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Sample records for registration hold sage

  1. 76 FR 54717 - Supervised Securities Holding Companies Registration

    Science.gov (United States)

    2011-09-02

    ... other financial statements submitted to the securities holding company's current consolidated supervisor... Y-9ES), The Supplement to the Consolidated Financial Statements for Bank Holding Companies (FR Y-9CS... Companies (FR Y-6), The Report of Foreign Banking Organizations (FR Y-7), The Consolidated Financial...

  2. 77 FR 32881 - Supervised Securities Holding Company Registration

    Science.gov (United States)

    2012-06-04

    ...), The Report of Foreign Banking Organizations (FR Y-7), The Consolidated Financial Statements for Bank... Y-9ES), The Supplement to the Consolidated Financial Statements for Bank Holding Companies (FR Y-9CS... comprehensive consolidated supervision by a foreign regulator, a nonbank financial company supervised by the...

  3. Registration factors that limit international mobility of people holding physiotherapy qualifications: A systematic review.

    Science.gov (United States)

    Foo, Jonathan S; Storr, Michael; Maloney, Stephen

    2016-06-01

    There is no enforced international standardisation of the physiotherapy profession. Thus, registration is used in many countries to maintain standards of care and to protect the public. However, registration may also limit international workforce mobility. What is known about the professional registration factors that may limit the international mobility of people holding physiotherapy qualifications? Systematic review using an electronic database search and hand searching of the World Confederation for Physical Therapy and International Network of Physiotherapy Regulatory Authorities websites. Analysis was conducted using thematic analysis. 10 articles and eight websites were included from the search strategy. Data is representative of high-income English speaking countries. Four themes emerged regarding limitations to professional mobility: practice context, qualification recognition, verification of fitness to practice, and incidental limitations arising from the registration process. Professional mobility is limited by differences in physiotherapy education programmes, resulting in varying standards of competency. Thus, it is often necessary to verify clinical competencies through assessments, as well as determining professional attributes and ability to apply competencies in a different practice context, as part of the registration process. There has been little evaluation of registration practices, and at present, there is a need to re-evaluate current registration processes to ensure they are efficient and effective, thereby enhancing workforce mobility. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  4. Contributions: SAGE

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Contributions: SAGE. Space Alternating Generalized Expectation (SAGE) Maximization algorithm provides an iterative approach to parameter estimation when direct maximization of the likelihood function may be infeasible. Complexity is less in those applications ...

  5. Sage grouse

    Science.gov (United States)

    Zimmerman, Shawna; Timmer, Jennifer M.; Aldridge, Cameron L.; Oyler-McCance, Sara J.; Braun, Clait E.; Young, Jessica R.

    2017-01-01

    Sage grouse are a group of chicken-sized birds with a unique breeding behavior and dependence on sagebrush shrubs (genus Artemisia) for food and shelter throughout their life cycle. In the last century, human population expansion throughout western North America has reduced the amount of sagebrush and degraded and fragmented the remaining areas. Vanishing sagebrush has resulted in sage grouse (genus Centrocercus) population declines and elevated conservation concern. Western Colorado is home to both species of sage grouse: greater sage grouse (Centrocercus urophasianus) and Gunnison sage grouse (Centrocercus minimus). Populations in the state, and throughout their range, have declined sufficiently to warrant consideration for federal protection for both species under the Endangered Species Act.

  6. Deep inspiration breath-hold radiotherapy for lung cancer: impact on image quality and registration uncertainty in cone beam CT image guidance

    DEFF Research Database (Denmark)

    Josipovic, Mirjana; Persson, Gitte F; Bangsgaard, Jens Peter

    2016-01-01

    OBJECTIVE: We investigated the impact of deep inspiration breath-hold (DIBH) and tumour baseline shifts on image quality and registration uncertainty in image-guided DIBH radiotherapy (RT) for locally advanced lung cancer. METHODS: Patients treated with daily cone beam CT (CBCT)-guided free...

  7. Deep inspiration breath-hold radiotherapy for lung cancer: impact on image quality and registration uncertainty in cone beam CT image guidance

    DEFF Research Database (Denmark)

    Josipovic, Mirjana; Persson, Gitte F; Bangsgaard, Jens Peter

    2016-01-01

    OBJECTIVE: We investigated the impact of deep inspiration breath-hold (DIBH) and tumour baseline shifts on image quality and registration uncertainty in image-guided DIBH radiotherapy (RT) for locally advanced lung cancer. METHODS: Patients treated with daily cone beam CT (CBCT)-guided free...... for the craniocaudal direction in FB, where it was >3 mm. On the 31st fraction, the intraobserver uncertainty increased compared with the second fraction. This increase was more pronounced in FB. Image quality scores improved in DIBH compared with FB for all parameters in all patients. Simulated tumour baseline shifts...... ≤2 mm did not affect the CBCT image quality considerably. CONCLUSION: DIBH CBCT improved image quality and reduced registration uncertainty in the craniocaudal direction in image-guided RT of locally advanced lung cancer. Baseline shifts ≤2 mm in DIBH during CBCT acquisition did not affect image...

  8. SAGE results

    International Nuclear Information System (INIS)

    Gavrin, V.N.

    1996-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) is described. The solar neutrino flux measured by 31 extractions through October, 1993 is presented. The result of 69+/-10(stat)+5/-7(syst) SNU is to be compared with a Standard Solar Model prediction of 132 SNU. The initial results of a measurement of experimental efficiencies are also discussed by exposing the gallium target to neutrinos from an artificial source. The capture rate of neutrinos from this source is very close to that which is expected. The result can be expressed as a ratio of the measured capture rate to the anticipated rate from the source activity. This ratio is 0.93+0.15, -0.17 where the systematic and statistical errors have been combined. To first order the experimental efficiencies are in agreement with those determined during solar neutrino measurements and in previous auxiliary measurements. One must conclude that the discrepancy between the measured solar neutrino flux and that predicted by the solar models can not arise from an experimental artifact. (author)

  9. SAGE IV Pathfinder

    Data.gov (United States)

    National Aeronautics and Space Administration — Utilizing a unique, new occultation technique involving imaging, the SAGE IV concept will meet or exceed the quality of previous SAGE measurements at a small...

  10. Results from SAGE II

    International Nuclear Information System (INIS)

    Nico, J.S.

    1994-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first nine runs of SAGE II give a capture rate of 66 -13 +18 (stat) -7 +5 (sys) SNU. Combined with the SAGE I result of 73 -16 +18 (stat) -7 5 (sys) SNU, the capture rate is 69 -11 +11 (stat) -7 +5 (sys) SNU. This represents only 52%--56% of the capture rate predicted by different Standard Solar Models

  11. Cardiac dosimetric evaluation of deep inspiration breath-hold level variances using computed tomography scans generated from deformable image registration displacement vectors

    International Nuclear Information System (INIS)

    Harry, Taylor; Rahn, Doug; Semenov, Denis; Gu, Xuejun; Yashar, Catheryn; Einck, John; Jiang, Steve; Cerviño, Laura

    2016-01-01

    There is a reduction in cardiac dose for left-sided breast radiotherapy during treatment with deep inspiration breath-hold (DIBH) when compared with treatment with free breathing (FB). Various levels of DIBH may occur for different treatment fractions. Dosimetric effects due to this and other motions are a major component of uncertainty in radiotherapy in this setting. Recent developments in deformable registration techniques allow displacement vectors between various temporal and spatial patient representations to be digitally quantified. We propose a method to evaluate the dosimetric effect to the heart from variable reproducibility of DIBH by using deformable registration to create new anatomical computed tomography (CT) scans. From deformable registration, 3-dimensional deformation vectors are generated with FB and DIBH. The obtained deformation vectors are scaled to 75%, 90%, and 110% and are applied to the reference image to create new CT scans at these inspirational levels. The scans are then imported into the treatment planning system and dose calculations are performed. The average mean dose to the heart was 2.5 Gy (0.7 to 9.6 Gy) at FB, 1.2 Gy (0.6 to 3.8 Gy, p < 0.001) at 75% inspiration, 1.1 Gy (0.6 to 3.1 Gy, p = 0.004) at 90% inspiration, 1.0 Gy (0.6 to 3.0 Gy) at 100% inspiration or DIBH, and 1.0 Gy (0.6 to 2.8 Gy, p = 0.019) at 110% inspiration. The average mean dose to the left anterior descending artery (LAD) was 19.9 Gy (2.4 to 46.4 Gy), 8.6 Gy (2.0 to 43.8 Gy, p < 0.001), 7.2 Gy (1.9 to 40.1 Gy, p = 0.035), 6.5 Gy (1.8 to 34.7 Gy), and 5.3 Gy (1.5 to 31.5 Gy, p < 0.001), correspondingly. This novel method enables numerous anatomical situations to be mimicked and quantifies the dosimetric effect they have on a treatment plan.

  12. Cardiac dosimetric evaluation of deep inspiration breath-hold level variances using computed tomography scans generated from deformable image registration displacement vectors

    Energy Technology Data Exchange (ETDEWEB)

    Harry, Taylor [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA (United States); Department of Radiation Medicine, Oregon Health and Science University, Portland, OR (United States); Department of Nuclear Engineering and Radiation Health Physics, Oregon State University, Corvallis, OR (United States); Rahn, Doug; Semenov, Denis [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA (United States); Gu, Xuejun [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Yashar, Catheryn; Einck, John [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA (United States); Jiang, Steve [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Cerviño, Laura, E-mail: lcervino@ucsd.edu [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA (United States)

    2016-04-01

    There is a reduction in cardiac dose for left-sided breast radiotherapy during treatment with deep inspiration breath-hold (DIBH) when compared with treatment with free breathing (FB). Various levels of DIBH may occur for different treatment fractions. Dosimetric effects due to this and other motions are a major component of uncertainty in radiotherapy in this setting. Recent developments in deformable registration techniques allow displacement vectors between various temporal and spatial patient representations to be digitally quantified. We propose a method to evaluate the dosimetric effect to the heart from variable reproducibility of DIBH by using deformable registration to create new anatomical computed tomography (CT) scans. From deformable registration, 3-dimensional deformation vectors are generated with FB and DIBH. The obtained deformation vectors are scaled to 75%, 90%, and 110% and are applied to the reference image to create new CT scans at these inspirational levels. The scans are then imported into the treatment planning system and dose calculations are performed. The average mean dose to the heart was 2.5 Gy (0.7 to 9.6 Gy) at FB, 1.2 Gy (0.6 to 3.8 Gy, p < 0.001) at 75% inspiration, 1.1 Gy (0.6 to 3.1 Gy, p = 0.004) at 90% inspiration, 1.0 Gy (0.6 to 3.0 Gy) at 100% inspiration or DIBH, and 1.0 Gy (0.6 to 2.8 Gy, p = 0.019) at 110% inspiration. The average mean dose to the left anterior descending artery (LAD) was 19.9 Gy (2.4 to 46.4 Gy), 8.6 Gy (2.0 to 43.8 Gy, p < 0.001), 7.2 Gy (1.9 to 40.1 Gy, p = 0.035), 6.5 Gy (1.8 to 34.7 Gy), and 5.3 Gy (1.5 to 31.5 Gy, p < 0.001), correspondingly. This novel method enables numerous anatomical situations to be mimicked and quantifies the dosimetric effect they have on a treatment plan.

  13. The SAGE spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Pakarinen, J.; Papadakis, P. [University of Liverpool, Department of Physics, Oliver Lodge Laboratory, Liverpool (United Kingdom); University of Jyvaeskylae, Department of Physics, Jyvaeskylae (Finland); Sorri, J.; Greenlees, P.T.; Jones, P.; Julin, R.; Konki, J.; Rahkila, P.; Sandzelius, M. [University of Jyvaeskylae, Department of Physics, Jyvaeskylae (Finland); Herzberg, R.D.; Butler, P.A.; Cox, D.M.; Cresswell, J.R.; Mistry, A.; Page, R.D.; Parr, E.; Sampson, J.; Seddon, D.A.; Thornhill, J.; Wells, D. [University of Liverpool, Department of Physics, Oliver Lodge Laboratory, Liverpool (United Kingdom); Coleman-Smith, P.J.; Lazarus, I.H.; Letts, S.C.; Pucknell, V.F.E.; Simpson, J. [STFC Daresbury Laboratory, Warrington (United Kingdom)

    2014-03-15

    The SAGE spectrometer has been constructed for in-beam nuclear structure studies. SAGE combines a Ge-detector array and an electron spectrometer for detection of γ-rays and internal conversion electrons, respectively, and allows simultaneous observation of both electrons and γ-rays emitted from excited nuclei. SAGE is set up in the Accelerator Laboratory of the University of Jyvaeskylae and works in conjunction with the RITU gas-filled recoil separator and the GREAT focal-plane spectrometer allowing the use of the recoil-decay tagging method. (orig.)

  14. The SAGE spectrometer

    International Nuclear Information System (INIS)

    Pakarinen, J.; Papadakis, P.; Sorri, J.; Greenlees, P.T.; Jones, P.; Julin, R.; Konki, J.; Rahkila, P.; Sandzelius, M.; Herzberg, R.D.; Butler, P.A.; Cox, D.M.; Cresswell, J.R.; Mistry, A.; Page, R.D.; Parr, E.; Sampson, J.; Seddon, D.A.; Thornhill, J.; Wells, D.; Coleman-Smith, P.J.; Lazarus, I.H.; Letts, S.C.; Pucknell, V.F.E.; Simpson, J.

    2014-01-01

    The SAGE spectrometer has been constructed for in-beam nuclear structure studies. SAGE combines a Ge-detector array and an electron spectrometer for detection of γ-rays and internal conversion electrons, respectively, and allows simultaneous observation of both electrons and γ-rays emitted from excited nuclei. SAGE is set up in the Accelerator Laboratory of the University of Jyvaeskylae and works in conjunction with the RITU gas-filled recoil separator and the GREAT focal-plane spectrometer allowing the use of the recoil-decay tagging method. (orig.)

  15. Results from SAGE

    International Nuclear Information System (INIS)

    Abdurashitov, J.N.; Gavrin, V.N.; Girin, S.V.

    1996-01-01

    The Russian-American Gallium Solar Neutrino Experiment (SAGE) is described. Beginning in September 1992, SAGE II data were taken with 55 tons of Ga and with significantly reduced backgrounds. The solar neutrino flux measured by 31 extractions through October 1993 is presented. The result of 69 ± 10 +5/-7 SNU is to be compared with a Standard Solar Model prediction of 132 SNU

  16. Numerical analysis using Sage

    CERN Document Server

    Anastassiou, George A

    2015-01-01

    This is the first numerical analysis text to use Sage for the implementation of algorithms and can be used in a one-semester course for undergraduates in mathematics, math education, computer science/information technology, engineering, and physical sciences. The primary aim of this text is to simplify understanding of the theories and ideas from a numerical analysis/numerical methods course via a modern programming language like Sage. Aside from the presentation of fundamental theoretical notions of numerical analysis throughout the text, each chapter concludes with several exercises that are oriented to real-world application.  Answers may be verified using Sage.  The presented code, written in core components of Sage, are backward compatible, i.e., easily applicable to other software systems such as Mathematica®.  Sage is  open source software and uses Python-like syntax. Previous Python programming experience is not a requirement for the reader, though familiarity with any programming language is a p...

  17. Sage for undergraduates

    CERN Document Server

    Bard, Gregory V

    2015-01-01

    Professor Bard has provided a valuable service by carefully explaining everything an undergraduate student of mathematics, or a teacher of these topics, needs to get started with Sage quickly and easily. It will also be useful for any student or teacher of another STEM discipline. There is an excellent mix of the most frequently used commands, along with warnings about common pitfalls or caveats. I highly recommend it for anyone new to Sage, or who desires an overview of the system's impressive capabilities. -Robert A. Beezer, University of Puget Sound This book is a sort of "Missing Manual"

  18. Solar neutrino results from SAGE

    International Nuclear Information System (INIS)

    Gavrin, V.N.

    1999-01-01

    We report the status of the Russian-American Gallium solar neutrino Experiment (SAGE). The solar neutrino result for SAGE III, 20 runs during the measuring period May 1995 through December 1997, is 56.7 +9.3/-8.7(stat.)+4.6/-4.8(syst.) SNU. The combined result for 57 measurements from 1990 through 1997 (SAGE I+II+III) is 66.9 +7.1/-6.8 (stat) +5.4/-5.7 (syst) SNU. The final result of the SAGE 51 Cr experiment to check the response of SAGE to low energy neutrinos is also presented

  19. 76 FR 37826 - Notice of Availability of the Environmental Assessment and Notice of Public Hearing for the Sage...

    Science.gov (United States)

    2011-06-28

    ...In accordance with the Federal coal management regulations, the Sage Creek Holdings, LLC, Federal Coal Lease-By-Application (LBA) Environmental Assessment (EA) is available for public review and comment. The Department of the Interior, Bureau of Land Management (BLM) Colorado State Office, will hold a public hearing to receive comments on the EA, Fair Market Value (FMV), and Maximum Economic Recovery (MER) of the coal resources for Sage Creek Holdings, LLC, COC- 74219.

  20. 75 FR 49512 - Notice of Availability of the Environmental Assessment and Notice of Public Hearing for the Sage...

    Science.gov (United States)

    2010-08-13

    ...In accordance with the Federal coal management regulations, the Sage Creek Holdings, LLC Federal Coal Lease-By-Application (LBA) Environmental Assessment (EA) is available for public review and comment. The Department of the Interior, Bureau of Land Management (BLM) Colorado State Office will hold a public hearing to receive comments on the EA, Finding of No Significant Impact (FONSI), Fair Market Value (FMV), and Maximum Economic Recovery (MER) of the coal resources for Sage Creek Holdings, LLC LBA COC-74219.

  1. SAGE Version 7.0 Algorithm: Application to SAGE II

    Science.gov (United States)

    Damadeo, R. P; Zawodny, J. M.; Thomason, L. W.; Iyer, N.

    2013-01-01

    This paper details the Stratospheric Aerosol and Gas Experiments (SAGE) version 7.0 algorithm and how it is applied to SAGE II. Changes made between the previous (v6.2) and current (v7.0) versions are described and their impacts on the data products explained for both coincident event comparisons and time-series analysis. Users of the data will notice a general improvement in all of the SAGE II data products, which are now in better agreement with more modern data sets (e.g. SAGE III) and more robust for use with trend studies.

  2. First results from SAGE II

    International Nuclear Information System (INIS)

    Abdurashitov, J.N.; Faizov, E.L.; Gavrin, V.N.

    1994-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76 -18 +21 (stat) -7 +5 (sys) SNU. combined with the SAGE I result, the capture rate is 74 -12 +13 (stat) -7 +5 (sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models

  3. First results from SAGE II

    International Nuclear Information System (INIS)

    Aburashitov, J.N.; Faizov, E.L.; Gavrin, V.N.; Gusev, A.O.; Kalikhov, A.V.; Knodel, T.V.; Knyshenko, I.I.; Kornoukhov, V.N.; Mirmov, I.N.; Pshukov, A.M.; Shalagin, A.M.; Shikhin, A.A.; Timofeyev, P.V.; Veretenkin, E.P.; Vermul, V.M.; Zatsepin, G.T.; Bowles, T.J.; Nico, J.S.; Teasdale, W.A.; Wark, D.L.; Wilkerson, J.F.; Cleveland, B.T.; Daily, T.; Davis, R. Jr.; Lande, K.; Lee, C.K.; Wildenhain, P.W.; Elliott, S.R.; Cherry, M.L.

    1995-01-01

    The Russian-American Gallium solar neutrino Experiment (SAGE) began the second phase of operation (SAGE II) in September of 1992. Monthly measurements of the integral flux of solar neutrinos have been made with 55 tonnes of gallium. The K-peak results of the first five runs of SAGE II give a capture rate of 76 +21 -18 (stat) +5 -7 (sys) SNU. Combined with the SAGE I result, the capture rate is 74 +13 -12 (stat) +5 -7 (sys) SNU. This represents only 56%--60% of the capture rate predicted by different Standard Solar Models. copyright 1995 American Institute of Physics

  4. Serial analysis of gene expression (SAGE)

    NARCIS (Netherlands)

    van Ruissen, Fred; Baas, Frank

    2007-01-01

    In 1995, serial analysis of gene expression (SAGE) was developed as a versatile tool for gene expression studies. SAGE technology does not require pre-existing knowledge of the genome that is being examined and therefore SAGE can be applied to many different model systems. In this chapter, the SAGE

  5. Simulation of the SAGE spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Cox, D.M.; Herzberg, R.D. [University of Liverpool, Department of Physics, Oliver Lodge Laboratory, Liverpool (United Kingdom); Konki, J.; Greenlees, P.T.; Pakarinen, J.; Papadakis, P.; Rahkila, P.; Sandzelius, M.; Sorri, J. [University of Jyvaeskylae, Department of Physics, Jyvaeskylae (Finland); Hauschild, K. [Universite Paris-Sud, CSNSM-IN2P3-CNRS, Orsay (France)

    2015-06-15

    The SAGE spectrometer combines a Ge-detector array with a Si detector to allow simultaneous detection of γ-rays and electrons. A comprehensive GEANT4 simulation package of the SAGE spectrometer has been developed with the ability to simulate the expected datasets based on user input files. The measured performance of the spectrometer is compared to the results obtained from the simulations. (orig.)

  6. Simulation of the SAGE spectrometer

    International Nuclear Information System (INIS)

    Cox, D.M.; Herzberg, R.D.; Konki, J.; Greenlees, P.T.; Pakarinen, J.; Papadakis, P.; Rahkila, P.; Sandzelius, M.; Sorri, J.; Hauschild, K.

    2015-01-01

    The SAGE spectrometer combines a Ge-detector array with a Si detector to allow simultaneous detection of γ-rays and electrons. A comprehensive GEANT4 simulation package of the SAGE spectrometer has been developed with the ability to simulate the expected datasets based on user input files. The measured performance of the spectrometer is compared to the results obtained from the simulations. (orig.)

  7. Registration and Summation of Respiratory-Gated or Breath-Hold PET Images Based on Deformation Estimation of Lung from CT Image

    Directory of Open Access Journals (Sweden)

    Hideaki Haneishi

    2016-01-01

    Full Text Available Lung motion due to respiration causes image degradation in medical imaging, especially in nuclear medicine which requires long acquisition times. We have developed a method for image correction between the respiratory-gated (RG PET images in different respiration phases or breath-hold (BH PET images in an inconsistent respiration phase. In the method, the RG or BH-PET images in different respiration phases are deformed under two criteria: similarity of the image intensity distribution and smoothness of the estimated motion vector field (MVF. However, only these criteria may cause unnatural motion estimation of lung. In this paper, assuming the use of a PET-CT scanner, we add another criterion that is the similarity for the motion direction estimated from inhalation and exhalation CT images. The proposed method was first applied to a numerical phantom XCAT with tumors and then applied to BH-PET image data for seven patients. The resultant tumor contrasts and the estimated motion vector fields were compared with those obtained by our previous method. Through those experiments we confirmed that the proposed method can provide an improved and more stable image quality for both RG and BH-PET images.

  8. SAGE 1 data user's guide

    International Nuclear Information System (INIS)

    Mcmaster, L.R.; Chu, W.P.; Rowland, M.W.

    1992-08-01

    A guide for using the data products from the Stratospheric Aerosol and Gas Experiment 1 (SAGE 1) for scientific investigations of stratospheric chemistry related to aerosol, ozone, nitrogen dioxide, dynamics, and climate change is presented. A detailed description of the aerosol profile tape, the ozone profile tape, and the nitrogen dioxide profile tape is included. These tapes are the SAGE 1 data products containing aerosol extinction data and ozone and nitrogen dioxide concentration data for use in the different scientific investigations. Brief descriptions of the instrument operation, data collection, processing, and validation, and some of the scientific analyses that were conducted are also included

  9. The Mouse SAGE Site: database of public mouse SAGE libraries

    Czech Academy of Sciences Publication Activity Database

    Divina, Petr; Forejt, Jiří

    2004-01-01

    Roč. 32, - (2004), s. D482-D483 ISSN 0305-1048 R&D Projects: GA MŠk LN00A079; GA ČR GV204/98/K015 Grant - others:HHMI(US) 555000306 Institutional research plan: CEZ:AV0Z5052915 Keywords : mouse SAGE libraries * web -based database Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 7.260, year: 2004

  10. 12 CFR 583.18 - Registrant.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Registrant. 583.18 Section 583.18 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY DEFINITIONS FOR REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.18 Registrant. The term registrant means a savings and loan...

  11. Mitigation effectiveness for improving nesting success of greater sage-grouse influenced by energy development

    Science.gov (United States)

    Kirol, Christopher P.; Sutphin, Andrew L.; Bond, Laura S.; Fuller, Mark R.; Maechtle, Thomas L.

    2015-01-01

    Sagebrush Artemisia spp. habitats being developed for oil and gas reserves are inhabited by sagebrush obligate species — including the greater sage-grouse Centrocercus urophasianus (sage-grouse) that is currently being considered for protection under the U.S. Endangered Species Act. Numerous studies suggest increasing oil and gas development may exacerbate species extinction risks. Therefore, there is a great need for effective on-site mitigation to reduce impacts to co-occurring wildlife such as sage-grouse. Nesting success is a primary factor in avian productivity and declines in nesting success are also thought to be an important contributor to population declines in sage-grouse. From 2008 to 2011 we monitored 296 nests of radio-marked female sage-grouse in a natural gas (NG) field in the Powder River Basin, Wyoming, USA, and compared nest survival in mitigated and non-mitigated development areas and relatively unaltered areas to determine if specific mitigation practices were enhancing nest survival. Nest survival was highest in relatively unaltered habitats followed by mitigated, and then non-mitigated NG areas. Reservoirs used for holding NG discharge water had the greatest support as having a direct relationship to nest survival. Within a 5-km2 area surrounding a nest, the probability of nest failure increased by about 15% for every 1.5 km increase in reservoir water edge. Reducing reservoirs was a mitigation focus and sage-grouse nesting in mitigated areas were exposed to almost half of the amount of water edge compared to those in non-mitigated areas. Further, we found that an increase in sagebrush cover was positively related to nest survival. Consequently, mitigation efforts focused on reducing reservoir construction and reducing surface disturbance, especially when the surface disturbance results in sagebrush removal, are important to enhancing sage-grouse nesting success.

  12. Technology Tips: Building Interactive Demonstrations with Sage

    Science.gov (United States)

    Murray, Maura

    2013-01-01

    Sage is an open-source software package that can be used in many different areas of mathematics, ranging from algebra to calculus and beyond. One of the most exciting pedagogical features of Sage (http://www.sagemath.org) is its ability to create interacts--interactive examples that can be used in a classroom demonstration or by students in a…

  13. Solar neutrino results from SAGE

    International Nuclear Information System (INIS)

    Gavrin, V.N.

    2001-01-01

    The results of ten years of solar neutrino observation by the Russian-American gallium solar neutrino experiment (SAGE) are reported. The overall result of 70 runs during the measurement period from January 1990 to October 1999 is 75.4 -6.8 +7.0 (stat.) -3.0 +3.5 (syst) SNU. This represents only slightly more than half of the predicted standard solar model rate of 129 SNU. The individual results on each run, and the results of combined analysis of all runs during each year, as well as the results of combined analysis of all runs during monthly and bimonthly periods are presented

  14. Solar neutrino results from SAGE

    International Nuclear Information System (INIS)

    Gavrin, V.N.

    2000-01-01

    We report the results of ten years of solar neutrino observation by the Russian-American Gallium solar neutrino Experiment (SAGE). The overall result of 70 runs during the measurement period January 1990 to October 1999 is 75.4 + 7.0/-6.8 (stat.) +3.5/-3.0 (syst.) SNU. This represents only slightly more than half of the predicted standard solar model rate of 129 SNU. The individual results of each run, and the results of combined analysis of all runs during each year, as well as the results of combined analysis of all runs during monthly and bimonthly periods are presented

  15. Registration Service

    CERN Multimedia

    GS Department

    2010-01-01

    Following a reorganization in Building 55, please note that the Registration Service is now organised as follows :  Ground floor: access cards (76903). 1st floor : registration of external firms’ personnel (76611 / 76622); car access stickers (76633); biometric registration (79710). Opening hours: 07-30 to 16-00 non-stop. GS-SEM Group General Infrastructure Services Department

  16. Sage

    Science.gov (United States)

    ... oil is considered a toxic dose. Keep in Mind Tell all your health care providers about any ... Privacy and Policies Accessibility en Español FOIA Site Map Contact Us U.S. Department of Health & Human Services , ...

  17. The radon influence of SAGE results

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Gorbachev, V.V.; Mirmov, I.N.

    2002-01-01

    The method for evaluating systematic errors, connected with radon, is described in the experiment on determining the SAGE solar neutrino flux. The systematic error by the measured neutrino capture rate in the gallium 75 SNU target does not exceed 0.3 SNU. The obtained value (0.3 SNU) is the upper limit of the radon systematic error. Its low value means, that radon does not contribute significantly to the SAGE result [ru

  18. Holding fast.

    Science.gov (United States)

    Gourville, John T

    2005-06-01

    CEO Peter Walsh faces a classic innovator's dilemma. His company, Crescordia, produces high-quality metal plates, pins, and screws that orthopedic surgeons use to repair broken bones. In fact, because the company has for decades refused to compromise on quality, there are orthopedic surgeons who use nothing but Crescordia hardware. And now these customers have begun to clamor for the next generation technology: resorbable hardware. Resorbables offer clear advantages over the traditional hardware. Like dissolving sutures, resorbable plates and screws are made of biodegradable polymers. They hold up long enough to support a healing bone, then gradually and harmlessly disintegrate in the patient's body. Surgeons are especially looking forward to using resorbables on children, so kids won't have to undergo a second operation to remove the old hardware after their bones heal, a common procedure in pediatrics. The new products, however, are not yet reliable; they fail about 8% of the time, sometimes disintegrating before the bone completely heals and sometimes not ever fully disintegrating. That's why Crescordia, mindful of its hard-earned reputation, has delayed launching a line using the new technology. But time is running out. A few competitors have begun to sell resorbables despite their imperfections, and these companies are picking up market share. Should Crescordia join the fray and risk tarnishing its brand? Or should the company sit tight until it can offer a perfect product? Commenting on this fictional case study are Robert A. Lutz, vice chairman of product development at General Motors; Clayton M. Christensen, the Robert and Jane Cizik Professor of Business Administration at Harvard Business School; Jason Wittes, a senior equity analyst covering medical supplies and devices at Leerink Swann; and Nick Galakatos, a general partner of MPM Capital.

  19. SAGE: String-overlap Assembly of GEnomes.

    Science.gov (United States)

    Ilie, Lucian; Haider, Bahlul; Molnar, Michael; Solis-Oba, Roberto

    2014-09-15

    De novo genome assembly of next-generation sequencing data is one of the most important current problems in bioinformatics, essential in many biological applications. In spite of significant amount of work in this area, better solutions are still very much needed. We present a new program, SAGE, for de novo genome assembly. As opposed to most assemblers, which are de Bruijn graph based, SAGE uses the string-overlap graph. SAGE builds upon great existing work on string-overlap graph and maximum likelihood assembly, bringing an important number of new ideas, such as the efficient computation of the transitive reduction of the string overlap graph, the use of (generalized) edge multiplicity statistics for more accurate estimation of read copy counts, and the improved use of mate pairs and min-cost flow for supporting edge merging. The assemblies produced by SAGE for several short and medium-size genomes compared favourably with those of existing leading assemblers. SAGE benefits from innovations in almost every aspect of the assembly process: error correction of input reads, string-overlap graph construction, read copy counts estimation, overlap graph analysis and reduction, contig extraction, and scaffolding. We hope that these new ideas will help advance the current state-of-the-art in an essential area of research in genomics.

  20. SAGE as a Source for Undergraduate Research Projects

    Science.gov (United States)

    Hutz, Benjamin

    2017-01-01

    This article examines the use of the computer algebra system SAGE for undergraduate student research projects. After reading this article, the reader should understand the benefits of using SAGE as a source of research projects and how to commence working with SAGE. The author proposes a tiered working group model to allow maximum benefit to the…

  1. Evaluating lek occupancy of greater sage-grouse in relation to landscape cultivation in the Dakotas

    Science.gov (United States)

    Smith, Joe T.; Flake, Lester D.; Higgins, Kenneth F.; Kobriger, Gerald D.; Homer, Collin G.

    2005-01-01

    Greater Sage-Grouse (Centrocercus urophasianus) have been declining in many states and provinces of North America, and North and South Dakota hold no exception to these declines. We studied effects of cultivated land on Greater Sage-Grouse lek abandonment in North and South Dakota. Landscape-level data were assessed using satellite imagery within a geographic information system. Comparisons were made of 1972-1976 and 1999-2000 percent cultivated and noncultivated land. These comparisons were made between land uses surrounding active leks versus inactive leks, active leks versus random locations, and abandoned regions versus active regions. The 1999-2000 imagery illustrated that percent cultivated land was greater near abandoned leks (4-km buffers) than near active leks in North Dakota or random sites, but this did not hold true in South Dakota. Comparison of an extensive region of abandoned leks with a region of active leks in North Dakota illustrated a similar increase as well as dispersion of cultivation within the abandoned region. However, 1972-1976 imagery revealed that this relationship between percentage of cultivated land and lek activity in North Dakota has been static over the last 30 years. Thus, if the decline of Greater Sage-Grouse is the result of cultivated land infringements, it occurred prior to 1972 in North Dakota.

  2. The SAGE Model of Social Psychological Research.

    Science.gov (United States)

    Power, Séamus A; Velez, Gabriel; Qadafi, Ahmad; Tennant, Joseph

    2018-05-01

    We propose a SAGE model for social psychological research. Encapsulated in our acronym is a proposal to have a synthetic approach to social psychological research, in which qualitative methods are augmentative to quantitative ones, qualitative methods can be generative of new experimental hypotheses, and qualitative methods can capture experiences that evade experimental reductionism. We remind social psychological researchers that psychology was founded in multiple methods of investigation at multiple levels of analysis. We discuss historical examples and our own research as contemporary examples of how a SAGE model can operate in part or as an integrated whole. The implications of our model are discussed.

  3. Validation of SAGE II ozone measurements

    Science.gov (United States)

    Cunnold, D. M.; Chu, W. P.; Mccormick, M. P.; Veiga, R. E.; Barnes, R. A.

    1989-01-01

    Five ozone profiles from the Stratospheric Aerosol and Gas Experiment (SAGE) II are compared with coincident ozonesonde measurements obtained at Natal, Brazil, and Wallops Island, Virginia. It is shown that the mean difference between all of the measurements is about 1 percent and that the agreement is within 7 percent at altitudes between 20 and 53 km. Good agreement is also found for ozone mixing ratios on pressure surfaces. It is concluded that the SAGE II profiles provide useful ozone information up to about 60 km altitude.

  4. The SAGE Model of Social Psychological Research

    Science.gov (United States)

    Power, Séamus A.; Velez, Gabriel; Qadafi, Ahmad; Tennant, Joseph

    2018-01-01

    We propose a SAGE model for social psychological research. Encapsulated in our acronym is a proposal to have a synthetic approach to social psychological research, in which qualitative methods are augmentative to quantitative ones, qualitative methods can be generative of new experimental hypotheses, and qualitative methods can capture experiences that evade experimental reductionism. We remind social psychological researchers that psychology was founded in multiple methods of investigation at multiple levels of analysis. We discuss historical examples and our own research as contemporary examples of how a SAGE model can operate in part or as an integrated whole. The implications of our model are discussed. PMID:29361241

  5. Technology evaluation: SAGE, Genzyme molecular oncology.

    Science.gov (United States)

    Bartlett, J

    2001-02-01

    Genzyme Molecular Oncology (GMO) is using its SAGE (Serial Analysis of Gene Expression) combinatorial chemistry technology to screen compound libraries. SAGE is a high-throughput, high-efficiency method to simultaneously detect and measure the expression levels of genes expressed in a cell at a given time, including rare genes. SAGE can be used in a wide variety of applications to identify disease-related genes, to analyze the effect of drugs on tissues and to provide insights into disease pathways. It works by isolating short fragments of genetic information from the expressed genes that are present in the cell being studied. These short sequences, called SAGE tags, are linked together for efficient sequencing. The sequence data are then analyzed to identify each gene expressed in the cell and the levels at which each gene is expressed. This information forms a library that can be used to analyze the differences in gene expression between cells [293437]. By December 1999, GMO had identified a set of 40 genes from 3.5 million transcripts that were expressed at elevated levels in all cancer tissue but not seen in normal tissue. The company hope these may provide diagnostic markers or therapeutic targets. The studies also provided data furthering the understanding of the way cells use their genome [349968]. GMO has signed a collaborative agreement with the National Cancer Institute (NCI) to search for new drug candidates in the field of cancer chemotherapy. The collaboration combines GMO's SAGE technology with the NCI's extensive array of 60 cell-based cancer screens. Under the agreement, the NCI will evaluate Genzyme's library consisting of one million compounds against selected cancer screens to identify compounds with anticancer properties [255082]. Xenometrix granted a license agreement for gene expression profiling to GMO in February 1999, giving company access to claims covered in issued US and European patents. The license is non-exclusive and covers the

  6. SAGES Guidelines: Prevention and management of gastro ...

    African Journals Online (AJOL)

    SAGES Guidelines: Prevention and management of gastro-oesophageal varices and variceal haemorrhage in cirrhosis. J F Botha. Abstract. No Abstract South African Gastroenterology Review Vol. 6 (1) 2008: pp. 23-25. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  7. Effect of radon on SAGE results

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Gorbachev, V.V.; Mirmov, I.N.

    2002-01-01

    A method for estimating the systematic uncertainty associated with radon in the SAGE experiment aimed at observing the solar-neutrino flux is described. For the gallium target used in this experiment, the systematic uncertainty in the measured neutrino-capture rate of 75 SNU is below 0.3 SNU

  8. Lessons learned with the SAGE spectrometer

    International Nuclear Information System (INIS)

    Sorri, J; Greenlees, P T; Jones, P; Julin, R; Konki, J; Pakarinen, J; Rahkila, P; Sandzelius, M; Uusitalo, J; Papadakis, P; Cox, D M; Herzberg, R D

    2012-01-01

    The SAGE spectrometer combines a high-efficiency γ-ray detection system with an electron spectrometer. Some of the design features have been known to be problematic and surprises have come up during the early implementation of the spectrometer. Tests related to bismuth germanate Compton-suppression shields, electron detection efficiency and an improved cooling system are discussed in the paper. (paper)

  9. Sage grouse on the Idaho National Environmental Research Park

    International Nuclear Information System (INIS)

    Connelly, J.W.; Ball, I.J.

    1983-01-01

    A comprehensive study of sage grouse (Centrocercus urophasianus) ecology was conducted on the Idaho National Engineering Laboratory (INEL) site between June 1977 and May 1981. Sage grouse used lawns surrounding INEL facilities for feeding and loafing throughot the summer. Mean summer home range was 406 ha for adult female sage grouse and 94 ha for juveniles. Radionuclide concentrations in grouse summering near a liquid radioactive waste disposal area (N = 29) were significantly higher than those in grouse summering near a solid radioactive waste disposal area (N = 14) or control areas (N = 20). Sage grouse moved from 2 to 83 km during seasonal migration. Fall movements from INEL facilities to winter range were slow and meandering. Spring movements of females from leks to summer range were also slow and meandering but male movements appeared rapid and direct. Sage grouse remained in segregated flocks during early summer but the number of mixed sex flocks increased in late summer. Sage grouse occurred in segregated flocks throughout the winter. Both flock type and habitat influenced winter sage grouse flock size. Mean flock size remained relatively constant as winter weather became more severe. Agricultural aras were an important component of sage grouse summer range and were preferred by all sage grouse sex and age classes. Sage grouse winter range was generally characterized by sagebrush stands with 11 to 30% canopy coverage

  10. Electric Holding Company Areas

    Data.gov (United States)

    Department of Homeland Security — Holding companies are electric power utilities that have a holding company structure. This vector polygon layer represents the area served by electric power holding...

  11. 78 FR 59368 - Notice of Public Meeting: Northeast California Resource Advisory Council Sage Grouse Conservation...

    Science.gov (United States)

    2013-09-26

    ... Public Meeting: Northeast California Resource Advisory Council Sage Grouse Conservation Subcommittee and...) Northeast California Resource Advisory Council's sage grouse conservation subcommittee and the full Resource... conservation of sage grouse habitat. On November 12, the subcommittee will develop a recommendation for...

  12. 12 CFR 584.1 - Registration, examination and reports.

    Science.gov (United States)

    2010-01-01

    ... Section 584.1 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SAVINGS AND LOAN... loan holding company, each savings and loan holding company shall register with the OTS by filing a registration statement H-(b)10. (2) Filing of annual/current reports. Each registered savings and loan holding...

  13. Shaping asteroid models using genetic evolution (SAGE)

    Science.gov (United States)

    Bartczak, P.; Dudziński, G.

    2018-02-01

    In this work, we present SAGE (shaping asteroid models using genetic evolution), an asteroid modelling algorithm based solely on photometric lightcurve data. It produces non-convex shapes, orientations of the rotation axes and rotational periods of asteroids. The main concept behind a genetic evolution algorithm is to produce random populations of shapes and spin-axis orientations by mutating a seed shape and iterating the process until it converges to a stable global minimum. We tested SAGE on five artificial shapes. We also modelled asteroids 433 Eros and 9 Metis, since ground truth observations for them exist, allowing us to validate the models. We compared the derived shape of Eros with the NEAR Shoemaker model and that of Metis with adaptive optics and stellar occultation observations since other models from various inversion methods were available for Metis.

  14. SAGE 2.1: SOLVENT ALTERNATIVES GUIDE: USER'S GUIDE

    Science.gov (United States)

    The guide provides instruction for using the SAGE (Solvent Alternatives GuidE) software system, version 2.1. SAGE recommends solvent replacements in cleaning and degreasing operations. It leads the user through a question-and-answer session. The user's responses allow the system ...

  15. Ecology of greater sage-grouse in the Dakotas

    Science.gov (United States)

    Christopher C. Swanson

    2009-01-01

    Greater sage-grouse (Centrocercus urophasianus) populations and the sagebrush (Artemisia spp.) communities that they rely on have dramatically declined from historic levels. Moreover, information regarding sage-grouse annual life-history requirements at the eastern-most extension of sagebrush steppe communities is lacking....

  16. Statistical evaluation of SAGE libraries: consequences for experimental design

    NARCIS (Netherlands)

    Ruijter, Jan M.; van Kampen, Antoine H. C.; Baas, Frank

    2002-01-01

    Since the introduction of serial analysis of gene expression (SAGE) as a method to quantitatively analyze the differential expression of genes, several statistical tests have been published for the pairwise comparison of SAGE libraries. Testing the difference between the number of specific tags

  17. A Geant4 simulation package for the SAGE spectrometer

    International Nuclear Information System (INIS)

    Papadakis, P; Cox, D M; Butler, P A; Herzberg, R-D; Pakarinen, J; Konki, J; Greenlees, P T; Hauschild, K; Rahkila, P; Sandzelius, M; Sorri, J

    2012-01-01

    A comprehensive Geant4 simulation was built for the SAGE spectrometer. The simulation package includes the silicon and germanium detectors, the mechanical structure and the electromagnetic fields present in SAGE. This simulation can be used for making predictions through simulating experiments and for comparing simulated and experimental data to better understand the underlying physics.

  18. Molecular insights into the biology of Greater Sage-Grouse

    Science.gov (United States)

    Oyler-McCance, Sara J.; Quinn, Thomas W.

    2011-01-01

    Recent research on Greater Sage-Grouse (Centrocercus urophasianus) genetics has revealed some important findings. First, multiple paternity in broods is more prevalent than previously thought, and leks do not comprise kin groups. Second, the Greater Sage-Grouse is genetically distinct from the congeneric Gunnison sage-grouse (C. minimus). Third, the Lyon-Mono population in the Mono Basin, spanning the border between Nevada and California, has unique genetic characteristics. Fourth, the previous delineation of western (C. u. phaios) and eastern Greater Sage-Grouse (C. u. urophasianus) is not supported genetically. Fifth, two isolated populations in Washington show indications that genetic diversity has been lost due to population declines and isolation. This chapter examines the use of molecular genetics to understand the biology of Greater Sage-Grouse for the conservation and management of this species and put it into the context of avian ecology based on selected molecular studies.

  19. Supporting Adolescents with Guidance and Employment (SAGE).

    Science.gov (United States)

    Ringwalt, C L; Graham, L A; Paschall, M J; Flewelling, R L; Browne, D C

    1996-01-01

    Supporting Adolescents with Guidance and Employment (SAGE) is a multifaceted, community-based violence-prevention program. Its target is African-American male adolescents in Durham, North Carolina. Public health professionals, county government officials, and local businessmen collaborated in its development and implementation. The program is based on the paradigm of risk and protective factors, in which various risk factors for youth violence are buffered by modifiable, protective psychosocial processes. SAGE includes an eight-month African-American Rites of Passage program (adult mentoring, African-American culture and history lessons, and manhood and conflict-resolution training), a six-week summer employment component, and a 12-week entrepreneurial experience. Of the 260 youth recruited, 88 were randomly assigned to receive all three program components, 85 were assigned to the summer employment and entrepreneurial components only, and 87 were assigned to a delayed program or control condition. We compared these three groups' psychosocial and behavioral outcomes using survey data and archival records. Program implementation data include attendance records; mentor-youth activity logs pre- and postprogram focus group discussions; and telephone interviews with parents, program staff, and participants. The mean age of the adolescents recruited into the program was 14. Half reported receiving free lunches at school; half were not living with a father; and one quarter reported that their mothers had not completed high school. During the previous year, many had engaged in various violence-related behaviors, including fighting (49%) and carrying a gun (22%). Youths in each program condition were similar with respect to key demographic and behavioral characteristics. The key components of the SAGE program represent increasingly popular but untested approaches. Preliminary results reveal that these youths are involved in violent behavior both as perpetrators and as

  20. The Soviet-American gallium experiment (SAGE)

    International Nuclear Information System (INIS)

    Garvey, G.T.

    1989-01-01

    The Soviet-American Gallium Experiment (SAGE) undertaking is a multi-institutional collaboration among scientists from the Institute for Nuclear Research, Moscow (INR), Los Alamos National Laboratory (LANL), and several US universities. It's purpose is to measure the number of low-energy electron neutrinos emitted from the Sun that arrive at this planet. As such, it is an extremely important experiment, touching on fundamental physics issues as well as solar dynamics. In contrast to the strategic overviews, plans, and hopes for intentional collaboration presented earlier today, SAGE is an ongoing working effort with high hopes of producing the first measurement of the Sun's low-energy flux. There are several international physics collaborations involving US and Soviet scientists at the large accelerator installations throughout the world. As the scale of research gets ever larger, requiring ever more resources and then larger collaborations. Much physics research lies solely in the realm of basic research so that governments feel easier about collaborations. Contacts between the US and USSR scientists interested in nuclear and particle physics goes back to the nineteen fifties and have continued with only minor interruptions since then. Over the past two decades the principal oversight of these activities has been through the Joint Coordinating Committee on the Fundamental Properties of Matter, supported by the DOE in the US and the State Committee for Atomic Energy in the USSR. The Academies of Science of both countries have been very helpful and supportive. Each venture has some distinguishing features; in the case of SAGE, the unique aspects are the collaboration between Soviet scientists and scientists at a DOE weapons laboratory and the fact that the experiment is carried out in a remote region of the USSR. The particular problems caused are discussed. 3 refs., 3 figs

  1. SAGE II measurements of early Pinatubo aerosols

    Science.gov (United States)

    Mccormick, M. P.; Veiga, R. E.

    1992-01-01

    SAGE II satellite measurements of the Mt. Pinatubo eruption cloud in the stratosphere during June, July, and early August 1991 show that aerosols in the tropics reached as high as 29 km altitude with most of the cloud between 20 and 25 km. The most optically thick portions of the cloud covered latitudes from 10 deg S to 30 deg N during the early part of this period. By late July, high stratospheric optical depths were observed to at least 70 deg N, with the high values north of about 30 deg N from layers below 20 km. High pressure systems in both hemispheres were observed to be correlated with the movement of volcanic material at 21 km into the westerly jet stream at high southern latitudes and similarly to high northern latitudes at 16 km. By August, the entire Southern Hemisphere had experienced a 10-fold increase in optical depth relative to early July due to layers above 20 km. Initial mass calculations using SAGE II data place the aerosol produced from this eruption at 20 to 30 megatons, well above the 12 megatons produced by El Chichon.

  2. Automatic Deduction in Dynamic Geometry using Sage

    Directory of Open Access Journals (Sweden)

    Francisco Botana

    2012-02-01

    Full Text Available We present a symbolic tool that provides robust algebraic methods to handle automatic deduction tasks for a dynamic geometry construction. The main prototype has been developed as two different worksheets for the open source computer algebra system Sage, corresponding to two different ways of coding a geometric construction. In one worksheet, diagrams constructed with the open source dynamic geometry system GeoGebra are accepted. In this worksheet, Groebner bases are used to either compute the equation of a geometric locus in the case of a locus construction or to determine the truth of a general geometric statement included in the GeoGebra construction as a boolean variable. In the second worksheet, locus constructions coded using the common file format for dynamic geometry developed by the Intergeo project are accepted for computation. The prototype and several examples are provided for testing. Moreover, a third Sage worksheet is presented in which a novel algorithm to eliminate extraneous parts in symbolically computed loci has been implemented. The algorithm, based on a recent work on the Groebner cover of parametric systems, identifies degenerate components and extraneous adherence points in loci, both natural byproducts of general polynomial algebraic methods. Detailed examples are discussed.

  3. Mass preserving image registration

    DEFF Research Database (Denmark)

    Gorbunova, Vladlena; Sporring, Jon; Lo, Pechin Chien Pau

    2010-01-01

    The paper presents results the mass preserving image registration method in the Evaluation of Methods for Pulmonary Image Registration 2010 (EMPIRE10) Challenge. The mass preserving image registration algorithm was applied to the 20 image pairs. Registration was evaluated using four different...

  4. Monoterpene synthases from common sage (Salvia officinalis)

    Energy Technology Data Exchange (ETDEWEB)

    Croteau, Rodney Bruce (Pullman, WA); Wise, Mitchell Lynn (Pullman, WA); Katahira, Eva Joy (Pullman, WA); Savage, Thomas Jonathan (Christchurch 5, NZ)

    1999-01-01

    cDNAs encoding (+)-bornyl diphosphate synthase, 1,8-cineole synthase and (+)-sabinene synthase from common sage (Salvia officinalis) have been isolated and sequenced, and the corresponding amino acid sequences has been determined. Accordingly, isolated DNA sequences (SEQ ID No:1; SEQ ID No:3 and SEQ ID No:5) are provided which code for the expression of (+)-bornyl diphosphate synthase (SEQ ID No:2), 1,8-cineole synthase (SEQ ID No:4) and (+)-sabinene synthase SEQ ID No:6), respectively, from sage (Salvia officinalis). In other aspects, replicable recombinant cloning vehicles are provided which code for (+)-bornyl diphosphate synthase, 1,8-cineole synthase or (+)-sabinene synthase, or for a base sequence sufficiently complementary to at least a portion of (+)-bornyl diphosphate synthase, 1,8-cineole synthase or (+)-sabinene synthase DNA or RNA to enable hybridization therewith. In yet other aspects, modified host cells are provided that have been transformed, transfected, infected and/or injected with a recombinant cloning vehicle and/or DNA sequence encoding (+)-bornyl diphosphate synthase, 1,8-cineole synthase or (+)-sabinene synthase. Thus, systems and methods are provided for the recombinant expression of the aforementioned recombinant monoterpene synthases that may be used to facilitate their production, isolation and purification in significant amounts. Recombinant (+)-bornyl diphosphate synthase, 1,8-cineole synthase and (+)-sabinene synthase may be used to obtain expression or enhanced expression of (+)-bornyl diphosphate synthase, 1,8-cineole synthase and (+)-sabinene synthase in plants in order to enhance the production of monoterpenoids, or may be otherwise employed for the regulation or expression of (+)-bornyl diphosphate synthase, 1,8-cineole synthase and (+)-sabinene synthase, or the production of their products.

  5. The Russian-American Gallium solar neutrino Experiment (SAGE)

    International Nuclear Information System (INIS)

    Bowles, T.J.

    1994-01-01

    The Russian-American Gallium Experiment (SAGE) began measurements of the integral flux of solar neutrinos using 30 tons of metallic gallium as the target in January 1990. The mass of the gallium was increased to 57 tons in September 1991 and SAGE began to count the decay of 71 Ge using both the K and L peaks in September 1992. The results indicate a deficit of about 40% of the flux predicted by the Standard Solar Model. The chemical extraction and counting techniques used by SAGE are presented, with particular attention on backgrounds. The present status, results, and future plans of SAGE are presented, along with a discussion of the possible physics implications

  6. Long SAGE analysis of genes differentially expressed in the midgut ...

    African Journals Online (AJOL)

    Long SAGE analysis of genes differentially expressed in the midgut and silk gland between the sexes of the silkwormBombyx mori. Liping Gan, Ying Wang, Jian Xi, Yanshan Niu, Hongyou Qin, Yanghu Sima, Shiqing Xu ...

  7. SAGE - MULTIDIMENSIONAL SELF-ADAPTIVE GRID CODE

    Science.gov (United States)

    Davies, C. B.

    1994-01-01

    SAGE, Self Adaptive Grid codE, is a flexible tool for adapting and restructuring both 2D and 3D grids. Solution-adaptive grid methods are useful tools for efficient and accurate flow predictions. In supersonic and hypersonic flows, strong gradient regions such as shocks, contact discontinuities, shear layers, etc., require careful distribution of grid points to minimize grid error and produce accurate flow-field predictions. SAGE helps the user obtain more accurate solutions by intelligently redistributing (i.e. adapting) the original grid points based on an initial or interim flow-field solution. The user then computes a new solution using the adapted grid as input to the flow solver. The adaptive-grid methodology poses the problem in an algebraic, unidirectional manner for multi-dimensional adaptations. The procedure is analogous to applying tension and torsion spring forces proportional to the local flow gradient at every grid point and finding the equilibrium position of the resulting system of grid points. The multi-dimensional problem of grid adaption is split into a series of one-dimensional problems along the computational coordinate lines. The reduced one dimensional problem then requires a tridiagonal solver to find the location of grid points along a coordinate line. Multi-directional adaption is achieved by the sequential application of the method in each coordinate direction. The tension forces direct the redistribution of points to the strong gradient region. To maintain smoothness and a measure of orthogonality of grid lines, torsional forces are introduced that relate information between the family of lines adjacent to one another. The smoothness and orthogonality constraints are direction-dependent, since they relate only the coordinate lines that are being adapted to the neighboring lines that have already been adapted. Therefore the solutions are non-unique and depend on the order and direction of adaption. Non-uniqueness of the adapted grid is

  8. Sage-grouse habitat selection during winter in Alberta

    Science.gov (United States)

    Carpenter, Jennifer L.; Aldridge, Cameron L.; Boyce, Mark S.

    2010-01-01

    Greater sage-grouse (Centrocercus urophasianus) are dependent on sagebrush (Artemisia spp.) for food and shelter during winter, yet few studies have assessed winter habitat selection, particularly at scales applicable to conservation planning. Small changes to availability of winter habitats have caused drastic reductions in some sage-grouse populations. We modeled winter habitat selection by sage-grouse in Alberta, Canada, by using a resource selection function. Our purpose was to 1) generate a robust winter habitat-selection model for Alberta sage-grouse; 2) spatially depict habitat suitability in a Geographic Information System to identify areas with a high probability of selection and thus, conservation importance; and 3) assess the relative influence of human development, including oil and gas wells, in landscape models of winter habitat selection. Terrain and vegetation characteristics, sagebrush cover, anthropogenic landscape features, and energy development were important in top Akaike's Information Criterionselected models. During winter, sage-grouse selected dense sagebrush cover and homogenous less rugged areas, and avoided energy development and 2-track truck trails. Sage-grouse avoidance of energy development highlights the need for comprehensive management strategies that maintain suitable habitats across all seasons. ?? 2010 The Wildlife Society.

  9. Greater Sage-Grouse (Centrocercus Urophasianus) Hen Survival: Effects of Raptors, Anthropogenic and Landscape Features, and Hen Behavior

    OpenAIRE

    Dinkins, Jonathan B.; Conover, Michael R.; Kirol, Christopher P.; Beck, Jeffrey L.; Frey, S. Nicole

    2014-01-01

    Survival of breeding-age hens has been identified as the demographic rate with the greatest potential to influence population growth of Greater Sage-Grouse (Centrocercus urophasianus (Bonaparte, 1827); hereafter “Sage-Grouse”). During 2008–2011, we collected summer survival data from 427 Sage-Grouse hens in southern Wyoming, USA. We assessed the effects of raptor densities, anthropogenic features, landscape features, and Sage-Grouse hen behavior on Sage-Grouse hen survival. Survival of Sage-G...

  10. Rock Equity Holdings, LLC

    Science.gov (United States)

    The EPA is providing notice of an Administrative Penalty Assessment in the form of an Expedited Storm Water Settlement Agreement against Rock Equity Holdings, LLC, for alleged violations at The Cove at Kettlestone/98th Street Reconstruction located at 3015

  11. Breath-Holding Spells

    Science.gov (United States)

    ... reviewed: October 2016 More on this topic for: Parents Is It Normal for Children to Hold Their Breath? Taming Tempers Disciplining Your Child Disciplining Your Toddler Temper Tantrums Separation Anxiety View more About Us Contact Us Partners ...

  12. Measurement of fast neutron background in SAGE

    CERN Document Server

    Abdurashitov, J N; Kalikhov, A V; Matushko, V L; Shikhin, A A; Yants, V E; Zaborskaia, O S

    2002-01-01

    The spectrometer intended for direct measurements of ultra low fluxes of fast neutrons is described. It is sensitive to neutron fluxes of 10 sup - sup 7 cm sup - sup 2 s sup - sup 1 and lower. The detection efficiency of fast neutrons with simultaneous energy measurement was determined from Monte-Carlo simulation to be equal to 0.11 +- 0.01. The background counting rate in the detector corresponds to a neutron flux of (6.5 +- 2.1) x 10 sup - sup 7 cm sup - sup 2 s sup - sup 1 in the range 1.0-11.0 MeV. The natural neutron flux from the surrounding mine rock at the depth of 4700 meters of water equivalent was measured to be (7.3 +- 2.4) x 10 sup - sup 7 cm sup - sup 2 s sup - sup 1 in the range 1.0-11.0 MeV. The flux of fast neutrons in the SAGE main room was measured to be < 2.3 x 10 sup - sup 7 cm sup - sup 2 s sup - sup 1 in 1.0-11.0 MeV energy range.

  13. Measurement of fast neutron background in SAGE

    International Nuclear Information System (INIS)

    Abdurashitov, J.N.; Gavrin, V.N.; Kalikhov, A.V.; Matushko, V.L.; Shikhin, A.A.; Yants, V.E.; Zaborskaia, O.S.

    2002-01-01

    The spectrometer intended for direct measurements of ultra low fluxes of fast neutrons is described. It is sensitive to neutron fluxes of 10 -7 cm -2 s -1 and lower. The detection efficiency of fast neutrons with simultaneous energy measurement was determined from Monte-Carlo simulation to be equal to 0.11 ± 0.01. The background counting rate in the detector corresponds to a neutron flux of (6.5 ± 2.1) x 10 -7 cm -2 s -1 in the range 1.0-11.0 MeV. The natural neutron flux from the surrounding mine rock at the depth of 4700 meters of water equivalent was measured to be (7.3 ± 2.4) x 10 -7 cm -2 s -1 in the range 1.0-11.0 MeV. The flux of fast neutrons in the SAGE main room was measured to be -7 cm -2 s -1 in 1.0-11.0 MeV energy range

  14. Stratospheric ozone profile and total ozone trends derived from the SAGE I and SAGE II data

    Science.gov (United States)

    Mccormick, M. P.; Veiga, Robert E.; Chu, William P.

    1992-01-01

    Global trends in both stratospheric column ozone and as a function of altitude are derived on the basis of SAGE I/II ozone data from the period 1979-1991. A statistical model containing quasi-biennial, seasonal, and semiannual oscillations, a linear component, and a first-order autoregressive noise process was fit to the time series of SAGE I/II monthly zonal mean data. The linear trend in column ozone above 17-km altitude, averaged between 65 deg S and 65 deg N, is -0.30 +/-0.19 percent/yr, or -3.6 percent over the time period February 1979 through April 1991. The data show that the column trend above 17 km is nearly zero in the tropics and increases towards the high latitudes with values of -0.6 percent/yr at 60 deg S and -0.35 percent/yr at 60 deg N. Both these results are in agreement with the recent TOMS results. The profile trend analyses show that the column ozone losses are occurring below 25 km, with most of the loss coming from the region between 17 and 20 km. Negative trend values on the order of -2 percent/yr are found at 17 km in midlatitudes.

  15. Four Intoxication Cases Related to the Misuse of Sage Oil

    Directory of Open Access Journals (Sweden)

    Suzan Gündüz

    2016-06-01

    Full Text Available Infantile colic is excessive crying of infants younger than 4 months. Families of children suffering from infantile colic attend to the emergency department frequently and the etiology is not well-known. However many families of chil­dren suffering from infantile colic try pharmacologic and non-pharmacologic treatment, they are sleepless and ex­hausted and are affected negatively. Sage oil is in volatile form and it is recommended to apply 1-2 drops on plantar and tummy region of the body by massage for the treat­ment of infantile colic. Most of drugs used for infantile colic are drops and used orally. Families who do not learn detailed usage information may use it orally or may pre­sumed another drug while suffering from sleepless and drowsiness. Herein we reported 4 cases of sage oil intoxi­cation because of wrong information of wrong application of sage oil. We aimed to reduce the prescribing of sage oil in the treatment of infantile colic and emphasize to give more information about proper use of sage oil.

  16. Nesting success and resource selection of Greater Sage-Grouse [chapter 8

    Science.gov (United States)

    Nicholas W. Kaczor; Kent C. Jensen; Robert W. Klaver; Mark A. Rumble; Katie M. Herman-Brunson; Christopher C. Swanson

    2011-01-01

    Declines of Greater Sage-Grouse (Centrocercus urophasianus) in South Dakota are a concern because further population declines may lead to isolation from populations in Wyoming and Montana. Furthermore, little information exists about reproductive ecology and resource selection of sage grouse on the eastern edge of their distribution. We investigated Greater Sage-Grouse...

  17. 78 FR 65936 - Endangered and Threatened Wildlife and Plants; Proposed Endangered Status for Gunnison Sage...

    Science.gov (United States)

    2013-11-04

    ... and Plants; Proposed Endangered Status for Gunnison Sage-Grouse and Proposed Designation of Critical Habitat for Gunnison Sage-Grouse AGENCY: Fish and Wildlife Service, Interior. ACTION: Proposed rule... rules to list the Gunnison sage-grouse (Centrocercus minimus) as endangered and to designate critical...

  18. 78 FR 2539 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Gunnison Sage...

    Science.gov (United States)

    2013-01-11

    ... Gunnison Sage-Grouse; Proposed Rule #0;#0;Federal Register / Vol. 78 , No. 8 / Friday, January 11, 2013...; Designation of Critical Habitat for Gunnison Sage-Grouse AGENCY: Fish and Wildlife Service, Interior. ACTION... the Gunnison sage-grouse (Centrocercus minimus) under the Endangered Species Act of 1973, as amended...

  19. Lek ecology of male greater sage-grouse in Carbon County, Wyoming

    Science.gov (United States)

    Aleshia Lynn Fremgen

    2014-01-01

    Greater sage-grouse (Centrocercus urophasianus, hereafter "sage-grouse") have experienced range-wide population declines for several decades, and as a result they were considered warranted for listing under the Endangered Species Act in 2010. Therefore, wildlife managers need to understand how sage-grouse breeding behavior influences long-term reproductive...

  20. Resource selection during brood-rearing by Greater Sage-Grouse [chapter 12

    Science.gov (United States)

    Nicholas W. Kaczor; Katie M. Herman-Brunson; Kent C. Jensen; Mark A. Rumble; Robert W. Klaver; Christopher C. Swanson

    2011-01-01

    Understanding population dynamics and resource selection is crucial in developing wildlife resource management plans for sensitive species such as Greater Sage-Grouse (Centrocercus urophasianus). Little is known about sage grouse habitats on the eastern edge of their range. We investigated resource selection of Greater Sage-Grouse during brood- rearing in North and...

  1. An overview af SAGE I and II ozone measurements

    Science.gov (United States)

    Mccormick, M. P.; Zawodny, J. M.; Veiga, R. E.; Larsen, J. C.; Wang, P. H.

    1989-01-01

    The stratospheric Aerosol and Gas Experiments (SAGE) I and II measure Mie, Rayleigh, and gaseous extinction profiles using the solar occultation technique. These global measurements yield ozone profiles with a vertical resolution of 1 km which have been routinely obtained for the periods from February 1979 to November 1981 (SAGE I) and October 1984 to the present (SAGE II). The long-term periodic behavior of the measured ozone is presented as well as case studies of the observed short-term spatial and temporal variability. A linear regression shows annual, semiannual, and quasi-biennial oscillation features at various altitudes and latitudes which, in general, agree with past work. Also, ozone, aerosol, and water vapor data are described for the Antarctic springtime, showing large variation relative to the vortex. Cross-sections in latitude and altitude and polar plots at various altitudes clearly delineate the ozone hole vertically and areally.

  2. Tube holding system

    International Nuclear Information System (INIS)

    Cunningham, R.C.

    1978-01-01

    A tube holding rig is described for the lateral support of tubes arranged in tight parcels in a heat exchanger. This tube holding rig includes not less than two tube supporting assemblies, with a space between them, located crosswise with respect to the tubes, each supporting assembly comprising a first set of parallel components in contact with the tubes, whilst a second set of components is also in contact with the tubes. These two sets of parts together define apertures through which the tubes pass [fr

  3. How do SAGES members rate its guidelines?

    Science.gov (United States)

    Hope, William W; Richardson, William; Fanelli, Robert; Stefanidis, Dimitrios

    2014-04-01

    The development of practice guidelines should take into consideration the opinions of end users. The Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) has implemented several changes in its guideline development and dissemination process based on previous end-user input. An anonymous electronic survey was conducted via e-mail solicitation in September 2011. Respondents were asked to submit their feedback on the 26 guidelines produced by our society using a 32-item questionnaire and to suggest topics for new guideline development and areas of improvement. Responses from the survey were received by 494 people, of whom 474 (96 %) were clinicians; 373 (75 %) were general, laparoscopic, or bariatric surgeons; and 324 (65 %) held leadership roles within their institution. Most respondents were 35-44 years old (36 %), male (83 %), and had been in practice for over 10 years (54 %). A total of 383 (81 %) had used our guidelines, and, of those, 96 % agreed with their content. Guideline quality was rated 4.34; value 4.27; and ease of access 3.97 on a five-point Likert scale. The most commonly referenced guideline in the survey regarded surgical treatment of reflux (67 %), followed by laparoscopy during pregnancy (51 %). The three most common reasons guidelines were accessed were to update knowledge (68 %), to maximize patient care through evidence-based treatment (51 %), and to obtain a critical literature review. The majority of respondents indicated they greatly value and agree with our guidelines. These results indicate that recent efforts to improve our guidelines have succeeded.

  4. Registration of Space Objects

    Science.gov (United States)

    Schmidt-Tedd, Bernhard

    2017-07-01

    Space objects are subject to registration in order to allocate "jurisdiction and control" over those objects in the sovereign-free environment of outer space. This approach is similar to the registration of ships in view of the high sea and for aircrafts with respect to the international airspace. Registration is one of the basic principles of space law, starting with UN General Assembly Resolution 1721 B (XVI) of December 20, 1961, followed by Resolution 1962 (XVIII) of December 13, 1963, then formulated in Article VIII of the Outer Space Treaty of 1967 and as specified in the Registration Convention of 1975. Registration of space objects can be seen today as a principle of customary international law, relevant for each spacefaring state. Registration is divided into a national and an international level. The State Party establishes a national registry for its space objects, and those registrations have to be communicated via diplomatic channel to the UN Register of space objects. This UN Register is handled by the UN Office for Outer Space Affairs (UNOOSA) and is an open source of information for space objects worldwide. Registration is linked to the so-called launching state of the relevant space object. There might be more than one launching state for the specific launch event, but only one state actor can register a specific space object. The state of registry gains "jurisdiction and control" over the space object and therefore no double registration is permissible. Based on the established UN Space Law, registration practice was subject to some adaptions due to technical developments and legal challenges. After the privatization of the major international satellite organizations, a number of non-registrations had to be faced. The state actors reacted with the UN Registration Practice Resolution of 2007 as elaborated in the Legal Subcommittee of UNCOPUOS, the Committee for the Peaceful Use of Outer Space. In this context an UNOOSA Registration Information

  5. SAGE 2.0 SOLVENT ALTERNATIVES GUIDE - USER'S GUIDE

    Science.gov (United States)

    The guide provides instruction for using the SAGE (Solvent Alternatives Guide) software system, version 2.O. It assumes that the user is familiar with the fundamentals of operating a personal computer under the Microsoft disk operating system (MS-DOS). AGE recommends solvent repl...

  6. Male greater sage-grouse detectability on leks

    Science.gov (United States)

    Aleshia L. Fremgen; Christopher P. Hansen; Mark A. Rumble; R. Scott Gamo; Joshua J. Millspaugh

    2016-01-01

    It is unlikely all male sage-grouse are detected during lek counts, which could complicate the use of lek counts as an index to population abundance. Understanding factors that influence detection probabilities will allow managers to more accurately estimate the number of males present on leks. We fitted 410 males with global positioning system and very high...

  7. USDA Forest Service Sage-Grouse Conservation Science Strategy

    Science.gov (United States)

    Deborah Finch; Douglas Boyce; Jeanne Chambers; Chris Colt; Clint McCarthy; Stanley Kitchen; Bryce Richardson; Mary Rowland; Mark Rumble; Michael Schwartz; Monica Tomosy; Michael Wisdom

    2015-01-01

    Numerous federal and state agencies, research institutions and stakeholders have undertaken tremendous conservation and research efforts across 11 States in the western United States to reduce threats to Greater Sage-Grouse (Centrocercus urophasianus) and sagebrush (Artemisia spp) habitats. In 2010, the U.S. Fish and Wildlife Service (USFWS) determined that the Greater...

  8. Inhibitory effect of aromatic herbs, lavender, sage and chamomile ...

    African Journals Online (AJOL)

    This study demonstrated anti-herpes simplex virus (HSV) activity of lavender, sage and chamomile extracts. Green monkey kidney cells were protected from HSV-2 infection by dichloromethane and methanol extract of lavender with therapeutic indices (TI) of 1.98 and 2.90, respectively when the cells were treated before ...

  9. Composition of the essential oil of White sage, Salvia apiana.

    Energy Technology Data Exchange (ETDEWEB)

    Hochrein, James Michael; Irwin, Adriane Nadine; Borek, Theodore Thaddeus, III

    2003-08-01

    The essential oil of white sage, Salvia apiana, was obtained by steam distillation and analysed by GC-MS. A total of 13 components were identified, accounting for >99.9% of the oil. The primary component was 1,8-cineole, accounting for 71.6% of the oil.

  10. Effect of sage extract ( Salvia officinalis ) on growth performance ...

    African Journals Online (AJOL)

    This study was performed to evaluate the effect of different doses of sage extract on the growth and blood parameters, oxidative stress and DNA damage in partridges. In total, 252 day-old partridges (Alectoris chukar) were used. The birds were divided into four groups: 0.1% flavomycin was included in the diet of the control ...

  11. Breath-Hold Diving.

    Science.gov (United States)

    Fitz-Clarke, John R

    2018-03-25

    Breath-hold diving is practiced by recreational divers, seafood divers, military divers, and competitive athletes. It involves highly integrated physiology and extreme responses. This article reviews human breath-hold diving physiology beginning with an historical overview followed by a summary of foundational research and a survey of some contemporary issues. Immersion and cardiovascular adjustments promote a blood shift into the heart and chest vasculature. Autonomic responses include diving bradycardia, peripheral vasoconstriction, and splenic contraction, which help conserve oxygen. Competitive divers use a technique of lung hyperinflation that raises initial volume and airway pressure to facilitate longer apnea times and greater depths. Gas compression at depth leads to sequential alveolar collapse. Airway pressure decreases with depth and becomes negative relative to ambient due to limited chest compliance at low lung volumes, raising the risk of pulmonary injury called "squeeze," characterized by postdive coughing, wheezing, and hemoptysis. Hypoxia and hypercapnia influence the terminal breakpoint beyond which voluntary apnea cannot be sustained. Ascent blackout due to hypoxia is a danger during long breath-holds, and has become common amongst high-level competitors who can suppress their urge to breathe. Decompression sickness due to nitrogen accumulation causing bubble formation can occur after multiple repetitive dives, or after single deep dives during depth record attempts. Humans experience responses similar to those seen in diving mammals, but to a lesser degree. The deepest sled-assisted breath-hold dive was to 214 m. Factors that might determine ultimate human depth capabilities are discussed. © 2018 American Physiological Society. Compr Physiol 8:585-630, 2018. Copyright © 2018 American Physiological Society. All rights reserved.

  12. Changes in salivary oxytocin after inhalation of clary sage essential oil scent in term-pregnant women: a feasibility pilot study.

    Science.gov (United States)

    Tadokoro, Yuriko; Horiuchi, Shigeko; Takahata, Kaori; Shuo, Takuya; Sawano, Erika; Shinohara, Kazuyuki

    2017-12-08

    This pilot study using a quasi-experimental design was conducted to evaluate the feasibility (i.e., limited efficacy, practicality, and acceptability) of our intervention protocol involving inhalation of the scent of clary sage essential oil by pregnant women and measurement of their preinhalation and postinhalation oxytocin levels. Participants were women of singleton pregnancies between 38 and 40 gestation weeks (N = 11). The experiment group (n = 5) inhaled the scent of clary sage essential oil diluted 50-fold with 10 mL of odorless propylene glycol for 20 min. Regarding limited efficacy, the oxytocin level 15 min postinhalation increased in 3 women and was unmeasurable in 2. The control group (n = 6) inhaled similarly without the 50-fold dilution of clary sage essential oil. Their oxytocin level increased in 2 women, decreased in 2, and was unmeasurable in 2. Uterine contraction was not observed in both groups. Regarding practicality, 3 of the 11 women could not collect sufficient saliva. The cortisol level decreased in both groups postinhalation. The protocol had no negative effects. Regarding acceptability, burden of the protocol was not observed. Trial registration The Clinical Trials Registry of University Hospital Medical Information Network in Japan-UMIN000017830. Registered:  June 8, 2015.

  13. Field Geophysics at SAGE: Strategies for Effective Education

    Science.gov (United States)

    Braile, L. W.; Baldridge, W. S.; Jiracek, G. R.; Biehler, S.; Ferguson, J. F.; Pellerin, L.; McPhee, D. K.; Bedrosian, P. A.; Snelson, C. M.; Hasterok, D. P.

    2011-12-01

    SAGE (Summer of Applied Geophysical Experience) is a unique program of education and research in geophysical field methods for undergraduate and graduate students from any university and for professionals. The core program is held for 4 weeks each summer in New Mexico and for an additional week in the following academic year in San Diego for U.S. undergraduates supported by the NSF Research Experience for Undergraduates (REU) program. Since SAGE was initiated in 1983, 730 students have participated in the program. NSF REU funding for SAGE began in 1990 and 319 REU students have completed SAGE through 2011. The primary objectives of SAGE are to teach the major geophysical exploration methods (seismic, gravity, magnetics, electromagnetics); apply these methods to the solution of specific problems (environmental, archaeological, hydrologic, geologic structure and stratigraphy); gain experience in processing, modeling and interpretation of geophysical data; and integrate the geophysical models and interpretations with geology. Additional objectives of SAGE include conducting research on the Rio Grande rift of northern New Mexico, and providing information on geophysics careers and professional development experiences to SAGE participants. Successful education, field and research strategies that we have implemented over the years include: 1. learn by doing; 2. mix lecture/discussion, field work, data processing and analysis, modeling and interpretation, and presentation of results; 3. a two-tier team approach - method/technique oriented teams and interpretation/integration teams (where each team includes persons representing different methods), provides focus, in-depth study, opportunity for innovation, and promotes teamwork and a multi-disciplinary approach; 4. emphasis on presentations/reports - each team (and all team members) make presentation, each student completes a written report; 5. experiment design discussion - students help design field program and consider

  14. Locally orderless registration code

    DEFF Research Database (Denmark)

    2012-01-01

    This is code for the TPAMI paper "Locally Orderless Registration". The code requires intel threadding building blocks installed and is provided for 64 bit on mac, linux and windows.......This is code for the TPAMI paper "Locally Orderless Registration". The code requires intel threadding building blocks installed and is provided for 64 bit on mac, linux and windows....

  15. SAGES climate survey: results and strategic planning for our future.

    Science.gov (United States)

    Telem, Dana A; Qureshi, Alia; Edwards, Michael; Jones, Daniel B

    2018-03-30

    While SAGES prides itself on diversity and inclusivity, we also recognize that as an organization we are not impervious to blind spots impacting equity within the membership. To address this, the We R Sages task force was formed to identify the barriers and facilitators to creating a diverse organization and develop a strategic plan for the implementation of programing and opportunities that promote diversity and inclusivity within our membership. As the first step in the process, a survey was administered to gauge the current organizational climate. In September of 2017, a validated climate survey was administered to 704 SAGES committee members via SurveyMonkey®. Climate was assessed on: overall SAGES experience, consideration of leaving the organization, mentorship within the organization, resources and opportunities within the organization, and attitudes and experiences within the organization. Additional free text responses were encouraged to generate qualitative themes. The survey response rate was 52.1% (n = 367). Respondent self-identified demographics were: male (73%), white (63%), heterosexual (95.5%), and non-disabled (98%). Average overall satisfaction was 8.1/10. 12.5% of respondents had considered leaving the organization and 74.4% had not identified a formal mentor within the organization. Average agreement with equitable distribution of resources and opportunities was 5.8/10. 93.6% of respondents had not experienced bias within the organization. Overall SAGES has a very positive climate; however, several key issues were identified from the quantitative survey as well as the free text responses. Strategic planning to address issues of membership recruitment, committee engagement, advancement transparency, diversity awareness, leadership development, and formal mentorship are being implemented.

  16. Information from the Registration Service

    CERN Multimedia

    GS Department

    2011-01-01

    Please note that the Registration Service (Bldg 55-1st floor) will be exceptionally open during the annual end of year closure from 10:00 to 12:00 on the following days: 22, 23, 26, 27,28, 29 et 30 December 2011 and 2,3, et 4 January 2012. All the activities related to the Registration Service will be operational: registration for contractors’ personnel; registrations for professional visits; access cards; car stickers; biometric registration. The Registration Service

  17. Development of 13 microsatellites for Gunnison Sage-grouse (Centrocercus minimus) using next-generation shotgun sequencing and their utility in Greater Sage-grouse (Centrocercus urophasianus)

    Science.gov (United States)

    Fike, Jennifer A.; Oyler-McCance, Sara J.; Zimmerman, Shawna J; Castoe, Todd A.

    2015-01-01

    Gunnison Sage-grouse are an obligate sagebrush species that has experienced significant population declines and has been proposed for listing under the U.S. Endangered Species Act. In order to examine levels of connectivity among Gunnison Sage-grouse leks, we identified 13 novel microsatellite loci though next-generation shotgun sequencing, and tested them on the closely related Greater Sage-grouse. The number of alleles per locus ranged from 2 to 12. No loci were found to be linked, although 2 loci revealed significant departures from Hardy–Weinberg equilibrium or evidence of null alleles. While these microsatellites were designed for Gunnison Sage-grouse, they also work well for Greater Sage-grouse and could be used for numerous genetic questions including landscape and population genetics.

  18. hSAGEing: an improved SAGE-based software for identification of human tissue-specific or common tumor markers and suppressors.

    Science.gov (United States)

    Yang, Cheng-Hong; Chuang, Li-Yeh; Shih, Tsung-Mu; Chang, Hsueh-Wei

    2010-12-17

    SAGE (serial analysis of gene expression) is a powerful method of analyzing gene expression for the entire transcriptome. There are currently many well-developed SAGE tools. However, the cross-comparison of different tissues is seldom addressed, thus limiting the identification of common- and tissue-specific tumor markers. To improve the SAGE mining methods, we propose a novel function for cross-tissue comparison of SAGE data by combining the mathematical set theory and logic with a unique "multi-pool method" that analyzes multiple pools of pair-wise case controls individually. When all the settings are in "inclusion", the common SAGE tag sequences are mined. When one tissue type is in "inclusion" and the other types of tissues are not in "inclusion", the selected tissue-specific SAGE tag sequences are generated. They are displayed in tags-per-million (TPM) and fold values, as well as visually displayed in four kinds of scales in a color gradient pattern. In the fold visualization display, the top scores of the SAGE tag sequences are provided, along with cluster plots. A user-defined matrix file is designed for cross-tissue comparison by selecting libraries from publically available databases or user-defined libraries. The hSAGEing tool provides a combination of friendly cross-tissue analysis and an interface for comparing SAGE libraries for the first time. Some up- or down-regulated genes with tissue-specific or common tumor markers and suppressors are identified computationally. The tool is useful and convenient for in silico cancer transcriptomic studies and is freely available at http://bio.kuas.edu.tw/hSAGEing.

  19. hSAGEing: an improved SAGE-based software for identification of human tissue-specific or common tumor markers and suppressors.

    Directory of Open Access Journals (Sweden)

    Cheng-Hong Yang

    Full Text Available BACKGROUND: SAGE (serial analysis of gene expression is a powerful method of analyzing gene expression for the entire transcriptome. There are currently many well-developed SAGE tools. However, the cross-comparison of different tissues is seldom addressed, thus limiting the identification of common- and tissue-specific tumor markers. METHODOLOGY/PRINCIPAL FINDINGS: To improve the SAGE mining methods, we propose a novel function for cross-tissue comparison of SAGE data by combining the mathematical set theory and logic with a unique "multi-pool method" that analyzes multiple pools of pair-wise case controls individually. When all the settings are in "inclusion", the common SAGE tag sequences are mined. When one tissue type is in "inclusion" and the other types of tissues are not in "inclusion", the selected tissue-specific SAGE tag sequences are generated. They are displayed in tags-per-million (TPM and fold values, as well as visually displayed in four kinds of scales in a color gradient pattern. In the fold visualization display, the top scores of the SAGE tag sequences are provided, along with cluster plots. A user-defined matrix file is designed for cross-tissue comparison by selecting libraries from publically available databases or user-defined libraries. CONCLUSIONS/SIGNIFICANCE: The hSAGEing tool provides a combination of friendly cross-tissue analysis and an interface for comparing SAGE libraries for the first time. Some up- or down-regulated genes with tissue-specific or common tumor markers and suppressors are identified computationally. The tool is useful and convenient for in silico cancer transcriptomic studies and is freely available at http://bio.kuas.edu.tw/hSAGEing.

  20. JALFHCC - Patient Registration Service

    Data.gov (United States)

    Department of Veterans Affairs — The Captain James A. Lovell Federal Health Care Center (JALFHCC) Patient Registration Service supports the operation of the first VA/Navy Federal Health Care Center...

  1. Visitor Registration System

    Data.gov (United States)

    US Agency for International Development — Visitor Registration System (VRS) streamlines visitor check-in and check-out process for expediting visitors into USAID. The system captures visitor information...

  2. Pesticide Registration Information System

    Data.gov (United States)

    U.S. Environmental Protection Agency — PRISM provides an integrated, web portal for all pesticide related data, communications, registrations and transactions for OPP and its stakeholders, partners and...

  3. Registration of the cancer

    International Nuclear Information System (INIS)

    Morales, F.; Campos, X.

    2002-01-01

    A database for the registration of the cancer was designed in ambient access, of the Microsoft Office, to take the registrations at national level. With this database the statistics will be obtained about the incidence of the cancer in the population, evaluation of the sanitary services of prevention, diagnose and treatment of the illness, etc. The used codes are according to the listings of code of the Ministry of Health (MINSA) and OPS

  4. Determination of absolute internal conversion coefficients using the SAGE spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Sorri, J., E-mail: juha.m.t.sorri@jyu.fi [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); Greenlees, P.T.; Papadakis, P.; Konki, J. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); Cox, D.M. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); Department of Physics, University of Liverpool, Oxford Street, Liverpool L69 7ZE (United Kingdom); Auranen, K.; Partanen, J.; Sandzelius, M.; Pakarinen, J.; Rahkila, P.; Uusitalo, J. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); Herzberg, R.-D. [Department of Physics, University of Liverpool, Oxford Street, Liverpool L69 7ZE (United Kingdom); Smallcombe, J.; Davies, P.J.; Barton, C.J.; Jenkins, D.G. [Department of Physics, University of York, Heslington, York YO10 5DD (United Kingdom)

    2016-03-11

    A non-reference based method to determine internal conversion coefficients using the SAGE spectrometer is carried out for transitions in the nuclei of {sup 154}Sm, {sup 152}Sm and {sup 166}Yb. The Normalised-Peak-to-Gamma method is in general an efficient tool to extract internal conversion coefficients. However, in many cases the required well-known reference transitions are not available. The data analysis steps required to determine absolute internal conversion coefficients with the SAGE spectrometer are presented. In addition, several background suppression methods are introduced and an example of how ancillary detectors can be used to select specific reaction products is given. The results obtained for ground-state band E2 transitions show that the absolute internal conversion coefficients can be extracted using the methods described with a reasonable accuracy. In some cases of less intense transitions only an upper limit for the internal conversion coefficient could be given.

  5. Determination of absolute internal conversion coefficients using the SAGE spectrometer

    International Nuclear Information System (INIS)

    Sorri, J.; Greenlees, P.T.; Papadakis, P.; Konki, J.; Cox, D.M.; Auranen, K.; Partanen, J.; Sandzelius, M.; Pakarinen, J.; Rahkila, P.; Uusitalo, J.; Herzberg, R.-D.; Smallcombe, J.; Davies, P.J.; Barton, C.J.; Jenkins, D.G.

    2016-01-01

    A non-reference based method to determine internal conversion coefficients using the SAGE spectrometer is carried out for transitions in the nuclei of "1"5"4Sm, "1"5"2Sm and "1"6"6Yb. The Normalised-Peak-to-Gamma method is in general an efficient tool to extract internal conversion coefficients. However, in many cases the required well-known reference transitions are not available. The data analysis steps required to determine absolute internal conversion coefficients with the SAGE spectrometer are presented. In addition, several background suppression methods are introduced and an example of how ancillary detectors can be used to select specific reaction products is given. The results obtained for ground-state band E2 transitions show that the absolute internal conversion coefficients can be extracted using the methods described with a reasonable accuracy. In some cases of less intense transitions only an upper limit for the internal conversion coefficient could be given.

  6. Serial analysis of gene expression (SAGE) in rat liver regeneration

    International Nuclear Information System (INIS)

    Cimica, Velasco; Batusic, Danko; Haralanova-Ilieva, Borislava; Chen, Yonglong; Hollemann, Thomas; Pieler, Tomas; Ramadori, Giuliano

    2007-01-01

    We have applied serial analysis of gene expression for studying the molecular mechanism of the rat liver regeneration in the model of 70% partial hepatectomy. We generated three SAGE libraries from a normal control liver (NL library: 52,343 tags), from a sham control operated liver (Sham library: 51,028 tags), and from a regenerating liver (PH library: 53,061 tags). By SAGE bioinformatics analysis we identified 40 induced genes and 20 repressed genes during the liver regeneration. We verified temporal expression of such genes by real time PCR during the regeneration process and we characterized 13 induced genes and 3 repressed genes. We found connective tissue growth factor transcript and protein induced very early at 4 h after PH operation before hepatocytes proliferation is triggered. Our study suggests CTGF as a growth factor signaling mediator that could be involved directly in the mechanism of liver regeneration induction

  7. Sage-Grouse and Wind Energy: Biology, Habits, and Potential Effects from Development

    Energy Technology Data Exchange (ETDEWEB)

    Becker, James M.; Tagestad, Jerry D.; Duberstein, Corey A.; Downs, Janelle L.

    2009-07-15

    Proposed development of domestic energy resources, including wind energy, is expected to impact the sagebrush steppe ecosystem in the western United States. The greater sage-grouse relies on habitats within this ecosystem for survival, yet very little is known about how wind energy development may affect sage-grouse. The purpose of this report is to inform organizations of the impacts wind energy development could have on greater sage-grouse populations and identify information needed to fill gaps in knowledge.

  8. Smart and Green Energy (SAGE) for Base Camps Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Engels, Matthias; Boyd, Paul A.; Koehler, Theresa M.; Goel, Supriya; Sisk, Daniel R.; Hatley, Darrel D.; Mendon, Vrushali V.; Hail, John C.

    2014-02-11

    The U.S. Army Logistics Innovation Agency’s (LIA’s) Smart and Green Energy (SAGE) for Base Camps project was to investigate how base camps’ fuel consumption can be reduced by 30% to 60% using commercial off-the-shelf (COTS) technologies for power generation, renewables, and energy efficient building systems. Field tests and calibrated energy models successfully demonstrated that the fuel reductions are achievable.

  9. Interspecific nest parasitism by chukar on greater sage-grouse

    Science.gov (United States)

    Fearon, Michelle L.; Coates, Peter S.

    2014-01-01

    Nest parasitism occurs when a female bird lays eggs in the nest of another and the host incubates the eggs and may provide some form of parental care for the offspring (Lyon and Eadie 1991). Precocial birds (e.g., Galliformes and Anseriformes) are typically facultative nest parasites of both their own and other species (Lyon and Eadie 1991). This behavior increases a female’s reproductive success when she parasitizes other nests while simultaneously raising her own offspring. Both interspecific and conspecific nest parasitism have been well documented in several families of the order Galliformes, particularly the Phasianidae (Lyon and Eadie 1991, Geffen and Yom-Tov 2001, Krakauer and Kimball 2009). The Chukar (Alectoris chukar) has been widely introduced as a game bird to western North America from Eurasia and is now well established within the Great Basin from northeastern California east to Utah and north to Idaho and Oregon (Christensen 1996). Over much of this range the Chukar occurs with other phasianids, including the native Greater Sage-Grouse (Centrocercus urophasianus), within sagebrush (Artemisia spp.) steppe (Christensen 1996, Schroeder et al. 1999, Connelly et al. 2000). Chukar typically exploit a broader range of habitats than do sage-grouse, but both species use the same species of sagebrush and other shrubs for nesting cover (Christensen 1996, Schroeder et al. 1999). Chukar are known to parasitize nests of other individuals of their own species (Geffen and Yom-Tov 2001), but we are unaware of reported evidence that Chukar may parasitize nests of sage-grouse. Here we describe a case of a Chukar parasitizing a sage-grouse nest in the sagebrush steppe of western Nevada.

  10. The historical distribution of Gunnison Sage-Grouse in Colorado

    Science.gov (United States)

    Braun, Clait E.; Oyler-McCance, Sara J.; Nehring, Jennifer A.; Commons, Michelle L.; Young, Jessica R.; Potter, Kim M.

    2014-01-01

    The historical distribution of Gunnison Sage-Grouse (Centrocercus minimus) in Colorado is described based on published literature, observations, museum specimens, and the known distribution of sagebrush (Artemisia spp.). Historically, Gunnison Sage-Grouse were widely but patchily distributed in up to 22 counties in south-central and southwestern Colorado. The historical distribution of this species was south of the Colorado-Eagle river drainages primarily west of the Continental Divide. Potential contact areas with Greater Sage-Grouse (C. urophasianus) were along the Colorado-Eagle river system in Mesa, Garfield, and Eagle counties, west of the Continental Divide. Gunnison Sage-Grouse historically occupied habitats that were naturally highly fragmented by forested mountains and plateaus/mesas, intermountain basins without robust species of sagebrush, and river systems. This species adapted to use areas with more deciduous shrubs (i.e., Quercus spp., Amelanchier spp., Prunus spp.) in conjunction with sagebrush. Most areas historically occupied were small, linear, and patchily distributed within the overall landscape matrix. The exception was the large intermountain basin in Gunnison, Hinsdale, and Saguache counties. The documented distribution east of the Continental Divide within the large expanse of the San Luis Valley (Alamosa, Conejos, Costilla, and Rio Grande counties) was minimal and mostly on the eastern, northern, and southern fringes. Many formerly occupied habitat patches were vacant by the mid 1940s with extirpations continuing to the late 1990s. Counties from which populations were recently extirpated include Archuleta and Pitkin (1960s), and Eagle, Garfield, Montezuma, and Ouray (1990s).

  11. SAGES's advanced GI/MIS fellowship curriculum pilot project.

    Science.gov (United States)

    Weis, Joshua J; Goldblatt, Matthew; Pryor, Aurora; Dunkin, Brian J; Brunt, L Michael; Jones, Daniel B; Scott, Daniel J

    2018-06-01

    The American health care system faces deficits in quality and quantity of surgeons. SAGES is a major stakeholder in surgical fellowship training and is responsible for defining the curriculum for the Advanced GI/MIS fellowship. SAGES leadership is actively adapting this curriculum. The process of reform began in 2014 through a series of iterative meetings and discussions. A working group within the Resident and Fellow Training Committee reviewed case log data from 2012 to 2015. These data were used to propose new criteria designed to provide adequate exposure to core content. The working group also proposed using video assessment of an MIS case to provide objective assessment of competency. Case log data were available for 326 fellows with a total of 85,154 cases logged (median 227 per fellow). The working group proposed new criteria starting with minimum case volumes for five defined categories including foregut (20), bariatrics (25), inguinal hernia (10), ventral hernia (10), and solid organ/colon/thoracic (10). Fellows are expected to perform an additional 75 complex MIS cases of any category for a total of 150 required cases overall. The proposal also included a minimum volume of flexible endoscopy (50) and submission of an MIS foregut case for video assessment. The new criteria more clearly defined which surgeon roles count for major credit within individual categories. Fourteen fellowships volunteered to pilot these new criteria for the 2017-2018 academic year. The new SAGES Advanced GI/MIS fellowship has been crafted to better define the core content that should be contained in these fellowships, while still allowing sufficient heterogeneity so that individual learners can tailor their training to specific areas of interest. The criteria also introduce innovative, evidence-based methods for assessing competency. Pending the results of the pilot program, SAGES will consider broad implementation of the new fellowship criteria.

  12. Essential oil composition of wild growing Sage from R. Macedonia

    Directory of Open Access Journals (Sweden)

    Gjoshe Stefkov

    2012-03-01

    Full Text Available The main objective of this study was to analyze and identify the essential oil composition of S. officinalis populations growing in Republic of Macedonia and to evaluate these data according to different standards’ requirements for, commercially most utilized, Dalmatian sage. The essential oil yield, obtained after hydrodestilation from leaves, of three different populations of Salvia officinalis L. from Republic of Macedonia was determined, varying from 1.40 to 3.46%. The GC/FID/MS analysis of the composition of the essential oils revealed 63, 57 and 51 components in Galicica Mtn., Jablanica Mtn. and Karaorman Mtn. sage populations, respectively. The main components of the oil, in all three samples, were the terpene hydrocarbons, encompassing the monoterpenes: camphor (13.15 - 25.91%, α-thujone (19.25 - 26.33%, β-thujone (2.03 - 5.28%, 1,8-cineole (6.51 – 13.60%, α-pinene (0.93 – 1.47%, borneol (1.07 – 4.67%, then sesquiterpenes: trans (E-caryophyllene (1.72 – 5.33%, α-humulene (2.89 – 7.99%, viridiflorol (4.27 – 7.99%, and the diterpene manool (2.13 - 3.79%. Thus, our results for the essential oil composition of sage complied with the reference values specified in the DAC 86 monograph for Salvia essential oil.

  13. The effect of sage, sodium erythorbate and a mixture of sage and sodium erythorbate on the quality of turkey meatballs stored under vacuum and modified atmosphere conditions.

    Science.gov (United States)

    Karpińska-Tymoszczyk, M

    2010-12-01

    1. The combined effect of sage (S), sodium erythorbate (SE), a mixture of sage and sodium erythorbate (MIX) and vacuum packaging (VP) and modified atmosphere packaging (MAP) on the quality of cooked turkey meatballs stored at 4°C was investigated. The physicochemical properties (colour, MDA, AV, pH, water activity), microbiological quality characteristics (counts of mesophilic and psychrotrophic bacteria, fungi, coliforms and Clostridium sp.) and flavour attributes of meatballs were determined. 2. The values of the colour parameters L*, a* and b* were affected by the additives and packaging method. The colour of meatballs was better protected by sodium erythorbate than by sage or a mixture of sage and sodium erythorbate. The additives effectively stabilised lipids against oxidation and slowed down hydrolytic changes in turkey meatballs. Sage and a mixture of sage and sodium erythorbate showed stronger antioxidant properties than sodium erythorbate added alone. Products with additives were characterised by better sensory quality than control samples. Sage and MIX prevented the growth of mesophilic and psychrotrophic bacteria. All additives inhibited the growth of coliforms. 3. MAP was more effective than VP in maintaining the microbial and sensory quality stability of cooked turkey meatballs. However, VP appears to be a better method as regards the maintaining of lipid stability in turkey meatballs.

  14. Using DNA from hairs left at depredated greater sage-grouse nests to detect mammalian nest predators

    Science.gov (United States)

    Christopher P. Kirol; Kristine L. Pilgrim; Andrew L. Sutphin; Thomas L. Maechtle

    2018-01-01

    Despite a multitude of studies on sage-grouse (Centrocercus spp.), there is still sparse information on the predator communities that influence sage-grouse productivity and how these predator communities may change when sagebrush habitats are altered by human activities. As a proof-of-concept, we used mammalian hairs collected at depredated greater sage-grouse (C....

  15. 77 FR 71396 - Humboldt-Toiyabe National Forest; Nevada and California Greater Sage Grouse Bi-State Distinct...

    Science.gov (United States)

    2012-11-30

    ... Greater Sage Grouse Bi-State Distinct Population Segment Forest Plan Amendment Environmental Impact... Sage Grouse Bi- State Distinct Population Segment. DATES: Comments concerning the scope of the analysis..., but precluded'' Endangered Species Act (ESA) listing petition decision for the Greater Sage grouse Bi...

  16. 78 FR 65703 - Notice of Availability of the Idaho and Southwestern Montana Greater Sage-Grouse Draft Land Use...

    Science.gov (United States)

    2013-11-01

    ...] Notice of Availability of the Idaho and Southwestern Montana Greater Sage-Grouse Draft Land Use Plan... Environmental Impact Statement (EIS) for managing Greater Sage- Grouse (GRSG) in the Idaho and Southwestern... Southwestern Montana Greater Sage-Grouse Draft LUP Amendments/Draft EIS by any of the following methods: Email...

  17. 78 FR 50088 - Notice of Availability of the Northwest Colorado Greater Sage-Grouse Draft Resource Management...

    Science.gov (United States)

    2013-08-16

    ... Availability of the Northwest Colorado Greater Sage- Grouse Draft Resource Management Plan Amendment and Draft... Land Management (BLM) has prepared a Northwest Colorado Greater Sage-Grouse Draft Resource Management.../or mailings. ADDRESSES: You may submit comments related to the Northwest Colorado Greater Sage-Grouse...

  18. 77 FR 12792 - Notice of Forest Service Land Management Plans To Be Amended To Incorporate Greater Sage-Grouse...

    Science.gov (United States)

    2012-03-02

    ... Forest Service Land Management Plans To Be Amended To Incorporate Greater Sage-Grouse Conservation... sage-grouse conservation measures into land use plans and land management plans. The BLM is the lead... submitted in writing until March 23, 2012. ADDRESSES: You may submit comments related to the greater sage...

  19. SAGE FOR MACINTOSH (MSAGE) VERSION 1.0 SOLVENT ALTERNATIVES GUIDE - USER'S GUIDE

    Science.gov (United States)

    The guide provides instructions for using the Solvent Alternatives Guide (SAGE) for Macintosh, version 1.0. The guide assumes that the user is familiar with the fundamentals of operating aMacintosh personal computer under the System 7.0 (or higher) operating system. SAGE for ...

  20. Sage-Grouse on the edge: understanding and managing western landscapes for their survival

    Science.gov (United States)

    Noreen Parks; Michael J. Wisdom

    2012-01-01

    Populations of greater sage-grouse have declined dramatically across their North American range for many decades in response to harmful effects of a plethora of human activities and land uses, prompting legal actions to protect the species under the Endangered Species Act (ESA). To evaluate the impacts of land-uses and habitat changes on sage-grouse, Michael Wisdom, a...

  1. Microhabitat selection of brood-rearing sites by greater sage-grouse in Carbon County, Wyoming

    Science.gov (United States)

    Leslie A. Schreiber; Christopher P. Hansen; Mark A. Rumble; Joshua J. Millspaugh; R. Scott Gamo; Jon W. Kehmeier; Nate Wojcik

    2015-01-01

    Declines in Greater Sage-Grouse (Centrocercus urophasianus, hereafter sage-grouse) populations could be attributed to low chick survival, which may be influenced by the availability of food and cover at sites used by females rearing broods. Habitat attributes important to broods may vary regionally; thus, it is necessary to understand factors affecting...

  2. Greater sage-grouse winter habitat use on the eastern edge of their range

    Science.gov (United States)

    Christopher C. Swanson; Mark A. Rumble; Nicholas W. Kaczor; Robert W. Klaver; Katie M. Herman-Brunson; Jonathan A. Jenks; Kent C. Jensen

    2013-01-01

    Greater sage-grouse (Centrocercus urophasianus) at the western edge of the Dakotas occur in the transition zone between sagebrush and grassland communities. These mixed sagebrush (Artemisia sp.) and grasslands differ from those habitats that comprise the central portions of the sage-grouse range; yet, no information is available on winter habitat selection within this...

  3. Stratospheric Aerosol and Gas Experiment III on the International Space Station (SAGE III/ISS)

    Science.gov (United States)

    Gasbarre, Joseph; Walker, Richard; Cisewski, Michael; Zawodny, Joseph; Cheek, Dianne; Thornton, Brooke

    2015-01-01

    The Stratospheric Aerosol and Gas Experiment III on the International Space Station (SAGE III/ISS) mission will extend the SAGE data record from the ideal vantage point of the International Space Station (ISS). The ISS orbital inclination is ideal for SAGE measurements providing coverage between 70 deg north and 70 deg south latitude. The SAGE data record includes an extensively validated data set including aerosol optical depth data dating to the Stratospheric Aerosol Measurement (SAM) experiments in 1975 and 1978 and stratospheric ozone profile data dating to the Stratospheric Aerosol and Gas Experiment (SAGE) in 1979. These and subsequent data records, notably from the SAGE II experiment launched on the Earth Radiation Budget Satellite in 1984 and the SAGE III experiment launched on the Russian Meteor-3M satellite in 2001, have supported a robust, long-term assessment of key atmospheric constituents. These scientific measurements provide the basis for the analysis of five of the nine critical constituents (aerosols, ozone (O3), nitrogen dioxide (NO2), water vapor (H2O), and air density using O2) identified in the U.S. National Plan for Stratospheric Monitoring. SAGE III on ISS was originally scheduled to fly on the ISS in the same timeframe as the Meteor-3M mission, but was postponed due to delays in ISS construction. The project was re-established in 2009.

  4. SAGE ANALYSIS OF TRANSCRIPTOME RESPONSES IN ARABIDOPSIS ROOTS EXPOSED TO 2,4,6-TRINITROTOLUENE

    Science.gov (United States)

    Serial Analysis of Gene Expression (SAGE) was used to profile transcript levels in Arabidopsis thaliana roots and assess their responses to 2,4,6-trinitrotoluene (TNT) exposure. SAGE libraries representing control and TNT-exposed seedling root transcripts were constructed, and ea...

  5. Greater sage-grouse apparent nest productivity and chick survival in Carbon County, Wyoming

    Science.gov (United States)

    Leslie A. Schreiber; Christopher P. Hansen; Mark A. Rumble; Joshua J. Millspaugh; Frank R. Thompson; R. Scott Gamo; Jon W. Kehmeier; Nate Wojik

    2016-01-01

    Greater sage-grouse Centrocercus urophasianus populations across North America have been declining due to degradation and fragmentation of sagebrush habitat. As part of a study quantifying greater sage-grouse demographics prior to construction of a wind energy facility, we estimated apparent net nest productivity and survival rate of chicks associated with...

  6. Evaluation of the similarity of gene expression data estimated with SAGE and Affymetrix GeneChips

    NARCIS (Netherlands)

    van Ruissen, Fred; Ruijter, Jan M.; Schaaf, Gerben J.; Asgharnegad, Lida; Zwijnenburg, Danny A.; Kool, Marcel; Baas, Frank

    2005-01-01

    Background: Serial Analysis of Gene Expression ( SAGE) and microarrays have found awidespread application, but much ambiguity exists regarding the evaluation of these technologies. Cross-platform utilization of gene expression data from the SAGE and microarray technology could reduce the need for

  7. Statistical comparison of two or more SAGE libraries: one tag at a time

    NARCIS (Netherlands)

    Schaaf, Gerben J.; van Ruissen, Fred; van Kampen, Antoine; Kool, Marcel; Ruijter, Jan M.

    2008-01-01

    Several statistical tests have been introduced for the comparison of serial analysis of gene expression (SAGE) libraries to quantitatively analyze the differential expression of genes. As each SAGE library is only one measurement, the necessary information on biological variation or experimental

  8. A Serial Analysis of Gene Expression (SAGE) database analysis of chemosensitivity

    DEFF Research Database (Denmark)

    Stein, Wilfred D; Litman, Thomas; Fojo, Tito

    2004-01-01

    are their corresponding solid tumors. We used the Serial Analysis of Gene Expression (SAGE) database to identify differences between solid tumors and cell lines, hoping to detect genes that could potentially explain differences in drug sensitivity. SAGE libraries were available for both solid tumors and cell lines from...

  9. Observations of territorial breeding common ravens caching eggs of greater sage-grouse

    Science.gov (United States)

    Howe, Kristy B.; Coates, Peter S.

    2015-01-01

    Previous investigations using continuous video monitoring of greater sage-grouse Centrocercus urophasianus nests have unambiguously identified common ravens Corvus corax as an important egg predator within the western United States. The quantity of greater sage-grouse eggs an individual common raven consumes during the nesting period and the extent to which common ravens actively hunt greater sage-grouse nests are largely unknown. However, some evidence suggests that territorial breeding common ravens, rather than nonbreeding transients, are most likely responsible for nest depredations. We describe greater sage-grouse egg depredation observations obtained opportunistically from three common raven nests located in Idaho and Nevada where depredated greater sage-grouse eggs were found at or in the immediate vicinity of the nest site, including the caching of eggs in nearby rock crevices. We opportunistically monitored these nests by counting and removing depredated eggs and shell fragments from the nest sites during each visit to determine the extent to which the common raven pairs preyed on greater sage-grouse eggs. To our knowledge, our observations represent the first evidence that breeding, territorial pairs of common ravens cache greater sage-grouse eggs and are capable of depredating multiple greater sage-grouse nests.

  10. The background of external γ radiation in the proportional counters in SAGE experiment

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Gorbachev, V.V.

    2003-01-01

    The influence of external γ radiation on the process of 71 Ge-decay counting in proportional counters in SAGE experiment of solar neutrino flux measurement is examined. One determines the systematic error of SAGE result, connected with radon decays inside the air volume surrounding the counters, and the background counting rate of proportional counters from γ radiation of passive and active shield [ru

  11. Greater sage-grouse nest predators in the Virginia Mountains of northwestern Nevada

    Science.gov (United States)

    Lockyer, Zachary B.; Coates, Peter S.; Casazza, Michael L.; Espinosa, Shawn; Delehanty, David J.

    2013-01-01

    Greater sage-grouse Centrocercus urophasianus, hereafter sage-grouse, populations have declined across their range due to the loss, degradation, and fragmentation of habitat. Habitat alterations can lead not only to vegetative changes but also to shifts in animal behavior and predator composition that may influence population vital rates, such as nest success. For example, common ravens Corvus corax are sage-grouse nest predators, and common raven abundance is positively associated with human-caused habitat alterations. Because nest success is a central component to sage-grouse population persistence, research that identifies factors influencing nest success will better inform conservation efforts. We used videography to unequivocally identify sage-grouse nest predators within the Virginia Mountains of northwestern Nevada, USA, from 2009 to 2011 and used maximum likelihood to calculate daily probability of nest survival. In the Virginia Mountains, fires, energy exploration, and other anthropogenic activities have altered historic sage-grouse habitat. We monitored 71 sage-grouse nests during the study, placing video cameras at 39 nests. Cumulative nest survival for all nests was 22.4% (95% CI, 13.0–33.4%), a survival rate that was significantly lower than other published results for sage-grouse in the Great Basin. Depredation was the primary cause for nest failure in our study (82.5%), and common ravens were the most frequent sage-grouse nest predator, accounting for 46.7% of nest depredations. We also successfully documented a suite of mammalian and reptilian species depredating sage-grouse nests, including some predators never previously confirmed in the literature to be sage-grouse nest predators (i.e., bobcats Lynx rufus and long-tailed weasels Mephitis frenata). Within the high elevation, disturbed habitat of the Virginia Mountains, low sage-grouse nest success may be limiting sage-grouse population growth. These results suggest that management actions that

  12. Biomedical Image Registration

    DEFF Research Database (Denmark)

    This book constitutes the refereed proceedings of the 8th International Workshop on Biomedical Image Registration, WBIR 2018, held in Leiden, The Netherlands, in June 2018. The 11 full and poster papers included in this volume were carefully reviewed and selected from 17 submitted papers. The pap...

  13. Locally orderless registration

    DEFF Research Database (Denmark)

    Darkner, Sune; Sporring, Jon

    2013-01-01

    This paper presents a unifying approach for calculating a wide range of popular, but seemingly very different, similarity measures. Our domain is the registration of n-dimensional images sampled on a regular grid, and our approach is well suited for gradient-based optimization algorithms. Our app...

  14. Registration of Plant Varieties

    African Journals Online (AJOL)

    Registration of two Sorghum Hybrids, ESH-1 and ESH-2. Sorghum (Sorghum bicolor (L) Moench) is an indigenous crop to Ethiopia and staple for many millions of people in most parts of Africa. The crop is one of the most important cereals grown in arid and semi arid areas where others often fail to survive. In Eastern Africa ...

  15. Headspace screening: A novel approach for fast quality assessment of the essential oil from culinary sage.

    Science.gov (United States)

    Cvetkovikj, Ivana; Stefkov, Gjoshe; Acevska, Jelena; Karapandzova, Marija; Dimitrovska, Aneta; Kulevanova, Svetlana

    2016-07-01

    Quality assessment of essential oil (EO) from culinary sage (Salvia officinalis L., Lamiaceae) is limited by the long pharmacopoeial procedure. The aim of this study was to employ headspace (HS) sampling in the quality assessment of sage EO. Different populations (30) of culinary sage were assessed using GC/FID/MS analysis of the hydrodistilled EO (pharmacopoeial method) and HS sampling directly from leaves. Compound profiles from both procedures were evaluated according to ISO 9909 and GDC standards for sage EO quality, revealing compliance for only 10 populations. Factors to convert HS values, for the target ISO and GDC components, into theoretical EO values were calculated. Statistical analysis revealed a significant relationship between HS and EO values for seven target components. Consequently, HS sampling could be used as a complementary extraction technique for rapid screening in quality assessment of sage EOs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  16. Conservation buffer distance estimates for Greater Sage-Grouse: a review

    Science.gov (United States)

    Manier, Daniel J.; Bowen, Zachary H.; Brooks, Matthew L.; Casazza, Michael L.; Coates, Peter S.; Deibert, Patricia A.; Hanser, Steven E.; Johnson, Douglas H.

    2014-01-01

    This report was prepared at the request of the U.S. Department of the Interior and is a compilation and summary of published scientific studies that evaluate the influence of anthropogenic activities and infrastructure on Greater Sage-Grouse(Centrocercus urophasianus; hereafter, sage-grouse) populations. The purpose of this report is to provide a convenient reference for land managers and others who are working to develop biologically relevant and socioeconomically practical buffer distances around sage-grouse habitats. The framework for this summary includes (1) addressing the potential effects of anthropogenic land use and disturbances on sage-grouse populations, (2) providing ecologically based interpretations of evidence from the scientific literature, and (3) informing implementation of conservation buffers around sage-grouse communal breeding locations—known as leks.

  17. Sparse Variational Bayesian SAGE Algorithm With Application to the Estimation of Multipath Wireless Channels

    DEFF Research Database (Denmark)

    Shutin, Dmitriy; Fleury, Bernard Henri

    2011-01-01

    In this paper, we develop a sparse variational Bayesian (VB) extension of the space-alternating generalized expectation-maximization (SAGE) algorithm for the high resolution estimation of the parameters of relevant multipath components in the response of frequency and spatially selective wireless...... channels. The application context of the algorithm considered in this contribution is parameter estimation from channel sounding measurements for radio channel modeling purpose. The new sparse VB-SAGE algorithm extends the classical SAGE algorithm in two respects: i) by monotonically minimizing...... parametric sparsity priors for the weights of the multipath components. We revisit the Gaussian sparsity priors within the sparse VB-SAGE framework and extend the results by considering Laplace priors. The structure of the VB-SAGE algorithm allows for an analytical stability analysis of the update expression...

  18. Effect of radiation processing on the antioxidant activity of Sage and Cinnamon

    International Nuclear Information System (INIS)

    El-Niley, H. F. G.; Farag, M. D. H.

    2012-12-01

    In the present study, the effect of radiation processing on dried sage leaves and cinnamon barks samples were carried out at dose level of 25 kGy. Total phenolic content was determined in the extracts of these herbs alongside the antioxidant properties of their methanoic extracts were assessed using reducing power assay and by DPPH radical test within an extract concentration range 2.5 to 40 mg/ml of methanol. The result showed the total phenolic compounds were increased by 11.18% and 10.19% for irradiated sage and cinnamon, respectively. The values of EC 50 estimated from the results of reducing power assay and DPPH radical test showed the sage extracts had higher antioxidant activity tham cinnamon extracts. In summary, gamma- irradiation of dried sage leaves and cinnamon barks was found to be significantly increase the antioxidant properties of dried sage leaves and cinnamon barks but also enhanced the antioxidant properties, to some extent. (Author)

  19. Mure skal holde zombierne ude

    DEFF Research Database (Denmark)

    Stockmarr, Leila

    2013-01-01

    Vi bygger som besatte mure og barrierer for at holde flygtninge ude og tæmme de negative konsekvenser af den neoliberale globalisering.......Vi bygger som besatte mure og barrierer for at holde flygtninge ude og tæmme de negative konsekvenser af den neoliberale globalisering....

  20. Thermal Modeling Method Improvements for SAGE III on ISS

    Science.gov (United States)

    Liles, Kaitlin; Amundsen, Ruth; Davis, Warren; McLeod, Shawn

    2015-01-01

    The Stratospheric Aerosol and Gas Experiment III (SAGE III) instrument is the fifth in a series of instruments developed for monitoring aerosols and gaseous constituents in the stratosphere and troposphere. SAGE III will be delivered to the International Space Station (ISS) via the SpaceX Dragon vehicle. A detailed thermal model of the SAGE III payload, which consists of multiple subsystems, has been developed in Thermal Desktop (TD). Many innovative analysis methods have been used in developing this model; these will be described in the paper. This paper builds on a paper presented at TFAWS 2013, which described some of the initial developments of efficient methods for SAGE III. The current paper describes additional improvements that have been made since that time. To expedite the correlation of the model to thermal vacuum (TVAC) testing, the chambers and GSE for both TVAC chambers at Langley used to test the payload were incorporated within the thermal model. This allowed the runs of TVAC predictions and correlations to be run within the flight model, thus eliminating the need for separate models for TVAC. In one TVAC test, radiant lamps were used which necessitated shooting rays from the lamps, and running in both solar and IR wavebands. A new Dragon model was incorporated which entailed a change in orientation; that change was made using an assembly, so that any potential additional new Dragon orbits could be added in the future without modification of the model. The Earth orbit parameters such as albedo and Earth infrared flux were incorporated as time-varying values that change over the course of the orbit; despite being required in one of the ISS documents, this had not been done before by any previous payload. All parameters such as initial temperature, heater voltage, and location of the payload are defined based on the case definition. For one component, testing was performed in both air and vacuum; incorporating the air convection in a submodel that was

  1. Clustering-based approaches to SAGE data mining

    Directory of Open Access Journals (Sweden)

    Wang Haiying

    2008-07-01

    Full Text Available Abstract Serial analysis of gene expression (SAGE is one of the most powerful tools for global gene expression profiling. It has led to several biological discoveries and biomedical applications, such as the prediction of new gene functions and the identification of biomarkers in human cancer research. Clustering techniques have become fundamental approaches in these applications. This paper reviews relevant clustering techniques specifically designed for this type of data. It places an emphasis on current limitations and opportunities in this area for supporting biologically-meaningful data mining and visualisation.

  2. Greater sage-grouse population trends across Wyoming

    Science.gov (United States)

    Edmunds, David; Aldridge, Cameron L.; O'Donnell, Michael; Monroe, Adrian

    2018-01-01

    The scale at which analyses are performed can have an effect on model results and often one scale does not accurately describe the ecological phenomena of interest (e.g., population trends) for wide-ranging species: yet, most ecological studies are performed at a single, arbitrary scale. To best determine local and regional trends for greater sage-grouse (Centrocercus urophasianus) in Wyoming, USA, we modeled density-independent and -dependent population growth across multiple spatial scales relevant to management and conservation (Core Areas [habitat encompassing approximately 83% of the sage-grouse population on ∼24% of surface area in Wyoming], local Working Groups [7 regional areas for which groups of local experts are tasked with implementing Wyoming's statewide sage-grouse conservation plan at the local level], Core Area status (Core Area vs. Non-Core Area) by Working Groups, and Core Areas by Working Groups). Our goal was to determine the influence of fine-scale population trends (Core Areas) on larger-scale populations (Working Group Areas). We modeled the natural log of change in population size ( peak M lek counts) by time to calculate the finite rate of population growth (λ) for each population of interest from 1993 to 2015. We found that in general when Core Area status (Core Area vs. Non-Core Area) was investigated by Working Group Area, the 2 populations trended similarly and agreed with the overall trend of the Working Group Area. However, at the finer scale where Core Areas were analyzed separately, Core Areas within the same Working Group Area often trended differently and a few large Core Areas could influence the overall Working Group Area trend and mask trends occurring in smaller Core Areas. Relatively close fine-scale populations of sage-grouse can trend differently, indicating that large-scale trends may not accurately depict what is occurring across the landscape (e.g., local effects of gas and oil fields may be masked by increasing

  3. The Chemotaxonomy of Common Sage (Salvia officinalis) Based on the Volatile Constituents.

    Science.gov (United States)

    Craft, Jonathan D; Satyal, Prabodh; Setzer, William N

    2017-06-29

    Background: Common sage ( Salvia officinalis ) is a popular culinary and medicinal herb. A literature survey has revealed that sage oils can vary widely in their chemical compositions. The purpose of this study was to examine sage essential oil from different sources/origins and to define the possible chemotypes of sage oil. Methods: Three different samples of sage leaf essential oil have been obtained and analyzed by GC-MS and GC-FID. A hierarchical cluster analysis was carried out on 185 sage oil compositions reported in the literature as well as the three samples in this study. Results: The major components of the three sage oils were the oxygenated monoterpenoids α-thujone (17.2-27.4%), 1,8-cineole (11.9-26.9%), and camphor (12.8-21.4%). The cluster analysis revealed five major chemotypes of sage oil, with the most common being a α-thujone > camphor > 1,8-cineole chemotype, of which the three samples in this study belong. The other chemotypes are an α-humulene-rich chemotype, a β-thujone-rich chemotype, a 1,8-cineole/camphor chemotype, and a sclareol/α-thujone chemotype. Conclusions: Most sage oils belonged to the "typical", α-thujone > camphor > 1,8-cineole, chemotype, but the essential oil compositions do vary widely and may have a profound effect on flavor and fragrance profiles as well as biological activities. There are currently no studies correlating sage oil composition with fragrance descriptions or with biological activities.

  4. The Stratospheric Aerosol and Gas Experiment (SAGE III) on the International Space Station (ISS) Mission

    Science.gov (United States)

    Cisewski, Michael; Zawodny, Joseph; Gasbarre, Joseph; Eckman, Richard; Topiwala, Nandkishore; Rodriquez-Alvarez, Otilia; Cheek, Dianne; Hall, Steve

    2014-01-01

    The Stratospheric Aerosol and Gas Experiment III on the International Space Station (SAGE III/ISS) mission will provide the science community with high-vertical resolution and nearly global observations of ozone, aerosols, water vapor, nitrogen dioxide, and other trace gas species in the stratosphere and upper-troposphere. SAGE III/ISS measurements will extend the long-term Stratospheric Aerosol Measurement (SAM) and SAGE data record begun in the 1970s. The multi-decadal SAGE ozone and aerosol data sets have undergone intense scrutiny and are considered the international standard for accuracy and stability. SAGE data have been used to monitor the effectiveness of the Montreal Protocol. Key objectives of the mission are to assess the state of the recovery in the distribution of ozone, to re-establish the aerosol measurements needed by both climate and ozone models, and to gain further insight into key processes contributing to ozone and aerosol variability. The space station mid-inclination orbit allows for a large range in latitude sampling and nearly continuous communications with payloads. The SAGE III instrument is the fifth in a series of instruments developed for monitoring atmospheric constituents with high vertical resolution. The SAGE III instrument is a moderate resolution spectrometer covering wavelengths from 290 nm to 1550 nm. Science data is collected in solar occultation mode, lunar occultation mode, and limb scatter measurement mode. A SpaceX Falcon 9 launch vehicle will provide access to space. Mounted in the unpressurized section of the Dragon trunk, SAGE III will be robotically removed from the Dragon and installed on the space station. SAGE III/ISS will be mounted to the ExPRESS Logistics Carrier-4 (ELC-4) location on the starboard side of the station. To facilitate a nadir view from this location, a Nadir Viewing Platform (NVP) payload was developed which mounts between the carrier and the SAGE III Instrument Payload (IP).

  5. The hidden KPI registration accuracy.

    Science.gov (United States)

    Shorrosh, Paul

    2011-09-01

    Determining the registration accuracy rate is fundamental to improving revenue cycle key performance indicators. A registration quality assurance (QA) process allows errors to be corrected before bills are sent and helps registrars learn from their mistakes. Tools are available to help patient access staff who perform registration QA manually.

  6. SAGE III on ISS Lessons Learned on Thermal Interface Design

    Science.gov (United States)

    Davis, Warren

    2015-01-01

    The Stratospheric Aerosol and Gas Experiment III (SAGE III) instrument - the fifth in a series of instruments developed for monitoring vertical distribution of aerosols, ozone, and other trace gases in the Earth's stratosphere and troposphere - is currently scheduled for delivery to the International Space Station (ISS) via the SpaceX Dragon vehicle in 2016. The Instrument Adapter Module (IAM), one of many SAGE III subsystems, continuously dissipates a considerable amount of thermal energy during mission operations. Although a portion of this energy is transferred via its large radiator surface area, the majority must be conductively transferred to the ExPRESS Payload Adapter (ExPA) to satisfy thermal mitigation requirements. The baseline IAM-ExPA mechanical interface did not afford the thermal conductance necessary to prevent the IAM from overheating in hot on-orbit cases, and high interfacial conductance was difficult to achieve given the large span between mechanical fasteners, less than stringent flatness specifications, and material usage constraints due to strict contamination requirements. This paper will examine the evolution of the IAM-ExPA thermal interface over the course of three design iterations and will include discussion on design challenges, material selection, testing successes and failures, and lessons learned.

  7. J.D.Bernal the sage of science

    CERN Document Server

    Brown, Andrew

    2005-01-01

    Desmond Bernal - or ''Sage'', as he was known, was an extraordinary man by any account - a brilliant scientist, a fervent Marxist, and a colourful, bohemian figure. This biography includes previously unpublished material from his diaries, and sheds new light on his international influence during both WWII and the ensuing peace movement. - ;J. D. Bernal, known as ''Sage'', was an extraordinary man and multifaceted character. A scientist of dazzling intellectual ability and a leading figure in the development of X-ray crystallography, he was a polymath, a fervent Marxist, and much admired worldwide. Although he himself never won a Nobel Prize, several of his distinguished students went on to do so, including Dorothy Hodgkin, Max Perutz, and Aaron Klug. Andrew Brown has had unprecedented access to Bernal''s papers and. diaries, and this biography includes previously unpublished material on Bernal''s role during the Second World War. Bernal not only changed the course of science, but was witness to (and often a p...

  8. SAGE CALCULATIONS OF THE TSUNAMI THREAT FROM LA PALMA

    Directory of Open Access Journals (Sweden)

    Galen Gisler

    2006-01-01

    Full Text Available With the LANL multiphysics hydrocode SAGE, we have performed several two-dimensional calculations and one three-dimensional calculation using the full Navier-Stokes equations, of a hypothetical landslide resembling the event posited by Ward and Day (2001, a lateral flank collapse of the Cumbre Vieja Volcano on La Palma that would produce a tsunami. The SAGE code has previously been used to model the Lituya Bay landslide-generated tsunami (Mader & Gittings, 2002, and has also been used to examine tsunami generation by asteroid impacts (Gisler, Weaver, Mader, & Gittings, 2003. This code uses continuous adaptive mesh refinement to focus computing resources where they are needed most, and accurate equations of state for water, air, and rock. We find that while high-amplitude waves are produced that would be highly dangerous to nearby communities (in the Canary Islands, and the shores of Morocco, Spain, and Portugal, the wavelengths and periods of these waves are relatively short, and they will not propagate efficiently over long distances.

  9. Registration of acute stroke

    DEFF Research Database (Denmark)

    Wildenschild, Cathrine; Mehnert, Frank; Thomsen, Reimar Wernich

    2014-01-01

    BACKGROUND: The validity of the registration of patients in stroke-specific registries has seldom been investigated, nor compared with administrative hospital discharge registries. The objective of this study was to examine the validity of the registration of patients in a stroke-specific registry...... (The Danish Stroke Registry [DSR]) and a hospital discharge registry (The Danish National Patient Registry [DNRP]). METHODS: Assuming that all patients with stroke were registered in either the DSR, DNRP or both, we first identified a sample of 75 patients registered with stroke in 2009; 25 patients...... in the DSR, 25 patients in the DNRP, and 25 patients registered in both data sources. Using the medical record as a gold standard, we then estimated the sensitivity and positive predictive value of a stroke diagnosis in the DSR and the DNRP. Secondly, we reviewed 160 medical records for all potential stroke...

  10. Image registration with uncertainty analysis

    Science.gov (United States)

    Simonson, Katherine M [Cedar Crest, NM

    2011-03-22

    In an image registration method, edges are detected in a first image and a second image. A percentage of edge pixels in a subset of the second image that are also edges in the first image shifted by a translation is calculated. A best registration point is calculated based on a maximum percentage of edges matched. In a predefined search region, all registration points other than the best registration point are identified that are not significantly worse than the best registration point according to a predetermined statistical criterion.

  11. Serial analysis of gene expression (SAGE) in normal human trabecular meshwork.

    Science.gov (United States)

    Liu, Yutao; Munro, Drew; Layfield, David; Dellinger, Andrew; Walter, Jeffrey; Peterson, Katherine; Rickman, Catherine Bowes; Allingham, R Rand; Hauser, Michael A

    2011-04-08

    To identify the genes expressed in normal human trabecular meshwork tissue, a tissue critical to the pathogenesis of glaucoma. Total RNA was extracted from human trabecular meshwork (HTM) harvested from 3 different donors. Extracted RNA was used to synthesize individual SAGE (serial analysis of gene expression) libraries using the I-SAGE Long kit from Invitrogen. Libraries were analyzed using SAGE 2000 software to extract the 17 base pair sequence tags. The extracted sequence tags were mapped to the genome using SAGE Genie map. A total of 298,834 SAGE tags were identified from all HTM libraries (96,842, 88,126, and 113,866 tags, respectively). Collectively, there were 107,325 unique tags. There were 10,329 unique tags with a minimum of 2 counts from a single library. These tags were mapped to known unique Unigene clusters. Approximately 29% of the tags (orphan tags) did not map to a known Unigene cluster. Thirteen percent of the tags mapped to at least 2 Unigene clusters. Sequence tags from many glaucoma-related genes, including myocilin, optineurin, and WD repeat domain 36, were identified. This is the first time SAGE analysis has been used to characterize the gene expression profile in normal HTM. SAGE analysis provides an unbiased sampling of gene expression of the target tissue. These data will provide new and valuable information to improve understanding of the biology of human aqueous outflow.

  12. Gene expression profiling of human breast tissue samples using SAGE-Seq.

    Science.gov (United States)

    Wu, Zhenhua Jeremy; Meyer, Clifford A; Choudhury, Sibgat; Shipitsin, Michail; Maruyama, Reo; Bessarabova, Marina; Nikolskaya, Tatiana; Sukumar, Saraswati; Schwartzman, Armin; Liu, Jun S; Polyak, Kornelia; Liu, X Shirley

    2010-12-01

    We present a powerful application of ultra high-throughput sequencing, SAGE-Seq, for the accurate quantification of normal and neoplastic mammary epithelial cell transcriptomes. We develop data analysis pipelines that allow the mapping of sense and antisense strands of mitochondrial and RefSeq genes, the normalization between libraries, and the identification of differentially expressed genes. We find that the diversity of cancer transcriptomes is significantly higher than that of normal cells. Our analysis indicates that transcript discovery plateaus at 10 million reads/sample, and suggests a minimum desired sequencing depth around five million reads. Comparison of SAGE-Seq and traditional SAGE on normal and cancerous breast tissues reveals higher sensitivity of SAGE-Seq to detect less-abundant genes, including those encoding for known breast cancer-related transcription factors and G protein-coupled receptors (GPCRs). SAGE-Seq is able to identify genes and pathways abnormally activated in breast cancer that traditional SAGE failed to call. SAGE-Seq is a powerful method for the identification of biomarkers and therapeutic targets in human disease.

  13. Preliminary assessment of possible aerosol contamination effects on SAGE ozone trends in the lower stratosphere

    Science.gov (United States)

    Cunnold, Derek M.; Veiga, Robert E.

    1991-01-01

    An investigation of the validity of long-term ozone trends in the lower stratosphere derived from SAGE I and II measurements is described. At altitudes below approximately 20 km, it is important to separate the ozone and aerosol contributions to SAGE extinction at 600 nm. The correlation between SAGE II measurements of ozone and aerosols indicates that most of the variability in these parameters is associated with physically induced variations resulting from quasi-horizontal motions of air parcels. The SAGE ozone measurements are however found to be as much as 20 percent larger than coincident ozonesonde measurements between 15 and 20 km altitude. A sudden change in the difference at approximately 14.5 km altitude for which there is a change in the SAGE aerosol retrieval procedure suggests that SAGE ozone trends below 20 km altitude may be more sensitive to aerosol variations. Between 20 and 25 km altitude, however, both SAGE and the ozonesondes indicate a reduction in ozone of approximately 0.5 percent/year over the period 1979 to 1989 at midlatitudes of the Northern Hemisphere.

  14. Preliminary analysis of Greater Sage-grouse reproduction in the Virginia Mountains of northwestern Nevada

    Science.gov (United States)

    Coates, Peter S.; Lockyer, Zachary B.; Farinha, Melissa A.; Sweeney, Joelle M.; Johnson, Valerie M.; Meshriy, Matthew G.; Espinosa, Shawn P.; Delehanty, David J.; Casazza, Michael L.

    2011-01-01

    Relationships between habitat selection and population vital rates of greater sage-grouse (Centrocercus urophasianus; hereafter sage-grouse), recently designated as a candidate species under the Endangered Species Act, within the Great Basin are not well-understood. The growing development of renewable energy infrastructure within areas inhabited by sage-grouse is thought to influence predator and vegetation communities. For example, common ravens (Corvus corax), a synanthropic sage-grouse nest predator, are increasing range-wide and select transmission lines and other tall structures for nesting and perching. In the Virginia Mountains of northwestern Nevada, we collected preliminary information of space-use, habitat selection, and population vital rates during the nesting and brood-rearing period over two years on 56 sage-grouse. Additionally, videography at nest sites (n = 22) was used to identify sage-grouse nest predators. The study area is a potential site for renewable energy developments (i.e., wind and solar), and we plan to continue monitoring this population using a before-after-control-impact study design. The results reported here are preliminary and further data are required before conclusions can be drawn from this population of sage-grouse.

  15. Conservation of greater sage-grouse- a synthesis of current trends and future management

    Science.gov (United States)

    Connelly, John W.; Knick, Steven T.; Braun, Clait E.; Baker, William L.; Beever, Erik A.; Christiansen, Thomas J.; Doherty, Kevin E.; Garton, Edward O.; Hagen, Christian A.; Hanser, Steven E.; Johnson, Douglas H.; Leu, Matthias; Miller, Richard F.; Naugle, David E.; Oyler-McCance, Sara J.; Pyke, David A.; Reese, Kerry P.; Schroeder, Michael A.; Stiver, San J.; Walker, Brett L.; Wisdorn, Michael J.

    2011-01-01

    Recent analyses of Greater Sage-Grouse (Centrocercus urophasianus) populations indicate substantial declines in many areas but relatively stable populations in other portions of the species? range. Sagebrush (Artemisia spp.) habitats neces-sary to support sage-grouse are being burned by large wildfires, invaded by nonnative plants, and developed for energy resources (gas, oil, and wind). Management on public lands, which con-tain 70% of sagebrush habitats, has changed over the last 30 years from large sagebrush control projects directed at enhancing livestock grazing to a greater emphasis on projects that often attempt to improve or restore ecological integrity. Never-theless, the mandate to manage public lands to provide traditional consumptive uses as well as recreation and wilderness values is not likely to change in the near future. Consequently, demand and use of resources contained in sagebrush land-scapes plus the associated infrastructure to sup-port increasing human populations in the western United States will continue to challenge efforts to conserve Greater Sage-Grouse. The continued widespread distribution of sage-grouse, albeit at very low densities in some areas, coupled with large areas of important sagebrush habitat that are relatively unaffected by the human footprint, sug-gest that Greater Sage-Grouse populations may be able to persist into the future. We summarize the status of sage-grouse populations and habitats, provide a synthesis of major threats and chal-lenges to conservation of sage-grouse, and suggest a roadmap to attaining conservation goals.

  16. Blue breath holding is benign.

    OpenAIRE

    Stephenson, J B

    1991-01-01

    In their recent publication in this journal, Southall et al described typical cyanotic breath holding spells, both in otherwise healthy children and in those with brainstem lesions and other malformations. Their suggestions regarding possible autonomic disturbances may require further study, but they have adduced no scientific evidence to contradict the accepted view that in the intact child blue breath holding spells are benign. Those families in which an infant suffers an 'apparently life t...

  17. Defining the Human Macula Transcriptome and Candidate Retinal Disease Genes UsingEyeSAGE

    Science.gov (United States)

    Rickman, Catherine Bowes; Ebright, Jessica N.; Zavodni, Zachary J.; Yu, Ling; Wang, Tianyuan; Daiger, Stephen P.; Wistow, Graeme; Boon, Kathy; Hauser, Michael A.

    2009-01-01

    Purpose To develop large-scale, high-throughput annotation of the human macula transcriptome and to identify and prioritize candidate genes for inherited retinal dystrophies, based on ocular-expression profiles using serial analysis of gene expression (SAGE). Methods Two human retina and two retinal pigment epithelium (RPE)/choroid SAGE libraries made from matched macula or midperipheral retina and adjacent RPE/choroid of morphologically normal 28- to 66-year-old donors and a human central retina longSAGE library made from 41- to 66-year-old donors were generated. Their transcription profiles were entered into a relational database, EyeSAGE, including microarray expression profiles of retina and publicly available normal human tissue SAGE libraries. EyeSAGE was used to identify retina- and RPE-specific and -associated genes, and candidate genes for retina and RPE disease loci. Differential and/or cell-type specific expression was validated by quantitative and single-cell RT-PCR. Results Cone photoreceptor-associated gene expression was elevated in the macula transcription profiles. Analysis of the longSAGE retina tags enhanced tag-to-gene mapping and revealed alternatively spliced genes. Analysis of candidate gene expression tables for the identified Bardet-Biedl syndrome disease gene (BBS5) in the BBS5 disease region table yielded BBS5 as the top candidate. Compelling candidates for inherited retina diseases were identified. Conclusions The EyeSAGE database, combining three different gene-profiling platforms including the authors’ multidonor-derived retina/RPE SAGE libraries and existing single-donor retina/RPE libraries, is a powerful resource for definition of the retina and RPE transcriptomes. It can be used to identify retina-specific genes, including alternatively spliced transcripts and to prioritize candidate genes within mapped retinal disease regions. PMID:16723438

  18. Ecology of sage grouse on the Idaho National Engineering Laboratory Site

    International Nuclear Information System (INIS)

    Connelly, J.W.; Ball, I.J.

    1978-01-01

    A comprehensive study of the sage grouse ecology was initiated on the INEL Site in 1977. Objectives include documentation of radionuclide concentrations, population size, habitat use, and movement patterns of sage grouse on the Site. Sixteen grouse have been collected and radionuclide concentrations determined. Only part of the Site and surrounding area have been adequately searched for strutting grounds (leks), but 32 have been located to date. Trapping success has been strongly influenced by weather conditions and by the season; 121 sage grouse have been captured, banded, and color- and radio-marked

  19. Summer Camp Registrations 2018

    CERN Multimedia

    Staff Association

    2018-01-01

    Registration for the CERN SA Summer camp, for children from 4 to 6 years old, is now open. The general conditions are available on the EVE and School website: http://nurseryschool.web.cern.ch For further questions, please contact us by email at  Summer.Camp@cern.ch An inscription per week is proposed, for 450.-CHF/week, lunch included. The camp will be open on weeks 27, 28, 29 and 30, from 8:30 am to 5:30 pm. This year the theme will be Vivaldi’s Four Seasons.

  20. The Household Registration System

    Directory of Open Access Journals (Sweden)

    2000-06-01

    Full Text Available Although longitudinal experimental community health research is crucial to testing hypotheses about the demographic impact of health technologies, longitudinal demographic research field stations are rare, owing to the complexity and high cost of developing requisite computer software systems. This paper describes the Household Registration System (HRS, a software package that has been used for the rapid development of eleven surveillance systems in sub-Saharan Africa and Asia. Features of the HRS automate software generation for a family of surveillance applications, obviating the need for new and complex computer software systems for each new longitudinal demographic study.

  1. Registration Summer Camp 2016

    CERN Multimedia

    2016-01-01

    Reminder: registration for the CERN Staff Association Summer Camp is now open for children from 4 to 6 years old.   More information on the website: http://nurseryschool.web.cern.ch/. The summer camp is open to all children. The proposed cost is 480.-CHF/week, lunch included. The camp will be open weeks 27, 28, 29 and 30, from 8:30 a.m. to 5:30 p.m. For further questions, you are welcome to contact us by email at Summer.Camp@cern.ch. CERN Staff Association

  2. Solar neutrino and 51Cr results from SAGE

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Abdurashitov, J.N.; Girin, S.V.

    1997-01-01

    The Russian-American solar neutrino Experiment (SAGE) has carried out measurements of the capture rate of solar neutrinos on metallic gallium in a radiochemical experiment at the Baksan Neutrino Observatory during the period January 1990 to December 1994. The measured capture rate on 71 Ga is 72+12/-10 (stat) +5/-7 (syst) SNU. This represents only 53-59 % of the predicted Standard Solar Model (SSM) rates. Taken together with the measurements of the other solar neutrino experiments, this deficit would appear to be best interpreted as due to Mikheyev-Smirnov-Wolfenstein neutrino oscillations. A measurement of the production rate of 71 Ge by an intense 51 Cr source to test the overall operation of the experiment showed the extraction efficiency was 0.95 ± 0.11 (stat) +0.05/-0.08 (syst), indicating that the experiment is operating as expected. (orig.)

  3. Identifying novel genes in C. elegans using SAGE tags

    Directory of Open Access Journals (Sweden)

    Chen Nansheng

    2010-12-01

    Full Text Available Abstract Background Despite extensive efforts devoted to predicting protein-coding genes in genome sequences, many bona fide genes have not been found and many existing gene models are not accurate in all sequenced eukaryote genomes. This situation is partly explained by the fact that gene prediction programs have been developed based on our incomplete understanding of gene feature information such as splicing and promoter characteristics. Additionally, full-length cDNAs of many genes and their isoforms are hard to obtain due to their low level or rare expression. In order to obtain full-length sequences of all protein-coding genes, alternative approaches are required. Results In this project, we have developed a method of reconstructing full-length cDNA sequences based on short expressed sequence tags which is called sequence tag-based amplification of cDNA ends (STACE. Expressed tags are used as anchors for retrieving full-length transcripts in two rounds of PCR amplification. We have demonstrated the application of STACE in reconstructing full-length cDNA sequences using expressed tags mined in an array of serial analysis of gene expression (SAGE of C. elegans cDNA libraries. We have successfully applied STACE to recover sequence information for 12 genes, for two of which we found isoforms. STACE was used to successfully recover full-length cDNA sequences for seven of these genes. Conclusions The STACE method can be used to effectively reconstruct full-length cDNA sequences of genes that are under-represented in cDNA sequencing projects and have been missed by existing gene prediction methods, but their existence has been suggested by short sequence tags such as SAGE tags.

  4. IMPACT OF COSOLVENT FLUSHING ON SUBSURFACE MICROBIAL ECOLOGY AT THE FORMER SAGE'S DRY CLEANER SITE

    Science.gov (United States)

    The Solvent Extraction Residual Biotreatment (SERB) technology was evaluated at the former Sage's Dry Cleaner site in Jacksonville, FL where an area of tetrachloroethylene (PCE) contamination was identified. The SERB technology is a treatment train approach to complete site rest...

  5. Maximum likelihood reconstruction in fully 3D PET via the SAGE algorithm

    International Nuclear Information System (INIS)

    Ollinger, J.M.; Goggin, A.S.

    1996-01-01

    The SAGE and ordered subsets algorithms have been proposed as fast methods to compute penalized maximum likelihood estimates in PET. We have implemented both for use in fully 3D PET and completed a preliminary evaluation. The technique used to compute the transition matrix is fully described. The evaluation suggests that the ordered subsets algorithm converges much faster than SAGE, but that it stops short of the optimal solution

  6. Importance of regional variation in conservation planning: A rangewide example of the Greater Sage-Grouse

    Science.gov (United States)

    Doherty, Kevin E.; Evans, Jeffrey S.; Coates, Peter S.; Juliusson, Lara; Fedy, Bradley C.

    2016-01-01

    We developed rangewide population and habitat models for Greater Sage-Grouse (Centrocercus urophasianus) that account for regional variation in habitat selection and relative densities of birds for use in conservation planning and risk assessments. We developed a probabilistic model of occupied breeding habitat by statistically linking habitat characteristics within 4 miles of an occupied lek using a nonlinear machine learning technique (Random Forests). Habitat characteristics used were quantified in GIS and represent standard abiotic and biotic variables related to sage-grouse biology. Statistical model fit was high (mean correctly classified = 82.0%, range = 75.4–88.0%) as were cross-validation statistics (mean = 80.9%, range = 75.1–85.8%). We also developed a spatially explicit model to quantify the relative density of breeding birds across each Greater Sage-Grouse management zone. The models demonstrate distinct clustering of relative abundance of sage-grouse populations across all management zones. On average, approximately half of the breeding population is predicted to be within 10% of the occupied range. We also found that 80% of sage-grouse populations were contained in 25–34% of the occupied range within each management zone. Our rangewide population and habitat models account for regional variation in habitat selection and the relative densities of birds, and thus, they can serve as a consistent and common currency to assess how sage-grouse habitat and populations overlap with conservation actions or threats over the entire sage-grouse range. We also quantified differences in functional habitat responses and disturbance thresholds across the Western Association of Fish and Wildlife Agencies (WAFWA) management zones using statistical relationships identified during habitat modeling. Even for a species as specialized as Greater Sage-Grouse, our results show that ecological context matters in both the strength of habitat selection (i

  7. U.S. Geological Survey sage-grouse and sagebrush ecosystem research annual report for 2017

    Science.gov (United States)

    Hanser, Steven E.

    2017-09-08

    The sagebrush (Artemisia spp.) ecosystem extends across a large portion of the Western United States, and the greater sage-grouse (Centrocercus urophasianus) is one of the iconic species of this ecosystem. Greater sage-grouse populations occur in 11 States and are dependent on relatively large expanses of sagebrush-dominated habitat. Sage-grouse populations have been experiencing long-term declines owing to multiple stressors, including interactions among fire, exotic plant invasions, and human land uses, which have resulted in significant loss, fragmentation, and degradation of landscapes once dominated by sagebrush. In addition to the sage-grouse, over 350 species of plants and animals are dependent on the sagebrush ecosystem.Increasing knowledge about how these species and the sagebrush ecosystem respond to these stressors and to management actions can inform and improve strategies to maintain existing areas of intact sagebrush and restore degraded landscapes. The U.S. Geological Survey (USGS) has a broad research program focused on providing the science needed to inform these strate-gies and to help land and resource managers at the Federal, State, Tribal, and local levels as they work towards sustainable sage-grouse populations and restored landscapes for the broad range of uses critical to stakeholders in the Western United States.USGS science has provided a foundation for major land and resource management decisions including those that precluded the need to list the greater sage-grouse under the Endangered Species Act. The USGS is continuing to build on that foundation to inform science-based decisions to help support local economies and the continued conservation, management, and restoration of the sagebrush ecosystem.This report contains descriptions of USGS sage-grouse and sagebrush ecosystem research projects that are ongoing or were active during 2017 and is organized into five thematic areas: Fire, Invasive Species, Restoration, Sagebrush and Sage

  8. Does Wyoming's Core Area Policy Protect Winter Habitats for Greater Sage-Grouse?

    Science.gov (United States)

    Smith, Kurt T.; Beck, Jeffrey L.; Pratt, Aaron C.

    2016-10-01

    Conservation reserves established to protect important habitat for wildlife species are used world-wide as a wildlife conservation measure. Effective reserves must adequately protect year-round habitats to maintain wildlife populations. Wyoming's Sage-Grouse Core Area policy was established to protect breeding habitats for greater sage-grouse ( Centrocercus urophasianus). Protecting only one important seasonal habitat could result in loss or degradation of other important habitats and potential declines in local populations. The purpose of our study was to identify the timing of winter habitat use, the extent which individuals breeding in Core Areas used winter habitats, and develop resource selection functions to assess effectiveness of Core Areas in conserving sage-grouse winter habitats in portions of 5 Core Areas in central and north-central Wyoming during winters 2011-2015. We found that use of winter habitats occured over a longer period than current Core Area winter timing stipulations and a substantial amount of winter habitat outside of Core Areas was used by individuals that bred in Core Areas, particularly in smaller Core Areas. Resource selection functions for each study area indicated that sage-grouse were selecting habitats in response to landscapes dominated by big sagebrush and flatter topography similar to other research on sage-grouse winter habitat selection. The substantial portion of sage-grouse locations and predicted probability of selection during winter outside small Core Areas illustrate that winter requirements for sage-grouse are not adequately met by existing Core Areas. Consequently, further considerations for identifying and managing important winter sage-grouse habitats under Wyoming's Core Area Policy are warranted.

  9. Background of external γ radiation in the proportional counters of the SAGE experiment

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Gorbachev, V.V.

    2003-01-01

    The effect of external γ radiation on the process of counting 71 Ge decays in the proportional counters of the SAGE experiment measuring the solar-neutrino flux is considered. The systematic uncertainty in the SAGE result due to radon decays inside the air volume surrounding the counters is estimated. The background counting rate in the proportional counters that is caused by γ radiation from the enclosing shield is also determined

  10. Sustainability via Active Garden Education (SAGE): results from two feasibility pilot studies.

    Science.gov (United States)

    Lee, Rebecca E; Parker, Nathan H; Soltero, Erica G; Ledoux, Tracey A; Mama, Scherezade K; McNeill, Lorna

    2017-03-10

    Low physical activity (PA) and fruit and vegetable (F&V) consumption in early childhood are continued public health challenges. This manuscript describes outcomes from two pilot studies for Sustainability via Active Garden Education (SAGE), a program designed to increase PA and F&V consumption among 3 to 5 year old children. SAGE was developed using community-based participatory research (CBPR) and delivered to children (N = 89) in early care and education centers (ECEC, N = 6) in two US cities. Children participated in 12 one-hour sessions that included songs, games, and interactive learning activities involving garden maintenance and taste tests. We evaluated reach, efficacy, adoption, implementation, and potential for maintenance of SAGE following the RE-AIM framework. Reach was evaluated by comparing demographic characteristics among SAGE participants and residents of target geographic areas. Efficacy was evaluated with accelerometer-measured PA, F&V consumption, and eating in the absence of hunger among children, parenting practices regarding PA, and home availability of F&V. Adoption was evaluated by the number of ECEC that participated relative to the number of ECEC that were recruited. Implementation was evaluated by completion rates of planned SAGE lessons and activities, and potential for maintenance was evaluated with a parent satisfaction survey. SAGE reached ECEC in neighborhoods representing a wide range of socioeconomic status, with participants' sociodemographic characteristics representing those of the intervention areas. Children significantly increased PA during SAGE lessons compared to usual lessons, but they also consumed more calories in the absence of hunger in post- vs. pre-intervention tests (both p nutrition guidelines for young children. SAGE successfully translated national PA guidelines to practice for young children but was less successful with nutrition guidelines. High adoption and implementation and favorable parent

  11. Connections between Transcription Downstream of Genes and cis-SAGe Chimeric RNA.

    Science.gov (United States)

    Chwalenia, Katarzyna; Qin, Fujun; Singh, Sandeep; Tangtrongstittikul, Panjapon; Li, Hui

    2017-11-22

    cis-Splicing between adjacent genes (cis-SAGe) is being recognized as one way to produce chimeric fusion RNAs. However, its detail mechanism is not clear. Recent study revealed induction of transcriptions downstream of genes (DoGs) under osmotic stress. Here, we investigated the influence of osmotic stress on cis-SAGe chimeric RNAs and their connection to DoGs. We found,the absence of induction of at least some cis-SAGe fusions and/or their corresponding DoGs at early time point(s). In fact, these DoGs and their cis-SAGe fusions are inversely correlated. This negative correlation was changed to positive at a later time point. These results suggest a direct competition between the two categories of transcripts when total pool of readthrough transcripts is limited at an early time point. At a later time point, DoGs and corresponding cis-SAGe fusions are both induced, indicating that total readthrough transcripts become more abundant. Finally, we observed overall enhancement of cis-SAGe chimeric RNAs in KCl-treated samples by RNA-Seq analysis.

  12. Data resource profile: the World Health Organization Study on global AGEing and adult health (SAGE).

    Science.gov (United States)

    Kowal, Paul; Chatterji, Somnath; Naidoo, Nirmala; Biritwum, Richard; Fan, Wu; Lopez Ridaura, Ruy; Maximova, Tamara; Arokiasamy, Perianayagam; Phaswana-Mafuya, Nancy; Williams, Sharon; Snodgrass, J Josh; Minicuci, Nadia; D'Este, Catherine; Peltzer, Karl; Boerma, J Ties

    2012-12-01

    Population ageing is rapidly becoming a global issue and will have a major impact on health policies and programmes. The World Health Organization's Study on global AGEing and adult health (SAGE) aims to address the gap in reliable data and scientific knowledge on ageing and health in low- and middle-income countries. SAGE is a longitudinal study with nationally representative samples of persons aged 50+ years in China, Ghana, India, Mexico, Russia and South Africa, with a smaller sample of adults aged 18-49 years in each country for comparisons. Instruments are compatible with other large high-income country longitudinal ageing studies. Wave 1 was conducted during 2007-2010 and included a total of 34 124 respondents aged 50+ and 8340 aged 18-49. In four countries, a subsample consisting of 8160 respondents participated in Wave 1 and the 2002/04 World Health Survey (referred to as SAGE Wave 0). Wave 2 data collection will start in 2012/13, following up all Wave 1 respondents. Wave 3 is planned for 2014/15. SAGE is committed to the public release of study instruments, protocols and meta- and micro-data: access is provided upon completion of a Users Agreement available through WHO's SAGE website (www.who.int/healthinfo/systems/sage) and WHO's archive using the National Data Archive application (http://apps.who.int/healthinfo/systems/surveydata).

  13. Generation of Chimeric RNAs by cis-splicing of adjacent genes (cis-SAGe) in mammals.

    Science.gov (United States)

    Zhuo, Jian-Shu; Jing, Xiao-Yan; Du, Xin; Yang, Xiu-Qin

    2018-02-20

    Chimeric RNA molecules, possessing exons from two or more independent genes, are traditionally believed to be produced by chromosome rearrangement. However, recent studies revealed that cis-splicing of adjacent genes (cis- SAGe) is one of the major mechanisms underlying the formation of chimeric RNAs. cis-SAGe refers to intergenic splicing of directly adjacent genes with the same transcriptional orientation, resulting in read-through transcripts, termed chimeric RNAs, which contain sequences from two or more parental genes. cis-SAGe was first identified in tumor cells, since then its potential in carcinogenesis has attracted extensive attention. More and more scientists are focusing on it. With the development of research, cis-SAGe was found to be ubiquitous in various normal tissues, and might make a crucial contribution to the formation of novel genes in the evolution of genomes. In this review, we summarize the splicing pattern, expression characteristics, possible mechanisms, and significance of cis-SAGe in mammals. This review will be helpful for general understanding of the current status and development tendency of cis-SAGe.

  14. The Holding Power of Anchors

    Indian Academy of Sciences (India)

    The efficiency of an anchor may be expressed as the ratio (holding force + weight of anchor). In dry sand .... the market at the beginning of the coming season in three sizes, namely 20, 35 and. 60 lb. These are ... Taylor frozen-flow hypothesis.

  15. The Capability to Hold Property

    NARCIS (Netherlands)

    Claassen, Rutger

    2015-01-01

    This paper discusses the question of whether a capability theory of justice (such as that of Martha Nussbaum) should accept a basic “capability to hold property.” Answering this question is vital for bridging the gap between abstract capability theories of justice and their institutional

  16. 32 CFR 1615.1 - Registration.

    Science.gov (United States)

    2010-07-01

    ... registration card or other method of registration prescribed by the Director of Selective Service by a person... the records (master computer file) of the Selective Service System. Registration is completed when... Director include completing a Selective Service Registration Card at a classified Post Office, registration...

  17. Sustainability via Active Garden Education (SAGE: results from two feasibility pilot studies

    Directory of Open Access Journals (Sweden)

    Rebecca E. Lee

    2017-03-01

    Full Text Available Abstract Background Low physical activity (PA and fruit and vegetable (F&V consumption in early childhood are continued public health challenges. This manuscript describes outcomes from two pilot studies for Sustainability via Active Garden Education (SAGE, a program designed to increase PA and F&V consumption among 3 to 5 year old children. Methods SAGE was developed using community-based participatory research (CBPR and delivered to children (N = 89 in early care and education centers (ECEC, N = 6 in two US cities. Children participated in 12 one-hour sessions that included songs, games, and interactive learning activities involving garden maintenance and taste tests. We evaluated reach, efficacy, adoption, implementation, and potential for maintenance of SAGE following the RE-AIM framework. Reach was evaluated by comparing demographic characteristics among SAGE participants and residents of target geographic areas. Efficacy was evaluated with accelerometer-measured PA, F&V consumption, and eating in the absence of hunger among children, parenting practices regarding PA, and home availability of F&V. Adoption was evaluated by the number of ECEC that participated relative to the number of ECEC that were recruited. Implementation was evaluated by completion rates of planned SAGE lessons and activities, and potential for maintenance was evaluated with a parent satisfaction survey. Results SAGE reached ECEC in neighborhoods representing a wide range of socioeconomic status, with participants’ sociodemographic characteristics representing those of the intervention areas. Children significantly increased PA during SAGE lessons compared to usual lessons, but they also consumed more calories in the absence of hunger in post- vs. pre-intervention tests (both p < .05. Parent reports did not suggest changes in F&V consumption, parenting PA practices, or home F&V availability, possibly due to low parent engagement. ECEC had moderate

  18. Spatial heterogeneity in response of male greater sage-grouse lek attendance to energy development.

    Directory of Open Access Journals (Sweden)

    Andrew J Gregory

    Full Text Available Landscape modification due to rapidly expanding energy development, in particular oil and gas, in the westernUSA, have prompted concerns over how such developments may impact wildlife. One species of conservation concern across much of the Intermountain West is the greater sage-grouse (Centrocercusurophasianus. Sage-grouse have been petitioned for listing under provisions of the Endangered Species Act 7 times and the state of Wyoming alone represents 64% of the extant sage-grouse population in the eastern portion of their range. Consequently, the relationship between sage-grouse populations and oil and gas development in Wyoming is an important component to managing the long-term viability of this species. We used 814 leks from the Wyoming Game and Fish Department's lek survey database and well pad data from the Wyoming Oil and Gas Conservation Commission to evaluate changes in sage-grouse lek counts as a function of oil and gas development since 1991.From 1991-2011 we found that oil and gas well-pad density increased 3.6-fold across the state and was associated with a 24% decline in the number of male sage-grouse. Using a spatial and temporally structured analysis via Geographically Weighted Regression, we found a 1-to-4 year time lag between development density and lek decline. Sage-grouse also responded to development densities at multiple spatial neighborhoods surrounding leks, including broad scales of 10 km. However, sage-grouse lek counts do not always decline as a result of oil and gas development. We found similar development densities resulting in different sage-grouse lek count responses, suggesting that development density alone is insufficient to predict the impacts that oil and gas development have on sage-grouse. Finally, our analysis suggests a maximum development density of 1 well-pad within 2 km of leks to avoid measurable impacts within 1 year, and <6 well-pads within 10 km of leks to avoid delayed impacts.

  19. SAGE (Summer of Applied Geophysical Experience): Learning Geophysics by Doing Geophysics

    Science.gov (United States)

    Jiracek, G. R.; Baldridge, W. S.; Biehler, S.; Braile, L. W.; Ferguson, J. F.; Gilpin, B. E.; Pellerin, L.

    2005-12-01

    SAGE, a field-based educational program in applied geophysical methods has been an REU site for 16 years and completed its 23rd year of operation in July 2005. SAGE teaches the major geophysical exploration methods (including seismics, gravity, magnetics, and electromagnetics) and applies them to the solution of specific local and regional geologic problems. These include delineating buried hazardous material; mapping archaeological sites; and studying the structure, tectonics, and water resources of the Rio Grande rift in New Mexico. Nearly 600 graduates, undergraduates, and professionals have attended SAGE since 1983. Since 1990 REU students have numbered 219 coming from dozens of different campuses. There have been 124 underrepresented REU students including 100 women, 14 Hispanics, 7 Native Americans, and 3 African Americans. Tracking of former REU students has revealed that 81% have gone on to graduate school. Keys to the success of SAGE are hands-on immersion in geophysics for one month and a partnership between academia, industry, and a federal laboratory. Successful approaches at SAGE include: 1) application of the latest equipment by all students; 2) continued updating of equipment, computers, and software by organizing universities and industry affiliates; 3) close ties with industry who provide supplemental instruction, furnish new equipment and software, and alert students to the current industry trends and job opportunities; 4) two-team, student data analysis structure that simultaneously addresses specific geophysical techniques and their integration; and 5) oral and written reports patterned after professional meetings and journals. An eight member, 'blue ribbon' advisory panel from academia, industry, and the federal government has been set up to maintain the vitality of SAGE by addressing such issues as funding, new faculty, organization, and vision. SAGE is open to students from any university (or organization) with backgrounds including

  20. Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.)

    OpenAIRE

    Walch, Stephan G.; Kuballa, Thomas; Stühlinger, Wolf; Lachenmeier, Dirk W.

    2011-01-01

    Abstract Background The sage plant Salvia officinalis L. is used as ingredient in foods and beverages as well as in herbal medicinal products. A major use is in the form of aqueous infusions as sage tea, which is legal to be sold as either food or medicine. Sage may contain two health relevant substances, thujone and camphor. The aim of this study was to develop and validate an analytical methodology to determine these active principles of sage and give a first overview of their concentration...

  1. 16 CFR 1130.8 - Requirements for Web site registration or alternative e-mail registration.

    Science.gov (United States)

    2010-01-01

    ... registration. (a) Link to registration page. The manufacturer's Web site, or other Web site established for the... web page that goes directly to “Product Registration.” (b) Purpose statement. The registration page... registration page. The Web site registration page shall request only the consumer's name, address, telephone...

  2. 21 CFR 1301.36 - Suspension or revocation of registration; suspension of registration pending final order...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Suspension or revocation of registration; suspension of registration pending final order; extension of registration pending final order. 1301.36... registration pending final order; extension of registration pending final order. (a) For any registration...

  3. Prospective MR image alignment between breath-holds: Application to renal BOLD MRI.

    Science.gov (United States)

    Kalis, Inge M; Pilutti, David; Krafft, Axel J; Hennig, Jürgen; Bock, Michael

    2017-04-01

    To present an image registration method for renal blood oxygen level-dependent (BOLD) measurements that enables semiautomatic assessment of parenchymal and medullary R2* changes under a functional challenge. In a series of breath-hold acquisitions, three-dimensional data were acquired initially for prospective image registration of subsequent BOLD measurements. An algorithm for kidney alignment for BOLD renal imaging (KALIBRI) was implemented to detect the positions of the left and right kidney so that the kidneys were acquired in the subsequent BOLD measurement at consistent anatomical locations. Residual in-plane distortions were corrected retrospectively so that semiautomatic dynamic R2* measurements of the renal cortex and medulla become feasible. KALIBRI was tested in six healthy volunteers during a series of BOLD experiments, which included a 600- to 1000-mL water challenge. Prospective image registration and BOLD imaging of each kidney was achieved within a total measurement time of about 17 s, enabling its execution within a single breath-hold. KALIBRI improved the registration by up to 35% as found with mutual information measures. In four volunteers, a medullary R2* decrease of up to 40% was observed after water ingestion. KALIBRI improves the quality of two-dimensional time-resolved renal BOLD MRI by aligning local renal anatomy, which allows for consistent R2* measurements over many breath-holds. Magn Reson Med 77:1573-1582, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  4. 31 CFR 800.217 - Hold.

    Science.gov (United States)

    2010-07-01

    ... and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF INVESTMENT... FOREIGN PERSONS Definitions § 800.217 Hold. The terms hold(s) and holding mean legal or beneficial ownership, whether direct or indirect, whether through fiduciaries, agents, or other means. ...

  5. SPECIALIZATION AND SUSTAINABLE DEVELOPMENT OF AGRICULTURAL HOLDINGS

    Directory of Open Access Journals (Sweden)

    Zofia Kołoszko-Chomentowska

    2016-03-01

    Full Text Available In the present article, an attempt was made to assess the sustainability of agricultural holdings with diff erent directions of production. Agricultural holdings in the Podlaskie voivodeship registered in the FADN system in 2011–2012 were investigated. Assessment accounted for agroecological indicators (share of permanent grasslands, share of cereals in crops, soil coverage with vegetation, stock density and economic indicators (profi tableness of land and labor. Analysis was conducted according to a classifi cation into agricultural holding types: fi eldcrops, dairy cattle, and granivores. Fieldcrop and granivore holdings achieved more favourable environmental sustainability indicators. Holdings specializing in dairy cattle breeding posed a threat to the natural environment, mainly due to their excessive stock density. Economic sustainability assessment showed that granivore holdings were assessed most favorably. In these holdings, holding income per full-time worker was 37% greater than in fi eldcrop holdings and 57% greater than in dairy cattle holdings.

  6. A feature selection approach for identification of signature genes from SAGE data

    Directory of Open Access Journals (Sweden)

    Silva Paulo JS

    2007-05-01

    Full Text Available Abstract Background One goal of gene expression profiling is to identify signature genes that robustly distinguish different types or grades of tumors. Several tumor classifiers based on expression profiling have been proposed using microarray technique. Due to important differences in the probabilistic models of microarray and SAGE technologies, it is important to develop suitable techniques to select specific genes from SAGE measurements. Results A new framework to select specific genes that distinguish different biological states based on the analysis of SAGE data is proposed. The new framework applies the bolstered error for the identification of strong genes that separate the biological states in a feature space defined by the gene expression of a training set. Credibility intervals defined from a probabilistic model of SAGE measurements are used to identify the genes that distinguish the different states with more reliability among all gene groups selected by the strong genes method. A score taking into account the credibility and the bolstered error values in order to rank the groups of considered genes is proposed. Results obtained using SAGE data from gliomas are presented, thus corroborating the introduced methodology. Conclusion The model representing counting data, such as SAGE, provides additional statistical information that allows a more robust analysis. The additional statistical information provided by the probabilistic model is incorporated in the methodology described in the paper. The introduced method is suitable to identify signature genes that lead to a good separation of the biological states using SAGE and may be adapted for other counting methods such as Massive Parallel Signature Sequencing (MPSS or the recent Sequencing-By-Synthesis (SBS technique. Some of such genes identified by the proposed method may be useful to generate classifiers.

  7. Microhabitat Conditions in Wyoming's Sage-Grouse Core Areas: Effects on Nest Site Selection and Success.

    Science.gov (United States)

    Dinkins, Jonathan B; Smith, Kurt T; Beck, Jeffrey L; Kirol, Christopher P; Pratt, Aaron C; Conover, Michael R

    2016-01-01

    The purpose of our study was to identify microhabitat characteristics of greater sage-grouse (Centrocercus urophasianus) nest site selection and survival to determine the quality of sage-grouse habitat in 5 regions of central and southwest Wyoming associated with Wyoming's Core Area Policy. Wyoming's Core Area Policy was enacted in 2008 to reduce human disturbance near the greatest densities of sage-grouse. Our analyses aimed to assess sage-grouse nest selection and success at multiple micro-spatial scales. We obtained microhabitat data from 928 sage-grouse nest locations and 819 random microhabitat locations from 2008-2014. Nest success was estimated from 924 nests with survival data. Sage-grouse selected nests with greater sagebrush cover and height, visual obstruction, and number of small gaps between shrubs (gap size ≥0.5 m and sage-grouse were selecting different nest sites in Core Areas relative to areas outside of Core. The Kaplan-Meier nest success estimate for a 27-day incubation period was 42.0% (95% CI: 38.4-45.9%). Risk of nest failure was negatively associated with greater rock and more medium-sized gaps between shrubs (gap size ≥2.0 m and <3.0 m). Within our study areas, Wyoming's Core Areas did not have differing microhabitat quality compared to outside of Core Areas. The close proximity of our locations within and outside of Core Areas likely explained our lack of finding differences in microhabitat quality among locations within these landscapes. However, the Core Area Policy is most likely to conserve high quality habitat at larger spatial scales, which over decades may have cascading effects on microhabitat quality available between areas within and outside of Core Areas.

  8. Antioxidant properties of biohybrids based on liposomes and sage silver nanoparticles.

    Science.gov (United States)

    Barbinta-Patrascu, Marcela Elisabeta; Bunghez, Ioana-Raluca; Iordache, Stefan Marian; Badea, Nicoleta; Fierascu, Radu-Claudiu; Ion, Rodica Mariana

    2013-03-01

    This paper is aimed to describe a simple and rapid eco-friendly bottom-up approach for the preparation of antioxidant silver bionanostructures using a leaf extract from sage (Salvia officinalis L.). The bioreduction property of sage in the synthesis of silver nanoparticles was investigated by UV-VIS and Attenuated Total Reflectance Fourier Transform Infrared spectroscopy. During their preparation, the particle size analysis was performed by using Dynamic Light Scattering technique. Ultrasonic irradiation was used to obtain sage silver nanoparticles. The morphology (size and shape) of the herbal silver nanoparticles was evaluated by Scanning Electron Microscopy that revealed the formation of spherical phytonanoparticles with size less than 80 nm. In order to increase their stability and their biocompatibility, the sage silver nanoparticles were introduced in two types of liposomes: soybean lecithin- and Chla-DPPC-lipid vesicles which were prepared by thin film hydration method. X-Ray Fluorescence analysis confirmed the silver presence in liposomes/sage-AgNPs biohybrids. The stability of liposomes/herbal AgNPs bioconstructs was checked by zeta potential measurements. The most stable biohybrids: Chla-DPPC/sage-AgNPs with zeta potential value of -34.2 mV, were characterized by Atomic Force Microscopy revealing the spherical and quasi-spherical shaped profiles of these nanobiohybrids with size less than 96 nm. The antioxidant activity of the silver bionanostructures was evaluated using chemiluminescence assay. The developed eco-friendly silver phytonanostructures based on lipid membranes, nanosilver and sage extract, manifest strong antioxidant properties (between 86.5% and 98.6%).

  9. Landscape characteristics and livestock presence influence common ravens: Relevance to greater sage-grouse conservation

    Science.gov (United States)

    Coates, Peter S.; Brussee, Brianne E.; Howe, Kristy; Gustafson, K. Ben; Casazza, Michael L.; Delehanty, David J.

    2016-01-01

    Common raven (Corvus corax; hereafter, raven) population abundance in the sagebrush steppe of the American West has increased threefold during the previous four decades, largely as a result of unintended resource subsidies from human land-use practices. This is concerning because ravens frequently depredate nests of species of conservation concern, such as greater sage-grouse (Centrocercus urophasianus; hereafter, sage-grouse). Grazing by livestock in sagebrush ecosystems is common practice on most public lands, but associations between livestock and ravens are poorly understood. The primary objective of this study was to identify the effects of livestock on raven occurrence while accounting for landscape characteristics within human-altered sagebrush steppe habitat, particularly in areas occupied by breeding sage-grouse. Using data from southeastern Idaho collected during spring and summer across 3 yr, we modeled raven occurrence as a function of the presence of livestock while accounting for multiple landscape covariates, including land cover features, topographical features, and proximity to sage-grouse lek sites (breeding grounds), as well as site-level anthropogenic features. While accounting for landscape characteristics, we found that the odds of raven occurrence increased 45.8% in areas where livestock were present. In addition, ravens selected areas near sage-grouse leks, with the odds of occurrence decreasing 8.9% for every 1-km distance, increase away from the lek. We did not find an association between livestock use and distance to lek. We also found that ravens selected sites with relatively lower elevation containing increased amounts of cropland, wet meadow, and urbanization. Limiting raven access to key anthropogenic subsidies and spatially segregating livestock from sage-grouse breeding areas would likely reduce exposure of predatory ravens to sage-grouse nests and chicks.

  10. Low footwall accelerations and variable surface rupture behavior on the Fort Sage Mountains fault, northeast California

    Science.gov (United States)

    Briggs, Richard W.; Wesnousky, Steven G.; Brune, James N.; Purvance, Matthew D.; Mahan, Shannon

    2013-01-01

    The Fort Sage Mountains fault zone is a normal fault in the Walker Lane of the western Basin and Range that produced a small surface rupture (L 5.6 earthquake in 1950. We investigate the paleoseismic history of the Fort Sage fault and find evidence for two paleoearthquakes with surface displacements much larger than those observed in 1950. Rupture of the Fort Sage fault ∼5.6  ka resulted in surface displacements of at least 0.8–1.5 m, implying earthquake moment magnitudes (Mw) of 6.7–7.1. An older rupture at ∼20.5  ka displaced the ground at least 1.5 m, implying an earthquake of Mw 6.8–7.1. A field of precariously balanced rocks (PBRs) is located less than 1 km from the surface‐rupture trace of this Holocene‐active normal fault. Ground‐motion prediction equations (GMPEs) predict peak ground accelerations (PGAs) of 0.2–0.3g for the 1950 rupture and 0.3–0.5g for the ∼5.6  ka paleoearthquake one kilometer from the fault‐surface trace, yet field tests indicate that the Fort Sage PBRs will be toppled by PGAs between 0.1–0.3g. We discuss the paleoseismic history of the Fort Sage fault in the context of the nearby PBRs, GMPEs, and probabilistic seismic hazard maps for extensional regimes. If the Fort Sage PBRs are older than the mid‐Holocene rupture on the Fort Sage fault zone, this implies that current GMPEs may overestimate near‐fault footwall ground motions at this site.

  11. Simulations of linear and Hamming codes using SageMath

    Science.gov (United States)

    Timur, Tahta D.; Adzkiya, Dieky; Soleha

    2018-03-01

    Digital data transmission over a noisy channel could distort the message being transmitted. The goal of coding theory is to ensure data integrity, that is, to find out if and where this noise has distorted the message and what the original message was. Data transmission consists of three stages: encoding, transmission, and decoding. Linear and Hamming codes are codes that we discussed in this work, where encoding algorithms are parity check and generator matrix, and decoding algorithms are nearest neighbor and syndrome. We aim to show that we can simulate these processes using SageMath software, which has built-in class of coding theory in general and linear codes in particular. First we consider the message as a binary vector of size k. This message then will be encoded to a vector with size n using given algorithms. And then a noisy channel with particular value of error probability will be created where the transmission will took place. The last task would be decoding, which will correct and revert the received message back to the original message whenever possible, that is, if the number of error occurred is smaller or equal to the correcting radius of the code. In this paper we will use two types of data for simulations, namely vector and text data.

  12. Visualization of Atmospheric Water Vapor Data for SAGE

    Science.gov (United States)

    Kung, Mou-Liang; Chu, W. P. (Technical Monitor)

    2000-01-01

    The goal of this project was to develop visualization tools to study the water vapor dynamics using the Stratospheric Aerosol and Gas Experiment 11 (SAGE 11) water vapor data. During the past years, we completed the development of a visualization tool called EZSAGE, and various Gridded Water Vapor plots, tools deployed on the web to provide users with new insight into the water vapor dynamics. Results and experiences from this project, including papers, tutorials and reviews were published on the main Web page. Additional publishing effort has been initiated to package EZSAGE software for CD production and distribution. There have been some major personnel changes since Fall, 1998. Dr. Mou-Liang Kung, a Professor of Computer Science assumed the PI position vacated by Dr. Waldo Rodriguez who was on leave. However, former PI, Dr. Rodriguez continued to serve as a research adviser to this project to assure smooth transition and project completion. Typically in each semester, five student research assistants were hired and trained. Weekly group meetings were held to discuss problems, progress, new research direction, and activity planning. Other small group meetings were also held regularly for different objectives of this project. All student research assistants were required to submit reports for conference submission.

  13. Image Registration: A Necessary Evil

    Science.gov (United States)

    Bell, James; McLachlan, Blair; Hermstad, Dexter; Trosin, Jeff; George, Michael W. (Technical Monitor)

    1995-01-01

    Registration of test and reference images is a key component of nearly all PSP data reduction techniques. This is done to ensure that a test image pixel viewing a particular point on the model is ratioed by the reference image pixel which views the same point. Typically registration is needed to account for model motion due to differing airloads when the wind-off and wind-on images are taken. Registration is also necessary when two cameras are used for simultaneous acquisition of data from a dual-frequency paint. This presentation will discuss the advantages and disadvantages of several different image registration techniques. In order to do so, it is necessary to propose both an accuracy requirement for image registration and a means for measuring the accuracy of a particular technique. High contrast regions in the unregistered images are most sensitive to registration errors, and it is proposed that these regions be used to establish the error limits for registration. Once this is done, the actual registration error can be determined by locating corresponding points on the test and reference images, and determining how well a particular registration technique matches them. An example of this procedure is shown for three transforms used to register images of a semispan model. Thirty control points were located on the model. A subset of the points were used to determine the coefficients of each registration transform, and the error with which each transform aligned the remaining points was determined. The results indicate the general superiority of a third-order polynomial over other candidate transforms, as well as showing how registration accuracy varies with number of control points. Finally, it is proposed that image registration may eventually be done away with completely. As more accurate image resection techniques and more detailed model surface grids become available, it will be possible to map raw image data onto the model surface accurately. Intensity

  14. Pro Forma Registration of Companies

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2010-01-01

    The article analyses the view taken by Community law on companies' pro forma registration in another EU or EEA country. Community law recognises pro forma registration under company law, i.e. a brass plate is sufficient, whereas it does not recognise pro forma registration under tax law, i.......e. a brass plate is not sufficient. The article provides reasons for the differential treatment of the two contexts and clarifies the difference on the basis of the Hubbard criterion, in which it was ruled that the effectiveness of Community law cannot vary according to the various branches of national law....

  15. Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA.

    Science.gov (United States)

    Fox, Rebecca M; Vaishnavi, Aria; Maruyama, Rika; Andrew, Deborah J

    2013-05-01

    FoxA transcription factors play major roles in organ-specific gene expression, regulating, for example, glucagon expression in the pancreas, GLUT2 expression in the liver, and tyrosine hydroxylase expression in dopaminergic neurons. Organ-specific gene regulation by FoxA proteins is achieved through cooperative regulation with a broad array of transcription factors with more limited expression domains. Fork head (Fkh), the sole Drosophila FoxA family member, is required for the development of multiple distinct organs, yet little is known regarding how Fkh regulates tissue-specific gene expression. Here, we characterize Sage, a bHLH transcription factor expressed exclusively in the Drosophila salivary gland (SG). We show that Sage is required for late SG survival and normal tube morphology. We find that many Sage targets, identified by microarray analysis, encode SG-specific secreted cargo, transmembrane proteins, and the enzymes that modify these proteins. We show that both Sage and Fkh are required for the expression of Sage target genes, and that co-expression of Sage and Fkh is sufficient to drive target gene expression in multiple cell types. Sage and Fkh drive expression of the bZip transcription factor Senseless (Sens), which boosts expression of Sage-Fkh targets, and Sage, Fkh and Sens colocalize on SG chromosomes. Importantly, expression of Sage-Fkh target genes appears to simply add to the tissue-specific gene expression programs already established in other cell types, and Sage and Fkh cannot alter the fate of most embryonic cell types even when expressed early and continuously.

  16. Computer Registration Becoming Mandatory

    CERN Multimedia

    2003-01-01

    Following the decision by the CERN Management Board (see Weekly Bulletin 38/2003), registration of all computers connected to CERN's network will be enforced and only registered computers will be allowed network access. The implementation has started with the IT buildings, continues with building 40 and the Prevessin site (as of Tuesday 4th November 2003), and will cover the whole of CERN before the end of this year. We therefore recommend strongly that you register all your computers in CERN's network database (Ethernet and wire-less cards) as soon as possible without waiting for the access restriction to take force. This will allow you accessing the network without interruption and help IT service providers to contact you in case of problems (security problems, viruses, etc.) • Users WITH a CERN computing account register at: http://cern.ch/register/ (CERN Intranet page) • Visitors WITHOUT a CERN computing account (e.g. short term visitors) register at: http://cern.ch/registerVisitorComp...

  17. Computer Registration Becoming Mandatory

    CERN Multimedia

    2003-01-01

    Following the decision by the CERN Management Board (see Weekly Bulletin 38/2003), registration of all computers connected to CERN's network will be enforced and only registered computers will be allowed network access. The implementation has started with the IT buildings, continues with building 40 and the Prevessin site (as of Tuesday 4th November 2003), and will cover the whole of CERN before the end of this year. We therefore recommend strongly that you register all your computers in CERN's network database including all network access cards (Ethernet AND wireless) as soon as possible without waiting for the access restriction to take force. This will allow you accessing the network without interruption and help IT service providers to contact you in case of problems (e.g. security problems, viruses, etc.) Users WITH a CERN computing account register at: http://cern.ch/register/ (CERN Intranet page) Visitors WITHOUT a CERN computing account (e.g. short term visitors) register at: http://cern.ch/regis...

  18. Greater sage-grouse science (2015–17)—Synthesis and potential management implications

    Science.gov (United States)

    Hanser, Steven E.; Deibert, Patricia A.; Tull, John C.; Carr, Natasha B.; Aldridge, Cameron L.; Bargsten, Travis D.; Christiansen, Thomas J.; Coates, Peter S.; Crist, Michele R.; Doherty, Kevin E.; Ellsworth, Ethan A.; Foster, Lee J.; Herren, Vicki A.; Miller, Kevin H.; Moser, Ann; Naeve, Robin M.; Prentice, Karen L.; Remington, Thomas E.; Ricca, Mark A.; Shinneman, Douglas J.; Truex, Richard L.; Wiechman , Lief A.; Wilson, Dereck C.; Bowen, Zachary H.

    2018-02-15

    Executive SummaryThe greater sage-grouse (Centrocercus urophasianus; hereafter called “sage-grouse”), a species that requires sagebrush (Artemisia spp.), has experienced range-wide declines in its distribution and abundance. These declines have prompted substantial research and management investments to improve the understanding of sage-grouse and its habitats and reverse declines in distribution and population numbers.Over the past two decades, the U.S. Fish and Wildlife Service (USFWS) has responded to eight petitions to list the sage-grouse under the Endangered Species Act of 1973, with the completion of the most recent listing determination in September 2015. At that time, the USFWS determined that the sage-grouse did not warrant a listing, primarily because of the large scale science-based conservation and planning efforts completed or started by Federal, State, local agencies, private landowners, and other entities across the range. The planning efforts culminated in the development of the 2015 Bureau of Land Management (BLM) and U.S. Forest Service Land Use Plan Amendments, which provided regulatory certainty and commitment from Federal land-management agencies to limit, mitigate, and track anthropogenic disturbance and implement other sage-grouse conservation measures.After these policy decisions, the scientific community has continued to refine and expand the knowledge available to inform implementation of management actions, increase the efficiency and effectiveness of those actions, and continue developing an overall understanding of sage-grouse populations, habitat requirements, and their response to human activity and other habitat changes. The development of science has been driven by multiple prioritization documents including the “Greater Sage-Grouse National Research Strategy” (Hanser and Manier, 2013) and, most recently, the “Integrated Rangeland Fire Management Strategy Actionable Science Plan” (Integrated Rangeland Fire Management

  19. Implementing reflection: insights from pre-registration mental health students.

    Science.gov (United States)

    Donovan, Moira O

    2007-08-01

    Reflection and reflective practice continues to be contentious issues in nursing. The focus of this article is the use of reflection by pre-registration mental health students. The broad aim of this preliminary study was to discover student mental health nurses' perceptions of reflection as a learning strategy during clinical placement. Using a constructivist grounded theory methodology [Charmaz, K., 2000. Grounded theory: Objectivist and Constructivist Methods. In: Denzin, N., Lincoln, Y. (Eds.), Handbook of Qualitative Research, second ed. Sage, Thousand Oaks, California], five students were interviewed individually in their clinical placements. Data analysis revealed three major categories: understanding the process of reflection, using reflection in clinical practice, and needing support and guidance. Findings indicated that students were primarily using reflection-on-action, but to varying extents. Overall, students felt that reflection facilitated their learning. Factors were discovered that both helped and hindered students' use of reflection. These included level of preparation to reflect, a limited culture of reflection and the level of support from preceptors, clinical staff, clinical placement co-ordinators, and lecturers. In conclusion, it appears that a collaborative approach between students, Health Service Providers and institutes of nursing is vital for the successful development and implementation of reflective learning strategies in clinical placement. Suggestions are made as to how a collaborative approach may be developed to enhance this process.

  20. Using resilience and resistance concepts to manage threats to sagebrush ecosystems, Gunnison sage-grouse, and Greater sage-grouse in their eastern range: A strategic multi-scale approach

    Science.gov (United States)

    Jeanne C. Chambers; Jeffrey L. Beck; Steve Campbell; John Carlson; Thomas J. Christiansen; Karen J. Clause; Jonathan B. Dinkins; Kevin E. Doherty; Kathleen A. Griffin; Douglas W. Havlina; Kenneth F. Henke; Jacob D. Hennig; Laurie L. Kurth; Jeremy D. Maestas; Mary Manning; Kenneth E. Mayer; Brian A. Mealor; Clinton McCarthy; Marco A. Perea; David A. Pyke

    2016-01-01

    This report provides a strategic approach developed by a Western Association of Fish and Wildlife Agencies interagency working group for conservation of sagebrush ecosystems, Greater sage-grouse, and Gunnison sage-grouse. It uses information on (1) factors that influence sagebrush ecosystem resilience to disturbance and resistance to nonnative invasive annual grasses...

  1. Using resilience and resistance concepts to manage threats to sagebrush ecosystems, Gunnison sage-grouse, and Greater sage-grouse in their eastern range: A strategic multi-scale approach

    Science.gov (United States)

    Chambers, Jeanne C.; Beck, Jeffrey L.; Campbell, Steve; Carlson, John; Christiansen, Thomas J.; Clause, Karen J.; Dinkins, Jonathan B.; Doherty, Kevin E.; Griffin, Kathleen A.; Havlina, Douglas W.; Mayer, Kenneth F.; Hennig, Jacob D.; Kurth, Laurie L.; Maestas, Jeremy D.; Manning, Mary E.; Mealor, Brian A.; McCarthy, Clinton; Perea, Marco A.; Pyke, David A.

    2016-01-01

    This report provides a strategic approach developed by a Western Association of Fish and Wildlife Agencies interagency working group for conservation of sagebrush ecosystems, Greater sage-grouse, and Gunnison sage-grouse. It uses information on (1) factors that influence sagebrush ecosystem resilience to disturbance and resistance to nonnative invasive annual grasses and (2) distribution and relative abundance of sage-grouse populations to address persistent ecosystem threats, such as invasive annual grasses and wildfire, and land use and development threats, such as oil and gas development and cropland conversion, to develop effective management strategies. A sage-grouse habitat matrix links relative resilience and resistance of sagebrush ecosystems with modeled sage-grouse breeding habitat probabilities to help decisionmakers assess risks and determine appropriate management strategies at both landscape and site scales. Areas for targeted management are assessed by overlaying matrix components with Greater sage-grouse Priority Areas for Conservation and Gunnison sage-grouse critical habitat and linkages, breeding bird concentration areas, and specific habitat threats. Decision tools are discussed for determining the suitability of target areas for management and the most appropriate management actions. A similar approach was developed for the Great Basin that was incorporated into the Federal land use plan amendments and served as the basis of a Bureau of Land Management Fire and Invasives Assessment Tool, which was used to prioritize sage-grouse habitat for targeted management activities.

  2. Investigating impacts of oil and gas development on greater sage-grouse

    Science.gov (United States)

    Green, Adam; Aldridge, Cameron L.; O'Donnell, Michael

    2017-01-01

    The sagebrush (Artemisia spp.) ecosystem is one of the largest ecosystems in western North America providing habitat for species found nowhere else. Sagebrush habitats have experienced dramatic declines since the 1950s, mostly due to anthropogenic disturbances. The greater sage-grouse (Centrocercus urophasianus) is a sagebrush-obligate species that has experienced population declines over the last several decades, which are attributed to a variety of disturbances including the more recent threat of oil and gas development. We developed a hierarchical, Bayesian state-space model to investigate the impacts of 2 measures of oil and gas development, and environmental and habitat conditions, on sage-grouse populations in Wyoming, USA using male lek counts from 1984 to 2008. Lek attendance of male sage-grouse declined by approximately 2.5%/year and was negatively related to oil and gas well density. We found little support for the influence of sagebrush cover and precipitation on changes in lek counts. Our results support those of other studies reporting negative impacts of oil and gas development on sage-grouse populations and our modeling approach allowed us to make inference to a longer time scale and larger spatial extent than in previous studies. In addition to sage-grouse, development may also negatively affect other sagebrush-obligate species, and active management of sagebrush habitats may be necessary to maintain some species. 

  3. The effect of clary sage oil on staphylococci responsible for wound infections.

    Science.gov (United States)

    Sienkiewicz, Monika; Głowacka, Anna; Poznańska-Kurowska, Katarzyna; Kaszuba, Andrzej; Urbaniak, Anna; Kowalczyk, Edward

    2015-02-01

    The spreading of bacterial antibiotic resistance among clinical strains of pathogenic bacteria has made investigators to search for other active antibacterial agents which could provide a valuable complement to the existing therapies. To determine the antibacterial activity of clary sage oil (Salvia sclarea L.) against Staphylococcus clinical strains which were isolated from patients with wound infections. A comprehensive evaluation of Staphylococcus clinical strain resistance to antibiotics was performed. The constituents of clary sage oil were assayed by GC-FID-MS analysis. The minimal inhibitory concentration (MIC) of the tested essential oil against staphylococci by the micro-dilution broth method was determined. The clary sage oil was active against Staphylococcus aureus, S. epidermidis and S. xylosus with MIC values ranging from 3.75 to 7.00 µl/ml. The results of the in vitro tests encourage to use formulations containing sage oil as the active natural antimicrobial agent. Because of its antimicrobial properties clary sage oil may be applied to treat wounds and skin infections.

  4. Mapping SAGE questionnaire to the International Classification of Functioning, Disability and Health (ICF).

    Science.gov (United States)

    Raggi, Alberto; Quintas, Rui; Russo, Emanuela; Martinuzzi, Andrea; Costardi, Daniela; Frisoni, Giovanni Battista; Franco, Maria Grazia; Andreotti, Alessandra; Ojala, Matti; Peña, Sebastián; Perales, Jaime; Chatterji, Somnath; Miret, Marta; Tobiasz-Adamczyk, Beata; Koskinen, Seppo; Frattura, Lucilla; Leonardi, Matilde

    2014-01-01

    The collaborative research on ageing in Europe protocol was based on that of the World Health Organization Study on global AGEing and adult health (SAGE) project that investigated the relationship between health and well-being and provided a set of instruments that can be used across countries to monitor health and health-related outcomes of older populations as well as the strategies for addressing issues concerning the ageing process. To evaluate the degree to which SAGE protocol covered the spectrum of disability given the scope of the World Health Organization International Classification of Functioning, Disability and Health (ICF), a mapping exercise was performed with SAGE protocol. Results show that the SAGE protocol covers ICF domains in a non-uniform way, with environmental factors categories being underrepresented, whereas mental, cardiovascular, sensory functions and mobility were overrepresented. To overcome this partial coverage of ICF functioning categories, new assessment instruments have been developed. PRACTITIONER MESSAGE: Mapping exercises are valid procedures to understand the extent to which a survey protocol covers the spectrum of functioning. The mapping exercise with SAGE protocol shows that it provides only a partial representation of body functions and activities and participation domains, and the coverage of environmental factors is poor. New instruments are therefore needed for researchers to properly understand the health and disability of ageing populations. Copyright © 2013 John Wiley & Sons, Ltd.

  5. Patterns in Greater Sage-grouse population dynamics correspond with public grazing records at broad scales.

    Science.gov (United States)

    Monroe, Adrian P; Aldridge, Cameron L; Assal, Timothy J; Veblen, Kari E; Pyke, David A; Casazza, Michael L

    2017-06-01

    Human land use, such as livestock grazing, can have profound yet varied effects on wildlife interacting within common ecosystems, yet our understanding of land-use effects is often generalized from short-term, local studies that may not correspond with trends at broader scales. Here we used public land records to characterize livestock grazing across Wyoming, USA, and we used Greater Sage-grouse (Centrocercus urophasianus) as a model organism to evaluate responses to livestock management. With annual counts of male Sage-grouse from 743 leks (breeding display sites) during 2004-2014, we modeled population trends in response to grazing level (represented by a relative grazing index) and timing across a gradient in vegetation productivity as measured by the Normalized Vegetation Difference Index (NDVI). We found grazing can have both positive and negative effects on Sage-grouse populations depending on the timing and level of grazing. Sage-grouse populations responded positively to higher grazing levels after peak vegetation productivity, but populations declined when similar grazing levels occurred earlier, likely reflecting the sensitivity of cool-season grasses to grazing during peak growth periods. We also found support for the hypothesis that effects of grazing management vary with local vegetation productivity. These results illustrate the importance of broad-scale analyses by revealing patterns in Sage-grouse population trends that may not be inferred from studies at finer scales, and could inform sustainable grazing management in these ecosystems. © 2017 by the Ecological Society of America.

  6. Colon Cancer Chemoprevention by Sage Tea Drinking: Decreased DNA Damage and Cell Proliferation.

    Science.gov (United States)

    Pedro, Dalila F N; Ramos, Alice A; Lima, Cristovao F; Baltazar, Fatima; Pereira-Wilson, Cristina

    2016-02-01

    Salvia officinalis and some of its isolated compounds have been found to be preventive of DNA damage and increased proliferation in vitro in colon cells. In the present study, we used the azoxymethane model to test effects of S. officinalis on colon cancer prevention in vivo. The results showed that sage treatment reduced the number of ACF formed only if administered before azoxymethane injection, demonstrating that sage tea drinking has a chemopreventive effect on colorectal cancer. A decrease in the proliferation marker Ki67 and in H2 O2 -induced and azoxymethane-induced DNA damage to colonocytes and lymphocytes were found with sage treatment. This confirms in vivo the chemopreventive effects of S. officinalis. Taken together, our results show that sage treatment prevented initiation phases of colon carcinogenesis, an effect due, at least in part, to DNA protection, and reduced proliferation rates of colon epithelial cell that prevent mutations and their fixation through cell replication. These chemopreventive effects of S. officinalis on colon cancer add to the many health benefits attributed to sage and encourage its consumption. Copyright © 2015 John Wiley & Sons, Ltd.

  7. Better living through conifer removal: A demographic analysis of sage-grouse vital rates.

    Directory of Open Access Journals (Sweden)

    John P Severson

    Full Text Available Sagebrush (Artemisia spp. obligate wildlife species such as the imperiled greater sage-grouse (Centrocercus urophasianus face numerous threats including altered ecosystem processes that have led to conifer expansion into shrub-steppe. Conifer removal is accelerating despite a lack of empirical evidence on grouse population response. Using a before-after-control-impact design at the landscape scale, we evaluated effects of conifer removal on two important demographic parameters, annual survival of females and nest survival, by monitoring 219 female sage-grouse and 225 nests in the northern Great Basin from 2010 to 2014. Estimates from the best treatment models showed positive trends in the treatment area relative to the control area resulting in an increase of 6.6% annual female survival and 18.8% nest survival relative to the control area by 2014. Using stochastic simulations of our estimates and published demographics, we estimated a 25% increase in the population growth rate in the treatment area relative to the control area. This is the first study to link sage-grouse demographics with conifer removal and supports recommendations to actively manage conifer expansion for sage-grouse conservation. Sage-grouse have become a primary catalyst for conservation funding to address conifer expansion in the West, and these findings have important implications for other ecosystem services being generated on the wings of species conservation.

  8. Ecology of Greater Sage-Grouse in the Bi-State Planning Area Final Report, September 2007

    Science.gov (United States)

    Casazza, Michael L.; Overton, Cory T.; Farinha, Melissa A.; Torregrosa, Alicia; Fleskes, Joseph P.; Miller, Michael R.; Sedinger, James S.; Kolada, Eric J.

    2009-01-01

    Conservation efforts for greater sage-grouse (Centrocercus urophasianus), hereafter sage-grouse, are underway across the range of this species. Over 70 local working groups have been established and are implementing on-the-ground sage-grouse oriented conservation projects. Early on in this process, the California Department of Fish and Game (CDFG) recognized the need to join in these efforts and received funding from the U.S. Fish and Wildlife Service (USFWS) under the Candidate Species Conservation Program to help develop a species conservation plan for sage-grouse in the Mono County area. This conservation plan covers portions of Alpine, Mono, and Inyo counties in California and Douglas, Esmeralda, Lyon, and Mineral counties in Nevada. A concurrent effort underway through the Nevada Governor's Sage-grouse Conservation Team established Local Area Working Groups across Nevada and eastern California. The Mono County populations of sage-grouse were encompassed by the Bi-State Local Planning Area, which was comprised of six population management units (PMUs). The state agencies from California (CDFG) and Nevada (Nevada Department of Wildlife; NDOW) responsible for the management of sage-grouse agreed to utilize the process that had begun with the Nevada Governor's Team in order to develop local plans for conservation planning and implementation. Resources from the USFWS were applied to several objectives in support of the development of the Bi-State Local Area Sage-grouse Conservation Plan through a grant to the U.S. Geological Survey (USGS). Objectives included: (1) participate in the development of the Bi-State Conservation Plan, (2) compile and synthesize existing sage-grouse data, (3) document seasonal movements of sage-grouse, (4) identify habitats critical to sage-grouse, (5) determine survival rates and identify causal factors of mortality, (6) determine nest success and brood success of sage-grouse, and (7) identify sage-grouse lek sites. Progress reports

  9. 17 CFR 239.13 - Form S-3, for registration under the Securities Act of 1933 of securities of certain issuers...

    Science.gov (United States)

    2010-04-01

    ... predecessor or forming a holding company and that the assets and liabilities of the successor at the time of... posted on its corporate Web site, if any, all Interactive Data Files required to be submitted and posted... offerings by certain registrants. Securities to be offered for cash by or on behalf of a registrant, or...

  10. Drug Establishments Current Registration Site

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Drug Establishments Current Registration Site (DECRS) is a database of current information submitted by drug firms to register establishments (facilities) which...

  11. Individual Pesticides in Registration Review

    Science.gov (United States)

    You can used the Chemical Search database to search pesticides by chemical name and find their registration review dockets, along with Work Plans, risk assessments, interim and final decisions, tolerance rules, and cancellation actions.

  12. Spherical Demons: Fast Surface Registration

    Science.gov (United States)

    Yeo, B.T. Thomas; Sabuncu, Mert; Vercauteren, Tom; Ayache, Nicholas; Fischl, Bruce; Golland, Polina

    2009-01-01

    We present the fast Spherical Demons algorithm for registering two spherical images. By exploiting spherical vector spline interpolation theory, we show that a large class of regularizers for the modified demons objective function can be efficiently implemented on the sphere using convolution. Based on the one parameter subgroups of diffeomorphisms, the resulting registration is diffeomorphic and fast – registration of two cortical mesh models with more than 100k nodes takes less than 5 minutes, comparable to the fastest surface registration algorithms. Moreover, the accuracy of our method compares favorably to the popular FreeSurfer registration algorithm. We validate the technique in two different settings: (1) parcellation in a set of in-vivo cortical surfaces and (2) Brodmann area localization in ex-vivo cortical surfaces. PMID:18979813

  13. Do More Economists Hold Stocks?

    DEFF Research Database (Denmark)

    Christiansen, Charlotte; Joensen, Juanna Schröter; Rangvid, Jesper

    A unique data set enables us to test the hypothesis that more economists than otherwise identical investors hold stocks due to informational advantages. We confirm that economists have a significantly higher probability of participating in the stock market than investors with any other education......, even when controlling for several background characteristics. We make use of a large register-based panel data set containing detailed information on the educational attainments and various financial and socioeconomic variables. We model the stock market participation decision by the probit model...

  14. Registration accuracy and image quality of time averaged mid-position CT scans for liver SBRT

    NARCIS (Netherlands)

    Kruis, Matthijs F.; van de Kamer, Jeroen B.; Sonke, Jan-Jakob; Jansen, Edwin P. M.; van Herk, Marcel

    2013-01-01

    The purpose was to validate the accuracy of motion models derived from deformable registration from four-dimensional computed tomography (4DCT) and breath-hold contrast enhanced computed tomography (BHCCT) scans for liver SBRT. Additionally, the image quality of the time averaged mid-position (MidP)

  15. Report on the Work of the Arms Registration and Marking Project in West Darfur

    NARCIS (Netherlands)

    Faltas, Sami

    After the war in Darfur, military weapons have proliferated and are used in various forms of violence. The government of Sudan is asking traditional leaders to get their followers to submit the weapons they hold for marking and registration. The report looks at this project in West Darfur and comes

  16. Surface membrane based bladder registration for evaluation of accumulated dose during brachytherapy in cervical cancer

    DEFF Research Database (Denmark)

    Noe, Karsten Østergaard; Tanderup, Kari; Sørensen, Thomas Sangild

    2011-01-01

    of the fixed surface. Optional landmark based matches can be included in the suggested iterative solver. The technique is demonstrated for bladder registration in brachytherapy treatment evaluation of cervical cancer. It holds promise to better estimate the accumulated but unintentional dose delivered...

  17. Greater sage-grouse: general use and roost site occurrence with pellet counts as a measure of relative abundance

    Science.gov (United States)

    Steven E. Hanser; Cameron L. Aldridge; Matthias Leu; Mary M. Rowland; Scott E. Nielsen; Steven T. Knick

    2011-01-01

    Greater sage-grouse (Centrocercus urophasianus) have been declining both spatially and numerically throughout their range because of anthropogenic disturbance and loss and fragmentation of sagebrush (Artemisia spp.) habitats. Understanding how sage-grouse respond to these habitat alterations and disturbances, particularly the...

  18. Conservation and restoration of sagebrush ecosystems and sage-grouse: An assessment of USDA Forest Service Science

    Science.gov (United States)

    Deborah M. Finch; Douglas A. Boyce; Jeanne C. Chambers; Chris J. Colt; Kas Dumroese; Stanley G. Kitchen; Clinton McCarthy; Susan E. Meyer; Bryce A. Richardson; Mary M. Rowland; Mark A. Rumble; Michael K. Schwartz; Monica S. Tomosy; Michael J. Wisdom

    2016-01-01

    Sagebrush ecosystems are among the largest and most threatened ecosystems in North America. Greater sage-grouse has served as the bellwether for species conservation in these ecosystems and has been considered for listing under the Endangered Species Act eight times. In September 2015, the decision was made not to list greater sage-grouse, but to reevaluate its status...

  19. USAGE: a web-based approach towards the analysis of SAGE data. Serial Analysis of Gene Expression

    NARCIS (Netherlands)

    van Kampen, A. H.; van Schaik, B. D.; Pauws, E.; Michiels, E. M.; Ruijter, J. M.; Caron, H. N.; Versteeg, R.; Heisterkamp, S. H.; Leunissen, J. A.; Baas, F.; van der Mee, M.

    2000-01-01

    MOTIVATION: SAGE enables the determination of genome-wide mRNA expression profiles. A comprehensive analysis of SAGE data requires software, which integrates (statistical) data analysis methods with a database system. Furthermore, to facilitate data sharing between users, the application should

  20. The Sagebrush Steppe Treatment Evaluation Project (SageSTEP): a test of state-and-transition theory

    Science.gov (United States)

    James D. McIver; Mark Brunson; Steve C. Bunting; Jeanne Chambers; Nora Devoe; Paul Doescher; James Grace; Dale Johnson; Steve Knick; Richard Miller; Mike Pellant; Fred Pierson; David Pyke; Kim Rollins; Bruce Roundy; Eugene Schupp; Robin Tausch; David Turner

    2010-01-01

    The Sagebrush Steppe Treatment Evaluation Project (SageSTEP) is a comprehensive, integrated, long-term study that evaluates the ecological effects of fire and fire surrogate treatments designed to reduce fuel and to restore sagebrush (Artemisia spp.) communities of the Great Basin and surrounding areas. SageSTEP has several features that make it ideal for testing...

  1. A first step toward uncovering the truth about weight tuning in deformable image registration

    Science.gov (United States)

    Pirpinia, Kleopatra; Bosman, Peter A. N.; Sonke, Jan-Jakob; van Herk, Marcel; Alderliesten, Tanja

    2016-03-01

    Deformable image registration is currently predominantly solved by optimizing a weighted linear combination of objectives. Successfully tuning the weights associated with these objectives is not trivial, leading to trial-and-error approaches. Such an approach assumes an intuitive interplay between weights, optimization objectives, and target registration errors. However, it is not known whether this always holds for existing registration methods. To investigate the interplay between weights, optimization objectives, and registration errors, we employ multi-objective optimization. Here, objectives of interest are optimized simultaneously, causing a set of multiple optimal solutions to exist, called the optimal Pareto front. Our medical application is in breast cancer and includes the challenging prone-supine registration problem. In total, we studied the interplay in three different ways. First, we ran many random linear combinations of objectives using the well-known registration software elastix. Second, since the optimization algorithms used in registration are typically of a local-search nature, final solutions may not always form a Pareto front. We therefore employed a multi-objective evolutionary algorithm that finds weights that correspond to registration outcomes that do form a Pareto front. Third, we examined how the interplay differs if a true multi-objective (i.e., weight-free) image registration method is used. Results indicate that a trial-and-error weight-adaptation approach can be successful for the easy prone to prone breast image registration case, due to the absence of many local optima. With increasing problem difficulty the use of more advanced approaches can be of value in finding and selecting the optimal registration outcomes.

  2. Effect of γ-irradiation on bioactivity, fatty acid compositions and volatile compounds of clary sage seed (Salvia sclarea L.).

    Science.gov (United States)

    Yalcin, Hasan; Ozturk, Ismet; Tulukcu, Eray; Sagdic, Osman

    2011-09-01

    Clary sage seeds (Salvia sclarea L.) were obtained from plants cultivated, and 2.5, 4.0, 5.5, and 7.0 kGy doses of γ-irradiation were applied to the clary sage seeds. They were then analyzed for their protein, ash, oil and dry matter contents, and fatty acid composition. Additionally, the total phenolic contents, antiradical, antioxidant activities, and volatile compounds of the clary sage seed extract were determined. There was no significant difference in protein content. However, the moisture, oil, and ash contents of the samples were affected by irradiation. While the 7 kGy dose had a positive effect on the total phenolic content and antiradical activity of the sage seed extract, all doses have negative effects on the antioxidant activity of the sage seed. The main fatty acid of the sage seed was remarkably found as α-linolenic acid. The four irradiation levels caused significant differences in fatty acid composition by affecting all fatty acids except palmitic, palmitoleic, and eicosenoic acids. The dominant volatile compounds of control sage seed were found as β-pinene (18.81%) and limonene (15.60%). Higher doses of the irradiation decreased volatile components of sage seed. Clary sage seed including high omega-3 can be irradiated with low doses (≤ 2.5 kGy) of γ-irradiation. Clary sage is one of the most popular Salvia species in Turkey and many countries. Clary sage seed has approximately 29% oil content and this oil contains >50% of α-linolenic acid. γ-Irradiation is widely applied in the preservation of spice quality. The present study shows that the antioxidant activity of the clary sage seed is decreased by γ-irradiation. Additionally, higher doses of irradiation also decreased the volatile components of sage seed. Therefore, we suggest that clary sage seed which includes high levels of omega-3 should be irradiated with low doses (≤ 2.5 kGy) of γ-irradiation. © 2011 Institute of Food Technologists®

  3. Comparison of aerosol extinction between lidar and SAGE II over Gadanki, a tropical station in India

    Directory of Open Access Journals (Sweden)

    P. Kulkarni

    2015-03-01

    Full Text Available An extensive comparison of aerosol extinction has been performed using lidar and Stratospheric Aerosol and Gas Experiment (SAGE II data over Gadanki (13.5° N, 79.2° E, a tropical station in India, following coincident criteria during volcanically quiescent conditions from 1998 to 2005. The aerosol extinctions derived from lidar are higher than SAGE II during all seasons in the upper troposphere (UT, while in the lower-stratosphere (LS values are closer. The seasonal mean percent differences between lidar and SAGE II aerosol extinctions are > 100% in the UT and Ba (sr−1, the ratio between aerosol backscattering and extinction, are needed for the tropics for a more accurate derivation of aerosol extinction.

  4. Brine saturation technique for extraction of light filth from rubbed, ground, and whole sage: collaborative study.

    Science.gov (United States)

    Freeman, C C

    1985-01-01

    A new approach to the isolation of light filth from the 3 commercial forms of sage was studied collaboratively. It incorporates a simple isopropanol defatting, followed by saturation of the product with brine by alternately heating and cooling, and subsequent trapping of filth from tap water with olive oil. This method circumvents the use of hazardous, expensive solvents and more time-consuming pretreatment procedures. Overall recoveries were 92.1% for rodent hair and 78.7% for insect fragments on clean, easy-to-read papers. An additional blending step was necessary to obtain satisfactory recovery of rodent hair fragments from whole sage. The method has been adopted official first action for light filth in rubbed and ground sage only.

  5. A Remote Registration Based on MIDAS

    Science.gov (United States)

    JIN, Xin

    2017-04-01

    We often need for software registration to protect the interests of the software developers. This article narrated one kind of software long-distance registration technology. The registration method is: place the registration information in a database table, after the procedure starts in check table registration information, if it has registered then the procedure may the normal operation; Otherwise, the customer must input the sequence number and registers through the network on the long-distance server. If it registers successfully, then records the registration information in the database table. This remote registration method can protect the rights of software developers.

  6. Phenology largely explains taller grass at successful nests in greater sage-grouse.

    Science.gov (United States)

    Smith, Joseph T; Tack, Jason D; Doherty, Kevin E; Allred, Brady W; Maestas, Jeremy D; Berkeley, Lorelle I; Dettenmaier, Seth J; Messmer, Terry A; Naugle, David E

    2018-01-01

    Much interest lies in the identification of manageable habitat variables that affect key vital rates for species of concern. For ground-nesting birds, vegetation surrounding the nest may play an important role in mediating nest success by providing concealment from predators. Height of grasses surrounding the nest is thought to be a driver of nest survival in greater sage-grouse ( Centrocercus urophasianus ; sage-grouse), a species that has experienced widespread population declines throughout their range. However, a growing body of the literature has found that widely used field methods can produce misleading inference on the relationship between grass height and nest success. Specifically, it has been demonstrated that measuring concealment following nest fate (failure or hatch) introduces a temporal bias whereby successful nests are measured later in the season, on average, than failed nests. This sampling bias can produce inference suggesting a positive effect of grass height on nest survival, though the relationship arises due to the confounding effect of plant phenology, not an effect on predation risk. To test the generality of this finding for sage-grouse, we reanalyzed existing datasets comprising >800 sage-grouse nests from three independent studies across the range where there was a positive relationship found between grass height and nest survival, including two using methods now known to be biased. Correcting for phenology produced equivocal relationships between grass height and sage-grouse nest survival. Viewed in total, evidence for a ubiquitous biological effect of grass height on sage-grouse nest success across time and space is lacking. In light of these findings, a reevaluation of land management guidelines emphasizing specific grass height targets to promote nest success may be merited.

  7. Allowance Holdings and Transfers Data Inventory

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Allowance Holdings and Transfers Data Inventory contains measured data on holdings and transactions of allowances under the NOx Budget Trading Program (NBP), a...

  8. Ultrasonic methods for locating hold-up

    International Nuclear Information System (INIS)

    Sinha, D.N.; Olinger, C.T.

    1995-01-01

    Hold-up remains one of the major contributing factors to unaccounted for materials and can be a costly problem in decontamination and decommissioning activities. Ultrasonic techniques are being developed to noninvasively monitor hold-up in process equipment where the inner surface of such equipment may be in contact with the hold-up material. These techniques may be useful in improving hold-up measurements as well as optimizing decontamination techniques

  9. Deep analysis of cellular transcriptomes – LongSAGE versus classic MPSS

    Directory of Open Access Journals (Sweden)

    Davis Simon J

    2007-09-01

    Full Text Available Abstract Background Deep transcriptome analysis will underpin a large fraction of post-genomic biology. 'Closed' technologies, such as microarray analysis, only detect the set of transcripts chosen for analysis, whereas 'open' e.g. tag-based technologies are capable of identifying all possible transcripts, including those that were previously uncharacterized. Although new technologies are now emerging, at present the major resources for open-type analysis are the many publicly available SAGE (serial analysis of gene expression and MPSS (massively parallel signature sequencing libraries. These technologies have never been compared for their utility in the context of deep transcriptome mining. Results We used a single LongSAGE library of 503,431 tags and a "classic" MPSS library of 1,744,173 tags, both prepared from the same T cell-derived RNA sample, to compare the ability of each method to probe, at considerable depth, a human cellular transcriptome. We show that even though LongSAGE is more error-prone than MPSS, our LongSAGE library nevertheless generated 6.3-fold more genome-matching (and therefore likely error-free tags than the MPSS library. An analysis of a set of 8,132 known genes detectable by both methods, and for which there is no ambiguity about tag matching, shows that MPSS detects only half (54% the number of transcripts identified by SAGE (3,617 versus 1,955. Analysis of two additional MPSS libraries shows that each library samples a different subset of transcripts, and that in combination the three MPSS libraries (4,274,992 tags in total still only detect 73% of the genes identified in our test set using SAGE. The fraction of transcripts detected by MPSS is likely to be even lower for uncharacterized transcripts, which tend to be more weakly expressed. The source of the loss of complexity in MPSS libraries compared to SAGE is unclear, but its effects become more severe with each sequencing cycle (i.e. as MPSS tag length increases

  10. Medical image registration for analysis

    International Nuclear Information System (INIS)

    Petrovic, V.

    2006-01-01

    Full text: Image registration techniques represent a rich family of image processing and analysis tools that aim to provide spatial correspondences across sets of medical images of similar and disparate anatomies and modalities. Image registration is a fundamental and usually the first step in medical image analysis and this paper presents a number of advanced techniques as well as demonstrates some of the advanced medical image analysis techniques they make possible. A number of both rigid and non-rigid medical image alignment algorithms of equivalent and merely consistent anatomical structures respectively are presented. The algorithms are compared in terms of their practical aims, inputs, computational complexity and level of operator (e.g. diagnostician) interaction. In particular, the focus of the methods discussion is placed on the applications and practical benefits of medical image registration. Results of medical image registration on a number of different imaging modalities and anatomies are presented demonstrating the accuracy and robustness of their application. Medical image registration is quickly becoming ubiquitous in medical imaging departments with the results of such algorithms increasingly used in complex medical image analysis and diagnostics. This paper aims to demonstrate at least part of the reason why

  11. Language proficiency and nursing registration.

    Science.gov (United States)

    Müller, Amanda

    2016-02-01

    This discussion paper focuses on English proficiency standards for nursing registration in Australia, how Australia has dealt with the issue of language proficiency, and the factors which have led to the establishment of the current language standards. Also, this paper will provide a comparison of the two language tests that are currently accepted in Australia (OET and IELTS), including the appropriateness of these tests and the minimum standards used. The paper will also examine the use of educational background as an indicator of language proficiency. Finally, communication-based complaints in the post-registration environment will be explored, and some discussion will be provided about why pre-registration measures might have failed to prevent such problematic situations from occurring. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Dual registration of abdominal motion for motility assessment in free-breathing data sets acquired using dynamic MRI

    International Nuclear Information System (INIS)

    Menys, A; Hamy, V; Makanyanga, J; Taylor, S A; Atkinson, D; Hoad, C; Gowland, P; Odille, F

    2014-01-01

    At present, registration-based quantification of bowel motility from dynamic MRI is limited to breath-hold studies. Here we validate a dual-registration technique robust to respiratory motion for the assessment of small bowel and colonic motility. Small bowel datasets were acquired in breath-hold and free-breathing in 20 healthy individuals. A pre-processing step using an iterative registration of the low rank component of the data was applied to remove respiratory motion from the free breathing data. Motility was then quantified with an existing optic-flow (OF) based registration technique to form a dual-stage approach, termed Dual Registration of Abdominal Motion (DRAM). The benefit of respiratory motion correction was assessed by (1) assessing the fidelity of automatically propagated segmental regions of interest (ROIs) in the small bowel and colon and (2) comparing parametric motility maps to a breath-hold ground truth. DRAM demonstrated an improved ability to propagate ROIs through free-breathing small bowel and colonic motility data, with median error decreased by 90% and 55%, respectively. Comparison between global parametric maps showed high concordance between breath-hold data and free-breathing DRAM. Quantification of segmental and global motility in dynamic MR data is more accurate and robust to respiration when using the DRAM approach. (paper)

  13. 78 FR 23162 - Supervision and Regulation Assessments for Bank Holding Companies and Savings and Loan Holding...

    Science.gov (United States)

    2013-04-18

    ... bank holding company's Consolidated Financial Statements for Bank Holding Companies (FR Y-9C) forms; \\3... Balance Sheet of the BHC's Consolidated Financial Statements for Bank Holding Companies (FR Y-9C) (OMB No... holding companies with $50 billion or more in total consolidated assets, and nonbank financial companies...

  14. Numerical methods for image registration

    CERN Document Server

    Modersitzki, Jan

    2003-01-01

    Based on the author's lecture notes and research, this well-illustrated and comprehensive text is one of the first to provide an introduction to image registration with particular emphasis on numerical methods in medical imaging. Ideal for researchers in industry and academia, it is also a suitable study guide for graduate mathematicians, computer scientists, engineers, medical physicists, and radiologists.Image registration is utilised whenever information obtained from different viewpoints needs to be combined or compared and unwanted distortion needs to be eliminated. For example, CCTV imag

  15. Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea).

    Science.gov (United States)

    Walch, Stephan G; Tinzoh, Laura Ngaba; Zimmermann, Benno F; Stühlinger, Wolf; Lachenmeier, Dirk W

    2011-01-01

    Sage (Salvia officinalis L.) is used as an herbal medicinal product, with the most typical form of application as infusion with boiling water (sage tea). The well-established traditional uses include symptomatic treatment of mild dyspeptic complaints, the treatment of inflammations in the mouth and the throat, and relief of excessive sweating and relief of minor skin inflammations. In this study, sage teas prepared from commercially available products were chemically analyzed for polyphenolic content using liquid chromatography, for antioxidant potential using the oxygen radical absorbance capacity method, and for the Folin-Ciocalteu (FC) index. The sage teas showed a high variation for all parameters studied (up to 20-fold differences for rosmarinic acid). Univariate and multivariate analyses showed that the antioxidant potential, which varied between 0.4 and 1.8 mmol trolox equivalents/100 mL, was highly dependent on rosmarinic acid and its derivatives. The FC index also showed a high correlation to these polyphenols, and could therefore be used as a screening parameter for sage tea quality. The considerable differences in polyphenolic composition and antioxidant capacity between the brands lead to a demand for quality standardization, especially if these sage teas are to be used for therapeutic purposes. Further research also appears to be necessary to characterize the dose-benefit relationship, as sage may also contain a constituent (thujone) with potentially adverse effects.

  16. Antioxidant capacity and polyphenolic composition as quality indicators for aqueous infusions of Salvia officinalis L. (sage tea

    Directory of Open Access Journals (Sweden)

    Stephan G Walch

    2011-12-01

    Full Text Available Sage (Salvia officinalis L. is used as an herbal medicinal product, with the most typical form of application as infusion with boiling water (sage tea. The well-established traditional uses include symptomatic treatment of mild dyspeptic complaints, the treatment of inflammations in the mouth and the throat, and relief of excessive sweating and relief of minor skin inflammations. In this study, sage teas prepared from commercially available products were chemically analysed for polyphenolic content using liquid chromatography, for antioxidant potential using the oxygen radical absorbance capacity (ORAC method, and for the Folin-Ciocalteu (FC index. The sage teas showed a high variation for all parameters studied (up to 20-fold differences for rosmarinic acid. Univariate and multivariate analyses showed that the antioxidant potential, which varied between 0.4 and 1.8 mmol trolox equivalents/100 mL, was highly dependent on rosmarinic acid and its derivatives. The FC index also showed a high correlation to these polyphenols, and could therefore be used as a screening parameter for sage tea quality. The considerable differences in polyphenolic composition and antioxidant capacity between the brands lead to a demand for quality standardisation, especially if these sage teas are to be used for therapeutic purposes. Further research also appears to be necessary to characterise the dose-benefit relationship, as sage may also contain a constituent (thujone with potentially adverse effects.

  17. Multi-species benefits of the proposed North American sage-grouse management plan

    Science.gov (United States)

    Clait E. Braun

    2005-01-01

    The population size and distribution of the two species of sage-grouse (Greater – Centrocercus urophasianus and Gunnison – C. minimus) populations have become greatly reduced throughout western North America because of habitat changes. Threats are ongoing to the remaining sagebrush (Artemisia ...

  18. Methodology optimizing SAGE library tag-to-gene mapping: application to Leishmania

    Directory of Open Access Journals (Sweden)

    Smandi Sondos

    2012-01-01

    Full Text Available Abstract Background Leishmaniasis are widespread parasitic-diseases with an urgent need for more active and less toxic drugs and for effective vaccines. Understanding the biology of the parasite especially in the context of host parasite interaction is a crucial step towards such improvements in therapy and control. Several experimental approaches including SAGE (Serial analysis of gene expression have been developed in order to investigate the parasite transcriptome organisation and plasticity. Usual SAGE tag-to-gene mapping techniques are inadequate because almost all tags are normally located in the 3'-UTR outside the CDS, whereas most information available for Leishmania transcripts is restricted to the CDS predictions. The aim of this work is to optimize a SAGE libraries tag-to-gene mapping technique and to show how this development improves the understanding of Leishmania transcriptome. Findings The in silico method implemented herein was based on mapping the tags to Leishmania genome using BLAST then mapping the tags to their gene using a data-driven probability distribution. This optimized tag-to-gene mappings improved the knowledge of Leishmania genome structure and transcription. It allowed analyzing the expression of a maximal number of Leishmania genes, the delimitation of the 3' UTR of 478 genes and the identification of biological processes that are differentially modulated during the promastigote to amastigote differentiation. Conclusion The developed method optimizes the assignment of SAGE tags in trypanosomatidae genomes as well as in any genome having polycistronic transcription and small intergenic regions.

  19. SAGE FOR WINDOWS (WSAGE) VERSION 1.0 SOLVENT ALTERNATIVES GUIDE - USER'S GUIDE

    Science.gov (United States)

    The guide provides instructions for using the Solvent Alternatives Guide (SAGE) for Windows, version 1.0. The guide assumes that the user is familiar with the fundamentals of operating Windows 3.1 (or higher) on a personal computer under the DOS 5.0 (or higher) operating system. ...

  20. Landscape restoration for greater sage-grouse: implications for multiscale planning and monitoring

    Science.gov (United States)

    Michael J. Wisdom; Mary M. Rowland; Miles A. Hemstrom; Barbara C. Wales

    2005-01-01

    Habitats and populations of greater sage-grouse (Centrocercus urophasianus) have declined throughout western North America in response to a myriad of detrimental land uses. Successful restoration of this species' habitat, therefore, is of keen interest to Federal land agencies who oversee management of most remaining habitat. To illustrate the...

  1. Salvia officinalis l. (sage) Ameliorates Radiation-Induced Oxidative Brain Damage In Rats

    International Nuclear Information System (INIS)

    Osman, N. N.; Abd El Azime, A.Sh.

    2013-01-01

    The present study was designed to investigate the oxidative stress and the role of antioxidant system in the management of gamma irradiation induced whole brain damage in rats . Also, to elucidate the potential role of Salvia officinalis (sage) in alleviating such negative effects. Rats were subjected to gamma radiation (6 Gy). Sage extract was daily given to rats during 14 days before starting irradiation and continued after radiation exposure for another 14 days. The results revealed that the levels of thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCC) and nitric oxide (NO) content were significantly increased, while the activities of superoxide dismutase (SOD) and catalase (CAT) as well as the reduced glutathione (GSH) content were significantly decreased in the brain homogenate of irradiated rats. Additionally, brain acetylcholinesterase (AChE) as well as alkaline phosphatase (ALP), acid phosphatase (ACP) and lactate dehydrogenase (LDH) activities were significantly increased. On the other hand, the results showed that, administration of sage extract to rats was able to ameliorate the mentioned parameters and the values returned close to the normal ones. It could be concluded that sage extract, by its antioxidant constituents, could modulate radiation induced oxidative stress and enzyme activities in the brain.

  2. SAGE SOLVENT ALTERNATIVES GUIDE: SYSTEM IMPROVEMENTS FOR SELECTING INDUSTRIAL SURFACE CLEANING ALTERNATIVES

    Science.gov (United States)

    The paper describes computer software, called SAGE, that can provide not only cleaning recommendations but also general information on various surface cleaning options. In short, it is an advisory system which can provide users with vital information on the cleaning process optio...

  3. Restoration handbook for sagebrush steppe ecosystems with emphasis on greater sage-grouse habitat - Part 1

    Science.gov (United States)

    David A. Pyke; Jeanne C. Chambers; Mike Pellant; Steven T. Knick; Richard F. Miller; Jeffrey L. Beck; Paul S. Doescher; Eugene W. Schupp; Bruce A. Roundy; Mark Brunson; James D. McIver

    2015-01-01

    Sagebrush steppe ecosystems in the United States currently occur on only about one-half of their historical land area because of changes in land use, urban growth, and degradation of land, including invasions of non-native plants. The existence of many animal species depends on the existence of sagebrush steppe habitat. The greater sage-grouse (Centrocercus...

  4. Hierarchical population structure in greater sage-grouse provides insight into management boundary delineation

    Science.gov (United States)

    Todd B. Cross; David E. Naugle; John C. Carlson; Michael K. Schwartz

    2016-01-01

    Understanding population structure is important for guiding ongoing conservation and restoration efforts. The greater sage-grouse (Centrocercus urophasianus) is a species of concern distributed across 1.2 million km2 of western North America. We genotyped 1499 greater sagegrouse from 297 leks across Montana, North Dakota and South Dakota using a 15 locus...

  5. Information Retrieval from SAGE II and MFRSR Multi-Spectral Extinction Measurements

    Science.gov (United States)

    Lacis, Andrew A.; Hansen, James E. (Technical Monitor)

    2001-01-01

    Direct beam spectral extinction measurements of solar radiation contain important information on atmospheric composition in a form that is essentially free from multiple scattering contributions that otherwise tend to complicate the data analysis and information retrieval. Such direct beam extinction measurements are available from the solar occultation satellite-based measurements made by the Stratospheric and Aerosol Gas Experiment (SAGE II) instrument and by ground-based Multi-Filter Shadowband Radiometers (MFRSRs). The SAGE II data provide cross-sectional slices of the atmosphere twice per orbit at seven wavelengths between 385 and 1020 nm with approximately 1 km vertical resolution, while the MFRSR data provide atmospheric column measurements at six wavelengths between 415 and 940 nm but at one minute time intervals. We apply the same retrieval technique of simultaneous least-squares fit to the observed spectral extinctions to retrieve aerosol optical depth, effective radius and variance, and ozone, nitrogen dioxide, and water vapor amounts from the SAGE II and MFRSR measurements. The retrieval technique utilizes a physical model approach based on laboratory measurements of ozone and nitrogen dioxide extinction, line-by-line and numerical k-distribution calculations for water vapor absorption, and Mie scattering constraints on aerosol spectral extinction properties. The SAGE II measurements have the advantage of being self-calibrating in that deep space provides an effective zero point for the relative spectral extinctions. The MFRSR measurements require periodic clear-day Langley regression calibration events to maintain accurate knowledge of instrument calibration.

  6. Greater sage-grouse as an umbrella species for sagebrush-associated vertebrates.

    Science.gov (United States)

    Mary M. Rowland; Michael J. Wisdom; Lowell Suring; Cara W. Meinke

    2006-01-01

    Widespread degradation of the sagebrush ecosystem in the western United States, including the invasion of cheatgrass, has prompted resource managers to consider a variety of approaches to restore and conserve habitats for sagebrush-associated species. One such approach involves the use of greater sage-grouse, a species of prominent conservation interest, as an umbrella...

  7. Metabolism of monoterpenes in cell cultures of common sage (Salvia officinalis)

    International Nuclear Information System (INIS)

    Falk, K.L.; Gershenzon, J.; Croteau, R.

    1990-01-01

    Leaves of common sage (Salvia officinalis) accumulate monoterpenes in glandular trichomes at levels exceeding 15 milligrams per gram fresh weight at maturity, whereas sage cells in suspension culture did not accumulate detectable levels of monoterpenes ( 14 C]sucrose was also virtually undetectable in this cell culture system. In vitro assay of each of the enzymes required for the sequential conversion of the ubiquitous isoprenoid precursor geranyl pyrophosphate to (+)-camphor (a major monoterpene product of sage) in soluble extracts of the cells revealed the presence of activity sufficient to produce (+)-camphor at a readily detectable level (>0.3 micrograms per gram fresh weight) at the late log phase of growth. Other monoterpene synthetic enzymes were present as well. In vivo measurement of the ability to catabolize (+)-camphor in these cells indicated that degradative capability exceeded biosynthetic capacity by at least 1,000-fold. Therefore, the lack of monoterpene accumulation in undifferentiated sage cultures could be attributed to a low level of biosynthetic activity (relative to the intact plant) coupled to a pronounced capacity for monoterpene catabolism

  8. Characteristics of coastal sage scrub in relation to fire history and use by California gnatcatchers

    Science.gov (United States)

    Jan L. Beyers; Ginger C. Pena

    1995-01-01

    Abstract: Plant cover and vegetation structure were examined at two inland coastal sage scrub sites differing in fire history and use by California gnatcatchers. Salvia mellifera and Eriogonum fasciculatum dominated one site; shrub cover on gnatcatcher occupied plots averaged 50 percent greater than on unoccupied plots. At the other site, gnatcatcher-occupied plots had...

  9. Revealing the Mind of the Sage: The Narrative Rhetoric of the "Chuang Tzu."

    Science.gov (United States)

    Kirkwood, William G.

    1992-01-01

    Argues that one of the formative texts of Taoism, the "Chuang Tzu," is worthy of study by rhetoric scholars because it reveals a unique approach to rhetoric in its attempt to disclose the mind of the sage not through logic but through intuition, and it shows how storytelling can acquaint people with previously unsuspected possibilities of thought…

  10. ALICE Holds Up to Challenge

    CERN Multimedia

    2006-01-01

    ALICE's main austenitic stainless steel support structure (the Space Frame) has recently gone through many tests that proved quite challenging: insuring the structure is sound and lowering it horizontally into the ALICE cavern. This structure is constructed to hold the large volume detectors, such as the Time Projection Chamber, Transition Radiation Detector and Time of Flight inside the ALICE solenoid magnet. After the final assembly at CERN, two large mobile cranes were needed for the job of lifting and turning the 14 tonne frame onto its side. Once shifted, it was placed in Building SX2, one of the surface assembly areas designated for ALICE. The structure, which is 8 m in diameter and 7 m long, underwent many tests in its new position. Geometric control tests were performed by measuring each of the 18 cells and placing wooden or metal samples constructed to the same dimensions as the real thing inside the structure. The most important check was the movement of the real Time Projection Chamber from its s...

  11. Microhabitat Conditions in Wyoming's Sage-Grouse Core Areas: Effects on Nest Site Selection and Success.

    Directory of Open Access Journals (Sweden)

    Jonathan B Dinkins

    Full Text Available The purpose of our study was to identify microhabitat characteristics of greater sage-grouse (Centrocercus urophasianus nest site selection and survival to determine the quality of sage-grouse habitat in 5 regions of central and southwest Wyoming associated with Wyoming's Core Area Policy. Wyoming's Core Area Policy was enacted in 2008 to reduce human disturbance near the greatest densities of sage-grouse. Our analyses aimed to assess sage-grouse nest selection and success at multiple micro-spatial scales. We obtained microhabitat data from 928 sage-grouse nest locations and 819 random microhabitat locations from 2008-2014. Nest success was estimated from 924 nests with survival data. Sage-grouse selected nests with greater sagebrush cover and height, visual obstruction, and number of small gaps between shrubs (gap size ≥0.5 m and <1.0 m, while selecting for less bare ground and rock. With the exception of more small gaps between shrubs, we did not find any differences in availability of these microhabitat characteristics between locations within and outside of Core Areas. In addition, we found little supporting evidence that sage-grouse were selecting different nest sites in Core Areas relative to areas outside of Core. The Kaplan-Meier nest success estimate for a 27-day incubation period was 42.0% (95% CI: 38.4-45.9%. Risk of nest failure was negatively associated with greater rock and more medium-sized gaps between shrubs (gap size ≥2.0 m and <3.0 m. Within our study areas, Wyoming's Core Areas did not have differing microhabitat quality compared to outside of Core Areas. The close proximity of our locations within and outside of Core Areas likely explained our lack of finding differences in microhabitat quality among locations within these landscapes. However, the Core Area Policy is most likely to conserve high quality habitat at larger spatial scales, which over decades may have cascading effects on microhabitat quality available

  12. Sagebrush, greater sage-grouse, and the occurrence and importance of forbs

    Science.gov (United States)

    Pennington, Victoria E.; Schlaepfer, Daniel R.; Beck, Jeffrey L.; Bradford, John B.; Palmquist, Kyle A.; Lauenroth, William K.

    2016-01-01

    Big sagebrush (Artemisia tridentata Nutt.) ecosystems provide habitat for sagebrush-obligate wildlife species such as the Greater Sage-Grouse (Centrocercus urophasianus). The understory of big sagebrush plant communities is composed of grasses and forbs that are important sources of cover and food for wildlife. The grass component is well described in the literature, but the composition, abundance, and habitat role of forbs in these communities is largely unknown. Our objective was to synthesize information about forbs and their importance to Greater Sage-Grouse diets and habitats, how rangeland management practices affect forbs, and how forbs respond to changes in temperature and precipitation. We also sought to identify research gaps and needs concerning forbs in big sagebrush plant communities. We searched for relevant literature including journal articles and state and federal agency reports. Our results indicated that in the spring and summer, Greater Sage-Grouse diets consist of forbs (particularly species in the Asteraceae family), arthropods, and lesser amounts of sagebrush. The diets transition to sagebrush in fall and winter. Forbs provide cover for Greater Sage-Grouse individuals at their lekking, nesting, and brood-rearing sites, and the species has a positive relationship with arthropod presence. The effect of grazing on native forbs may be compounded by invasion of nonnative species and differs depending on grazing intensity. The effect of fire on forbs varies greatly and may depend on time elapsed since burning. In addition, chemical and mechanical treatments affect annual and perennial forbs differently. Temperature and precipitation influence forb phenology, biomass, and abundance differently among species. Our review identified several uncertainties and research needs about forbs in big sagebrush ecosystems. First, in many cases the literature about forbs is reported only at the genus or functional type level. Second, information about forb

  13. The SAGE spectrometer: A tool for combined in-beam γ-ray and conversion electron spectroscopy

    International Nuclear Information System (INIS)

    Papadakis, P; Herzberg, R-D; Pakarinen, J; Butler, P A; Cox, D; Cresswell, J R; Parr, E; Sampson, J; Greenlees, P T; Sorri, J; Hauschild, K; Jones, P; Julin, R; Peura, P; Rahkila, P; Sandzelius, M; Coleman-Smith, P J; Lazarus, I H; Letts, S C; Pucknell, V F E

    2011-01-01

    The SAGE spectrometer allows simultaneous in-beam γ-ray and internal conversion electron measurements, by combining a germanium detector array with a highly segmented silicon detector and an electron transport system. SAGE is coupled with the ritu gas-filled recoil separator and the great focal-plane spectrometer for recoil-decay tagging studies. Digital electronics are used both for the γ ray and the electron parts of the spectrometer. SAGE was commissioned in the Accelerator Laboratory of the University of Jyvaeskylae in the beginning of 2010.

  14. Bioaccessibility and inhibitory effects on digestive enzymes of carnosic acid in sage and rosemary.

    Science.gov (United States)

    Ercan, Pınar; El, Sedef Nehir

    2018-04-28

    In this study, the aim was to determine the bioaccessibilities of carnosic acid in sage and rosemary and in vitro inhibitory effects of these samples on lipid and starch digestive enzymes by evaluating the lipase, α-amylase and α-glucosidase enzyme inhibition activities. The content of carnosic acid in rosemary (18.72 ± 0.33 mg/g) was found to be higher than that content of that in sage (3.76 ± 0.13 mg/g) (p sage and rosemary, respectively. The tested sage and rosemary showed inhibitory activity against α-glucosidase (Concentration of inhibitor required to produce a 50% inhibition of the initial rate of reaction - IC 50 88.49 ± 2.35, 76.80 ± 1.68 μg/mL, respectively), α-amylase (IC 50 107.65 ± 12.64, 95.65 ± 2.73 μg/mL, respectively) and lipase (IC 50 6.20 ± 0.63, 4.31 ± 0.62 μg/mL, respectively). Furthermore, to the best of our knowledge, this is the first work that carnosic acid standard equivalent inhibition capacities (CAEIC 50 ) for these food samples were determined and these values were in agreement with the IC 50 values. These results show that sage and rosemary are potent inhibitors of lipase, α-amylase and α-glucosidase digestive enzymes. Copyright © 2018 Elsevier B.V. All rights reserved.

  15. Gravity in the Century of Light: The Gravitation Theory of Georges-Louis Le Sage

    Science.gov (United States)

    Evans, James

    2006-05-01

    Each generation of physicists, or natural philosophers, has sought to place universal gravitation in the context of its own worldview. Often this has entailed an effort to reduce gravitation to something more fundamental. But what is deemed fundamental has, of course, changed with time. Each generation attacked the problem of universal gravitation with the tools of its day and brought to bear the concepts of its own standard model. The most successful eighteenth-century attempt to provide a mechanical explanation of gravity was that of Georges-Louis Le Sage (1724-1803) of Geneva. Le Sage postulated a sea of ultramundane corpuscles, streaming in all directions and characterized by minute mass, great velocity, and complete inelasticity. Mostly these corpuscles just pass through gross bodies such as apples or planets, but a few are absorbed, leading to all the phenomena of attraction. In a voluminous correspondence with nearly all the savants of the day, Le Sage constantly reshaped his arguments for his system in order to appeal to metaphysicians, mechanicians and Newtonians of several varieties. Le Sage's theory is an especially interesting one, for several reasons. First, it serves as the prototype of a dynamical explanation of Newtonian gravity. Second, the theory came quite close to accomplishing its aim. Third, the theory had a long life and attracted comment by the leading physical thinkers of several successive generations, including Laplace, Kelvin, Maxwell and Feynman. Le Sage's theory therefore provides an excellent opportunity for the study of the evolution of attitudes toward physical explanation. The effects of national style in science and generational change take on a new clarity.

  16. A Haptic Guided Robotic System for Endoscope Positioning and Holding.

    Science.gov (United States)

    Cabuk, Burak; Ceylan, Savas; Anik, Ihsan; Tugasaygi, Mehtap; Kizir, Selcuk

    2015-01-01

    To determine the feasibility, advantages, and disadvantages of using a robot for holding and maneuvering the endoscope in transnasal transsphenoidal surgery. The system used in this study was a Stewart Platform based robotic system that was developed by Kocaeli University Department of Mechatronics Engineering for positioning and holding of endoscope. After the first use on an artificial head model, the system was used on six fresh postmortem bodies that were provided by the Morgue Specialization Department of the Forensic Medicine Institute (Istanbul, Turkey). The setup required for robotic system was easy, the time for registration procedure and setup of the robot takes 15 minutes. The resistance was felt on haptic arm in case of contact or friction with adjacent tissues. The adaptation process was shorter with the mouse to manipulate the endoscope. The endoscopic transsphenoidal approach was achieved with the robotic system. The endoscope was guided to the sphenoid ostium with the help of the robotic arm. This robotic system can be used in endoscopic transsphenoidal surgery as an endoscope positioner and holder. The robot is able to change the position easily with the help of an assistant and prevents tremor, and provides a better field of vision for work.

  17. Contacts in the Office of Pesticide Programs, Registration Division

    Science.gov (United States)

    The Registration Division (RD) is responsible product registrations, amendments, registrations, tolerances, experimental use permits, and emergency exemptions for conventional chemical pesticides. Find contacts in this division.

  18. What drives Users' Website Registration?

    NARCIS (Netherlands)

    T. Li (Ting); P.A. Pavlou (Paul)

    2013-01-01

    textabstractUser registration is an important prerequisite for the success of many websites by enabling users to gain access to domain information and personalized content. It is not always desirable for users, however, because they need to disclose personal information. This paper examines what

  19. ACIR: automatic cochlea image registration

    Science.gov (United States)

    Al-Dhamari, Ibraheem; Bauer, Sabine; Paulus, Dietrich; Lissek, Friedrich; Jacob, Roland

    2017-02-01

    Efficient Cochlear Implant (CI) surgery requires prior knowledge of the cochlea's size and its characteristics. This information helps to select suitable implants for different patients. To get these measurements, a segmentation method of cochlea medical images is needed. An important pre-processing step for good cochlea segmentation involves efficient image registration. The cochlea's small size and complex structure, in addition to the different resolutions and head positions during imaging, reveals a big challenge for the automated registration of the different image modalities. In this paper, an Automatic Cochlea Image Registration (ACIR) method for multi- modal human cochlea images is proposed. This method is based on using small areas that have clear structures from both input images instead of registering the complete image. It uses the Adaptive Stochastic Gradient Descent Optimizer (ASGD) and Mattes's Mutual Information metric (MMI) to estimate 3D rigid transform parameters. The use of state of the art medical image registration optimizers published over the last two years are studied and compared quantitatively using the standard Dice Similarity Coefficient (DSC). ACIR requires only 4.86 seconds on average to align cochlea images automatically and to put all the modalities in the same spatial locations without human interference. The source code is based on the tool elastix and is provided for free as a 3D Slicer plugin. Another contribution of this work is a proposed public cochlea standard dataset which can be downloaded for free from a public XNAT server.

  20. Excess cash holdings and shareholder value

    OpenAIRE

    Lee, Edward; Powell, Ronan

    2011-01-01

    We examine the determinants of corporate cash holdings in Australia and the impact on shareholder wealth of holding excess cash. Our results show that a trade-off model best explains the level of a firm’s cash holdings in Australia. We find that 'transitory' excess cash firms earn significantly higher risk-adjusted returns compared to 'persistent' excess cash firms, suggesting that the market penalises firms that hoard cash. The marginal value of cash also declines with larger cash balances, ...

  1. Efficient nonrigid registration using ranked order statistics

    DEFF Research Database (Denmark)

    Tennakoon, Ruwan B.; Bab-Hadiashar, Alireza; de Bruijne, Marleen

    2013-01-01

    of research. In this paper we propose a fast and accurate non-rigid registration method for intra-modality volumetric images. Our approach exploits the information provided by an order statistics based segmentation method, to find the important regions for registration and use an appropriate sampling scheme......Non-rigid image registration techniques are widely used in medical imaging applications. Due to high computational complexities of these techniques, finding appropriate registration method to both reduce the computation burden and increase the registration accuracy has become an intense area...... to target those areas and reduce the registration computation time. A unique advantage of the proposed method is its ability to identify the point of diminishing returns and stop the registration process. Our experiments on registration of real lung CT images, with expert annotated landmarks, show...

  2. Evaluation of the use of registration stickers.

    Science.gov (United States)

    2011-04-01

    This research evaluated the potential costs and benefits of doing away with license plate registration stickers as part : of the registration renewal process for Pennsylvania. The research consisted of a comprehensive literature review, a : survey of...

  3. Fuels Registration, Reporting, and Compliance Help

    Science.gov (United States)

    Information about the requirements for registration and health effects testing of new fuels or fuel additives and mandatory registration for fuels reporting and about mandatory reporting forms for parties regulated under EPA fuel programs.

  4. Clinical trial registration in oral health journals.

    Science.gov (United States)

    Smaïl-Faugeron, V; Fron-Chabouis, H; Durieux, P

    2015-03-01

    Prospective registration of randomized controlled trials (RCTs) represents the best solution to reporting bias. The extent to which oral health journals have endorsed and complied with RCT registration is unknown. We identified journals publishing RCTs in dentistry, oral surgery, and medicine in the Journal Citation Reports. We classified journals into 3 groups: journals requiring or recommending trial registration, journals referring indirectly to registration, and journals providing no reference to registration. For the 5 journals with the highest 2012 impact factors in each group, we assessed whether RCTs with results published in 2013 had been registered. Of 78 journals examined, 32 (41%) required or recommended trial registration, 19 (24%) referred indirectly to registration, and 27 (35%) provided no reference to registration. We identified 317 RCTs with results published in the 15 selected journals in 2013. Overall, 73 (23%) were registered in a trial registry. Among those, 91% were registered retrospectively and 32% did not report trial registration in the published article. The proportion of trials registered was not significantly associated with editorial policies: 29% with results in journals that required or recommended registration, 15% in those that referred indirectly to registration, and 21% in those providing no reference to registration (P = 0.05). Less than one-quarter of RCTs with results published in a sample of oral health journals were registered with a public registry. Improvements are needed with respect to how journals inform and require their authors to register their trials. © International & American Associations for Dental Research.

  5. Solid Mesh Registration for Radiotherapy Treatment Planning

    DEFF Research Database (Denmark)

    Noe, Karsten Østergaard; Sørensen, Thomas Sangild

    2010-01-01

    We present an algorithm for solid organ registration of pre-segmented data represented as tetrahedral meshes. Registration of the organ surface is driven by force terms based on a distance field representation of the source and reference shapes. Registration of internal morphology is achieved usi...

  6. 32 CFR 634.19 - Registration policy.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Registration policy. 634.19 Section 634.19 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Motor Vehicle Registration § 634.19 Registration policy. (a) Motor vehicles will be...

  7. 21 CFR 710.8 - Misbranding by reference to registration or to registration number.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY REGISTRATION OF COSMETIC PRODUCT ESTABLISHMENTS § 710.8 Misbranding by reference to registration or to registration number. Registration of a cosmetic product... products by the Food and Drug Administration. Any representation in labeling or advertising that creates an...

  8. 21 CFR 710.6 - Notification of registrant; cosmetic product establishment registration number.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Notification of registrant; cosmetic product... OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY REGISTRATION OF COSMETIC PRODUCT ESTABLISHMENTS § 710.6 Notification of registrant; cosmetic product establishment registration number. The...

  9. 21 CFR 1301.52 - Termination of registration; transfer of registration; distribution upon discontinuance of business.

    Science.gov (United States)

    2010-04-01

    ... discontinues business or professional practice. Any registrant who ceases legal existence or discontinues... registration; distribution upon discontinuance of business. 1301.52 Section 1301.52 Food and Drugs DRUG... of registration; transfer of registration; distribution upon discontinuance of business. (a) Except...

  10. 75 FR 59803 - Endangered and Threatened Wildlife and Plants; Determination for the Gunnison Sage-grouse as a...

    Science.gov (United States)

    2010-09-28

    ... sage-grouse do not possess muscular gizzards and, therefore, lack the ability to grind and digest seeds...-grouse exhibit a polygamous mating system where a male mates with several females. Males perform...

  11. How Important Is a Reproducible Breath Hold for Deep Inspiration Breath Hold Breast Radiation Therapy?

    International Nuclear Information System (INIS)

    Wiant, David; Wentworth, Stacy; Liu, Han; Sintay, Benjamin

    2015-01-01

    Purpose: Deep inspiration breath hold (DIBH) for left-sided breast cancer has been shown to reduce heart dose. Surface imaging helps to ensure accurate breast positioning, but it does not guarantee a reproducible breath hold (BH) at DIBH treatments. We examine the effects of variable BH positions for DIBH treatments. Methods and Materials: Twenty-five patients who underwent free breathing (FB) and DIBH scans were reviewed. Four plans were created for each patient: FB, DIBH, FB-DIBH (the DIBH plans were copied to the FB images and recalculated, and image registration was based on breast tissue), and P-DIBH (a partial BH with the heart shifted midway between the FB and DIBH positions). The FB-DIBH plans give a “worst-case” scenario for surface imaging DIBH, where the breast is aligned by surface imaging but the patient is not holding their breath. Kolmogorov-Smirnov tests were used to compare the dose metrics. Results: The DIBH plans gave lower heart dose and comparable breast coverage versus FB in all cases. The FB-DIBH plans showed no significant difference versus FB plans for breast coverage, mean heart dose, or maximum heart dose (P≥.10). The mean heart dose differed between FB-DIBH and FB by <2 Gy for all cases, and the maximum heart dose differed by <2 Gy for 21 cases. The P-DIBH plans showed significantly lower mean heart dose than FB (P<.01). The mean heart doses for the P-DIBH plans were < FB for 22 cases, the maximum dose was < FB for 18 cases. Conclusions: A DIBH plan delivered to a FB patient setup with surface imaging will yield dosimetry similar to that of a plan created and delivered FB. A DIBH plan delivered with even a partial BH can give reduced heart dose compared with FB techniques.

  12. How Important Is a Reproducible Breath Hold for Deep Inspiration Breath Hold Breast Radiation Therapy?

    Energy Technology Data Exchange (ETDEWEB)

    Wiant, David, E-mail: David.wiant@conehealth.com; Wentworth, Stacy; Liu, Han; Sintay, Benjamin

    2015-11-15

    Purpose: Deep inspiration breath hold (DIBH) for left-sided breast cancer has been shown to reduce heart dose. Surface imaging helps to ensure accurate breast positioning, but it does not guarantee a reproducible breath hold (BH) at DIBH treatments. We examine the effects of variable BH positions for DIBH treatments. Methods and Materials: Twenty-five patients who underwent free breathing (FB) and DIBH scans were reviewed. Four plans were created for each patient: FB, DIBH, FB-DIBH (the DIBH plans were copied to the FB images and recalculated, and image registration was based on breast tissue), and P-DIBH (a partial BH with the heart shifted midway between the FB and DIBH positions). The FB-DIBH plans give a “worst-case” scenario for surface imaging DIBH, where the breast is aligned by surface imaging but the patient is not holding their breath. Kolmogorov-Smirnov tests were used to compare the dose metrics. Results: The DIBH plans gave lower heart dose and comparable breast coverage versus FB in all cases. The FB-DIBH plans showed no significant difference versus FB plans for breast coverage, mean heart dose, or maximum heart dose (P≥.10). The mean heart dose differed between FB-DIBH and FB by <2 Gy for all cases, and the maximum heart dose differed by <2 Gy for 21 cases. The P-DIBH plans showed significantly lower mean heart dose than FB (P<.01). The mean heart doses for the P-DIBH plans were

  13. Deodorant effects of a sage extract stick: Antibacterial activity and sensory evaluation of axillary deodorancy.

    Science.gov (United States)

    Shahtalebi, Mohammad Ali; Ghanadian, Mustafa; Farzan, Ali; Shiri, Niloufar; Shokri, Dariush; Fatemi, Syed Ali

    2013-10-01

    Deodorant products prevent the growth and activity of the degrading apocrine gland bacteria living in the armpit. Common antibacterial agents in the market like triclosan and aluminum salts, in spite of their suitable antibacterial effects, increase the risk of Alzheimer's disease, breast and prostate cancers or induce contact dermatitis. Therefore, plant extracts possessing antibacterial effects are of interest. The aim of the present study was to verify the in vitro antimicrobial effects of different sage extracts against two major bacteria responsible for axillary odor, and to evaluate the deodorant effect of a silicon-based stick containing sage extracts in different densities in humans. Different fractions of methanolic extract of Salvia officinalis (sage) were evaluated on a culture of armpit skin surface of volunteers through agar microdilution antimicrobial assay. Then, randomized, double-blind placebo-controlled clinical trial with the best antibacterial fraction was conducted on 45 female healthy volunteers. Participants were treated with a single dose in four groups, each containing 15 individuals: Group 1 (200 μg/mL), 2 (400 μg/mL), 3 (600 μg/mL) of dichloromethane sage extract, and placebo (without extract). A standard sensory evaluation method for the evaluation of deodorant efficacy was used before, and two hours, four hours, and eight hours after single application of a deodorant or placebo (ASTM method E 1207-87 Standard Practice for the Sensory Evaluation of Axillary Deodorancy). The data were analyzed with two factors relating to densities and time. In 45 participants with a mean [± standard deviation (SD)] age of 61.5±11.8 years, statistically significant within-group differences were observed before and two, four, and eight hours after deodorant treatment for groups 1, 2, and 3. Groups 1, 2, and 3 had a significantly smaller odor score than placebo after two, four, and eight hours (P sage extract sticks (P sage extract of 200, 400, or 600

  14. Unexpected observations after mapping LongSAGE tags to the human genome

    Directory of Open Access Journals (Sweden)

    Duret Laurent

    2007-05-01

    Full Text Available Abstract Background SAGE has been used widely to study the expression of known transcripts, but much less to annotate new transcribed regions. LongSAGE produces tags that are sufficiently long to be reliably mapped to a whole-genome sequence. Here we used this property to study the position of human LongSAGE tags obtained from all public libraries. We focused mainly on tags that do not map to known transcripts. Results Using a published error rate in SAGE libraries, we first removed the tags likely to result from sequencing errors. We then observed that an unexpectedly large number of the remaining tags still did not match the genome sequence. Some of these correspond to parts of human mRNAs, such as polyA tails, junctions between two exons and polymorphic regions of transcripts. Another non-negligible proportion can be attributed to contamination by murine transcripts and to residual sequencing errors. After filtering out our data with these screens to ensure that our dataset is highly reliable, we studied the tags that map once to the genome. 31% of these tags correspond to unannotated transcripts. The others map to known transcribed regions, but many of them (nearly half are located either in antisense or in new variants of these known transcripts. Conclusion We performed a comprehensive study of all publicly available human LongSAGE tags, and carefully verified the reliability of these data. We found the potential origin of many tags that did not match the human genome sequence. The properties of the remaining tags imply that the level of sequencing error may have been under-estimated. The frequency of tags matching once the genome sequence but not in an annotated exon suggests that the human transcriptome is much more complex than shown by the current human genome annotations, with many new splicing variants and antisense transcripts. SAGE data is appropriate to map new transcripts to the genome, as demonstrated by the high rate of cross

  15. Deodorant effects of a sage extract stick: Antibacterial activity and sensory evaluation of axillary deodorancy

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Shahtalebi

    2013-01-01

    Full Text Available Background: Deodorant products prevent the growth and activity of the degrading apocrine gland bacteria living in the armpit. Common antibacterial agents in the market like triclosan and aluminum salts, in spite of their suitable antibacterial effects, increase the risk of Alzheimer′s disease, breast and prostate cancers or induce contact dermatitis. Therefore, plant extracts possessing antibacterial effects are of interest. The aim of the present study was to verify the in vitro antimicrobial effects of different sage extracts against two major bacteria responsible for axillary odor, and to evaluate the deodorant effect of a silicon-based stick containing sage extracts in different densities in humans. Materials and Methods: Different fractions of methanolic extract of Salvia officinalis (sage were evaluated on a culture of armpit skin surface of volunteers through agar microdilution antimicrobial assay. Then, randomized, double-blind placebo-controlled clinical trial with the best antibacterial fraction was conducted on 45 female healthy volunteers. Participants were treated with a single dose in four groups, each containing 15 individuals: Group 1 (200 μg/mL, 2 (400 μg/mL, 3 (600 μg/mL of dichloromethane sage extract, and placebo (without extract. A standard sensory evaluation method for the evaluation of deodorant efficacy was used before, and two hours, four hours, and eight hours after single application of a deodorant or placebo (ASTM method E 1207-87 Standard Practice for the Sensory Evaluation of Axillary Deodorancy. Results: The data were analyzed with two factors relating to densities and time. In 45 participants with a mean [± standard deviation (SD] age of 61.5±11.8 years, statistically significant within-group differences were observed before and two, four, and eight hours after deodorant treatment for groups 1, 2, and 3. Groups 1, 2, and 3 had a significantly smaller odor score than placebo after two, four, and eight hours

  16. Inflation, operating cycle, and cash holdings

    Directory of Open Access Journals (Sweden)

    Yanchao Wang

    2014-12-01

    Full Text Available A corporate cash-holding strategy is a trade-off between the costs and benefits of holding cash. At the macrolevel, firms are inclined to adjust and optimize their cash-holding strategies in response to changes in purchasing power due to inflation. At the microlevel, the operating cycle, which indicates the speed and turnover of corporate cash flow, also influences the corporate cash-holding strategy. Firms flexibly adjust their cash-holding strategies in response to changes in the internal and external environment, which is referred to as the cash adjustment strategy. We examine these predicted relationships using a sample of listed firms in China’s stock market over the 1998–2009 period. Consistent with our predictions, the empirical results indicate a significant negative association between cash holdings and the CPI, but the relationship is reversed when the CPI reaches a certain level. There is also a U-shaped relationship between operating cycle and cash holdings, and this relationship is similarly influenced by changes in the inflation level. In examining the macroeconomic environment and microlevel firm-specific characteristics simultaneously, our findings supplement the literature on firms’ cash-holding strategies and provide theoretical and practical implications.

  17. Summer Camp July 2017 - Registration

    CERN Multimedia

    EVE et École

    2017-01-01

    The CERN Staff Association’s Summer Camp will be open for children from 4 to 6 years old during four weeks, from 3 to 28 July. Registration is offered on a weekly basis for 450 CHF, lunch included. This year, the various activities will revolve around the theme of the Four Elements. Registration opened on 20 March 2017 for children currently attending the EVE and School of the Association. It will be open from 3 April for children of CERN Members of Personnel, and starting from 24 April for all other children. The general conditions are available on the website of the EVE and School of CERN Staff Association: http://nurseryschool.web.cern.ch. For further questions, please contact us by email at Summer.Camp@cern.ch.

  18. Diffusion Maps for Multimodal Registration

    Directory of Open Access Journals (Sweden)

    Gemma Piella

    2014-06-01

    Full Text Available Multimodal image registration is a difficult task, due to the significant intensity variations between the images. A common approach is to use sophisticated similarity measures, such as mutual information, that are robust to those intensity variations. However, these similarity measures are computationally expensive and, moreover, often fail to capture the geometry and the associated dynamics linked with the images. Another approach is the transformation of the images into a common space where modalities can be directly compared. Within this approach, we propose to register multimodal images by using diffusion maps to describe the geometric and spectral properties of the data. Through diffusion maps, the multimodal data is transformed into a new set of canonical coordinates that reflect its geometry uniformly across modalities, so that meaningful correspondences can be established between them. Images in this new representation can then be registered using a simple Euclidean distance as a similarity measure. Registration accuracy was evaluated on both real and simulated brain images with known ground-truth for both rigid and non-rigid registration. Results showed that the proposed approach achieved higher accuracy than the conventional approach using mutual information.

  19. High-sensitive spectrometer of fast neutrons and the results of fast neutron background flux measurements at the gallium-germanium solar neutrino experiment (SAGE)

    International Nuclear Information System (INIS)

    Abdurashitov, D.N.; Gavrin, V.N.; Kalikhov, A.V.; Matushko, V.L.; Shikhin, A.A.; Yants, V.E.; Zaborskaya, O.S.

    2001-01-01

    The principle of operation, design, registration system and main characteristics of a fast neutron spectrometer are described. The spectrometer is intended for direct measurements of ultra-low fluxes of fast neutrons. It is sensitive to neutron fluxes of 10 -7 cm -2 · s -1 and lower. The detection efficiency of fast neutrons with simultaneous energy measurement was determined from Monte-Carlo simulation to be equal to 0.11 ± 0.01. The background counting rate in the detector corresponds to a neutron flux of (6.5 ± 2.1) · 10 -7 cm -2 · s -1 in the range of 1.0-11.0 MeV. The natural neutron flux from the surrounding mine rock at the depth of 4600 meters of water equivalent was measured to be (7.3 ± 2.4) · 10 -7 cm -2 · s -1 in the interval 1.0 -11.0 MeV. The flux of fast neutrons in the SAGE main room was measured to be 2.3 · 10 -7 cm -2 · s -1 in 1.0 - 11.0 MeV energy range

  20. Victoria's review of registration for health practitioners.

    Science.gov (United States)

    Scotts, H; Carter, M

    1988-01-01

    This article discusses some of the issues raised in the Interim Report of the current Review of Registration of Health Practitioners being conducted for the Victorian Health Department. The Report attempts to develop the framework in which the registration Boards will operate as part of a cohesive registration system. It proposed a mechanism and criteria for the registration of new groups as well as principles which can be applied to the ongoing review of each existing Board. The Review takes the perspective that registration of health practitioners carries with it both advantages and disadvantages for the general community. Under the proposed new system the controls exercised over health care providers by Registration Boards would be evaluated on the basis of to what extent the benefits to the public outweighed the potential costs. It is in this context that the Report addresses issues such as consumer complaints handling, registration of individual practitioners and controls over professional advertising and other business practices.

  1. Identification of irradiated sage tea (Salvia officinalis L.) by ESR spectroscopy

    International Nuclear Information System (INIS)

    Tepe Cam, Semra; Engin, Birol

    2010-01-01

    The use of electron spin resonance (ESR) spectroscopy to accurately distinguish irradiated from unirradiated sage tea was examined. Before irradiation, sage tea samples exhibit one asymmetric singlet ESR signal centered at g=2.0037. Besides this central signal, two weak satellite signals situated about 3 mT left and right to it in radiation-induced spectra. Irradiation with increasing doses caused a significant increase in radiation-induced ESR signal intensity at g=2.0265 (the left satellite signal) and this increase was found to be explained by a polynomial varying function. The stability of that radiation-induced ESR signal at room temperature was studied over a storage period of 9 months. Also, the kinetic of signal at g=2.0265 was studied in detail over a temperature range 313-353 K by annealing samples at different temperatures for various times.

  2. Opportunities of Gallium Sage experiment with artificial neutrino sources for investigation of neutrino to sterile states

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Gorbachiev, V.V.; Veretenkin, E.P.

    2011-01-01

    The unexpectedly low capture rate of neutrino in Ga source experiments in SAGE and GALLEX can be explained assuming electron neutrino transitions to sterile states with a mass-squared difference ∼ 1eV 2 . To test this oscillation hypothesis, we propose to place a very intense 51 Cr source at the center of a 50 tonne target of gallium metal that is divided into two zones and to measure the neutrino capture rate in each zone. The Experiment has the potential to test neutrino oscillation transitions with mass-squared difference Δm 2 > 0.5 eV 2 . An optimized SAGE setup and 3 MCi source of 51 Cr would provide a sensitivity to electron neutrino disappearance of a few percent.

  3. Identification of irradiated sage tea (Salvia officinalis L.) by ESR spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Tepe Cam, Semra, E-mail: stepe06@gmail.co [Gazi University, Faculty of Medicine, Biophysics Department, 06500 Besevler, Ankara (Turkey); Engin, Birol [Turkish Atomic Energy Authority, Saraykoey Nuclear Research and Training Center, 06983 Ankara (Turkey)

    2010-04-15

    The use of electron spin resonance (ESR) spectroscopy to accurately distinguish irradiated from unirradiated sage tea was examined. Before irradiation, sage tea samples exhibit one asymmetric singlet ESR signal centered at g=2.0037. Besides this central signal, two weak satellite signals situated about 3 mT left and right to it in radiation-induced spectra. Irradiation with increasing doses caused a significant increase in radiation-induced ESR signal intensity at g=2.0265 (the left satellite signal) and this increase was found to be explained by a polynomial varying function. The stability of that radiation-induced ESR signal at room temperature was studied over a storage period of 9 months. Also, the kinetic of signal at g=2.0265 was studied in detail over a temperature range 313-353 K by annealing samples at different temperatures for various times.

  4. Rate of germanium-isotope production by background processes in the SAGE experiment

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Gorbachev, V.V.; Ibragimova, T.V.; Cleveland, B.T.

    2002-01-01

    Data on a direct determination of systematic uncertainties caused by the background production of germanium isotopes in the radiochemical SAGE experiment measuring the solar-neutrino flux are analyzed. The result obtained for the rate of 68 Ge production is 6.5(1±1.0) times greater than the expected one; the rate of 69 Ge production does not exceed preliminary estimates. The above result for 68 Ge corresponds to the systematic uncertainty that is caused by the interaction of cosmic-ray muons and which is equal to 5.8% (4.5 SNU) at a solar-neutrino-capture rate of 77.0 SNU. An experiment is proposed that would test the effect of cosmic-ray muon influence on the SAGE systematic uncertainty and which would be performed at the location of the underground scintillation telescope facilities of the Baksan Neutrino Observatory (Institute for Nuclear Research, Russian Academy of Sciences)

  5. The germanium isotopes production rate in background process in SAGE experiment

    International Nuclear Information System (INIS)

    Gavrin, V.N.; Gorbachev, V.V.; Ibragimova, T.V.; Cleveland, B.T.

    2002-01-01

    The analysis of the direct determination of systematics connected with the germanium isotopes generation of in background processes in radiochemical SAGE experiments on measuring solar neutrinos is described. The found 68 Ge generation rate is 6.5 (1 ± 1.0) times higher than expected; the generation rate of 69 Ge does not exceed preliminary evaluations. The result on 68 Ge corresponds to the systematic of cosmic ray muons of 5.8% (4.5 SNU) for the measured capture rate of solar neutrino of 77.0 SNU. To check the cosmic-ray muon influence of the SAGE systematic one suggests the experiment in place of underground scintillation telescope of the Baksan neutrino observatory on the Institute for Nuclear Research of the RAS [ru

  6. Connaissance des pharmaciens d'officine à propos du droit de prescription des sages-femmes

    OpenAIRE

    Gache, Brune

    2012-01-01

    Introduction : La profession de sage-femme est une profession médicale à compétences définies. L'une d'entre elles nous intéresse particulièrement : le droit de prescription. Nous avons voulu évaluer les connaissances des pharmaciens d'officine, principaux intéressés de la mise en application de cette compétence. Matériel et méthode : L'objectif de ce travail de recherche était d'évaluer les connaissances des pharmaciens d'officine à propos du droit de prescription des sages-femmes ainsi que ...

  7. 78 FR 33419 - Announcement of Requirements and Registration for “Blue Button Co-Design Challenge”

    Science.gov (United States)

    2013-06-04

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of Requirements and Registration for ``Blue Button Co-Design Challenge'' AGENCY: Office of the National Coordinator for Health Information Technology... Electronic Health Record into another product or holding place of their choice. This is an enormous...

  8. Collective behaviors of book holding durations

    Science.gov (United States)

    Li, Ren-De; Guo, Qiang; Han, Jing-Ti; Liu, Jian-Guo

    2016-10-01

    Duration can directly reflect the collective reading behaviors of library user book holding. In this paper, by introducing the burstiness and memory coefficients, we empirically investigate the collective book holding behavior of three university libraries. The statistical results show that there are similar properties among the students with different backgrounds, presenting the burstiness = - 0.2 and memory = 0.5 for three datasets, which indicates that memory and random effects coexist in student book holding durations. In addition, we analyze the behavior patterns without duplicate durations by merging a series of books borrowed and returned at the same time. The results show the average burstiness B increases to -0.16 and memory M drops to 0.16 for three datasets, which indicates that both duplicate behavior and student's preference affect the memory effect. Furthermore, we present a model which assumes student's next book holding duration follows the previous one with probability p, and with probability 1 - p, the student would hold the book independently. The experimental results show that the presented model can reproduce the burstiness and memory effect of student book holding durations when p = 0.5 for empirical datasets and p = 0.2 for de-duplicate datasets, which indicate that the student's preferential holding behavior occurs with the probability p. This work helps in deeply understanding the regularity of duration-based human behaviors.

  9. Uptake and kinetics of 226Ra, 210Pb and 210Po in big sage brush

    International Nuclear Information System (INIS)

    Simon, S.L.

    1985-01-01

    Root uptake of 226 Pb and 210 Po by mature sage brush was studied using a soil injection method for spiking the soil with minimal root disturbance. The main objective was to measure vegetation concentrations and determine concentration ratios (CR's) due to root uptake as a function of time in mature big sage brush. Concentration ratios obtained in mature vegetation and in steady-state situations may be valuable in assessing the impact of uranium mining and milling. The vegetation was sampled approximately every 3 mo for A 2 y period. Significant levels of activity were detected in the vegetation beginning at the first sampling (81 d after soil injection for 226 Ra, 28 d for 210 Pb and 210 Po). There was an exponential decrease in concentration to an apparent steady state value. Mean values (geometric) of the data pooled over the second year period indicated that steady-state Cr's for 226 Ra, 210 Pb and 210 Po, as determined in mature sage brush, were 0.04, 0.009, and 0.08, respectively. Investigations were also carried out to verify the suitability of soil injection for uptake studies and to evaluate the time dependence of 226 Ra leaching from sage brush leaves. The soil injection method was determined to produce, on the average, uptake equivalent to that produce by a uniform soil distribution, however, the variety of uptake for plants growing in injected soil was higher than for plants growing in uniformly contaminated soil. A three compartment mathematical model was formulated to help understand mechanisms of plant uptake and to predict, if possible, the concentration of 226 Ra, 210 Po in vegetation as a function of time after soil spiking

  10. Linking occurrence and fitness to persistence: Habitat-based approach for endangered Greater Sage-Grouse

    Science.gov (United States)

    Aldridge, Cameron L.; Boyce, Mark S.

    2007-01-01

    Detailed empirical models predicting both species occurrence and fitness across a landscape are necessary to understand processes related to population persistence. Failure to consider both occurrence and fitness may result in incorrect assessments of habitat importance leading to inappropriate management strategies. We took a two-stage approach to identifying critical nesting and brood-rearing habitat for the endangered Greater Sage-Grouse (Centrocercus urophasianus) in Alberta at a landscape scale. First, we used logistic regression to develop spatial models predicting the relative probability of use (occurrence) for Sage-Grouse nests and broods. Secondly, we used Cox proportional hazards survival models to identify the most risky habitats across the landscape. We combined these two approaches to identify Sage-Grouse habitats that pose minimal risk of failure (source habitats) and attractive sink habitats that pose increased risk (ecological traps). Our models showed that Sage-Grouse select for heterogeneous patches of moderate sagebrush cover (quadratic relationship) and avoid anthropogenic edge habitat for nesting. Nests were more successful in heterogeneous habitats, but nest success was independent of anthropogenic features. Similarly, broods selected heterogeneous high-productivity habitats with sagebrush while avoiding human developments, cultivated cropland, and high densities of oil wells. Chick mortalities tended to occur in proximity to oil and gas developments and along riparian habitats. For nests and broods, respectively, approximately 10% and 5% of the study area was considered source habitat, whereas 19% and 15% of habitat was attractive sink habitat. Limited source habitats appear to be the main reason for poor nest success (39%) and low chick survival (12%). Our habitat models identify areas of protection priority and areas that require immediate management attention to enhance recruitment to secure the viability of this population. This novel

  11. Stratospheric aerosol effects from Soufriere Volcano as measured by the SAGE satellite system

    Science.gov (United States)

    Mccormick, M. P.; Kent, G. S.; Yue, G. K.; Cunnold, D. M.

    1982-01-01

    During its April 1979 eruption series, Soufriere Volcano produced two major stratospheric plumes that the SAGE (Stratospheric Aerosol and Gas Experiment) satellite system tracked to West Africa and the North Atlantic Ocean. The total mass of these plumes, whose movement and dispersion are in agreement with those deduced from meteorological data and dispersion theory, was less than 0.5 percent of the global stratospheric aerosol burden; no significant temperature or climate perturbation is therefore expected.

  12. SAGES Foregut Surgery Masters Program: a surgeon's social media resource for collaboration, education, and professional development.

    Science.gov (United States)

    Jackson, Hope T; Young, Monica T; Rodriguez, H Alejandro; Wright, Andrew S

    2018-06-01

    Facebook is a popular online social networking platform increasingly used for professional collaboration. Literature regarding use of Facebook for surgeon professional development and education is limited. The Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) has established a Facebook group dedicated to discussion of surgery of the esophagus, stomach, and small intestine-the "SAGES Foregut Surgery Masters Program." The aim of this study is to examine how this forum is used for professional development, education, and quality improvement. Member and post statistics were obtained from https://grytics.com , a Facebook group analytics service. All posts added to the Foregut forum since its creation in April 2015 through December 2016 were reviewed and categorized for content and topic. Posts were reviewed for potential identifiable protected health information. As of December 2016, there were 649 total members in the group. There have been a total of 411 posts and 4116 comments with a median of 10.1 comments/post (range 0-72). Posts were categorized as operative technique (64%), patient management (52%), continuing education (10%), networking (10%), or other (6%). Video and/or photos were included in 53% of posts with 4% of posts depicting radiologic studies and 13% with intraoperative photos or videos. An additional 40 posts included links to other pages, such as YouTube, journal articles, or the SAGES website. One post (0.2%) contained identifiable protected health information and was deleted once recognized by the moderators of the group. Social media is a unique, real-time platform where surgeons can learn, discuss, and collaborate towards the goal of optimal treatment of surgical disease. Active online surgical communities such as the SAGES Foregut Surgery Masters Program have the potential to enhance communication between surgeons and are a potential innovative adjunct to traditional methods of continuing surgical education. Surgical societies

  13. Successes and Challenges in the SAGE (Summer of Applied Geophysical Experience) REU Program

    Science.gov (United States)

    Braile, L. W.; Baldridge, W. S.; Pellerin, L.; Ferguson, J. F.; Bedrosian, P.; Biehler, S.; Jiracek, G. R.; Snelson, C. M.; Kelley, S.; McPhee, D.

    2014-12-01

    The SAGE program was initiated in 1983 to provide an applied geophysics research and education experience for students. Since 1983, 820 students have completed the SAGE summer program. Beginning in 1992, with funding from the NSF, SAGE has included an REU (Research Experience for Undergraduates) experience for selected undergraduate students from U.S. colleges and universities. Since 1992, 380 undergraduate REU students have completed the SAGE program. The four week, intensive, summer program is based in Santa Fe, New Mexico, and involves students in learning geophysical theory and applications; collection of geophysical field data in the northern Rio Grande Rift area; data processing, modeling and interpretation; and presentation (oral and written) of results of each student's research results. Students (undergraduates, graduates and professionals) and faculty are together on a school campus for the summer program. Successful strategies (developed over the years) of the program include teamwork experience, mentoring of REUs (by faculty and more senior students), cultural interchange due to students from many campuses across the U.S. and international graduate students, including industry visitors who work with the students and provide networking, a capstone experience of the summer program that includes all students making a "professional-meeting" style presentation of their research and submitting a written report, a follow-up workshop for the REU students to enhance and broaden their experience, and providing professional development for the REUs through oral or poster presentations and attendance at a professional meeting. Program challenges include obtaining funding from multiple sources; significant time investment in program management, reporting, and maintaining contact with our many funding sources and industry affiliates; and, despite significant efforts, limited success in recruiting racial and ethnic minority students to the program.

  14. Utilisation du partographe modifie de l'oms par les sages-femmes ...

    African Journals Online (AJOL)

    ) de l'OMS par les sages-femmes de Lomé et leur position face à cet outil de surveillance du travail. Matériel et méthode : Il s'agit d'une étude prospective, transversale descriptive, menée du 01er juillet au 30 septembre 2011 (soit une période ...

  15. Probability of lek collapse is lower inside sage-grouse Core Areas: Effectiveness of conservation policy for a landscape species.

    Directory of Open Access Journals (Sweden)

    Emma Suzuki Spence

    Full Text Available Greater sage-grouse (Centrocercus urophasianus occupy sagebrush (Artemisia spp. habitats in 11 western states and 2 Canadian provinces. In September 2015, the U.S. Fish and Wildlife Service announced the listing status for sage-grouse had changed from warranted but precluded to not warranted. The primary reason cited for this change of status was that the enactment of new regulatory mechanisms was sufficient to protect sage-grouse populations. One such plan is the 2008, Wyoming Sage Grouse Executive Order (SGEO, enacted by Governor Freudenthal. The SGEO identifies "Core Areas" that are to be protected by keeping them relatively free from further energy development and limiting other forms of anthropogenic disturbances near active sage-grouse leks. Using the Wyoming Game and Fish Department's sage-grouse lek count database and the Wyoming Oil and Gas Conservation Commission database of oil and gas well locations, we investigated the effectiveness of Wyoming's Core Areas, specifically: 1 how well Core Areas encompass the distribution of sage-grouse in Wyoming, 2 whether Core Area leks have a reduced probability of lek collapse, and 3 what, if any, edge effects intensification of oil and gas development adjacent to Core Areas may be having on Core Area populations. Core Areas contained 77% of male sage-grouse attending leks and 64% of active leks. Using Bayesian binomial probability analysis, we found an average 10.9% probability of lek collapse in Core Areas and an average 20.4% probability of lek collapse outside Core Areas. Using linear regression, we found development density outside Core Areas was related to the probability of lek collapse inside Core Areas. Specifically, probability of collapse among leks >4.83 km from inside Core Area boundaries was significantly related to well density within 1.61 km (1-mi and 4.83 km (3-mi outside of Core Area boundaries. Collectively, these data suggest that the Wyoming Core Area Strategy has benefited

  16. Probability of lek collapse is lower inside sage-grouse Core Areas: Effectiveness of conservation policy for a landscape species.

    Science.gov (United States)

    Spence, Emma Suzuki; Beck, Jeffrey L; Gregory, Andrew J

    2017-01-01

    Greater sage-grouse (Centrocercus urophasianus) occupy sagebrush (Artemisia spp.) habitats in 11 western states and 2 Canadian provinces. In September 2015, the U.S. Fish and Wildlife Service announced the listing status for sage-grouse had changed from warranted but precluded to not warranted. The primary reason cited for this change of status was that the enactment of new regulatory mechanisms was sufficient to protect sage-grouse populations. One such plan is the 2008, Wyoming Sage Grouse Executive Order (SGEO), enacted by Governor Freudenthal. The SGEO identifies "Core Areas" that are to be protected by keeping them relatively free from further energy development and limiting other forms of anthropogenic disturbances near active sage-grouse leks. Using the Wyoming Game and Fish Department's sage-grouse lek count database and the Wyoming Oil and Gas Conservation Commission database of oil and gas well locations, we investigated the effectiveness of Wyoming's Core Areas, specifically: 1) how well Core Areas encompass the distribution of sage-grouse in Wyoming, 2) whether Core Area leks have a reduced probability of lek collapse, and 3) what, if any, edge effects intensification of oil and gas development adjacent to Core Areas may be having on Core Area populations. Core Areas contained 77% of male sage-grouse attending leks and 64% of active leks. Using Bayesian binomial probability analysis, we found an average 10.9% probability of lek collapse in Core Areas and an average 20.4% probability of lek collapse outside Core Areas. Using linear regression, we found development density outside Core Areas was related to the probability of lek collapse inside Core Areas. Specifically, probability of collapse among leks >4.83 km from inside Core Area boundaries was significantly related to well density within 1.61 km (1-mi) and 4.83 km (3-mi) outside of Core Area boundaries. Collectively, these data suggest that the Wyoming Core Area Strategy has benefited sage

  17. Effect of zinc gluconate, sage oil on inflammatory patterns and hyperglycemia in zinc deficient diabetic rats.

    Science.gov (United States)

    Elseweidy, Mohamed M; Ali, Abdel-Moniem A; Elabidine, Nabila Zein; Mursey, Nada M

    2017-11-01

    The relationship between zinc homeostasis and pancreatic function had been established. In this study we aimed firstly to configure the inflammatory pattern and hyperglycemia in zinc deficient diabetic rats. Secondly to illustrate the effect of two selected agents namely Zinc gluconate and sage oil (Salvia Officinalis, family Lamiaceae). Rats were fed on Zinc deficient diet, deionized water for 28days along with Zinc level check up at intervals to achieve zinc deficient state then rats were rendered diabetic through receiving one dose of alloxan monohydrate (120mg/kg) body weight, classified later into 5 subgroups. Treatment with sage oil (0.042mg/kg IP) and Zinc gluconate orally (150mg/kg) body weight daily for 8 weeks significantly reduced serum glucose, C-reactive protein (CRP), Tumor necrosis factor alpha (TNF- α), interleukins-6 1 β, inflammatory8 (IFN ȣ), pancreatic 1L1-β along with an increase in serum Zinc and pancreatic Zinc transporter 8 (ZNT8). Histopathological results of pancreatic tissues showed a good correlation with the biochemical findings. Both sage oil and zinc gluconate induced an improvement in the glycemic and inflammatory states. This may be of value like the therapeutic agent for diabetes. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  18. Characterisation of a SAGe well detector using GEANT4 and LabSOCS

    Energy Technology Data Exchange (ETDEWEB)

    Britton, R., E-mail: rich.britton@awe.co.uk [AWE, Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom); University of Surrey, Guildford GU2 7XH (United Kingdom); Davies, A.V. [AWE, Aldermaston, Reading, Berkshire RG7 4PR (United Kingdom)

    2015-06-21

    This paper reports on the performance of a recently developed Small Anode Germanium (SAGe) well detector from Canberra Industries. This has been specifically designed to improve the energy resolution of the detector, such that it is comparable to the performance of broad-energy designs while achieving far higher efficiencies. Accurate efficiency characterisations and cascade summing correction factors are crucial for quantifying the radionuclides present in environmental samples, and these were calculated for the complex geometry posed by the well detector using two different methodologies. The first relied on Monte-Carlo simulations based upon the GEANT4 toolkit, and the second utilised Canberra Industries GENIE™ 2000 Gamma Analysis software in conjunction with a LabSOCS™ characterisation. Both were found to be in excellent agreement for all nuclides except for {sup 152}Eu, which presents a known issue in the Canberra software (all nuclides affected by this issue were well documented, and fixes are being developed). The correction factors were used to analyse two fully characterised reference samples, yielding results in good agreement with the accepted activity concentrations. Given the sensitivity of well type geometries to cascade summing, this represents a considerable achievement, and paves the way for the use of the SAGe well detector in analysis of ‘real-world’ environmental samples. With the efficiency increase when using the SAGe well in place of a BEGe, substantial reductions in the Minimum Detectable Activity (MDA) should be achievable for a range of nuclides.

  19. Reevaluation of Stratospheric Ozone Trends From SAGE II Data Using a Simultaneous Temporal and Spatial Analysis

    Science.gov (United States)

    Damadeo, R. P.; Zawodny, J. M.; Thomason, L. W.

    2014-01-01

    This paper details a new method of regression for sparsely sampled data sets for use with time-series analysis, in particular the Stratospheric Aerosol and Gas Experiment (SAGE) II ozone data set. Non-uniform spatial, temporal, and diurnal sampling present in the data set result in biased values for the long-term trend if not accounted for. This new method is performed close to the native resolution of measurements and is a simultaneous temporal and spatial analysis that accounts for potential diurnal ozone variation. Results show biases, introduced by the way data is prepared for use with traditional methods, can be as high as 10%. Derived long-term changes show declines in ozone similar to other studies but very different trends in the presumed recovery period, with differences up to 2% per decade. The regression model allows for a variable turnaround time and reveals a hemispheric asymmetry in derived trends in the middle to upper stratosphere. Similar methodology is also applied to SAGE II aerosol optical depth data to create a new volcanic proxy that covers the SAGE II mission period. Ultimately this technique may be extensible towards the inclusion of multiple data sets without the need for homogenization.

  20. SEMI-ANALYTIC GALAXY EVOLUTION (SAGE): MODEL CALIBRATION AND BASIC RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Croton, Darren J.; Stevens, Adam R. H.; Tonini, Chiara; Garel, Thibault; Bernyk, Maksym; Bibiano, Antonio; Hodkinson, Luke; Mutch, Simon J.; Poole, Gregory B.; Shattow, Genevieve M. [Centre for Astrophysics and Supercomputing, Swinburne University of Technology, P.O. Box 218, Hawthorn, Victoria 3122 (Australia)

    2016-02-15

    This paper describes a new publicly available codebase for modeling galaxy formation in a cosmological context, the “Semi-Analytic Galaxy Evolution” model, or sage for short.{sup 5} sage is a significant update to the 2006 model of Croton et al. and has been rebuilt to be modular and customizable. The model will run on any N-body simulation whose trees are organized in a supported format and contain a minimum set of basic halo properties. In this work, we present the baryonic prescriptions implemented in sage to describe the formation and evolution of galaxies, and their calibration for three N-body simulations: Millennium, Bolshoi, and GiggleZ. Updated physics include the following: gas accretion, ejection due to feedback, and reincorporation via the galactic fountain; a new gas cooling–radio mode active galactic nucleus (AGN) heating cycle; AGN feedback in the quasar mode; a new treatment of gas in satellite galaxies; and galaxy mergers, disruption, and the build-up of intra-cluster stars. Throughout, we show the results of a common default parameterization on each simulation, with a focus on the local galaxy population.

  1. Relationship between collapse history and ore distribution in Sage Breccia pipe, northwestern Arizona

    International Nuclear Information System (INIS)

    Brown, N.A.; Mead, R.H.; McMurray, J.M.

    1989-01-01

    The Sage pipe is similar to other collapse breccia pipes in northern Arizona which have their beginnings in cave systems in the Redwall Limestone. Stoping of successively younger units caused the upward propagation of the pipe and provided the pipe-filling breccia. The Sage pipe extends at least 2,500 ft (762 m) vertically; the horizontal dimensions range from 100 to 300 ft (30.5-91 m), depending on variations in the adjoining host stratigraphy. The composition and distribution of breccia facies suggest a complex collapse history and variability in the mechanics of collapse. Rock failure took place both by block stoping and by decementation of sandstone and siltstone followed by flow of unconsolidated grains. The resulting breccias range from matrix to fragment-dominated, to sand flow breccia resulting from flow of individual grains. Episodic secondary collapse or readjustment within the breccia pile complicated facies distribution. Paragenetic studies indicate multiple periods of mineralization at Sage resulting in enrichment in an extensive suite of elements. Ore-grade uranium mineralization extends vertically for nearly 700 ft (213 m). Lateral distribution of the ore is variable and is directly related to breccia facies distribution. In generally, the more permeable breccias tend to be the most highly mineralized. Fracture, intergranular, and interfragment permeability were important to mineral distribution. Breccia continuity or plumbing was also important to lateral and vertical mineral distribution

  2. SAGES TAVAC safety and effectiveness analysis: da Vinci ® Surgical System (Intuitive Surgical, Sunnyvale, CA).

    Science.gov (United States)

    Tsuda, Shawn; Oleynikov, Dmitry; Gould, Jon; Azagury, Dan; Sandler, Bryan; Hutter, Matthew; Ross, Sharona; Haas, Eric; Brody, Fred; Satava, Richard

    2015-10-01

    The da Vinci(®) Surgical System (Intuitive Surgical, Sunnyvale, CA, USA) is a computer-assisted (robotic) surgical system designed to enable and enhance minimally invasive surgery. The Food and Drug Administration (FDA) has cleared computer-assisted surgical systems for use by trained physicians in an operating room environment for laparoscopic surgical procedures in general, cardiac, colorectal, gynecologic, head and neck, thoracic and urologic surgical procedures. There are substantial numbers of peer-reviewed papers regarding the da Vinci(®) Surgical System, and a thoughtful assessment of evidence framed by clinical opinion is warranted. The SAGES da Vinci(®) TAVAC sub-committee performed a literature review of the da Vinci(®) Surgical System regarding gastrointestinal surgery. Conclusions by the sub-committee were vetted by the SAGES TAVAC Committee and SAGES Executive Board. Following revisions, the document was evaluated by the TAVAC Committee and Executive Board again for final approval. Several conclusions were drawn based on expert opinion organized by safety, efficacy, and cost for robotic foregut, bariatric, hepatobiliary/pancreatic, colorectal surgery, and single-incision cholecystectomy. Gastrointestinal surgery with the da Vinci(®) Surgical System is safe and comparable, but not superior to standard laparoscopic approaches. Although clinically acceptable, its use may be costly for select gastrointestinal procedures. Current data are limited to the da Vinci(®) Surgical System; further analyses are needed.

  3. SEMI-ANALYTIC GALAXY EVOLUTION (SAGE): MODEL CALIBRATION AND BASIC RESULTS

    International Nuclear Information System (INIS)

    Croton, Darren J.; Stevens, Adam R. H.; Tonini, Chiara; Garel, Thibault; Bernyk, Maksym; Bibiano, Antonio; Hodkinson, Luke; Mutch, Simon J.; Poole, Gregory B.; Shattow, Genevieve M.

    2016-01-01

    This paper describes a new publicly available codebase for modeling galaxy formation in a cosmological context, the “Semi-Analytic Galaxy Evolution” model, or sage for short. 5 sage is a significant update to the 2006 model of Croton et al. and has been rebuilt to be modular and customizable. The model will run on any N-body simulation whose trees are organized in a supported format and contain a minimum set of basic halo properties. In this work, we present the baryonic prescriptions implemented in sage to describe the formation and evolution of galaxies, and their calibration for three N-body simulations: Millennium, Bolshoi, and GiggleZ. Updated physics include the following: gas accretion, ejection due to feedback, and reincorporation via the galactic fountain; a new gas cooling–radio mode active galactic nucleus (AGN) heating cycle; AGN feedback in the quasar mode; a new treatment of gas in satellite galaxies; and galaxy mergers, disruption, and the build-up of intra-cluster stars. Throughout, we show the results of a common default parameterization on each simulation, with a focus on the local galaxy population

  4. Characterisation of a SAGe well detector using GEANT4 and LabSOCS

    International Nuclear Information System (INIS)

    Britton, R.; Davies, A.V.

    2015-01-01

    This paper reports on the performance of a recently developed Small Anode Germanium (SAGe) well detector from Canberra Industries. This has been specifically designed to improve the energy resolution of the detector, such that it is comparable to the performance of broad-energy designs while achieving far higher efficiencies. Accurate efficiency characterisations and cascade summing correction factors are crucial for quantifying the radionuclides present in environmental samples, and these were calculated for the complex geometry posed by the well detector using two different methodologies. The first relied on Monte-Carlo simulations based upon the GEANT4 toolkit, and the second utilised Canberra Industries GENIE™ 2000 Gamma Analysis software in conjunction with a LabSOCS™ characterisation. Both were found to be in excellent agreement for all nuclides except for 152 Eu, which presents a known issue in the Canberra software (all nuclides affected by this issue were well documented, and fixes are being developed). The correction factors were used to analyse two fully characterised reference samples, yielding results in good agreement with the accepted activity concentrations. Given the sensitivity of well type geometries to cascade summing, this represents a considerable achievement, and paves the way for the use of the SAGe well detector in analysis of ‘real-world’ environmental samples. With the efficiency increase when using the SAGe well in place of a BEGe, substantial reductions in the Minimum Detectable Activity (MDA) should be achievable for a range of nuclides

  5. Supercritical carbon dioxide extraction of antioxidants from rosemary (Rosmarinus officinalis L. and sage (Salvia officinalis L.

    Directory of Open Access Journals (Sweden)

    JASNA IVANOVIĆ

    2009-07-01

    Full Text Available The aim of the present study was to isolate and characterize antioxidant extracts obtained from dried leaves of rosemary (Rosmarinus officinalis L. and sage (Salvia officinalis L., originating from the southern Balkan Region. The antioxidant fraction was isolated from the plant material by supercritical carbon dioxide (SC-CO2 fractional extraction under a pressure of 30 MPa and at temperatures of 40 and 100 °C. In the present study, kinetic data and yields of antioxidant extracts obtained from dried leaves of rosemary and sage under different conditions were determined. Electron spin resonance (ESR spectroscopy assay on the ability of the extracts to scavenge stable 2,2-diphenyl-1-picrylhydrazyl (DPPH free radicals and reactive hydroxyl radicals during the Fenton reaction trapped by 5,5-dimethyl-1-pyrroline-N-oxide (DMPO showed that the investigated extracts had antioxidant activity comparable to that of butylated hydroxyanisole (BHA and commercial rosemary extract. The antioxidant fractions isolated at the higher temperature had higher antioxidant activities. A tentative analysis of the chemical composition of the antioxidant fractions obtained at the higher temperature was accomplished by LC-DAD and LC-MS analytical methods. Abietane-type diterpenoids, flavonoids and fatty acids were identified in the SC-CO2 extract of rosemary and sage.

  6. Data Resource Profile: Cross-national and cross-study sociodemographic and health-related harmonized domains from SAGE plus ELSA, HRS and SHARE (SAGE+, Wave 1).

    Science.gov (United States)

    Minicuci, Nadia; Naidoo, Nirmala; Chatterji, Somnath; Kowal, Paul

    2016-10-01

    Four longitudinal studies were included in this rigorous harmonization process: the Study on global AGEing and adult health (SAGE); English Longitudinal Study on Ageing (ELSA); US Health and Retirement Study (HRS); and Survey of Health, Ageing and Retirement in Europe (SHARE). An ex-post harmonized process was applied to nine health-related thematic domains (socio-demographic and economic, health states, overall self-report of health and mental state, health examinations, physical and mental performance tests, risk factors, chronic conditions, social network and subjective well-being) for data from the 2004 wave of each study. Large samples of adults aged 50 years and older were available from each study: SAGE, n = 18 886; ELSA, n = 9181; HRS, n = 19 303; and SHARE, n = 29 917. The microdata, along with further details about the harmonization process and all metadata, are available through the World Health Organization (WHO) data archive at [http://apps.who.int/healthinfo/systems/surveydata/index.php/catalog]. Further information and enquiries can be made to [sagesurvey@who.int] or the corresponding author. The data resource will continue to be updated with data across additional waves of these surveys and new waves. © The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

  7. Aerosol extinction profiles at 525 nm and 1020 nm derived from ACE imager data: comparisons with GOMOS, SAGE II, SAGE III, POAM III, and OSIRIS

    Directory of Open Access Journals (Sweden)

    F. Vanhellemont

    2008-04-01

    Full Text Available The Canadian ACE (Atmospheric Chemistry Experiment mission is dedicated to the retrieval of a large number of atmospheric trace gas species using the solar occultation technique in the infrared and UV/visible spectral domain. However, two additional solar disk imagers (at 525 nm and 1020 nm were added for a number of reasons, including the retrieval of aerosol and cloud products. In this paper, we present first comparison results for these imager aerosol/cloud optical extinction coefficient profiles, with the ones derived from measurements performed by 3 solar occultation instruments (SAGE II, SAGE III, POAM III, one stellar occultation instrument (GOMOS and one limb sounder (OSIRIS. The results indicate that the ACE imager profiles are of good quality in the upper troposphere/lower stratosphere, although the aerosol extinction for the visible channel at 525 nm contains a significant negative bias at higher altitudes, while the relative differences indicate that ACE profiles are almost always too high at 1020 nm. Both problems are probably related to ACE imager instrumental issues.

  8. Registration Day-Camp 2016

    CERN Multimedia

    Nursery School

    2016-01-01

    Reminder Registration for the CERN Staff Association Day-camp are open for children from 4 to 6 years old More information on the website: http://nurseryschool.web.cern.ch/. The day-camp is open to all children. An inscription per week is proposed, cost 480.-CHF/week, lunch included The camp will be open weeks 27, 28, 29 and 30, from 8:30 am to 5:30 pm. For further questions, thanks you for contacting us by email at Summer.Camp@cern.ch.

  9. Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.).

    Science.gov (United States)

    Walch, Stephan G; Kuballa, Thomas; Stühlinger, Wolf; Lachenmeier, Dirk W

    2011-07-21

    The sage plant Salvia officinalis L. is used as ingredient in foods and beverages as well as in herbal medicinal products. A major use is in the form of aqueous infusions as sage tea, which is legal to be sold as either food or medicine. Sage may contain two health relevant substances, thujone and camphor. The aim of this study was to develop and validate an analytical methodology to determine these active principles of sage and give a first overview of their concentrations in a wide variety of sage foods and medicines. A GC/MS procedure was applied for the analysis of α- and β-thujone and camphor with cyclodecanone as internal standard. The precision was between 0.8 and 12.6%, linearity was obtained from 0.1 - 80 mg/L. The recoveries of spiked samples were between 93.7 and 104.0% (average 99.1%). The time of infusion had a considerable influence on the content of analytes found in the teas. During the brewing time, thujone and camphor show an increase up to about 5 min, after which saturation is reached. No effect was found for preparation with or without a lid on the pot used for brewing the infusion. Compared to extracts with ethanol (60% vol), which provide a maximum yield, an average of 30% thujone are recovered in the aqueous tea preparations. The average thujone and camphor contents were 4.4 mg/L and 16.7 mg/L in food tea infusions and 11.3 mg/L and 25.4 mg/L in medicinal tea infusions. The developed methodology allows the efficient determination of thujone and camphor in a wide variety of sage food and medicine matrices and can be applied to conduct surveys for exposure assessment. The current results suggest that on average between 3 and 6 cups of sage tea could be daily consumed without reaching toxicological thresholds.

  10. Improving communication with palliative care cancer patients at home - A pilot study of SAGE & THYME communication skills model.

    Science.gov (United States)

    Griffiths, Jane; Wilson, Charlotte; Ewing, Gail; Connolly, Michael; Grande, Gunn

    2015-10-01

    To pilot an evidence-based communication skills model (SAGE & THYME) with UK District Nurses (DNs) who visit patients with advanced cancer early in the dying trajectory. Evidence suggests that DNs lack confidence in communication skills and in assessing cancer patients' psycho-social needs; also that they lack time. SAGE & THYME is a highly structured model for teaching patient centred interactions. It addresses concerns about confidence and time. Mixed methods. 33 DNs were trained in SAGE & THYME in a three hour workshop and interviewed in focus groups on three occasions: pre-training, immediately post-training and two months post-training. Questionnaires measuring perceived outcomes of communication, confidence in communication and motivation to use SAGE & THYME were administered at the focus groups. SAGE & THYME provided a structure for conversations and facilitated opening and closing of interactions. The main principle of patient centeredness was reportedly used by all. Knowledge about communication behaviours helpful to patients improved and was sustained two months after training. Increased confidence in communication skills was also sustained. Motivation to use SAGE & THYME was high and remained so at two months, and some said the model saved them time. Challenges with using the model included controlling the home environment and a change in style of communication which was so marked some DNs preferred to use it with new patients. Training DNs in SAGE & THYME in a three hour workshop appears to be a promising model for improving communication skills when working with cancer patients. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved.

  11. Daily nest survival rates of Gunnison Sage-Grouse (Centrocercus minimus): assessing local- and landscape-scale drivers

    Science.gov (United States)

    Stanley, Thomas R.; Aldridge, Cameron L.; Joanne Saher,; Theresa Childers,

    2015-01-01

    The Gunnison Sage-Grouse (Centrocercus minimus) is a species of conservation concern and is a candidate for listing under the U.S. Endangered Species Act because of substantial declines in populations from historic levels. It is thought that loss, fragmentation, and deterioration of sagebrush (Artemisia spp.) habitat have contributed to the decline and isolation of this species into seven geographically distinct subpopulations. Nest survival is known to be a primary driver of demography of Greater Sage-Grouse (C. urophasianus), but no unbiased estimates of daily nest survival rates (hereafter nest survival) exist for Gunnison Sage-Grouse or published studies identifying factors that influence nest survival. We estimated nest survival of Gunnison Sage-Grouse for the western portion of Colorado's Gunnison Basin subpopulation, and assessed the effects and relative importance of local- and landscape-scale habitat characteristics on nest survival. Our top performing model was one that allowed variation in nest survival among areas, suggesting a larger landscape-area effect. Overall nest success during a 38-day nesting period (egg-laying plus incubation) was 50% (daily survival rate; SE  =  0.982 [0.003]), which is higher than previous estimates for Gunnison Sage-Grouse and generally higher than published for the closely related Greater Sage-Grouse. We did not find strong evidence that local-scale habitat variables were better predictors of nest survival than landscape-scale predictors, nor did we find strong evidence that any of the habitat variables we measured were good predictors of nest survival. Nest success of Gunnison Sage-Grouse in the western portion of the Gunnison Basin was higher than previously believed.

  12. Decadal-Scale Responses in Middle and Upper Stratospheric Ozone From SAGE II Version 7 Data

    Science.gov (United States)

    Remsberg, E. E.

    2014-01-01

    Stratospheric Aerosol and Gas Experiment (SAGE II) version 7 (v7) ozone profiles are analyzed for their decadal-scale responses in the middle and upper stratosphere for 1991 and 1992-2005 and compared with those from its previous version 6.2 (v6.2). Multiple linear regression (MLR) analysis is applied to time series of its ozone number density vs. altitude data for a range of latitudes and altitudes. The MLR models that are fit to the time series data include a periodic 11 yr term, and it is in-phase with that of the 11 yr, solar UV (Ultraviolet)-flux throughout most of the latitude/ altitude domain of the middle and upper stratosphere. Several regions that have a response that is not quite in-phase are interpreted as being affected by decadal-scale, dynamical forcings. The maximum minus minimum, solar cycle (SClike) responses for the ozone at the low latitudes are similar from the two SAGE II data versions and vary from about 5 to 2.5% from 35 to 50 km, although they are resolved better with v7. SAGE II v7 ozone is also analyzed for 1984-1998, in order to mitigate effects of end-point anomalies that bias its ozone in 1991 and the analyzed results for 1991-2005 or following the Pinatubo eruption. Its SC-like ozone response in the upper stratosphere is of the order of 4%for 1984-1998 vs. 2.5 to 3%for 1991-2005. The SAGE II v7 results are also recompared with the responses in ozone from the Halogen Occultation Experiment (HALOE) that are in terms of mixing ratio vs. pressure for 1991-2005 and then for late 1992- 2005 to avoid any effects following Pinatubo. Shapes of their respective response profiles agree very well for 1992-2005. The associated linear trends of the ozone are not as negative in 1992-2005 as in 1984-1998, in accord with a leveling off of the effects of reactive chlorine on ozone. It is concluded that the SAGE II v7 ozone yields SC-like ozone responses and trends that are of better quality than those from v6.2.

  13. Characteristic Performance Evaluation of a new SAGe Well Detector for Small and Large Sample Geometries

    International Nuclear Information System (INIS)

    Adekola, A.S.; Colaresi, J.; Douwen, J.; Jaederstroem, H.; Mueller, W.F.; Yocum, K.M.; Carmichael, K.

    2015-01-01

    Environmental scientific research requires a detector that has sensitivity low enough to reveal the presence of any contaminant in the sample at a reasonable counting time. Canberra developed the germanium detector geometry called Small Anode Germanium (SAGe) Well detector, which is now available commercially. The SAGe Well detector is a new type of low capacitance germanium well detector manufactured using small anode technology capable of advancing many environmental scientific research applications. The performance of this detector has been evaluated for a range of sample sizes and geometries counted inside the well, and on the end cap of the detector. The detector has energy resolution performance similar to semi-planar detectors, and offers significant improvement over the existing coaxial and Well detectors. Energy resolution performance of 750 eV Full Width at Half Maximum (FWHM) at 122 keV γ-ray energy and resolution of 2.0 - 2.3 keV FWHM at 1332 keV γ-ray energy are guaranteed for detector volumes up to 425 cm 3 . The SAGe Well detector offers an optional 28 mm well diameter with the same energy resolution as the standard 16 mm well. Such outstanding resolution performance will benefit environmental applications in revealing the detailed radionuclide content of samples, particularly at low energy, and will enhance the detection sensitivity resulting in reduced counting time. The detector is compatible with electric coolers without any sacrifice in performance and supports the Canberra Mathematical efficiency calibration method (In situ Object Calibration Software or ISOCS, and Laboratory Source-less Calibration Software or LABSOCS). In addition, the SAGe Well detector supports true coincidence summing available in the ISOCS/LABSOCS framework. The improved resolution performance greatly enhances detection sensitivity of this new detector for a range of sample sizes and geometries counted inside the well. This results in lower minimum detectable

  14. Characteristic Performance Evaluation of a new SAGe Well Detector for Small and Large Sample Geometries

    Energy Technology Data Exchange (ETDEWEB)

    Adekola, A.S.; Colaresi, J.; Douwen, J.; Jaederstroem, H.; Mueller, W.F.; Yocum, K.M.; Carmichael, K. [Canberra Industries Inc., 800 Research Parkway, Meriden, CT 06450 (United States)

    2015-07-01

    Environmental scientific research requires a detector that has sensitivity low enough to reveal the presence of any contaminant in the sample at a reasonable counting time. Canberra developed the germanium detector geometry called Small Anode Germanium (SAGe) Well detector, which is now available commercially. The SAGe Well detector is a new type of low capacitance germanium well detector manufactured using small anode technology capable of advancing many environmental scientific research applications. The performance of this detector has been evaluated for a range of sample sizes and geometries counted inside the well, and on the end cap of the detector. The detector has energy resolution performance similar to semi-planar detectors, and offers significant improvement over the existing coaxial and Well detectors. Energy resolution performance of 750 eV Full Width at Half Maximum (FWHM) at 122 keV γ-ray energy and resolution of 2.0 - 2.3 keV FWHM at 1332 keV γ-ray energy are guaranteed for detector volumes up to 425 cm{sup 3}. The SAGe Well detector offers an optional 28 mm well diameter with the same energy resolution as the standard 16 mm well. Such outstanding resolution performance will benefit environmental applications in revealing the detailed radionuclide content of samples, particularly at low energy, and will enhance the detection sensitivity resulting in reduced counting time. The detector is compatible with electric coolers without any sacrifice in performance and supports the Canberra Mathematical efficiency calibration method (In situ Object Calibration Software or ISOCS, and Laboratory Source-less Calibration Software or LABSOCS). In addition, the SAGe Well detector supports true coincidence summing available in the ISOCS/LABSOCS framework. The improved resolution performance greatly enhances detection sensitivity of this new detector for a range of sample sizes and geometries counted inside the well. This results in lower minimum detectable

  15. The salt-responsive transcriptome of chickpea roots and nodules via deepSuperSAGE

    Directory of Open Access Journals (Sweden)

    Steinhauer Diana

    2011-02-01

    Full Text Available Abstract Background The combination of high-throughput transcript profiling and next-generation sequencing technologies is a prerequisite for genome-wide comprehensive transcriptome analysis. Our recent innovation of deepSuperSAGE is based on an advanced SuperSAGE protocol and its combination with massively parallel pyrosequencing on Roche's 454 sequencing platform. As a demonstration of the power of this combination, we have chosen the salt stress transcriptomes of roots and nodules of the third most important legume crop chickpea (Cicer arietinum L.. While our report is more technology-oriented, it nevertheless addresses a major world-wide problem for crops generally: high salinity. Together with low temperatures and water stress, high salinity is responsible for crop losses of millions of tons of various legume (and other crops. Continuously deteriorating environmental conditions will combine with salinity stress to further compromise crop yields. As a good example for such stress-exposed crop plants, we started to characterize salt stress responses of chickpeas on the transcriptome level. Results We used deepSuperSAGE to detect early global transcriptome changes in salt-stressed chickpea. The salt stress responses of 86,919 transcripts representing 17,918 unique 26 bp deepSuperSAGE tags (UniTags from roots of the salt-tolerant variety INRAT-93 two hours after treatment with 25 mM NaCl were characterized. Additionally, the expression of 57,281 transcripts representing 13,115 UniTags was monitored in nodules of the same plants. From a total of 144,200 analyzed 26 bp tags in roots and nodules together, 21,401 unique transcripts were identified. Of these, only 363 and 106 specific transcripts, respectively, were commonly up- or down-regulated (>3.0-fold under salt stress in both organs, witnessing a differential organ-specific response to stress. Profiting from recent pioneer works on massive cDNA sequencing in chickpea, more than 9,400 Uni

  16. The cadastral registration of the property right

    Directory of Open Access Journals (Sweden)

    D.-G. IONAȘ

    2017-12-01

    Full Text Available Real rights are subjective patrimonial rights which provide the holder with the right to directly exercise certain prerogatives over a determined good. Real rights over immobile goods, registered in the cadastral register are called tabular rights. Cadastral registration is that certain form of registration by which a real right over an immobile good is acquired, changed or ended, from the time de registration request is filed. At this time, registration in the cadastral register provides the opposability effect, as the constitutive effect is suspended until the cadastral works are finalized and new cadastral registers are created for each administrative unit.

  17. Earth Science With the Stratospheric Aerosol and Gas Experiment III (SAGE III) on the International Space Station

    Science.gov (United States)

    Zawodny, Joe; Vernier, Jean-Paul; Thomason, Larry; Roell, Marilee; Pitts, Mike; Moore, Randy; Hill, Charles; Flittner, David; Damadeo, Rob; Cisewski, Mike

    2015-01-01

    The Stratospheric Aerosol and Gas Experiment (SAGE) III is the fourth generation of solar occultation instruments operated by NASA, the first coming under a different acronym, to investigate the Earth's upper atmosphere. Three flight-ready SAGE III instruments were built by Ball Aerospace in the late 1990s, with one launched aboard the former Russian Aviation and Space Agency (now known as Roskosmos) Meteor-3M platform on 10 December 2001 (continuing until the platform lost power in 2006). Another of the original instruments was manifested for the ISS in the 2004 time frame, but was delayed because of budgetary considerations. Fortunately, that SAGE III/ISS mission was restarted in 2009 with a major focus upon filling an anticipated gap in ozone and aerosol observation in the second half of this decade. Here we discuss the mission architecture, its implementation, and data that will be produced by SAGE III/ISS, including their expected accuracy and coverage. The 52-degree inclined orbit of the ISS is well-suited for solar occultation and provides near-global observations on a monthly basis with excellent coverage of low and mid-latitudes. This is similar to that of the SAGE II mission (1985-2005), whose data set has served the international atmospheric science community as a standard for stratospheric ozone and aerosol measurements. The nominal science products include vertical profiles of trace gases, such as ozone, nitrogen dioxide and water vapor, along with multi-wavelength aerosol extinction. Though in the visible portion of the spectrum the brightness of the Sun is one million times that of the full Moon, the SAGE III instrument is designed to cover this large dynamic range and also perform lunar occultations on a routine basis to augment the solar products. The standard lunar products were demonstrated during the SAGE III/M3M mission and include ozone, nitrogen dioxide & nitrogen trioxide. The operational flexibility of the SAGE III spectrometer accomplishes

  18. Integrating spatially explicit indices of abundance and habitat quality: an applied example for greater sage-grouse management.

    Science.gov (United States)

    Coates, Peter S; Casazza, Michael L; Ricca, Mark A; Brussee, Brianne E; Blomberg, Erik J; Gustafson, K Benjamin; Overton, Cory T; Davis, Dawn M; Niell, Lara E; Espinosa, Shawn P; Gardner, Scott C; Delehanty, David J

    2016-02-01

    Predictive species distributional models are a cornerstone of wildlife conservation planning. Constructing such models requires robust underpinning science that integrates formerly disparate data types to achieve effective species management.Greater sage-grouse Centrocercus urophasianus , hereafter 'sage-grouse' populations are declining throughout sagebrush-steppe ecosystems in North America, particularly within the Great Basin, which heightens the need for novel management tools that maximize the use of available information.Herein, we improve upon existing species distribution models by combining information about sage-grouse habitat quality, distribution and abundance from multiple data sources. To measure habitat, we created spatially explicit maps depicting habitat selection indices (HSI) informed by >35 500 independent telemetry locations from >1600 sage-grouse collected over 15 years across much of the Great Basin. These indices were derived from models that accounted for selection at different spatial scales and seasons. A region-wide HSI was calculated using the HSI surfaces modelled for 12 independent subregions and then demarcated into distinct habitat quality classes.We also employed a novel index to describe landscape patterns of sage-grouse abundance and space use (AUI). The AUI is a probabilistic composite of the following: (i) breeding density patterns based on the spatial configuration of breeding leks and associated trends in male attendance; and (ii) year-round patterns of space use indexed by the decreasing probability of use with increasing distance to leks. The continuous AUI surface was then reclassified into two classes representing high and low/no use and abundance. Synthesis and application s. Using the example of sage-grouse, we demonstrate how the joint application of indices of habitat selection, abundance and space use derived from multiple data sources yields a composite map that can guide effective allocation of management

  19. Integrating spatially explicit indices of abundance and habitat quality: an applied example for greater sage-grouse management

    Science.gov (United States)

    Coates, Peter S.; Casazza, Michael L.; Ricca, Mark A.; Brussee, Brianne E.; Blomberg, Erik J.; Gustafson, K. Benjamin; Overton, Cory T.; Davis, Dawn M.; Niell, Lara E.; Espinosa, Shawn P.; Gardner, Scott C.; Delehanty, David J.

    2016-01-01

    Predictive species distributional models are a cornerstone of wildlife conservation planning. Constructing such models requires robust underpinning science that integrates formerly disparate data types to achieve effective species management. Greater sage-grouse Centrocercus urophasianus, hereafter “sage-grouse” populations are declining throughout sagebrush-steppe ecosystems in North America, particularly within the Great Basin, which heightens the need for novel management tools that maximize use of available information. Herein, we improve upon existing species distribution models by combining information about sage-grouse habitat quality, distribution, and abundance from multiple data sources. To measure habitat, we created spatially explicit maps depicting habitat selection indices (HSI) informed by > 35 500 independent telemetry locations from > 1600 sage-grouse collected over 15 years across much of the Great Basin. These indices were derived from models that accounted for selection at different spatial scales and seasons. A region-wide HSI was calculated using the HSI surfaces modelled for 12 independent subregions and then demarcated into distinct habitat quality classes. We also employed a novel index to describe landscape patterns of sage-grouse abundance and space use (AUI). The AUI is a probabilistic composite of: (i) breeding density patterns based on the spatial configuration of breeding leks and associated trends in male attendance; and (ii) year-round patterns of space use indexed by the decreasing probability of use with increasing distance to leks. The continuous AUI surface was then reclassified into two classes representing high and low/no use and abundance. Synthesis and applications. Using the example of sage-grouse, we demonstrate how the joint application of indices of habitat selection, abundance, and space use derived from multiple data sources yields a composite map that can guide effective allocation of management intensity across

  20. Development and Implementation of Efficiency-Improving Analysis Methods for the SAGE III on ISS Thermal Model Originating

    Science.gov (United States)

    Liles, Kaitlin; Amundsen, Ruth; Davis, Warren; Scola, Salvatore; Tobin, Steven; McLeod, Shawn; Mannu, Sergio; Guglielmo, Corrado; Moeller, Timothy

    2013-01-01

    The Stratospheric Aerosol and Gas Experiment III (SAGE III) instrument is the fifth in a series of instruments developed for monitoring aerosols and gaseous constituents in the stratosphere and troposphere. SAGE III will be delivered to the International Space Station (ISS) via the SpaceX Dragon vehicle in 2015. A detailed thermal model of the SAGE III payload has been developed in Thermal Desktop (TD). Several novel methods have been implemented to facilitate efficient payload-level thermal analysis, including the use of a design of experiments (DOE) methodology to determine the worst-case orbits for SAGE III while on ISS, use of TD assemblies to move payloads from the Dragon trunk to the Enhanced Operational Transfer Platform (EOTP) to its final home on the Expedite the Processing of Experiments to Space Station (ExPRESS) Logistics Carrier (ELC)-4, incorporation of older models in varying unit sets, ability to change units easily (including hardcoded logic blocks), case-based logic to facilitate activating heaters and active elements for varying scenarios within a single model, incorporation of several coordinate frames to easily map to structural models with differing geometries and locations, and streamlined results processing using an Excel-based text file plotter developed in-house at LaRC. This document presents an overview of the SAGE III thermal model and describes the development and implementation of these efficiency-improving analysis methods.

  1. Volatile Profile of Croatian Lime Tree (Tilia sp., Fir Honeydew (Abies alba and Sage (Salvia officinalis Honey

    Directory of Open Access Journals (Sweden)

    Olivera Koprivnjak

    2007-01-01

    Full Text Available Volatile profiles of lime tree (Tilia sp., fir honeydew (Abies alba and sage (Salvia officinalis honey produced in Croatia have been studied by using headspace solid phase microextraction (HS-SPME followed by gas chromatography-mass spectrometry (GC-MS analysis. Melissopalynological and sensory characterization have been performed in order to check the reliability of botanical origin of the samples. In case of sage honey, sensory characteristics are reported for the first time and are rather uniform including: colour characterized as beige to jade, depending on the consistency; odour characterized as between light and medium intensity, slightly pungent and wooden; taste characterized as low sweetness, expressive acidity and apple caramel, with persistent fruity aftertaste. Characteristic volatile profiles of the analyzed honeys are described. Taking into consideration similarities with lime and fir honey volatile profiles reported in literature, characteristic volatile compounds resulting from qualitative data evaluation are proposed. Sage honey volatile profile has been reported for the first time and it was found quite different compared to the other studied honeys showing the lowest number of peaks among the studied honeys, 34. Several compounds belonging to the sage honey volatile profile have been identified for the first time in honeys. They include tetrahydro-2,2,5,5-tetramethylfuran, 3-hexenyl ester of butanoic acid, 2-methylbenzene, maltol, methyl ester of 3-furanocarboxylic acid and benzeneacetic acid. Based on the obtained results and with the lack of comparative literature data, they are proposed as characteristic volatiles for the volatile pattern of sage honey.

  2. Self-administered Gerocognitive Examination (SAGE): a brief cognitive assessment Instrument for mild cognitive impairment (MCI) and early dementia.

    Science.gov (United States)

    Scharre, Douglas W; Chang, Shu-Ing; Murden, Robert A; Lamb, James; Beversdorf, David Q; Kataki, Maria; Nagaraja, Haikady N; Bornstein, Robert A

    2010-01-01

    To develop a self-administered cognitive assessment instrument to facilitate the screening of mild cognitive impairment (MCI) and early dementia and determine its association with gold standard clinical assessments including neuropsychologic evaluation. Adults aged above 59 years with sufficient vision and English literacy were recruited from geriatric and memory disorder clinics, educational talks, independent living facilities, senior centers, and memory screens. After Self-administered Gerocognitive Examination (SAGE) screening, subjects were randomly selected to complete a clinical evaluation, neurologic examination, neuropsychologic battery, functional assessment, and mini-mental state examination (MMSE). Subjects were identified as dementia, MCI, or normal based on standard clinical criteria and neuropsychologic testing. Two hundred fifty-four participants took the SAGE screen and 63 subjects completed the extensive evaluation (21 normal, 21 MCI, and 21 dementia subjects). Spearman rank correlation between SAGE and neuropsychologic battery was 0.84 (0.76 for MMSE). SAGE receiver operating characteristics on the basis of clinical diagnosis showed 95% specificity (90% for MMSE) and 79% sensitivity (71% for MMSE) in detecting those with cognitive impairment from normal subjects. This study suggests that SAGE is a reliable instrument for detecting cognitive impairment and compares favorably with the MMSE. The self-administered feature may promote cognitive testing by busy clinicians prompting earlier diagnosis and treatment.

  3. Performance evaluation of 2D image registration algorithms with the numeric image registration and comparison platform

    International Nuclear Information System (INIS)

    Gerganov, G.; Kuvandjiev, V.; Dimitrova, I.; Mitev, K.; Kawrakow, I.

    2012-01-01

    The objective of this work is to present the capabilities of the NUMERICS web platform for evaluation of the performance of image registration algorithms. The NUMERICS platform is a web accessible tool which provides access to dedicated numerical algorithms for registration and comparison of medical images (http://numerics.phys.uni-sofia.bg). The platform allows comparison of noisy medical images by means of different types of image comparison algorithms, which are based on statistical tests for outliers. The platform also allows 2D image registration with different techniques like Elastic Thin-Plate Spline registration, registration based on rigid transformations, affine transformations, as well as non-rigid image registration based on Mobius transformations. In this work we demonstrate how the platform can be used as a tool for evaluation of the quality of the image registration process. We demonstrate performance evaluation of a deformable image registration technique based on Mobius transformations. The transformations are applied with appropriate cost functions like: Mutual information, Correlation coefficient, Sum of Squared Differences. The accent is on the results provided by the platform to the user and their interpretation in the context of the performance evaluation of 2D image registration. The NUMERICS image registration and image comparison platform provides detailed statistical information about submitted image registration jobs and can be used to perform quantitative evaluation of the performance of different image registration techniques. (authors)

  4. 77 FR 66920 - Registration of Claims to Copyright: Group Registration of Serial Issues Filed Electronically

    Science.gov (United States)

    2012-11-08

    ... registered on a single application and for a single fee. The group registration privilege is contingent upon... was limited to basic registrations, i.e., claims in single works, while the capacity to process online... of related serials. Revisions to the electronic registration system will upgrade the capacity of the...

  5. Influence of heart rhythm, breathing and arm position during computed tomography scanning on the registration accuracy of electro anatomical map (EAM) images, left atrium three-dimensional computed tomography angiography images, and fluoroscopy time during ablation to treat atrial fibrillation

    International Nuclear Information System (INIS)

    Chono, Taiki; Shimoshige, Shinya; Yoshikawa, Kenta; Mizonobe, Kazuhusa; Ogura, Keishi

    2013-01-01

    In CARTOMERGE for treatment of atrial fibrillation (AF) by ablation, by integrating electro anatomical map (EAM) and left atrium three-dimensional computed tomography angiography (3D-CTA) images, identification of the ablation points is simplified and the procedure can be made carried out more rapidly. However, the influence that heart rhythm, breathing and arm position during CT scanning have on registration accuracy and fluoroscopy time is not clear. To clarify the influence on registration accuracy and fluoroscopy time of heart rhythm, breathing and arm position during CT scanning. The patients were CT-scanned during both sinus rhythm (SR) and AF in each study subject. We evaluated the registration accuracy of images reconstructed between the cardiac cycle and assessed the registration accuracy and fluoroscopy time of images obtained during inspiratory breath-hold, expiratory breath-hold and up and down position of the arm. Although the registration accuracy of the EAM image and left atrium 3D-CTA image showed a significant difference during SR, no significant difference was seen during AF. Expiratory breath-hold and down position of the arm resulted in the highest registration accuracy and the shortest fluoroscopy time. However, arm position had no significant effect on registration accuracy. Heart rhythm and breathing during CT scanning have a significant effect on the registration accuracy of EAM images, left atrium 3D-CTA images, and fluoroscopy time. (author)

  6. Central research registration at Technical University of Denmark (DTU)

    DEFF Research Database (Denmark)

    Sand, Ane Ahrenkiel

    Some five years ago, DTU switched from decentralized research registration, where researchers entered their publications into the DTU research repository themselves to centralized research registration, whereby library staff upload academic publications to the repository on behalf...... up the registration team, the configuration of the repository platform (Pure), the registration workflow and last but not least the results since DTU switched to centralized research registration....

  7. Central Research Registration at Technical University of Denmark (DTU)

    DEFF Research Database (Denmark)

    Sand, Ane Ahrenkiel

    Some five years ago, DTU switched from decentralized research registration, where researchers entered their publications into the DTU research repository themselves to centralized research registration, whereby library staff upload academic publications to the repository on behalf...... up the registration team, the configuration of the repository platform (Pure), the registration workflow and last but not least the results since DTU switched to centralized research registration....

  8. A combination of LongSAGE with Solexa sequencing is well suited to explore the depth and the complexity of transcriptome

    Directory of Open Access Journals (Sweden)

    Scoté-Blachon Céline

    2008-09-01

    Full Text Available Abstract Background "Open" transcriptome analysis methods allow to study gene expression without a priori knowledge of the transcript sequences. As of now, SAGE (Serial Analysis of Gene Expression, LongSAGE and MPSS (Massively Parallel Signature Sequencing are the mostly used methods for "open" transcriptome analysis. Both LongSAGE and MPSS rely on the isolation of 21 pb tag sequences from each transcript. In contrast to LongSAGE, the high throughput sequencing method used in MPSS enables the rapid sequencing of very large libraries containing several millions of tags, allowing deep transcriptome analysis. However, a bias in the complexity of the transcriptome representation obtained by MPSS was recently uncovered. Results In order to make a deep analysis of mouse hypothalamus transcriptome avoiding the limitation introduced by MPSS, we combined LongSAGE with the Solexa sequencing technology and obtained a library of more than 11 millions of tags. We then compared it to a LongSAGE library of mouse hypothalamus sequenced with the Sanger method. Conclusion We found that Solexa sequencing technology combined with LongSAGE is perfectly suited for deep transcriptome analysis. In contrast to MPSS, it gives a complex representation of transcriptome as reliable as a LongSAGE library sequenced by the Sanger method.

  9. Utilizing hunter harvest effort to survey for wildlife disease: a case study of West Nile virus in greater sage-grouse

    Science.gov (United States)

    Dusek, Robert J.; Hagen, Christian A.; Franson, J. Christian; Budeau, David A.; Hofmeister, Erik K.

    2014-01-01

    Greater sage-grouse (Centrocercus urophasianus; sage-grouse) are highly susceptible to infection with West Nile virus (WNV), with substantial mortality reported in wild populations and in experimentally infected birds. Although sage-grouse are hunted throughout much of their range, they have also recently been considered for protection under the Endangered Species Act. We used blood samples collected on filter-paper strips during the 2006–2010 Oregon, USA, annual sage-grouse hunt to survey for specific WNV-neutralizing antibodies that indicate a previous infection with WNV. During this period, hunters submitted 1,880 blood samples from sage-grouse they harvested. Samples obtained were proportional for all 12 Oregon sage-grouse hunting units. Laboratory testing of 1,839 samples by the WNV epitope-blocking enzyme-linked immunosorbent assay (bELISA) followed by plaque reduction neutralization test on bELISA-positive samples yielded 19 (1%) and 1 (0.05%) positive samples, respectively. These data provided early baseline information for future comparisons regarding the prevalence of WNV-specific neutralizing antibodies in sage-grouse in Oregon. This methodology may provide other states where sage-grouse (or other species) populations are hunted and where WNV constitutes a species conservation concern with a viable option to track the relative prevalence of the virus in populations.

  10. Image navigation and registration for the geostationary lightning mapper (GLM)

    Science.gov (United States)

    van Bezooijen, Roel W. H.; Demroff, Howard; Burton, Gregory; Chu, Donald; Yang, Shu S.

    2016-10-01

    The Geostationary Lightning Mappers (GLM) for the Geostationary Operational Environmental Satellite (GOES) GOES-R series will, for the first time, provide hemispherical lightning information 24 hours a day from longitudes of 75 and 137 degrees west. The first GLM of a series of four is planned for launch in November, 2016. Observation of lightning patterns by GLM holds promise to improve tornado warning lead times to greater than 20 minutes while halving the present false alarm rates. In addition, GLM will improve airline traffic flow management, and provide climatology data allowing us to understand the Earth's evolving climate. The paper describes the method used for translating the pixel position of a lightning event to its corresponding geodetic longitude and latitude, using the J2000 attitude of the GLM mount frame reported by the spacecraft, the position of the spacecraft, and the alignment of the GLM coordinate frame relative to its mount frame. Because the latter alignment will experience seasonal variation, this alignment is determined daily using GLM background images collected over the previous 7 days. The process involves identification of coastlines in the background images and determination of the alignment change necessary to match the detected coastline with the coastline predicted using the GSHHS database. Registration is achieved using a variation of the Lucas-Kanade algorithm where we added a dither and average technique to improve performance significantly. An innovative water mask technique was conceived to enable self-contained detection of clear coastline sections usable for registration. Extensive simulations using accurate visible images from GOES13 and GOES15 have been used to demonstrate the performance of the coastline registration method, the results of which are presented in the paper.

  11. Semiautomated Multimodal Breast Image Registration

    Directory of Open Access Journals (Sweden)

    Charlotte Curtis

    2012-01-01

    However, due to the highly deformable nature of breast tissues, comparison of 3D and 2D modalities is a challenge. To enable this comparison, a registration technique was developed to map features from 2D mammograms to locations in the 3D image space. This technique was developed and tested using magnetic resonance (MR images as a reference 3D modality, as MR breast imaging is an established technique in clinical practice. The algorithm was validated using a numerical phantom then successfully tested on twenty-four image pairs. Dice's coefficient was used to measure the external goodness of fit, resulting in an excellent overall average of 0.94. Internal agreement was evaluated by examining internal features in consultation with a radiologist, and subjective assessment concludes that reasonable alignment was achieved.

  12. Registration Day-Camp 2016

    CERN Multimedia

    Nursery School

    2016-01-01

    Registration for the CERN SA Day-camp are open for children from 4 to 6 years old From March 14 to 25 for children already enrolled in CERN SA EVE and School From April 4 to 15 for the children of CERN members of the personnel (MP) From April 18 for other children More information on the website: http://nurseryschool.web.cern.ch/. The day-camp is open to all children. An inscription per week is proposed, cost 480.-CHF/week, lunch included The camp will be open weeks 27, 28, 29 and 30, from 8:30 am to 5:30 pm. For further questions, thanks you for contacting us by email at Summer.Camp@cern.ch.

  13. Does imminent threat capture and hold attention?

    Science.gov (United States)

    Koster, Ernst H W; Crombez, Geert; Van Damme, Stefaan; Verschuere, Bruno; De Houwer, Jan

    2004-09-01

    According to models of attention and emotion, threat captures and holds attention. In behavioral tasks, robust evidence has been found for attentional holding but not for attentional capture by threat. An important explanation for the absence of attentional capture effects is that the visual stimuli used posed no genuine threat. The present study investigated whether visual cues that signal an aversive white noise can elicit attentional capture and holding effects. Cues presented in an attentional task were simultaneously provided with a threat value through an aversive conditioning procedure. Response latencies showed that threatening cues captured and held attention. These results support recent views on attention to threat, proposing that imminent threat captures attention in everyone. (c) 2004 APA, all rights reserved

  14. 49 CFR 107.503 - Registration statement.

    Science.gov (United States)

    2010-10-01

    ... tank motor vehicles which the registrant intends to manufacture, assemble, repair, inspect, test or... this section, each person who repairs a cargo tank or cargo tank motor vehicle must submit a copy of... PROGRAM PROCEDURES Registration of Cargo Tank and Cargo Tank Motor Vehicle Manufacturers, Assemblers...

  15. 76 FR 27898 - Registration and Recordation Program

    Science.gov (United States)

    2011-05-13

    ... to reflect a reorganization that has moved the Recordation function from the Visual Arts and... function from the Visual Arts and Recordation Division of the Registration and Recordation Program to the... Visual Arts Division of the Registration and Recordation Program, has been renamed the Recordation...

  16. 27 CFR 25.112 - Dealer registration.

    Science.gov (United States)

    2010-04-01

    .... Every brewer who sells, or offers for sale, any alcohol product (distilled spirits, wines, or beer) fit... registration. Registration covers all sales from the same location, including sales of wine, spirits, or other... for making sales of wine or beer at the customer's place of business. Otherwise, a brewer who conducts...

  17. Deformable image registration using convolutional neural networks

    NARCIS (Netherlands)

    Eppenhof, Koen A.J.; Lafarge, Maxime W.; Moeskops, Pim; Veta, Mitko; Pluim, Josien P.W.

    2018-01-01

    Deformable image registration can be time-consuming and often needs extensive parameterization to perform well on a specific application. We present a step towards a registration framework based on a three-dimensional convolutional neural network. The network directly learns transformations between

  18. Tenure Security Reformand Electronic Registration: Exploring ...

    African Journals Online (AJOL)

    This paper examines the potential significance of updating registration practices in resolving some of the issues about tenure security in a transformative context. It deals with the importance of good governance in the context of land administration and considers its impact on intended reforms. Land registration practice as an ...

  19. 40 CFR 68.160 - Registration.

    Science.gov (United States)

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.160 Registration. (a) The owner or operator shall... substances handled in covered processes. (b) The registration shall include the following data: (1...

  20. 32 CFR 636.9 - Registration requirement.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Registration requirement. 636.9 Section 636.9 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION (SPECIFIC INSTALLATIONS) Fort Stewart, Georgia § 636.9 Registration requirement. In...

  1. 32 CFR 636.8 - Registration policy.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Registration policy. 636.8 Section 636.8 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION (SPECIFIC INSTALLATIONS) Fort Stewart, Georgia § 636.8 Registration policy. In addition to th...

  2. Fast fluid registration of medical images

    DEFF Research Database (Denmark)

    Bro-Nielsen, Morten; Gramkow, Claus

    1996-01-01

    This paper offers a new fast algorithm for non-rigid viscous fluid registration of medical images that is at least an order of magnitude faster than the previous method by (Christensen et al., 1994). The core algorithm in the fluid registration method is based on a linear elastic deformation...

  3. 19 CFR 360.102 - Online registration.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Online registration. 360.102 Section 360.102... ANALYSIS SYSTEM § 360.102 Online registration. (a) In general. (1) Any importer, importing company, customs.... boxes will not be accepted. A user identification number will be issued within two business days...

  4. On combining algorithms for deformable image registration

    NARCIS (Netherlands)

    Muenzing, S.E.A.; Ginneken, van B.; Pluim, J.P.W.; Dawant, B.M.

    2012-01-01

    We propose a meta-algorithm for registration improvement by combining deformable image registrations (MetaReg). It is inspired by a well-established method from machine learning, the combination of classifiers. MetaReg consists of two main components: (1) A strategy for composing an improved

  5. Genomic single-nucleotide polymorphisms confirm that Gunnison and Greater sage-grouse are genetically well differentiated and that the Bi-State population is distinct

    Science.gov (United States)

    Oyler-McCance, Sara J.; Cornman, Robert S.; Jones, Kenneth L.; Fike, Jennifer

    2015-01-01

    Sage-grouse are iconic, declining inhabitants of sagebrush habitats in western North America, and their management depends on an understanding of genetic variation across the landscape. Two distinct species of sage-grouse have been recognized, Greater (Centrocercus urophasianus) and Gunnison sage-grouse (C. minimus), based on morphology, behavior, and variation at neutral genetic markers. A parapatric group of Greater Sage-Grouse along the border of California and Nevada ("Bi-State") is also genetically distinct at the same neutral genetic markers, yet not different in behavior or morphology. Because delineating taxonomic boundaries and defining conservation units is often difficult in recently diverged taxa and can be further complicated by highly skewed mating systems, we took advantage of new genomic methods that improve our ability to characterize genetic variation at a much finer resolution. We identified thousands of single-nucleotide polymorphisms (SNPs) among Gunnison, Greater, and Bi-State sage-grouse and used them to comprehensively examine levels of genetic diversity and differentiation among these groups. The pairwise multilocus fixation index (FST) was high (0.49) between Gunnison and Greater sage-grouse, and both principal coordinates analysis and model-based clustering grouped samples unequivocally by species. Standing genetic variation was lower within the Gunnison Sage-Grouse. The Bi-State population was also significantly differentiated from Greater Sage-Grouse, albeit more weakly (FST = 0.09), and genetic clustering results were consistent with reduced gene flow with Greater Sage-Grouse. No comparable genetic divisions were found within the Greater Sage-Grouse sample, which spanned the southern half of the range. Thus, we provide much stronger genetic evidence supporting the recognition of Gunnison Sage-Grouse as a distinct species with low genetic diversity. Further, our work confirms that the Bi-State population is differentiated from other

  6. 12 CFR Appendix E to Part 360 - Hold File Structure

    Science.gov (United States)

    2010-01-01

    ... ReasonReason for the hold. Possible values are: Character (2). • LN = Loan Collateral Hold • LG = Court... structure of the data file to provide information to the FDIC for each legal or collateral hold placed on a...

  7. Greater sage-grouse winter habitat use on the eastern edge of their range

    Science.gov (United States)

    Swanson, Christopher C.; Rumble, Mark A.; Grovenburg, Troy W.; Kaczor, Nicholas W.; Klaver, Robert W.; Herman-Brunson, Katie M.; Jenks, Jonathan A.; Jensen, Kent C.

    2013-01-01

    Greater sage-grouse (Centrocercus urophasianus) at the western edge of the Dakotas occur in the transition zone between sagebrush and grassland communities. These mixed sagebrush (Artemisia sp.) and grasslands differ from those habitats that comprise the central portions of the sage-grouse range; yet, no information is available on winter habitat selection within this region of their distribution. We evaluated factors influencing greater sage-grouse winter habitat use in North Dakota during 2005–2006 and 2006–2007 and in South Dakota during 2006–2007 and 2007–2008. We captured and radio-marked 97 breeding-age females and 54 breeding-age males from 2005 to 2007 and quantified habitat selection for 98 of these birds that were alive during winter. We collected habitat measurements at 340 (177 ND, 163 SD) sage-grouse use sites and 680 random (340 each at 250 m and 500 m from locations) dependent sites. Use sites differed from random sites with greater percent sagebrush cover (14.75% use vs. 7.29% random; P 2 use vs. 0.94 plants/m2 random; P ≤ 0.001), but lesser percent grass cover (11.76% use vs. 16.01% random; P ≤ 0.001) and litter cover (4.34% use vs. 5.55% random; P = 0.001) and lower sagebrush height (20.02 cm use vs. 21.35 cm random; P = 0.13) and grass height (21.47 cm use vs. 23.21 cm random; P = 0.15). We used conditional logistic regression to estimate winter habitat selection by sage-grouse on continuous scales. The model sagebrush cover + sagebrush height + sagebrush cover × sagebrush height (wi = 0.60) was the most supported of the 13 models we considered, indicating that percent sagebrush cover strongly influenced selection. Logistic odds ratios indicated that the probability of selection by sage-grouse increased by 1.867 for every 1% increase in sagebrush cover (95% CI = 1.627–2.141) and by 1.041 for every 1 cm increase in sagebrush height (95% CI = 1.002–1.082). The

  8. Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer

    DEFF Research Database (Denmark)

    Maheswaran, Emeaga; Pedersen, Christina B; Ditzel, Henrik J

    2015-01-01

    and antigenic properties, but the expression patterns of most of the more than 200 identified cancer/testis antigens in various cancers remain largely uncharacterized. In this study, we investigated the expression of the cancer/testis antigens ADAM2, CALR3 and SAGE1 in lung and breast cancer, the two most...... frequent human cancers, with the purpose of providing novel therapeutic targets for these diseases. We used a set of previously uncharacterized antibodies against the cancer/testis antigens ADAM2, CALR3 and SAGE1 to investigate their expression in a large panel of normal tissues as well as breast and lung...... cancers. Staining for the well-characterized MAGE-A proteins was included for comparison. Immunohistochemical staining confirmed previous mRNA analysis demonstrating that ADAM2, CALR3 and SAGE1 proteins are confined to testis in normal individuals. Negative tissues included plancenta, which express many...

  9. SAGES: a suite of freely-available software tools for electronic disease surveillance in resource-limited settings.

    Directory of Open Access Journals (Sweden)

    Sheri L Lewis

    Full Text Available Public health surveillance is undergoing a revolution driven by advances in the field of information technology. Many countries have experienced vast improvements in the collection, ingestion, analysis, visualization, and dissemination of public health data. Resource-limited countries have lagged behind due to challenges in information technology infrastructure, public health resources, and the costs of proprietary software. The Suite for Automated Global Electronic bioSurveillance (SAGES is a collection of modular, flexible, freely-available software tools for electronic disease surveillance in resource-limited settings. One or more SAGES tools may be used in concert with existing surveillance applications or the SAGES tools may be used en masse for an end-to-end biosurveillance capability. This flexibility allows for the development of an inexpensive, customized, and sustainable disease surveillance system. The ability to rapidly assess anomalous disease activity may lead to more efficient use of limited resources and better compliance with World Health Organization International Health Regulations.

  10. Cash Holdings and Mutual Fund Performance

    OpenAIRE

    Mikhail Simutin

    2014-01-01

    Cash holdings of equity mutual funds impose a drag on fund performance but also allow managers to make quick investments in attractive stocks and satisfy outflows without costly fire sales. This article shows that actively managed equity funds with high abnormal cash—that is, with cash holdings in excess of the level predicted by fund attributes—outperform their low abnormal cash peers by over 2% per year. Managers carrying high abnormal cash compensate for the low return on cash by making su...

  11. Medical Image Registration and Surgery Simulation

    DEFF Research Database (Denmark)

    Bro-Nielsen, Morten

    1996-01-01

    This thesis explores the application of physical models in medical image registration and surgery simulation. The continuum models of elasticity and viscous fluids are described in detail, and this knowledge is used as a basis for most of the methods described here. Real-time deformable models......, and the use of selective matrix vector multiplication. Fluid medical image registration A new and faster algorithm for non-rigid registration using viscous fluid models is presented. This algorithm replaces the core part of the original algorithm with multi-resolution convolution using a new filter, which...... growth is also presented. Using medical knowledge about the growth processes of the mandibular bone, a registration algorithm for time sequence images of the mandible is developed. Since this registration algorithm models the actual development of the mandible, it is possible to simulate the development...

  12. Large-scale control site selection for population monitoring: an example assessing Sage-grouse trends

    Science.gov (United States)

    Fedy, Bradley C.; O'Donnell, Michael; Bowen, Zachary H.

    2015-01-01

    Human impacts on wildlife populations are widespread and prolific and understanding wildlife responses to human impacts is a fundamental component of wildlife management. The first step to understanding wildlife responses is the documentation of changes in wildlife population parameters, such as population size. Meaningful assessment of population changes in potentially impacted sites requires the establishment of monitoring at similar, nonimpacted, control sites. However, it is often difficult to identify appropriate control sites in wildlife populations. We demonstrated use of Geographic Information System (GIS) data across large spatial scales to select biologically relevant control sites for population monitoring. Greater sage-grouse (Centrocercus urophasianus; hearafter, sage-grouse) are negatively affected by energy development, and monitoring of sage-grouse population within energy development areas is necessary to detect population-level responses. Weused population data (1995–2012) from an energy development area in Wyoming, USA, the Atlantic Rim Project Area (ARPA), and GIS data to identify control sites that were not impacted by energy development for population monitoring. Control sites were surrounded by similar habitat and were within similar climate areas to the ARPA. We developed nonlinear trend models for both the ARPA and control sites and compared long-term trends from the 2 areas. We found little difference between the ARPA and control sites trends over time. This research demonstrated an approach for control site selection across large landscapes and can be used as a template for similar impact-monitoring studies. It is important to note that identification of changes in population parameters between control and treatment sites is only the first step in understanding the mechanisms that underlie those changes. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

  13. Crucial nesting habitat for gunnison sage-grouse: A spatially explicit hierarchical approach

    Science.gov (United States)

    Aldridge, Cameron L.; Saher, D.J.; Childers, T.M.; Stahlnecker, K.E.; Bowen, Z.H.

    2012-01-01

    Gunnison sage-grouse (Centrocercus minimus) is a species of special concern and is currently considered a candidate species under Endangered Species Act. Careful management is therefore required to ensure that suitable habitat is maintained, particularly because much of the species' current distribution is faced with exurban development pressures. We assessed hierarchical nest site selection patterns of Gunnison sage-grouse inhabiting the western portion of the Gunnison Basin, Colorado, USA, at multiple spatial scales, using logistic regression-based resource selection functions. Models were selected using Akaike Information Criterion corrected for small sample sizes (AIC c) and predictive surfaces were generated using model averaged relative probabilities. Landscape-scale factors that had the most influence on nest site selection included the proportion of sagebrush cover >5%, mean productivity, and density of 2 wheel-drive roads. The landscape-scale predictive surface captured 97% of known Gunnison sage-grouse nests within the top 5 of 10 prediction bins, implicating 57% of the basin as crucial nesting habitat. Crucial habitat identified by the landscape model was used to define the extent for patch-scale modeling efforts. Patch-scale variables that had the greatest influence on nest site selection were the proportion of big sagebrush cover >10%, distance to residential development, distance to high volume paved roads, and mean productivity. This model accurately predicted independent nest locations. The unique hierarchical structure of our models more accurately captures the nested nature of habitat selection, and allowed for increased discrimination within larger landscapes of suitable habitat. We extrapolated the landscape-scale model to the entire Gunnison Basin because of conservation concerns for this species. We believe this predictive surface is a valuable tool which can be incorporated into land use and conservation planning as well the assessment of

  14. Update regarding the society of American Gastrointestinal and Endoscopic Surgeons (SAGES) grant distribution and impact on recipient's academic career.

    Science.gov (United States)

    DuCoin, Christopher; Petersen, Rebecca P; Urbach, David; Aggarwal, Rajesh; Madan, Atul K; Pryor, Aurora D

    2018-07-01

    Small seed grants strongly impact academic careers, result in future funding, and lead to increased involvement in surgical societies. We hypothesize that, in accordance with the SAGES Research and Career Development committee mission, there has been a shift in grant support from senior faculty to residents and junior faculty. We hypothesize that these junior physician-researchers are subsequently remaining involved with SAGES and advancing within their academic institutions. All current and previous SAGES grant recipients were surveyed through Survey Monkey™. Questions included current academic status and status at time of grant, ensuing funding, publication and presentation of grant, and impact on career. Results were verified through a Medline query. SAGES database was examined for involvement within the society. Respondent data were compared to 2009 data. One hundred and ninety four grants were awarded to 167 recipients. Of those, 75 investigators responded for a response rate 44.9%. 32% were trainees, 43% assistant professors, 16% associate professors, 3% full professors, 3% professors with tenure, and 3% in private practice. This is a shift from 2009 data with a considerable increase in funding of trainees by 19% and assistant professors by 10% and a decrease in funding of associate professors by 5% and professors by 10%. 41% of responders who were awarded the grant as assistant or associate professors had advanced to full professor and 99% were currently in academic medicine. Eighty-two percent indicated that they had completed their project and 93% believed that the award helped their career. All responders remained active in SAGES. SAGES has chosen to reallocate an increased percentage of grant money to more junior faculty members and residents. It appears that these grants may play a role in keeping recipients interested in the academic surgical realm and involved in the society while simultaneously helping them advance in faculty rank.

  15. Corticosterone metabolite concentrations in greater sage-grouse are positively associated with the presence of cattle grazing

    Science.gov (United States)

    Jankowski, M.D.; Russell, Robin E.; Franson, J. Christian; Dusek, Robert J.; Hines, M.K.; Gregg, M.; Hofmeister, Erik K.

    2014-01-01

    The sagebrush biome in the western United States is home to the imperiled greater sage-grouse (Centrocercus urophasianus) and encompasses rangelands used for cattle production. Cattle grazing activities have been implicated in the range-wide decline of the sage-grouse, but no studies have investigated the relationship between the physiological condition of sage-grouse and the presence of grazing cattle. We sampled 329 sage-grouse across four sites (two grazed and two ungrazed) encompassing 13 600 km2 during the spring and late summer–early autumn of 2005 to evaluate whether demographic factors, breeding status, plasma protein levels, and residence in a cattle-grazed habitat were associated with the stress hormone corticosterone. Corticosterone was measured in feces as immunoreactive corticosterone metabolites (ICM). Males captured during the lekking season exhibited higher ICM levels than all others. Prenesting female sage-grouse captured in a grazed site had higher ICM levels than those in ungrazed sites and prenesting female plasma protein levels were negatively correlated with ICM concentrations. With the use of a small-scale spatial model, we identified a positive correlation between cattle pat count and sage-grouse ICM levels. Our model indicated that ICM levels increased by 2.60 ng · g-1 dry feces for every increase in the number of cow pats found in the vicinity. Management practices will benefit from future research regarding the consistency and mechanism(s) responsible for this association and, importantly, how ICM levels and demographic rates are related in this species of conservation concern.

  16. Discovery of a new Wolf-Rayet star using SAGE-LMC

    OpenAIRE

    Gvaramadze, V. V.; Chené, A. -N.; Kniazev, A. Y.; Schnurr, O.

    2011-01-01

    We report the first-ever discovery of an extragalactic Wolf-Rayet (WR)star with Spitzer. A new WR star in the Large Magellanic Cloud (LMC) was revealed via detection of its circumstellar shell using 24 {\\mu}m images obtained in the framework of the Spitzer Survey of the Large Magellanic Cloud (SAGE-LMC). Subsequent spectroscopic bservations with the Gemini South resolved the central star in two components, one of which is a WN3b+abs star, while the second one is a B0V star. We consider the lo...

  17. Alternaria Leaf Spot on Mealycup Sage (Salvia farinacea Benth.) Caused by Alternaria alternata (Fr.) Keissler

    OpenAIRE

    Hiromitsu, NEGISHI; Kazuo, SUYAMA; Faculty of Agriculture,Tokyo University of Agriculture; Faculty of Agriculture,Tokyo University of Agriculture

    2002-01-01

    In June 1995, a disease causing round to irregular-shaped, water-soaked, brown to blackish brown spots on mealycup sage (Salvia farinacea Benth.) was found in Atsugi-shi, Kanagawa Prefecture, Japan. The symptoms were seen only on leaves, not on neither flower petals or stems. The disease was also found in Setagaya-ku, Tokyo, Memambetsu-cho, Hokkaido and Shimoda-shi and Matsuzaki-cho, Shizuoka. An Alternaria sp. was frequently isolated from these diseased plants. The isolates were severely pat...

  18. PWR fuel physico chemistry. Improvements of the Sage code to compute thermochemical balance in PWR fuel

    International Nuclear Information System (INIS)

    Garcia, P.; Baron, D.; Piron, J.P.

    1993-02-01

    A physicochemical survey of high burnup fuel has been undertaken in the context of a 3-party action (CEA Cadarache - EDF/DER - FRAMATOME). One of the tasks involved consists in adapting the SAGE code for assessment of the thermochemical equilibria of fission products in solution in the fuel matrix. This paper describes the first stage of this task. Even if other improvements are planned, the oxid oxygen potentials are yet properly reproduced for the simulated burnup. (authors). 63 figs., 4 tabs., 41 refs

  19. Intraseasonal variation in survival and probable causes of mortality in greater sage-grouse Centrocercus urophasianus

    Science.gov (United States)

    Blomberg, Erik J.; Gibson, Daniel; Sedinger, James S.; Casazza, Michael L.; Coates, Peter S.

    2013-01-01

    The mortality process is a key component of avian population dynamics, and understanding factors that affect mortality is central to grouse conservation. Populations of greater sage-grouse Centrocercus urophasianus have declined across their range in western North America. We studied cause-specific mortality of radio-marked sage-grouse in Eureka County, Nevada, USA, during two seasons, nesting (2008-2012) and fall (2008-2010), when survival was known to be lower compared to other times of the year. We used known-fate and cumulative incidence function models to estimate weekly survival rates and cumulative risk of cause-specific mortalities, respectively. These methods allowed us to account for temporal variation in sample size and staggered entry of marked individuals into the sample to obtain robust estimates of survival and cause-specific mortality. We monitored 376 individual sage-grouse during the course of our study, and investigated 87 deaths. Predation was the major source of mortality, and accounted for 90% of all mortalities during our study. During the nesting season (1 April - 31 May), the cumulative risk of predation by raptors (0.10; 95% CI: 0.05-0.16) and mammals (0.08; 95% CI: 0.03-013) was relatively equal. In the fall (15 August - 31 October), the cumulative risk of mammal predation was greater (M(mam) = 0.12; 95% CI: 0.04-0.19) than either predation by raptors (M(rap) = 0.05; 95% CI: 0.00-0.10) or hunting harvest (M(hunt) = 0.02; 95% CI: 0.0-0.06). During both seasons, we observed relatively few additional sources of mortality (e.g. collision) and observed no evidence of disease-related mortality (e.g. West Nile Virus). In general, we found little evidence for intraseasonal temporal variation in survival, suggesting that the nesting and fall seasons represent biologically meaningful time intervals with respect to sage-grouse survival.

  20. SAGE measurements of the stratospheric aerosol dispersion and loading from the Soufriere Volcano

    Science.gov (United States)

    Mccormick, M. P.; Kent, G. S.; Yue, G. K.; Cunnold, D. M.

    1981-01-01

    Explosions of the Soufriere volcano on the Caribbean Island of St. Vincent reduced two major stratospheric plumes which the stratospheric aerosol and gas experiment (SAGE) satellite tracked to West Africa and the North Atlantic Ocean. The total mass of the stratospheric ejecta measured is less than 0.5% of the global stratospheric aerosol burden. No significant temperature or climate perturbation is expected. It is found that the movement and dispersion of the plumes agree with those deduced from high altitude meteorological data and dispersion theory. The stratospheric aerosol dispersion and loading from the Soufrier volcano was measured.

  1. Evaluating greater sage-grouse seasonal space use relative to leks: Implications for surface use designations in sagebrush ecosystems

    Science.gov (United States)

    Casazza, Michael L.; Coates, Peter S.

    2013-01-01

    The development of anthropogenic structures, especially those related to energy resources, in sagebrush ecosystems is an important concern among developers, conservationists, and land managers in relation to greater sage-grouse (Centrocercus urophasianus; hereafter, sage-grouse) populations. Sage-grouse are dependent on sagebrush ecosystems to meet their seasonal life-phase requirements, and research indicates that anthropogenic structures can adversely affect sage-grouse populations. Land management agencies have attempted to reduce the negative effects of anthropogenic development by assigning surface use (SU) designations, such as no surface occupancy, to areas around leks (breeding grounds). However, rationale for the size of these areas is often challenged. To help inform this issue, we used a spatial analysis of sage-grouse utilization distributions (UDs) to quantify seasonal (spring, summer and fall, winter) sage-grouse space use in relation to leks. We sampled UDs from 193 sage-grouse (11,878 telemetry locations) across 4 subpopulations within the Bi-State Distinct Population Segment (DPS, bordering California and Nevada) during 2003–2009. We quantified the volume of each UD (vUD) within a range of areas that varied in size and were centered on leks, up to a distance of 30 km from leks. We also quantified the percentage of nests within those areas. We then estimated the diminishing gains of vUD as area increased and produced continuous response curves that allow for flexibility in land management decisions. We found nearly 90% of the total vUD (all seasons combined) was contained within 5 km of leks, and we identified variation in vUD for a given distance related to season and migratory status. Five kilometers also represented the 95th percentile of the distribution of nesting distances. Because diminishing gains of vUD was not substantial until distances exceeded 8 km, managers should consider the theoretical optimal distances for SU designation

  2. Are Economists More Likely to Hold Stocks?

    DEFF Research Database (Denmark)

    Christiansen, Charlotte; Joensen, Eyðfrið Juanna Schrøter; Rangvid, Jesper

    A unique data set enables us to test the hypothesis that due to informational advantages economists are more likely to hold stocks than otherwise identical investors. Weconfirm that economists have a significantly higher probability of participating in the stockmarket than investors with any other...

  3. 12 CFR 1732.7 - Record hold.

    Science.gov (United States)

    2010-01-01

    ... Banking OFFICE OF FEDERAL HOUSING ENTERPRISE OVERSIGHT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SAFETY AND SOUNDNESS RECORD RETENTION Record Retention Program § 1732.7 Record hold. (a) Definition. For... Enterprise or OFHEO that the Enterprise is to retain records relating to a particular issue in connection...

  4. Venezuela and Chavez: What the Future Holds...

    Science.gov (United States)

    2010-04-01

    government made public 26 presidential decrees that had been enacted. These acts: ...covered such areas as tourism , railways, social security, and...great prosperity or a harbinger of doom to the region, and for this reason the United States must prepare for the many paths that the future holds

  5. Empowerment Amongst Teachers Holding Leadership Positions

    Science.gov (United States)

    Avidov-Ungar, Orit; Friedman, Izhak; Olshtain, Elite

    2014-01-01

    This study used semi-structured in-depth interviews to explore empowerment patterns among teachers who hold leadership positions in school. Our qualitative analysis presents a hierarchical ladder with three types of empowerment amongst these teachers, ranging from limited empowerment through rewarding empowerment to change-enhancing empowerment.…

  6. Biosketch Ashok Venkitaraman holds the Ursula Zoellner ...

    Indian Academy of Sciences (India)

    ashok

    Ashok Venkitaraman holds the Ursula Zoellner Professorship of Cancer Research at the University of Cambridge, and is the Director of the Medical Research Council. (MRC) Cancer Cell Unit there. He learnt and practiced medicine at the Christian. Medical College, Vellore, before completing his Ph.D. at University College ...

  7. Package Holds Five Monolithic Microwave Integrated Circuits

    Science.gov (United States)

    Mysoor, Narayan R.; Decker, D. Richard; Olson, Hilding M.

    1996-01-01

    Packages protect and hold monolithic microwave integrated circuit (MMIC) chips while providing dc and radio-frequency (RF) electrical connections for chips undergoing development. Required to be compact, lightweight, and rugged. Designed to minimize undesired resonances, reflections, losses, and impedance mismatches.

  8. Deformable Registration for Longitudinal Breast MRI Screening.

    Science.gov (United States)

    Mehrabian, Hatef; Richmond, Lara; Lu, Yingli; Martel, Anne L

    2018-04-13

    MRI screening of high-risk patients for breast cancer provides very high sensitivity, but with a high recall rate and negative biopsies. Comparing the current exam to prior exams reduces the number of follow-up procedures requested by radiologists. Such comparison, however, can be challenging due to the highly deformable nature of breast tissues. Automated co-registration of multiple scans has the potential to aid diagnosis by providing 3D images for side-by-side comparison and also for use in CAD systems. Although many deformable registration techniques exist, they generally have a large number of parameters that need to be optimized and validated for each new application. Here, we propose a framework for such optimization and also identify the optimal input parameter set for registration of 3D T 1 -weighted MRI of breast using Elastix, a widely used and freely available registration tool. A numerical simulation study was first conducted to model the breast tissue and its deformation through finite element (FE) modeling. This model generated the ground truth for evaluating the registration accuracy by providing the deformation of each voxel in the breast volume. An exhaustive search was performed over various values of 7 registration parameters (4050 different combinations of parameters were assessed) and the optimum parameter set was determined. This study showed that there was a large variation in the registration accuracy of different parameter sets ranging from 0.29 mm to 2.50 mm in median registration error and 3.71 mm to 8.90 mm in 95 percentile of the registration error. Mean registration errors of 0.32 mm, 0.29 mm, and 0.30 mm and 95 percentile errors of 3.71 mm, 5.02 mm, and 4.70 mm were obtained by the three best parameter sets. The optimal parameter set was applied to consecutive breast MRI scans of 13 patients. A radiologist identified 113 landmark pairs (~ 11 per patient) which were used to assess registration accuracy. The results demonstrated that

  9. Optical registration of spaceborne low light remote sensing camera

    Science.gov (United States)

    Li, Chong-yang; Hao, Yan-hui; Xu, Peng-mei; Wang, Dong-jie; Ma, Li-na; Zhao, Ying-long

    2018-02-01

    For the high precision requirement of spaceborne low light remote sensing camera optical registration, optical registration of dual channel for CCD and EMCCD is achieved by the high magnification optical registration system. System integration optical registration and accuracy of optical registration scheme for spaceborne low light remote sensing camera with short focal depth and wide field of view is proposed in this paper. It also includes analysis of parallel misalignment of CCD and accuracy of optical registration. Actual registration results show that imaging clearly, MTF and accuracy of optical registration meet requirements, it provide important guarantee to get high quality image data in orbit.

  10. Three dimensional image alignment, registration and fusion

    International Nuclear Information System (INIS)

    Treves, S.T.; Mitchell, K.D.; Habboush, I.H.

    1998-01-01

    Combined assessment of three dimensional anatomical and functional images (SPECT, PET, MRI, CT) is useful to determine the nature and extent of lesions in many parts of the body. Physicians principally rely on their spatial sense of mentally re-orient and overlap images obtained with different imaging modalities. Objective methods that enable easy and intuitive image registration can help the physician arrive at more optimal diagnoses and better treatment decisions. This review describes a simple, intuitive and robust image registration approach developed in our laboratory. It differs from most other registration techniques in that it allows the user to incorporate all of the available information within the images in the registration process. This method takes full advantage of the ability of knowledgeable operators to achieve image registration and fusion using an intuitive interactive visual approach. It can register images accurately and quickly without the use of elaborate mathematical modeling or optimization techniques. The method provides the operator with tools to manipulate images in three dimensions, including visual feedback techniques to assess the accuracy of registration (grids, overlays, masks, and fusion of images in different colors). Its application is not limited to brain imaging and can be applied to images from any region in the body. The overall effect is a registration algorithm that is easy to implement and can achieve accuracy on the order of one pixel

  11. Sulcal set optimization for cortical surface registration.

    Science.gov (United States)

    Joshi, Anand A; Pantazis, Dimitrios; Li, Quanzheng; Damasio, Hanna; Shattuck, David W; Toga, Arthur W; Leahy, Richard M

    2010-04-15

    Flat mapping based cortical surface registration constrained by manually traced sulcal curves has been widely used for inter subject comparisons of neuroanatomical data. Even for an experienced neuroanatomist, manual sulcal tracing can be quite time consuming, with the cost increasing with the number of sulcal curves used for registration. We present a method for estimation of an optimal subset of size N(C) from N possible candidate sulcal curves that minimizes a mean squared error metric over all combinations of N(C) curves. The resulting procedure allows us to estimate a subset with a reduced number of curves to be traced as part of the registration procedure leading to optimal use of manual labeling effort for registration. To minimize the error metric we analyze the correlation structure of the errors in the sulcal curves by modeling them as a multivariate Gaussian distribution. For a given subset of sulci used as constraints in surface registration, the proposed model estimates registration error based on the correlation structure of the sulcal errors. The optimal subset of constraint curves consists of the N(C) sulci that jointly minimize the estimated error variance for the subset of unconstrained curves conditioned on the N(C) constraint curves. The optimal subsets of sulci are presented and the estimated and actual registration errors for these subsets are computed. Copyright 2009 Elsevier Inc. All rights reserved.

  12. Communication in palliative care: the applicability of the SAGE and THYME model in Singapore.

    Science.gov (United States)

    Martin, Ang Seng Hock; Costello, John; Griffiths, Jane

    2017-06-02

    Majority of the progress and development in palliative care in the last decade has been improvements in physical aspects of treatment, namely pain and symptom management. Psychosocial aspects of care have improved, although not enough to meet the needs of many patients and family members. This is evident in many parts of the world and notably in Singapore, where palliative care is seen as an emerging medical and nursing specialty. To discuss the implementation of the SAGE and THYME communication model in a palliative care context. The article examines the use of the model and how its implementation can improve communication between patients and nurses. The model works by reviewing contemporary developments made in relation to improving communication in palliative care. These include, highlighting the importance of meeting individual needs, therapeutic relationship building, and advanced communication training within a Singaporean context. The implementation of the SAGE and THYME model can be a useful way of enabling nurses to improve and maintain effective communication in a medically dominated health care system. The challenges and constraints in educating and training nurses with limited skills in palliative care, forms part of the review, including the cultural and attitude constraints specific to Singaporean palliative care.

  13. SAGE-VAR: AN INFRARED SURVEY OF VARIABILITY IN THE MAGELLANIC CLOUDS

    Energy Technology Data Exchange (ETDEWEB)

    Riebel, D. [Department of Physics, United States Naval Academy, 572 C Holloway Road, Annapolis, MD 21402 (United States); Boyer, M. L. [Observational Cosmology Laboratory, Code 665, NASA Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Srinivasan, S. [Academia Sinica, Institute of Astronomy and Astrophysics, P.O. Box 23-141, Taipei 10617, Taiwan (China); Whitelock, P.; Feast, M. [Astrophysics, Cosmology and Gravity Centre, Astronomy Department, University of Cape Town, Rondebosch 7701 (South Africa); Meixner, M.; Shiao, B. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Babler, B.; Meade, M.; Whitney, B. [Department of Astronomy, University of Wisconsin-Madison, Madison, WI 53706 (United States); Groenewegen, M. A. T. [Royal Observatory of Belgium, Ringlaan 3, B-1180 Brussels (Belgium); Ita, Y., E-mail: riebel.d@gmail.com [Astronomical Institute, Graduate School of Science, Tohoku University, 6-3 Aramaki Aoba, Aoba-ku, Sendai, Miyagi 980-8578 (Japan)

    2015-07-01

    We present the first results from the Surveying the Agents of Galaxy Evolution (SAGE)-Var program, a follow up to the Spitzer legacy program SAGE (Meixner et al.). We obtained four epochs of photometry at 3.6 and 4.5 μm covering the bar of the LMC and the central region of the SMC in order to probe the variability of extremely red sources missed by variability surveys conducted at shorter wavelengths, and to provide additional epochs of observation for known variables. Our six total epochs of observations allow us to probe infrared (IR) variability on 15 different timescales ranging from ∼20 days to ∼5 yr. Out of a full catalog of 1 717 554 (LMC) and 457 760 (SMC) objects, we find 10 (LMC) and 6 (SMC) large amplitude Asymptotic Giant Branch (AGB) variables without optically measured variability owing to circumstellar dust obscuration. The catalog also contains multiple observations of known AGB variables, type I and II Cepheids, eclipsing variables, R CrB stars, and young stellar objects, which will be discussed in following papers. Here we present IR Period–Luminosity (PL) relations for classical Cepheids in the Magellanic Clouds, as well as improved PL relationships for AGB stars pulsating in the fundamental mode using mean magnitudes constructed from six epochs of observations.

  14. SAGE aerosol measurements. Volume 1, February 21, 1979 to December 31, 1979

    International Nuclear Information System (INIS)

    Mccormick, M.P.

    1985-10-01

    The Stratospheric Aerosol and Gas Experiment (SAGE) satellite system, launched on February 18, 1979, provides profiles of aerosol extinction, ozone concentration, and nitrogen dioxide concentration between about 80 N and 80 S. Zonal averages, separated into sunrise and sunset events, and seasonal averages of the aerosol extinction at 1.00 microns and 0.45 microns ratios of the aerosol extinction to the molecular extinction at 1.00 microns, and ratios of the aerosol extinction at 0.45 microns to the aerosol extinction at 1.00 microns are given. The averages for 1979 are shown in tables and in profile and contour plots (as a function of altitude and latitude). In addition, temperature data provided by the National Oceanic and Atmospheric Administration (NOAA) for the time and location of each SAGE measurement are averaged and shown in a similar format. Typical values of the peak aerosol extinction were 0.0001 to 0.0002 km at 1.00 microns depth values for the 1.00 microns channel varied between 0.001 and 0.002 over all latitudes

  15. SQUAT: A web tool to mine human, murine and avian SAGE data

    Directory of Open Access Journals (Sweden)

    Besson Jérémy

    2008-09-01

    Full Text Available Abstract Background There is an increasing need in transcriptome research for gene expression data and pattern warehouses. It is of importance to integrate in these warehouses both raw transcriptomic data, as well as some properties encoded in these data, like local patterns. Description We have developed an application called SQUAT (SAGE Querying and Analysis Tools which is available at: http://bsmc.insa-lyon.fr/squat/. This database gives access to both raw SAGE data and patterns mined from these data, for three species (human, mouse and chicken. This database allows to make simple queries like "In which biological situations is my favorite gene expressed?" as well as much more complex queries like: ≪what are the genes that are frequently co-over-expressed with my gene of interest in given biological situations?≫. Connections with external web databases enrich biological interpretations, and enable sophisticated queries. To illustrate the power of SQUAT, we show and analyze the results of three different queries, one of which led to a biological hypothesis that was experimentally validated. Conclusion SQUAT is a user-friendly information retrieval platform, which aims at bringing some of the state-of-the-art mining tools to biologists.

  16. Control of the phytoplankton response during the SAGE experiment: A synthesis

    Science.gov (United States)

    Peloquin, Jill; Hall, Julie; Safi, Karl; Ellwood, Michael; Law, Cliff S.; Thompson, Karen; Kuparinen, Jorma; Harvey, Michael; Pickmere, Stuart

    2011-03-01

    The SOLAS Air-Sea Gas Exchange (SAGE) experiment was conducted in Sub-Antarctic waters off the east coast of the South Island of New Zealand in the late summer of 2004. This mesoscale iron enrichment experiment was unique in that chlorophyll a (chl a) and primary productivity were only 2× OUT stations values toward the end of the experiment and this enhancement was due to increased activity of non-diatomaceous species. In addition, this enhancement in activity appeared to occur without a significant build up of particulate organic carbon. Picoeukaryotes (statistically significant increase, a doubling in biomass. To better understand the controls of phytoplankton growth and biomass, we present results from a series of on-deck perturbation experiments conducted during SAGE. Results suggest that the pico-dominated phytoplankton assemblage was only weakly inhibited by iron. Diatoms with high growth rates comprised a small (food web. A primary implication of this study is that any iron-mediated gain in fixed carbon with this set of environmental conditions has a high probability of being recycled in surface waters.

  17. Transcriptome analysis of Schistosoma mansoni larval development using serial analysis of gene expression (SAGE).

    Science.gov (United States)

    Taft, A S; Vermeire, J J; Bernier, J; Birkeland, S R; Cipriano, M J; Papa, A R; McArthur, A G; Yoshino, T P

    2009-04-01

    Infection of the snail, Biomphalaria glabrata, by the free-swimming miracidial stage of the human blood fluke, Schistosoma mansoni, and its subsequent development to the parasitic sporocyst stage is critical to establishment of viable infections and continued human transmission. We performed a genome-wide expression analysis of the S. mansoni miracidia and developing sporocyst using Long Serial Analysis of Gene Expression (LongSAGE). Five cDNA libraries were constructed from miracidia and in vitro cultured 6- and 20-day-old sporocysts maintained in sporocyst medium (SM) or in SM conditioned by previous cultivation with cells of the B. glabrata embryonic (Bge) cell line. We generated 21 440 SAGE tags and mapped 13 381 to the S. mansoni gene predictions (v4.0e) either by estimating theoretical 3' UTR lengths or using existing 3' EST sequence data. Overall, 432 transcripts were found to be differentially expressed amongst all 5 libraries. In total, 172 tags were differentially expressed between miracidia and 6-day conditioned sporocysts and 152 were differentially expressed between miracidia and 6-day unconditioned sporocysts. In addition, 53 and 45 tags, respectively, were differentially expressed in 6-day and 20-day cultured sporocysts, due to the effects of exposure to Bge cell-conditioned medium.

  18. Can reliable sage-grouse lek counts be obtained using aerial infrared technology

    Science.gov (United States)

    Gillette, Gifford L.; Coates, Peter S.; Petersen, Steven; Romero, John P.

    2013-01-01

    More effective methods for counting greater sage-grouse (Centrocercus urophasianus) are needed to better assess population trends through enumeration or location of new leks. We describe an aerial infrared technique for conducting sage-grouse lek counts and compare this method with conventional ground-based lek count methods. During the breeding period in 2010 and 2011, we surveyed leks from fixed-winged aircraft using cryogenically cooled mid-wave infrared cameras and surveyed the same leks on the same day from the ground following a standard lek count protocol. We did not detect significant differences in lek counts between surveying techniques. These findings suggest that using a cryogenically cooled mid-wave infrared camera from an aerial platform to conduct lek surveys is an effective alternative technique to conventional ground-based methods, but further research is needed. We discuss multiple advantages to aerial infrared surveys, including counting in remote areas, representing greater spatial variation, and increasing the number of counted leks per season. Aerial infrared lek counts may be a valuable wildlife management tool that releases time and resources for other conservation efforts. Opportunities exist for wildlife professionals to refine and apply aerial infrared techniques to wildlife monitoring programs because of the increasing reliability and affordability of this technology.

  19. SAGE-VAR: AN INFRARED SURVEY OF VARIABILITY IN THE MAGELLANIC CLOUDS

    International Nuclear Information System (INIS)

    Riebel, D.; Boyer, M. L.; Srinivasan, S.; Whitelock, P.; Feast, M.; Meixner, M.; Shiao, B.; Babler, B.; Meade, M.; Whitney, B.; Groenewegen, M. A. T.; Ita, Y.

    2015-01-01

    We present the first results from the Surveying the Agents of Galaxy Evolution (SAGE)-Var program, a follow up to the Spitzer legacy program SAGE (Meixner et al.). We obtained four epochs of photometry at 3.6 and 4.5 μm covering the bar of the LMC and the central region of the SMC in order to probe the variability of extremely red sources missed by variability surveys conducted at shorter wavelengths, and to provide additional epochs of observation for known variables. Our six total epochs of observations allow us to probe infrared (IR) variability on 15 different timescales ranging from ∼20 days to ∼5 yr. Out of a full catalog of 1 717 554 (LMC) and 457 760 (SMC) objects, we find 10 (LMC) and 6 (SMC) large amplitude Asymptotic Giant Branch (AGB) variables without optically measured variability owing to circumstellar dust obscuration. The catalog also contains multiple observations of known AGB variables, type I and II Cepheids, eclipsing variables, R CrB stars, and young stellar objects, which will be discussed in following papers. Here we present IR Period–Luminosity (PL) relations for classical Cepheids in the Magellanic Clouds, as well as improved PL relationships for AGB stars pulsating in the fundamental mode using mean magnitudes constructed from six epochs of observations

  20. Dry fermented buffalo sausage with sage oil extract: Safety and quality

    Directory of Open Access Journals (Sweden)

    Ibrahim, Hayam M.

    2010-03-01

    Full Text Available Sage oil extract was added during the preparation of dry fermented buffalo meat sausage. Some chemical, microbial and sensory characteristics of sausages were evaluated during the ripening period. In particular, pH, lipid oxidation, biogenic amines and micro flora were analyzed. Results of this study pointed out that sage oil extract as natural antioxidant could be utilized in dry fermented sausage, prepared from buffalo meat, in order to obtain a final product within acceptable lipid oxidation and biogenic amine levels, as well as improved sensory quality.Extractos de aceite de salvia fueron añadidos a embutidos de carne de búfalo. Las características químicas, microbiológicas y sensoriales de los embutidos fueron evaluadas durante el periodo de maduración. En particular, pH, oxidación lipídica, aminas biogénicas y microflora fueron analizadas. Los resultados de este estudio indican que los extractos de aceite de salvia, como antioxidantes naturales, podrían ser utilizados en embutidos preparados con carnes de búfalo, con objeto de obtener un producto final con unos niveles de aminas biogénicas y de oxidación lipídica aceptable, así como con una calidad sensorial mejorada.

  1. 12 CFR 1252.1 - Enterprise portfolio holding criteria.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Enterprise portfolio holding criteria. 1252.1 Section 1252.1 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ENTERPRISES PORTFOLIO HOLDINGS § 1252.1 Enterprise portfolio holding criteria. The Enterprises are required to comply with the portfolio holdings...

  2. 12 CFR 583.20 - Savings and loan holding company.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Savings and loan holding company. 583.20... REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.20 Savings and loan holding company. The term savings and loan holding company means any company that directly or indirectly controls a savings...

  3. 76 FR 20459 - Savings and Loan Holding Company Application

    Science.gov (United States)

    2011-04-12

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision Savings and Loan Holding Company... concerning the following information collection. Title of Proposal: Savings and Loan Holding Company... officer of a savings and loan holding company, or any individual who owns, controls, or holds with power...

  4. Regulation of Cross-holdings between European Companies

    DEFF Research Database (Denmark)

    Sørensen, Karsten Engsig

    2003-01-01

    Cross-holdings can be a barrier to takeovers, and they may have other disadvantages. This article analyses how cross-holdings may be regulated to avoid these negative effects.......Cross-holdings can be a barrier to takeovers, and they may have other disadvantages. This article analyses how cross-holdings may be regulated to avoid these negative effects....

  5. 12 CFR 225.124 - Foreign bank holding companies.

    Science.gov (United States)

    2010-01-01

    ... SYSTEM BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations Financial Holding Companies Interpretations § 225.124 Foreign bank holding companies. (a) Effective December 1, 1971, the... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Foreign bank holding companies. 225.124 Section...

  6. Saskatchewan Energy Holdings Ltd. consolidated financial statements

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The consolidated financial statements of Saskatchewan Energy Holdings Ltd. (formerly Saskatchewan Energy Corporation) as of December 31, 1990, and the consolidated statements of earnings and retained earnings and changes in cash position for the year are presented. Data include an inventory of supplies, natural gas in storage, property, plant and equipment. Financial statements are also presented for the year ending December 31, 1989, with comparative figures for the seven months ending December 31, 1988.

  7. Saskatchewan Energy Holdings Ltd. consolidated financial statements

    International Nuclear Information System (INIS)

    1991-01-01

    The consolidated financial statements of Saskatchewan Energy Holdings Ltd. (formerly Saskatchewan Energy Corporation) as of December 31, 1990, and the consolidated statements of earnings and retained earnings and changes in cash position for the year are presented. Data include an inventory of supplies, natural gas in storage, property, plant and equipment. Financial statements are also presented for the year ending December 31, 1989, with comparative figures for the seven months ending December 31, 1988

  8. The genetic network of greater sage-grouse: Range-wide identification of keystone hubs of connectivity

    Science.gov (United States)

    Todd B. Cross; Michael K. Schwartz; David E. Naugle; Brad C. Fedy; Jeffrey R. Row; Sara J. Oyler-McCance

    2018-01-01

    Genetic networks can characterize complex genetic relationships among groups of individuals, which can be used to rank nodes most important to the overall connectivity of the system. Ranking allows scarce resources to be guided toward nodes integral to connectivity. The greater sage-grouse (Centrocercus urophasianus) is a species of conservation concern that breeds on...

  9. Greater Sage-Grouse Habitat Use and Population Demographics at the Simpson Ridge Wind Resource Area, Carbon County, Wyoming

    Energy Technology Data Exchange (ETDEWEB)

    Gregory D. Johnson; Chad W. LeBeau; Ryan Nielsen; Troy Rintz; Jamey Eddy; Matt Holloran

    2012-03-27

    This study was conducted to obtain baseline data on use of the proposed Simpson Ridge Wind Resource Area (SRWRA) in Carbon County, Wyoming by greater sage-grouse. The first two study years were designed to determine pre-construction seasonally selected habitats and population-level vital rates (productivity and survival). The presence of an existing wind energy facility in the project area, the PacifiCorp Seven Mile Hill (SMH) project, allowed us to obtain some information on initial sage-grouse response to wind turbines the first two years following construction. To our knowledge these are the first quantitative data on sage-grouse response to an existing wind energy development. This report presents results of the first two study years (April 1, 2009 through March 30, 2011). This study was selected for continued funding by the National Wind Coordinating Collaborative Sage-Grouse Collaborative (NWCC-SGC) and has been ongoing since March 30, 2011. Future reports summarizing results of this research will be distributed through the NWCC-SGC. To investigate population trends through time, we determined the distribution and numbers of males using leks throughout the study area, which included a 4-mile radius buffer around the SRWRA. Over the 2-year study, 116 female greater sage-grouse were captured by spotlighting and use of hoop nets on roosts surrounding leks during the breeding period. Radio marked birds were located anywhere from twice a week to once a month, depending on season. All radio-locations were classified to season. We developed predictor variables used to predict success of fitness parameters and relative probability of habitat selection within the SRWRA and SMH study areas. Anthropogenic features included paved highways, overhead transmission lines, wind turbines and turbine access roads. Environmental variables included vegetation and topography features. Home ranges were estimated using a kernel density estimator. We developed resource selection

  10. Characterization of the global profile of genes expressed in cervical epithelium by Serial Analysis of Gene Expression (SAGE

    Directory of Open Access Journals (Sweden)

    Piña-Sanchez Patricia

    2005-09-01

    Full Text Available Abstract Background Serial Analysis of Gene Expression (SAGE is a new technique that allows a detailed and profound quantitative and qualitative knowledge of gene expression profile, without previous knowledge of sequence of analyzed genes. We carried out a modification of SAGE methodology (microSAGE, useful for the analysis of limited quantities of tissue samples, on normal human cervical tissue obtained from a donor without histopathological lesions. Cervical epithelium is constituted mainly by cervical keratinocytes which are the targets of human papilloma virus (HPV, where persistent HPV infection of cervical epithelium is associated with an increase risk for developing cervical carcinomas (CC. Results We report here a transcriptome analysis of cervical tissue by SAGE, derived from 30,418 sequenced tags that provide a wealth of information about the gene products involved in normal cervical epithelium physiology, as well as genes not previously found in uterine cervix tissue involved in the process of epidermal differentiation. Conclusion This first comprehensive and profound analysis of uterine cervix transcriptome, should be useful for the identification of genes involved in normal cervix uterine function, and candidate genes associated with cervical carcinoma.

  11. Restoration handbook for sagebrush steppe ecosystems with emphasis on greater sage-grouse habitat - Part 3: Site level restoration decisions

    Science.gov (United States)

    David A. Pyke; Jeanne C. Chambers; Mike Pellant; Richard F. Miller; Jeffrey L. Beck; Paul S. Doescher; Bruce A. Roundy; Eugene W. Schupp; Steven T. Knick; Mark Brunson; James D. McIver

    2017-01-01

    Sagebrush steppe ecosystems in the United States currently (2016) occur on only about one-half of their historical land area because of changes in land use, urban growth, and degradation of land, including invasions of non-native plants. The existence of many animal species depends on the existence of sagebrush steppe habitat. The greater sage-grouse (Centrocercus...

  12. Forbs: Foundation for restoration of monarch butterflies, other pollinators, and greater sage-grouse in the western United States

    Science.gov (United States)

    Kas Dumroese; Tara Luna; Jeremy Pinto; Thomas D. Landis

    2016-01-01

    Monarch butterflies (Danaus plexippus), other pollinators, and Greater Sage-Grouse (Centrocercus urophasianus) are currently the focus of increased conservation efforts. Federal attention on these fauna is encouraging land managers to develop conservation strategies, often without corresponding financial resources. This could foster a myopic approach when...

  13. Nesting ecology of greater sage-grouse Centrocercus urophasianus at the eastern edge of their historic distribution

    Science.gov (United States)

    Katie M. Herman-Brunson; Kent C. Jensen; Nicholas W. Kaczor; Christopher C. Swanson; Mark A. Rumble; Robert W. Klaver

    2009-01-01

    Greater sage-grouse Centrocercus urophasianus populations in North Dakota declined approximately 67% between 1965 and 2003, and the species is listed as a Priority Level 1 Species of Special Concern by the North Dakota Game and Fish Department. The habitat and ecology of the species at the eastern edge of its historical range is largely unknown. We...

  14. Formulation of sage essential oil (Salvia officinalis, L.) monoterpenes into chitosan hydrogels and permeation study with GC-MS analysis.

    Science.gov (United States)

    Kodadová, Alexandra; Vitková, Zuzana; Herdová, Petra; Ťažký, Anton; Oremusová, Jarmila; Grančai, Daniel; Mikuš, Peter

    2015-01-01

    This study deals with the formulation of natural drugs into hydrogels. For the first time, compounds from the sage essential oil were formulated into chitosan hydrogels. A sample preparation procedure for hydrophobic volatile analytes present in a hydrophilic water matrix along with an analytical method based on the gas chromatography coupled with the mass spectrometry (GC-MS) was developed and applied for the evaluation of the identity and quantity of essential oil components in the hydrogels and saline samples. The experimental results revealed that the chitosan hydrogels are suitable for the formulation of sage essential oil. The monoterpene release can be effectively controlled by both chitosan and caffeine concentration in the hydrogels. Permeation experiment, based on a hydrogel with the optimized composition [3.5% (w/w) sage essential oil, 2.0% (w/w) caffeine, 2.5% (w/w) chitosan and 0.1% (w/w) Tween-80] in donor compartment, saline solution in acceptor compartment, and semi-permeable cellophane membrane, demonstrated the useful permeation selectivity. Here, (according to lipophilicity) an enhanced permeation of the bicyclic monoterpenes with antiflogistic and antiseptic properties (eucalyptol, camphor and borneol) and, at the same time, suppressed permeation of toxic thujone (not exceeding its permitted applicable concentration) was observed. These properties highlight the pharmaceutical importance of the developed chitosan hydrogel formulating sage essential oil in the dermal applications.

  15. The antibacterial effect of sage extract (Salvia officinalis) mouthwash against Streptococcus mutans in dental plaque: a randomized clinical trial.

    Science.gov (United States)

    Beheshti-Rouy, Maryam; Azarsina, Mohadese; Rezaie-Soufi, Loghman; Alikhani, Mohammad Yousef; Roshanaie, Ghodratollah; Komaki, Samira

    2015-06-01

    The aim of the study was to evaluate the clinical effects of a mouthwash containing Sage (Salvia officinalis) extracts on Streptococcus mutans (SM) causing dental plaque in school-aged children. A double blind clinical trial study was conducted in a dormitory on 70 girls aged 11-14 years having the same socioeconomic and oral hygiene conditions. These students were randomly divided into 2 groups; the first group (N=35) using Sage mouthwash, and the second group (N=35) using placebo mouthwash without active any ingredients. At the baseline, plaque samples obtained from the buccal surfaces of teeth were sent to laboratory to achieve SM colony count. These tests were reevaluated after 21 days of using the mouthwashes. Statistical data analysis was performed using t-student tests with pSage mouthwash significantly reduced the colony count (P=0.001). Average number of colonies in test group was 3900 per plaque sample at the baseline, and 300 after mouthwash application. In the control group, pre-test colony count was 4400 that was reduced to 4000; although this reduction wasn't significant. The Sage mouthwash effectively reduced the number of Streptococcus mutans in dental plaque.

  16. Quantifying restoration effectiveness using multi-scale habitat models: Implications for sage-grouse in the Great Basin

    Science.gov (United States)

    Robert S. Arkle; David S. Pilliod; Steven E. Hanser; Matthew L. Brooks; Jeanne C. Chambers; James B. Grace; Kevin C. Knutson; David A. Pyke; Justin L. Welty; Troy A. Wirth

    2014-01-01

    A recurrent challenge in the conservation of wide-ranging, imperiled species is understanding which habitats to protect and whether we are capable of restoring degraded landscapes. For Greater Sage-grouse (Centrocercus urophasianus), a species of conservation concern in the western United States, we approached this problem by developing multi-scale empirical models of...

  17. 78 FR 65700 - Notice of Availability of the Utah Greater Sage-Grouse Draft Land Use Plan Amendments and...

    Science.gov (United States)

    2013-11-01

    .../Garfield/Antimony, Pinyon, Warm Springs, House Range, Pony Express, Box Elder, Randolph, Park City, and...) Pinyon Management Framework Plan (MFP) (1978) Warm Springs RMP (1987) House Range RMP (1987) Pony Express... lands identified as having the highest value to maintaining sustainable Greater Sage-Grouse populations...

  18. Spitzer sage survey of the large magellanic cloud. II. Evolved stars and infrared color-magnitude diagrams

    NARCIS (Netherlands)

    Blum, R. D.; Mould, J. R.; Olsen, K. A.; Frogel, J. A.; Meixner, M.; Markwick-Kemper, F.; Indebetouw, R.; Whitney, B.; Meade, M.; Babler, B.; Churchwell, E. B.; Gordon, K.; Engelbracht, C.; For, B. -Q.; Misselt, K.; Vijh, U.; Leitherer, C.; Volk, K.; Points, S.; Reach, W.; Hora, J. L.; Bernard, J. -P.; Boulanger, F.; Bracker, S.; Cohen, M.; Fukui, Y.; Gallagher, J.; Gorjian, V.; Harris, J.; Kelly, D.; Kawamura, A.; Latter, W. B.; Madden, S.; Mizuno, A.; Mizuno, N.; Oey, M. S.; Onishi, T.; Paladini, R.; Panagia, N.; Perez-Gonzalez, P.; Shibai, H.; Sato, S.; Smith, L.; Staveley-Smith, L.; Tielens, A.G.G.M; Ueta, T.; Van Dyk, S.; Zaritsky, D.; Werner, M.J.

    Color-magnitude diagrams (CMDs) are presented for the Spitzer SAGE (Surveying the Agents of a Galaxy's Evolution) survey of the Large Magellanic Cloud (LMC). IRAC and MIPS 24 mu m epoch 1 data are presented. These data represent the deepest, widest mid-infrared CMDs of their kind ever produced in

  19. Antioxidant activity and sensory analysis of a rosmarinic acid-enriched extract of garden sage (Salvia officinalis)

    Science.gov (United States)

    A novel extract of S. officinalis (garden sage) was prepared using supercritical carbon dioxide (SC-CO2) extraction, followed by a Soxhlet hot water extraction. The resulting extract was enriched in polyphenols, including rosmarinic acid (RA), which has shown promising health benefits in animals. Th...

  20. OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia

    DEFF Research Database (Denmark)

    Lim, Jasmine; Goriely, Anne; Turner, Gareth Dh

    2011-01-01

    in the normal adult testis. We analysed the expression pattern of OCT2, SSX2-4, and SAGE1 in 36 SS cases and four intratubular SS (ISS) as well as a series of normal testis samples throughout development. We describe for the first time two different types of SS characterized by OCT2 or SSX2-4 immunoexpression......, whilst SAGE1 was exclusively present in a subset of post-pubertal germ cells, most likely B spermatogonia. The presence of OCT2 and SSX2-4 in distinct subsets of germ cells implies that these markers represent germ cells at different maturation stages. Analysis of SAGE1 and SSX2-4 in ISS showed spatial...... differences suggesting ongoing maturation of germ cells during progression of SS tumourigenesis. We conclude that the expression pattern of OCT2, SSX2-4, and SAGE1 supports the origin of SS from spermatogonia and provides new evidence for heterogeneity of this tumour, potentially linked either to the cellular...

  1. Deformable image registration using convolutional neural networks

    Science.gov (United States)

    Eppenhof, Koen A. J.; Lafarge, Maxime W.; Moeskops, Pim; Veta, Mitko; Pluim, Josien P. W.

    2018-03-01

    Deformable image registration can be time-consuming and often needs extensive parameterization to perform well on a specific application. We present a step towards a registration framework based on a three-dimensional convolutional neural network. The network directly learns transformations between pairs of three-dimensional images. The outputs of the network are three maps for the x, y, and z components of a thin plate spline transformation grid. The network is trained on synthetic random transformations, which are applied to a small set of representative images for the desired application. Training therefore does not require manually annotated ground truth deformation information. The methodology is demonstrated on public data sets of inspiration-expiration lung CT image pairs, which come with annotated corresponding landmarks for evaluation of the registration accuracy. Advantages of this methodology are its fast registration times and its minimal parameterization.

  2. Playing with labour: the labour registration game

    NARCIS (Netherlands)

    Leesberg, J.; Valencia, E.

    1992-01-01

    Description of a method to register labour allocation patterns of small-scale producer families through a self-registration 'game'. Division of tasks between men and women become visible through this method

  3. 27 CFR 53.140 - Registration.

    Science.gov (United States)

    2010-04-01

    ... of selling or purchasing articles tax free as provided in this section. In the case of a nonprofit....141. (e) Cross references. (1) For exceptions to the requirement for registration, see section 4222(b...

  4. Biometric Authorization and Registration Systems and Methods

    National Research Council Canada - National Science Library

    Caulfield, H

    2002-01-01

    Biometric authorization and registration systems and methods are disclosed. In one embodiment, the system preferably comprises a firearm that includes a biometric authorization system, a plurality of training computers, and a server...

  5. Image Registration Using Redundant Wavelet Transforms

    National Research Council Canada - National Science Library

    Brown, Richard

    2001-01-01

    .... In our research, we present a fundamentally new wavelet-based registration algorithm utilizing redundant transforms and a masking process to suppress the adverse effects of noise and improve processing efficiency...

  6. Modeling ecological minimum requirements for distribution of greater sage-grouse leks: implications for population connectivity across their western range, U.S.A.

    Science.gov (United States)

    Knick, Steven T; Hanser, Steven E; Preston, Kristine L

    2013-06-01

    Greater sage-grouse Centrocercus urophasianus (Bonaparte) currently occupy approximately half of their historical distribution across western North America. Sage-grouse are a candidate for endangered species listing due to habitat and population fragmentation coupled with inadequate regulation to control development in critical areas. Conservation planning would benefit from accurate maps delineating required habitats and movement corridors. However, developing a species distribution model that incorporates the diversity of habitats used by sage-grouse across their widespread distribution has statistical and logistical challenges. We first identified the ecological minimums limiting sage-grouse, mapped similarity to the multivariate set of minimums, and delineated connectivity across a 920,000 km(2) region. We partitioned a Mahalanobis D (2) model of habitat use into k separate additive components each representing independent combinations of species-habitat relationships to identify the ecological minimums required by sage-grouse. We constructed the model from abiotic, land cover, and anthropogenic variables measured at leks (breeding) and surrounding areas within 5 km. We evaluated model partitions using a random subset of leks and historic locations and selected D (2) (k = 10) for mapping a habitat similarity index (HSI). Finally, we delineated connectivity by converting the mapped HSI to a resistance surface. Sage-grouse required sagebrush-dominated landscapes containing minimal levels of human land use. Sage-grouse used relatively arid regions characterized by shallow slopes, even terrain, and low amounts of forest, grassland, and agriculture in the surrounding landscape. Most populations were interconnected although several outlying populations were isolated because of distance or lack of habitat corridors for exchange. Land management agencies currently are revising land-use plans and designating critical habitat to conserve sage-grouse and avoid endangered

  7. Modeling ecological minimum requirements for distribution of greater sage-grouse leks: implications for population connectivity across their western range, U.S.A.

    Science.gov (United States)

    Knick, Steven T.; Hanser, Steven E.; Preston, Kristine L.

    2013-01-01

    Greater sage-grouse Centrocercus urophasianus (Bonaparte) currently occupy approximately half of their historical distribution across western North America. Sage-grouse are a candidate for endangered species listing due to habitat and population fragmentation coupled with inadequate regulation to control development in critical areas. Conservation planning would benefit from accurate maps delineating required habitats and movement corridors. However, developing a species distribution model that incorporates the diversity of habitats used by sage-grouse across their widespread distribution has statistical and logistical challenges. We first identified the ecological minimums limiting sage-grouse, mapped similarity to the multivariate set of minimums, and delineated connectivity across a 920,000 km2 region. We partitioned a Mahalanobis D2 model of habitat use into k separate additive components each representing independent combinations of species–habitat relationships to identify the ecological minimums required by sage-grouse. We constructed the model from abiotic, land cover, and anthropogenic variables measured at leks (breeding) and surrounding areas within 5 km. We evaluated model partitions using a random subset of leks and historic locations and selected D2 (k = 10) for mapping a habitat similarity index (HSI). Finally, we delineated connectivity by converting the mapped HSI to a resistance surface. Sage-grouse required sagebrush-dominated landscapes containing minimal levels of human land use. Sage-grouse used relatively arid regions characterized by shallow slopes, even terrain, and low amounts of forest, grassland, and agriculture in the surrounding landscape. Most populations were interconnected although several outlying populations were isolated because of distance or lack of habitat corridors for exchange. Land management agencies currently are revising land-use plans and designating critical habitat to conserve sage-grouse and avoid endangered

  8. Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.

    Directory of Open Access Journals (Sweden)

    Stühlinger Wolf

    2011-07-01

    Full Text Available Abstract Background The sage plant Salvia officinalis L. is used as ingredient in foods and beverages as well as in herbal medicinal products. A major use is in the form of aqueous infusions as sage tea, which is legal to be sold as either food or medicine. Sage may contain two health relevant substances, thujone and camphor. The aim of this study was to develop and validate an analytical methodology to determine these active principles of sage and give a first overview of their concentrations in a wide variety of sage foods and medicines. Results A GC/MS procedure was applied for the analysis of α- and β-thujone and camphor with cyclodecanone as internal standard. The precision was between 0.8 and 12.6%, linearity was obtained from 0.1 - 80 mg/L. The recoveries of spiked samples were between 93.7 and 104.0% (average 99.1%. The time of infusion had a considerable influence on the content of analytes found in the teas. During the brewing time, thujone and camphor show an increase up to about 5 min, after which saturation is reached. No effect was found for preparation with or without a lid on the pot used for brewing the infusion. Compared to extracts with ethanol (60% vol, which provide a maximum yield, an average of 30% thujone are recovered in the aqueous tea preparations. The average thujone and camphor contents were 4.4 mg/L and 16.7 mg/L in food tea infusions and 11.3 mg/L and 25.4 mg/L in medicinal tea infusions. Conclusions The developed methodology allows the efficient determination of thujone and camphor in a wide variety of sage food and medicine matrices and can be applied to conduct surveys for exposure assessment. The current results suggest that on average between 3 and 6 cups of sage tea could be daily consumed without reaching toxicological thresholds.

  9. Interseasonal movements of greater sage-grouse, migratory behavior, and an assessment of the core regions concept in Wyoming

    Science.gov (United States)

    Fedy, Bradley C.; Aldridge, Cameron L.; Doherty, Kevin E.; O'Donnell, Michael S.; Beck, Jeffrey L.; Bedrosian, Bryan; Holloran, Matthew J.; Johnson, Gregory D.; Kaczor, Nicholas W.; Kirol, Christopher P.; Mandich, Cheryl A.; Marshall, David; McKee, Gwyn; Olson, Chad; Swanson, Christopher C.; Walker, Brett L.

    2012-01-01

    Animals can require different habitat types throughout their annual cycles. When considering habitat prioritization, we need to explicitly consider habitat requirements throughout the annual cycle, particularly for species of conservation concern. Understanding annual habitat requirements begins with quantifying how far individuals move across landscapes between key life stages to access required habitats. We quantified individual interseasonal movements for greater sage-grouse (Centrocercus urophasianus; hereafter sage-grouse) using radio-telemetry spanning the majority of the species distribution in Wyoming. Sage-grouse are currently a candidate for listing under the United States Endangered Species Act and Wyoming is predicted to remain a stronghold for the species. Sage-grouse use distinct seasonal habitats throughout their annual cycle for breeding, brood rearing, and wintering. Average movement distances in Wyoming from nest sites to summer-late brood-rearing locations were 8.1 km (SE = 0.3 km; n = 828 individuals) and the average subsequent distances moved from summer sites to winter locations were 17.3 km (SE = 0.5 km; n = 607 individuals). Average nest-to-winter movements were 14.4 km (SE = 0.6 km; n = 434 individuals). We documented remarkable variation in the extent of movement distances both within and among sites across Wyoming, with some individuals remaining year-round in the same vicinity and others moving over 50 km between life stages. Our results suggest defining any of our populations as migratory or non-migratory is innappropriate as individual strategies vary widely. We compared movement distances of birds marked using Global Positioning System (GPS) and very high frequency (VHF) radio marking techniques and found no evidence that the heavier GPS radios limited movement. Furthermore, we examined the capacity of the sage-grouse core regions concept to capture seasonal locations. As expected, we found the core regions approach, which was

  10. Summary of science, activities, programs, and policies that influence the rangewide conservation of Greater Sage-Grouse (Centrocercus urophasianus)

    Science.gov (United States)

    Manier, D.J.; Wood, David J.A.; Bowen, Z.H.; Donovan, R.M.; Holloran, M.J.; Juliusson, L.M.; Mayne, K.S.; Oyler-McCance, S.J.; Quamen, F.R.; Saher, D.J.; Titolo, A.J.

    2013-01-01

    The Greater Sage-Grouse, has been observed, hunted, and counted for decades. The sagebrush biome, home to the Greater Sage-Grouse, includes sagebrush-steppe and Great Basin sagebrush communities, interspersed with grasslands, salt flats, badlands, mountain ranges, springs, intermittent creeks and washes, and major river systems, and is one of the most widespread and enigmatic components of Western U.S. landscapes. Over time, habitat conversion, degradation, and fragmentation have accumulated across the entire range such that local conditions as well as habitat distributions at local and regional scales are negatively affecting the long-term persistence of this species. Historic patterns of human use and settlement of the sagebrush ecosystem have contributed to the current condition and status of sage-grouse populations. The accumulation of habitat loss, persistent habitat degradation, and fragmentation by industry and urban infrastructure, as indicated by U.S. Fish and Wildlife Service (USFWS) findings, presents a significant challenge for conservation of this species and sustainable management of the sagebrush ecosystem. Because of the wide variations in natural and human history across these landscapes, no single prescription for management of sagebrush ecosystems (including sage-grouse habitats) will suffice to guide the collective efforts of public and private entities to conserve the species and its habitat. This report documents and summarizes several decades of work on sage-grouse populations, sagebrush as habitat, and sagebrush community and ecosystem functions based on the recent assessment and findings of the USFWS under consideration of the Endangered Species Act. As reflected here, some of these topics receive a greater depth of discussion because of the perceived importance of the issue for sagebrush ecosystems and sage-grouse populations. Drawing connections between the direct effects on sagebrush ecosystems and the effect of ecosystem condition on

  11. A conservation planning tool for Greater Sage-grouse using indices of species distribution, resilience, and resistance.

    Science.gov (United States)

    Ricca, Mark A; Coates, Peter S; Gustafson, K Benjamin; Brussee, Brianne E; Chambers, Jeanne C; Espinosa, Shawn P; Gardner, Scott C; Lisius, Sherri; Ziegler, Pilar; Delehanty, David J; Casazza, Michael L

    2018-06-01

    Managers require quantitative yet tractable tools that identify areas for restoration yielding effective benefits for targeted wildlife species and the ecosystems they inhabit. As a contemporary example of high national significance for conservation, the persistence of Greater Sage-grouse (Centrocercus urophasianus) in the Great Basin is compromised by strongly interacting stressors of conifer expansion, annual grass invasion, and more frequent wildfires occurring in sagebrush ecosystems. Associated restoration treatments to a sagebrush-dominated state are often costly and may yield relatively little ecological benefit to sage-grouse if implemented without estimating how Sage-grouse may respond to treatments, or do not consider underlying processes influencing sagebrush ecosystem resilience to disturbance and resistance to invasive species. Here, we describe example applications of a spatially explicit conservation planning tool (CPT) to inform prioritization of: (1) removal of conifers (i.e., pinyon-juniper); and (2) wildfire restoration aimed at improving habitat conditions for the Bi-State Distinct Population Segment of Sage-grouse along the California-Nevada state line. The CPT measures ecological benefits to sage-grouse for a given management action through a composite index comprised of resource selection functions and estimates of abundance and space use. For pinyon-juniper removal, we simulated changes in land-cover composition following the removal of sparse trees with intact understories, and ranked treatments on the basis of changes in ecological benefits per dollar-unit of cost. For wildfire restoration, we formulated a conditional model to simulate scenarios for land cover changes (e.g., sagebrush to annual grass) given estimated fire severity and underlying ecosystem processes influencing resilience to disturbance and resistance to invasion by annual grasses. For both applications, we compared CPT rankings to land cover changes along with sagebrush

  12. 12 CFR 584.2-2 - Permissible bank holding company activities of savings and loan holding companies.

    Science.gov (United States)

    2010-01-01

    ... savings and loan holding companies. 584.2-2 Section 584.2-2 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SAVINGS AND LOAN HOLDING COMPANIES § 584.2-2 Permissible bank holding company activities of savings and loan holding companies. (a) General. For purposes of § 584.2(b)(6)(i) of this part...

  13. 12 CFR 225.82 - How does a bank holding company elect to become a financial holding company?

    Science.gov (United States)

    2010-01-01

    ... holding company to become a financial holding company shall not be effective if, during the period...) Effective date of election—(1) In general. An election filed by a bank holding company under paragraph (a... financial holding company is effective prior to the 31st day after the date that a complete declaration was...

  14. An image acquisition and registration strategy for the fusion of hyperpolarized helium-3 MRI and x-ray CT images of the lung

    Science.gov (United States)

    Ireland, Rob H.; Woodhouse, Neil; Hoggard, Nigel; Swinscoe, James A.; Foran, Bernadette H.; Hatton, Matthew Q.; Wild, Jim M.

    2008-11-01

    The purpose of this ethics committee approved prospective study was to evaluate an image acquisition and registration protocol for hyperpolarized helium-3 magnetic resonance imaging (3He-MRI) and x-ray computed tomography. Nine patients with non-small cell lung cancer (NSCLC) gave written informed consent to undergo a free-breathing CT, an inspiration breath-hold CT and a 3D ventilation 3He-MRI in CT position using an elliptical birdcage radiofrequency (RF) body coil. 3He-MRI to CT image fusion was performed using a rigid registration algorithm which was assessed by two observers using anatomical landmarks and a percentage volume overlap coefficient. Registration of 3He-MRI to breath-hold CT was more accurate than to free-breathing CT; overlap 82.9 ± 4.2% versus 59.8 ± 9.0% (p < 0.001) and mean landmark error 0.75 ± 0.24 cm versus 1.25 ± 0.60 cm (p = 0.002). Image registration is significantly improved by using an imaging protocol that enables both 3He-MRI and CT to be acquired with similar breath holds and body position through the use of a birdcage 3He-MRI body RF coil and an inspiration breath-hold CT. Fusion of 3He-MRI to CT may be useful for the assessment of patients with lung diseases.

  15. 17 CFR 239.33 - Form F-3, for registration under the Securities Act of 1933 of securities of certain foreign...

    Science.gov (United States)

    2010-04-01

    ... holding company and that the assets and liabilities of the successor at the time of succession were... Commission and posted on its corporate Web site, if any, all Interactive Data Files required to be submitted...) Primary offerings by certain registrants. Securities to be offered for cash by or on behalf of a...

  16. A SAGE based approach to human glomerular endothelium: defining the transcriptome, finding a novel molecule and highlighting endothelial diversity.

    Science.gov (United States)

    Sengoelge, Guerkan; Winnicki, Wolfgang; Kupczok, Anne; von Haeseler, Arndt; Schuster, Michael; Pfaller, Walter; Jennings, Paul; Weltermann, Ansgar; Blake, Sophia; Sunder-Plassmann, Gere

    2014-08-27

    Large scale transcript analysis of human glomerular microvascular endothelial cells (HGMEC) has never been accomplished. We designed this study to define the transcriptome of HGMEC and facilitate a better characterization of these endothelial cells with unique features. Serial analysis of gene expression (SAGE) was used for its unbiased approach to quantitative acquisition of transcripts. We generated a HGMEC SAGE library consisting of 68,987 transcript tags. Then taking advantage of large public databases and advanced bioinformatics we compared the HGMEC SAGE library with a SAGE library of non-cultured ex vivo human glomeruli (44,334 tags) which contained endothelial cells. The 823 tags common to both which would have the potential to be expressed in vivo were subsequently checked against 822,008 tags from 16 non-glomerular endothelial SAGE libraries. This resulted in 268 transcript tags differentially overexpressed in HGMEC compared to non-glomerular endothelia. These tags were filtered using a set of criteria: never before shown in kidney or any type of endothelial cell, absent in all nephron regions except the glomerulus, more highly expressed than statistically expected in HGMEC. Neurogranin, a direct target of thyroid hormone action which had been thought to be brain specific and never shown in endothelial cells before, fulfilled these criteria. Its expression in glomerular endothelium in vitro and in vivo was then verified by real-time-PCR, sequencing and immunohistochemistry. Our results represent an extensive molecular characterization of HGMEC beyond a mere database, underline the endothelial heterogeneity, and propose neurogranin as a potential link in the kidney-thyroid axis.

  17. Seasonal Habitat Use by Greater Sage-Grouse (Centrocercus urophasianus) on a Landscape with Low Density Oil and Gas Development.

    Science.gov (United States)

    Rice, Mindy B; Rossi, Liza G; Apa, Anthony D

    2016-01-01

    Fragmentation of the sagebrush (Artemisia spp.) ecosystem has led to concern about a variety of sagebrush obligates including the greater sage-grouse (Centrocercus urophasianus). Given the increase of energy development within greater sage-grouse habitats, mapping seasonal habitats in pre-development populations is critical. The North Park population in Colorado is one of the largest and most stable in the state and provides a unique case study for investigating resource selection at a relatively low level of energy development compared to other populations both within and outside the state. We used locations from 117 radio-marked female greater sage-grouse in North Park, Colorado to develop seasonal resource selection models. We then added energy development variables to the base models at both a landscape and local scale to determine if energy variables improved the fit of the seasonal models. The base models for breeding and winter resource selection predicted greater use in large expanses of sagebrush whereas the base summer model predicted greater use along the edge of riparian areas. Energy development variables did not improve the winter or the summer models at either scale of analysis, but distance to oil/gas roads slightly improved model fit at both scales in the breeding season, albeit in opposite ways. At the landscape scale, greater sage-grouse were closer to oil/gas roads whereas they were further from oil/gas roads at the local scale during the breeding season. Although we found limited effects from low level energy development in the breeding season, the scale of analysis can influence the interpretation of effects. The lack of strong effects from energy development may be indicative that energy development at current levels are not impacting greater sage-grouse in North Park. Our baseline seasonal resource selection maps can be used for conservation to help identify ways of minimizing the effects of energy development.

  18. Non-target effects on songbirds from habitat manipulation for Greater Sage-Grouse: Implications for the umbrella species concept

    Science.gov (United States)

    Carlisle, Jason D.; Chalfoun, Anna D.; Smith, Kurt T.; Beck, Jeffery L.

    2018-01-01

    The “umbrella species” concept is a conservation strategy in which creating and managing reserve areas to meet the needs of one species is thought to benefit other species indirectly. Broad-scale habitat protections on behalf of an umbrella species are assumed to benefit co-occurring taxa, but targeted management actions to improve local habitat suitability for the umbrella species may produce unintended effects on other species. Our objective was to quantify the effects of a common habitat treatment (mowing of big sagebrush [Artemisia tridentata]) intended to benefit a high-profile umbrella species (Greater Sage-Grouse [Centrocercus urophasianus]) on 3 sympatric songbird species of concern. We used a before–after control-impact experimental design spanning 3 yr in Wyoming, USA, to quantify the effect of mowing on the abundance, nest-site selection, nestling condition, and nest survival of 2 sagebrush-obligate songbirds (Brewer's Sparrow [Spizella breweri] and Sage Thrasher [Oreoscoptes montanus]) and one open-habitat generalist songbird (Vesper Sparrow [Pooecetes gramineus]). Mowing was associated with lower abundance of Brewer's Sparrows and Sage Thrashers but higher abundance of Vesper Sparrows. We found no Brewer's Sparrows or Sage Thrashers nesting in the mowed footprint posttreatment, which suggests complete loss of nesting habitat for these species. Mowing was associated with higher nestling condition and nest survival for Vesper Sparrows but not for the sagebrush-obligate species. Management prescriptions that remove woody biomass within a mosaic of intact habitat may be tolerated by sagebrush-obligate songbirds but are likely more beneficial for open-habitat generalist species. By definition, umbrella species conservation entails habitat protections at broad spatial scales. We caution that habitat manipulations to benefit Greater Sage-Grouse could negatively affect nontarget species of conservation concern if implemented across large spatial extents.

  19. Evaluation of the genetic distinctiveness of Greater Sage-grouse in the Bi-State Planning Area

    Science.gov (United States)

    Oyler-McCance, Sara J.; Casazza, Michael L.

    2011-01-01

    The purpose of this study was to further characterize a distinct population of Greater Sage-grouse: the population located along the border between Nevada and California (Bi-State Planning Area) and centered around the Mono Basin. This population was previously determined to be genetically distinct from other Greater Sage-grouse populations across their range. Previous genetic work focused on characterizing genetic variation across the species' range and thereby used a coarse sampling approach for species characterization. The goal of this study was to investigate this population further by obtaining samples from breeding locations within the population and analyzing those samples with the same mitochondrial and microsatellite loci used in previous studies. Blood samples were collected in six locations within the Bi-State Planning Area. Genetic data from subpopulations were then compared with each other and also with two populations outside of the Bi-State Planning Area. Particular attention was paid to subpopulation boundaries and internal dynamics by drawing comparisons among particular regions within the Bi-State Planning Area and regions proximal to it. All newly sampled subpopulations contained mitochondrial haplotypes and allele frequencies that were consistent with the genetically unique Bi-State (Mono Basin) Greater Sage-grouse described previously. This reinforces the fact that this group of Greater Sage-grouse is genetically unique and warrants special attention. Maintaining the genetic integrity of this population could protect the evolutionary potential of this population of Greater Sage-grouse. Additionally, the White Mountains subpopulation was found to be significantly distinct from all other Bi-State subpopulations.

  20. 46 CFR 402.220 - Registration of pilots.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Registration of pilots. 402.220 Section 402.220 Shipping... ORDERS Registration of Pilots § 402.220 Registration of pilots. (a) Each applicant pilot must complete the number of round trips specified in this section prior to registration as a U.S. registered pilot...

  1. TU-B-19A-01: Image Registration II: TG132-Quality Assurance for Image Registration

    International Nuclear Information System (INIS)

    Brock, K; Mutic, S

    2014-01-01

    AAPM Task Group 132 was charged with a review of the current approaches and solutions for image registration in radiotherapy and to provide recommendations for quality assurance and quality control of these clinical processes. As the results of image registration are always used as the input of another process for planning or delivery, it is important for the user to understand and document the uncertainty associate with the algorithm in general and the Result of a specific registration. The recommendations of this task group, which at the time of abstract submission are currently being reviewed by the AAPM, include the following components. The user should understand the basic image registration techniques and methods of visualizing image fusion. The disclosure of basic components of the image registration by commercial vendors is critical in this respect. The physicists should perform end-to-end tests of imaging, registration, and planning/treatment systems if image registration is performed on a stand-alone system. A comprehensive commissioning process should be performed and documented by the physicist prior to clinical use of the system. As documentation is important to the safe implementation of this process, a request and report system should be integrated into the clinical workflow. Finally, a patient specific QA practice should be established for efficient evaluation of image registration results. The implementation of these recommendations will be described and illustrated during this educational session. Learning Objectives: Highlight the importance of understanding the image registration techniques used in their clinic. Describe the end-to-end tests needed for stand-alone registration systems. Illustrate a comprehensive commissioning program using both phantom data and clinical images. Describe a request and report system to ensure communication and documentation. Demonstrate an clinically-efficient patient QA practice for efficient evaluation of image

  2. Incorporation of a laser range scanner into image-guided liver surgery: Surface acquisition, registration, and tracking

    OpenAIRE

    Cash, David M.; Sinha, Tuhin K.; Chapman, William C.; Terawaki, Hiromi; Dawant, Benoit M.; Galloway, Robert L.; Miga, Michael I.

    2003-01-01

    As image guided surgical procedures become increasingly diverse, there will be more scenarios where point-based fiducials cannot be accurately localized for registration and rigid body assumptions no longer hold. As a result, procedures will rely more frequently on anatomical surfaces for the basis of image alignment and will require intraoperative geometric data to measure and compensate for tissue deformation in the organ. In this paper we outline methods for which a laser range scanner may...

  3. A small animal holding fixture system with positional reproducibility for longitudinal multimodal imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kokuryo, Daisuke; Kimura, Yuichi; Obata, Takayuki; Yamaya, Taiga; Kawamura, Kazunori; Zhang, Ming-Rong; Kanno, Iwao; Aoki, Ichio, E-mail: ukimura@ieee.or [Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage, Chiba 263-8555 (Japan)

    2010-07-21

    This study presents a combined small animal holding fixture system, termed a 'bridge capsule', which provides for small animal re-fixation with positional reproducibility. This system comprises separate holding fixtures for the head and lower body and a connecting part to a gas anesthesia system. A mouse is fixed in place by the combination of a head fixture with a movable part made from polyacetal resin, a lower body fixture made from vinyl-silicone and a holder for the legs and tail. For re-fixation, a similar posture could be maintained by the same holding fixtures and a constant distance between the head and lower body fixtures is maintained. Artifacts caused by the bridge capsule system were not observed on magnetic resonance (MRI) and positron emission tomography (PET) images. The average position differences of the spinal column and the iliac body before and after re-fixation for the same modality were approximately 1.1 mm. The difference between the MRI and PET images was approximately 1.8 mm for the lower body fixture after image registration using fiducial markers. This system would be useful for longitudinal, repeated and multimodal imaging experiments requiring similar animal postures.

  4. A conceptual holding model for veterinary applications

    Directory of Open Access Journals (Sweden)

    Nicola Ferrè

    2014-05-01

    Full Text Available Spatial references are required when geographical information systems (GIS are used for the collection, storage and management of data. In the veterinary domain, the spatial component of a holding (of animals is usually defined by coordinates, and no other relevant information needs to be interpreted or used for manipulation of the data in the GIS environment provided. Users trying to integrate or reuse spatial data organised in such a way, frequently face the problem of data incompatibility and inconsistency. The root of the problem lies in differences with respect to syntax as well as variations in the semantic, spatial and temporal representations of the geographic features. To overcome these problems and to facilitate the inter-operability of different GIS, spatial data must be defined according to a “schema” that includes the definition, acquisition, analysis, access, presentation and transfer of such data between different users and systems. We propose an application “schema” of holdings for GIS applications in the veterinary domain according to the European directive framework (directive 2007/2/EC - INSPIRE. The conceptual model put forward has been developed at two specific levels to produce the essential and the abstract model, respectively. The former establishes the conceptual linkage of the system design to the real world, while the latter describes how the system or software works. The result is an application “schema” that formalises and unifies the information-theoretic foundations of how to spatially represent a holding in order to ensure straightforward information-sharing within the veterinary community.

  5. A mathematical model of aerosol holding chambers

    DEFF Research Database (Denmark)

    Zak, M; Madsen, J; Berg, E

    1999-01-01

    A mathematical model of aerosol delivery from holding chambers (spacers) was developed incorporating tidal volume (VT), chamber volume (Vch), apparatus dead space (VD), effect of valve insufficiency and other leaks, loss of aerosol by immediate impact on the chamber wall, and fallout of aerosol...... in the chamber with time. Four different spacers were connected via filters to a mechanical lung model, and aerosol delivery during "breathing" was determined from drug recovery from the filters. The formula correctly predicted the delivery of budesonide aerosol from the AeroChamber (Trudell Medical, London...

  6. The Economics of an Admissions Holding Unit.

    Science.gov (United States)

    Schreyer, Kraftin E; Martin, Richard

    2017-06-01

    With increasing attention to the actual cost of delivering care, return-on-investment calculations take on new significance. Boarded patients in the emergency department (ED) are harmful to clinical care and have significant financial opportunity costs. We hypothesize that investment in an admissions holding unit for admitted ED patients not only captures opportunity cost but also significantly lowers direct cost of care. This was a three-phase study at a busy urban teaching center with significant walkout rate. We first determined the true cost of maintaining a staffed ED bed for one patient-hour and compared it to alternative settings. The opportunity cost for patients leaving without being seen was then conservatively estimated. Lastly, a convenience sample of admitted patients boarding in the ED was observed continuously from one hour after decision-to-admit until physical departure from the ED to capture a record of every interaction with a nurse or physician. Personnel costs per patient bed-hour were $58.20 for the ED, $24.80 for an inpatient floor, $19.20 for the inpatient observation unit, and $10.40 for an admissions holding area. An eight-bed holding unit operating at practical capacity would free 57.4 hours of bed space in the ED and allow treatment of 20 additional patients. This could yield increased revenues of $27,796 per day and capture opportunity cost of $6.09 million over 219 days, in return for extra staffing costs of $218,650. Analysis of resources used for boarded patients was determined by continuous observation of a convenience sample of ED-boarded patients, which found near-zero interactions with both nursing and physicians during the boarding interval. Resource expense per ED bed-hour is more than twice that in non-critical care inpatient units. Despite the high cost of available resources, boarded non-critical patients receive virtually no nursing or physician attention. An admissions holding unit is remarkably effective in avoiding the

  7. Hold-down device for nuclear reactor

    International Nuclear Information System (INIS)

    Leclercq, J.; Bonnamour, M.

    1984-01-01

    The present device can be used in nuclear reactors and more particularly in pressurized water reactors consisting of coupled fuel assemblies, certain of which are equipped with non-displaceable elements carried by an unsertable member. The device comprises the unsertable member provided with at least two sets of springs which transmit the load of an upper structure common to the fuel assemblies ajacent that which supports the unsertable member. The device is used to hold-down fuel assemblies which are subjected to the forces of circulating coolant [fr

  8. The Economics of an Admissions Holding Unit

    Directory of Open Access Journals (Sweden)

    Kraftin E. Schreyer

    2017-05-01

    Full Text Available Introduction: With increasing attention to the actual cost of delivering care, return-on-investment calculations take on new significance. Boarded patients in the emergency department (ED are harmful to clinical care and have significant financial opportunity costs. We hypothesize that investment in an admissions holding unit for admitted ED patients not only captures opportunity cost but also significantly lowers direct cost of care. Methods: This was a three-phase study at a busy urban teaching center with significant walkout rate. We first determined the true cost of maintaining a staffed ED bed for one patient-hour and compared it to alternative settings. The opportunity cost for patients leaving without being seen was then conservatively estimated. Lastly, a convenience sample of admitted patients boarding in the ED was observed continuously from one hour after decision-to-admit until physical departure from the ED to capture a record of every interaction with a nurse or physician. Results: Personnel costs per patient bed-hour were $58.20 for the ED, $24.80 for an inpatient floor, $19.20 for the inpatient observation unit, and $10.40 for an admissions holding area. An eight-bed holding unit operating at practical capacity would free 57.4 hours of bed space in the ED and allow treatment of 20 additional patients. This could yield increased revenues of $27,796 per day and capture opportunity cost of $6.09 million over 219 days, in return for extra staffing costs of $218,650. Analysis of resources used for boarded patients was determined by continuous observation of a convenience sample of ED-boarded patients, which found near-zero interactions with both nursing and physicians during the boarding interval. Conclusion: Resource expense per ED bed-hour is more than twice that in non-critical care inpatient units. Despite the high cost of available resources, boarded non-critical patients receive virtually no nursing or physician attention. An

  9. MIM Holdings Limited 1984 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    M.I.M. Holdings Limited is a major mining and mineral processing company formed in 1970. The group traces its origins to 1924 following the discovery of silver lead zinc started in 1931 and parallel production of silver lead zinc ore at Mount Isa the previous year. Today the MIM group is a diversified mineral, coal and metal producing and marketing organisation. Details of the company's principal activities over the last year, and accounts and management information for the last year are presented.

  10. Household characteristics for older adults and study background from SAGE Ghana Wave 1

    Directory of Open Access Journals (Sweden)

    Richard B. Biritwum

    2013-06-01

    Full Text Available Background: Globally, the population aged 60 years and older is projected to reach 22% by 2050. In sub-Saharan Africa, this figure is projected to exceed 8%, while in Ghana, the older adult population will reach 12% by 2050. The living arrangements and household characteristics are fundamental determinants of the health and well-being of this population, data sources about which are increasingly available. Methods: The World Health Organization's Study on global AGEing and adult health (SAGE Wave 1 was conducted in China, Ghana, India, Russian Federation, Mexico, and South Africa between 2007 and 2010. SAGE Ghana Wave 1 was implemented in 2007/08 using face-to-face interviews in a nationally representative sample of persons aged 50-plus, along with a smaller cohort aged 18–49 years for comparison purposes. Household information included a household roster including questions about health insurance coverage for all household members, household and sociodemographic characteristics, status of the dwelling, and economic situation. Re-interviews were done in a random 10% of the sample and proxy interviews done where necessary. Verbal autopsies were conducted for deaths occurring in older adult household members in the 24 months prior to interview. Results: The total household population was 27,270 from 5,178 households. The overall household response rate was 86% and household cooperation rate was 98%. Thirty-four percent of household members were under 15 years of age while 8.3% were aged 65-plus years. Households with more than 11 members were more common in rural areas (57.2% and in the highest income quintile (30.6%. Household members with no formal education formed 24.7% of the sample, with Northern and Upper East regions reaching more than 50%. Only 26.8% of the household members had insurance coverage. Households with hard floors ranged from 25.7% in Upper West to 97.7% in Ashanti region. Overall, 84.9% of the households had access to

  11. Household characteristics for older adults and study background from SAGE Ghana Wave 1.

    Science.gov (United States)

    Biritwum, Richard B; Mensah, George; Minicuci, Nadia; Yawson, Alfred E; Naidoo, Nirmala; Chatterji, Somnath; Kowal, Paul

    2013-06-11

    Globally, the population aged 60 years and older is projected to reach 22% by 2050. In sub-Saharan Africa, this figure is projected to exceed 8%, while in Ghana, the older adult population will reach 12% by 2050. The living arrangements and household characteristics are fundamental determinants of the health and well-being of this population, data sources about which are increasingly available. The World Health Organization's Study on global AGEing and adult health (SAGE) Wave 1 was conducted in China, Ghana, India, Russian Federation, Mexico, and South Africa between 2007 and 2010. SAGE Ghana Wave 1 was implemented in 2007/08 using face-to-face interviews in a nationally representative sample of persons aged 50-plus, along with a smaller cohort aged 18-49 years for comparison purposes. Household information included a household roster including questions about health insurance coverage for all household members, household and sociodemographic characteristics, status of the dwelling, and economic situation. Re-interviews were done in a random 10% of the sample and proxy interviews done where necessary. Verbal autopsies were conducted for deaths occurring in older adult household members in the 24 months prior to interview. The total household population was 27,270 from 5,178 households. The overall household response rate was 86% and household cooperation rate was 98%. Thirty-four percent of household members were under 15 years of age while 8.3% were aged 65-plus years. Households with more than 11 members were more common in rural areas (57.2%) and in the highest income quintile (30.6%). Household members with no formal education formed 24.7% of the sample, with Northern and Upper East regions reaching more than 50%. Only 26.8% of the household members had insurance coverage. Households with hard floors ranged from 25.7% in Upper West to 97.7% in Ashanti region. Overall, 84.9% of the households had access to improved sources of drinking water, with the lowest at

  12. Person-centred communication for emotional support in district nursing: SAGE and THYME model.

    Science.gov (United States)

    Griffiths, Jane

    2017-12-02

    Patients on district nursing caseloads have multiple physical morbidities, and related emotional concerns. District nurses are ideally placed to assess and meet patients' emotional needs but in increasingly stretched workplaces, it is difficult to find time. There is also evidence that district nurses sometimes believe they lack skills to address patients' concerns. Traditional communication skills training is useful for encouraging patients to open up about their concerns, but less helpful at finding workable solutions. District nurses can be afraid to open a 'can of worms' of concerns that they are unable to deal with. SAGE and THYME is a person-centred, evidence-based communication skills model that addresses district nurses' concerns about time and skills. It provides a structure for conversations about concerns, and empowers patients to work with district nurses to find solutions. Research suggests that it is a promising model for district nursing practice.

  13. SAGE II Measurements of Stratospheric Aerosol Properties at Non-Volcanic Levels

    Science.gov (United States)

    Thomason, Larry W.; Burton, Sharon P.; Luo, Bei-Ping; Peter, Thomas

    2008-01-01

    Since 2000, stratospheric aerosol levels have been relatively stable and at the lowest levels observed in the historical record. Given the challenges of making satellite measurements of aerosol properties at these levels, we have performed a study of the sensitivity of the product to the major components of the processing algorithm used in the production of SAGE II aerosol extinction measurements and the retrieval process that produces the operational surface area density (SAD) product. We find that the aerosol extinction measurements, particularly at 1020 nm, remain robust and reliable at the observed aerosol levels. On the other hand, during background periods, the SAD operational product has an uncertainty of at least a factor of 2 during due to the lack of sensitivity to particles with radii less than 100 nm.

  14. In-beam study of {sup 253}No using the SAGE spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Mistry, A.K.; Herzberg, R.D.; Butler, P.A.; Cox, D.M.; Joss, D.T.; Page, R.D.; Seddon, D.; Thornhill, J.; Wells, D. [University of Liverpool, Oliver Lodge Laboratory, Liverpool (United Kingdom); Greenlees, P.T.; Papadakis, P.; Auranen, K.; Grahn, T.; Jakobsson, U.; Julin, R.; Konki, J.; Leino, M.; Pakarinen, J.; Peura, P.; Rahkila, P.; Sandzelius, M.; Scholey, C.; Sorri, J.; Stolze, S.; Uusitalo, J. [University of Jyvaskyla, Department of Physics, Jyvaskyla (Finland); Garnsworthy, A.B.; Ketelhut, S. [University of British Columbia, TRIUMF, Vancouver, British Columbia (Canada); Hauschild, K.; Lopez-Martens, A. [Universite Paris-Sud, CSNSM, CNRS, IN2P3, Orsay (France); Simpson, J. [STFC, Daresbury Laboratory, Daresbury, Warrington (United Kingdom)

    2017-02-15

    The heavy actinide nucleus {sup 253}No (Z = 102) was studied using the (S)ilicon (A)nd (Ge)rmanium (SAGE) spectrometer allowing simultaneous in-beam γ-ray and conversion electron spectroscopy at the accelerator laboratory of the University of Jyvaeskylae. Using the recoil-tagging technique, γ-electron coincidences have allowed for the extension of the level scheme in the lower-spin region of the yrast band. In addition, internal conversion coefficient (ICC) measurements to establish the multipolarity of transitions have been performed. Measurement of the interband-intraband branching ratios supports the assignment of the Nilsson band-head configuration 9/2{sup -}[734] assigned in previous studies. The study shows the viability of combined in-beam electron and γ-ray spectroscopy down to μb cross sections. (orig.)

  15. Solar neutrino oscillation parameters after SNO Phase-III and SAGE Part-III

    International Nuclear Information System (INIS)

    Yang Ping; Liu Qiuyu

    2009-01-01

    We analyse the recently published results from solar neutrino experiments SNO Phase-III and SAGE Part-III and show their constraints on solar neutrino oscillation parameters, especially for the mixing angle θ 12 . Through a global analysis using all existing data from SK, SNO, Ga and Cl radiochemical experiments and long base line reactor experiment KamLAND , we obtain the parameters Δm 12 2 =7.684 -0.208 +0.212 x 10 -5 eV 2 , tan 2 θ 12 =0.440 -0.057 +0.059 . We also find that the discrepancy between the KamLAND and solar neutrino results can be reduced by choosing a small non-zero value for the mixing angle θ 13 . (authors)

  16. Breeding of a new scarlet sage variety Shenzhouhong and its identification by SRAP

    International Nuclear Information System (INIS)

    Fu Qiaojuan; Shen Guozheng; Li Chunnan; Cui Hairui

    2012-01-01

    A new scarlet sage (Salvia splendens) variety Shenzhouhong was obtained by several generation selections from the progeny of the variety Diwang carried by the spacecraft Shenzhou No.4 for space mutagenesis. Shenzhouhong was approved to release by Non-major Crop Identification Committee of Zhejiang Province in December 2008. Compared with its original variety Diwang, Shenzhouhong was significantly improved in survival rate, flowering time and ornamental period of single flower branch. SRAP (sequence-related amplified polymorphism) analysis showed that 17 of 33 pairs of primer combinations tested in total were polymorphic and the genetic similarity coefficient between them was 0.945, suggesting that the genetic variation was happened after space mutagenesis. Our results proved that space mutagenesis was a kind of effective breeding approach for Salvia splendens and the SRAP was an efficient method for analysis of space-induced mutations. (authors)

  17. Discovery of a New Wolf-Rayet Star Using SAGE-LMC

    Science.gov (United States)

    Gvaramadze, V. V.; Chené, A.-N.; Kniazev, A. Y.; Schnurr, O.

    2012-12-01

    We report the first-ever discovery of an extragalactic Wolf-Rayet (WR) star with Spitzer. A new WR star in the Large Magellanic Cloud (LMC) was revealed via detection of its circumstellar shell using 24 μm images obtained in the framework of the Spitzer Survey of the Large Magellanic Cloud (SAGE-LMC). Subsequent spectroscopic observations with the Gemini South resolved the central star in two components, one of which is a WN3b+abs star, while the second one is a B0 V star. We consider the lopsided brightness distribution over the circumstellar shell as an indication that the WR star is a runaway and use this interpretation to identify a possible parent cluster of the star.

  18. Chemical composition of sage (Salvia officinalis L. essential oil from the Rio de Janeiro State (Brazil

    Directory of Open Access Journals (Sweden)

    A. Porte

    2013-01-01

    Full Text Available The purpose of this study was to investigate the chemical composition of the essential oil from fresh leaves of sage (Salvia officinalis L. from Petrópolis, Rio de Janeiro State, for international trade. The oil was isolated by hydrodistillation in a Clevenger-type apparatus and analyzed through a combination of GC-FID and GC-MS. The yield was 2.3 % on dry basis. Forty-seven constituents were identified according to their chromatographic retention indices and mass spectra, corresponding to 94.90 % of the compounds present. The major constituents of the oil were α-thujone (40.90 %, camphor (26.12 %, α-pinene (5.85 % and β-thujone (5.62 %. The essential oil studied was similar to those found in several European countries and can be a valuable product for the small farmers from the Petrópolis region in Rio de Janeiro State.

  19. Sage-femme ou gynécologue ? M.-A. Boivin (1773-1841)

    OpenAIRE

    Carol, Anne

    2011-01-01

    Marie-Anne Boivin a été en son temps une des sages-femmes françaises les plus célèbres. Son parcours professionnel et scientifique est présenté ici, illustrant l’espace laissé aux femmes dans les professions médicales. Reconnue d’abord pour ses ouvrages techniques concernant l’obstétrique, elle sort de son champ traditionnel de compétence pour aborder de façon novatrice la gynécologie naissante, à l’instar des médecins, avec son Traité pratique des maladies de l’utérus (1833), devenu un class...

  20. Constrained non-rigid registration for whole body image registration: method and validation

    Science.gov (United States)

    Li, Xia; Yankeelov, Thomas E.; Peterson, Todd E.; Gore, John C.; Dawant, Benoit M.

    2007-03-01

    3D intra- and inter-subject registration of image volumes is important for tasks that include measurements and quantification of temporal/longitudinal changes, atlas-based segmentation, deriving population averages, or voxel and tensor-based morphometry. A number of methods have been proposed to tackle this problem but few of them have focused on the problem of registering whole body image volumes acquired either from humans or small animals. These image volumes typically contain a large number of articulated structures, which makes registration more difficult than the registration of head images, to which the vast majority of registration algorithms have been applied. To solve this problem, we have previously proposed an approach, which initializes an intensity-based non-rigid registration algorithm with a point based registration technique [1, 2]. In this paper, we introduce new constraints into our non-rigid registration algorithm to prevent the bones from being deformed inaccurately. Results we have obtained show that the new constrained algorithm leads to better registration results than the previous one.

  1. Bias correction and Bayesian analysis of aggregate counts in SAGE libraries

    Directory of Open Access Journals (Sweden)

    Briggs William M

    2010-02-01

    Full Text Available Abstract Background Tag-based techniques, such as SAGE, are commonly used to sample the mRNA pool of an organism's transcriptome. Incomplete digestion during the tag formation process may allow for multiple tags to be generated from a given mRNA transcript. The probability of forming a tag varies with its relative location. As a result, the observed tag counts represent a biased sample of the actual transcript pool. In SAGE this bias can be avoided by ignoring all but the 3' most tag but will discard a large fraction of the observed data. Taking this bias into account should allow more of the available data to be used leading to increased statistical power. Results Three new hierarchical models, which directly embed a model for the variation in tag formation probability, are proposed and their associated Bayesian inference algorithms are developed. These models may be applied to libraries at both the tag and aggregate level. Simulation experiments and analysis of real data are used to contrast the accuracy of the various methods. The consequences of tag formation bias are discussed in the context of testing differential expression. A description is given as to how these algorithms can be applied in that context. Conclusions Several Bayesian inference algorithms that account for tag formation effects are compared with the DPB algorithm providing clear evidence of superior performance. The accuracy of inferences when using a particular non-informative prior is found to depend on the expression level of a given gene. The multivariate nature of the approach easily allows both univariate and joint tests of differential expression. Calculations demonstrate the potential for false positive and negative findings due to variation in tag formation probabilities across samples when testing for differential expression.

  2. Combined effects of energy development and disease on greater sage-grouse.

    Directory of Open Access Journals (Sweden)

    Rebecca L Taylor

    Full Text Available Species of conservation concern are increasingly threatened by multiple, anthropogenic stressors which are outside their evolutionary experience. Greater sage-grouse are highly susceptible to the impacts of two such stressors: oil and gas (energy development and West Nile virus (WNv. However, the combined effects of these stressors and their potential interactions have not been quantified. We used lek (breeding ground counts across a landscape encompassing extensive local and regional variation in the intensity of energy development to quantify the effects of energy development on lek counts, in years with widespread WNv outbreaks and in years without widespread outbreaks. We then predicted the effects of well density and WNv outbreak years on sage-grouse in northeast Wyoming. Absent an outbreak year, drilling an undeveloped landscape to a high permitting level (3.1 wells/km² resulted in a 61% reduction in the total number of males counted in northeast Wyoming (total count. This was similar in magnitude to the 55% total count reduction that resulted from an outbreak year alone. However, energy-associated reductions in the total count resulted from a decrease in the mean count at active leks, whereas outbreak-associated reductions resulted from a near doubling of the lek inactivity rate (proportion of leks with a last count = 0. Lek inactivity quadrupled when 3.1 wells/km² was combined with an outbreak year, compared to no energy development and no outbreak. Conservation measures should maintain sagebrush landscapes large and intact enough so that leks are not chronically reduced in size due to energy development, and therefore vulnerable to becoming inactive due to additional stressors.

  3. Tasakaalus tulemuskaardi sage viga on vääralt määratud näitajad / Mait Raava

    Index Scriptorium Estoniae

    Raava, Mait

    2003-01-01

    Tasakaalus tulemuskaart väljendab strateegiliste tulemusnäitajate põhjuslik-tagajärjelisi seoseid, kuid viga tuleb sageli nende tegurite määratlemisel, kirjutab autor. Skeem. Kommenteerib Sven Heil

  4. Quantifying restoration effectiveness using multi-scale habitat models: implications for sage-grouse in the Great Basin

    Science.gov (United States)

    Arkle, Robert S.; Pilliod, David S.; Hanser, Steven E.; Brooks, Matthew L.; Chambers, Jeanne C.; Grace, James B.; Knutson, Kevin C.; Pyke, David A.; Welty, Justin L.

    2014-01-01

    A recurrent challenge in the conservation of wide-ranging, imperiled species is understanding which habitats to protect and whether we are capable of restoring degraded landscapes. For Greater Sage-grouse (Centrocercus urophasianus), a species of conservation concern in the western United States, we approached this problem by developing multi-scale empirical models of occupancy in 211 randomly located plots within a 40 million ha portion of the species' range. We then used these models to predict sage-grouse habitat quality at 826 plots associated with 101 post-wildfire seeding projects implemented from 1990 to 2003. We also compared conditions at restoration sites to published habitat guidelines. Sage-grouse occupancy was positively related to plot- and landscape-level dwarf sagebrush (Artemisia arbuscula, A. nova, A. tripartita) and big sagebrush steppe prevalence, and negatively associated with non-native plants and human development. The predicted probability of sage-grouse occupancy at treated plots was low on average (0.09) and not substantially different from burned areas that had not been treated. Restoration sites with quality habitat tended to occur at higher elevation locations with low annual temperatures, high spring precipitation, and high plant diversity. Of 313 plots seeded after fire, none met all sagebrush guidelines for breeding habitats, but approximately 50% met understory guidelines, particularly for perennial grasses. This pattern was similar for summer habitat. Less than 2% of treated plots met winter habitat guidelines. Restoration actions did not increase the probability of burned areas meeting most guideline criteria. The probability of meeting guidelines was influenced by a latitudinal gradient, climate, and topography. Our results suggest that sage-grouse are relatively unlikely to use many burned areas within 20 years of fire, regardless of treatment. Understory habitat conditions are more likely to be adequate than overstory

  5. Small forest holdings could be combined for hunting leases

    Science.gov (United States)

    John J. Stransky; Lowell K. Halls

    1969-01-01

    Most forest land acreage in the South is in small holdings. Much-needed hunting land, and income for rural landowners, could be provided by combining small forest holdings into large units and teasing the hunting rights.

  6. CT image registration in sinogram space.

    Science.gov (United States)

    Mao, Weihua; Li, Tianfang; Wink, Nicole; Xing, Lei

    2007-09-01

    Object displacement in a CT scan is generally reflected in CT projection data or sinogram. In this work, the direct relationship between object motion and the change of CT projection data (sinogram) is investigated and this knowledge is applied to create a novel algorithm for sinogram registration. Calculated and experimental results demonstrate that the registration technique works well for registering rigid 2D or 3D motion in parallel and fan beam samplings. Problem and solution for 3D sinogram-based registration of metallic fiducials are also addressed. Since the motion is registered before image reconstruction, the presented algorithm is particularly useful when registering images with metal or truncation artifacts. In addition, this algorithm is valuable for dealing with situations where only limited projection data are available, making it appealing for various applications in image guided radiation therapy.

  7. Evaluation of registration methods on thoracic CT

    DEFF Research Database (Denmark)

    Murphy, K.; van Ginneken, B.; Reinhardt, J.

    2011-01-01

    method and the evaluation is independent, using the same criteria for all participants. All results are published on the EMPIRE10 website (http://empire10.isi.uu.nl). The challenge remains ongoing and open to new participants. Full results from 24 algorithms have been published at the time of writing......EMPIRE10 (Evaluation of Methods for Pulmonary Image REgistration 2010) is a public platform for fair and meaningful comparison of registration algorithms which are applied to a database of intra-patient thoracic CT image pairs. Evaluation of non-rigid registration techniques is a non trivial task....... This article details the organisation of the challenge, the data and evaluation methods and the outcome of the initial launch with 20 algorithms. The gain in knowledge and future work are discussed....

  8. A multicore based parallel image registration method.

    Science.gov (United States)

    Yang, Lin; Gong, Leiguang; Zhang, Hong; Nosher, John L; Foran, David J

    2009-01-01

    Image registration is a crucial step for many image-assisted clinical applications such as surgery planning and treatment evaluation. In this paper we proposed a landmark based nonlinear image registration algorithm for matching 2D image pairs. The algorithm was shown to be effective and robust under conditions of large deformations. In landmark based registration, the most important step is establishing the correspondence among the selected landmark points. This usually requires an extensive search which is often computationally expensive. We introduced a nonregular data partition algorithm using the K-means clustering algorithm to group the landmarks based on the number of available processing cores. The step optimizes the memory usage and data transfer. We have tested our method using IBM Cell Broadband Engine (Cell/B.E.) platform.

  9. CT image registration in sinogram space

    International Nuclear Information System (INIS)

    Mao Weihua; Li Tianfang; Wink, Nicole; Xing Lei

    2007-01-01

    Object displacement in a CT scan is generally reflected in CT projection data or sinogram. In this work, the direct relationship between object motion and the change of CT projection data (sinogram) is investigated and this knowledge is applied to create a novel algorithm for sinogram registration. Calculated and experimental results demonstrate that the registration technique works well for registering rigid 2D or 3D motion in parallel and fan beam samplings. Problem and solution for 3D sinogram-based registration of metallic fiducials are also addressed. Since the motion is registered before image reconstruction, the presented algorithm is particularly useful when registering images with metal or truncation artifacts. In addition, this algorithm is valuable for dealing with situations where only limited projection data are available, making it appealing for various applications in image guided radiation therapy

  10. Fractional Regularization Term for Variational Image Registration

    Directory of Open Access Journals (Sweden)

    Rafael Verdú-Monedero

    2009-01-01

    Full Text Available Image registration is a widely used task of image analysis with applications in many fields. Its classical formulation and current improvements are given in the spatial domain. In this paper a regularization term based on fractional order derivatives is formulated. This term is defined and implemented in the frequency domain by translating the energy functional into the frequency domain and obtaining the Euler-Lagrange equations which minimize it. The new regularization term leads to a simple formulation and design, being applicable to higher dimensions by using the corresponding multidimensional Fourier transform. The proposed regularization term allows for a real gradual transition from a diffusion registration to a curvature registration which is best suited to some applications and it is not possible in the spatial domain. Results with 3D actual images show the validity of this approach.

  11. Corporate Governance, Cash Holdings, and Firm Value: Evidence from Japan

    OpenAIRE

    Qi Luo; Toyohiko Hachiya

    2005-01-01

    This paper presents evidence on cash holdings for Japanese firms listed on the Tokyo Stock Exchange, focusing on the impact of corporate governance factors in cash holdings and the implication of cash holdings to firm value. We find that insider ownership and bank relations of firms play a significant role in determining cash holdings. Our results indicate that foreign stockholders select profitable firms to invest, and these firms have higher levels of cash. We document evidence that cash ho...

  12. Governance mechanisms, investment opportunity set and SMEs cash holdings

    OpenAIRE

    Belghitar, Yacine; Khan, James

    2013-01-01

    This study analyses the effect of firm characteristics and governance mechanisms on cash holdings for a sample of UK SMEs. The results show that UK SMEs with greater cash flow volatility and institutional investors hold more cash; whereas levered and dividend paying SMEs with non-executive ownership hold less cash. We also find that ownership structure is significant only in explaining the cash holdings for firms with high growth investment opportunities, and leverage is only significant in e...

  13. Serial volumetric registration of pulmonary CT studies

    Science.gov (United States)

    Silva, José Silvestre; Silva, Augusto; Sousa Santos, Beatriz

    2008-03-01

    Detailed morphological analysis of pulmonary structures and tissue, provided by modern CT scanners, is of utmost importance as in the case of oncological applications both for diagnosis, treatment, and follow-up. In this case, a patient may go through several tomographic studies throughout a period of time originating volumetric sets of image data that must be appropriately registered in order to track suspicious radiological findings. The structures or regions of interest may change their position or shape in CT exams acquired at different moments, due to postural, physiologic or pathologic changes, so, the exams should be registered before any follow-up information can be extracted. Postural mismatching throughout time is practically impossible to avoid being particularly evident when imaging is performed at the limiting spatial resolution. In this paper, we propose a method for intra-patient registration of pulmonary CT studies, to assist in the management of the oncological pathology. Our method takes advantage of prior segmentation work. In the first step, the pulmonary segmentation is performed where trachea and main bronchi are identified. Then, the registration method proceeds with a longitudinal alignment based on morphological features of the lungs, such as the position of the carina, the pulmonary areas, the centers of mass and the pulmonary trans-axial principal axis. The final step corresponds to the trans-axial registration of the corresponding pulmonary masked regions. This is accomplished by a pairwise sectional registration process driven by an iterative search of the affine transformation parameters leading to optimal similarity metrics. Results with several cases of intra-patient, intra-modality registration, up to 7 time points, show that this method provides accurate registration which is needed for quantitative tracking of lesions and the development of image fusion strategies that may effectively assist the follow-up process.

  14. Laser interrogation of latent vehicle registration number

    Energy Technology Data Exchange (ETDEWEB)

    Russo, R.E. [Lawrence Berkeley Lab., CA (United States). Energy and Environment Div.]|[Lawrence Livermore National Lab., CA (United States). Forensic Science Center; Pelkey, G.E. [City of Livermore Police Dept., CA (United States); Grant, P.; Whipple, R.E.; Andresen, B.D. [Lawrence Livermore National Lab., CA (United States). Forensic Science Center

    1994-09-01

    A recent investigation involved automobile registration numbers as important evidentiary specimens. In California, as in most states, small, thin metallic decals are issued to owners of vehicles each year as the registration is renewed. The decals are applied directly to the license plate of the vehicle and typically on top of the previous year`s expired decal. To afford some degree of security, the individual registration decals have been designed to tear easily; they cannot be separated from each other, but can be carefully removed intact from the metal license plate by using a razor blade. In September 1993, the City of Livermore Police Department obtained a blue 1993 California decal that had been placed over an orange 1992 decal. The two decals were being investigated as possible evidence in a case involving vehicle registration fraud. To confirm the suspicion and implicate a suspect, the department needed to known the registration number on the bottom (completely covered) 1992 decal. The authors attempted to use intense and directed light to interrogate the colored stickers. Optical illumination using a filtered white-light source partially identified the latent number. However, the most successful technique used a tunable dye laser pumped by a pulsed Nd:YAG laser. By selectively tuning the wavelength and intensity of the dye laser, backlit illumination of the decals permitted visualization of the underlying registration number through the surface of the top sticker. With optimally-tuned wavelength and intensity, 100% accuracy was obtained in identifying the sequence of latent characters. The advantage of optical techniques is their completely nondestructive nature, thus preserving the evidence for further interrogation or courtroom presentation.

  15. Study of Sage (Salvia officinalis L. Cultivation in Condition of Using Irrigated Water Polluted By Cadmium and Lead

    Directory of Open Access Journals (Sweden)

    Sh. Amirmoradi

    2017-01-01

    Full Text Available Introduction: Accumulation of heavy metals in agronomic soils continuously by contaminated waste waters not only causes to contamination of soils but also it affects food quality and security. Cadmium and lead are one of the most important heavy metals due to long permanence and persistence in soil can cause problems to human and animal health. Some medicinal plants are able to accumulate of heavy metals from contaminated soils. Heavy metals are not able to enter in the essential oil of some aromatic plants. Study of these plants helps human to select them for cultivating the resistant medicinal plants in contaminated soils. Materials and Methods: This experiment was carried out in the research greenhouse of agriculture faculty of Ferdowsi university of Mashhad in 2011. Seeds were cultivated in planting aprons into peat moss medium. Then the uniform plantlets were transferred into soil in the plastic boxes (30×50×35 cm at two leaf stage. In each box 6 plantlets were sown with distance of 15 cm on the planting rows and 20 cm between rows. Experiment was set up as factorial on the basis of randomized complete block design with three replications. The first factor was cadmium concentrations consisted of 0,10,20,40 mg per kilogram and the second factor was lead concentrations consisted of 0,100,300 and 600 mg/kg. Plants were irrigated during of15 weeks with cadmium and lead nitrogen nitrate solutions and then irrigated with distilled water. The differences of nitrogen amounts in treatments were compensated with ammonium nitrate on the basis of differences between level of the highest treatment and the treatment which obtained lower amount of nitrogen. Plants were harvested after 180 days at the beginning of flowering. All shoots and roots were weighted separately as fresh weight and then were dried under shading and then were weighted. The essential oil sage was determined by using of 30 grams of dried sage leaves with distillation method with

  16. Event Registration System for INR Linac

    International Nuclear Information System (INIS)

    Grekhov, O.V.; Drugakov, A.N.; Kiselev, Yu.V.

    2006-01-01

    The software of the Event registration system for the linear accelerators is described. This system allows receiving of the information on changes of operating modes of the accelerator and supervising of hundreds of key parameters of various systems of the accelerator. The Event registration system consists of the source and listeners of events. The sources of events are subroutines built in existing ACS Linac. The listeners of events are software Supervisor and Client ERS. They are used for warning the operator about change controlled parameter of the accelerator

  17. Registration of deformed multimodality medical images

    International Nuclear Information System (INIS)

    Moshfeghi, M.; Naidich, D.

    1989-01-01

    The registration and combination of images from different modalities have several potential applications, such as functional and anatomic studies, 3D radiation treatment planning, surgical planning, and retrospective studies. Image registration algorithms should correct for any local deformations caused by respiration, heart beat, imaging device distortions, and so forth. This paper reports on an elastic matching technique for registering deformed multimodality images. Correspondences between contours in the two images are used to stretch the deformed image toward its goal image. This process is repeated a number of times, with decreasing image stiffness. As the iterations continue, the stretched image better approximates its goal image

  18. Evaluating a method for automated rigid registration

    DEFF Research Database (Denmark)

    Darkner, Sune; Vester-Christensen, Martin; Larsen, Rasmus

    2007-01-01

    to point distance. T-test for common mean are used to determine the performance of the two methods (supported by a Wilcoxon signed rank test). The performance influence of sampling density, sampling quantity, and norms is analyzed using a similar method.......We evaluate a novel method for fully automated rigid registration of 2D manifolds in 3D space based on distance maps, the Gibbs sampler and Iterated Conditional Modes (ICM). The method is tested against the ICP considered as the gold standard for automated rigid registration. Furthermore...

  19. 49 CFR 178.338-9 - Holding time.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Holding time. 178.338-9 Section 178.338-9... Specifications for Containers for Motor Vehicle Transportation § 178.338-9 Holding time. (a) “Holding time” is the time, as determined by testing, that will elapse from loading until the pressure of the contents...

  20. 76 FR 35085 - Savings and Loan Holding Company Application

    Science.gov (United States)

    2011-06-15

    ... DEPARTMENT OF THE TREASURY Office of Thrift Supervision Savings and Loan Holding Company... Proposal: Savings Loan Holding Company Application. OMB Number: 1550-0015. Form Numbers: H-(e). Description... that no company, or any director or officer of a savings and loan holding company, or any individual...

  1. Creditor rights, country governance, and corporate cash holdings

    NARCIS (Netherlands)

    Seifert, Bruce; Gonenc, Halit

    2016-01-01

    This study examines the impact of creditor rights and country governance on cash holdings using a sample of firms from 47 countries. We hypothesize that cash holdings are smaller when both creditor rights and country governance are high. In these circumstances firms will not need to hold as much

  2. 12 CFR 575.14 - Subsidiary holding companies.

    Science.gov (United States)

    2010-01-01

    ... follows: Federal MHC Subsidiary Holding Company Charter Section 1. Corporate title. The full corporate... subsidiary holding company available for distribution, in cash or in kind. Each share of common stock shall... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Subsidiary holding companies. 575.14 Section...

  3. "Hold Harmless" Option for Staff Babysitting and Employee References

    Science.gov (United States)

    Bruno, Holly Elissa

    2010-01-01

    Help for educators and administrators may be on the way in the form of "hold harmless" documents that allow for flexibility in enforcing program policies. Having a "No Babysitting policy," and "Hold Harmless" documentation will not stop one's program from being sued. However, with the "No Babysitting policy" and "Hold Harmless" documentation…

  4. Using resistance and resilience concepts to reduce impacts of annual grasses and altered fire regimes on the sagebrush ecosystem and sage-grouse- A strategic multi-scale approach

    Science.gov (United States)

    Chambers, Jeanne C.; Pyke, David A.; Maestas, Jeremy D.; Boyd, Chad S.; Campbell, Steve; Espinosa, Shawn; Havlina, Doug; Mayer, Kenneth F.; Wuenschel, Amarina

    2014-01-01

    This Report provides a strategic approach for conservation of sagebrush ecosystems and Greater Sage- Grouse (sage-grouse) that focuses specifically on habitat threats caused by invasive annual grasses and altered fire regimes. It uses information on factors that influence (1) sagebrush ecosystem resilience to disturbance and resistance to invasive annual grasses and (2) distribution, relative abundance, and persistence of sage-grouse populations to develop management strategies at both landscape and site scales. A sage-grouse habitat matrix links relative resilience and resistance of sagebrush ecosystems with sage-grouse habitat requirements for landscape cover of sagebrush to help decision makers assess risks and determine appropriate management strategies at landscape scales. Focal areas for management are assessed by overlaying matrix components with sage-grouse Priority Areas for Conservation (PACs), breeding bird densities, and specific habitat threats. Decision tools are discussed for determining the suitability of focal areas for treatment and the most appropriate management treatments.

  5. 78 FR 31590 - Sears Holdings Management Corporation, A Division Of Sears Holdings Corporation, Hoffman Estates...

    Science.gov (United States)

    2013-05-24

    ... (``My position at Sears had nothing to do with Analytics or space Management. I worked in Marketing... firm clarified that one petitioner supplied print marketing management services, another petitioner... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-81,253] Sears Holdings Management...

  6. Identification of New Compounds from Sage Flowers (Salvia officinalis L.) as Markers for Quality Control and the Influence of the Manufacturing Technology on the Chemical Composition and Antibacterial Activity of Sage Flower Extracts.

    Science.gov (United States)

    Gericke, Sebastian; Lübken, Tilo; Wolf, Diana; Kaiser, Martin; Hannig, Christian; Speer, Karl

    2018-02-28

    Parts of Salvia species such as its flowers and leaves are currently used as a culinary herb and for some medicinal applications. To distinguish the different sage extracts it is necessary to analyze their individual chemical compositions. Their characteristic compounds might be established as markers to differentiate between sage flowers and leaf extracts or to determine the manufacturing technology and storage conditions. Tri-p-coumaroylspermidine can be detected only in flowers and has been described here for Salvia and Lavandula species for the first time. Markers for oxidation processes are the novel compounds salviquinone A and B, which were generated from carnosol by exposure to oxygen. Caffeic acid ethyl ester was established as an indirect marker for the usage of ethanol as extraction solvent. The compounds were identified by LC-QTOF-HRESIMS, LC-MS, NMR, IR, and single-crystal X-ray diffraction after isolation by semipreparative HPLC. Furthermore, sage flower resin showed interesting antibacterial in vitro activities against Gram-positive and Gram-negative bacteria.

  7. Assessment of rigid multi-modality image registration consistency using the multiple sub-volume registration (MSR) method

    International Nuclear Information System (INIS)

    Ceylan, C; Heide, U A van der; Bol, G H; Lagendijk, J J W; Kotte, A N T J

    2005-01-01

    Registration of different imaging modalities such as CT, MRI, functional MRI (fMRI), positron (PET) and single photon (SPECT) emission tomography is used in many clinical applications. Determining the quality of any automatic registration procedure has been a challenging part because no gold standard is available to evaluate the registration. In this note we present a method, called the 'multiple sub-volume registration' (MSR) method, for assessing the consistency of a rigid registration. This is done by registering sub-images of one data set on the other data set, performing a crude non-rigid registration. By analysing the deviations (local deformations) of the sub-volume registrations from the full registration we get a measure of the consistency of the rigid registration. Registration of 15 data sets which include CT, MR and PET images for brain, head and neck, cervix, prostate and lung was performed utilizing a rigid body registration with normalized mutual information as the similarity measure. The resulting registrations were classified as good or bad by visual inspection. The resulting registrations were also classified using our MSR method. The results of our MSR method agree with the classification obtained from visual inspection for all cases (p < 0.02 based on ANOVA of the good and bad groups). The proposed method is independent of the registration algorithm and similarity measure. It can be used for multi-modality image data sets and different anatomic sites of the patient. (note)

  8. Antibacterial activity of oregano and sage plant extracts against decarboxylase-positive enterococci isolated from rabbit meat

    Directory of Open Access Journals (Sweden)

    Ľubica Chrastinová

    2013-02-01

    Full Text Available The effect of plant extracts (sage, oregano against decarboxylase-positive enterococci from rabbit back limb meat  was reported in this study. Oregano plant extract inhibited the growth of all 34 tested enterococci (the inhibitory zones: 12 to 45 mm. The growth of the majority of strains  (n=23 was inhibited by oregano plant extract (the high size inhibitory zones (higher than 25 mm. The growth of 11 strains  was inhibited by oregano extract reaching medium size inhibitory zones (10 to 25mm. The most sensitive strain to oregano extract was E. faecium M7bA (45 mm. Sage extract was less active against tested enterococci (n=16  reaching lower inhibitory zones (up to 10 mm. doi:10.5219/239 Normal 0 21 false false false SK X-NONE X-NONE

  9. Effect of sage (Salvia officinalis) on the oxidative stability of Chinese-style sausage during refrigerated storage.

    Science.gov (United States)

    Zhang, L; Lin, Y H; Leng, X J; Huang, M; Zhou, G H

    2013-10-01

    The objective of this study was to assess the effect of sage, at levels of 0.05%, 0.1% and 0.15% (w/w), on the oxidative stability of Chinese-style sausage stored at 4°C for 21 days. The results showed that inclusion of sage in sausages resulted in lower L* values (Psage showed significantly retarded increases in TBARS values, and in the formation of protein carbonyls (Psage to the sausages at levels of 0.1% and 0.15% reduced textural deterioration during refrigerated storage (PSage used in this study had no negative effects on the sensory properties of sausages. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Comparing Simultaneous Stratospheric Aerosol and Ozone Lidar Measurements with SAGE 2 Data after the Mount Pinatubo Eruption

    Science.gov (United States)

    Yue, G. K.; Poole, L. R.; McCormick, M. P.; Veiga, R. E.; Wang, P.-H.; Rizi, V.; Masci, F.; DAltorio, A.; Visconti, G.

    1995-01-01

    Stratospheric aerosol and ozone profiles obtained simultaneously from the lidar station at the University of L'Aquila (42.35 deg N, 13.33 deg E, 683 m above sea level) during the first 6 months following the eruption of Mount Pinatubo are compared with corresponding nearby Stratospheric Aerosol and Gas Experiment (SAGE) 2 profiles. The agreement between the two data sets is found to be reasonably good. The temporal change of aerosol profiles obtained by both techniques showed the intrusion and growth of Pinatubo aerosols. In addition, ozone concentration profiles derived from an empirical time-series model based on SAGE 2 ozone data obtained before the Pinatubo eruption are compared with measured profiles. Good agreement is shown in the 1991 profiles, but ozone concentrations measured in January 1992 were reduced relative to time-series model estimates. Possible reasons for the differences between measured and model-based ozone profiles are discussed.

  11. Comparison of SAGE 2 ozone measurements and ozone soundings at Uccle (Belgium) during the period February 1985 to January 1986

    Science.gov (United States)

    Debacker, Hugo; Demuer, Dirk; Veiga, R. E.; Zawodny, J. M.

    1994-01-01

    The ozone profiles obtained from 24 balloon soundings, at 50 deg 48 min N, 4 deg 21 min E, carried out with the electro-chemical ozonesondes are discussed. The data were used as correlative data to the ozone profiles acquired by the Stratospheric Aerosol and Gas Experiment (SAGE 2). Good agreement was obtained between the two data sets. The difference of percentage between the ozone column density of the mean balloon and SAGE profile is 4.4% in the altitude region between 10 to 26 km. From the statistical analysis it seems that there is a difference between the mean profiles at the level of the ozone maximum and around the 30 km level. Similar results are obtained with an error analysis of both data. The differences between the mean profiles in the lower stratosphere are probably real, and are due to the presence of ozone.

  12. Acoustic communication in the Greater Sage-Grouse (Centrocercus urophasianus) an examination into vocal sacs, sound propagation, and signal directionality

    Science.gov (United States)

    Dantzker, Marc Steven

    The thesis is an inquiry into the acoustic communication of a very unusual avian species, the Greater Sage-Grouse, Centrocercus urophasianus. One of the most outstanding features of this animal's dynamic mating display is its use of paired air sacs that emerge explosively from an esophageal pouch. My first line of inquiry into this system is a review of the form and function of similar vocal apparatuses, collectively called vocal sacs, in birds. Next, with a combination of mathematical models and field measurements, My collaborator and I investigate the acoustic environment where the Greater Sage-Grouse display. The complexities of this acoustic environment are relevant both to the birds and to the subsequent examinations of the display's properties. Finally, my collaborators and I examine a cryptic component of the acoustic display --- directionality --- which we measured simultaneously from multiple locations around free moving grouse on their mating grounds.

  13. ATR-FTIR Spectroscopy on intact dried leaves of sage (Salvia officinalis L. – chemotaxonomic discrimination and essential oil composition

    Directory of Open Access Journals (Sweden)

    Gudi, Gennadi

    2016-07-01

    Full Text Available Sage (Salvia officinalis L. is cultivated worldwide for its aromatic leaves which are used as herbal spice and for phytopharmaceutical applications. Fast analytical strategies for essential oil analysis, performed directly on plant material would reduce the delay between sampling and analytical results. This would enhance product quality by improving technical control of cultivation. The attenuated total reflectance Fourier transform infrared (ATR-FTIR spectroscopy method described here provides a reliable calibration model for quantification of essential oil components (EOC and its main constituents (e.g. -thujone and -thujone directly on dried, intact leaves of sage. Except for drying no further sample preparation is required for ATR-FTIR and the measurement time of less than 5 min per sample contrasts with the most common alternative of hydro-distillation followed by GC analysis which can take several hours per sample.

  14. Improved SAGE II cloud/aerosol categorization and observations of the Asian tropopause aerosol layer: 1989–2005

    Directory of Open Access Journals (Sweden)

    L. W. Thomason

    2013-05-01

    Full Text Available We describe the challenges associated with the interpretation of extinction coefficient measurements by the Stratospheric Aerosol and Gas Experiment (SAGE II in the presence of clouds. In particular, we have found that tropospheric aerosol analyses are highly dependent on a robust method for identifying when clouds affect the measured extinction coefficient. Herein, we describe an improved cloud identification method that appears to capture cloud/aerosol events more effectively than early methods. In addition, we summarize additional challenges to observing the Asian Tropopause Aerosol Layer (ATAL using SAGE II observations. Using this new approach, we perform analyses of the upper troposphere, focusing on periods in which the UTLS (upper troposphere/lower stratosphere is relatively free of volcanic material (1989–1990 and after 1996. Of particular interest is the Asian monsoon anticyclone where CALIPSO (Cloud-Aerosol Lidar Pathfinder Satellite Observations has observed an aerosol enhancement. This enhancement, called the ATAL, has a similar morphology to observed enhancements in long-lived trace gas species like CO. Since the CALIPSO record begins in 2006, the question of how long this aerosol feature has been present requires a new look at the long-lived SAGE II data sets despite significant hurdles to its use in the subtropical upper troposphere. We find that there is no evidence of ATAL in the SAGE II data prior to 1998. After 1998, it is clear that aerosol in the upper troposphere in the ATAL region is substantially enhanced relative to the period before that time. In addition, the data generally supports the presence of the ATAL beginning in 1999 and continuing through the end of the mission, though some years (e.g., 2003 are complicated by the presence of episodic enhancements most likely of volcanic origin.

  15. The effects of adding agrimony and sage extracts to water on blood biochemistry and meat quality of broiler chickens

    OpenAIRE

    Peter Supuka; Slavomír Marcinčák; Peter Popelka; Vladimír Petrovič; Ladislav Molnár; Iveta Maskaľová; Pavol Kovalík; Dana Marcinčáková; Anna Supuková; Peter Turek

    2015-01-01

    The aim of our study was to determine the effects of supplementation of agrimony extract (Agrimonia eupatoria L.) and a combination of agrimony with sage extract (Salvia officinalis L.) to water during the fattening period of broiler chickens on selected biochemical and antioxidant indicators in blood, and on the nutritional composition and oxidative stability of meat. A total of 117 Cobb 500 chicks were randomly divided on the day of hatching into three groups (n = 39 in each) and fattened f...

  16. SAGE-SMC: Surveying the Agents of Galaxy Evolution in the Tidally-Disrupted, Low-Metallicity Small Magellanic Cloud

    Science.gov (United States)

    Gordon, Karl; Babler, Brian; Bernard, Jean-Philippe; Block, Miwa; Blum, Robert; Bolatto, Alberto; Bot, Caroline; Bracker, Steve; Carlson, Lynn; Churchwell, Ed; Clayton, Geoffrey; Cohen, Martin; Engelbracht, Charles; Fukui, Yasuo; Gorjian, Varoujan; Harris, Jason; Hony, Sacha; Hora, Joseph; Indebetouw, Remy; Israel, Frank; Kawamura, Akiko; Leroy, Adam; Li, Aigen; Madden, Suzanne; Markwick-Kemper, Ciska; Meade, Marilyn; Meixner, Margaret; Misselt, Karl; Mizuno, Norikazu; Mizuno, Akira; Muller, Erik; Oliveira, Joana; Olsen, Knut; Onishi, Toshikazu; Paladini, Roberta; Points, Sean; Reach, William; Robitaille, Thomas; Rubin, Douglas; Sandstrom, Karin; Sato, Shuji; Sewilo, Marta; Shibai, Hiroshi; Simon, Josh; Smith, Linda; Srinivasan, Sundar; Tielens, Xander; van Dyk, Schuyler; van Loon, Jacco; Vijh, Uma; Volk, Kevin; Whitney, Barbara; Zaritsky, Dennis

    2007-05-01

    The observable properties of galaxy evolution are largely driven by the life-cycle of baryonic matter: stars precipitate out of a complex, multi-phase interstellar medium; and eventually, evolved stellar populations return enriched material back to the ISM via stellar winds or supernova explosions. As demonstrated by the SAGE-LMC survey, comprehensive Spitzer imaging of a nearby galaxy provides an incredibly rich view of this baryonic lifecycle, allowing for an unprecedented understanding of the physical processes which drive galaxy evolution. This proposal will extend the SAGE analysis to the whole SMC (Bar, Wing, and high-density portion of the Magellanic Bridge), a galaxy whose properties are uniquely similar to those of star-forming galaxies at high redshift. Specifically, the SMC's metallicity is below the critical threshold (1/3-1/4 Z_sun) where interstellar medium properties are observed to change dramatically (sharp reduction in the PAH dust mass fraction, reduced dust-to-gas ratio, and extreme ultraviolet extinction curve variations). In addition, the SMC has been profoundly influenced by past interactions with the LMC and Milky Way, allowing us to study the impact of periodic interactions on the structure of the ISM and the physical processes of star formation. We will gain crucial insight into the ISM and star formation in a known tidal debris structure (Bridge portion of SMC), which has a metallicity 4 times lower than the rest of the SMC. When combined with observations of the Milky Way (GLIMPSE, MIPSGAL) and the LMC (SAGE-LMC), our survey of the SMC (SAGE-SMC) will provide a complete and detailed picture of the life-cycle of baryons in galactic environments spanning orders of magnitude in metallicity, and wide ranges in star formation history. This understanding will equip us to properly interpret the infrared properties of more distant galaxies, both in the local (e.g., SINGS) and high-redshift (e.g., GOODS and SWIRE) universe.

  17. Multiple job holding, local labor markets, and the business cycle

    Directory of Open Access Journals (Sweden)

    Barry T. Hirsch

    2016-04-01

    Full Text Available Abstract About 5 % of US workers hold multiple jobs, which can exacerbate or mitigate employment changes over the business cycle. Theory is ambiguous and prior literature is not fully conclusive. We examine the relationship between multiple job holding and local unemployment rates using a large Current Population Survey data set of workers in urban labor markets during 1998–2013. Labor markets with high unemployment have moderately lower rates of multiple job holding. Yet no relationship between multiple job holding and unemployment is found within markets over time, with near-zero estimates being precisely estimated. Multiple job holding is largely acyclic. JEL Classification: J21

  18. Long-term effects of wildfire on greater sage-grouse - integrating population and ecosystem concepts for management in the Great Basin

    Science.gov (United States)

    Coates, Peter S.; Ricca, Mark A.; Prochazka, Brian G.; Doherty, Kevin E.; Brooks, Matthew L.; Casazza, Michael L.

    2015-09-10

    Greater sage-grouse (Centrocercus urophasianus; hereinafter, sage-grouse) are a sagebrush obligate species that has declined concomitantly with the loss and fragmentation of sagebrush ecosystems across most of its geographical range. The species currently is listed as a candidate for federal protection under the Endangered Species Act (ESA). Increasing wildfire frequency and changing climate frequently are identified as two environmental drivers that contribute to the decline of sage-grouse populations, yet few studies have rigorously quantified their effects on sage-grouse populations across broad spatial scales and long time periods. To help inform a threat assessment within the Great Basin for listing sage-grouse in 2015 under the ESA, we conducted an extensive analysis of wildfire and climatic effects on sage-grouse population growth derived from 30 years of lek-count data collected across the hydrographic Great Basin of Western North America. Annual (1984–2013) patterns of wildfire were derived from an extensive dataset of remotely sensed 30-meter imagery and precipitation derived from locally downscaled spatially explicit data. In the sagebrush ecosystem, underlying soil conditions also contribute strongly to variation in resilience to disturbance and resistance to plant community changes (R&R). Thus, we developed predictions from models of post-wildfire recovery and chronic effects of wildfire based on three spatially explicit R&R classes derived from soil moisture and temperature regimes. We found evidence of an interaction between the effects of wildfire (chronically affected burned area within 5 kilometers of a lek) and climatic conditions (spring through fall precipitation) after accounting for a consistent density-dependent effect. Specifically, burned areas near leks nullifies population growth that normally follows years with relatively high precipitation. In models, this effect results in long-term population declines for sage-grouse despite cyclic

  19. Fire patterns in the range of the greater sage-grouse, 1984-2013 — Implications for conservation and management

    Science.gov (United States)

    Brooks, Matthew L.; Matchett, John R.; Shinneman, Douglas J.; Coates, Peter S.

    2015-09-10

    Fire ranks among the top three threats to the greater sage-grouse (Centrocercus urophasianus) throughout its range, and among the top two threats in the western part of its range. The national research strategy for this species and the recent U.S. Department of the Interior Secretarial Order 3336 call for science-based threats assessment of fire to inform conservation planning and fire management efforts. The cornerstone of such assessments is a clear understanding of where fires are occurring and what aspects of fire regimes may be shifting outside of their historical range of variation. This report fulfills this need by describing patterns of fire area, fire size, fire rotation, and fire season length and timing from 1984 to 2013 across the range of the greater sage-grouse. This information need is further addressed by evaluating the ecological and management implications of these fire patterns. Analyses are stratified by major vegetation types and the seven greater sage-grouse management zones, delineated regionally as four western and three eastern management zones. Soil temperature and moisture indicators of resilience to fire and resistance to cheatgrass invasion, and the potential for establishment of a grass/fire cycle, are used as unifying concepts in developing fire threat assessments for each analysis strata.

  20. Sage tea-thyme-peppermint hydrosol oral rinse reduces chemotherapy-induced oral mucositis: A randomized controlled pilot study.

    Science.gov (United States)

    Mutluay Yayla, Ezgi; Izgu, Nur; Ozdemir, Leyla; Aslan Erdem, Sinem; Kartal, Murat

    2016-08-01

    This pilot study aimed to investigate the preventive effect of sage tea-thyme-peppermint hydrosol oral rinse used in conjunction with basic oral care on chemotherapy-induced oral mucositis. An open-label randomized controlled study. Two oncology hospitals in Ankara, Turkey. Patients receiving 5-fluorouracil-based chemotherapy regimens were divided into the intervention group (N=30) and control group (N=30). Basic oral care was prescribed to the control group, while the intervention group was prescribed sage tea-thyme-peppermint hydrosol in addition to basic oral care. All patients were called to assess their compliance with the study instructions on day 5 and 14. Oral mucositis was evaluated using an inspection method or by assessing oral cavity photos based on the World Health Organization oral toxicity scale on day 5 and 14. Most of the patients in the intervention group did not develop oral mucositis on day 5. In addition, the incidence of grade 1 oral mucositis was statistically lower in the intervention group (10%) than the control group (53.3%) on day 5. By day 14, the majority of patients in both the groups had grade 0 oral mucositis. Sage tea-thyme-peppermint hydrosol oral rinse has promising results in alleviating oral mucositis. This hydrosol can be recommended for clinical use as it is well tolerated and cost-effective. However, further randomized controlled trials are needed to support the study. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Low energy solar neutrino experiments: The Soviet American Gallium Experiment (SAGE). Final report, August 12, 1988--October 31, 1994

    International Nuclear Information System (INIS)

    1995-01-01

    Two 71 Ga experiments are currently in operation. The first is the 60 ton Soviet American Gallium Experiment (SAGE) at Baksan, which has recently reported a signal level of 73+18/-16(stat)+5/-7(syst) SNU; the second is the 30 ton GALLEX experiment at Gran Sasso, which sees 87±14±7 SNU. Both results are consistent, and both suggest a neutrino flux level low compared to the total expected from standard solar model calculations. It is not possible, however, to make a case for flux levels lower than the p-p prediction. Assuming the experiments are correct (Neutrino source calibrations are planned for both SAGE and GALLEX in the near future.), it is not at all clear yet whether the answer lies with the neutrino physics, solar physics, or a combination of both. Nevertheless, though solar model effects cannot be ruled out, if the Homestake and Kamiokande results are taken at face value, then these two experiments alone imply that neutrino oscillations or some similar particle physics result must be present to some degree. This report reviews the SAGE experiment and recent results. Non-radiochemical experiments are also discussed, with an emphasis on the Kamiokande water Cerenkov results

  2. The effects of adding agrimony and sage extracts to water on blood biochemistry and meat quality of broiler chickens

    Directory of Open Access Journals (Sweden)

    Peter Supuka

    2015-01-01

    Full Text Available The aim of our study was to determine the effects of supplementation of agrimony extract (Agrimonia eupatoria L. and a combination of agrimony with sage extract (Salvia officinalis L. to water during the fattening period of broiler chickens on selected biochemical and antioxidant indicators in blood, and on the nutritional composition and oxidative stability of meat. A total of 117 Cobb 500 chicks were randomly divided on the day of hatching into three groups (n = 39 in each and fattened for 42 days. All groups were fed the same diets. In experimental group A water was supplemented with agrimony extract (0.2%. In experimental group AS water was supplemented with a combination of agrimony (0.1% and sage (0.1% extracts. Group C was control without supplementation. The total cholesterol, low density lipoproteins and malondialdehyde in serum were decreased (P P P < 0.05 in both experimental groups compared to control. Our results indicate that supplementation of agrimony and sage extract to water can beneficially influence the antioxidant status as well as oxidative stability of thigh meat and thus improve meat quality. This is a first similar study comparing addition of plant extracts to water in broiler nutrition.

  3. Low energy solar neutrino experiments: The Soviet American Gallium Experiment (SAGE). Final report, August 12, 1988--October 31, 1994

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-04-01

    Two {sup 71}Ga experiments are currently in operation. The first is the 60 ton Soviet American Gallium Experiment (SAGE) at Baksan, which has recently reported a signal level of 73+18/{minus}16(stat)+5/{minus}7(syst) SNU; the second is the 30 ton GALLEX experiment at Gran Sasso, which sees 87{+-}14{+-}7 SNU. Both results are consistent, and both suggest a neutrino flux level low compared to the total expected from standard solar model calculations. It is not possible, however, to make a case for flux levels lower than the p-p prediction. Assuming the experiments are correct (Neutrino source calibrations are planned for both SAGE and GALLEX in the near future.), it is not at all clear yet whether the answer lies with the neutrino physics, solar physics, or a combination of both. Nevertheless, though solar model effects cannot be ruled out, if the Homestake and Kamiokande results are taken at face value, then these two experiments alone imply that neutrino oscillations or some similar particle physics result must be present to some degree. This report reviews the SAGE experiment and recent results. Non-radiochemical experiments are also discussed, with an emphasis on the Kamiokande water Cerenkov results.

  4. Antimicrobial effectiveness of oregano and sage essential oils incorporated into whey protein films or cellulose-based filter paper.

    Science.gov (United States)

    Royo, Maite; Fernández-Pan, Idoya; Maté, Juan I

    2010-07-01

    In this study the antimicrobial effectiveness of oregano and sage essential oils (EOs) incorporated into two different matrices, whey protein isolate (WPI) and cellulose-based filter paper, was analysed. Antimicrobial properties of WPI-based films containing oregano and sage EOs were tested against Listeria innocua, Staphylococcus aureus and Salmonella enteritidis. Oregano EO showed antimicrobial activity against all three micro-organisms. The highest inhibition zones were against L. innocua. However, sage EO did not show antimicrobial activity against any of the micro-organisms. Antimicrobial activity was confirmed for both EOs using cellulose-based filter paper as supporting matrix, although it was significantly more intense for oregano EO. Inhibition surfaces were significantly greater when compared with those of the WPI films. This finding is likely due to the higher porosity and diffusivity of the active compounds in the filter paper. The interactions between the EOs and the films have a critical effect on the diffusivity of the active compounds and therefore on the final antimicrobial activity. As a result, to obtain active edible films, it is necessary to find the equilibrium point between the nature and concentration of the active compounds in the EO and the formulation of the film.

  5. An integrated modeling approach to estimating Gunnison Sage-Grouse population dynamics: combining index and demographic data.

    Science.gov (United States)

    Davis, Amy J.; Hooten, Mevin B.; Phillips, Michael L.; Doherty, Paul F.

    2014-01-01

    Evaluation of population dynamics for rare and declining species is often limited to data that are sparse and/or of poor quality. Frequently, the best data available for rare bird species are based on large-scale, population count data. These data are commonly based on sampling methods that lack consistent sampling effort, do not account for detectability, and are complicated by observer bias. For some species, short-term studies of demographic rates have been conducted as well, but the data from such studies are typically analyzed separately. To utilize the strengths and minimize the weaknesses of these two data types, we developed a novel Bayesian integrated model that links population count data and population demographic data through population growth rate (λ) for Gunnison sage-grouse (Centrocercus minimus). The long-term population index data available for Gunnison sage-grouse are annual (years 1953–2012) male lek counts. An intensive demographic study was also conducted from years 2005 to 2010. We were able to reduce the variability in expected population growth rates across time, while correcting for potential small sample size bias in the demographic data. We found the population of Gunnison sage-grouse to be variable and slightly declining over the past 16 years.

  6. Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions.

    Science.gov (United States)

    Russo, Alessandra; Formisano, Carmen; Rigano, Daniela; Senatore, Felice; Delfine, Sebastiano; Cardile, Venera; Rosselli, Sergio; Bruno, Maurizio

    2013-05-01

    Salvia officinalis L. can be found worldwide and its leaves are commonly used as ingredient in food industry. Sage essential oil is applied in the treatment of a range of diseases and has been shown to possess different biological activities. The objectives of our research were to study the effects of environment on crop, chemical composition and anticancer activity on S. officinalis essential oil. Sage was cultivated at eighteen experimental sites in south-central Italy (Molise) in different growing environments. The essential oils (S1-S18), extracted by hydrodistillation, were analyzed by GC and CG/MS. Results show that the main components were α-thujone, camphor, borneol, γ-muurolene and sclareol for all the samples, but the percentages of these compounds varied depending on environmental factors such as altitude, water availability and pedo-climatic conditions. The growth-inhibitory and proapoptotic effects of the eighteen sage essential oils were evaluated in three human melanoma cell lines, A375, M14, and A2058. Copyright © 2012 Elsevier Ltd. All rights reserved.

  7. 77 FR 38285 - Pesticide Products; Registration Applications

    Science.gov (United States)

    2012-06-27

    ... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2012-0101; FRL-9348-5] Pesticide Products... announces receipt of applications to register pesticide products containing new active ingredients not... Pollution Prevention Division (7511P) or the Registration Division (7505P), Office of Pesticide Programs...

  8. Business Registration Reform Case Studies : Malaysia

    OpenAIRE

    Olaisen, John

    2009-01-01

    This collection of case studies describes experiences and draws lessons from varied business registration reform programs in economies in vastly different stages of development: Bulgaria, Estonia, Ireland, Madagascar, and Malaysia. Over the last twenty years, a number of countries have recognized the importance of smooth and efficient business start up procedures. A functioning business re...

  9. 77 FR 73558 - Sex Offender Registration Amendments

    Science.gov (United States)

    2012-12-11

    .... FOR FURTHER INFORMATION CONTACT: Rorey Smith, Deputy General Counsel, (202) 220-5797, or rorey.smith... Registration and Notification Act (SORNA), Title I of the Adam Walsh Child Protection and Safety Act of 2006... (SORNA), Title I of the Adam Walsh Child Protection and Safety Act of 2006, (Pub. L. 109-248), requires a...

  10. 75 FR 13282 - Pesticide Products; Registration Applications

    Science.gov (United States)

    2010-03-19

    ..., and Quince; and Stone Fruit: Apricot, Cherry, Peach, Nectarine, and Plum. Contact: James M. Stone, (703) 305-7391, stone[email protected] . 5. Registration Numbers: 264-718, 264-719, 264-850. Docket Number... vegetables (except cucurbits) eggplant, ground cherry (physalis spp.), pepino, pepper (includes bell pepper...

  11. 2017 Joint Universities Accelerator School (JUAS) - Registrations

    CERN Multimedia

    2016-01-01

    The registrations for the 2017 session of the Joint Universities Accelerator School (JUAS) are now open.   Applications are welcome from staff, fellows and post-graduate students wishing to further their knowledge in the field. The deadline for submission of the full application form is 16 October 2016.

  12. Registrering af biometriske og biologiske personoplysninger

    DEFF Research Database (Denmark)

    Blume, Peter Erik; Herrmann, Janne Rothmar

    2009-01-01

    Med udgangspunkt i menneskeretsdomstolens Marper dom drøftes i artiklen indretningen af dansk rets regler om registrering af fingeraftryk og dna-profil med tilhørende biologisk materiale, og om dommen nødvendiggør ændringer af disse regler....

  13. Regulations for the Registration of Agreements

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1959-11-06

    The Regulations for the Registration of Agreements adopted by the Board of Governors on 25 April 1958 in implementation of Article XXII.B of the Statute of the Agency are reproduced in this document for the information of all Members.

  14. 9 CFR 2.30 - Registration.

    Science.gov (United States)

    2010-01-01

    ... being in an inactive status. (3) A research facility which goes out of business or which ceases to function as a research facility, or which changes its method of operation so that it no longer uses... WELFARE REGULATIONS Research Facilities § 2.30 Registration. (a) Requirements and procedures. (1) Each...

  15. 76 FR 42684 - Statutory Invention Registration

    Science.gov (United States)

    2011-07-19

    ... 3.00 Totals 8 10.00 There is annual (non-hour) cost burden in the way of filing fees associated with...) Filing fee $ cost burden (a) (b) (a x b) (c) Statutory Invention Registration (Requested prior to 2 $920...) respondent cost burden for this collection in the form of postage costs and filing fees will be $8,170. IV...

  16. Mid-space-independent deformable image registration.

    Science.gov (United States)

    Aganj, Iman; Iglesias, Juan Eugenio; Reuter, Martin; Sabuncu, Mert Rory; Fischl, Bruce

    2017-05-15

    Aligning images in a mid-space is a common approach to ensuring that deformable image registration is symmetric - that it does not depend on the arbitrary ordering of the input images. The results are, however, generally dependent on the mathematical definition of the mid-space. In particular, the set of possible solutions is typically restricted by the constraints that are enforced on the transformations to prevent the mid-space from drifting too far from the native image spaces. The use of an implicit atlas has been proposed as an approach to mid-space image registration. In this work, we show that when the atlas is aligned to each image in the native image space, the data term of implicit-atlas-based deformable registration is inherently independent of the mid-space. In addition, we show that the regularization term can be reformulated independently of the mid-space as well. We derive a new symmetric cost function that only depends on the transformation morphing the images to each other, rather than to the atlas. This eliminates the need for anti-drift constraints, thereby expanding the space of allowable deformations. We provide an implementation scheme for the proposed framework, and validate it through diffeomorphic registration experiments on brain magnetic resonance images. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. DEVELOPMENT AND REGISTRATION OF CHIRAL DRUGS

    NARCIS (Netherlands)

    WITTE, DT; ENSING, K; FRANKE, JP; DEZEEUW, RA

    1993-01-01

    In this review we describe the impact of chirality on drug development and registration in the United States, Japan and the European Community. Enantiomers may have differences in their pharmacological profiles, and, therefore, chiral drugs ask for special analytical and pharmacological attention

  18. 2016 Joint Universities Accelerator School (JUAS) - Registrations

    CERN Multimedia

    2015-01-01

    The registrations for the 2016 session of the Joint Universities Accelerator School (JUAS) are now open.   Applications are welcome from second-year Master and PhD and for physicists wishing to further their knowledge in this particular field. The deadline for submission of the full application form is 30 October 2015.

  19. Automated Registration Of Images From Multiple Sensors

    Science.gov (United States)

    Rignot, Eric J. M.; Kwok, Ronald; Curlander, John C.; Pang, Shirley S. N.

    1994-01-01

    Images of terrain scanned in common by multiple Earth-orbiting remote sensors registered automatically with each other and, where possible, on geographic coordinate grid. Simulated image of terrain viewed by sensor computed from ancillary data, viewing geometry, and mathematical model of physics of imaging. In proposed registration algorithm, simulated and actual sensor images matched by area-correlation technique.

  20. 7 CFR 915.120 - Handler registration.

    Science.gov (United States)

    2010-01-01

    ... production area where the avocados will be prepared for market, and name and address of person responsible... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA Rules and Regulations § 915.120 Handler registration. (a) Each handler who desires to handle avocados...