Nuclear regulation in transition

International Nuclear Information System (INIS)

Tomain, J.P.

1986-01-01

The current state of nuclear regulations in the USA is examined. Since Three Mile Island the regulation of the nuclear power industry has been undergoing a noticeable transition. It will be argued here that the transition is characterized by two indicia. First, the primary focus of state and federal regulators has been on the financial aspects of the industry: this is best seen in the context of decisions allocating the costs of nuclear plant cancellations. Second, decisionmaking power has been decentralized: although the regulatory history of nuclear power demonstrates the tradition of centralized decisionmaking power (i.e., formerly the primary decisionmaking body was the Atomic Energy Commission), now States share decisionmaking power with the Nuclear Regulatory Commission. In Section 1 a brief legislative history of nuclear regulation is presented to establish the assertion that nuclear regulation, both de jure and de facto, was centralized. Next, Section 2 canvasses recent United States Supreme Court opinions regarding nuclear regulation. The Court frequently acts as policymaker through the consequences of its opinions, if not by its intent. In the area of nuclear policymaking, the Court has paid allegiance recently both to the tradition of centralization and to the movement toward decentralization. This dualism is reflected in other federal court decisions as well which will be briefly mentioned. Continuing the analysis of Federal regulation, Section 3 examines the current reform efforts of the NRC. Section 4 presents an examination of State responses to nuclear plant cancellations. In this section, State administrative agency and court decisions will be examined and recent State legislation will be discussed. (author)

Nuclear regulation in transition

Energy Technology Data Exchange (ETDEWEB)

Tomain, J.P. (Cincinnati Univ., OH, US. Coll. of Law)

1986-01-01

The current state of nuclear regulations in the USA is examined. Since Three Mile Island the regulation of the nuclear power industry has been undergoing a noticeable transition. It will be argued here that the transition is characterized by two indicia. First, the primary focus of state and federal regulators has been on the financial aspects of the industry: this is best seen in the context of decisions allocating the costs of nuclear plant cancellations. Second, decisionmaking power has been decentralized: although the regulatory history of nuclear power demonstrates the tradition of centralized decisionmaking power (i.e., formerly the primary decisionmaking body was the Atomic Energy Commission), now States share decisionmaking power with the Nuclear Regulatory Commission. In Section 1 a brief legislative history of nuclear regulation is presented to establish the assertion that nuclear regulation, both de jure and de facto, was centralized. Next, Section 2 canvasses recent United States Supreme Court opinions regarding nuclear regulation. The Court frequently acts as policymaker through the consequences of its opinions, if not by its intent. In the area of nuclear policymaking, the Court has paid allegiance recently both to the tradition of centralization and to the movement toward decentralization. This dualism is reflected in other federal court decisions as well which will be briefly mentioned. Continuing the analysis of Federal regulation, Section 3 examines the current reform efforts of the NRC. Section 4 presents an examination of State responses to nuclear plant cancellations. In this section, State administrative agency and court decisions will be examined and recent State legislation will be discussed.

The impact of price-cap regulations on market entry by generic pharmaceutical firms.

Science.gov (United States)

Zhang, Wei; Sun, Huiying; Guh, Daphne; Anis, Aslam H

2017-04-01

In 1998, the province of Ontario, Canada implemented price-cap '70/90' regulations: the first generic must be priced at ≤70% of the associated brand-name price and subsequent generics must be priced at ≤90% of the first generics' price. The price-cap was further lowered to 50% in 2006 and 25% in 2010 for all generic drugs regardless of the first or subsequent generic entrants. This study assessed the impact of such price-cap regulations on market entry by generic firms using the formulary database from 9 provinces (January 2004-March 2013). A logistic regression was estimated to compare the probability of entry during the three policy periods in Ontario ('70/90', '25', versus '50'). Since different price-caps were subsequently introduced in other provinces, Alberta, British Columbia, New Brunswick and Saskatchewan, difference-in-differences was used to compare market entry. In Ontario, compared with the period '50', generic firms were 76% and 63% less likely to enter markets in the periods '25' and '70/90', respectively. The difference-in-differences showed that the entry probability decreased the most in Ontario during the '25' period from the '50' period. Lowering the price-cap level to 25% leads to a significantly lower probability of market entry by generic firms.

New Nuclear Safety Regulations

International Nuclear Information System (INIS)

Novosel, N.; Prah, M.; Cizmek, A.

2008-01-01

Beside new Ordinance on the control of nuclear material and special equipment (Official Gazette No. 15/08), from 2006 State Office for Nuclear Safety (SONS) adopted Ordinance on performing nuclear activities (Official Gazette No. 74/06) and Ordinance on special conditions for individual activities to be performed by expert organizations which perform activities in the area of nuclear safety (Official Gazette No. 74/06), based on Nuclear Safety Act (Official Gazette No. 173/03). The Ordinance on performing nuclear activities regulates the procedure of announcing the intention to perform nuclear activity, submitting an application for the issue of a license to perform nuclear activity, and the procedure for adoption a decision on issuing a nuclear activity license. The Ordinance also regulates the contents of the application form for the announcement of the intention to perform nuclear activity, as well as of the application for the issue of a nuclear activity license and the method of keeping a nuclear activity register. The Ordinance on special conditions for individual activities to be performed by expert organizations which perform activities in the area of nuclear safety regulates these mentioned conditions, whereas compliance is established by a decision passed by the SONS. Special conditions for individual activities to be performed by expert organizations which perform activities in the area of nuclear safety are organizational, technical, technological conditions and established system of quality assurance. In 2007, SONS finalized the text of new Ordinance on nuclear safety and protection conditions for location, design, construction, operation and decommissioning of facility in which nuclear activity is performed. This Ordinance regulates nuclear safety and protection conditions for location, design, construction, operation and decommissioning of facility in which nuclear activity is performed. This Ordinance defines facilities in which nuclear activity is

Anti-sense expression of a metallopeptidase gene enhances nuclear entry of HBV-DNA

International Nuclear Information System (INIS)

Yeh, C.-T.; Lai, H.-Y.; Chu, S.-P.; Tseng, I-Chu

2004-01-01

Although several putative hepatitis B virus (HBV) receptors have been identified, none of them is capable of initiating HBV replication in a non-permissive human cell line. Using an Epstein-Barr virus-based extrachromosomal replication system, we have screened through a human liver cDNA library and successfully identified a clone capable of facilitating nuclear transport of HBV-DNA during the early phase of HBV infection. This clone contained a cDNA encoding a metallopeptidase-like protein in anti-sense orientation. Pretreatment of naive HepG2 cells with 1,10-phenanthroline, an inhibitor for liver metallopeptidases, led to nuclear entry of HBV-DNA after HBV infection. However, cccDNA was still undetectable in the nuclei, indicating other cellular factors required to complete the replication cycle were still missing. Our present data suggest that in the initial stage of HBV infection, liver metallopeptidase constitutes a barrier for effective nuclear entry of HBV genomic DNA. Attenuation of metallopeptidase activity may facilitate HBV infection

Up-regulation of Store-operated Ca2+ Entry and Nuclear Factor of Activated T Cells Promote the Acinar Phenotype of the Primary Human Salivary Gland Cells*

Science.gov (United States)

Jang, Shyh-Ing; Ong, Hwei Ling; Liu, Xibao; Alevizos, Ilias; Ambudkar, Indu S.

2016-01-01

The signaling pathways involved in the generation and maintenance of exocrine gland acinar cells have not yet been established. Primary human salivary gland epithelial cells, derived from salivary gland biopsies, acquired an acinar-like phenotype when the [Ca2+] in the serum-free medium (keratinocyte growth medium, KGM) was increased from 0.05 mm (KGM-L) to 1.2 mm (KGM-H). Here we examined the mechanism underlying this Ca2+-dependent generation of the acinar cell phenotype. Compared with cells in KGM-L, those in KGM-H display enhancement of Orai1, STIM1, STIM2, and nuclear factor of activated T cells 1 (NFAT1) expression together with an increase in store-operated Ca2+ entry (SOCE), SOCE-dependent nuclear translocation of pGFP-NFAT1, and NFAT-dependent but not NFκB-dependent gene expression. Importantly, AQP5, an acinar-specific protein critical for function, is up-regulated in KGM-H via SOCE/NFAT-dependent gene expression. We identified critical NFAT binding motifs in the AQP5 promoter that are involved in Ca2+-dependent up-regulation of AQP5. These important findings reveal that the Ca2+-induced switch of salivary epithelial cells to an acinar-like phenotype involves remodeling of SOCE and NFAT signaling, which together control the expression of proteins critically relevant for acinar cell function. Our data provide a novel strategy for generating and maintaining acinar cells in culture. PMID:26903518

Regulating nuclear fuel waste

International Nuclear Information System (INIS)

1995-01-01

When Parliament passed the Atomic Energy Control Act in 1946, it erected the framework for nuclear safety in Canada. Under the Act, the government created the Atomic Energy Control Board and gave it the authority to make and enforce regulations governing every aspect of nuclear power production and use in this country. The Act gives the Control Board the flexibility to amend its regulations to adapt to changes in technology, health and safety standards, co-operative agreements with provincial agencies and policy regarding trade in nuclear materials. This flexibility has allowed the Control Board to successfully regulate the nuclear industry for more than 40 years. Its mission statement 'to ensure that the use of nuclear energy in Canada does not pose undue risk to health, safety, security and the environment' concisely states the Control Board's primary objective. The Atomic Energy Control Board regulates all aspects of nuclear energy in Canada to ensure there is no undue risk to health, safety, security or the environment. It does this through a multi-stage licensing process

Nuclear Protein Sam68 Interacts with the Enterovirus 71 Internal Ribosome Entry Site and Positively Regulates Viral Protein Translation.

Science.gov (United States)

Zhang, Hua; Song, Lei; Cong, Haolong; Tien, Po

2015-10-01

Enterovirus 71 (EV71) recruits various cellular factors to assist in the replication and translation of its genome. Identification of the host factors involved in the EV71 life cycle not only will enable a better understanding of the infection mechanism but also has the potential to be of use in the development of antiviral therapeutics. In this study, we demonstrated that the cellular factor 68-kDa Src-associated protein in mitosis (Sam68) acts as an internal ribosome entry site (IRES) trans-acting factor (ITAF) that binds specifically to the EV71 5' untranslated region (5'UTR). Interaction sites in both the viral IRES (stem-loops IV and V) and the heterogeneous nuclear ribonucleoprotein K homology (KH) domain of Sam68 protein were further mapped using an electrophoretic mobility shift assay (EMSA) and biotin RNA pulldown assay. More importantly, dual-luciferase (firefly) reporter analysis suggested that overexpression of Sam68 positively regulated IRES-dependent translation of virus proteins. In contrast, both IRES activity and viral protein translation significantly decreased in Sam68 knockdown cells compared with the negative-control cells treated with short hairpin RNA (shRNA). However, downregulation of Sam68 did not have a significant inhibitory effect on the accumulation of the EV71 genome. Moreover, Sam68 was redistributed from the nucleus to the cytoplasm and interacts with cellular factors, such as poly(rC)-binding protein 2 (PCBP2) and poly(A)-binding protein (PABP), during EV71 infection. The cytoplasmic relocalization of Sam68 in EV71-infected cells may be involved in the enhancement of EV71 IRES-mediated translation. Since Sam68 is known to be a RNA-binding protein, these results provide direct evidence that Sam68 is a novel ITAF that interacts with EV71 IRES and positively regulates viral protein translation. The nuclear protein Sam68 is found as an additional new host factor that interacts with the EV71 IRES during infection and could potentially

Up-regulation of Store-operated Ca2+ Entry and Nuclear Factor of Activated T Cells Promote the Acinar Phenotype of the Primary Human Salivary Gland Cells.

Science.gov (United States)

Jang, Shyh-Ing; Ong, Hwei Ling; Liu, Xibao; Alevizos, Ilias; Ambudkar, Indu S

2016-04-15

The signaling pathways involved in the generation and maintenance of exocrine gland acinar cells have not yet been established. Primary human salivary gland epithelial cells, derived from salivary gland biopsies, acquired an acinar-like phenotype when the [Ca(2+)] in the serum-free medium (keratinocyte growth medium, KGM) was increased from 0.05 mm (KGM-L) to 1.2 mm (KGM-H). Here we examined the mechanism underlying this Ca(2+)-dependent generation of the acinar cell phenotype. Compared with cells in KGM-L, those in KGM-H display enhancement of Orai1, STIM1, STIM2, and nuclear factor of activated T cells 1 (NFAT1) expression together with an increase in store-operated Ca(2+) entry (SOCE), SOCE-dependent nuclear translocation of pGFP-NFAT1, and NFAT-dependent but not NFκB-dependent gene expression. Importantly, AQP5, an acinar-specific protein critical for function, is up-regulated in KGM-H via SOCE/NFAT-dependent gene expression. We identified critical NFAT binding motifs in the AQP5 promoter that are involved in Ca(2+)-dependent up-regulation of AQP5. These important findings reveal that the Ca(2+)-induced switch of salivary epithelial cells to an acinar-like phenotype involves remodeling of SOCE and NFAT signaling, which together control the expression of proteins critically relevant for acinar cell function. Our data provide a novel strategy for generating and maintaining acinar cells in culture. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Nuclear regulations and environment

International Nuclear Information System (INIS)

Oliveira, Antonio A.

2001-01-01

After an historical overview of the nuclear regulation system in Argentina a description is made of the country's Nuclear Regulatory Authority (ARN) and of its regulation and control functions. Its organic structure is also outlined. A detailed report is given of the environmental monitoring activities in the sites of the operating Argentine nuclear power plants as well as those of the nuclear research centres. A special reference is made of the monitoring of the relevant uranium mining districts in Argentina. The radon determination in houses of several regions of the country is also mentioned

Nuclear fuel cycle and legal regulations

International Nuclear Information System (INIS)

Shimoyama, Shunji; Kaneko, Koji.

1980-01-01

Nuclear fuel cycle is regulated as a whole in Japan by the law concerning regulation of nuclear raw materials, nuclear fuel materials and reactors (hereafter referred to as ''the law concerning regulation of reactors''), which was published in 1957, and has been amended 13 times. The law seeks to limit the use of atomic energy to peaceful objects, and nuclear fuel materials are controlled centering on the regulation of enterprises which employ nuclear fuel materials, namely regulating each enterprise. While the permission and report of uses are necessary for the employment of nuclear materials under Article 52 and 61 of the law concerning regulation of reactors, the permission provisions are not applied to three kinds of enterprises of refining, processing and reprocessing and the persons who install reactors as the exceptions in Article 52, when nuclear materials are used for the objects of the enterprises themselves. The enterprises of refining, processing and reprocessing and the persons who install reactors are stipulated respectively in the law. Accordingly the nuclear material regulations are applied only to the users of small quantity of such materials, namely universities, research institutes and hospitals. The nuclear fuel materials used in Japan which are imported under international contracts including the nuclear energy agreements between two countries are mostly covered by the security measures of IAEA as internationally controlled substances. (Okada, K.)

Harmonization of nuclear and radiation safety regulations for nuclear power plants with reference levels of Western European Nuclear Regulators Association (WENRA)

International Nuclear Information System (INIS)

Bojchuk, V.S.; Mikolajchuk, O.A.; Gromov, G.V.; Dibach, O.M.; Godovanyuk, G.M.; Nosovs'kij, A.V.

2014-01-01

Self-evaluation of the Ukrainian regulations on nuclear and radiation safety that apply to nuclear power plants for compliance with the reference levels of the Western European Nuclear Regulators Association (WENRA) is presented. Proposals on improvement of the regulations upon self-evaluation are provided

KPNB1 mediates PER/CRY nuclear translocation and circadian clock function.

Science.gov (United States)

Lee, Yool; Jang, A Reum; Francey, Lauren J; Sehgal, Amita; Hogenesch, John B

2015-08-29

Regulated nuclear translocation of the PER/CRY repressor complex is critical for negative feedback regulation of the circadian clock of mammals. However, the precise molecular mechanism is not fully understood. Here, we report that KPNB1, an importin β component of the ncRNA repressor of nuclear factor of activated T cells (NRON) ribonucleoprotein complex, mediates nuclear translocation and repressor function of the PER/CRY complex. RNAi depletion of KPNB1 traps the PER/CRY complex in the cytoplasm by blocking nuclear entry of PER proteins in human cells. KPNB1 interacts mainly with PER proteins and directs PER/CRY nuclear transport in a circadian fashion. Interestingly, KPNB1 regulates the PER/CRY nuclear entry and repressor function, independently of importin α, its classical partner. Moreover, inducible inhibition of the conserved Drosophila importin β in lateral neurons abolishes behavioral rhythms in flies. Collectively, these data show that KPNB1 is required for timely nuclear import of PER/CRY in the negative feedback regulation of the circadian clock.

Nuclear regulation - the Canadian approach

International Nuclear Information System (INIS)

Jennekens, J.

1981-09-01

Although the Atomic Energy Control Board was established 35 years ago the basic philosophy of nuclear regulation in Canada and the underlying principles of the regulatory process remain essentially unchanged. This paper outlines the Canadian approach to nuclear regulation and explains in practical terms how the principles of regulation are applied. (author)

Nuclear safety regulations

International Nuclear Information System (INIS)

1998-01-01

The Departmental Rules and The Safety Guides were issued by the NNSA in 1998. The NNSA performed the activities of propagation and implementation of nuclear safety regulations at QTNPP in order to improve the nuclear safety culture of operating organization and construct and contract organizations

Nuclear regulation and safety

International Nuclear Information System (INIS)

Hendrie, J.M.

1982-01-01

Nuclear regulation and safety are discussed from the standpoint of a hypothetical country that is in the process of introducing a nuclear power industry and setting up a regulatory system. The national policy is assumed to be in favor of nuclear power. The regulators will have responsibility for economic, reliable electric production as well as for safety. Reactor safety is divided into three parts: shut it down, keep it covered, take out the afterheat. Emergency plans also have to be provided. Ways of keeping the core covered with water are discussed

NRC - regulator of nuclear safety

International Nuclear Information System (INIS)

1997-01-01

The U.S. Nuclear Regulatory Commission (NRC) was formed in 1975 to regulate the various commercial and institutional uses of nuclear energy, including nuclear power plants. The agency succeeded the Atomic Energy Commission, which previously had responsibility for both developing and regulating nuclear activities. Federal research and development work for all energy sources, as well as nuclear weapons production, is now conducted by the U.S. Department of Energy. Under its responsibility to protect public health and safety, the NRC has three principal regulatory functions: (1) establish standards and regulations, (2) issue licenses for nuclear facilities and users of nuclear materials, and (3) inspect facilities and users of nuclear materials to ensure compliance with the requirements. These regulatory functions relate to both nuclear power plants and to other uses of nuclear materials - like nuclear medicine programs at hospitals, academic activities at educational institutions, research work, and such industrial applications as gauges and testing equipment. The NRC places a high priority on keeping the public informed of its work. The agency recognizes the interest of citizens in what it does through such activities as maintaining public document rooms across the country and holding public hearings, public meetings in local areas, and discussions with individuals and organizations

Introduction of the Comprehensive Nuclear-Test-Ban Treaty (CTBT) and preparatory activities for its entry into force

Energy Technology Data Exchange (ETDEWEB)

Tani, Hiroshi [Japan Atomic Energy Research Inst., Mutsu Establishment, Mutsu, Aomori (Japan)

2001-03-01

The Comprehensive Nuclear-Test-Ban Treaty (CTBT) is a very important treaty, not only for Japan but also for the world, because it prohibits any nuclear weapon test explosion or any other nuclear explosion anywhere in the world. The treaty however will not enter into force until it has been signed and ratified by all the 44 states listed in Annex 2 to the treaty. Many efforts to facilitate the treaty's early entry into force are being done by many countries and many international organizations. As one of result of these efforts, a Preparatory Commission for the Comprehensive Nuclear-Test-Ban Treaty Organization had be established at a meeting of State Signatories on 19 November 1996, and the Commission started activities to establish global verification regime of the treaty and to prepare for its entry into force. Under the CTBT activities, the Japan Atomic Energy Research Institute (JAERI) is expected to play an important role as supporter for the Japanese Government, especially in a field of an International Monitoring System (IMS). However, there is no appropriate guide book on the CTBT for JAERI staff at present. This report provides some introduction of the CTBT regime and preparatory activities for its entry into force. Only open source information is used for making the report. If anyone need more detail information, it should be asked to contact competent authorities. (author)

A nontranscriptional role for Oct4 in the regulation of mitotic entry

Science.gov (United States)

Zhao, Rui; Deibler, Richard W.; Lerou, Paul H.; Ballabeni, Andrea; Heffner, Garrett C.; Cahan, Patrick; Unternaehrer, Juli J.; Kirschner, Marc W.; Daley, George Q.

2014-01-01

Rapid progression through the cell cycle and a very short G1 phase are defining characteristics of embryonic stem cells. This distinct cell cycle is driven by a positive feedback loop involving Rb inactivation and reduced oscillations of cyclins and cyclin-dependent kinase (Cdk) activity. In this setting, we inquired how ES cells avoid the potentially deleterious consequences of premature mitotic entry. We found that the pluripotency transcription factor Oct4 (octamer-binding transcription factor 4) plays an unappreciated role in the ES cell cycle by forming a complex with cyclin–Cdk1 and inhibiting Cdk1 activation. Ectopic expression of Oct4 or a mutant lacking transcriptional activity recapitulated delayed mitotic entry in HeLa cells. Reduction of Oct4 levels in ES cells accelerated G2 progression, which led to increased chromosomal missegregation and apoptosis. Our data demonstrate an unexpected nontranscriptional function of Oct4 in the regulation of mitotic entry. PMID:25324523

Stanniocalcin 2 Regulates Non-capacitative Ca2+ Entry and Aggregation in Mouse Platelets

Directory of Open Access Journals (Sweden)

Esther López

2018-03-01

Full Text Available Stanniocalcin 2 (STC2 is a fish protein that controls body Ca2+ and phosphate metabolism. STC2 has also been described in mammals, and as platelet function highly depends on both extracellular and intracellular Ca2+, we have explored its expression and function in these cells. STC2−/− mice exhibit shorter tail bleeding time than WT mice. Platelets from STC2-deficient mice showed enhanced aggregation, as well as enhanced Ca2+ mobilization in response to the physiological agonist thrombin (Thr and the diacylglycerol analog, OAG, a selective activator of the non-capacitative Ca2+ entry channels. Interestingly, platelets from STC2−/− mice exhibit attenuated interaction between STIM1 and Orai1 in response to Thr, thus suggesting that STC2 is required for Thr-evoked STIM1-Orai1 interaction and the subsequent store-operated Ca2+ entry (SOCE. We have further assessed possible changes in the expression of the most relevant channels involved in non-capacitative Ca2+ entry in platelets. Then, protein expression of Orai3, TRPC3 and TRPC6 were evaluated by Western blotting, and the results revealed that while the expression of Orai3 was enhanced in the STC2-deficient mice, others like TRPC3 and TRPC6 remains almost unaltered. Summarizing, our results provide for the first time evidence for a role of STC2 in platelet physiology through the regulation of agonist-induced Ca2+ entry, which might be mediated by the regulation of Orai3 channel expression.

Two essays on electricity markets: Entry into hydroelectric generation industry and the political cycle of regulated prices

Science.gov (United States)

Moita, Rodrigo Menon Simoes

This dissertation is about the electricity industry and the problems that arise with the liberalization and de-regulation of the industry. Characteristics intrinsic to the electricity market create problems that can compromise an efficient functioning of this market. Each of the two chapters of this dissertation focus on a specific aspect of this industry. The first chapter analyzes entry in the hydroelectric generation industry. The operation of a generator upstream regularizes the river flow for generators located downstream on the same river, increasing the production capacity of the latter. This positive externality increases the attractiveness of the locations downstream whenever a generator decides to enter upstream. Therefore, the entry decision of a generator in a given location may affect all entry decisions in potential locations for plants located downstream. I first model the problem of generators located in cascade on the same river and show the positive effect of the externality. Second, I use a panel of data on investment decisions of hydro-generation firms to estimate an entry model that takes into account the effect of the externality generated by entry upriver. The results show a positive incentive to locate downstream from existing plants and from locations where entry is likely to occur. Location characteristics also play an important role on the entrants' decisions. The model provides estimates of the average expected market price across the different years covered by the sample and shows that it rose one year before the energy crisis of 2001, evidencing that the market anticipated the crisis. This result has important implications on the evaluation of the Brazilian market design. It shows that entry responded to a rise in expectations about excess demand in the future, contradicting the argument that the crisis was a consequence of mis-designed market institutions. The second chapter deals with the problem of the political cycle in regulated

Mediator can regulate mitotic entry and direct periodic transcription in fission yeast.

Science.gov (United States)

Banyai, Gabor; Lopez, Marcela Davila; Szilagyi, Zsolt; Gustafsson, Claes M

2014-11-01

Cdk8 is required for correct timing of mitotic progression in fission yeast. How the activity of Cdk8 is regulated is unclear, since the kinase is not activated by T-loop phosphorylation and its partner, CycC, does not oscillate. Cdk8 is, however, a component of the multiprotein Mediator complex, a conserved coregulator of eukaryotic transcription that is connected to a number of intracellular signaling pathways. We demonstrate here that other Mediator components regulate the activity of Cdk8 in vivo and thereby direct the timing of mitotic entry. Deletion of Mediator components Med12 and Med13 leads to higher cellular Cdk8 protein levels, premature phosphorylation of the Cdk8 target Fkh2, and earlier entry into mitosis. We also demonstrate that Mediator is recruited to clusters of mitotic genes in a periodic fashion and that the complex is required for the transcription of these genes. We suggest that Mediator functions as a hub for coordinated regulation of mitotic progression and cell cycle-dependent transcription. The many signaling pathways and activator proteins shown to function via Mediator may influence the timing of these cell cycle events. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Entry-Control Systems Handbook

International Nuclear Information System (INIS)

1978-09-01

The function of an entry-control system in a total Physical Protection System is to allow the movement of authorized personnel and material through normal access routes, yet detect and delay unauthorized movement of personnel and material from uncontrolled areas. The ten chapters of this handbook cover: introduction, credentials, personnel identity verification systems, special nuclear materials monitors, metal detectors, explosives sensors, package search systems, criteria for selection of entry-control equipment, machine-aided manual entry-control systems, and automated entry-control systems. A system example and its cost are included as an appendix

Flexible robotic entry device for a nuclear materials production reactor

International Nuclear Information System (INIS)

Heckendorn, F.M. II.

1988-01-01

The Savannah River Laboratory has developed and is implementing a flexible robotic entry device (FRED) for the nuclear materials production reactors now operating at the Savannah River Plant (SRP). FRED is designed for rapid deployment into confinement areas of operating reactors to assess unknown conditions. A unique smart tether method has been incorporated into FRED for simultaneous bidirectional transmission of multiple video/audio/control/power signals over a single coaxial cable. This system makes it possible to use FRED under all operating and standby conditions, including those where radio/microwave transmissions are not possible or permitted, and increases the quantity of data available

Application of Entry-Time Processes to Asset Management in Nuclear Power Plants

International Nuclear Information System (INIS)

Nelson, Paul; Wang, Shuwen; Kee, Ernie J.

2006-01-01

The entry-time approach to dynamic reliability is based upon computational solution of the Chapman-Kolmogorov (generalized state-transition) equations underlying a certain class of marked point processes. Previous work has verified a particular finite-difference approach to computational solution of these equations. The objective of this work is to illustrate the potential application of the entry-time approach to risk-informed asset management (RIAM) decisions regarding maintenance or replacement of major systems within a plant. Results are presented in the form of plots, with replacement/maintenance period as a parameter, of expected annual revenue, along with annual variance and annual skewness as indicators of associated risks. Present results are for a hypothetical system, to illustrate the capability of the approach, but some considerations related to potential application of this approach to nuclear power plants are discussed. (authors)

The Characteristics of an Effective Nuclear Regulator

International Nuclear Information System (INIS)

Cheok, Michael; Wertelaers, An; Lojk, Robert; Santini, Miguel; Alm-Lytz, Kirsi; Rigail, Anne-Cecile; Weidenbruck, Kai-Jochen; Stoppa, Gisela; Rainieri, Roberto; Aoki, Masahiro; Gonzalez-Mercado; Miroshnichenko, Mikhail; Kuznetsov, Nikolay; Kudryavtsev, Evgeny; Cid, Rafael; Franzen, Anna; Skanberg, Lars; Gibson, Steve; Golshan, Mina; Cheok, Michael; Nicic, Adriana; Salgado, Nancy; Creswell, Len

2014-01-01

Both national and international organisations agree that the fundamental objective of all nuclear safety regulatory bodies - the regulator's prime purpose - is to ensure that nuclear licensees operate their facilities at all times in a safe manner. Much has been written about ways to improve regulatory processes or to improve the effectiveness of a regulatory body, including in previous OECD/NEA regulatory guidance booklets. But until now, none have focused on the characteristics of an effective nuclear safety regulator. Effective organisations are those that have good leadership and are able to transform strategic direction into operational programmes. Effectiveness is about how well the organisation is achieving its fundamental purpose - in the case of a nuclear safety regulator, ensuring that licensees operate their facilities and discharge their obligations in a safe manner. This regulatory guidance booklet describes the characteristics of an effective nuclear safety regulator in terms of roles and responsibilities, principles and attributes. Each of the characteristics discussed in this report is a necessary feature of an effective nuclear safety regulator but no one characteristic is sufficient on its own. It is the combination of these characteristics that leads to the effectiveness of a nuclear regulatory body. The report provides a unique resource to countries with existing, mature regulators and can be used for benchmarking as well as training and developing staff. It will also be useful for new entrant countries in the process of developing and maintaining an effective nuclear safety regulator. (authors)

The regulations of the Nuclear Technology Committee

International Nuclear Information System (INIS)

Schwarzer, W.

1984-01-01

The work of the Nuclear Technology Committee (NTC) is characterised by the key words 'safety related regulations' and 'nuclear technology'. The rationalisation effect desired from regulations and the not unlimited number of experts qualified for working out regulations, make it necessary to establish priorities. The NTC has almost exclusively worked out regulations for nuclear powerstations and mainly for light water reactors. The program defined at present seems to cover the most important areas. Future developments can be foreseen in the execution of the part of the program not yet concluded, the maintenance of the regulations and, depending on the development of nuclear technology, the greater inclusion of the HTR and possibly the expansion of the regulations to fast breeder reactors and plant of the fuel circuit. (orig./HSCH) [de

Incentive regulation of nuclear power plants by state regulators

International Nuclear Information System (INIS)

Martin, R.L.; Baker, K.; Olson, J.

1991-02-01

The Nuclear Regulatory Commission (NRC) monitors incentive programs established by state regulators in order to obtain current information and to consider the potential safety effects of the incentive programs as applied to nuclear units. The current report is an update of NUREG/CR-5509, Incentive Regulation of Nuclear Power Plants by State Public Utility Commissions, published in December 1989. The information in this report was obtained from interviews conducted with each state regulator and each utility with a minimum entitlement of 10%. The agreements, orders, and settlements from which each incentive program was implemented were reviewed as required. The interviews and supporting documentation form the basis for the individual state reports describing the structure and financial impact of each incentive program. The programs currently in effect represent the adoption of an existing nuclear performance incentive program proposal and one new program. In addition, since 1989 a number of nuclear units have been included in one existing program; while one program was discontinued and another one concluded. 6 refs., 27 tabs

Sun-mediated mechanical LINC between nucleus and cytoskeleton regulates βcatenin nuclear access.

Science.gov (United States)

Uzer, Gunes; Bas, Guniz; Sen, Buer; Xie, Zhihui; Birks, Scott; Olcum, Melis; McGrath, Cody; Styner, Maya; Rubin, Janet

2018-06-06

βcatenin acts as a primary intracellular signal transducer for mechanical and Wnt signaling pathways to control cell function and fate. Regulation of βcatenin in the cytoplasm has been well studied but βcatenin nuclear trafficking and function remains unclear. In a previous study we showed that, in mesenchymal stem cells (MSC), mechanical blockade of adipogenesis relied on inhibition of βcatenin destruction complex element GSK3β (glycogen synthase kinase 3β) to increase nuclear βcatenin as well as the function of Linker of Cytoskeleton and Nucleoskeleton (LINC) complexes, suggesting that these two mechanisms may be linked. Here we show that shortly after inactivation of GSK3β due to either low intensity vibration (LIV), substrate strain or pharmacologic inhibition, βcatenin associates with the nucleoskeleton, defined as the insoluble nuclear fraction that provides structure to the integrated nuclear envelope, nuclear lamina and chromatin. Co-depleting LINC elements Sun-1 and Sun-2 interfered with both nucleoskeletal association and nuclear entry of βcatenin, resulting in decreased nuclear βcatenin levels. Our findings reveal that the insoluble structural nucleoskeleton actively participates in βcatenin dynamics. As the cytoskeleton transmits applied mechanical force to the nuclear surface to influence the nucleoskeleton and its LINC mediated interaction, our results suggest a pathway by which LINC mediated connectivity may play a role in signaling pathways that depend on nuclear access of βcatenin. Copyright © 2018 Elsevier Ltd. All rights reserved.

Phosphoinositide-3-kinases p110alpha and p110beta mediate S phase entry in astroglial cells in the marginal zone of rat neocortex

Directory of Open Access Journals (Sweden)

Rabea eMüller

2013-03-01

Full Text Available In cells cultured from neocortex of newborn rats, phosphoinositide-3-kinases of class I regulate the DNA synthesis in a subgroup of astroglial cells. We have studied the location of these cells as well as the kinase isoforms which facilitate the S phase entry. Using dominant negative isoforms as well as selective pharmacological inhibitors we quantified S phase entry by nuclear labeling with bromodeoxyuridine. Only in astroglial cells harvested from the marginal zone of the neocortex inhibition of phosphoinositide-3-kinases reduced the nuclear labeling with bromodeoxyuridine, indicating that neocortical astroglial cells differ in the regulation of proliferation. The two kinase isoforms p110 and p110were essential for S phase entry. p110 diminished the level of the p27Kip1 which inactivates the complex of cyclin E and CDK2 necessary for entry into the S phase. p110phosphorylated and inhibited glycogen synthase kinase-3which can prevent S-phase entry. Taken together, both isoforms mediated S phase in a subgroup of neocortical astroglial cells and acted via distinct pathways.

Public regulation of nuclear plants

International Nuclear Information System (INIS)

Burtheret, M.; Cormis, de

1980-01-01

The construction and operation of nuclear plants are subject to a complex system of governmental administration. The authors list the various governmental authorisations and rules applicable to these plants. In the first part, they describe the national regulations which relate specifically to nuclear plants, and emphasize the provisions which are intended to ensure the safety of the installations and the protection of the public against ionizing radiation. However, while the safety of nuclear plants is a major concern of the authorities, other interests are also protected. This is accomplished by various laws or regulations which apply to nuclear plants as well as other industrial installations. The duties which these texts, and the administrative practice based thereon, impose on Electricite de France are covered in the second part [fr

Discussion about risk-informed regulations on the nuclear safety

International Nuclear Information System (INIS)

Gu Yeyi

2008-01-01

The article introduces the background and status quo of regulations on the nuclear safety in China, and points out the inadequacies existing with the current regulations. The author explains the risk-informed safety management concerning its development, status quo, and achievements made, in an attempt to make out the trend of improving regulations on the nuclear safety through risk-informed methods. Combining the U.S. development program of establishing risk-informed regulations on the nuclear safety, the author narrates principles and features of the new regulations system, and provides suggestions for the promotion of risk-informed safety management and establishment of risk-informed regulations on the nuclear safety. (author)

Self trust, a major challenge for nuclear regulators

Energy Technology Data Exchange (ETDEWEB)

Eibenschutz, J. [National Nuclear Safety and Safeguards Commission (CNSN), Mexico City (Mexico)

2014-07-01

Self trust. The nuclear community and particularly nuclear regulators overreact to accidents, this has been the case with the three NPP major accidents. Lowering admissible radiation levels, for example, conveys the wrong message to politicians and the general public, and contributes to enhance mistrust towards nuclear. Industry as well as regulators should mature and act with self respect, since the scientific bases of regulation are very solid and should be trusted. Lessons learned should be seriously pursued in spite of the 'uneven playing field'. Obviously safety continues as the main priority, but paranoid reactions from the nuclear professionals could destroy the future of nuclear power. (author)

Self trust, a major challenge for nuclear regulators

International Nuclear Information System (INIS)

Eibenschutz, J.

2014-01-01

Self trust. The nuclear community and particularly nuclear regulators overreact to accidents, this has been the case with the three NPP major accidents. Lowering admissible radiation levels, for example, conveys the wrong message to politicians and the general public, and contributes to enhance mistrust towards nuclear. Industry as well as regulators should mature and act with self respect, since the scientific bases of regulation are very solid and should be trusted. Lessons learned should be seriously pursued in spite of the 'uneven playing field'. Obviously safety continues as the main priority, but paranoid reactions from the nuclear professionals could destroy the future of nuclear power. (author)

Improving the rationality of nuclear safety regulations

International Nuclear Information System (INIS)

Choi, Byung Sun; Choi, Y. G.; Mun, G. H.

2005-03-01

This study focuses on human nature and institutions around the risk management in Korean Nuclear Installations. Nuclear safety regulatory system in Korea has had a tendency to overvalue the technical or engineering areas. But just like other risk management system, the knowledge of social science is also required to design more valid safety regulatory system. As a result of analysis, this study suggest that performance regulation need to be introduced to current nuclear safety regulation system. In this advanced regulatory system, each nuclear generation unit have to be evaluated by performance of its own regulatory implementation and would be treated differently by the performance. Additionally, self-regulation could be very effective was to guarantee nuclear safety. Because KHNP could be judged to have an considerable capabilities to manage its own regulatory procedures. To make self-regulatory system established successfully, it is also important to arrange the appropriate incentive and compensate structures

Regulating Market Entry of Low-Cost Private Schools in Sub-Saharan Africa : Towards a Theory of Private Education Regulation

OpenAIRE

Baum, Donald R.; Cooper, Rachel; Lusk-Stover, Oni

2018-01-01

This study provides a comparative assessment of policies governing private schools in twenty countries in Sub-Saharan Africa. Findings suggest that current regulatory systems are failing to adequately address the negative externalities and failures of private schooling markets. Insufficient capacity on the part of governments is a contributor to uneven policy implementation and creates opportunities for rent-seeking and corruption. Onerous market entry regulations offer constraints on the gro...

Improvement and rationalization of nuclear energy laws and regulations

International Nuclear Information System (INIS)

Cho, Byung Sun; Lee, Mo Sung; Chung, Gum Chum; Kim, Hak Man; Oh, Ho Chul

2002-03-01

Since the present legal system on nuclear safety regulation has some problems that refer to contents of regulatory provisions, this mid-report has preformed research on the legal basic theory of nuclear safety regulation. And then secondly this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation. In order to interpret easily this report finally took the cases of judicial precedents on nuclear safety regulation in USA, Germany, Japan and Korea

Improvement and rationalization of nuclear energy laws and regulations

Energy Technology Data Exchange (ETDEWEB)

Lee, Mo Sung; Chung, Gum Chun; Kim, Hak Man; Oh, Ho Chul [Cheongju Univ., Cheongju (Korea, Republic of)

2001-03-15

Since the present legal system on nuclear safety regulation has some problems that refer to contents of regulatory provisions, this mid-report has preformed research on the legal basic theory of nuclear safety regulation. And then secondly this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation. In order to interpret easily this report finally took the cases of judicial precedents on nuclear safety regulation in USA, Germany, Japan and Korea.

Improvement and rationalization of nuclear energy laws and regulations

Energy Technology Data Exchange (ETDEWEB)

Cho, Byung Sun; Lee, Mo Sung; Chung, Gum Chum; Kim, Hak Man; Oh, Ho Chul [Chongju Univ., Cheongju (Korea, Republic of)

2002-03-15

Since the present legal system on nuclear safety regulation has some problems that refer to contents of regulatory provisions, this mid-report has preformed research on the legal basic theory of nuclear safety regulation. And then secondly this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation. In order to interpret easily this report finally took the cases of judicial precedents on nuclear safety regulation in USA, Germany, Japan and Korea.

Development regulation regarding with licensing of nuclear installation

International Nuclear Information System (INIS)

Bambang Riyono; Yudi Pramono; Dahlia Cakrawati Sinaga

2011-01-01

Provisions of Article 17 paragraph (3) of Law Number 10 Year 1997 on Nuclear cleary mandates for the establishment of government regulations (GR) on Nuclear licensing containing the requirements and procedure, both from the standpoint of their utilization and installation. To use has been rising GR No.29 Year 2008 on the Use of Ionizing Radiation Sources and Nuclear Materials, while for the installation has been published PP No.43 Year 2006 on Nuclear Reactor Licensing, and BAPETEN Chairman Decree No.3 Year 2006 on Non-reactor Nuclear Installation Licensing. Based on the background of the preparation of both the aforementioned are just regulate the reactor and utilization, not yet fully meet the mandate of Article 17 paragraph (3) of Law No.10 of 1997 on Nuclear, including other nuclear installations. For these reasons, it initiated the need for a separate regulation containing provisions concerning licensing of non-reactor nuclear installations. On the other side from the understanding the legal aspects and interpretations of the Law No.10 of 2004 on the Establishment Regulation Legislation, should be in single mandate of Article 17 paragraph (3) of Law No.10 of 1997 on Nuclear would only produce one of the requirements and procedure for the use or installation, or a maximum of two (2) GR related licensing the use and installation. This is encourages conducted the assessing or studies related to how possible it is according to the legal aspect is justified to combine in one Nuclear licensing regulations regarding both the use and installation, by looking at the complexity of installation and wide scope of utilization of nuclear energy in Indonesia. The results of this paper is expected to provide input in the preparation of GR on licensing of nuclear installations. (author)

Regulation of capacitative and non-capacitative Ca2+ entry in A7r5 vascular smooth muscle cells

Directory of Open Access Journals (Sweden)

COLIN W TAYLOR

2004-01-01

Full Text Available A capacitative Ca2+ entry (CCE pathway, activated by depletion of intracellular Ca2+ stores, is thought to mediate much of the Ca2+ entry evoked by receptors that stimulate phospholipase C (PLC. However, in A7r5 vascular smooth muscle cells, vasopressin, which stimulates PLC, empties intracellular Ca2+ stores but simultaneously inhibits their ability to activate CCE. The diacylglycerol produced with the IP3 that empties the stores is metabolized to arachidonic and this leads to activation of nitric oxide (NO synthase, production of NO and cyclic GMP, and consequent activation of protein kinase G. The latter inhibits CCE. In parallel, NO directly activates a non-capacitative Ca2+ entry (NCCE pathway, which is entirely responsible for the Ca2+ entry that occurs in the presence of vasopressin. This reciprocal regulation of two Ca2+ entry pathways ensures that there is sequential activation of first NCCE in the presence of vasopressin, and then a transient activation of CCE when vasopressin is removed. We suggest that the two routes for Ca2+ entry may selectively direct Ca2+ to processes that mediate activation and then recovery of the cell.

Regulation at nuclear fuel cycle

International Nuclear Information System (INIS)

2002-01-01

This bulletin contains information about activities of the Nuclear Regulatory Authority of the Slovak Republic (UJD). In this leaflet the role of the UJD in regulation at nuclear fuel cycle is presented. The Nuclear Fuel Cycle (NFC) is a complex of activities linked with production of nuclear fuel for nuclear reactors as a source of energy used for production of electricity and heat, and of activities linked with spent nuclear fuel handling. Activities linked with nuclear fuel (NF) production, known as the Front-End of Nuclear Fuel Cycle, include (production of nuclear fuel from uranium as the most frequently used element). After discharging spent nuclear fuel (SNF) from nuclear reactor the activities follow linked with its storage, reprocessing and disposal known as the Back-End of Nuclear Fuel Cycle. Individual activity, which penetrates throughout the NFC, is transport of nuclear materials various forms during NF production and transport of NF and SNF. Nuclear reactors are installed in the Slovak Republic only in commercial nuclear power plants and the NFC is of the open type is imported from abroad and SNF is long-term supposed without reprocessing. The main mission of the area of NFC is supervision over: - assurance of nuclear safety throughout all NFC activities; - observance of provisions of the Treaty on Non-Proliferation of Nuclear Weapons during nuclear material handling; with an aim to prevent leakage of radioactive substances into environment (including deliberated danage of NFC sensitive facilities and misuse of nuclear materials to production of nuclear weapons. The UJD carries out this mission through: - assessment of safety documentation submitted by operators of nuclear installations at which nuclear material, NF and SNF is handled; - inspections concentrated on assurance of compliance of real conditions in NFC, i.e. storage and transport of NF and SNF; storage, transport and disposal of wastes from processing of SNF; with assumptions of the safety

Energy policy study. Volume 10. Nuclear power regulation

International Nuclear Information System (INIS)

Nikodem, Z.D.; Reynolds, A.W.; Clark, R.G.

1980-05-01

This report examines the programs for regulating the safety, design, and operation of domestic nuclear power plants. The first part of the study describes the Federal and State regulatory procedures. It describes the legal foundations for the Federal licensing process and the associated State regulatory activities. It then analyzes the aspects of these procedures that affect the cost and supply of nuclear-generated electricity. The second part of this study examines the effects of nuclear safety regulations on the planning and construction lead time for nuclear power stations, the cost of nuclear power, and, ultimately, the decision to invest in nuclear power

Synergism in regulation of nuclear and radiological activities

International Nuclear Information System (INIS)

Buzdugan, A.

2009-01-01

In 2006 the reform of nuclear activity regulation in Moldova was initiated. On May 11, 2006, the Parliament of the Republic of Moldova passed the law Nr 111-XVI 'About Safe Accomplishment of Nuclear and Radiological Activity'. On the 23rd of March, 2007 the National Agency for Regulation of Nuclear and Radiological Activities (NARNRA) was founded due to the decree of the Government under the Ministry of Ecology and Natural Resources. Its first objective was elaboration of necessary regulation documents in this field

Improving nuclear regulation. Compilation of Nea regulatory guidance booklets

International Nuclear Information System (INIS)

2009-01-01

A common theme throughout the series of NEA regulatory guidance reports, or 'green booklets', is the premise that the fundamental objective of all nuclear safety regulatory bodies is to ensure that nuclear facilities are operated at all times and later decommissioned in an acceptably safe manner. In meeting this objective the regulator must keep in mind that it is the operator that has responsibility for safely operating a nuclear facility; the role of the regulator is to oversee the operator's activities as related to assuming that responsibility. For the first time, the full series of these reports have been brought together in one edition. As such, it is intended to serve as a knowledge management tool both for current regulators and the younger generation of nuclear experts entering the regulatory field. While the audience for this publication is primarily nuclear regulators, the information and ideas may also be of interest to nuclear operators, other nuclear industry organisations and the general public. (author)

Present state of nuclear regulation organizations of main countries in the world. Importance of regulation staffs and requirements

International Nuclear Information System (INIS)

Nishida, Naoki

2013-01-01

After Fukushima accident, NRA (Nuclear Regulation Authority) was established in Japan as an independent organization from promotion. In order to perform effective and reliable nuclear regulation, it was important management organization such as nuclear regulation commission worked efficiently, and also requirements for nuclear regulation staffs engaged in actual regulatory works were of importance so as for appropriate decision making or judgments of management organization. Since regulation staffs needed professional expertise and technical judgment capabilities in wide areas including other than nuclear energy, various efforts had been done to get able regulation staffs in US, France and UK nuclear regulation organizations concerned, which became clarified after overseas investigation for this article. Since knowledge in nuclear industry could be used for effective regulation, mid-career recruitment had been employed in regulation organization of each country so as to take such knowledge and so it was important how to utilize industrial knowledge under appropriate conditions compatible with independence of regulation organization. (T. Tanaka)

Order for execution of the law concerning regulations of nuclear source materials, nuclear fuel materials and reactors

International Nuclear Information System (INIS)

1987-01-01

Chapeter 1 specifies regulations concerning business management for refining and processing, which cover application for designation of refining operation, application for permission for processing operation, and approval of personnel responsible for handling nuclear fuel. Chapter 2 specifies regulations concerning construction and operation of nuclear reactors, which cover application for construction of nuclear reactors, reactors in a research and development stage, application for permission concerning nuclear reactors mounted on foreign nuclear powered ships, application for permission for alteration concerning construction of nuclear reactors, application for permission for alteration concerning nuclear reactors mounted on foreign nuclear powered ships, nuclear reactor facilities to be subjected to regular inspection, nuclear reactor for which submission of operation plan is not required, and application for permission for transfer of nuclear reactor. Chapter 2 also specifies regulations concerning business management for reprocessing and waste disposal. Chapter 3 stipulates regulations concerning use of nuclear fuel substances, nuclear material substances and other substances covered by international regulations, which include rules for application for permission for use of nuclear fuel substances, etc. Supplementary provisions are provided in Chapter 4. (Nogami, K.)

Regulatory risks associated with nuclear safety legislation after Fukushima Daiichi Nuclear Accident in Japan. Focus on legal structure of the nuclear reactor regulation act

International Nuclear Information System (INIS)

Tanabe, Tomoyuki; Maruyama, Masahiro

2016-01-01

Nuclear safety regulations enforced after Fukushima Daiichi Nuclear Accident under the Nuclear Reactor Regulation Act face the following regulatory problems that involve potential risk factors for nuclear businesses; 1) 'entity based regulation' unable to cope with business cessation or bankruptcy of the entity subject of regulation, 2) potential risk of the Nuclear Regulation Authority's inappropriate involvement in nuclear industry policy beyond their duty, and 3) compliance of backfits under vague regulations. In order to alleviate them, this report, through analyzing these regulatory problems from the view point of sound development of the nuclear industry, proposes the following regulatory reforms; (1) To clarify the rule for industry policy in nuclear regulations and enable the authority, Ministry of Economy, Trade and Industry, to choose most appropriate industrial policy measure. (2) Through establishing safety goals as measures to promote continuous improvement of nuclear safety regulations, to stimulate timely adjustments of the regulations, and to introduce a legal mechanism into the nuclear regulation systems under which validity of administrative law and its application can be checked. (author)

Pakistan nuclear safety and radiation protection regulation 1990

International Nuclear Information System (INIS)

1990-01-01

In this act regulations of nuclear safety and radiation protection in Pakistan has been explained. A legal and licensing procedure to handle protection of nuclear materials, processing storage of radioactive products has been described under this regulation. In these regulations full explanation of accidental exposure, delegation of powers and record keeping/waste disposal of radioactive has been given. (A.B.)

Robust optimal self tuning regulator of nuclear reactors

International Nuclear Information System (INIS)

Nouri Khajavi, M.; Menhaj, M.B.; Ghofrani, M.B.

2000-01-01

Nuclear power reactors are, in nature nonlinear and time varying. These characteristics must be considered, if large power variations occur in their working regime. In this paper a robust optimal self-tuning regulator for regulating the power of a nuclear reactor has been designed and simulated. The proposed controller is capable of regulating power levels in a wide power range (10% to 100% power levels). The controller achieves a fast and good transient response. The simulation results show that the proposed controller outperforms the fixed optimal control recently cited in the literature for nuclear power plants

Design features of an automated entry control system

International Nuclear Information System (INIS)

Reynolds, D.A.

1978-01-01

Features of an entry control system designed to automatically control access to nuclear facilities is described. Control independent of variable human factors is stressed, but security force action is required for assessment and response as a result of an alarm. A design based on a distributed processing capability is utilized. Flexibility and generality are emphasized in an effort to maximize applicability to the entry-control problem faced by nuclear facilities upgrading security as a result of the Safeguards Program

Nuclear and radiological regulation in Moldova

International Nuclear Information System (INIS)

Buzdugan, Artur

2013-01-01

The nuclear security and safety legal framework in Moldova has changed significantly over the last 6 years. This has mainly been the result of implementation of IAEA nuclear safety and nuclear security standards, European directives, which are based on new data and evolving concepts at the international level, on adopted in May 2006 of the Law no. 111 On safe deployment of nuclear and radiological activities and establishing on established on March 2007 of a sole regulatory authority - the National Agency for the Regulation of Nuclear and Radiological Activities. (author)

Regulation on control of nuclear fuel materials

International Nuclear Information System (INIS)

Ikeda, Kaname

1976-01-01

Some comment is made on the present laws and the future course of consolidating the regulation of nuclear fuel materials. The first part gives the definitions of the nuclear fuel materials in the laws. The second part deals with the classification and regulation in material handling. Refinement undertaking, fabrication undertaking, reprocessing undertaking, the permission of the government to use the materials, the permission of the government to use the materials under international control, the restriction of transfer and receipt, the reporting, and the safeguard measures are commented. The third part deals with the strengthening of regulation. The nuclear fuel safety deliberation special committee will be established at some opportunity of revising the ordinance. The nuclear material safeguard special committee has been established in the Atomic Energy Commission. The last part deals with the future course of legal consolidation. The safety control will be strengthened. The early investigation of waste handling is necessary, because low level solid wastes are accumulating at each establishment. The law for transporting nuclear materials must be consolidated as early as possible to correspond to foreign transportation laws. Physical protection is awaiting the conclusions of the nuclear fuel safeguard special committee. The control and information systems for the safeguard measures must be consolidated in the laws. (Iwakiri, K.)

Regulation of nuclear and radiological activities; Reglementarea activitatilor nucleare si radiologice

Energy Technology Data Exchange (ETDEWEB)

Sidorencu, Angela; Vasilieva, Natalia; Buzdugan, Artur; Balan, Ionel [Agentia Nationala de Reglementare a Activitatilor Nucleare si Radiologice, Alecu Russo, 1, MD 2068, Chisinau (Moldova, Republic of)

2012-08-15

The paper presents a review of the Moldovan regulatory framework regarding nuclear and radiological activities and of the competence of state regulatory authority - the National Agency for the Regulation of Nuclear and Radiological Activities.

Improving nuclear regulation. NEA regulatory guidance booklets volumes 1-14

International Nuclear Information System (INIS)

2011-01-01

A common theme throughout the series of NEA regulatory guidance reports, or 'green booklets', is the premise that the fundamental objective of all nuclear safety regulatory bodies is to ensure that nuclear facilities are continuously maintained and operated in an acceptably safe manner. In meeting this objective the regulator must bear in mind that it is the operator that has responsibility for safely operating the nuclear facility; the role of the regulator is to assess and to provide assurance regarding the operator's activities in terms of assuming that responsibility. The full series of these reports was brought together in one edition for the first time in 2009 and was widely found to be a useful resource. This second edition comprises 14 volumes, including the latest on The Nuclear Regulator's Role in Assessing Licensee Oversight of Vendor and Other Contracted Services. The reports address various challenges that could apply throughout the lifetime of a nuclear facility, including design, siting, manufacturing, construction, commissioning, operation, maintenance and decommissioning. The compilation is intended to serve as a knowledge management tool both for current regulators and the new nuclear professionals and organisations entering the regulatory field. Contents: Executive Summary; Regulatory Challenges: 1. The Role of the Nuclear Regulator in Promoting and Evaluating Safety Culture; 2. Regulatory Response Strategies for Safety Culture Problems; 3. Nuclear Regulatory Challenges Related to Human Performance; 4. Regulatory Challenges in Using Nuclear Operating Experience; 5. Nuclear Regulatory Review of Licensee Self-assessment (LSA); 6. Nuclear Regulatory Challenges Arising from Competition in Electricity Markets; 7. The Nuclear Regulatory Challenge of Judging Safety Back-fits; 8. The Regulatory Challenges of Decommissioning Nuclear Reactors; 9. The Nuclear Regulator's Role in Assessing Licensee Oversight of Vendor and Other Contracted Services

Canadian Nuclear Safety Commission's intern program

International Nuclear Information System (INIS)

Gilmour, P.E.

2002-01-01

The Intern Program was introduced at the Canadian Nuclear Safety Commission, Canada's Nuclear Regulator in response to the current competitive market for engineers and scientists and the CNSC's aging workforce. It is an entry level staff development program designed to recruit and train new engineering and science graduates to eventually regulate Canada's nuclear industry. The program provides meaningful work experience and exposes the interns to the general work activities of the Commission. It also provides them with a broad awareness of the regulatory issues in which the CNSC is involved. The intern program is a two-year program focusing on the operational areas and, more specifically, on the generalist functions of project officers. (author)

Comprehensive Plan for Public Confidence in Nuclear Regulator

International Nuclear Information System (INIS)

Choi, Kwang Sik; Choi, Young Sung; Kim, Ho ki

2008-01-01

Public confidence in nuclear regulator has been discussed internationally. Public trust or confidence is needed for achieving regulatory goal of assuring nuclear safety to the level that is acceptable by the public or providing public ease for nuclear safety. In Korea, public ease or public confidence has been suggested as major policy goal in the 'Nuclear regulatory policy direction' annually announced. This paper reviews theory of trust, its definitions and defines nuclear safety regulation, elements of public trust or public confidence developed based on the study conducted so far. Public ease model developed and 10 measures for ensuring public confidence are also presented and future study directions are suggested

Legislation on and regulation of nuclear activities

International Nuclear Information System (INIS)

1984-05-01

This work is a compilation of legislative texts and regulations published by the Atomic Energy Commission's Legal Affairs Department (CEA). It provides a comprehensive source of knowledge and information on nuclear energy law. Legislative texts published over the last forty years, are collected and analytically indexed. The publication covers both French regulations and regulations of international organisations such as the International Atomic Energy Agency and Euratom. It is divided into eight different chapters, dealing with regulations relevant to international and national institutions, nuclear installations, third party liability, protection of persons and the environment, etc. A chronological table of the texts of international and national laws is also included in this work. (NEA) [fr

The regulations concerning refining business of nuclear source material and nuclear fuel materials

International Nuclear Information System (INIS)

1979-01-01

The regulations are provided for under the law for the regulations of nuclear source materials, nuclear fuel materials and reactors and provisions concerning refining business in the enforcement order for the law. The basic concepts and terms are defined, such as: exposure dose, accumulative dose; controlled area; inspected surrounding area and employee. Refining facilities listed in the application for designation shall be classified into clushing and leaching, thickning, refining facilities, storage facilities of nuclear source materials and nuclear fuel materials, disposal facilities of contaminated substances and building for refining, etc. Business program attached to the application shall include expected time of beginning of refining, estimated production amount of nuclear source materials or nuclear fuel materials for the first three years and funds necessary for construction, etc. Records shall be made and kept for particular periods on delivery and storage of nuclear source materials and nuclear fuel materials, control of radiation, maintenance and accidents of refining facilities. Safety securing, application of internationally regulated substances and measures in dangerous situations are stipulated respectively. Exposure dose of employees and other specified matters shall be reported by the refiner yearly to the Director General of Science and Technology Agency and the Minister of International Trade and Industry. (Okada, K.)

The evolution of nuclear regulation

International Nuclear Information System (INIS)

Martin, A.

1997-01-01

The already not so young history of nuclear regulations shows patterns and specific causes that have characterized and influenced its own evolution as well as the industry itself. Today's regulation is facing relevant challenges with potential significant effects. The quest for higher regulatory efficiency brings up the increasing need to base future actions on firmly established strategies. (Author) 7 refs

Entry into the electricity market: Uncertainty, competition, and mothballing options

Energy Technology Data Exchange (ETDEWEB)

Takashima, Ryuta [Department of Nuclear Engineering and Management, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan)], E-mail: takashima@n.t.u-tokyo.ac.jp; Goto, Makoto [Department of Industrial and Management Systems Engineering, Waseda University, 3-4-1 Okubo, Shinjyuku-ku, Tokyo 169-8555 (Japan); Kimura, Hiroshi; Madarame, Haruki [Nuclear Professional School, University of Tokyo, 2-22 Shirane, Shirakata, Tokai-mura, Naka-Gun, Ibaraki-ken 319-1188 (Japan)

2008-07-15

The present paper analyzes the entry strategies into the electricity market of two firms that have power plants under price uncertainty and competition. We consider the symmetric and asymmetric two firms, which have either a thermal power plant or a nuclear power plant. The differences between the thermal power plant and the nuclear power plant, such as the cost structure and operational flexibility are modeled. The threshold values of market entry are calculated for each firm with either the thermal power plant or the nuclear power plant as the leader or the follower. We show the dependence of cost structures on entry thresholds of the leader and the follower into the electricity market. For various market and cost conditions, the diagrams of the leader are also shown.

Entry into the electricity market: Uncertainty, competition, and mothballing options

International Nuclear Information System (INIS)

Takashima, Ryuta; Goto, Makoto; Kimura, Hiroshi; Madarame, Haruki

2008-01-01

The present paper analyzes the entry strategies into the electricity market of two firms that have power plants under price uncertainty and competition. We consider the symmetric and asymmetric two firms, which have either a thermal power plant or a nuclear power plant. The differences between the thermal power plant and the nuclear power plant, such as the cost structure and operational flexibility are modeled. The threshold values of market entry are calculated for each firm with either the thermal power plant or the nuclear power plant as the leader or the follower. We show the dependence of cost structures on entry thresholds of the leader and the follower into the electricity market. For various market and cost conditions, the diagrams of the leader are also shown

The Regulation of Nuclear Trade: Non-Proliferation-Supply-safety

International Nuclear Information System (INIS)

1988-01-01

Volume II of the study on the regulation of nuclear trade deals with the national legislation of OECD countries with significant nuclear programmes and regulations in that field and, in essence, covers two aspects. The first concerns political and administrative controls over imports and exports of sensitive products, namely fissile materials and large nuclear equipment as well as technology transfers. In most cases, this description of the provisions applicable is completed with the list of nuclear items whose export is restricted. The second aspect concerns the licensing system governing trade in as well as the import and export of nuclear material to protect users and the public against the hazards created by its radioactive properties. This volume also contains information on regulations concerning physical protection, industrial property and transport, as well as on multilateral and bilateral agreements involving nuclear trade. (NEA) [fr

Nuclear safety regulations in the Republic of Croatia

International Nuclear Information System (INIS)

Cizmek, A.; Horvatic, M.; Ilijas, B.; Medakovic, S.

2009-01-01

Based on Nuclear Safety Act (Official Gazette No. 173/03) in 2006 State Office for Nuclear Safety (SONS) adopted beside Ordinance on performing nuclear activities (Official Gazette No. 74/06) and Ordinance on special conditions for individual activities to be performed by expert organizations which perform activities in the area of nuclear safety (Official Gazette No. 74/06) the new Ordinance on the control of nuclear material and special equipment (Official Gazette No. 15/08) and Ordinance on conditions for nuclear safety and protection with regard to the sitting, design, construction, use and decommissioning of a facility in which a nuclear activity is to be performed (Official Gazette No. 71/08). The Ordinance on performing nuclear activities regulates the procedure of notification of the intent to perform nuclear activities, submitting the application for the issue of a licence to perform nuclear activities, and the procedure for issuing decisions on granting a license to perform nuclear activity. The Ordinance also regulates the content of the form for notification of the intent to perform nuclear activities, as well as of the application for the issue of a licence to perform the nuclear activity and the method of keeping the register of nuclear conditions, whereas compliance is established by the decision passed by SONS. Ordinance on special conditions (requirements) for individual activities to be performed by expert organizations which perform activities in the area of nuclear safety regulates these mentioned activities Ordinance on the control of nuclear material and special equipment lays down the list of nuclear materials and special equipment as well as of nuclear activities covered by the system of control of production of special equipment and non-nuclear material, the procedure for notifying the intention to and filing the application for a licence to carry out nuclear activities, and the format and contents of the forms for doing so. This Ordinance

The politics of nuclear safety regulation

International Nuclear Information System (INIS)

Adam, G.

2002-01-01

The paper discusses political aspects of decision making about the safety of nuclear power plants especially in Eastern Europe and in connection with the enlargement of the European Union. The problem of the Kozloduy NPP safety is also discussed. Recommendations on the policy and tasks for nuclear regulators are given

CEQ regulations called peril to nuclear licensing process

International Nuclear Information System (INIS)

O'Neill, J.V.

1979-01-01

Court challenges are expected over regulations of the Council on Environmental Quality (CEQ) that were designed to improve nuclear-licensing decisions, but that have actually changed the meanings of National Environmental Policy Act (NEPA) regulations. The legal implications of these changes could, unless resolved, make the licensing process for nuclear facilities even more uncertain. Agency comments are thought to be critical, although the CEQ has declined to release them, and some question the Council's legality. The Nuclear Regulatory Commission faults the CEQ regulations for revising existing law, being inconsistent with the responsibilities of an independent regulatory body, and extending the CEQ's authority beyond the role assigned by NEPA and the President's Executive Order

The regulations concerning refining business of nuclear source material and nuclear fuel materials

International Nuclear Information System (INIS)

1981-01-01

This rule is established under the provisions concerning refining business in the law concerning the regulation of nuclear raw materials, nuclear fuel materials and nuclear reactors and the ordinance for the execution of this law, and to enforce them. Basic terms are defined, such as: exposure radiation dose, cumulative dose, control area, surrounding monitoring area and worker. The application for the designation for refining business under the law shall be classified into the facilities for crushing and leaching-filtration, thikening, and refining, the storage facilities for nuclear raw materials and nuclear fuel materials, and the disposal facilities for radioactive wastes, etc. To the application, shall be attached business plans, the explanations concerning the technical abilities of applicants and the prevention of hazards by nuclear raw materials and nuclear fuel materials regarding refining facilities, etc. Records shall be made on the accept, delivery and stock of each kind of nuclear raw materials and nuclear fuel materials, radiation control, the maintenance of and accidents in refining facilities, and kept for specified periods, respectively. Security regulations shall be enacted for each works or enterprise on the functions and organizations of persons engaged in the control of refining facilities, the operation of the apparatuses which must be controlled for the prevention of accidents, and the establishment of control area and surrounding monitoring area, etc. The report on the usage of internationally regulated goods and the measures taken at the time of danger are defined particularly. (Okada, K.)

International Nuclear Officials Discuss IAEA Peer Reviews of Nuclear Safety Regulations

International Nuclear Information System (INIS)

2011-01-01

Full text: Senior nuclear regulators today concluded a Workshop on the Lessons Learned from the IAEA Integrated Regulatory Review Service (IRRS) Missions. The U.S. Nuclear Regulatory Commission (NRC) hosted the workshop, in cooperation with the International Atomic Energy Agency, in Washington, DC, from 26 to 28 October 2011. About 60 senior regulators from 22 IAEA Member States took part in this workshop. The IRRS programme is an international peer review service offered by the IAEA to its Member States to provide an objective evaluation of their nuclear safety regulatory framework. The review is based on the internationally recognized IAEA Safety Standards. ''The United States Nuclear Regulatory Commission was pleased to host the IAEA's IRRS meeting this week. The discussions over the past three days have provided an important opportunity for regulators from many countries to come together to strengthen the international peer review process,'' said U.S. NRC Chairman Gregory B. Jaczko. ''Especially after the Fukushima Daiichi accident, the global community recognizes that IRRS missions fill a vital role in strengthening nuclear safety and security programs around the world, and we are proud to be a part of this important effort.'' The IAEA Action Plan on Nuclear Safety includes actions focused towards strengthening the existing IAEA peer reviews, incorporating lessons learned and improving their effectiveness. The workshop provided a platform for the exchange of information, experience and lessons learned from the IRRS missions, as well as expectations for the IRRS programme for the near future. Further improvements in the planning and implementation of the IRRS missions in the longer term were discussed. A strong commitment of all relevant national authorities to the IRRS programme was identified as a key element of an effective regulatory framework. The conclusions of the workshop will be issued in November 2011 and the main results will be reported to the IAEA

Economic consideration of nuclear safety and cost benefit analysis in nuclear safety regulation

International Nuclear Information System (INIS)

Choi, Y. S.; Choi, K. S.; Choi, K. W.; Song, I. J.; Park, D. K.

2001-01-01

For the optimization of nuclear safety regulation, understanding of economic aspects of it becomes increasingly important together with the technical approach used so far to secure nuclear safety. Relevant economic theories on private and public goods were reviewed to re-illuminate nuclear safety from the economic perspective. The characteristics of nuclear safety as a public good was reviewed and discussed in comparison with the car safety as a private safety good. It was shown that the change of social welfare resulted from the policy change induced can be calculated by the summation of compensating variation(CV) of individuals. It was shown that the value of nuclear safety could be determined in monetary term by this approach. The theoretical background and history of cost benefit analysis of nuclear safety regulation were presented and topics for future study were suggested

Legislation for the countermeasures on special issues of nuclear safety regulations

International Nuclear Information System (INIS)

Cho, Byung Sun; Lee, Mo Sung; Chung, Gum Chun; Kim, Hak Man; Oh, Ho Chul

2003-02-01

Since the present legal system on nuclear safety regulation has some problems that refer to contents of regulatory provisions, this mid-report has preformed research on the legal basic theory of nuclear safety regulation. And then secondly this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation. In order to interpret easily this report finally took the cases of judicial precedents on nuclear safety regulation in USA, Germany, Japan and Korea

Legislation for the countermeasures on special issues of nuclear safety regulations

Energy Technology Data Exchange (ETDEWEB)

Cho, Byung Sun; Lee, Mo Sung; Chung, Gum Chun; Kim, Hak Man; Oh, Ho Chul [Chongju Univ., Cheongju (Korea, Republic of)

2003-02-15

Since the present legal system on nuclear safety regulation has some problems that refer to contents of regulatory provisions, this mid-report has preformed research on the legal basic theory of nuclear safety regulation. And then secondly this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation. In order to interpret easily this report finally took the cases of judicial precedents on nuclear safety regulation in USA, Germany, Japan and Korea.

Steps towards Nuclear Power Regulator in Kenya

International Nuclear Information System (INIS)

Gatebe, E.

2017-01-01

The first radiation protection law in Kenya was passed in 1948 and it was referred to as the''Radiological Protection Ordinance -1948''. The ordinance established the Radiological Protection Board (RPB). The current law is the Radiation Protection Act, Cap 243.that was amended in 2014. To regulate the peaceful use of atomic energy through provision of nuclear safety and security culture for the protection of persons, society and the environment against radiation. The Establishment of Nuclear Electricity Project Committee in 2010 is Predecessor of KNEB (2012). Whose mandate among others: Assist in coming up with a legalisation and regulatory framework for support of nuclear power. Human resource development for support of Nuclear Power programme. The country hosted Integrated Nuclear Infrastructure Review (INIR) and Integrated Regulatory Review Service (IRRS) Missions in 2015 and 2016 respectively to addressed legal and regulatory framework. A Multi-agency cooperation has resulted to the Nuclear Regulatory Bill. The Government has been sponsoring 15 students annually for post graduate studies in Nuclear Science at University of Nairobi. IAEA has been a great partner in the development of Kenya's nuclear regulatory regime; It is expected that in the next two years, Kenya will have the core capacity for regulating a nuclear power program. The Bill has taken into consideration suggestions and recommendation of the INIR & IRRS Missions, and comments from the office of Legal Affairs-IAEA and local stakeholders

Regulations concerning the fabricating business of nuclear fuel materials

International Nuclear Information System (INIS)

1978-01-01

The Regulation is revised on the basis of ''The law for the regulations of nuclear source materials, nuclear fuel materials and reactors'' and the ''Provisions concerning the enterprises processing nuclear fuel materials'' in the Enforcement Ordinance for the Law, to enforce such provisions. This is the complete revision of the regulation of the same name in 1957. Terms are explained, such as exposure radiation dose, cumulative dose, control area, surrounding inspection area, persons engaged in works, radioactive wastes, area for incoming and outgoing of materials, fluctuation of stocks, batch, real stocks, effective value and main measuring points. For the applications for the permission of the enterprises processing nuclear fuel materials, the location of an enterprise, the construction of buildings and the construction of and the equipments for facilities of chemical processing, forming, coating, assembling, storage of nuclear fuel materials, disposal of radioactive wastes and radiation control must be written. Records shall be made and maintained for the periods specified on the inspection of processing facilities, nuclear fuel materials, radiation control, operation, maintainance, accidents of processing facilities and weather. Limit to entrance into the control area, measures for exposure radiation dose, patrol and inspection, operation of processing facilities, transport of materials, disposal of radioactive wastes, safety regulations are provided for. Reports to be filed by the persons engaging in the enterprises processing nuclear fuel materials are prescribed. (Okada, K.)

The law for the regulations of nuclear source materials, nuclear fuel materials and reactors

International Nuclear Information System (INIS)

1980-01-01

The law intends under the principles of the atomic energy act to regulate the refining, processing and reprocessing businesses of nuclear raw and fuel metarials and the installation and operation of reactors for the peaceful and systematic utilization of such materials and reactors and for securing public safety by preventing disasters, as well as to control internationally regulated things for effecting the international agreements on the research, development and utilization of atomic energy. Basic terms are defined, such as atomic energy; nuclear fuel material; nuclear raw material; nuclear reactor; refining; processing; reprocessing; internationally regulated thing. Any person who is going to engage in refining businesses other than the Power Reactor and Nuclear Fuel Development Corporation shall get the special designation by the Prime Minister and the Minister of International Trade Industry. Any person who is going to engage in processing businesses shall get the particular admission of the Prime Minister. Any person who is going to establish reactors shall get the particular admission of the Prime Minister, The Minister of International Trade and Industry or the Minister of Transportation according to the kinds of specified reactors, respectively. Any person who is going to engage in reprocessing businesses other than the Power Reactor and Nuclear Fuel Development Corporation and the Japan Atomic Energy Research Institute shall get the special designation by the Prime Minister. The employment of nuclear fuel materials and internationally regulated things is defined in detail. (Okada, K.)

Strategy for public understanding and participation in nuclear safety regulation

Energy Technology Data Exchange (ETDEWEB)

Kim, H. J.; Chung, Yun Hyung

2004-02-15

The objective of this study is to help the general public and local residents to better understand and trust nuclear safety regulation. In order to obtain public confidence in nuclear safety regulation, the emotion and demand of public should be first understood and the change in an attitude to meet the present circumstances actively is requisite. Hence it is intended that a genuine communication shall be newly arranged and accomplished on the basis of mutual understanding. To achieve this, a series of public opinion poll have performed periodically and symposium for the public acceptance is held in order to frame a policy based on the understanding of nuclear safety and regulation of the general public and local residents. Besides nuclear safety indicators including safety sentiment indicators are being developed as a means to understand the safety of operating nuclear power plants from the viewpoint of the general public, a plan for the harmonious communication of nuclear safety information is established, and handbooks of nuclear terminologies and report-writing are under development in part. Finally plans for convergence of the public opinions and a wide public involvement in nuclear safety regulation are formulated and their applicability as organization and administration program is now under consideration.

Limit regulation system for pressurized water nuclear reactors

International Nuclear Information System (INIS)

Aleite, W.; Bock, H.W.

1976-01-01

Described is a limit regulation system for a pressurized water nuclear reactor in combination with a steam generating system connected to a turbine, the nuclear reactor having control rods as well as an operational regulation system and a protective system, which includes reactor power limiting means operatively associated with the control rods for positioning the same and having response values between operating ranges of the operational regulation system, on the one hand, and response values of the protective system, on the other hand, and a live steam-minimal pressure regulation system cooperating with the reactor power limiting means and operatively connected to a steam inlet valve to the turbine for controlling the same

Legislation for the countermeasures on special issues of nuclear safety regulations

International Nuclear Information System (INIS)

Cho, Byung Sun; Lee, Mo Sung; Chung, Gum Chun; Kim, Heon Jin; Oh, Ho Chul

2004-02-01

Since the present nuclear safety regulation has some legal problems that refer to special issues and contents of regulatory provisions, this report has preformed research on the legal basic theory of nuclear safety regulation to solve the problems. In addition, this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation

Legislation for the countermeasures on special issues of nuclear safety regulations

Energy Technology Data Exchange (ETDEWEB)

Cho, Byung Sun; Lee, Mo Sung; Chung, Gum Chun; Kim, Heon Jin; Oh, Ho Chul [Chongju Univ., Cheongju (Korea, Republic of)

2004-02-15

Since the present nuclear safety regulation has some legal problems that refer to special issues and contents of regulatory provisions, this report has preformed research on the legal basic theory of nuclear safety regulation to solve the problems. In addition, this report analyzed the problems of each provisions and suggested the revision drafts on the basis of analyzing problems and the undergoing theory of nuclear safety regulation.

Nuclear entry of poliovirus protease-polymerase precursor 3CD: implications for host cell transcription shut-off

International Nuclear Information System (INIS)

Sharma, Rakhi; Raychaudhuri, Santanu; Dasgupta, Asim

2004-01-01

Host cell transcription mediated by all three RNA polymerases is rapidly inhibited after infection of mammalian cells with poliovirus (PV). Both genetic and biochemical studies have shown that the virus-encoded protease 3C cleaves the TATA-binding protein and other transcription factors at glutamine-glycine sites and is directly responsible for host cell transcription shut-off. PV replicates in the cytoplasm of infected cells. To shut-off host cell transcription, 3C or a precursor of 3C must enter the nucleus of infected cells. Although the 3C protease itself lacks a nuclear localization signal (NLS), amino acid sequence examination of 3D identified a potential single basic type NLS, KKKRD, spanning amino acids 125-129 within this polypeptide. Thus, a plausible scenario is that 3C enters the nucleus in the form of its precursor, 3CD, which then generates 3C by auto-proteolysis ultimately leading to cleavage of transcription factors in the nucleus. Using transient transfection of enhanced green fluorescent protein (EGFP) fusion polypeptides, we demonstrate here that both 3CD and 3D are capable of entering the nucleus in PV-infected cells. However, both polypeptides remain in the cytoplasm in uninfected HeLa cells. Mutagenesis of the NLS sequence in 3D prevents nuclear entry of 3D and 3CD in PV-infected cells. We also demonstrate that 3CD can be detected in the nuclear fraction from PV-infected HeLa cells as early as 2 h postinfection. Significant amount of 3CD is found associated with the nuclear fraction by 3-4 h of infection. Taken together, these results suggest that both the 3D NLS and PV infection are required for the entry of 3CD into the nucleus and that this may constitute a means by which viral protease 3C is delivered into the nucleus leading to host cell transcription shut-off

Nuclear regulation in Australia - future possibilities

International Nuclear Information System (INIS)

Carlson, J.; Bardsley, J.

1997-01-01

Australia's current nuclear regulatory arrangements reflect two major factors: that we are a federation, with a constitutional division of powers between the Commonwealth and the States, and that we have no nuclear industry, other than uranium mining. Australia's only nuclear facilities are operated by a Commonwealth instrumentality, ANSTO. Current Commonwealth regulatory arrangements are a response to international treaty commitments -principally the NPT (Treaty on the Non-Proliferation of Nuclear Weapons) -and to the commencement of commercial uranium mining and export in the late 1970's. Although at present no nuclear industry activities, other than mining, are in prospect, this might not always be the case, and with the establishment of ARPANSA (the Australian Radiation Protection and Nuclear Safety Agency) it is timely to give some thought to regulatory arrangements which might be appropriate to Australia's future circumstances. This paper will discuss the regulation activities relating to the nuclear fuel cycle , i e activities involved with the production and use of nuclear materials (uranium, thorium and plutonium) for the generation of energy through nuclear fission

Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells

Science.gov (United States)

Lombardi, Maria; Castoria, Gabriella; Migliaccio, Antimo; Barone, Maria Vittoria; Di Stasio, Rosina; Ciociola, Alessandra; Bottero, Daniela; Yamaguchi, Hiroshi; Appella, Ettore; Auricchio, Ferdinando

2008-01-01

In breast cancer cells, cytoplasmic localization of the estradiol receptor α (ERα) regulates estradiol-dependent S phase entry. We identified a nuclear export sequence (NES) in ERα and show that its export is dependent on both estradiol-mediated phosphatidylinositol-3-kinase (PI3K)/AKT activation and chromosome region maintenance 1 (CRM1). A Tat peptide containing the ERα NES disrupts ERα–CRM1 interaction and prevents nuclear export of ERα- and estradiol-induced DNA synthesis. NES-ERα mutants do not exit the nucleus and inhibit estradiol-induced S phase entry; ERα-dependent transcription is normal. ERα is associated with Forkhead proteins in the nucleus, and estradiol stimulates nuclear exit of both proteins. ERα knockdown or ERα NES mutations prevent ERα and Forkhead nuclear export. A mutant of forkhead in rhabdomyosarcoma (FKHR), which cannot be phosphorylated by estradiol-activated AKT, does not associate with ERα and is trapped in the nucleus, blocking S phase entry. In conclusion, estradiol-induced AKT-dependent phosphorylation of FKHR drives its association with ERα, thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry. PMID:18644889

Legal issues in amending nuclear rules and regulations

International Nuclear Information System (INIS)

Ossenbuehl, F.

2006-01-01

Nuclear rules and regulations are composed of a multitude of provisions, benchmarks, etc. of different origins and different levels of legal quality. The Safety Criteria and Guidelines for Nuclear Power Plants published in the 'Bundesanzeiger' (Federal Gazette) by the competent federal ministry after consultation of the competent highest state authorities are of particular importance. The Safety Criteria were adopted by the States Committee for Atomic Energy on October 12, 1977 and published in the 'Bundesanzeiger'. The Federal Ministry for the Environment, Nature Conservation, and Nuclear Safety (BMU) intends to revise and amend the contents of the safety criteria and guidelines applying to nuclear power plants. The question underlying this article is this: In what legal way can such an 'amendment' be achieved in a permissible fashion? This leaves out of consideration the question of the contents and applicability of amended provisions, such as the question to what extent amended regulations can also be applied to the nuclear power plants already licensed and in operation, or whether the concept of finality and the constitutional ban on retroactive effect or other constitutional or paramount rules contain restrictions on the contents of such regulations. Solely the question of a permissible amending procedure is under study. (orig.)

Regulation and quality in nuclear medicine 2 october 1998

International Nuclear Information System (INIS)

Kouchner, B.; Huriet, C.; Le Deaut, J.Y.

1999-01-01

The aim of this meeting is to examine how the regulations are liable to decrease the patient taking charge. The problem of the public information and opinion in the nuclear medicine domain is also presented. The nineteen presentations are proposed in 2 sessions. The first one deals with the state of the art of the nuclear medicine in France (techniques and regulations). The second one deals with the environment of the nuclear medicine (irradiation limits, public opinion, doctors and medicine quality). (A.L.B.)

Leadership for Safety in Practice: Perspectives from a Nuclear Regulator

International Nuclear Information System (INIS)

Tyobeka, B. M.

2016-01-01

The principal responsibility for a nuclear regulator is to assure compliance with regulations and safety standards by operators. One of these requirements is demonstration of, and adherence to, nuclear safety culture by the operators. At the same time, the regulators themselves are expected to live the talk and practice what they preach, i.e., demonstrate highest levels of nuclear safety culture within their organizations. Consequently, it is recognised that leadership is important in the creation of a culture that supports and promotes a strong nuclear safety performance of an organization. The leaders of a regulatory body are vital in inspiring employees to a higher level of safety and productivity, which means that they must apply good leadership attributes on a daily basis. This paper will attempt to bring forth and share attributes for strong leadership role in promoting a safety culture within a nuclear regulatory body by surveying world-wide practices and examples in developing and advanced nuclear countries. (author)

Nuclear localization signal regulates porcine circovirus type 2 capsid protein nuclear export through phosphorylation.

Science.gov (United States)

Hou, Qiang; Hou, Shaohua; Chen, Qing; Jia, Hong; Xin, Ting; Jiang, Yitong; Guo, Xiaoyu; Zhu, Hongfei

2018-02-15

The open reading frame 2 (ORF2) of Porcine circovirus type 2 (PCV2) encodes the major Capsid (Cap) protein, which self-assembles into virus-like particle (VLP) of similar morphology to the PCV2 virion and accumulates in the nucleus through the N-terminal arginine-rich nuclear localization signal (NLS). In this study, PCV2 Cap protein and its derivates were expressed via the baculovirus expression system, and the cellular localization of the recombinant proteins were investigated using anti-Cap mAb by imaging flow cytometry. Analysis of subcellular localization of Cap protein and its variants demonstrated that NLS mediated Cap protein nuclear export as well as nuclear import, and a phosphorylation site (S17) was identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the NLS domain to regulate Cap protein nuclear export. Phosphorylation of NLS regulating the PCV2 Cap protein nuclear export was also demonstrated in PK15 cells by fluorescence microscopy. Moreover, the influence of Rep and Rep' protein on Cap protein subcellular localization was investigated in PK15 cells. Phosphorylation of NLS regulating Cap protein nuclear export provides more detailed knowledge of the PCV2 viral life cycle. Copyright © 2018 Elsevier B.V. All rights reserved.

A study in improvement of administrative system in the nuclear safety regulation

International Nuclear Information System (INIS)

Yook, Dong Il; Kuk, Doe Hyeong; Lee, Seong Min; Kim, Jong Sam; Hwang, Sun Ho

2001-03-01

One of the most important tasks to improve nuclear safety regulation system is to separate nuclear regulatory institutes from public agencies which promote the development nuclear power. Moreover, nuclear safety regulation should be not only specialized but optimized to be adapted for new environments such as high-tech information age. Especially, it is necessary to reform the current nuclear safety regulation systems both to be effective under the local self-administration which began to operate in recent years and to be supported by local residents

A study in improvement of administrative system in the nuclear safety regulation

Energy Technology Data Exchange (ETDEWEB)

Yook, Dong Il; Kuk, Doe Hyeong; Lee, Seong Min; Kim, Jong Sam; Hwang, Sun Ho [Chungnam National Univ., Taejon (Korea, Republic of)

2001-03-15

One of the most important tasks to improve nuclear safety regulation system is to separate nuclear regulatory institutes from public agencies which promote the development nuclear power. Moreover, nuclear safety regulation should be not only specialized but optimized to be adapted for new environments such as high-tech information age. Especially, it is necessary to reform the current nuclear safety regulation systems both to be effective under the local self-administration which began to operate in recent years and to be supported by local residents.

Review of Policy Documents for Nuclear Safety and Regulation

International Nuclear Information System (INIS)

Kim, Woong Sik; Choi, Kwang Sik; Choi, Young Sung; Kim, Hho Jung; Kim, Ho Ki

2006-01-01

The goal of regulation is to protect public health and safety as well as environment from radiological hazards that may occur as a result of the use of atomic energy. In September 1994, the Korean government issued the Nuclear Safety Policy Statement (NSPS) to establish policy goals of maintaining and achieving high-level of nuclear safety and also help the public understand the national policy and a strong will of the government toward nuclear safety. It declares the importance of establishing safety culture in nuclear community and also specifies five nuclear regulatory principles (Independence, Openness, Clarity, Efficiency and Reliability) and provides the eleven regulatory policy directions. In 2001, the Nuclear Safety Charter was declared to make the highest goal of safety in driving nuclear business clearer; to encourage atomic energy- related institutions and workers to keep in mind the mission and responsibility for assuring safety; to guarantee public confidence in related organizations. The Ministry of Science and Technology (MOST) also issues Yearly Regulatory Policy Directions at the beginning of every year. Recently, the third Atomic Energy Promotion Plan (2007-2011) has been established. It becomes necessary for the relevant organizations to prepare the detailed plans on such areas as nuclear development, safety management, regulation, etc. This paper introduces a multi-level structure of nuclear safety and regulation policy documents in Korea and presents some improvements necessary for better application of the policies

Review of Policy Documents for Nuclear Safety and Regulation

Energy Technology Data Exchange (ETDEWEB)

Kim, Woong Sik; Choi, Kwang Sik; Choi, Young Sung; Kim, Hho Jung; Kim, Ho Ki [Korea Institute of Nuclear Safety, Taejon (Korea, Republic of)

2006-07-01

The goal of regulation is to protect public health and safety as well as environment from radiological hazards that may occur as a result of the use of atomic energy. In September 1994, the Korean government issued the Nuclear Safety Policy Statement (NSPS) to establish policy goals of maintaining and achieving high-level of nuclear safety and also help the public understand the national policy and a strong will of the government toward nuclear safety. It declares the importance of establishing safety culture in nuclear community and also specifies five nuclear regulatory principles (Independence, Openness, Clarity, Efficiency and Reliability) and provides the eleven regulatory policy directions. In 2001, the Nuclear Safety Charter was declared to make the highest goal of safety in driving nuclear business clearer; to encourage atomic energy- related institutions and workers to keep in mind the mission and responsibility for assuring safety; to guarantee public confidence in related organizations. The Ministry of Science and Technology (MOST) also issues Yearly Regulatory Policy Directions at the beginning of every year. Recently, the third Atomic Energy Promotion Plan (2007-2011) has been established. It becomes necessary for the relevant organizations to prepare the detailed plans on such areas as nuclear development, safety management, regulation, etc. This paper introduces a multi-level structure of nuclear safety and regulation policy documents in Korea and presents some improvements necessary for better application of the policies.

Building, measuring and improving public confidence in the nuclear regulator

International Nuclear Information System (INIS)

2006-01-01

An important factor for public confidence in the nuclear regulator is the general public trust of the government and its representatives, which is clearly not the same in all countries. Likewise, cultural differences between countries can be considerable, and similar means of communication between government authorities and the public may not be universally effective. Nevertheless, this workshop identified a number of common principles for the communication of nuclear regulatory decisions that can be recommended to all regulators. They have been cited in particular for their ability to help build, measure and/or improve overall public confidence in the nuclear regulator. (author)

Public opinion poll on safety and regulations of nuclear energy

Energy Technology Data Exchange (ETDEWEB)

Park, M. I.; Park, B. I.; Lee, S. M. [Gallup Korea, Seoul (Korea, Republic of)

2004-02-15

The purpose of this poll is not only to research understanding on safety and regulations of nuclear energy and to compare the result by time series followed 2003 to 2002 years, also to establish the public relations strategies and to offer information for developing long-term policies. The contents of the study are on the general perception, safety, management of nuclear power station, regulations and surroundings about nuclear energy.

Statement to the Third Conference on Facilitating the Entry into Force of the Comprehensive Nuclear-Test-Ban Treaty (CTBT). Vienna, 3 September 2003

International Nuclear Information System (INIS)

ElBaradei, M.

2003-01-01

Full text: The Third Conference on Facilitating the Entry into Force of the Comprehensive Nuclear-Test-Ban Treaty (CTBT) is being held at a time of major challenges to the nuclear arms control and disarmament regime. A verified, permanent, global ban on all types of nuclear explosive tests has been a key item on the international security agenda for nearly half a century. More than 2,000 nuclear explosive detonations have taken place since 1945, with the most recent ones in 1998. The CTBT has been characterized as the longest sought, hardest fought prize in the history of arms control. The Treaty, when implemented, will prohibit all nuclear explosions, in all environments, for all time. It will curb the development and testing of new, more advanced and more dangerous nuclear weapons, and will limit the possibilities for further nuclear proliferation. The Treaty will lead to the establishment of a comprehensive International Monitoring System to provide independent, impartial verification of compliance. The CTBT, along with the Treaty on the Non-Proliferation of Nuclear Weapons (NPT), and a future Treaty Banning the Production of Fissile Material for Nuclear Weapons and Other Nuclear Explosive Devices (FMCT), forms an essential element of a network of negotiated, global treaties that will strengthen international efforts to prevent the further spread of nuclear weapons and to promote nuclear disarmament leading in time hopefully to a world without nuclear weapons. In the meantime, with the early entry into force of the CTBT, it would indeed be a significant achievement if this new century were to remain free of any nuclear test explosions. In this context, I encourage all signatory States to ratify the CTBT, and all those States that have yet to sign to do so and to ratify the Treaty, as soon as possible - so that another crucial pillar can be raised to support the edifice of global nuclear non-proliferation and nuclear disarmament norms. (IAEA)

Special feature article. Nuclear new age. Towards reform of laws and regulations

International Nuclear Information System (INIS)

Madarame, Haruki; Morokuzu, Muneo; Shiroyama, Hideaki; Nishiwaki, Yoshihiro; Marumo, Syunji; Suzuki, Takahiro; Hariyama, Hideo

2007-01-01

Since about half a century passes after the peaceful use of nuclear energy began in Japan, the safety laws and regulations of the nuclear energy becomes difficult to cope enough with the current situation without regulation structure changing. In March 2007, Tokyo University set up nuclear energy legislation study meeting' consisting of members from regulatory bodies, electric utilities, nuclear industries and others. The special feature introduces five opinions obtained through the argument in the meeting. As an example, Law for the Regulations of Nuclear Sources Material, Nuclear Fuel Material and Reactors is applied to basic design about the commercial reactors, but Electric Utilities Industry Law is applied to a detailed design, and different licensing standard is applied in each. Taking the adjustment of licensing standard with unifying these is necessary for efficiency. In addition, current law for the Regulations of Nuclear Sources Material, Nuclear Fuel Material and Reactors regulates according to the businesses such as reactor facilities, fuel fabrication plants and radioactive waste disposal. As for plural businesses, a low procedure and safety measures are demanded every each business. It is also necessary to include structure of the comprehensive licensing that assumed an enterprise running plural businesses. (T. Tanaka)

A switch from a gradient to a threshold mode in the regulation of a transcriptional cascade promotes robust execution of meiosis in budding yeast.

Directory of Open Access Journals (Sweden)

Vyacheslav Gurevich

Full Text Available Tight regulation of developmental pathways is of critical importance to all organisms, and is achieved by a transcriptional cascade ensuring the coordinated expression of sets of genes. We aimed to explore whether a strong signal is required to enter and complete a developmental pathway, by using meiosis in budding yeast as a model. We demonstrate that meiosis in budding yeast is insensitive to drastic changes in the levels of its consecutive positive regulators (Ime1, Ime2, and Ndt80. Entry into DNA replication is not correlated with the time of transcription of the early genes that regulate this event. Entry into nuclear division is directly regulated by the time of transcription of the middle genes, as premature transcription of their activator NDT80, leads to a premature entry into the first meiotic division, and loss of coordination between DNA replication and nuclear division. We demonstrate that Cdk1/Cln3 functions as a negative regulator of Ime2, and that ectopic expression of Cln3 delays entry into nuclear division as well as NDT80 transcription. Because Ime2 functions as a positive regulator for premeiotic DNA replication and NDT80 transcription, as well as a negative regulator of Cdk/Cln, we suggest that a double negative feedback loop between Ime2 and Cdk1/Cln3 promotes a bistable switch from the cell cycle to meiosis. Moreover, our results suggest a regulatory mode switch that ensures robust meiosis as the transcription of the early meiosis-specific genes responds in a graded mode to Ime1 levels, whereas that of the middle and late genes as well as initiation of DNA replication, are regulated in a threshold mode.

Search for greater stability in nuclear regulation

International Nuclear Information System (INIS)

Asselstine, J.K.

1985-01-01

The need for greater stability in nuclear regulation is discussed. Two possible approaches for dealing with the problems of new and rapidly changing regulatory requirements are discussed. The first approach relies on the more traditional licensing reform initiatives that have been considered off and on for the past decade. The second approach considers a new regulator philosophy aimed at the root causes of the proliferation of new safety requirements that have been imposed in recent years. For the past few years, the concepts of deregulation and regulatory reform have been in fashion in Washington, and the commercial nuclear power program has not remained unaffected. Many look to these concepts to provide greater stability in the regulatory program. The NRC, the nuclear industry and the administration have all been avidly pursuing regulatory reform initiatives, which take the form of both legislative and administrative proposals. Many of these proposals look to the future, and, if adopted, would have little impact on currently operating nuclear power plants or plants now under construction

50 CFR 660.24 - Limited entry and open access fisheries.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Limited entry and open access fisheries... Groundfish Fisheries § 660.24 Limited entry and open access fisheries. (a) General. All commercial fishing for groundfish must be conducted in accordance with the regulations governing limited entry and open...

Nuclear safety: risks and regulation

International Nuclear Information System (INIS)

Wood, W.C.

1983-01-01

Taking a fresh look at nuclear safety regulations, this study finds that the mandate and organization of the Nuclear Regulatory Commission (NRC) militate against its making sound decisions. The author criticizes failures to make hard decisions on societal risk, to clarify responsibility, and to implement cost-effective safety measures. Among his recommendations are reorganization of the NRC under a single authoritative administrator, separation of technical issues from social ones, and reform of the Price-Anderson Act. The author concludes that the worst eventuality would be to continue the current state of indecision. 161 references, 6 figures, 4 tables

Managing and regulating organisational change in nuclear installations

International Nuclear Information System (INIS)

Pyy, P.; Reiersen, C.

2004-01-01

To the extent that organisational change in nuclear installations can potentially impact nuclear safety, it is imperative to ensure that such change is property managed and regulated. A number of key elements can help achieve successful management of change. (author)

The Swedish Nuclear Power Inspectorate's Regulations concerning Safety in connection with the Disposal of Nuclear Material and Nuclear Waste. General Recommendations concerning the Application of the Swedish Nuclear Power Inspectorate's Regulations above

International Nuclear Information System (INIS)

2002-06-01

An english translation of the original Swedish regulations concerning the safety in disposal of nuclear wastes is published in this booklet, together with recommendations on how these regulations can be applied

Legal principles of regulatory administration and nuclear safety regulation

Energy Technology Data Exchange (ETDEWEB)

Lee, Kyeong Hui; Cheong, Sang Kee [Hannam Univ., Taejon (Korea, Republic of)

2000-12-15

This research presents a critical analysis and evaluation of principles of administrative laws in order to provide framework of structural reform on the nuclear safety regulation system. The focus of this analysis and evaluation is centered around the area of origin of regulatory administrative laws; authorities of regulation; procedures of regulatory actions; regulatory enforcement; and administrative relief system. In chapter 2 the concept of regulatory administration is analysed. Chapter 3 identifies the origin of regulatory administration and the principles of administration laws. It also examines legal nature of the nuclear safety standard. In relation to regulatory authorities. Chapter 4 identifies role and responsibility of administration authorities and institutions. It also examines fundamental principles of delegation of power. Then the chapter discusses the nuclear safety regulation authorities and their roles and responsibilities. Chapter 5 classifies and examines regulatory administration actions. Chapter 6 evaluates enforcement measure for effectiveness of regulation. Finally, chapter 7 discusses the administrative relief system for reviewing unreasonable regulatory acts.

8 CFR 234.4 - International airports for entry of aliens.

Science.gov (United States)

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false International airports for entry of aliens. 234.4 Section 234.4 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS DESIGNATION OF PORTS OF ENTRY FOR ALIENS ARRIVING BY CIVIL AIRCRAFT § 234.4 International airports for entry...

Duty and role of Nuclear Regulation Authority facing a crucial moment

International Nuclear Information System (INIS)

Asaoka, Mie

2013-01-01

Duty of Nuclear Regulation Authority (NRA) was to restore public trust on nuclear regulation spoiled by the Fukushima nuclear accident. How applied such regulation as mandatory back-fitting based on latest knowledge and 40 year operational limit in principle became of great concern. Active faults issue on existing nuclear power station could be a touchstone. Safety side judgment and electric utilities side's proof responsibilities were required as more stringent criteria for active faults. The expert group had been working on assessment of fracture zones under the field survey. Reform of safety regulations should be done based on three important standpoints: (1) not business easiness but public safety was first (2) NRA keeping stance to judge its own safety standard and how NRA ought to be and (3) importance of public disclosure of information and participation in decision-making judging from greatness of public effects caused by nuclear disaster. (T. Tanaka)

Development of Comprehensive Nuclear Safety Regulation Plan for 2007-2011

International Nuclear Information System (INIS)

Choi, Young Sung; Kim, Woong Sik; Park, Dong Keuk; Kim, Ho Ki

2006-01-01

The Article 8-2 of Atomic Energy Act requires the government to establish Atomic Energy Promotion Plan every five years. It sets out national nuclear energy policies in a systematic and consistent way. The plan presents the goals and basic directions of national nuclear energy policies on the basis of current status and prospects. Both areas of utilization and safety management of nuclear energy are included and various projects and schedules are delineated based on the national policy directions. The safety management area in this plan deals with the overall safety and regulation policy. Its detail projects and schedule should be developed in separate plans by responsible ministries under the mediation of the MOST. As a regulatory authority, MOST is responsible for safety management area and its technical support organization, KINS has developed Comprehensive Nuclear Safety Regulation Plan as an implementation plan of safety area. This paper presents the development process and specific projects contained in the Comprehensive Nuclear Safety Regulation Plan which is under development now

The experience on public consultation in the elaboration of nuclear regulations

International Nuclear Information System (INIS)

Monteiro, Iara A.; Pitta, Maria Adelia R.; Pereira, Enneite S.; Wieland, Patricia

2009-01-01

This paper presents and discusses the process of public consultation followed by the regulatory body, Nuclear Energy National Commission (CNEN), during the elaboration of nuclear regulations. In this paper, the due legislation on federal administration, law n. 9784/99, is referred to and the procedures established by CNEN for the elaboration of a nuclear regulation are described. The public consultation has the objective of improving the democratization of nuclear regulations elaboration process, allowing the participation of interested parties such as professional associations directly involved, organizations interested in its application and the general public. During the process of elaboration of a nuclear regulation, the basic text is, first of all, discussed and improved by a task group. This group is composed by CNEN's officials and representatives of organizations, enterprises and public agencies involved in the related area. Once the first version of the proposed regulation is ready, it is formally open to consultation and posted at CNEN website for a period of time. The suggestions, therein presented on-line, are analyzed by the task group and the conclusions are also posted at the site; those considered pertinent are incorporated to proposed regulation. As an example, the public consultation results obtained in 2008 with the revision of the CNEN-NN-6.02: Licensing of Radioactive Facilities regulation, are presented. Such results cover two aspects: the analysis of the participants profile and the analysis of the contributions. Public participation in the elaboration of nuclear regulations is a new way for CNEN to know the licensees and public demands, doubts and needs. This tool has demonstrated usefulness and therefore must be maintained by the regulatory body. (author)

Regulation of nuclear power in the UK after Chernobyl

International Nuclear Information System (INIS)

Ryder, E.A.

1987-01-01

The essential philosophy underlying safe nuclear power in the UK is to establish a safe design and then monitor the manufacture, construction, commissioning, operation and maintenance to ensure that the safe design intent is not violated either deliberately or unintentionally. In the UK any commercial nuclear installation must have a nuclear site licence. The Nuclear Installations Inspectorate (NII) is the agency responsible for granting licences and ensuring the safe design and operation of the installation by the licensee. The way in which the NII does this for the 27 licensed sites that it regulates in the UK is explained. This covers plant assessment and site inspection. Following the accident at Chernobyl the NII reviewed the way in which it regulates nuclear power in the UK. Some changes in specific areas were recommended but no changes in the general philosophy were considered necessary. (UK)

The UK nuclear regulator's view of external influences on safety

International Nuclear Information System (INIS)

Summers, J.L.

2001-01-01

Over the past forty or so years, significant changes have taken place in the UK nuclear industry and the pace of change is continually increasing. As a consequence, the Nuclear Installations Inspectorate (NII), the UK's nuclear regulator, has also had to change. This paper describes some of the challenges to safety that have arisen in recent years and how NII's style of regulation has had to adapt to ensure that safety is maintained and improved. NII's approach has been to: be proactive in its relations with Government and market regulators; adopt new competencies to equip it for the challenges it faces; strive to improve its efficiency and effectiveness; and develop new approaches to regulating changes in licensees' organisations and ways of working. Importantly, NII seeks to anticipate change rather than react to it. (author)

Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress

International Nuclear Information System (INIS)

Bryantsev, A.L.; Chechenova, M.B.; Shelden, E.A.

2007-01-01

During stress, the mammalian small heat shock protein Hsp27 enters cell nuclei. The present study examines the requirements for entry of Hsp27 into nuclei of normal rat kidney (NRK) renal epithelial cells, and for its interactions with specific nuclear structures. We find that phosphorylation of Hsp27 is necessary for the efficient entry into nuclei during heat shock but not sufficient for efficient nuclear entry under control conditions. We further report that Hsp27 is recruited to an RNAse sensitive fraction of SC35 positive nuclear speckles, but not other intranuclear structures, in response to heat shock. Intriguingly, Hsp27 phosphorylation, in the absence of stress, is sufficient for recruitment to speckles found in post-anaphase stage mitotic cells. Additionally, pseudophosphorylated Hsp27 fused to a nuclear localization peptide (NLS) is recruited to nuclear speckles in unstressed interphase cells, but wildtype and nonphosphorylatable Hsp27 NLS fusion proteins are not. The expression of NLS-Hsp27 mutants does not enhance colony forming abilities of cells subjected to severe heat shock, but does regulate nuclear speckle morphology. These data demonstrate that phosphorylation, but not stress, mediates Hsp27 recruitment to an RNAse soluble fraction of nuclear speckles and support a site-specific role for Hsp27 within the nucleus

Rules and Regulations on the 27th. Article for Nuclear Aspects

International Nuclear Information System (INIS)

1985-01-01

This law constitutes the Regulations of the Article 27 of the Constitution on nuclear matters, which in turn regulates the exploration, exploitation and benefits of radioactive minerals, as well as the use of nuclear fuels, the use of nuclear energy, research on nuclear techniques and sciences, nuclear industry and all matters related to it. All dispositions of this law are public and to be observed and complied with all throughout Mexico, and state that in this Country, the use of nuclear energy may only have pacific purposes. Likewise, it states all regulations for exploration, exploitation and benefits to be derived from radioactive materials, at the same time comprising the compliance with all facets of the cycle of fuel comprised from its refining to the manufacture or combustible elements. This law also comprises aspects of nuclear, radiologic and physic safety, as well as the safeguards appointed by the National Commission on Nuclear Safety and the compliance with this functions. The research aspect falls on the ININ. This law is constituted by 52 Articles and 6 Transitories

The regulations concerning the uses of nuclear fuel materials

International Nuclear Information System (INIS)

1978-01-01

The Regulations are established on the basis of ''The law for the regulations of nuclear source materials, nuclear fuel materials and reactors'' and the ''Provisions concerning the usage of nuclear fuel materials'' in the Enforcement Ordinance of the Law, to enforce such provisions. Terms are explained, such as exposure radiation dose, cumulative dose, control area, surrounding inspection area, persons engaging in works, area for incoming and outgoing of materials, batch, real stocks, effective value and main measuring points. In the applications for the permission to use nuclear fuel materials, the expected period and quantity of usage of each kind of such materials and the other party and the method of selling, lending and returning spent fuel or the process of disposal of such fuel must be written. Explanations concerning the technical ability required for the usage of nuclear fuel materials shall be attached to the applications. Applications shall be filed for the inspection of facilities for use, in which the name and the address of the applicant, the name and the address of the factory or the establishment, the range of the facilities for use, the maximum quantity of nuclear fuel materials to be used or stocked, and the date, the place and the kind of the expected inspection are written. Prescriptions cover the records to be held, safety regulations, the technical standards for usage, the disposal, transport and storage of nuclear fuel materials and the reports to be filed. (Okada, K.)

The Nuclear Installations (Excepted Matter) Regulations 1978 (Statutory Instrument No. 1779, 4 December 1978)

International Nuclear Information System (INIS)

1979-01-01

These Regulations prescribe, for the purposes of the definition of 'excepted matter' in the Nuclear Installations Act 1965, certain specified quantities and forms of nuclear matter, and supersede the Nuclear Installations (excepted Matter) Regulations 1965. They bring the definition of excepted matter in those Regulations into line with the decisions of 27 October 1977 of the OECD Nuclear Energy Agency's Steering Committee excluding certain kinds and quantities of nuclear substances from the scope of the Paris Convention on Third Party Liability in the Field of Nuclear Energy. Compared with the 1965 Regulations, the principal changes in relation to consignments are that activity limits and packing requirements now take account of the most recent IAEA Regulations. (NEA) [fr

Lifetime Management in Non-US-Technology Nuclear Power Plants using US Regulations

International Nuclear Information System (INIS)

Cornelius Steenkamp, J.; Encabo Espartero, J.; Garcia Iglesias, R.

2013-01-01

In July 2009 the Spanish Nuclear Regulator (CSN) issued a Safety Instruction (IS-22) for the development of Lifetime Management in the Nuclear Power Plants within Spain. The context of this Safety Instruction is based on the American Regulations 10CFR54, NUREG1800/1801 and the technical guide NEI95-10. All these regulations are aimed at US-Technology Nuclear Power Plants. Lifetime Management of Nuclear Power Plants with a plant design different from US technologies can most certainly be developed with the mentioned US regulations. The successful development of Lifetime Management in these cases depends on the adaptation of the different requirements of the regulations. Challenges resulting from the adaptation process can be resolved by taking into consideration the plant design of the plant in question.

The nuclear review

International Nuclear Information System (INIS)

Robinson, C.

1995-01-01

Evidence in favour of privatisation which was submitted to the UK government's review of the nuclear industry is summarised. Only if capital markets judge proposals for new nuclear stations and they operate within competitive markets, can their economic and commercial viability be determined. The problem of state ownership is that politicians' time horizons are too short for an industry that must take a long view, unless standards are set by competitors, costs are likely to rise. Magnox stations, however, should remain in public ownership though to gain efficiency their operation should be contracted out. The rest of Nuclear Electric and Scottish Nuclear should be privatised as generation companies but should not be tied to nuclear generation. Current protective arrangements should be removed as soon as possible. Among the benefits expected from the entry of two formidable new companies into the privatised electricity are efficiency gains, price reductions, a stimulus to entrepeneurship and innovation, and more straightforward regulation. (UK)

The Brussels I Regulation and Liability for Nuclear Damage

International Nuclear Information System (INIS)

Handrlica, J.

2010-01-01

Prior to 2004, the map of the European Union seemed to be basically identical to the map of the contracting parties to the Paris Convention on Third Party Liability in the Field of Nuclear Energy of 1960 ('the Paris Convention'). The 2004 and 2007 enlargements were mainly composed of the contracting parties to the Vienna Convention on Civil Liability for Nuclear Damage of 1963 ('the Vienna Convention'). In various discussions, the term 'nuclear liability patchwork' is used to describe this existing situation. One of the problems arising from this 'patchwork' is that, while a uniform legal framework was established for matters of jurisdiction and the enforcement of decisions under the authority given to the European Union ('EU') by the Council Regulation on jurisdiction and the recognition and enforcement of judgements in civil and commercial matters ('Brussels Regulation'), this overall framework does not apply to particular matters governed by the special conventions to which member states may be contracting parties, see Article 71 of the Brussels Regulation. This paper aims to outline the 'patchwork' of these rules that are applicable to nuclear third party liability cases in the EU and to point out the main consequences arising from this legal framework difficult to comprehend.5 Its scope, however, is limited to the legal issues arising from a nuclear incident occurring in a nuclear installation situated within the territory of the European Union

Critical Reflections on Conservatism in Nuclear Safety Regulation

International Nuclear Information System (INIS)

Choi, Young Sung; Choi, Kwang Sik

2007-01-01

A recent report published by the Committee on Nuclear Regulatory Activities (CNRA) of the OECD Nuclear Energy Agency (NEA) says that a fundamental principle for safety regulators is the practice of conservative decision making. Nuclear regulators frequently face challenging issues surrounded by uncertainties or lack of data and information. No matter what efforts will be made to collect the available information and to assess the issues, nobody can clear all the uncertainties and make absolutely certain decision. More often than not, the regulators have to make a decision in light of continuing uncertainties and limited information. It is at this point that the principle of conservatism should play a role. However the principle comes in many diverse forms such as default conservatism, precautionary principle, defense in depth and realistic conservatism. These different forms of conservatism have different roles and meanings that will take a decision maker to drastically different results. This paper reviews different forms of conservatism in critical way, presents analytical framework for decision making under uncertainty and suggests future research works needed

SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A.

Science.gov (United States)

Luo, Xinlong; Yang, Wei; Gao, Guangxia

2018-07-01

Human immunodeficiency virus type 1 (HIV-1) can infect nondividing cells via passing through the nuclear pore complex. The nuclear membrane-imbedded protein SUN2 was recently reported to be involved in the nuclear import of HIV-1. Whether SUN1, which shares many functional similarities with SUN2, is involved in this process remained to be explored. Here we report that overexpression of SUN1 specifically inhibited infection by HIV-1 but not that by simian immunodeficiency virus (SIV) or murine leukemia virus (MLV). Overexpression of SUN1 did not affect reverse transcription but led to reduced accumulation of the 2-long-terminal-repeat (2-LTR) circular DNA and integrated viral DNA, suggesting a block in the process of nuclear import. HIV-1 CA was mapped as a determinant for viral sensitivity to SUN1. Treatment of SUN1-expressing cells with cyclosporine (CsA) significantly reduced the sensitivity of the virus to SUN1, and an HIV-1 mutant containing CA-G89A, which does not interact with cyclophilin A (CypA), was resistant to SUN1 overexpression. Downregulation of endogenous SUN1 inhibited the nuclear entry of the wild-type virus but not that of the G89A mutant. These results indicate that SUN1 participates in the HIV-1 nuclear entry process in a manner dependent on the interaction of CA with CypA. IMPORTANCE HIV-1 infects both dividing and nondividing cells. The viral preintegration complex (PIC) can enter the nucleus through the nuclear pore complex. It has been well known that the viral protein CA plays an important role in determining the pathways by which the PIC enters the nucleus. In addition, the interaction between CA and the cellular protein CypA has been reported to be important in the selection of nuclear entry pathways, though the underlying mechanisms are not very clear. Here we show that both SUN1 overexpression and downregulation inhibited HIV-1 nuclear entry. CA played an important role in determining the sensitivity of the virus to SUN1: the regulatory

Merits and difficulties in adopting codes, standards and nuclear regulations

International Nuclear Information System (INIS)

El-Saiedi, A.F.; Morsy, S.; Mariy, A.

1978-01-01

Developing countries planning for introducing nuclear power plants as a source of energy have to develop or adopt sound regulatory practices. These are necessary to help governmental authorities to assess the safety of nuclear power plants and to perform inspections needed to confirm the established safe and sound limits. The first requirement is to form an independent regulatory body capable of setting up and enforcing proper safety regulations. The formation of this body is governed by several considerations related to local conditions in the developing countries, which may not always be favourable. It is quite impractical for countries with limited experience in the nuclear power field to develop their own codes, standards and regulations required for the nuclear regulatory body to perform its tasks. A practical way is to adopt codes, standards and regulations of a well-developed country. This has merits as well as drawbacks. The latter are related to problems of personnel, software, equipment and facilities. The difficulties involved in forming a nuclear regulatory body, and the merits and difficulties in adopting foreign codes, standards and regulations required for such body to perform its tasks, are discussed in this paper. Discussions are applicable to many developing countries and particular emphasis is given to the conditions and practices in Egypt. (author)

Nuclear safety regulation in the People's Republic of China

International Nuclear Information System (INIS)

Shi Guangchang

1987-01-01

The present report gives a general view of how the problem of nuclear safety is dealt with in China, with particular reference to the nuclear power plants. The most relevant nuclear legal regulations and procedures are reported. Organization of the National Nuclear Safety Administration (NNSA) of China and its working activities are presented. The report gives also the principle and practice with regard to licensing process and regulatory inspection of nuclear power plant in China. (author)

Proteolysis of virulence regulator ToxR is associated with entry of Vibrio cholerae into a dormant state.

Directory of Open Access Journals (Sweden)

Salvador Almagro-Moreno

2015-04-01

Full Text Available Vibrio cholerae O1 is a natural inhabitant of aquatic environments and causes the diarrheal disease, cholera. Two of its primary virulence regulators, TcpP and ToxR, are localized in the inner membrane. TcpP is encoded on the Vibrio Pathogenicity Island (VPI, a horizontally acquired mobile genetic element, and functions primarily in virulence gene regulation. TcpP has been shown to undergo regulated intramembrane proteolysis (RIP in response to environmental conditions that are unfavorable for virulence gene expression. ToxR is encoded in the ancestral genome and is present in non-pathogenic strains of V. cholerae, indicating it has roles outside of the human host. In this study, we show that ToxR undergoes RIP in V. cholerae in response to nutrient limitation at alkaline pH, a condition that occurs during the stationary phase of growth. This process involves the site-2 protease RseP (YaeL, and is dependent upon the RpoE-mediated periplasmic stress response, as deletion mutants for the genes encoding these two proteins cannot proteolyze ToxR under nutrient limitation at alkaline pH. We determined that the loss of ToxR, genetically or by proteolysis, is associated with entry of V. cholerae into a dormant state in which the bacterium is normally found in the aquatic environment called viable but nonculturable (VBNC. Strains that can proteolyze ToxR, or do not encode it, lose culturability, experience a change in morphology associated with cells in VBNC, yet remain viable under nutrient limitation at alkaline pH. On the other hand, mutant strains that cannot proteolyze ToxR remain culturable and maintain the morphology of cells in an active state of growth. Overall, our findings provide a link between the proteolysis of a virulence regulator and the entry of a pathogen into an environmentally persistent state.

RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary.

Directory of Open Access Journals (Sweden)

Anne-Amandine Chassot

Full Text Available Differentiation of germ cells into male gonocytes or female oocytes is a central event in sexual reproduction. Proliferation and differentiation of fetal germ cells depend on the sex of the embryo. In male mouse embryos, germ cell proliferation is regulated by the RNA helicase Mouse Vasa homolog gene and factors synthesized by the somatic Sertoli cells promote gonocyte differentiation. In the female, ovarian differentiation requires activation of the WNT/β-catenin signaling pathway in the somatic cells by the secreted protein RSPO1. Using mouse models, we now show that Rspo1 also activates the WNT/β-catenin signaling pathway in germ cells. In XX Rspo1(-/- gonads, germ cell proliferation, expression of the early meiotic marker Stra8, and entry into meiosis are all impaired. In these gonads, impaired entry into meiosis and germ cell sex reversal occur prior to detectable Sertoli cell differentiation, suggesting that β-catenin signaling acts within the germ cells to promote oogonial differentiation and entry into meiosis. Our results demonstrate that RSPO1/β-catenin signaling is involved in meiosis in fetal germ cells and contributes to the cellular decision of germ cells to differentiate into oocyte or sperm.

The law for the regulations of nuclear source materials, nuclear fuel materials and reactors

International Nuclear Information System (INIS)

1979-01-01

The law aims to perform regulations on enterprises of refining, processing and reprocessing of nuclear source and fuel materials and on establishment and operation of reactors to realize the peaceful and deliberate utilization of atomic energy according to the principle of the atomic energy basic law. Regulations of use of internationally regulated substances are also envisaged to observe international agreements. Basic concepts and terms are defined, such as: atomic energy; nuclear fuel material; nuclear source material; reactor; refining; processing; reprocessing and internationally regulated substance. Any person besides the Power Reactor and Nuclear Fuel Material Developing Corporation who undertakes refining shall be designated by the Prime Minister and the Minister of International Trade and Industry. An application shall be filed to the ministers concerned, listing name and address of the person, name and location of the refining works, equipment and method of refining, etc. The permission of the Prime Minister is necessary for any person who engages in processing. An application shall be filed to the Prime Minister, listing name and address of the person, name and location of the processing works and equipment and method of processing, etc. Permission of the Prime Minister, the Minister of International Trade and Industry or the Minister of Transport is necessary for any person who sets up reactors. An application shall be filed to the minister concerned, listing name and address of the person, purpose of operation, style, thermal output of reactor and number of units, etc. (Okada, K.)

Small Nuclear Technology and Market Entry

International Nuclear Information System (INIS)

Stewart, J S; Schock, R N; Brown, N W; Smith, C F

2002-01-01

An overview of energy-system projections into the new century leads to the conclusion that nuclear power will play a significant role. How significant a role will be determined by the marketplace. Within the range of nuclear-power technologies available, small nuclear-power plants of innovative design appear to fit the needs of a number of developing nations and states. Under similar financing options used by the airline industry and others, the capital requirement barrier that puts the nuclear industry at a disadvantage in deregulated markets could be reduced. These plants have the potential advantage of modularity, are proliferation-resistant, incorporate passive safety features, minimize waste, and could be cost-competitive with fossil-fuel plants

The UAE. Lessons learned from a new nuclear regulator

International Nuclear Information System (INIS)

Kraev, Kamen

2015-01-01

The United Arab Emirates (UAE) is building four South Korean APR-1400 reactors at the Barakah nuclear site. The first is scheduled to enter into commercial operation in 2017. Christer Viktorsson, Director General of the United Arabic Emirate's(UAE) Federal Office for Nuclear Regulation, talks to NucNet about the challenges of establishing a nuclear regulatory body from scratch in a country where nuclear stations have never been built before.

The UAE. Lessons learned from a new nuclear regulator

Energy Technology Data Exchange (ETDEWEB)

Kraev, Kamen [NucNet, Brussels (Belgium)

2015-12-15

The United Arab Emirates (UAE) is building four South Korean APR-1400 reactors at the Barakah nuclear site. The first is scheduled to enter into commercial operation in 2017. Christer Viktorsson, Director General of the United Arabic Emirate's(UAE) Federal Office for Nuclear Regulation, talks to NucNet about the challenges of establishing a nuclear regulatory body from scratch in a country where nuclear stations have never been built before.

Review of Nuclear Regulation using Principal-Agent Model

Energy Technology Data Exchange (ETDEWEB)

Choi, Kwang Sik; Lee, Young Eal; Ryu, Yong Ho [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2010-05-15

Regulation is performed by the government on behalf of the public to accomplish a societal goal. However, the public is not necessarily confident that regulatory authority does well enough for the benefit of the public. That is partly because they have less information, competence and resources for monitoring regulatory activities. However, it is a problem that cannot be solved easily only by efforts of the personnel involved. In nuclear industry and regulation, there is increasing concerns of the local community on the decision making related to the safety matters on nuclear facilities. Resident people on NPP sites realize that radiation risk caused by the NPPs is their first concern, whereas the general public as a whole is less concerned with the radiation risk or nuclear safety. Regulatory organizations have less motivation to do their best because they pursue their private or group interests. In this paper, the above mentioned issue has been reviewed in terms of principal agent problem(PAP) theory and also the PAP model for Korean nuclear regulatory system has been developed

Review of Nuclear Regulation using Principal-Agent Model

International Nuclear Information System (INIS)

Choi, Kwang Sik; Lee, Young Eal; Ryu, Yong Ho

2010-01-01

Regulation is performed by the government on behalf of the public to accomplish a societal goal. However, the public is not necessarily confident that regulatory authority does well enough for the benefit of the public. That is partly because they have less information, competence and resources for monitoring regulatory activities. However, it is a problem that cannot be solved easily only by efforts of the personnel involved. In nuclear industry and regulation, there is increasing concerns of the local community on the decision making related to the safety matters on nuclear facilities. Resident people on NPP sites realize that radiation risk caused by the NPPs is their first concern, whereas the general public as a whole is less concerned with the radiation risk or nuclear safety. Regulatory organizations have less motivation to do their best because they pursue their private or group interests. In this paper, the above mentioned issue has been reviewed in terms of principal agent problem(PAP) theory and also the PAP model for Korean nuclear regulatory system has been developed

Safety regulation KTA 3901: Communication systems for nuclear power plants

International Nuclear Information System (INIS)

1981-01-01

The regulation applies to communication systems in stationary nuclear power plants with at least one power plant unit, i.e. alarm systems, staff locator systems, communicators, and systems for external communication. The regulation determines the type and extent of staff communication systems as well as the demands to be made on layout, installation, operating systems, and testing of communication systems for nuclear power plants. (orig./HP) [de

Transparency in Nuclear Regulation: Trends and Future Prospects

International Nuclear Information System (INIS)

Choi, Kwang Sik; Choi, Young Sung; Kim, Seong Ho

2007-01-01

Recently, improving transparency (or openness) has been one of important issues related to nuclear safety worldwide. As for the transparency in nuclear regulatory activities in Korea, openness has been declared as one of five principles of the nuclear regulation in the 'nuclear safety policy statement' announced in 1994. Transparency has been discussed and emphasized in various international meetings such as the Convention on Nuclear Safety, OECD/NEA meetings, etc. For example, Working Group on Public Communication of nuclear regulatory organizations (WGPC) of the OECD/NEA/CNRA held a workshop on 'the transparency of nuclear regulatory activities' in May 2007 in Tokyo, Japan. In this paper, definition of transparency and its international trends ranging from a general administration to nuclear safety activities are discussed based on the results of meetings and workshops held so far. Measures for improvement associated with transparency are also proposed

Nuclear power for energy production and hazardous waste regulations in India

International Nuclear Information System (INIS)

Sharma, Prabhakar; Goel, Gaurav

2010-01-01

Before installing any nuclear power- generation plants in India, it is important to implement stringent regulations for the health and safety of the people and for protection of the environment, soil and water from the nuclear and hazardous waste produced in the power plants. Although some initiatives have been taken for radioactive waste disposal in India, the current hazardous and nuclear waste storage/disposal regulations are still too soft and are not being implemented properly in the country

The nuclear import of ribosomal proteins is regulated by mTOR

Science.gov (United States)

Kazyken, Dubek; Kaz, Yelimbek; Kiyan, Vladimir; Zhylkibayev, Assylbek A.; Chen, Chien-Hung; Agarwal, Nitin K.; Sarbassov, Dos D.

2014-01-01

Mechanistic target of rapamycin (mTOR) is a central component of the essential signaling pathway that regulates cell growth and proliferation by controlling anabolic processes in cells. mTOR exists in two distinct mTOR complexes known as mTORC1 and mTORC2 that reside mostly in cytoplasm. In our study, the biochemical characterization of mTOR led to discovery of its novel localization on nuclear envelope where it associates with a critical regulator of nuclear import Ran Binding Protein 2 (RanBP2). We show that association of mTOR with RanBP2 is dependent on the mTOR kinase activity that regulates the nuclear import of ribosomal proteins. The mTOR kinase inhibitors within thirty minutes caused a substantial decrease of ribosomal proteins in the nuclear but not cytoplasmic fraction. Detection of a nuclear accumulation of the GFP-tagged ribosomal protein rpL7a also indicated its dependence on the mTOR kinase activity. The nuclear abundance of ribosomal proteins was not affected by inhibition of mTOR Complex 1 (mTORC1) by rapamycin or deficiency of mTORC2, suggesting a distinctive role of the nuclear envelope mTOR complex in the nuclear import. Thus, we identified that mTOR in association with RanBP2 mediates the active nuclear import of ribosomal proteins. PMID:25294810

Nuclear regulation of South African mines: An industry perspective

International Nuclear Information System (INIS)

Wymer, D.G.

2001-01-01

South African mines have become subject to a rigid and prescriptive system of nuclear regulation that has its roots in the past when South Africa embarked upon a period of nuclear development spanning the full nuclear fuel cycle, and in which the South African gold mining industry once played a major part in the supply of uranium as a low grade by-product. Radiation hazards in the mines are generally very moderate, even in the few gold mines associated with uranium by-product, and to not warrant the type of regulatory attention normally applied to nuclear installations, or even to uranium mines. The continued imposition of strict nuclear regulatory requirements has caused severe financial hardship and threatens the survival of certain mining operations, while seemingly having little or no health benefits to workers or the public. With the development of modern, comprehensive mine health and safety legislation, a more appropriate, effective, and far less costly vehicle for controlling radiation hazards in mines now exists, utilizing the resources of the Mine Health and Safety Inspectorate. This approach is now being proposed, in the drafting of new legislation, as constituting a better alternative to the nuclear regulation of mines. (author)

Regulations and financing for decommissioning of nuclear facilities

International Nuclear Information System (INIS)

Kumakura, Osamu

1981-01-01

The purpose of this report is to survey the French legislation concerning the decommissioning of nuclear facilities and the method of financing for it. There is no clause in French regulations, which states any specific criterion or licensing procedure for the proper decommissioning. The legal problems in this domain are treated within the general regulation system on atomic energy. The decommissioning of nuclear facilities is carried out in accordance with the licensing procedure for constructing nuclear facilities or the permission procedure for operating them, according to the ''Decree on nuclear installations, 1963''. The works for the final shut-down and decommissioning are regarded as the modification to the safety report or the general operation instructions, and new permit is required. In the case that the radioactivity of substances after decommissioning is above the criteria of the Decree, 1963, the new license is required. In the case of below the criteria, the facilities are governed by the ''Act on installations classified for environmental protection, 1976''. The ''Decree on general radiation protection, 1966'', the ''Decree on radiation protection of workers in nuclear installations, 1975'', the ''Ministerial order on transport of dangerous materials, 1945'', and two ministerial orders on radioactive effluent discharge, 1974, are applied to the decommissioning works. (Kako, I.)

The regulations concerning the uses of nuclear source materials

International Nuclear Information System (INIS)

1981-01-01

This rule is established under the provisions of the law concerning the regulation of nuclear raw materials, nuclear fuel materials and nuclear reactors and the ordinance for the execution of this law, and to enforce them. Basic terms are defined, such as exposure radiation dose, cumulative dose, control area, surrounding monitoring area, worker and radioactive waste. Nuclear raw materials shall be used at the facilities for using them, and control areas and surrounding monitoring areas shall be set up. Cumulative dose and exposure radiation dose of workers shall not exceed the permissible quantities defined by the General Director of the Science and Technology Agency. Records shall be made in each works or enterprise on the accept, delivery and stock of each kind of nuclear raw materials, radiation control and the accidents in the facilities of using nuclear raw materials, and kept for specified periods, respectively. The users of nuclear raw materials shall present reports in each works or enterprise on the stock of these materials on July 30 and December 31, every year. They shall submit reports immediately to the Director General on the particular accidents concerning nuclear raw materials and their facilities and on the circumstances and the measures taken against such accidents within ten days. These reports shall be presented on internationally regulated raw materials too. (Okada, K.)

Safety experts complete second IAEA regulatory review of UK nuclear regulator

International Nuclear Information System (INIS)

2009-01-01

Full text: Nuclear safety experts today concluded a 10-day mission to peer-review the UK Nuclear Regulator: Health and Safety Executive (HSE), Nuclear Directorate (ND). At the request of the UK Government, the International Atomic Energy Agency assembled a team of ten high-level regulatory experts from eight nations to conduct the Integrated Regulatory Review Service (IRRS) mission. The mission was the second of three planned IRRS missions for the United Kingdom. The first was held in March 2006 to begin a process to assess the nation's readiness to regulate and license new reactor designs, considered as a result of the Energy Policy review initiated by the British Prime Minister and the Secretary of State for Trade and Industry (DTI) in 2005. The IRRS team leader Mr. William Borchardt, Executive Director of Operations from the US Nuclear Regulatory Commission, stated, ''The IAEA IRRS serves an important role in both benchmarking against its safety standards and in promoting dialogue between nuclear safety regulators from around the world.'' During the 2nd mission the IRRS the team reviewed HSE/ND progress since the first IRRS mission and recent regulatory developments, the regulation of operating power plants and fuel cycle facilities, the inspection and enforcement programme for nuclear power plants and fuel cycle facilities, and the emergency preparedness and response programme. The IAEA found that HSE/ND has made significant progress toward improving its effectiveness in regulating existing nuclear power plants and in preparing to license new nuclear reactors designs. Many of the findings identified in the 2006 report had been fully addressed and therefore could be considered closed, the others are being addressed in accordance with a comprehensive action plan. IRRS team members visited the Heysham 1 Nuclear Power Plant near Lancaster, the Sellafield site at Cumbria and the Strategic Control Centre at Hutton, and they met senior managers from HSE and a UK

The Relationship Between Nuclear Regulators and Their Stakeholders

International Nuclear Information System (INIS)

Burns, Stephen G.

2017-01-01

Mr Burns, Chairman of the United States Nuclear Regulatory Commission, delivered a keynote speech. He recognised there is a global movement towards broadening information flow and participation. He displayed the so-called Arnstein 'ladder' that can be applied to assess the degree of public involvement and influence achieved in any state or private decision making. The lower rungs depict non-participation and the middle rungs focus on education and information as well as consultation. Mr Burns suggested that the higher level of partnership was of most interest to the workshop. In his experience, partnership between stakeholders and regulatory organisations, as well as openness and transparency, are today seen as traits of a good regulator, and are increasingly set out as goals in regulatory strategic plans throughout the world. Mr Burns highlighted a broad definition of 'stakeholder' as 'one who is involved in or affected by a course of action'. Nuclear stakeholders thus include those who live near or work in nuclear facilities; own or run the facilities; govern at the national, regional or local level; manufacture the components or the fuel; regulate the output or use of the facility; benefit from the use of radiological material and nuclear installations; and those who might be adversely affected in any way by materials or facilities. Stakeholders also include the media who convey information to others, and the non-governmental organisations that represent the views of many individuals. Mr Burns focused on the concept of trust as enabling public confidence in technical calculations and risk management. He suggested that listening carefully to stakeholders is an important element of trust-building. He closed by affirming that regulators can maintain their independence while nonetheless considering others' opinions. Mr Burns emphasised that at the end of the day, the regulator holds sole responsibility for achieving its own regulatory objectives and consistent, well

The regulations concerning the uses of nuclear fuel materials

International Nuclear Information System (INIS)

1979-01-01

The regulations are defined under the law for the regulations of nuclear source materials, nuclear fuel materials and reactors and provisions concerning the uses of nuclear fuel materials in the order for execution of the law. Basic concepts and terms are explained, such as: exposure dose; accumulative dose; controlled area; inspected surrounding area and employee. The application for permission shall state the expected period and amount of the uses for each kind of nuclear fuel materials. Persons to whom spent fuels shall be sold, lent or returned and the method of disposal of such fuels shall be also indicated. Records shall be made and kept for particular periods for each works and enterprise on inspection of facilities, control of dose, maintenance and accident of facilities in use. The application for permission of the safeguard regulations shall report rules for each works and enterprise on the faculty and organization of controllers of facilities in use, safeguard education of employees, operation of apparatus which needs special control for prevention of disaster, establishment of controlled and inspected surrounding areas, entrance limitation, inspection of exposure dose, etc. Technical standards of the uses of nuclear fuel materials, disposal and transportation in the works and the enterprise and storage are stipulated in detail. Reports on exposure dose of employees and other specified matters shall be submitted every year to the Director General of Science and Technology Agency according to the forms attached. (Okada, K.)

Recent achievements in regulating nuclear power activities in taiwan

International Nuclear Information System (INIS)

Ouyang, M.S.

2006-01-01

Full text: The energy resources in Taiwan are very scarce with more than 98% of the fuel sources imported from foreign countries. The nuclear power became essential because of its stability and economy in price. There are six operating nuclear power units in Taiwan, and two more advanced boiling water reactor units under construction. As the country's nuclear power still plays an important role, the Atomic Energy Council (AEC) devotes its great efforts working on reactor safety regulation, radiation protection, nuclear security, nuclear emergency preparedness, nuclear waste management and environmental monitoring. Recent achievements of AEC on the above mentioned topics will be covered in this presentation

Regulation on the transport of nuclear fuel materials by vehicles

International Nuclear Information System (INIS)

1984-01-01

The regulations applying to the transport of nuclear fuel materials by vehicles, mentioned in the law for the regulations of nuclear source materials, nuclear fuel materials and reactors. The transport is for outside of the factories and the site of enterprises by such modes of transport as rail, trucks, etc. Covered are the following: definitions of terms, places of fuel materials handling, loading methods, limitations on mix loading with other cargo, radiation dose rates concerning the containers and the vehicles, transport indexes, signs and indications, limitations on train linkage during transport by rail, security guards, transport of empty containers, etc. together with ordinary rail cargo and so on. (Mori, K.)

Regulations on nuclear materials control of the People's Republic of China

International Nuclear Information System (INIS)

1996-01-01

The present 'Regulations on Nuclear Materials Control of the People's Republic of China' were promulgated by the State Council on June 15, 1987, which are enacted to ensure safe and lawful use of nuclear materials, to prevent theft, sabotage, lose, unlawful diversion and unlawful use, to protect the security of the State and the Public and to facilitate the development of nuclear undertakings. The nuclear materials controlled are: 1. Uranium-235 (materials and products); 2. Uranium-233 (material and products); 3. Plutonium-239 (materials and products); 4. tritium (materials and products); 5. lithium-6 (materials and products); 6. Other nuclear materials requiring control. The present regulations are not applicable to the control of uranium ore and its primary products. The control measures for nuclear products transferred to the armed forces shall be laid down by the national defence department

A new Brazilian regulation for the security of nuclear material and nuclear facilities

Energy Technology Data Exchange (ETDEWEB)

Tavares, Renato L.A.; Filho, Josélio S.M.; Torres, Luiz F.B.; Lima, Alexandre R., E-mail: renato.tavares@cnen.gov.br, E-mail: joselio@cnen.gov.br, E-mail: ltorres@cnen.gov.br, E-mail: alexandre.lima@cnen.gov.br [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil). Diretoria de Radioproteção e Segurança Nuclear; Lima, Fabiano P.C., E-mail: fabianopetruceli@outlook.com [Presidência da República, Brasilia, DF (Brazil). Gabinete de Segurança Institucional

2017-07-01

The present paper aims to outline the challenges related to the elaboration and concepts involved in a regulatory transition from a purely prescriptive approach to a combined approach that mixes performance-based concepts and evaluation metrics based on statistical data of equipment and personnel. This methodology might represent an improvement compared to a purely prescriptive approach, in which the regulatory authority defines the measures to be taken by operators of nuclear facilities to prevent theft, sabotage events, and mitigate their consequences. The prescriptive approach, despite having the advantages of clarity in the definition of requirements, simplicity in regulatory terms (inspections to verify compliance), and homogeneity in relation to various facilities, does not allow a clear and effective performance measurement, may provide insufficient or excessive security measures (with excessive expenditure of material and human resources), and the possibility of providing a false sense of security. It is known that, in many countries, the state-sponsored nuclear security regime mixes elements of the two mentioned approaches, prescriptive and based on performance, which is not Brazilian practice nowadays. Such methodological developments happened globally due to the increase of threat level for nuclear facilities and materials. The currently regulation in force is CNEN-NE 2.01, which provides a set of measures intended to implement Physical Protection Systems in Nuclear, Radiological Facilities as well as Transport Operations, and all documents related to security of such issues. The new regulation, named CNEN-NN 2.01, will focus only on Nuclear Material and Facilities (two other regulations specific for Security of Radioactive Sources and Transport Operations are under elaboration process). CNEN NN 2.01 is intended to provide further adherence to new international recommendations, e.g, IAEA INFCIRC 225 Rev.5 (NSS 13), which is currently regarded as the �

A new Brazilian regulation for the security of nuclear material and nuclear facilities

International Nuclear Information System (INIS)

Tavares, Renato L.A.; Filho, Josélio S.M.; Torres, Luiz F.B.; Lima, Alexandre R.; Lima, Fabiano P.C.

2017-01-01

The present paper aims to outline the challenges related to the elaboration and concepts involved in a regulatory transition from a purely prescriptive approach to a combined approach that mixes performance-based concepts and evaluation metrics based on statistical data of equipment and personnel. This methodology might represent an improvement compared to a purely prescriptive approach, in which the regulatory authority defines the measures to be taken by operators of nuclear facilities to prevent theft, sabotage events, and mitigate their consequences. The prescriptive approach, despite having the advantages of clarity in the definition of requirements, simplicity in regulatory terms (inspections to verify compliance), and homogeneity in relation to various facilities, does not allow a clear and effective performance measurement, may provide insufficient or excessive security measures (with excessive expenditure of material and human resources), and the possibility of providing a false sense of security. It is known that, in many countries, the state-sponsored nuclear security regime mixes elements of the two mentioned approaches, prescriptive and based on performance, which is not Brazilian practice nowadays. Such methodological developments happened globally due to the increase of threat level for nuclear facilities and materials. The currently regulation in force is CNEN-NE 2.01, which provides a set of measures intended to implement Physical Protection Systems in Nuclear, Radiological Facilities as well as Transport Operations, and all documents related to security of such issues. The new regulation, named CNEN-NN 2.01, will focus only on Nuclear Material and Facilities (two other regulations specific for Security of Radioactive Sources and Transport Operations are under elaboration process). CNEN NN 2.01 is intended to provide further adherence to new international recommendations, e.g, IAEA INFCIRC 225 Rev.5 (NSS 13), which is currently regarded as the �

Basic principles for regulating nuclear activities

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-01

The AECB has developed as its mission statement: `To ensure that the use of nuclear energy in Canada does not pose undue risk to health, safety, security and the environment`. This report proposes eleven qualitative principles for regulating nuclear activities whose achievement would satisfy the broad policy enunciated in the statement. They would further provide a basis for the specific regulatory requirements expressed by the AECB in its Regulations and other documents. They would thus represent a connecting link between the policy enunciated in the mission statement and the requirements. The proposed principles are largely concerned with how the allowable risk should be set for members of the public, for industry workers, for society as a whole, and for the environment. In making these recommendations the risks from normal operation of the licensed facility and those from a possible serious accident are considered separately. The distribution of risk between geographic communities and between generations is also addressed in the proposed principles. These are listed in the final section of the report. 23 refs.

Basic principles for regulating nuclear activities

International Nuclear Information System (INIS)

1996-03-01

The AECB has developed as its mission statement: 'To ensure that the use of nuclear energy in Canada does not pose undue risk to health, safety, security and the environment'. This report proposes eleven qualitative principles for regulating nuclear activities whose achievement would satisfy the broad policy enunciated in the statement. They would further provide a basis for the specific regulatory requirements expressed by the AECB in its Regulations and other documents. They would thus represent a connecting link between the policy enunciated in the mission statement and the requirements. The proposed principles are largely concerned with how the allowable risk should be set for members of the public, for industry workers, for society as a whole, and for the environment. In making these recommendations the risks from normal operation of the licensed facility and those from a possible serious accident are considered separately. The distribution of risk between geographic communities and between generations is also addressed in the proposed principles. These are listed in the final section of the report. 23 refs

The improvement of nuclear safety regulation : American, European, Japanese, and South Korean experiences

International Nuclear Information System (INIS)

Cho, Byung Sun

2005-01-01

Key concepts in South Korean nuclear safety regulation are safety and risk. Nuclear regulation in South Korea has required reactor designs and safeguards that reduce the risk of a major accident to less than one in a million reactor-years-a risk supposedly low enough to be acceptable. To data, in South Korean nuclear safety regulation has involved the establishment of many technical standards to enable administration enforcement. In scientific lawsuits in which the legal issue is the validity of specialized technical standards that are used for judge whether a particular nuclear power plant is to be licensed, the concept of uncertainty law is often raised with regard to what extent the examination and judgement by the judicial power affects a discretion made by the administrative office. In other words, the safety standards for nuclear power plants has been adapted as a form of the scientific technical standards widely under the idea of uncertainty law. Thus, the improvement of nuclear safety regulation in South Korea seems to depend on the rational lawmaking and a reasonable, judicial examination of the scientific standards on nuclear safety

Evaluation of training programs and entry-level qualifications for nuclear-power-plant control-room personnel based on the systems approach to training

International Nuclear Information System (INIS)

Haas, P.M.; Selby, D.L.; Hanley, M.J.; Mercer, R.T.

1983-09-01

This report summarizes results of research sponsored by the US Nuclear Regulatory Commission (NRC) Office of Nuclear Regulatory Research to initiate the use of the Systems Approach to Training in the evaluation of training programs and entry level qualifications for nuclear power plant (NPP) personnel. Variables (performance shaping factors) of potential importance to personnel selection and training are identified, and research to more rigorously define an operationally useful taxonomy of those variables is recommended. A high-level model of the Systems Approach to Training for use in the nuclear industry, which could serve as a model for NRC evaluation of industry programs, is presented. The model is consistent with current publically stated NRC policy, with the approach being followed by the Institute for Nuclear Power Operations, and with current training technology. Checklists to be used by NRC evaluators to assess training programs for NPP control-room personnel are proposed which are based on this model

Evaluation of training programs and entry-level qualifications for nuclear-power-plant control-room personnel based on the systems approach to training

Energy Technology Data Exchange (ETDEWEB)

Haas, P M; Selby, D L; Hanley, M J; Mercer, R T

1983-09-01

This report summarizes results of research sponsored by the US Nuclear Regulatory Commission (NRC) Office of Nuclear Regulatory Research to initiate the use of the Systems Approach to Training in the evaluation of training programs and entry level qualifications for nuclear power plant (NPP) personnel. Variables (performance shaping factors) of potential importance to personnel selection and training are identified, and research to more rigorously define an operationally useful taxonomy of those variables is recommended. A high-level model of the Systems Approach to Training for use in the nuclear industry, which could serve as a model for NRC evaluation of industry programs, is presented. The model is consistent with current publically stated NRC policy, with the approach being followed by the Institute for Nuclear Power Operations, and with current training technology. Checklists to be used by NRC evaluators to assess training programs for NPP control-room personnel are proposed which are based on this model.

Safety culture in nuclear installations - The role of the regulator

International Nuclear Information System (INIS)

Karigi, Alice W.

2002-01-01

Safety culture is an amalgamation of values, standards, morals and norms of acceptable behavior by the licensees, Radiation workers and the Regulator. The role played by a Regulator in establishing safety culture in a nuclear installation is that related to Authorization, review, assessment, inspection and enforcement. The regulator is to follow the development of a facility or activity from initial selection of the site through design, construction, commissioning, radioactive waste management through to decommissioning and closure. He is to ensure safety measures are followed through out the operation of the facility by laying down in the license conditions of controlling construction of nuclear installations and ensuring competence of the operators. (author)

Some issues on the Law for the Regulations of Nuclear Source Material, Nuclear Fuel Material and Reactors Amendment after JCO criticality accident

International Nuclear Information System (INIS)

Tanabe, Tomoyuki

2001-01-01

As the Amendment of the Law for the Regulation of Nuclear Material, Nuclear Fuel Material and Reactors on an opportunity of the JCO criticality accident can be almost evaluated at a viewpoint of upgrading on effectiveness of safety regulation, it is thought to remain a large problem to rely on only enforcement of regulation due to amendment of the Law at future accident. In future, it can be also said to be important subjects to further expand a philosophy on the regulation (material regulation) focussed to hazards of nuclear material itself, not only to secure effectiveness on the multi-complementary safety regulation due to the administrative agency and the Nuclear Safety Commission but also to prepare a mechanism reflexible of a new information to the safety regulation, and to prepare a mechanism to assist adequate business execution and so forth of enterprises. (G.K.)

Incentive regulation of investor-owned nuclear power plants by public utility regulators

International Nuclear Information System (INIS)

McKinney, M.D.; Elliot, D.B.

1993-01-01

The US Nuclear Regulatory Commission (NRC) periodically surveys the Federal Energy Regulatory Commission (FERC) and state regulatory commissions that regulate utility owners of nuclear power plants. The NRC is interested in identifying states that have established economic or performance incentive programs applicable to nuclear power plants, including states with new programs, how the programs are being implemented, and in determining the financial impact of the programs on the utilities. The NRC interest stems from the fact that such programs have the potential to adversely affect the safety of nuclear power plants. The information in this report was obtained from interviews conducted with each state regulatory agency that administers an incentive program and each utility that owns at least 10% of an affected nuclear power plant. The agreements, orders, and settlements that form the basis for each incentive program were reviewed as required. The interviews and supporting documentation form the basis for the individual state reports describing the structure and financial impact of each incentive program

Energy Information Data Base: corporate author entries

International Nuclear Information System (INIS)

1978-06-01

The DOE Energy Information Data Base has been created and is maintained by the DOE Technical Information Center. One of the controls for information entered into the base is the standardized name of the corporate entity or the corporate author. The purpose of this list of authorized or standardized corporate entries is to provide a means for the consistent citing of the names of organizations in bibliographic records. It also serves as a guide for users who retrieve information from a bibliographic data base and who want to locate information originating in particular organizations. This authority is a combination of entries established by the Technical Information Center and the International Atomic Energy Agency's International Nuclear Information System (INIS). The format calls, in general, for the name of the organization represented by the literature being cataloged to be cited as follows: the largest element, the place, the smallest element, e.g., Brigham Young Univ., Provo, Utah (USA), Dept. of Chemical Engineering. Code numbers are assigned to each entry to provide manipulation by computer. Cross references are used to reflect name changes and invalid entries

HIV/AIDS testing at ports of entry in China.

Science.gov (United States)

Lai, Dejian; Hwang, Lu-Yu; Beasley, R Palmer

2011-05-01

In 2007 the Chinese government issued regulations requiring HIV/AIDS testing for Chinese citizens returning at ports of entry if they had resided outside China for 1 year or longer. Three years after publication and partial implementation of the regulations, the Chinese government decided to eliminate compulsory HIV/AIDS testing of returning Chinese. We examine the history of China's HIV/AIDS testing regulations on entry-exit populations, showing how China has gradually altered its policy. As of December 2010, the policy of compulsory HIV/AIDS testing of returning Chinese has been abandoned; however, the regulations still compel HIV/AIDS testing for other groups inside China. Our review sheds new light on the dynamics of regulatory changes in the last 3 years. The Chinese experience that we observed may provide useful insights for policymakers in other parts of the world.

The radioactive waste regulation in the new Czech Nuclear Energy Act

International Nuclear Information System (INIS)

Kucerka, M.

1995-01-01

Recently, in the Czech Republic, there is in the phase of development the Act on Peaceful Use of Nuclear Energy and Ionizing Radiation, so called the Nuclear Energy Act. This Act has to replace existing regulations and fulfill some not yet covered fields of that area. The act is developed as so called ''umbrella act'' and has to cover all aspects of the nuclear energy and ionizing radiation use, from uranium mining or isotopes use in medicine, to the power generation in nuclear power plants. It will include among others also provisions on registration and licensing, liability for nuclear damage, decommissioning and radioactive waste management funding, and some other topics, that were missing in the regulations up to today. The paper describes recent state policy in the field of radioactive waste management and the main provisions of proposed Nuclear Energy Act, concerning the radioactive waste management

Compact, self-regulating nuclear power source

International Nuclear Information System (INIS)

Peterson, Otis G.; Kimpland, Robert H.

2008-01-01

An inherently safe nuclear power source has been designed, that is self-stabilizing and requires no moving mechanical components. Unlike conventional designs, the proposed reactor is self-regulating through the inherent properties of uranium hydride, which serves as a combination fuel and moderator. The temperature driven mobility of the hydrogen contained in the hydride will control the nuclear activity. If the core temperature increases over the set point, the hydrogen is driven out of the core, the moderation drops and the power production decreases. If the temperature drops, the hydrogen returns and the process is reversed. Thus the design is inherently fail-safe and requires only minimal human oversight. The compact nature and inherent safety opens the possibility for low-cost mass production and operation of the reactors. This design has the capability to dramatically alter the manner in which nuclear energy is harnessed for commercial use. (author)

Synthesis of the panel information principles for nuclear regulators: the journalist's view

International Nuclear Information System (INIS)

Lippman, T.W.

1994-01-01

The four journalists who participated in the OECD Nuclear Energy Agency seminar were M. Thomas Lippman, United States; Ms. Anna Schytt, Sweden; M. Michel Lemeret, Belgium; and M. Francis Sorin, France. Although the nuclear industry is structured differently in each of these countries, the journalists who have written about it for many years agreed on certain basic points. In order to have the confidence of the public, nuclear regulators must function openly, provide accurate and dispassionate information, have a reservoir of available technical knowledge and be independent of government and politics. Their purpose should be to regulate, rather than to promote the nuclear energy industry. The participants agreed that it is part of the regulators' role to provide information to the public on a regular basis, to forestall misunderstanding and potential panic. But this must be done in a way that does not appear to be promoting the nuclear power industry as such. (author)

Procedural problems in phase-out regulations in nuclear law

International Nuclear Information System (INIS)

Kloepfer, Michael

2012-01-01

The contribution discusses the legal regulations accompanying German nuclear policy during the past twelve years. There were several radical changes in 2002, 2010, and 2011 which reflect the opinions of the then German governments; some of these regulations, according to the author, were not compatible with German constitutional law.

Risk analysis of nuclear safeguards regulations

International Nuclear Information System (INIS)

Al-Ayat, R.A.; Altman, W.D.; Judd, B.R.

1982-06-01

The Aggregated Systems Model (ASM), a probabilisitic risk analysis tool for nuclear safeguards, was applied to determine benefits and costs of proposed amendments to NRC regulations governing nuclear material control and accounting systems. The objective of the amendments was to improve the ability to detect insiders attempting to steal large quantities of special nuclear material (SNM). Insider threats range from likely events with minor consequences to unlikely events with catastrophic consequences. Moreover, establishing safeguards regulations is complicated by uncertainties in threats, safeguards performance, and consequences, and by the subjective judgments and difficult trade-offs between risks and safeguards costs. The ASM systematically incorporates these factors in a comprehensive, analytical framework. The ASM was used to evaluate the effectiveness of current safeguards and to quantify the risk of SNM theft. Various modifications designed to meet the objectives of the proposed amendments to reduce that risk were analyzed. Safeguards effectiveness was judged in terms of the probability of detecting and preventing theft, the expected time to detection, and the expected quantity of SNM diverted in a year. Data were gathered in tours and interviews at NRC-licensed facilities. The assessment at each facility was begun by carefully selecting scenarios representing the range of potential insider threats. A team of analysts and facility managers assigned probabilities for detection and prevention events in each scenario. Using the ASM we computed the measures of system effectiveness and identified cost-effective safeguards modifications that met the objectives of the proposed amendments

ER-E3 regulation. Minimal instrumentation that must operate nuclear medicine in Cuba

International Nuclear Information System (INIS)

2015-01-01

The purpose of this regulation is to define the instrumentation that must exist in any institution conducting the practice of nuclear medicine in Cuba. This regulation emphasizes two aspects: The minimum equipment necessary to operate a nuclear medicine laboratory for use 'in vitro' and the minimum equipment required to operate a Nuclear Medicine use 'in vivo'

31 CFR 363.95 - How may I give, and who can receive, a book-entry savings bond as a gift?

Science.gov (United States)

2010-07-01

... may give a book-entry savings bond as a gift in two ways: (a) An individual may purchase a book-entry..., a book-entry savings bond as a gift? 363.95 Section 363.95 Money and Finance: Treasury Regulations... DEBT REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT Book-Entry Savings Bonds Purchased Through...

Methodological aspects of journaling a dynamic adjusting entry model

Directory of Open Access Journals (Sweden)

Vlasta Kašparovská

2011-01-01

Full Text Available This paper expands the discussion of the importance and function of adjusting entries for loan receivables. Discussion of the cyclical development of adjusting entries, their negative impact on the business cycle and potential solutions has intensified during the financial crisis. These discussions are still ongoing and continue to be relevant to members of the professional public, banking regulators and representatives of international accounting institutions. The objective of this paper is to evaluate a method of journaling dynamic adjusting entries under current accounting law. It also expresses the authors’ opinions on the potential for consistently implementing basic accounting principles in journaling adjusting entries for loan receivables under a dynamic model.

19 CFR 122.26 - Entry and clearance.

Science.gov (United States)

2010-04-01

... AIR COMMERCE REGULATIONS Private Aircraft § 122.26 Entry and clearance. Private aircraft, as defined... information as set forth in § 122.22(c), and grants electronic clearance via electronic mail or telephone...

Connections or conflicts between nuclear regulations and other regulations

International Nuclear Information System (INIS)

Shapar, H.K.

1976-01-01

The potential for conflicts between nuclear and other regulations stems in large part from overlapping jurisdictional lines which reflect not only the basic governmental structure but the political realities as well. A completely logical pattern - with a clear differentiation of responsibilities assigned to the various departments and agencies involved - is assuredly a worthy goal, but one not often, if ever, achieved. Fortunately, innovative means for obviating or mitigating the conflicts can be and have been found. (Auth) [fr

Design of an optimal automatic regulator for regulating the power levels of a nuclear reactor in a wind power range

International Nuclear Information System (INIS)

Noori Khajavi, M.; Menhaj, M.B.; Ghofrani, M.B.

2000-01-01

Nuclear power reactors are, in nature nonlinear and time varying. These characteristics must be considered, if large power variations occur in their working regime. In this paper a robust optimal self-tuning regulator for regulating the power of a nuclear reactor has been designed and simulated. The proposed controller is capable of regulating power levels in a wide power range (10% to 100% power levels). The controller achieves a fast and good transient response. The simulation results show that the proposed controller outperforms the fixed optimal control recently cited in the literature for nuclear power plants

The trilogy nuclear technology-quality-reliability in nuclear energy: the interface technical regulation/industrial norm in the nuclear industry

International Nuclear Information System (INIS)

Costa, Jose Ribeiro da

1995-01-01

In this paper, it is tried to find out a compatibility among Regulations (mandatory) documents governing Quality Assurance Requirements for the Nuclear Industry (like IAEA/50-C-QA, IAEA/50-SG-QA1, IAEA/50-SG-QA7, and others), with similar documents prescribing same requirements for COnventional Industry (like ISO/900 Series), using the technical support of the prescriptions contained in the IAEA/TR-328 documents. Harmonization and compatibility of these documents is a great deal for Industries engaged -directly or indirectly - in the Nuclear Technology, taking into account that such compatibility can avoid troubles for already ISO/9000 Series Certified Industries in the fulfillment of its contract requirements in the nuclear field. Its also represents in that field a symbiosis between Technical Regulations (mandatory) and Voluntary Standards (Industrial, Consensual Standards). (author). 7 refs., 1 fig., 1 tab

Co-operative development of nuclear safety regulations, guides and standards based on NUSS

International Nuclear Information System (INIS)

Pachner, J.; Boyd, F.C.; Yaremy, E.M.

1985-01-01

A major need of developing Member States building nuclear power plants (NPPs) of foreign origin is to acquire a capability to regulate such nuclear plants independently. Among other things, this requires the development of national nuclear safety regulations, guides and standards to govern the development and use of nuclear technology. Recognizing the importance and complexity of this task, it seems appropriate that the NPP-exporting Member States share their experience and assist the NPP-importing Member States in the development of their national regulations and guides. In 1983, the Atomic Energy Control Board and Atomic Energy of Canada Ltd. conducted a study of a possible joint programme involving Canada, an NPP-importing Member State and the IAEA for the development of the national nuclear safety regulations and guides based on NUSS documents. During the study, a work plan with manpower estimates for the development of design regulations, safety guides and a guide for regulatory evaluation of design was prepared as an investigatory exercise. The work plan suggests that a successful NUSS implementation in developing Member States will require availability of significant resources at the start of the programme. The study showed that such a joint programme could provide an effective mechanism for transfer of nuclear safety know-how to the developing Member States through NUSS implementation. (author)

The Competence Promoting by NNSA for Keeping High Level Nuclear Safety: The Corner Stone of the Nuclear Safety Regulation Edifice

International Nuclear Information System (INIS)

Hu, L.

2016-01-01

Facing the fast development of the nuclear power industry and the application of radioactive sources, The MEP(NNSA) is endeavoured to promoting its competency, including: complementing the law system, training and recruiting staff to keep a capable team, constructing the R&D base to keep the basic capability, promoting safety culture both for the industry and the regulator. After the Fukushima nuclear accident, the MEP(NNSA) planned to construct R&D base, in which the Platform Nuclear Safety Monitoring and Emergency Responding, the Platform of Safety Technology of PWR Testing, the Laboratory of Safety Management Technology of Nuclear Waste Verification, the Laboratory of Environmental Radiation Monitoring and the Center of International Cooperation are included. On the other hand, the MEP(NNSA) issued Chinese nuclear safety culture policy declaration in 2014, and carried out a large scale Specialized Action for Nuclear Safety Promotion to promote the nuclear safety culture both for the industry and herself. For the nuclear regulator, It is essential to conduct the competence promoting by both “hardware” and “software”, the former is the material foundation of regulation authority, which will be effectively functioning under the facilitating of the latter. (author)

The regulations concerning refining business of nuclear source material and nuclear fuel materials

International Nuclear Information System (INIS)

1987-01-01

Regulations specified here cover application for designation of undertakings of refining (spallation and eaching filtration facilities, thickening facilities, refining facilities, nuclear material substances or nuclear fuel substances storage facilities, waste disposal facilities, etc.), application for permission for alteration (business management plan, procurement plan, fund raising plan, etc.), application for approval of merger (procedure, conditions, reason and date of merger, etc.), submission of report on alteration (location, structure, arrangements processes and construction plan for refining facilities, etc.), revocation of designation, rules for records, rules for safety (personnel, organization, safety training for employees, handling of important apparatus and tools, monitoring and removal of comtaminants, management of radioactivity measuring devices, inspection and testing, acceptance, transport and storage of nuclear material and fuel, etc.), measures for emergency, submission of report on abolition of an undertaking, submission of report on disorganization, measures required in the wake of revocation of designation, submission of information report (exposure to radioactive rays, stolen or missing nuclear material or nuclear fuel, unusual leak of nuclear fuel or material contaminated with nuclear fuel), etc. (Nogami, K.)

Development in France of nuclear safety technical regulations and standards used in the licensing procedure

International Nuclear Information System (INIS)

Lebouleux, P.

1983-04-01

Initially, the Commissariat a l'Energie Atomique was the overall structure which encompassed all nuclear activities in France, including those connected with radiological protection and nuclear safety. As other partners appeared, the Authorities have laid down national regulations relative to nuclear installations since 1963. These regulations more particularly provide for the addition of prescriptions with which the applicant must comply to obtain the necessary licenses and the establishment of General Technical Regulations pertaining to nuclear safety. The technical regulation related to nuclear safety in France is made of a set of regulation texts, of a different nature, that define the requirements for the construction, commissioning and operation of nuclear facilities. Simultaneously, the safety authorities (Service Central de Surete des Installations Nucleaires: SCSIN) issue recommendations or guides which are not strictly speaking regulations in the juridical sense; they are called ''Regles Fondamentales de Surete'' (RFS). The RFS set up and detail the conditions, the respect of which is deemed to be complying with the French regulation practice, for the subject to which they relate. Their purpose is to make known rules judged acceptable by safety authorities, thus making the safety review easier. A RFS, or a letter, can also give the result of the examination of the constructor and operator codes (RCC) by safety authorities

Regulations and guides for nuclear power plants

International Nuclear Information System (INIS)

1984-01-01

The purpose of the present Guide is to provide information, guidance and recommendations to assist the regulatory body of a Member State in establishing its own regulations and guides. It discusses the purpose, the method and procedure of establishment, and the content and legal status of these documents, and it explains how to use the Codes of Practice and Safety Guides issued by the IAEA under the Nuclear Safety Standards (NUSS) programme. Certain aspects of how to use other international standards and appropriate regulations and guides from other countries are discussed

Legal status of minister's notices and technology standards of 'Korea institute of nuclear safety'(KINS) to regulate nuclear safety

International Nuclear Information System (INIS)

Jung, S. K.; Jung, M. M.; Kim, S. W.; Jang, K. H.; Oh, B. J.

2003-01-01

Concerning nuclear safety or technology standards, each of 'notices' issued by minister of science and technology(MOST) empowered by law of its regulation is obviously forceful as a law, if not all. But the standards made by the chief of Korea institute of nuclear safety(KINS) to meet the tasks entrusted to KINS by MOST is only conditionally forceful as a law, that is, on the condition that law or regulation empowered the chief of KINS to make nuclear safety and/or technology standards

Dynamic regulation of Drosophila nuclear receptor activity in vivo.

Science.gov (United States)

Palanker, Laura; Necakov, Aleksandar S; Sampson, Heidi M; Ni, Ruoyu; Hu, Chun; Thummel, Carl S; Krause, Henry M

2006-09-01

Nuclear receptors are a large family of transcription factors that play major roles in development, metamorphosis, metabolism and disease. To determine how, where and when nuclear receptors are regulated by small chemical ligands and/or protein partners, we have used a 'ligand sensor' system to visualize spatial activity patterns for each of the 18 Drosophila nuclear receptors in live developing animals. Transgenic lines were established that express the ligand binding domain of each nuclear receptor fused to the DNA-binding domain of yeast GAL4. When combined with a GAL4-responsive reporter gene, the fusion proteins show tissue- and stage-specific patterns of activation. We show that these responses accurately reflect the presence of endogenous and exogenously added hormone, and that they can be modulated by nuclear receptor partner proteins. The amnioserosa, yolk, midgut and fat body, which play major roles in lipid storage, metabolism and developmental timing, were identified as frequent sites of nuclear receptor activity. We also see dynamic changes in activation that are indicative of sweeping changes in ligand and/or co-factor production. The screening of a small compound library using this system identified the angular psoralen angelicin and the insect growth regulator fenoxycarb as activators of the Ultraspiracle (USP) ligand-binding domain. These results demonstrate the utility of this system for the functional dissection of nuclear receptor pathways and for the development of new receptor agonists and antagonists that can be used to modulate metabolism and disease and to develop more effective means of insect control.

Proceedings of the CISDEN meeting on present problems in Community and international law in the nuclear field

International Nuclear Information System (INIS)

1981-06-01

These proceedings of the meeting of the Italian Nuclear Law Study Centre reproduce in full the three papers presented, together with the ensuing discussions. The papers respectively deal with the recent Constitutional Court Decision opposing a referendum on nuclear power plant site selection; international contracts -private autonomy and State law- and the incidence of recent trends on nuclear contracts; problems in relation to the entry into force of the 1980 Euratom radiation protection directive and the revision of relevant Italian regulations. (NEA) [fr

Regulation on control of nuclear materials of the 31 Oct 1986

International Nuclear Information System (INIS)

1986-01-01

The new regulation on accounting for and control of nuclear materials was issued on 31 October 1986 and put into force on 1 February 1987. The following provisions are included: aim and scope, responsibility for nuclear material accounting and control, rights and obligations of the nuclear material control officer, licensing, facility's instructions for nuclear material control, accounting, records, reporting, unusual events, inspections, nuclear material transfers, exemptions and termination of IAEA safeguards, final provisions, and definitions of terms

IAEA Assistance to developing countries in the regulation of nuclear installations

International Nuclear Information System (INIS)

Phuong, H.V.

1977-01-01

The paper analyses the IAEA assistance to developing countries in the regulation of nuclear installations. The projected growth of nuclear power both in industrialised and developing IAEA Member States has led to a reassessment of the role that the Agency should play pursuant to its statutory obligation in the area of nuclear safety. Accelerated work was begun nearly 3 years ago to establish a wide range of recommendations essential in matters of nuclear power plant safety so as to provide an internationally acceptable body of basic criteria and minimum requirements. In recent years the IAEA has increasingly provided advisory services to developing countries for the elaboration of enabling legislation; also intensive training programmes covering specific nuclear safety and regularoty topics have been carried out through special training courses and conducted in co-operation with host countries with extensive nuclear experience and appropriate training facilities. Experience has shown that these services have been of practical help to national authorities in providing guidance and initiatives for speeding up the process of framing laws and regulations. (NEA) [fr

R and D perspectives on the advanced nuclear safety regulation system

International Nuclear Information System (INIS)

Lee, Chang Ju; Ahn, Sang Kyu; Park, Jong Seuk; Chung, Dae Wook; Han, Sang Hoon; Lee, Jung Won

2009-01-01

As current licensing process is much desired to be optimized both plant safety and regulatory efficiency, an advanced safety regulation such as risk informed regulation has been come out. Also, there is a need to have a future oriented safety regulation since a lot of new reactors are conceptualized. Keeping pace with these needs, since early 2007, Korean government has launched a new project for preparing an advanced and future oriented nuclear safety regulation system. In order to get practical achievements, the project team sets up such specific research objectives for the development of: implementation program for graded regulation using risk and performance information; multi purpose PSA models for regulatory uses; a technology neutral regulatory framework for future innovative reactors; evaluation procedure of proliferation resistance; and, performance based fire hazard analysis method and evaluation system. This paper introduces major R and D outputs of this project, and provides some perspectives for achieving effectiveness and efficiency of the nuclear regulation system in Korea

R and D perspectives on the advanced nuclear safety regulation system

Energy Technology Data Exchange (ETDEWEB)

Lee, Chang Ju; Ahn, Sang Kyu; Park, Jong Seuk; Chung, Dae Wook [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of); Han, Sang Hoon; Lee, Jung Won [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2009-04-15

As current licensing process is much desired to be optimized both plant safety and regulatory efficiency, an advanced safety regulation such as risk informed regulation has been come out. Also, there is a need to have a future oriented safety regulation since a lot of new reactors are conceptualized. Keeping pace with these needs, since early 2007, Korean government has launched a new project for preparing an advanced and future oriented nuclear safety regulation system. In order to get practical achievements, the project team sets up such specific research objectives for the development of: implementation program for graded regulation using risk and performance information; multi purpose PSA models for regulatory uses; a technology neutral regulatory framework for future innovative reactors; evaluation procedure of proliferation resistance; and, performance based fire hazard analysis method and evaluation system. This paper introduces major R and D outputs of this project, and provides some perspectives for achieving effectiveness and efficiency of the nuclear regulation system in Korea.

Nuclear Regulator Knowledge Management in a Dynamic Nuclear Industry Environment

International Nuclear Information System (INIS)

Turner, J.

2016-01-01

Full text: The paper outlines the experiences to date in developing mature knowledge management within the UK’s nuclear regulatory body The Office for Nuclear Regulation (ONR). In 2010 concerns over the loss of knowledge due to the age profile within the organization instigated a review of knowledge management and the development of a knowledge management initiative. Initially activities focused on knowledge capture but in order to move to through life knowledge transfer, knowledge management was then aligned with organizational resilience initiatives. A review of progress highlighted the need to better engage the whole organization to achieve the desired level of maturity for knowledge management. Knowledge management activities now cover organizational culture and environment and all aspects of organizational resilience. Benefits to date include clear understanding of core knowledge requirements, better specifications for recruitment and training and the ability to deploy new regulatory approaches. During the period of implementing the knowledge management programme ONR undertook several organizational changes in moving to become a separate statutory body. The UK nuclear industry was in a period of increased activity including the planning of new nuclear reactors. This dynamic environment caused challenges for embedding knowledge management within ONR which are discussed in the paper. (author

Regulated portals of entry into the cell

Science.gov (United States)

Conner, Sean D.; Schmid, Sandra L.

2003-03-01

The plasma membrane is the interface between cells and their harsh environment. Uptake of nutrients and all communication among cells and between cells and their environment occurs through this interface. `Endocytosis' encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane. It controls entry into the cell and has a crucial role in development, the immune response, neurotransmission, intercellular communication, signal transduction, and cellular and organismal homeostasis. As the complexity of molecular interactions governing endocytosis are revealed, it has become increasingly clear that it is tightly coordinated and coupled with overall cell physiology and thus, must be viewed in a broader context than simple vesicular trafficking.

Managing for safety and safety culture within the UK nuclear industry. A regulator's perspective

International Nuclear Information System (INIS)

Tyrer, M.J.

2002-01-01

This paper outlines the basis of the legal system for the regulation of health and safety at work within the United Kingdom (UK), and in particular, the regulation of the nuclear industry. The framework, formulated by the regulator, which has been published as a practical guide for directors, managers, health and safety professionals and employee representatives for the successful management of health and safety is explained. This guidance, however, concentrates, to a large extent, on management systems and only addresses in part the types of issues, such as behaviours, values, attitudes and beliefs which contribute to the safety culture of an organization. The regulator of the UK nuclear industry has considered research, and other work, carried out by several organizations in this area, notably the Advisory Committee on the Safety of Nuclear Installations (ACSNI) and the International Atomic Energy Agency (IAEA), and produced its own framework for managing for safety at nuclear installations. As a regulator, the Health and Safety Executive (HSE), and its inspectorate responsible for regulation of the nuclear industry, HM Nuclear Installations Inspectorate (HMNII), are not the appropriate organization to assess the safety culture of an organization, but positively encourage organizations to both carry out this assessment themselves and to monitor their performance. To this end, HSE has developed, and made available, the Health and Safety Climate Tool which is aimed at providing organizations with information which can be used as part of a continuous improvement process. (author)

Controlling the atom: The beginnings of nuclear regulation, 1946-1962

International Nuclear Information System (INIS)

Mazuzan, G.T.; Walker, S.

1985-01-01

The authors trace the political, legislative, technological, and administrative history of nuclear regulation in this country. Many groups have been involved in the regulatory process, but the Atomic Energy Commission (precursor of the Nuclear Regulatory Commission) had the primary mandate for protecting public health and safety from the nonmilitary uses of nuclear energy. The AEC had other important statutory functions, and the authors examine them in terms of how they influenced the agency's regulatory role

Assessment of policy issues in nuclear safety regulation according to circumstantial changes

Energy Technology Data Exchange (ETDEWEB)

Chang, Soon Heung; Chang, Soon Heung; Lee, Byong Ho; Baek, Won Pil; Roh, Chang Hyun; Lee, Kwang Gu; Kim, Hong Chae; Lee, Yong Ho [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1999-03-15

The objective of the work is to assess various issues in nuclear safety regulation in consideration of circumstantial changes. Emphasis is given to the safety of operating NPPs. It is concluded that the Periodic Safety Review (PSR) should be implemented in Korea as soon as possible, in harmonization with the regulation for life extension of NPPs. The IAEA guidelines, including 10 year intervals and 11 safety factors, should be used as the basic guidelines. Efforts are also required to cope with other circumstantial changes such as the establishment of International Nuclear Regulators Association (INRA)

Regulation of signaling genes by TGFβ during entry into dauer diapause in C. elegans

Directory of Open Access Journals (Sweden)

Patterson Garth I

2004-09-01

roles for several members of these large gene families. Unlike in adults, most genes with putative DAF-16 binding sites are upregulated during dauer entry, suggesting that DAF-16 has different activity in dauer versus adult metabolism and aging. However, our observation that the position of putative DAF-16 binding sites is correlated with the direction of regulation suggests a novel method of achieving gene-specific regulation from a single pathway. We see evidence of TGFβ-mediated regulation of several other classes of regulatory genes, and we discuss possible functions of these genes in dauer formation.

Education and Training of Safety Regulation for Nuclear Safety Infrastructure: Its Necessity and Unique Features

International Nuclear Information System (INIS)

Choi, Young Sung; Choi, Young Joon; Lee, Jae Cheon

2009-01-01

Faced with global warming and electricity demands, countries over the world recognize the comparative advantages of nuclear energy. It is estimated that about 300 nuclear power plants (NPPs) expect to be constructed until 2030 worldwide. In addition, according to the IAEA, approximately 20 new countries might have their first NPP in operation by 2030 in the high projection compared with bout 5 new countries in the low projection. When introducing nuclear power, the implementation of an appropriate infrastructure to address all of the relevant issues is a central concern of international community. In particular, nuclear power program requires, at an earlier stage than when construction starts, the development of a legal and regulatory framework and training of regulators and safety experts whose combined knowledge adequately covers all areas of nuclear safety and regulation applied at a NPP construction and operation. As an essential component of such human resource development, special attention was paid to the provision of education and training to regulators of which countries plan to introduce NPPs. In term of education theory, safety regulation has some unique features in learning and teaching, which are different from those of nuclear engineering or development. This paper overviews nuclear safety infrastructure, explores the roles of exporting countries, and presents features and components in education of nuclear safety regulation

Nuclear regulations: current status and proposed initiatives

International Nuclear Information System (INIS)

Domondon, D.B.; Valdezco, E.M.; Mateo, A.J.; Parami, V.K.

1996-01-01

The science Act of 1958 created the Philippine Atomic Energy Commission, presently known as the Philippine Nuclear Research Institute (PNRI), under the Department of Science and Technology (DOST). The PNRI is tasked with the dual role of promotion and control of the peaceful applications of atomic energy. To carry its mandate of regulation and control on the use of raioisotopes in various fields, the PNRI had promulgated and issued specific regulations known as the Code of PNRI regulations. This paper summarizes the activities undertaken by PNRI in the continuing process of review and subsequent revisions of the Code of PNRI regulations and related guidance documents. It highlights proposed modifications in the present regulations in an attempt to adopt the new international basic safety standards, the practical problems and related issues attendant to the implementation of these new standards, among others. In line with the overall objective of PNRI to ensure the safe application of nuclear energy and radiation technology in various fields, the institute conducted a series of regulatory information conferences to provide an opportunity for members of the regulatory staff of the PNRI and licenses to discuss safety initiatives and regulatory issues. This paper will also provide an in-depth assessment of the lessons learned from these conferences which were conducted by sector or by specific applications for a more focused approach, e.g. radiopharmaceuticals, industrial radiography, research, among others. Licensees' feedback on the PNRI regulatory process are presented as part of the overall objective of enhancing the operational experiences of the licensing, review and evaluation group as well as that of inspection, enforcement and compliance. Several proposed initiatives for consideration of the PNRI to further strengthen its regulatory functions are also briefly outlined. (author)

A study on the establishment of a nuclear regulators' association in the Northeast Asia

International Nuclear Information System (INIS)

Shin, Won Ky; Park, Y. S.; Lee, H. J.; Park, D. K.; Choi, K. S.; Park, C. H.; Hwang, S. C.; Do, K. S.; Choi, Y. S.

2001-12-01

It is desirable to make joint efforts among northeast countries in order to assure nuclear safety in northeast Asia where nuclear power development has been active. In this regard, through this study, it is developed the draft for the establishment of a regional cooperative mechanism in the field of nuclear safety regulation in this region. This will be utilized as a basic references to plan and conduct regional cooperation in the field of nuclear safety regulation in this region. Through this study, the status of multilateral cooperative mechanisms in nuclear safety field, domestic and international nuclear safety trends, and nuclear safety cooperation status in this region are investigated. Based on this investigation, the draft for the establishment of the Nuclear Regulators Meeting in the Northeast Asia (NUREMA) and its implementation plan are developed. If the NUREMA is successfully established and operated, it will serve as a central basis for exchanging regulatory related information, experience, and techniques, etc., which will strengthen domestic and regional nuclear safety. It is desirable to strengthen the MOST∼NNSA∼METI Tripartite Meeting on a step by step basis for the next few years (4 - 5 years) and finally establish a multilateral cooperative mechanism like NUREMA

Recent developments in the regulation of nuclear transportation

International Nuclear Information System (INIS)

Grella, A.W.

1978-01-01

In the past four years, almost all nations and international or intergovernmental transport organizations have effected transitions from the 1967 to 1973 IAEA standards as their basis for regulatory requirements for the safe transport of radioactive materials. One major exception to this transition is the USA itself, where this transition has not yet taken place. Major amendments to revise 49 CFR Parts 100-199 of the Department of Transportation regulations and 10 CFR Part 71 of the Nuclear Regulatory Commission regulations are required to effect this transition. The notices of proposed rulemaking to effect this transition in the USA are expected to be published by DOT and NRC concurrently sometime in 1978. Final amendments can be expected later, after the public comment period on the notices and considerations of those comments. This paper summarizes the status of current thinking on US adoption of the 1973 IAEA standards, as well as the status of adoption of those standards by international intergovernmental organizations, such as the Intergovernmental Maritime Consultative Organization, International Civil Aviation Organization, etc. A number of the differences between the expected US regulations and other regulations based on the 1973 IAEA standards are explained. This paper also discusses a number of other events or matters which have been taking place in the US in the past four years which have or may have an effect on transport of nuclear materials and its regulation, including air transport of plutonium, rail transport of spent fuel and other regulations by state or political subdivisions. The paper also discusses changes to US regulations accomplished in the past four years, which are not related to 1973 IAEA standards, as well as some other possible areas where regulatory proposals might be anticipated, such as control of radiation exposures to certain transport workers and other matters

Nuclear regulation in the 1980s - a leadership role

International Nuclear Information System (INIS)

Asselstine, J.K.

1983-01-01

An overview of cooperation between the Nuclear Regulatory Commission (NRC) and the nuclear industry cites the Institute of Nuclear Power Operations (INPO) as a model for other cooperative efforts, both in determining the need for and the appropriateness of regulatory requirements. The author addresses three needs of nuclear regulation that will be significant during the 1980s: to adapt our regulatory program to a changing workload; to address safety issues, and particularly the development of new safety requirements, for nuclear plants; and to modernize and improve the licensing process. Steps to improve licensing procedures could include standardization, the resolution of design issues before the start of construction, redefinition of the hearing process, limitations of later modifications, stable commission decision making authority, and recognition of the commission's authority to consider economic costs in making regulatory decisions

The Process of Legal Drafting Regulation in the Development of the Nuclear Power Plant in Indonesia

International Nuclear Information System (INIS)

Amil Mardha

2009-01-01

In Indonesia, the process of legal drafting to establish the regulation is based on the Act No. 10 Year 2004 on the Establishment of Legislation. The process shall comply with the constitutional and institutional requirements of national political and legal system. In drafting the development of the regulation of nuclear energy, BAPETEN has been involving some other agencies or other related government agencies, and stakeholders such as utility, academic institutions, and publics. In general, in the process of legal drafting, international publications or other country regulations can be a reference and adopted. In the establishment of the regulations of nuclear energy, BAPETEN has issued some Government Regulations and Chairman Regulations of BAPETEN. For nuclear safety of NPP, the regulations have not been completed yet, but some regulations related in the area of siting of NPP have been already available. In this paper, it is discussed the process of the establishment of legislation and of the legal drafting nuclear regulation of NPP, and the current status of NPP regulations. (author)

Operating Nuclear Power Stations in a Regulated Cyber Security Environment

Energy Technology Data Exchange (ETDEWEB)

Dorman, E.

2014-07-01

The United States Nuclear Regulatory Commission (NRC) issued 10CFR73.54 to implement a regulated Cyber Security Program at each operating nuclear reactor facility. Milestones were implemented December 31, 2012 to mitigate the attack vectors for the most critical digital assets acknowledged by the industry and the NR C. The NRC inspections have begun. The nuclear Cyber Security Plan, implemented by the site Cyber Security Program (Program), is an element of the operating license at each facility. (Author)

Operating Nuclear Power Stations in a Regulated Cyber Security Environment

International Nuclear Information System (INIS)

Dorman, E.

2014-01-01

The United States Nuclear Regulatory Commission (NRC) issued 10CFR73.54 to implement a regulated Cyber Security Program at each operating nuclear reactor facility. Milestones were implemented December 31, 2012 to mitigate the attack vectors for the most critical digital assets acknowledged by the industry and the NR C. The NRC inspections have begun. The nuclear Cyber Security Plan, implemented by the site Cyber Security Program (Program), is an element of the operating license at each facility. (Author)

Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus.

Directory of Open Access Journals (Sweden)

Mohammad F Saeed

2008-08-01

Full Text Available The phosphoinositide-3 kinase (PI3K pathway regulates diverse cellular activities related to cell growth, migration, survival, and vesicular trafficking. It is known that Ebola virus requires endocytosis to establish an infection. However, the cellular signals that mediate this uptake were unknown for Ebola virus as well as many other viruses. Here, the involvement of PI3K in Ebola virus entry was studied. A novel and critical role of the PI3K signaling pathway was demonstrated in cell entry of Zaire Ebola virus (ZEBOV. Inhibitors of PI3K and Akt significantly reduced infection by ZEBOV at an early step during the replication cycle. Furthermore, phosphorylation of Akt-1 was induced shortly after exposure of cells to radiation-inactivated ZEBOV, indicating that the virus actively induces the PI3K pathway and that replication was not required for this induction. Subsequent use of pseudotyped Ebola virus and/or Ebola virus-like particles, in a novel virus entry assay, provided evidence that activity of PI3K/Akt is required at the virus entry step. Class 1A PI3Ks appear to play a predominant role in regulating ZEBOV entry, and Rac1 is a key downstream effector in this regulatory cascade. Confocal imaging of fluorescently labeled ZEBOV indicated that inhibition of PI3K, Akt, or Rac1 disrupted normal uptake of virus particles into cells and resulted in aberrant accumulation of virus into a cytosolic compartment that was non-permissive for membrane fusion. We conclude that PI3K-mediated signaling plays an important role in regulating vesicular trafficking of ZEBOV necessary for cell entry. Disruption of this signaling leads to inappropriate trafficking within the cell and a block in steps leading to membrane fusion. These findings extend our current understanding of Ebola virus entry mechanism and may help in devising useful new strategies for treatment of Ebola virus infection.

The law for the regulations of nuclear source materials, nuclear fuel materials and reactors

International Nuclear Information System (INIS)

1977-01-01

Concerning refining, fabrication and reprocessing operations of such materials as well as the installation and operation of reactors, necessary regulations are carried out. Namely, in case of establishing the business of refining, fabricating and reprocessing nuclear materials as well as installing nuclear reactors, applications for the permission of the Prime Minister and the Minister of International Trade and Industry should be filed. Change of such operations should be permitted after filing applications. These permissions are retractable. As regards the reactors installed aboard foreign ships, it must be reported to enter Japanese waters and the permission by the Prime Minister must be obtained. In case of nuclear fuel fabricators, a chief technician of nuclear fuel materials (qualified) must be appointed per each fabricator. In case of installing nuclear reactors, the design and methods of construction should be permitted by the Prime Minister. The standard for such permission is specified, and a chief engineer for operating reactors (qualified) must be appointed. Successors inherit the positions of ones who have operated nuclear material refining, fabrication and reprocessing businesses or operated nuclear reactors. (Rikitake, Y.)

State regulation of nuclear sector: comparative study of Argentina and Brazil models

International Nuclear Information System (INIS)

Monteiro Filho, Joselio Silveira

2004-08-01

This research presents a comparative assessment of the regulation models of the nuclear sector in Argentina - under the responsibility of the Autoridad Regulatoria Nuclear (ARN), and Brazil - under the responsibility of Comissao Nacional de Energia Nuclear (CNEN), trying to identify which model is more adequate aiming the safe use of nuclear energy. Due to the methodology adopted, the theoretical framework resulted in criteria of analysis that corresponds to the characteristics of the Brazilian regulatory agencies created for other economic sector during the State reform staring in the middle of the nineties. Later, these criteria of analysis were used as comparison patterns between the regulation models of the nuclear sectors of Argentina and Brazil. The comparative assessment showed that the regulatory structure of the nuclear sector in Argentina seems to be more adequate, concerning the safe use of nuclear energy, than the model adopted in Brazil by CNEN, because its incorporates the criteria of functional, institutional and financial independence, competence definitions, technical excellence and transparency, indispensable to the development of its functions with autonomy, ethics, exemption and agility. (author)

Working together with regulators on nuclear sites

International Nuclear Information System (INIS)

Holloway, N.J.

2004-01-01

A scheme for earlier and clearer communications with the Health and Safety Executive (HSE) and the Environment Agency (EA) on jointly regulated issues has been developed across the nuclear industry over the past two years. The matched pair of industry and regulators' 'Working Together' documents was published in January 2003. In the United Kingdom Atomic Energy Authority (UKAEA), the scheme is being put into practice through the issue of Initial Regulatory Notifications (IRN) of various projects and issues, to capture key regulatory topics and prompt regulators' initial responses. The IRN may be based on a safety and environment overview report or may be a precursor to it. Positive responses, in line with the Working Together documents, were received from HSE and the EA, following receipt of the first three UKAEA IRNs. (author)

Negative transcriptional regulation of mitochondrial transcription factor A (TFAM) by nuclear TFAM

International Nuclear Information System (INIS)

Lee, Eun Jin; Kang, Young Cheol; Park, Wook-Ha; Jeong, Jae Hoon; Pak, Youngmi Kim

2014-01-01

Highlights: • TFAM localizes in nuclei and mitochondria of neuronal cells. • Nuclear TFAM does not bind the Tfam promoter. • Nuclear TFAM reduced the Tfam promoter activity via suppressing NRF-1 activity. • A novel self-negative feedback regulation of Tfam gene expression is explored. • FAM may play different roles depending on its subcellular localizations. - Abstract: The nuclear DNA-encoded mitochondrial transcription factor A (TFAM) is synthesized in cytoplasm and transported into mitochondria. TFAM enhances both transcription and replication of mitochondrial DNA. It is unclear, however, whether TFAM plays a role in regulating nuclear gene expression. Here, we demonstrated that TFAM was localized to the nucleus and mitochondria by immunostaining, subcellular fractionation, and TFAM-green fluorescent protein hybrid protein studies. In HT22 hippocampal neuronal cells, human TFAM (hTFAM) overexpression suppressed human Tfam promoter-mediated luciferase activity in a dose-dependent manner. The mitochondria targeting sequence-deficient hTFAM also repressed Tfam promoter activity to the same degree as hTFAM. It indicated that nuclear hTFAM suppressed Tfam expression without modulating mitochondrial activity. The repression required for nuclear respiratory factor-1 (NRF-1), but hTFAM did not bind to the NRF-1 binding site of its promoter. TFAM was co-immunoprecipitated with NRF-1. Taken together, we suggest that nuclear TFAM down-regulate its own gene expression as a NRF-1 repressor, showing that TFAM may play different roles depending on its subcellular localizations

Report on the NRA workshop ''investing in trust, nuclear regulators and the public''

International Nuclear Information System (INIS)

Laaksonen, J.

2002-01-01

The workshop was held in Paris on the 29. November - 1. December 2000. Its objective was well captured in the title: Investing in Trust, Nuclear Regulators and the Public. The general public is concerned with the risks involved in the use of nuclear power, and has a legitimate desire for reliable and impartial information. The nuclear regulators have answers, but in order to fulfill the information needs of the general public and their elected representatives, they need to be regarded trustworthy. Most of the about 80 participants were from nuclear regulatory bodies and radiation protection agencies. The discussions gave regulators an opportunity to change views and experiences on how to gain trust in their openness and honesty, and in their will and capability to protect public interests. The weight given to the topic was indicated by participation of nine heads of national regulatory bodies, among them top regulators from four countries with largest nuclear programmes: the USA, Japan, France, and the UK. The number of papers presented was 33, and their topics were considered well chosen by the organizing committee. Throughout the workshop 'posters' were available; these were electronic links to the web sites of the attending regulatory bodies. Proceedings of the workshop will be published during the first half of 2001. (author)

Strengthening the Convention on the Physical Protection of Nuclear Materials and Nuclear Facilities Regime: A Path Forward

International Nuclear Information System (INIS)

Pitts-Kiefer, S.; Nalabandian, M.

2017-01-01

With entry into force of the 2005 Amendment to the Convention on the Physical Protection of Nuclear Material (CPPNM) on May 8, 2016, and the culmination of the Nuclear Security Summits (NSS), the Convention on the Physical Protection of Nuclear Materials and Nuclear Facilities (CPP), as the amended convention is now known, can play an increasingly important role in efforts to strengthen the international nuclear security architecture. The CPP significantly enhances the international legal framework for nuclear security by expanding the scope of physical protection requirements and providing a direct linkage to International Atomic Energy Agency (IAEA) nuclear security guidance through incorporation of the Fundamental Principles.The CPP’s entry into force requires states parties to submit reports to the IAEA under Article 14 informing the IAEA of its laws and regulations giving effect to the convention—states parties were required to do so under the original CPPNM, but the scope of the reports will need to expand to reflect the expanded scope of the convention. Reporting builds confidence in the effectiveness of states’ security. In addition, entry into force of the CPP requires the IAEA, under Article 16, to convene a review conference in five years to assess the implementation and adequacy of the convention “in light of the then prevailing situation.” The review conference will provide an opportunity for states parties to assess the status of nuclear security progress and will provide a forum for dialogue on how to strengthen the global architecture and address remaining gaps in the system. Article 16 also provides for additional review conferences at periods of at least five years if requested by a majority of states parties. Regular review conferences would be an important mechanism for sustaining attention on nuclear security and ensuring continued nuclear security progress. For the CPP to fulfill its potential to play an important role in

76 FR 15841 - Entry of Merchandise

Science.gov (United States)

2011-03-22

... DEPARTMENT OF HOMELAND SECURITY Bureau of Customs and Border Protection DEPARTMENT OF THE TREASURY 19 CFR Part 141 Entry of Merchandise CFR Correction In Title 19 of the Code of Federal Regulations, Parts 141 to 199, revised as of April 1, 2010, on page 6, the second general authority citation for part...

Resolution 62/96 Regulation for the accounting and control of the nuclear materials

International Nuclear Information System (INIS)

1996-01-01

The present Regulation is a complementary disposition of the ordinance number 208 of May 24 National System of Accounting and Control of Nuclear Materials and it has as objective to establish the relative norms to this System. As for the responsibilities it establish that the National Center of Nuclear Security (CNSN) it is the responsible for the execution from the relative tasks to the National System of Accounting and Control of Nuclear Materials. It establishes the regulations for the following aspects: licenses and authorizations for the transportation of the nuclear material and important components, Of the ceasing of the Accounting and Control, Of the Accounting and Control of the Nuclear Materials, Control of the Important Components, The Inspections, International Organism of the Atomic Energy Safeguards

Investing in trust: nuclear regulators and the public

International Nuclear Information System (INIS)

2001-01-01

The workshop was held in Paris on the 29. November - 1. December 2000. Its objective was well captured in the title: Investing in Trust, Nuclear Regulators and the Public. The general public is concerned with the risks involved in the use of nuclear power, and has a legitimate desire for reliable and impartial information. It is important to convince the people that the regulatory body works for them and for their safety and is not promoting the use of nuclear energy or any other interests. A necessary condition for being trustworthy is to be well known, efficient channels are needed, a good information must be transferred to two directions, information must be easily available to the public are some important points developed in this workshop. (N.C.)

Do cost-sharing and entry deregulation curb pharmaceutical innovation?

Science.gov (United States)

Grossmann, Volker

2013-09-01

This paper examines the role of both cost-sharing schemes in health insurance systems and the regulation of entry into the pharmaceutical sector for pharmaceutical R&D expenditure and drug prices. The analysis suggests that both an increase in the coinsurance rate and stricter price regulations adversely affect R&D spending in the pharmaceutical sector. In contrast, entry deregulation may lead to higher R&D spending of pharmaceutical companies. The relationship between R&D spending per firm and the number of firms may be hump-shaped. In this case, the number of rivals which maximizes R&D expenditure per firm is decreasing in the coinsurance rate and increasing in labor productivity. Copyright © 2013 Elsevier B.V. All rights reserved.

The role of research in nuclear regulation: A Korean perspective

International Nuclear Information System (INIS)

Yoon, Won-Hyo

1997-01-01

Korea has carried out a very ambitious nuclear power program since the 1970's as part of the nation's industrialization policy. Ever since, Korea has also maintained a strong commitment to nuclear power development as an integral part of the national energy policy which aims at reducing external vulnerability and ensuring against a global fossil fuel shortage. The introduction of nuclear power into Korea has progressed through three stages: the first was a turn-key package supplied by the manufacturer; the second involved a major contractor who was responsible for project management, and design and construction was contracted out, with Korean industry becoming more involved; the third stage has seen Korean industries involved as main contractors based on experience gained from earlier plants. The success of Korea's nuclear power program depends in large part on how to insure safety. Safety has the highest priority in nuclear energy development. Public acceptance has been the most critical problem faced by the nuclear industry in Korea. The public demands the highest level of safety all through the design, construction, and operation of nuclear power plants. Korea has learned that a nuclear plant designed with well addressed safety, implementation of a well grounded QA program during construction, and operated with a proven record of safety, are the only ways to earn public support. Competent and efficient regulation with a strong safety culture and openness in all issues is the most desirable image for regulators to strive for. Korea established a ten year R ampersand D program to obtain self-reliance in nuclear technology and international competitiveness by the early 2000's in 1992. It has actively participated in coordinated research programs in safety issues with bodies including the USNRC, AECB of Canada, IAEA, and OECD/NEA

The law for the regulations of nuclear source materials, nuclear fuel materials and reactors

International Nuclear Information System (INIS)

1987-01-01

General provisions specify the purpose of the Law and definitions of terms used in it. Provisions relating to control of business management for refining cover designation of business operation, requirements for designation, permission and report of alteration, report of commencement of business operation, revocation of designation, recording, and measures for wastes. Provisions relating to control of business management for processing cover permission of operation, requirements for permission, approval of design and construction plan, inspection of facilities, report of commencement of business management, measures for maintenance, suspension of use of facilities, responsible personnel for handling nuclear fuel, and permit, obligations, etc. of responsible personnel for handing nuclear fuel. Provisions relating to control of construction and operation of nuclear reactor cover permission of construction, permission concerning nuclear reactor mounted on foreign nuclear powered ships, requirements for permission, etc. Other articles stipulate provisions relating to control of business management for reprocessing, use of nuclear fuel substances, use of materials and substances covered by international regulations, designation of inspection organizations, and other rules. (Nogami, K.)

RNA polymerase III transcription - regulated by chromatin structure and regulator of nuclear chromatin organization.

Science.gov (United States)

Pascali, Chiara; Teichmann, Martin

2013-01-01

RNA polymerase III (Pol III) transcription is regulated by modifications of the chromatin. DNA methylation and post-translational modifications of histones, such as acetylation, phosphorylation and methylation have been linked to Pol III transcriptional activity. In addition to being regulated by modifications of DNA and histones, Pol III genes and its transcription factors have been implicated in the organization of nuclear chromatin in several organisms. In yeast, the ability of the Pol III transcription system to contribute to nuclear organization seems to be dependent on direct interactions of Pol III genes and/or its transcription factors TFIIIC and TFIIIB with the structural maintenance of chromatin (SMC) protein-containing complexes cohesin and condensin. In human cells, Pol III genes and transcription factors have also been shown to colocalize with cohesin and the transcription regulator and genome organizer CCCTC-binding factor (CTCF). Furthermore, chromosomal sites have been identified in yeast and humans that are bound by partial Pol III machineries (extra TFIIIC sites - ETC; chromosome organizing clamps - COC). These ETCs/COC as well as Pol III genes possess the ability to act as boundary elements that restrict spreading of heterochromatin.

Factors affecting the entry of for-profit providers into a price regulated market for formal long-term care services: a case study from Japan.

Science.gov (United States)

Tokunaga, Mutsumi; Hashimoto, Hideki

2013-01-01

While the distinct behaviors of for-profit and non-profit providers in the healthcare market have been compared in the economic literature, their choices regarding market entry and exit have only recently been debated. Since 2000, when public Long-Term Care Insurance was introduced in Japan, for-profit providers have been able to provide formal long-term homecare services. The aim of this study is to determine which factors have affected market entry of for-profit providers under price regulation and in competition with existing non-profit providers. We used nation-wide panel data from 2002 to 2010, aggregated at the level of local public insurers (n = 1557), a basic area unit of service provision. The number of for-profit providers per elderly population in the area unit was regressed against factors related to local demand and service costs using first-difference linear regression, a fixed effects model, and Tobit regression for robustness checking. Results showed that demand (the number of eligible care recipients) and cost factors (population density and minimum wage) significantly influenced for-profit providers' choice of market entry. These findings indicate that for-profit providers will strategically choose a local market for maximizing profit. We believe that price regulation should be redesigned to incorporate quality of care and market conditions, regardless of the profit status of the providers, to ensure equal access to efficient delivery of long-term care across all regions. Copyright © 2012 Elsevier Ltd. All rights reserved.

Nuclear AMPK regulated CARM1 stabilization impacts autophagy in aged heart

International Nuclear Information System (INIS)

Li, Chen; Yu, Lu; Xue, Han; Yang, Zheng; Yin, Yue; Zhang, Bo; Chen, Mai; Ma, Heng

2017-01-01

Senescence-associated autophagy downregulation leads to cardiomyocyte dysfunction. Coactivator-associated arginine methyltransferase 1 (CARM1) participates in many cellular processes, including autophagy in mammals. However, the effect of CARM1 in aging-related cardiac autophagy decline remains undefined. Moreover, AMP-activated protein kinase (AMPK) is a key regulator in metabolism and autophagy, however, the role of nuclear AMPK in autophagy outcome in aged hearts still unclear. Hers we identify the correlation between nuclear AMPK and CARM1 in aging heart. We found that fasting could promote autophagy in young hearts but not in aged hearts. The CARM1 stabilization is markedly decrease in aged hearts, which impaired nucleus TFEB-CARM1 complex and autophagy flux. Further, S-phase kinase-associated protein 2(SKP2), responsible for CARM1 degradation, was increased in aged hearts. We further validated that AMPK dependent FoxO3 phosphorylation was markedly reduced in nucleus, the decreased nuclear AMPK-FoxO3 activity fails to suppress SKP2-E3 ubiquitin ligase. This loss of repression leads to The CARM1 level and autophagy in aged hearts could be restored through AMPK activation. Taken together, AMPK deficiency results in nuclear CARM1 decrease mediated in part by SKP2, contributing to autophagy dysfunction in aged hearts. Our results identified nuclear AMPK controlled CARM1 stabilization as a new actor that regulates cardiac autophagy. - Highlights: • AMPK-dependent CARM1 stabilization is an important nuclear mechanism in cardiac autophagy. • AMPK deficiency lead to SKP2-mediated decrease in CARM1. • AMPK–SKP2–CARM1 in the regulation of autophagy dysfunction in aged heart.

On regulation of environmental responsibility in the final stage of the nuclear fuel cycle. - Parallel regulation within the framework of Euratom and the Lisbon-treaty

International Nuclear Information System (INIS)

Erhag, Thomas

2010-09-01

In Sweden, the responsibility for the disposal of spent nuclear fuel is regulated in various laws and regulations. This means that there is an overlap between laws providing a sometimes vague and weak legal situation. Although attempts have been made to coordinate environmental and nuclear law these attempts have not succeeded. Recently, several Swedish reports have again described the fact that we have a parallel system of legal rules for the handling of spent nuclear fuel and the consequences of this. Foremost attention has been drawn to the fact that the licensing of a repository must be made both under the Nuclear Safety Act and the Environmental Code. The regulation referred to above is Swedish, and both the parallel regulation of nuclear safety-, radiation protection- and environmental- responsibility, and the relationship between such legislation, has its own Swedish history. However, Swedish legislation in all these areas is also under the influence of international regulations. This article describes the parallel regulation of nuclear safety and radiation protection issues on a European level. It shows that the division and logic found in the relationship between the Swedish laws is only partially reflected at European level. First treated is the relationship between the EC-treaty and Euratom. The article then turns to examples of regulatory responsibility for waste management and communication of information relating to license applications (environmental impact assessments) for the final disposal of spent nuclear fuel within the framework of Euratom and the EC-treaty. Finally, it discusses the implications of this type of parallel regulation for the Swedish licensing procedure

On regulation of environmental responsibility in the final stage of the nuclear fuel cycle. - Parallel regulation within the framework of Euratom and the Lisbon-treaty

Energy Technology Data Exchange (ETDEWEB)

Erhag, Thomas (Dept. of Law, Univ. of Goeteborg, Goeteborg (Sweden)), e-mail: thomas.erhag@law.gu.se

2010-09-15

In Sweden, the responsibility for the disposal of spent nuclear fuel is regulated in various laws and regulations. This means that there is an overlap between laws providing a sometimes vague and weak legal situation. Although attempts have been made to coordinate environmental and nuclear law these attempts have not succeeded. Recently, several Swedish reports have again described the fact that we have a parallel system of legal rules for the handling of spent nuclear fuel and the consequences of this. Foremost attention has been drawn to the fact that the licensing of a repository must be made both under the Nuclear Safety Act and the Environmental Code. The regulation referred to above is Swedish, and both the parallel regulation of nuclear safety-, radiation protection- and environmental- responsibility, and the relationship between such legislation, has its own Swedish history. However, Swedish legislation in all these areas is also under the influence of international regulations. This article describes the parallel regulation of nuclear safety and radiation protection issues on a European level. It shows that the division and logic found in the relationship between the Swedish laws is only partially reflected at European level. First treated is the relationship between the EC-treaty and Euratom. The article then turns to examples of regulatory responsibility for waste management and communication of information relating to license applications (environmental impact assessments) for the final disposal of spent nuclear fuel within the framework of Euratom and the EC-treaty. Finally, it discusses the implications of this type of parallel regulation for the Swedish licensing procedure

9 CFR 381.208 - Poultry products offered for entry and entered to be handled and transported as domestic; entry...

Science.gov (United States)

2010-01-01

... INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Imported Poultry Products § 381.208... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Poultry products offered for entry and....208 Section 381.208 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF...

Regulator's role in sustainability of nuclear power

International Nuclear Information System (INIS)

Bansal, Parikshat; Sinha, Soumen; Bhattacharya, Ramdas

2015-01-01

A development which is environmentally benign, economically viable as well socially acceptable is regarded as sustainable development. Nuclear power scores extremely well with the first two parameters: i.e its cost of production is competitive with that of other power sources and is considered a clean source of power as the greenhouse gas emissions and discharge of other hazardous pollutants are insignificant. However, when it comes to acceptability by the society at large, there are issues. Early shutting down of power plants like Superphénix at France, abandonment of Yucca mountain project, agitation during commissioning of KKNPP etc. are few examples where the public perception was the main reason for such actions. These events tell us about the importance of public perception in sustainability of a project or nuclear power as a whole. In this backdrop, the role of regulator to present the safety aspects in correct perspective assumes enormous significance and goes in a long way in clearing unwarranted apprehensions, thereby playing a pivotal role in sustainability of nuclear power. The nuclear regulator needs to build long lasting trust and confidence with stakeholders. Therefore it needs to be continuously in touch with public, not only during crisis but also during peace time, disseminating information on safe use of ionizing radiation and atomic energy without undue risk to the health of the people and environment. (author)

Administrative procedures for regulating construction and operation of nuclear power plants

International Nuclear Information System (INIS)

Cochaud, J.P.

1981-01-01

This article first explains that nuclear power plants in France are governed by a complex system of regulations within the framework of different laws concerning, in particular, protection of the environment, public health and workers. It then examines the administrative procedures and the licensing regime for nuclear power plants. (NEA) [fr

Regulation of spent nuclear fuel shipment: A state perspective

International Nuclear Information System (INIS)

Halstead, R.J.; Sinderbrand, C.; Woodbury, D.

1987-01-01

In 1985, the Wisconsin Department of Natural Resources (WDNR) sought to regulate rail shipments of spent nuclear fuel through the state, because federal regulations did not adequately protect the environmentally sensitive corridor along the route of the shipments. A state interagency working group identified five serious deficiencies in overall federal regulatory scheme: 1) failure to consider the safety or environmental risks associated with selected routes; 2) abscence of route-specific emergency response planning; 3) failure of the NRC to regulate the carrier of spent nuclear fuel or consider its safety record; 4) abscence of requirements for determination of need for, or the propriety of, specific shipments of spent nuclear fuel; and 5) the lack of any opportunity for meaningful public participation with respect to the decision to transport spent nuclear fuel. Pursuant to Wisconsin's hazardous substance statutes, the WDNR issues an order requiring the utility to file a spill prevention and mitigation plan or cease shipping through Wisconsin. A state trial court judge upheld the utility's challenge to Wisconsin's spill plan requirements, based on federal preemption of state authority. The state is now proposing federal legislation which would require: 1) NRC determination of need prior to approval of offsite shipment of spent fuel by the licensees; 2) NRC assessment of the potential environmental impacts of shipments along the proposed route, and comparative evaluation of alternative modes and routes; and 3) NRC approval of a route-specific emergency response and mitigation plan, including local training and periodic exercises. Additionally, the proposed legislation would authorize States and Indian Tribes to establish regulatory programs providing for permits, inspection, contingency plans for monitoring, containments, cleanup and decontamination, surveillance, enforcement and reasonable fees. 15 refs

Accounting systems for special nuclear material control. Technical report

International Nuclear Information System (INIS)

Korstad, P.A.

1980-05-01

Nuclear material accounting systems were examined and compared to financial double-entry accounting systems. Effective nuclear material accounting systems have been designed using the principles of double-entry financial accounting. The modified double-entry systems presently employed are acceptable if they provide adequate control over the recording and summarizing of transactions. Strong internal controls, based on principles of financial accounting, can help protect nuclear materials and produce accurate, reliable accounting data. An electronic data processing system can more accurately maintain large volumes of data and provide management with more current, reliable information

Distinct hydrophobic “patches” in the N- and C-tails of beta-catenin contribute to nuclear transport

Energy Technology Data Exchange (ETDEWEB)

Sharma, Manisha; Jamieson, Cara; Lui, Christina [Center for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW 2145 (Australia); Henderson, Beric R., E-mail: beric.henderson@sydney.edu.au [Center for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW 2145 (Australia)

2016-11-01

β-catenin is a key mediator of Wnt signaling and its deregulated nuclear accumulation can drive cancer progression. While the central armadillo (Arm) repeats of β-catenin stimulate nuclear entry, the N- and C-terminal “tail” sequences are thought to regulate turnover and transactivation. We show here that the N- and C-tails are also potent transport sequences. The unstructured tails of β-catenin, when individually fused to a GFP-reporter, could enter and exit the nucleus rapidly in live cells. Proximity ligation assays and pull-down assays identified a weak interaction between the tail sequences and the FG-repeats of nucleoporins, consistent with a possible direct translocation of β-catenin through the nuclear pore complex. Extensive alanine mutagenesis of the tail sequences revealed that nuclear translocation of β-catenin was dependent on specific uniformly distributed patches of hydrophobic residues, whereas the mutagenesis of acidic amino acids had no effect. Moreover, the mutation of hydrophobic patches within the N-tail and C-tail of full length β-catenin reduced nuclear transport rate and diminished its ability to activate transcription. We propose that the tail sequences can contribute to β-catenin transport and suggest a possible similar role for hydrophobic unstructured regions in other proteins. - Highlights: • We show that the N- and C-tails of beta-catenin possess nuclear transport activity. • Nuclear transport of the N- or C-tails requires specific hydrophobic amino acids. • Mutagenesis of the N-terminus diminished nuclear entry of full-length beta-catenin. • We propose the N-tail contributes to beta-catenin nuclear entry and transactivation.

Specific regulation of thermosensitive lipid droplet fusion by a nuclear hormone receptor pathway.

Science.gov (United States)

Li, Shiwei; Li, Qi; Kong, Yuanyuan; Wu, Shuang; Cui, Qingpo; Zhang, Mingming; Zhang, Shaobing O

2017-08-15

Nuclear receptors play important roles in regulating fat metabolism and energy production in humans. The regulatory functions and endogenous ligands of many nuclear receptors are still unidentified, however. Here, we report that CYP-37A1 (ortholog of human cytochrome P450 CYP4V2), EMB-8 (ortholog of human P450 oxidoreductase POR), and DAF-12 (homolog of human nuclear receptors VDR/LXR) constitute a hormone synthesis and nuclear receptor pathway in Caenorhabditis elegans This pathway specifically regulates the thermosensitive fusion of fat-storing lipid droplets. CYP-37A1, together with EMB-8, synthesizes a lipophilic hormone not identical to Δ7-dafachronic acid, which represses the fusion-promoting function of DAF-12. CYP-37A1 also negatively regulates thermotolerance and lifespan at high temperature in a DAF-12-dependent manner. Human CYP4V2 can substitute for CYP-37A1 in C. elegans This finding suggests the existence of a conserved CYP4V2-POR-nuclear receptor pathway that functions in converting multilocular lipid droplets to unilocular ones in human cells; misregulation of this pathway may lead to pathogenic fat storage.

Ukrainian Nuclear Data Centre Progress Report, 2010/11. Summary of Nuclear Data Studies by Staff of the Ukrainian Nuclear Data Centre

International Nuclear Information System (INIS)

Gritzay, O.

2011-01-01

Full text: Ukrainian Nuclear Data Centre (UkrNDC) is subdivision within the Neutron Physics Department at the Institute for Nuclear Research of the National Academy of Sciences of Ukraine. UkrNDC has 5 permanent researchers. During year under review three members of the staff were involved in experimental neutron data measurements at the Kyiv research reactor. Compilation: We continue collection and compilation of experimental neutron, charged particle and photonuclear data. Number of the EXFOR's entries sent to the NDS IAEA by UkrNDC are the following. New: for neutron data - 1 entries (32231); for charged particle data - 4 entries (D5074, D5075, D5077, D5078); for photonuclear data - 4 entries (G4030 - G4033). Improved: for neutron data - 5 entries (32217, 32219, 32222 - 32224); for charged particle data - 15 entries (D5001, D5002, D5023, D5030, D5039- D5042, D5051, D5066 - D5068, D5070, D5071, D5073); for photonuclear data - 2 entries (G4011, G4018). We realize review of compilation scope in home journals: ''Nuclear Physics and Atomic Energy''; ''Ukrainian Journal of Physics''; ''Problems of Atomic Science and Technology'', Series ''Nuclear Physics Investigations''. Collaboration: We continue our collaboration with the Nuclear Physics Department of the Taras Shevchenko National University of Kyiv. The teaching course 'Nuclear Data for Science and Technology and modern computer codes for nuclear data processing' (36 hours) has been lectured in 2010-2011 for the fifth-course students of NPD KNU. This course includes the following items: ENDF/B libraries, EXROR system, ENSDF library, the use of the PREPRO code in work with the ENDF libraries, the introduction to NJOY code system, the Network of Nuclear Reaction Data Centers and the use of the on-line services; The teaching courses 'Neutron Physics' (72 hours) and 'Neutron Physics at the Kyiv Research Reactor' (experimental work, 36 hours) are lectured in 2010-2011 for fourth-year students of NPD KNU; The teaching

ILK statement about the BMU project of updating nuclear rules and regulations

International Nuclear Information System (INIS)

2007-01-01

In 2003, the German Federal Ministry for the Environment (BMU) started its ''Updating Nuclear Rules and Regulations'' project. Proposals to this effect are currently in revision phase B. They comprise a total of eleven main topics, referred to as modules, under the heading of ''Basic Principles of Safety of Nuclear Power Plants - Safety Requirements in Accordance with the State of the Art.'' The International Nuclear Technology Committee (ILK), in 2005, dealt with the requirements to be met in an up-to-date code of nuclear rules and regulations. Its findings were published in a total of 10 recommendations. The current revision B of the 11 modules contains no discernible incorporation of these recommendations. ILK therefore once more dealt with the BMU project. A summary of its deliberations is available. ILK finds that the safety requirements to be met by nuclear power plants as outlined in the BMU draft are unable to support the implementation of the German Atomic Energy Act. In earlier statements, ILK had written that it deemed updating the code of rules and regulations desirable. The existing draft contains many elements serving this purpose, such as the inclusion of off-power conditions and a more pronounced incorporation of matters of organization and management. The main shortcomings of the present draft are identified and analyzed. (orig.)

Operating nuclear power stations in a regulated cyber security environment: a roadmap for success

Energy Technology Data Exchange (ETDEWEB)

Dorman, E., E-mail: Erik.Dorman@areva.com [AREVA Inc., Cyber Security Solutions, Charlotte, NC (United States)

2015-07-01

The United States Nuclear Regulatory Commission (NRC) issued 10CFR73.54 to implement a regulated Cyber Security Program at each operating nuclear reactor facility. Milestones were implemented December 31, 2012 to mitigate the attack vectors for the most critical digital assets acknowledged by the industry and the NRC. The NRC inspections have begun. The nuclear Cyber Security Plan, implemented by the site Cyber Security Program (Program), is an element of the operating license at each facility. The Program is designed to protect critical digital assets (CDAs) by applying and maintaining defense-in depth protective strategies to ensure the capability to detect, respond to, and recover from cyber-attacks. The Program references NEI 08-09 R. 6, the Nuclear Energy Institute Template that provides guidance for applying Cyber Security controls derived from NIST 800-53/82 and slightly modified to fit the nuclear environment. Many mature processes are in place at nuclear facilities in response to numerous regulations implemented over the past 30 years. Many of these processes such as the Physical Security Program offer protections that are leveraged to protect the functions of critical digital assets from unauthorized physical access. Other processes and technology such as engineering design control, work management and pre-job briefs, control of portable media and mobile devices, and deterministically segregated networks protect critical digital assets. By leveraging the regulated nuclear environment, integrating NIST type Cyber Security controls, and prudently deploying technology the Cyber Security posture of operating nuclear facilities supports on-demand base load electricity 24/7 with capacity factors exceeding 85%. This paper is designed to provide a glimpse into Cyber Security Programs that support safe operation and reliability in the regulated nuclear environment while supporting the on-demand base load electricity production 24/7. (author)

Operating nuclear power stations in a regulated cyber security environment: a roadmap for success

International Nuclear Information System (INIS)

Dorman, E.

2015-01-01

The United States Nuclear Regulatory Commission (NRC) issued 10CFR73.54 to implement a regulated Cyber Security Program at each operating nuclear reactor facility. Milestones were implemented December 31, 2012 to mitigate the attack vectors for the most critical digital assets acknowledged by the industry and the NRC. The NRC inspections have begun. The nuclear Cyber Security Plan, implemented by the site Cyber Security Program (Program), is an element of the operating license at each facility. The Program is designed to protect critical digital assets (CDAs) by applying and maintaining defense-in depth protective strategies to ensure the capability to detect, respond to, and recover from cyber-attacks. The Program references NEI 08-09 R. 6, the Nuclear Energy Institute Template that provides guidance for applying Cyber Security controls derived from NIST 800-53/82 and slightly modified to fit the nuclear environment. Many mature processes are in place at nuclear facilities in response to numerous regulations implemented over the past 30 years. Many of these processes such as the Physical Security Program offer protections that are leveraged to protect the functions of critical digital assets from unauthorized physical access. Other processes and technology such as engineering design control, work management and pre-job briefs, control of portable media and mobile devices, and deterministically segregated networks protect critical digital assets. By leveraging the regulated nuclear environment, integrating NIST type Cyber Security controls, and prudently deploying technology the Cyber Security posture of operating nuclear facilities supports on-demand base load electricity 24/7 with capacity factors exceeding 85%. This paper is designed to provide a glimpse into Cyber Security Programs that support safe operation and reliability in the regulated nuclear environment while supporting the on-demand base load electricity production 24/7. (author)

Internal ribosomal entry site-mediated translation is important for rhythmic PERIOD1 expression.

Directory of Open Access Journals (Sweden)

Kyung-Ha Lee

Full Text Available The mouse PERIOD1 (mPER1 plays an important role in the maintenance of circadian rhythm. Translation of mPer1 is directed by both a cap-dependent process and cap-independent translation mediated by an internal ribosomal entry site (IRES in the 5' untranslated region (UTR. Here, we compared mPer1 IRES activity with other cellular IRESs. We also found critical region in mPer1 5'UTR for heterogeneous nuclear ribonucleoprotein Q (HNRNPQ binding. Deletion of HNRNPQ binding region markedly decreased IRES activity and disrupted rhythmicity. A mathematical model also suggests that rhythmic IRES-dependent translation is a key process in mPER1 oscillation. The IRES-mediated translation of mPer1 will help define the post-transcriptional regulation of the core clock genes.

TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans.

Science.gov (United States)

McCallum, Katie C; Liu, Bin; Fierro-González, Juan Carlos; Swoboda, Peter; Arur, Swathi; Miranda-Vizuete, Antonio; Garsin, Danielle A

2016-05-01

The Caenorhabditis elegans oxidative stress response transcription factor, SKN-1, is essential for the maintenance of redox homeostasis and is a functional ortholog of the Nrf family of transcription factors. The numerous levels of regulation that govern these transcription factors underscore their importance. Here, we add a thioredoxin, encoded by trx-1, to the expansive list of SKN-1 regulators. We report that loss of trx-1 promotes nuclear localization of intestinal SKN-1 in a redox-independent, cell non-autonomous fashion from the ASJ neurons. Furthermore, this regulation is not general to the thioredoxin family, as two other C. elegans thioredoxins, TRX-2 and TRX-3, do not play a role in this process. Moreover, TRX-1-dependent regulation requires signaling from the p38 MAPK-signaling pathway. However, while TRX-1 regulates SKN-1 nuclear localization, classical SKN-1 transcriptional activity associated with stress response remains largely unaffected. Interestingly, RNA-Seq analysis revealed that loss of trx-1 elicits a general, organism-wide down-regulation of several classes of genes; those encoding for collagens and lipid transport being most prevalent. Together, these results uncover a novel role for a thioredoxin in regulating intestinal SKN-1 nuclear localization in a cell non-autonomous manner, thereby contributing to the understanding of the processes involved in maintaining redox homeostasis throughout an organism. Copyright © 2016 by the Genetics Society of America.

The peace and nuclear war dictionary

International Nuclear Information System (INIS)

Ali, S.R.

1989-01-01

The Peace and Nuclear War Dictionary is organized so that entries and supplementary data can be located easily and quickly. Items are arranged alphabetically throughout, rather than grouped into chapters. When doubtful about how to locate an entry, consult the general index. Page numbers for terms appear in the index in heavy black type; subsidiary concepts discussed within entries can be found in the index, identified by page numbers in regular type. For study purposes, numerous entries have also been subsumed under major topical headings in the index, affording the reader access to broad classes of related information. The reader can also fully explore a topic by employing the extensive cross-references included in all entries. Many entries can be found as subsidiary terms, but in each case the concept is related to the main entry. The author has adopted the format of this book to provide the reader a variety of useful applications. These include its use as a dictionary and ready reference guide to the global language of peace and nuclear war; a study guide for introductory courses in Nuclear War and Peace of International Relations, or for any specialized course in the area; a supplement to a textbook or a group of paperback monographs adopted for use in these courses; a source of review material for the political science major enrolled in advanced courses; and a social science aid for use in business, education, government, policy sciences, and journalism

Robust mitotic entry is ensured by a latching switch

Directory of Open Access Journals (Sweden)

Chloe Tuck

2013-07-01

Cell cycle events are driven by Cyclin dependent kinases (CDKs and by their counter-acting phosphatases. Activation of the Cdk1:Cyclin B complex during mitotic entry is controlled by the Wee1/Myt1 inhibitory kinases and by Cdc25 activatory phosphatase, which are themselves regulated by Cdk1:Cyclin B within two positive circuits. Impairing these two feedbacks with chemical inhibitors induces a transient entry into M phase referred to as mitotic collapse. The pathology of mitotic collapse reveals that the positive circuits play a significant role in maintaining the M phase state. To better understand the function of these feedback loops during G2/M transition, we propose a simple model for mitotic entry in mammalian cells including spatial control over Greatwall kinase phosphorylation. After parameter calibration, the model is able to recapture the complex and non-intuitive molecular dynamics reported by Potapova et al. (Potapova et al., 2011. Moreover, it predicts the temporal patterns of other mitotic regulators which have not yet been experimentally tested and suggests a general design principle of cell cycle control: latching switches buffer the cellular stresses which accompany cell cycle processes to ensure that the transitions are smooth and robust.

Robust mitotic entry is ensured by a latching switch.

Science.gov (United States)

Tuck, Chloe; Zhang, Tongli; Potapova, Tamara; Malumbres, Marcos; Novák, Béla

2013-01-01

Cell cycle events are driven by Cyclin dependent kinases (CDKs) and by their counter-acting phosphatases. Activation of the Cdk1:Cyclin B complex during mitotic entry is controlled by the Wee1/Myt1 inhibitory kinases and by Cdc25 activatory phosphatase, which are themselves regulated by Cdk1:Cyclin B within two positive circuits. Impairing these two feedbacks with chemical inhibitors induces a transient entry into M phase referred to as mitotic collapse. The pathology of mitotic collapse reveals that the positive circuits play a significant role in maintaining the M phase state. To better understand the function of these feedback loops during G2/M transition, we propose a simple model for mitotic entry in mammalian cells including spatial control over Greatwall kinase phosphorylation. After parameter calibration, the model is able to recapture the complex and non-intuitive molecular dynamics reported by Potapova et al. (Potapova et al., 2011). Moreover, it predicts the temporal patterns of other mitotic regulators which have not yet been experimentally tested and suggests a general design principle of cell cycle control: latching switches buffer the cellular stresses which accompany cell cycle processes to ensure that the transitions are smooth and robust.

Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors.

Science.gov (United States)

Goto, Tsuyoshi; Kim, Young-Il; Takahashi, Nobuyuki; Kawada, Teruo

2013-01-01

Obesity causes excess fat accumulation in various tissues, most notoriously in the adipose tissue, along with other insulin-responsive organs such as skeletal muscle and the liver, which predisposes an individual to the development of metabolic abnormalities. The molecular mechanisms underlying obesity-induced metabolic abnormalities have not been completely elucidated; however, in recent years, the search for therapies to prevent the development of obesity and obesity-associated metabolic disorders has increased. It is known that several nuclear receptors, when activated by specific ligands, regulate carbohydrate and lipid metabolism at the transcriptional level. The expression of lipid metabolism-related enzymes is directly regulated by the activity of various nuclear receptors via their interaction with specific response elements in promoters of those genes. Many natural compounds act as ligands of nuclear receptors and regulate carbohydrate and lipid metabolism by regulating the activities of these nuclear receptors. In this review, we describe our current knowledge of obesity, the role of lipid-sensing nuclear receptors in energy metabolism, and several examples of food factors that act as agonists or antagonists of nuclear receptors, which may be useful for the management of obesity and the accompanying energy metabolism abnormalities. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

31 CFR 306.23 - Securities eligible to be held in the TREASURY DIRECT Book-entry Securities System.

Science.gov (United States)

2010-07-01

... TREASURY DIRECT Book-entry Securities System. 306.23 Section 306.23 Money and Finance: Treasury Regulations... Securities eligible to be held in the TREASURY DIRECT Book-entry Securities System. (a) Eligible issues. The... conversion to the TREASURY DIRECT Book-entry Securities System. The notice shall specify the period during...

48 CFR 1852.225-8 - Duty-free entry of space articles.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Duty-free entry of space articles. 1852.225-8 Section 1852.225-8 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions...

Regulatory Body Safety Culture in Non-nuclear HROs: Lessons for Nuclear Regulators

International Nuclear Information System (INIS)

Fleming, M.; Bowers, K.

2016-01-01

Regulator safety culture is a relatively new area of investigation, even though deficiencies in regulatory oversight have been identified in a number of public inquiries (e.g., Piper Alpha, Deep Water Horizon). More recently the IAEA report into the Fukushima disaster specifically identified the need for regulatory bodies to have a positive safety culture. While there are clear parallels between duty holder safety culture and regulator safety culture there are also likely to be differences. To date they have been no published studies investigating regulator safety culture. In order to develop a framework to understand regulator safety culture we conducted a literature review and interviewed safety culture subject matter experts from a range of HRO domains (e.g., offshore oil and gas). There was general consensus among participants that regulatory safety culture was an important topic that was worthy of further investigation. That there was general agreement that regulatory safety culture was multi-dimensional and that some of the elements of existing safety culture models applied to regulator culture (e.g., learning and leadership). The participants also identified unique dimensions of regulator safety culture including commitment to high standards and ethics, transparency and perceived role of the regulator. In this paper we will present the results of the interviews and present a model of regulator safety culture. This model will be contrasted with models being used in the nuclear industry. Implications for assessing regulatory safety culture will be discussed. (author)

Slow return of reason to nuclear regulation

International Nuclear Information System (INIS)

McGranery, J.P. Jr.

1983-01-01

During the 1970s, the promise of nuclear power as a cheap source of electricity was seriously eroded in practice. A variety of reasons, including governmental vacillation and delay, have been offered for those circumstances. With a different administration and an apparently improving national economy, it seems appropriate to look at some of the governmental developments of the last year to see if there is hope for the return of reasonable and predictable regulation to nuclear power. This article summarizes some of the principal actions by the courts, the regulatory agency, the administration, and the Congress during that period, as well as pending actions. It concludes that there is a favorable climate and reason to hope, but that success will depend, in the final analysis, upon the conduct of the industry itself. 73 references

Regulations of 19 August 1978 on the optional principles of the Nuclear Safety Committee

International Nuclear Information System (INIS)

1978-01-01

These regulations were published in the Turkish Official Gazette of 19 August 1978 and were made pursuant to Decree no. 7/9141 of 1975 on licensing of nuclear installations which established the Nuclear Safety Committee. They determine the duties and responsibilities of the Committee, its qualifications, its operating principles and its relations with the Nuclear Safety Assistance Service set up in the Turkish Atomic Energy Commission for the purposes of assisting its Secretary General. The regulations also lay down the procedures to be applied for consultations on granting licences. (NEA) [fr

The Establishment of Regulation for Supporting the Development of the First Nuclear Power Plant in Indonesia

International Nuclear Information System (INIS)

Mardha, Amil

2011-01-01

To support construction and operation of the first Nuclear Power Plant (NPP), Government of Indonesia through BAPETEN as a national authority in nuclear energy usage has pushed ahead in enhancing the development of regulatory system. BAPETEN is currently focusing its activities to the development of regulations in the form of Chairman Decree, the development of licensing and inspection system, and manpower for NPP regulators. The process of the establishment of national legislation is based on the Act No.10 Year 2004 on The establishment of legislation. The process of legal drafting to establish or to revise a regulation for controlling of the use of nuclear energy shall comply with the constitutional and institutional requirements of national political and legal system. In drafting the regulation of nuclear safety of NPP, BAPETEN has been involving some other agencies or other related government agencies, and also stakeholders such as utility, academic institutions, and publics. In general, in the process of legal drafting, international publications or other country regulations can be a reference. Present paper deals with the legal basis of regulation, the establishment of legislation in Indonesia, the process in legal drafting regulations of NPP, and the current status of NPP regulations. (author)

31 CFR 357.10 - Laws governing a Treasury book-entry security, TRADES, and security interests or entitlements.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Laws governing a Treasury book-entry... PUBLIC DEBT REGULATIONS GOVERNING BOOK-ENTRY TREASURY BONDS, NOTES AND BILLS HELD IN LEGACY TREASURY DIRECT Treasury/Reserve Automated Debt Entry System (TRADES) § 357.10 Laws governing a Treasury book...

The role of the nuclear safety regulator

International Nuclear Information System (INIS)

Mellado, I.

2007-01-01

The Consejo de Seguridad Nuclear (CSN), or Nuclear Safety Council, is the only Spanish institution qualified in nuclear safety and radiological protection. Created in 1980, the CSN is independent of the Central State Administration, and possesses its own legal standing, estate and resources acquired directly from tax revenues. The CSN proposes regulations and advises the government on subjects within its competence, including the criteria for siting nuclear facilities once the autonomous regions have been informed. The CSN is responsible for issuing mandatory and binding reports to the Ministry of Industry. Tourism and Commerce, and for inspections and evaluation of the facilities included within its realm of competence throughout their phases (construction, start-up, operating and decommissioning). It is also responsible for the radiological control and surveillance of workers, the general public and the environment, as described below. In 1999, a new responsibility was assigned to the CSN to perform studies, assessment and inspections in relation to all phases of radioactive waste and spent fuel management. The CSN reports to the Spanish Parliament and is not subject to the hierarchy or auspices of the Government or the organisations in charge of promoting nuclear energy. The Council itself is an Associative Body comprised of 5 members, appointed by Parliament for a 6 year term (these members cannot be removed). Under this Council is situated an extensive technical body. A General Secretary is seconded by Technical Directors in the area of Nuclear Safety and Radiological Protection. As well there are a R and D Office, an Inspection Office, and a Technical Standards Office. The CSN counts 446 workers, of which 191 are university graduate specialists in nuclear safety or radiological protection. The average age is 45 years. Ongoing training is provided in technical specialties and management. (author)

Improving the regulation of safety at DOE nuclear facilities. Final report

International Nuclear Information System (INIS)

1995-12-01

The report strongly recommends that, with the end of the Cold War, safety and health at DOE facilities should be regulated by outside agencies rather than by DOE itself. The three major recommendations are: under any regulatory scheme, DOE must maintain a strong internal safety management system; essentially all aspects of safety at DOE's nuclear facilities should be externally regulated; and existing agencies rather than a new one should be responsible for external regulation

1990 No. 1918. The Nuclear Installations Act 1965 (Repeal and Modifications) Regulations 1990

International Nuclear Information System (INIS)

1990-01-01

These Regulations entered into force on 31 October 1990. They repeal part of Section (1) of the Nuclear Installations Act 1965 to remove the exemption of the United Kingdom Atomic Energy Authority (UKAEA) from licensing under the Act. The Regulations also amend the 1965 Act to ensure that the UKAEA's duties in respect of the safety of premises it occupies will continue to apply whether or not a nuclear site licence has been granted. (NEA) [fr

Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction.

Science.gov (United States)

Poleshko, Andrey; Shah, Parisha P; Gupta, Mudit; Babu, Apoorva; Morley, Michael P; Manderfield, Lauren J; Ifkovits, Jamie L; Calderon, Damelys; Aghajanian, Haig; Sierra-Pagán, Javier E; Sun, Zheng; Wang, Qiaohong; Li, Li; Dubois, Nicole C; Morrisey, Edward E; Lazar, Mitchell A; Smith, Cheryl L; Epstein, Jonathan A; Jain, Rajan

2017-10-19

Progenitor cells differentiate into specialized cell types through coordinated expression of lineage-specific genes and modification of complex chromatin configurations. We demonstrate that a histone deacetylase (Hdac3) organizes heterochromatin at the nuclear lamina during cardiac progenitor lineage restriction. Specification of cardiomyocytes is associated with reorganization of peripheral heterochromatin, and independent of deacetylase activity, Hdac3 tethers peripheral heterochromatin containing lineage-relevant genes to the nuclear lamina. Deletion of Hdac3 in cardiac progenitor cells releases genomic regions from the nuclear periphery, leading to precocious cardiac gene expression and differentiation into cardiomyocytes; in contrast, restricting Hdac3 to the nuclear periphery rescues myogenesis in progenitors otherwise lacking Hdac3. Our results suggest that availability of genomic regions for activation by lineage-specific factors is regulated in part through dynamic chromatin-nuclear lamina interactions and that competence of a progenitor cell to respond to differentiation signals may depend upon coordinated movement of responding gene loci away from the nuclear periphery. Copyright © 2017 Elsevier Inc. All rights reserved.

Education and training requirements of nuclear power plant personnel

International Nuclear Information System (INIS)

Donato, R.; Perlas, C.A.; Conti, E.

1978-01-01

This bibliography was compiled by the Scientific Library staff to help in the intensified training program being undertaken by the Philippine Atomic Energy Commission (PAEC) for the nuclear power plant personnel of the Philippines' first nuclear power reactor. This bibliography covers the period 1955 - 1976 of the Nuclear Science Abstracts and is composed of 281 entries. Arrangement of these entries is by broad subject category

Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export.

Science.gov (United States)

Behrens, Ryan T; Aligeti, Mounavya; Pocock, Ginger M; Higgins, Christina A; Sherer, Nathan M

2017-02-01

HIV-1's Rev protein forms a homo-oligomeric adaptor complex linking viral RNAs to the cellular CRM1/Ran-GTP nuclear export machinery through the activity of Rev's prototypical leucine-rich nuclear export signal (NES). In this study, we used a functional fluorescently tagged Rev fusion protein as a platform to study the effects of modulating Rev NES identity, number, position, or strength on Rev subcellular trafficking, viral RNA nuclear export, and infectious virion production. We found that Rev activity was remarkably tolerant of diverse NES sequences, including supraphysiological NES (SNES) peptides that otherwise arrest CRM1 transport complexes at nuclear pores. Rev's ability to tolerate a SNES was both position and multimerization dependent, an observation consistent with a model wherein Rev self-association acts to transiently mask the NES peptide(s), thereby biasing Rev's trafficking into the nucleus. Combined imaging and functional assays also indicated that NES masking underpins Rev's well-known tendency to accumulate at the nucleolus, as well as Rev's capacity to activate optimal levels of late viral gene expression. We propose that Rev multimerization and NES masking regulates Rev's trafficking to and retention within the nucleus even prior to RNA binding. HIV-1 infects more than 34 million people worldwide causing >1 million deaths per year. Infectious virion production is activated by the essential viral Rev protein that mediates nuclear export of intron-bearing late-stage viral mRNAs. Rev's shuttling into and out of the nucleus is regulated by the antagonistic activities of both a peptide-encoded N-terminal nuclear localization signal and C-terminal nuclear export signal (NES). How Rev and related viral proteins balance strong import and export activities in order to achieve optimal levels of viral gene expression is incompletely understood. We provide evidence that multimerization provides a mechanism by which Rev transiently masks its NES peptide

Regulations concerning the fabricating business of nuclear fuel materials

International Nuclear Information System (INIS)

1979-01-01

The regulations are entirely revised under the law for the regulations of nuclear materials, nuclear fuel materials and reactors and provisions concerning the fabricating business in the order for execution of the law. Basic concepts and terms are defined, such as: exposure dose; accumulative dose; controlled area; inspected surrounding area; employee and radioactive waste. The application for permission of the fabricating business shall include: location of processing facilities; structure of building structure and equipment of chemical processing facilities; molding facilities; structure and equipment of covering and assembling facilities, storage facilities of nuclear fuel materials and disposal facilities of radioactive waste, etc. Records shall be made and kept for particular periods in each works and place of enterprise on inspection of processing facilities, control of dose, operation, maintenance, accident of processing facilities and weather. Specified measures shall be taken in controlled area and inspected surrounding area to restrict entrance. Measures shall be made not to exceed permissible exposure dose for employees defined by the Director General of Science and Technology Agency. Inspection and check up of processing facilities shall be carried on by employees more than once a day. Operation of processing facilities, transportation in the works and enterprise, storage, disposal, safety securing, report and measures in dangerous situations, etc. are in detail prescribed. (Okada, K.)

Toward introduction of risk informed safety regulation. Nuclear Safety Commission taskforce's interim report

International Nuclear Information System (INIS)

2006-01-01

Nuclear Safety Commission's taskforce on 'Introduction of Safety Regulation Utilizing Risk Information' completed the interim report on its future subjects and directions in December 2005. Although current safety regulatory activities have been based on deterministic approach, this report shows the risk informed approach is expected to be very useful for making nuclear safety regulation and assurance activities reasonable and also for appropriate allocation of regulatory resources. For introduction of risk informed regulation, it also recommends pileups of experiences with gradual introduction and trial of the risk informed approach, improvement of plant maintenance rules and regulatory requirements utilizing risk information, and establishment of framework to assure quality of risk evaluation. (T. Tanaka)

Experimental nuclear thermoelectric assembly open-quotes Gammaclose quotes-a prototype of an unattended self-regulating nuclear thermoelectric station

International Nuclear Information System (INIS)

Buinitskii, B.A.; Kaplar, E.P.; Kondrat'ev, F.V.; Leppik, P.A.; Nafikov, D.Ya.; Pavelko, V.I.; Rychev, A.S.; Tarasov, V.P.; Khlopkin, N.S.

1993-01-01

At the beginning of the seventies, the concept of building small atomic power stations with direct conversion of the thermal energy of a reactor for supplying electricity and heat to consumers located at remote and inaccessible regions was developed on the basis of assessment calculations and technical studies made in the I.V. Kurchatov Institute of Atomic Energy. When new technical solutions were adopted to put this concept into practice, combined trials on a test stand were required. For this purpose, the nuclear thermoelectric test-demonstration assembly open-quotes Gammaclose quotes was built and put into operation in 1981. It is based on the three principles which determine the development of unattended self-regulating nuclear thermoelectric stations: using a water-water reactor with self-regulation of the power as a source of heat; using a cooling system without pumps but with natural circulation of the coolant in the primary and intermediate circuits for removing the hend thermoelectric conversion of heat into electricity. During the ten years of operation of the open-quotes Gammaclose quotes assembly, a research program on the principles of unattended self-regulating nuclear thermoelectric stations was carried out and the results are summarized

The Role of the Regulator in the Field of Safety Culture to Shun Nuclear Accident

International Nuclear Information System (INIS)

Kandil, M.M.

2016-01-01

The 2011 accident at the Fukushima Daiichi nuclear power plant in Japan has, as might be expected, led to improvements in equipment at plants around the world that have fortified safety systems and allowed for better protection against rare, extreme natural events. Equally important to the process of improving nuclear safety is the emphasis placed on implementing quality improvements to the human side of nuclear safety, a crucial element that is often not considered by those outside the nuclear sector. Ensuring nuclear reactor safety is not only a question of physical protection against all credible threats, enhancing robustness of important safety systems and increasing redundancy of back-up power and water cooling systems, but also one of making certain that qualified and trained staff are supported by effective procedures. However, these assets are valued only in an organizational culture that places a premium on ensuring high levels of safety, or implementing what is called an effective “nuclear safety culture”. Principles, characteristics and factors for effective safety culture are to great extent similar between licencees and regulatory bodies and can be applied for developing RB’s safety. Safety is the primary purpose of the regulatory body, Regulator plays a significant role in the field of nuclear safety even though the prime responsibility for safety belongs to the operator, and it is the regulator which actually decides what is considered to be safe. In order to effectively implement the international principle of high level of nuclear safety, nuclear safety culture should be clearly named as an objective in international nuclear legal acts and the regulator’s responsibility for promotion of nuclear safety culture should be established. What is more difficult for the regulator is finding the right balance of firmness but fairness in dealing with the operator. In addition to enforcing safety regulations, the regulator should have a positive

Order for execution of the law concerning regulations of nuclear source materials, nuclear fuel materials and reactors

International Nuclear Information System (INIS)

1985-01-01

This ordinance is stipulated under the law concerning the regulation of nuclear raw materials, nuclear fuel materials and reactors. The designation for refining and processing businesses under the law shall be obtained for each works or enterprise where these operations are to be practiced. Persons who intend to accept the designation shall file applications attaching business plans and the other documents specified by the ordinances of the Prime Minister's Office and other ministry orders. The permission for the installation of nuclear reactors under the law shall be received for each works or enterprise where reactors are to be set up. Persons who intend to get the permission shall file applications attaching the financing plans required for the installation of reactors and the other documents designated by the orders of the competent ministry. The permission concerning the reactors installed on foreign ships shall be obtained for each ship which is going to enter into the Japanese waters. Persons who ask for the permission shall file applications attaching the documents which explain the safety of reactor facilities and the other documents defined by the orders of the Ministry of Transportation. The designation for reprocessing business and the application for it are provided for, respectively. The usage of nuclear fuel materials, nuclear raw materials and internationally regulated goods is ruled in detail. (Kubozone, M.)

Order for execution of the law concerning regulations of nuclear source materials, nuclear fuel materials and reactors

International Nuclear Information System (INIS)

1981-01-01

This ordinance is stipulated under the law concerning the regulation of nuclear raw materials, nuclear fuel materials and reactors. The designation for refining and processing businesses under the law shall be obtained for each works or enterprise where these operations are to be practiced. Persons who intend to accept the designation shall file applications attaching business plans and the other documents specified by the ordinances of the Prime Minister's Office and other ministry orders. The permission for the installation of nuclear reactors under the law shall be received for each works or enterprise where reactors are to be set up. Persons who intend to get the permission shall file applications attaching the financing plans required for the installation of reactors and the other documents designated by the orders of the competent ministry. The permission concerning the reactors installed on foreign ships shall be obtained for each ship which is going to enter into the Japanese waters. Persons who ask for the permission shall file applications attaching the documents which explain the safety of reactor facilities and the other documents defined by the orders of the Ministry of Transportation. The designation for reprocessing business and the application for it are provided for, respectively. The usage of nuclear fuel materials, nuclear raw materials and internationally regulated goods is ruled in detail.(Okada, K.)

Probabilistic risk assessment in nuclear power plant regulation

Energy Technology Data Exchange (ETDEWEB)

Wall, J B

1980-09-01

A specific program is recommended to utilize more effectively probabilistic risk assessment in nuclear power plant regulation. It is based upon the engineering insights from the Reactor Safety Study (WASH-1400) and some follow-on risk assessment research by USNRC. The Three Mile Island accident is briefly discussed from a risk viewpoint to illustrate a weakness in current practice. The development of a probabilistic safety goal is recommended with some suggestions on underlying principles. Some ongoing work on risk perception and the draft probabilistic safety goal being reviewed on Canada is described. Some suggestions are offered on further risk assessment research. Finally, some recent U.S. Nuclear Regulatory Commission actions are described.

The cell surface expressed nucleolin is a glycoprotein that triggers calcium entry into mammalian cells

International Nuclear Information System (INIS)

Losfeld, Marie-Estelle; Khoury, Diala El; Mariot, Pascal; Carpentier, Mathieu; Krust, Bernard; Briand, Jean-Paul; Mazurier, Joel; Hovanessian, Ara G.; Legrand, Dominique

2009-01-01

Nucleolin is an ubiquitous nucleolar phosphoprotein involved in fundamental aspects of transcription regulation, cell proliferation and growth. It has also been described as a shuttling molecule between nucleus, cytosol and the cell surface. Several studies have demonstrated that surface nucleolin serves as a receptor for various extracellular ligands implicated in cell proliferation, differentiation, adhesion, mitogenesis and angiogenesis. Previously, we reported that nucleolin in the extranuclear cell compartment is a glycoprotein containing N- and O-glycans. In the present study, we show that glycosylation is an essential requirement for surface nucleolin expression, since it is prevented when cells are cultured in the presence of tunicamycin, an inhibitor of N-glycosylation. Accordingly, surface but not nuclear nucleolin is radioactively labeled upon metabolic labeling of cells with [ 3 H]glucosamine. Besides its well-demonstrated role in the internalization of specific ligands, here we show that ligand binding to surface nucleolin could also induce Ca 2+ entry into cells. Indeed, by flow cytometry, microscopy and patch-clamp experiments, we show that the HB-19 pseudopeptide, which binds specifically surface nucleolin, triggers rapid and intense membrane Ca 2+ fluxes in various types of cells. The use of several drugs then indicated that Store-Operated Ca 2+ Entry (SOCE)-like channels are involved in the generation of these fluxes. Taken together, our findings suggest that binding of an extracellular ligand to surface nucleolin could be involved in the activation of signaling pathways by promoting Ca 2+ entry into cells

Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors

Directory of Open Access Journals (Sweden)

Jasmine Kolb

2018-04-01

Full Text Available Summary: Adult neurogenesis is regulated by stem cell niche-derived extrinsic factors and cell-intrinsic regulators, yet the mechanisms by which niche signals impinge on the activity of intrinsic neurogenic transcription factors remain poorly defined. Here, we report that MEIS2, an essential regulator of adult SVZ neurogenesis, is subject to posttranslational regulation in the SVZ olfactory bulb neurogenic system. Nuclear accumulation of MEIS2 in adult SVZ-derived progenitor cells follows downregulation of EGFR signaling and is modulated by methylation of MEIS2 on a conserved arginine, which lies in close proximity to nested binding sites for the nuclear export receptor CRM1 and the MEIS dimerization partner PBX1. Methylation impairs interaction with CRM1 without affecting PBX1 dimerization and thereby allows MEIS2 nuclear accumulation, a prerequisite for neuronal differentiation. Our results describe a form of posttranscriptional modulation of adult SVZ neurogenesis whereby an extrinsic signal fine-tunes neurogenesis through posttranslational modification of a transcriptional regulator of cell fate. : A hallmark of adult neurogenesis is its strong dependence on physiological stimuli and environmental signals. Schulte and colleagues show that the nuclear localization and activity of a transcriptional regulator of adult neurogenesis is controlled by posttranslational modification. Their results link intrinsic control over neuron production to external signals and help to explain how adult neurogenesis can occur “on demand.” Keywords: subventricular zone, stem cell niche, posttranslational modification, controlled nuclear import, TALE-homdomain protein, MEIS2, PBX1, CRM1, neurogenesis, stem cell niche

Statutory Instrument No. 2056, The Nuclear Installations Act 1965 etc. (Repeals and Modifications) Regulations 1974

International Nuclear Information System (INIS)

1975-01-01

These Regulations contain repeals and modifications of provisions of the Nuclear Installations Act 1965 and a modification of the Nuclear Installations (Dangerous Occurrences) Regulations 1965. They are made in consequence of the establishment on 1st January 1975 of the Health and Safety Executive and the coming into operation on that date of provisions of the Health and Safety at Work etc. Act 1974 which supersede or affect provisions of the 1965 Act and the 1965 Regulations. (NEA) [fr

The regulation of radioactive effluent release in France (mainly from large nuclear installations)

International Nuclear Information System (INIS)

Hebert, Jean.

1978-01-01

In parallel with the licensing system for construction and operation of classified or so-called large nuclear installations (INB) there are in France regulations for the release of radioactive effuents from such installations. The regulations applicable to installations other than INBs are not specifically of a nuclear nature, while those covering INBs, which are analysed in this study, in particular, cover effluent release in liquid or gaseous form. The licensing and control procedures for such release are analysed in detail. (NEA) [fr

31 CFR 363.101 - Can an account owner transfer a book-entry savings bond to a minor?

Science.gov (United States)

2010-07-01

... REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT Book-Entry Savings Bonds Purchased Through TreasuryDirect Gifts § 363.101 Can an account owner transfer a book-entry savings bond to a minor? An account owner can transfer a book-entry savings bond held in TreasuryDirect ® to a minor as a gift or pursuant...

Linear quadratic regulator design for an unpowered, winged re-entry vehicle

NARCIS (Netherlands)

Mooij, E.

1998-01-01

This report describes the design of an attitude controller for an unpowered, winged re-entry vehicle. The decoupling of the symmetric and asymmetric motion makes it possible to design two separate controllers, one for the pitch mot ion and one for the lateral motion. The design of the controller, a

Spatiotemporal Regulation of Nuclear Transport Machinery and Microtubule Organization

Science.gov (United States)

Okada, Naoyuki; Sato, Masamitsu

2015-01-01

Spindle microtubules capture and segregate chromosomes and, therefore, their assembly is an essential event in mitosis. To carry out their mission, many key players for microtubule formation need to be strictly orchestrated. Particularly, proteins that assemble the spindle need to be translocated at appropriate sites during mitosis. A small GTPase (hydrolase enzyme of guanosine triphosphate), Ran, controls this translocation. Ran plays many roles in many cellular events: nucleocytoplasmic shuttling through the nuclear envelope, assembly of the mitotic spindle, and reorganization of the nuclear envelope at the mitotic exit. Although these events are seemingly distinct, recent studies demonstrate that the mechanisms underlying these phenomena are substantially the same as explained by molecular interplay of the master regulator Ran, the transport factor importin, and its cargo proteins. Our review focuses on how the transport machinery regulates mitotic progression of cells. We summarize translocation mechanisms governed by Ran and its regulatory proteins, and particularly focus on Ran-GTP targets in fission yeast that promote spindle formation. We also discuss the coordination of the spatial and temporal regulation of proteins from the viewpoint of transport machinery. We propose that the transport machinery is an essential key that couples the spatial and temporal events in cells. PMID:26308057

Domestic Regulation for Periodic Safety Review of Nuclear Power Plants

International Nuclear Information System (INIS)

Kim, Daesik; Ahn, Seunghoon; Auh, Geunsun; Lee, Jonghyeok

2015-01-01

The so-called Periodic Safety Review (PSR) has been carried out such safety assessment throughout its life, on a periodic basis. In January 2001, the Atomic Energy Act and related regulations were amended to adopt the PSR institutional scheme from IAEA Nuclear Safety Guide 50-SG-O12. At that time the safety assessment was made to review the plant safety on 10 safety factors, such as aging management and emergency planning, where the safety factor indicates the important aspects of safety of an operating NPP to be addressed in the PSR. According to this legislation, the domestic utility, the KHNP has conducted the PSR for the operating NPP of 10 years coming up from operating license date, starting since May 2000. Some revisions in the PSR rule were made to include the additional safety factors last year. This paper introduces the current status of the PSR review and regulation, in particular new safety factors and updated technical regulation. Comprehensive safety assessment for Korea Nuclear Power Plants have performed a reflecting design and procedure changes and considering the latest technology every 10 years. This paper also examined the PSR system changes in Korea. As of July 2015, reviews for PSR of 18 units have been completed, with 229 nuclear safety improvement items. And implementation have been completed for 165 of them. PSR system has been confirmed that it has contributed to improvement of plant safety. In addition, this paper examined the PSR system change in Korea

Improving the regulation of safety at DOE nuclear facilities. Final report: Appendices

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-12-01

The report strongly recommends that, with the end of the Cold War, safety and health at DOE facilities should be regulated by outside agencies rather than by any regulatory scheme, DOE must maintain a strong internal safety management system; essentially all aspects of safety at DOE`s nuclear facilities should be externally regulated; and existing agencies rather than a new one should be responsible for external regulation.

Improving the regulation of safety at DOE nuclear facilities. Final report: Appendices

International Nuclear Information System (INIS)

1995-12-01

The report strongly recommends that, with the end of the Cold War, safety and health at DOE facilities should be regulated by outside agencies rather than by any regulatory scheme, DOE must maintain a strong internal safety management system; essentially all aspects of safety at DOE's nuclear facilities should be externally regulated; and existing agencies rather than a new one should be responsible for external regulation

Cost-benefit comparison of nuclear and nonnuclear health and safety protective measures and regulations

International Nuclear Information System (INIS)

O'Donnell, E.P.; Mauro, J.J.

1979-01-01

This article compares the costs and benefits of health and safety measures and regulations in the nuclear and nonnuclear fields. A cost-benefit methodology for nuclear safety concerns is presented and applied to existing nuclear plant engineered safety features. Comparisons in terms of investment costs to achieve reductions in mortality rates are then made between nuclear plant safety features and the protective measures and regulations associated with nonnuclear risks, particularly with coal-fired power plants. These comparisons reveal a marked inconsistency in the cost effectiveness of health and safety policy, in which nuclear regulatory policy requires much greater investments to reduce the risk of public mortality than is required in nonnuclear areas where reductions in mortality rates could be achieved at much lower cost. A specific example of regulatory disparity regarding gaseous effluent limits for nuclear and fossil-fuel power plants is presented. It is concluded that a consistent health and safety regulatory policy based on uniform risk and cost-benefit criteria should be adopted and that future proposed Nuclear Regulatory Commission regulatory requirements should be critically evaluated from a cost-benefit viewpoint

Regulation of the life cycle of nuclear installations. Peer discussions on regulatory practices

International Nuclear Information System (INIS)

1999-06-01

This report arises from the sixth series of peer discussions on regulatory practices entitled 'Regulation of Life Cycle of Nuclear Installations'. Senior regulators from 18 Member States participated in three peer group discussions during 1997-1998. This report presents the outcome of these meetings and recommendations of good practices identified by senior regulators, which do not necessarily reflect those of the governments of the nominating Member States, the nominating organizations, or the IAEA. The purpose of this report is to disseminate the views which the senior regulators presented at the meetings relating to the policies, principles and requirements imposed by regulatory bodies for the safe management of the life cycle of a nuclear installation. The intention of doing this is to assist Member States in the formulation and enhancement of their regulatory control over PLCM by identifying commonly accepted good practices. This report is structured to cover the subject matter under the following main headings: Policies and Principles for the Life Cycle Management of Nuclear Installations; Responsibilities of the Regulatory Body and the Operating Organization; Requirements and Criteria Imposed by the Regulatory Body; Licensing and Regulatory Assessment for Plant Life Cycle Management; and Good Practices

Nuclear regulator practices for communicating with the public

International Nuclear Information System (INIS)

Hayden, E.

2007-01-01

For decades, the U.S. Nuclear Regulatory Commission has communicated with members of the public so that they are aware of what the NRC does to protect them from the hazards of unnecessary radiation from nuclear power plants and other uses of radioactive material. Because the agency views nuclear regulation as the public's business, it should be transacted openly and candidly in order to maintain the public's confidence. The NRC recognizes that the public must be informed about, and have a reasonable opportunity to participate meaningfully in, the Agency's regulatory processes. The agency uses a variety of means to ensure openness in its regulatory process and thereby increasing public confidence. With rapidly expanding electronic capability, the agency has looked to new ways to reach out to the American public to let them know we are on the job overseeing nuclear safety. While we continue to communicate in some of the traditional ways - news releases, news conferences, briefing, speeches, Internet, brochures, and meetings - we are also exploring using blogs, mobile cell phone notifications, focus groups, open houses, and e-mail alerts to name a few. (author)

Interaction of KSHV with Host Cell Surface Receptors and Cell Entry

Directory of Open Access Journals (Sweden)

Mohanan Valiya Veettil

2014-10-01

Full Text Available Virus entry is a complex process characterized by a sequence of events. Since the discovery of KSHV in 1994, tremendous progress has been made in our understanding of KSHV entry into its in vitro target cells. KSHV entry is a complex multistep process involving viral envelope glycoproteins and several cell surface molecules that is utilized by KSHV for its attachment and entry. KSHV has a broad cell tropism and the attachment and receptor engagement on target cells have an important role in determining the cell type-specific mode of entry. KSHV utilizes heparan sulfate, integrins and EphrinA2 molecules as receptors which results in the activation of host cell pre-existing signal pathways that facilitate the subsequent cascade of events resulting in the rapid entry of virus particles, trafficking towards the nucleus followed by viral and host gene expression. KSHV enters human fibroblast cells by dynamin dependant clathrin mediated endocytosis and by dynamin independent macropinocytosis in dermal endothelial cells. Once internalized into endosomes, fusion of the viral envelope with the endosomal membranes in an acidification dependent manner results in the release of capsids which subsequently reaches the nuclear pore vicinity leading to the delivery of viral DNA into the nucleus. In this review, we discuss the principal mechanisms that enable KSHV to interact with the host cell surface receptors as well as the mechanisms that are required to modulate cell signaling machinery for a successful entry.

Regulation and inspection support radiation protection in nuclear and other installations

International Nuclear Information System (INIS)

Williams, M.K.; Potter, C.; Harbison, S.A.

1996-01-01

Over the past fifty years, radiation protection legislation in the UK has developed from a narrow industry-specific base to a comprehensive package of regulations and supporting Approved Code of Practice, with additional provisions for nuclear installations. Development of this legislation mirrors progress in international understanding about the risks from exposure to ionising radiation. The current Ionising Radiations Regulations 1985 largely implement the Euratom 1980 Basic Safety Standards Directive and place particular emphasis on the need to keep exposure as low as reasonably practicable. The regulations have been underpinned by the development of the concept of the Tolerability of Risk and the application of the ALARP/ALARA principle, particularly at nuclear installations. Analysis of dose data on HSE's Central Index of Dose Information has shown the general success of this approach in the UK; the data have also allowed targeting of inspection effort. Currently, the Health and Safety Commission and Executive are developing plans for implementing the revised EU Basic Safety Standards Directive. (author)

Regulations by the DFTCE concerning the Fund for the decommissioning of nuclear installations

International Nuclear Information System (INIS)

1985-02-01

These Regulations were made by the Federal Ministry of Transport, Communications and Energy in implementation of the Ordinance of 5 December 1983 establishing a fund for the decommissioning of nuclear installations. They specify the way in which nuclear operators must contribute to the fund and the method for calculating the contributions. The costs of decommissioning also include dismantling and disposal of the resulting waste. The Regulations entered into force retroactively, on 1 January 1984, on the same date as the 1983 Ordinance. (NEA) [fr

7 CFR 319.8-26 - Material refused entry.

Science.gov (United States)

2010-01-01

... Plant Protection Act (7 U.S.C. 7714 and 7731). Neither the Department of Agriculture nor the inspector... 7 Agriculture 5 2010-01-01 2010-01-01 false Material refused entry. 319.8-26 Section 319.8-26 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION...

Nuclear power plant personnel entry level qualifications and training

International Nuclear Information System (INIS)

Jorgensen, C.C.; Haas, P.M.; Selby, D.L.; Lowry, J.C.

1983-01-01

This paper summarizes the early results and current status of a research program at ORNL which is intended to provide the methods and technical basis for NRC to initiate the use of the Systems Approach to Training (SAT) in the evaluation of training programs and entry level qualifications for NPP control room personnel. The program is an outgrowth of previous studies of simulator hardware and simulator training requirements under the Safety Related Operator Actions Program which recommended adaptation of a systems methodology to development and evaluation of NPP training programs

The Swedish Radiation Protection Institute's regulations concerning the final management of spent nuclear fuel and nuclear waste - with background and comments

International Nuclear Information System (INIS)

2000-11-01

This report presents and comments on the Swedish Radiation Protection Institute's Regulations concerning the Protection of Human Health and the Environment in connection with the Final Management of Spent Nuclear Fuel or Nuclear Waste, SSI FS 1998: 1

Some internationl law elements of national nuclear regulations from the Polish point of view

International Nuclear Information System (INIS)

Gadkowski, T.

1992-01-01

The essential contents of the Polish Nuclear Act from 1986 reflects on one hand needs and possibilities of the industrial use of nuclear energy and, on the other, international obligations of Poland. Poland is a State with a limited activity regarding to industrial use of nuclear energy; the main international-law elements of national nuclear regulations can be described as follows: 1. The good-neighborliness principle concerning the siting of nuclear installations in border areas. 2. An adequate concept of nuclear damage. 3. An adequate concept of liability for nuclear damage. (orig./HSCH)

The nuclear safety regulation in Japan and the response to changes of circumstances surrounding the nuclear electricity generation

International Nuclear Information System (INIS)

Hombu, K.; Hirota, M.; Taniguchi, T.; Tanaka, N.; Akimoto, S.

2001-01-01

The influences of external factors on nuclear safety are discussed in this paper, based on the views on the circumstances of nuclear electricity generation. The following external factors, which might have some potential impacts on nuclear safety, are selected for discussion: (1) The deregulation in the electricity generation industry; (2) The modification of approval/certification system in the regulation of electricity generation; (3) The influences on social atmosphere due to the occurrence of a series of troubles; (4) The government reform and the structural adjustment of industry and (5) Others. Our further discussion seems to focus on the following 2 issues: (a) Whether nuclear power and the other electrical sources should compete with each other for short term economical cost, or whether factors of cost stability and competitiveness as well as longer term energy supply security and global environmental issues ranging over several decades should be considered; (b) How to realize the appropriate regulation from the perspective of public acceptance and confidence (when a series of troubles occur) without imposing unnecessary burdens on industry and without jeopardizing safety. These issues may be common among many countries and can be widely discussed. (author)

Governmental organization for the regulation of nuclear power plants. A code of practice

International Nuclear Information System (INIS)

1978-01-01

This Code of Practice recommends requirements for a regulatory body responsible for regulating the siting, construction, commissioning, operation and decommissioning of nuclear power plants for safety. It forms part of the Agency's programme, referred to as the NUSS programme, for establishing Codes of Practice and Safety Guides relating to land-based stationary thermal neutron power plants. This Code has been prepared to provide recommendations for Member States embarking on a nuclear power programme and covers: (1) Establishing and maintaining a regulatory body to which is assigned the responsibility for authorizing the siting, construction, commissioning, operation and decommissioning of nuclear power plants after appropriate review and assessment (2) Organizing for and conducting the review and assessment of the safety of nuclear power plants (3) Conducting the necessary regulatory inspections and taking necessary enforcement actions during all stages of the licensing process in order to ensure that the limits and conditions of the licences are being complied with by the applicants/licensees and their contractors (4) Establishing regulations and criteria for nuclear-related health, safety and environmental protection

The legal regime governing the peaceful uses of nuclear energy. II. International Regulations. Pt.1. Regulations on peaceful uses

International Nuclear Information System (INIS)

1979-12-01

The first volume on atomic energy law published by CNEN reproduced national laws and regulations in that field. This book constitutes part one of the second volume and deals with international nuclear conventions and cooperation as at 30 June 1978. It reproduces the instruments and conventions which set up the international nuclear agencies, recommendations in the field of radiation protection and nuclear safety, the nuclear third party liability conventions, the international instruments concerning technical and scientific cooperation and finally, the bilateral cooperation agreements between Italy and other nations and its agreements with international organizations (NEA) [fr

Nuclear translocation contributes to regulation of DNA excision repair activities

DEFF Research Database (Denmark)

Knudsen, Nina Østergaard; Andersen, Sofie Dabros; Lützen, Anne

2009-01-01

for regulation of nuclear import that is necessary for proper localization of the repair proteins. This review summarizes the current knowledge on nuclear import mechanisms of DNA excision repair proteins and provides a model that categorizes the import by different mechanisms, including classical nuclear import......DNA mutations are circumvented by dedicated specialized excision repair systems, such as the base excision repair (BER), nucleotide excision repair (NER), and mismatch repair (MMR) pathways. Although the individual repair pathways have distinct roles in suppressing changes in the nuclear DNA......, it is evident that proteins from the different DNA repair pathways interact [Y. Wang, D. Cortez, P. Yazdi, N. Neff, S.J. Elledge, J. Qin, BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures, Genes Dev. 14 (2000) 927-939; M. Christmann, M...

Different regulatory strategies in regulation of nuclear power projects: An Indian experience

International Nuclear Information System (INIS)

Khan, Sohail Ahmad

2002-01-01

Regulatory strategy needed for management of safety and safety culture involves careful planning and use of engineering concepts keeping in mind feasibility to implement certain safety requirements. It also requires adequate attention on working environment and mental conditions of designers, operating and maintenance staff and regulators. Different strategies followed during safety review and regulatory inspection of nuclear power projects for improving status of safety management and safety cultures have given certain results. The present paper brings out certain experience gained during regulation of Indian Nuclear Power Projects by Atomic Energy Regulatory Board of India in the area of management of safety and safety culture. (author)

Regulatory control, nuclear safety regulation and waste management in Spain

International Nuclear Information System (INIS)

Martin, A.

2000-01-01

This article presents the challenges that faces the spanish regulatory authority. The deregulation of electricity industry imposes severe changes in nuclear power economics and forces nuclear power to compete with other sources of electricity. A pressure is perceived for regulatory effectiveness primarily since the cost of regulation is a component of the cost of the product. This effectiveness gain in regulatory control will be reached through systematic strategic analysis, formulation and implementation. The regulatory aspects of plant life extension and of waste management are examined

Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID.

Directory of Open Access Journals (Sweden)

Quy Le

2015-09-01

Full Text Available AID (Activation Induced Deaminase deaminates cytosines in DNA to initiate immunoglobulin gene diversification and to reprogram CpG methylation in early development. AID is potentially highly mutagenic, and it causes genomic instability evident as translocations in B cell malignancies. Here we show that AID is cell cycle regulated. By high content screening microscopy, we demonstrate that AID undergoes nuclear degradation more slowly in G1 phase than in S or G2-M phase, and that mutations that affect regulatory phosphorylation or catalytic activity can alter AID stability and abundance. We directly test the role of cell cycle regulation by fusing AID to tags that destabilize nuclear protein outside of G1 or S-G2/M phases. We show that enforced nuclear localization of AID in G1 phase accelerates somatic hypermutation and class switch recombination, and is well-tolerated; while nuclear AID compromises viability in S-G2/M phase cells. We identify AID derivatives that accelerate somatic hypermutation with minimal impact on viability, which will be useful tools for engineering genes and proteins by iterative mutagenesis and selection. Our results further suggest that use of cell cycle tags to regulate nuclear stability may be generally applicable to studying DNA repair and to engineering the genome.

PHITS code improvements by Regulatory Standard and Research Department Secretariat of Nuclear Regulation Authority

International Nuclear Information System (INIS)

Goko, Shinji

2017-01-01

As for the safety analysis to be carried out when a nuclear power company applies for installation permission of facility or equipment, business license, design approval etc., the Regulatory Standard and Research Department Secretariat of Nuclear Regulation Authority continuously conducts safety research for the introduction of various technologies and their improvement in order to evaluate the adequacy of this safety analysis. In the field of the shielding analysis of nuclear fuel transportation materials, this group improved the code to make PHITS applicable to this field, and has been promoting the improvement as a tool used for regulations since FY2013. This paper introduced the history and progress of this safety research. PHITS 2.88, which is the latest version as of November 2016, was equipped with the automatic generation function of variance reduction parameters [T-WWG] etc., and developed as the tool equipped with many effective functions in practical application to nuclear power regulations. In addition, this group conducted the verification analysis against nuclear fuel packages, which showed a good agreement with the analysis by MCNP, which is extensively used worldwide and abundant in actual results. It also shows a relatively good agreement with the measured values, when considering differences in analysis and measurement. (A.O.)

Arginine Methylation Regulates MEIS2 Nuclear Localization to Promote Neuronal Differentiation of Adult SVZ Progenitors.

Science.gov (United States)

Kolb, Jasmine; Anders-Maurer, Marie; Müller, Tanja; Hau, Ann-Christin; Grebbin, Britta Moyo; Kallenborn-Gerhardt, Wiebke; Behrends, Christian; Schulte, Dorothea

2018-04-10

Adult neurogenesis is regulated by stem cell niche-derived extrinsic factors and cell-intrinsic regulators, yet the mechanisms by which niche signals impinge on the activity of intrinsic neurogenic transcription factors remain poorly defined. Here, we report that MEIS2, an essential regulator of adult SVZ neurogenesis, is subject to posttranslational regulation in the SVZ olfactory bulb neurogenic system. Nuclear accumulation of MEIS2 in adult SVZ-derived progenitor cells follows downregulation of EGFR signaling and is modulated by methylation of MEIS2 on a conserved arginine, which lies in close proximity to nested binding sites for the nuclear export receptor CRM1 and the MEIS dimerization partner PBX1. Methylation impairs interaction with CRM1 without affecting PBX1 dimerization and thereby allows MEIS2 nuclear accumulation, a prerequisite for neuronal differentiation. Our results describe a form of posttranscriptional modulation of adult SVZ neurogenesis whereby an extrinsic signal fine-tunes neurogenesis through posttranslational modification of a transcriptional regulator of cell fate. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Influence on UK Nuclear Regulation from the Fukushima Daiichi Accident

International Nuclear Information System (INIS)

Savage, R.

2016-01-01

This paper provides an overview of the UKs response to the Fukushima Daiichi Accident and highlights the influence that this has had on UK nuclear regulation since March 2011. ONR’s Incident Suite was staffed from the first day of the accident and remained active on a 24 hours basis for over two weeks. The purpose was to provide advice to the UK government specifically prompt assurance of why this accident couldn’t take place in the UK and practical advice in relation to the 17,000 UK nationals in Japan at that time. In the early phase of the accident ONR took part in international cooperation with the US, Canadian and French regulators in order to determine the actual technical status of the Fukushima Daiichi power plant units. The UK Secretary of State requested that the ONR Chief Inspector identify any lessons to be learnt by the UK nuclear industry and in doing so cooperate and coordinate with international colleagues. The Interim report was produced (May 2011) this focused on civil NPP’s, provided background to radiation, technology and regulations. This report compared the Japan situation with the UK and identified 11 conclusions and 26 recommendations.

A fresh start of nuclear safety regulation and international perspective

International Nuclear Information System (INIS)

Oshima, Kenzo

2013-01-01

It should be explained more to the outside modestly the Fukushima nuclear accident would be a man-made complex disaster, which might be reluctant to do but not be neglected. Utmost efforts to change inward-looking attitude and reform safety culture should be done so as to prevent superficial reflection of the Fukushima nuclear accident. Since all nuclear regulatory functions ('3S': safety, security, safeguards) were integrated in Nuclear Regulation Authority (NRA), NRA and secretariat of NRA became more responsible for international response, and strengthening of organization system and human resources development would be an urgent necessity. This article described present stage of NRA focusing on international dimension including personal views. Overseas strong concern over the Fukushima nuclear accident and international communications were reviewed. The Fukushima nuclear accident started from natural disaster and enlarged as a man-made complex disaster with many human factors (mainly inaction, wilful negligence) overlapping and safety culture flawed. Examples of overseas and Japanese action plan to learn and absorb lessons from the Fukushima accident were introduced. NRA's started activities on inviting IAEA's IRRS and OPPAS as soon as ready, strengthening nuclear security measures, safeguards to prevent nuclear proliferation, bilateral cooperation and international advisors were also presented. (T. Tanaka)

Infectious Entry Pathway of Enterovirus B Species

Directory of Open Access Journals (Sweden)

Varpu Marjomäki

2015-12-01

Full Text Available Enterovirus B species (EV-B are responsible for a vast number of mild and serious acute infections. They are also suspected of remaining in the body, where they cause persistent infections contributing to chronic diseases such as type I diabetes. Recent studies of the infectious entry pathway of these viruses revealed remarkable similarities, including non-clathrin entry of large endosomes originating from the plasma membrane invaginations. Many cellular factors regulating the efficient entry have recently been associated with macropinocytic uptake, such as Rac1, serine/threonine p21-activated kinase (Pak1, actin, Na/H exchanger, phospholipace C (PLC and protein kinase Cα (PKCα. Another characteristic feature is the entry of these viruses to neutral endosomes, independence of endosomal acidification and low association with acidic lysosomes. The biogenesis of neutral multivesicular bodies is crucial for their infection, at least for echovirus 1 (E1 and coxsackievirus A9 (CVA9. These pathways are triggered by the virus binding to their receptors on the plasma membrane, and they are not efficiently recycled like other cellular pathways used by circulating receptors. Therefore, the best “markers” of these pathways may be the viruses and often their receptors. A deeper understanding of this pathway and associated endosomes is crucial in elucidating the mechanisms of enterovirus uncoating and genome release from the endosomes to start efficient replication.

Comparative Study Between The IAEA Model Regulations and The Egyptian Nuclear Law

International Nuclear Information System (INIS)

Abaza, A.; Hosni, M.

2015-01-01

This study deals with the security of radioactive sources due to its great importance, in order to provide the adequate security of these sources from the threat of theft, sabotage, illegal seizure through doing a comparison between the model regulations of the International Atomic Energy Agency (IAEA) (11) and the Egyptian law (No. 7/2010) that regulates nuclear and radiation activities and its executive regulations. The Egyptian legislator has put a chapter entitled n uclear security w ith the aim of organizing the security of nuclear materials. However, there was a review to some regulatory rules issued by the IAEA on the security of these sources which include the responsibilities of the licensee towards it. This chapter also, addressed the security culture through rehabilitation and training, in addition to the obligations of the competent authorities who is responsible for the process of issuing the license when full requirements are met. It has been shown that the Egyptian law and its executive regulations contained the rule that provides the necessary protection for these radioactive sources. Furthermore, more regulations are still needed to provide adequate security and more protection for the radioactive sources and its facilities

The Independence of the Nuclear Regulator: Notes from the Canadian Experience

International Nuclear Information System (INIS)

MacKenzie, B.

2010-01-01

The firing of Linda Keen as president and chief executive Officer of the Canadian Nuclear Safety Commission provoked considerable debate within Canada and internationally about the independence of the canadian nuclear regulator. ms. Keen was dismissed from her position from her position at the height of the crisis over a world-wide shortage of medical isotopes caused by the shutdown of the research reactor in Chalk river, Ontario. Under the terms of its licence, the reactor was required to have cooling pumps connected to an emergency power supply as a backup in case of a power outage caused by an event such an earthquake. In november 2007, after it was discovered that the pumps were not connected, the reactor was shut down. As panic over the shortage of medical isotopes grew, the government took three extraordinary measures: first, it issued a directive; second, it introduced emergency legislation in Parliament; and finally, it fired Linda Keen as President of the Commission. This paper examines those three measures and whether they constituted an unwarranted interference with the independence of the Canadian nuclear regulator. (N.C.)

Regulations concerning the transport of nuclear fuel materials outside the works or the enterprise

International Nuclear Information System (INIS)

1979-01-01

The regulations are defined under the law for the regulations of nuclear source materials, nuclear fuel materials and reactors and the order for execution of the law. Basic concepts and terms are explained, such as: vehicle transport; easy transport; nuclear fuel material load, exclusive loading, employee, accumulative dose and exposure dose. Technical standards of vehicle transport are specified in detail on nucler fuel materials as nuclear fuel load, L,A, EM and BU type of load, nuclear fuel load of fission substances, the second and third type of fission load and materials contaminated by nuclear fuel substances to be carried not as nuclear fuel loads. Special exceptional measures to such transport and technical standards of easy transport are also designated. The application for confirmation of the transport shall be filed to the Director General of Science and Technology Agency according to the form attached with documents explaining nuclear fuel materials to be transferred, the vessel of such materials and construction, material and method of production of such a vessel, safety of nuclear materials contained, etc. Measures in dangerous situations shall be taken to fight a fire or prohibit the entrance of persons other than the staff concerned. Reports shall be presented in 10 days to the Director, when theft, loss or irregular leaking of nuclear fuel materials or personal troubles occur on the way. (Okada, K.)

Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export

Directory of Open Access Journals (Sweden)

Marriott Susan J

2007-12-01

Full Text Available Abstract Background The HTLV-I oncoprotein, Tax, is a pleiotropic protein whose activity is partially regulated by its ability to interact with, and perturb the functions of, numerous cellular proteins. Tax is predominantly a nuclear protein that localizes to nuclear foci known as Tax Speckled Structures (TSS. We recently reported that the localization of Tax and its interactions with cellular proteins are altered in response to various forms of genotoxic and cellular stress. The level of cytoplasmic Tax increases in response to stress and this relocalization depends upon the interaction of Tax with CRM1. Cellular pathways and signals that regulate the subcellular localization of Tax remain to be determined. However, post-translational modifications including sumoylation and ubiquitination are known to influence the subcellular localization of Tax and its interactions with cellular proteins. The sumoylated form of Tax exists predominantly in the nucleus while ubiquitinated Tax exists predominantly in the cytoplasm. Therefore, we hypothesized that post-translational modifications of Tax that occur in response to DNA damage regulate the localization of Tax and its interactions with cellular proteins. Results We found a significant increase in mono-ubiquitination of Tax in response to UV irradiation. Mutation of specific lysine residues (K280 and K284 within Tax inhibited DNA damage-induced ubiquitination. In contrast to wild-type Tax, which undergoes transient nucleocytoplasmic shuttling in response to DNA damage, the K280 and K284 mutants were retained in nuclear foci following UV irradiation and remained co-localized with the cellular TSS protein, sc35. Conclusion This study demonstrates that the localization of Tax, and its interactions with cellular proteins, are dynamic following DNA damage and depend on the post-translational modification status of Tax. Specifically, DNA damage induces the ubiquitination of Tax at K280 and K284

Entry into the nuclear pore complex is controlled by a cytoplasmic exclusion zone containing dynamic GLFG-repeat nucleoporin domains.

Science.gov (United States)

Fiserova, Jindriska; Spink, Matthew; Richards, Shane A; Saunter, Christopher; Goldberg, Martin W

2014-01-01

Nuclear pore complexes (NPCs) mediate nucleocytoplasmic movement. The central channel contains proteins with phenylalanine-glycine (FG) repeats, or variations (GLFG, glycine-leucine-phenylalanine-glycine). These are 'intrinsically disordered' and often represent weak interaction sites that become ordered upon interaction. We investigated this possibility during nuclear transport. Using electron microscopy of S. cerevisiae, we show that NPC cytoplasmic filaments form a dome-shaped structure enclosing GLFG domains. GLFG domains extend out of this structure and are part of an 'exclusion zone' that might act as a partial barrier to entry of transport-inert proteins. The anchor domain of a GLFG nucleoporin locates exclusively to the central channel. By contrast, the localisation of the GLFG domains varied between NPCs and could be cytoplasmic, central or nucleoplasmic and could stretch up to 80 nm. These results suggest a dynamic exchange between ordered and disordered states. In contrast to diffusion through the NPC, transport cargoes passed through the exclusion zone and accumulated near the central plane. We also show that movement of cargo through the NPC is accompanied by relocation of GLFG domains, suggesting that binding, restructuring and movement of these domains could be part of the translocation mechanism.

p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1.

Directory of Open Access Journals (Sweden)

Xiao-Su Zhao

Full Text Available Cyclin-dependent kinase 5 (Cdk5 is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity. Cdk5 activity is controlled by its specific activators: p35 or p39. While knockout studies reveal that Cdk5/p35 is critical for neuronal migration during early brain development, functions of Cdk5/p35 have been unraveled through the identification of the interacting proteins of p35, most of which are Cdk5/p35 substrates. However, it remains unclear whether p35 can regulate neuronal functions independent of Cdk5 activity. Here, we report that a nuclear protein, nuclear hormone receptor coregulator (NRC-interacting factor 1 (NIF-1, is a new interacting partner of p35. Interestingly, p35 regulates the functions of NIF-1 independent of Cdk5 activity. NIF-1 was initially discovered as a transcriptional regulator that enhances the transcriptional activity of nuclear hormone receptors. Our results show that p35 interacts with NIF-1 and regulates its nucleocytoplasmic trafficking via the nuclear export pathway. Furthermore, we identified a nuclear export signal on p35; mutation of this site or blockade of the CRM1/exportin-dependent nuclear export pathway resulted in the nuclear accumulation of p35. Intriguingly, blocking the nuclear export of p35 attenuated the nuclear accumulation of NIF-1. These findings reveal a new p35-dependent mechanism in transcriptional regulation that involves the nucleocytoplasmic shuttling of transcription regulators.

p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).

Science.gov (United States)

Zhao, Xiao-Su; Fu, Wing-Yu; Chien, Winnie W Y; Li, Zhen; Fu, Amy K Y; Ip, Nancy Y

2014-01-01

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity. Cdk5 activity is controlled by its specific activators: p35 or p39. While knockout studies reveal that Cdk5/p35 is critical for neuronal migration during early brain development, functions of Cdk5/p35 have been unraveled through the identification of the interacting proteins of p35, most of which are Cdk5/p35 substrates. However, it remains unclear whether p35 can regulate neuronal functions independent of Cdk5 activity. Here, we report that a nuclear protein, nuclear hormone receptor coregulator (NRC)-interacting factor 1 (NIF-1), is a new interacting partner of p35. Interestingly, p35 regulates the functions of NIF-1 independent of Cdk5 activity. NIF-1 was initially discovered as a transcriptional regulator that enhances the transcriptional activity of nuclear hormone receptors. Our results show that p35 interacts with NIF-1 and regulates its nucleocytoplasmic trafficking via the nuclear export pathway. Furthermore, we identified a nuclear export signal on p35; mutation of this site or blockade of the CRM1/exportin-dependent nuclear export pathway resulted in the nuclear accumulation of p35. Intriguingly, blocking the nuclear export of p35 attenuated the nuclear accumulation of NIF-1. These findings reveal a new p35-dependent mechanism in transcriptional regulation that involves the nucleocytoplasmic shuttling of transcription regulators.

Radioactive materials and nuclear fuel transport requirements in Poland in the light of international regulations

International Nuclear Information System (INIS)

Musialowicz, T.

1977-01-01

National regulations for the transport of radioactive materials and nuclear fuel in Poland are discussed. Basic transport requirements and regulations, transport experience including transport accidents and emergency service are described. The comparison with international regulations is given

The Process of Legal Drafting Regulation in the Development of the Nuclear Power Plant in Indonesia

OpenAIRE

Mardha, Amil

2009-01-01

THE PROCESS OF LEGAL DRAFTING REGULATION IN THE DEVELOPMENT OF THE NUCLEAR POWER PLANT IN INDONESIA. In Indonesia, the process of legal drafting to establish the regulation is based on the Act No. 10 Year 2004 on the Establishment of Legislation. The process shall comply with the constitutional and institutional requirements of national political and legal system. In drafting the development of the regulation of nuclear energy, BAPETEN has been involving some other agencies or other related g...

Nuclear deterrents: Intrinsic regulators of IL-1β-induced effects on hippocampal neurogenesis.

Science.gov (United States)

O'Léime, Ciarán S; Cryan, John F; Nolan, Yvonne M

2017-11-01

Hippocampal neurogenesis, the process by which new neurons are born and develop into the host circuitry, begins during embryonic development and persists throughout adulthood. Over the last decade considerable insights have been made into the role of hippocampal neurogenesis in cognitive function and the cellular mechanisms behind this process. Additionally, an increasing amount of evidence exists on the impact of environmental factors, such as stress and neuroinflammation on hippocampal neurogenesis and subsequent impairments in cognition. Elevated expression of the pro-inflammatory cytokine interleukin-1β (IL-1β) in the hippocampus is established as a significant contributor to the neuronal demise evident in many neurological and psychiatric disorders and is now known to negatively regulate hippocampal neurogenesis. In order to prevent the deleterious effects of IL-1β on neurogenesis it is necessary to identify signalling pathways and regulators of neurogenesis within neural progenitor cells that can interact with IL-1β. Nuclear receptors are ligand regulated transcription factors that are involved in modulating a large number of cellular processes including neurogenesis. In this review we focus on the signalling mechanisms of specific nuclear receptors involved in regulating neurogenesis (glucocorticoid receptors, peroxisome proliferator activated receptors, estrogen receptors, and nuclear receptor subfamily 2 group E member 1 (NR2E1 or TLX)). We propose that these nuclear receptors could be targeted to inhibit neuroinflammatory signalling pathways associated with IL-1β. We discuss their potential to be therapeutic targets for neuroinflammatory disorders affecting hippocampal neurogenesis and associated cognitive function. Copyright © 2017 Elsevier Inc. All rights reserved.

Medical student satisfaction, coping and burnout in direct-entry versus graduate-entry programmes.

Science.gov (United States)

DeWitt, Dawn; Canny, Benedict J; Nitzberg, Michael; Choudri, Jennifer; Porter, Sarah

2016-06-01

There is ongoing debate regarding the optimal length of medical training, with concern about the cost of prolonged training. Two simultaneous tracks currently exist in Australia: direct entry from high school and graduate entry for students with a bachelor degree. Medical schools are switching to graduate entry based on maturity, academic preparedness and career-choice surety. We tested the assumption that graduate entry is better by exploring student preferences, coping, burnout, empathy and alcohol use. From a potential pool of 2188 participants, enrolled at five Australian medical schools, a convenience sample of 688 (31%) first and second year students completed a survey in the middle of the academic year. Participants answered questions about demographics, satisfaction and coping and completed three validated instruments. Over 90% of students preferred their own entry-type, though more graduate-entry students were satisfied with their programme (82.4% versus 65.3%, p students in self-reported coping or in the proportion of students meeting criteria for burnout (50.7% versus 51.2%). Direct-entry students rated significantly higher for empathy (concern, p = 0.022; personal distress, p = 0.031). Graduate-entry students reported significantly more alcohol use and hazardous drinking (30.0% versus 22.8%; p = 0.017). Our multi-institution data confirm that students are generally satisfied with their choice of entry pathway and do not confirm significant psychosocial benefits of graduate entry. Overall, our data suggest that direct-entry students cope with the workload and psychosocial challenges of medical school, in the first 2 years, as well as graduate-entry students. Burnout and alcohol use should be addressed in both pathways. Despite studies showing similar academic outcomes, and higher total costs, more programmes in Australia are becoming graduate entry. Further research on non-cognitive issues and outcomes is needed so that universities, government

Nuclear movement regulated by non-Smad Nodal signaling via JNK is associated with Smad signaling during zebrafish endoderm specification.

Science.gov (United States)

Hozumi, Shunya; Aoki, Shun; Kikuchi, Yutaka

2017-11-01

Asymmetric nuclear positioning is observed during animal development, but its regulation and significance in cell differentiation remain poorly understood. Using zebrafish blastulae, we provide evidence that nuclear movement towards the yolk syncytial layer, which comprises extraembryonic tissue, occurs in the first cells fated to differentiate into the endoderm. Nodal signaling is essential for nuclear movement, whereas nuclear envelope proteins are involved in movement through microtubule formation. Positioning of the microtubule-organizing center, which is proposed to be crucial for nuclear movement, is regulated by Nodal signaling and nuclear envelope proteins. The non-Smad JNK signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad pathway, and this nuclear movement is associated with Smad signal transduction toward the nucleus. Our study provides insight into the function of nuclear movement in Smad signaling toward the nucleus, and could be applied to the control of TGFβ signaling. © 2017. Published by The Company of Biologists Ltd.

Legal and administrative problems in regulating public participation in licensing of nuclear installations

International Nuclear Information System (INIS)

Cornelis, J.C.

1981-10-01

This general analysis of the question of public acceptance of nuclear activities focuses on the problems met by all governmental authorities in implementing their nuclear programmes. The author highlights the need for more specific regulations aimed at guaranteeing fuller information of the public and ensuring closer participation by it. (NEA) [fr

Regulations for the safe management of radioactive wastes and spent nuclear fuel

International Nuclear Information System (INIS)

Voica, Anca

2007-01-01

The paper presents the national, international and European regulations regarding radioactive waste management. ANDRAD is the national authority charged with nation wide coordination of safe management of spent fuel and radioactive waste including their final disposal. ANDRAD's main objectives are the following: - establishing the National Strategy concerning the safety management of radioactive waste and spent nuclear fuel; - establishing the national repositories for the final disposal of the spent nuclear fuel and radioactive waste; - developing the technical procedures and establishing norms for all stages of management of spent nuclear fuel and radioactive waste, including the disposal and the decommissioning of the nuclear and radiologic facilities

32 CFR 552.36 - Rights-of-entry for construction.

Science.gov (United States)

2010-07-01

... AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Acquisition of Real Estate and... construction will be obtained by the district engineer only after a real estate directive or authorization to... 32 National Defense 3 2010-07-01 2010-07-01 true Rights-of-entry for construction. 552.36 Section...

Concerning major items in government ordinance requiring modification of part of enforcement regulation for law relating to control of nuclear material, nuclear fuel and nuclear reactor

International Nuclear Information System (INIS)

1989-01-01

The report describes major items planned to be incorporated into the enforcement regulations for laws relating to control of nuclear material, nuclear fuel and nuclear reactor. The modifications have become necessary for the nation to conclude a nuclear material protection treaty with other countries. The modification include the definitions of 'special nuclear fuel substances' and 'special nuclear fuel substances' and 'special nuclear fuel substances subject to protection'. The modifications require that protective measures be taken when handling and transporting special nuclear fuel substances subject to protection. Transport of special nuclear fuel substances requires approval from the Prime Minister or Transport Minister. Transport of special nuclear fuel substances subject to protection should be conducted after notifying the prefectural Public Safety Commission. Transport of special nuclear fuel substances subject to protection requires the conclusion of arrangements among responsible persons and approval of them from the Prime Minister. (N.K.)

The regulator as nuclear communicator

International Nuclear Information System (INIS)

Beecher, William

2000-01-01

Early last year the Nuclear Regulatory Commission decided on a sea-change in the way it inspects and evaluates the safety performance of the 103 commercial nuclear power reactors in the United States, which together produce about 20 percent of the nation's electricity. The new program takes into account the improvements in performance of the U.S. nuclear industry over the past 20 years and the NRC's desire to apply more objective, timely, safety significant criteria in assessing performance, as well as the need to effectively regulate at a time of shrinking staff and budgets. There also was a desire to increase efficiency and reduce unnecessary regulatory burden on plant operators as they begin to transition from their traditional postures as regional monopolies, with rates fixed by local public utility commissions, into a highly competitive deregulated energy marketplace. A pilot project was decided upon to test the new approach at thirteen power plants at nine sites. At first the pilot was to have run six months, but this was subsequently extended. The current timetable, which itself is subject to change, would review the results of the pilot program, make prudent adjustments, and apply it to the entire industry this spring. To explain the entirely new procedures, the technical staff produced a thick document which Albert Einstein-on his best day-would have had trouble understanding. Thus we found ourselves on the verge of what might have been a public perception disaster undermining faith that the NRC was determined to fulfill our transcendent mission and responsibility to protect public health and safety in the application of nuclear power. The first thing we required was a relatively brief plain language translation, of the highly technical staff paper into something any interested member of the public could readily understand. We urgently needed a clear and simple primer to explain the new program, its rationale, and its advantages over the old approach. In

Guidelines for authorities and operators from the EURATOM regulation according to nuclear safety

International Nuclear Information System (INIS)

Karpenstein, Ulrich

2010-01-01

At 22nd July, 2009 the guideline 2009/71/EURATOM on a community framework for the nuclear security of nuclear installations comes into effect. A lot of regulations of this guideline intervene very deeply in the competencies of the member states. In acknowledgment of the national responsibility for nuclear security, the guideline grants large free space to the member states. Thereby, the guideline aims at a general legal framework and a mutual learning process off.

Controlling the atom. The beginnings of nuclear regulation 1946--1962

Energy Technology Data Exchange (ETDEWEB)

Mazuzan, G.T.; Walker, J.S.

1997-08-01

This book traces the early history of nuclear power regulation in the US. It focuses on the Atomic Energy Commission (AEC), the federal agency that until 1975 was primarily responsible for planning and carrying out programs to protect public health and safety from the hazards of the civilian use of nuclear energy. It also describes the role of other groups that figured significantly in the development of regulatory policies, including the congressional Joint Committee on Atomic Energy, federal agencies other than the AEC, state governments, the nuclear industry, and scientific organizations. And it considers changes in public perceptions of and attitudes toward atomic energy and the dangers of radiation exposure. The context in which regulatory programs evolved is a rich and complex mixture of political, legislative, legal, technological, scientific, and administrative history. The basic purpose of this book is to provide the Nuclear Regulatory Commission (NRC), which inherited responsibility for nuclear safety after Congress disbanded the AEC, and the general public with information on the historical antecedents and background of regulatory issues.

The primeval fear of nuclear energy

International Nuclear Information System (INIS)

Broda, E.

1979-01-01

This text, written by E. Broda, in 1979 is about the primeval fear of nuclear energy. He analyses amongst other things apocalyptic visions of people, weapon plutonium from nuclear power plants, nuclear power plants in critical situations and the entry into the atomic age. (nowak)

Identification of a chemical inhibitor for nuclear speckle formation: Implications for the function of nuclear speckles in regulation of alternative pre-mRNA splicing

Energy Technology Data Exchange (ETDEWEB)

Kurogi, Yutaro; Matsuo, Yota; Mihara, Yuki; Yagi, Hiroaki; Shigaki-Miyamoto, Kaya; Toyota, Syukichi; Azuma, Yuko [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Chuo-ku, Kumamoto 860-8555 (Japan); Igarashi, Masayuki [Laboratory of Disease Biology, Institute of Microbial Chemistry, Shinagawa-ku, Tokyo 141-0021 (Japan); Tani, Tokio, E-mail: ttani@sci.kumamoto-u.ac.jp [Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Chuo-ku, Kumamoto 860-8555 (Japan)

2014-03-28

Highlights: • We identified tubercidin as a compound inducing aberrant formation of the speckles. • Tubercidin causes delocalization of poly (A){sup +}RNAs from nuclear speckles. • Tubercidin induces dispersion of splicing factors from nuclear speckles. • Tubercidin affects alternative pre-mRNA splicing. • Nuclear speckles play a role in regulation of alternative pre-mRNA splicing. - Abstract: Nuclear speckles are subnuclear structures enriched with RNA processing factors and poly (A){sup +} RNAs comprising mRNAs and poly (A){sup +} non-coding RNAs (ncRNAs). Nuclear speckles are thought to be involved in post-transcriptional regulation of gene expression, such as pre-mRNA splicing. By screening 3585 culture extracts of actinomycetes with in situ hybridization using an oligo dT probe, we identified tubercidin, an analogue of adenosine, as an inhibitor of speckle formation, which induces the delocalization of poly (A){sup +} RNA and dispersion of splicing factor SRSF1/SF2 from nuclear speckles in HeLa cells. Treatment with tubercidin also decreased steady-state MALAT1 long ncRNA, thought to be involved in the retention of SRSF1/SF2 in nuclear speckles. In addition, we found that tubercidin treatment promoted exon skipping in the alternative splicing of Clk1 pre-mRNA. These results suggest that nuclear speckles play a role in modulating the concentration of splicing factors in the nucleoplasm to regulate alternative pre-mRNA splicing.

31 CFR 515.207 - Entry of vessels engaged in trade with Cuba.

Science.gov (United States)

2010-07-01

... with Cuba. 515.207 Section 515.207 Money and Finance: Treasury Regulations Relating to Money and... REGULATIONS Prohibitions § 515.207 Entry of vessels engaged in trade with Cuba. Except as specifically... place in Cuba to engage in the trade of goods or the purchase or provision of services, may enter a U.S...

Sweden: The Swedish nuclear archive regulations and projects related to corporate memory. Annex I-2

International Nuclear Information System (INIS)

2008-01-01

The Swedish radiation protection authority regulations on Filing at Nuclear Plants, SSI FS 1997:1, apply to filing of documentation that has been drawn up or received in connection with practices at nuclear plants. The regulations set out: -The minimum level of documentation; - Archiving requirements; -Availability periods; - Choice of data carrier; - Timely transfer to new media; - Requirements regarding safe keeping of documents. The regulations require that, if the nuclear activity ceases, the archives must be transferred to the Swedish national archives. Examples of the availability periods required for records and environmental specimens are as follows: (a) Operations related measurements - 25 years; (b) Emergency response plan - 50 years; (c) Report of an unusual event - 50 years; (d) Documents relating to final disposal - long term; (e) Environmental specimens - 10 years; (f) Records of measurements on specimens - long term

Quantitative membrane proteomics reveals a role for tetraspanin enriched microdomains during entry of human cytomegalovirus.

Directory of Open Access Journals (Sweden)

Kasinath Viswanathan

Full Text Available Human cytomegalovirus (HCMV depends on and modulates multiple host cell membrane proteins during each stage of the viral life cycle. To gain a global view of the impact of HCMV-infection on membrane proteins, we analyzed HCMV-induced changes in the abundance of membrane proteins in fibroblasts using stable isotope labeling with amino acids (SILAC, membrane fractionation and protein identification by two-dimensional liquid chromatography and tandem mass spectrometry. This systematic approach revealed that CD81, CD44, CD98, caveolin-1 and catenin delta-1 were down-regulated during infection whereas GRP-78 was up-regulated. Since CD81 downregulation was also observed during infection with UV-inactivated virus we hypothesized that this tetraspanin is part of the viral entry process. Interestingly, additional members of the tetraspanin family, CD9 and CD151, were also downregulated during HCMV-entry. Since tetraspanin-enriched microdomains (TEM cluster host cell membrane proteins including known CMV receptors such as integrins, we studied whether TEMs are required for viral entry. When TEMs were disrupted with the cholesterol chelator methyl-β-cylcodextrin, viral entry was inhibited and this inhibition correlated with reduced surface levels of CD81, CD9 and CD151, whereas integrin levels remained unchanged. Furthermore, simultaneous siRNA-mediated knockdown of multiple tetraspanins inhibited viral entry whereas individual knockdown had little effect suggesting essential, but redundant roles for individual tetraspanins during entry. Taken together, our data suggest that TEM act as platforms for receptors utilized by HCMV for entry into cells.

Isolation of nuclear proteins from flax (Linum usitatissimum L. seed coats for gene expression regulation studies

Directory of Open Access Journals (Sweden)

Renouard Sullivan

2012-01-01

Full Text Available Abstract Background While seed biology is well characterized and numerous studies have focused on this subject over the past years, the regulation of seed coat development and metabolism is for the most part still non-elucidated. It is well known that the seed coat has an essential role in seed development and its features are associated with important agronomical traits. It also constitutes a rich source of valuable compounds such as pharmaceuticals. Most of the cell genetic material is contained in the nucleus; therefore nuclear proteins constitute a major actor for gene expression regulation. Isolation of nuclear proteins responsible for specific seed coat expression is an important prerequisite for understanding seed coat metabolism and development. The extraction of nuclear proteins may be problematic due to the presence of specific components that can interfere with the extraction process. The seed coat is a rich source of mucilage and phenolics, which are good examples of these hindering compounds. Findings In the present study, we propose an optimized nuclear protein extraction protocol able to provide nuclear proteins from flax seed coat without contaminants and sufficient yield and quality for their use in transcriptional gene expression regulation by gel shift experiments. Conclusions Routinely, around 250 μg of nuclear proteins per gram of fresh weight were extracted from immature flax seed coats. The isolation protocol described hereafter may serve as an effective tool for gene expression regulation and seed coat-focused proteomics studies.

DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells.

Science.gov (United States)

Kruitwagen, Hedwig S; Westendorp, Bart; Viebahn, Cornelia S; Post, Krista; van Wolferen, Monique E; Oosterhoff, Loes A; Egan, David A; Delabar, Jean-Maurice; Toussaint, Mathilda J; Schotanus, Baukje A; de Bruin, Alain; Rothuizen, Jan; Penning, Louis C; Spee, Bart

2018-01-15

Hepatic progenitor cells (HPCs) are adult liver stem cells that act as second line of defense in liver regeneration. They are normally quiescent, but in case of severe liver damage, HPC proliferation is triggered by external activation mechanisms from their niche. Although several important proproliferative mechanisms have been described, it is not known which key intracellular regulators govern the switch between HPC quiescence and active cell cycle. We performed a high-throughput kinome small interfering RNA (siRNA) screen in HepaRG cells, a HPC-like cell line, and evaluated the effect on proliferation with a 5-ethynyl-2'-deoxyuridine (EdU) incorporation assay. One hit increased the percentage of EdU-positive cells after knockdown: dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A). Although upon DYRK1A silencing, the percentage of EdU- and phosphorylated histone H3 (pH3)-positive cells was increased, and total cell numbers were not increased, possibly through a subsequent delay in cell cycle progression. This phenotype was confirmed with chemical inhibition of DYRK1A using harmine and with primary HPCs cultured as liver organoids. DYRK1A inhibition impaired Dimerization Partner, RB-like, E2F, and multivulva class B (DREAM) complex formation in HPCs and abolished its transcriptional repression on cell cycle progression. To further analyze DYRK1A function in HPC proliferation, liver organoid cultures were established from mBACtgDyrk1A mice, which harbor one extra copy of the murine Dyrk1a gene (Dyrk+++). Dyrk+++ organoids had both a reduced percentage of EdU-positive cells and reduced proliferation compared with wild-type organoids. This study provides evidence for an essential role of DYRK1A as balanced regulator of S-phase entry in HPCs. An exact gene dosage is crucial, as both DYRK1A deficiency and overexpression affect HPC cell cycle progression.

Export of nuclear equipment and materials and the non-proliferation of nuclear weapons

International Nuclear Information System (INIS)

Courteix, Simone.

1977-01-01

The problem of the non-proliferation of nuclear weapons is one of great concern today despite the entry into force in the early '70s of the NPT. To master civilian nuclear technology implies the ability to develop nuclear explosive devices; therefore in recent years contacts have strengthened between countries exporting nuclear equipment, specially in the frame of the 'London Club' so as to ensure that their exports will not result in disseminating nuclear weapons. (NEA) [fr

78 FR 71675 - Update of the Office of Nuclear Reactor Regulation's Electronic Operating Reactor Correspondence

Science.gov (United States)

2013-11-29

... NUCLEAR REGULATORY COMMISSION [NRC-2013-0260] Update of the Office of Nuclear Reactor Regulation's Electronic Operating Reactor Correspondence The U.S. Nuclear Regulatory Commission (NRC) is issuing this Federal Register notice to inform the public of a slight change in the manner of distribution of publicly available operating reactor licensing...

Improved nuclear power plant operations through performance-based safety regulation

International Nuclear Information System (INIS)

Golay, M.W.

1998-01-01

The US Nuclear Regulatory Commission (NRC) has recently instituted use of Risk-Informed, Performance-Based Regulation (RIPBR) for protecting public safety in the use of nuclear power. This was done most importantly during June 1997 in issuance of revised Regulatory Guides and Standard Review Plan (SRP) guidance to licensees and the NRC staff. The propose of RIPBR is to replace the previously-used system of prescriptive regulation, which focuses upon what licensees must do, to a system which focuses upon what they must achieve. RIPBR is goals-oriented and the previous system is means-oriented. This regulatory change is potentially revolutionary, and offers many opportunities for improving the efficiency of improving both nuclear power operations and safety. However, it must be nurtured carefully if is to be successful. The work reported in this paper is concerned with showing how RIPBR can be implemented successfully, with benefits in both areas being attained. It is also concerned with how several of the practical barriers to establishing a workable new regulatory system can be overcome. This work, sponsored by the US Dept. of Energy, is being performed in collaboration with Northeast Utilities Services Crop. and the Idaho National Engineering Laboratory. In our work we have examined a practical safety-related example at the Millstone 3 nuclear power station for implementation of RIPBR. In this examination we have formulated a set of modifications to the plant's technical specifications, and are in the process of investigating their bases and refining the modifications. (author)

Regulation of p53 tetramerization and nuclear export by ARC.

Science.gov (United States)

Foo, Roger S-Y; Nam, Young-Jae; Ostreicher, Marc Jason; Metzl, Mark D; Whelan, Russell S; Peng, Chang-Fu; Ashton, Anthony W; Fu, Weimin; Mani, Kartik; Chin, Suet-Feung; Provenzano, Elena; Ellis, Ian; Figg, Nichola; Pinder, Sarah; Bennett, Martin R; Caldas, Carlos; Kitsis, Richard N

2007-12-26

Inactivation of the transcription factor p53 is central to carcinogenesis. Yet only approximately one-half of cancers have p53 loss-of-function mutations. Here, we demonstrate a mechanism for p53 inactivation by apoptosis repressor with caspase recruitment domain (ARC), a protein induced in multiple cancer cells. The direct binding in the nucleus of ARC to the p53 tetramerization domain inhibits p53 tetramerization. This exposes a nuclear export signal in p53, triggering Crm1-dependent relocation of p53 to the cytoplasm. Knockdown of endogenous ARC in breast cancer cells results in spontaneous tetramerization of endogenous p53, accumulation of p53 in the nucleus, and activation of endogenous p53 target genes. In primary human breast cancers with nuclear ARC, p53 is almost always WT. Conversely, nearly all breast cancers with mutant p53 lack nuclear ARC. We conclude that nuclear ARC is induced in cancer cells and negatively regulates p53.

Determination of internationally controlled materials according to provisions of the law for the regulations of nuclear source materials, nuclear fuel materials and reactors

International Nuclear Information System (INIS)

1981-01-01

This rule is established under the provisions of the law concerning the regulation of nuclear raw materials, nuclear fuel materials and reactors, and the former notification No. 26, 1961, is hereby abolished. Internationally regulated goods under the law are as follows: nuclear raw materials, nuclear fuel materials and moderator materials transferred by sale or other means from the governments of the U.S., U.K., Canada, Australia and France or the persons under their jurisdictions according to the agreements concluded between the governments of Japan and these countries, respectively, the nuclear fuel materials recovered from these materials or produced by their usage, nuclear reactors, the facilities and heavy water transferred by sale or other means from these governments or the persons under their jurisdictions, the nuclear fuel materials produced by the usage of such reactors, facilities and heavy water, the nuclear fuel materials sold by the International Atomic Energy Agency under the contract between the Japanese government and the IAEA, the nuclear fuel materials recovered from these materials or produced by their usage, the heavy water produced by the facilities themselves transferred from the Canadian government, Canadian governmental enterprises or the persons under the jurisdiction of the Canadian government or produced by the usage of these facilities, etc. (Okada, K.)

Parsing glucose entry into the brain: novel findings obtained with enzyme-based glucose biosensors.

Science.gov (United States)

Kiyatkin, Eugene A; Wakabayashi, Ken T

2015-01-21

Extracellular levels of glucose in brain tissue reflect dynamic balance between its gradient-dependent entry from arterial blood and its use for cellular metabolism. In this work, we present several sets of previously published and unpublished data obtained by using enzyme-based glucose biosensors coupled with constant-potential high-speed amperometry in freely moving rats. First, we consider basic methodological issues related to the reliability of electrochemical measurements of extracellular glucose levels in rats under physiologically relevant conditions. Second, we present data on glucose responses induced in the nucleus accumbens (NAc) by salient environmental stimuli and discuss the relationships between local neuronal activation and rapid glucose entry into brain tissue. Third, by presenting data on changes in NAc glucose induced by intravenous and intragastric glucose delivery, we discuss other mechanisms of glucose entry into the extracellular domain following changes in glucose blood concentrations. Lastly, by showing the pattern of NAc glucose fluctuations during glucose-drinking behavior, we discuss the relationships between "active" and "passive" glucose entry to the brain, its connection to behavior-related metabolic activation, and the possible functional significance of these changes in behavioral regulation. These data provide solid experimental support for the "neuronal" hypothesis of neurovascular coupling, which postulates the critical role of neuronal activity in rapid regulation of vascular tone, local blood flow, and entry of glucose and oxygen to brain tissue to maintain active cellular metabolism.

Nuclear safety: economic analysis of American, French and Japanese regulations

International Nuclear Information System (INIS)

Leveque, Francois

2013-05-01

While discussing and comparing the American, Japanese and French approaches and practices, and identifying the strengths and weaknesses of each of them, the author discusses why self-regulation and civil responsibility cannot guarantee a sufficient nuclear safety level, why the safety regulation authority must be independent from industry and government, whether a figure must be put to the safety objective (for example with a risk threshold), whether it is better to define detailed standards to be applied by manufacturers and operators or to define general performance criteria to be reached

Abbreviations of nuclear power plant engineering

International Nuclear Information System (INIS)

Freyberger, G.H.

1979-01-01

The edition of this English and German list of abbreviations comprises about 5200 entries in English and about 1400 entries in German as well as the most important American, English, German and other foreign Utilities and component manufacturers frequently quoted in nuclear engineering literature and documentation. (orig./HP) [de

Regulations concerning the fabricating business of nuclear fuel materials

International Nuclear Information System (INIS)

1987-01-01

Regulations specified here cover application for such matters as permission for an undertaking of processing, alteration (of location, structure, arrangements, processing method, etc.), approval of design and construction plan, approval of alteration (of design and construction plan of processing facilities), and inspection of the facilities. The regulations also cover execution of facilities inspection, certificate of facilities inspection, processing facilities subject to welding inspection, application for welding inspection, execution of welding inspection, facilities not subject to welding inspection, approval of welding method, welding inspection for imported equipment, certificate of welding inspection, application for approval of joint management, notice of alteration, etc., cancellation of permission, record keeping, restriction on access to areas under management measures concerning exposure to radioactive rays, patrol and checking in processing facilities, operation of processing equipment, transportation within plant or operation premises, storage, waste disposal within plant or operation premises, safety rules, public notification concerning examination and successful applicants, procedure for application for examination, reissue of certificate for nuclear fuel handling expert, return of certificate for nuclear fuel handling expert, submission of report, measures for emergency, notice of abolition of business, measures concerning cancellation of permission, identification card, etc. (Nogami, K.)

Nuclear energy in the Philippines

International Nuclear Information System (INIS)

1977-03-01

This bibliography was prepared by the Scientific Library, Nuclear Training Department of the Philippine Atomic Energy Commission for scientists and researchers interested in nuclear energy in the Philippines. This sixth supplement consists of eighty-six (86) entries, mostly research reports of the scientists of the Philippine Atomic Energy Commission. The entries are arranged alphabetically by titles under their respective subject headings together with their bibliographic data consisting of author, title of publication, volume, data and pages. A brief annotation or a summary of the article follows. An author index is provided to facilitate prompt retrieval of the particular research information

Cholesterol regulates DAF-16 nuclear localization and fasting-induced longevity in C. elegans.

Science.gov (United States)

Ihara, Akiko; Uno, Masaharu; Miyatake, Koichi; Honjoh, Sakiko; Nishida, Eisuke

2017-01-01

Cholesterol has attracted significant attention as a possible lifespan regulator. It has been reported that serum cholesterol levels have an impact on mortality due to age-related disorders such as cardiovascular disease. Diet is also known to be an important lifespan regulator. Dietary restriction retards the onset of age-related diseases and extends lifespan in various organisms. Although cholesterol and dietary restriction are known to be lifespan regulators, it remains to be established whether cholesterol is involved in dietary restriction-induced longevity. Here, we show that cholesterol deprivation suppresses longevity induced by intermittent fasting, which is one of the dietary restriction regimens that effectively extend lifespan. We also found that cholesterol is required for the fasting-induced upregulation of transcriptional target genes such as the insulin/IGF-1 pathway effector DAF-16 and that cholesterol deprivation suppresses the long lifespan of the insulin/IGF-1 receptor daf-2 mutant. Remarkably, we found that cholesterol plays an important role in the fasting-induced nuclear accumulation of DAF-16. Moreover, knockdown of the cholesterol-binding protein NSBP-1, which has been shown to bind to DAF-16 in a cholesterol-dependent manner and to regulate DAF-16 activity, suppresses both fasting-induced longevity and DAF-16 nuclear accumulation. Furthermore, this suppression was not additive to the cholesterol deprivation-induced suppression, which suggests that NSBP-1 mediates, at least in part, the action of cholesterol to promote fasting-induced longevity and DAF-16 nuclear accumulation. These findings identify a novel role for cholesterol in the regulation of lifespan. Copyright © 2016 Elsevier Inc. All rights reserved.

Nuclear receptor 4a3 (nr4a3 regulates murine mast cell responses and granule content.

Directory of Open Access Journals (Sweden)

Gianni Garcia-Faroldi

Full Text Available Nuclear receptor 4a3 (Nr4a3 is a transcription factor implicated in various settings such as vascular biology and inflammation. We have recently shown that mast cells dramatically upregulate Nuclear receptor 4a3 upon activation, and here we investigated the functional impact of Nuclear receptor 4a3 on mast cell responses. We show that Nuclear receptor 4a3 is involved in the regulation of cytokine/chemokine secretion in mast cells following activation via the high affinity IgE receptor. Moreover, Nuclear receptor 4a3 negatively affects the transcript and protein levels of mast cell tryptase as well as the mast cell's responsiveness to allergen. Together, these findings identify Nuclear receptor 4a3 as a novel regulator of mast cell function.

Nuclear regulation. License renewal questions for nuclear plants need to be resolved

International Nuclear Information System (INIS)

Fultz, Keith O.; Kruslicky, Mary Ann; McDowell, William D. Jr.; Coleman, Robert L.

1989-04-01

A December 1986 pipe rupture at Virginia Power's Surry unit 2 nuclear power plant injured eight workers; four later died. As a result of this accident, Representative Edward J. Markey requested GAO to examine the Surry accident and assess the problems confronting aging nuclear plants. In March 1988 we reported our findings concerning the accident and a July 1987 incident at the Trojan nuclear plant in Oregon. This report addresses problems confronting aging nuclear plants by examining the Nuclear Regulatory Commission's (NRC) program to develop a license renewal policy and accompanying regulations, and the initiatives underway by the Department of Energy (DOE) and the electric utility industry to extend the operating lives of these plants. Nuclear power has become second only to coal as the largest producer of electricity in the United States. The 110 nuclear plants currently in service are operated by 54 utilities, provide about 20 percent of the nation's electricity, and represent a capital investment of over $200 billion. The Atomic Energy Act authorizes NRC to issue nuclear plant operating licenses for up to 40 years and provides for license extensions beyond the initial operating period. The act does not, however, stipulate the criteria for evaluating a utility request to operate a nuclear plant longer than 40 years. The oldest operating license currently in effect will expire in the year 2000. According to NRC, about one-half of the existing operating licenses will terminate by the year 2015, and most licenses will expire by about 2030. Many utilities will have to decide in the early 1990s whether to continue operating older nuclear plants or to construct new generating capacity. A clear understanding of the terms and conditions governing the license renewal process will be a key element in deciding how to meet future electricity demand. Although NRC has developed 3 possible license renewal policy options and identified 15 areas of regulatory uncertainty that

The evolving image and role of the regulator for implementing repositories for nuclear waste and spent nuclear fuel

International Nuclear Information System (INIS)

Melin, J.

2005-01-01

A country introducing nuclear power in their energy strategy has a life long obligation. The obligation is not mainly a question of energy production. It is an obligation to maintain safety during the phase of construction, energy production and decommissioning as well as to take care of all the waste streams from nuclear installations. I believe that one of the most controversial siting projects in the society is a waste repository for spent nuclear fuel. Competence, available funds and a clear responsibility between the stakeholders as well as the trust of the public is indispensable to obtain a good result. The Swedish programme for managing nuclear waste and spent nuclear fuel has been in progress for more than 25 years. The pre-licensing process of a repository for spent nuclear fuel is much alike a pre-licensing process for the first nuclear power plant in a country. You need a clear political will, you have to involve the nuclear regulator without jeopardizing his integrity and you need the money to perform research and make the investments. The enthusiasm of politicians and industry may however differ between these two projects. (author)

COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport

International Nuclear Information System (INIS)

Wang, Ying-Nai; Wang, Hongmei; Yamaguchi, Hirohito; Lee, Hong-Jen; Lee, Heng-Huan; Hung, Mien-Chie

2010-01-01

Research highlights: → ARF1 activation is involved in the EGFR transport to the ER and the nucleus. → Assembly of γ-COP coatomer mediates EGFR transport to the ER and the nucleus. → Golgi-to-ER retrograde trafficking regulates nuclear transport of EGFR. -- Abstract: Emerging evidence indicates that cell surface receptors, such as the entire epidermal growth factor receptor (EGFR) family, have been shown to localize in the nucleus. A retrograde route from the Golgi to the endoplasmic reticulum (ER) is postulated to be involved in the EGFR trafficking to the nucleus; however, the molecular mechanism in this proposed model remains unexplored. Here, we demonstrate that membrane-embedded vesicular trafficking is involved in the nuclear transport of EGFR. Confocal immunofluorescence reveals that in response to EGF, a portion of EGFR redistributes to the Golgi and the ER, where its NH 2 -terminus resides within the lumen of Golgi/ER and COOH-terminus is exposed to the cytoplasm. Blockage of the Golgi-to-ER retrograde trafficking by brefeldin A or dominant mutants of the small GTPase ADP-ribosylation factor, which both resulted in the disassembly of the coat protein complex I (COPI) coat to the Golgi, inhibit EGFR transport to the ER and the nucleus. We further find that EGF-dependent nuclear transport of EGFR is regulated by retrograde trafficking from the Golgi to the ER involving an association of EGFR with γ-COP, one of the subunits of the COPI coatomer. Our findings experimentally provide a comprehensive pathway that nuclear transport of EGFR is regulated by COPI-mediated vesicular trafficking from the Golgi to the ER, and may serve as a general mechanism in regulating the nuclear transport of other cell surface receptors.

French regulations for countering external violent forces affecting nuclear power stations

International Nuclear Information System (INIS)

Dupraz, B.

1986-01-01

This article describes the general principles underlying nuclear safety regulations to counter external violent forces to which plants can be exposed. It then examines the statutory directives concerning external violences connected with human activities or originating from natural phenomena. 3 refs [fr

New requirements, rules and regulations, and vested rights of nuclear power plants

International Nuclear Information System (INIS)

Raetzke, C.

2006-01-01

The article deals with the question whether new requirements can be imposed on existing nuclear power plants. It was promoted by the fact that the German Federal Ministry for the Environment currently is working on a thorough revision of German nuclear regulations. When looking at backfitting requirements, the all-important question is whether new findings show that the provisions taken in the license to guarantee the 'necessary precautions' (as defined in the German Atomic Energy Act) contain errors or omissions; only in this case can the authority demand that remedial measures, including backfitting, be taken. Beyond that, German nuclear law contains no obligation for operators to improve and develop safety still further. This applies regardless of whether new requirements are justified by new technical possibilities or new scientific analyses or whether they are prompted by a mere abstract re-evaluation of the safety level to be achieved. In the former case, if there are good technical or scientific reasons, the operators, as a rule, will perform backfitting voluntarily. Pursuant to these criteria, the article covers three categories of backfitting requirements and illustrates them by examples. These general principles are also valid when a new set of regulations - as planned by the BMU - are put into effect and applied. They may lead to existing plants not having to comply fully with the requirements contained in new regulations. (orig.)

31 CFR 363.22 - Who has the right to conduct online transactions in book-entry securities?

Science.gov (United States)

2010-07-01

... TreasuryDirect § 363.22 Who has the right to conduct online transactions in book-entry securities? (a... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Who has the right to conduct online transactions in book-entry securities? 363.22 Section 363.22 Money and Finance: Treasury Regulations Relating...

US Ports of Entry

Data.gov (United States)

Department of Homeland Security — HSIP Non-Crossing Ports-of-Entry A Port of Entry is any designated place at which a CBP officer is authorized to accept entries of merchandise to collect duties, and...

The Swedish Radiation Protection Institute's regulations concerning the final management of spent nuclear fuel and nuclear waste - with background and comments

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-11-01

This report presents and comments on the Swedish Radiation Protection Institute's Regulations concerning the Protection of Human Health and the Environment in connection with the Final Management of Spent Nuclear Fuel or Nuclear Waste, SSI FS 1998: 1.

An N-terminal nuclear localization sequence but not the calmodulin-binding domain mediates nuclear localization of nucleomorphin, a protein that regulates nuclear number in Dictyostelium

International Nuclear Information System (INIS)

Myre, Michael A.; O'Day, Danton H.

2005-01-01

Nucleomorphin is a novel nuclear calmodulin (CaM)-binding protein (CaMBP) containing an extensive DEED (glu/asp repeat) domain that regulates nuclear number. GFP-constructs of the 38 kDa NumA1 isoform localize as intranuclear patches adjacent to the inner nuclear membrane. The translocation of CaMBPs into nuclei has previously been shown by others to be mediated by both classic nuclear localization sequences (NLSs) and CaM-binding domains (CaMBDs). Here we show that NumA1 possesses a CaMBD ( 171 EDVSRFIKGKLLQKQQKIYKDLERF 195 ) containing both calcium-dependent-binding motifs and an IQ-like motif for calcium-independent binding. GFP-constructs containing only NumA1 residues 1-129, lacking the DEED and CaMBDs, still localized as patches at the internal periphery of nuclei thus ruling out a direct role for the CaMBD in nuclear import. These constructs contained the amino acid residues 48 KKSYQDPEIIAHSRPRK 64 that include both a putative bipartite and classical NLS. GFP-bipartite NLS constructs localized uniformly within nuclei but not as patches. As with previous work, removal of the DEED domain resulted in highly multinucleate cells. However as shown here, multinuclearity only occurred when the NLS was present allowing the protein to enter nuclei. Site-directed mutation analysis in which the NLS was changed to 48 EF 49 abolished the stability of the GFP fusion at the protein but not RNA level preventing subcellular analyses. Cells transfected with the 48 EF 49 construct exhibited slowed growth when compared to parental AX3 cells and other GFP-NumA1 deletion mutants. In addition to identifying an NLS that is sufficient for nuclear translocation of nucleomorphin and ruling out CaM-binding in this event, this work shows that the nuclear localization of NumA1 is crucial to its ability to regulate nuclear number in Dictyostelium

RNase L Interacts with Filamin A To Regulate Actin Dynamics and Barrier Function for Viral Entry

Science.gov (United States)

Siddiqui, Mohammad Adnan; Dayal, Shubham; Naji, Merna; Ezelle, Heather J.; Zeng, Chun; Zhou, Aimin; Hassel, Bret A.

2014-01-01

ABSTRACT The actin cytoskeleton and its network of associated proteins constitute a physical barrier that viruses must circumvent to gain entry into cells for productive infection. The mechanisms by which the physical signals of infection are sensed by the host to activate an innate immune response are not well understood. The antiviral endoribonuclease RNase L is ubiquitously expressed in a latent form and activated upon binding 2-5A, a unique oligoadenylate produced during viral infections. We provide evidence that RNase L in its inactive form interacts with the actin-binding protein Filamin A to modulate the actin cytoskeleton and inhibit virus entry. Cells lacking either RNase L or Filamin A displayed increased virus entry which was exacerbated in cells lacking both proteins. RNase L deletion mutants that reduced Filamin A interaction displayed a compromised ability to restrict virus entry, supporting the idea of an important role for the RNase L-Filamin A complex in barrier function. Remarkably, both the wild type and a catalytically inactive RNase L mutant were competent to reduce virus entry when transfected into RNase L-deficient cells, indicating that this novel function of RNase L is independent of its enzymatic activity. Virus infection and RNase L activation disrupt its association with Filamin A and release RNase L to mediate its canonical nuclease-dependent antiviral activities. The dual functions of RNase L as a constitutive component of the actin cytoskeleton and as an induced mediator of antiviral signaling and effector functions provide insights into its mechanisms of antiviral activity and opportunities for the development of novel antiviral agents. PMID:25352621

Concerning enactment of regulations on burying of waste of nuclear fuel material or waste contaminated with nuclear fuel material

International Nuclear Information System (INIS)

1988-01-01

The Atomic Safety Commission of Japan, after examining a report submitted by the Science and Technology Agency concerning the enactment of regulations on burying of waste of nuclear fuel material or waste contaminated with nuclear fuel material, has approved the plan given in the report. Thus, laws and regulations concerning procedures for application for waste burying business, technical standards for implementation of waste burying operation, and measures to be taken for security should be established to ensure the following. Matters to be described in the application for the approval of such business and materials to be attached to the application should be stipulated. Technical standards concerning inspection of waste burying operation should be stipulated. Measures to be taken for the security of waste burying facilities and security concerning the transportation and disposal of nuclear fuel material should be stipulated. Matters to be specified in the security rules should be stipulated. Matters to be recorded by waste burying business operators, measures to be taken to overcome dangers and matters to be reported to the Science and Technology Agency should be stipulated. (Nogami, K.)

Assessment of policy issues in nuclear safety regulation according to circumstantial changes

Energy Technology Data Exchange (ETDEWEB)

Chang, Soon Heung; Lee, Byong Ho; Baek, Won Pil; Lee, Kwang Gu; Huh, Gyun Young; Hahn, Young Tae [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

2000-03-15

The objective of the work is to assess various issues in nuclear safety regulation in consideration of circumstantial changes. Emphasis is given to the safety of operating NPPs. It is concluded that the Periodic Safety Review (PSR) should be implemented in Korea as soon as possible, in harmonization with the regulation for life extension of NPPs. The IAEA guidelines, including 10 year intervals and 11 safety factors, should be used as the basic guidelines. The approach to improve regulatory effectiveness is also reviewed and a transition to 'knowledge-based regulation' is suggested.

Decommissioning commercial nuclear facilities: a review and analysis of current regulations

International Nuclear Information System (INIS)

Schilling, A.H.; Lippek, H.E.; Tegeler, P.D.; Easterling, J.D.

1979-08-01

This report describes and analyzes the regulatory requirements and guidelines applicable to the decommissioning of commercial light water reactors, other commercial nuclear fuel cycle facilities, and byproduct utilization facilities, as contained principally in the United States Code, the United States Code of Federal Regulations, and the United States Nuclear Regulatory Commission's Regulatory Guides. State requirements are discussed where appropriate. The report provides general background informaion to license applicants and to other interested parties. Included is an outline of procedural steps required of an applicant to comply with decommissioning regulatory requiremets

Motif analysis unveils the possible co-regulation of chloroplast genes and nuclear genes encoding chloroplast proteins.

Science.gov (United States)

Wang, Ying; Ding, Jun; Daniell, Henry; Hu, Haiyan; Li, Xiaoman

2012-09-01

Chloroplasts play critical roles in land plant cells. Despite their importance and the availability of at least 200 sequenced chloroplast genomes, the number of known DNA regulatory sequences in chloroplast genomes are limited. In this paper, we designed computational methods to systematically study putative DNA regulatory sequences in intergenic regions near chloroplast genes in seven plant species and in promoter sequences of nuclear genes in Arabidopsis and rice. We found that -35/-10 elements alone cannot explain the transcriptional regulation of chloroplast genes. We also concluded that there are unlikely motifs shared by intergenic sequences of most of chloroplast genes, indicating that these genes are regulated differently. Finally and surprisingly, we found five conserved motifs, each of which occurs in no more than six chloroplast intergenic sequences, are significantly shared by promoters of nuclear-genes encoding chloroplast proteins. By integrating information from gene function annotation, protein subcellular localization analyses, protein-protein interaction data, and gene expression data, we further showed support of the functionality of these conserved motifs. Our study implies the existence of unknown nuclear-encoded transcription factors that regulate both chloroplast genes and nuclear genes encoding chloroplast protein, which sheds light on the understanding of the transcriptional regulation of chloroplast genes.

Texting while driving: is speech-based text entry less risky than handheld text entry?

Science.gov (United States)

He, J; Chaparro, A; Nguyen, B; Burge, R J; Crandall, J; Chaparro, B; Ni, R; Cao, S

2014-11-01

Research indicates that using a cell phone to talk or text while maneuvering a vehicle impairs driving performance. However, few published studies directly compare the distracting effects of texting using a hands-free (i.e., speech-based interface) versus handheld cell phone, which is an important issue for legislation, automotive interface design and driving safety training. This study compared the effect of speech-based versus handheld text entries on simulated driving performance by asking participants to perform a car following task while controlling the duration of a secondary text-entry task. Results showed that both speech-based and handheld text entries impaired driving performance relative to the drive-only condition by causing more variation in speed and lane position. Handheld text entry also increased the brake response time and increased variation in headway distance. Text entry using a speech-based cell phone was less detrimental to driving performance than handheld text entry. Nevertheless, the speech-based text entry task still significantly impaired driving compared to the drive-only condition. These results suggest that speech-based text entry disrupts driving, but reduces the level of performance interference compared to text entry with a handheld device. In addition, the difference in the distraction effect caused by speech-based and handheld text entry is not simply due to the difference in task duration. Copyright © 2014 Elsevier Ltd. All rights reserved.

Nuclear regulation in the United States : Policy directions and future prospects

International Nuclear Information System (INIS)

Shirley, Ann Jackson

1996-01-01

Just before leaving the United States to come to Korea, I addressed the U. S. Nuclear Regulatory Commission (NRC) annual regulatory information conference, with which some of you might be familiar. The overall theme this year focused on enhancing and promoting a better understanding of future trends for improving nuclear safety. Specific sessions addressed an array of nuclear safety topics including: dry cask storage of spent fuel; performance-based changes in the inspection program; core performance and reactor fuel issues; the revised decommissioning rule; utility restructuring and NRC licensing activities; steam generators; implementation of the maintenance rule; an update on license renewal; the shutdown rule; and spent fuel pool issues. The number and range of topics addressed tells US that the nuclear field is by no means static. On the contrary. there are numerous areas in which regulatory policy is evolving in response to technological, governmental, and other developments. while not all nations with nuclear programs face the same issues at the same time, there is enough overlap from one nation to another that it may be useful to describe the challenges facing the NRC today. the nuclear regulatory policy is moving. The challenges that we are dealing with at the NRC today may well be those which other nations will be confronting shortly? of they are not doing so already. In addressing the question of my vision for the NRC, I am sometimes asked whether it is possible to have a vision for the agency, given that no new nuclear plants are being built in the U. S. and none are on the immediate horizon. The answer, of course, is that the original licensing of nuclear power plants is only a part of the job of the NRC? an important part, to be sure, be but because safety must be built into nuclear plants from the beginning -- but nevertheless just one part. The task of the nuclear regulator is to ensure not only that plants are designed and constructed safely, but

Lessons learned from application of the Swedish regulations for decommissioning of nuclear facilities - The regulator's perspective

International Nuclear Information System (INIS)

Efraimsson, Henrik; Amft, Martin; Leisvik, Mathias

2016-01-01

The paper presents an overview of the Swedish regulations for decommissioning of nuclear facilities. It describes some of the experiences that the Swedish Radiation Safety Authority has gained from the application of these regulations. The focus of the present paper lies on administrative aspects of the care and maintenance operation and on the safety related documentation that has to be prepared before dismantling commences. Lessons learned during recent years will be considered when revising the regulations for decommissioning. Also these lessons learned will help to streamline the administration of the large NPP decommissioning projects that are anticipated to commence in Sweden in the near future. (authors)

An international comparison of commercial nuclear power plant staffing regulations and practice, 1980--1990

International Nuclear Information System (INIS)

Melber, B.; Hauth, J.; Terrill, E.; Berk, B.; Gore, B.

1994-03-01

In this report an international review of regulatory and industry practices is provided in the area of nuclear power plant staffing during the 1980s in Canada, France, Germany, Japan, Sweden, and the United Kingdom. The objective of this review is to highlight trends in staffing regulatory approaches, industry practices, and issues of concern in other countries that have potential relevance to nuclear power plant staffing issues in the United States. The decade of the 1980s was marked by a great deal of growth in nuclear power operations internationally; however, growth of nuclear power is not expected to continue in the 1990s except in France and Japan. A continuum of regulatory approaches to staffing was identified, ranging from prescribed regulations that are applied to all licensees (Germany is most similar to the United States in this regard), to indirect staffing regulations where the regulatory authority oversees plant operating practices that are agreed to in the plant operating license (most notably, France and the United Kingdom). Most of the changes observed in staffing regulations and practices in the early 1980s were made in response to the accident at the Three Mile Island Unit 2 nuclear power plant (TMI) in 1979. These changes included the widespread issuance of new operator and licensing requirements and the establishment of national training centers. After the post-TMI changes were implemented, a period of relative stability followed. Changes in the latter half of the 1980s have focused on continuing improvements and additions to training curricula and methods, most notably increased reliance on simulator training

Recent development in safety regulation of nuclear fuel cycle activities

International Nuclear Information System (INIS)

Kato, S.

2001-01-01

Through the effort of deliberation and legislation over five years, Japanese government structure was reformed this January, with the aim of realizing simple, efficient and transparent administration. Under the reform, the Agency for Nuclear and Industrial Safety (ANIS) was founded in the Ministry of Economy, Trade and Industry (METI) to be responsible for safety regulation of energy-related nuclear activities, including nuclear fuel cycle activities, and industrial activities, including explosives, high-pressure gasses and mining. As one of the lessons learned from the JCO criticality accident of September 1999, it was pointed out that the government's inspection function was not enough for fuel fabrication facilities. Accordingly, new statutory regulatory activities were introduced, namely, inspection of observance of safety rules and procedures for all kinds of nuclear operators and periodic inspection of fuel fabrication facilities. In addition, in order to cope with insufficient safety education and training of workers in nuclear facilities, licensees of nuclear facilities are required by law to specify safety education and training for their workers. ANIS is committed to enforce these new regulatory activities effectively and efficiently. In addition, it is going to be prepared, in its capacity as safety regulatory authority, for future development of Japanese fuel cycle activities, including commissioning of JNFL Rokkasho reprocessing plant and possible application for licenses for JNFL MOX fabrication plant and for spent fuel interim storage facilities. (author)

The Regulation of Major Risks in Relation to Large Nuclear Installations in France

International Nuclear Information System (INIS)

Phan Van, L.

1991-01-01

Recently, major risk prevention has generated legislative and regulatory texts in French law, particularly regarding nuclear installations. This article reviews the context and analyses the scope of the new regulations. They require the nuclear operator to take preventive measures, namely more stringent obligations from the safety viewpoint to inform the public. These include risk assessments and preparing emergency plans in case if accidents. (NEA)

7 CFR 319.41-1 - Plant products permitted entry. 1

Science.gov (United States)

2010-01-01

... risk is involved in their entry. (3) Corn silk. (b) Upon compliance with the regulations in this... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Indian Corn or Maize, Broomcorn, and... countries. (§ 319.15.) (b) Except as provided for in paragraph (c) for corn seed from New Zealand, seed and...

Non-power application as an entry point to nuclear power program

International Nuclear Information System (INIS)

Nahrul Khair Alang Md Rashid

2009-01-01

Nuclear power is usually viewed as the flagship of nuclear technology. A nuclear power plant complex, visible and prominence, is iconic of the technology. That image makes its presence common knowledge to the extent that nuclear technology is equated almost totally with nuclear power by the general public. The downside of this visibility is that it becomes easy target in public misinformation programs. The non-power applications however are not visible, and devoid of icon. The non-power applications, therefore, can grow quite smoothly, attracting only little attention in the negative and in the positive senses. According to a study conducted in the USA in 2000 and in Japan in 2002, the socio-economic impact of non-power and power applications of nuclear technology are comparable. Involvement in non-power applications can be a good grounding for moving into power applications. This paper discusses the non-power nuclear technology applications and in what manner it can serve to prepare the introduction of nuclear power program. (Author)

The Impact of Environmental Taxes on Firm’s Technology and Entry Decisions

OpenAIRE

Ana Espinola-Arredondo; Boying Liu

2014-01-01

This paper investigates conditions under which the regulator can strate- gically set an emission fee as a tool to induce Örms to adopt a green tech- nology and, also, promote (or hinder) entry deterrence. We consider a market in which a monopolistic incumbent faces the threat of entry, and Örms can choose between a dirty and a green technology. Our results show that, despite the fact of facing a polluting incumbent, an entrant might Önd it proÖtable to join the market and acquire a clean tech...

Framework for applying probabilistic safety analysis in nuclear regulation

International Nuclear Information System (INIS)

Dimitrijevic, V.B.

1997-01-01

The traditional regulatory framework has served well to assure the protection of public health and safety. It has been recognized, however, that in a few circumstances, this deterministic framework has lead to an extensive expenditure on matters hat have little to do with the safe and reliable operation of the plant. Developments of plant-specific PSA have offered a new and powerful analytical tool in the evaluation of the safety of the plant. Using PSA insights as an aid to decision making in the regulatory process is now known as 'risk-based' or 'risk-informed' regulation. Numerous activities in the U.S. nuclear industry are focusing on applying this new approach to modify regulatory requirements. In addition, other approaches to regulations are in the developmental phase and are being evaluated. One is based on the performance monitoring and results and it is known as performance-based regulation. The other, called the blended approach, combines traditional deterministic principles with PSA insights and performance results. (author)

9 CFR 381.199 - Inspection of poultry products offered for entry.

Science.gov (United States)

2010-01-01

... AND VOLUNTARY INSPECTION AND CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Imported Poultry... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Inspection of poultry products offered for entry. 381.199 Section 381.199 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE...

Promoting nuclear energy: market price or regulated tariffs? - 5042

International Nuclear Information System (INIS)

Percebois, J.

2015-01-01

Because of its negative effects, the scheme for aiding renewable energies presently in force in Europe is likely to penalise investments in nuclear energy. The F.I.T. system is a costly mechanism and a source of perverse effects as a switching of the merit order curve on the spot electricity market (with sometimes negative prices). Restoring an equity and 'equal opportunity' for nuclear energy in Europe needs to implement a 'Contract for Differences' scheme for nuclear energy, like the model now gaining favour in the U.K. The contract for differences signed between EDF and the UK government means that if the wholesale price that EDF secures for Hinckley's power falls below the index-linked preset value, the difference will be covered by payments from the UK government. It appears that nuclear power has weakened in Europe by the system of guaranteed purchase prices for renewable energies. Moreover this system is costly. New fairer rules must be implemented in the market. Either the market is left on its own to send the signals to all investors (including renewable energies), or a minimum of regulation is introduced in order to limit the costly surges of under and over capacity. But in the latter case it is necessary to treat all the energy sources in an equal way and guarantee the nuclear industry that it will also recover its fixed costs over the long term)

Experiences in certification of packages for transportation of fresh nuclear fuel in the context of new safety requirements established by IAEA regulations (IAEA-96 regulations, ST-1) for air transportation of nuclear materials (requirements to C-type packages)

Energy Technology Data Exchange (ETDEWEB)

Dudai, V.I.; Kovtun, A.D.; Matveev, V.Z.; Morenko, A.I.; Nilulin, V.M.; Shapovalov, V.I.; Yakushev, V.A.; Bobrovsky, V.S.; Rozhkov, V.V.; Agapov, A.M.; Kolesnikov, A.S. [Russian Federal Nuclear Centre - All-Russian Research Inst. of Experimental Physics, Sarov (Russian Federation)]|[JSC ' ' MSZ' ' , Electrostal (Russian Federation)]|[JSC ' ' NPCC' ' , Novosibirsk (Russian Federation)]|[Minatom of Russia, Moscow (Russian Federation)]|[Gosatomnadzor of Russia, Moscow (Russian Federation)

2004-07-01

Every year in Russia, a large amount of domestic and international transportation of fresh nuclear fuel (FNF) used in Russian and foreign energy and research atomic reactors and referred to fissile materials based on IAEA Regulations is performed. Here, bulk transportation is performed by air, and it concerns international transportation in particular. According to national ''Main Regulations for Safe Transport and physical Protection of Nuclear Materials (OPBZ- 83)'' and ''Regulations for the Safe Transport of Radioactive Materials'' of the International Atomic Energy Agency (IAEA Regulations), nuclear and radiation security under normal (accident free) and accident conditions of transport must be completely provided by the package design. In this context, high requirements to fissile packages exposed to heat and mechanical loads in transport accidents are imposed. A long-standing experience in accident free transportation of FM has shown that such approach to provide nuclear and radiation security pays for itself completely. Nevertheless, once in 10 years the International Atomic Energy Agency on every revision of the ''Regulations for the Safe Transport of Radioactive Materials'' places more stringent requirements upon the FM and transportation thereof, resulting from the objectively increasing risk associated with constant rise in volume and density of transportation, and also strained social and economical situation in a number of regions in the world. In the new edition of the IAEA Regulations (ST-1), published in 1996 and brought into force in 2001 (IAEA-96 Regulations), the requirements to FM packages conveyed by aircraft were radically changed. These requirements are completely presented in new Russian ''Regulations for the Safe Transport of Radioactive Materials'' (PBTRM- 2004) which will be brought into force in the time ahead.

9 CFR 381.203 - Products offered for entry; charges for storage, cartage, and labor with respect to products...

Science.gov (United States)

2010-01-01

... CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Imported Poultry Products § 381.203 Products offered for... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Products offered for entry; charges for storage, cartage, and labor with respect to products which are refused entry. 381.203 Section 381...

A Human Nuclear Shuttling Protein That Interacts with Human Immunodeficiency Virus Type 1 Matrix Is Packaged into Virions

Science.gov (United States)

Gupta, Kalpana; Ott, David; Hope, Thomas J.; Siliciano, Robert F.; Boeke, Jef D.

2000-01-01

Active nuclear import of the human immunodeficiency virus type 1 (HIV-1) preintegration complex (PIC) is essential for the productive infection of nondividing cells. Nuclear import of the PIC is mediated by the HIV-1 matrix protein, which also plays several critical roles during viral entry and possibly during virion production facilitating the export of Pr55Gag and genomic RNA. Using a yeast two-hybrid screen, we identified a novel human virion-associated matrix-interacting protein (VAN) that is highly conserved in vertebrates and expressed in most human tissues. Its expression is upregulated upon activation of CD4+ T cells. VAN is efficiently incorporated into HIV-1 virions and, like matrix, shuttles between the nucleus and cytoplasm. Furthermore, overexpression of VAN significantly inhibits HIV-1 replication in tissue culture. We propose that VAN regulates matrix nuclear localization and, by extension, both nuclear import of the PIC and export of Pr55Gag and viral genomic RNA during virion production. Our data suggest that this regulatory mechanism reflects a more global process for regulation of nucleocytoplasmic transport. PMID:11090181

Border Crossing/Entry Data - Border Crossing/Entry Data Time Series tool

Data.gov (United States)

Department of Transportation — The dataset is known as “Border Crossing/Entry Data.” The Bureau of Transportation Statistics (BTS) Border Crossing/Entry Data provides summary statistics to the...

Double entry bookkeeping vs single entry bookkeeping

Directory of Open Access Journals (Sweden)

Ileana Andreica

2016-11-01

Full Text Available Abstract: A financial management eficiently begin, primarily, with an accounting record kept in the best possible conditions, this being conditioned on the adoption of a uniform forms, rational, clear and simple accounting. Throughout history, there have been known two forms of accounting: the simple and double entry. Romanian society after 1990 underwent a substantial change in social structure, the sector on which put a great emphasis being private, that of small manufacturers, peddler, freelance, who work independently and authorized or as associative form (family enterprises, various associations (owners, tenants, etc., liberal professions, etc.. They are obliged to keep a simple bookkeeping, because they have no juridical personality. Companies with legal personality are required to keep double entry bookkeeping; therefore, knowledge and border demarcation between the two forms of organisation of accounting is an essential. The material used for this work is mainly represented by the financial and accounting documents, by the analysis of the economic, by legislative updated sources, and as the method was used the comparison method, using hypothetical data, in case of an authorized individual and a legal entity. Based on the chosen material, an authorized individual (who perform single entry accounting system and a juridical entity (who perform double entry accounting system were selected comparative case studies, using hypothetical data, were analysed advantages and disadvantages in term of fiscal, if using two accounting systems, then were highlighted some conclusion that result.

A comparison between regulation of nuclear power in Canada and the United States

International Nuclear Information System (INIS)

Ahearne, J.F.

1988-01-01

The agencies that regulate commercial nuclear power in Canada and the United States differ in five significant characteristics: size and responsibility; use of legalism and formality; inspection and enforcement approaches; relationships to the government, public and industry; and the basic philosophy of regulation. Examination shows strengths and weaknesses in each approach, tied to basic differences in philosophy of government. (author)

Foreign market entry strategies in developed and emerging economies: A case study of how the entry strategies of Norwegian oil service firms are affected by the differing institutional contexts of Australia and Brazil

OpenAIRE

Arnstorp, Henrik

2013-01-01

When firms expand to foreign markets, their entry strategies unfold. Traditionally, research on entry strategies has focused exclusively on firm- and industry-specific factors and largely ignored the context constituted by the institutions of the host country. The institutional context determines the ?rules of the game? in any market, and includes both formal institutions such as laws and regulations and informal institutions such as norms and culture. With the increasing relevance of emergin...

Fixes regulations for application of dispositives of the Law 4,118 (as of August 27, 1962), and its regulation approved by the Decree 51,726 (as of February 19, 1963) referred to the nuclear minerals, ores and of interest for nuclear energy

International Nuclear Information System (INIS)

1965-01-01

The present resolution establishes regulations for provision of the Law 4118 (dated of August 27, 1962) and his regulation a proved by Decree 51,726 (dated of February 19, 1963) as referring to the minerals, nuclear ores and of interest for the nuclear energy, substituting the Resolution 1/63

Proposal of guidelines for structuring an independent regulation body for the Brazilian nuclear sector

International Nuclear Information System (INIS)

Nicoll Junior, Ricardo

2016-01-01

Regulatory bodies are responsible for regulation in various sectors of society. In Brazil, they work in various areas for the development of the country and have as main objective the social, economic and national development. The progress of new technologies in the nuclear field and their commercialization underscores the need for regulation according to international safety standards. The present research searches through an extensive review of the literature identify the international guidelines for regulatory bodies and make a comparative analysis between Brazil and five countries that have independent regulatory bodies in the nuclear sector. The purpose of the work is to contribute to the Brazilian public sectors, with an evaluation of the country's regulation in the perception of specialists and propose guidelines for the structuring of an independent regulatory body, respecting international agreements and the legislation in force in the country. (author)

Regulation of behaviour by the nuclear receptor TLX.

Science.gov (United States)

O'Leary, J D; O'Leary, O F; Cryan, J F; Nolan, Y M

2018-03-01

The orphan nuclear receptor Tlx (Nr2e1) is a key regulator of both embryonic and adult hippocampal neurogenesis. Several different mouse models have been developed which target Tlx in vivo including spontaneous deletion models (from birth) and targeted and conditional knockouts. Although some conflicting findings have been reported, for the most part studies have demonstrated that Tlx is important in regulating processes that underlie neurogenesis, spatial learning, anxiety-like behaviour and interestingly, aggression. More recent data have demonstrated that disrupting Tlx during early life induces hyperactivity and that Tlx plays a role in emotional regulation. Moreover, there are sex- and age-related differences in some behaviours in Tlx knockout mice during adolescence and adulthood. Here, we discuss the role of Tlx in motor-, cognitive-, aggressive- and anxiety-related behaviours during adolescence and adulthood. We examine current evidence which provides insight into Tlx during neurodevelopment, and offer our thoughts on the function of Tlx in brain and behaviour. We further hypothesize that Tlx is a key target in understanding the emergence of neurobiological disorders during adolescence and early adulthood. © 2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.

State regulation of nuclear sector: comparative study of Argentina and Brazil models; Regulacao estatal do setor nuclear: estudo comparativo dos modelos da Argentina e do Brasil

Energy Technology Data Exchange (ETDEWEB)

Monteiro Filho, Joselio Silveira

2004-08-01

This research presents a comparative assessment of the regulation models of the nuclear sector in Argentina - under the responsibility of the Autoridad Regulatoria Nuclear (ARN), and Brazil - under the responsibility of Comissao Nacional de Energia Nuclear (CNEN), trying to identify which model is more adequate aiming the safe use of nuclear energy. Due to the methodology adopted, the theoretical framework resulted in criteria of analysis that corresponds to the characteristics of the Brazilian regulatory agencies created for other economic sector during the State reform staring in the middle of the nineties. Later, these criteria of analysis were used as comparison patterns between the regulation models of the nuclear sectors of Argentina and Brazil. The comparative assessment showed that the regulatory structure of the nuclear sector in Argentina seems to be more adequate, concerning the safe use of nuclear energy, than the model adopted in Brazil by CNEN, because its incorporates the criteria of functional, institutional and financial independence, competence definitions, technical excellence and transparency, indispensable to the development of its functions with autonomy, ethics, exemption and agility. (author)

Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes.

Science.gov (United States)

Riepsamen, Angelique; Wu, Lindsay; Lau, Laurin; Listijono, Dave; Ledger, William; Sinclair, David; Homer, Hayden

2015-01-01

Following exit from meiosis I, mammalian oocytes immediately enter meiosis II without an intervening interphase, accompanied by rapid reassembly of a bipolar spindle that maintains condensed chromosomes in a metaphase configuration (metaphase II arrest). Here we study the effect of nicotinamide (NAM), a non-competitive pan-sirtuin inhibitor, during meiotic maturation in mouse oocytes. Sirtuins are a family of seven NAD+-dependent deacetylases (Sirt1-7), which are involved in multiple cellular processes and are emerging as important regulators in oocytes and embryos. We found that NAM significantly delayed entry into meiosis I associated with delayed accumulation of the Cdk1 co-activator, cyclin B1. GVBD was also inhibited by the Sirt2-specific inhibitor, AGK2, and in a very similar pattern to NAM, supporting the notion that as in somatic cells, NAM inhibits sirtuins in oocytes. NAM did not affect subsequent spindle assembly, chromosome alignment or the timing of first polar body extrusion (PBE). Unexpectedly, however, in the majority of oocytes with a polar body, chromatin was decondensed and a nuclear structure was present. An identical phenotype was observed when flavopiridol was used to induce Cdk1 inactivation during late meiosis I prior to PBE, but not if Cdk1 was inactivated after PBE when metaphase II arrest was already established, altogether indicating that NAM impaired establishment rather than maintenance of metaphase II arrest. During meiosis I exit in NAM-treated medium, we found that cyclin B1 levels were lower and inhibitory Cdk1 phosphorylation was increased compared with controls. Although activation of the anaphase-promoting complex-Cdc20 (APC-Cdc20) occurred on-time in NAM-treated oocytes, Cdc20 levels were higher in very late meiosis I, pointing to exaggerated APC-Cdc20-mediated proteolysis as a reason for lower cyclin B1 levels. Collectively, therefore, our data indicate that by disrupting Cdk1 regulation, NAM impairs entry into meiosis I and

A study on environmental regulation and public inquiry system of nuclear facilities

International Nuclear Information System (INIS)

Lee, Sang Hun; Kang, Chang Sun; Son, Ki Yon; Cho, Young Ho; Yang, Ji Won; Lee, Young Wook; Ko, Hyun Suk

2000-03-01

Public hearing system for domestic and foreign nuclear facilities are investigated and analyzed. As a result, Korean public hearing system are developed. Atomic Energy Act, Environmental Impact Assessment Act and Administrative Procedure Act of Korea are reviewed and appropriate acts, regulations, procedures and mandates of foreign countries including U.S.A are reviewed and analyzed. On the basis of these results the role of device to collect public opinion is identified for nuclear facility of Korea and the elementary principle of the system and recommendations are developed

A study on environmental regulation and public inquiry system of nuclear facilities

Energy Technology Data Exchange (ETDEWEB)

Lee, Sang Hun [Korea Association for Nuclear Technology, Taejon (Korea, Republic of); Kang, Chang Sun; Son, Ki Yon; Cho, Young Ho; Yang, Ji Won; Lee, Young Wook; Ko, Hyun Suk [Seoul National Univ., Seoul (Korea, Republic of)

2000-03-15

Public hearing system for domestic and foreign nuclear facilities are investigated and analyzed. As a result, Korean public hearing system are developed. Atomic Energy Act, Environmental Impact Assessment Act and Administrative Procedure Act of Korea are reviewed and appropriate acts, regulations, procedures and mandates of foreign countries including U.S.A are reviewed and analyzed. On the basis of these results the role of device to collect public opinion is identified for nuclear facility of Korea and the elementary principle of the system and recommendations are developed.

Underground nuclear power station using self-regulating heat-pipe controlled reactors

International Nuclear Information System (INIS)

Hampel, V.E.

1989-01-01

The author presents a nuclear reactor for generating electricity disposed underground at the bottom of a vertical hole that can be drilled using conventional drilling technology. The primary coolant of the reactor core is the working fluid in a plurality of thermodynamically coupled heat pipes emplaced in the hole between the heat source at the bottom of the hole and heat exchange means near the surface of the earth. Additionally, the primary coolant (consisting of the working fluid in the heat pipes in the reactor core) moderates neutrons and regulates their reactivity, thus keeping the power of the reactor substantially constant. At the end of its useful life, the reactor core may be abandoned in place. Isolation from the atmosphere in case of accident or for abandonment is provided by the operation of explosive closures and mechanical valves emplaced along the hole. This invention combines technology developed and tested for small, highly efficient, space-based nuclear electric power plants with the technology of fast-acting closure mechanisms developed and used for underground testing of nuclear weapons. This invention provides a nuclear power installation which is safe from the worst conceivable reactor accident, namely, the explosion of a nuclear weapon near the ground surface of a nuclear power reactor

Underground nuclear power station using self-regulating heat-pipe controlled reactors

Science.gov (United States)

Hampel, Viktor E.

1989-01-01

A nuclear reactor for generating electricity is disposed underground at the bottom of a vertical hole that can be drilled using conventional drilling technology. The primary coolant of the reactor core is the working fluid in a plurality of thermodynamically coupled heat pipes emplaced in the hole between the heat source at the bottom of the hole and heat exchange means near the surface of the earth. Additionally, the primary coolant (consisting of the working flud in the heat pipes in the reactor core) moderates neutrons and regulates their reactivity, thus keeping the power of the reactor substantially constant. At the end of its useful life, the reactor core may be abandoned in place. Isolation from the atmosphere in case of accident or for abandonment is provided by the operation of explosive closures and mechanical valves emplaced along the hole. This invention combines technology developed and tested for small, highly efficient, space-based nuclear electric power plants with the technology of fast-acting closure mechanisms developed and used for underground testing of nuclear weapons. This invention provides a nuclear power installation which is safe from the worst conceivable reactor accident, namely, the explosion of a nuclear weapon near the ground surface of a nuclear power reactor.

Class notes from the first international training course on the physical protection of nuclear facilities and materials

Energy Technology Data Exchange (ETDEWEB)

Herrington, P.B. (ed.)

1979-05-01

The International Training Course on Physical Protection of Nuclear Facilities and Materials was intended for representatives from the developing countries who are responsible for preparing regulations and designing and assessing physical protection systems. The first part of the course consists of lectures on the objectives, organizational characteristics, and licensing and regulations requirements of a state system of physical protection. Since the participants may have little experience in nuclear energy, background information is provided on the topics of nuclear materials, radiation hazards, reactor systems, and reactor operations. Transportation of nuclear materials is addressed and emphasis is placed on regulations. Included in these discussions are presentations by guest speakers from countries outside the United States of America who present their countries' threat to nuclear facilities. Effectiveness evaluation methodology is introduced to the participants by means of instructions which teach them how to use logic trees and the EASI (Estimate of Adversary Sequence Interruption) program. The following elements of a physical protection system are discussed: barriers, protective force, intrusion detection systems, communications, and entry-control systems. Total systems concepts of physical protection system design are emphasized throughout the course. Costs, manpower/technology trade-offs, and other practical considerations are discussed. Approximately one-third of the course is devoted to practical exercises during which the attendees participatein problem solving. A hypothetical nuclear facility is introduced, and the attendees participate in the conceptual design of a physical protection system for the facility.

Class notes from the first international training course on the physical protection of nuclear facilities and materials

International Nuclear Information System (INIS)

Herrington, P.B.

1979-05-01

The International Training Course on Physical Protection of Nuclear Facilities and Materials was intended for representatives from the developing countries who are responsible for preparing regulations and designing and assessing physical protection systems. The first part of the course consists of lectures on the objectives, organizational characteristics, and licensing and regulations requirements of a state system of physical protection. Since the participants may have little experience in nuclear energy, background information is provided on the topics of nuclear materials, radiation hazards, reactor systems, and reactor operations. Transportation of nuclear materials is addressed and emphasis is placed on regulations. Included in these discussions are presentations by guest speakers from countries outside the United States of America who present their countries' threat to nuclear facilities. Effectiveness evaluation methodology is introduced to the participants by means of instructions which teach them how to use logic trees and the EASI (Estimate of Adversary Sequence Interruption) program. The following elements of a physical protection system are discussed: barriers, protective force, intrusion detection systems, communications, and entry-control systems. Total systems concepts of physical protection system design are emphasized throughout the course. Costs, manpower/technology trade-offs, and other practical considerations are discussed. Approximately one-third of the course is devoted to practical exercises during which the attendees participatein problem solving. A hypothetical nuclear facility is introduced, and the attendees participate in the conceptual design of a physical protection system for the facility

Challenges for nuclear regulators

International Nuclear Information System (INIS)

Allen, M.R.

1994-01-01

The paper discusses issues that will present particular challenges to the nuclear industry, during the next decade, that should be addressed in order to achieve increased public acceptance of the industry. The issues of safety culture, peer review of safety, severe accidents, transport accidents and public communication are suggest as meriting special consideration. The need for nuclear regulatory agencies to establish credibility and for operating organisations to demonstrate accountability is emphasised, and the Australian experiences are reviewed. Increased collaboration by nuclear regulatory agencies in the Asian-pacific region is suggested, in order to encourage consistency of regulatory safety standards for the nuclear safety issues identified. Methods whereby this could be achieved within the framework of existing agreements and arrangements are suggested. 2 refs

Nuclear safety philosophy and its general application to fuel management and handling - a regulator's viewpoint

International Nuclear Information System (INIS)

Petty, I.C.

1995-01-01

The Nuclear Safety Division (NSD) of the Health and Safety Executive (HSE) informs the UK Nuclear Industry of the principles that it applies in assessing whether licensees have demonstrated that their nuclear plants are as safe as is reasonably practicable. The paper commences with a discussion of the non-prescriptive approach to health and safety regulation which is the basis of the regulatory activities of NSD's operating arm -the Nuclear Installations Inspectorate (NII). It then describes in broad terms the overall approach used by NII for analysing the safety of nuclear plant, including fuel, which will cover both deterministic and probabilistic methodologies. The paper then introduces the sections of the Safety Assessment Principles which apply to nuclear fuel safety (both fuel handling and management). Most of these principles are of a general nature and do not just apply to fuel. The paper explains how safety cases might relate to the SAPs and offers some views on how a licensee might interpret them in developing his safety case. Particular emphasis is placed on the importance of submitting a high quality safety case and the type of information that should be in it. The advantages of the approach proposed, to the licensee as well as to the regulator, are identified. (author)

32 CFR 552.35 - Rights-of-entry for survey and exploration.

Science.gov (United States)

2010-07-01

... RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Acquisition of Real Estate and... to enter upon non-Government-owned real estate during site selection, particularly for the purpose of... 32 National Defense 3 2010-07-01 2010-07-01 true Rights-of-entry for survey and exploration. 552...

Physical protection of nuclear materials: Experience in regulation, implementation and operations. Proceedings of a conference

International Nuclear Information System (INIS)

1998-01-01

The conference was held at IAEA Headquarters in Vienna from 10 to 14 November 1997. It was attended by 162 registered participants from 42 countries and eight international organizations. The 58 papers presented dealt with the experience of regulators, designers and facility operators, including response forces, in meeting the demands and requirements in this changing area of physical protection of nuclear materials and facilities. Individual abstracts were prepared for each of the papers. Topics covered include contemporary and emerging issues, experience in regulation, implementation at facilities, program assessment and cooperation, hardware and software, illicit trafficking in nuclear materials, and transportation

Proposed nuclear weapons nonproliferation policy concerning foreign research reactor spent nuclear fuel: Appendix A, environmental justice analysis. Volume 2

International Nuclear Information System (INIS)

1995-03-01

This is Appendix A to a draft Environmental Impact Statement on a Proposed Nuclear Weapons Nonproliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel. This appendix addresses environmental justice for the acceptance of foreign research reactor spent nuclear fuel containing uranium enriched in the United States. Analyses of environmental justice concerns are provided in three areas: (1) potential ports of entry, (2) potential transportation routes from candidate ports of entry to interim management sites, and (3) areas surrounding potential interim management sites. These analyses lead to the conclusion that the alternatives analyzed in this Environmental Impact Statement (EIS) would result in no disproportionate adverse effects on minority populations or low-income communities surrounding the candidate ports, transport routes, or interim management sites

Jesus' Entry into Jerusalem

Directory of Open Access Journals (Sweden)

Juho Sankamo

2014-12-01

Full Text Available This article intends to contribute to the understanding of Jesus’ entry into Jerusalem. The author studies the entry, which is found in all the Gospels, in its Jewish context. The author argues that Jesus’ entry into Jerusalem on an ass is to be understood as a prophetic sign which was primarily meant to convey a message to the Jews.

Membrane Anchoring and Ion-Entry Dynamics in P-type ATPase Copper Transport

DEFF Research Database (Denmark)

Grønberg, Christina; Sitsel, Oleg; Lindahl, Erik

2016-01-01

Cu(+)-specific P-type ATPase membrane protein transporters regulate cellular copper levels. The lack of crystal structures in Cu(+)-binding states has limited our understanding of how ion entry and binding are achieved. Here, we characterize the molecular basis of Cu(+) entry using molecular-dynamics...... simulations, structural modeling, and in vitro and in vivo functional assays. Protein structural rearrangements resulting in the exposure of positive charges to bulk solvent rather than to lipid phosphates indicate a direct molecular role of the putative docking platform in Cu(+) delivery. Mutational analyses...... and simulations in the presence and absence of Cu(+) predict that the ion-entry path involves two ion-binding sites: one transient Met148-Cys382 site and one intramembranous site formed by trigonal coordination to Cys384, Asn689, and Met717. The results reconcile earlier biochemical and x-ray absorption data...

Instructions for preparation of data entry sheets for Licensee Event Report (LER) file. Revision 1. Instruction manual

International Nuclear Information System (INIS)

1977-07-01

The manual provides instructions for the preparation of data entry sheets for the licensee event report (LER) file. It is a revision to an interim manual published in October 1974 in 00E-SS-001. The LER file is a computer-based data bank of information using the data entry sheets as input. These data entry sheets contain pertinent information in regard to those occurrences required to be reported to the NRC. The computer-based data bank provides a centralized source of data that may be used for qualitative assessment of the nature and extent of off-normal events in the nuclear industry and as an index of source information to which users may refer for more detail

Incentive regulation of nuclear power plants by state public utility commissions

International Nuclear Information System (INIS)

Petersen, J.C.

1987-12-01

This report on incentive regulation of nuclear power plants by state public utility commissions (PUCs). Economic performance incentives established by state PUCs are applicable to the construction or operation of about 45 nuclear power reactors owned by 30 utilities in 17 states. The NRC staff monitors development of the incentives and periodically provides an updated report on all nuclear plant incentives to its regional offices. The staff maintains contact with the PUCs and the utilities responsible for implementing the incentives in order to obtain the updated information and to consider potential safety effects of the incentives. This report presents the NRC staff's concerns on potential safety effects of economic performance incentives. It also includes a plant-by-plant survey that describes the mechanics of each incentive and discusses the financial effects of the incentive on the utility-owner(s) of the plant

Assessment of policy issues in nuclear safety regulation according to circumstantial changes

Energy Technology Data Exchange (ETDEWEB)

Chang, Soon Heung; Lee, Byong Ho; Baek, Woon Pil; Lee, Seong Wook; Choi, Seong Soo; Roh, Chang Hyun; Lee, Kwang Gu [Korea Advanced Institute of Scienc and Technology, Taejon (Korea, Republic of)

1998-03-15

The objective of the work is to assess various issues in nuclear safety regulation in consideration of circumstantial changes. Emphasis is given to the safety of operating NPPs. The derivation of an effective regulation system considering 'Rhodic Safety Review (PSR)', 'operating License Renewal (LR)', 'backfitting' and 'maintenance rule' is the main objective of the first two years. It is found that those approaches should be introduced in Korea as soon as possible, with cross lingkage to maximize the effectiveness of regulation. In particular, the approaches for PSR are discussed with consultation of IAEA document and foreign practices.

DMPD: Nuclear factor-kappaB: activation and regulation during toll-like receptorsignaling. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 17349209 Nuclear factor-kappaB: activation and regulation during toll-like receptorsignaling. Carmody...uclear factor-kappaB: activation and regulation during toll-like receptorsignaling. Authors Carmody

Protein tyrosine phosphatase-1B (PTP1B) helps regulate EGF-induced stimulation of S-phase entry in human corneal endothelial cells

Science.gov (United States)

Ishino, Yutaka; Zhu, Cheng; Harris, Deshea L.

2008-01-01

Purpose Human corneal endothelial cells (HCEC), particularly from older donors, only proliferate weakly in response to EGF. The protein tyrosine phosphatase, PTP1B, is known to negatively regulate EGF-induced signaling in several cell types by dephosphorylating the epidermal growth factor receptor (EGFR). The current studies were conducted to determine whether PTP1B plays a role in regulating cell cycle entry in HCEC in response to EGF stimulation. Methods Donor corneas were obtained from the National Disease Research Interchange and accepted for study based on established exclusion criteria. PTP1B was localized in the endothelium of ex vivo corneas and in cultured cells by immunocytochemistry. Western blot analysis verified PTP1B protein expression in HCEC and then compared the relative expression of EGFR and PTP1B in HCEC from young (60 years old). The effect of inhibiting the activity of PTP1B on S-phase entry was tested by comparing time-dependent BrdU incorporation in subconfluent HCEC incubated in the presence or absence of the PTP1B inhibitor, CinnGEL 2Me, before EGF stimulation. Results PTP1B was localized in a punctate pattern mainly within the cytoplasm of HCEC in ex vivo corneas and cultured cells. Western blots revealed the presence of three PTP1B-positive bands in HCEC and the control. Further western blot analysis showed no significant age-related difference in expression of EGFR (p=0.444>0.05); however, PTP1B expression was significantly higher in HCEC from older donors (p=0.024<0.05). Pre-incubation of HCEC with the PTP1B inhibitor significantly increased (p=0.019<0.05) the number of BrdU positive cells by 48 h after EGF stimulation. Conclusions Both immunolocalization and western blot studies confirmed that PTP1B is expressed in HCEC. Staining patterns strongly suggest that at least a subset of PTP1B is localized to the cytoplasm and most likely to the endoplasmic reticulum, the known site of EGFR/PTP1B interaction following EGF stimulation. PTP1B

From Hiroshima to nuclear deterrence

International Nuclear Information System (INIS)

Villain, Jacques; Moret, Andre

2015-01-01

The authors first propose an overview of nuclear weapons from their origins to 2014: evolution of weapon systems between 1945 and 2014, main treaties related to nuclear weapons, main consequences of the nuclear revolution, brief presentation and assessment of defences against ballistic missiles, cost of nuclear warfare. The second part proposes a perspective for nuclear weapons in tomorrow's world as it seems that the World will remain nuclear: possible evolution of nuclear proliferation, evolution of risks related to nuclear weapons, desirable and possible evolution of nuclear weapons. Appendices propose presentations of the main techniques used for ballistic missiles: propulsion, control, navigation and guiding, atmosphere re-entry, multiple nuclear heads, data processing, relationship between nuclear plants and weapons

Bases of updating of nuclear safety regulations for NPP in Romania

International Nuclear Information System (INIS)

Biro, Lucian; Serbanescu, Dan

1999-01-01

The paper presents the basic principles of reviewing and updating process of the regulatory environment pyramid. The main part of this review process refers to Cernavoda NPP Unit 2. However, there is an important impact on Cernavoda NPP Unit 1. The basic principles were defined in 1993/1994 when the licensing process for Unit 1 was resumed in order to be in accordance with the latest developments of Candu 600 worldwide and with the IAEA and NEA latest recommended documents and practices. After the licensing process for the Unit 1 was completed up to operation stage, CNCAN developed new updated regulations on nuclear safety and the regulatory pyramid in the framework of the RAMG PHARE project. CNCAN issued in 1996 the regulatory Policy for Unit 2, self-sustained and independent of future possible revisions of the regulations. The use of the concept of hierarchical systems, systematic review of safety criteria and objectives and margins along with the feedback from international and national experience on this topic ensured issuance of a reference document for future approach of nuclear safety in Romania. (authors)

Control of Nuclear Materials and Special Equipment (Nuclear Safety Regulations)

International Nuclear Information System (INIS)

Cizmek, A.; Prah, M.; Medakovic, S.; Ilijas, B.

2008-01-01

Based on Nuclear Safety Act (OG 173/03) the State Office for Nuclear Safety (SONS) in 2008 adopted beside Ordinance on performing nuclear activities (OG 74/06) and Ordinance on special conditions for individual activities to be performed by expert organizations which perform activities in the area of nuclear safety (OG 74/06) the new Ordinance on the control of nuclear material and special equipment (OG 15/08). Ordinance on the control of nuclear material and special equipment lays down the list of nuclear materials and special equipment as well as of nuclear activities covered by the system of control of production of special equipment and non-nuclear material, the procedure for notifying the intention to and filing the application for a license to carry out nuclear activities, and the format and contents of the forms for doing so. This Ordinance also lays down the manner in which nuclear material records have to be kept, the procedure for notifying the State administration organization (regulatory body) responsible for nuclear safety by the nuclear material user, and the keeping of registers of nuclear activities, nuclear material and special equipment by the State administration organization (regulatory body) responsible for nuclear safety, as well as the form and content of official nuclear safety inspector identification card and badge.(author)

Decree 234/003. Is derogate decree 317/987, from the date of entry into force the safe exercise regulation of the packing activities and the distribution of liquefied petroleum gas (LPG) that will dictate the URSEA

International Nuclear Information System (INIS)

2003-01-01

This decree allows the entry into force the safe exercise regulation of the packing activities and the distribution of liquefied petroleum gas (LPG) that will dictate the URSEA (The regulatory unit of energy and water service)

Phosphorylation of zona occludens-2 by protein kinase C epsilon regulates its nuclear exportation.

Science.gov (United States)

Chamorro, David; Alarcón, Lourdes; Ponce, Arturo; Tapia, Rocio; González-Aguilar, Héctor; Robles-Flores, Martha; Mejía-Castillo, Teresa; Segovia, José; Bandala, Yamir; Juaristi, Eusebio; González-Mariscal, Lorenza

2009-09-01

Here, we have analyzed the subcellular destiny of newly synthesized tight junction protein zona occludens (ZO)-2. After transfection in sparse cells, 74% of cells exhibit ZO-2 at the nucleus, and after 18 h the value decreases to 17%. The mutation S369A located within the nuclear exportation signal 1 of ZO-2 impairs the nuclear export of the protein. Because Ser369 represents a putative protein kinase C (PKC) phosphorylation site, we tested the effect of PKC inhibition and stimulation on the nuclear export of ZO-2. Our results strongly suggest that the departure of ZO-2 from the nucleus is regulated by phosphorylation at Ser369 by novel PKCepsilon. To test the route taken by ZO-2 from synthesis to the plasma membrane, we devised a novel nuclear microinjection assay in which the nucleus served as a reservoir for anti-ZO-2 antibody. Through this assay, we demonstrate that a significant amount of newly synthesized ZO-2 goes into the nucleus and is later relocated to the plasma membrane. These results constitute novel information for understanding the mechanisms that regulate the intracellular fate of ZO-2.

Atmospheric Entry Studies for Venus Missions: 45 Sphere-Cone Rigid Aeroshells and Ballistic Entries

Science.gov (United States)

Prabhu, Dinesh K.; Spilker, Thomas R.; Allen, Gary A., Jr.; Hwang, Helen H.; Cappuccio, Gelsomina; Moses, Robert W.

2013-01-01

The present study considers direct ballistic entries into the atmosphere of Venus using a 45deg sphere-cone rigid aeroshell, a legacy shape that has been used successfully in the past in the Pioneer Venus Multiprobe Mission. For a number of entry mass and heatshield diameter combinations (i.e., various ballistic coefficients) and entry velocities, the trajectory space in terms of entry flight path angles between skip out and -30deg is explored with a 3DoF trajectory code, TRAJ. From these trajectories, the viable entry flight path angle space is determined through the use of mechanical and thermal performance limits on the thermal protection material and science payload; the thermal protection material of choice is entry-grade carbon phenolic, for which a material thermal response model is available. For mechanical performance, a 200 g limit is placed on the peak deceleration load experienced by the science instruments, and 10 bar is assumed as the pressure limit for entry-grade carbon-phenolic material. For thermal performance, inflection points in the total heat load distribution are used as cut off criteria. Analysis of the results shows the existence of a range of critical ballistic coefficients beyond which the steepest possible entries are determined by the pressure limit of the material rather than the deceleration load limit.

15 CFR 301.3 - Application for duty-free entry of scientific instruments.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Application for duty-free entry of scientific instruments. 301.3 Section 301.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE MISCELLANEOUS...

Cooperative development of nuclear safety regulations, guides and standards based on NUSS