to cognition, mental health, cancer, and having children with disabilities. Men (n = 341 with an allele in the low-normal range and women (n = 46 with two low-normal alleles had significantly more difficulty with their memory and ability to solve day to day problems. Women with both FMR1 alleles in the low-normal category had significantly elevated odds of feeling that they need to drink more to get the same effect as in the past. These women also had two and one-half times the odds of having had breast cancer and four times the odds of uterine cancer. Men and women with low-normal CGGs had higher odds of having a child with a disability, either a developmental disability or a mental health condition. These findings are in line with the hypothesis that there is a need for tight neuronal homeostatic control mechanisms for optimal cognitive and behavioral functioning, and more generally that low numbers as well as high numbers of CGG repeats may be problematic for health.

41 CFR 102-2.145 - To what do pronouns refer when used in the FMR?

Science.gov (United States)

2010-07-01

... MANAGEMENT REGULATION SYSTEM Plain Language Regulatory Style § 102-2.145 To what do pronouns refer when used... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false To what do pronouns refer when used in the FMR? 102-2.145 Section 102-2.145 Public Contracts and Property Management Federal...

PSP-CBS with Dopamine Deficiency in a Female with a FMR1 Premutation.

Science.gov (United States)

Paucar, Martin; Beniaminov, Stanislav; Paslawski, Wojciech; Svenningsson, Per

2016-10-01

Premutations in the fragile X mental retardation 1 (FMR1) gene cause fragile X-associated tremor/ataxia syndrome (FXTAS) and FMR1-related primary ovarian insufficiency (POI). Female FMR1 premutation carriers rarely develop motor features. Dual pathology is an emerging phenomenon among FMR1 premutation carriers. Here, we describe a family affected by FMR1-related disorders in which the female index case has developed a rapidly progressive and disabling syndrome of atypical parkinsonism. This syndrome consists of early onset postural instability, echolalia, dystonia, and varying types of apraxia like early onset orobuccal apraxia and oculomotor apraxia. She has also developed supranuclear gaze palsy, increased latency of saccade initiation, and slow saccades. These features are compatible with progressive supranuclear palsy (PSP) of a corticobasal syndrome (CBS) variant. Imaging displays a marked reduction of presynaptic dopaminergic uptake and cerebrospinal fluid analysis showed reduced dopamine metabolism; however, the patient is unresponsive to levodopa. Midbrain atrophy ("hummingbird sign") and mild cerebellar atrophy were found on brain MRI. Her father was affected by a typical FXTAS presentation but also displayed dopamine deficiency along with the hummingbird sign. The mechanisms by which FMR1 premutations predispose to atypical parkinsonism and dopamine deficiency await further elucidation.

Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse.

Science.gov (United States)

Sørensen, Emilie M; Bertelsen, Freja; Weikop, Pia; Skovborg, Maria M; Banke, Tue; Drasbek, Kim R; Scheel-Krüger, Jørgen

2015-12-01

The aims of this study were to investigate behaviour relevant to human autism spectrum disorder (ASD) and the fragile X syndrome in adolescent Fmr1 knockout (KO) mice and to evaluate the tissue levels of striatal monoamines. Fmr1 KO mice were evaluated in the open field, marble burying and three-chamber test for the presence of hyperactivity, anxiety, repetitive behaviour, sociability and observation of social novelty compared with wild-type (WT) mice. The Fmr1 KO mice expressed anxiety and hyperactivity in the open field compared with WT mice. This increased level of hyperactivity was confirmed in the three-chamber test. Fmr1 KO mice spent more time with stranger mice compared with the WT. However, after a correction for hyperactivity, their apparent increase in sociability became identical to that of the WT. Furthermore, the Fmr1 KO mice could not differentiate between a familiar or a novel mouse. Monoamines were measured by HPLC: Fmr1 KO mice showed an increase in the striatal dopamine level. We conclude that the fragile X syndrome model seems to be useful for understanding certain aspects of ASD and may have translational interest for studies of social behaviour when hyperactivity coexists in ASD patients.

Phenobarbital use and neurological problems in FMR1 premutation carriers.

Science.gov (United States)

Saldarriaga, Wilmar; Lein, Pamela; González Teshima, Laura Yuriko; Isaza, Carolina; Rosa, Lina; Polyak, Andrew; Hagerman, Randi; Girirajan, Santhosh; Silva, Marisol; Tassone, Flora

2016-03-01

Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by a CGG expansion in the FMR1 gene located at Xq27.3. Patients with the premutation in FMR1 present specific clinical problems associated with the number of CGG repeats (55-200 CGG repeats). Premutation carriers have elevated FMR1 mRNA expression levels, which have been associated with neurotoxicity potentially causing neurodevelopmental problems or neurological problems associated with aging. However, cognitive impairments or neurological problems may also be related to increased vulnerability of premutation carriers to neurotoxicants, including phenobarbital. Here we present a study of three sisters with the premutation who were exposed differentially to phenobarbital therapy throughout their lives, allowing us to compare the neurological effects of this drug in these patients. Copyright © 2016 Elsevier Inc. All rights reserved.

Modelamiento de Fluidos Magnetoreológicos (FMR Producidos con Magnetita Mineral

Directory of Open Access Journals (Sweden)

Claudia Molina

2015-07-01

Full Text Available Esta investigación establece la correlación entre los resultados del cambio de densidad de un FMR, expuesto a un campo magnético de intensidad variable, con los resultados de la simulación del sistema por elementos finitos, en ANSYS. A nivel de laboratorio se prepararon doce muestras de FMR, con: magnetita mineral como material magnético molida a 325, 400 y 500 mallas; aceites 20W30 y 20W50 como fluidos de transporte y, aditivos antigravitacionales y antiaglomerantes. Con el FMR de mayor estabilidad fisicoquímica (baja reactividad y sedimentación, se realizaron pruebas de variación de la densidad, en función de la intensidad de un campo magnético. La correlación de los resultados de las pruebas de laboratorio con los resultados de la simulación, fue de 0.92, lo cual indica que la predicción del comportamiento de la densidad del FMR, en presencia de un campo magnético de intensidad variable, es un procedimiento confiable.

CoCr/NiFe double layers studied by FMR and VSM

NARCIS (Netherlands)

Stam, M.T.H.C.W.; Gerritsma, G.J.; Lodder, J.C.; Popma, T.J.A.

1987-01-01

CoCr/NiFe double layers were investigated by FMR and VSM. The FMR linewidth of NiFe of the double layer is about twice that of a single NiFe layer. The resonance field is the same in both cases. Using the VSM the coercive field of the CoCr layer of the double layer was obtained. It is approximately

FMR1 Knockout mice: A model to study fragile X mental retardation

Energy Technology Data Exchange (ETDEWEB)

Oostra, B.A.; Bakker, C.E.; Reyniers, E. [Erasmus Univ., Rotterdam (Netherlands)] [and others

1994-09-01

The fragile X syndrome is the most frequent form of inherited mental retardation in humans with an incidence of 1 in 1250 males and 1 in 2500 females. The clinical syndrome includes moderate to severe mental retardation, autistic behavior, macroorchidism, and facial features, such as long face with mandibular prognathism and large, everted ears. The molecular basis for this disease is a large expansion of a triplet repeat (CGG){sub n} in the 5{prime} untranslated region of the FMR1 gene. Due to this large expansion of the CGG repeat, the promoter region becomes methylated and the FMR1 gene is subsequently silenced. Hardly anything is known about the physiologic function of FMR1 and the pathologic mechanisms leading to these symptoms. Since the FMR1 gene is highly conserved in the mouse, we used the mouse to design a knockout model for the fragile X syndrome. These knockout mice lacking Fmrp have normal litter size suggesting that FMR1 is not essential in human gametogenesis and embryonic development. The knockout mice show the abnormalities also seen in the affected organs of human patients. Mutant mice show a gradual development through time of macroorchidism. In the knockout mice we observed cognitive defects in the form of deficits in learning (as shown by the hidden platform Morris water maze task) and behavioral abnormalities such as increased exploratory behavior and hyperactivity. Therefore this knockout mouse may serve as a valuable tool in studying the role of FMR1 in the fragile X syndrome and may serve as a model to elucidate the mechanisms involved in macroorchidism, abnormal behavior, and mental retardation.

Array-based FMR1 sequencing and deletion analysis in patients with a fragile X syndrome-like phenotype.

Directory of Open Access Journals (Sweden)

Stephen C Collins

2010-03-01

Full Text Available Fragile X syndrome (FXS is caused by loss of function mutations in the FMR1 gene. Trinucleotide CGG-repeat expansions, resulting in FMR1 gene silencing, are the most common mutations observed at this locus. Even though the repeat expansion mutation is a functional null mutation, few conventional mutations have been identified at this locus, largely due to the clinical laboratory focus on the repeat tract.To more thoroughly evaluate the frequency of conventional mutations in FXS-like patients, we used an array-based method to sequence FMR1 in 51 unrelated males exhibiting several features characteristic of FXS but with normal CGG-repeat tracts of FMR1. One patient was identified with a deletion in FMR1, but none of the patients were found to have other conventional mutations.These data suggest that missense mutations in FMR1 are not a common cause of the FXS phenotype in patients who have normal-length CGG-repeat tracts. However, screening for small deletions of FMR1 may be of clinically utility.

Correlation of normal-range FMR1 repeat length or genotypes and reproductive parameters.

Science.gov (United States)

Maslow, Bat-Sheva L; Davis, Stephanie; Engmann, Lawrence; Nulsen, John C; Benadiva, Claudio A

2016-09-01

This study aims to ascertain whether the length of normal-ranged CGG repeats on the FMR1 gene correlates with abnormal reproductive parameters. We performed a retrospective, cross-sectional study of all FMR1 carrier screening performed as part of routine care at a large university-based fertility center from January 2011 to March 2014. Correlations were performed between normal-range FMR1 length and baseline serum anti-Müllerian hormone (AMH), cycle day 3 follicle stimulating hormone (FSH), ovarian volumes (OV), antral follicle counts (AFC), and incidence of diminished ovarian reserve (DOR), while controlling for the effect of age. Six hundred three FMR1 screening results were collected. One subject was found to be a pre-mutation carrier and was excluded from the study. Baseline serum AMH, cycle day 3 FSH, OV, and AFC data were collected for the 602 subjects with normal-ranged CGG repeats. No significant difference in median age was noted amongst any of the FMR1 repeat genotypes. No significant correlation or association was found between any allele length or genotype, with any of the reproductive parameters or with incidence of DOR at any age (p > 0.05). However, subjects who were less than 35 years old with low/low genotype were significantly more likely to have below average AMH levels compared to those with normal/normal genotype (RR 3.82; 95 % CI 1.38-10.56). This large study did not demonstrate any substantial association between normal-range FMR1 repeat lengths and reproductive parameters.

How the FMR1 gene became relevant to female fertility and reproductive medicine

Directory of Open Access Journals (Sweden)

Norbert eGleicher

2014-08-01

Full Text Available This manuscript describes the 6-year evolution of our center’s research into ovarian functions of the FMR1 gene, which led to the identification of a new normal CGGn range of 26-34. This new normal range, in turn, led to definitions of different alleles (haplotypes based on whether no, one or both alleles are within range. Specific alleles then were demonstrated to represent distinct ovarian aging patterns, suggesting an important FMR1 function in follicle recruitment and ovarian depletion of follicles. So called low alleles, characterized by CGGn34 alleles. Because low FMR1 alleles present in approximately 25% of all females, FMR1 testing at young ages may offer an opportunity for earlier diagnosis of OPOI than current practice allows. Earlier diagnosis of OPOI, in turn, would give young women the options of reassessing their reproductive schedules and/or pursue fertility preservation via oocyte cryopreservation when most effective.

FMR study of carbon nanotubes filled with Fe{sub 3}O{sub 4} nanoparticles

Energy Technology Data Exchange (ETDEWEB)

Kopyl, S., E-mail: svitlanakopyl@ua.pt [NRD-TEMA, Department of Mechanical Engineering, Aveiro Institute of Nanotechnology (AIN), University of Aveiro, Aveiro 3810-193 (Portugal); Timopheev, A.A., E-mail: andreyt@ua.pt [Physics Department and I3N, University of Aveiro, Aveiro 3810-193 (Portugal); Bystrov, V.S. [Department of Materials and Ceramic Engineering and CICECO, University of Aveiro, Aveiro 3810-193 (Portugal); Institute of Mathematical Problems of Biology RAS, 142290 Pushchino (Russian Federation); Bdikin, I. [NRD-TEMA, Department of Mechanical Engineering, Aveiro Institute of Nanotechnology (AIN), University of Aveiro, Aveiro 3810-193 (Portugal); Teixeira, B.M.S. [Physics Department and I3N, University of Aveiro, Aveiro 3810-193 (Portugal); Maevskij, E. [Institute of Theoretical and Experimental Biophysics RAS, 142290 Puschino (Russian Federation); Sobolev, N.A. [Physics Department and I3N, University of Aveiro, Aveiro 3810-193 (Portugal); Sousa, A.C.M. [NRD-TEMA, Department of Mechanical Engineering, Aveiro Institute of Nanotechnology (AIN), University of Aveiro, Aveiro 3810-193 (Portugal)

2014-05-01

Ordered arrays of carbon nanotubes were produced using a non-catalytic chemical vapour deposition. The multiwall nanotubes with an inner diameter of 120 nm were grown inside porous alumina templates and then filled with a magnetic colloid of 7.5 nm Fe{sub 3}O{sub 4} particles. X-ray diffraction, electron microscopy and ferromagnetic resonance (FMR) were used to characterize structural and magnetic properties of the grown samples. To estimate the filling factor from the angular dependence of the FMR resonance field, we have derived an effective demagnetization factor for our system using the formalism proposed by Skomsky and Dubowik. Angular dependence of the FMR line width allows one to conclude about the non-uniform filling, while temperature dependent measurements reflect typical features of a superparamagnetic resonance. - Highlights: • Synthesis of CNTs inside of alumina membrane and filling it with Fe{sub 3}O{sub 4} particles. • X-ray diffraction and electron microscopy study of the samples. • Magnetic properties of the samples studied by FMR. • Filling factor has been determined from the angular dependences of FMR. • Resulted magnetic CNTs are attractive for production of magnetic nanofluids.

Wild-type male offspring of fmr-1+/- mothers exhibit characteristics of the fragile X phenotype.

Science.gov (United States)

Zupan, Bojana; Toth, Miklos

2008-10-01

Fragile X syndrome is an X-linked disorder caused by the inactivation of the FMR-1 gene with symptoms ranging from impaired cognitive functions to seizures, anxiety, sensory abnormalities, and hyperactivity. Males are more severely affected than heterozygote (H) females, who, as carriers, have a 50% chance of transmitting the mutated allele in each pregnancy. fmr-1 knockout (KO) mice reproduce fragile X symptoms, including hyperactivity, seizures, and abnormal sensory processing. In contrast to the expectation that wild-type (WT) males born to H (fmr-1(+/-)) mothers (H>WT) are behaviorally normal and indistinguishable from WT males born to WT mothers (WT>WT); here, we show that H>WT offspring are more active than WT>WT offspring and that their hyperactivity is similar to male KO mice born to H or KO (fmr-1(-/-)) mothers (H>KO/KO>KO). H>WT mice, however, do not exhibit seizures or abnormal sensory processing. Consistent with their hyperactivity, the effect of the D2 agonist quinpirole is reduced in H>WT as well as in H>KO and KO>KO mice compared to WT>WT offspring, suggesting a diminished feedback inhibition of dopamine release. Our data indicate that some aspects of hyperactivity and associated dopaminergic changes in 'fragile X' mice are a maternal fmr-1 genotype rather than an offspring fmr-1 genotype effect.

Impacts of yttrium substitution on FMR line-width and magnetic properties of nickel spinel ferrites

Energy Technology Data Exchange (ETDEWEB)

Ishaque, M., E-mail: ishaqdgk1@gmail.com [Department of Physics, Bahauddin Zakariya University, Multan 60800 (Pakistan); Khan, Muhammad Azhar, E-mail: azhar.khan@iub.edu.pk [Department of Physics, The Islamia University of Bahawalpur, Bahawalpur 63100 (Pakistan); Ali, Irshad; Khan, Hasan M. [Department of Physics, Bahauddin Zakariya University, Multan 60800 (Pakistan); Iqbal, M. Asif [Department of Physics, Bahauddin Zakariya University, Multan 60800 (Pakistan); College of E & ME, National University of Science and Technology, Islamabad (Pakistan); Islam, M.U. [Department of Physics, Bahauddin Zakariya University, Multan 60800 (Pakistan); Warsi, Muhammad Farooq [Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100 (Pakistan)

2015-05-15

The influence of yttrium (Y) substitution on ferromagnetic resonance (FMR), initial permeability, and magnetic properties of NiFe{sub 2}O{sub 4} ferrites were investigated. It was observed that the FMR line-width decreases with yttrium contents for the substitution level 0≤×≤0.06. Beyond this, the FMR line-width increases with yttrium contents. The nominal composition NiY{sub 0.12}Fe{sub 1.88}O{sub 4} exhibited the smallest FMR line-width ~282 Oe. A significant change in FMR position of nickel–yttrium (Ni–Y) ferrites was observed and it found to exist between 4150 and 4600 Oe. The saturation magnetization was observed to decrease with the increase of yttrium contents and this was referred to the redistribution of cations on octahedral. The coercivity increased from 15 Oe to 59 Oe by increasing the yttrium concentration. The initial permeability decreased from 110 to 35 at 1 MHz by the incorporation of yttrium and this was attributed to the smaller grains which may obstruct the domain wall movement and impede the domain wall motion. The magnetic loss factors of substituted samples exhibit decreasing behavior in the frequency range 1 kHz to 10 MHz. The smaller FMR line-width and reduced magnetic loss factor of the investigated samples suggest the possible use of these materials in high frequency applications. - Highlights: • Influence of Y{sup 3+} substitution on the properties of nickel ferrites is investigated. • Very small FMR line-width (282 Oe) is exhibited by these substituted ferrites. • Fourfold increase in coercivity was observed for NiY{sub 0.24}Fe{sub 1.76}O{sub 4} ferrites.

Study of the Genetic Etiology of Primary Ovarian Insufficiency: FMR1 Gene

Directory of Open Access Journals (Sweden)

Maitane Barasoain

2016-12-01

Full Text Available Menopause is a period of women’s life characterized by the cessation of menses in a definitive way. The mean age for menopause is approximately 51 years. Primary ovarian insufficiency (POI refers to ovarian dysfunction defined as irregular menses and elevated gonadotrophin levels before or at the age of 40 years. The etiology of POI is unknown but several genes have been reported as being of significance. The fragile X mental retardation 1 gene (FMR1 is one of the most important genes associated with POI. The FMR1 gene contains a highly polymorphic CGG repeat in the 5′ untranslated region of exon 1. Four allelic forms have been defined with respect to CGG repeat length and instability during transmission. Normal (5–44 CGG alleles are usually transmitted from parent to offspring in a stable manner. The full mutation form consists of over 200 repeats, which induces hypermethylation of the FMR1 gene promoter and the subsequent silencing of the gene, associated with Fragile X Syndrome (FXS. Finally, FMR1 intermediate (45–54 CGG and premutation (55–200 CGG alleles have been principally associated with two phenotypes, fragile X tremor ataxia syndrome (FXTAS and fragile X primary ovarian insufficiency (FXPOI.

Fragile X mental retardation 1 (FMR1) intron 1 methylation in blood predicts verbal cognitive impairment in female carriers of expanded FMR1 alleles: evidence from a pilot study.

Science.gov (United States)

Godler, David E; Slater, Howard R; Bui, Quang M; Storey, Elsdon; Ono, Michele Y; Gehling, Freya; Inaba, Yoshimi; Francis, David; Hopper, John L; Kinsella, Glynda; Amor, David J; Hagerman, Randi J; Loesch, Danuta Z

2012-03-01

Cognitive status in females with mutations in the FMR1 (fragile X mental retardation 1) gene is highly variable. A biomarker would be of value for predicting which individuals were liable to develop cognitive impairment and could benefit from early intervention. A detailed analysis of CpG sites bridging exon 1 and intron 1 of FMR1, known as fragile X-related epigenetic element 2 (FREE2), suggests that a simple blood test could identify these individuals. Study participants included 74 control females (Wechsler intelligence quotient (IQ) tests. We used MALDI-TOF mass spectrometry to determine the methylation status of FREE2 CpG sites that best identified low-functioning (IQ 200 CGG repeats), compared the results with those for Southern blot FMR1 activation ratios, and related these assessments to the level of production of the FMR1 protein product in blood. A methylation analysis of intron 1 CpG sites 10-12 showed the highest diagnostic sensitivity (100%) and specificity (98%) of all the molecular measures tested for detecting females with a standardized verbal IQ of <70 among the study participants. In the group consisting of only FM females, methylation of these sites was significantly correlated with full-scale IQ, verbal IQ, and performance IQ. Several verbal subtest scores showed strong correlation with the methylation of these sites (P = 1.2 × 10(-5)) after adjustment for multiple measures. The data suggest that hypermethylation of the FMR1 intron 1 sites in blood is predictive of cognitive impairment in FM females, with implications for improved fragile X syndrome diagnostics in young children and screening of the newborn population.

Electric-field tunable spin diode FMR in patterned PMN-PT/NiFe structures

Energy Technology Data Exchange (ETDEWEB)

Ziętek, Slawomir, E-mail: zietek@agh.edu.pl; Skowroński, Witold; Stobiecki, Tomasz [AGH University of Science and Technology, Department of Electronics, Al. Mickiewicza 30, 30-059 Kraków (Poland); Ogrodnik, Piotr, E-mail: piotrogr@if.pw.edu.pl [AGH University of Science and Technology, Department of Electronics, Al. Mickiewicza 30, 30-059 Kraków (Poland); Faculty of Physics, Warsaw University of Technology, ul. Koszykowa 75, 00-662 Warszawa (Poland); Stobiecki, Feliks [Institute of Molecular Physics, Polish Academy of Sciences, ul. Smoluchowskiego 17, 60-179 Poznań (Poland); Dijken, Sebastiaan van [NanoSpin, Department of Applied Physics, Aalto University School of Science, P.O. Box 15100, FI-00076 Aalto (Finland); Barnaś, Józef [Faculty of Physics, Adam Mickiewicz University, ul. Umultowska 85, 61-614 Poznań (Poland); Institute of Molecular Physics, Polish Academy of Sciences, ul. Smoluchowskiego 17, 60-179 Poznań (Poland)

2016-08-15

Dynamic properties of NiFe thin films on PMN-PT piezoelectric substrate are investigated using the spin-diode method. Ferromagnetic resonance (FMR) spectra of microstrips with varying width are measured as a function of magnetic field and frequency. The FMR frequency is shown to depend on the electric field applied across the substrate, which induces strain in the NiFe layer. Electric field tunability of up to 100 MHz per 1 kV/cm is achieved. An analytical model based on total energy minimization and the Landau-Lifshitz-Gilbert equation, taking into account the magnetostriction effect, is used to explain the measured dynamics. Based on this model, conditions for optimal electric-field tunable spin diode FMR in patterned NiFe/PMN-PT structures are derived.

FMR1 gene expansion and scans without evidence of dopaminergic deficits in parkinsonism patients.

Science.gov (United States)

Hall, D A; Jennings, D; Seibyl, J; Tassone, F; Marek, K

2010-11-01

To determine if patients with parkinsonism and fragile X mental retardation 1 (FMR1) gene expansions have a striatal dopamine deficit similar to Parkinson disease (PD) patients. The authors studied three patients with parkinsonism carrying small expansions in the FMR1 gene (41-60 CGG) with [(123)I]β-CIT SPECT imaging. The patients responded to dopaminergic medications, but had preserved dopamine transporter density. These results suggest that parkinsonism associated with smaller FMR1 expansions may be related to mechanisms other than pre-synaptic dopaminergic changes and may represent a potential explanation for at least some parkinsonian cases with scans without evidence of dopaminergic deficits (SWEDD). Copyright © 2010 Elsevier Ltd. All rights reserved.

The history of magnetization process influence on FMR response of particle systems

International Nuclear Information System (INIS)

Dumitru, Ioan; Stancu, Alexandru

2007-01-01

In order to express the history of magnetization process dependence on ferromagnetic resonance (FMR) for a particle system we use a statistical model based on the Preisach model. The precedent magnetization processes define in Preisach plane a configuration of particle magnetization orientations. The particles are considered single domain and saturated and are modeled as Stoner-Wohlfarth particles. The FMR response of the system is computed by summarizing the individual dynamic susceptibility of the particles, keeping account of the initial directions of the particle magnetizations. The FMR spectra of the particle system is determined considering three initial magnetization states: the demagnetized state, the positive saturated state in which all the particles have the magnetization in the static field direction and the negative saturated state when all the particles have the magnetization in the opposite field direction. The static field dependence of the resonance frequency and linewidth are determined as functions of the initial magnetization states

Intragenic FMR1 disease-causing variants: a significant mutational mechanism leading to Fragile-X syndrome

Science.gov (United States)

Quartier, Angélique; Poquet, Hélène; Gilbert-Dussardier, Brigitte; Rossi, Massimiliano; Casteleyn, Anne-Sophie; Portes, Vincent des; Feger, Claire; Nourisson, Elsa; Kuentz, Paul; Redin, Claire; Thevenon, Julien; Mosca-Boidron, Anne-Laure; Callier, Patrick; Muller, Jean; Lesca, Gaetan; Huet, Frédéric; Geoffroy, Véronique; El Chehadeh, Salima; Jung, Matthieu; Trojak, Benoit; Le Gras, Stéphanie; Lehalle, Daphné; Jost, Bernard; Maury, Stéphanie; Masurel, Alice; Edery, Patrick; Thauvin-Robinet, Christel; Gérard, Bénédicte; Mandel, Jean-Louis; Faivre, Laurence; Piton, Amélie

2017-01-01

Fragile-X syndrome (FXS) is a frequent genetic form of intellectual disability (ID). The main recurrent mutagenic mechanism causing FXS is the expansion of a CGG repeat sequence in the 5′-UTR of the FMR1 gene, therefore, routinely tested in ID patients. We report here three FMR1 intragenic pathogenic variants not affecting this sequence, identified using high-throughput sequencing (HTS): a previously reported hemizygous deletion encompassing the last exon of FMR1, too small to be detected by array-CGH and inducing decreased expression of a truncated form of FMRP protein, in three brothers with ID (family 1) and two splice variants in boys with sporadic ID: a de novo variant c.990+1G>A (family 2) and a maternally inherited c.420-8A>G variant (family 3). After clinical reevaluation, the five patients presented features consistent with FXS (mean Hagerman's scores=15). We conducted a systematic review of all rare non-synonymous variants previously reported in FMR1 in ID patients and showed that six of them are convincing pathogenic variants. This study suggests that intragenic FMR1 variants, although much less frequent than CGG expansions, are a significant mutational mechanism leading to FXS and demonstrates the interest of HTS approaches to detect them in ID patients with a negative standard work-up. PMID:28176767

Nuclear Law Bulletin Index Nos. 1 to 99

International Nuclear Information System (INIS)

2017-01-01

This new edition of the Nuclear Law Bulletin Index covers the first 99 issues of the Nuclear Law Bulletin (NLB). By established practice, the plan of the Index is not a replica of the Bulletin, as it was considered more useful for research purposes to group together all the information concerning legislative and regulatory activities, case law and bilateral agreements and to classify this information by country. Following classification by country, references to the work of international organisations, multilateral agreements, studies and articles are set out in separate sections. The 'Bibliography and News Briefs' section is omitted from the Index. A separate chapter of the Index has been devoted to the listing of the instruments published in the Supplements to the Bulletin, or in the Chapter 'Texts' from past Bulletins, up until the present date. Each item in the Index is followed by a reference to the relevant Bulletin. Legislative and regulatory texts, as well as agreements reproduced in the Bulletins or their Supplements, are also referenced. Plan of index: 1 - Reports and commentary 1a - Classification by country Legislative and regulatory activities (Environmental protection, Food irradiation, General legislation, regulations and instruments, International co-operation, Liability and compensation, Licensing and regulatory infrastructure, Nuclear installations, Nuclear safety and radiological protection - including nuclear emergency planning, Nuclear security, Nuclear trade - including non-proliferation, Nuclear-powered ships, Organisation and structure, Radioactive materials - including physical protection, Radioactive waste management, Transport of radioactive materials); Case law; Administrative decisions; Agreements; 1b - International organisations; 1c - Multilateral agreements; 2 - Studies and articles; 3 - Texts reproduced in the nuclear law bulletin; 3a - Classification by country; 3b - International organisations; 3c

Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.

Directory of Open Access Journals (Sweden)

Susanna Pietropaolo

Full Text Available BACKGROUND: No animal models of autism spectrum disorders (ASD with good construct validity are currently available; using genetic models of pathologies characterized by ASD-like deficits, but with known causes, may be therefore a promising strategy. The Fmr1-KO mouse is an example of this approach, modeling Fragile X syndrome, a well-known genetic disorder presenting ASD symptoms. The Fmr1-KO is available on different genetic backgrounds (FVB versus C57BL/6, which may explain some of the conflicting results that have been obtained with these mutants up till now. METHODS: Fmr1 KO and their wild-type littermates on both the FVB and C57BL/6 genetic backgrounds were examined on a battery of tests modeling the clinical symptoms of ASD, including the triad of core symptoms (alterations in social interaction and communication, presence of repetitive behaviors, as well as the secondary symptoms (disturbances in sensori-motor reactivity and in circadian patterns of activity, epileptic events. RESULTS: Fmr1-KO mice displayed autistic-like core symptoms of altered social interaction and occurrence of repetitive behaviors with additional hyperactivity. The genetic background modulated the effects of the Fmr1 deletion and it appears that the C57BL/6 background may be more suitable for further research on core autistic-like symptoms. CONCLUSIONS: The Fmr1-mouse line does not recapitulate all of the main core and secondary ASD symptoms, but still can be useful to elucidate the neurobiological mechanisms underlying specific ASD-like endophenotypes.

Environmental guidance regulatory bulletin

International Nuclear Information System (INIS)

1997-01-01

This document describes the background on expanding public participation in the Resource Conservation and Recovery Act and DOE's response. The bulletin also describes the changes made by the final rule to existing regulations, guidance provided by EPA in the preamble and in the revised RCRA Public Participation Manual, the relationship between public participation and environmental justice, and DOE's recent public participation and environmental justice initiatives

Activity Induces Fmr1-Sensitive Synaptic Capture of Anterograde Circulating Neuropeptide Vesicles.

Science.gov (United States)

Cavolo, Samantha L; Bulgari, Dinara; Deitcher, David L; Levitan, Edwin S

2016-11-16

Synaptic neuropeptide and neurotrophin stores are maintained by constitutive bidirectional capture of dense-core vesicles (DCVs) as they circulate in and out of the nerve terminal. Activity increases DCV capture to rapidly replenish synaptic neuropeptide stores following release. However, it is not known whether this is due to enhanced bidirectional capture. Here experiments at the Drosophila neuromuscular junction, where DCVs contain neuropeptides and a bone morphogenic protein, show that activity-dependent replenishment of synaptic neuropeptides following release is evident after inhibiting the retrograde transport with the dynactin disruptor mycalolide B or photobleaching DCVs entering a synaptic bouton by retrograde transport. In contrast, photobleaching anterograde transport vesicles entering a bouton inhibits neuropeptide replenishment after activity. Furthermore, tracking of individual DCVs moving through boutons shows that activity selectively increases capture of DCVs undergoing anterograde transport. Finally, upregulating fragile X mental retardation 1 protein (Fmr1, also called FMRP) acts independently of futsch/MAP-1B to abolish activity-dependent, but not constitutive, capture. Fmr1 also reduces presynaptic neuropeptide stores without affecting activity-independent delivery and evoked release. Therefore, presynaptic motoneuron neuropeptide storage is increased by a vesicle capture mechanism that is distinguished from constitutive bidirectional capture by activity dependence, anterograde selectivity, and Fmr1 sensitivity. These results show that activity recruits a separate mechanism than used at rest to stimulate additional synaptic capture of DCVs for future release of neuropeptides and neurotrophins. Synaptic release of neuropeptides and neurotrophins depends on presynaptic accumulation of dense-core vesicles (DCVs). At rest, DCVs are captured bidirectionally as they circulate through Drosophila motoneuron terminals by anterograde and retrograde

Publication of the bulletin

CERN Multimedia

2007-01-01

The final edition (Nos 51-52/2007 and 1-2-3/2008) of the last Bulletin of the year will appear on Friday 14 December and will cover events at CERN from 17 December 2007 to 18 January 2008. Announcements for publication in this issue should reach the Publication Section (Communication group) or the Staff Association, as appropriate, by noon on Tuesday 11 December. The table below lists the 2008 publication dates for the paper version of the Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12.00 midday on Tuesdays at the latest. Bulletin publication 2008 Bulletin N° 4-5 Publication: Monday 21 january Submission deadline for announcements: Tuesday 15 January Bulletin N° 6-7 Publication: Monday 4 february Submission deadline for announcements: Tuesday 29 January Bulletin N° 8-9 Publication: Monday 18 february Submission deadline for announcements: Tuesday 12 February Bulletin N° 10-11 P...

The Bulletin turns 50!

CERN Document Server

2015-01-01

What does the Bulletin mean to you? Send us your thoughts!   Fifty years ago, on 30 March 1965, the CERN Bulletin – or the Weekly Bulletin as it was known in those days – was born. It was just a simple newsletter back then, but the Bulletin has changed over the years to become a proper magazine bringing together articles on scientific and technical subjects as well as the latest news from the Laboratory and its personnel. And so, over time, the CERN Bulletin has become - the editors would like to think – an icon of the Laboratory, to which the people of CERN are very attached. If you agree, please send us your comments! Whatever theme you want to highlight – reading habits, anecdotes, scientific discoveries – we’d like to hear what the Bulletin means to you. These messages will be published in our anniversary edition on 27 March. The CERN Bulletin team

Age-Dependent Long-Term Potentiation Deficits in the Prefrontal Cortex of the Fmr1 Knockout Mouse Model of Fragile X Syndrome.

Science.gov (United States)

Martin, Henry G S; Lassalle, Olivier; Brown, Jonathan T; Manzoni, Olivier J

2016-05-01

The most common inherited monogenetic cause of intellectual disability is Fragile X syndrome (FXS). The clinical symptoms of FXS evolve with age during adulthood; however, neurophysiological data exploring this phenomenon are limited. The Fmr1 knockout (Fmr1KO) mouse models FXS, but studies in these mice of prefrontal cortex (PFC) function are underrepresented, and aging linked data are absent. We studied synaptic physiology and activity-dependent synaptic plasticity in the medial PFC of Fmr1KO mice from 2 to 12 months. In young adult Fmr1KO mice, NMDA receptor (NMDAR)-mediated long-term potentiation (LTP) is intact; however, in 12-month-old mice this LTP is impaired. In parallel, there was an increase in the AMPAR/NMDAR ratio and a concomitant decrease of synaptic NMDAR currents in 12-month-old Fmr1KO mice. We found that acute pharmacological blockade of mGlu5 receptor in 12-month-old Fmr1KO mice restored a normal AMPAR/NMDAR ratio and LTP. Taken together, the data reveal an age-dependent deficit in LTP in Fmr1KO mice, which may correlate to some of the complex age-related deficits in FXS. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Deletion of Fmr1 results in sex-specific changes in behavior.

Science.gov (United States)

Nolan, Suzanne O; Reynolds, Conner D; Smith, Gregory D; Holley, Andrew J; Escobar, Brianna; Chandler, Matthew A; Volquardsen, Megan; Jefferson, Taylor; Pandian, Ashvini; Smith, Tileena; Huebschman, Jessica; Lugo, Joaquin N

2017-10-01

In this study, we used a systemic Fmr1 knockout in order to investigate both genotype- and sex-specific differences across multiple measures of sociability, repetitive behaviors, activity levels, anxiety, and fear-related learning and memory. Fragile X syndrome is the most common monogenic cause of intellectual disability and autism. Few studies to date have examined sex differences in a mouse model of Fragile X syndrome, though clinical data support the idea of differences in both overall prevalence and phenotype between the sexes. Using wild-type and systemic homozygous Fmr1 knockout mice, we assessed a variety of behavioral paradigms in adult animals, including the open field test, elevated plus maze, nose-poke assay, accelerating rotarod, social partition task, three-chambered social task, and two different fear conditioning paradigms. Tests were ordered such that the most invasive tests were performed last in the sequence, and testing paradigms for similar behaviors were performed in separate cohorts to minimize testing effects. Our results indicate several sex-specific changes in Fmr1 knockout mice, including male-specific increases in activity levels, and female-specific increases in repetitive behaviors on both the nose-poke assay and motor coordination on the accelerating rotarod task. The results also indicated that Fmr1 deletion results in deficits in fear learning and memory across both sexes, and no changes in social behavior across two tasks. These findings highlight the importance of including female subjects in preclinical studies, as simply studying the impact of genetic mutations in males does not yield a complete picture of the phenotype. Further research should explore these marked phenotypic differences among the sexes. Moreover, given that treatment strategies are typically equivalent between the sexes, the results highlight a potential need for sex-specific therapeutics.

Publication of the Bulletin

CERN Multimedia

The final edition (Nos 51-52/2009 and 1-2/2010) of the last Weekly Bulletin of the year will be published on Friday 11 December and will cover events at CERN from 14 December 2009 to 8 January 2010. Announcements for publication in this issue should reach the Publication Section (Communications group) or the Staff Association, as appropriate, by noon on Tuesday 8 December. Bulletin publication 2010 The table below lists the 2010 publication dates for the paper version of the Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12.00 midday on Tuesdays at the latest. Bulletin No. Week number Submission of announcements (before 12.00 midday) Bulletin Web version Bulletin Paper version 2-3 Tuesday 5 January Friday 8 and 15 January Wednesday 13 J...

Array-based FMR1 sequencing and deletion analysis in patients with a fragile X syndrome-like phenotype

NARCIS (Netherlands)

S.C. Collins (Stephen); B. Coffee (Brad); P.J. Benke (Paul); E.M. Berry-Kravis (Elizabeth); F. Gilbert (Fred); B.A. Oostra (Ben); D. Halley (Dicky); M.E. Zwick (Michael); D.J. Cutler (David); S.T. Warren (Stephen)

2010-01-01

textabstractBackground: Fragile X syndrome (FXS) is caused by loss of function mutations in the FMR1 gene. Trinucleotide CGG-repeat expansions, resulting in FMR1 gene silencing, are the most common mutations observed at this locus. Even though the repeat expansion mutation is a functional null

Social Security Bulletin

Data.gov (United States)

Social Security Administration — The Social Security Bulletin (ISSN 1937-4666) is published quarterly by the Social Security Administration. The Bulletin is prepared in the Office of Retirement and...

SCIENTIFIC AND PRACTICAL ASPECTS OF THE BULLETINS DEVELOPMENT FOR CIVIL AIRCRAFT

Directory of Open Access Journals (Sweden)

Andrey N. Petrov

2017-01-01

Full Text Available The paper outlines science and methodological aspects of issuing bulletins for the civil aircraft and practical prob- lems accumulated in the national aviation industry within the mentioned area. Bulletins are used to inform operators about the purpose, data content and technologies outlining the design changes accomplishment if the aircraft considered at the moment of the design changes is already at the operational stage. Hence maintaining aircraft airworthiness is impossible without making certain modifications and repairs in the design, the bulletins issuing and implementation procedures have notable impact on safety and effectiveness of air transportation.Deficiencies considered are the results of practices used since 1980 and supported by the later interstate standard GOST 31270-2004 in the field of the bulletins development and implementation, which are not in line with contemporary conditions of international civil aviation activities. Negative consequences of transferring the Soviet way of working with aircraft bulletins intothe changed conditions of the state regulation of civil aviation activities in Russia are shown as well as those for substantial com-plication of the rules and procedures in comparison to the standards of Unified System of Design Documentation.Main theses of the ICAO standards and international practice are briefly analyzed, however they are not complete- ly presented in the national aviation regulations. The recommendations proposed are aimed to eliminate mentioned defi- ciencies through the standards amendment process and improvement of Russia's civil aviation regulatory base. Developed recommendations are mainly focused on the formulation of the new concept and certain content of the revised standard requirements to replace GOST 31270-2004.

Safety Bulletin 2014-2

CERN Multimedia

HSE Unit

2014-01-01

The HSE Unit would like to inform you that the Safety Bulletin 2014-2 entitled “False floors: real dangers” has just been released.     The Bulletin is available on EDMS under the following number: 1366385. We would like to remind you that HSE Safety Bulletins are published in English and French and incorporate feedback from incidents/near misses/accidents that have occurred on the CERN site, with the aim of improving prevention. We remain at your disposal in case you have further questions: safety.bulletin@cern.ch.

29 CFR 2509.94-3 - Interpretive bulletin relating to in-kind contributions to employee benefit plans.

Science.gov (United States)

2010-07-01

... employee benefit plans. 2509.94-3 Section 2509.94-3 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR GENERAL INTERPRETIVE BULLETINS RELATING TO...-kind contributions to employee benefit plans. (a) General. This bulletin sets forth the views of the...

Bulletin Survey - Early Results

CERN Multimedia

2002-01-01

There was a good response to our questionnaire on the Bulletin (around 450 so far). Many thanks to all of you - your views are invaluable to us. Pending publication of the full figures, which will give latecomers time to take part in the survey, here we give here answers some of your most frequent comments. Thank you for the many warm tributes and messages of encouragement we received. We also received criticisms about the way information is handled in the Bulletin and on its circulation. In today's issue we reply to these two points. Why is the Bulletin politically correct ? Many respondents reproach the Bulletin for a lack of objectivity and for being too politically correct to the point of being a propaganda organ. It is true that the Bulletin is not a newspaper, but rather a bulletin of communication (like SLAC's Beam Line). What is the difference ? A newspaper is objectively independent of the subjects it reports on, and when its reporters write stories they dig around for information from all parties...

Bulletin Survey: Technical clarifications

CERN Multimedia

2002-01-01

In the latest of our articles on the results of the Bulletin survey, we respond to some of your technical comments on the Electronic Bulletin. Many thanks to the more than 500 of you who completed the questionnaire. The full statistics will be published next week. 'It takes too long to download the pages' Yes, it's true that the Electronic Bulletin's download time isn't perfect but it will improve when the Bulletin migrates to another, faster database. 'I find it very difficult to locate all the articles' Some people experience difficulty negotiating their way through the Bulletin once they have entered a specific section. The blue column on the left contains an 'In this issue' link taking you to the other sections. What's more, the whole of the paper Bulletin is available in the electronic version. As the latter is relatively new, however, it will take a bit of time to get used to browsing through it. Many of you say that it's still too early to form an opinion. 'Pull-down menus would be good, so that yo...

Object recognition impairment in Fmr1 knockout mice is reversed by amphetamine: involvement of dopamine in the medial prefrontal cortex.

Science.gov (United States)

Ventura, R; Pascucci, T; Catania, M V; Musumeci, S A; Puglisi-Allegra, S

2004-09-01

Fragile X syndrome is an X-linked form of mental retardation including, among others, symptoms such as stereotypic behaviour, hyperactivity, hyperarousal, and cognitive deficits. We hypothesized that hyperactivity and/or compromised attentional, cognitive functions may lead to impaired performance in cognitive tasks in Fmr1 knockout mice, the most widely used animal model of fragile X syndrome, and suggested that psychostimulant treatment may improve performance by acting on one or both components. Since hyperactivity and cognitive functions have been suggested to depend on striatal and prefrontal cortex dopaminergic dysfunction, we assessed whether amphetamine produced beneficial, positive effects by acting on dopaminergic corticostriatal systems. Our results show that Fmr1 knockout mice are not able to discriminate between a familiar object and a novel one in the object recognition test, thus showing a clear-cut cognitive impairment that, to date, has been difficult to demonstrate in other cognitive tasks. Amphetamine improved performance of Fmr1 knockout mice, leading to enhanced ability to discriminate novel versus familiar objects, without significantly affecting locomotor activity. In agreement with behavioural data, amphetamine produced a greater increase in dopamine release in the prefrontal cortex of Fmr1 knockout compared with the wild-type mice, while a weak striatal dopaminergic response was observed in Fmr1 knockout mice. Our data support the view that the psychostimulant ameliorates performance in Fmr1 knockout mice by improving merely cognitive functions through its action on prefrontal cortical dopamine, irrespective of its action on motor hyperactivity. These results indicate that prefrontal cortical dopamine plays a major role in cognitive impairments characterizing Fmr1 knockout mice, thus pointing to an important aetiological factor in the fragile X syndrome.

Safety Bulletin 2013-3

CERN Multimedia

HSE Unit

2013-01-01

The HSE Unit just released the Safety Bulletin 2013-3 entitled “Drive with caution!”.   The Bulletin is available on EDMS under the following number: 1325442. Be reminded  that HSE Safety Bulletins are published in English and French and share feedbacks of incidents/nearmiss/accidents that happened on the CERN site with the aim to improve prevention.

Safety Bulletin 2013-1

CERN Multimedia

HSE Unit

2013-01-01

The HSE Unit has just released the Safety Bulletin 2013-1 entitled “When the alarm rings, you must leave!”.   The Bulletin is available on EDMS under the following number: 1307611. Be reminded  that HSE Safety Bulletins are published in English and French and share feedback on incidents/nearmiss/accidents on the CERN site with the aim of improving prevention.

Bulletin timetable for 2010

CERN Multimedia

CERN Bulletin

2009-01-01

The table below lists the 2010 publication dates for the paper version of the Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12.00 midday on Tuesdays at the latest. Bulletin No. Week number Submission of announcements (before 12.00 midday) Bulletin Web version Bulletin Paper version 2-3 Tuesday 5 January Friday 8 and 15 January Wednesday 13 January 4-5 Tuesday 19 January Friday 22 and 29 January Wednesday 27 January 6-7 Tuesday 2 February Friday 5 and 12 february Wednesday 10 February 8-9 Tuesday 16 February Friday 19 and 26 February ...

Chronic minocycline treatment improves social recognition memory in adult male Fmr1 knockout mice.

Science.gov (United States)

Yau, Suk Yu; Chiu, Christine; Vetrici, Mariana; Christie, Brian R

2016-10-01

Fragile X syndrome (FXS) is caused by a mutation in the Fmr1 gene that leads to silencing of the gene and a loss of its gene product, Fragile X mental retardation protein (FMRP). Some of the key behavioral phenotypes for FXS include abnormal social anxiety and sociability. Here we show that Fmr1 knock-out (KO) mice exhibit impaired social recognition when presented with a novel mouse, and they display normal social interactions in other sociability tests. Administering minocycline to Fmr1 KO mice throughout critical stages of neural development improved social recognition memory in the novel mouse recognition task. To determine if synaptic changes in the prefrontal cortex (PFC) could have played a role in this improvement, we examined PSD-95, a member of the membrane-associated guanylate kinase family, and signaling molecules (ERK1/2, and Akt) linked to synaptic plasticity in the PFC. Our analyses indicated that while minocycline treatment can enhance behavioral performance, it does not enhance expression of PSD-95, ERK1/2 or Akt in the PFC. Copyright © 2016 Elsevier B.V. All rights reserved.

Safety Bulletin 2013-4

CERN Multimedia

HSE Unit

2013-01-01

The HSE Unit has just released the Safety Bulletin 2013-4 entitled “Electrical work: protect yourself!”.   The Bulletin is available on EDMS under the following number: 1336918. We would like to remind you that HSE Safety Bulletins are published in English and French and share feedback from incidents/near misses/accidents that have occurred on the CERN site with the aim of improving prevention.

Safety Bulletin 2013-2

CERN Multimedia

HSE Unit

2013-01-01

The HSE Unit just released the Safety Bulletin 2013-2 entitled “Protect your head!”.   The Bulletin is available on EDMS under the following number: 1323573. We would like to remind you that HSE Safety Bulletins are published in English and French and share feedback from incidents/near misses/accidents that have occurred on the CERN site with the aim of improving prevention.

Wild-Type Male Offspring of fmr-1+/− Mothers Exhibit Characteristics of the Fragile X Phenotype

OpenAIRE

Zupan, Bojana; Toth, Miklos

2008-01-01

Fragile X syndrome is an X-linked disorder caused by the inactivation of the FMR-1 gene with symptoms ranging from impaired cognitive functions to seizures, anxiety, sensory abnormalities, and hyperactivity. Males are more severely affected than heterozygote (H) females, who, as carriers, have a 50% chance of transmitting the mutated allele in each pregnancy. fmr-1 knockout (KO) mice reproduce fragile X symptoms, including hyperactivity, seizures, and abnormal sensory processing. In contrast ...

β-glucuronidase use as a single internal control gene may confound analysis in FMR1 mRNA toxicity studies.

Science.gov (United States)

Kraan, Claudine M; Cornish, Kim M; Bui, Quang M; Li, Xin; Slater, Howard R; Godler, David E

2018-01-01

Relationships between Fragile X Mental Retardation 1 (FMR1) mRNA levels in blood and intragenic FMR1 CGG triplet expansions support the pathogenic role of RNA gain of function toxicity in premutation (PM: 55-199 CGGs) related disorders. Real-time PCR (RT-PCR) studies reporting these findings normalised FMR1 mRNA level to a single internal control gene called β-glucuronidase (GUS). This study evaluated FMR1 mRNA-CGG correlations in 33 PM and 33 age- and IQ-matched control females using three normalisation strategies in peripheral blood mononuclear cells (PBMCs): (i) GUS as a single internal control; (ii) the mean of GUS, Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) and succinate dehydrogenase complex flavoprotein subunit A (SDHA); and (iii) the mean of EIF4A2 and SDHA (with no contribution from GUS). GUS mRNA levels normalised to the mean of EIF4A2 and SDHA mRNA levels and EIF4A2/SDHA ratio were also evaluated. FMR1mRNA level normalised to the mean of EIF4A2 and SDHA mRNA levels, with no contribution from GUS, showed the most significant correlation with CGG size and the greatest difference between PM and control groups (p = 10-11). Only 15% of FMR1 mRNA PM results exceeded the maximum control value when normalised to GUS, compared with over 42% when normalised to the mean of EIF4A2 and SDHA mRNA levels. Neither GUS mRNA level normalised to the mean RNA levels of EIF4A2 and SDHA, nor to the EIF4A2/SDHA ratio were correlated with CGG size. However, greater variability in GUS mRNA levels were observed for both PM and control females across the full range of CGG repeat as compared to the EIF4A2/SDHA ratio. In conclusion, normalisation with multiple control genes, excluding GUS, can improve assessment of the biological significance of FMR1 mRNA-CGG size relationships.

Prenatal diagnosis of the fragile X syndrome : loss of mutation owing to a double recombinant or gene conversion event at the FMR1 locus

NARCIS (Netherlands)

Losekoot, M; Hoogendoorn, E; Olmer, R; Jansen, CCAM; Oosterwijk, JC; vandenOuweland, AMW; Halley, DJJ; Warren, ST; Willemsen, R; Oostra, BA; Bakker, E

1997-01-01

The fragile X syndrome, an X linked mental retardation syndrome, is caused by an expanded CGG repeat in the first exon of the FMR1 gene. In patients with an expanded repeat the FMR1 promoter is methylated and, consequently, the gene is silenced and no FMR1 protein (FMRP) is produced, thus leading to

Microdeletions including FMR1 in three female patients with intellectual disability - further delineation of the phenotype and expression studies

DEFF Research Database (Denmark)

Zink, A M; Wohlleber, E; Engels, H

2014-01-01

Fragile X syndrome (FXS) is one of the most common causes of intellectual disability/developmental delay (ID/DD), especially in males. It is caused most often by CGG trinucleotide repeat expansions, and less frequently by point mutations and partial or full deletions of the FMR1 gene. The wide...... clinical spectrum of affected females partly depends on their X-inactivation status. Only few female ID/DD patients with microdeletions including FMR1 have been reported. We describe 3 female patients with 3.5-, 4.2- and 9.2-Mb de novo microdeletions in Xq27.3-q28 containing FMR1. X-inactivation was random...

The effects of optimism, religion, and hope on mood and anxiety disorders in women with the FMR1 premutation.

Science.gov (United States)

Lowell, E P; Tonnsen, B L; Bailey, D B; Roberts, J E

2017-10-01

The FMR1 premutation, caused by a CGG trinucleotide repeat expansion on the FMR1 gene, has been identified as a genetic risk factor for mood and anxiety disorders. Building on recent studies identifying increased risk for mood and affective disorders in this population, we examined effects of potential protective factors (optimism, religion, hope) on depression and anxiety diagnoses in a prospective, longitudinal cohort. Eighty-three women with the FMR1 premutation participated in the Structured Clinical Interview for DSM-IV-TR Disorders at two-time points, 3 years apart. Participants also completed measures of optimism, religion, personal faith, hope, and child and family characteristics. We used logistic regression to examine correlates of major depressive disorder (MDD) and anxiety disorders at the initial assessment, as well as predictors of the diagnostic course over time. Lower optimism and higher religious participation relevant to fragile X syndrome at the initial assessment were associated with a lifetime history of MDD. Lower optimism also predicted the occurrence and reoccurrence of an anxiety disorder 3 years later. In women with the FMR1 premutation, elevated optimism may reduce the occurrence or severity of MDD and anxiety disorders. These findings underscore the importance of supporting mental health across the FMR1 spectrum of involvement. © 2017 MENCAP and International Association of the Scientific Study of Intellectual and Developmental Disabilities and John Wiley & Sons Ltd.

The magnetic-resonance properties study of nanostructures for spintronics by FMR

International Nuclear Information System (INIS)

Kupriyanova, G; Zyubin, A; Astashonok, A; Orlova, A; Prokhorenko, E

2011-01-01

In this work we report the study of the magnetic-resonance properties such as magnetic anisotropy, magnetic damping, and interlayer exchange coupling between ferromagnetic layers separated by a nonmagnetic spacer by FMR to assess their applicability in a functional magnetic tunnel junction.

The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

Directory of Open Access Journals (Sweden)

Tabolacci Elisabetta

2012-03-01

Full Text Available Abstract Background Fragile X syndrome (FXS, the leading cause of inherited mental retardation, is due to expansion and methylation of a CGG sequence in the FMR1 gene, which result in its silencing and consequent absence of FMRP protein. This absence causes loss of repression of metabotropic glutamate receptor 5 (mGluR5-mediated pathways resulting in the behavioral and cognitive impairments associated with FXS. In a randomized, double-blind trial it was recently demonstrated a beneficial effect of AFQ056, a selective inhibitor of metabotrobic glutamate receptor type 5 (mGluR5, on fully methylated FXS patients respect to partially methylated FXS ones. Methods To determine whether AFQ056 may have secondary effects on the methylation and transcription of FMR1, here we treated three FXS lymphoblastoid cell lines and one normal control male line. A quantitative RT-PCR was performed to assess transcriptional reactivation of the FMR1 gene. To assess the methylation status of the FMR1 gene promoter it was carried out a bisulphite sequencing analysis. Results Both FMR1-mRNA levels and DNA methylation were unmodified with respect to untreated controls. Conclusions These results demonstrate that the AFQ056 effect on fully methylated FXS patients is not due to a secondary effect on DNA methylation and consequent transcriptional activation of FMR1.

Inhibitors of Histone Deacetylases Are Weak Activators of the FMR1 Gene in Fragile X Syndrome Cell Lines

Directory of Open Access Journals (Sweden)

Alexander A. Dolskiy

2017-01-01

Full Text Available Fragile X syndrome is the most common cause of inherited intellectual disability in humans. It is a result of CGG repeat expansion in the 5′ untranslated region (5′ UTR of the FMR1 gene. This gene encodes the FMRP protein that is involved in neuronal development. Repeat expansion leads to heterochromatinization of the promoter, gene silencing, and the subsequent absence of FMRP. To date, there is no specific therapy for the syndrome. All treatments in clinic practice provide symptomatic therapy. The development of drug therapy for Fragile X syndrome treatment is connected with the search for inhibitors of enzymes that are responsible for heterochromatinization. Here, we report a weak transcriptional activity of the FMR1 gene and the absence of FMRP protein after Fragile X syndrome cell lines treatment with two FDA approved inhibitors of histone deacetylases, romidepsin and vorinostat. We demonstrate that romidepsin, an inhibitor of class I histone deacetylases, does not activate FMR1 expression in patient cell cultures, whereas vorinostat, an inhibitor of classes I and II histone deacetylases, activates a low level of FMR1 expression in some patient cell lines.

Endangered Species Protection Bulletins

Science.gov (United States)

Endangered Species Protection Bulletins set forth geographically specific pesticide use limitations for the protection of threatened and endangered (listed) species and their designated critical habitat. Find out how to get and use Bulletins.

Safety Bulletin 2014-1

CERN Multimedia

HSE Unit

2014-01-01

The HSE Unit would like to inform you that Safety Bulletin 2014-1 entitled “Call for help!” has just been released.   The Bulletin is available on EDMS under the following number: 1346313. We would like to remind you that HSE Safety Bulletins are published in English and French, and incorporate feedback from incidents/near misses/accidents that have occurred on the CERN site with the aim of improving prevention. We remain at your disposal in case you have further questions.

75 FR 51392 - Federal Management Regulation; Transportation Management

Science.gov (United States)

2010-08-20

...; Docket Number 2010-0011, sequence 1] RIN 3090-AJ03 Federal Management Regulation; Transportation Management AGENCY: Office of Governmentwide Policy, General Services Administration (GSA). ACTION: Final rule. SUMMARY: The General Services Administration (GSA) is amending the Federal Management Regulation (FMR) by...

OCRWM Bulletin

International Nuclear Information System (INIS)

1996-01-01

This document is the Winter 1996 ORCWM Bulletin which is a report from the U.S. Department of Energy's Office of Civilian Radioactive Waste Management. Budget considerations and a discussion of waste policy forums are described. Several articles about the on-going site characterization at Yucca Mountain are included as a part of this bulletin.Tunnel excavations, meteorology studies, effects of seismic events, and design of a conveyor belt system are some of the topics covered in this issue

Geomagnetic Indices Bulletin (GIB)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Geomagnetic Indices Bulletin is a one page sheet containing the magnetic indices Kp, Ap, Cp, An, As, Am and the provisional aa indices. The bulletin is published...

IDRC Bulletin #124

International Development Research Centre (IDRC) Digital Library (Canada)

2018-01-16

Jan 16, 2018 ... In this issue, read the research results from our Safe and Inclusive Cities program and don't forget that the Joint Canada-Israel Health Research Program 2018 call is now open. IDRC Bulletin logo IDRC Bulletin — Winter 2017. Featured this month. View of Port-au-Prince in Haiti, March 30, 2016. Safe and ...

Molecular analysis and test of linkage between the FMR-I gene and infantile autism in multiplex families

Energy Technology Data Exchange (ETDEWEB)

Hallmayer, J.; Pintado, E.; Lotspeich, L.; Spiker, D.; Kraemer, H.C.; Lee Wong, D.; Lin, A.; Herbert, J.; Cavalli-Sforza, L.L.; Ciaranello, R.D. [Stanford Univ., CA (United States)] [and others

1994-11-01

Approximately 2%-5% of autistic children show cytogenetic evidence of the fragile X syndrome. This report tests whether infantile autism in multiplex autism families arises from an unusual manifestion of the fragile X syndrome. This could arise either by expansion of the (CGG)n trinucleotide repeat in FMR-1 or from a mutation elsewhere in the gene. We studied 35 families that met stringent criteria for multiplex autism. Amplification of the trinucleotide repeat and analysis of methylation status were performed in 79 autistic children and in 31 of their unaffected siblings by Southern blot analysis. No examples of amplified repeats were seen in the autistic or control children or in their parents or grandparents. We next examined the hypothesis that there was a mutation elsewhere in the FMR-1 gene, by linkage analysis in 32 of these families. We tested four different dominant models and a recessive model. Linkage to FMR-1 could be excluded (lod score between -24 and -62) in all models by using probes DXS548, FRAXAC1, and FRAXAC2 and the CGG repeat itself. Tests for heterogeneity in this sample were negative, and the occurrence of positive lod scores in this data set could be attributed to chance. Analysis of the data by the affected-sib method also did not show evidence for linkage of any marker to autism. These results enable us to reject the hypothesis that multiplex autism arises from expansion of the (CGG)n trinucleotide repeat in FMR-1. Further, because the overall lod scores for all probes in all models tested were highly negative, linkage to FMR-1 can also be ruled out in multiplex autistic families. 35 refs., 2 figs., 5 tabs.

Repeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disorders

Science.gov (United States)

Usdin, Karen; Hayward, Bruce E.; Kumari, Daman; Lokanga, Rachel A.; Sciascia, Nicholas; Zhao, Xiao-Nan

2014-01-01

The Fragile X-related disorders are a group of genetic conditions that include the neurodegenerative disorder, Fragile X-associated tremor/ataxia syndrome (FXTAS), the fertility disorder, Fragile X-associated primary ovarian insufficiency (FXPOI) and the intellectual disability, Fragile X syndrome (FXS). The pathology in all these diseases is related to the number of CGG/CCG-repeats in the 5′ UTR of the Fragile X mental retardation 1 (FMR1) gene. The repeats are prone to continuous expansion and the increase in repeat number has paradoxical effects on gene expression increasing transcription on mid-sized alleles and decreasing it on longer ones. In some cases the repeats can simultaneously both increase FMR1 mRNA production and decrease the levels of the FMR1 gene product, Fragile X mental retardation 1 protein (FMRP). Since FXTAS and FXPOI result from the deleterious consequences of the expression of elevated levels of FMR1 mRNA and FXS is caused by an FMRP deficiency, the clinical picture is turning out to be more complex than once appreciated. Added complications result from the fact that increasing repeat numbers make the alleles somatically unstable. Thus many individuals have a complex mixture of different sized alleles in different cells. Furthermore, it has become apparent that the eponymous fragile site, once thought to be no more than a useful diagnostic criterion, may have clinical consequences for females who inherit chromosomes that express this site. This review will cover what is currently known about the mechanisms responsible for repeat instability, for the repeat-mediated epigenetic changes that affect expression of the FMR1 gene, and for chromosome fragility. It will also touch on what current and future options are for ameliorating some of these effects. PMID:25101111

OCRWM Bulletin

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-04-01

This document is the Winter 1996 ORCWM Bulletin which is a report from the U.S. Department of Energy`s Office of Civilian Radioactive Waste Management. Budget considerations and a discussion of waste policy forums are described. Several articles about the on-going site characterization at Yucca Mountain are included as a part of this bulletin.Tunnel excavations, meteorology studies, effects of seismic events, and design of a conveyor belt system are some of the topics covered in this issue.

Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.

Directory of Open Access Journals (Sweden)

Steven D Sheridan

Full Text Available Fragile X syndrome (FXS is the most common inherited cause of intellectual disability. In addition to cognitive deficits, FXS patients exhibit hyperactivity, attention deficits, social difficulties, anxiety, and other autistic-like behaviors. FXS is caused by an expanded CGG trinucleotide repeat in the 5' untranslated region of the Fragile X Mental Retardation (FMR1 gene leading to epigenetic silencing and loss of expression of the Fragile X Mental Retardation protein (FMRP. Despite the known relationship between FMR1 CGG repeat expansion and FMR1 silencing, the epigenetic modifications observed at the FMR1 locus, and the consequences of the loss of FMRP on human neurodevelopment and neuronal function remain poorly understood. To address these limitations, we report on the generation of induced pluripotent stem cell (iPSC lines from multiple patients with FXS and the characterization of their differentiation into post-mitotic neurons and glia. We show that clones from reprogrammed FXS patient fibroblast lines exhibit variation with respect to the predominant CGG-repeat length in the FMR1 gene. In two cases, iPSC clones contained predominant CGG-repeat lengths shorter than measured in corresponding input population of fibroblasts. In another instance, reprogramming a mosaic patient having both normal and pre-mutation length CGG repeats resulted in genetically matched iPSC clonal lines differing in FMR1 promoter CpG methylation and FMRP expression. Using this panel of patient-specific, FXS iPSC models, we demonstrate aberrant neuronal differentiation from FXS iPSCs that is directly correlated with epigenetic modification of the FMR1 gene and a loss of FMRP expression. Overall, these findings provide evidence for a key role for FMRP early in human neurodevelopment prior to synaptogenesis and have implications for modeling of FXS using iPSC technology. By revealing disease-associated cellular phenotypes in human neurons, these iPSC models will aid

Publication of the bulletin

CERN Document Server

DSU Unit

2008-01-01

The final edition (Nos 51-52/2008 and 1-2/2009) of the last Weekly Bulletin of the year will be published on Friday 12 December and will cover events at CERN from 15 December 2008 to 12 January 2009. Announcements for publication in this issue should reach the Publication Section (Communication group) or the Staff Association, as appropriate by noon, on Tuesday 9 December. Bulletin publication 2009 The table below lists the 2009 publication dates for the paper version of the Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12.00 midday on Tuesdays at the latest. Bulletin No. Week number Submission of announcements (before 12.00 midday) Publication date 3-4 Tuesday 6 January Monday 12 January 5-6 Tuesday 20 January Monday 26 January 7-8 Tuesday 3 February Monday 9 February 9-10 Tuesday 17 Februar...

Increased transient Na+ conductance and action potential output in layer 2/3 prefrontal cortex neurons of the fmr1-/y mouse.

Science.gov (United States)

Routh, Brandy N; Rathour, Rahul K; Baumgardner, Michael E; Kalmbach, Brian E; Johnston, Daniel; Brager, Darrin H

2017-07-01

Layer 2/3 neurons of the prefrontal cortex display higher gain of somatic excitability, responding with a higher number of action potentials for a given stimulus, in fmr1 -/y mice. In fmr1 -/y L2/3 neurons, action potentials are taller, faster and narrower. Outside-out patch clamp recordings revealed that the maximum Na + conductance density is higher in fmr1 -/y L2/3 neurons. Measurements of three biophysically distinct K + currents revealed a depolarizing shift in the activation of a rapidly inactivating (A-type) K + conductance. Realistic neuronal simulations of the biophysical observations recapitulated the elevated action potential and repetitive firing phenotype. Fragile X syndrome is the most common form of inherited mental impairment and autism. The prefrontal cortex is responsible for higher order cognitive processing, and prefrontal dysfunction is believed to underlie many of the cognitive and behavioural phenotypes associated with fragile X syndrome. We recently demonstrated that somatic and dendritic excitability of layer (L) 5 pyramidal neurons in the prefrontal cortex of the fmr1 -/y mouse is significantly altered due to changes in several voltage-gated ion channels. In addition to L5 pyramidal neurons, L2/3 pyramidal neurons play an important role in prefrontal circuitry, integrating inputs from both lower brain regions and the contralateral cortex. Using whole-cell current clamp recording, we found that L2/3 pyramidal neurons in prefrontal cortex of fmr1 -/y mouse fired more action potentials for a given stimulus compared with wild-type neurons. In addition, action potentials in fmr1 -/y neurons were significantly larger, faster and narrower. Voltage clamp of outside-out patches from L2/3 neurons revealed that the transient Na + current was significantly larger in fmr1 -/y neurons. Furthermore, the activation curve of somatic A-type K + current was depolarized. Realistic conductance-based simulations revealed that these biophysical changes in Na

Length of FMR1 repeat alleles within the normal range does not substantially affect the risk of early menopause

Science.gov (United States)

Ruth, Katherine S.; Bennett, Claire E.; Schoemaker, Minouk J.; Weedon, Michael N.; Swerdlow, Anthony J.; Murray, Anna

2016-01-01

STUDY QUESTION Is the length of FMR1 repeat alleles within the normal range associated with the risk of early menopause? SUMMARY ANSWER The length of repeat alleles within the normal range does not substantially affect risk of early menopause. WHAT IS KNOWN ALREADY There is a strong, well-established relationship between length of premutation FMR1 alleles and age at menopause, suggesting that this relationship could continue into the normal range. Within the normal range, there is conflicting evidence; differences in ovarian reserve have been identified with FMR1 repeat allele length, but a recent population-based study did not find any association with age at menopause as a quantitative trait. STUDY DESIGN, SIZE, DURATION We analysed cross-sectional baseline survey data collected at recruitment from 2004 to 2010 from a population-based, prospective epidemiological cohort study of >110 000 women to investigate whether repeat allele length was associated with early menopause. PARTICIPANTS/MATERIALS, SETTING, METHOD We included 4333 women from the Breakthrough Generations Study (BGS), of whom 2118 were early menopause cases (menopause under 46 years) and 2215 were controls. We analysed the relationship between length of FMR1 alleles and early menopause using logistic regression with allele length as continuous and categorical variables. We also conducted analyses with the outcome age at menopause as a quantitative trait as well as appropriate sensitivity and exploratory analyses. MAIN RESULTS AND THE ROLE OF CHANCE There was no association of the shorter or longer FMR1 allele or their combined genotype with the clinically relevant end point of early menopause in our main analysis. Likewise, there were no associations with age at menopause as a quantitative trait in our secondary analysis. LIMITATIONS, REASONS FOR CAUTION Women with homozygous alleles in the normal range may have undetected FMR1 premutation alleles, although there was no evidence to suggest this. We

New Bulletin: Latest News

CERN Multimedia

2005-01-01

The paper version of the CERN Bulletin will be published twice a month with effect from 18 April 2005. The electronic version will be updated weekly. This year will see many changes in the Bulletin, designed to make it more economical, more compact and more attractive.

76 FR 76622 - Federal Management Regulation; Motor Vehicle Management

Science.gov (United States)

2011-12-08

...; Docket 2011-0011; Sequence 2] RIN 3090-AJ14 Federal Management Regulation; Motor Vehicle Management... Administration is amending the Federal Management Regulation (FMR) by revising current policy on the definitions... CONTACT: For clarification of content, contact Mr. James Vogelsinger, Director, Motor Vehicle Management...

Characterization and validation of noninvasive oxygen tension measurements in human glioma xenografts by 19F-MR relaxometry

International Nuclear Information System (INIS)

Sanden, Boudewijn P.J. van der; Heerschap, Arend; Simonetti, Arjan W.; Rijken, Paul F.J.W.; Peters, Hans P.W.; Stbeen, Georg; Kogel, Albert J. van der

1999-01-01

Purpose: The aim of this study was to characterize and to validate noninvasive 19 F-magnetic resonance relaxometry for the measurement of oxygen tensions in human glioma xenografts in nude mice. The following three questions were addressed: 1. When perfluorocarbon compounds (PFCs) are administrated intravenously, which tumor regions are assessed by 19 F-MR relaxometry? 2. Are oxygen tension as detected by 19 F-MR relaxometry (pO 2/relaxo ) comparable to Eppendorf O 2 -electrode measurements (pO 2/electrode )? 3. Can 19 F-MR relaxometry be used to detect oxygen tension changes in tumor tissue during carbogen breathing? Methods and Materials: Slice-selective 19 F-MR relaxometry was carried out with perfluoro-15-crown-5-ether as oxygen sensor. The PFC was injected i.v. 3 days before the 19 F-MR experiments. Two datasets were acquired before and two after the start of carbogen breathing. The distribution of PFCs and necrotic areas were analyzed in 19 F-Spin Echo (SE) density MR images and T 2 -weighted 1 H-SE MR images, respectively. One day after the MR investigations, oxygen tensions were measured by oxygen electrodes in the same slice along two perpendicular tracks. These measurements were followed by (immuno)histochemical analysis of the 2D distribution of perfused microvessels, hypoxic cells, necrotic areas, and macrophages. Results: The PFCs mainly became sequestered in perfused regions at the tumor periphery; thus, 19 F-MR relaxometry probed mean oxygen tensions in these regions throughout the selected MR slice. In perfused regions of the tumor, mean pO 2/relaxo values were comparable to mean pO 2/electrode values, and varied from 0.03 to 9 mmHg. Median pO 2/electrode values of both tracks were lower than mean pO 2/relaxo values, because low pO 2/electrode values that originate from hypoxic and necrotic areas were also included in calculations of median pO 2/electrode values. After 8-min carbogen breathing, the average pO 2/relaxo increase was 3.3 ± 0.8 (SEM

The FMR1 gene and fragile X-associated tremor/ataxia syndrome

NARCIS (Netherlands)

J. Brouwer (Jaap); R.A. Willemsen (Ralph); B.A. Oostra (Ben)

2009-01-01

textabstractThe CGG-repeat present in the 5′UTR of the FMR1 gene is unstable upon transmission to the next generation. The repeat is up to 55 CGGs long in the normal population. In fragile X patients, a repeat length exceeding 200 CGGs (full mutation: FM) generally leads to methylation of the repeat

OCRWM Bulletin

International Nuclear Information System (INIS)

1995-01-01

This document is the Spring 1995 ORCWM Bulletin which is a report from the U.S. Department of Energy's Office of Civilian Radioactive Waste Management. Budget considerations, public response to waste acceptance issues, and a discussion of waste policy forums are described. Several articles about the on-going site characterization at Yucca Mountain are included as a part of this bulletin. Detection of pathways for gases and fluids in the subsurface, hydrochemistry experiments, and a description of the appointment of a new Yucca Mountain Site Characterization Office project manager are some of the topics covered in this issue

Certification of School Librarians: A Compilation of State Requirements, 1958. Bulletin, 1958, No. 12

Science.gov (United States)

Mahar, Mary Helen

1958-01-01

This bulletin on requirements by States and Territories for the certification of school librarians was prepared to provide a compilation of current certification regulations for school librarians and a summary of practices in formulating these regulations. The requirements for each State were obtained from either the State school library…

A 5 tesla superconducting magnet and cryostats for an EPR/FMR spectrometer

NARCIS (Netherlands)

Reuvekamp, E.M.C.M.; Gerritsma, G.J.; ten Kate, Herman H.J.; van de Klundert, L.J.M.

1988-01-01

A description is given of the cryogenic part of an electron paramagnetic resonance (EPR)/ferromagnetic resonance (FMR) spectrometer using Ka-band (26.5-40 GHz) and U-band (40-60 GHz) frequencies for resonance measurements on large magnetic thin-films. The unit has two cryostats; the first has a

New Bulletin: Latest News

CERN Multimedia

2005-01-01

The paper version of the CERN Bulletin will be published twice a month with effect from 18 April 2005. The electronic version will be updated weekly. This year will see many changes in the Bulletin, designed to make it more economical, more compact and more attractive. From 18 April the paper version of the Bulletin will be published twice monthly, so we shall have to stop calling it the "Weekly". The purpose of this change in publication frequency is to redistribute the resources of the Publications Section of the Communications Group so that it can produce new brochures for the general public. However, so as not to compromise on topicality and communication of information, the Official News and General Information sections, the Pension Fund and training announcements and the seminar schedule will continue to be updated weekly. If you have signed up to be informed of the updates, you will continue to receive a weekly e-mail reminding you that the electronic version of the Bulletin has been updated. Offici...

76 FR 31545 - Federal Management Regulation; Motor Vehicle Management

Science.gov (United States)

2011-06-01

...; Sequence 1] RIN 3090-AJ14 Federal Management Regulation; Motor Vehicle Management AGENCY: Office of... Services Administration is proposing to amend the Federal Management Regulation (FMR) by revising current....C. 553(a)(2) because it applies to agency management. However, this proposed rule is being published...

Getting in touch with the Bulletin team

CERN Multimedia

DSU Department

2008-01-01

The e-mail address for sending articles to the Bulletin has changed. To simplify the procedure, all articles and suggestions for articles (News, Official News, General Information) should be sent to the following address: Bulletin-Editors@cern.ch Thank you for your cooperation. The Bulletin team (DSU/CO-CC)

Fear-Specific Amygdala Function in Children and Adolescents on the Fragile X Spectrum: A Dosage Response of the FMR1 Gene

Science.gov (United States)

Kim, So-Yeon; Burris, Jessica; Bassal, Frederick; Koldewyn, Kami; Chattarji, Sumantra; Tassone, Flora; Hessl, David; Rivera, Susan M.

2014-01-01

Mutations of the fragile X mental retardation 1 (FMR1) gene are the genetic cause of fragile X syndrome (FXS). The presence of significant socioemotional problems has been well documented in FXS although the brain basis of those deficits remains unspecified. Here, we investigated amygdala dysfunction and its relation to socioemotional deficits and FMR1 gene expression in children and adolescents on the FX spectrum (i.e., individuals whose trinucleotide CGG repeat expansion from 55 to over 200 places them somewhere within the fragile X diagnostic range from premutation to full mutation). Participants performed an fMRI task in which they viewed fearful, happy, and scrambled faces. Neuroimaging results demonstrated that FX participants revealed significantly attenuated amygdala activation in Fearful > Scrambled and Fearful > Happy contrasts compared with their neurotypical counterparts, while showing no differences in amygdala volume. Furthermore, we found significant relationships between FMR1 gene expression, anxiety/social dysfunction scores, and reduced amygdala activation in the FX group. In conclusion, we report novel evidence regarding a dosage response of the FMR1 gene on fear-specific functions of the amygdala, which is associated with socioemotional deficits in FXS. PMID:23146966

Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

International Nuclear Information System (INIS)

Xu, Qin; Zhu, Zhiwei; Xu, Jialu; Gu, Weizhong; Zhao, Zhengyan

2012-01-01

Nitric oxide (NO), synthesized as needed by NO synthase (NOS), is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS). The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS) expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS) and male wild-type mice (WT) at postnatal day 7 (P7), P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7) and nNOS protein was estimated by Western blot (N = 3) and immunohistochemistry (N = 1). In the PCR assessment, primers 5′-GTGGCCATCGTGTCCTACCATAC-3′ and 5′-GTTTCGAGGCAGGTGGAAGCTA-3′ were used for the detection of nNOS and primers 5′-CCGTTTCTCCTGGCTCAGTTTA-3′ and 5′-CCCCAATACCACATCATCCAT-3′ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05). Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05). These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS

Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

Energy Technology Data Exchange (ETDEWEB)

Xu, Qin; Zhu, Zhiwei; Xu, Jialu [Department of Children' s Health Care, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China); Gu, Weizhong [Department of Pathology, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China); Zhao, Zhengyan [Department of Children' s Health Care, Children' s Hospital, Zhejiang University, Hangzhou Zhejiang (China)

2012-10-05

Nitric oxide (NO), synthesized as needed by NO synthase (NOS), is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS). The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS) expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS) and male wild-type mice (WT) at postnatal day 7 (P7), P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7) and nNOS protein was estimated by Western blot (N = 3) and immunohistochemistry (N = 1). In the PCR assessment, primers 5′-GTGGCCATCGTGTCCTACCATAC-3′ and 5′-GTTTCGAGGCAGGTGGAAGCTA-3′ were used for the detection of nNOS and primers 5′-CCGTTTCTCCTGGCTCAGTTTA-3′ and 5′-CCCCAATACCACATCATCCAT-3′ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05). Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05). These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS.

Depressed nNOS expression during spine transition in the developing hippocampus of FMR1 KO mice

Directory of Open Access Journals (Sweden)

Qin Xu

2012-12-01

Full Text Available Nitric oxide (NO, synthesized as needed by NO synthase (NOS, is involved in spinogenesis and synaptogenesis. Immature spine morphology is characteristic of fragile X syndrome (FXS. The objective of this research was to investigate and compare changes of postnatal neuronal NOS (nNOS expression in the hippocampus of male fragile X mental retardation 1 gene knockout mice (FMR1 KO mice, the animal model of FXS and male wild-type mice (WT at postnatal day 7 (P7, P14, P21, and P28. nNOS mRNA levels were analyzed by real-time quantitative PCR (N = 4-7 and nNOS protein was estimated by Western blot (N = 3 and immunohistochemistry (N = 1. In the PCR assessment, primers 5’-GTGGCCATCGTGTCCTACCATAC-3’ and 5’-GTTTCGAGGCAGGTGGAAGCTA-3’ were used for the detection of nNOS and primers 5’-CCGTTTCTCCTGGCTCAGTTTA-3’ and 5’-CCCCAATACCACATCATCCAT-3’ were used for the detection of β-actin. Compared to the WT group, nNOS mRNA expression was significantly decreased in FMR1 KO mice at P21 (KO: 0.2857 ± 0.0150, WT: 0.5646 ± 0.0657; P < 0.05. Consistently, nNOS immunoreactivity also revealed reduced staining intensity at P21 in the FMR1 KO group. Western blot analysis validated the immunostaining results by demonstrating a significant reduction in nNOS protein levels in the FMR1 KO group compared to the WT group at P21 (KO: 0.3015 ± 0.0897, WT: 1.7542 ± 0.5455; P < 0.05. These results suggest that nNOS was involved in the postnatal development of the hippocampus in FXS and impaired NO production may retard spine maturation in FXS.

The new Bulletin arrives in two weeks

CERN Multimedia

2006-01-01

In May, you will discover a redesigned CERN Bulletin. Starting with the first May issue (No. 19-20/2006), the format of the CERN Bulletin will change completely. The page layout will be more attractive, reminiscent of a proper newspaper, with pictograms to identify the different sections. The information provided will also be more visible. The Bulletin was much in need of a makeover as its current layout dates back to 1976! The introduction of the new format will coincide with the introduction of a new means of distribution. You will still receive the elctronic version of the Bulletin every week directly on your computer. However, in order to avoid the waste from the dozens of copies that linger unread in people's mailboxes, the paper version will be available at a series of distribution points around the Laboratory. You will find the Bulletin along with the Staff Association newsletter at the cafeteria closest to your office. The Bulletin will be available from the following distribution points: On the M...

The redesigned Bulletin is on its way

CERN Multimedia

2006-01-01

In May, you will discover a redesigned CERN Bulletin. Starting with the first May issue (No. 19-20/2006), the format of the Bulletin will change completely. The page layout will be more attractive, reminiscent of a proper newspaper, with pictograms to identify the different sections. The information provided will also be more visible. The Bulletin was much in need of a makeover as its current layout dates back to 1976! The introduction of the new format will coincide with the introduction of a new means of distribution. You will still receive the electronic version of the Bulletin every week directly on your computer. However, in order to avoid the waste from the dozens of copies that linger unread in people's mailboxes, the paper version will be available at a series of distribution points around the Laboratory. You will find the Bulletin along with the Staff Association newsletter at the cafeteria closest to your office. The Bulletin will be available from the following distribution points: On the Meyrin...

The fragile x mental retardation syndrome 20 years after the FMR1 gene discovery: an expanding universe of knowledge.

Science.gov (United States)

Rousseau, François; Labelle, Yves; Bussières, Johanne; Lindsay, Carmen

2011-08-01

The fragile X mental retardation (FXMR) syndrome is one of the most frequent causes of mental retardation. Affected individuals display a wide range of additional characteristic features including behavioural and physical phenotypes, and the extent to which individuals are affected is highly variable. For these reasons, elucidation of the pathophysiology of this disease has been an important challenge to the scientific community. 1991 marks the year of the discovery of both the FMR1 gene mutations involved in this disease, and of their dynamic nature. Although a mouse model for the disease has been available for 16 years and extensive research has been performed on the FMR1 protein (FMRP), we still understand little about how the disease develops, and no treatment has yet been shown to be effective. In this review, we summarise current knowledge on FXMR with an emphasis on the technical challenges of molecular diagnostics, on its prevalence and dynamics among populations, and on the potential of screening for FMR1 mutations.

The Fragile X Mental Retardation Syndrome 20 Years After the FMR1 Gene Discovery: an Expanding Universe of Knowledge

Science.gov (United States)

Rousseau, François; Labelle, Yves; Bussières, Johanne; Lindsay, Carmen

2011-01-01

The fragile X mental retardation (FXMR) syndrome is one of the most frequent causes of mental retardation. Affected individuals display a wide range of additional characteristic features including behavioural and physical phenotypes, and the extent to which individuals are affected is highly variable. For these reasons, elucidation of the pathophysiology of this disease has been an important challenge to the scientific community. 1991 marks the year of the discovery of both the FMR1 gene mutations involved in this disease, and of their dynamic nature. Although a mouse model for the disease has been available for 16 years and extensive research has been performed on the FMR1 protein (FMRP), we still understand little about how the disease develops, and no treatment has yet been shown to be effective. In this review, we summarise current knowledge on FXMR with an emphasis on the technical challenges of molecular diagnostics, on its prevalence and dynamics among populations, and on the potential of screening for FMR1 mutations. PMID:21912443

Repeat-mediated epigenetic dysregulation of the FMR1 gene in the fragile X-related disorders.

Science.gov (United States)

Usdin, Karen; Kumari, Daman

2015-01-01

The fragile X-related disorders are members of the Repeat Expansion Diseases, a group of genetic conditions resulting from an expansion in the size of a tandem repeat tract at a specific genetic locus. The repeat responsible for disease pathology in the fragile X-related disorders is CGG/CCG and the repeat tract is located in the 5' UTR of the FMR1 gene, whose protein product FMRP, is important for the proper translation of dendritic mRNAs in response to synaptic activation. There are two different pathological FMR1 allele classes that are distinguished only by the number of repeats. Premutation alleles have 55-200 repeats and confer risk of fragile X-associated tremor/ataxia syndrome and fragile X-associated primary ovarian insufficiency. Full mutation alleles on the other hand have >200 repeats and result in fragile X syndrome, a disorder that affects learning and behavior. Different symptoms are seen in carriers of premutation and full mutation alleles because the repeat number has paradoxical effects on gene expression: Epigenetic changes increase transcription from premutation alleles and decrease transcription from full mutation alleles. This review will cover what is currently known about the mechanisms responsible for these changes in FMR1 expression and how they may relate to other Repeat Expansion Diseases that also show repeat-mediated changes in gene expression.

29 CFR 785.24 - Principles noted in Portal-to-Portal Bulletin.

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Principles noted in Portal-to-Portal Bulletin. 785.24 Section 785.24 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... of Principles Preparatory and Concluding Activities § 785.24 Principles noted in Portal-to-Portal...

What you think about the Bulletin

CERN Multimedia

Alizée Dauvergne

2010-01-01

The internal communication service has carried out a survey regarding the quality of the Bulletin. Between the middle of May and the middle of June, 35 members of the CERN personnel were consulted individually about what they liked and disliked about the Bulletin and any changes they wanted to see.   A wide readership The first point to emerge from the survey is that the Bulletin is read by a large proportion of the CERN population, even if opinions on its form and contents vary: 33 of the 35 people questioned said that they read it, representing 94.3%. Some even consider it as a point of reference: "If a subject isn’t featured in the Bulletin, I don't even know it exists!", said one young woman. Different reading habits Of course, almost all the people questioned don't read the Bulletin from cover to cover but select the information which concerns them personally or is on a subject of interest to them. The choice of articles read varies according to profession, job a...

Pseudo-reorganization of language cortical function at fMR imaging: a consequence of tumor-induced neurovascular uncoupling.

Science.gov (United States)

Ulmer, John L; Krouwer, Hendrikus G; Mueller, Wade M; Ugurel, M Sahin; Kocak, Mehmet; Mark, Leighton P

2003-02-01

A left-handed patient with a grade II left frontal lobe astrocytoma had spontaneous seizures causing speech arrest and uncontrolled right upper extremity movements. Word-generation functional MR (fMR) imaging showed activity nearly exclusively in the right inferior frontal gyrus. The clinical history of the speech arrest and the intraoperative mapping proved left-hemisphere language dominance. Tumor involvement of the left inferior frontal gyrus caused uncoupling of the blood oxygenation level-dependent (BOLD) and neuronal response, leading to the erroneous fMR imaging appearance of right-hemisphere language dominance. Discrepancies between BOLD and intraoperative mapping in areas near lesions illustrate the complementary nature of these techniques.

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. M K Rabinal. Articles written in Bulletin of Materials Science. Volume 35 Issue 4 August 2012 pp 529-532. An optical tweezer-based study of antimicrobial activity of silver nanoparticles · Yogesha Sarbari Bhattacharya M K Rabinal Sharath Ananthamurthy · More Details Abstract ...

Hyperactivity and lack of social discrimination in the adolescent Fmr1 knockout mouse

DEFF Research Database (Denmark)

Sørensen, Emilie M; Bertelsen, Freja; Weikop, Pia

2015-01-01

. Monoamines were measured by HPLC: Fmr1 KO mice showed an increase in the striatal dopamine level. We conclude that the fragile X syndrome model seems to be useful for understanding certain aspects of ASD and may have translational interest for studies of social behaviour when hyperactivity coexists in ASD...

The Bulletin turns the page

CERN Multimedia

2006-01-01

Today, the paper version of the CERN Bulletin has a new look, the first since the 1970s. The new layout, which has been designed to improve readability, is part of an ongoing effort to improve internal communication at CERN. The Bulletin is the Organization's main tool for communication with the CERN community. It keeps everyone abreast of information that is important and essential for our working life at CERN. It plays an important role in keeping us up to date with social and scientific developments at the Laboratory. And it should be a force for cohesion across this very diverse organization. At the same time, the distribution for the printed Bulletin is being changed from individual mailboxes to distribution points around the Laboratory. This reflects changing reading habits, with the on-line version gaining a steadily increasing readership. For some time now, the paper Bulletin has been published fortnightly. However, the on-line version is updated weekly, so I encourage you all to look at it. In addi...

Discontinuation of the Bulletin's menu page

CERN Document Server

Publications Section

2005-01-01

The menus of the various CERN restaurants will no longer be published in the Bulletin as of Monday 4 April (issue No. 14/2005). The menu pages are being discontinued both as a savings measure and due to the low level of interest in this section of the Bulletin. The most recent survey of Bulletin readers showed that only 13% of the people questioned regularly read the menu section, compared to between 40% and 85% in the case of the other sections. Publications Section SG/CO Tel. 79971

Discontinuation of the Bulletin's menu page

CERN Multimedia

Publications Section

2005-01-01

The menus of the various CERN restaurants will no longer be published in the Bulletin as of Monday 4 April (issue No. 14/2005). The menu pages are being discontinued both as a savings measure and due to the low level of interest in this section of the Bulletin. The most recent survey of Bulletin readers showed that only 13% of the people questioned regularly read the menu section, compared to between 40% and 85% in the case of the other sections. Publications Section DSU-CO Tel. 79971

Fire and the Design of Educational Buildings. Building Bulletin 7. Sixth Edition.

Science.gov (United States)

Department of Education and Science, London (England).

This bulletin offers guidance on English school premises regulations applying to safety protection against fires in the following general areas: means of escape in case of fire; precautionary measures to prevent fire; fire warning systems and fire fighting; fire spreading speed; structures and materials resistant to fires; and damage control. It…

Delineation of the working memory profile in female FMR1 premutation carriers: the effect of cognitive load on ocular motor responses.

Science.gov (United States)

Shelton, Annie L; Cornish, Kim M; Godler, David E; Clough, Meaghan; Kraan, Claudine; Bui, Minh; Fielding, Joanne

2015-04-01

Fragile X mental retardation 1 (FMR1) premutation carriers (PM-carriers) are characterised as having mid-sized expansions of between 55 and 200 CGG repeats in the 5' untranslated region of the FMR1 gene. While there is evidence of executive dysfunction in PM-carriers, few studies have explicitly explored working memory capabilities in female PM-carriers. 14 female PM-carriers and 13 age- and IQ-matched healthy controls completed an ocular motor n-back working memory paradigm. This task examined working memory ability and the effect of measured increases in cognitive load. Female PM-carriers were found to have attenuated working memory capabilities. Increasing the cognitive load did not elicit the expected reciprocal increase in the task errors for female PM-carriers, as it did in controls. However female PM-carriers took longer to respond than controls, regardless of the cognitive load. Further, FMR1 mRNA levels were found to significantly predict PM-carrier response time. Although preliminary, these findings provide further evidence of executive dysfunction, specifically disruption to working memory processes, which were found to be associated with increases in FMR1 mRNA expression in female PM-carriers. With future validation, ocular motor paradigms such as the n-back paradigm will be critical to the development of behavioural biomarkers for identification of PM-carrier cognitive-affective phenotypes. Copyright © 2015 Elsevier B.V. All rights reserved.

OCRWM Bulletin, summer/fall 1994

International Nuclear Information System (INIS)

1994-01-01

This publication consists of two parts, OCRWM Bulletin, and Of Mountains ampersand Science which is about the Yucca Mountain project. The OCRWM bulletin provides information about OCRWM activities, program update to Congress, reorganization, training provided on OCRWM database, OCRWM calendar, and exhibit schedule for 1994. Recent work at the Yucca Mountain project such as the tunnel boring machines are presented in layman's term

Pragmatic Language Features of Mothers with the "FMR1" Premutation Are Associated with the Language Outcomes of Adolescents and Young Adults with Fragile X Syndrome

Science.gov (United States)

Klusek, Jessica; McGrath, Sara E.; Abbeduto, Leonard; Roberts, Jane E.

2016-01-01

Purpose: Pragmatic language difficulties have been documented as part of the FMR1 premutation phenotype, yet the interplay between these features in mothers and the language outcomes of their children with fragile X syndrome is unknown. This study aimed to determine whether pragmatic language difficulties in mothers with the "FMR1"…

Nuclear Knowledge Management e-Bulletin, April 2014

International Nuclear Information System (INIS)

2014-04-01

Since we issued our last e-Bulletin in January, we have held several very interesting and productive meetings with Member State representatives related to various initiatives in knowledge management, education and capacity building. We have highlighted some of them in this issue of our e-Bulletin. You will also notice the shorter format of this e-bulletin. This is in response to feedback from our readers, who have suggested we issue a more condensed e-bulletin, and issue it more often. As nuclear knowledge management is a relevant issue in most areas of the nuclear energy sector, the NKM Section is continually expanding cooperation with other departments and sections within the IAEA and you will see this reflected in our programme activities

CERN Bulletin publication schedule for 2014

CERN Multimedia

DG Unit

2013-01-01

The table below lists the 2014 publication dates for the CERN Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12.00 noon on Tuesdays at the latest.   Bulletin No. (corresponding to the week number) Submission of announcements (before 12.00 midday) Bulletin Web version Bulletin Printed version 4-5   Tuesday 14 January Friday 17 January Wednesday 22 January 6-7   Tuesday 28 January Friday 31 January Wednesday 5 February 8-9 Tuesday 11 February Friday 14 February Wednesday 19 February 10-11 Tuesday 25 February Friday 28 February Wednesday 5 March 12-13 Tuesday 11 March Friday 14 March Wednesday 19 March 14-15 Tuesday 25 March Friday 28 March Wednesday 2 April 16-17 Tuesday 8 April Friday 11 April Wednesday 16 April 18-19 Tuesday 22 April Friday 25 April Thursday 30 April 20-21 Tuesday 6 May Friday 9 May Wednesday 14 May 22-23 Tuesday ...

FMR1 CGG repeat expansion mutation detection and linked haplotype analysis for reliable and accurate preimplantation genetic diagnosis of fragile X syndrome.

Science.gov (United States)

Rajan-Babu, Indhu-Shree; Lian, Mulias; Cheah, Felicia S H; Chen, Min; Tan, Arnold S C; Prasath, Ethiraj B; Loh, Seong Feei; Chong, Samuel S

2017-07-19

Fragile X mental retardation 1 (FMR1) full-mutation expansion causes fragile X syndrome. Trans-generational fragile X syndrome transmission can be avoided by preimplantation genetic diagnosis (PGD). We describe a robust PGD strategy that can be applied to virtually any couple at risk of transmitting fragile X syndrome. This novel strategy utilises whole-genome amplification, followed by triplet-primed polymerase chain reaction (TP-PCR) for robust detection of expanded FMR1 alleles, in parallel with linked multi-marker haplotype analysis of 13 highly polymorphic microsatellite markers located within 1 Mb of the FMR1 CGG repeat, and the AMELX/Y dimorphism for gender identification. The assay was optimised and validated on single lymphoblasts isolated from fragile X reference cell lines, and applied to a simulated PGD case and a clinical in vitro fertilisation (IVF)-PGD case. In the simulated PGD case, definitive diagnosis of the expected results was achieved for all 'embryos'. In the clinical IVF-PGD case, delivery of a healthy baby girl was achieved after transfer of an expansion-negative blastocyst. FMR1 TP-PCR reliably detects presence of expansion mutations and obviates reliance on informative normal alleles for determining expansion status in female embryos. Together with multi-marker haplotyping and gender determination, misdiagnosis and diagnostic ambiguity due to allele dropout is minimised, and couple-specific assay customisation can be avoided.

The Meteoritical Bulletin, No. 103

Science.gov (United States)

Ruzicka, Alex; Grossman, Jeffrey; Bouvier, Audrey; Agee, Carl B.

2017-05-01

Meteoritical Bulletin 103 contains 2582 meteorites including 10 falls (Ardón, Demsa, Jinju, Križevci, Kuresoi, Novato, Tinajdad, Tirhert, Vicência, Wolcott), with 2174 ordinary chondrites, 130 HED achondrites, 113 carbonaceous chondrites, 41 ureilites, 27 lunar meteorites, 24 enstatite chondrites, 21 iron meteorites, 15 primitive achondrites, 11 mesosiderites, 10 Martian meteorites, 6 Rumuruti chondrites, 5 ungrouped achondrites, 2 enstatite achondrites, 1 relict meteorite, 1 pallasite, and 1 angrite, and with 1511 from Antarctica, 588 from Africa, 361 from Asia, 86 from South America, 28 from North America, and 6 from Europe. Note: 1 meteorite from Russia was counted as European. The complete contents of this bulletin (244 pages) are available on line. Information about approved meteorites can be obtained from the Meteoritical Bulletin Database (MBD) available on line at meteor/">http://www.lpi.usra.edu/meteor/.

CBP Quota Bulletins

Data.gov (United States)

Department of Homeland Security — Quota information is issued for the trade community by the Quota Enforcement Administration Branch within the Office of International Trade. The Quota Bulletins have...

Development of Genetic Testing for Fragile X Syndrome and Associated Disorders, and Estimates of the Prevalence of FMR1 Expansion Mutations

Directory of Open Access Journals (Sweden)

James N. Macpherson

2016-11-01

Full Text Available The identification of a trinucleotide (CGG expansion as the chief mechanism of mutation in Fragile X syndrome in 1991 heralded a new chapter in molecular diagnostic genetics and generated a new perspective on mutational mechanisms in human genetic disease, which rapidly became a central paradigm (“dynamic mutation” as more and more of the common hereditary neurodevelopmental disorders were ascribed to this novel class of mutation. The progressive expansion of a CGG repeat in the FMR1 gene from “premutation” to “full mutation” provided an explanation for the “Sherman paradox,” just as similar expansion mechanisms in other genes explained the phenomenon of “anticipation” in their pathogenesis. Later, FMR1 premutations were unexpectedly found associated with two other distinct phenotypes: primary ovarian insufficiency and tremor-ataxia syndrome. This review will provide a historical perspective on procedures for testing and reporting of Fragile X syndrome and associated disorders, and the population genetics of FMR1 expansions, including estimates of prevalence and the influence of AGG interspersions on the rate and probability of expansion.

Population-based estimates of the prevalence of FMR1 expansion mutations in women with early menopause and primary ovarian insufficiency.

Science.gov (United States)

Murray, Anna; Schoemaker, Minouk J; Bennett, Claire E; Ennis, Sarah; Macpherson, James N; Jones, Michael; Morris, Danielle H; Orr, Nick; Ashworth, Alan; Jacobs, Patricia A; Swerdlow, Anthony J

2014-01-01

Primary ovarian insufficiency before the age of 40 years affects 1% of the female population and is characterized by permanent cessation of menstruation. Genetic causes include FMR1 expansion mutations. Previous studies have estimated mutation prevalence in clinical referrals for primary ovarian insufficiency, but these are likely to be biased as compared with cases in the general population. The prevalence of FMR1 expansion mutations in early menopause (between the ages of 40 and 45 years) has not been published. We studied FMR1 CGG repeat number in more than 2,000 women from the Breakthrough Generations Study who underwent menopause before the age of 46 years. We determined the prevalence of premutation (55-200 CGG repeats) and intermediate (45-54 CGG repeats) alleles in women with primary ovarian insufficiency (n = 254) and early menopause (n = 1,881). The prevalence of the premutation was 2.0% in primary ovarian insufficiency, 0.7% in early menopause, and 0.4% in controls, corresponding to odds ratios of 5.4 (95% confidence interval = 1.7-17.4; P = 0.004) for primary ovarian insufficiency and 2.0 (95% confidence interval = 0.8-5.1; P = 0.12) for early menopause. Combining primary ovarian insufficiency and early menopause gave an odds ratio of 2.4 (95% confidence interval = 1.02-5.8; P = 0.04). Intermediate alleles were not significant risk factors for either early menopause or primary ovarian insufficiency. FMR1 premutations are not as prevalent in women with ovarian insufficiency as previous estimates have suggested, but they still represent a substantial cause of primary ovarian insufficiency and early menopause.

1991 OCRWM bulletin compilation and index

International Nuclear Information System (INIS)

1992-05-01

The OCRWM Bulletin is published by the Department of Energy, Office of Civilian Radioactive Waste Management, to provide current information about the national program for managing spent fuel and high-level radioactive waste. The document is a compilation of issues from the 1991 calendar year. A table of contents and an index have been provided to reference information contained in this year's Bulletins

29 CFR 2509.78-1 - Interpretive bulletin relating to payments by certain employee welfare benefit plans.

Science.gov (United States)

2010-07-01

... employee welfare benefit plans. 2509.78-1 Section 2509.78-1 Labor Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR GENERAL INTERPRETIVE BULLETINS RELATING TO... payments by certain employee welfare benefit plans. The Department of Labor today announced its...

A Special Extract of Bacopa monnieri (CDRI-08-Restored Memory in CoCl2-Hypoxia Mimetic Mice Is Associated with Upregulation of Fmr-1 Gene Expression in Hippocampus

Directory of Open Access Journals (Sweden)

Anupama Rani

2015-01-01

Full Text Available Fragile X mental retardation protein (FMRP is a neuronal translational repressor and has been implicated in learning, memory, and cognition. However, the role of Bacopa monnieri extract (CDRI-08 in enhancing cognitive abilities in hypoxia-induced memory impairment via Fmr-1 gene expression is not known. Here, we have studied effects of CDRI-08 on the expression of Fmr-1 gene in the hippocampus of well validated cobalt chloride (CoCl2-induced hypoxia mimetic mice and analyzed the data with alterations in spatial memory. Results obtained from Morris water maze test suggest that CoCl2 treatment causes severe loss of spatial memory and CDRI-08 is capable of reversing it towards that in the normal control mice. Our semiquantitative RT-PCR, Western blot, and immunofluorescence microscopic data reveal that CoCl2-induced hypoxia significantly upregulates the expression of Hif-1α and downregulates the Fmr-1 expression in the hippocampus, respectively. Further, CDRI-08 administration reverses the memory loss and this is correlated with significant downregulation of Hif-1α and upregulation of Fmr-1 expression. Our data are novel and may provide mechanisms of hypoxia-induced impairments in the spatial memory and action of CDRI-08 in the recovery of hypoxia led memory impairment involving Fmr-1 gene encoded protein called FMRP.

CAT-ASVAB Technical Bulletin Number 1

Science.gov (United States)

2006-03-01

CAT -ASVAB Technical Bulletin #1 Personnel Testing Division Defense Manpower Data Center March 2006 Report...2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE CAT -ASVAB Technical Bulletin #1 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...Hetter, R. D. "Psychometric Procedures for Administering CAT -ASVAB" (pp. 131-140) Chapter 4 Hetter, R. D., & Sympson J. B. "Item Exposure

Solar Indices Bulletin

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Solar Indices Bulletin is a prompt monthly information product that is distributed within two weeks after the observation month closes. For the month just ended,...

IDRC Bulletin #127

International Development Research Centre (IDRC) Digital Library (Canada)

Subscribe | Unsubscribe. Subscribe to IDRC's regional newsletters. Asia | Latin America and the Caribbean | Middle East and North Africa | Sub-Saharan Africa Questions or comments? Send us your feedback at bulletin@idrc.ca. Canada ...

Social anxiety and autism spectrum traits among adult FMR1 premutation carriers.

Science.gov (United States)

López-Mourelo, O; Mur, E; Madrigal, I; Alvarez-Mora, M I; Gómez-Ansón, B; Pagonabarraga, J; Rodriguez-Revenga, L; Milà, M

2017-01-01

Behavioral symptoms and traits have been proposed as early markers in neurodegenerative diseases. The aim of this study was to evaluate social anxiety and autism in FMR1 premutation carriers using the Social Phobia Inventory (SPIN) and the Autism-Spectrum Quotient (AQ) questionnaires. Fifty-nine premutation carriers were compared with 50 controls. The SPIN test showed statistically significant differences between female but not male carriers. The AQ questionnaire found statistically significant differences between premutation carriers and controls in the total AQ as well as in the social skills and attention switching subdomains. A gender effect was only observed for the social skills subdomain. Spearman's correlation analysis revealed a moderately positive correlation with the total AQ scores as well as the social skills and communication subdomains. Our results show that fragile X-associated tremor/ataxia syndrome (FXTAS) patients have higher AQ scores. Moreover, this is the first study to find statistically significant differences between FXTAS and no-FXTAS premutation carriers in the communication and the imagination subdomains, suggesting that FXTAS patients present a broader autistic phenotype than premutation carriers without FXTAS. Based on our results, a wide range of behavioral/psychiatric traits should be included within the broader phenotypic presentation of individuals with the FMR1 premutation. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Magnetic characterization by SQUID and FMR of a biocompatible ferrofluid based on Fe3O4

International Nuclear Information System (INIS)

Gamarra, L F; Amaro Jr, E; Pontuschka, W M; Mamani, J B; Cornejo, D R; Oliveira, T R; Vieira, E D; Costa-Filho, A J

2009-01-01

Biocompatible superparamagnetic iron oxide nanoparticles of magnetite coated with dextran were magnetically characterized using the techniques of SQUID (superconducting quantum interference device) magnetometry and ferromagnetic resonance (FMR). The SQUID magnetometry characterization was performed by isothermal measurements under applied magnetic field using the methods of zero-field-cooling (ZFC) and field-cooling (FC). The magnetic behavior of the nanoparticles indicated their superparamagnetic nature and it was assumed that they consisted exclusively of monodomains. The transition to a blocked state was observed at the temperature T B = (43 ± 1) K for frozen ferrofluid and at (52 ± 1) K for the lyophilized ferrofluid samples. The FMR analysis showed that the derivative peak-to-peak linewidth (ΔH PP ), gyromagnetic factor (g), number of spins (N S ), and spin-spin relaxation time (T 2 ) were strongly dependent on both temperature and super-exchange interaction. This information is important for possible nanotechnological applications, mainly those which are strongly dependent on the magnetic parameters.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. SARAVANA KUMAR JAGANATHAN. Articles written in Bulletin of Materials Science. Volume 41 Issue 1 February 2018 pp 18. Advanced nanofibrous textile-based dressing material for treating chronic wounds · ISABEL HERRMANN EKO SUPRIYANTO SARAVANA KUMAR ...

ICFA Instrumentation Bulletin, Volume 14, Spring 1997

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-07-01

The publication of the ICFA Instrumentation Bulletin is an activity of the Panel on Future Innovation and Development of ICFA (International Committee for Future Accelerators). The Bulletin reports on research and progress in the field of instrumentation with emphasis on application in the field of high-energy physics. It encourages issues of generic instrumentation.

29 CFR 2509.75-3 - Interpretive bulletin relating to investments by employee benefit plans in securities of...

Science.gov (United States)

2010-07-01

... Regulations Relating to Labor (Continued) EMPLOYEE BENEFITS SECURITY ADMINISTRATION, DEPARTMENT OF LABOR... Interpretive bulletin relating to investments by employee benefit plans in securities of registered investment.... That section provides that an investment by an employee benefit plan in securities issued by an...

bulletin Publication 2009

CERN Document Server

DSU Unit

2008-01-01

The table below lists the 2009 publication dates for the paper version of the Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12.00 midday on Tuesdays at the latest. Bulletin No. Week number Submission of announcements (before 12.00 midday) Publication date 3-4 Tuesday 6 January Monday 12 January 5-6 Tuesday 20 January Monday 26 January 7-8 Tuesday 3 February Monday 9 February 9-10 Tuesday 17 February Monday 23 February 11-12 Tuesday 3 March Monday 9 March 13-14 Tuesday 17 March Monday 23 March 15-16-17 (Easter issue) Tuesday 31 March Monday 6 April 18-19 Tuesday 21 April Monday 27 April 20-21 Tuesday 5 May Monday 11 May 22-23 Tuesday 19 May Monday 25 May 24-25 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K Bajpai. Articles written in Bulletin of Materials Science. Volume 28 Issue 6 October 2005 pp 529-534 Review—Polymers. Morphological, thermal and annealed microhardness characterization of gelatin based interpenetrating networks of polyacrylonitrile: A hard biopolymer.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. ISABEL HERRMANN. Articles written in Bulletin of Materials Science. Volume 41 Issue 1 February 2018 pp 18. Advanced nanofibrous textile-based dressing material for treating chronic wounds · ISABEL HERRMANN EKO SUPRIYANTO SARAVANA KUMAR JAGANATHAN A ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. REGINA C SO. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1179-1187. Preparation, characterization of chitosan/bamboo charcoal/poly(methacrylate) composite beads · DOROTHY CAMINOS-PERUELO WEI-CHIEH WANG ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. S Prasannakumar. Articles written in Bulletin of Materials Science. Volume 24 Issue 5 October 2001 pp 535-538 Polymers. Interpenetrating polymer networks based on polyol modified castor oil polyurethane and poly(2-hydroxyethylmethacrylate): Synthesis, chemical, ...

NEW EDITOR OF THE CMS BULLETIN

CERN Multimedia

Walter Van Doninck has been the Editor of the CMS Bulletin since 2000. The Bulletin not only helps disseminate information but also records the progress of CMS. Walter is handing over to Karl Gill. We would like to thank Walter for carrying out this task with enthusiasm and efficiency for so long. We should also thank Karl for accepting to take over and wish him well over the coming exciting period.

The fragile X syndrome: Isolation of the FMR-1 gene and characterization of the fragile X mutation

NARCIS (Netherlands)

B.A. Oostra (Ben); A. Verkerk

1992-01-01

markdownabstractConclusion Rapid progress has been made in the analysis of the fragile X syndrome during 1991. Different groups have discovered that fragile X chromosomes are preferentially methylated. In these X chromosomes an insertion has been found in the methylated region. The FMR-1 gene,

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. SURESH KUMAR. Articles written in Bulletin of Materials Science. Volume 35 Issue 5 October 2012 pp 787-794. Electrical transport and EPR investigations: A comparative study for d.c. conduction mechanism in monovalent and multivalent ions doped polyaniline.

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Neelotpal Sen Sarma. Articles written in Bulletin of Materials Science. Volume 37 Issue 7 December 2014 pp 1613-1624. Enhancement of proton conductivity of sulfonated polystyrene membrane prepared by plasma polymerization process · Bhabesh Kumar Nath Aziz Khan ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Nitai Debnath. Articles written in Bulletin of Materials Science. Volume 37 Issue 2 April 2014 pp 199-206. Ciprofloxacin conjugated zinc oxide nanoparticle: A camouflage towards multidrug resistant bacteria · Prasun Patra Shouvik Mitra Nitai Debnath Panchanan Pramanik ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Arunkumar Lagashetty. Articles written in Bulletin of Materials Science. Volume 27 Issue 6 December 2004 pp 491-495 Nanomaterials. Adsorption study of Pb ions on nanosized SnO2, synthesized by self-propagating combustion reaction · Arunkumar Lagashetty A ...

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Home; Journals; Bulletin of Materials Science. MURAT UYGUN. Articles written in Bulletin of Materials Science. Volume 39 Issue 2 April 2016 pp 353-359. Hydrophobic nano-carrier for lysozyme adsorption · CANAN ALTUNBAS FULDEN ZEYNEP URAL MURAT UYGUN NESIBE AVCIBASI UGUR AVCIBASI DENIZ AKTAS ...

THR Bulletin

African Journals Online (AJOL)

Yasin

factors and gender relations. This paper looks at the influence of the sex of a child on response to febrile illness. Materials and Methods. Study area. The study was carried out in Mbaise, Imo State,. Nigeria. Mbaise is one of the most culturally distinct rural communities in Imo State, with an. Tanzania Health Research Bulletin ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Sandeep Arya. Articles written in Bulletin of Materials Science. Volume 36 Issue 4 August 2013 pp 535-539. Synthesis of copper telluride nanowires using template-based electrodeposition method as chemical sensor · Sandeep Arya Saleem Khan Suresh Kumar Rajnikant ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Dinesh Kumar. Articles written in Bulletin of Materials Science. Volume 25 Issue 6 November 2002 pp 549-551. Semiconductor applications of plasma immersion ion implantation technology · Mukesh Kumar Rajkumar Dinesh Kumar P J George · More Details Abstract Fulltext ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. T Mirza. Articles written in Bulletin of Materials Science. Volume 23 Issue 5 October 2000 pp 377-382 Glass Ceramics. Preparation and characterization of magnesium–aluminium–silicate glass ceramics · Madhumita Goswami T Mirza A Sarkar Shobha Manikandan Sangeeta ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. AGNIESZKA SOBCZAK-KUPIEC. Articles written in Bulletin of Materials Science. Volume 36 Issue 4 August 2013 pp 755-764. Effect of calcination conditions of pork bone sludge on behaviour of hydroxyapatite in simulated body fluid · Agnieszka Sobczak-Kupiec Zbigniew ...

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Home; Journals; Bulletin of Materials Science. Thotapalli P Sastry. Articles written in Bulletin of Materials Science. Volume 34 Issue 1 February 2011 pp 177-181. Preparation and characterization of a novel bone graft composite containing bone ash and egg shell powder · Gunasekaran Krithiga Thotapalli P Sastry.

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. B V Radhakrishna Bhat. Articles written in Bulletin of Materials Science. Volume 23 Issue 2 April 2000 pp 109-117 Composites. Optimization of processing parameters for making alumina–partially stabilized zirconia laminated composites · S Deb B V Radhakrishna Bhat.

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Home; Journals; Bulletin of Materials Science. SUDHANSHU CHOUDHARY. Articles written in Bulletin of Materials Science. Volume 35 Issue 5 October 2012 pp 713-718. Theoretical study on effect of radial and axial deformation on electron transport properties in a semiconducting Si–C nanotube · Sudhanshu Choudhary ...

Development and evaluation of an electronic drug and therapeutics bulletin.

Science.gov (United States)

Alderman, Christopher P

2002-10-01

To describe the development, implementation, and initial evaluation of a paperless drug and therapeutics bulletin that is distributed by electronic mail from the pharmacy department of an Australian teaching hospital. A standardized format for the bulletin was designed and approved in February 2001. The aim of the bulletin is to facilitate the timely dissemination of concise, factual information about issues of current interest in therapeutics, drug safety, and the cost-effective use of medicines. A simple and attractive graphic design was chosen, and the hospital's clinical pharmacists and drug information staff developed an initial bank of content during the period immediately preceding the launch. The bulletin is presented as a 1-page, read-only file in Word for Windows format and was initially distributed by electronic mail to all users of the hospital's computerized communication network. As the popularity of the bulletin increased, healthcare practitioners from outside of the hospital began to request permission for inclusion on the circulation list, and the content was frequently forwarded by E-mail to workers in other hospitals and community-based settings. The bulletin is now distributed to pharmacists around Australia via 2 separate moderated discussion lists, one of which provides an archive site for previous editions. Healthcare workers in Singapore, the US, Canada, and New Zealand also receive the bulletin, which is now also abstracted by a major Australian pharmacy journal. A readership survey (also electronically distributed) was used to seek feedback after the publication of the first 12 editions. Readers indicated a high level of satisfaction with the content, format, and frequency of distribution of the materials. Although the concept and execution of this project was relatively simple, an extensive literature review did not reveal any previously published reports describing this type of approach to the distribution of a pharmacy bulletin. The

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Shweta Agrawal. Articles written in Bulletin of Materials Science. Volume 32 Issue 6 December 2009 pp 569-573 Thin Films and Nanomatter. Swift heavy ion irradiation effect on Cu-doped CdS nanocrystals embedded in PMMA · Shweta Agrawal Subodh Srivastava Sumit ...

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Home; Journals; Bulletin of Materials Science. Manoj Komath. Articles written in Bulletin of Materials Science. Volume 23 Issue 2 April 2000 pp 135-140 Biomaterials. On the development of an apatitic calcium phosphate bone cement · Manoj Komath H K Varma R Sivakumar · More Details Abstract Fulltext PDF.

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Home; Journals; Bulletin of Materials Science. Md HABIB. Articles written in Bulletin of Materials Science. Volume 41 Issue 2 April 2018 pp 56. Tuning the BODIPY core for its potential use in DSSC: a quantum chemical approach · NARENDRA NATH GHOSH Md HABIB ANUP PRAMANIK PRANAB SARKAR SOUGATA PAL.

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Home; Journals; Bulletin of Materials Science. TRAN NGOC TUYEN. Articles written in Bulletin of Materials Science. Volume 41 Issue 1 February 2018 pp 6. Lead ions removal from aqueous solution using modified carbon nanotubes · NGUYEN DUC VU QUYEN TRAN NGOC TUYEN DINH QUANG KHIEU HO VAN MINH ...

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Home; Journals; Bulletin of Materials Science. R Murugesan. Articles written in Bulletin of Materials Science. Volume 25 Issue 7 December 2002 pp 613-618 Polymers. Metal oxalate complexes as novel inorganic dopants: Studies on their effect on conducting polyaniline · R Murugesan E Subramanian · More Details ...

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Home; Journals; Bulletin of Materials Science. S Gopalakrishnan. Articles written in Bulletin of Materials Science. Volume 27 Issue 3 June 2004 pp 235-241 Polymers. Synthesis, mechanical, thermal and chemical properties of polyurethanes based on cardanol · C V Mythili A Malar Retna S Gopalakrishnan · More Details ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. E Subramanian. Articles written in Bulletin of Materials Science. Volume 25 Issue 7 December 2002 pp 613-618 Polymers. Metal oxalate complexes as novel inorganic dopants: Studies on their effect on conducting polyaniline · R Murugesan E Subramanian · More Details ...

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Home; Journals; Bulletin of Materials Science. RITWIK SARKAR. Articles written in Bulletin of Materials Science. Volume 33 Issue 3 June 2010 pp 293-298 Alloys and Steels. Utilization of steel melting electric arc furnace slag for development of vitreous ceramic tiles · Ritwik Sarkar Nar Singh Swapan Kumar Das.

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Home; Journals; Bulletin of Materials Science. K Chandra. Articles written in Bulletin of Materials Science. Volume 30 Issue 4 August 2007 pp 309-314 Biomaterials. Characteristics of porous zirconia coated with hydroxyapatite as human bones · V V Narulkar S Prakash K Chandra · More Details Abstract Fulltext PDF.

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Home; Journals; Bulletin of Materials Science. P P PRADYUMNAN. Articles written in Bulletin of Materials Science. Volume 40 Issue 5 September 2017 pp 1007-1011. Structural and magnetic studies on copper succinate dihydrate single crystals · M P BINITHA P P PRADYUMNAN · More Details Abstract Fulltext PDF.

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Home; Journals; Bulletin of Materials Science. Zhanshuang Li. Articles written in Bulletin of Materials Science. Volume 31 Issue 2 April 2008 pp 193-195 Nanomaterials. Mesoscale organization of CuO nanoslices: Formation of sphere · Jun Wang Shunxiao Zhang Zhanshuang Li Jia You Piaoping Yang Xiaoyan Jing Milin ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Shunxiao Zhang. Articles written in Bulletin of Materials Science. Volume 31 Issue 2 April 2008 pp 193-195 Nanomaterials. Mesoscale organization of CuO nanoslices: Formation of sphere · Jun Wang Shunxiao Zhang Zhanshuang Li Jia You Piaoping Yang Xiaoyan Jing Milin ...

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Home; Journals; Bulletin of Materials Science. BALDEV RAJ. Articles written in Bulletin of Materials Science. Volume 26 Issue 4 June 2003 pp 449-460 Instrumentation. Thermogravimetry-evolved gas analysis–mass spectrometry system for materials research · M Kamruddin P K Ajikumar S Dash A K Tyagi Baldev Raj.

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Home; Journals; Bulletin of Materials Science. SABRI BAYLAV. Articles written in Bulletin of Materials Science. Volume 41 Issue 2 April 2018 pp 49. Synthesis and characterization of metal ion-imprinted polymers · YASEMIN ISIKVER SABRI BAYLAV · More Details Abstract Fulltext PDF. In this study, ion-imprinted polymeric ...

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Home; Journals; Bulletin of Materials Science. XIAOWEN ZHANG. Articles written in Bulletin of Materials Science. Volume 37 Issue 4 June 2014 pp 895-902. Structural evolution, electrical and optical properties of AZO films deposited by sputtering ultra-high density target · Jiwen Xu Zupei Yang Hua Wang Xiaowen Zhang.

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Home; Journals; Bulletin of Materials Science. LIFANG ZHANG. Articles written in Bulletin of Materials Science. Volume 38 Issue 3 June 2015 pp 811-816. Fabrication and characterization of PDLLA/pyrite composite bone scaffold for osteoblast culture · Lifang Zhang Yanyan Zheng Chengdong Xiong · More Details Abstract ...

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Home; Journals; Bulletin of Materials Science. Dong Zhang. Articles written in Bulletin of Materials Science. Volume 34 Issue 1 February 2011 pp 25-28. Aqueous colloids of graphene oxide nanosheets by exfoliation of graphite oxide without ultrasonication · Tian-You Zhang Dong Zhang · More Details Abstract Fulltext PDF.

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Home; Journals; Bulletin of Materials Science. Raji George. Articles written in Bulletin of Materials Science. Volume 30 Issue 2 April 2007 pp 183-185 Nanomaterials. Synthesis, characterization and gas sensitivity of MoO3 nanoparticles · Arnab Ganguly Raji George · More Details Abstract Fulltext PDF. Nanoparticles of ...

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Home; Journals; Bulletin of Materials Science. V Vinmathi. Articles written in Bulletin of Materials Science. Volume 38 Issue 3 June 2015 pp 625-628. A green and facile approach for the synthesis of silver nanoparticles using aqueous extract of Ailanthus excelsa leaves, evaluation of its antibacterial and anticancer efficacy.

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Home; Journals; Bulletin of Materials Science. Uma Maheswar Rao. Articles written in Bulletin of Materials Science. Volume 24 Issue 6 December 2001 pp 587-593 Surface Studies. Investigation of surface modifications in ethylene propylene diene monomer (EPDM) rubber due to tracking under a.c. and d.c. voltages.

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Home; Journals; Bulletin of Materials Science. MONICA KATIYAR. Articles written in Bulletin of Materials Science. Volume 36 Issue 4 August 2013 pp 653-660. Processing and performance of organic insulators as a gate layer in organic thin film transistors fabricated on polyethylene terephthalate substrate · Saumen Mandal ...

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Home; Journals; Bulletin of Materials Science. S Muthulakshmi. Articles written in Bulletin of Materials Science. Volume 37 Issue 7 December 2014 pp 1575-1582. Effect of temperature on the AC impedance of protein and carbohydrate biopolymers · S Muthulakshmi S Iyyapushpam D Pathinettam Padiyan · More Details ...

Bulletin of Animal Health and Production in Africa: Journal ...

African Journals Online (AJOL)

Bulletin of Animal Health and Production in Africa: Journal Sponsorship. Journal Home > About the Journal > Bulletin of Animal Health and Production in Africa: Journal Sponsorship. Log in or Register to get access to full text downloads.

Nuclear Law Bulletin: Index + supplement no.56

International Nuclear Information System (INIS)

Anon.

1995-01-01

This book deals with the status of legislation governing the peaceful uses of nuclear energy in Central and Eastern European Countries. Readers are informed about regulatory and institutional developments in these countries. The Supplement to this Bulletin reproduces the Ukraine fundamental nuclear law of the 8 february 1995 on the use of nuclear energy and radiation safety. It shall establish the priority of human and environmental safety and the rights and responsibilities of citizens with regard to the use of nuclear energy, it shall regulate activities connected with the use of nuclear installations and ionizing radiation sources, and, as well, establish the legal basis for Ukraine's international commitments with respect to the use of nuclear energy. (authors). 71 refs

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Wein-Duo Yang. Articles written in Bulletin of Materials Science. Volume 36 Issue 5 October 2013 pp 779-788. Study on photocatalysis of TiO2 nanotubes prepared by methanol-thermal synthesis at low temperature · Chau Thanh Nam Wein-Duo Yang Le Minh Duc.

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. R Bajpai. Articles written in Bulletin of Materials Science. Volume 25 Issue 1 February 2002 pp 21-23 Mechanical Properties. Surface modification on PMMA : PVDF polyblend: hardening under chemical environment · R Bajpai V Mishra Pragyesh Agrawal S C Datt · More Details ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Murali Sastry. Articles written in Bulletin of Materials Science. Volume 23 Issue 3 June 2000 pp 159-163 Nanomaterials. A note on the use of ellipsometry for studying the kinetics of formation of self-assembled monolayers · Murali Sastry · More Details Abstract Fulltext PDF.

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Home; Journals; Bulletin of Materials Science. Ch Sudheer. Articles written in Bulletin of Materials Science. Volume 25 Issue 6 November 2002 pp 545-547. Tellurium purification: various techniques and limitations · D S Prasad Ch Sudheer N R Munirathnam T L Prakash · More Details Abstract Fulltext PDF. Limitations and ...

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Home; Journals; Bulletin of Materials Science. Anjum Qureshi. Articles written in Bulletin of Materials Science. Volume 29 Issue 6 November 2006 pp 605-609. Analysis of organometallics dispersed polymer composite irradiated with oxygen ions · N L Singh Anjum Qureshi A K Rakshit D K Avasthi · More Details Abstract ...

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Home; Journals; Bulletin of Materials Science. KADARKARAI MURUGAN. Articles written in Bulletin of Materials Science. Volume 40 Issue 7 December 2017 pp 1455-1462. A sensitive optical sensor based on DNA-labelled Si@SiO 2 core–shell nanoparticle for the detection of Hg 2 + ions in environmental water samples.

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Home; Journals; Bulletin of Materials Science. YONG J IANG. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1255-1261. Molecular dynamics study on the relaxation properties of bilayered graphene with defects · WEI ZHANG JIU-REN YIN PING ZHANG YAN-HUAI DING YONG J IANG.

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Home; Journals; Bulletin of Materials Science. DANUTA OLSZEWSKA. Articles written in Bulletin of Materials Science. Volume 41 Issue 1 February 2018 pp 16. Influence of the conditions of a solid-state synthesis anode material Li 4 Ti 5 O 12 on its electrochemical properties of lithium cells · DANUTA OLSZEWSKA ANNA ...

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Home; Journals; Bulletin of Materials Science. KANNAIYAN DINAKARAN. Articles written in Bulletin of Materials Science. Volume 40 Issue 7 December 2017 pp 1455-1462. A sensitive optical sensor based on DNA-labelled Si@SiO 2 core–shell nanoparticle for the detection of Hg 2 + ions in environmental water samples.

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Home; Journals; Bulletin of Materials Science. Jadu Samuel. Articles written in Bulletin of Materials Science. Volume 36 Issue 6 November 2013 pp 981-987. Green chemical incorporation of sulphate into polyoxoanions of molybdenum to nano level · Jadu Samuel S Hari Prasad M K Sreedhar · More Details Abstract Fulltext ...

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Home; Journals; Bulletin of Materials Science. V Ganesan. Articles written in Bulletin of Materials Science. Volume 28 Issue 6 October 2005 pp 609-615 Thin Films. Structural morphology of amorphous conducting carbon film · P N Vishwakarma V Prasad S V Subramanyam V Ganesan · More Details Abstract Fulltext PDF.

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Home; Journals; Bulletin of Materials Science. Amarnath. Articles written in Bulletin of Materials Science. Volume 26 Issue 4 June 2003 pp 435-439 Biomaterials. Effect of heat treatments on the hydrogen embrittlement susceptibility of API X-65 grade line-pipe steel · G Ananta Nagu Amarnath T K G Namboodhiri.

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Home; Journals; Bulletin of Materials Science. Sejal Shah. Articles written in Bulletin of Materials Science. Volume 30 Issue 5 October 2007 pp 477-480 Polymers. Study of microhardness and electrical properties of proton irradiated polyethersulfone (PES) · Nilam Shah Dolly Singh Sejal Shah Anjum Qureshi N L Singh K P ...

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Home; Journals; Bulletin of Materials Science. D K Kharat. Articles written in Bulletin of Materials Science. Volume 28 Issue 5 August 2005 pp 453-455 Ceramics and Glasses. Characterization and microstructure of porous lead zirconate titanate ceramics · B Praveenkumar H H Kumar D K Kharat · More Details Abstract ...

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Home; Journals; Bulletin of Materials Science. H P Sachin. Articles written in Bulletin of Materials Science. Volume 30 Issue 1 February 2007 pp 57-63 Electrochemistry. Polynitroaniline as brightener for zinc–nickel alloy plating from non-cyanide sulphate bath · H P Sachin Ganesha Achary Y Arthoba Naik T V Venkatesha.

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Home; Journals; Bulletin of Materials Science. Rajeev Gupta. Articles written in Bulletin of Materials Science. Volume 34 Issue 3 June 2011 pp 447-454. An investigation in InGaO3(ZnO)m pellets as cause of variability in thin film transistor characteristics · Sonachand Adhikari Rajeev Gupta Ashish Garg Deepak.

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Home; Journals; Bulletin of Materials Science. N J KARALE. Articles written in Bulletin of Materials Science. Volume 40 Issue 7 December 2017 pp 1335-1345. Chemical synthesis and characterization of nano-sized rare-earth ruthenium pyrochlore compounds Ln 2 Ru 2 O 7 (Ln = rare earth) · R A PAWAR A K NIKUMBH ...

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Home; Journals; Bulletin of Materials Science. K Mondal. Articles written in Bulletin of Materials Science. Volume 36 Issue 1 February 2013 pp 51-58. Electrochemical passivation behaviour of nanocrystalline Fe80Si20 coating in borate buffer solution · G Gupta A P Moon K Mondal · More Details Abstract Fulltext PDF.

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Home; Journals; Bulletin of Materials Science. Jiuxing Zhang. Articles written in Bulletin of Materials Science. Volume 34 Issue 4 July 2011 pp 825-828. Magnetocaloric effect of Gd5Si2Ge2 alloys in low magnetic field · Hong Zeng Chunjiang Kuang Jiuxing Zhang Ming Yue · More Details Abstract Fulltext PDF.

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Home; Journals; Bulletin of Materials Science. B P Singh. Articles written in Bulletin of Materials Science. Volume 23 Issue 1 February 2000 pp 11-16 Molecular Magnets. Synthesis and magnetic properties of one-dimensional metal oxalate networks as molecular-based magnets · B P Singh B Singh · More Details Abstract ...

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Home; Journals; Bulletin of Materials Science. Manoj Kumar. Articles written in Bulletin of Materials Science. Volume 26 Issue 3 April 2003 pp 335-341 Glasses. Optical absorption and fluorescent behaviour of titanium ions in silicate glasses · Manoj Kumar Aman Uniyal A P S Chauhan S P Singh · More Details Abstract ...

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Home; Journals; Bulletin of Materials Science. N K PANDEY. Articles written in Bulletin of Materials Science. Volume 40 Issue 2 April 2017 pp 253-262. Electrical and optical properties of ZnO–WO 3 nanocomposite and its application as a solid-state humidity sensor · VANDNA SHAKYA N K PANDEY SUNEET KUMAR ...

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Home; Journals; Bulletin of Materials Science. Y Arthoba Naik. Articles written in Bulletin of Materials Science. Volume 28 Issue 5 August 2005 pp 495-501 Thin Films. A new condensation product for zinc plating from non-cyanide alkaline bath · Y Arthoba Naik T V Venkatesha · More Details Abstract Fulltext PDF.

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. M Singh. Articles written in Bulletin of Materials Science. Volume 28 Issue 7 December 2005 pp .... Swift heavy ion irradiation effect on Cu-doped CdS nanocrystals embedded in PMMA · Shweta Agrawal Subodh Srivastava Sumit Kumar S S Sharma B Tripathi M Singh Y K Vijay.

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Home; Journals; Bulletin of Materials Science. S Pal. Articles written in Bulletin of Materials Science. Volume 24 Issue 4 August 2001 pp 415-420 Biomaterials. A novel bio-inorganic bone implant containing deglued bone, chitosan and gelatin · G Saraswathy S Pal C Rose T P Sastry · More Details Abstract Fulltext PDF.

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Home; Journals; Bulletin of Materials Science. Annie John. Articles written in Bulletin of Materials Science. Volume 25 Issue 2 April 2002 pp 141-154 Biomaterials. Bone growth response with porous hydroxyapatite granules in a critical sized lapine tibial-defect model · Annie John S Abiraman H K Varma T V Kumari P R ...

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Home; Journals; Bulletin of Materials Science. R AHMED. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1105-1110. Structural, elastic, optoelectronic and magnetic properties of CdHo 2 S 4 spinel: a first-principle study · I HATRAF O MERABIHA T SEDDIK H BALTACHE R KHENATA R ...

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Home; Journals; Bulletin of Materials Science. Rani Joseph. Articles written in Bulletin of Materials Science. Volume 26 Issue 3 April 2003 pp 343-348 Thin Films. Optimization of pH and direct imaging conditions of complexed methylene blue sensitized poly(vinyl chloride) films · M Ushamani N G Leenadeenja K Sreekumar ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. A S Singha. Articles written in Bulletin of Materials Science. Volume 31 Issue 1 February 2008 pp 7-13 Polymers. Pressure induced graft-co-polymerization of acrylonitrile onto Saccharum cilliare fibre and evaluation of some properties of grafted fibre · A S Singha Anjali Shama ...

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Home; Journals; Bulletin of Materials Science. Ganesh Sanjeev. Articles written in Bulletin of Materials Science. Volume 33 Issue 3 June 2010 pp 191-196 Thin Films and Nanomatter. Dielectric properties of electron irradiated PbZrO3 thin films · Shetty Aparna V M Jali Ganesh Sanjeev Jayanta Parui S B Krupanidhi.

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Home; Journals; Bulletin of Materials Science. M Hafez. Articles written in Bulletin of Materials Science. Volume 33 Issue 2 April 2010 pp 149-155 Polymers. Influence of granular strontium chloride as additives on some electrical and mechanical properties for pure polyvinyl alcohol · A B Elaydy M Hafez · More Details ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. S S Samal. Articles written in Bulletin of Materials Science. Volume 30 Issue 4 August 2007 pp 379-386 Polymers. Carbon nanotube reinforced polymer composites—A state of the art · S Bal S S Samal · More Details Abstract Fulltext PDF. Because of their high mechanical ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Le Minh Duc. Articles written in Bulletin of Materials Science. Volume 36 Issue 5 October 2013 pp 779-788. Study on photocatalysis of TiO2 nanotubes prepared by methanol-thermal synthesis at low temperature · Chau Thanh Nam Wein-Duo Yang Le Minh Duc · More Details ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. K Veera Brahmam. Articles written in Bulletin of Materials Science. Volume 28 Issue 5 August 2005 pp 411-414 Single Crystals. Crystal growth and reflectivity studies of Zn1–MnTe crystals · K Veera Brahmam D Raja Reddy B K Reddy · More Details Abstract Fulltext PDF.

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Zhang Lei. Articles written in Bulletin of Materials Science. Volume 34 Issue 1 February 2011 pp 161-167. Characterization on strength and toughness of welded joint for Q550 steel · Jiang Qinglei Li Yajiang Wang Juan Zhang Lei · More Details Abstract Fulltext PDF. Q550 high ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. Amit Sinha. Articles written in Bulletin of Materials Science. Volume 24 Issue 6 December 2001 pp 653-657 Bioceramics. Development of calcium phosphate based bioceramics · Amit Sinha A Ingle K R Munim S N Vaidya B P Sharma A N Bhisey · More Details Abstract Fulltext ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. HUA WANG. Articles written in Bulletin of Materials Science. Volume 36 Issue 3 June 2013 pp 389-393. Effects of Bi doping on dielectric and ferroelectric properties of PLBZT ferroelectric thin films synthesized by sol–gel processing · Hua Wang Li Liu Ji-Wen Xu Chang-Lai Yuan ...

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Home; Journals; Bulletin of Materials Science. H N Sheikh. Articles written in Bulletin of Materials Science. Volume 34 Issue 4 July 2011 pp 843-851. Synthesis and characterization of composites of mixed oxides of iron and neodymium in polymer matrix of aniline–formaldehyde · Sajdha H N Sheikh B L Kalsotra N Kumar S ...

Bulletin of Materials Science | Indian Academy of Sciences

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Home; Journals; Bulletin of Materials Science. K Rajendra Babu. Articles written in Bulletin of Materials Science. Volume 24 Issue 2 April 2001 pp 249-252 Crystal Growth. Thermal behaviour of strontium tartrate single crystals grown in gel · M H Rahimkutty K Rajendra Babu K Sreedharan Pillai M R Sudarsana Kumar C M K ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. B Swarna Latha. Articles written in Bulletin of Materials Science. Volume 37 Issue 4 June 2014 pp 883-888. Structural, spectroscopic and electrochemical study of V substituted LiTi2(PO4)3 solid electrolyte for lithium-ion batteries · A Venkateswara Rao V Veeraiah A V Prasada ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. V Bhat. Articles written in Bulletin of Materials Science. Volume 23 Issue 4 August 2000 pp 295-299 Alloys. A test for diffusional coherency strain hypothesis in the discontinuous precipitation in Mg–Al alloy · K T Kashyap C Ramachandra V Bhat B Chatterji · More Details Abstract ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. M Mandal. Articles written in Bulletin of Materials Science. Volume 37 Issue 4 June 2014 pp 743-752. Porous copper template from partially spark plasma-sintered Cu–Zn aggregate via dezincification · M Mandal D Singh Gouthama B S Murty S Sangal K Mondal · More Details ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. B L Kalsotra. Articles written in Bulletin of Materials Science. Volume 34 Issue 4 July 2011 pp 843-851. Synthesis and characterization of composites of mixed oxides of iron and neodymium in polymer matrix of aniline–formaldehyde · Sajdha H N Sheikh B L Kalsotra N Kumar S ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. S Roy. Articles written in Bulletin of Materials Science. Volume 25 Issue 6 November 2002 pp 513-515. Improved zinc oxide film for gas sensor applications · S Roy S Basu · More Details Abstract Fulltext PDF. Zinc oxide (ZnO) is a versatile material for different commercial ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. T Bhimasankaram. Articles written in Bulletin of Materials Science. Volume 23 Issue 6 December 2000 pp 483-489 Oxide Ceramics. Effect of HIPing on conductivity and impedance measurements of DyBi5Fe2Ti3O18 ceramics · N V Prasad G Prasad Mahendra Kumar S V ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. S K Biswas. Articles written in Bulletin of Materials Science. Volume 33 Issue 3 June 2010 pp 251-255 Polymers. Effect of substrate roughness on growth of diamond by hot filament CVD · Awadesh K Mallik S R Binu L N Satapathy Chandrabhas Narayana Md Motin Seikh S A ...

Archives: Bulletin of the Chemical Society of Ethiopia

African Journals Online (AJOL)

Items 1 - 50 of 74 ... Archives: Bulletin of the Chemical Society of Ethiopia. Journal Home > Archives: Bulletin of the Chemical Society of Ethiopia. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K Sahu. Articles written in Bulletin of Materials Science. Volume 32 Issue 3 June 2009 pp 285-294. Nafion and modified-Nafion membranes for polymer electrolyte fuel cells: An overview · A K Sahu S Pitchumani P Sridhar A K Shukla · More Details Abstract Fulltext PDF.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. Anhua Wu. Articles written in Bulletin of Materials Science. Volume 27 Issue 4 August 2004 pp 333-336 Crystal Growth. Bridgman growth and defects of Nd : Sr3Ga2Ge4O14 laser crystals · Jiaxuan Ding Anhua Wu Jiayue Xu · More Details Abstract Fulltext PDF.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. LING YANG. Articles written in Bulletin of Materials Science. Volume 36 Issue 3 June 2013 pp 389-393. Effects of Bi doping on dielectric and ferroelectric properties of PLBZT ferroelectric thin films synthesized by sol–gel processing · Hua Wang Li Liu Ji-Wen Xu Chang-Lai Yuan ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. L C GUPTA. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1121-1125. High-pressure studies of superconductivity in BiO 0.75 F 0.25 BiS 2 · ZEBA HAQUE GOHIL S THAKUR GANESAN KALAI SELVAN SONACHALAM ARUMUGAM L C ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. M Petrič. Articles written in Bulletin of Materials Science. Volume 34 Issue 1 February 2011 pp 113-119. Performance of waterborne acrylic surface coatings on wood impregnated with Cu-ethanolamine preservatives · M Humar M Pavlič D Žlindra M Tomažič M Petrič.

75 FR 22805 - Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of...

Science.gov (United States)

2010-04-30

... GENERAL SERVICES ADMINISTRATION [Proposed GSA Bulletin FTR 10-XXX; Docket 2010-0009; Sequence 1] Federal Travel Regulation; Relocation Allowances; Standard Data Dictionary for Collection of Transaction... GSA is posting online a proposed FTR bulletin that contains the data dictionary that large Federal...

Distribution of the FMR1 gene in females by race/ethnicity: women with diminished ovarian reserve versus women with normal fertility (SWAN study).

Science.gov (United States)

Pastore, Lisa M; Young, Steven L; Manichaikul, Ani; Baker, Valerie L; Wang, Xin Q; Finkelstein, Joel S

2017-01-01

To study whether reported, but inconsistent, associations between the FMR1 CGG repeat lengths in the intermediate, high normal, or low normal range differentiate women diagnosed with diminished ovarian reserve (DOR) from population controls and whether associations vary by race/ethnic group. Case-control study. Academic and private fertility clinics. DOR cases (n = 129; 95 Whites, 22 Asian, 12 other) from five U.S. fertility clinics were clinically diagnosed, with regular menses and no fragile X syndrome family history. Normal fertility controls (n = 803; 386 Whites, 219 African-Americans, 102 Japanese, 96 Chinese) from the United States-based SWAN Study had one or more menstrual period in the 3 months pre-enrollment, one or more pregnancy, no history of infertility or hormone therapy, and menopause ≥46 years. Previously, the SWAN Chinese and Japanese groups had similar FMR1 CGG repeat lengths, thus they were combined. None. FMR1 CGG repeat lengths. Median CGG repeats were nearly identical by case/control group. DOR cases had fewer CGG repeats in the shorter FMR1 allele than controls among Whites, but this was not significant among Asians. White cases had fewer CGG repeats in the shorter allele than Asian cases. No significant differences were found in the high normal/intermediate range between cases and controls or by race/ethnic group within cases in the longer allele. This study refutes prior reports of an association between DOR and high normal/intermediate repeats and confirms an association between DOR and low normal repeats in Whites. Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Updating default depths in the ISC bulletin

Science.gov (United States)

Bolton, Maiclaire K.; Storchak, Dmitry A.; Harris, James

2006-09-01

The International Seismological Centre (ISC) publishes the definitive global bulletin of earthquake locations. In the ISC bulletin, we aim to obtain a free depth, but often this is not possible. Subsequently, the first option is to obtain a depth derived from depth phases. If depth phases are not available, we then use the reported depth from a reputable local agency. Finally, as a last resort, we set a default depth. In the past, common depths of 10, 33, or multiples of 50 km have been assigned. Assigning a more meaningful default depth, specific to a seismic region will increase the consistency of earthquake locations within the ISC bulletin and allow the ISC to publish better positions and magnitude estimates. It will also improve the association of reported secondary arrivals to corresponding seismic events. We aim to produce a global set of default depths, based on a typical depth for each area, from well-constrained events in the ISC bulletin or where depth could be constrained using a consistent set of depth phase arrivals provided by a number of different reporters. In certain areas, we must resort to using other assumptions. For these cases, we use a global crustal model (Crust2.0) to set default depths to half the thickness of the crust.

Market bulletin - March 1989

International Nuclear Information System (INIS)

1989-01-01

This bulletin deals with the brazilian electric power consumption in March 1989, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - August 1990

International Nuclear Information System (INIS)

1990-01-01

This bulletin deals with the brazilian electric power consumption in August 1990, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - April 1991

International Nuclear Information System (INIS)

1991-01-01

This bulletin deals with the brazilian electric power consumption in April 1991, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - December 1990

International Nuclear Information System (INIS)

1990-01-01

This bulletin deals with the brazilian electric power consumption in December 1990, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - December 1989

International Nuclear Information System (INIS)

1989-01-01

This bulletin deals with the brazilian electric power consumption in December 1989, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - February 1991

International Nuclear Information System (INIS)

1991-01-01

This bulletin deals with the brazilian electric power consumption in February 1991, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - January 1990

International Nuclear Information System (INIS)

1990-01-01

This bulletin deals with the brazilian electric power consumption in January 1990, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - September 1990

International Nuclear Information System (INIS)

1990-01-01

This bulletin deals with the brazilian electric power consumption in September 1990, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - November 1990

International Nuclear Information System (INIS)

1990-01-01

This bulletin deals with the brazilian electric power consumption in November 1990, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - July 1990

International Nuclear Information System (INIS)

1990-01-01

This bulletin deals with the brazilian electric power consumption in July 1990, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - March 1991

International Nuclear Information System (INIS)

1991-01-01

This bulletin deals with the brazilian electric power consumption in March 1991, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - September 1989

International Nuclear Information System (INIS)

1989-01-01

This bulletin deals with the brazilian electric power consumption in September 1989, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - April 1989

International Nuclear Information System (INIS)

1989-01-01

This bulletin deals with the brazilian electric power consumption in April 1989, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - June 1990

International Nuclear Information System (INIS)

1990-01-01

This bulletin deals with the brazilian electric power consumption in June 1990, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Market bulletin - March 1990

International Nuclear Information System (INIS)

1990-01-01

This bulletin deals with the brazilian electric power consumption in March 1990, containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. (C.G.C.)

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. P K Parhi. Articles written in Bulletin of Materials Science. Volume 24 Issue 2 April 2001 pp 143-149. Failure analysis of multiple delaminated composite plates due to bending and impact · P K Parhi S K Bhattacharyya P K Sinha · More Details Abstract Fulltext PDF. The present ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A S Prakash. Articles written in Bulletin of Materials Science. Volume 29 Issue 4 August 2006 pp 339-345 Ceramics and Glasses. Solution-combustion synthesis of Bi1–LnO1.5 (Ln = Y and La–Yb) oxide ion conductors · Manjunath B Bellakki A S Prakash C Shivakumara M S ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K B R Varma. Articles written in Bulletin of Materials Science. Volume 30 Issue 6 December 2007 pp 567-570 Ceramics and Glasses. Microwave synthesis and sintering characteristics of CaCu3Ti4O12 · P Thomas L N Sathapathy K Dwarakanath K B R Varma · More Details ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. U S Sajeev. Articles written in Bulletin of Materials Science. Volume 27 Issue 2 April 2004 pp 155-161 Magnetic Materials. Magnetic field induced assembling of nanoparticles in ferrofluidic liquid thin films based on NiFe1-Fe2O4 · V S Abraham S Swapna Nair S Rajesh U S ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. S R Dhage. Articles written in Bulletin of Materials Science. Volume 27 Issue 1 February 2004 pp 43-45 Dielectric Materials. Nonlinear – characteristics study of doped SnO2 · S R Dhage V Ravi S K Date · More Details Abstract Fulltext PDF. When tin oxide is doped with ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K Prasad. Articles written in Bulletin of Materials Science. Volume 27 Issue 6 December 2004 pp 547-553 Glasses and Ceramics. Impedance analysis of Pb2Sb3LaTi5O18 ceramic · C K Suman K Prasad R N P Choudhary · More Details Abstract Fulltext PDF. Polycrystalline ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. D K Avasthi. Articles written in Bulletin of Materials Science. Volume 27 Issue 3 June 2004 pp 263-267 Polymers. Electrical properties of ion irradiated polypropylene films · N L Singh Anita Sharma V Shrinet A K Rakshit D K Avasthi · More Details Abstract Fulltext PDF. The effect ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. V Shrinet. Articles written in Bulletin of Materials Science. Volume 27 Issue 3 June 2004 pp 263-267 Polymers. Electrical properties of ion irradiated polypropylene films · N L Singh Anita Sharma V Shrinet A K Rakshit D K Avasthi · More Details Abstract Fulltext PDF. The effect of ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. A K Rakshit. Articles written in Bulletin of Materials Science. Volume 27 Issue 3 June 2004 pp 263-267 Polymers. Electrical properties of ion irradiated polypropylene films · N L Singh Anita Sharma V Shrinet A K Rakshit D K Avasthi · More Details Abstract Fulltext PDF. The effect ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. D S Prasad. Articles written in Bulletin of Materials Science. Volume 25 Issue 2 April 2002 pp 79-83 Materials Synthesis. Preparation of high purity tellurium by zone refining · N R Munirathnam D S Prasad Ch Sudheer A J Singh T L Prakash · More Details Abstract Fulltext PDF.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. P M Raole. Articles written in Bulletin of Materials Science. Volume 34 Issue 1 February 2011 pp 81-88. Effect of ion beam irradiation on metal particle doped polymer composites · N L Singh Sejal Shah Anjum Qureshi A Tripathi F Singh D K Avasthi P M Raole · More Details ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. LI-XIA YANG. Articles written in Bulletin of Materials Science. Volume 34 Issue 2 April 2011 pp 233-237. Shape control synthesis of low-dimensional calcium sulfate · Li-Xia Yang Yan-Feng Meng Ping Yin Ying-Xia Yang Ying-Ying Tang Lai-Fen Qin · More Details Abstract ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. B N Dev. Articles written in Bulletin of Materials Science. Volume 29 Issue 2 April 2006 pp 101-105 Polymers. Proton microbeam irradiation effects on PtBA polymer · J Kamila S Roy K Bhattacharjee B Rout B N Dev R Guico J Wang A W Haberl P Ayyub P V Satyam.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K R Rajesh. Articles written in Bulletin of Materials Science. Volume 37 Issue 1 February 2014 pp 95-99. High mobility polymer gated organic field effect transistor using zinc phthalocyanine · K R Rajesh V Kannan M R Kim Y S Chae J K Rhee · More Details Abstract Fulltext PDF.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. N L Singh. Articles written in Bulletin of Materials Science. Volume 27 Issue 3 June 2004 pp 263-267 Polymers. Electrical properties of ion irradiated polypropylene films · N L Singh Anita Sharma V Shrinet A K Rakshit D K Avasthi · More Details Abstract Fulltext PDF. The effect ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. Hui Shen. Articles written in Bulletin of Materials Science. Volume 30 Issue 2 April 2007 pp 101-104 Single Crystals. Piezoelectric properties of Sr3Ga2Ge4O14 single crystals · Anhua Wu Jiayue Xu Juan Zhou Hui Shen · More Details Abstract Fulltext PDF. A new piezoelectric ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K V Shah. Articles written in Bulletin of Materials Science. Volume 26 Issue 7 December 2003 pp 715-720 Glasses and Ceramics. Preparation and studies of some thermal, mechanical and optical properties of Al2O3(1 – )NaPO3 glass system · K V Shah V Sudarsan M ...

Guidelines for determining flood flow frequency—Bulletin 17C

Science.gov (United States)

England, John F.; Cohn, Timothy A.; Faber, Beth A.; Stedinger, Jery R.; Thomas, Wilbert O.; Veilleux, Andrea G.; Kiang, Julie E.; Mason, Robert R.

2018-03-29

Accurate estimates of flood frequency and magnitude are a key component of any effective nationwide flood risk management and flood damage abatement program. In addition to accuracy, methods for estimating flood risk must be uniformly and consistently applied because management of the Nation’s water and related land resources is a collaborative effort involving multiple actors including most levels of government and the private sector.Flood frequency guidelines have been published in the United States since 1967, and have undergone periodic revisions. In 1967, the U.S. Water Resources Council presented a coherent approach to flood frequency with Bulletin 15, “A Uniform Technique for Determining Flood Flow Frequencies.” The method it recommended involved fitting the log-Pearson Type III distribution to annual peak flow data by the method of moments.The first extension and update of Bulletin 15 was published in 1976 as Bulletin 17, “Guidelines for Determining Flood Flow Frequency” (Guidelines). It extended the Bulletin 15 procedures by introducing methods for dealing with outliers, historical flood information, and regional skew. Bulletin 17A was published the following year to clarify the computation of weighted skew. The next revision of the Bulletin, the Bulletin 17B, provided a host of improvements and new techniques designed to address situations that often arise in practice, including better methods for estimating and using regional skew, weighting station and regional skew, detection of outliers, and use of the conditional probability adjustment.The current version of these Guidelines are presented in this document, denoted Bulletin 17C. It incorporates changes motivated by four of the items listed as “Future Work” in Bulletin 17B and 30 years of post-17B research on flood processes and statistical methods. The updates include: adoption of a generalized representation of flood data that allows for interval and censored data types; a new method

Safety Bulletin 2013-1: When the alarm rings, you must leave!

CERN Multimedia

HSE Unit

2013-01-01

The HSE Unit just released the Safety Bulletin 2013-1 entitled “When the alarm rings, you must leave!”. The Bulletin is available on EDMS under the following number: 1307611. Be reminded  that HSE Safety Bulletins are published in English and French and share feedbacks of incidents/near miss/accidents that happened on the CERN site with the aim to improve prevention.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. G P Nayaka. Articles written in Bulletin of Materials Science. Volume 37 Issue 3 May 2014 pp 705-711. Structural, electrical and electrochemical behaviours of LiNi0.4M0.1Mn1.5O4 ( = Al, Bi) as cathode material for Li-ion batteries · G P Nayaka J Manjanna K C Anjaneya P ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. F Wang. Articles written in Bulletin of Materials Science. Volume 34 Issue 5 August 2011 pp 1033-1037. Synthesis of Mn-doped CeO2 nanorods and their application as humidity sensors · C H Hu C H Xia F Wang M Zhou P F Yin X Y Han · More Details Abstract Fulltext PDF.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. S K Singh. Articles written in Bulletin of Materials Science. Volume 25 Issue 6 November 2002 pp 561-563. Synthesis of SiC from rice husk in a plasma reactor · S K Singh B C Mohanty S Basu · More Details Abstract Fulltext PDF. A new route for production of SiC from rice husk ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. T K Bhattacharya. Articles written in Bulletin of Materials Science. Volume 26 Issue 7 December 2003 pp 703-706 Cements. Solid state sintering of lime in presence of La2O3 and CeO2 · T K Bhattacharya A Ghosh H S Tripathi S K Das · More Details Abstract Fulltext PDF.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. C H Xia. Articles written in Bulletin of Materials Science. Volume 34 Issue 5 August 2011 pp 1033-1037. Synthesis of Mn-doped CeO2 nanorods and their application as humidity sensors · C H Hu C H Xia F Wang M Zhou P F Yin X Y Han · More Details Abstract Fulltext PDF.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. G Prasad. Articles written in Bulletin of Materials Science. Volume 23 Issue 5 October 2000 pp 431-437 High T c Superconductors. Studies on electrical properties of SrBi4Ti4–3Fe4O15 · N Venkat Ramulu G Prasad S V Suryanarayana T Bhima Sankaram · More Details ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. K C Anjaneya. Articles written in Bulletin of Materials Science. Volume 37 Issue 3 May 2014 pp 705-711. Structural, electrical and electrochemical behaviours of LiNi0.4M0.1Mn1.5O4 ( = Al, Bi) as cathode material for Li-ion batteries · G P Nayaka J Manjanna K C Anjaneya P ...

Publication of the Bulletin in 2006

CERN Multimedia

2005-01-01

Deadlines for the submission of announcements The table below lists the 2006 publication dates for the paper version of the Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12.00 midday on Tuesdays at the latest and that, for organisational reasons, we will no longer be able to accept those which reach us after this deadline. Bulletin publication 2006 Bulletin No. Week number Publication date Submission of announcements (before 12.00 midday) 3-4 Monday 16 January Tuesday 10 January 5-6 Monday 30 January Tuesday 24 January 7-8 Monday 13 February Tuesday 7 February 9-10 Monday 27 February Tuesday 21 February 11-12 Monday 13 March Tuesday 7 March 13-14 Monday 27 March Tuesday 21 March 15-16 Monday 10 April Tuesday 4 April 17-18 Monday 24 April Tuesday 18 April 19-20 Monday 8 May Tuesday 2 May 21-22 Monday 22 May Tuesday 16 May 23-24 Monday 5 June Tuesday 30 May 2...

Publication of the Bulletin in 2006

CERN Multimedia

Publications Section, DSU-CO

2006-01-01

Deadlines for the submission of announcements The table below lists the 2006 publication dates for the paper version of the Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12.00 midday on Tuesdays at the latest and that, for organisational reasons, we will no longer be able to accept those which reach us after this deadline. Bulletin publication 2006 Bulletin No. Week number Publication date Submission of announcements (before 12.00 midday) 5-6 Monday 30 January Tuesday 24 January 7-8 Monday 13 February Tuesday 7 February 9-10 Monday 27 February Tuesday 21 February 11-12 Monday 13 March Tuesday 7 March 13-14 Monday 27 March Tuesday 21 March 15-16 Monday 10 April Tuesday 4 April 17-18 Monday 24 April Tuesday 18 April 19-20 Monday 8 May Tuesday 2 May 21-22 Monday 22 May Tuesday 16 May 23-24 Monday 5 June Tuesday 30 May 25-26 Monday 19 June Tuesday 13 June 27-2...

CERN Bulletin publication schedule for 2016

CERN Multimedia

2015-01-01

The table below lists the 2016 publication dates for the CERN Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12 noon on Tuesdays at the latest.   Bulletin No. (corresponding to the week number) Submission deadline for announcements (before 12 noon) Publication of Bulletin (web version) 3-4 Tuesday 12 January Friday 15 January 5-6 Tuesday 26 January Friday 29 January 7-8 Tuesday 9 February Friday 12 February 9-10 Tuesday 23 February Friday 26 February 11-12 Tuesday 8 March Friday 11 March 13-14 MONDAY 21 March THURSDAY 24 March 15-16 Tuesday 5 April Friday 8 April 17-18-19 Tuesday 19 April Friday 22 April 20-21 Tuesday 10 May Friday 13 May 22-23 Tuesday 24 May Friday 27 May 24-25 Tuesday 7 June Friday 10 June 26-27 Tuesday 21 June Friday 24 June 28-29 Tuesday 5 July Friday 8 July 30-31-32 Tuesday 19 July Friday 22 July 33-34-35 Tuesday 9 August Friday 12 August 3...

CERN Bulletin publication schedule for 2015

CERN Multimedia

2014-01-01

The table below lists the 2015 publication dates for the CERN Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12 noon on Tuesdays at the latest.   .tftable {font-size:12px;color:#333333;width:100%;border-width: 1px;border-color: #a9a9a9;border-collapse: collapse;} .tftable th {font-size:12px;background-color:#b8b8b8;border-width: 1px;padding: 8px;border-style: solid;border-color: #a9a9a9;text-align:left;} .tftable tr {background-color:#ffffff;} .tftable td {font-size:12px;border-width: 1px;padding: 8px;border-style: solid;border-color: #a9a9a9;} .tftable tr:hover {background-color:#ffff99;} Bulletin No. (corresponding to the week number) Submission deadline for announcements (before 12 noon) Publication of Bulletin (web version) 4-5 Tuesday 13 January Friday 16 January 6-7 Tuesday 26 January Friday 30 January 8-9 Tuesday 10 February Friday 13 February 10-11 Tuesday 24 February ...

Welcome to the new eBulletin!

CERN Multimedia

Corinne Pralavorio

You are now reading one of the new sections of the new eBulletin launched this week. Entitled "What's New", this section will allow us to tell you about important news and events when they occur, without having to wait for a new Bulletin update. So, when the Higgs Boson is discovered, you will be among the first to know! This column will also contain links to the new items included in the weekly update of the electronic Bulletin. Under this section, you will find several other practical sections:"Four Your Eyes Only", presenting a striking photo or a video, "What's on Today", detailing the day's seminars and other events, and "Under the CERN Sky", giving the latest weather information. There is also a list of useful links at the bottom of the column. Concerning your usual section: the "News Articles" can be accessed directly from links on the home page, while other information items are accessible from the relevant menu headings. In addition, you will now find a set of tools at the end of each article, enabli...

Publication of a double issue of the Bulletin at Easter

CERN Multimedia

Publications Section

2005-01-01

During the Easter period, there will be a single issue of the Bulletin (No. 12-13/2005) covering the weeks of 21 and 28 March. The deadline for articles to appear in this double issue, both in the publications section and in the Staff Association's pages, will be midday on Tuesday, 15 March. No Bulletin will be distributed on 28 March. The deadline for articles to appear in the following issue of the Bulletin, No. 14/2005, will be midday on Tuesday 29 March. Publications Section DSU-CO Tel. 79971

Publication of a double issue of the Bulletin at Easter

CERN Document Server

Publications Section

2005-01-01

During the Easter period, there will be a single issue of the Bulletin (No. 12-13/2005) covering the weeks of 21 and 28 March. The deadline for articles to appear in this double issue, both in the publications section and in the Staff Association's pages, will be midday on Tuesday, 15 March. No Bulletin will be distributed on 28 March. The deadline for articles to appear in the following issue of the Bulletin, No. 14/2005, will be midday on Tuesday 29 March. Publications Section SG/CO Tel. 79971

Archives: Bulletin of Animal Health and Production in Africa

African Journals Online (AJOL)

Items 1 - 50 of 60 ... Archives: Bulletin of Animal Health and Production in Africa. Journal Home > Archives: Bulletin of Animal Health and Production in Africa. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Journal Home · ABOUT THIS JOURNAL · Advanced Search ...

Validation of a screening tool for the rapid and reliable detection of CGG trinucleotide repeat expansions in FMR1.

Science.gov (United States)

Basehore, Monica J; Marlowe, Natalia M; Jones, Julie R; Behlendorf, Deborah E; Laver, Thomas A; Friez, Michael J

2012-06-01

Most individuals with intellectual disability and/or autism are tested for Fragile X syndrome at some point in their lifetime. Greater than 99% of individuals with Fragile X have an expanded CGG trinucleotide repeat motif in the promoter region of the FMR1 gene, and diagnostic testing involves determining the size of the CGG repeat as well as methylation status when an expansion is present. Using a previously described triplet repeat-primed polymerase chain reaction, we have performed additional validation studies using two cohorts with previous diagnostic testing results available for comparison purposes. The first cohort (n=88) consisted of both males and females and had a high percentage of abnormal samples, while the second cohort (n=624) consisted of only females and was not enriched for expansion mutations. Data from each cohort were completely concordant with the results previously obtained during the course of diagnostic testing. This study further demonstrates the utility of using laboratory-developed triplet repeat-primed FMR1 testing in a clinical setting.

Early Retinal Defects in Fmr1-/y Mice: Toward a Critical Role of Visual Dys-Sensitivity in the Fragile X Syndrome Phenotype?

Science.gov (United States)

Perche, Olivier; Felgerolle, Chloé; Ardourel, Maryvonne; Bazinet, Audrey; Pâris, Arnaud; Rossignol, Rafaëlle; Meyer-Dilhet, Géraldine; Mausset-Bonnefont, Anne-Laure; Hébert, Betty; Laurenceau, David; Montécot-Dubourg, Céline; Menuet, Arnaud; Bizot, Jean-Charles; Pichon, Jacques; Ranchon-Cole, Isabelle; Briault, Sylvain

2018-01-01

Fragile X Syndrome (FXS) is caused by a deficiency in Fragile X Mental Retardation Protein (FMRP) leading to global sensorial abnormalities, among which visual defects represent a critical part. These visual defects are associated with cerebral neuron immaturity especially in the primary visual cortex. However, we recently demonstrated that retinas of adult Fmr1 -/y mice, the FXS murine model, present molecular, cellular and functional alterations. However, no data are currently available on the evolution pattern of such defects. As retinal stimulation through Eye Opening (EO) is a crucial signal for the cerebral visual system maturation, we questioned the precocity of molecular and functional retinal phenotype. To answer this question, we studied the retinal molecular phenotype of Fmr1 -/y mice before EO until adult age and the consequences of the retinal loss of Fmrp on retinal function in young and adult mice. We showed that retinal molecular defects are present before EO and remain stable at adult age, leading to electrophysiological impairments without any underlying structural changes. We underlined that loss of Fmrp leads to a wide range of defects in the retina, settled even before EO. Our work demonstrates a critical role of the sensorial dysfunction in the Fmr1 -/y mice overall phenotype, and provides evidence that altered peripheral perception is a component of the sensory processing defect in FXS conditions.

Federal Government Electronic Bulletin Boards: An Assessment with Policy Recommendations.

Science.gov (United States)

Bertot, John Carlo; McClure, Charles R.

1993-01-01

Identifies and analyzes federal government electronic bulletin boards; assesses the types of information available to users, including costs and technological access issues; discusses federal information policy; and considers the role of federal bulletin boards in accessing and managing electronic government information. (Contains 29 references.)…

Publication of a double weekly bulletin FOR JEÛNE GENEVOIS

CERN Multimedia

2002-01-01

Publication of a double weekly bulletin FOR JEÛNE GENEVOIS A double issue of the Weekly Bulletin (nos 36-37/2001) will cover events at CERN from 2 September to 13 September 2002. Items for publication in this double edition should reach the Publications Section or the Staff Association, as appropriate, before midday on Tuesday 27 August. There will therefore be no Bulletin distribution on Friday 6 September. Announcements for publication in the next issue (no 38/2001) should reach the Publication Section or the Staff Association, as appropriate, on Tuesday 10 September by noon. Publications Section/ ETT Tel. 73830

Bulletin of International Simultaneous Observations

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The publication of the Bulletin of International Simultaneous Observations, began July 1, 1875, with daily maps added in 1877. It was published for distribution...

How to design and establish a computer bulletin board to support inventors

Energy Technology Data Exchange (ETDEWEB)

1991-12-31

This booklet is a ``how-to handbook`` to demonstrate the development of an interactive electronic bulletin board as a support network for independent inventors and small business inventors. This will explain step-by-step, how Linking Alaskan Minds{trademark}, the Alaskan model of an interactive computer bulletin board system, was developed and designed to serve as a successfully working, interactive computer bulletin board that links and supports independent inventors in Alaska.

Nuclear Law Bulletin No. 92 - Volume 2013/2

International Nuclear Information System (INIS)

Chennoufi, F.; Pelzer, N.; Martirosyan, A.; Cook, H.; Fischer, D.; Clark, S.; Rothschild, T.; Touitou-Durand, F.; Guezou, O.; Manson, S.; Tafili, V.; Bolger, I.; Majerus, P.; Sieczak, K.; Sousa-Ferro, M.; Pospisil, M.; Skraban, A.; Portmann-Bochsler, F.; Shvytai, V.; Puig, D.; Durand, A.; Rivera, S.; Reyners, P.; Ryan-Taix, V.

2013-01-01

The Nuclear Law Bulletin is a unique international publication for both professionals and academics in the field of nuclear law. It provides authoritative and comprehensive information on nuclear law developments. Published twice a year in both English and French, it features topical articles written by renowned legal experts, covers nuclear legislative developments worldwide and reports on relevant case law, bilateral and international agreements and regulatory activities of international organisations. The topical articles of this issue deal with: - Uranium mining and production: A legal perspective on regulating an important resource by Lisa Thiele; - Turkish nuclear legislation: Developments for a nuclear newcomer by Erinc Ercan and Horst Schneider; - Nuclear law and environmental law in the licensing of nuclear installations by Christian Raetzke

How to design and establish a computer bulletin board to support inventors

Energy Technology Data Exchange (ETDEWEB)

1991-01-01

This booklet is a how-to handbook'' to demonstrate the development of an interactive electronic bulletin board as a support network for independent inventors and small business inventors. This will explain step-by-step, how Linking Alaskan Minds{trademark}, the Alaskan model of an interactive computer bulletin board system, was developed and designed to serve as a successfully working, interactive computer bulletin board that links and supports independent inventors in Alaska.

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 1 .... Na + /B 3 + phosphor has a potential application in white light-emitting diodes based ... College of Mathematics and Physics, Jinggangshan University, Ji'an 343009, China ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 38; Issue 3 ... In this study, a modified model for the application of the thermionic and hopping current ... Departments of Mathematics and Physics, Arab American University, Jenin 240, ...

Qi Liu - Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. QI LIU. Articles written in Bulletin of Materials Science. Volume 34 Issue 2 April 2011 pp 183-189. Study of structural transformations and phases formation upon calcination of Zn–Ni–Al hydrotalcite nanosheets · Zhanshuang Li Yanchao Song Jun Wang Qi Liu Piaoping Yang ...

Early Retinal Defects in Fmr1−/y Mice: Toward a Critical Role of Visual Dys-Sensitivity in the Fragile X Syndrome Phenotype?

Science.gov (United States)

Perche, Olivier; Felgerolle, Chloé; Ardourel, Maryvonne; Bazinet, Audrey; Pâris, Arnaud; Rossignol, Rafaëlle; Meyer-Dilhet, Géraldine; Mausset-Bonnefont, Anne-Laure; Hébert, Betty; Laurenceau, David; Montécot-Dubourg, Céline; Menuet, Arnaud; Bizot, Jean-Charles; Pichon, Jacques; Ranchon-Cole, Isabelle; Briault, Sylvain

2018-01-01

Fragile X Syndrome (FXS) is caused by a deficiency in Fragile X Mental Retardation Protein (FMRP) leading to global sensorial abnormalities, among which visual defects represent a critical part. These visual defects are associated with cerebral neuron immaturity especially in the primary visual cortex. However, we recently demonstrated that retinas of adult Fmr1−/y mice, the FXS murine model, present molecular, cellular and functional alterations. However, no data are currently available on the evolution pattern of such defects. As retinal stimulation through Eye Opening (EO) is a crucial signal for the cerebral visual system maturation, we questioned the precocity of molecular and functional retinal phenotype. To answer this question, we studied the retinal molecular phenotype of Fmr1−/y mice before EO until adult age and the consequences of the retinal loss of Fmrp on retinal function in young and adult mice. We showed that retinal molecular defects are present before EO and remain stable at adult age, leading to electrophysiological impairments without any underlying structural changes. We underlined that loss of Fmrp leads to a wide range of defects in the retina, settled even before EO. Our work demonstrates a critical role of the sensorial dysfunction in the Fmr1−/y mice overall phenotype, and provides evidence that altered peripheral perception is a component of the sensory processing defect in FXS conditions. PMID:29681800

Early Retinal Defects in Fmr1−/y Mice: Toward a Critical Role of Visual Dys-Sensitivity in the Fragile X Syndrome Phenotype?

Directory of Open Access Journals (Sweden)

Olivier Perche

2018-04-01

Full Text Available Fragile X Syndrome (FXS is caused by a deficiency in Fragile X Mental Retardation Protein (FMRP leading to global sensorial abnormalities, among which visual defects represent a critical part. These visual defects are associated with cerebral neuron immaturity especially in the primary visual cortex. However, we recently demonstrated that retinas of adult Fmr1−/y mice, the FXS murine model, present molecular, cellular and functional alterations. However, no data are currently available on the evolution pattern of such defects. As retinal stimulation through Eye Opening (EO is a crucial signal for the cerebral visual system maturation, we questioned the precocity of molecular and functional retinal phenotype. To answer this question, we studied the retinal molecular phenotype of Fmr1−/y mice before EO until adult age and the consequences of the retinal loss of Fmrp on retinal function in young and adult mice. We showed that retinal molecular defects are present before EO and remain stable at adult age, leading to electrophysiological impairments without any underlying structural changes. We underlined that loss of Fmrp leads to a wide range of defects in the retina, settled even before EO. Our work demonstrates a critical role of the sensorial dysfunction in the Fmr1−/y mice overall phenotype, and provides evidence that altered peripheral perception is a component of the sensory processing defect in FXS conditions.

ENGINEERING BULLETIN: SUPERCRITICAL WATER OXIDATION

Science.gov (United States)

This engineering bulletin presents a description and status of supercritical water oxidation technology, a summary of recent performance tests, and the current applicability of this emerging technology. This information is provided to assist remedial project managers, contractors...

Bulletin of the Chemical Society of Ethiopia: About this journal

African Journals Online (AJOL)

Bulletin of the Chemical Society of Ethiopia: About this journal. Journal Home > Bulletin of the Chemical Society of Ethiopia: About this journal. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register · Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue ...

Age- and region-specific imbalances of basal amino acids and monoamine metabolism in limbic regions of female Fmr1 knock-out mice.

Science.gov (United States)

Gruss, Michael; Braun, Katharina

2004-07-01

The Fragile X syndrome, a common form of mental retardation in humans, originates from the loss of expression of the Fragile X mental retardation gene leading to the absence of the encoded Fragile X mental retardation protein 1 (FMRP). A broad pattern of morphological and behavioral abnormalities is well described for affected humans as well as Fmr1 knock-out mice, a transgenic animal model for the human Fragile X syndrome. In the present study, we examined neurochemical differences between female Fmr1 knock-out and wildtype mice with particular focus on neurotransmission. Significant age- and region-specific differences of basal tissue neurotransmitter and metabolite levels measured by high performance liquid chromatography were found. Those differences were more numerous in juvenile animals (postnatal day (PND) 28-31) compared to adults (postnatal day 209-221). In juvenile female knock-out mice, especially aspartate and taurine were increased in cortical regions, striatum, cerebellum, and brainstem. Furthermore, compared to the wildtype animals, the juvenile knock-out mice displayed an increased level of neuronal inhibition in the hippocampus and brainstem reflected by decreased ratios of (aspartate + glutamate)/(taurine + GABA), as well as an increased dopamine (DA) turnover in cortical regions, striatum, and hippocampus. These results provide the first evidence that the lack of FMRP expression in female Fmr1 knock-out mice is accompanied by age-dependent, region-specific alterations in brain amino acids, and monoamine turnover, which might be related to the reported synaptical and behavioural alterations in these animals.

INEL BNCT Program: Volume 5, No. 9. Bulletin, September 1991

Energy Technology Data Exchange (ETDEWEB)

Ackermann, A.L. [ed.

1991-12-31

This Bulletin presents a summary of accomplishments and highlights of the Idaho National Engineering Laboratory`s (INEL) Boron Neutron Capture Therapy (BNCT) Program for September 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.

Children of Working Mothers. Special Labor Force Report. Bulletin 2158.

Science.gov (United States)

Bureau of Labor Statistics (DOL), Washington, DC.

Part of a Special Labor Force Report series, this bulletin on children of working mothers discusses the increase in the number of children with working mothers as of March 1981, and describes major reasons for this growth. The bulletin consists of an article first published February 1982 in the "Monthly Labor Review," additional tables providing…

EUDISED R & D Bulletin.

Science.gov (United States)

Council of Europe, Strasbourg (France). Documentation Center for Education in Europe.

The EUDISED project, which was started in 1968, is a computer-based network of national agencies dealing with the main fields of educational information. Listed in this bulletin for 1976 are on-going and completed projects in educational research and development reported from Austria, Finland, France, Federal Republic of Germany, Norway, Spain,…

International bulletin on atomic and molecular data for fusion. No. 14

International Nuclear Information System (INIS)

Katsonis, K.

1980-11-01

This bulletin deals with atomic and molecular data for fusion. A bibliography for the most recent data presented in the document is provided. The bulletin contains a list of references covering the year 1980 for all the publications on controlled fusion and plasma physics

International bulletin on atomic and molecular data for fusion. No. 20

International Nuclear Information System (INIS)

Katsonis, K.

1982-09-01

This bulletin deals with atomic and molecular data for fusion. A bibliography for the most recent data presented in the document is provided. The bulletin contains a list of references covering the year 1982 for all the publications on controlled thermonuclear fusion and plasma physics

Annual Bulletin of General Energy Statistics for Europe. V. 23, 1990

International Nuclear Information System (INIS)

1992-01-01

The purpose of the Bulletin is to provide basic data on the energy situation as a whole in European countries, Canada and the United States of America. This publication is purely statistical in character. As from the 1980 edition of the bulletin the scope of statistics comprises production of energy by form, overall energy balance sheets and deliveries of petroleum products for inland consumption. While less details are given for solid and gaseous fuels as sources of energy than in previous editions of the bulletin, more information is available for liquid fuels and nuclear, hydro- and geothermal energy

Publication of a double Weekly Bulletin over Easter

CERN Multimedia

2003-01-01

During the Easter period, the weeks of 21 and 28 April, there will be only one issue of the Weekly Bulletin (n°17-18/2003). Items for publication in this double issue should reach the Publication section or the Staff Association, as appropriate, before midday on Tuesday 15 April. There will therefore be no Bulletin distribution on Friday 25 April. Announcements for publication in the next issue (n°19/2003) should be sent on Tuesday 29 April by noon. Publications Section/ETT Tel. 79971

Market bulletin - July 1989

International Nuclear Information System (INIS)

1989-01-01

This bulletin deals with the brazilian electric power consumption in July 1989, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Market bulletin - February 1989

International Nuclear Information System (INIS)

1989-01-01

This bulletin deals with the brazilian electric power consumption in February 1989, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 40; Issue 1 ... I D S – V b g branches in accordance with the SERS results and humidity responses. ... Ni˘gde University, Graduate School Natural and Applied Sciences, Ni˘gde 51240, ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 38; Issue 3 .... (EDX) and UV–vis spectroscopy were used to study the chemical composition and optical .... Enhanced microactuation with magnetic field curing of magnetorheological ... Structure, morphology and corrosion resistance of Ni–Mo+PTh composite coatings.

NHTSA's Office of Defects Investigation (ODI) - Technical Service Bulletins System (TSBS) - Downloadable file

Data.gov (United States)

Department of Transportation — The Technical Service Bulletins data contains summaries of the Manufacturers' Technical Service Bulletins by single year, make and model. An optional item of Vehicle...

Health Profiles of Mosaic Versus Non-mosaic FMR1 Premutation Carrier Mothers of Children With Fragile X Syndrome

Directory of Open Access Journals (Sweden)

Marsha R. Mailick

2018-05-01

Full Text Available The FMR1 premutation is of increasing interest to the FXS community, as questions about a primary premutation phenotype warrant research attention. 100 FMR1 premutation carrier mothers (mean age = 58; 67–138 CGG repeats of adults with fragile X syndrome were studied with respect to their physical and mental health, motor, and neurocognitive characteristics. We explored the correlates of CGG repeat mosaicism in women with expanded alleles. Mothers provided buccal swabs from which DNA was extracted and the FMR1 CGG genotyping was performed (Amplidex Kit, Asuragen. Mothers were categorized into three groups: Group 1: premutation non-mosaic (n = 45; Group 2: premutation mosaic (n = 41, and Group 3: premutation/full mutation mosaic (n = 14. Group 2 mothers had at least two populations of cells with different allele sizes in the premutation range besides their major expanded allele. Group 3 mothers had a very small population of cells in the full mutation range (>200 CGGs in addition to one or multiple populations of cells with different allele sizes in the premutation range. Machine learning (random forest was used to identify symptoms and conditions that correctly classified mothers with respect to mosaicism; follow-up comparisons were made to characterize the three groups. In categorizing mosaicism, the random forest yielded significantly better classification than random classification, with overall area under the receiver operating characteristic curve (AUROC of 0.737. Among the most important symptoms and conditions that contributed to the classification were anxiety, menopause symptoms, executive functioning limitations, and difficulty walking several blocks, with the women who had full mutation mosaicism (Group 3 unexpectedly having better health. Although only 14 premutation carrier mothers in the present sample also had a small population of full mutation cells, their profile of comparatively better health, mental health, and executive

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 32; Issue 2. Issue front cover thumbnail. Volume 32, Issue 2. April 2009, pages 117-214. pp 117-123 Thin Films and Nanomatter. Microstructural characteristics and mechanical properties of magnetron sputtered nanocrystalline TiN films on glass substrate.

75 FR 69080 - Federal Travel Regulation (FTR)

Science.gov (United States)

2010-11-10

... Administration (GSA) has issued FTR Bulletin 11-02, updating the Fly America Act information on the GSA web site... GENERAL SERVICES ADMINISTRATION Federal Travel Regulation (FTR) Fly America Act; United States and... Governmentwide Policy, General Services Administration (GSA). [[Page 69081

International bulletin on atomic and molecular data for fusion. No. 9

International Nuclear Information System (INIS)

Katsonis, K.; Rumble, J. Jr.; Smith, F.J.

1979-07-01

This bulletin deals with atomic and molecular data for fusion. A bibliography for the most recent data presented in the document is provided. Work in progress is briefly reported. The bulletin contains a list of references covering the years 1978 and 1979 for all the publications on controlled fusion and plasma physics

International bulletin on atomic and molecular data for fusion. No. 15

International Nuclear Information System (INIS)

Katsonis, K.

1981-03-01

This bulletin deals with atomic and molecular data for fusion. A bibliography for the most recent data presented in the document is provided. Work in progress is briefly reported. The bulletin contains a list of references covering the years 1980 and 1981 for all the publications on controlled fusion and plasma physics

International bulletin on atomic and molecular data for fusion. No. 7

International Nuclear Information System (INIS)

Katsonis, K.; Smith, F.J.

1979-01-01

This bulletin deals with atomic and molecular data for fusion. A bibliography for the most recent data presented in the document is provided. Work in progress is briefly reported. The bulletin contains an extensive list of references covering the years 1977 and 1978 for all the publications on control fusion and plasma physics

International bulletin on atomic and molecular data for fusion. No. 19

International Nuclear Information System (INIS)

Katsonis, K.

1982-06-01

This bulletin deals with atomic and molecular data for fusion. A bibliography for the most recent data presented in the document is provided. Work in progress is briefly reported. The bulletin contains a list of references covering the years 1981 and 1982 for all the publications on controlled fusion and plasma physics

r ben hassine - Bulletin of Materials Science | Indian Academy of ...

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. R BEN HASSINE. Articles written in Bulletin of Materials Science. Volume 40 Issue 1 February 2017 pp 79-85. Effect of Co substitution on the physicochemical properties of La 0.67 Sr 0.22 Ba 0.11 Mn 1 − x Co x O 3 compounds ( 0 ≤ x ≤ 0.3 ) · W CHERIF R BEN HASSINE J A ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 33; Issue 2 ... films deposited by rf magnetron sputtering using a high quality ceramic target ... Critical shear stress produced by interaction of edge dislocation with nanoscale inhomogeneity ... production cost limiting zircon usage as a raw material at an industrial scale.

Proyecto Leer Bulletin, Number 11.

Science.gov (United States)

Tome, Martha V., Ed.

Educational materials for students of Spanish and the Spanish speaking are listed in this bulletin. A general information section lists reference materials on bilingual children, the blind and physically handicapped, comics, consumer education, employment, health, heritage of the Spanish speaking, Mexican American biography, Mexican American film…

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 27; Issue 4. Issue front cover thumbnail. Volume 27, Issue 4. August 2004, pages 323-394. pp 323-325 Crystal Growth. Growth features of ammonium hydrogen -tartrate single crystals · G Sajeevkumar R Raveendran B S Remadevi Alexander Varghese Vaidyan.

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 25; Issue 4 ... were synthesized by self-propagating high temperature synthesis (SHS) method. ... Structure determination at room temperature and phase transition studies above T c in .... Hyperfine field distributions in disordered Mn2CoSn and Mn2NiSn Heusler alloys.

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 26; Issue 5. Issue front cover thumbnail. Volume 26, Issue 5. August 2003, pages 461-568. pp 461-464 Sensor Materials. Preparation, characterization and dielectric behaviour of some yttrium doped strontium stannates · P K Bajpai Kuldeep Ratre Mukul Pastor T P ...

Proyecto Leer Bulletin, Number 9.

Science.gov (United States)

Benson, Susan Shattuck

This bulletin lists addresses of publishers and distributors of audiovisual instructional materials in Spanish in the United States and Latin America. Sources are listed in four categories: (1) federal sources of materials, information on materials, names of resource people, programs, and proposal guidelines concerning the Spanish speaking; (2)…

WEEKLY BULLETIN : WE ARE INTERESTED IN YOUR OPINION !

CERN Multimedia

2002-01-01

The Weekly Bulletin publication team has prepared a questionnaire that finally allows you to say all you think, good or bad, about CERN's in-house journal. The aim of this survey is to improve the Bulletin and make it more readable and more practical. In short, we want it to be more useful to you! We will be publishing the results of this survey in a few weeks' time. Between now and then we invite you to fill out the web form, or the form just before the last page of this issue. Just 5 minutes of your time!

International bulletin on atomic and molecular data for fusion. No. 22

International Nuclear Information System (INIS)

Katsonis, K.

1983-05-01

This bulletin deals with atomic and molecular data for fusion. Work in progress is briefly reported (charge exchange of slow ionized ions with neutral gases, cross section for electron impact ionization of Alt). The bulletin contains a list of references covering the years 1981, 1982 and 1983 for publications on controlled thermonuclear fusion and plasma physics

International bulletin on atomic and molecular data for fusion. No. 8

International Nuclear Information System (INIS)

Katsonis, K.; Smith, F.J.

1979-04-01

This bulletin deals with atomic and molecular data for fusion. A bibliography for the most recent data presented in the document is provided. Work in progress is briefly reported. The bulletin contains an extensive list of references covering the year 1978 and the beginning of 1979 for all the publications on control fusion and plasma physics

Everything you always wanted to say about the Bulletin...

CERN Multimedia

2002-01-01

How would you describe the Weekly Bulletin? Excellent, fascinating? It's become your bedtime reading but you're afraid to admit it? Or perhaps you find it confused, 'too politically correct', totally unreadable? Or perhaps your view is somewhere in between the two? Whatever you think, WE ARE INTERESTED IN YOUR OPINION! And now's the time to express it. The publications team has prepared a questionnaire that will finally allow you to say all you think about CERN's in-house journal. The aim of this survey is to improve the Bulletin and make it more useful to you! We would also like to hear your views on the new electronic version. Last but not least we hope to change the way the Bulletin is distributed and thereby save paper. We will be publishing the results of this survey in a few weeks' time. Between now and then we invite you to fill out the Web form.Just 5 minutes of your time!

Publication of the bulletin in 2009

CERN Document Server

DG Unit

2009-01-01

The table below lists the 2009 publication dates for the paper version of the Bulletin and the corresponding deadlines for the submission of announcements. Please note that all announcements must be submitted by 12.00 midday on Tuesdays at the latest. Bulletin No. Week number Submission of announcements (before 12.00 midday) Publication date 3-4 Tuesday 6 January Monday 12 January 5-6 Tuesday 20 January Monday 26 January 7-8 Tuesday 3 February Monday 9 February 9-10 Tuesday 17 February Monday 23 February 11-12 Tuesday 3 March Monday 9 March 13-14 Tuesday 17 March Monday 23 March 15-16-17 (Easter issue) Tuesday 31 March Monday 6 April 18-19 Tuesday 21 April Monday 27 April 20-21 Tuesday 5 May Monday 11 May 22-23 Tuesday 19 May Monday 25 May 24-25 ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 40; Issue 5. Structural, microstructural and optical properties of Cu 2 ZnSnS 4 thin films prepared by thermal evaporation: effect of substrate temperature and annealing. U CHALAPATHI S UTHANNA V SUNDARA RAJA. Volume 40 Issue 5 September 2017 pp 887-895 ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 5. Effects of size on mass density and its influence on mechanical and thermal properties of ZrO 2 nanoparticles in different structures. BOTAN JAWDAT ABDULLAH QING JIANG MUSTAFA SAEED OMAR. Volume 39 Issue 5 September 2016 pp 1295-1302 ...

Engineering Manpower Bulletin, Number 16.

Science.gov (United States)

Engineers Joint Council, New York, NY. Engineering Manpower Commission.

This bulletin presents the highlights of an evaluation of today's engineering graduates as seen by the managers of engineering, manufacturing and technical marketing in a major electrical equipment manufacturing company. Today's engineer is seen as far more productive than his predecessor. The computer has greatly expanded his productive capacity.…

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 25; Issue 6. Issue front cover thumbnail. Volume 25, Issue 6. November 2002, pages 449-582. pp 449- .... Bi-layer functionally gradient thick film semiconducting methane sensors .... Thermal sensor properties of PANI(EB)–CSA ( = 0.4 ± 0.1 mol) polymer thin films.

Proyecto Leer Bulletin, Number 8.

Science.gov (United States)

Benson, Susan Shattuck

This bulletin lists educational materials for the Spanish speaking. Several hundred documents are listed in three main sections: (1) organizations, programs, laws, and news related to the Spanish speaking; (2) a list of books selected; and (3) a list of publishers and distributors with their addresses. Several bibliographies are included. Entries…

IDRC Bulletin — March 2017

International Development Research Centre (IDRC) Digital Library (Canada)

IDRC Bulletin — March 2017. Featured this month. Nighat Dad. Protecting digital rights in Pakistan. Nighat Dad is winning global accolades for her quest to protect women's safety on the Internet, while urging governments to balance cyber security with citizen rights. Find out how. News. Research for a climate-smart world.

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 29; Issue 1. Issue front cover thumbnail. Volume 29, Issue 1. February 2006, pages 1-99. pp 1-5 Nanomaterials. A simple synthesis and characterization of CuS nanocrystals · Ujjal K Gautam Bratindranath Mukherjee · More Details Abstract Fulltext PDF. Water-soluble ...

Male carriers of the FMR1 premutation show altered hippocampal-prefrontal function during memory encoding

Directory of Open Access Journals (Sweden)

John M Wang

2012-10-01

Full Text Available Previous functional MRI (fMRI studies have shown that fragile X mental retardation 1 (FMR1 premutation allele carriers (FXPCs exhibit decreased hippocampal activation during a recall task and lower inferior frontal activation during a working memory task compared to matched controls. The molecular characteristics of FXPCs includes 55 to 200 CGG trinucleoutide expansions, increased FMR1 mRNA levels, and decreased FMRP levels especially at higher repeat sizes. In the current study, we utilized MRI to examine differences in hippocampal volume and function during an encoding task in young male FXPCs. While no decreases in either hippocampal volume or hippocampal activity were observed during the encoding task in FXPCs, FMRP level (measured in blood correlated with decreases in parahippocampal activation. In addition, activity in the right dorsolateral prefrontal cortex during correctly encoded trials correlated negatively with mRNA levels. These results, as well as the established biological effects associated with elevated mRNA levels and decreased FMRP levels on dendritic maturation and axonal growth, prompted us to explore functional connectivity between the hippocampus, prefrontal cortex, and parahippocampal gyrus using a psychophysiological interaction analysis. In FXPCs, the right hippocampus evinced significantly lower connectivity with right ventrolateral prefrontal cortex (VLPFC and right parahippocampal gyrus. Furthermore, the weaker connectivity between the right hippocampus and VLPFC was associated with reduced FMRP in the FXPC group. These results suggest that while FXPCs show relatively typical brain response during encoding, faulty connectivity between frontal and hippocampal regions may have subsequent effects on recall and working memory.

2-Methyl-6-(phenylethynyl pyridine (MPEP reverses maze learning and PSD-95 deficits in Fmr1 knock-out mice.

Directory of Open Access Journals (Sweden)

Réno Michelle Gandhi

2014-03-01

Full Text Available Fragile X syndrome (FXS is caused by the lack of expression of the fragile X mental retardation protein (FMRP, which results in intellectual disability and other debilitating symptoms including impairment of visual-spatial functioning. FXS is the only single-gene disorder that is highly co-morbid with autism spectrum disorder and can therefore provide insight into its pathophysiology. Lack of FMRP results in altered group I metabotropic glutamate receptor (mGluR signalling, which is a target for putative treatments. The Hebb-Williams (H-W mazes are a set of increasingly complex spatial navigation problems that depend on intact hippocampal and thus mGluR-5 functioning. In the present investigation, we examined whether an antagonist of mGluR-5 would reverse previously described behavioural deficits in Fmr1 KO mice. Mice were trained on a subset of the H-W mazes and then treated with either 20 mg/kg of an mGluR-5 antagonist, 2-Methyl-6-(phenylethynyl pyridine (MPEP; n = 11 or an equivalent dose of saline (n = 11 prior to running test mazes. Latency and errors were dependent variables recorded during the test phase. Immediately after completing each test, marble-burying behavior was assessed which confirmed that the drug treatment was pharmacologically active during maze learning. Although latency was not statistically different between the groups, MPEP treated Fmr1 KO mice made significantly fewer errors on mazes deemed more difficult suggesting a reversal of the behavioural deficit. MPEP treated mice were also less perseverative and impulsive when navigating mazes. Furthermore, MPEP treatment reversed PSD-95 protein deficits in Fmr1 KO treated mice, whereas levels of a control protein (β-tubulin remained unchanged. These data further validate MPEP as a potentially beneficial treatment for FXS. Our findings also suggest that adapted H-W mazes may be a useful tool to document alterations in behavioural functioning following pharmacological

Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.

Directory of Open Access Journals (Sweden)

Cara J Westmark

Full Text Available Fragile X syndrome (FXS is the most common form of inherited intellectual disability and the leading known genetic cause of autism. Fragile X mental retardation protein (FMRP, which is absent or expressed at substantially reduced levels in FXS, binds to and controls the postsynaptic translation of amyloid β-protein precursor (AβPP mRNA. Cleavage of AβPP can produce β-amyloid (Aβ, a 39-43 amino acid peptide mis-expressed in Alzheimer's disease (AD and Down syndrome (DS. Aβ is over-expressed in the brain of Fmr1(KO mice, suggesting a pathogenic role in FXS. To determine if genetic reduction of AβPP/Aβ rescues characteristic FXS phenotypes, we assessed audiogenic seizures (AGS, anxiety, the ratio of mature versus immature dendritic spines and metabotropic glutamate receptor (mGluR-mediated long-term depression (LTD in Fmr1(KO mice after removal of one App allele. All of these phenotypes were partially or completely reverted to normal. Plasma Aβ(1-42 was significantly reduced in full-mutation FXS males compared to age-matched controls while cortical and hippocampal levels were somewhat increased, suggesting that Aβ is sequestered in the brain. Evolving therapies directed at reducing Aβ in AD may be applicable to FXS and Aβ may serve as a plasma-based biomarker to facilitate disease diagnosis or assess therapeutic efficacy.

International bulletin on atomic and molecular data for fusion. No. 16

International Nuclear Information System (INIS)

Katsonis, K.

1981-06-01

This bulletin deals with atomic and molecular data for fusion. A bibliography for the most recent data presented in the document is provided. Work in progress is briefly reported. ''Data Request'' in the fusion field are also mentioned. The bulletin contains a list of references covering the years 1980 and 1981 for all the publications on controlled fusion and plasma physics

A Female Patient with FMR1 Premutation and Mosaic X Chromosome Aneuploidy and Two Sons with Intellectual Disability.

Science.gov (United States)

Galanina, Ekaterina M; Tulupov, Andrey A; Lemskaya, Natalya A; Korostyshevskaya, Aleksandra M; Maksimova, Yuliya V; Shorina, Asia R; Savelov, Andrey A; Sergeeva, Irina G; Isanova, Evgeniya R; Grishchenko, Irina V; Yudkin, Dmitry V

2017-03-01

In this report, we describe a molecular cytogenetic study of a family burdened with intellectual disability (ID) and suicide. Our study revealed that the mother has a heterozygous premutation in the FMR1 gene and supernumerary X chromosomes as well as X-derived marker chromosomes. Both of her sons have ID and a normal chromosome number. One of the sons has fragile X syndrome, and the other has ID of an unclear nature.

Self-help on-line: an outcome evaluation of breast cancer bulletin boards.

Science.gov (United States)

Lieberman, Morton A; Goldstein, Benjamin A

2005-11-01

Many breast cancer patients find help from on-line self-help groups, consisting of self-directed, asynchronous, bulletin boards. These have yet to be empirically evaluated. Upon joining a group and 6 months later, new members (N=114) to breast cancer bulletin boards completed measures of depression (CES-D), growth (PTGI) and psychosocial wellbeing (FACT-B). Improvement was statistically significant on all three measures. This serves as a first validation of Internet bulletin boards as a source of support and help for breast cancer patients. These boards are of particular interest because they are free, accessible and support comes from peers and not from professional facilitators.

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

... Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Bulletin of Materials Science; Volume 36; Issue 6. Self-assembling behaviour of Pt nanoparticles onto surface of TiO2 and their resulting photocatalytic activity. M Qamar Ashok K Ganguli. Volume 36 Issue 6 November 2013 pp 945-951 ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 32; Issue 4. Issue front cover thumbnail. Volume 32, Issue 4. August 2009, pages 369-463. pp 369-373 Thin Films. Mobility activation in thermally deposited CdSe thin films · Kangkan Sarmah Ranjan Sarma · More Details Abstract Fulltext PDF. Effect of illumination on ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 23; Issue 5. Issue front cover thumbnail. Volume 23, Issue 5. October 2000, pages 341-452. pp 341-344 Synthesis. Preparation of Pt–Ru bimetallic catalyst supported on carbon nanotubes · B Rajesh K Ravindranathan Thampi J -M Bonard B Viswanathan · More Details ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 30; Issue 1. Issue front cover thumbnail. Volume 30, Issue 1. February 2007, pages 1-71. pp 1-3 Single Crystals. Thermoluminescence characteristics of Sm doped NaYF4 crystals · M V Ramana Reddy Ch Gopal Reddy K Narasimha Reddy · More Details Abstract ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 24; Issue 1. Issue front cover thumbnail. Volume 24, Issue 1. February 2001, pages 1-94. pp 1-21 Review---Phase Transitions. Kinetics of pressure induced structural phase transitions—A review · N V Chandra Shekar K Govinda Rajan · More Details Abstract Fulltext ...

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 23; Issue 3. Issue front cover thumbnail. Volume 23, Issue 3. June 2000, pages 159-238. pp 159-163 Nanomaterials. A note on the use of ellipsometry for studying the kinetics of formation of self-assembled monolayers · Murali Sastry · More Details Abstract Fulltext PDF.

29 CFR 2509.99-1 - Interpretive Bulletin Relating to Payroll Deduction IRAs.

Science.gov (United States)

2010-07-01

... 29 Labor 9 2010-07-01 2010-07-01 false Interpretive Bulletin Relating to Payroll Deduction IRAs... SECURITY ACT OF 1974 § 2509.99-1 Interpretive Bulletin Relating to Payroll Deduction IRAs. (a) Scope. This...), as applied to payroll deduction programs established by employers 1 for the purpose of enabling...

An infection control bulletin as an educational tool: is it useful?

Science.gov (United States)

Rea, L; Cronk, S; Conly, J

1992-01-01

For five years a bulletin has been issued to provide information, increase awareness and educate staff on current issues and problems in infection control. To obtain readers' feedback on the value of receiving this one-page bulletin, an evaluation was conducted with the following objectives: to evaluate the content and structure in terms of relevant and current information; to evaluate the format; and to obtain information on frequency and suggested topics. Categories for response were: poor, fair, good and excellent. All respondees (67) rated the topics as good to excellent in the current and applicable category. The detail and clarity were rated as good/excellent by 59 of 67 (88%) and 59 of 67 (88%) of the respondees, respectively. The majority, 61 of 67 (91%), indicated the references were useful. The readability, organization and length were rated as good/excellent by 63 of 67 (94%), 62 of 67 (92.5%) and 65 of 67 (97%), respectively. All but one wished to remain on the mailing list. The results of this evaluation and the list of suggested topics for future bulletins support the conclusion that the infection control bulletin is a useful educational tool.

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 32; Issue 3. Issue front cover thumbnail. Volume 32, Issue 3. June 2009, pages 215-367. pp 215-215. Foreword · S B Krupanidhi H L Bhat · More Details Fulltext PDF. pp 217-225. Molecule-based magnets · J V Yakhmi · More Details Abstract Fulltext PDF.

Proyecto Leer Bulletin, Number 12.

Science.gov (United States)

Tome, Martha V., Ed.

This bulletin is designed to serve the Spanish-speaking population of the United States. This issue contains a list of popular magazines in Spanish for children and adults. Another section provides the names of comics for children. Titles to be found under "Publications in Series and Collections" are the popular type of romantic, western, or…

Annual bulletin of market 1990

International Nuclear Information System (INIS)

1990-01-01

This bulletin deals with the brazilian electric power consumption in 1990 containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C)

Annual bulletin of market 1989

International Nuclear Information System (INIS)

1989-01-01

This bulletin deals with the brazilian electric power consumption in 1989 containing data about the total consumption, the growth rates, the special tariffs, and the monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C)

Do not miss the Announcements and Events sections of the Bulletin!

CERN Document Server

2013-01-01

There you'll find the availability of Services during the annual closure, the closure of the telephone switchboard, the Bulletin publication schedule for 2014, a pilot eduroam service at CERN, HSE Safety Bulletin 2013-4, new Swiss traffic rules, information about the infirmary's closure, the start of Horizon 2020, information on the CERN car stickers 2014... this information is FOR YOU!  

Bulletin #112 | CRDI - Centre de recherches pour le dévelopement ...

International Development Research Centre (IDRC) Digital Library (Canada)

Dans ce numéro, apprenez-en davantage sur la recherche du CRDI sur les acquisitions de terres à grande échelle en Afrique et le rôle clé du Centre dans un panel des Nations Unies sur l'autonomisation des femmes. De plus, lisez le dernier billet du blogue Sur les traces du changement. Logo du Bulletin du CRDI Bulletin ...

76 FR 13617 - Office of Federal High-Performance Green Buildings (OFHPGB); Notice of GSA Bulletin OFHPGB 2011...

Science.gov (United States)

2011-03-14

...-Performance Green Buildings (OFHPGB); Notice of GSA Bulletin OFHPGB 2011-OGP-1 AGENCY: Office of.... Procedures Bulletins regarding the Office of Federal High-Performance Green Building are located on the... Washington, DC 20405 OFFICE OF FEDERAL HIGH-PERFORMANCE GREEN BUILDINGS GSA Bulletin 2011-OGP-1 TO: Heads of...

78 FR 27242 - Updated Special Advisory Bulletin on the Effect of Exclusion From Participation in Federal Health...

Science.gov (United States)

2013-05-09

...] Updated Special Advisory Bulletin on the Effect of Exclusion From Participation in Federal Health Care... release of an updated Special Advisory Bulletin on the effect of exclusion from participation in Federal health care programs by OIG. The updated Special Advisory Bulletin describes the scope and effect of the...

Electronic bulletin board. OCRWM INFOLINK. Revision

International Nuclear Information System (INIS)

1986-04-01

This user's manual provides instructions for access to OCRWM INFOLINK (an electronic bulletin board). INFOLINK provides current program information and access to texts of: press releases; fact sheets/backgrounders; comgressional questions and answers; congressional testimony; speeches; schedules (milestones, meetings, and activities); and miscellaneous announcements

Bulletin of Materials Science | News

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 25; Issue 3 ... Sintering of nano crystalline silicon carbide by doping with boron carbide ... of these powders was achieved by addition of boron carbide of 0.5 wt% together with carbon of 1 wt% at 2050°C at vacuum (3 mbar) for 15 min. ... pp 213-217 Alloys and Steels.

Annual market and own load bulletin - 1992

International Nuclear Information System (INIS)

1993-01-01

This bulletin makes the market analysis for electric energy in Brazil in 1992, presenting data about energy consumption in each Brazilian region and the prices of electric power and petroleum products. (M.V.M.)

Play and Self-Regulation: Lessons from Vygotsky

Science.gov (United States)

Bodrova, Elena; Germeroth, Carrie; Leong, Deborah J.

2013-01-01

The authors consider the analysis of the literature on play research by Lillard and others in the January 2013 "Psychological Bulletin," an analysis that questioned the prevailing assumption of a causal relationship between play and child development, especially in the areas of creativity, reasoning, executive function, and regulation of…

Notice on the launch of the “Bulletin of International Environmental HorticultureStudies"

OpenAIRE

Yoritaka Tashiro

2011-01-01

This article refers to the purpose and technical procedure of the publication of the Bulletin of InternationalHorticulture Studies. This bulletin was endorsed by the universities and research organizations which are under thepower of academic exchange agreement with Chiba University. The publication shall be started in the next fiscalyear.

Family Violence & Sexual Assault Bulletin, 1996.

Science.gov (United States)

Geffner, Robert, Ed.

These two Bulletins contain selected articles that highlight research and treatment issues in child abuse and child sexual abuse. The first issue includes the following featured articles: (1) "The Relationships between Animal Abuse and Other Forms of Family Violence" (Phil Arkow), which addresses animal cruelty as a harbinger of…

49 CFR 579.5 - Notices, bulletins, customer satisfaction campaigns, consumer advisories, and other communications.

Science.gov (United States)

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Notices, bulletins, customer satisfaction... General § 579.5 Notices, bulletins, customer satisfaction campaigns, consumer advisories, and other... to NHTSA a copy of each communication relating to a customer satisfaction campaign, consumer advisory...

Fukushima-Daiichi accident. News bulletin no. 1 from April 6

International Nuclear Information System (INIS)

2011-01-01

This news bulletin has been prepared by the French institute of radiation protection and nuclear safety (IRSN) for the information of French residents in Japan. It presents, first, the situation at the date of the bulletin of the reactors at the power plant site, the accident management actions in progress, the radioactive contamination around the site and the meteorological forecasts. Then, it gives some general recommendations to residents concerning food consumption and dwelling hygiene. Finally, some scientific information about radionuclides migration, radioactive pollution and their environmental impact are given. (J.S.)

Credit Cards. Bulletin No. 721. (Revised.)

Science.gov (United States)

Fox, Linda Kirk

This cooperative extension bulletin provides basic information about credit cards and their use. It covers the following topics: types of credit cards (revolving credit, travel and entertainment, and debit); factors to consider when evaluating a credit card (interest rates, grace period, and annual membership fee); other credit card costs (late…

Bulletin Boards: The Great Corkboard Wasteland.

Science.gov (United States)

Reith, James W.

1970-01-01

A successful classroom bulletin board display should not only be decorative, but also must have clear-cut purposes and functions: informational (i.e., post current school news), instructional (i.e., expand on classroom units), and motivational (i.e., tap subliminal awareness). Some suggested techniques include (1) using space other than the…

A double Weekly Bulletin over Easter

CERN Multimedia

2004-01-01

During the Easter period, the weeks of 12 and 19 April, there will be only one issue of the Weekly Bulletin (no. 16-17/2004). Announcements for publication in the next issue (no. 18/2004) should be sent on Tuesday 20 April midday at the latest. Publication Section Tel. 79971

Virtual Issue #1: Oil Spill Research in the Bulletin of Environmental Contamination and Toxicology

Science.gov (United States)

The Bulletin of Environmental Contamination and Toxicology has been a venue for publishing oil spill research for over forty years. Rehwoldt et al. (1974) published the first oil spill focused paper in the Bulletin, reporting on the aquatic toxicity of two spill mitigating agents...

International bulletin on atomic and molecular data for fusion. No. 11

International Nuclear Information System (INIS)

Katsonis, K.; Rumble, J. Jr.

1980-01-01

This bulletin deals with atomic and molecular data for fusion. A bibliography for the most recent data presented in the document is provided. Work in progress is briefly reported. The bulletin contains a list of references the publications on controlled fusion and plasma physics for 1979. It contains an index to the contributed papers presented at the 11th International Conference on the Physics of Electronics and Atomic Collision (ICPEAC) held in Kyoto (Japan) in summer 1979

78 FR 27968 - Federal Management Regulation; Redesignations of Federal Buildings

Science.gov (United States)

2013-05-13

... Management Regulation; Redesignations of Federal Buildings AGENCY: Public Buildings Service (PBS), General... designation and redesignation of six Federal buildings. DATES: Expiration Date: This bulletin announcement expires July 30, 2013. The building designations and redesignations remains in effect until canceled or...

Nuclear medicine. Czech special bulletin. No. 2

International Nuclear Information System (INIS)

1991-09-01

The bulletin contains the article on the first experience with the CERTEC preparation in examination of brain perfusion and the article on the potential for the development and manufacture of radiopharmaceutical kits. Both articles are inputted into INIS. (J.B.)

Closeout of IE Bulletin 80-15: Possible loss of Emergency Notification System (ENS) with loss of offsite power

International Nuclear Information System (INIS)

Foley, W.J.; Dean, R.S.; Hennick, A.

1990-12-01

Documentation is provided in this report for the closeout of IE Bulletin 80-15 for nuclear power reactors. This bulletin pertained to a possible loss of the Emergency Notification System (ENS) upon loss of offsite power. Closeout is based on the implementation and verification of six (6) required actions by licensees of nuclear power reactors in operation or near to receiving an operating license when the bulletin was issued on June 18, 1980. Evaluation of utility responses and NRC/Region inspection reports indicates that the bulletin is closed for all of the 69 nuclear power reactors to which it was issued for action and which were not shut down indefinitely or permanently at the time of issuance of this report. Background information is supplied in the Introduction and Appendix A. Nuclear fuel facilities as well as nuclear power facilities were identified in the enclosures to the bulletin. However, per an NRC memorandum, the closeout of the bulletin for nuclear fuel facilities is not within the scope of this report

Bulletin 2005-12 : revised Alberta pipeline regulation issued

Energy Technology Data Exchange (ETDEWEB)

NONE

2005-05-31

A revised Pipeline Regulation has been issued and is currently available on the Alberta Energy and Utilities Board (EUB) website. Changes to the regulation reflect bothchanges in EUB regulatory policy and processes and technological improvements. Goals of the revision include improvements in overall pipeline performance, and the implementation of recommendations derived from the Public Safety and Sour Gas Committee concerning sour gas pipeline safety. The regulation was re-organized for greater clarity, and structured into 11 parts. Issues concerning the transition to the revised regulation were presented. The summary of notable administrative changes included clarifications of when a pipeline application is not required; when ABSA approval is required for steam lines; situations for which low-pressure natural gas lines must be licensed; and emergency response requirements. Technical clarifications include requirements for pipeline operations and maintenance manuals; composite materials; limitations on amounts of H{sub 2}S in polymeric pipe; pressure mismatches; approval for testing with gaseous media; venting of small volumes of raw gas; right-of-way surveillance; inspection of surface construction activities; annual corrosion evaluations; registering of pipelines and excavators in controlled areas with Alberta One-Call; ground disturbance training; restoration and signage maintenance on abandoned pipelines; sour service steel pipelines; unused pipelines and abandoned pipelines; and remediation of stub ends in operating pipelines.

Bulletin of the Chemical Society of Ethiopia: Submissions

African Journals Online (AJOL)

Journal Home > About the Journal > Bulletin of the Chemical Society of Ethiopia: Submissions ... All classes of manuscripts must represent substantial original work and must not ... Each reference should be given a separate reference number.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 7 ... pulse electrodeposition with ultrasound agitation from nickelWatts-type bath. ... The results showed that wear resistance increased with increase in duty cycle and frequency.

The unique contribution of the IDC Reviewed Event Bulletin to global seismicity catalogues

Science.gov (United States)

Koch, Karl; Kebede, Fekadu

2010-05-01

For monitoring the Comprehensive Nuclear-Test-Ban Treaty (CTBT) the International Monitoring System (IMS) network is currently being established that will eventually consists of 241 seismic, hydroacoustic and infrasound stations. The final result of processing and analysis of seismological and other waveform technology data from these stations is the Reviewed Event Bulletin (REB), which has been issued by the International Data Center (IDC) under provisional operation since February 2000 on a daily basis, except for a total of 28 days. The nearly 300,000 events produced since then correspond to more than 25,000 events per year. As an accompanying effort to the bulletin production at the IDC, quality assurance work has been carried out for the REB for the years from 2000 to 2008 through comparisons to similar bulletins of global seismicity, issued by the ISC and the National Earthquake Information Center (NEIC) of the United States Geological Survey. The comparisons with the NEIC bulletin concentrate on a timely identification of larger events that were either missed during interactive analysis at the IDC or which have been significantly mislocated. For the scope of this study the comparisons with the ISC bulletin are the focus, as this bulletin provides the most complete reference to global seismicity, even though it becomes available only after about two years of event occurrence. In our quality assessments we aimed at evaluating the consistency of event locations for common events, i.e. found in both the REB and the ISC bulletin having been relocated by ISC; the degree and the geospatial location of the events only produced in the REB and verified not being bogus, and those ISC relocated events not contained in the REB and which were missed during IDC analysis. Even though the seismic component of the IMS network with its maximum 170 seismometer stations is a sparse teleseismic network, locations differences of less than 1° (0.5° ) are observed, on average, for

Bulletins Aperçu sur l'adaptation : enseignements tirés de la ...

International Development Research Centre (IDRC) Digital Library (Canada)

21 avr. 2016 ... Les bulletins Aperçu sur l'adaptation sont neuf études de cas issues de sept projets soutenus par le programme Adaptation aux changements climatiques en Afrique. Chaque bulletin présente les enseignements tirés de travaux de recherche exécutés avec la participation active de collectivités menacées ...

Closeout of IE Bulletin 79-12: short-period scrams at boiling-water reactors. Final report

International Nuclear Information System (INIS)

DeBevac, C.J.; Holland, R.A.

1985-03-01

IE Circular 77-07 was issued on April 14, 1977 because of the occurrence of short period scram events at Dresden Unit 2 on December 28, 1976 and at Monticello on February 23, 1977. The circular advised BWR plants to revise their control rod withdrawal sequences and operating procedures to reduce the likelihood of future short period scrams. However, similar events continued to occur. These included events at Oyster Creek on December 14, 1978; at Browns Ferry Unit 1 on January 18, 1979; and at Hatch Unit 1 on January 31, 1979. As a result of these events, IE Bulletin 79-12 was issued on May 31, 1979. This bulletin required a written response from licensees of GE-designed BWRs regarding specific actions listed in the bulletin. All of the licensees responded in a satisfactory manner. No similar events have been reported since IE Bulletin 79-12 was issued

International bulletin on atomic and molecular data for fusion. No. 17

International Nuclear Information System (INIS)

Katsonis, K.; Langley, R.A.

1981-11-01

This bulletin deals with atomic and molecular data for fusion. A bibliography for the most recent data presented in the document is provided. Work in progress is briefly reported: Electron ionization cross sections for light elements, single electron capture by highly charged ions colliding with hydrogen, inconel 626 surface exfoliation, cavities in nickel induced by helium ion irradiation, electron impact excitation of hydrogenic ions. The bulletin contains a list of references for the publications on controlled fusion and plasma physics for 1980 and 1981

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 34; Issue 4 ... has a dielectric anomaly of ferroelectric to paraelectric type at 198°C, and exhibits ... that the compound has negative temperature coefficient of resistance (NTCR) behaviour.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

The Bulletin of Materials Science began in the year 1979. ... one of the world's leading interactive databases of high quality STM journals, book series, books, reference works and online archives collection. ... Sadashivanagar, P.B. No. 8005 ...

Closeout of IE Bulletin 84-02: Failures of General Electric Type HFA relays in use in Class 1E safety systems

International Nuclear Information System (INIS)

Foley, W.J.; Dean, R.S.; Hennick, A.

1991-01-01

Documentation is provided in this report to close IE Bulletin 84--02 regarding the failure of General Electric Type HFA relays in Class 1E safety systems. The relay failures were due to aging of coil wire insulation and nylon or Lexan spools under certain environmental conditions. The bulletin was issued to nuclear power reactor licensees and holders of construction permits to provide assurance that the manufacturer's recommendations for corrective actions would be implemented. The bulletin required four specific actions, plus a review of the general concerns of the bulletin even though some facilities had different relays from those of bulletin concern. Evaluation of utility responses, NRC/Region inspection reports, and regional telephone calls has resulted in bulletin closeout of 116 (98%) of the 118 facilities to which the bulletin was issued for action. Facilities which were shut down or had construction halted indefinitely or permanently when the report was issued are not included in this review. A follow-up item is proposed in Appendix C for the two facilities with open status. Background information is supplied in the Introduction and Appendix A

Publication of a double weekly bulletin for Jeûne Genevois

CERN Multimedia

2001-01-01

A double issue of the Weekly Bulletin (nos 36-37/2001) will cover events at CERN from 3 September to 14 September 2001. Items for publication in this double edition should reach the Publications Section or the Staff Association, as appropriate, before midday on Tuesday 28 August. There will therefore be no Bulletin distribution on Friday 7 September. Announcements for publication in the next issue (no 38/2001) should reach the Publication Section or the Staff Association, as appropriate, on Tuesday 11 September by noon. Publications Section/ ETT Tel. 73830

1989 OCRWM [Office of Civilian Radioactive Waste Management] Bulletin compilation and index

International Nuclear Information System (INIS)

1990-02-01

The OCRWM Bulletin is published by the Department of Energy, Office of Civilian Radioactive Waste Management to provide current information about the national program for managing spent fuel and high-level radioactive waste. This document is a compilation of issues from the 1989 calendar year. A table of contents and one index have been provided to assist in finding information contained in this year's Bulletins. The pages have been numbered consecutively at the bottom for easy reference. 7 figs

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 33; Issue 1. Structure, optical and thermal decomposition characters of LDPE graft copolymers synthesized by gamma irradiation ... Keywords. Gamma irradiation; graft copolymerization; spectroscopic analysis; XRD; kinetics of thermal decomposition; activation energy.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 40; Issue 4 ... Nacional de Investigaciones Científicas y Técnicas), A4408FVY Salta, Argentina; Fac. Ingeniería, Universidad Nacional de Salta, A4408FVY Salta, Argentina; Fac.

A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome.

Directory of Open Access Journals (Sweden)

Ahmad M Khalil

2008-01-01

Full Text Available Several genome-wide transcriptomics efforts have shown that a large percentage of the mammalian genome is transcribed into RNAs, however, only a small percentage (1-2% of these RNAs is translated into proteins. Currently there is an intense interest in characterizing the function of the different classes of noncoding RNAs and their relevance to human disease. Using genomic approaches we discovered FMR4, a primate-specific noncoding RNA transcript (2.4 kb that resides upstream and likely shares a bidirectional promoter with FMR1. FMR4 is a product of RNA polymerase II and has a similar half-life to FMR1. The CGG expansion in the 5' UTR of FMR1 appears to affect transcription in both directions as we found FMR4, similar to FMR1, to be silenced in fragile X patients and up-regulated in premutation carriers. Knockdown of FMR4 by several siRNAs did not affect FMR1 expression, nor vice versa, suggesting that FMR4 is not a direct regulatory transcript for FMR1. However, FMR4 markedly affected human cell proliferation in vitro; siRNAs knockdown of FMR4 resulted in alterations in the cell cycle and increased apoptosis, while the overexpression of FMR4 caused an increase in cell proliferation. Collectively, our results demonstrate an antiapoptotic function of FMR4 and provide evidence that a well-studied genomic locus can show unexpected functional complexity. It cannot be excluded that altered FMR4 expression might contribute to aspects of the clinical presentation of fragile X syndrome and/or related disorders.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 38; Issue 4 ... The energy diagram shows the feasibility of La2CuO4 for the H2 evolution under visible light. ... Laboratory of Storage and Valorization of Renewable Energies, Faculty of ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 40; Issue 5. Optical spectroscopy of rare earth-doped oxyfluoro-tellurite glasses to probe local environment. GAJANAN V HONNAVAR K P RAMESH ... Keywords. Tellurite glasses; Raman spectroscopy; photoluminscence; Stark level splitting; UV visible spectroscopy.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Bulletin of Materials Science; Volume 29; Issue 2. Mechanism of cube grain nucleation during recrystallization of deformed commercial purity aluminium. K T Kashyap R George. Nucleation Studies Volume 29 Issue ... Keywords. Recrystallization; cube texture; commercial purity aluminium; differential stored energy model.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Articles written in Bulletin of Materials Science. Volume ... Preparation and characterization of magnesium–aluminium–silicate glass ceramics ... Preparation and studies of some thermal, mechanical and optical properties of .... Surface degradation behaviour of sodium borophosphate glass in aqueous media: Some studies.

Gap Analysis Bulletin No. 13

Science.gov (United States)

2005-12-01

we would like to web developer; gather comments from GAP researchers and data users. We are * facilitate collaboration among GAP projects by...N.Y. Research Grant #012/01 A. 42 Gap Analysis Bulletin No. 13, December 2005 Ga pAnalysis Smith, S. D., W. A. Brown, C. R. Smith, and M. E. Richmond... GAP will be focusing activities have greatly reduced the habitat available to support on the enduring features of the Great Lakes basin. Influences

Volcanology Section Bulletin. French Geologic Society; Bulletin de la Section de Volcanologie. Societe Geologique de France

Energy Technology Data Exchange (ETDEWEB)

Boudon, G [I.P.G.P. - Observatoire Volcanologique, 75 - Paris (France); Gourgaud, A [Universite Blaise Pascal, 63 - Clermont Ferrand (France); Soler, E [Universite Paris 6, Paris (France)

1997-12-31

This issue of the Volcanology Section Bulletin is a compilation of abstracts from the meeting the section of April, 2 1996 about the active volcanism of Central America and Mexico. The abstracts selected in this issue report on measurements of uranium, thorium and radium isotopes disequilibrium in lava, and radon fluctuations in volcanic gases. One abstract reports on new {sup 14}C datings on avalanche debris. (J.S.).

Volcanology Section Bulletin. French Geologic Society; Bulletin de la Section de Volcanologie. Societe Geologique de France

Energy Technology Data Exchange (ETDEWEB)

Boudon, G. [I.P.G.P. - Observatoire Volcanologique, 75 - Paris (France); Gourgaud, A. [Universite Blaise Pascal, 63 - Clermont Ferrand (France); Soler, E. [Universite Paris 6, Paris (France)

1996-12-31

This issue of the Volcanology Section Bulletin is a compilation of abstracts from the meeting the section of April, 2 1996 about the active volcanism of Central America and Mexico. The abstracts selected in this issue report on measurements of uranium, thorium and radium isotopes disequilibrium in lava, and radon fluctuations in volcanic gases. One abstract reports on new {sup 14}C datings on avalanche debris. (J.S.).

Market and own load bulletin - May 1993

International Nuclear Information System (INIS)

1993-01-01

This bulletin shows the Brazilian electric power consumption in May 1993, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each Brazilian region. The economic indexes of industrial production, the market, the prices of electric power and petroleum products are also presented. (M.V.M.)

Market and own load bulletin - January 1993

International Nuclear Information System (INIS)

1993-01-01

This bulletin shows the Brazilian electric power consumption in January 1993, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each Brazilian region. The economic indexes of industrial production, the market, the prices of electric power and petroleum products are also presented. (M.V.M.)

Market and own load bulletin - February 1993

International Nuclear Information System (INIS)

1993-01-01

This bulletin shows the Brazilian electric power consumption in February 1993, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each Brazilian region. The economic indexes of industrial production, the market, the prices of electric power and petroleum products are also presented. (M.V.M.)

Market and own load bulletin - March 1993

International Nuclear Information System (INIS)

1993-01-01

This bulletin shows the Brazilian electric power consumption in March 1993, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each Brazilian region. The economic indexes of industrial production, the market, the prices of electric power and petroleum products are also presented. (M.V.M.)

Market and own load bulletin - November 1992

International Nuclear Information System (INIS)

1992-01-01

This bulletin shows the Brazilian electric power consumption in November 1993, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each Brazilian region. The economic indexes of industrial production, the market, the prices of electric power and petroleum products are also presented. (M.V.M.)

76 FR 17191 - Staff Accounting Bulletin No. 114

Science.gov (United States)

2011-03-28

... statements and those prescribing disclosures that explain, modify or supplement the accounting measurements... which material revenues or expenses are recorded; and Significant accounting policies and measurement... Staff Accounting Bulletin No. 114; Rule #0;#0;Federal Register / Vol. 76 , No. 59 / Monday, March 28...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 33; Issue 1. Dispersion and reinforcing mechanism of carbon nanotubes in epoxy nanocomposites. Smrutisikha Bal ... Author Affiliations. Smrutisikha Bal1. Department of Metallurgical and Materials Engineering, National Institute of Technology, Rourkela 769 008, India ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 29; Issue 5 ... Polyester urethane; scaffold; tensile strength; swelling; degradation; cell culture. ... Materials Science Centre, Indian Institute of Technology, Kharagpur 721 302, India; School of Medical Science and Technology, Indian Institute of Technology, Kharagpur ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 2. Efficiency of surface modified Ti coated with copper nanoparticles to control marine bacterial adhesion under laboratory simulated conditions. CHOKKALINGAM PRIYA GANESSIN ARAVIND WILSON RICHARD THILAGARAJ. Volume 39 Issue 2 April 2016 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 30; Issue 4 ... Microwave materials; ceramic dielectric resonators; polytitanates; co-precipitation. ... hypotheses viz. diffusion, high surface and nucleation energy, potential barrier, non-stoichiometry etc as critical factors limiting formation of 2 : 9 as single-phase material.

Fukushima-Dai-Ichi accident. Information bulletin no. 8 from December 12, 2011; Accident de Fukushima-Dai-Ichi - Bulletin d'information no. 8 du 12 decembre 2011

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-12-12

This news bulletin has been prepared by the French institute of radiation protection and nuclear safety (IRSN) for the information of French residents in Japan. It presents, first, the situation at the date of the bulletin of the food chain contamination in the provinces close to the Fukushima Dai-ichi damaged site, the particular case of rice contamination monitoring and the controls performed at retailer shops. Then, it gives some general recommendations to residents concerning good food consumption and hygiene practices and recommends to avoid any unnecessary travel to the most impacted areas close to the prohibited access area. (J.S.)

Fukushima-Daiichi accident. News bulletin no. 3 from April 13

International Nuclear Information System (INIS)

2011-01-01

This news bulletin has been prepared by the French institute of radiation protection and nuclear safety (IRSN) for the information of French residents in Japan. It presents, first, the situation at the date of the bulletin of the reactors at the power plant site, the accident management actions in progress, the radioactive contamination around the site, the evolution of radioactivity in the air of Tokyo since March 15, the meteorological forecasts, and the impact of the April 7 earthquake. Then, it gives some general recommendations to residents concerning food consumption and dwelling hygiene. Finally, some scientific information about radionuclides migration, radioactive pollution and their environmental impact are given. The kinetics of plants contamination is explained. (J.S.)

Market bulletin and own load - October 1991

International Nuclear Information System (INIS)

1991-01-01

This bulletin deals with the brazilian electric power consumption in October 1991, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Market bulletin and own load - June 1992

International Nuclear Information System (INIS)

1992-01-01

This bulletin deals with the brazilian electric power consumption in June 1992, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Market bulletin and own load - April 1992

International Nuclear Information System (INIS)

1992-01-01

This bulletin deals with the brazilian electric power consumption in April 1992, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Market bulletin and own load - September 1992

International Nuclear Information System (INIS)

1992-01-01

This bulletin deals with the brazilian electric power consumption in September 1992, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Market bulletin and own load - August 1992

International Nuclear Information System (INIS)

1992-01-01

This bulletin deals with the brazilian electric power consumption in August 1992, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Market bulletin and own load - September 1991

International Nuclear Information System (INIS)

1991-01-01

This bulletin deals with the brazilian electric power consumption in September 1991, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Market bulletin and own load - March 1992

International Nuclear Information System (INIS)

1992-01-01

This bulletin deals with the brazilian electric power consumption in March 1992, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Market bulletin and own load - May 1992

International Nuclear Information System (INIS)

1992-01-01

This bulletin deals with the brazilian electric power consumption in May 1992, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 31; Issue 2. Studies on in vitro release of CPM from semi-interpenetrating polymer network (IPN) composed of chitosan and glutamic acid. K Kumari P P Kundu. Polymers Volume 31 Issue 2 April 2008 pp 159-167 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 31; Issue 4 .... Synthesis and structural studies of Na2O–ZnO–ZnF2–B2O3 oxyfluoride glasses ... processing: A potential technique for preparing NiO–YSZ composite and Ni–YSZ cermet.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 34; Issue 4. Preparation of titanium diboride powders from titanium alkoxide ... The influence of TTIP concentration, reaction temperature and molar ratio of precursors on the synthesis of titanium diboride was investigated. Three different concentrations of TTIP solution, ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 30; Issue 2 ... TSDC; PS; naphthalene; thermo-electrets; glass transition temperature (g). Abstract. The electrical conductivity of naphthalene doped polystyrene (PS) films (≈ 61.58 m thick) was studied as a function of dopant concentration and temperature.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 27; Issue 5 ... The electrical performances of thin film material can be improved largely by dopants. ... Department of Materials Science and Engineering, Jinan University, Jinan 250022, PR China; The State Key Laboratory of Material Composite and Advanced ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 38; Issue 7. Glassy carbon electrodes modified with gelatin functionalized reduced graphene oxide nanosheet for determination of gallic acid. Fereshteh Chekin Samira Bagheri Sharifah Bee Abd Hamid. Volume 38 Issue 7 December 2015 pp 1711-1716 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 33; Issue 4 ... Permittivity; polarization effects; strontium tartrate; thermal properties; dielectric properties. ... It is explained that crystallographic change due to polymorphic phase transition may be occurring in the material, besides the change due to loss of water ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Editorial Board. Bulletin of Materials Science. Editor. Giridhar U. Kulkarni, Centre for Nano and Soft Matter Science, Bengaluru. Associate Editors. Ayan Datta, Indian Association for the Cultivation of Science, Kolkata M. Eswaramoorthy, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru A.K. Ganguli ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 24; Issue 4. Evaluation of solid–liquid interface profile during continuous casting by a spline based formalism. S K Das. Metals and Alloys Volume ... Keywords. Continuous casting; solidification; solid–liquid interface; front tracking algorithm; phase change; heat transfer.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 3 ... The morphology and the nature of the protective layer grown under the paint film were also ... en Tecnología de Pinturas, Calle 52e/121 y 122, (B1900AYB), La Plata 1900, ...

ICFA Instrumentation Bulletin, Volume 23, Fall 2001 Issue (SLAC-J-ICFA-023)

Energy Technology Data Exchange (ETDEWEB)

Va' Vra, J.

2003-10-21

The publication of the ICFA Instrumentation Bulletin is an activity of the Panel on Future Innovation and Development of ICFA (International Committee for Future Accelerators). The Bulletin reports on research and progress in the field of instrumentation with emphasis on application in the field of high-energy physics. It encourages issues of generic instrumentation. This issue has the following articles: (1) ''A Large Area Timing RPC''; (2) ''Applications and New Developments in Resistive Plate Chambers''; and (3) ''Advanced Study of Silicon Photomultipliers''.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 31; Issue 3. Formation of InN nanoparticle and nanorod structures by nitrogen plasma annealing method ... Department of Physics, Indian Institute of Technology Delhi, New Delhi 110 016, India; Material Science Division, Indira Gandhi Centre for Atomic Research, ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 31; Issue 1. Pressure induced graft-co-polymerization of acrylonitrile onto Saccharum cilliare fibre and ... Author Affiliations. A S Singha1 Anjali Shama1 Vijay Kumar Thakur1. Material Science Laboratory, National Institute of Technology, Hamirpur 177 005, India ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 31; Issue 6 .... modified with 4–12% 3,3′-bis(maleimidophenyl) phenylphosphine oxide and cured ... Study of effect of composition, irradiation and quenching on ionic ... Application of magnetron sputtering for producing bioactive ceramic coatings on implant materials.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 33; Issue 2. Evaluation of borax solid wastes in production of frits suitable for fast single-fired wall tile opaque glass–ceramic glazes. K Pekkan B Karasu. Ceramics and Glasses Volume 33 Issue 2 April 2010 pp 135-144 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 35; Issue 3. Property change during nanosecond pulse laser annealing of amorphous NiTi thin film ... amorphous thin films of near equiatomic Ni/Ti composition to produce partially crystallized highly sensitive -phase spots surrounded by amorphous regions. Scanning ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Courses · Symposia · Live Streaming. Home; Journals; Bulletin of Materials Science; Volume 27; Issue 6. Temperature dependence of pulse-induced mechanoluminescence excitation in coloured alkali halide crystals. Namita Rajput S Tiwari B P Chandra. Optical Properties Volume 27 Issue 6 December 2004 pp 505-509 ...

IE Bulletin No. 79-01: Environmental qualification of Class IE equipment

International Nuclear Information System (INIS)

Anon.

1993-01-01

The intent of IE Circular 78-08 was to highlight to all licensees important lessons learned from environmental qualification deficiencies reported by individual licensees. In this regard, licensees were requested to examine installed safety-related electrical equipment and determine that proper documentation existed which provided assurance that this equipment would function under postulated accident conditions. The intent of this Bulletin is to raise the threshold of IE Circular 78-08 to the level of a Bulletin; i.e., action requiring a licensee response. Inspections conducted to date by the NRC of licensees' activities in response to IE Circular 78-08 have identified one component which licensees have found to be unqualified for service within the LOCA environment. Specifically, unqualified stem mounted limit switches (SMLS), other than those identified in previously issued IE Bulletin 78-04, were found to be installed on safety-related valves inside containment at both Duane Arnold and Quad Cities 1 and 2 Nuclear Generating Stations. According to the manufacturer, these switches are designed only for general purpose applications and are not considered suitable devices for service in the LOCA environment. Consequently, switches are being replaced at the above power plants with qualified components

Brazilian energy statistics - 1996. Annual bulletin of the Brazilian Committee of the World Energy Council

International Nuclear Information System (INIS)

1996-01-01

This bulletin deals with the primary sources that carry most weight in the Brazilian energy balance: hydroelectric energy, petroleum, natural gas and coal. It also contains data on ethyl alcohol derived of sugar cane since it is of special importance in Brazil's energy scenario. Domestic production, petroleum and petroleum product imports, as well as natural gas production statistics are furnished in this bulletin

Fukushima-Daiichi accident. News bulletin no. 2 from April 8

International Nuclear Information System (INIS)

2011-01-01

This news bulletin has been prepared by the French institute of radiation protection and nuclear safety (IRSN) for the information of French residents in Japan. It presents, first, the situation at the date of the bulletin of the reactors at the power plant site, the accident management actions in progress, the radioactive contamination around the site, the evolution of radioactivity in the air of Tokyo since March 15, the meteorological forecasts, and the impact of the April 7 earthquake. Then, it gives some general recommendations to residents concerning food consumption and dwelling hygiene. Finally, some scientific information about radionuclides migration, radioactive pollution and their environmental impact are given. The geographic distribution of radioactive fallouts around the Fukushima-Daiichi site is shown. (J.S.)

Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila

Directory of Open Access Journals (Sweden)

Samuel H. Friedman

2013-11-01

Fragile X syndrome (FXS, the most common inherited determinant of intellectual disability and autism spectrum disorders, is caused by loss of the fragile X mental retardation 1 (FMR1 gene product (FMRP, an mRNA-binding translational repressor. A number of conserved FMRP targets have been identified in the well-characterized Drosophila FXS disease model, but FMRP is highly pleiotropic in function and the full spectrum of FMRP targets has yet to be revealed. In this study, screens for upregulated neural proteins in Drosophila fmr1 (dfmr1 null mutants reveal strong elevation of two synaptic heparan sulfate proteoglycans (HSPGs: GPI-anchored glypican Dally-like protein (Dlp and transmembrane Syndecan (Sdc. Our recent work has shown that Dlp and Sdc act as co-receptors regulating extracellular ligands upstream of intracellular signal transduction in multiple trans-synaptic pathways that drive synaptogenesis. Consistently, dfmr1 null synapses exhibit altered WNT signaling, with changes in both Wingless (Wg ligand abundance and downstream Frizzled-2 (Fz2 receptor C-terminal nuclear import. Similarly, a parallel anterograde signaling ligand, Jelly belly (Jeb, and downstream ERK phosphorylation (dpERK are depressed at dfmr1 null synapses. In contrast, the retrograde BMP ligand Glass bottom boat (Gbb and downstream signaling via phosphorylation of the transcription factor MAD (pMAD seem not to be affected. To determine whether HSPG upregulation is causative for synaptogenic defects, HSPGs were genetically reduced to control levels in the dfmr1 null background. HSPG correction restored both (1 Wg and Jeb trans-synaptic signaling, and (2 synaptic architecture and transmission strength back to wild-type levels. Taken together, these data suggest that FMRP negatively regulates HSPG co-receptors controlling trans-synaptic signaling during synaptogenesis, and that loss of this regulation causes synaptic structure and function defects characterizing the FXS disease state.

OCRWM Bulletin: Westinghouse begins designing multi-purpose canister

International Nuclear Information System (INIS)

1995-01-01

This publication consists of two parts: OCRWM (Office of Civilian Radioactive Waste Management) Bulletin; and Of Mountains ampersand Science which has articles on the Yucca Mountain project. The OCRWM provides information about OCRWM activities and in this issue has articles on multi-purpose canister design, and transportation cask trailer

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 35; Issue 5. Effect of nitrogen flow ratio on structure and properties of zirconium nitride films on Si(100) prepared by ion beam sputtering. Shahab Norouzian Majid Mojtahedzadeh Larijani Reza Afzalzadeh. Volume 35 Issue 5 October 2012 pp 885-887 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 40; Issue 5. Electro-optical properties, decomposition pathways and the hydrostatic pressure-dependent behaviours of a double-cation hydrogen storage material of Al 3 Li 4 (BH 4 ) 13. MEHMET SIMSEK. Volume 40 Issue 5 September 2017 pp 907-915 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 40; Issue 3. Effect of composition on the polarization and ohmic resistances of LSM/YSZ composite cathodes in solid oxide fuel cell. B SHRI PRAKASH S SENTHIL KUMAR S T ARUNA. Volume 40 Issue 3 June 2017 pp 441-452 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 36; Issue 1. Characterization and in vitro and in vivo evaluation of cross-linked chitosan films as implant for controlled release of citalopram. Patit P Kundu Santosh Kumar Jindal Manish Goswami. Volume 36 Issue 1 February 2013 pp 175-182 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Articles written in Bulletin of Materials Science. Volume 29 Issue 2 April 2006 pp 101-105 Polymers. Proton microbeam irradiation effects on PtBA polymer ... optical and secondary electron microscopic experimental methods. Volume 34 Issue 4 July 2011 pp 595-599. Thermal stability of gold-PS nanocomposites thin films.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 28; Issue 2. Effect of annealing temperature on the structural–microstructural and electrical characteristics of thallium bearing HTSC films prepared by chemical spray pyrolysis technique. K K Verma R S Tiwari O N Srivastava. Superconductors Volume 28 Issue 2 April ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Special Issues. Bulletin of Materials Science. pp 199-584 Volume 31 Issue 3 June 2008. Proceedings of the 'National Review and Coordination Meeting on Nanoscience and Nanotechnology', Hyderabad, 2007. Editor: S. B. Krupanidhi Guest Editors: G. Sundararajan and Tata Narasinga Rao. pp 547-651 Volume 29 Issue ...

OCRWM Bulletin: Westinghouse begins designing multi-purpose canister

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-09-01

This publication consists of two parts: OCRWM (Office of Civilian Radioactive Waste Management) Bulletin; and Of Mountains & Science which has articles on the Yucca Mountain project. The OCRWM provides information about OCRWM activities and in this issue has articles on multi-purpose canister design, and transportation cask trailer.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Articles written in Bulletin of Materials Science. Volume 26 Issue 2 February 2003 pp 247-253 Electrical Properties. Impedance spectroscopy ... the a.c. conductivity data. Volume 26 Issue 7 December 2003 pp 745-747 Electrical Properties. Dielectric properties of piezoelectric 3–0 composites of lithium ferrite/barium titanate.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 23; Issue 6. Resistance to freezing and thawing of mortar specimens made from sulphoaluminate–belite cement ... Author Affiliations. I Janotka1 L' Krajèi1. Institute of Construction and Architecture of the Slovak Academy of Sciences, Bratislava, Slovak Republic ...

Contribution of Infrasound to IDC Reviewed Event Bulletin

Science.gov (United States)

Bittner, Paulina; Polich, Paul; Gore, Jane; Ali, Sherif Mohamed; Medinskaya, Tatiana; Mialle, Pierrick

2016-04-01

Until 2003 two waveform technologies, i.e. seismic and hydroacoustic were used to detect and locate events included in the International Data Centre (IDC) Reviewed Event Bulletin (REB). The first atmospheric event was published in the REB in 2003 but infrasound detections could not be used by the Global Association (GA) Software due to the unmanageable high number of spurious associations. Offline improvements of the automatic processing took place to reduce the number of false detections to a reasonable level. In February 2010 the infrasound technology was reintroduced to the IDC operations and has contributed to both automatic and reviewed IDC bulletins. The primary contribution of infrasound technology is to detect atmospheric events. These events may also be observed at seismic stations, which will significantly improve event location. Examples of REB events, which were detected by the International Monitoring System (IMS) infrasound network were fireballs (e.g. Bangkok fireball, 2015), volcanic eruptions (e.g. Calbuco, Chile 2015) and large surface explosions (e.g. Tjanjin, China 2015). Query blasts and large earthquakes belong to events primarily recorded at seismic stations of the IMS network but often detected at the infrasound stations. Presence of infrasound detection associated to an event from a mining area indicates a surface explosion. Satellite imaging and a database of active mines can be used to confirm the origin of such events. This presentation will summarize the contribution of 6 years of infrasound data to IDC bulletins and provide examples of events recorded at the IMS infrasound network. Results of this study may help to improve location of small events with observations on infrasound stations.

Juvenile Residential Facility Census, 2010: Selected Findings. Juvenile Offenders and Victims: National Report Series. Bulletin NCJ 241134

Science.gov (United States)

Hockenberry, Sarah; Sickmund, Melissa; Sladky, Anthony

2013-01-01

This bulletin is part of the "Juvenile Offenders and Victims National Report Series." The "National Report" offers a comprehensive statistical overview of the problems of juvenile crime, violence, and victimization and the response of the juvenile justice system. During each interim year, the bulletins in the "National…

76 FR 4115 - Request for the Technical Review of the Draft Current Intelligence Bulletin (CIB): Derivation of...

Science.gov (United States)

2011-01-24

... NIOSH-156] Request for the Technical Review of the Draft Current Intelligence Bulletin (CIB): Derivation... public review of the draft, Current Intelligence Bulletin (CIB): Derivation of Immediately Dangerous to... established and (3) an overview of the analysis applied by NIOSH to develop a scientifically-based approach...

A double Weekly Bulletin over Easter

CERN Multimedia

2004-01-01

During the Easter period, the weeks of 12 and 19 April, there will be only one issue of the Weekly Bulletin (no. 16-17/2004). Items for publication in this double issue should reach the Publication section or Staff Association, as appropriate, before midday on Tuesday 6 April. Announcements for publication in the next issue (no. 18/2004) should be sent on Tuesday 20 April midday at the latest. Publication Section Tel. 79971

Triterpenes from the resin of Boswellia neglecta | Dekebo | Bulletin ...

African Journals Online (AJOL)

Bulletin of the Chemical Society of Ethiopia. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 16, No 1 (2002) >. Log in or Register to get access to full text downloads.

Fukushima-Dai-Ichi accident. Information bulletin no. 6 from June 8, 2011

International Nuclear Information System (INIS)

2011-01-01

This news bulletin has been prepared by the French institute of radiation protection and nuclear safety (IRSN) for the information of French residents in Japan. It presents, first, the situation at the date of the bulletin of the radioactive contamination in the provinces close to the Fukushima Dai-ichi damaged site, the follow-up of the commercialisation restrictions of some food products (vegetables, mushrooms, milk). Then, it gives some general recommendations to residents concerning good food consumption practices and supplies a list of particularly impacted areas where it is to be highly avoided to travel to. (J.S.)

Fukushima-Dai-Ichi accident. Information bulletin no. 8 from December 12, 2011

International Nuclear Information System (INIS)

2011-01-01

This news bulletin has been prepared by the French institute of radiation protection and nuclear safety (IRSN) for the information of French residents in Japan. It presents, first, the situation at the date of the bulletin of the food chain contamination in the provinces close to the Fukushima Dai-ichi damaged site, the particular case of rice contamination monitoring and the controls performed at retailer shops. Then, it gives some general recommendations to residents concerning good food consumption and hygiene practices and recommends to avoid any unnecessary travel to the most impacted areas close to the prohibited access area. (J.S.)

On the fit of models to covariances and methodology to the Bulletin.

Science.gov (United States)

Bentler, P M

1992-11-01

It is noted that 7 of the 10 top-cited articles in the Psychological Bulletin deal with methodological topics. One of these is the Bentler-Bonett (1980) article on the assessment of fit in covariance structure models. Some context is provided on the popularity of this article. In addition, a citation study of methodology articles appearing in the Bulletin since 1978 was carried out. It verified that publications in design, evaluation, measurement, and statistics continue to be important to psychological research. Some thoughts are offered on the role of the journal in making developments in these areas more accessible to psychologists.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 37; Issue 3. Microstructural and optical properties of transparent conductive ZnO : Al : Mo films deposited by template-assisted sol–gel method. H-Y He J-F Huang Z He J Lu Q Shen. Volume 37 Issue 3 May 2014 pp 519-525 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 5. Effect of height to diameter ( h / d ) ratio on the deformation behaviour of Fe–Al 2 O 3 metal matrix nanocomposites. PALLAV GUPTA DEVENDRA KUMAR A K JHA OM PARKASH. Volume 39 Issue 5 September 2016 pp 1245-1258 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 35; Issue 5. Effect of rolling deformation and solution treatment on ... By the solution treatment, the elongated and broken crystalline grains recrystallize which leads to the formation of finer grains (<10 m) of austenite. X-ray diffraction analysis has corroborated well with ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Bulletin of Materials Science; Volume 36; Issue 4. Magnetic resonance in superparamagnetic zinc ferrite. Jitendra Pal Singh Gagan Dixit R C Srivastava Hemant Kumar H M Agrawal Prem Chand. Volume 36 Issue 4 August 2013 pp 751-754 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 36; Issue 5. Thickness effect on properties of titanium film deposited by d.c. magnetron sputtering and electron beam evaporation techniques. Nishat Arshi Junqing Lu Chan Gyu Lee Jae Hong Yoon Bon Heun Koo Faheem Ahmed. Volume 36 Issue 5 October 2013 pp ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 32; Issue 5 ... of CdTe nanoparticles before and after transfer from liquid phase to polystyrene ... Catalytic synthesis of ZnO nanorods on patterned silicon wafer—An optimum material for gas .... Hot-rolled, warm-rolled and heat treated alloys were examined using optical ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 30; Issue 5. Influence of additives on electrodeposition of bright Zn–Ni alloy on mild steel from acid sulphate bath. S Shivakumara U Manohar Y Arthoba Naik T V Venkatesha. Alloys and Steels Volume 30 Issue 5 October 2007 pp 455-462 ...

Bullying in Schools: An Overview. Juvenile Justice Bulletin

Science.gov (United States)

Seeley, Ken; Tombari, Martin L.; Bennett, Laurie J.; Dunkle, Jason B.

2011-01-01

Researchers from the National Center for School Engagement conducted a series of studies to explore the connections between bullying in schools, school attendance and engagement, and academic achievement. This bulletin provides an overview of the studies funded by the Office of Juvenile Justice and Delinquency Prevention (OJJDP), a summary of the…

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 35; Issue 5 .... Influence of different heat treatment programs on properties of sol–gel ... The strong preferred c-axis orientation is lost due to cadmium doping and degree ... Electrical transport and EPR investigations: A comparative study for d.c. conduction mechanism in ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 7. Theoretical study of built-in-polarization effect on relaxation time and mean free path of phonons in Al x Ga 1 − x N alloy. B K SAHOO A PANSARI. Volume 39 Issue 7 December 2016 pp 1835-1841 ...

Protein expression profiling of the drosophila fragile X mutant brain reveals up-regulation of monoamine synthesis.

Science.gov (United States)

Zhang, Yong Q; Friedman, David B; Wang, Zhe; Woodruff, Elvin; Pan, Luyuan; O'donnell, Janis; Broadie, Kendal

2005-03-01

Fragile X syndrome is the most common form of inherited mental retardation, associated with both cognitive and behavioral anomalies. The disease is caused by silencing of the fragile X mental retardation 1 (fmr1) gene, which encodes the mRNA-binding, translational regulator FMRP. Previously we established a disease model through mutation of Drosophila fmr1 (dfmr1) and showed that loss of dFMRP causes defects in neuronal structure, function, and behavioral output similar to the human disease state. To uncover molecular targets of dFMRP in the brain, we use here a proteomic approach involving two-dimensional difference gel electrophoresis analyses followed by mass spectrometry identification of proteins with significantly altered expression in dfmr1 null mutants. We then focus on two misregulated enzymes, phenylalanine hydroxylase (Henna) and GTP cyclohydrolase (Punch), both of which mediate in concert the synthetic pathways of two key monoamine neuromodulators, dopamine and serotonin. Brain enzymatic assays show a nearly 2-fold elevation of Punch activity in dfmr1 null mutants. Consistently brain neurochemical assays show that both dopamine and serotonin are significantly increased in dfmr1 null mutants. At a cellular level, dfmr1 null mutant neurons display a highly significant elevation of the dense core vesicles that package these monoamine neuromodulators for secretion. Taken together, these data indicate that dFMRP normally down-regulates the monoamine pathway, which is consequently up-regulated in the mutant condition. Elevated brain levels of dopamine and serotonin provide a plausible mechanistic explanation for aspects of cognitive and behavioral deficits in human patients.

Rebuild of the Bulletin of the International Seismological Centre (ISC), part 1: 1964-1979

Science.gov (United States)

Storchak, Dmitry A.; Harris, James; Brown, Lonn; Lieser, Kathrin; Shumba, Blessing; Verney, Rebecca; Di Giacomo, Domenico; Korger, Edith I. M.

2017-12-01

The data from the Bulletin of the International Seismological Centre (ISC) have always been and still remain in demand for a wide range of studies in Geosciences. The unique features of the Bulletin include long-term coverage (1904-present), the most comprehensive set of included seismic data from the majority of permanent seismic networks at any given time in the history of instrumental recording (currently 150) and homogeneity of the data and their representation. In order to preserve this homogeneity, the ISC has followed its own standard seismic event processing procedures that have not substantially changed until the early 2000s. Several considerable and necessary advancements in the ISC data collection and seismic event location procedures have created a need to rebuild the data for preceding years in line with the new procedures. Thus was set up a project to rebuild the ISC Bulletin for the period from the beginning of the ISC data till the end of data year 2010. The project is known as the Rebuild of the ISC Bulletin. From data month of January 2011, the ISC data have already been processed with the fully tested and established new procedures and do not require an alteration. It was inconceivable even to think about such a project for many tens of years, but great advances in computer power and increased support by the ISC Member-Institutions and Sponsors have given us a chance to perform this project. Having obtained a lot of experience on the way, we believe that within a few years the entire period of the ISC data will be reprocessed and extended for the entire period of instrumental seismological recordings from 1904 till present. The purpose of this article is to describe the work on reprocessing the ISC Bulletin data under the Rebuild project. We also announce the release of the rebuilt ISC Bulletin for the period 1964-1979 with all seismic events reprocessed and relocated in line with the modern ISC procedures, 68,000 new events, 255 new stations

EINGEERING BULLETINS: AIDS TO THE DEVELOPMENT OF REMEDIAL ALTERNATIVES

Science.gov (United States)

An overview of activities of the Risk Reduction Engineering Laboratory in response to the Environmental Protection Agency`s Treatability Initiative are described and a summary of the information in the first ten Engineering Bulletins, which are a component of the initiative, is p...

Public safety around dams : proposed technical bulletins

Energy Technology Data Exchange (ETDEWEB)

Raska, C [BC Hydro, Burnaby, BC (Canada); Rowat, L [Ontario Power Generation Inc., Niagara Falls, ON (Canada)

2009-07-01

This presentation provided an introduction to the Canadian Dam Association (CDA) public safety guideline and proposed technical bulletins for exterior danger and warning signs; waterway booms and buoys; and audible and visual alerts for water conveyance structures. The presentation outlined the hierarchy of documents for principles, guidelines and technical bulletins. Effective signage includes signs in which the text is sized according to the viewing distance; the message identifies the hazard and the actions to take; and the wording is understood by the public. The criteria for effective booms and buoys were discussed in terms of visibility of booms; types of buoys to use; distance between booms floats; design issues for headpond application versus tailrace application; angling to facilitate self-rescue; and distance from structure. Proposed criteria for audible and visual alerts were also discussed. The audible and visual danger signal should have a designated signal reception area where people can recognize and react to the signal. If a visual signalling device is used, it should be red to indicate danger. Maintenance and inspection tests should be performed regularly on audible and visual signalling devices. 1 ref., 2 figs.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Articles written in Bulletin of Materials Science. Volume 27 Issue 5 October 2004 pp 417-420 Nuclear Related Materials. Irradiation of large area Mylar membrane and characterization of ... Effect of ion beam irradiation on metal particle doped polymer composites · N L Singh Sejal Shah Anjum Qureshi A Tripathi F Singh D K ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 35; Issue 4. CuO/TiO2 nanocrystals grown on graphene as visible-light responsive photocatalytic hybrid materials. Yuan Fang Rijing Wang Guohua Jiang He Jin Yin Wang Xinke Sun Sheng Wang Tao Wang. Volume 35 Issue 4 August 2012 pp 495-499 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 24; Issue 6. Tailoring magnetic and dielectric properties of rubber ferrite composites containing mixed ferrites. M R Anantharaman K A Malini S Sindhu E M Mohammed S K Date S D Kulkarni P A Joy Philip Kurian. Magnetic Materials Volume 24 Issue 6 December 2001 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 5. Structure and magnetic properties of Zr–Mn substituted strontium hexaferrite Sr(Zr,Mn) x Fe 12 − 2 x O 19 nanoparticles synthesized by sol–gel auto-combustion method. S ALAMOLHODA S M MIRKAZEMI Z GHIAMI M NIYAIFAR. Volume 39 Issue 5 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

K Ramachandran. Articles written in Bulletin of Materials Science. Volume 25 Issue 4 August 2002 pp ... Volume 27 Issue 5 October 2004 pp 403-407 Phase Transitions. Phase transition in L-alaninium oxalate by ... Thermal and structural properties of spray pyrolysed CdS thin film · P Raji C Sanjeeviraja K Ramachandran.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 29; Issue 2. Thermoluminescence dosimetry of rare earth doped calcium aluminate phosphors. K Madhukumar K Rajendra Babu K C Ajith Prasad J James T S Elias V Padmanabhan C M K Nair. Ceramics and Glasses Volume 29 Issue 2 April 2006 pp 119-122 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 38; Issue 4 ... of the nanoporous titania films attached with and without photosensitizer TCPP .... The positive values of free energy indicate the non-spontaneity of the sorption of HNTs ..... Effect of RF power and gas flow ratio on the growth and morphology of the PECVD ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 1. Preparation of new thermoluminescent material ( 100 − x )B 2 O 3 –xLi 2 O: Cu 2 + for sensing and detection of radiation. Zeid A Alothman Tansir Ahamad Mu Naushad Saad M Alshehri. Volume 39 Issue 1 February 2016 pp 331-336 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Refresher Courses · Symposia · Live Streaming. Home; Journals; Bulletin of Materials Science; Volume 36; Issue 4. Enhanced high temperature performance of LiMn2O4 coated with Li3BO3 solid electrolyte. Liu Jinlian Wu Xianming Chen Shang Liu Jianben He Zeqiang. Volume 36 Issue 4 August 2013 pp 687-691 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 23; Issue 3. Optimization of growth of InGaAs/InP quantum wells using photoluminescence and secondary ion mass spectrometry. S Bhunia P Banerji T K Chaudhuri A R Haldar D N Bose Y Aparna M B Chettri B R Chakraborty. Semiconducting Materials Volume 23 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 3. Structural investigation of V 2 O 5 –P 2 O 5 –K 2 O glass system with antibacterial potential. N S VEDEANU I B COZAR R STANESCU R STEFAN D VODNAR O COZAR. Volume 39 Issue 3 June 2016 pp 697-702 ...

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 41; Issue 2. Effect of oxygen vacancies on Li-storage of anatase TiO 2 (001) facets: a first principles study. H CHEN Y H DING X Q TANG W ZHANG J R YIN P ZHANG Y JIANG. Volume 41 Issue 2 April 2018 Article ID 51 ...

Monthly bulletin of electric power market - November 1988

International Nuclear Information System (INIS)

1988-01-01

This bulletin deals with the brazilian electric power consumption in November 1988, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Monthly bulletin of electric power market - July 1988

International Nuclear Information System (INIS)

1988-01-01

This bulletin deals with the brazilian electric power consumption in July 1988, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Monthly bulletin of electric power market - September 1988

International Nuclear Information System (INIS)

1988-01-01

This bulletin deals with the brazilian electric power consumption in September 1988, containing data about the total consumption, the growth rates, the special tariffs and monthly evolution in each brazilian region. The economic indexes of industrial production, the market and the prices of electric power and petroleum products are also presented. (C.G.C.)

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Bulletin of Materials Science; Volume 29; Issue 4. Acoustic study of nano-crystal embedded PbO–P2O5 glass. Sudip K Batabyal A Paul P Roychoudhury C Basu. Ceramics and Glasses Volume 29 Issue 4 August 2006 pp 357-363 ...

Are Private Interests Clouding the Peer-Review Process of the WHO Bulletin? A Case Study.

Science.gov (United States)

Homedes, Nuria; Ugalde, Antonio

2016-01-01

Readers' trust on the medical literature has been eroded, and journal editors and some editorial boards are taking measures to ensure that authors fully and accurately report research findings and disclose conflicts of interest. This article describes a case study in which the papers editor of the World Health Organization (WHO) Bulletin influenced the content of an article that had been approved by the external reviewers. The editor objected to the publication of the large price differentials of the new molecular entities (NMEs) across the Latin American countries where they had been tested and the limited added therapeutic value of the NMEs that had been assessed by independent drug bulletins. This article summarizes the exchanges with WHO staff and posits the hypothesis that the WHO Bulletin might be affected by the shifts in WHO financing. Several authors have raised concern about the impact of financial conflicts of interest in WHO activities in the field of nutrition, intellectual property, and in the emergency response to the flu pandemic. Moreover, it has been reported that powerful WHO contributors pressured WHO into revising its publication policy. This is the first time that authors question if these conflicts of interest are also affecting the editorial independence of the WHO Bulletin.

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

Directory of Open Access Journals (Sweden)

Roman Smidak

2017-11-01

Full Text Available Fragile X mental retardation protein (FMRP encoded by Fragile X mental retardation 1 (FMR1 gene is a RNA-binding regulator of mRNA translation, transport and stability with multiple targets responsible for proper synaptic function. Epigenetic silencing of FMR1 gene expression leads to the development of Fragile X syndrome (FXS that is characterized by intellectual disability and other behavioral problems including autism. In the rat FXS model, the lack of FMRP caused a deficit in hippocampal-dependent memory. However, the hippocampal changes of FMRP in aging rats are not fully elucidated. The current study addresses the changes in FMRP levels in dentate gyrus (DG from young (17 weeks and aging (22 months Sprague – Dawley rats. The aging animal group showed significant decline in spatial reference memory. Protein samples from five rats per each group were analyzed by quantitative proteomic analysis resulting in 153 significantly changed proteins. FMRP showed significant reduction in aging animals which was confirmed by immunoblotting and immunofluorescence microscopy. Furthermore, bioinformatic analysis of the differential protein dataset revealed several functionally related protein groups with individual interactions with FMRP. These include high representation of the RNA translation and processing machinery connected to FMRP and other RNA-binding regulators including CAPRIN1, the members of Pumilio (PUM and CUG-BP, Elav-like (CELF family, and YTH N(6-methyladenosine RNA-binding proteins (YTHDF. The results of the current study point to the important role of FMRP and regulation of RNA processing in the rat DG and memory decline during the aging process.

ICFA Instrumentation Bulletin, Volume 22, Spring 2001 Issue (SLAC-J-ICFA-022)

Energy Technology Data Exchange (ETDEWEB)

Va' Vra, J.

2003-10-21

The publication of the ICFA Instrumentation Bulletin is an activity of the Panel on Future Innovation and Development of ICFA (International Committee for Future Accelerators). The Bulletin reports on research and progress in the field of instrumentation with emphasis on application in the field of high-energy physics. It encourages issues of generic instrumentation. This volume contains the following articles: (1) ''Gaseous Micropattern Detectors: High-Energy Physics and Beyond''; (2) ''DIRC Dreams Redux: Research Directions for the Next Generation of Internally Reflected Imaging Counters''; and (3) ''Corrosion of Glass Windows in DIRC PMTs''.

Dependence regulation in newlywed couples: A prospective examination.

Science.gov (United States)

Derrick, Jaye L; Leonard, Kenneth E; Homish, Gregory G

2012-12-01

According to the Risk Regulation Model (Murray, S. L., Holmes, J. G., & Collins, N. L. (2006). Optimizing assurance: The risk regulation system in relationships. Psychological Bulletin, 132 , 641-666), people need to trust in their partner's regard before they risk interdependence. The current study prospectively examines the association between perceived regard and levels of dependence in newlywed couples over nine years of marriage. Analyses demonstrate that changes in perceived regard predict levels of dependence, changes in dependence do not predict perceived regard, and alternative explanations cannot account for these effects. Further, changes in perceived regard prospectively predict divorce, and levels of dependence mediate this association. Results are discussed in terms of the dependence regulation component of the Risk Regulation Model.