WorldWideScience

Sample records for registration evaluation authorization

  1. Biometric Authorization and Registration Systems and Methods

    National Research Council Canada - National Science Library

    Caulfield, H

    2002-01-01

    Biometric authorization and registration systems and methods are disclosed. In one embodiment, the system preferably comprises a firearm that includes a biometric authorization system, a plurality of training computers, and a server...

  2. EAS Equipment Authorization Grantee Registrations

    Data.gov (United States)

    Federal Communications Commission — EAS (Equipment Authorization System). Radio Frequency (RF) devices are required to be properly authorized under 47 CFR Part 2 prior to being marketed or imported...

  3. Performance evaluation of 2D image registration algorithms with the numeric image registration and comparison platform

    International Nuclear Information System (INIS)

    Gerganov, G.; Kuvandjiev, V.; Dimitrova, I.; Mitev, K.; Kawrakow, I.

    2012-01-01

    The objective of this work is to present the capabilities of the NUMERICS web platform for evaluation of the performance of image registration algorithms. The NUMERICS platform is a web accessible tool which provides access to dedicated numerical algorithms for registration and comparison of medical images (http://numerics.phys.uni-sofia.bg). The platform allows comparison of noisy medical images by means of different types of image comparison algorithms, which are based on statistical tests for outliers. The platform also allows 2D image registration with different techniques like Elastic Thin-Plate Spline registration, registration based on rigid transformations, affine transformations, as well as non-rigid image registration based on Mobius transformations. In this work we demonstrate how the platform can be used as a tool for evaluation of the quality of the image registration process. We demonstrate performance evaluation of a deformable image registration technique based on Mobius transformations. The transformations are applied with appropriate cost functions like: Mutual information, Correlation coefficient, Sum of Squared Differences. The accent is on the results provided by the platform to the user and their interpretation in the context of the performance evaluation of 2D image registration. The NUMERICS image registration and image comparison platform provides detailed statistical information about submitted image registration jobs and can be used to perform quantitative evaluation of the performance of different image registration techniques. (authors)

  4. European regulation model for herbal medicine: The assessment of the EU monograph and the safety and efficacy evaluation in marketing authorization or registration in Member States.

    Science.gov (United States)

    Qu, Liping; Zou, Wenjun; Wang, YiTao; Wang, Mei

    2018-03-15

    The European Union (EU) has created a regulatory framework for herbal medicinal products (HMPs) since the enforcement of Directive 2004/24/EC. Substantial achievements have been made, with 1719 traditional use marketing registrations (TURs) and 859 well-established use marketing authorizations (WEU-MAs) for HMPs granted by the end of 2016. Apparently, the European regulation model has worked out well and in that the essential feature is the use of EU herbal monographs into those granted WEU-MAs and TURs. A systematic analysis of the European regulation model for HMPs and the EU herbal monograph's part of this model are undertaken to assist understanding of the EU legislation particularly for interested parties those from outside EU area, and afterwards, to help in decision-making in the HMPs registration in European market for pharmaceutical companies, as well as in the establishment of legislation in countries with strong traditional use of herbal remedies. A search of PubMed, ScienceDirect, the European Medicines Agency website and the Heads of Medicines Agencies website was conducted (up to December 2017), and the available information on regulation of HMPs in the EU was collected. The evaluation of applications by National Competent Authorities (NCAs) at a national level together with the assessment of EU monographs by the Committee on Herbal Medicinal Products (HMPC) at the European level constitute the European regulation framework for HMPs. As the scientific opinion about the safety and efficacy of HMPs from HMPC, the EU herbal monographs have been given a constitutional-based meaning to the TURs and WEU-MAs of HMPs and play a supportive function in the marketing procedure in Member States. The European framework has provided a powerful regulation model for harmonization of scientific assessment and facilitation of product marketing. For the pharmaceutical industries particularly those outside the EU, optimal use of the EU herbal monograph in their marketing

  5. Evaluation of the use of registration stickers.

    Science.gov (United States)

    2011-04-01

    This research evaluated the potential costs and benefits of doing away with license plate registration stickers as part : of the registration renewal process for Pennsylvania. The research consisted of a comprehensive literature review, a : survey of...

  6. 31 CFR 360.6 - Authorized forms of registration.

    Science.gov (United States)

    2010-07-01

    ... coowners. The form of registration “A and B” is not authorized. Examples: David R. Johnson 123-45-6789 or Anna B. Johnson. Maria S. Gonzalez 987-65-4321 or Juan C. Gonzalez. (3) Beneficiary form. A bond may be... Pension Fund of Safety Manufacturing Company, U/A with the company, dated March 31, 1996, 12-3456789...

  7. 31 CFR 315.7 - Authorized forms of registration.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Authorized forms of registration. 315.7 Section 315.7 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued...' Hospital for Crippled Children, St. Louis, MO, 12-3456789. St. Mary's Roman Catholic Church, Albany, NY, 12...

  8. 31 CFR 353.7 - Authorized forms of registration.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Authorized forms of registration. 353.7 Section 353.7 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued...' Hospital for Crippled Children, St. Louis, MO, 12-3456789. St. Mary's Roman Catholic Church, Albany, NY, 12...

  9. Audits by registrants authorized for use of radiation sources in well logging

    International Nuclear Information System (INIS)

    Jordan, O.D.

    1999-01-01

    An audit was carried out by the Argentine Nuclear Regulatory Authority to verify regulations and safe working procedures compliance by registrants authorized for use of radiation sources in well logging. A task force based on four inspection teams was organized. The audit was carried out at registrant's premises (equipment storage facilities) simultaneously. The evaluation was based on a system allowing a fast qualification of both, potential problems identified and their solutions. The results show that 95 % of the inspected locations were classified under the 'acceptable', 'good' and 'very good' headings. (author)

  10. Evaluation of registration methods on thoracic CT

    DEFF Research Database (Denmark)

    Murphy, K.; van Ginneken, B.; Reinhardt, J.

    2011-01-01

    method and the evaluation is independent, using the same criteria for all participants. All results are published on the EMPIRE10 website (http://empire10.isi.uu.nl). The challenge remains ongoing and open to new participants. Full results from 24 algorithms have been published at the time of writing......EMPIRE10 (Evaluation of Methods for Pulmonary Image REgistration 2010) is a public platform for fair and meaningful comparison of registration algorithms which are applied to a database of intra-patient thoracic CT image pairs. Evaluation of non-rigid registration techniques is a non trivial task....... This article details the organisation of the challenge, the data and evaluation methods and the outcome of the initial launch with 20 algorithms. The gain in knowledge and future work are discussed....

  11. Evaluating a method for automated rigid registration

    DEFF Research Database (Denmark)

    Darkner, Sune; Vester-Christensen, Martin; Larsen, Rasmus

    2007-01-01

    to point distance. T-test for common mean are used to determine the performance of the two methods (supported by a Wilcoxon signed rank test). The performance influence of sampling density, sampling quantity, and norms is analyzed using a similar method.......We evaluate a novel method for fully automated rigid registration of 2D manifolds in 3D space based on distance maps, the Gibbs sampler and Iterated Conditional Modes (ICM). The method is tested against the ICP considered as the gold standard for automated rigid registration. Furthermore...

  12. The Saudi Arabia Food and Drug Authority: An Evaluation of the Registration Process and Good Review Practices in Saudi Arabia in Comparison with Australia, Canada and Singapore.

    Science.gov (United States)

    Hashan, Hajed; Aljuffali, Ibrahim; Patel, Prisha; Walker, Stuart

    This study compares the current regulatory review process and good review practices at the Saudi Food and Drug Authority (SFDA) with those of regulatory agencies in Australia, Canada, and Singapore and identifies opportunities for developing the SFDA as a Regional Centre of Excellence. A questionnaire completed by the SFDA included data regarding the organisation, key milestones, review timelines, and good review practices of the agency. Similar information was obtained within the same timeframe (2014/2015) through the same standard questionnaire regarding the processes and practices for Health Canada, Singapore's Health Sciences Authority, and Australia's Therapeutic Goods Administration. All four regulatory agencies have established target times for scientific assessment and regulatory review, examine dossier sections in parallel, and separate company response time from overall timing. Additionally, all four agencies have instituted good review practices including standard operating procedures, templates, dossier monitoring, and continuous improvement processes, and assign a high priority to transparency in their relationships with the public, healthcare professionals and industry. Of the four agencies, however, only the SFDA requires a Certificate of Pharmaceutical Product (CPP) at the time of the submission and pricing negotiations before final product approval. To assist the SFDA in its efforts to become a Regional Centre of Excellence, it is suggested that the agency explore a risk stratification approach to select dossiers for verification, abridged, or full reviews; use forms of certification other than the CPP; make pricing negotiations independent to the review process; and introduce a feedback process for the quality of the dossier.

  13. Do emergency medicine journals promote trial registration and adherence to reporting guidelines? A survey of "Instructions for Authors".

    Science.gov (United States)

    Sims, Matthew T; Henning, Nolan M; Wayant, C Cole; Vassar, Matt

    2016-11-24

    The aim of this study was to evaluate the current state of two publication practices, reporting guidelines requirements and clinical trial registration requirements, by analyzing the "Instructions for Authors" of emergency medicine journals. We performed a web-based data abstraction from the "Instructions for Authors" of the 27 Emergency Medicine journals catalogued in the Expanded Science Citation Index of the 2014 Journal Citation Reports and Google Scholar Metrics h5-index to identify whether each journal required, recommended, or made no mention of the following reporting guidelines: EQUATOR Network, ICMJE, ARRIVE, CARE, CONSORT, STARD, TRIPOD, CHEERS, MOOSE, STROBE, COREQ, SRQR, SQUIRE, PRISMA-P, SPIRIT, PRISMA, and QUOROM. We also extracted whether journals required or recommended trial registration. Authors were blinded to one another's ratings until completion of the data validation. Cross-tabulations and descriptive statistics were calculated using IBM SPSS 22. Of the 27 emergency medicine journals, 11 (11/27, 40.7%) did not mention a single guideline within their "Instructions for Authors," while the remaining 16 (16/27, 59.3%) mentioned one or more guidelines. The QUOROM statement and SRQR were not mentioned by any journals whereas the ICMJE guidelines (18/27, 66.7%) and CONSORT statement (15/27, 55.6%) were mentioned most often. Of the 27 emergency medicine journals, 15 (15/27, 55.6%) did not mention trial or review registration, while the remaining 12 (12/27, 44.4%) at least mentioned one of the two. Trial registration through ClinicalTrials.gov was mentioned by seven (7/27, 25.9%) journals while the WHO registry was mentioned by four (4/27, 14.8%). Twelve (12/27, 44.4%) journals mentioned trial registration through any registry platform. The aim of this study was to evaluate the current state of two publication practices, reporting guidelines requirements and clinical trial registration requirements, by analyzing the "Instructions for Authors" of

  14. 9 CFR 201.86 - Brand inspection: Application for authorization, registration and filing of schedules, reciprocal...

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Brand inspection: Application for... STOCKYARDS ACT Inspection of Brands § 201.86 Brand inspection: Application for authorization, registration... in which branding or marking of livestock as a means of establishing ownership prevails by custom or...

  15. Development and evaluation of fixed phrase registration function for disaster response management system

    International Nuclear Information System (INIS)

    Suzuki, Takeyasu; Tsuda, Teppei

    2012-01-01

    It is important that three elements such as what happened, how it will advance, and how people should act are intelligibly transferred in disaster information from administrative organs to local residents. In this paper, authors developed the fixed phrase registration function and it was implemented in disaster response management system authors have previously developed. The system was applied to disaster response exercise in Mitsuke City, Niigata prefecture and the function was highly evaluated by employees of Mitsuke City. (author)

  16. Radiation protection and safety guide no. GRPB-G-2: notification and authorization by registration or licensing, exemption and exclusion

    International Nuclear Information System (INIS)

    Schandorf, C.; Darko, O.; Yeboah, J.; Osei, E.K.; Asiamah, S.D.

    1995-01-01

    The obligatory requirement for the notification of the Radiation Protection Board and application for authorization by registration or licensing are important elements of the national system for controlling radiation sources and practices which may be potentially harmful to people. The present document provides guidance for Notification and Authorization by Registration or Licensing. In pursuance of the provision of the Radiation Protection Instrument, 1993, L I 1559, Part II C ontrol and Use of Radiation Sources , the present Guide specifies the Radiation Protection Board (RPB) scheme of notification and authorization by registration of licensing. Criteria for exempting and excluding sources and practices from regulatory control are highlighted

  17. Comparison of Authorization/Registration/Notification Processes among Biocidal Products, Cosmetics, Plant Protection Products and Human Medicinal Products

    OpenAIRE

    Söyleriz, Yüksel

    2015-01-01

    In this study, comparison of the authorization/registration/notification processes of biocidal products, cosmetics, plant protection products and medicinal products are made and in this respect, the situation in EU is assessed.

  18. Improving alignment in Tract-based spatial statistics: evaluation and optimization of image registration.

    Science.gov (United States)

    de Groot, Marius; Vernooij, Meike W; Klein, Stefan; Ikram, M Arfan; Vos, Frans M; Smith, Stephen M; Niessen, Wiro J; Andersson, Jesper L R

    2013-08-01

    Anatomical alignment in neuroimaging studies is of such importance that considerable effort is put into improving the registration used to establish spatial correspondence. Tract-based spatial statistics (TBSS) is a popular method for comparing diffusion characteristics across subjects. TBSS establishes spatial correspondence using a combination of nonlinear registration and a "skeleton projection" that may break topological consistency of the transformed brain images. We therefore investigated feasibility of replacing the two-stage registration-projection procedure in TBSS with a single, regularized, high-dimensional registration. To optimize registration parameters and to evaluate registration performance in diffusion MRI, we designed an evaluation framework that uses native space probabilistic tractography for 23 white matter tracts, and quantifies tract similarity across subjects in standard space. We optimized parameters for two registration algorithms on two diffusion datasets of different quality. We investigated reproducibility of the evaluation framework, and of the optimized registration algorithms. Next, we compared registration performance of the regularized registration methods and TBSS. Finally, feasibility and effect of incorporating the improved registration in TBSS were evaluated in an example study. The evaluation framework was highly reproducible for both algorithms (R(2) 0.993; 0.931). The optimal registration parameters depended on the quality of the dataset in a graded and predictable manner. At optimal parameters, both algorithms outperformed the registration of TBSS, showing feasibility of adopting such approaches in TBSS. This was further confirmed in the example experiment. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. Evaluation of registration methods on thoracic CT : the EMPIRE10 challenge

    NARCIS (Netherlands)

    Murphy, K.; Ginneken, van B.; Reinhardt, J.M.; Kabus, S.; Ding, K.; Deng, Xiang; Cao, K.; Du, K.; Christensen, G.E.; Garcia, V.; Vercauteren, T.; Ayache, N.; Commowick, O.; Malandain, G.; Glocker, B.; Paragios, N.; Navab, N.; Gorbunova, V.; Sporring, J.; Bruijne, de M.; Han, Xiao; Heinrich, M.P.; Schnabel, J.A.; Jenkinson, M.; Lorenz, C.; Modat, M.; McClelland, J.R.; Ourselin, S.; Muenzing, S.E.A.; Viergever, M.A.; Nigris, De D.; Collins, D.L.; Arbel, T.; Peroni, M.; Li, R.; Sharp, G.; Schmidt-Richberg, A.; Ehrhardt, J.; Werner, R.; Smeets, D.; Loeckx, D.; Song, G.; Tustison, N.; Avants, B.; Gee, J.C.; Staring, M.; Klein, S.; Stoel, B.C.; Urschler, M.; Werlberger, M.; Vandemeulebroucke, J.; Rit, S.; Sarrut, D.; Pluim, J.P.W.

    2011-01-01

    EMPIRE10 (Evaluation of Methods for Pulmonary Image REgistration 2010) is a public platform for fair and meaningful comparison of registration algorithms which are applied to a database of intrapatient thoracic CT image pairs. Evaluation of nonrigid registration techniques is a nontrivial task. This

  20. Development and evaluation of automatic registration system for multi-range fiducials applied to augmented reality

    International Nuclear Information System (INIS)

    Ishii, Hirotake; Yang, Shoufeng; Yan, Weida; Shimoda, Hiroshi; Izumi, Masanori

    2009-01-01

    In this study, an automatic registration system was developed that can measure 3 dimensional position and orientation of multi-range fiducials automatically using a camera, laser range finder and motion bases connected to a computer. Result of the experimental evaluation shows that the measurement takes about 50 seconds per marker and RMSE (Root Mean Square Error) of the position and orientation measurement are 3.5 mm and 1.2 degrees respectively. (author)

  1. The comprehensive registration and information system of radiation protection regulatory authority in the Czech Republic

    International Nuclear Information System (INIS)

    Petrova, K.

    2004-01-01

    The central registration system in radiation protection is created in the Czech Republic since the 1997 year. Since that time the central registries of licensees, ionizing radiation sources (IRS) and occupational of workers doses has been developed by the State Office for Nuclear Safety (SUJB) in accordance with the demands of the new Czech legislation. The core of this complex information system is created by the Central Register of Licensees (CRL). The Central Register of Occupational Exposure (CROE) and the Central Register of Ionising Radiation Sources (CRIRS) are connected to CRL and provides with the list of workers their doses and relevant sources for each licensee. The Central Register of Approvals (CRA) issued by SUJB has been also created in 2002 and it was implemented into the system. The further register of inspections is recently under development. The whole system is operated in Oracle database. CRL registers all relevant information on the level of licensee, their workplaces and also on the level of smaller working units (labs, buildings, ..) where is necessary for more precise information about the placement of sources. The data are updated continuously. CROE collects personal and dosimetric data for all monitored workers in whole country. This register also includes the information on the personal radiation passports distributed by SUJB to external workers. CRIRS registers sealed IRS, devices with sealed IRS, generators and specification of workplaces with unsealed IRS. Users are obliged to report information on new source specified by Decree on radiation protection within one months. They shall report also all changes of registered data including the transfer of source to another user or to final disposal. CRA enables to issue automatically the licence in unified form and provides users with the different control tools of issued licences. Described comprehensive information system serves as very important and useful tool for effective regulation

  2. Evaluation of multi-modality CT-MRI-SPECT registration tools for radiotherapy treatment planning purposes

    International Nuclear Information System (INIS)

    Bianchini, S.; Alfonso, R.; Castillo, J.; Coca, M.; Torres, L.

    2013-01-01

    A qualitative and quantitative comparison of registration CT-CT, CT-MR and CT-SPECT performed by the different software and algorithms studies is presented. Only two studied software were full DICOM RT compatible while accepting DICOM images in any layout. Quantitative results of fiducial displacement errors were calculated for all software and available registration methods. The presented methodology demonstrated being effective for assessing the quality of studied image registration tools in the radiotherapy planning context, provided the images are free of significant geometric deformation. When implementing this methodology in real patients, the use of immobilization devices, such as thermoplastic masks, is recommended for enhanced quality of image registration. (Author)

  3. Semi-automatic construction of reference standards for evaluation of image registration

    NARCIS (Netherlands)

    Murphy, K.; Ginneken, van B.; Klein, S.; Staring, M.; Hoop, de B.J.; Viergever, M.A.; Pluim, J.P.W.

    2011-01-01

    Quantitative evaluation of image registration algorithms is a difficult and under-addressed issue due to the lack of a reference standard in most registration problems. In this work a method is presented whereby detailed reference standard data may be constructed in an efficient semi-automatic

  4. Automatic 3D MR image registration and its evaluation for precise monitoring of knee joint disease

    International Nuclear Information System (INIS)

    Cheng Yuanzhi; Jin Quan; Guo Changyong; Ding Xiaohua; Tanaka, Hisashi; Tamura, Shinichi

    2011-01-01

    We describe a technique for the registration of three dimensional (3D) knee femur surface points from MR image data sets; it is a technique that can track local cartilage thickness changes over time. In the first coarse registration step, we use the direction vectors of the volume given by the cloud of points of the MR image to correct for different knee joint positions and orientations in the MR scanner. In the second fine registration step, we propose a global search algorithm that simultaneously determines the optimal transformation parameters and point correspondences through searching a six dimensional space of Euclidean motion vectors (translation and rotation). The present algorithm is grounded on a mathematical theory- Lipschitz optimization. Compared with the other three registration approaches (iterative closest point (ICP), EM-ICP, and genetic algorithms), the proposed method achieved the highest registration accuracy on both animal and clinical data. (author)

  5. Performance evaluation of grid-enabled registration algorithms using bronze-standards

    CERN Document Server

    Glatard, T; Montagnat, J

    2006-01-01

    Evaluating registration algorithms is difficult due to the lack of gold standard in most clinical procedures. The bronze standard is a real-data based statistical method providing an alternative registration reference through a computationally intensive image database registration procedure. We propose in this paper an efficient implementation of this method through a grid-interfaced workflow enactor enabling the concurrent processing of hundreds of image registrations in a couple of hours only. The performances of two different grid infrastructures were compared. We computed the accuracy of 4 different rigid registration algorithms on longitudinal MRI images of brain tumors. Results showed an average subvoxel accuracy of 0.4 mm and 0.15 degrees in rotation.

  6. ER-1A-DEL-92 regulation. Procedure for evaluation and registration of medical equipment

    International Nuclear Information System (INIS)

    2015-01-01

    The objectives of this regulation is to provide additional guidance on the method of evaluation and registration of a medical team, so it is used by manufacturers, health institutions, testing centers and other institutions related to the topic. The provisions of this regulation apply to domestically produced medical equipment in relation to the necessary assessment for registration purposes of a medical team. However, the evaluation process may require evaluations and tests not explicitly included in this regulation, so that at each stage of the process the Center for State Control of Medical Equipment (Center) set the requirements for each computer or device class in particular.

  7. Challenges for the registration of vaccines in emerging countries: Differences in dossier requirements, application and evaluation processes.

    Science.gov (United States)

    Dellepiane, Nora; Pagliusi, Sonia

    2018-06-07

    The divergence of regulatory requirements and processes in developing and emerging countries contributes to hamper vaccines' registration, and therefore delay access to high-quality, safe and efficacious vaccines for their respective populations. This report focuses on providing insights on the heterogeneity of registration requirements in terms of numbering structure and overall content of dossiers for marketing authorisation applications for vaccines in different areas of the world. While it also illustrates the divergence of regulatory processes in general, as well as the need to avoid redundant reviews, it does not claim to provide a comprehensive view of all processes nor existing facilitating mechanisms, nor is it intended to touch upon the differences in assessments made by different regulatory authorities. This report describes the work analysed by regulatory experts from vaccine manufacturing companies during a meeting held in Geneva in May 2017, in identifying and quantifying differences in the requirements for vaccine registration in three aspects for comparison: the dossier numbering structure and contents, the application forms, and the evaluation procedures, in different countries and regions. The Module 1 of the Common Technical Document (CTD) of 10 countries were compared. Modules 2-5 of the CTDs of two regions and three countries were compared to the CTD of the US FDA. The application forms of eight countries were compared and the registration procedures of 134 importing countries were compared as well. The analysis indicates a high degree of divergence in numbering structure and content requirements. Possible interventions that would lead to significant improvements in registration efficiency include alignment in CTD numbering structure, a standardised model-application form, and better convergence of evaluation procedures. Copyright © 2018.

  8. Growth curve registration for evaluating salinity tolerance in barley

    KAUST Repository

    Meng, Rui

    2017-03-23

    Background: Smarthouses capable of non-destructive, high-throughput plant phenotyping collect large amounts of data that can be used to understand plant growth and productivity in extreme environments. The challenge is to apply the statistical tool that best analyzes the data to study plant traits, such as salinity tolerance, or plant-growth-related traits. Results: We derive family-wise salinity sensitivity (FSS) growth curves and use registration techniques to summarize growth patterns of HEB-25 barley families and the commercial variety, Navigator. We account for the spatial variation in smarthouse microclimates and in temporal variation across phenotyping runs using a functional ANOVA model to derive corrected FSS curves. From FSS, we derive corrected values for family-wise salinity tolerance, which are strongly negatively correlated with Na but not significantly with K, indicating that Na content is an important factor affecting salinity tolerance in these families, at least for plants of this age and grown in these conditions. Conclusions: Our family-wise methodology is suitable for analyzing the growth curves of a large number of plants from multiple families. The corrected curves accurately account for the spatial and temporal variations among plants that are inherent to high-throughput experiments.

  9. Growth curve registration for evaluating salinity tolerance in barley

    KAUST Repository

    Meng, Rui; Saade, Stephanie; Kurtek, Sebastian; Berger, Bettina; Brien, Chris; Pillen, Klaus; Tester, Mark A.; Sun, Ying

    2017-01-01

    Background: Smarthouses capable of non-destructive, high-throughput plant phenotyping collect large amounts of data that can be used to understand plant growth and productivity in extreme environments. The challenge is to apply the statistical tool that best analyzes the data to study plant traits, such as salinity tolerance, or plant-growth-related traits. Results: We derive family-wise salinity sensitivity (FSS) growth curves and use registration techniques to summarize growth patterns of HEB-25 barley families and the commercial variety, Navigator. We account for the spatial variation in smarthouse microclimates and in temporal variation across phenotyping runs using a functional ANOVA model to derive corrected FSS curves. From FSS, we derive corrected values for family-wise salinity tolerance, which are strongly negatively correlated with Na but not significantly with K, indicating that Na content is an important factor affecting salinity tolerance in these families, at least for plants of this age and grown in these conditions. Conclusions: Our family-wise methodology is suitable for analyzing the growth curves of a large number of plants from multiple families. The corrected curves accurately account for the spatial and temporal variations among plants that are inherent to high-throughput experiments.

  10. Evaluation of accuracy of B-spline transformation-based deformable image registration with different parameter settings for thoracic images.

    Science.gov (United States)

    Kanai, Takayuki; Kadoya, Noriyuki; Ito, Kengo; Onozato, Yusuke; Cho, Sang Yong; Kishi, Kazuma; Dobashi, Suguru; Umezawa, Rei; Matsushita, Haruo; Takeda, Ken; Jingu, Keiichi

    2014-11-01

    Deformable image registration (DIR) is fundamental technique for adaptive radiotherapy and image-guided radiotherapy. However, further improvement of DIR is still needed. We evaluated the accuracy of B-spline transformation-based DIR implemented in elastix. This registration package is largely based on the Insight Segmentation and Registration Toolkit (ITK), and several new functions were implemented to achieve high DIR accuracy. The purpose of this study was to clarify whether new functions implemented in elastix are useful for improving DIR accuracy. Thoracic 4D computed tomography images of ten patients with esophageal or lung cancer were studied. Datasets for these patients were provided by DIR-lab (dir-lab.com) and included a coordinate list of anatomical landmarks that had been manually identified. DIR between peak-inhale and peak-exhale images was performed with four types of parameter settings. The first one represents original ITK (Parameter 1). The second employs the new function of elastix (Parameter 2), and the third was created to verify whether new functions improve DIR accuracy while keeping computational time (Parameter 3). The last one partially employs a new function (Parameter 4). Registration errors for these parameter settings were calculated using the manually determined landmark pairs. 3D registration errors with standard deviation over all cases were 1.78 (1.57), 1.28 (1.10), 1.44 (1.09) and 1.36 (1.35) mm for Parameter 1, 2, 3 and 4, respectively, indicating that the new functions are useful for improving DIR accuracy, even while maintaining the computational time, and this B-spline-based DIR could be used clinically to achieve high-accuracy adaptive radiotherapy. © The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

  11. Evaluation of accuracy of B-spline transformation-based deformable image registration with different parameter settings for thoracic images

    International Nuclear Information System (INIS)

    Kanai, Takayuki; Kadoya, Noriyuki; Ito, Kengo

    2014-01-01

    Deformable image registration (DIR) is fundamental technique for adaptive radiotherapy and image-guided radiotherapy. However, further improvement of DIR is still needed. We evaluated the accuracy of B-spline transformation-based DIR implemented in elastix. This registration package is largely based on the Insight Segmentation and Registration Toolkit (ITK), and several new functions were implemented to achieve high DIR accuracy. The purpose of this study was to clarify whether new functions implemented in elastix are useful for improving DIR accuracy. Thoracic 4D computed tomography images of ten patients with esophageal or lung cancer were studied. Datasets for these patients were provided by DIR-lab (dir-lab.com) and included a coordinate list of anatomical landmarks that had been manually identified. DIR between peak-inhale and peak-exhale images was performed with four types of parameter settings. The first one represents original ITK (Parameter 1). The second employs the new function of elastix (Parameter 2), and the third was created to verify whether new functions improve DIR accuracy while keeping computational time (Parameter 3). The last one partially employs a new function (Parameter 4). Registration errors for these parameter settings were calculated using the manually determined landmark pairs. 3D registration errors with standard deviation over all cases were 1.78 (1.57), 1.28 (1.10), 1.44 (1.09) and 1.36 (1.35) mm for Parameter 1, 2, 3 and 4, respectively, indicating that the new functions are useful for improving DIR accuracy, even while maintaining the computational time, and this B-spline-based DIR could be used clinically to achieve high-accuracy adaptive radiotherapy. (author)

  12. Registration quality evaluator: application to automated patient setup verification in radiotherapy

    Science.gov (United States)

    Wu, Jian; Samant, Sanjiv S.

    2004-05-01

    An image registration quality evaluator (RQE) is proposed to automatically quantify the accuracy of registrations. The RQE, based on an adaptive pattern classifier, is generated from a pair of reference and target images. It is unique to each patient, anatomical site and imaging modality. RQE is applied to patient positioning in cranial radiotherapy using portal/portal and portal/DRR registrations. We adopted 1mm translation and 1° rotation as the maximal acceptable registration errors, reflecting typical clinical setup tolerances. RQE is used to determine the acceptability of a registration. The performance of RQE was evaluated using phantom images containing radio-opaque fiducial markers. Using receiver operating characteristic (ROC) analysis, we estimated the sensitivity and the specificity of the RQE are 0.95 (with 0.89-0.98 confidence interval (CI) at 95% significance level) and 0.95 (with 0.88-0.98 CI at 95% significance level) respectively for intramodal RQE. For intermodal RQE, the sensitivity and the specificity are 0.92 (with 0.81-0.98 CI at 95% significance level) and 0.98 (with 0.89-0.99 CI at 95% significance level) respectively. Clinical use of RQE could significantly reduce the involvement of the oncologist for routine pre-treatment patient positioning verification, while increasing setup accuracy.

  13. FEM-based evaluation of deformable image registration for radiation therapy

    International Nuclear Information System (INIS)

    Zhong Hualiang; Peters, Terry; Siebers, Jeffrey V

    2007-01-01

    This paper presents a new concept to automatically detect the neighborhood in an image where deformable registration is mis-performing. Specifically, the displacement vector field (DVF) from a deformable image registration is substituted into a finite-element-based elastic framework to calculate unbalanced energy in each element. The value of the derived energy indicates the quality of the DVF in its neighborhood. The new voxel-based evaluation approach is compared with three other validation criteria: landmark measurement, a finite element approach and visual comparison, for deformable registrations performed with the optical-flow-based 'demons' algorithm as well as thin-plate spline interpolation. This analysis was performed on three pairs of prostate CT images. The results of the analysis show that the four criteria give mutually comparable quantitative assessments on the six registration instances. As an objective concept, the unbalanced energy presents no requirement on boundary constraints in its calculation, different from traditional mechanical modeling. This method is automatic, and at voxel level suitable to evaluate deformable registration in a clinical setting

  14. Evaluation of whole‐body MR to CT deformable image registration

    Science.gov (United States)

    Akbarzadeh, A.; Gutierrez, D.; Baskin, A.; Ay, M.R.; Ahmadian, A.; Alam, N. Riahi; Lövblad, KO

    2013-01-01

    Multimodality image registration plays a crucial role in various clinical and research applications. The aim of this study is to present an optimized MR to CT whole‐body deformable image registration algorithm and its validation using clinical studies. A 3D intermodality registration technique based on B‐spline transformation was performed using optimized parameters of the elastix package based on the Insight Toolkit (ITK) framework. Twenty‐eight (17 male and 11 female) clinical studies were used in this work. The registration was evaluated using anatomical landmarks and segmented organs. In addition to 16 anatomical landmarks, three key organs (brain, lungs, and kidneys) and the entire body volume were segmented for evaluation. Several parameters — such as the Euclidean distance between anatomical landmarks, target overlap, Dice and Jaccard coefficients, false positives and false negatives, volume similarity, distance error, and Hausdorff distance — were calculated to quantify the quality of the registration algorithm. Dice coefficients for the majority of patients (>75%) were in the 0.8–1 range for the whole body, brain, and lungs, which satisfies the criteria to achieve excellent alignment. On the other hand, for kidneys, Dice coefficients for volumes of 25% of the patients meet excellent volume agreement requirement, while the majority of patients satisfy good agreement criteria (>0.6). For all patients, the distance error was in 0–10 mm range for all segmented organs. In summary, we optimized and evaluated the accuracy of an MR to CT deformable registration algorithm. The registered images constitute a useful 3D whole‐body MR‐CT atlas suitable for the development and evaluation of novel MR‐guided attenuation correction procedures on hybrid PET‐MR systems. PACS number: 07.05.Pj PMID:23835382

  15. Evaluation of whole-body MR to CT deformable image registration.

    Science.gov (United States)

    Akbarzadeh, A; Gutierrez, D; Baskin, A; Ay, M R; Ahmadian, A; Riahi Alam, N; Lövblad, K O; Zaidi, H

    2013-07-08

    Multimodality image registration plays a crucial role in various clinical and research applications. The aim of this study is to present an optimized MR to CT whole-body deformable image registration algorithm and its validation using clinical studies. A 3D intermodality registration technique based on B-spline transformation was performed using optimized parameters of the elastix package based on the Insight Toolkit (ITK) framework. Twenty-eight (17 male and 11 female) clinical studies were used in this work. The registration was evaluated using anatomical landmarks and segmented organs. In addition to 16 anatomical landmarks, three key organs (brain, lungs, and kidneys) and the entire body volume were segmented for evaluation. Several parameters--such as the Euclidean distance between anatomical landmarks, target overlap, Dice and Jaccard coefficients, false positives and false negatives, volume similarity, distance error, and Hausdorff distance--were calculated to quantify the quality of the registration algorithm. Dice coefficients for the majority of patients (> 75%) were in the 0.8-1 range for the whole body, brain, and lungs, which satisfies the criteria to achieve excellent alignment. On the other hand, for kidneys, Dice coefficients for volumes of 25% of the patients meet excellent volume agreement requirement, while the majority of patients satisfy good agreement criteria (> 0.6). For all patients, the distance error was in 0-10 mm range for all segmented organs. In summary, we optimized and evaluated the accuracy of an MR to CT deformable registration algorithm. The registered images constitute a useful 3D whole-body MR-CT atlas suitable for the development and evaluation of novel MR-guided attenuation correction procedures on hybrid PET-MR systems.

  16. Automated registration of diagnostic to prediagnostic x-ray mammograms: Evaluation and comparison to radiologists' accuracy

    International Nuclear Information System (INIS)

    Pinto Pereira, Snehal M.; Hipwell, John H.; McCormack, Valerie A.; Tanner, Christine; Moss, Sue M.; Wilkinson, Louise S.; Khoo, Lisanne A. L.; Pagliari, Catriona; Skippage, Pippa L.; Kliger, Carole J.; Hawkes, David J.; Santos Silva, Isabel M. dos

    2010-01-01

    Purpose: To compare and evaluate intensity-based registration methods for computation of serial x-ray mammogram correspondence. Methods: X-ray mammograms were simulated from MRIs of 20 women using finite element methods for modeling breast compressions and employing a MRI/x-ray appearance change model. The parameter configurations of three registration methods, affine, fluid, and free-form deformation (FFD), were optimized for registering x-ray mammograms on these simulated images. Five mammography film readers independently identified landmarks (tumor, nipple, and usually two other normal features) on pairs of diagnostic and corresponding prediagnostic digitized images from 52 breast cancer cases. Landmarks were independently reidentified by each reader. Target registration errors were calculated to compare the three registration methods using the reader landmarks as a gold standard. Data were analyzed using multilevel methods. Results: Between-reader variability varied with landmark (p<0.01) and screen (p=0.03), with between-reader mean distance (mm) in point location on the diagnostic/prediagnostic images of 2.50 (95% CI 1.95, 3.15)/2.84 (2.24, 3.55) for nipples and 4.26 (3.43, 5.24)/4.76 (3.85, 5.84) for tumors. Registration accuracy was sensitive to the type of landmark and the amount of breast density. For dense breasts (≥40%), the affine and fluid methods outperformed FFD. For breasts with lower density, the affine registration surpassed both fluid and FFD. Mean accuracy (mm) of the affine registration varied between 3.16 (95% CI 2.56, 3.90) for nipple points in breasts with density 20%-39% and 5.73 (4.80, 6.84) for tumor points in breasts with density <20%. Conclusions: Affine registration accuracy was comparable to that between independent film readers. More advanced two-dimensional nonrigid registration algorithms were incapable of increasing the accuracy of image alignment when compared to affine registration.

  17. Insecticides authorized for use on olive trees and the relationship between their registration and residues in olive oil

    Directory of Open Access Journals (Sweden)

    Lentza-Rizos, Ch.

    1996-12-01

    Full Text Available In order to eliminate losses due to insect attack, several insecticides are used on olive trees. Their residues in olive oil constitute an important parameter of its quality and must be monitored regularly and kept as low possible in order to ensure consumer protection. In this paper the insecticides authorized for use on olive trees are listed and their ADIs and Codex Alimentarius MRLs reported. The existing registrations are discussed from the point of view of their residues in oil.

    Diversos insecticidas son usados para eliminar las pérdidas debidas al ataque de insectos en olivos. Sus residuos en el aceite de oliva constituyen un parámetro importante de su calidad y deben ser controlados con regularidad y mantenidos tan bajos como sea posible en orden a asegurar la protección del consumidor. En este artículo se incluyen los distintos insecticidas autorizados para su uso en olivos así como los valores de ingesta diaria aceptable para el hombre y los límites máximos autorizados de los mismos. Los registros existentes se discuten desde el punto de vista de sus residuos en el aceite.

  18. Development and experimental evaluation of an automatic marker registration system for tracking of augmented reality

    International Nuclear Information System (INIS)

    Yan, Wei-da; Yang Shou-feng; Ishii, Hirotake; Shimoda, Hiroshi; Izumi, Masanori

    2010-01-01

    In order to apply augmented reality in plant maintenance activities it is necessary to use real-time high accuracy tracking technology. One of the most efficient tracking methods is using paper-based markers and computing the relative position and orientation between a vision sensor (camera) and the markers through image processing and geometry calculations. In this method, the 3D-position of each marker is needed before tracking, but it is inefficient to measure all the markers manually. In this study, an automatic marker registration system was developed so as to measure the 3D-position of each marker automatically. The system is composed of a camera, a laser rangefinder and a motion base, which is used to control the pose of the laser rangefinder. A computer, connected to them, is used for controlling the system and for data transport. The results of the experimental evaluations show that the measurement takes about 21 seconds per marker and that the Root Mean Square Error (RMSE) of the position measurements is 3.5 mm. The feasibility evaluation of the system was conducted in Fugen nuclear plant. The results show that the system can largely reduce the preparatory workload of an AR application in a Nuclear Power Plant (NPP). (author)

  19. Surface membrane based bladder registration for evaluation of accumulated dose during brachytherapy in cervical cancer

    DEFF Research Database (Denmark)

    Noe, Karsten Østergaard; Tanderup, Kari; Sørensen, Thomas Sangild

    2011-01-01

    of the fixed surface. Optional landmark based matches can be included in the suggested iterative solver. The technique is demonstrated for bladder registration in brachytherapy treatment evaluation of cervical cancer. It holds promise to better estimate the accumulated but unintentional dose delivered...

  20. Evaluation of linear registration algorithms for brain SPECT and the errors due to hypoperfusion lesions

    International Nuclear Information System (INIS)

    Radau, Perry E.; Slomka, Piotr J.; Julin, Per; Svensson, Leif; Wahlund, Lars-Olof

    2001-01-01

    The semiquantitative analysis of perfusion single-photon emission computed tomography (SPECT) images requires a reproducible, objective method. Automated spatial standardization (registration) of images is a prerequisite to this goal. A source of registration error is the presence of hypoperfusion defects, which was evaluated in this study with simulated lesions. The brain perfusion images measured by 99m Tc-HMPAO SPECT from 21 patients with probable Alzheimer's disease and 35 control subjects were retrospectively analyzed. An automatic segmentation method was developed to remove external activity. Three registration methods, robust least squares, normalized mutual information (NMI), and count difference were implemented and the effects of simulated defects were compared. The tested registration methods required segmentation of the cerebrum from external activity, and the automatic and manual methods differed by a three-dimensional displacement of 1.4±1.1 mm. NMI registration proved to be least adversely effected by simulated defects with 3 mm average displacement caused by severe defects. The error in quantifying the patient-template parietal ratio due to misregistration was 2.0% for large defects (70% hypoperfusion) and 0.5% for smaller defects (85% hypoperfusion)

  1. Mass preserving image registration

    DEFF Research Database (Denmark)

    Gorbunova, Vladlena; Sporring, Jon; Lo, Pechin Chien Pau

    2010-01-01

    The paper presents results the mass preserving image registration method in the Evaluation of Methods for Pulmonary Image Registration 2010 (EMPIRE10) Challenge. The mass preserving image registration algorithm was applied to the 20 image pairs. Registration was evaluated using four different...

  2. Performance Evaluation and Optimal Management of Distance-Based Registration Using a Semi-Markov Process

    Directory of Open Access Journals (Sweden)

    Jae Joon Suh

    2017-01-01

    Full Text Available We consider the distance-based registration (DBR which is a kind of dynamic location registration scheme in a mobile communication network. In the DBR, the location of a mobile station (MS is updated when it enters a base station more than or equal to a specified distance away from the base station where the location registration for the MS was done last. In this study, we first investigate the existing performance-evaluation methods on the DBR with implicit registration (DBIR presented to improve the performance of the DBR and point out some problems of the evaluation methods. We propose a new performance-evaluation method for the DBIR scheme using a semi-Markov process (SMP which can resolve the controversial issues of the existing methods. The numerical results obtained with the proposed SMP model are compared with those from previous models. It is shown that the SMP model should be considered to get an accurate performance of the DBIR scheme.

  3. Accuracy evaluation of initialization-free registration for intraoperative 3D-navigation

    International Nuclear Information System (INIS)

    Diakov, Georgi; Freysinger, Wolfgang

    2007-01-01

    Purpose An initialization-free approach for perioperative registration in functional endoscopic sinus surgery (FESS) is sought. The quality of surgical navigation relies on registration accuracy of preoperative images to the patient. Although landmark-based registration is fast, it is prone to human operator errors. This study evaluates the accuracy of two well-known methods for segmentation of the occipital bone from CT-images for use in surgical 3D-navigation. Method The occipital bone was segmented for registration without pre-defined correspondences, with the iterative closest point algorithm (ICP). The thresholding plus marching cubes segmentation (TMCS), and the deformable model segmentation (DMS) were compared quantitatively by overlaying the areas of the segmentations in cross-sectional slices, and visually by displaying the pointwise distances between the segmentations in a three-dimensional distance map relative to an expert manual segmentation, taken as a ''ground truth''. Results Excellent correspondence between the two methods was achieved; the results showed, however, that the TMCS is closer to the ''ground truth''. This is due to the sub-voxel accuracy of the marching cubes algorithm by definition, and the sensitivity of the DMS method to the choice of parameters. The DMS approach, as a gradient-based method, is insensitive to the thresholding initialization. For noisy images and soft tissue delineation a gradient-based method, like the deformable model, performs better. Both methods correspond within minute differences less than 4%. Conclusion These results will allow further minimization of human interaction in the planning phase for intraoperative 3D-navigation, by allowing to automatically create surface patches for registration purposes, ultimately allowing to build an initialization-free, fully automatic registration procedure for navigated Ear-, Nose-, Throat- (ENT) surgery. (orig.)

  4. Comparative study to evaluate the accuracy of polyether occlusal bite registration material and occlusal registration wax as a guide for occlusal reduction during tooth preparation

    Directory of Open Access Journals (Sweden)

    Niranjan Joshi

    2013-01-01

    Objective: The objective of this study was to compare and evaluate the reliability of the most commonly used occlusal registration wax that with polyether bite registration material as a guide for occlusal reduction required during tooth preparations. Materials and Methods: For the purpose of this study, 25 abutment teeth requiring tooth preparation for fixed prosthesis were selected and tooth preparations carried out. Modeling wax strips of specific dimensions were placed onto the cast of prepared tooth, which was mounted on maximum intercuspation on the articulator and the articulator was closed. The thickness of the wax registration was measured at three zones namely two functional cusps and central fossa. Similar measurements were made using the polyether bite registration material and prosthesis at the same zones. The data was tabulated and was subjected to statistical analysis using anova test and Tukey honestly significant difference test. Results: The differences in thickness between wax record and prosthesis by 0.1346 mm, whereas the difference between polyether and prosthesis was 0.02 mm with a P value of 0.042, which is statistically significant. This means that the wax record was 8.25% larger than the prosthesis while polyether was just 1.27% larger than the prosthesis. Conclusion: The clinical significance of the above analysis is that Ramitec polyether bite registration material is most suitable material when compared with commonly used modeling wax during the tooth preparation.

  5. Analysis of the utilization of existing test data for phase-in substance registration under the Act on the Registration and Evaluation, etc. of Chemical Substances.

    Science.gov (United States)

    Choi, Bong-In; Kwak, Yeong-Don; Jung, Yu-Mi; Ryu, Byung-Taek; Kim, Chang Gyun

    2015-01-01

    Approximately 2000 phase-in substances are subject to registration according to the Act on the Registration and Evaluation, etc. of Chemical Substances (KREACH), and the expected testing cost is 2.06 trillion Korean won assuming all the test data required for registration are acquired. The extent to which these enormous test costs can be reduced depends on the availability of existing data that can be used to meet the requirements of the K-REACH we examined the current availability of test data that can be used for chemical substance registration. We analyzed the possibility of utilizing the existing test data obtained from 16 reference databases for 369 of 518 kinds of phase-in substances subject to registration that were reported in last October 2014. The physical and chemical properties were available for 57.1% of substances, whereas data regarding human hazards and environmental hazards were available at considerably lower rates, 8.5% and 11.8%, respectively. Physical and chemical properties were available for a fairly high proportion, whereas human hazards and environmental hazards were reported for considerably fewer substances.

  6. Standard review plan for applications for sealed source and device evaluations and registrations

    International Nuclear Information System (INIS)

    1996-11-01

    The purpose of this document is to provide the reviewer of a request for a sealed source or device safety evaluation with the information and materials necessary to make a determination that the product is acceptable for licensing purposes. It provides the reviewer with a listing of the applicable regulations and industry standards, policies affecting evaluation and registration, certain administrative procedures to be followed, and information on how to perform the evaluation and write the registration certificate. Standard review plans are prepared for the guidance of the Office of Nuclear Material Safety and Safeguards staff responsible for the review of a sealed source or device application. This document is made available to the public as part of the Commission's policy to inform the nuclear industry and the general public of regulatory procedures and policies. Standard review plans are not substitutes for regulatory guides or the Commission's regulations and compliance with them is not required

  7. Standard review plan for applications for sealed source and device evaluations and registrations

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The purpose of this document is to provide the reviewer of a request for a sealed source or device safety evaluation with the information and materials necessary to make a determination that the product is acceptable for licensing purposes. It provides the reviewer with a listing of the applicable regulations and industry standards, policies affecting evaluation and registration, certain administrative procedures to be followed, and information on how to perform the evaluation and write the registration certificate. Standard review plans are prepared for the guidance of the Office of Nuclear Material Safety and Safeguards staff responsible for the review of a sealed source or device application. This document is made available to the public as part of the Commission`s policy to inform the nuclear industry and the general public of regulatory procedures and policies. Standard review plans are not substitutes for regulatory guides or the Commission`s regulations and compliance with them is not required.

  8. [The principle of registration, evaluation and testing of disinfecting preparations].

    Science.gov (United States)

    Röhm-Rodowald, Ewa; Jakimiak, Bozenna; Podgórska, Marta

    2008-01-01

    Disinfectants are used to produce a state in which the number of living micro-organisms has been reduced to a level which is appropriate to the practical situation. For any products which are included in the Biocidal Directive 98/8/EC, for which specific activity is claimed, test data has to be approved by the regulatory authority and a product license obtained before the product can be offered for sale. Disinfectants can be recorded as biocidal products or medical devices. Presently, it is possible to measure the activity of a product on defined micro-organisms in specified experimental conditions. Efficacy is the result of the use of a product according to a defined application. To allow different requirements in different areas of application, separate tests and pass criteria have been or will be prepared for each of following three areas of application: medical, veterinary and group comprising food, industrial, domestic and institutional areas. The laboratory methods to be used for testing the activity of chemical disinfectants meets the European standards. The tests are categorised on a modular basis as follows: phase 1 tests, phase 2 step 1 tests, phase 2 step 2 tests and phase 3 tests. In order to claim that a product has disinfectant properties, suitable for use in the medical area, the product shall be tested according to European standards: phase 2 step 1 tests, phase 2 step 2 tests. Phase 1 tests are not required to support claims for chemical disinfectants used in human medicine. Only phase 1 tests are required to support claims for active substances for which no particular area of application is specified. Medical devices are subjects to the European Directive 93/42/EEC which requires that a product must carry a CE mark. Disinfectants which are intended specifically by its manufacturer to be used on medical devices are themselves medical devices and so these products, as well as conforming to the instrument disinfection European standards as specified

  9. Anisotropic multi-scale fluid registration: evaluation in magnetic resonance breast imaging

    International Nuclear Information System (INIS)

    Crum, W R; Tanner, C; Hawkes, D J

    2005-01-01

    Registration using models of compressible viscous fluids has not found the general application of some other techniques (e.g., free-form-deformation (FFD)) despite its ability to model large diffeomorphic deformations. We report on a multi-resolution fluid registration algorithm which improves on previous work by (a) directly solving the Navier-Stokes equation at the resolution of the images (b) accommodating image sampling anisotropy using semi-coarsening and implicit smoothing in a full multi-grid (FMG) solver and (c) exploiting the inherent multi-resolution nature of FMG to implement a multi-scale approach. Evaluation is on five magnetic resonance (MR) breast images subject to six biomechanical deformation fields over 11 multi-resolution schemes. Quantitative assessment is by tissue overlaps and target registration errors and by registering using the known correspondences rather than image features to validate the fluid model. Context is given by comparison with a validated FFD algorithm and by application to images of volunteers subjected to large applied deformation. The results show that fluid registration of 3D breast MR images to sub-voxel accuracy is possible in minutes on a 1.6 GHz Linux-based Athlon processor with coarse solutions obtainable in a few tens of seconds. Accuracy and computation time are comparable to FFD techniques validated for this application

  10. Registration of 3D ultrasound computer tomography and MRI for evaluation of tissue correspondences

    Science.gov (United States)

    Hopp, T.; Dapp, R.; Zapf, M.; Kretzek, E.; Gemmeke, H.; Ruiter, N. V.

    2015-03-01

    3D Ultrasound Computer Tomography (USCT) is a new imaging method for breast cancer diagnosis. In the current state of development it is essential to correlate USCT with a known imaging modality like MRI to evaluate how different tissue types are depicted. Due to different imaging conditions, e.g. with the breast subject to buoyancy in USCT, a direct correlation is demanding. We present a 3D image registration method to reduce positioning differences and allow direct side-by-side comparison of USCT and MRI volumes. It is based on a two-step approach including a buoyancy simulation with a biomechanical model and free form deformations using cubic B-Splines for a surface refinement. Simulation parameters are optimized patient-specifically in a simulated annealing scheme. The method was evaluated with in-vivo datasets resulting in an average registration error below 5mm. Correlating tissue structures can thereby be located in the same or nearby slices in both modalities and three-dimensional non-linear deformations due to the buoyancy are reduced. Image fusion of MRI volumes and USCT sound speed volumes was performed for intuitive display. By applying the registration to data of our first in-vivo study with the KIT 3D USCT, we could correlate several tissue structures in MRI and USCT images and learn how connective tissue, carcinomas and breast implants observed in the MRI are depicted in the USCT imaging modes.

  11. Comparative study to evaluate the accuracy of polyether occlusal bite registration material and occlusal registration wax as a guide for occlusal reduction during tooth preparation.

    Science.gov (United States)

    Joshi, Niranjan; Shetty, Sridhar N; Prasad, Krishna D

    2013-01-01

    The use of different materials and techniques has been studied to decide the safest quantum of reduction of the occlusal surfaces. However, these methods provide limited information as to the actual amount of reduction with limitations in accuracy, accessibility and complexity. The objective of this study was to compare and evaluate the reliability of the most commonly used occlusal registration wax that with polyether bite registration material as a guide for occlusal reduction required during tooth preparations. For the purpose of this study, 25 abutment teeth requiring tooth preparation for fixed prosthesis were selected and tooth preparations carried out. Modeling wax strips of specific dimensions were placed onto the cast of prepared tooth, which was mounted on maximum intercuspation on the articulator and the articulator was closed. The thickness of the wax registration was measured at three zones namely two functional cusps and central fossa. Similar measurements were made using the polyether bite registration material and prosthesis at the same zones. The data was tabulated and was subjected to statistical analysis using anova test and Tukey honestly significant difference test. The differences in thickness between wax record and prosthesis by 0.1346 mm, whereas the difference between polyether and prosthesis was 0.02 mm with a P value of 0.042, which is statistically significant. This means that the wax record was 8.25% larger than the prosthesis while polyether was just 1.27% larger than the prosthesis. The clinical significance of the above analysis is that Ramitec polyether bite registration material is most suitable material when compared with commonly used modeling wax during the tooth preparation.

  12. Evaluation of registration strategies for multi-modality images of rat brain slices

    International Nuclear Information System (INIS)

    Palm, Christoph; Vieten, Andrea; Salber, Dagmar; Pietrzyk, Uwe

    2009-01-01

    In neuroscience, small-animal studies frequently involve dealing with series of images from multiple modalities such as histology and autoradiography. The consistent and bias-free restacking of multi-modality image series is obligatory as a starting point for subsequent non-rigid registration procedures and for quantitative comparisons with positron emission tomography (PET) and other in vivo data. Up to now, consistency between 2D slices without cross validation using an inherent 3D modality is frequently presumed to be close to the true morphology due to the smooth appearance of the contours of anatomical structures. However, in multi-modality stacks consistency is difficult to assess. In this work, consistency is defined in terms of smoothness of neighboring slices within a single modality and between different modalities. Registration bias denotes the distortion of the registered stack in comparison to the true 3D morphology and shape. Based on these metrics, different restacking strategies of multi-modality rat brain slices are experimentally evaluated. Experiments based on MRI-simulated and real dual-tracer autoradiograms reveal a clear bias of the restacked volume despite quantitatively high consistency and qualitatively smooth brain structures. However, different registration strategies yield different inter-consistency metrics. If no genuine 3D modality is available, the use of the so-called SOP (slice-order preferred) or MOSOP (modality-and-slice-order preferred) strategy is recommended.

  13. Automated registration of diagnostic to prediagnostic x-ray mammograms: Evaluation and comparison to radiologists' accuracy

    Energy Technology Data Exchange (ETDEWEB)

    Pinto Pereira, Snehal M.; Hipwell, John H.; McCormack, Valerie A.; Tanner, Christine; Moss, Sue M.; Wilkinson, Louise S.; Khoo, Lisanne A. L.; Pagliari, Catriona; Skippage, Pippa L.; Kliger, Carole J.; Hawkes, David J.; Santos Silva, Isabel M. dos [Cancer Research UK Epidemiology and Genetics Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT (United Kingdom); Centre for Medical Image Computing, University College London, London WC1E 6BT (United Kingdom); Lifestyle and Cancer Group, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69008 (France); Centre for Medical Image Computing, University College London, London WC1E 6BT (United Kingdom); Cancer Screening Evaluation Unit, Institute of Cancer Research, Surrey SM2 5NG (United Kingdom); St. George' s Healthcare NHS Trust and South West London Breast Screening Service, London SW17 0QT (United Kingdom); Centre for Medical Image Computing, University College London, London WC1E 6BT (United Kingdom); Cancer Research UK Epidemiology and Genetics Group, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT (United Kingdom)

    2010-09-15

    Purpose: To compare and evaluate intensity-based registration methods for computation of serial x-ray mammogram correspondence. Methods: X-ray mammograms were simulated from MRIs of 20 women using finite element methods for modeling breast compressions and employing a MRI/x-ray appearance change model. The parameter configurations of three registration methods, affine, fluid, and free-form deformation (FFD), were optimized for registering x-ray mammograms on these simulated images. Five mammography film readers independently identified landmarks (tumor, nipple, and usually two other normal features) on pairs of diagnostic and corresponding prediagnostic digitized images from 52 breast cancer cases. Landmarks were independently reidentified by each reader. Target registration errors were calculated to compare the three registration methods using the reader landmarks as a gold standard. Data were analyzed using multilevel methods. Results: Between-reader variability varied with landmark (p<0.01) and screen (p=0.03), with between-reader mean distance (mm) in point location on the diagnostic/prediagnostic images of 2.50 (95% CI 1.95, 3.15)/2.84 (2.24, 3.55) for nipples and 4.26 (3.43, 5.24)/4.76 (3.85, 5.84) for tumors. Registration accuracy was sensitive to the type of landmark and the amount of breast density. For dense breasts ({>=}40%), the affine and fluid methods outperformed FFD. For breasts with lower density, the affine registration surpassed both fluid and FFD. Mean accuracy (mm) of the affine registration varied between 3.16 (95% CI 2.56, 3.90) for nipple points in breasts with density 20%-39% and 5.73 (4.80, 6.84) for tumor points in breasts with density <20%. Conclusions: Affine registration accuracy was comparable to that between independent film readers. More advanced two-dimensional nonrigid registration algorithms were incapable of increasing the accuracy of image alignment when compared to affine registration.

  14. A reference dataset for deformable image registration spatial accuracy evaluation using the COPDgene study archive

    International Nuclear Information System (INIS)

    Castillo, Richard; Castillo, Edward; Wood, Abbie M; Ludwig, Michelle S; Guerrero, Thomas; Fuentes, David; Ahmad, Moiz

    2013-01-01

    Landmark point-pairs provide a strategy to assess deformable image registration (DIR) accuracy in terms of the spatial registration of the underlying anatomy depicted in medical images. In this study, we propose to augment a publicly available database (www.dir-lab.com) of medical images with large sets of manually identified anatomic feature pairs between breath-hold computed tomography (BH-CT) images for DIR spatial accuracy evaluation. Ten BH-CT image pairs were randomly selected from the COPDgene study cases. Each patient had received CT imaging of the entire thorax in the supine position at one-fourth dose normal expiration and maximum effort full dose inspiration. Using dedicated in-house software, an imaging expert manually identified large sets of anatomic feature pairs between images. Estimates of inter- and intra-observer spatial variation in feature localization were determined by repeat measurements of multiple observers over subsets of randomly selected features. 7298 anatomic landmark features were manually paired between the 10 sets of images. Quantity of feature pairs per case ranged from 447 to 1172. Average 3D Euclidean landmark displacements varied substantially among cases, ranging from 12.29 (SD: 6.39) to 30.90 (SD: 14.05) mm. Repeat registration of uniformly sampled subsets of 150 landmarks for each case yielded estimates of observer localization error, which ranged in average from 0.58 (SD: 0.87) to 1.06 (SD: 2.38) mm for each case. The additions to the online web database (www.dir-lab.com) described in this work will broaden the applicability of the reference data, providing a freely available common dataset for targeted critical evaluation of DIR spatial accuracy performance in multiple clinical settings. Estimates of observer variance in feature localization suggest consistent spatial accuracy for all observers across both four-dimensional CT and COPDgene patient cohorts. (paper)

  15. An evaluation of approaches used to teach quality improvement to pre-registration healthcare professionals: An integrative review.

    Science.gov (United States)

    Armstrong, Lorraine; Shepherd, Ashley; Harris, Fiona

    2017-08-01

    Improving the quality of healthcare remains central to UK and international policy, practice and research. In 2003, The Institute of Medicine's 'Health Professions Education: A Bridge to Quality', advocated quality improvement as a core competency for all healthcare professionals. As a result, developing capacity and capability of those applying improvement methodologies in the pre-registration population has risen, yet, little is known about the teaching approaches employed for this purpose. To describe and analyse educational approaches used to teach quality improvement to pre-registration healthcare professionals and identify enabling and impeding factors. Integrative review. CINAHL, PsychINFO, MEDLINE, ERIC, ASSIA, SCOPUS and Google Scholar were accessed for papers published between 2000 and 2016. Publications where quality improvement education was delivered to pre-registration healthcare professionals were eligible. One author independently screened papers, extracted data using a modified version of the Reporting of Primary Studies in Education Guideline and evaluated methodological quality using the Weight of Evidence Framework. The Kirkpatrick Education Evaluation Model was used to explore the impact of teaching approaches. Enabling and impeding factors were thematically analysed. A narrative synthesis of findings is presented. Ten papers were included, representing nursing, pharmacy and medicine from UK, Norway and USA. Studies comprised four quantitative, four mixed method, one qualitative and one cluster randomised trial, all allocated medium Weight of Evidence. Teaching approaches included experiential learning cited in all studies, didactics in seven, group work in four, seminars in three, self-directed learning in three and simulation in one. Most studies measured Level 1 of the Kirkpatrick Model (reaction), all but one measured Level 2 (skills, knowledge or attitudes), none measured Level 3 (behaviour) and one measured Level 4 (patient outcomes

  16. Evaluation of whole-body MR to CT deformable image registration

    NARCIS (Netherlands)

    Akbarzadeh, A.; Gutierrez, D.; Baskin, A.; Ay, M. R.; Ahmadian, A.; Alam, N. Riahi; Loevblad, K. O.; Zaidi, H.

    2013-01-01

    Multimodality image registration plays a crucial role in various clinical and research applications. The aim of this study is to present an optimized MR to CT whole-body deformable image registration algorithm and its validation using clinical studies. A 3D intermodality registration technique based

  17. Geo-registration of Unprofessional and Weakly-related Image and Precision Evaluation

    Directory of Open Access Journals (Sweden)

    LIU Yingzhen

    2015-09-01

    Full Text Available The 3D geo-spatial model built by unprofessional and weakly-related image is a significant source of geo-spatial information. The unprofessional and weakly-related image cannot be useful geo-spatial information until be geo-registered with accurate geo-spatial orientation and location. In this paper, we present an automatic geo-registration using the coordination acquired by real-time GPS module. We calculate 2D and 3D spatial transformation parameters based on the spatial similarity between the image location in the geo-spatial coordination system and in the 3D reconstruction coordination system. Because of the poor precision of GPS information and especially the unstability of elevation measurement, we use RANSAC algorithm to get rid of outliers. In the experiment, we compare the geo-registered image positions to their differential GPS coordinates. The errors of translation, rotation and scaling are evaluated quantitively and the causes of bad result are analyzed. The experiment demonstrates that this geo-registration method can get a precise result with enough images.

  18. Evaluation of the apparent losses caused by water meter under-registration in intermittent water supply.

    Science.gov (United States)

    Criminisi, A; Fontanazza, C M; Freni, G; Loggia, G La

    2009-01-01

    Apparent losses are usually caused by water theft, billing errors, or revenue meter under-registration. While the first two causes are directly related to water utility management and may be reduced by improving company procedures, water meter inaccuracies are considered to be the most significant and hardest to quantify. Water meter errors are amplified in networks subjected to water scarcity, where users adopt private storage tanks to cope with the intermittent water supply. The aim of this paper is to analyse the role of two variables influencing the apparent losses: water meter age and the private storage tank effect on meter performance. The study was carried out in Palermo (Italy). The impact of water meter ageing was evaluated in laboratory by testing 180 revenue meters, ranging from 0 to 45 years in age. The effects of the private water tanks were determined via field monitoring of real users and a mathematical model. This study demonstrates that the impact on apparent losses from the meter starting flow rapidly increases with meter age. Private water tanks, usually fed by a float valve, overstate meter under-registration, producing additional apparent losses between 15% and 40% for the users analysed in this study.

  19. SU-E-J-112: Intensity-Based Pulmonary Image Registration: An Evaluation Study

    Energy Technology Data Exchange (ETDEWEB)

    Yang, F; Meyer, J; Sandison, G [Department of Radiation Oncology, University of Washington Medical Center, Seattle, WA (United States)

    2015-06-15

    Purpose: Accurate alignment of thoracic CT images is essential for dose tracking and to safely implement adaptive radiotherapy in lung cancers. At the same time it is challenging given the highly elastic nature of lung tissue deformations. The objective of this study was to assess the performances of three state-of-art intensity-based algorithms in terms of their ability to register thoracic CT images subject to affine, barrel, and sinusoid transformation. Methods: Intensity similarity measures of the evaluated algorithms contained sum-of-squared difference (SSD), local mutual information (LMI), and residual complexity (RC). Five thoracic CT scans obtained from the EMPIRE10 challenge database were included and served as reference images. Each CT dataset was distorted by realistic affine, barrel, and sinusoid transformations. Registration performances of the three algorithms were evaluated for each distortion type in terms of intensity root mean square error (IRMSE) between the reference and registered images in the lung regions. Results: For affine distortions, the three algorithms differed significantly in registration of thoracic images both visually and nominally in terms of IRMSE with a mean of 0.011 for SSD, 0.039 for RC, and 0.026 for LMI (p<0.01; Kruskal-Wallis test). For barrel distortion, the three algorithms showed nominally no significant difference in terms of IRMSE with a mean of 0.026 for SSD, 0.086 for RC, and 0.054 for LMI (p=0.16) . A significant difference was seen for sinusoid distorted thoracic CT data with mean lung IRMSE of 0.039 for SSD, 0.092 for RC, and 0.035 for LMI (p=0.02). Conclusion: Pulmonary deformations might vary to a large extent in nature in a daily clinical setting due to factors ranging from anatomy variations to respiratory motion to image quality. It can be appreciated from the results of the present study that the suitability of application of a particular algorithm for pulmonary image registration is deformation-dependent.

  20. New York Power Authority`s energy-efficient refigerator program for the New York City Housing Authority - savings evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Pratt, R.G.; Miller, J.D.

    1997-09-01

    The New York Power Authority (NYPA) and the New York City Housing Authority (NYCHA) are replacing refrigerators in New York City public housing with new, highly energy-efficient models over a five-year period. This report describes the analysis of the energy cost savings achieved through the replacement of 20,000 refrigerators in 1996, the first year of the NYPA/NYCHA program. The NYPA/NYCHA project serves as the lynchpin of a larger program designed to offer energy-efficient appliances to housing authorities across the country. The national program is a partnership between the U.S. Department of Energy (DOE) and the Consortium for Energy Efficiency (CEE). Starting with the 1997 refrigerator contract, this program invites other housing authorities to join NYPA in its volume purchase of energy-efficient refrigerators, at the same price and terms available to NYPA. Through these volume purchases, DOE`s ENERGY STAR{reg_sign} Partnerships program hopes to encourage appliance manufacturers to bring more efficient appliances to the market and to provide volume purchasers with the per-unit price savings of a bulk purchaser. DOE asked the Pacific Northwest National Laboratory (PNNL) to establish a protocol for evaluating the savings achieved with the NYPA refrigerators. That protocol is summarized in this report.

  1. An evaluation of a public health practitioner registration programme: lessons learned for workforce development.

    Science.gov (United States)

    Rahman, Em; Wills, Jane

    2014-09-01

    This article explores the lessons learned for workforce development from an evaluation of a regional programme to support the assessment and registration of public health practitioners to the UK Public Health Register (UKPHR) in England. A summative and process evaluation of the public health practitioner programme in Wessex was adopted. Data collection was by an online survey of 32 public health practitioners in the Wessex area and semi-structured interviews with 53 practitioners, programme support, employers and system leaders. All survey respondents perceived regulation of the public health workforce as very important or important. Managers and system leaders saw a register of those fit to practise and able to define themselves as a public health practitioner as a necessary assurance of quality for the public. Yet, because registration is voluntary for practitioners, less value was currently placed on this than on completing a master's qualification. The local programme supports practitioners in the compilation of a retrospective portfolio of evidence that demonstrates fitness to practise; practitioners and managers stated that this does not support current and future learning needs or the needs of those working at a senior level. One of the main purposes of statutory regulation of professionals is to protect the public by an assurance of fitness to practise where there is a potential for harm. The widening role for public health practitioners without any regulation means that there is the risk of inappropriate interventions or erroneous advice. Regulators, policy makers and system leaders need to consider how they can support the development of the public health workforce to gain professional recognition at all levels of public health, including practitioners alongside specialists, and support a professional career framework for the public health system. © Royal Society for Public Health 2014.

  2. Novel image registration quality evaluator (RQE) with an implementation for automated patient positioning in cranial radiation therapy

    International Nuclear Information System (INIS)

    Wu Jian; Samant, Sanjiv S.

    2007-01-01

    In external beam radiation therapy, digitally reconstructed radiographs (DRRs) and portal images are used to verify patient setup based either on a visual comparison or, less frequently, with automated registration algorithms. A registration algorithm can be trapped in local optima due to irregularity of patient anatomy, image noise and artifacts, and/ or out-of-plane shifts, resulting in an incorrect solution. Thus, human observation, which is subjective, is still required to check the registration result. We propose to use a novel image registration quality evaluator (RQE) to automatically identify misregistrations as part of an algorithm-based decision-making process for verification of patient positioning. A RQE, based on an adaptive pattern classifier, is generated from a pair of reference and target images to determine the acceptability of a registration solution given an optimization process. Here we applied our RQE to patient positioning for cranial radiation therapy. We constructed two RQEs--one for the evaluation of intramodal registrations (i.e., portal-portal); the other for intermodal registrations (i.e., portal-DRR). Mutual information, because of its high discriminatory ability compared with other measures (i.e., correlation coefficient and partitioned intensity uniformity), was chosen as the test function for both RQEs. We adopted 1 mm translation and 1 deg. rotation as the maximal acceptable registration errors, reflecting desirable clinical setup tolerances for cranial radiation therapy. Receiver operating characteristic analysis was used to evaluate the performance of the RQE, including computations of sensitivity and specificity. The RQEs showed very good performance for both intramodal and intermodal registrations using simulated and phantom data. The sensitivity and the specificity were 0.973 and 0.936, respectively, for the intramodal RQE using phantom data. Whereas the sensitivity and the specificity were 0.961 and 0.758, respectively, for

  3. [History of the evaluation of medicines aiming for marketing authorization].

    Science.gov (United States)

    Caulin, C

    2008-01-01

    The European Directive on Medicines Evaluation and Marketing Authorization were issued in 1975. For more than 30 years, Marketing Authorization criteria have been defined as pharmaceutical and biological quality, therapeutic efficacy, and safety. The application comes from the pharmaceutical company and must include the full data on drug development. French procedures have always included practical assessment of the drug by health practitioners: clinicians, pharmacists, biologists, and specialists in biostatistics.

  4. 78 FR 8522 - Chlorpyrifos Registration Review; Preliminary Evaluation of the Potential Risk From...

    Science.gov (United States)

    2013-02-06

    ... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2008-0850; FRL-9376-5] Chlorpyrifos Registration... preliminary volatilization assessment for the registration review of chlorpyrifos and opens a public comment... assessment for chlorpyrifos uses. After reviewing comments received during the public comment period, EPA...

  5. Third molar development: evaluation of nine tooth development registration techniques for age estimations.

    Science.gov (United States)

    Thevissen, Patrick W; Fieuws, Steffen; Willems, Guy

    2013-03-01

    Multiple third molar development registration techniques exist. Therefore the aim of this study was to detect which third molar development registration technique was most promising to use as a tool for subadult age estimation. On a collection of 1199 panoramic radiographs the development of all present third molars was registered following nine different registration techniques [Gleiser, Hunt (GH); Haavikko (HV); Demirjian (DM); Raungpaka (RA); Gustafson, Koch (GK); Harris, Nortje (HN); Kullman (KU); Moorrees (MO); Cameriere (CA)]. Regression models with age as response and the third molar registration as predictor were developed for each registration technique separately. The MO technique disclosed highest R(2) (F 51%, M 45%) and lowest root mean squared error (F 3.42 years; M 3.67 years) values, but differences with other techniques were small in magnitude. The amount of stages utilized in the explored staging techniques slightly influenced the age predictions. © 2013 American Academy of Forensic Sciences.

  6. Process Evaluation of a School-Based Education Program about Organ Donation and Registration, and the Intention for Continuance

    Science.gov (United States)

    Reubsaet, A.; Reinaerts, E. B. M.; Brug, J.; van Hooff, J. P.; van den Borne, H. W.

    2004-01-01

    This paper describes the process evaluation of an organ donation education program for high school students aged 15-18 years of which the effectiveness was established. The program consisted of three components: a video with group discussion, an interactive computer-tailored program and a registration training session. A cross-sectional survey was…

  7. Evaluating Industry Payments Among Dermatology Clinical Practice Guidelines Authors.

    Science.gov (United States)

    Checketts, Jake X; Sims, Matthew Thomas; Vassar, Matt

    2017-12-01

    It is well documented that financial conflicts of interest influence medical research and clinical practice. Prior to the Open Payments provisions of the Affordable Care Act, financial ties became apparent only through self-disclosure. The nature of financial interests has not been studied among physicians who develop dermatology clinical practice guidelines. To evaluate payments received by physicians who author dermatology clinical practice guidelines, compare disclosure statements for accuracy, determine whether pharmaceutical companies from which the authors received payments manufactured products related to the guidelines, and examine the extent to which the American Academy of Dermatology enforced their Administrative Regulations for guideline development. Three American Academy of Dermatology guidelines published from 2013 to 2016 were retrieved. Double data extraction was used to record financial payments received by 49 guideline authors using the Open Payments database. Payments received by the authors from the date of the initial literature search to the date of publication were used to evaluate disclosure statement accuracy, detail the companies providing payments, and evaluate Administrative Regulations enforcement. This study is applicable to clinical practice guideline panels drafting recommendations, physicians using clinical practice guidelines to inform patient care, and those establishing policies for guideline development. Our main outcomes are the monetary values and types of payments received by physicians who author dermatology guidelines and the accuracy of disclosure statements. Data were collected from the Open Payments database and analyzed descriptively. Of the 49 authors evaluated, 40 received at least 1 reported industry payment, 31 accepted more than $1000, 25 accepted more than $10 000, and 18 accepted more than $50 000. Financial payments amounted to a mean of $157 177 per author. The total reimbursement among the 49 authors

  8. Generation and evaluation of 3D digital casts of maxillary defects based on multisource data registration: A pilot clinical study.

    Science.gov (United States)

    Ye, Hongqiang; Ma, Qijun; Hou, Yuezhong; Li, Man; Zhou, Yongsheng

    2017-12-01

    Digital techniques are not clinically applied for 1-piece maxillary prostheses containing an obturator and removable partial denture retained by the remaining teeth because of the difficulty in obtaining sufficiently accurate 3-dimensional (3D) images. The purpose of this pilot clinical study was to generate 3D digital casts of maxillary defects, including the defective region and the maxillary dentition, based on multisource data registration and to evaluate their effectiveness. Twelve participants with maxillary defects were selected. The maxillofacial region was scanned with spiral computer tomography (CT), and the maxillary arch and palate were scanned using an intraoral optical scanner. The 3D images from the CT and intraoral scanner were registered and merged to form a 3D digital cast of the maxillary defect containing the anatomic structures needed for the maxillary prosthesis. This included the defect cavity, maxillary dentition, and palate. Traditional silicone impressions were also made, and stone casts were poured. The accuracy of the digital cast in comparison with that of the stone cast was evaluated by measuring the distance between 4 anatomic landmarks. Differences and consistencies were assessed using paired Student t tests and the intraclass correlation coefficient (ICC). In 3 participants, physical resin casts were produced by rapid prototyping from digital casts. Based on the resin casts, maxillary prostheses were fabricated by using conventional methods and then evaluated in the participants to assess the clinical applicability of the digital casts. Digital casts of the maxillary defects were generated and contained all the anatomic details needed for the maxillary prosthesis. Comparing the digital and stone casts, a paired Student t test indicated that differences in the linear distances between landmarks were not statistically significant (P>.05). High ICC values (0.977 to 0.998) for the interlandmark distances further indicated the high

  9. Study of different registration methods for on-line kilovoltage cone-beam CT guided lung cancer radiation

    International Nuclear Information System (INIS)

    Wang Yanyang; Fu Xiaolong; Xia Bing; Wu Zhengqin; Fan Min; Yang Huanjun; Xu Zhiyong; Jiang Guoliang

    2009-01-01

    Objective: To select the optimal registration method for on-line kilovoltage cone-beam CT (KVCBCT) guided lung cancer radiation and evaluate the reproducibility of the selected method. Methods: Sixteen patients with non-small cell lung cancer were enrolled into this study. A total of 96 pretreatment KVCBCT images from the 16 patients were available for the analysis. Image registration methods were bone-based automatic registration, gray-based automatic registration, manual registration and semi-automatic registration. All registrations were accomplished by one physician. Another physician blindly evaluated the results of each registration, then selected the optimal registration method and evaluated its reproducibility. Results: The average score of the bone-based automatic registration, gray-based automatic registration, manual registration and semi-automatic registration methods was 2.4, 2.7, 3.0 and 3.7, respectively. The score of the four different groups had statistics significant difference (F=42.20, P<0.001). Using the semi-automatic registration method, the probability of the difference between two registration results more than 3 mm in the left-right, superior-inferior, and anterior-posterior directions was 0, 3% and 6% by the same physician, 0, 14% and 0 by different physicians, and 8%, 14% and 8% by physician and radiation therapist. Conclusions: Semi-automatic registration method, possessing the highest score and accepted reproducibility, is appropriate for KVCBCT guided lung cancer radiation. (authors)

  10. Improving alignment in Tract-based spatial statistics: evaluation and optimization of image registration

    NARCIS (Netherlands)

    de Groot, Marius; Vernooij, Meike W.; Klein, Stefan; Ikram, M. Arfan; Vos, Frans M.; Smith, Stephen M.; Niessen, Wiro J.; Andersson, Jesper L. R.

    2013-01-01

    Anatomical alignment in neuroimaging studies is of such importance that considerable effort is put into improving the registration used to establish spatial correspondence. Tract-based spatial statistics (TBSS) is a popular method for comparing diffusion characteristics across subjects. TBSS

  11. Improving alignment in Tract-based spatial statistics : Evaluation and optimization of image registration

    NARCIS (Netherlands)

    De Groot, M.; Vernooij, M.W.; Klein, S.; Arfan Ikram, M.; Vos, F.M.; Smith, S.M.; Niessen, W.J.; Andersson, J.L.R.

    2013-01-01

    Anatomical alignment in neuroimaging studies is of such importance that considerable effort is put into improving the registration used to establish spatial correspondence. Tract-based spatial statistics (TBSS) is a popular method for comparing diffusion characteristics across subjects. TBSS

  12. Evaluation of body-wise and organ-wise registrations for abdominal organs

    Science.gov (United States)

    Xu, Zhoubing; Panjwani, Sahil A.; Lee, Christopher P.; Burke, Ryan P.; Baucom, Rebeccah B.; Poulose, Benjamin K.; Abramson, Richard G.; Landman, Bennett A.

    2016-03-01

    Identifying cross-sectional and longitudinal correspondence in the abdomen on computed tomography (CT) scans is necessary for quantitatively tracking change and understanding population characteristics, yet abdominal image registration is a challenging problem. The key difficulty in solving this problem is huge variations in organ dimensions and shapes across subjects. The current standard registration method uses the global or body-wise registration technique, which is based on the global topology for alignment. This method (although producing decent results) has substantial influence of outliers, thus leaving room for significant improvement. Here, we study a new image registration approach using local (organ-wise registration) by first creating organ-specific bounding boxes and then using these regions of interest (ROIs) for aligning references to target. Based on Dice Similarity Coefficient (DSC), Mean Surface Distance (MSD) and Hausdorff Distance (HD), the organ-wise approach is demonstrated to have significantly better results by minimizing the distorting effects of organ variations. This paper compares exclusively the two registration methods by providing novel quantitative and qualitative comparison data and is a subset of the more comprehensive problem of improving the multi-atlas segmentation by using organ normalization.

  13. Evaluation of Scientific Journal Validity, It's Articles and Their Authors.

    Science.gov (United States)

    Masic, Izet; Begic, Edin

    2016-01-01

    The science that deals with evaluation of a scientific article refer to the finding quantitative indicators (index) of the scientific research success is called scientometrics. Scientometrics is part of scientology (the science of science) that analyzes scientific papers and their citations in a selected sample of scientific journals. There are four indexes by which it is possible to measure the validity of scientific research: number of articles, impact factor of the journal, the number and order of authors and citations number. Every scientific article is a record of the data written by the rules recommended by several scientific associations and committees. Growing number of authors and lot of authors with same name and surname led to the introduction of the necessary identification agent - ORCID number.

  14. Rationale and design of the PREDICT (Plaque Registration and Evaluation Detected In Computed Tomography) registry.

    Science.gov (United States)

    Yamamoto, Hideya; Awai, Kazuo; Kuribayashi, Sachio; Kihara, Yasuki

    2014-01-01

    At least two-thirds of cases of acute coronary syndrome are caused by disruption of an atherosclerotic plaque. The natural history of individual plaques is unknown and needs to be established. The Plaque Registration and Evaluation Detected In Computed Tomography (PREDICT) registry is a prospective, multicenter, longitudinal, observational registry. This registry was designed to examine the relationships among coronary CT angiography (CTA) findings and clinical findings, mortality, and morbidity. The relationships among progression of coronary atherosclerosis, including changes in plaque characteristics on coronary CTA, and serum lipid levels and modification of coronary risk factors will also be evaluated. From October 2009 to December 2012, 3015 patients who underwent coronary CTA in 29 centers in Japan were enrolled. These patients were followed for 2 years. The primary end points were considered as all-cause mortality and major cardiac events, including cardiac death, nonfatal myocardial infarction, and unstable angina that required hospitalization. The secondary end points were heart failure that required administration of diuretics, target vessel revascularization, cerebral infarction, peripheral arterial disease, and invasive coronary angiography. Blood pressure, serum lipid, and C-reactive protein levels and all cardiovascular events were recorded at 1 and 2 years. If the initial coronary CTA showed any stenosis or plaques, follow-up coronary CTA was scheduled at 2 years to determine changes in coronary lesions, including changes in plaque characteristics. Analysis of the PREDICT registry data will clarify the relationships between coronary CTA findings and cardiovascular mortality and morbidity in a collaborative multicenter fashion. This trial is registered at www.clinicaltrials.gov as NCT 00991835. Copyright © 2014 Society of Cardiovascular Computed Tomography. All rights reserved.

  15. The evaluation of composite dose using deformable image registration in adaptive radiotherapy for head and neck cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, Chul Hwan; Ko, Seong Jin; Kim, Chang Soo; Kim, Jung Hoon; Kim, Dong Hyun; Choi, Seok Yoon; Ye, Soo Young; Kang, Se Sik [Dept. of Radiological Science, College of Health Sciences, Catholic University of Pusan, Pusan (Korea, Republic of)

    2013-09-15

    In adaptive radiotherapy(ART), generated composite dose of surrounding normal tissue on overall treatment course which is using deformable image registration from multistage images. Also, compared with doses summed by each treatment plan and clinical significance is considered. From the first of May, 2011 to the last of July, 2012. Patients who were given treatment and had the head and neck cancer with 3-dimension conformal radiotherapy or intensity modulated radiotherapy, those who were carried out adaptive radiotherapy cause of tumor shrinkage and weight loss. Generated composite dose of surrounding normal tissue using deformable image registration was been possible, statistically significant difference was showed to mandible(48.95±3.89 vs 49.10±3.55 Gy), oral cavity(36.93±4.03 vs 38.97±5.08 Gy), parotid gland(35.71±6.22 vs 36.12±6.70 Gy) and temporomandibular joint(18.41±9.60 vs 20.13±10.42 Gy) compared with doses summed by each treatment plan. The results of this study show significant difference between composite dose by deformable image registration and doses summed by each treatment plan, composite dose by deformable image registration may generate more exact evaluation to surrounding normal tissue in adaptive radiotherapy.

  16. The evaluation of composite dose using deformable image registration in adaptive radiotherapy for head and neck cancer

    International Nuclear Information System (INIS)

    Hwang, Chul Hwan; Ko, Seong Jin; Kim, Chang Soo; Kim, Jung Hoon; Kim, Dong Hyun; Choi, Seok Yoon; Ye, Soo Young; Kang, Se Sik

    2013-01-01

    In adaptive radiotherapy(ART), generated composite dose of surrounding normal tissue on overall treatment course which is using deformable image registration from multistage images. Also, compared with doses summed by each treatment plan and clinical significance is considered. From the first of May, 2011 to the last of July, 2012. Patients who were given treatment and had the head and neck cancer with 3-dimension conformal radiotherapy or intensity modulated radiotherapy, those who were carried out adaptive radiotherapy cause of tumor shrinkage and weight loss. Generated composite dose of surrounding normal tissue using deformable image registration was been possible, statistically significant difference was showed to mandible(48.95±3.89 vs 49.10±3.55 Gy), oral cavity(36.93±4.03 vs 38.97±5.08 Gy), parotid gland(35.71±6.22 vs 36.12±6.70 Gy) and temporomandibular joint(18.41±9.60 vs 20.13±10.42 Gy) compared with doses summed by each treatment plan. The results of this study show significant difference between composite dose by deformable image registration and doses summed by each treatment plan, composite dose by deformable image registration may generate more exact evaluation to surrounding normal tissue in adaptive radiotherapy

  17. Evaluating the Usability of a Controlled Language Authoring Assistant

    Directory of Open Access Journals (Sweden)

    Miyata Rei

    2017-06-01

    Full Text Available This paper presents experimental results of a usability evaluation of a controlled language (CL authoring assistant designed to help non-professional writers create machine translatable source texts. As the author drafts the text, the system detects CL rule violations and proscribed terms. It also incorporates several support functions to facilitate rephrasing of the source. In order to assess the usability of the system, we conducted a rewriting experiment, in which we compared two groups of participants, one with the aid of the system and the other without it. The results revealed that our system helped reduce the number of CL violations by about 9% and the time to correct violations by more than 30%. The CL-applied source text resulted in higher fluency and adequacy of MT outputs. Questionnaire and interview results also implied the improved satisfaction with the task completion of those participants who used the system.

  18. An evaluation of post-registration neuroscience focused education and neuroscience nurses' perceived educational needs.

    Science.gov (United States)

    Braine, Mary E; Cook, Neal

    2015-11-01

    People with complex neurological conditions require co-ordinated care provided by nurses educated in meeting service needs, understanding the pathophysiological processes of disease and the preparation to care for those with complex needs. However, evidence suggests that neuroscience specific education provision is largely unregulated and set outside of a cohesive professional development context. Furthermore, it largely seems to only address the induction phase into working within neurosciences. To evaluate the nature of post-registration neuroscience focused education across Europe and neuroscience nurses' perceived educational needs. Post qualifying nurses working in the field of neurosciences were invited to complete a self-reported 29-item on-line questionnaire that contained closed and open-ended questions exploring professional background, clinical and educational experience, educational opportunities available to them and their perspectives on their educational needs. 154 participants from fourteen countries across Europe completed the survey. 75% (n=110) of respondents had undertaken neuroscience focused education with the most accessible education opportunities found to be conferences 77% (n=96) and study days 69% (n=86). Overall, 52.6% of courses were multidisciplinary in nature, and 47.4% were exclusively nursing. Most identified that their courses were funded by their employer (57%, n=63) or partly funded by their employer. Results illustrate a significant variance across Europe, highlighting the need for more effective communication between neuroscience nurses across Europe. Implications for future education provision, recruitment/retention, and funding are discussed, resulting in recommendations for the future of neuroscience nursing. This study, the largest of its kind to survey neuroscience nurses, illustrates the absence of a cohesive career development pathway for neuroscience nurses in Europe. Nurses need quality assured specialist education to

  19. Registration Service

    CERN Multimedia

    GS Department

    2010-01-01

    Following a reorganization in Building 55, please note that the Registration Service is now organised as follows :  Ground floor: access cards (76903). 1st floor : registration of external firms’ personnel (76611 / 76622); car access stickers (76633); biometric registration (79710). Opening hours: 07-30 to 16-00 non-stop. GS-SEM Group General Infrastructure Services Department

  20. Four-dimensional dose evaluation using deformable image registration in radiotherapy for liver cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hoon Jung, Sang; Min Yoon, Sang; Ho Park, Sung; Cho, Byungchul; Won Park, Jae; Jung, Jinhong; Park, Jin-hong; Hoon Kim, Jong; Do Ahn, Seung [Departments of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 138-736 (Korea, Republic of)

    2013-01-15

    Purpose: In order to evaluate the dosimetric impact of respiratory motion on the dose delivered to the target volume and critical organs during free-breathing radiotherapy, a four-dimensional dose was evaluated using deformable image registration (DIR). Methods: Four-dimensional computed tomography (4DCT) images were acquired for 11 patients who were treated for liver cancer. Internal target volume-based treatment planning and dose calculation (3D dose) were performed using the end-exhalation phase images. The four-dimensional dose (4D dose) was calculated based on DIR of all phase images from 4DCT to the planned image. Dosimetric parameters from the 4D dose, were calculated and compared with those from the 3D dose. Results: There was no significant change of the dosimetric parameters for gross tumor volume (p > 0.05). The increase D{sub mean} and generalized equivalent uniform dose (gEUD) for liver were by 3.1%{+-} 3.3% (p= 0.003) and 2.8%{+-} 3.3% (p= 0.008), respectively, and for duodenum, they were decreased by 15.7%{+-} 11.2% (p= 0.003) and 15.1%{+-} 11.0% (p= 0.003), respectively. The D{sub max} and gEUD for stomach was decreased by 5.3%{+-} 5.8% (p= 0.003) and 9.7%{+-} 8.7% (p= 0.003), respectively. The D{sub max} and gEUD for right kidney was decreased by 11.2%{+-} 16.2% (p= 0.003) and 14.9%{+-} 16.8% (p= 0.005), respectively. For left kidney, D{sub max} and gEUD were decreased by 11.4%{+-} 11.0% (p= 0.003) and 12.8%{+-} 12.1% (p= 0.005), respectively. The NTCP values for duodenum and stomach were decreased by 8.4%{+-} 5.8% (p= 0.003) and 17.2%{+-} 13.7% (p= 0.003), respectively. Conclusions: The four-dimensional dose with a more realistic dose calculation accounting for respiratory motion revealed no significant difference in target coverage and potentially significant change in the physical and biological dosimetric parameters in normal organs during free-breathing treatment.

  1. Evaluation of optimization methods for nonrigid medical image registration using mutual information and B-splines

    NARCIS (Netherlands)

    Klein, S.; Staring, M.; Pluim, J.P.W.

    2007-01-01

    A popular technique for nonrigid registration of medical images is based on the maximization of their mutual information, in combination with a deformation field parameterized by cubic B-splines. The coordinate mapping that relates the two images is found using an iterative optimization procedure.

  2. Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration

    International Nuclear Information System (INIS)

    Lee, Choonik; Langen, Katja M.; Lu, Weiguo; Haimerl, Jason; Schnarr, Eric; Ruchala, Kenneth J.; Olivera, Gustavo H.; Meeks, Sanford L.; Kupelian, Patrick A.; Shellenberger, Thomas D.; Manon, Rafael R.

    2008-01-01

    Background and purpose: To assess and evaluate geometrical changes in parotid glands using deformable image registration and megavoltage CT (MVCT) images. Methods: A deformable registration algorithm was applied to 330 daily MVCT images (10 patients) to create deformed parotid contours. The accuracy and robustness of the algorithm was evaluated through visual review, comparison with manual contours, and precision analysis. Temporal changes in the parotid gland geometry were observed. Results: The deformed parotid contours were qualitatively judged to be acceptable. Compared with manual contours, the uncertainties of automatically deformed contours were similar with regard to geometry and dosimetric endpoint. The day-to-day variations (1 standard deviation of errors) in the center-of-mass distance and volume were 1.61 mm and 4.36%, respectively. The volumes tended to decrease with a median total loss of 21.3% (6.7-31.5%) and a median change rate of 0.7%/day (0.4-1.3%/day). Parotids migrated toward the patient center with a median total distance change of -5.26 mm (0.00 to -16.35 mm) and a median change rate of -0.22 mm/day (0.02 to -0.56 mm/day). Conclusion: The deformable image registration and daily MVCT images provide an efficient and reliable assessment of parotid changes over the course of a radiation therapy

  3. TU-F-17A-03: A 4D Lung Phantom for Coupled Registration/Segmentation Evaluation

    International Nuclear Information System (INIS)

    Markel, D; El Naqa, I; Levesque, I

    2014-01-01

    Purpose: Coupling the processes of segmentation and registration (regmentation) is a recent development that allows improved efficiency and accuracy for both steps and may improve the clinical feasibility of online adaptive radiotherapy. Presented is a multimodality animal tissue model designed specifically to provide a ground truth to simultaneously evaluate segmentation and registration errors during respiratory motion. Methods: Tumor surrogates were constructed from vacuum sealed hydrated natural sea sponges with catheters used for the injection of PET radiotracer. These contained two compartments allowing for two concentrations of radiotracer mimicking both tumor and background signals. The lungs were inflated to different volumes using an air pump and flow valve and scanned using PET/CT and MRI. Anatomical landmarks were used to evaluate the registration accuracy using an automated bifurcation tracking pipeline for reproducibility. The bifurcation tracking accuracy was assessed using virtual deformations of 2.6 cm, 5.2 cm and 7.8 cm of a CT scan of a corresponding human thorax. Bifurcations were detected in the deformed dataset and compared to known deformation coordinates for 76 points. Results: The bifurcation tracking accuracy was found to have a mean error of −0.94, 0.79 and −0.57 voxels in the left-right, anterior-posterior and inferior-superior axes using a 1×1×5 mm3 resolution after the CT volume was deformed 7.8 cm. The tumor surrogates provided a segmentation ground truth after being registered to the phantom image. Conclusion: A swine lung model in conjunction with vacuum sealed sponges and a bifurcation tracking algorithm is presented that is MRI, PET and CT compatible and anatomically and kinetically realistic. Corresponding software for tracking anatomical landmarks within the phantom shows sub-voxel accuracy. Vacuum sealed sponges provide realistic tumor surrogate with a known boundary. A ground truth with minimal uncertainty is thus

  4. TU-AB-202-06: Quantitative Evaluation of Deformable Image Registration in MRI-Guided Adaptive Radiation Therapy

    International Nuclear Information System (INIS)

    Mooney, K; Zhao, T; Green, O; Mutic, S; Yang, D; Duan, Y; Zhang, M

    2016-01-01

    Purpose: To assess the performance of the deformable image registration algorithm used for MRI-guided adaptive radiation therapy using image feature analysis. Methods: MR images were collected from five patients treated on the MRIdian (ViewRay, Inc., Oakwood Village, OH), a three head Cobalt-60 therapy machine with an 0.35 T MR system. The images were acquired immediately prior to treatment with a uniform 1.5 mm resolution. Treatment sites were as follows: head/neck, lung, breast, stomach, and bladder. Deformable image registration was performed using the ViewRay software between the first fraction MRI and the final fraction MRI, and the DICE similarity coefficient (DSC) for the skin contours was reported. The SIFT and Harris feature detection and matching algorithms identified point features in each image separately, then found matching features in the other image. The target registration error (TRE) was defined as the vector distance between matched features on the two image sets. Each deformation was evaluated based on comparison of average TRE and DSC. Results: Image feature analysis produced between 2000–9500 points for evaluation on the patient images. The average (± standard deviation) TRE for all patients was 3.3 mm (±3.1 mm), and the passing rate of TRE<3 mm was 60% on the images. The head/neck patient had the best average TRE (1.9 mm±2.3 mm) and the best passing rate (80%). The lung patient had the worst average TRE (4.8 mm±3.3 mm) and the worst passing rate (37.2%). DSC was not significantly correlated with either TRE (p=0.63) or passing rate (p=0.55). Conclusions: Feature matching provides a quantitative assessment of deformable image registration, with a large number of data points for analysis. The TRE of matched features can be used to evaluate the registration of many objects throughout the volume, whereas DSC mainly provides a measure of gross overlap. We have a research agreement with ViewRay Inc.

  5. TU-AB-202-06: Quantitative Evaluation of Deformable Image Registration in MRI-Guided Adaptive Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Mooney, K; Zhao, T; Green, O; Mutic, S; Yang, D [Washington University School of Medicine, Saint Louis, MO (United States); Duan, Y [University of Missouri, Columbia, Missouri (United States); Zhang, M [Oregon Health and Science University, Portland, Oregon (United States)

    2016-06-15

    Purpose: To assess the performance of the deformable image registration algorithm used for MRI-guided adaptive radiation therapy using image feature analysis. Methods: MR images were collected from five patients treated on the MRIdian (ViewRay, Inc., Oakwood Village, OH), a three head Cobalt-60 therapy machine with an 0.35 T MR system. The images were acquired immediately prior to treatment with a uniform 1.5 mm resolution. Treatment sites were as follows: head/neck, lung, breast, stomach, and bladder. Deformable image registration was performed using the ViewRay software between the first fraction MRI and the final fraction MRI, and the DICE similarity coefficient (DSC) for the skin contours was reported. The SIFT and Harris feature detection and matching algorithms identified point features in each image separately, then found matching features in the other image. The target registration error (TRE) was defined as the vector distance between matched features on the two image sets. Each deformation was evaluated based on comparison of average TRE and DSC. Results: Image feature analysis produced between 2000–9500 points for evaluation on the patient images. The average (± standard deviation) TRE for all patients was 3.3 mm (±3.1 mm), and the passing rate of TRE<3 mm was 60% on the images. The head/neck patient had the best average TRE (1.9 mm±2.3 mm) and the best passing rate (80%). The lung patient had the worst average TRE (4.8 mm±3.3 mm) and the worst passing rate (37.2%). DSC was not significantly correlated with either TRE (p=0.63) or passing rate (p=0.55). Conclusions: Feature matching provides a quantitative assessment of deformable image registration, with a large number of data points for analysis. The TRE of matched features can be used to evaluate the registration of many objects throughout the volume, whereas DSC mainly provides a measure of gross overlap. We have a research agreement with ViewRay Inc.

  6. 3D-2D registration in endovascular image-guided surgery: evaluation of state-of-the-art methods on cerebral angiograms.

    Science.gov (United States)

    Mitrović, Uroš; Likar, Boštjan; Pernuš, Franjo; Špiclin, Žiga

    2018-02-01

    Image guidance for minimally invasive surgery is based on spatial co-registration and fusion of 3D pre-interventional images and treatment plans with the 2D live intra-interventional images. The spatial co-registration or 3D-2D registration is the key enabling technology; however, the performance of state-of-the-art automated methods is rather unclear as they have not been assessed under the same test conditions. Herein we perform a quantitative and comparative evaluation of ten state-of-the-art methods for 3D-2D registration on a public dataset of clinical angiograms. Image database consisted of 3D and 2D angiograms of 25 patients undergoing treatment for cerebral aneurysms or arteriovenous malformations. On each of the datasets, highly accurate "gold-standard" registrations of 3D and 2D images were established based on patient-attached fiducial markers. The database was used to rigorously evaluate ten state-of-the-art 3D-2D registration methods, namely two intensity-, two gradient-, three feature-based and three hybrid methods, both for registration of 3D pre-interventional image to monoplane or biplane 2D images. Intensity-based methods were most accurate in all tests (0.3 mm). One of the hybrid methods was most robust with 98.75% of successful registrations (SR) and capture range of 18 mm for registrations of 3D to biplane 2D angiograms. In general, registration accuracy was similar whether registration of 3D image was performed onto mono- or biplanar 2D images; however, the SR was substantially lower in case of 3D to monoplane 2D registration. Two feature-based and two hybrid methods had clinically feasible execution times in the order of a second. Performance of methods seems to fall below expectations in terms of robustness in case of registration of 3D to monoplane 2D images, while translation into clinical image guidance systems seems readily feasible for methods that perform registration of the 3D pre-interventional image onto biplanar intra

  7. Quantitative evaluation of an image registration method for a NIPAM gel dosimeter

    International Nuclear Information System (INIS)

    Chang, Yuan-Jen; Yao, Chun-Hsu; Wu, Jay; Hsieh, Bor-Tsung; Tsang, Yuk-Wah; Chen, Chin-Hsing

    2015-01-01

    One of the problems in obtaining quality results is image registration when a gel dosimeter is used in conjunction with optical computed tomography (CT). This study proposes a passive alignment mechanism to obtain a precisely measured dose map. A holder plate with two pin–hole pairs is placed on the gel container cap. These two pin–hole pairs attach the gel container to the vertical shaft and can be precisely aligned with the rotation center of the vertical shaft at any time. Accordingly, a better reconstructed image quality is obtained. After obtaining a precisely measured dose map, the scale invariant feature transform (SIFT)-flow algorithm is utilized as an image registration method to align the treatment plan software (TPS) image with the measured dose map image. The results show that the gamma pass rate for the single-field irradiation increases from 83.39% to 94.03% when the algorithm is applied. And the gamma pass rate for the five-field irradiation treatment plan increases from 87.36% to 94.34%. The translation, scaling, and rotation occurring in the dose map image constructed using an optical CT scanner are also aligned with those in the TPS image using the SIFT-flow algorithm. Accordingly, improved gamma comparison results and a higher gamma pass rate are obtained. - Highlights: • A passive alignment method for obtaining a precisely measured dose map is developed. • The SIFT-flow algorithm is adopted as an image registration method for the gel dosimeter. • The SIFT-flow algorithm increases the gamma pass rate from 83.39% to 94.03% for the single-field irradiation. • The SIFT-flow algorithm increases the gamma pass rate from 87.36% to 94.34% for the five-field irradiation. • The translation, scaling, and rotation in the measured dose map image are aligned with those in the TPS image using the SIFT-flow algorithm

  8. Quantitative evaluation of an image registration method for a NIPAM gel dosimeter

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Yuan-Jen [Department of Management Information Systems, Central Taiwan University of Science and Technology, No. 666, Buzih Rd., Beitun District, Taichung City, Taiwan (R.O.C.) (China); Institute of Biomedical Engineering and Materials Science, Central Taiwan University of Science and Technology, No. 666, Buzih Rd., Beitun District, Taichung City, Taiwan (R.O.C.) (China); Yao, Chun-Hsu [School of Chinese Medicine, China Medical University, Taichung, Taiwan (R.O.C.) (China); Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan (R.O.C.) (China); Department of Biomedical Informatics, Asia University, Taichung, Taiwan (R.O.C.) (China); Wu, Jay [Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan (R.O.C.) (China); Hsieh, Bor-Tsung [Department of Biomedical Imaging and Radiological Sciences, Central Taiwan University of Science and Technology, Taichung, Taiwan (R.O.C.) (China); Tsang, Yuk-Wah [Department of Radiation Oncology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan (R.O.C.) (China); Chen, Chin-Hsing [Department of Management Information Systems, Central Taiwan University of Science and Technology, No. 666, Buzih Rd., Beitun District, Taichung City, Taiwan (R.O.C.) (China)

    2015-06-01

    One of the problems in obtaining quality results is image registration when a gel dosimeter is used in conjunction with optical computed tomography (CT). This study proposes a passive alignment mechanism to obtain a precisely measured dose map. A holder plate with two pin–hole pairs is placed on the gel container cap. These two pin–hole pairs attach the gel container to the vertical shaft and can be precisely aligned with the rotation center of the vertical shaft at any time. Accordingly, a better reconstructed image quality is obtained. After obtaining a precisely measured dose map, the scale invariant feature transform (SIFT)-flow algorithm is utilized as an image registration method to align the treatment plan software (TPS) image with the measured dose map image. The results show that the gamma pass rate for the single-field irradiation increases from 83.39% to 94.03% when the algorithm is applied. And the gamma pass rate for the five-field irradiation treatment plan increases from 87.36% to 94.34%. The translation, scaling, and rotation occurring in the dose map image constructed using an optical CT scanner are also aligned with those in the TPS image using the SIFT-flow algorithm. Accordingly, improved gamma comparison results and a higher gamma pass rate are obtained. - Highlights: • A passive alignment method for obtaining a precisely measured dose map is developed. • The SIFT-flow algorithm is adopted as an image registration method for the gel dosimeter. • The SIFT-flow algorithm increases the gamma pass rate from 83.39% to 94.03% for the single-field irradiation. • The SIFT-flow algorithm increases the gamma pass rate from 87.36% to 94.34% for the five-field irradiation. • The translation, scaling, and rotation in the measured dose map image are aligned with those in the TPS image using the SIFT-flow algorithm.

  9. Authority, Autonomy, and Deception: Evaluating the Legitimacy of Parental Authority and Adolescent Deceit.

    Science.gov (United States)

    Gingo, Matthew; Roded, Alona D; Turiel, Elliot

    2017-12-01

    This research examined adolescents' judgments about lying to avoid parental control over different types of activities. Participants (N = 66, M age  = 16.38, 73% European American) were interviewed about hypothetical situations describing adolescents who defied parental directives and lied about their defiance. Judgments about the legitimacy of parents' directives and protagonists' deception differed by types of parent relationship with adolescents (mutual or unilateral). Directives were least accepted, and deception was most accepted, in the context of unilateral relationships. Judgments also differed by domain of the action (personal, prudential, or conventional). Participants were least accepting of parental directives, and most accepting of deception about personal activities. Findings indicate that adolescents value honesty and parental authority, but sometimes give priority to concerns with autonomy and mutuality. © 2017 The Authors. Journal of Research on Adolescence © 2017 Society for Research on Adolescence.

  10. An automated, quantitative, and case-specific evaluation of deformable image registration in computed tomography images

    Science.gov (United States)

    Kierkels, R. G. J.; den Otter, L. A.; Korevaar, E. W.; Langendijk, J. A.; van der Schaaf, A.; Knopf, A. C.; Sijtsema, N. M.

    2018-02-01

    A prerequisite for adaptive dose-tracking in radiotherapy is the assessment of the deformable image registration (DIR) quality. In this work, various metrics that quantify DIR uncertainties are investigated using realistic deformation fields of 26 head and neck and 12 lung cancer patients. Metrics related to the physiologically feasibility (the Jacobian determinant, harmonic energy (HE), and octahedral shear strain (OSS)) and numerically robustness of the deformation (the inverse consistency error (ICE), transitivity error (TE), and distance discordance metric (DDM)) were investigated. The deformable registrations were performed using a B-spline transformation model. The DIR error metrics were log-transformed and correlated (Pearson) against the log-transformed ground-truth error on a voxel level. Correlations of r  ⩾  0.5 were found for the DDM and HE. Given a DIR tolerance threshold of 2.0 mm and a negative predictive value of 0.90, the DDM and HE thresholds were 0.49 mm and 0.014, respectively. In conclusion, the log-transformed DDM and HE can be used to identify voxels at risk for large DIR errors with a large negative predictive value. The HE and/or DDM can therefore be used to perform automated quality assurance of each CT-based DIR for head and neck and lung cancer patients.

  11. Quantitative evaluation of an image registration method for a NIPAM gel dosimeter

    Science.gov (United States)

    Chang, Yuan-Jen; Yao, Chun-Hsu; Wu, Jay; Hsieh, Bor-Tsung; Tsang, Yuk-Wah; Chen, Chin-Hsing

    2015-06-01

    One of the problems in obtaining quality results is image registration when a gel dosimeter is used in conjunction with optical computed tomography (CT). This study proposes a passive alignment mechanism to obtain a precisely measured dose map. A holder plate with two pin-hole pairs is placed on the gel container cap. These two pin-hole pairs attach the gel container to the vertical shaft and can be precisely aligned with the rotation center of the vertical shaft at any time. Accordingly, a better reconstructed image quality is obtained. After obtaining a precisely measured dose map, the scale invariant feature transform (SIFT)-flow algorithm is utilized as an image registration method to align the treatment plan software (TPS) image with the measured dose map image. The results show that the gamma pass rate for the single-field irradiation increases from 83.39% to 94.03% when the algorithm is applied. And the gamma pass rate for the five-field irradiation treatment plan increases from 87.36% to 94.34%. The translation, scaling, and rotation occurring in the dose map image constructed using an optical CT scanner are also aligned with those in the TPS image using the SIFT-flow algorithm. Accordingly, improved gamma comparison results and a higher gamma pass rate are obtained.

  12. MO-C-17A-13: Uncertainty Evaluation of CT Image Deformable Registration for H and N Cancer Adaptive Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Qin, A; Yan, D [William Beaumont Hospital, Royal Oak, MI (United States)

    2014-06-15

    Purpose: To evaluate uncertainties of organ specific Deformable Image Registration (DIR) for H and N cancer Adaptive Radiation Therapy (ART). Methods: A commercial DIR evaluation tool, which includes a digital phantom library of 8 patients, and the corresponding “Ground truth Deformable Vector Field” (GT-DVF), was used in the study. Each patient in the phantom library includes the GT-DVF created from a pair of CT images acquired prior to and at the end of the treatment course. Five DIR tools, including 2 commercial tools (CMT1, CMT2), 2 in-house (IH-FFD1, IH-FFD2), and a classic DEMON algorithms, were applied on the patient images. The resulting DVF was compared to the GT-DVF voxel by voxel. Organ specific DVF uncertainty was calculated for 10 ROIs: Whole Body, Brain, Brain Stem, Cord, Lips, Mandible, Parotid, Esophagus and Submandibular Gland. Registration error-volume histogram was constructed for comparison. Results: The uncertainty is relatively small for brain stem, cord and lips, while large in parotid and submandibular gland. CMT1 achieved best overall accuracy (on whole body, mean vector error of 8 patients: 0.98±0.29 mm). For brain, mandible, parotid right, parotid left and submandibular glad, the classic Demon algorithm got the lowest uncertainty (0.49±0.09, 0.51±0.16, 0.46±0.11, 0.50±0.11 and 0.69±0.47 mm respectively). For brain stem, cord and lips, the DVF from CMT1 has the best accuracy (0.28±0.07, 0.22±0.08 and 0.27±0.12 mm respectively). All algorithms have largest right parotid uncertainty on patient #7, which has image artifact caused by tooth implantation. Conclusion: Uncertainty of deformable CT image registration highly depends on the registration algorithm, and organ specific. Large uncertainty most likely appears at the location of soft-tissue organs far from the bony structures. Among all 5 DIR methods, the classic DEMON and CMT1 seem to be the best to limit the uncertainty within 2mm for all OARs. Partially supported by

  13. Evaluating the Usability of Authoring Environments for Serious Games.

    Science.gov (United States)

    Slootmaker, Aad; Hummel, Hans; Koper, Rob

    2017-08-01

    Background . The EMERGO method and online platform enable the development and delivery of scenario-based serious games that foster students to acquire professional competence. One of the main goals of the platform is to provide a user-friendly authoring environment for creating virtual environments where students can perform authentic tasks. Aim . We present the findings of an in-depth qualitative case study of the platform's authoring environment and compare our findings on usability with those found for comparable environments in literature. Method . We carried out semi-structured interviews, with two experienced game developers who have authored a game for higher education, and a literature review of comparable environments. Findings . The analysis shows that the usability of the authoring environment is problematic, especially regarding understandability and learnability , which is in line with findings of comparable environments. Other findings are that authoring is well integrated with the EMERGO method and that functionality and reliability of the authoring environment are valued. Practical implications . The lessons learned are presented in the form of general guidelines to improve the understandability and learnability of authoring environments for serious games .

  14. SU-E-J-222: Evaluation of Deformable Registration of PET/CT Images for Cervical Cancer Brachytherapy

    International Nuclear Information System (INIS)

    Liao, Y; Turian, J; Templeton, A; Kiel, K; Chu, J; Kadir, T

    2014-01-01

    Purpose: PET/CT provides important functional information for radiotherapy targeting of cervical cancer. However, repeated PET/CT procedures for external beam and subsequent brachytherapy expose patients to additional radiation and are not cost effective. Our goal is to investigate the possibility of propagating PET-active volumes for brachytherapy procedures through deformable image registration (DIR) of earlier PET/CT and ultimately to minimize the number of PET/CT image sessions required. Methods: Nine cervical cancer patients each received their brachytherapy preplanning PET/CT at the end of EBRT with a Syed template in place. The planning PET/CT was acquired on the day of brachytherapy treatment with the actual applicator (Syed or Tandem and Ring) and rigidly registered. The PET/CT images were then deformably registered creating a third (deformed) image set for target prediction. Regions of interest with standardized uptake values (SUV) greater than 65% of maximum SUV were contoured as target volumes in all three sets of PET images. The predictive value of the registered images was evaluated by comparing the preplanning and deformed PET volumes with the planning PET volume using Dice's coefficient (DC) and center-of-mass (COM) displacement. Results: The average DCs were 0.12±0.14 and 0.19±0.16 for rigid and deformable predicted target volumes, respectively. The average COM displacements were 1.9±0.9 cm and 1.7±0.7 cm for rigid and deformable registration, respectively. The DCs were improved by deformable registration, however, both were lower than published data for DIR in other modalities and clinical sites. Anatomical changes caused by different brachytherapy applicators could have posed a challenge to the DIR algorithm. The physiological change from interstitial needle placement may also contribute to lower DC. Conclusion: The clinical use of DIR in PET/CT for cervical cancer brachytherapy appears to be limited by applicator choice and requires further

  15. Registration of the cancer

    International Nuclear Information System (INIS)

    Morales, F.; Campos, X.

    2002-01-01

    A database for the registration of the cancer was designed in ambient access, of the Microsoft Office, to take the registrations at national level. With this database the statistics will be obtained about the incidence of the cancer in the population, evaluation of the sanitary services of prevention, diagnose and treatment of the illness, etc. The used codes are according to the listings of code of the Ministry of Health (MINSA) and OPS

  16. Estimation of lung motion fields in 4D CT data by variational non-linear intensity-based registration: A comparison and evaluation study

    International Nuclear Information System (INIS)

    Werner, René; Schmidt-Richberg, Alexander; Handels, Heinz; Ehrhardt, Jan

    2014-01-01

    Accurate and robust estimation of motion fields in respiration-correlated CT (4D CT) images, usually performed by non-linear registration of the temporal CT frames, is a precondition for the analysis of patient-specific breathing dynamics and subsequent image-supported diagnostics and treatment planning. In this work, we present a comprehensive comparison and evaluation study of non-linear registration variants applied to the task of lung motion estimation in thoracic 4D CT data. In contrast to existing multi-institutional comparison studies (e.g. MIDRAS and EMPIRE10), we focus on the specific but common class of variational intensity-based non-parametric registration and analyze the impact of the different main building blocks of the underlying optimization problem: the distance measure to be minimized, the regularization approach and the transformation space considered during optimization. In total, 90 different combinations of building block instances are compared. Evaluated on proprietary and publicly accessible 4D CT images, landmark-based registration errors (TRE) between 1.14 and 1.20 mm for the most accurate registration variants demonstrate competitive performance of the applied general registration framework compared to other state-of-the-art approaches for lung CT registration. Although some specific trends can be observed, effects of interchanging individual instances of the building blocks on the TRE are in general rather small (no single outstanding registration variant existing); the same level of accuracy is, however, associated with significantly different degrees of motion field smoothness and computational demands. Consequently, the building block combination of choice will depend on application-specific requirements on motion field characteristics. (paper)

  17. Implementing service improvement projects within pre-registration nursing education: a multi-method case study evaluation.

    Science.gov (United States)

    Baillie, Lesley; Bromley, Barbara; Walker, Moira; Jones, Rebecca; Mhlanga, Fortune

    2014-01-01

    Preparing healthcare students for quality and service improvement is important internationally. A United Kingdom (UK) initiative aims to embed service improvement in pre-registration education. A UK university implemented service improvement teaching for all nursing students. In addition, the degree pathway students conducted service improvement projects as the basis for their dissertations. The study aimed to evaluate the implementation of service improvement projects within a pre-registration nursing curriculum. A multi-method case study was conducted, using student questionnaires, focus groups with students and academic staff, and observation of action learning sets. Questionnaire data were analysed using SPSS v19. Qualitative data were analysed using Ritchie and Spencer's (1994) Framework Approach. Students were very positive about service improvement. The degree students, who conducted service improvement projects in practice, felt more knowledgeable than advanced diploma students. Selecting the project focus was a key issue and students encountered some challenges in practice. Support for student service improvement projects came from action learning sets, placement staff, and academic staff. Service improvement projects had a positive effect on students' learning. An effective partnership between the university and partner healthcare organisations, and support for students in practice, is essential. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. A posteriori registration and subtraction of periapical radiographs for the evaluation of external apical root resorption after orthodontic treatment.

    Science.gov (United States)

    Kreich, Eliane Maria; Chibinski, Ana Cláudia; Coelho, Ulisses; Wambier, Letícia Stadler; Zedebski, Rosário de Arruda Moura; de Moraes, Mari Eli Leonelli; de Moraes, Luiz Cesar

    2016-03-01

    This study employed a posteriori registration and subtraction of radiographic images to quantify the apical root resorption in maxillary permanent central incisors after orthodontic treatment, and assessed whether the external apical root resorption (EARR) was related to a range of parameters involved in the treatment. A sample of 79 patients (mean age, 13.5±2.2 years) with no history of trauma or endodontic treatment of the maxillary permanent central incisors was selected. Periapical radiographs taken before and after orthodontic treatment were digitized and imported to the Regeemy software. Based on an analysis of the posttreatment radiographs, the length of the incisors was measured using Image J software. The mean EARR was described in pixels and relative root resorption (%). The patient's age and gender, tooth extraction, use of elastics, and treatment duration were evaluated to identify possible correlations with EARR. The mean EARR observed was 15.44±12.1 pixels (5.1% resorption). No differences in the mean EARR were observed according to patient characteristics (gender, age) or treatment parameters (use of elastics, treatment duration). The only parameter that influenced the mean EARR of a patient was the need for tooth extraction. A posteriori registration and subtraction of periapical radiographs was a suitable method to quantify EARR after orthodontic treatment, and the need for tooth extraction increased the extent of root resorption after orthodontic treatment.

  19. A posterior registration and subtraction of periapical radiographs for the evaluation of external apical root resorption after orthodontic treatment

    Energy Technology Data Exchange (ETDEWEB)

    Kreich, Eliane Maria; Chibinski, Ana Claudia; Coelho, Ulisses; Wambier, Leticia Stadler; Zedebski, Rosaio De Arruda Moura [School of Dentistry, Ponta Grossa State University, Ponta Grossa, Parana (Brazil); De Moraes, Mari Eli Leonelli; De Moraes, Luiz Cesar [Dept. of Dental Radiology, School of Dentistry, State University of Sao Paulo, Sao Jose dos Campos, Sao Paulo (Brazil)

    2016-03-15

    This study employed a posteriori registration and subtraction of radiographic images to quantify the apical root resorption in maxillary permanent central incisors after orthodontic treatment, and assessed whether the external apical root resorption (EARR) was related to a range of parameters involved in the treatment. A sample of 79 patients (mean age, 13.5±2.2 years) with no history of trauma or endodontic treatment of the maxillary permanent central incisors was selected. Periapical radiographs taken before and after orthodontic treatment were digitized and imported to the Regeemy software. Based on an analysis of the posttreatment radiographs, the length of the incisors was measured using Image J software. The mean EARR was described in pixels and relative root resorption (%). The patient's age and gender, tooth extraction, use of elastics, and treatment duration were evaluated to identify possible correlations with EARR. The mean EARR observed was 15.44±12.1 pixels (5.1% resorption). No differences in the mean EARR were observed according to patient characteristics (gender, age) or treatment parameters (use of elastics, treatment duration). The only parameter that influenced the mean EARR of a patient was the need for tooth extraction. A posteriori registration and subtraction of periapical radiographs was a suitable method to quantify EARR after orthodontic treatment, and the need for tooth extraction increased the extent of root resorption after orthodontic treatment.

  20. A posterior registration and subtraction of periapical radiographs for the evaluation of external apical root resorption after orthodontic treatment

    International Nuclear Information System (INIS)

    Kreich, Eliane Maria; Chibinski, Ana Claudia; Coelho, Ulisses; Wambier, Leticia Stadler; Zedebski, Rosaio De Arruda Moura; De Moraes, Mari Eli Leonelli; De Moraes, Luiz Cesar

    2016-01-01

    This study employed a posteriori registration and subtraction of radiographic images to quantify the apical root resorption in maxillary permanent central incisors after orthodontic treatment, and assessed whether the external apical root resorption (EARR) was related to a range of parameters involved in the treatment. A sample of 79 patients (mean age, 13.5±2.2 years) with no history of trauma or endodontic treatment of the maxillary permanent central incisors was selected. Periapical radiographs taken before and after orthodontic treatment were digitized and imported to the Regeemy software. Based on an analysis of the posttreatment radiographs, the length of the incisors was measured using Image J software. The mean EARR was described in pixels and relative root resorption (%). The patient's age and gender, tooth extraction, use of elastics, and treatment duration were evaluated to identify possible correlations with EARR. The mean EARR observed was 15.44±12.1 pixels (5.1% resorption). No differences in the mean EARR were observed according to patient characteristics (gender, age) or treatment parameters (use of elastics, treatment duration). The only parameter that influenced the mean EARR of a patient was the need for tooth extraction. A posteriori registration and subtraction of periapical radiographs was a suitable method to quantify EARR after orthodontic treatment, and the need for tooth extraction increased the extent of root resorption after orthodontic treatment

  1. Evaluation of interpolation effects on upsampling and accuracy of cost functions-based optimized automatic image registration.

    Science.gov (United States)

    Mahmoudzadeh, Amir Pasha; Kashou, Nasser H

    2013-01-01

    Interpolation has become a default operation in image processing and medical imaging and is one of the important factors in the success of an intensity-based registration method. Interpolation is needed if the fractional unit of motion is not matched and located on the high resolution (HR) grid. The purpose of this work is to present a systematic evaluation of eight standard interpolation techniques (trilinear, nearest neighbor, cubic Lagrangian, quintic Lagrangian, hepatic Lagrangian, windowed Sinc, B-spline 3rd order, and B-spline 4th order) and to compare the effect of cost functions (least squares (LS), normalized mutual information (NMI), normalized cross correlation (NCC), and correlation ratio (CR)) for optimized automatic image registration (OAIR) on 3D spoiled gradient recalled (SPGR) magnetic resonance images (MRI) of the brain acquired using a 3T GE MR scanner. Subsampling was performed in the axial, sagittal, and coronal directions to emulate three low resolution datasets. Afterwards, the low resolution datasets were upsampled using different interpolation methods, and they were then compared to the high resolution data. The mean squared error, peak signal to noise, joint entropy, and cost functions were computed for quantitative assessment of the method. Magnetic resonance image scans and joint histogram were used for qualitative assessment of the method.

  2. Evaluation of Interpolation Effects on Upsampling and Accuracy of Cost Functions-Based Optimized Automatic Image Registration

    Directory of Open Access Journals (Sweden)

    Amir Pasha Mahmoudzadeh

    2013-01-01

    Full Text Available Interpolation has become a default operation in image processing and medical imaging and is one of the important factors in the success of an intensity-based registration method. Interpolation is needed if the fractional unit of motion is not matched and located on the high resolution (HR grid. The purpose of this work is to present a systematic evaluation of eight standard interpolation techniques (trilinear, nearest neighbor, cubic Lagrangian, quintic Lagrangian, hepatic Lagrangian, windowed Sinc, B-spline 3rd order, and B-spline 4th order and to compare the effect of cost functions (least squares (LS, normalized mutual information (NMI, normalized cross correlation (NCC, and correlation ratio (CR for optimized automatic image registration (OAIR on 3D spoiled gradient recalled (SPGR magnetic resonance images (MRI of the brain acquired using a 3T GE MR scanner. Subsampling was performed in the axial, sagittal, and coronal directions to emulate three low resolution datasets. Afterwards, the low resolution datasets were upsampled using different interpolation methods, and they were then compared to the high resolution data. The mean squared error, peak signal to noise, joint entropy, and cost functions were computed for quantitative assessment of the method. Magnetic resonance image scans and joint histogram were used for qualitative assessment of the method.

  3. Evaluation of the performance of deformable image registration between planning CT and CBCT images for the pelvic region: comparison between hybrid and intensity-based DIR.

    Science.gov (United States)

    Takayama, Yoshiki; Kadoya, Noriyuki; Yamamoto, Takaya; Ito, Kengo; Chiba, Mizuki; Fujiwara, Kousei; Miyasaka, Yuya; Dobashi, Suguru; Sato, Kiyokazu; Takeda, Ken; Jingu, Keiichi

    2017-07-01

    This study aimed to evaluate the performance of the hybrid deformable image registration (DIR) method in comparison with intensity-based DIR for pelvic cone-beam computed tomography (CBCT) images, using intensity and anatomical information. Ten prostate cancer patients treated with intensity-modulated radiation therapy (IMRT) were studied. Nine or ten CBCT scans were performed for each patient. First, rigid registration was performed between the planning CT and all CBCT images using gold fiducial markers, and then DIR was performed. The Dice similarity coefficient (DSC) and center of mass (COM) displacement were used to evaluate the quantitative DIR accuracy. The average DSCs for intensity-based DIR for the prostate, rectum, bladder, and seminal vesicles were 0.84 ± 0.05, 0.75 ± 0.05, 0.69 ± 0.07 and 0.65 ± 0.11, respectively, whereas those values for hybrid DIR were 0.98 ± 0.00, 0.97 ± 0.01, 0.98 ± 0.00 and 0.94 ± 0.03, respectively (P DSC for hybrid DIR had a higher DSC value and smaller COM displacement for all structures and all patients, compared with intensity-based DIR. Thus, the accumulative dose based on hybrid DIR might be trusted as a high-precision dose estimation method that takes into account organ movement during treatment radiotherapy. © The Author 2017. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.

  4. Supplementary Material for: Growth curve registration for evaluating salinity tolerance in barley

    KAUST Repository

    Meng, Rui

    2017-01-01

    Abstract Background Smarthouses capable of non-destructive, high-throughput plant phenotyping collect large amounts of data that can be used to understand plant growth and productivity in extreme environments. The challenge is to apply the statistical tool that best analyzes the data to study plant traits, such as salinity tolerance, or plant-growth-related traits. Results We derive family-wise salinity sensitivity (FSS) growth curves and use registration techniques to summarize growth patterns of HEB-25 barley families and the commercial variety, Navigator. We account for the spatial variation in smarthouse microclimates and in temporal variation across phenotyping runs using a functional ANOVA model to derive corrected FSS curves. From FSS, we derive corrected values for family-wise salinity tolerance, which are strongly negatively correlated with Na but not significantly with K, indicating that Na content is an important factor affecting salinity tolerance in these families, at least for plants of this age and grown in these conditions. Conclusions Our family-wise methodology is suitable for analyzing the growth curves of a large number of plants from multiple families. The corrected curves accurately account for the spatial and temporal variations among plants that are inherent to high-throughput experiments.

  5. Interactive initialization of 2D/3D rigid registration

    International Nuclear Information System (INIS)

    Gong, Ren Hui; Güler, Özgür; Kürklüoglu, Mustafa; Lovejoy, John; Yaniv, Ziv

    2013-01-01

    Purpose: Registration is one of the key technical components in an image-guided navigation system. A large number of 2D/3D registration algorithms have been previously proposed, but have not been able to transition into clinical practice. The authors identify the primary reason for the lack of adoption with the prerequisite for a sufficiently accurate initial transformation, mean target registration error of about 10 mm or less. In this paper, the authors present two interactive initialization approaches that provide the desired accuracy for x-ray/MR and x-ray/CT registration in the operating room setting. Methods: The authors have developed two interactive registration methods based on visual alignment of a preoperative image, MR, or CT to intraoperative x-rays. In the first approach, the operator uses a gesture based interface to align a volume rendering of the preoperative image to multiple x-rays. The second approach uses a tracked tool available as part of a navigation system. Preoperatively, a virtual replica of the tool is positioned next to the anatomical structures visible in the volumetric data. Intraoperatively, the physical tool is positioned in a similar manner and subsequently used to align a volume rendering to the x-ray images using an augmented reality (AR) approach. Both methods were assessed using three publicly available reference data sets for 2D/3D registration evaluation. Results: In the authors' experiments, the authors show that for x-ray/MR registration, the gesture based method resulted in a mean target registration error (mTRE) of 9.3 ± 5.0 mm with an average interaction time of 146.3 ± 73.0 s, and the AR-based method had mTREs of 7.2 ± 3.2 mm with interaction times of 44 ± 32 s. For x-ray/CT registration, the gesture based method resulted in a mTRE of 7.4 ± 5.0 mm with an average interaction time of 132.1 ± 66.4 s, and the AR-based method had mTREs of 8.3 ± 5.0 mm with interaction times of 58 ± 52 s. Conclusions: Based on the

  6. Interactive initialization of 2D/3D rigid registration

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Ren Hui; Güler, Özgür [The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children' s National Medical Center, Washington, DC 20010 (United States); Kürklüoglu, Mustafa [Department of Cardiac Surgery, Children' s National Medical Center, Washington, DC 20010 (United States); Lovejoy, John [Department of Orthopaedic Surgery and Sports Medicine, Children' s National Medical Center, Washington, DC 20010 (United States); Yaniv, Ziv, E-mail: ZYaniv@childrensnational.org [The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children' s National Medical Center, Washington, DC 20010 and Departments of Pediatrics and Radiology, George Washington University, Washington, DC 20037 (United States)

    2013-12-15

    Purpose: Registration is one of the key technical components in an image-guided navigation system. A large number of 2D/3D registration algorithms have been previously proposed, but have not been able to transition into clinical practice. The authors identify the primary reason for the lack of adoption with the prerequisite for a sufficiently accurate initial transformation, mean target registration error of about 10 mm or less. In this paper, the authors present two interactive initialization approaches that provide the desired accuracy for x-ray/MR and x-ray/CT registration in the operating room setting. Methods: The authors have developed two interactive registration methods based on visual alignment of a preoperative image, MR, or CT to intraoperative x-rays. In the first approach, the operator uses a gesture based interface to align a volume rendering of the preoperative image to multiple x-rays. The second approach uses a tracked tool available as part of a navigation system. Preoperatively, a virtual replica of the tool is positioned next to the anatomical structures visible in the volumetric data. Intraoperatively, the physical tool is positioned in a similar manner and subsequently used to align a volume rendering to the x-ray images using an augmented reality (AR) approach. Both methods were assessed using three publicly available reference data sets for 2D/3D registration evaluation. Results: In the authors' experiments, the authors show that for x-ray/MR registration, the gesture based method resulted in a mean target registration error (mTRE) of 9.3 ± 5.0 mm with an average interaction time of 146.3 ± 73.0 s, and the AR-based method had mTREs of 7.2 ± 3.2 mm with interaction times of 44 ± 32 s. For x-ray/CT registration, the gesture based method resulted in a mTRE of 7.4 ± 5.0 mm with an average interaction time of 132.1 ± 66.4 s, and the AR-based method had mTREs of 8.3 ± 5.0 mm with interaction times of 58 ± 52 s. Conclusions: Based on

  7. MO-G-18C-03: Evaluation of Deformable Image Registration for Lung Motion Estimation Using Hyperpolarized Gas Tagging MRI

    International Nuclear Information System (INIS)

    Huang, Q; Zhang, Y; Liu, Y; Hu, L; Yin, F; Cai, J; Miller, W

    2014-01-01

    Purpose: Hyperpolarized gas (HP) tagging MRI is a novel imaging technique for direct measurement of lung motion during breathing. This study aims to quantitatively evaluate the accuracy of deformable image registration (DIR) in lung motion estimation using HP tagging MRI as references. Methods: Three healthy subjects were imaged using the HP MR tagging, as well as a high-resolution 3D proton MR sequence (TrueFISP) at the end-of-inhalation (EOI) and the end-of-exhalation (EOE). Ground truth of lung motion and corresponding displacement vector field (tDVF) was derived from HP tagging MRI by manually tracking the displacement of tagging grids between EOI and EOE. Seven different DIR methods were applied to the high-resolution TrueFISP MR images (EOI and EOE) to generate the DIR-based DVFs (dDVF). The DIR methods include Velocity (VEL), MIM, Mirada, multi-grid B-spline from Elastix (MGB) and 3 other algorithms from DIRART toolbox (Double Force Demons (DFD), Improved Lucas-Kanade (ILK), and Iterative Optical Flow (IOF)). All registrations were performed by independent experts. Target registration error (TRE) was calculated as tDVF – dDVF. Analysis was performed for the entire lungs, and separately for the upper and lower lungs. Results: Significant differences between tDVF and dDVF were observed. Besides the DFD and IOF algorithms, all other dDVFs showed similarity in deformation magnitude distribution but away from the ground truth. The average TRE for entire lung ranged 2.5−23.7mm (mean=8.8mm), depending on the DIR method and subject's breathing amplitude. Larger TRE (13.3–23.7mm) was found in subject with larger breathing amplitude of 45.6mm. TRE was greater in lower lung (2.5−33.9 mm, mean=12.4mm) than that in upper lung (2.5−11.9 mm, mean=5.8mm). Conclusion: Significant differences were observed in lung motion estimation between the HP gas tagging MRI method and the DIR methods, especially when lung motion is large. Large variation among different

  8. MO-G-18C-03: Evaluation of Deformable Image Registration for Lung Motion Estimation Using Hyperpolarized Gas Tagging MRI

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Q; Zhang, Y [Duke University, Durham, NC (United States); Liu, Y [Duke University (United States); Hu, L; Yin, F; Cai, J [Duke University Medical Center, Durham, NC (United States); Miller, W [University of Virginia, Charlottesville, VA (United States)

    2014-06-15

    Purpose: Hyperpolarized gas (HP) tagging MRI is a novel imaging technique for direct measurement of lung motion during breathing. This study aims to quantitatively evaluate the accuracy of deformable image registration (DIR) in lung motion estimation using HP tagging MRI as references. Methods: Three healthy subjects were imaged using the HP MR tagging, as well as a high-resolution 3D proton MR sequence (TrueFISP) at the end-of-inhalation (EOI) and the end-of-exhalation (EOE). Ground truth of lung motion and corresponding displacement vector field (tDVF) was derived from HP tagging MRI by manually tracking the displacement of tagging grids between EOI and EOE. Seven different DIR methods were applied to the high-resolution TrueFISP MR images (EOI and EOE) to generate the DIR-based DVFs (dDVF). The DIR methods include Velocity (VEL), MIM, Mirada, multi-grid B-spline from Elastix (MGB) and 3 other algorithms from DIRART toolbox (Double Force Demons (DFD), Improved Lucas-Kanade (ILK), and Iterative Optical Flow (IOF)). All registrations were performed by independent experts. Target registration error (TRE) was calculated as tDVF – dDVF. Analysis was performed for the entire lungs, and separately for the upper and lower lungs. Results: Significant differences between tDVF and dDVF were observed. Besides the DFD and IOF algorithms, all other dDVFs showed similarity in deformation magnitude distribution but away from the ground truth. The average TRE for entire lung ranged 2.5−23.7mm (mean=8.8mm), depending on the DIR method and subject's breathing amplitude. Larger TRE (13.3–23.7mm) was found in subject with larger breathing amplitude of 45.6mm. TRE was greater in lower lung (2.5−33.9 mm, mean=12.4mm) than that in upper lung (2.5−11.9 mm, mean=5.8mm). Conclusion: Significant differences were observed in lung motion estimation between the HP gas tagging MRI method and the DIR methods, especially when lung motion is large. Large variation among different

  9. SU-F-J-84: Comparison of Quantitative Deformable Image Registration Evaluation Tools: Application to Prostate IGART

    Energy Technology Data Exchange (ETDEWEB)

    Dogan, N [University of Miami, Miami, FL (United States); Weiss, E [Virginia Commonwealth University, Richmond, Virginia (United States); Sleeman, W; Williamson, J [Virginia Commonwealth University, Richmond, VA (United States); Christensen, G [University of Iowa, Iowa City, IA (United States); Ford, J [University of Miami Miller School of Medicine, Miami, FL (United States)

    2016-06-15

    Purpose: Errors in displacement vector fields (DVFs) generated by Deformable Image Registration (DIR) algorithms can give rise to significant uncertainties in contour propagation and dose accumulation in Image-Guided Adaptive Radiotherapy (IGART). The purpose of this work is to assess the accuracy of two DIR algorithms using a variety of quality metrics for prostate IGART. Methods: Pelvic CT images were selected from an anonymized database of nineteen prostate patients who underwent 8–12 serial scans during radiotherapy. Prostate, bladder, and rectum were contoured on 34 image-sets for three patients by the same physician. The planning CT was deformably-registered to daily CT using three variants of the Small deformation Inverse Consistent Linear Elastic (SICLE) algorithm: Grayscale-driven (G), Contour-driven (C, which utilizes segmented structures to drive DIR), combined (G+C); and also grayscale ITK demons (Gd). The accuracy of G, C, G+C SICLE and Gd registrations were evaluated using a new metric Edge Gradient Distance to Agreement (EGDTA) and other commonly-used metrics such as Pearson Correlation Coefficient (PCC), Dice Similarity Index (DSI) and Hausdorff Distance (HD). Results: C and G+C demonstrated much better performance at organ boundaries, revealing the lowest HD and highest DSI, in prostate, bladder and rectum. G+C demonstrated the lowest mean EGDTA (1.14 mm), which corresponds to highest registration quality, compared to G and C DVFs (1.16 and 2.34 mm). However, demons DIR showed the best overall performance, revealing lowest EGDTA (0.73 mm) and highest PCC (0.85). Conclusion: As expected, both C- and C+G SICLE more accurately reproduce manually-contoured target datasets than G-SICLE or Gd using HD and DSI metrics. In general, the Gd appears to have difficulty reproducing large daily position and shape changes in the rectum and bladder. However, Gd outperforms SICLE in terms of EGDTA and PCC metrics, possibly at the expense of topological quality of

  10. The use of Landsat-4 MSS digital data in temporal data sets and the evaluation of scene-to-scene registration accuracy

    Science.gov (United States)

    Anderson, J. E.

    1985-01-01

    The MSS sensor on Landsat 4 is, in certain performance aspects, diferent from those of Landsats 1 through 3. These differences created some concern in the NASA research community as to whether individual data sets can be registered accurately enough to produce acceptable data sets for multitemporal data analysis. The use of Landsat 4 MSS digital data in temporal data sets is examined and a method is presented for estimating temporal registration accuracy based on the use of an X-Y digitizer and grey tone electrostatic plots. Results indicate that the RMS temporal registration errors are not significantly different from the temporal data sets generated using Landsat 4 and Landsat 2 data (33.35 meters) and the temporal data set constructed from two Landsat 2 data sets (33.61 meters). A derivation of the model used to evaluate the temporal registration is included.

  11. SU-C-17A-03: Evaluation of Deformable Image Registration Methods Between MRI and CT for Prostate Cancer Radiotherapy

    International Nuclear Information System (INIS)

    Wen, N; Glide-Hurst, C; Zhong, H; Chin, K; Kumarasiri, A; Liu, C; Liu, M; Siddiqui, S

    2014-01-01

    Purpose: We evaluated the performance of two commercially available and one open source B-Spline deformable image registration (DIR) algorithms between T2-weighted MRI and treatment planning CT using the DICE indices. Methods: CT simulation (CT-SIM) and MR simulation (MR-SIM) for four prostate cancer patients were conducted on the same day using the same setup and immobilization devices. CT images (120 kVp, 500 mAs, voxel size = 1.1x1.1x3.0 mm3) were acquired using an open-bore CT scanner. T2-weighted Turbo Spine Echo (T2W-TSE) images (TE/TR/α = 80/4560 ms/90°, voxel size = 0.7×0.7×2.5 mm3) were scanned on a 1.0T high field open MR-SIM. Prostates, seminal vesicles, rectum and bladders were delineated on both T2W-TSE and CT images by the attending physician. T2W-TSE images were registered to CT images using three DIR algorithms, SmartAdapt (Varian), Velocity AI (Velocity) and Elastix (Klein et al 2010) and contours were propagated. DIR results were evaluated quantitatively or qualitatively by image comparison and calculating organ DICE indices. Results: Significant differences in the contours of prostate and seminal vesicles were observed between MR and CT. On average, volume changes of the propagated contours were 5%, 2%, 160% and 8% for the prostate, seminal vesicles, bladder and rectum respectively. Corresponding mean DICE indices were 0.7, 0.5, 0.8, and 0.7. The intraclass correlation coefficient (ICC) was 0.9 among three algorithms for the Dice indices. Conclusion: Three DIR algorithms for CT/MR registration yielded similar results for organ propagation. Due to the different soft tissue contrasts between MRI and CT, organ delineation of prostate and SVs varied significantly, thus efforts to develop other DIR evaluation metrics are warranted. Conflict of interest: Submitting institution has research agreements with Varian Medical System and Philips Healthcare

  12. SU-C-17A-03: Evaluation of Deformable Image Registration Methods Between MRI and CT for Prostate Cancer Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Wen, N; Glide-Hurst, C; Zhong, H; Chin, K; Kumarasiri, A; Liu, C; Liu, M; Siddiqui, S [I Chetty, Henry Ford Health System, Detroit, MI (United States)

    2014-06-15

    Purpose: We evaluated the performance of two commercially available and one open source B-Spline deformable image registration (DIR) algorithms between T2-weighted MRI and treatment planning CT using the DICE indices. Methods: CT simulation (CT-SIM) and MR simulation (MR-SIM) for four prostate cancer patients were conducted on the same day using the same setup and immobilization devices. CT images (120 kVp, 500 mAs, voxel size = 1.1x1.1x3.0 mm3) were acquired using an open-bore CT scanner. T2-weighted Turbo Spine Echo (T2W-TSE) images (TE/TR/α = 80/4560 ms/90°, voxel size = 0.7×0.7×2.5 mm3) were scanned on a 1.0T high field open MR-SIM. Prostates, seminal vesicles, rectum and bladders were delineated on both T2W-TSE and CT images by the attending physician. T2W-TSE images were registered to CT images using three DIR algorithms, SmartAdapt (Varian), Velocity AI (Velocity) and Elastix (Klein et al 2010) and contours were propagated. DIR results were evaluated quantitatively or qualitatively by image comparison and calculating organ DICE indices. Results: Significant differences in the contours of prostate and seminal vesicles were observed between MR and CT. On average, volume changes of the propagated contours were 5%, 2%, 160% and 8% for the prostate, seminal vesicles, bladder and rectum respectively. Corresponding mean DICE indices were 0.7, 0.5, 0.8, and 0.7. The intraclass correlation coefficient (ICC) was 0.9 among three algorithms for the Dice indices. Conclusion: Three DIR algorithms for CT/MR registration yielded similar results for organ propagation. Due to the different soft tissue contrasts between MRI and CT, organ delineation of prostate and SVs varied significantly, thus efforts to develop other DIR evaluation metrics are warranted. Conflict of interest: Submitting institution has research agreements with Varian Medical System and Philips Healthcare.

  13. PATENT EVALUATION FOR ACCOUNTING REGISTRATION – STRATEGIC TOOL FOR BUSINESS DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Riana Iren RADU

    2014-06-01

    Full Text Available Following the evaluation proces, it is possible that some intangible assets, recorded in the economic entity’ s accounting, have a higher value than accounting value. An example is the patent obtained by an economic entity, revealed at the overall cost of research and development, as well as the patent fees, but in view of the economic benefits, generated by its use in the production, has a higher fair value. The purpose of this paper is to show the good impact on the economic side of the entity which generates the productive patent, as representative of intellectual property, following the evaluation, resulting a value which leads to increase the overall economic entity. The evaluation of a productive patent aims to increase the market value of the economic entity on one hand, but on the other hand, looking ahead, the first order effect of this action is related to increasing opportunities for funding its activity.

  14. Oral cavity evaluation and dental chart registration of coati (Nasua nasua) in captivity

    OpenAIRE

    Freitas, Elisângela P; Rahal, Sheila Canevese; Teixeira, Carlos Roberto; Teixeira, Rodrigo Hidalgo Friciello; Mendes, Guilherme Martines Teixeira; Gioso, Marco Antonio

    2008-01-01

    The aims of this study were to develop a dental chart, evaluate any oral cavity disease, develop gypsum models of the dental arches, and to register the occlusions found in coatis (Nasua nasua) in captivity. Formulation of the dental chart was assisted by intraoral radiographs from the head of an adult coati cadaver of the same species with the following dental formula: I 3/3, C 1/1, P 4/3, M 2/2. Seven live coatis of the Nasua nasua species were evaluated. Five of the seven coatis presented ...

  15. Evaluating the Impact of Social Media Marketing on Online Course Registration

    Science.gov (United States)

    Spackman, Jonathan S.; Larsen, Ross

    2017-01-01

    This article validated one possible method, found in the luxury fashion industry, for evaluating the effectiveness of Facebook marketing activities on increasing enrollments in continuing higher education online courses. A survey assessing the qualities of social media marketing, value equity, relationship equity, brand equity, and purchase…

  16. Evaluation of the mutual information cost function for registration of SPET and MRI images of the brain

    International Nuclear Information System (INIS)

    Taleb, M.; McKay, E.

    1999-01-01

    Full text: Any strategy for image registration requires some method (a cost function) by which two images may be compared The mutual information (MI) between images is one such cost function. MI measures the structural similarity between pairs of gray-scale images and performs cross-modality image registration with minimal image pre-processing. This project compares the performance of MI vs the sum of absolute differences (SAD) 'gold standard' in monomodality image registration problems. It also examines the precision of cross-modality registration based on MI, using a human observer to decide whether registration is accurate. Thirteen paired brain SPET scans were registered using SAD as a cost function. Registration was repeated using MI and differences from the SAD results were recorded. Ten paired MRI and SPET brain scans registered using the MI cost function. Registration was repeated three times for each pair, varying the SPET position or orientation each time. Comparing MI to SAD, the median values of translation error were 2.85, 4.63 and 2.56 mm in the x, y and z axis and 0.5 j , 1.1 j and 1.0 j around the x, y and z axis respectively. For the cross-modality problems, the mean standard deviation (MSD) observed in x, y and z positioning was 0.18, 0.28 and 0.16 mm respectively. The MSD of orientation was 5.35 j , 1.95 j and 2.48 j around the x, y and z axis respectively. MI performed as well as SAD for monomodality registration. Unlike SAD, MI is also useful for cross-modality image registration tasks, producing visually acceptable results with minimal preprocessing

  17. Oral cavity evaluation and dental chart registration of coati (Nasua nasua) in captivity.

    Science.gov (United States)

    Freitas, Elisângela P; Rahal, Sheila C; Teixeira, Carlos R; Teixeira, Rodrigo H F; Mendes, Guilherme M; Gioso, Marco A

    2008-06-01

    The aims of this study were to develop a dental evaluate any oral cavity disease, develop gypsum models of the dental arches, and to register the occlusions found in coatis (Nasua nasua) in captivity Formulation of the dental chart was assisted by intraoral radiographs from the head of an adult coati cadaver of the same species with the following dental formula.: I 3/3, C 1/1, P 4/3, M 2/2. Seven live coatis of the Nasua nasua species were evaluated. Five of the seven coatis presented with various dental abnormalities as follows: dental plaque (71.4 0%), gingivitis (71.4 %), periodontitis (57.1 %), dental stain (42.9 %), dental abrasion (57.1 %), dental fracture (57.1 %), pulp exposure (42.9 %), malocclusion (57.1 %) and supernumerary teeth (14.2 %).

  18. Dosimetric- and geometric evaluation of adaptive H&N IMRT using deformable image registration

    DEFF Research Database (Denmark)

    Eiland, R. B.; Behrens, C. F.; Sjöström, D.

    2012-01-01

    CT and the dose recalculated. DVH points (D50 for parotid glands and Dmax for spinal cord) were evaluated. Conformity index (CI), lesion coverage fraction (LCF) and normal tissue overdose fraction (NTOF) was evaluated with regard to target coverage. Results: The PTV volume was estimated larger for dCT than Re......CT was 11.2% (range  28.0; 16.7), 26.2% (range 42.1; 3.4) and 10.9% (range 33.3; 32.3) for parotid dxt, parotid sin and spinal cord, respectively. The median CMS was 0.51 cm (range 0.19; 2.22). DSC had a median of 0.47 (range 0.45; 0.85). The median relative deviation from ReCT in DVH points...... for parotid dxt, parotid sin and spinal cord was 8.3% (range 8.4; 25.3), 12.7% (range 28.6; 31.0), and 1.3% (range 5.4; 31.8), respectively. CI, LCF and NTOF are visualized in the figure. Ideal values of CI and LCF are unity and zero for NTOF. Conclusions: The DIR produced geometrical results similar...

  19. Evaluation of the tumor registration error in biopsy procedures performed under real-time PET/CT guidance.

    Science.gov (United States)

    Fanchon, Louise M; Apte, Adytia; Schmidtlein, C Ross; Yorke, Ellen; Hu, Yu-Chi; Dogan, Snjezana; Hatt, Mathieu; Visvikis, Dimitris; Humm, John L; Solomon, Stephen B; Kirov, Assen S

    2017-10-01

    The purpose of this study is to quantify tumor displacement during real-time PET/CT guided biopsy and to investigate correlations between tumor displacement and false-negative results. 19 patients who underwent real-time 18 F-FDG PET-guided biopsy and were found positive for malignancy were included in this study under IRB approval. PET/CT images were acquired for all patients within minutes prior to biopsy to visualize the FDG-avid region and plan the needle insertion. The biopsy needle was inserted and a post-insertion CT scan was acquired. The two CT scans acquired before and after needle insertion were registered using a deformable image registration (DIR) algorithm. The DIR deformation vector field (DVF) was used to calculate the mean displacement between the pre-insertion and post-insertion CT scans for a region around the tip of the biopsy needle. For 12 patients one biopsy core from each was tracked during histopathological testing to investigate correlations of the mean displacement between the two CT scans and false-negative or true-positive biopsy results. For 11 patients, two PET scans were acquired; one at the beginning of the procedure, pre-needle insertion, and an additional one with the needle in place. The pre-insertion PET scan was corrected for intraprocedural motion by applying the DVF. The corrected PET was compared with the post-needle insertion PET to validate the correction method. The mean displacement of tissue around the needle between the pre-biopsy CT and the postneedle insertion CT was 5.1 mm (min = 1.1 mm, max = 10.9 mm and SD = 3.0 mm). For mean displacements larger than 7.2 mm, the biopsy cores gave false-negative results. Correcting pre-biopsy PET using the DVF improved the PET/CT registration in 8 of 11 cases. The DVF obtained from DIR of the CT scans can be used for evaluation and correction of the error in needle placement with respect to the FDG-avid area. Misregistration between the pre-biopsy PET and the CT acquired with the

  20. Registration, psychiatric evaluation and adherence to psychiatric treatment after suicide attempt

    DEFF Research Database (Denmark)

    Nordentoft, Merete; Søgaard, Mette

    2005-01-01

    Persons who are treated at hospital after attempted suicide comprise a high-risk group for suicide. The proposal for a National Programme for Prevention of Suicide and Suicide Attempt in Denmark recommends that all persons who attempt suicide should be offered treatment and that treatment should....... Only few patients were not referred to any treatment at all, but among the patients referred to psychiatric treatment, only those admitted involuntarily received treatment in 100% of the planned cases. For outpatient treatment in the suicide prevention clinic, the percentage that attended planned...... be implemented, using a supportive and guiding principle. The aim of the present study is to investigate whether patients receive psychiatric evaluation after a suicide attempt, and whether they receive the psychiatric treatment to which they are referred. In the Copenhagen Hospital Corporation in four emergency...

  1. Clinical leadership and pre-registration nursing programmes: A model for clinical leadership and a prospective curriculum implementation and evaluation research strategy.

    Science.gov (United States)

    Brown, Angela; Dewing, Jan; Crookes, Patrick

    2016-07-01

    To present for wider debate a conceptual model for clinical leadership development in pre-registration nursing programmes and a proposed implementation plan. Globally, leadership in nursing has become a significant issue. Whilst there is continued support for leadership preparation in pre-registration nursing programmes, there have been very few published accounts of curriculum content and/or pedagogical approaches that foster clinical leadership development in pre-registration nursing. A doctoral research study has resulted in the creation of an overarching model for clinical leadership. A multi-method research study using theoretical and empirical literature 1974-2015, a focus group, expert opinion and a national on-line survey. A conceptual model of clinical leadership development in pre-registration nursing programme is presented, including the infinity loop of clinical leadership, an integral curriculum thread and a conceptual model: a curriculum-pedagogy nexus for clinical leadership. In order to test out usability and evaluate effectiveness, a multi method programme of research in one school of nursing in Australia is outlined. Implementation of the proposed conceptual model for clinical leadership development in pre-registration nursing programmes and a programme of (post-doctoral) research will contribute to what is known about curriculum content and pedagogy for nurse academics. Importantly, for nursing students and the profession as a whole, there is a clearer expectation of what clinical leadership might look like in the novice registered nurse. For nurse academics a model is offered for consideration in curriculum design and implementation with an evaluation strategy that could be replicated. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. [Evaluation of a registration card for logging electrocardiographic records into standard personal computers].

    Science.gov (United States)

    Pizzuti, A; Baralis, G; Bassignana, A; Antonielli, E; Di Leo, M

    1997-01-01

    The MS200 Cardioscope, from MRT Micro as., Norway, is a 12 channel ECG card to be directly inserted into a standard personal computer (PC). The standard ISA Bus compatible half length card comes with a set of 10 cables with electrodes and the software for recording, displaying and saving ECG signals. The system is supplied with DOS or Windows software. The goal of the present work was to evaluate the affordability and usability of the MS200 in a clinical setting. We tested the 1.5 DOS version of the software. In 30 patients with various cardiac diseases the ECG signal has been recorded with MS200 and with standard Hellige CardioSmart equipment. The saved ECGs were recalled and printed using an Epson Stylus 800 ink-jet printer. Two cardiologists reviewed the recordings for a looking at output quality, amplitude and speed precision, artifacts, etc. 1) Installation: the card has proven to be totally compatible with the hardware; no changes in default settings had to be made. 2) Usage: the screens are clear; the commands and menus are intuitive and easy to use. Due to the boot-strap and software loading procedures and, most important, off-line printing, the time needed to obtain a complete ECG printout has been longer than that of the reference machine. 3) Archiving and retrieval of ECG: the ECG curves can be saved in original or compressed form: selecting the latter, the noise and non-ECG information is filtered away and the space consumption on disk is reduced: on average, 20 Kb are needed for 10 seconds of signal. The MS200 can be run on a Local Area Network and is prepared for integrating with an existing informative system: we are currently testing the system in this scenery. 4) MS200 includes options for on-line diagnosis, a technology we have not tested in the present work. 5) The only setting allowed for printing full pages is letter size (A4): the quality of printouts is good, with a resolution of 180 DPI. In conclusion, the MS200 system seems reliable and

  3. Usefulness of the classification technique of cerebral artery for 2D/3D registration

    International Nuclear Information System (INIS)

    Takemura, Akihiro; Suzuki, Masayuki; Kikuchi, Yuzo; Okumura, Yusuke; Harauchi, Hajime

    2007-01-01

    Several papers have proposed 2D/3D registration methods of the cerebral artery using magnetic resonance angiography (MRA) and digital subtraction angiography (DSA). Since differences between vessels in a DSA image and MRA volume data cause registration failure, we previously proposed a method to extract vessels from MRA volume data using a technique based on classification of the cerebral artery. In this paper, we evaluated the usefulness of this classification technique by evaluating the reliability of this 2D/3D registration method. This classification method divides the cerebral artery in MRA volume data into 12 segments. According to the results of the classification, structures corresponding to vessels on a DSA image can then be extracted. We applied the 2D/3D registration with/without classification to 16 pairs of MRA volume data and DSA images obtained from six patients. The registration results were scored into four levels (Excellent, Good, Fair and Poor). The rates of successful registration (>fair) were 37.5% for registration without classification and 81.3% for that with classification. These findings suggested that there was a low percentage of incorrectly extracted voxels and we could facilitate reliable registration. Thus, the classification technique was shown to be useful for feature-based 2D/3D registration. (author)

  4. Performance Evaluation of State-of-the-Art Local Feature Detectors and Descriptors in the Context of Longitudinal Registration of Retinal Images.

    Science.gov (United States)

    Saha, Sajib K; Xiao, Di; Frost, Shaun; Kanagasingam, Yogesan

    2018-02-17

    In this paper we systematically evaluate the performance of several state-of-the-art local feature detectors and descriptors in the context of longitudinal registration of retinal images. Longitudinal (temporal) registration facilitates to track the changes in the retina that has happened over time. A wide number of local feature detectors and descriptors exist and many of them have already applied for retinal image registration, however, no comparative evaluation has been made so far to analyse their respective performance. In this manuscript we evaluate the performance of the widely known and commonly used detectors such as Harris, SIFT, SURF, BRISK, and bifurcation and cross-over points. As of descriptors SIFT, SURF, ALOHA, BRIEF, BRISK and PIIFD are used. Longitudinal retinal image datasets containing a total of 244 images are used for the experiment. The evaluation reveals some potential findings including more robustness of SURF and SIFT keypoints than the commonly used bifurcation and cross-over points, when detected on the vessels. SIFT keypoints can be detected with a reliability of 59% for without pathology images and 45% for with pathology images. For SURF keypoints these values are respectively 58% and 47%. ALOHA descriptor is best suited to describe SURF keypoints, which ensures an overall matching accuracy, distinguishability of 83%, 93% and 78%, 83% for without pathology and with pathology images respectively.

  5. SU-F-J-81: Evaluation of Automated Deformable Registration Between Planning Computed Tomography (CT) and Daily Cone Beam CT Images Over the Course of Prostate Cancer Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Matney, J; Hammers, J; Kaidar-Person, O; Wang, A; Chen, R; Das, S; Marks, L; Mavroidis, P [University North Carolina, Chapel Hill, NC (United States)

    2016-06-15

    Purpose: To compute daily dose delivered during radiotherapy, deformable registration needs to be relatively fast, automated, and accurate. The aim of this study was to evaluate the performance of commercial deformable registration software for deforming between two modalities: planning computed tomography (pCT) images acquired for treatment planning and cone beam (CB) CT images acquired prior to each fraction of prostate cancer radiotherapy. Methods: A workflow was designed using MIM Software™ that aligned and deformed pCT into daily CBCT images in two steps: (1) rigid shifts applied after daily CBCT imaging to align patient anatomy to the pCT and (2) normalized intensity-based deformable registration to account for interfractional anatomical variations. The physician-approved CTV and organ and risk (OAR) contours were deformed from the pCT to daily CBCT over the course of treatment. The same structures were delineated on each daily CBCT by a radiation oncologist. Dice similarity coefficient (DSC) mean and standard deviations were calculated to quantify the deformable registration quality for prostate, bladder, rectum and femoral heads. Results: To date, contour comparisons have been analyzed for 31 daily fractions of 2 of 10 of the cohort. Interim analysis shows that right and left femoral head contours demonstrate the highest agreement (DSC: 0.96±0.02) with physician contours. Additionally, deformed bladder (DSC: 0.81±0.09) and prostate (DSC: 0.80±0.07) have good agreement with physician-defined daily contours. Rectum contours have the highest variations (DSC: 0.66±0.10) between the deformed and physician-defined contours on daily CBCT imaging. Conclusion: For structures with relatively high contrast boundaries on CBCT, the MIM automated deformable registration provided accurate representations of the daily contours during treatment delivery. These findings will permit subsequent investigations to automate daily dose computation from CBCT. However

  6. A Comparative Evaluation of 3 Different Free-Form Deformable Image Registration and Contour Propagation Methods for Head and Neck MRI: The Case of Parotid Changes During Radiotherapy.

    Science.gov (United States)

    Broggi, Sara; Scalco, Elisa; Belli, Maria Luisa; Logghe, Gerlinde; Verellen, Dirk; Moriconi, Stefano; Chiara, Anna; Palmisano, Anna; Mellone, Renata; Fiorino, Claudio; Rizzo, Giovanna

    2017-06-01

    To validate and compare the deformable image registration and parotid contour propagation process for head and neck magnetic resonance imaging in patients treated with radiotherapy using 3 different approaches-the commercial MIM, the open-source Elastix software, and an optimized version of it. Twelve patients with head and neck cancer previously treated with radiotherapy were considered. Deformable image registration and parotid contour propagation were evaluated by considering the magnetic resonance images acquired before and after the end of the treatment. Deformable image registration, based on free-form deformation method, and contour propagation available on MIM were compared to Elastix. Two different contour propagation approaches were implemented for Elastix software, a conventional one (DIR_Trx) and an optimized homemade version, based on mesh deformation (DIR_Mesh). The accuracy of these 3 approaches was estimated by comparing propagated to manual contours in terms of average symmetric distance, maximum symmetric distance, Dice similarity coefficient, sensitivity, and inclusiveness. A good agreement was generally found between the manual contours and the propagated ones, without differences among the 3 methods; in few critical cases with complex deformations, DIR_Mesh proved to be more accurate, having the lowest values of average symmetric distance and maximum symmetric distance and the highest value of Dice similarity coefficient, although nonsignificant. The average propagation errors with respect to the reference contours are lower than the voxel diagonal (2 mm), and Dice similarity coefficient is around 0.8 for all 3 methods. The 3 free-form deformation approaches were not significantly different in terms of deformable image registration accuracy and can be safely adopted for the registration and parotid contour propagation during radiotherapy on magnetic resonance imaging. More optimized approaches (as DIR_Mesh) could be preferable for critical

  7. Clinical trial registration in oral health journals.

    Science.gov (United States)

    Smaïl-Faugeron, V; Fron-Chabouis, H; Durieux, P

    2015-03-01

    Prospective registration of randomized controlled trials (RCTs) represents the best solution to reporting bias. The extent to which oral health journals have endorsed and complied with RCT registration is unknown. We identified journals publishing RCTs in dentistry, oral surgery, and medicine in the Journal Citation Reports. We classified journals into 3 groups: journals requiring or recommending trial registration, journals referring indirectly to registration, and journals providing no reference to registration. For the 5 journals with the highest 2012 impact factors in each group, we assessed whether RCTs with results published in 2013 had been registered. Of 78 journals examined, 32 (41%) required or recommended trial registration, 19 (24%) referred indirectly to registration, and 27 (35%) provided no reference to registration. We identified 317 RCTs with results published in the 15 selected journals in 2013. Overall, 73 (23%) were registered in a trial registry. Among those, 91% were registered retrospectively and 32% did not report trial registration in the published article. The proportion of trials registered was not significantly associated with editorial policies: 29% with results in journals that required or recommended registration, 15% in those that referred indirectly to registration, and 21% in those providing no reference to registration (P = 0.05). Less than one-quarter of RCTs with results published in a sample of oral health journals were registered with a public registry. Improvements are needed with respect to how journals inform and require their authors to register their trials. © International & American Associations for Dental Research.

  8. Size variation and collapse of emphysema holes at inspiration and expiration CT scan: evaluation with modified length scale method and image co-registration

    Directory of Open Access Journals (Sweden)

    Oh SY

    2017-07-01

    Full Text Available Sang Young Oh,1,* Minho Lee,1,* Joon Beom Seo,1,* Namkug Kim,1,2,* Sang Min Lee,1 Jae Seung Lee,3 Yeon Mok Oh3 1Department of Radiology, 2Department of Convergence Medicine, 3Department of Pulmonology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A novel approach of size-based emphysema clustering has been developed, and the size variation and collapse of holes in emphysema clusters are evaluated at inspiratory and expiratory computed tomography (CT. Thirty patients were visually evaluated for the size-based emphysema clustering technique and a total of 72 patients were evaluated for analyzing collapse of the emphysema hole in this study. A new approach for the size differentiation of emphysema holes was developed using the length scale, Gaussian low-pass filtering, and iteration approach. Then, the volumetric CT results of the emphysema patients were analyzed using the new method, and deformable registration was carried out between inspiratory and expiratory CT. Blind visual evaluations of EI by two readers had significant correlations with the classification using the size-based emphysema clustering method (r-values of reader 1: 0.186, 0.890, 0.915, and 0.941; reader 2: 0.540, 0.667, 0.919, and 0.942. The results of collapse of emphysema holes using deformable registration were compared with the pulmonary function test (PFT parameters using the Pearson’s correlation test. The mean extents of low-attenuation area (LAA, E1 (<1.5 mm, E2 (<7 mm, E3 (<15 mm, and E4 (≥15 mm were 25.9%, 3.0%, 11.4%, 7.6%, and 3.9%, respectively, at the inspiratory CT, and 15.3%, 1.4%, 6.9%, 4.3%, and 2.6%, respectively at the expiratory CT. The extents of LAA, E2, E3, and E4 were found to be significantly correlated with the PFT ­parameters (r=−0.53, −0.43, −0.48, and −0.25, with forced expiratory volume in 1 second (FEV1; −0.81, −0.62, −0.75, and

  9. 49 CFR 40.297 - Does anyone have the authority to change a SAP's initial evaluation?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Does anyone have the authority to change a SAP's... the Return-to-Duty Process § 40.297 Does anyone have the authority to change a SAP's initial... managed-care provider, any service agent) may change in any way the SAP's evaluation or recommendations...

  10. Fair Treatment by Authorities Is Related to Children's and Adolescents' Evaluations of Interracial Exclusion

    Science.gov (United States)

    Crystal, David S.; Killen, Melanie; Ruck, Martin D.

    2010-01-01

    This study investigated U.S. ethnic majority and minority youth's perceptions of fair and unfair treatment by authorities and evaluations of three situations of interracial exclusion (N = 685). Findings revealed that older adolescents who reported fair treatment by authorities were more likely to perceive wrongfulness in interracial exclusion…

  11. The Usage of Authority in Management Process and Evaluation of Emerged Problems: A Critical Approach

    Directory of Open Access Journals (Sweden)

    Salih ARSLAN

    2018-01-01

    Full Text Available This study aims to discuss the role, effect and the problems of ‘authority’ in the management process from a critical perspective. Firstly, the concept of authority is evaluated as a term in social science, then the role and effect of authority in management process is emphasized. The concept of authority is discussed not only in terms of its practical issues in management discipline but also the psychological, political and philosophical aspects of the term are included in discussion. Therefore, it is underlined that the usage of authority causes not only managerial problems but also some humane issues. So, the study professes that a moral authority is required besides other types of authority in management process. In this context, the study aims to test the accordance between theory and practice by comparing the results of the survey, which is implemented on public officers about their perception of authority, with the theoretical discussions.

  12. Deformable image registration for image guided prostate radiotherapy

    International Nuclear Information System (INIS)

    Cassetta, Roberto; Riboldi, Marco; Baroni, Guido; Leandro, Kleber; Novaes, Paulo Eduardo; Goncalves, Vinicius; Sakuraba, Roberto; Fattori, Giovanni

    2016-01-01

    In this study, we present a CT to CBCT deformable registration method based on the ITK library. An algorithm was developed in order to explore the soft tissue information of the CT-CBCT images to perform deformable image registration (DIR), making efforts to overcome the poor signal-to-noise ratio and HU calibration issues that limits CBCT use for treatment planning purposes. Warped CT images and contours were generated and their impact in adaptive radiotherapy was evaluated by DVH analysis for photon and proton treatments. Considerable discrepancies, related to the treatment planning dose distribution, might be found due to changes in patient’s anatomy. (author)

  13. Victoria's review of registration for health practitioners.

    Science.gov (United States)

    Scotts, H; Carter, M

    1988-01-01

    This article discusses some of the issues raised in the Interim Report of the current Review of Registration of Health Practitioners being conducted for the Victorian Health Department. The Report attempts to develop the framework in which the registration Boards will operate as part of a cohesive registration system. It proposed a mechanism and criteria for the registration of new groups as well as principles which can be applied to the ongoing review of each existing Board. The Review takes the perspective that registration of health practitioners carries with it both advantages and disadvantages for the general community. Under the proposed new system the controls exercised over health care providers by Registration Boards would be evaluated on the basis of to what extent the benefits to the public outweighed the potential costs. It is in this context that the Report addresses issues such as consumer complaints handling, registration of individual practitioners and controls over professional advertising and other business practices.

  14. Size variation and collapse of emphysema holes at inspiration and expiration CT scan: evaluation with modified length scale method and image co-registration.

    Science.gov (United States)

    Oh, Sang Young; Lee, Minho; Seo, Joon Beom; Kim, Namkug; Lee, Sang Min; Lee, Jae Seung; Oh, Yeon Mok

    2017-01-01

    A novel approach of size-based emphysema clustering has been developed, and the size variation and collapse of holes in emphysema clusters are evaluated at inspiratory and expiratory computed tomography (CT). Thirty patients were visually evaluated for the size-based emphysema clustering technique and a total of 72 patients were evaluated for analyzing collapse of the emphysema hole in this study. A new approach for the size differentiation of emphysema holes was developed using the length scale, Gaussian low-pass filtering, and iteration approach. Then, the volumetric CT results of the emphysema patients were analyzed using the new method, and deformable registration was carried out between inspiratory and expiratory CT. Blind visual evaluations of EI by two readers had significant correlations with the classification using the size-based emphysema clustering method ( r -values of reader 1: 0.186, 0.890, 0.915, and 0.941; reader 2: 0.540, 0.667, 0.919, and 0.942). The results of collapse of emphysema holes using deformable registration were compared with the pulmonary function test (PFT) parameters using the Pearson's correlation test. The mean extents of low-attenuation area (LAA), E1 (holes may be useful for understanding the dynamic collapse of emphysema and its functional relation.

  15. An evaluation of author productivity in international radiography journals 2004–2011

    Energy Technology Data Exchange (ETDEWEB)

    Snaith, Beverly A [Radiology Department, Mid Yorkshire Hospitals NHS Trust, Pinderfields Hospital, Aberford Road (United Kingdom)

    2013-09-15

    Radiography, the allied health profession, has changed beyond recognition over the last century; however, in academic terms radiography is a relatively young profession. It is therefore still establishing its professional knowledge base. This article uses peer-review author productivity distribution to evaluate its scholarly maturity. Four peer-reviewed journals in medical radiation sciences were examined over an 8-year period (2004–2011) and author productivity was compared to Lotka's law. Further analysis of the most prolific authors provided an evaluation of their characteristics. The 1306 unique authors contributed 835 articles during the study period. Of these, 1012 (77.5%) contributed only one article to the journals studied, with an inverse power relationship of author productivity. At the 0.1 level of significance, radiography does not fit Lotka's law (n = −2.334; c = 0.712; D{sub max} = 0.0627; Critical threshold = 0.0337). There was a significant correlation between the most prolific authors and collaboration (P = 0.002), although variation was noted in author discipline and location. The results of this study add to the discussion of radiography scholarship and demonstrate that the radiography authors have similar productivity distribution to other professions, but do not follow Lotka's law.

  16. An evaluation of author productivity in international radiography journals 2004–2011

    International Nuclear Information System (INIS)

    Snaith, Beverly A

    2013-01-01

    Radiography, the allied health profession, has changed beyond recognition over the last century; however, in academic terms radiography is a relatively young profession. It is therefore still establishing its professional knowledge base. This article uses peer-review author productivity distribution to evaluate its scholarly maturity. Four peer-reviewed journals in medical radiation sciences were examined over an 8-year period (2004–2011) and author productivity was compared to Lotka's law. Further analysis of the most prolific authors provided an evaluation of their characteristics. The 1306 unique authors contributed 835 articles during the study period. Of these, 1012 (77.5%) contributed only one article to the journals studied, with an inverse power relationship of author productivity. At the 0.1 level of significance, radiography does not fit Lotka's law (n = −2.334; c = 0.712; D max = 0.0627; Critical threshold = 0.0337). There was a significant correlation between the most prolific authors and collaboration (P = 0.002), although variation was noted in author discipline and location. The results of this study add to the discussion of radiography scholarship and demonstrate that the radiography authors have similar productivity distribution to other professions, but do not follow Lotka's law

  17. Automated image registration for FDOPA PET studies

    International Nuclear Information System (INIS)

    Kang-Ping Lin; Sung-Cheng Huang, Dan-Chu Yu; Melega, W.; Barrio, J.R.; Phelps, M.E.

    1996-01-01

    In this study, various image registration methods are investigated for their suitability for registration of L-6-[18F]-fluoro-DOPA (FDOPA) PET images. Five different optimization criteria including sum of absolute difference (SAD), mean square difference (MSD), cross-correlation coefficient (CC), standard deviation of pixel ratio (SDPR), and stochastic sign change (SSC) were implemented and Powell's algorithm was used to optimize the criteria. The optimization criteria were calculated either unidirectionally (i.e. only evaluating the criteria for comparing the resliced image 1 with the original image 2) or bidirectionally (i.e. averaging the criteria for comparing the resliced image 1 with the original image 2 and those for the sliced image 2 with the original image 1). Monkey FDOPA images taken at various known orientations were used to evaluate the accuracy of different methods. A set of human FDOPA dynamic images was used to investigate the ability of the methods for correcting subject movement. It was found that a large improvement in performance resulted when bidirectional rather than unidirectional criteria were used. Overall, the SAD, MSD and SDPR methods were found to be comparable in performance and were suitable for registering FDOPA images. The MSD method gave more adequate results for frame-to-frame image registration for correcting subject movement during a dynamic FDOPA study. The utility of the registration method is further demonstrated by registering FDOPA images in monkeys before and after amphetamine injection to reveal more clearly the changes in spatial distribution of FDOPA due to the drug intervention. (author)

  18. Evaluation of Industry Relationships Among Authors of Otolaryngology Clinical Practice Guidelines.

    Science.gov (United States)

    Horn, Jarryd; Checketts, Jake Xavier; Jawhar, Omar; Vassar, Matt

    2018-03-01

    Financial relationships between physicians and industry have influence on patient care. Therefore, organizations producing clinical practice guidelines (CPGs) must have policies limiting financial conflicts during guideline development. To evaluate payments received by physician authors of otolaryngology CPGs, compare disclosure statements for accuracy, and investigate the extent to which the American Academy of Otolaryngology-Head and Neck Surgery complied with standards for guideline development from the Institute of Medicine (IOM). This cross-sectional analysis retrieved CPGs from the American Academy of Otolaryngology-Head and Neck Surgery Foundation that were published or revised from January 1, 2013, through December 31, 2015, by 49 authors. Data were retrieved from December 1 through 31, 2016. Industry payments received by authors were extracted using the Centers for Medicare & Medicaid Services Open Payments database. The values and types of these payments were then evaluated and used to determine whether self-reported disclosure statements were accurate and whether guidelines adhered to applicable IOM standards. The monetary amounts and types of payments received by physicians who author otolaryngology guidelines and the accuracy of disclosure statements. Of the 49 physicians in this sample, 39 (80%) received an industry payment. Twenty-one authors (43%) accepted more than $1000; 12 (24%), more than $10 000; 7 (14%), more than $50 000; and 2 (4%), more than $100 000. Mean (SD) financial payments amounted to $18 431 ($53 459) per physician. Total reimbursement for all authors was $995 282. Disclosure statements disagreed with the Open Payments database for 3 authors, amounting to approximately $20 000 among them. Of the 3 IOM standards assessed, only 1 was consistently enforced. Some CPG authors failed to fully disclose all financial conflicts of interest, and most guideline development panels and chairpersons had conflicts. In addition

  19. Access Control with Delegated Authorization Policy Evaluation for Data-Driven Microservice Workflows

    Directory of Open Access Journals (Sweden)

    Davy Preuveneers

    2017-09-01

    Full Text Available Microservices offer a compelling competitive advantage for building data flow systems as a choreography of self-contained data endpoints that each implement a specific data processing functionality. Such a ‘single responsibility principle’ design makes them well suited for constructing scalable and flexible data integration and real-time data flow applications. In this paper, we investigate microservice based data processing workflows from a security point of view, i.e., (1 how to constrain data processing workflows with respect to dynamic authorization policies granting or denying access to certain microservice results depending on the flow of the data; (2 how to let multiple microservices contribute to a collective data-driven authorization decision and (3 how to put adequate measures in place such that the data within each individual microservice is protected against illegitimate access from unauthorized users or other microservices. Due to this multifold objective, enforcing access control on the data endpoints to prevent information leakage or preserve one’s privacy becomes far more challenging, as authorization policies can have dependencies and decision outcomes cross-cutting data in multiple microservices. To address this challenge, we present and evaluate a workflow-oriented authorization framework that enforces authorization policies in a decentralized manner and where the delegated policy evaluation leverages feature toggles that are managed at runtime by software circuit breakers to secure the distributed data processing workflows. The benefit of our solution is that, on the one hand, authorization policies restrict access to the data endpoints of the microservices, and on the other hand, microservices can safely rely on other data endpoints to collectively evaluate cross-cutting access control decisions without having to rely on a shared storage backend holding all the necessary information for the policy evaluation.

  20. Numerical methods for image registration

    CERN Document Server

    Modersitzki, Jan

    2003-01-01

    Based on the author's lecture notes and research, this well-illustrated and comprehensive text is one of the first to provide an introduction to image registration with particular emphasis on numerical methods in medical imaging. Ideal for researchers in industry and academia, it is also a suitable study guide for graduate mathematicians, computer scientists, engineers, medical physicists, and radiologists.Image registration is utilised whenever information obtained from different viewpoints needs to be combined or compared and unwanted distortion needs to be eliminated. For example, CCTV imag

  1. New York Power Authority/New York City Housing Authority refrigerator replacement program, first program year evaluation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, L.F.; Lewis, G. [Synertech Systems Corp., Syracuse, NY (United States); Pratt, R.G.; Miller, J. [Pacific Northwest National Lab., Richland, WA (United States)

    1997-08-01

    Acting as an energy services provider, the New York Power Authority (NYPA) has initiated a long-term project through which 20,000 refrigerators per year will be replaced with the most energy-efficient units possible in apartments managed by the New York City Housing Authority (NYCHA). Using bulk purchasing as an incentive to appliance manufacturers to produce energy-efficient refrigerators suitable for use in apartments, replaced in the first year of the program, which ended in December 1996. These units, kWh per year. Savings were determined by field testing and laboratory testing of 220 existing refrigerators and 56 newly-installed units. In the next program year, a 15.0-cubic-foot Maytag refrigerator, newly-designed in response to bulk purchasing incentives, is being installed. The new unit has a label rating of 437 kWh per year, 31 percent better than 1993 energy standards. Old refrigerators removed from apartments are {open_quotes}demanufactured{close_quotes} in an environmentally-appropriate way and both metals and refrigerants are recovered for reuse.

  2. Image Registration to Compensate for EPI Distortion in Patients with Brain Tumors: An Evaluation of Tract-Specific Effects.

    Science.gov (United States)

    Albi, Angela; Meola, Antonio; Zhang, Fan; Kahali, Pegah; Rigolo, Laura; Tax, Chantal M W; Ciris, Pelin Aksit; Essayed, Walid I; Unadkat, Prashin; Norton, Isaiah; Rathi, Yogesh; Olubiyi, Olutayo; Golby, Alexandra J; O'Donnell, Lauren J

    2018-03-01

    Diffusion magnetic resonance imaging (dMRI) provides preoperative maps of neurosurgical patients' white matter tracts, but these maps suffer from echo-planar imaging (EPI) distortions caused by magnetic field inhomogeneities. In clinical neurosurgical planning, these distortions are generally not corrected and thus contribute to the uncertainty of fiber tracking. Multiple image processing pipelines have been proposed for image-registration-based EPI distortion correction in healthy subjects. In this article, we perform the first comparison of such pipelines in neurosurgical patient data. Five pipelines were tested in a retrospective clinical dMRI dataset of 9 patients with brain tumors. Pipelines differed in the choice of fixed and moving images and the similarity metric for image registration. Distortions were measured in two important tracts for neurosurgery, the arcuate fasciculus and corticospinal tracts. Significant differences in distortion estimates were found across processing pipelines. The most successful pipeline used dMRI baseline and T2-weighted images as inputs for distortion correction. This pipeline gave the most consistent distortion estimates across image resolutions and brain hemispheres. Quantitative results of mean tract distortions on the order of 1-2 mm are in line with other recent studies, supporting the potential need for distortion correction in neurosurgical planning. Novel results include significantly higher distortion estimates in the tumor hemisphere and greater effect of image resolution choice on results in the tumor hemisphere. Overall, this study demonstrates possible pitfalls and indicates that care should be taken when implementing EPI distortion correction in clinical settings. Copyright © 2018 by the American Society of Neuroimaging.

  3. Towards clinical implementation of ultrafast combined kV-MV CBCT for IGRT of lung cancer. Evaluation of registration accuracy based on phantom study

    Energy Technology Data Exchange (ETDEWEB)

    Arns, Anna; Blessing, Manuel; Fleckenstein, Jens; Stsepankou, Dzmitry; Boda-Heggemann, Judit; Simeonova-Chergou, Anna; Hesser, Juergen; Lohr, Frank; Wenz, Frederik; Wertz, Hansjoerg [University Medical Center Mannheim, University of Heidelberg, Department of Radiation Oncology, Mannheim (Germany)

    2016-05-15

    Combined kV-MV cone-beam CT (CBCT) is a promising approach to accelerate imaging for patients with lung tumors treated with deep inspiration breath-hold. During a single breath-hold (15 s), a 3D kV-MV CBCT can be acquired, thus minimizing motion artifacts and increasing patient comfort. Prior to clinical implementation, positioning accuracy was evaluated and compared to clinically established imaging techniques. An inhomogeneous thorax phantom with four tumor-mimicking inlays was imaged in 10 predefined positions and registered to a planning CT. Novel kV-MV CBCT imaging (90 arc) was compared to clinically established kV-chest CBCT (360 ) as well as nonclinical kV-CBCT and low-dose MV-CBCT (each 180 ). Manual registration, automatic registration provided by the manufacturer and an additional in-house developed manufacturer-independent framework based on the MATLAB registration toolkit were applied. Systematic setup error was reduced to 0.05 mm by high-precision phantom positioning with optical tracking. Stochastic mean displacement errors were 0.5 ± 0.3 mm in right-left, 0.4 ± 0.4 mm in anteroposterior and 0.0 ± 0.4 mm in craniocaudal directions for kV-MV CBCT with manual registration (maximum errors of no more than 1.4 mm). Clinical kV-chest CBCT resulted in mean errors of 0.2 mm (other modalities: 0.4-0.8 mm). Similar results were achieved with both automatic registration methods. The comparison study of repositioning accuracy between novel kV-MV CBCT and clinically established volume imaging demonstrated that registration accuracy is maintained below 1 mm. Since imaging time is reduced to one breath-hold, kV-MV CBCT is ideal for image guidance, e.g., in lung stereotactic ablative radiotherapy. (orig.) [German] Kombiniertes kV-MV-Cone-Beam-CT (CBCT) ist ein vielversprechender Ansatz zur Beschleunigung der Bildgebung bei Patienten mit Lungentumoren, die mit wiederholter Atemanhaltetechnik in tiefer Inspiration behandelt werden. Waehrend einer einzigen

  4. Registration factors that limit international mobility of people holding physiotherapy qualifications: A systematic review.

    Science.gov (United States)

    Foo, Jonathan S; Storr, Michael; Maloney, Stephen

    2016-06-01

    There is no enforced international standardisation of the physiotherapy profession. Thus, registration is used in many countries to maintain standards of care and to protect the public. However, registration may also limit international workforce mobility. What is known about the professional registration factors that may limit the international mobility of people holding physiotherapy qualifications? Systematic review using an electronic database search and hand searching of the World Confederation for Physical Therapy and International Network of Physiotherapy Regulatory Authorities websites. Analysis was conducted using thematic analysis. 10 articles and eight websites were included from the search strategy. Data is representative of high-income English speaking countries. Four themes emerged regarding limitations to professional mobility: practice context, qualification recognition, verification of fitness to practice, and incidental limitations arising from the registration process. Professional mobility is limited by differences in physiotherapy education programmes, resulting in varying standards of competency. Thus, it is often necessary to verify clinical competencies through assessments, as well as determining professional attributes and ability to apply competencies in a different practice context, as part of the registration process. There has been little evaluation of registration practices, and at present, there is a need to re-evaluate current registration processes to ensure they are efficient and effective, thereby enhancing workforce mobility. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  5. Multimodal Registration of gated cardiac PET, CT and MR sequences

    International Nuclear Information System (INIS)

    Baty, X.

    2007-07-01

    The research described in this manuscript deals with the multimodal registration of cardiac images from Magnetic Resonance Imaging (MRI), Position Emission Tomography (PET) and Computerized Tomography (CT). All these modalities are gated to the Electrocardiogram (ECG) and provide information to evaluate cardiac function, and to diagnose and to follow-up cardiovascular pathologies. PET imaging allows the evaluation of ventricular function and MRI is a gold standard for the study of the left ventricular function. The goal of our registration process is to merge functional (from PET) and anatomical images (from CT and MRI). Our process is adapted to the modalities used and is divided in two steps: (i) a global rigid 3-dimensional model-based ICP (Iterative Closest Point) registration between CT and MR data and (ii) an iconic 2-dimensional registration based on Free Form Deformations and Mutual Information. This last step presents an original contribution by using a composite image of CT (which presents epicardic contours) and PET (where endocardic contours are partially visible) data to make mutual information more accurate in representing the similarity with the MR data. To speed up the whole process, we also present a transformation initialization scheme using displacement field obtained form MR data only. The obtained results have been evaluated by experts. (author)

  6. MO-AB-BRA-09: Temporally Realistic Manipulation a 4D Biomechanical Lung Phantom for Evaluation of Simultaneous Registration and Segmentation

    Energy Technology Data Exchange (ETDEWEB)

    Markel, D; Levesque, I R.; Larkin, J; Leger, P; El Naqa, I [McGill University, Montreal, QC (Canada)

    2015-06-15

    Purpose: To produce multi-modality compatible, realistic datasets for the joint evaluation of segmentation and registration with a reliable ground truth using a 4D biomechanical lung phantom. The further development of a computer controlled air flow system for recreation of real patient breathing patterns is incorporated for additional evaluation of motion prediction algorithms. Methods: A pair of preserved porcine lungs was pneumatically manipulated using an in-house computer controlled respirator. The respirator consisted of a set of bellows actuated by a 186 W computer controlled industrial motor. Patient breathing traces were recorded using a respiratory bellows belt during CT simulation and input into a control program incorporating a proportional-integral-derivative (PID) feedback controller in LabVIEW. Mock tumors were created using dual compartment vacuum sealed sea sponges. 65% iohexol,a gadolinium-based contrast agent and 18F-FDG were used to produce contrast and thus determine a segmentation ground truth. The intensity distributions of the compartments were then digitally matched for the final dataset. A bifurcation tracking pipeline provided a registration ground truth using the bronchi of the lung. The lungs were scanned using a GE Discovery-ST PET/CT scanner and a Phillips Panorama 0.23T MRI using a T1 weighted 3D fast field echo (FFE) protocol. Results: The standard deviation of the error between the patient breathing trace and the encoder feedback from the respirator was found to be ±4.2%. Bifurcation tracking error using CT (0.97×0.97×3.27 mm{sup 3} resolution) was found to be sub-voxel up to 7.8 cm displacement for human lungs and less than 1.32 voxel widths in any axis up to 2.3 cm for the porcine lungs. Conclusion: An MRI/PET/CT compatible anatomically and temporally realistic swine lung phantom was developed for the evaluation of simultaneous registration and segmentation algorithms. With the addition of custom software and mock tumors, the

  7. A multi-institution evaluation of deformable image registration algorithms for automatic organ delineation in adaptive head and neck radiotherapy

    International Nuclear Information System (INIS)

    Hardcastle, Nicholas; Kumar, Prashant; Oechsner, Markus; Richter, Anne; Song, Shiyu; Myers, Michael; Polat, Bülent; Bzdusek, Karl; Tomé, Wolfgang A; Cannon, Donald M; Brouwer, Charlotte L; Wittendorp, Paul WH; Dogan, Nesrin; Guckenberger, Matthias; Allaire, Stéphane; Mallya, Yogish

    2012-01-01

    Adaptive Radiotherapy aims to identify anatomical deviations during a radiotherapy course and modify the treatment plan to maintain treatment objectives. This requires regions of interest (ROIs) to be defined using the most recent imaging data. This study investigates the clinical utility of using deformable image registration (DIR) to automatically propagate ROIs. Target (GTV) and organ-at-risk (OAR) ROIs were non-rigidly propagated from a planning CT scan to a per-treatment CT scan for 22 patients. Propagated ROIs were quantitatively compared with expert physician-drawn ROIs on the per-treatment scan using Dice scores and mean slicewise Hausdorff distances, and center of mass distances for GTVs. The propagated ROIs were qualitatively examined by experts and scored based on their clinical utility. Good agreement between the DIR-propagated ROIs and expert-drawn ROIs was observed based on the metrics used. 94% of all ROIs generated using DIR were scored as being clinically useful, requiring minimal or no edits. However, 27% (12/44) of the GTVs required major edits. DIR was successfully used on 22 patients to propagate target and OAR structures for ART with good anatomical agreement for OARs. It is recommended that propagated target structures be thoroughly reviewed by the treating physician

  8. SU-F-J-98: Improvement and Evaluation Of Deformation Image Registration On Parotid Glands During Radiation Therapy for Nasopharyngeal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Xu, S [Tsinghua University, Beijing (China); PLA General Hospital, Beijing (China); Wu, Z; Liu, Y [Tsinghua University, Beijing (China); Liu, B; Li, Y; Zhou, F [Beihang University, Beijing (China); Gong, H; Qu, B [PLA General Hospital, Beijing (China)

    2016-06-15

    Purpose: To quantitatively evaluate the strategic innovation and accuracy variation of deformation registration algorithm for parotid glands using the similarity Dice coefficient during the course of radiation therapy (RT) for nasopharyngeal cancer (NPC). Methods: Daily MVCT data for 10 patients with pathologically proven nasopharyngeal cancers were analyzed. The data were acquired using tomotherapy (TomoTherapy, Accuray) at the PLA General Hospital. The prescription dose to the primary target was 70Gy in 33 fractions. Two kinds of contours for parotid glands on daily MVCTs were obtained by populating these contours from planning CTs to the daily CTs via rigid-body registration with or without the rotation shifts using the in-house tools and the Adaptive plan software (Adaptive Plan, TomoTherapy), and were edited manually if necessary. The diffeomorphic Demons algorithm developed in the in-house tool was used to propagate the parotid structures from the daily CTs to planning CTs. The differences of the mapped parotid contours in two methods were evaluated using Dice similarity index (DSI). Two-tailed t-test analysis was carried out to compare the DSI changes during the course of RT. Results: For 10 patient plans, the accuracy of deformation image registration (DIR) with the rotation shift was obviously better than those without the rotation shift. The Dice scores of the ipsi- and contra-lateral parotids for with and without the rotation shifts were found to be correlated with each other [0.904±0.031 vs 0.919±0.030 (p<0.001); 0.900±0.031 vs 0.910±0.032 (p<0.001)]. The Dice scores for the parotids have shown the reduction with the changes of parotid volumes during RT. The DSI values between the first and last fraction were 0.932±0.020 vs 0.899±0.030 in 10 patient plans. Conclusion: DIR was successfully improved using the strategic innovation for ART. And the decrease of DIR accuracy has also been found during the delivery of fractionated radiotherapy. This work

  9. Evaluation of how a real time pre-registration health care curricula was managed through the application of a newly designed Change Management Model: A qualitative case study.

    Science.gov (United States)

    Chowthi-Williams, Annette

    2018-02-01

    Curricula change in nurse education is of international importance. The pace of such change has been continuous and has triggered criticisms of inadequate preparation of practitioners. There are no change formulae for managing curricula change and despite a raft of change methods, globally change success remains low. A lack of a unified voice, undue focus on cognition, and arguably no existing models for academia and a literature gap contribute to change challenge. A new Change Management Model designed from research with emotion as its underpinning philosophy is evaluated. Evaluation of a newly designed Change Management Model through a real time pre-registration health care curricula change. A qualitative case study was adopted. The single case study was the new pre-registration health care curricula. This study took place in a Faculty of Health and Social care in one HEI in the UK. Four senior academics and fifteen academics across professions and specialisms involved in the curricula change took part in the study. The findings suggested that leadership operated differently throughout the organisation. Distributive and collective leadership created a critical mass of people to help deliver the new curricula but academics felt excluded at the strategic level. Emotion at the strategic level inhibited innovation but boosted engagement, emotional relationships and creativity at the operational level. Face to face communication was favoured for its emotional connection. A top down approach created an emotional disconnect and impacted inclusiveness, engagement, empowerment, vision and readiness for change. Testing the new model widely not only in organisations, practice and team changes but personal change in improving health and wellbeing could be beneficial. The continuing gap in knowledge on the link between emotion and curricula change, practice and organisational change and therapeutic value of the model also warrants further research. Crown Copyright © 2017

  10. An evaluation of a Books on Prescription scheme in a UK public library authority.

    Science.gov (United States)

    Furness, Rebecca; Casselden, Biddy

    2012-12-01

    This article discusses an evaluation of a Books on Prescription (BOP) scheme in a UK public library authority. The research was carried out by Rebecca Furness and submitted as a dissertation for the MSc Information and Library Management to Northumbria University. The dissertation was supervised by Biddy Casselden at Northumbria University and was awarded a distinction. The dissertation identified areas for development for BOP schemes and made specific recommendations that could make the schemes more accessible, enabling significant numbers of people to lead more fulfilling lives. Because this study focuses on mental health and the role that UK public libraries have in supporting well-being, it is a good illustration of the wide-ranging nature of subjects welcomed for the Dissertations into practice feature. © 2012 The authors. Health Information and Libraries Journal © 2012 Health Libraries Group.

  11. Cardiac dosimetric evaluation of deep inspiration breath-hold level variances using computed tomography scans generated from deformable image registration displacement vectors

    International Nuclear Information System (INIS)

    Harry, Taylor; Rahn, Doug; Semenov, Denis; Gu, Xuejun; Yashar, Catheryn; Einck, John; Jiang, Steve; Cerviño, Laura

    2016-01-01

    There is a reduction in cardiac dose for left-sided breast radiotherapy during treatment with deep inspiration breath-hold (DIBH) when compared with treatment with free breathing (FB). Various levels of DIBH may occur for different treatment fractions. Dosimetric effects due to this and other motions are a major component of uncertainty in radiotherapy in this setting. Recent developments in deformable registration techniques allow displacement vectors between various temporal and spatial patient representations to be digitally quantified. We propose a method to evaluate the dosimetric effect to the heart from variable reproducibility of DIBH by using deformable registration to create new anatomical computed tomography (CT) scans. From deformable registration, 3-dimensional deformation vectors are generated with FB and DIBH. The obtained deformation vectors are scaled to 75%, 90%, and 110% and are applied to the reference image to create new CT scans at these inspirational levels. The scans are then imported into the treatment planning system and dose calculations are performed. The average mean dose to the heart was 2.5 Gy (0.7 to 9.6 Gy) at FB, 1.2 Gy (0.6 to 3.8 Gy, p < 0.001) at 75% inspiration, 1.1 Gy (0.6 to 3.1 Gy, p = 0.004) at 90% inspiration, 1.0 Gy (0.6 to 3.0 Gy) at 100% inspiration or DIBH, and 1.0 Gy (0.6 to 2.8 Gy, p = 0.019) at 110% inspiration. The average mean dose to the left anterior descending artery (LAD) was 19.9 Gy (2.4 to 46.4 Gy), 8.6 Gy (2.0 to 43.8 Gy, p < 0.001), 7.2 Gy (1.9 to 40.1 Gy, p = 0.035), 6.5 Gy (1.8 to 34.7 Gy), and 5.3 Gy (1.5 to 31.5 Gy, p < 0.001), correspondingly. This novel method enables numerous anatomical situations to be mimicked and quantifies the dosimetric effect they have on a treatment plan.

  12. WE-AB-BRA-04: Evaluation of the Tumor Registration Error in Biopsy Procedures Performed Under Real Time PET/CT Guidance

    International Nuclear Information System (INIS)

    Fanchon, L; Apte, A; Dzyubak, O; Mageras, G; Yorke, E; Solomon, S; Kirov, A; Visvikis, D; Hatt, M

    2015-01-01

    Purpose: PET/CT guidance is used for biopsies of metabolically active lesions, which are not well seen on CT alone or to target the metabolically active tissue in tumor ablations. It has also been shown that PET/CT guided biopsies provide an opportunity to verify the location of the lesion border at the place of needle insertion. However the error in needle placement with respect to the metabolically active region may be affected by motion between the PET/CT scan performed at the start of the procedure and the CT scan performed with the needle in place and this error has not been previously quantified. Methods: Specimens from 31 PET/CT guided biopsies were investigated and correlated to the intraoperative PET scan under an IRB approved HIPAA compliant protocol. For 4 of the cases in which larger motion was suspected a second PET scan was obtained with the needle in place. The CT and the PET images obtained before and after the needle insertion were used to calculate the displacement of the voxels along the needle path. CTpost was registered to CTpre using a free form deformable registration and then fused with PETpre. The shifts between the PET image contours (42% of SUVmax) for PETpre and PETpost were obtained at the needle position. Results: For these extreme cases the displacement of the CT voxels along the needle path ranged from 2.9 to 8 mm with a mean of 5 mm. The shift of the PET image segmentation contours (42% of SUVmax) at the needle position ranged from 2.3 to 7 mm between the two scans. Conclusion: Evaluation of the mis-registration between the CT with the needle in place and the pre-biopsy PET can be obtained using deformable registration of the respective CT scans and can be used to indicate the need of a second PET in real-time. This work is supported in part by a grant from Biospace Lab, S.A

  13. Cardiac dosimetric evaluation of deep inspiration breath-hold level variances using computed tomography scans generated from deformable image registration displacement vectors

    Energy Technology Data Exchange (ETDEWEB)

    Harry, Taylor [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA (United States); Department of Radiation Medicine, Oregon Health and Science University, Portland, OR (United States); Department of Nuclear Engineering and Radiation Health Physics, Oregon State University, Corvallis, OR (United States); Rahn, Doug; Semenov, Denis [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA (United States); Gu, Xuejun [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Yashar, Catheryn; Einck, John [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA (United States); Jiang, Steve [Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX (United States); Cerviño, Laura, E-mail: lcervino@ucsd.edu [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA (United States)

    2016-04-01

    There is a reduction in cardiac dose for left-sided breast radiotherapy during treatment with deep inspiration breath-hold (DIBH) when compared with treatment with free breathing (FB). Various levels of DIBH may occur for different treatment fractions. Dosimetric effects due to this and other motions are a major component of uncertainty in radiotherapy in this setting. Recent developments in deformable registration techniques allow displacement vectors between various temporal and spatial patient representations to be digitally quantified. We propose a method to evaluate the dosimetric effect to the heart from variable reproducibility of DIBH by using deformable registration to create new anatomical computed tomography (CT) scans. From deformable registration, 3-dimensional deformation vectors are generated with FB and DIBH. The obtained deformation vectors are scaled to 75%, 90%, and 110% and are applied to the reference image to create new CT scans at these inspirational levels. The scans are then imported into the treatment planning system and dose calculations are performed. The average mean dose to the heart was 2.5 Gy (0.7 to 9.6 Gy) at FB, 1.2 Gy (0.6 to 3.8 Gy, p < 0.001) at 75% inspiration, 1.1 Gy (0.6 to 3.1 Gy, p = 0.004) at 90% inspiration, 1.0 Gy (0.6 to 3.0 Gy) at 100% inspiration or DIBH, and 1.0 Gy (0.6 to 2.8 Gy, p = 0.019) at 110% inspiration. The average mean dose to the left anterior descending artery (LAD) was 19.9 Gy (2.4 to 46.4 Gy), 8.6 Gy (2.0 to 43.8 Gy, p < 0.001), 7.2 Gy (1.9 to 40.1 Gy, p = 0.035), 6.5 Gy (1.8 to 34.7 Gy), and 5.3 Gy (1.5 to 31.5 Gy, p < 0.001), correspondingly. This novel method enables numerous anatomical situations to be mimicked and quantifies the dosimetric effect they have on a treatment plan.

  14. Assessment of rigid multi-modality image registration consistency using the multiple sub-volume registration (MSR) method

    International Nuclear Information System (INIS)

    Ceylan, C; Heide, U A van der; Bol, G H; Lagendijk, J J W; Kotte, A N T J

    2005-01-01

    Registration of different imaging modalities such as CT, MRI, functional MRI (fMRI), positron (PET) and single photon (SPECT) emission tomography is used in many clinical applications. Determining the quality of any automatic registration procedure has been a challenging part because no gold standard is available to evaluate the registration. In this note we present a method, called the 'multiple sub-volume registration' (MSR) method, for assessing the consistency of a rigid registration. This is done by registering sub-images of one data set on the other data set, performing a crude non-rigid registration. By analysing the deviations (local deformations) of the sub-volume registrations from the full registration we get a measure of the consistency of the rigid registration. Registration of 15 data sets which include CT, MR and PET images for brain, head and neck, cervix, prostate and lung was performed utilizing a rigid body registration with normalized mutual information as the similarity measure. The resulting registrations were classified as good or bad by visual inspection. The resulting registrations were also classified using our MSR method. The results of our MSR method agree with the classification obtained from visual inspection for all cases (p < 0.02 based on ANOVA of the good and bad groups). The proposed method is independent of the registration algorithm and similarity measure. It can be used for multi-modality image data sets and different anatomic sites of the patient. (note)

  15. Registration of Space Objects

    Science.gov (United States)

    Schmidt-Tedd, Bernhard

    2017-07-01

    Space objects are subject to registration in order to allocate "jurisdiction and control" over those objects in the sovereign-free environment of outer space. This approach is similar to the registration of ships in view of the high sea and for aircrafts with respect to the international airspace. Registration is one of the basic principles of space law, starting with UN General Assembly Resolution 1721 B (XVI) of December 20, 1961, followed by Resolution 1962 (XVIII) of December 13, 1963, then formulated in Article VIII of the Outer Space Treaty of 1967 and as specified in the Registration Convention of 1975. Registration of space objects can be seen today as a principle of customary international law, relevant for each spacefaring state. Registration is divided into a national and an international level. The State Party establishes a national registry for its space objects, and those registrations have to be communicated via diplomatic channel to the UN Register of space objects. This UN Register is handled by the UN Office for Outer Space Affairs (UNOOSA) and is an open source of information for space objects worldwide. Registration is linked to the so-called launching state of the relevant space object. There might be more than one launching state for the specific launch event, but only one state actor can register a specific space object. The state of registry gains "jurisdiction and control" over the space object and therefore no double registration is permissible. Based on the established UN Space Law, registration practice was subject to some adaptions due to technical developments and legal challenges. After the privatization of the major international satellite organizations, a number of non-registrations had to be faced. The state actors reacted with the UN Registration Practice Resolution of 2007 as elaborated in the Legal Subcommittee of UNCOPUOS, the Committee for the Peaceful Use of Outer Space. In this context an UNOOSA Registration Information

  16. Evaluating the accuracy of the XVI dual registration tool compared with manual soft tissue matching to localise tumour volumes for post-prostatectomy patients receiving radiotherapy

    International Nuclear Information System (INIS)

    Campbell, Amelia; Brown, Elizabeth; Pryor, David; Lehman, Margot; Owen, Rebecca; Bernard, Anne

    2015-01-01

    Cone beam computerised tomography (CBCT) enables soft tissue visualisation to optimise matching in the post-prostatectomy setting, but is associated with inter-observer variability. This study assessed the accuracy and consistency of automated soft tissue localisation using XVI's dual registration tool (DRT). Sixty CBCT images from ten post-prostatectomy patients were matched using: (i) the DRT and (ii) manual soft tissue registration by six radiation therapists (RTs). Shifts in the three Cartesian planes were recorded. The accuracy of the match was determined by comparing shifts to matches performed by two genitourinary radiation oncologists (ROs). A Bland–Altman method was used to assess the 95% levels of agreement (LoA). A clinical threshold of 3 mm was used to define equivalence between methods of matching. The 95% LoA between DRT-ROs in the superior/inferior, left/right and anterior/posterior directions were −2.21 to +3.18 mm, −0.77 to +0.84 mm, and −1.52 to +4.12 mm, respectively. The 95% LoA between RTs-ROs in the superior/inferior, left/right and anterior/posterior directions were −1.89 to +1.86 mm, −0.71 to +0.62 mm and −2.8 to +3.43 mm, respectively. Five DRT CBCT matches (8.33%) were outside the 3-mm threshold, all in the setting of bladder underfilling or rectal gas. The mean time for manual matching was 82 versus 65 s for DRT. XVI's DRT is comparable with RTs manually matching soft tissue on CBCT. The DRT can minimise RT inter-observer variability; however, involuntary bladder and rectal filling can influence the tools accuracy, highlighting the need for RT evaluation of the DRT match.

  17. Comprehensive evaluation of ten deformable image registration algorithms for contour propagation between CT and cone-beam CT images in adaptive head & neck radiotherapy.

    Science.gov (United States)

    Li, Xin; Zhang, Yuyu; Shi, Yinghua; Wu, Shuyu; Xiao, Yang; Gu, Xuejun; Zhen, Xin; Zhou, Linghong

    2017-01-01

    Deformable image registration (DIR) is a critical technic in adaptive radiotherapy (ART) for propagating contours between planning computerized tomography (CT) images and treatment CT/cone-beam CT (CBCT) images to account for organ deformation for treatment re-planning. To validate the ability and accuracy of DIR algorithms in organ at risk (OAR) contour mapping, ten intensity-based DIR strategies, which were classified into four categories-optical flow-based, demons-based, level-set-based and spline-based-were tested on planning CT and fractional CBCT images acquired from twenty-one head & neck (H&N) cancer patients who underwent 6~7-week intensity-modulated radiation therapy (IMRT). Three similarity metrics, i.e., the Dice similarity coefficient (DSC), the percentage error (PE) and the Hausdorff distance (HD), were employed to measure the agreement between the propagated contours and the physician-delineated ground truths of four OARs, including the vertebra (VTB), the vertebral foramen (VF), the parotid gland (PG) and the submandibular gland (SMG). It was found that the evaluated DIRs in this work did not necessarily outperform rigid registration. DIR performed better for bony structures than soft-tissue organs, and the DIR performance tended to vary for different ROIs with different degrees of deformation as the treatment proceeded. Generally, the optical flow-based DIR performed best, while the demons-based DIR usually ranked last except for a modified demons-based DISC used for CT-CBCT DIR. These experimental results suggest that the choice of a specific DIR algorithm depends on the image modality, anatomic site, magnitude of deformation and application. Therefore, careful examinations and modifications are required before accepting the auto-propagated contours, especially for automatic re-planning ART systems.

  18. Comprehensive evaluation of ten deformable image registration algorithms for contour propagation between CT and cone-beam CT images in adaptive head & neck radiotherapy.

    Directory of Open Access Journals (Sweden)

    Xin Li

    Full Text Available Deformable image registration (DIR is a critical technic in adaptive radiotherapy (ART for propagating contours between planning computerized tomography (CT images and treatment CT/cone-beam CT (CBCT images to account for organ deformation for treatment re-planning. To validate the ability and accuracy of DIR algorithms in organ at risk (OAR contour mapping, ten intensity-based DIR strategies, which were classified into four categories-optical flow-based, demons-based, level-set-based and spline-based-were tested on planning CT and fractional CBCT images acquired from twenty-one head & neck (H&N cancer patients who underwent 6~7-week intensity-modulated radiation therapy (IMRT. Three similarity metrics, i.e., the Dice similarity coefficient (DSC, the percentage error (PE and the Hausdorff distance (HD, were employed to measure the agreement between the propagated contours and the physician-delineated ground truths of four OARs, including the vertebra (VTB, the vertebral foramen (VF, the parotid gland (PG and the submandibular gland (SMG. It was found that the evaluated DIRs in this work did not necessarily outperform rigid registration. DIR performed better for bony structures than soft-tissue organs, and the DIR performance tended to vary for different ROIs with different degrees of deformation as the treatment proceeded. Generally, the optical flow-based DIR performed best, while the demons-based DIR usually ranked last except for a modified demons-based DISC used for CT-CBCT DIR. These experimental results suggest that the choice of a specific DIR algorithm depends on the image modality, anatomic site, magnitude of deformation and application. Therefore, careful examinations and modifications are required before accepting the auto-propagated contours, especially for automatic re-planning ART systems.

  19. WE-E-213CD-11: A New Automatically Generated Metric for Evaluating the Spatial Precision of Deformable Image Registrations: The Distance Discordance Metric.

    Science.gov (United States)

    Saleh, Z; Apte, A; Sharp, G; Deasy, J

    2012-06-01

    We propose a new metric called Distance Discordance (DD), which is defined as the distance between two anatomic points from two moving images, which are co-located on some reference image, when deformed onto another reference image. To demonstrate the concept of DD, we created a reference software phantom which contains two objects. The first object (1) consists of a hollow box with a fixed size core and variable wall thickness. The second object (2) consists of a solid box of fixed size and arbitrary location. 7 different variations of the fixed phantom were created. Each phantom was deformed onto every other phantom using two B-Spline DIR algorithms available in Elastix and Plastimatch. Voxels were sampled from the reference phantom [1], which were also deformed from moving phantoms [2…6], and we find the differences in their corresponding location on phantom [7]. Each voxel results in a distribution of DD values, which we call distance discordance histogram (DDH). We also demonstrate this concept in 8 Head & Neck patients. The two image registration algorithms produced two different DD results for the same phantom image set. The mean values of the DDH were slightly lower for Elastix (0-1.28 cm) as compared to the values produced by Plastimatch (0-1.43 cm). The combined DDH for the H&N patients followed a lognormal distribution with a mean of 0.45 cm and std. deviation of 0.42 cm. The proposed distance discordance (DD) metric is an easily interpretable, quantitative tool that can be used to evaluate the effect of inter-patient variability on the goodness of the registration in different parts of the patient anatomy. Therefore, it can be utilized to exclude certain images based on their DDH characteristics. In addition, this metric does not rely on 'ground truth' or the presence of contoured structures. Partially supported by NIH grant R01 CA85181. © 2012 American Association of Physicists in Medicine.

  20. Safety evaluation report on Tennessee Valley Authority: Watts Bar Nuclear Performance Plan

    International Nuclear Information System (INIS)

    1990-01-01

    This safety evaluation report on the information submitted by the Tennessee Valley Authority in its Nuclear Performance Plan for the Watts Bar Nuclear Plant and in supporting documents has been prepared by the US Nuclear Regulatory Commission staff. The plan addresses the plant-specific corrective actions as part of the recovery program for licensing of Unit 1. The staff will be monitoring and inspecting the implementation of the programs. The plan does not address all licensing matters that will be required for fuel load and operation of Unit 1. Those remaining licensing matters have been addressed in previous safety evaluations or will be addressed in accordance with routing NRC licensing practices. 97 refs

  1. Safety Evaluation report on Tennessee Valley Authority: Sequoyah nuclear performance plan

    International Nuclear Information System (INIS)

    1988-05-01

    This Safety Evaluation Report (SER) on the information submitted by the Tennessee Valley Authority (TVA) in its Sequoyah Nuclear Performance Plan, through Revision 2, and supporting documents has been prepared by the US Nuclear Regulatory Commission staff. The plan addresses the plant-specific concerns requiring resolution before startup of either of the Sequoyah units. In particular, the SER addresses required actions for Unit 2 restart. In many cases, the programmatic aspects for Unit 1 are identical to those for Unit 2; the staff will conduct inspections of implementation of those programs. Where the Unit 1 program is different, the staff evaluation will be provided in a supplement to this SER. On the basis of its review, the staff concludes that Sequoyah-specific issues have been resolved to the extent that would support restart of Sequoyah Unit 2

  2. Safety evaluation report on Tennessee Valley Authority: Browns Ferry nuclear performance plan

    International Nuclear Information System (INIS)

    1989-10-01

    This safety evaluation report (SER) on the information submitted by the Tennessee Valley Authority (TVA) in its Nuclear Performance Plan, through Revision 2, for the Browns Ferry Nuclear Plant and in supporting documents has been prepared by the US Nuclear Regulatory commission staff. The Browns Ferry Nuclear Plant consists of three boiling-water reactors at a site in Limestone County, Alabama. The plan addresses the plant-specific concerns requiring resolution before the startup of Unit 2. The staff will inspect implementation of those TVA programs that address these concerns. Where systems are common to Units 1 and 2 or to Units 2 and 3, the staff safety evaluations of those systems are included herein. 85 refs

  3. Evaluating a Collaborative Approach to Improve Prior Authorization Efficiency in the Treatment of Hepatitis C Virus.

    Science.gov (United States)

    Dunn, Emily E; Vranek, Kathryn; Hynicka, Lauren M; Gripshover, Janet; Potosky, Darryn; Mattingly, T Joseph

    A team-based approach to obtaining prior authorization approval was implemented utilizing a specialty pharmacy, a clinic-based pharmacy technician specialist, and a registered nurse to work with providers to obtain approval for medications for hepatitis C virus (HCV) infection. The objective of this study was to evaluate the time to approval for prescribed treatment of HCV infection. A retrospective observational study was conducted including patients treated for HCV infection by clinic providers who received at least 1 oral direct-acting antiviral HCV medication. Patients were divided into 2 groups, based on whether they were treated before or after the implementation of the team-based approach. Student t tests were used to compare average wait times before and after the intervention. The sample included 180 patients, 68 treated before the intervention and 112 patients who initiated therapy after. All patients sampled required prior authorization approval by a third-party payer to begin therapy. There was a statistically significant reduction (P = .02) in average wait time in the postintervention group (15.6 ± 12.1 days) once adjusted using dates of approval. Pharmacy collaboration may provide increases in efficiency in provider prior authorization practices and reduced wait time for patients to begin treatment.

  4. SU-E-J-102: Performance Variations Among Clinically Available Deformable Image Registration Tools in Adaptive Radiotherapy: How Should We Evaluate and Interpret the Result?

    International Nuclear Information System (INIS)

    Nie, K; Pouliot, J; Smith, E; Chuang, C

    2015-01-01

    Purpose: To evaluate the performance variations in commercial deformable image registration (DIR) tools for adaptive radiation therapy. Methods: Representative plans from three different anatomical sites, prostate, head-and-neck (HN) and cranial spinal irradiation (CSI) with L-spine boost, were included. Computerized deformed CT images were first generated using virtual DIR QA software (ImSimQA) for each case. The corresponding transformations served as the “reference”. Three commercial software packages MIMVista v5.5 and MIMMaestro v6.0, VelocityAI v2.6.2, and OnQ rts v2.1.15 were tested. The warped contours and doses were compared with the “reference” and among each other. Results: The performance in transferring contours was comparable among all three tools with an average DICE coefficient of 0.81 for all the organs. However, the performance of dose warping accuracy appeared to rely on the evaluation end points. Volume based DVH comparisons were not sensitive enough to illustrate all the detailed variations while isodose assessment on a slice-by-slice basis could be tedious. Point-based evaluation was over-sensitive by having up to 30% hot/cold-spot differences. If adapting the 3mm/3% gamma analysis into the evaluation of dose warping, all three algorithms presented a reasonable level of equivalency. One algorithm had over 10% of the voxels not meeting this criterion for the HN case while another showed disagreement for the CSI case. Conclusion: Overall, our results demonstrated that evaluation based only on the performance of contour transformation could not guarantee the accuracy in dose warping. However, the performance of dose warping accuracy relied on the evaluation methodologies. Nevertheless, as more DIR tools are available for clinical use, the performance could vary at certain degrees. A standard quality assurance criterion with clinical meaning should be established for DIR QA, similar to the gamma index concept, in the near future

  5. SU-E-J-109: Evaluation of Deformable Accumulated Parotid Doses Using Different Registration Algorithms in Adaptive Head and Neck Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Xu, S [Key Laboratory of Particle & Radiation Imaging (Tsinghua University), Ministry of Education, Beijing, 100084 China (China); Chinese PLA General Hospital, Beijing, 100853 China (China); Liu, B [Image processing center, Beihang University, Beijing, 100191 China (China)

    2015-06-15

    Purpose: Three deformable image registration (DIR) algorithms are utilized to perform deformable dose accumulation for head and neck tomotherapy treatment, and the differences of the accumulated doses are evaluated. Methods: Daily MVCT data for 10 patients with pathologically proven nasopharyngeal cancers were analyzed. The data were acquired using tomotherapy (TomoTherapy, Accuray) at the PLA General Hospital. The prescription dose to the primary target was 70Gy in 33 fractions.Three DIR methods (B-spline, Diffeomorphic Demons and MIMvista) were used to propagate parotid structures from planning CTs to the daily CTs and accumulate fractionated dose on the planning CTs. The mean accumulated doses of parotids were quantitatively compared and the uncertainties of the propagated parotid contours were evaluated using Dice similarity index (DSI). Results: The planned mean dose of the ipsilateral parotids (32.42±3.13Gy) was slightly higher than those of the contralateral parotids (31.38±3.19Gy)in 10 patients. The difference between the accumulated mean doses of the ipsilateral parotids in the B-spline, Demons and MIMvista deformation algorithms (36.40±5.78Gy, 34.08±6.72Gy and 33.72±2.63Gy ) were statistically significant (B-spline vs Demons, P<0.0001, B-spline vs MIMvista, p =0.002). And The difference between those of the contralateral parotids in the B-spline, Demons and MIMvista deformation algorithms (34.08±4.82Gy, 32.42±4.80Gy and 33.92±4.65Gy ) were also significant (B-spline vs Demons, p =0.009, B-spline vs MIMvista, p =0.074). For the DSI analysis, the scores of B-spline, Demons and MIMvista DIRs were 0.90, 0.89 and 0.76. Conclusion: Shrinkage of parotid volumes results in the dose increase to the parotid glands in adaptive head and neck radiotherapy. The accumulated doses of parotids show significant difference using the different DIR algorithms between kVCT and MVCT. Therefore, the volume-based criterion (i.e. DSI) as a quantitative evaluation of

  6. Fusion of dynamic contrast-enhanced magnetic resonance mammography at 3.0 T with X-ray mammograms: Pilot study evaluation using dedicated semi-automatic registration software

    Energy Technology Data Exchange (ETDEWEB)

    Dietzel, Matthias, E-mail: dietzelmatthias2@hotmail.com [Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena (Germany); Hopp, Torsten; Ruiter, Nicole [Karlsruhe Institute of Technology (KIT), Institute for Data Processing and Electronics, Postfach 3640, D-76021 Karlsruhe (Germany); Zoubi, Ramy [Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena (Germany); Runnebaum, Ingo B. [Clinic of Gynecology and Obstetrics, Friedrich-Schiller-University Jena, Bachstrasse 18, D-07743 Jena (Germany); Kaiser, Werner A. [Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena (Germany); Medical School, University of Harvard, 25 Shattuck Street, Boston, MA 02115 (United States); Baltzer, Pascal A.T. [Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena (Germany)

    2011-08-15

    Rationale and objectives: To evaluate the semi-automatic image registration accuracy of X-ray-mammography (XR-M) with high-resolution high-field (3.0 T) MR-mammography (MR-M) in an initial pilot study. Material and methods: MR-M was acquired on a high-field clinical scanner at 3.0 T (T1-weighted 3D VIBE {+-} Gd). XR-M was obtained with state-of-the-art full-field digital systems. Seven patients with clearly delineable mass lesions >10 mm both in XR-M and MR-M were enrolled (exclusion criteria: previous breast surgery; surgical intervention between XR-M and MR-M). XR-M and MR-M were matched using a dedicated image-registration algorithm allowing semi-automatic non-linear deformation of MR-M based on finite-element modeling. To identify registration errors (RE) a virtual craniocaudal 2D mammogram was calculated by the software from MR-M (with and w/o Gadodiamide/Gd) and matched with corresponding XR-M. To quantify REs the geometric center of the lesions in the virtual vs. conventional mammogram were subtracted. The robustness of registration was quantified by registration of X-MRs to both MR-Ms with and w/o Gadodiamide. Results: Image registration was performed successfully for all patients. Overall RE was 8.2 mm (1 min after Gd; confidence interval/CI: 2.0-14.4 mm, standard deviation/SD: 6.7 mm) vs. 8.9 mm (no Gd; CI: 4.0-13.9 mm, SD: 5.4 mm). The mean difference between pre- vs. post-contrast was 0.7 mm (SD: 1.9 mm). Conclusion: Image registration of high-field 3.0 T MR-mammography with X-ray-mammography is feasible. For this study applying a high-resolution protocol at 3.0 T, the registration was robust and the overall registration error was sufficient for clinical application.

  7. Fusion of dynamic contrast-enhanced magnetic resonance mammography at 3.0 T with X-ray mammograms: Pilot study evaluation using dedicated semi-automatic registration software

    International Nuclear Information System (INIS)

    Dietzel, Matthias; Hopp, Torsten; Ruiter, Nicole; Zoubi, Ramy; Runnebaum, Ingo B.; Kaiser, Werner A.; Baltzer, Pascal A.T.

    2011-01-01

    Rationale and objectives: To evaluate the semi-automatic image registration accuracy of X-ray-mammography (XR-M) with high-resolution high-field (3.0 T) MR-mammography (MR-M) in an initial pilot study. Material and methods: MR-M was acquired on a high-field clinical scanner at 3.0 T (T1-weighted 3D VIBE ± Gd). XR-M was obtained with state-of-the-art full-field digital systems. Seven patients with clearly delineable mass lesions >10 mm both in XR-M and MR-M were enrolled (exclusion criteria: previous breast surgery; surgical intervention between XR-M and MR-M). XR-M and MR-M were matched using a dedicated image-registration algorithm allowing semi-automatic non-linear deformation of MR-M based on finite-element modeling. To identify registration errors (RE) a virtual craniocaudal 2D mammogram was calculated by the software from MR-M (with and w/o Gadodiamide/Gd) and matched with corresponding XR-M. To quantify REs the geometric center of the lesions in the virtual vs. conventional mammogram were subtracted. The robustness of registration was quantified by registration of X-MRs to both MR-Ms with and w/o Gadodiamide. Results: Image registration was performed successfully for all patients. Overall RE was 8.2 mm (1 min after Gd; confidence interval/CI: 2.0-14.4 mm, standard deviation/SD: 6.7 mm) vs. 8.9 mm (no Gd; CI: 4.0-13.9 mm, SD: 5.4 mm). The mean difference between pre- vs. post-contrast was 0.7 mm (SD: 1.9 mm). Conclusion: Image registration of high-field 3.0 T MR-mammography with X-ray-mammography is feasible. For this study applying a high-resolution protocol at 3.0 T, the registration was robust and the overall registration error was sufficient for clinical application.

  8. Safety evaluation report on Tennessee Valley Authority: Browns Ferry Nuclear Performance Plan

    International Nuclear Information System (INIS)

    1991-01-01

    This safety evaluation report (SER) was prepared by the US Nuclear Regulatory Commission (NRC) staff and represents the second and last supplement (SSER 2) to the staff's original SER published as Volume 3 of NUREG-1232 in April 1989. Supplement 1 of Volume 3 of NUREG-1232 (SSER 1) was published in October 1989. Like its predecessors, SSER 2 is composed of numerous safety evaluations by the staff regarding specific elements contained in the Browns Ferry Nuclear Performance Plan (BFNPP), Volume 3 (up to and including Revision 2), submitted by the Tennessee Valley Authority (TVA) for the Browns Ferry Nuclear Plant (BFN). The Browns Ferry Nuclear Plant consists of three boiling-water reactors (BWRs) at a site in Limestone County, Alabama. The BFNPP describes the corrective action plans and commitments made by TVA to resolve deficiencies with its nuclear programs before the startup of Unit 2. The staff has inspected and will continue to inspect TVA's implementation of these BFNPP corrective action plans that address staff concerns about TVA's nuclear program. SSER 2 documents the NRC staff's safety evaluations and conclusions for those elements of the BFNPP that were not previously addressed by the staff or that remained open as a result of unresolved issues identified by the staff in previous SERs and inspections

  9. The catcher in the why: developing an evidence-based approach to the organization, delivery and evaluation of pre-registration nurse educational programmes.

    Science.gov (United States)

    Warne, T; Holland, K; McAndrew, S

    2011-03-01

    Changes to the pedagogy of pre-registration nurse education and training have become a global phenomenon. However, the evidence base to inform responses to these changes and the impact on nursing practice is limited. This paper explores the outcomes of an innovative approach aimed at ensuring responses to these drivers for change, particularly in curriculum development, the organisation, management and delivery of programmes and the enhancement of the student experience, are evidence based. This paper reports on an organisational change project undertaken in a School of Nursing in the North West of England, UK. The project involved 12 interrelated work streams used to explore aspects of the student journey from recruitment through progression to eventual employment. An evidence base was developed through a methodological bricolage that drew upon a robust and authentic mixture of systematic literature reviews, contemporaneous analysis of educational practice and evaluation of the student experience. This was used to underpin the decision making processes required to promote innovation in programme design, to increase the involvement of students in the facilitation and evaluation of their learning experiences, and helped shape the organisational changes required for embedding an evidenced-based culture in the School. Consistent and transformational leadership has been key to the project's success in communicating and managing the changes. Copyright © 2010 Elsevier Ltd. All rights reserved.

  10. Locally orderless registration code

    DEFF Research Database (Denmark)

    2012-01-01

    This is code for the TPAMI paper "Locally Orderless Registration". The code requires intel threadding building blocks installed and is provided for 64 bit on mac, linux and windows.......This is code for the TPAMI paper "Locally Orderless Registration". The code requires intel threadding building blocks installed and is provided for 64 bit on mac, linux and windows....

  11. Information from the Registration Service

    CERN Multimedia

    GS Department

    2011-01-01

    Please note that the Registration Service (Bldg 55-1st floor) will be exceptionally open during the annual end of year closure from 10:00 to 12:00 on the following days: 22, 23, 26, 27,28, 29 et 30 December 2011 and 2,3, et 4 January 2012. All the activities related to the Registration Service will be operational: registration for contractors’ personnel; registrations for professional visits; access cards; car stickers; biometric registration. The Registration Service

  12. Evaluation of deformable image registration for contour propagation between CT and cone-beam CT images in adaptive head and neck radiotherapy.

    Science.gov (United States)

    Li, X; Zhang, Y Y; Shi, Y H; Zhou, L H; Zhen, X

    2016-04-29

    Deformable image registration (DIR) is a critical technic in adaptive radiotherapy (ART) to propagate contours between planning computerized tomography (CT) images and treatment CT/Cone-beam CT (CBCT) image to account for organ deformation for treatment re-planning. To validate the ability and accuracy of DIR algorithms in organ at risk (OAR) contours mapping, seven intensity-based DIR strategies are tested on the planning CT and weekly CBCT images from six Head & Neck cancer patients who underwent a 6 ∼ 7 weeks intensity-modulated radiation therapy (IMRT). Three similarity metrics, i.e. the Dice similarity coefficient (DSC), the percentage error (PE) and the Hausdorff distance (HD), are employed to measure the agreement between the propagated contours and the physician delineated ground truths. It is found that the performance of all the evaluated DIR algorithms declines as the treatment proceeds. No statistically significant performance difference is observed between different DIR algorithms (p> 0.05), except for the double force demons (DFD) which yields the worst result in terms of DSC and PE. For the metric HD, all the DIR algorithms behaved unsatisfactorily with no statistically significant performance difference (p= 0.273). These findings suggested that special care should be taken when utilizing the intensity-based DIR algorithms involved in this study to deform OAR contours between CT and CBCT, especially for those organs with low contrast.

  13. Frameless image registration of X-ray CT and SPECT by volume matching

    International Nuclear Information System (INIS)

    Tanaka, Yuko; Kihara, Tomohiko; Yui, Nobuharu; Kinoshita, Fujimi; Kamimura, Yoshitsugu; Yamada, Yoshifumi.

    1998-01-01

    Image registration of functional (SPECT) and morphological (X-ray CT/MRI) images is studied in order to improve the accuracy and the quantity of the image diagnosis. We have developed a new frameless registration method of X-ray CT and SPECT image using transmission CT image acquired for absorption correction of SPECT images. This is the automated registration method and calculates the transformation matrix between the two coordinate systems of image data by the optimization method. This registration method is based on the similar physical property of X-ray CT and transmission CT image. The three-dimensional overlap of the bone region is used for image matching. We verified by a phantom test that it can provide a good result of within two millimeters error. We also evaluated visually the accuracy of the registration method by the application study of SPECT, X-ray CT, and transmission CT head images. This method can be carried out accurately without any frames. We expect this registration method becomes an efficient tool to improve image diagnosis and medical treatment. (author)

  14. Evaluating the extent of cell death in 3D high frequency ultrasound by registration with whole-mount tumor histopathology

    International Nuclear Information System (INIS)

    Vlad, Roxana M.; Kolios, Michael C.; Moseley, Joanne L.; Czarnota, Gregory J.; Brock, Kristy K.

    2010-01-01

    Purpose: High frequency ultrasound imaging, 10-30 MHz, has the capability to assess tumor response to radiotherapy in mouse tumors as early as 24 h after treatment administration. The advantage of this technique is that the image contrast is generated by changes in the physical properties of dying cells. Therefore, a subject can be imaged before and multiple times during the treatment without the requirement of injecting specialized contrast agents. This study is motivated by a need to provide metrics of comparison between the volume and localization of cell death, assessed from histology, with the volume and localization of cell death surrogate, assessed as regions with increased echogeneity from ultrasound images. Methods: The mice were exposed to radiation doses of 2, 4, and 8 Gy. Ultrasound images were collected from each tumor before and 24 h after exposure to radiation using a broadband 25 MHz center frequency transducer. After radiotherapy, tumors exhibited hyperechoic regions in ultrasound images that corresponded to areas of cell death in histology. The ultrasound and histological images were rigidly registered. The tumors and regions of cell death were manually outlined on histological images. Similarly, the tumors and hyperechoic regions were outlined on the ultrasound images. Each set of contours was converted to a volumetric mesh in order to compare the volumes and the localization of cell death in histological and ultrasound images. Results: A shrinkage factor of 17±2% was calculated from the difference in the tumor volumes evaluated from histological and ultrasound images. This was used to correct the tumor and cell death volumes assessed from histology. After this correction, the average absolute difference between the volume of cell death assessed from ultrasound and histological images was 11±14% and the volume overlap was 70±12%. Conclusions: The method provided metrics of comparison between the volume of cell death assessed from histology and

  15. TU-B-19A-01: Image Registration II: TG132-Quality Assurance for Image Registration

    International Nuclear Information System (INIS)

    Brock, K; Mutic, S

    2014-01-01

    AAPM Task Group 132 was charged with a review of the current approaches and solutions for image registration in radiotherapy and to provide recommendations for quality assurance and quality control of these clinical processes. As the results of image registration are always used as the input of another process for planning or delivery, it is important for the user to understand and document the uncertainty associate with the algorithm in general and the Result of a specific registration. The recommendations of this task group, which at the time of abstract submission are currently being reviewed by the AAPM, include the following components. The user should understand the basic image registration techniques and methods of visualizing image fusion. The disclosure of basic components of the image registration by commercial vendors is critical in this respect. The physicists should perform end-to-end tests of imaging, registration, and planning/treatment systems if image registration is performed on a stand-alone system. A comprehensive commissioning process should be performed and documented by the physicist prior to clinical use of the system. As documentation is important to the safe implementation of this process, a request and report system should be integrated into the clinical workflow. Finally, a patient specific QA practice should be established for efficient evaluation of image registration results. The implementation of these recommendations will be described and illustrated during this educational session. Learning Objectives: Highlight the importance of understanding the image registration techniques used in their clinic. Describe the end-to-end tests needed for stand-alone registration systems. Illustrate a comprehensive commissioning program using both phantom data and clinical images. Describe a request and report system to ensure communication and documentation. Demonstrate an clinically-efficient patient QA practice for efficient evaluation of image

  16. Deformable Registration for Longitudinal Breast MRI Screening.

    Science.gov (United States)

    Mehrabian, Hatef; Richmond, Lara; Lu, Yingli; Martel, Anne L

    2018-04-13

    MRI screening of high-risk patients for breast cancer provides very high sensitivity, but with a high recall rate and negative biopsies. Comparing the current exam to prior exams reduces the number of follow-up procedures requested by radiologists. Such comparison, however, can be challenging due to the highly deformable nature of breast tissues. Automated co-registration of multiple scans has the potential to aid diagnosis by providing 3D images for side-by-side comparison and also for use in CAD systems. Although many deformable registration techniques exist, they generally have a large number of parameters that need to be optimized and validated for each new application. Here, we propose a framework for such optimization and also identify the optimal input parameter set for registration of 3D T 1 -weighted MRI of breast using Elastix, a widely used and freely available registration tool. A numerical simulation study was first conducted to model the breast tissue and its deformation through finite element (FE) modeling. This model generated the ground truth for evaluating the registration accuracy by providing the deformation of each voxel in the breast volume. An exhaustive search was performed over various values of 7 registration parameters (4050 different combinations of parameters were assessed) and the optimum parameter set was determined. This study showed that there was a large variation in the registration accuracy of different parameter sets ranging from 0.29 mm to 2.50 mm in median registration error and 3.71 mm to 8.90 mm in 95 percentile of the registration error. Mean registration errors of 0.32 mm, 0.29 mm, and 0.30 mm and 95 percentile errors of 3.71 mm, 5.02 mm, and 4.70 mm were obtained by the three best parameter sets. The optimal parameter set was applied to consecutive breast MRI scans of 13 patients. A radiologist identified 113 landmark pairs (~ 11 per patient) which were used to assess registration accuracy. The results demonstrated that

  17. Markerless laser registration in image-guided oral and maxillofacial surgery.

    Science.gov (United States)

    Marmulla, Rüdiger; Lüth, Tim; Mühling, Joachim; Hassfeld, Stefan

    2004-07-01

    The use of registration markers in computer-assisted surgery is combined with high logistic costs and efforts. Markerless patient registration using laser scan surface registration techniques is a new challenging method. The present study was performed to evaluate the clinical accuracy in finding defined target points within the surgical site after markerless patient registration in image-guided oral and maxillofacial surgery. Twenty consecutive patients with different cranial diseases were scheduled for computer-assisted surgery. Data set alignment between the surgical site and the computed tomography (CT) data set was performed by markerless laser scan surface registration of the patient's face. Intraoral rigidly attached registration markers were used as target points, which had to be detected by an infrared pointer. The Surgical Segment Navigator SSN++ has been used for all procedures. SSN++ is an investigative product based on the SSN system that had previously been developed by the presenting authors with the support of Carl Zeiss (Oberkochen, Germany). SSN++ is connected to a Polaris infrared camera (Northern Digital, Waterloo, Ontario, Canada) and to a Minolta VI 900 3D digitizer (Tokyo, Japan) for high-resolution laser scanning. Minimal differences in shape between the laser scan surface and the surface generated from the CT data set could be detected. Nevertheless, high-resolution laser scan of the skin surface allows for a precise patient registration (mean deviation 1.1 mm, maximum deviation 1.8 mm). Radiation load, logistic costs, and efforts arising from the planning of computer-assisted surgery of the head can be reduced because native (markerless) CT data sets can be used for laser scan-based surface registration.

  18. The MINT project--an evaluation of the impact of midwife teachers on the outcomes of pre-registration midwifery education in the UK.

    Science.gov (United States)

    Fraser, Diane M; Avis, Mark; Mallik, Maggie

    2013-01-01

    to explore the contribution of midwife teachers in preparing student midwives for competent practice. a three phase design using qualitative and quantitative approaches. Phase one involved UK wide on-line questionnaire surveys, phase two was a case study method in six UK approved education institutions and phase three was a diary study with newly qualified midwives. phase one included all UK Lead Midwives for Education (LMEs), midwife teachers and Local Supervising Authority Midwifery Officers; phase two participants were three year and shortened programme student midwives, midwife teachers, LMEs and programme leads from each of the four countries; and phase three included a sample of newly qualified midwives graduating from the case study sites and their preceptors and supervisors of midwives. midwife teachers were valued for their unique and crucial role in supporting the application of knowledge to midwifery practice. Visibility and credibility were two key concepts that can explain the unique contribution of midwife teachers. These concepts included being able to support skills acquisition, understanding of contemporary midwifery practice, having a role in practice contexts and able to offer personal support. Visibility of teachers in practice was vital for students and mentors to assist students put their learning into practice and monitor learning and assessment decisions. given the complexity of midwifery education a team approach is essential in ensuring the effectiveness of these programmes. This requires a sufficient differentiation of midwife teacher roles to deliver the pre-registration curriculum. A set of resource quality indicators is proposed to support midwife teacher teams achieving sufficient clinical and academic expertise to deliver effective education programmes. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. Preliminary study of lateral cerebral angiography with reverse rotation in the digital image registration and subtraction

    International Nuclear Information System (INIS)

    Shen Zhenglin; Liu Dongyang; Shen Zhenghai; Li Shuping; Zhang Ziyan; Wu Yongjuan; Liu Peijun

    2012-01-01

    Objective: Investigate the value and feasibility of image registration with reverse rotation in lateral cerebral DSA. Methods: (1) Experimental study: the target images were subtracted directly, and subtracted again after reverse rotation. Software of registration and subtraction with reverse rotation edited by the author utilizing Visual Basic. The function of the automatic angle detection by the software were evaluated to see whether it detected the angle of line. The subtraction function of DSA by the software was evaluated. (2) Clinical retrospective study: the untreated mask and target images of 15 patients with motion along vertical axis during lateral cerebral DSA were uploaded to the software. The target images were processed with and without the software to get two sets of images. (3) Evaluation: four experienced radiologists read and compared the two sets of the images,and graded their findings. Results: (1) The automatic detection by the software suggested that the target images should be rotated counterclockwise 1.3°. The subtraction result of the software was satisfactory. (2) In the 15 sets of images, there were only three sets of images deemed optimal after traditional subtraction. After reverse rotation, artifacts were significantly reduced and the image sharper. There were ten cases with significant artifacts after traditional subtraction, and those images were sharper and showed more peripheral vessels after reverse rotation. The traditional subtraction images of two sets could not be interpreted,the reverse rotation registration images reached the diagnostic quality. (3) Subjective evaluation: there were more information and less noise and distortion in the registration images with reverse rotation than in the traditional subtraction. But the image resolution decreased slightly after reverse rotation registration. Conclusion: The registration of digital angiography with reverse rotation can improve the image quality in lateral cerebral DSA

  20. JALFHCC - Patient Registration Service

    Data.gov (United States)

    Department of Veterans Affairs — The Captain James A. Lovell Federal Health Care Center (JALFHCC) Patient Registration Service supports the operation of the first VA/Navy Federal Health Care Center...

  1. Visitor Registration System

    Data.gov (United States)

    US Agency for International Development — Visitor Registration System (VRS) streamlines visitor check-in and check-out process for expediting visitors into USAID. The system captures visitor information...

  2. Pesticide Registration Information System

    Data.gov (United States)

    U.S. Environmental Protection Agency — PRISM provides an integrated, web portal for all pesticide related data, communications, registrations and transactions for OPP and its stakeholders, partners and...

  3. Author Guidelines

    Directory of Open Access Journals (Sweden)

    Chief Editor

    2016-06-01

    Full Text Available AUTHOR GUIDELINES Indian Journal of Community Health (IJCH accepts only online submission of manuscript(s by using Open Journal software (OJS at http://www.iapsmupuk.org/journal/index.php/IJCH/login Online SubmissionsAlready have a Username/Password for Indian Journal of Community Health (IJCH? GO TO LOGINNeed a Username/Password?GO TO REGISTRATIONNote: Registration and login are required to submit items online and to track the status of current submissions.Author GuidelinesIJCH strictly adheres on the recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals as per the standard universal guidelines given by International Committee of Medical Journal Editors (ICMJE - Recommendations for Uniform Requirements for Manuscripts. Authors are requested to visit http://www.icmje.org/index.html before making online submission of their manuscript(s. http://www.icmje.org/recommendations/browse/manuscript-preparation/preparing-for-submission.html Preparing for SubmissionGeneral PrinciplesReporting GuidelinesManuscript SectionsTitle PageAbstractIntroductionMethodsResultsDiscussionReferencesTablesIllustrations (FiguresUnits of MeasurementAbbreviations and Symbols 1. General PrinciplesThe text of articles reporting original research is usually divided into Introduction, Methods, Results, and Discussion sections. This so-called “IMRAD” structure is not an arbitrary publication format but a reflection of the process of scientific discovery. Articles often need subheadings within these sections to further organize their content. Other types of articles, such as meta-analyses, may require different formats, while case reports, narrative reviews, and editorials may have less structured or unstructured formats.Electronic formats have created opportunities for adding details or sections, layering information, cross-linking, or extracting portions of articles in electronic versions. Supplementary electronic

  4. Deformable image registration using convolutional neural networks

    Science.gov (United States)

    Eppenhof, Koen A. J.; Lafarge, Maxime W.; Moeskops, Pim; Veta, Mitko; Pluim, Josien P. W.

    2018-03-01

    Deformable image registration can be time-consuming and often needs extensive parameterization to perform well on a specific application. We present a step towards a registration framework based on a three-dimensional convolutional neural network. The network directly learns transformations between pairs of three-dimensional images. The outputs of the network are three maps for the x, y, and z components of a thin plate spline transformation grid. The network is trained on synthetic random transformations, which are applied to a small set of representative images for the desired application. Training therefore does not require manually annotated ground truth deformation information. The methodology is demonstrated on public data sets of inspiration-expiration lung CT image pairs, which come with annotated corresponding landmarks for evaluation of the registration accuracy. Advantages of this methodology are its fast registration times and its minimal parameterization.

  5. Brand vs generic adverse event reporting patterns: An authorized generic-controlled evaluation of cardiovascular medications.

    Science.gov (United States)

    Alatawi, Y; Rahman, Md M; Cheng, N; Qian, J; Peissig, P L; Berg, R L; Page, C D; Hansen, R A

    2018-06-01

    Some public scepticism exists about generics in terms of whether brand and generic drugs produce identical outcomes. This study explores whether adverse event (AE) reporting patterns are similar between brand and generic drugs, using authorized generics (AGs) as a control for possible generic drug perception biases. Events reported to the FDA Adverse Event Reporting System from the years 2004-2015 were analysed. Drugs were classified as brand, AG or generic based on drug and manufacturer names. Reports were included if amlodipine, losartan, metoprolol extended release (ER) or simvastatin were listed as primary or secondary suspect drugs. Disproportionality analyses using the reporting odds ratio (ROR) assessed the relative rate of reporting labelled AEs compared to reporting these AEs with all other drugs. The Breslow-Day test compared RORs across brand, AG and generic. Interrupted time series analysis evaluated the impact of generic entry on reporting trends. Generics accounted for significant percentages of total U.S. reports, but AGs accounted for smaller percentages of reports, including for amlodipine (14.26%), losartan (1.48%), metoprolol ER (0.35%) and simvastatin (0.70%). Whereas the RORs were significantly different for multiple brand vs generic comparisons, the AG vs generic comparisons yielded fewer statistically significant findings. Namely, only the ROR for AG differed from generic for amlodipine with peripheral oedema (P brand and generic compared with AG and generic. Use of AGs as a control for perception biases against generics is useful, but this approach can be limited by small AG report numbers. Requiring the manufacturer name to be printed on the prescription bottle or packaging could improve the accuracy of assignment for products being reported. © 2017 John Wiley & Sons Ltd.

  6. Diffusion Maps for Multimodal Registration

    Directory of Open Access Journals (Sweden)

    Gemma Piella

    2014-06-01

    Full Text Available Multimodal image registration is a difficult task, due to the significant intensity variations between the images. A common approach is to use sophisticated similarity measures, such as mutual information, that are robust to those intensity variations. However, these similarity measures are computationally expensive and, moreover, often fail to capture the geometry and the associated dynamics linked with the images. Another approach is the transformation of the images into a common space where modalities can be directly compared. Within this approach, we propose to register multimodal images by using diffusion maps to describe the geometric and spectral properties of the data. Through diffusion maps, the multimodal data is transformed into a new set of canonical coordinates that reflect its geometry uniformly across modalities, so that meaningful correspondences can be established between them. Images in this new representation can then be registered using a simple Euclidean distance as a similarity measure. Registration accuracy was evaluated on both real and simulated brain images with known ground-truth for both rigid and non-rigid registration. Results showed that the proposed approach achieved higher accuracy than the conventional approach using mutual information.

  7. 76 FR 57060 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

    Science.gov (United States)

    2011-09-15

    ...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... veterinary use by the International Cooperation on Harmonisation of Technical Requirements for Registration... regulatory authorities and industry associations to promote the international harmonization of regulatory...

  8. 76 FR 57057 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

    Science.gov (United States)

    2011-09-15

    ...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... veterinary use by the International Cooperation on Harmonisation of Technical Requirements for Registration... undertaken by regulatory authorities and industry associations to promote the international harmonization of...

  9. Registration status and outcome reporting of trials published in core headache medicine journals.

    Science.gov (United States)

    Rayhill, Melissa L; Sharon, Roni; Burch, Rebecca; Loder, Elizabeth

    2015-11-17

    To evaluate randomized controlled trial (RCT) registration and outcome reporting compliance in core headache medicine journals. We identified RCTs published in core journals (Headache, Cephalalgia, and the Journal of Headache and Pain) from 2005 through 2014. We searched articles for trial registration numbers, which were verified in the corresponding trial registry. We categorized trial funding sources as industry, academic, government, or mixed. We contacted corresponding authors to assess reasons for nonregistration. We evaluated whether primary outcomes in trial registries matched those in corresponding publications. The journals published 225 RCTs over the study period. Fifty-eight of 225 (26%) reported a trial registration number in the article that could be linked to a corresponding registry entry. Trial registration rates increased over the 9 years of the study. Forty-six of 118 (39%) of industry-funded studies were registered compared with 27% of academic and 0% of government-funded studies. Only 5% of RCTs were prospectively registered, reported primary outcomes identical to those in the trial registry, and did not report unacknowledged post hoc outcomes. The most common reason for nonregistration was lack of awareness. Only about a quarter of the articles published in the core headache medicine journals are compliant with trial registration, but compliance has increased over time. Selective reporting of outcomes remains a problem, and very few trials met all 3 reporting standards assessed in this study. Efforts to improve the quality of trial reporting in the headache literature should continue. © 2015 American Academy of Neurology.

  10. Simultaneous 3D–2D image registration and C-arm calibration: Application to endovascular image-guided interventions

    Energy Technology Data Exchange (ETDEWEB)

    Mitrović, Uroš [Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, Ljubljana 1000, Slovenia and Cosylab, Control System Laboratory, Teslova ulica 30, Ljubljana 1000 (Slovenia); Pernuš, Franjo [Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, Ljubljana 1000 (Slovenia); Likar, Boštjan; Špiclin, Žiga, E-mail: ziga.spiclin@fe.uni-lj.si [Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, Ljubljana 1000, Slovenia and Sensum, Computer Vision Systems, Tehnološki Park 21, Ljubljana 1000 (Slovenia)

    2015-11-15

    Purpose: Three-dimensional to two-dimensional (3D–2D) image registration is a key to fusion and simultaneous visualization of valuable information contained in 3D pre-interventional and 2D intra-interventional images with the final goal of image guidance of a procedure. In this paper, the authors focus on 3D–2D image registration within the context of intracranial endovascular image-guided interventions (EIGIs), where the 3D and 2D images are generally acquired with the same C-arm system. The accuracy and robustness of any 3D–2D registration method, to be used in a clinical setting, is influenced by (1) the method itself, (2) uncertainty of initial pose of the 3D image from which registration starts, (3) uncertainty of C-arm’s geometry and pose, and (4) the number of 2D intra-interventional images used for registration, which is generally one and at most two. The study of these influences requires rigorous and objective validation of any 3D–2D registration method against a highly accurate reference or “gold standard” registration, performed on clinical image datasets acquired in the context of the intervention. Methods: The registration process is split into two sequential, i.e., initial and final, registration stages. The initial stage is either machine-based or template matching. The latter aims to reduce possibly large in-plane translation errors by matching a projection of the 3D vessel model and 2D image. In the final registration stage, four state-of-the-art intrinsic image-based 3D–2D registration methods, which involve simultaneous refinement of rigid-body and C-arm parameters, are evaluated. For objective validation, the authors acquired an image database of 15 patients undergoing cerebral EIGI, for which accurate gold standard registrations were established by fiducial marker coregistration. Results: Based on target registration error, the obtained success rates of 3D to a single 2D image registration after initial machine-based and

  11. Research Output of the Pakistani Library and Information Science Authors: A Bibliometric Evaluation of Their Impact

    Directory of Open Access Journals (Sweden)

    Anwar, Mumtaz Ali

    2017-06-01

    Full Text Available This paper uses 601 cited papers of Pakistani LIS researchers with the purpose to examine the individual performance of these Library and Information Science (LIS researchers in terms of their research output and its impact on the LIS (national/international literature by using various bibliometric indicators. A list of 139 authors was compiled with the help of the Library, Information Science, and Technology Abstracts (LISTA and some other sources. Data were collected from Google Scholar and SPSS version 20 was utilized in order to identify the relationship between self-citations and various performance indices of the authors. The average citations received per paper vary from 1.80 to 10.08. About half of the papers were single-authored whereas less than one-fifth were by three or more authors. The authors who worked in collaboration produced more papers and received more citations. The h-index, g-index, hI-index, hI-norm, and e-index were used to determine the rank for each author. The intra-group citations grid revealed the volume of self-citations and a small group who cite each other more due to close academic and social relationships. The correlations between self-citations and the impact indices used revealed significant differences. Findings are useful for concerned institutions regarding award, promotions, etc. Further, future research should seriously consider the self-citations and social networking of authors while examining their citations-based research performance.

  12. A high-accuracy image registration algorithm using phase-only correlation for dental radiographs

    International Nuclear Information System (INIS)

    Ito, Koichi; Nikaido, Akira; Aoki, Takafumi; Kosuge, Eiko; Kawamata, Ryota; Kashima, Isamu

    2008-01-01

    Dental radiographs have been used for the accurate assessment and treatment of dental diseases. The nonlinear deformation between two dental radiographs may be observed, even if they are taken from the same oral regions of the subject. For an accurate diagnosis, the complete geometric registration between radiographs is required. This paper presents an efficient dental radiograph registration algorithm using Phase-Only Correlation (POC) function. The use of phase components in 2D (two-dimensional) discrete Fourier transforms of dental radiograph images makes possible to achieve highly robust image registration and recognition. Experimental evaluation using a dental radiograph database indicates that the proposed algorithm exhibits efficient recognition performance even for distorted radiographs. (author)

  13. Evaluation Of The Advanced Operating System Of The Ann Arbor Transportation Authority : AATA Web Survey

    Science.gov (United States)

    1999-01-01

    During 1997, visitors to the Ann Arbor (Michigan) Transportation Authority's worldwide web site were invited to complete an electronic questionnaire about their experience with the site. Eighty surveys were collected, representing a non-scientific se...

  14. A Heuristic Evaluation of the Generalized Intelligent Framework for Tutoring (GIFT) Authoring Tools

    Science.gov (United States)

    2016-03-01

    incorporates the following: models of domain knowledge (e.g., content, feedback, and remediation); pedagogical methods based on best instructional practices... relationship to each other (i.e., an ontology). • User Control and Freedom: Users often choose system functions by mistake and will need a clearly marked...2.2.1 Issue: Name Mismatch between Gift Authoring Tool and Browser UI Users may not understand the relationship between the Gift Authoring Tool and

  15. SU-E-J-94: Geometric and Dosimetric Evaluation of Deformation Image Registration Algorithms Using Virtual Phantoms Generated From Patients with Lung Cancer

    International Nuclear Information System (INIS)

    Shen, Z; Greskovich, J; Xia, P; Bzdusek, K

    2015-01-01

    Purpose: To generate virtual phantoms with clinically relevant deformation and use them to objectively evaluate geometric and dosimetric uncertainties of deformable image registration (DIR) algorithms. Methods: Ten lung cancer patients undergoing adaptive 3DCRT planning were selected. For each patient, a pair of planning CT (pCT) and replanning CT (rCT) were used as the basis for virtual phantom generation. Manually adjusted meshes were created for selected ROIs (e.g. PTV, lungs, spinal cord, esophagus, and heart) on pCT and rCT. The mesh vertices were input into a thin-plate spline algorithm to generate a reference displacement vector field (DVF). The reference DVF was used to deform pCT to generate a simulated replanning CT (srCT) that was closely matched to rCT. Three DIR algorithms (Demons, B-Spline, and intensity-based) were applied to these ten virtual phantoms. The images, ROIs, and doses were mapped from pCT to srCT using the DVFs computed by these three DIRs and compared to those mapped using the reference DVF. Results: The average Dice coefficients for selected ROIs were from 0.85 to 0.96 for Demons, from 0.86 to 0.97 for intensity-based, and from 0.76 to 0.95 for B-Spline. The average Hausdorff distances for selected ROIs were from 2.2 to 5.4 mm for Demons, from 2.3 to 6.8 mm for intensity-based, and from 2.4 to 11.4 mm for B-Spline. The average absolute dose errors for selected ROIs were from 0.2 to 0.6 Gy for Demons, from 0.1 to 0.5 Gy for intensity-based, and from 0.5 to 1.5 Gy for B-Spline. Conclusion: Virtual phantoms were modeled after patients with lung cancer and were clinically relevant for adaptive radiotherapy treatment replanning. Virtual phantoms with known DVFs serve as references and can provide a fair comparison when evaluating different DIRs. Demons and intensity-based DIRs were shown to have smaller geometric and dosimetric uncertainties than B-Spline. Z Shen: None; K Bzdusek: an employee of Philips Healthcare; J Greskovich: None; P Xia

  16. SU-E-J-106: The Use of Deformable Image Registration with Cone-Beam CT for a Better Evaluation of Cumulative Dose to Organs

    Energy Technology Data Exchange (ETDEWEB)

    Fillion, O; Gingras, L; Archambault, L [Universite Laval, Quebec, Quebec (Canada); Centre de recherche du CHU de Quebec, Quebec, Quebec (Canada); Centre de recherche sur le cancer, Quebec, Quebec (Canada)

    2015-06-15

    Purpose: The knowledge of dose accumulation in the patient tissues in radiotherapy helps in determining the treatment outcomes. This project aims at providing a workflow to map cumulative doses that takes into account interfraction organ motion without the need for manual re-contouring. Methods: Five prostate cancer patients were studied. Each patient had a planning CT (pCT) and 5 to 13 CBCT scans. On each series, a physician contoured the prostate, rectum, bladder, seminal vesicles and the intestine. First, a deformable image registration (DIR) of the pCTs onto the daily CBCTs yielded registered CTs (rCT) . This rCT combined the accurate CT numbers of the pCT with the daily anatomy of the CBCT. Second, the original plans (220 cGy per fraction for 25 fractions) were copied on the rCT for dose re-calculation. Third, the DIR software Elastix was used to find the inverse transform from the rCT to the pCT. This transformation was then applied to the rCT dose grid to map the dose voxels back to their pCT location. Finally, the sum of these deformed dose grids for each patient was applied on the pCT to calculate the actual dose delivered to organs. Results: The discrepancy between the planned D98 and D2 and these indices re-calculated on the rCT, are, on average, of −1 ± 1 cGy and 1 ± 2 cGy per fraction, respectively. For fractions with large anatomical motion, the D98 discrepancy on the re-calculated dose grid mapped onto the pCT can raise to −17 ± 4 cGy. The obtained cumulative dose distributions illustrate the same behavior. Conclusion: This approach allowed the evaluation of cumulative doses to organs with the help of uncontoured daily CBCT scans. With this workflow, the easy evaluation of doses delivered for EBRT treatments could ultimately lead to a better follow-up of prostate cancer patients.

  17. SU-E-J-106: The Use of Deformable Image Registration with Cone-Beam CT for a Better Evaluation of Cumulative Dose to Organs

    International Nuclear Information System (INIS)

    Fillion, O; Gingras, L; Archambault, L

    2015-01-01

    Purpose: The knowledge of dose accumulation in the patient tissues in radiotherapy helps in determining the treatment outcomes. This project aims at providing a workflow to map cumulative doses that takes into account interfraction organ motion without the need for manual re-contouring. Methods: Five prostate cancer patients were studied. Each patient had a planning CT (pCT) and 5 to 13 CBCT scans. On each series, a physician contoured the prostate, rectum, bladder, seminal vesicles and the intestine. First, a deformable image registration (DIR) of the pCTs onto the daily CBCTs yielded registered CTs (rCT) . This rCT combined the accurate CT numbers of the pCT with the daily anatomy of the CBCT. Second, the original plans (220 cGy per fraction for 25 fractions) were copied on the rCT for dose re-calculation. Third, the DIR software Elastix was used to find the inverse transform from the rCT to the pCT. This transformation was then applied to the rCT dose grid to map the dose voxels back to their pCT location. Finally, the sum of these deformed dose grids for each patient was applied on the pCT to calculate the actual dose delivered to organs. Results: The discrepancy between the planned D98 and D2 and these indices re-calculated on the rCT, are, on average, of −1 ± 1 cGy and 1 ± 2 cGy per fraction, respectively. For fractions with large anatomical motion, the D98 discrepancy on the re-calculated dose grid mapped onto the pCT can raise to −17 ± 4 cGy. The obtained cumulative dose distributions illustrate the same behavior. Conclusion: This approach allowed the evaluation of cumulative doses to organs with the help of uncontoured daily CBCT scans. With this workflow, the easy evaluation of doses delivered for EBRT treatments could ultimately lead to a better follow-up of prostate cancer patients

  18. Phantom study and accuracy evaluation of an image-to-world registration approach used with electro-magnetic tracking system for neurosurgery

    Science.gov (United States)

    Li, Senhu; Sarment, David

    2015-12-01

    Minimally invasive neurosurgery needs intraoperative imaging updates and high efficient image guide system to facilitate the procedure. An automatic image guided system utilized with a compact and mobile intraoperative CT imager was introduced in this work. A tracking frame that can be easily attached onto the commercially available skull clamp was designed. With known geometry of fiducial and tracking sensor arranged on this rigid frame that was fabricated through high precision 3D printing, not only was an accurate, fully automatic registration method developed in a simple and less-costly approach, but also it helped in estimating the errors from fiducial localization in image space through image processing, and in patient space through the calibration of tracking frame. Our phantom study shows the fiducial registration error as 0.348+/-0.028mm, comparing the manual registration error as 1.976+/-0.778mm. The system in this study provided a robust and accurate image-to-patient registration without interruption of routine surgical workflow and any user interactions involved through the neurosurgery.

  19. An automatic MRI/SPECT registration algorithm using image intensity and anatomical feature as matching characters: application on the evaluation of Parkinson's disease

    International Nuclear Information System (INIS)

    Lee, J.-D.; Huang, C.-H.; Weng, Y.-H.; Lin, K.-J.; Chen, C.-T.

    2007-01-01

    Single-photon emission computed tomography (SPECT) of dopamine transporters with 99m Tc-TRODAT-1 has recently been proposed to offer valuable information in assessing the functionality of dopaminergic systems. Magnetic resonance imaging (MRI) and SPECT imaging are important in the noninvasive examination of dopamine concentration in vivo. Therefore, this investigation presents an automated MRI/SPECT image registration algorithm based on a new similarity metric. This similarity metric combines anatomical features that are characterized by specific binding, the mean count per voxel in putamens and caudate nuclei, and the distribution of image intensity that is characterized by normalized mutual information (NMI). A preprocess, a novel two-cluster SPECT normalization algorithm, is also presented for MRI/SPECT registration. Clinical MRI/SPECT data from 18 healthy subjects and 13 Parkinson's disease (PD) patients are involved to validate the performance of the proposed algorithms. An appropriate color map, such as 'rainbow,' for image display enables the two-cluster SPECT normalization algorithm to provide clinically meaningful visual contrast. The proposed registration scheme reduces target registration error from >7 mm for conventional registration algorithm based on NMI to approximately 4 mm. The error in the specific/nonspecific 99m Tc-TRODAT-1 binding ratio, which is employed as a quantitative measure of TRODAT receptor binding, is also reduced from 0.45±0.22 to 0.08±0.06 among healthy subjects and from 0.28±0.18 to 0.12±0.09 among PD patients

  20. Author Details

    African Journals Online (AJOL)

    Journal Home > Advanced Search > Author Details. Log in or Register ... (2013) - Articles Technical Note: Development of a Photobioreactor for Microalgae Culture ... Design, Construction and Evaluation of Motorized Okra Slicer Abstract PDF ...

  1. Author Details

    African Journals Online (AJOL)

    Journal Home > Advanced Search > Author Details. Log in or ... The prevention of mother-to-child HIV transmission programme and infant feeding practices ... Evaluation of a diagnostic algorithm for smear-negative pulmonary tuberculosis in ...

  2. Metrics for evaluation of the author's writing styles: who is the best?

    Science.gov (United States)

    Darooneh, Amir H; Shariati, Ashrafosadat

    2014-09-01

    Studying the complexity of language has attracted the physicist's attention recently. The methods borrowed from the statistical mechanics; namely, the complex network theory, can be used for exploring the regularities as a characteristic of complexity of language. In this paper, we focus on the authorship identification by using the complex network approach. We introduce three metrics which enable us for comparison the author's writing styles. This approach was previously used by us for finding the author of unknown book among collection of thirty six books written by five Persian poets. Here, we select a collection of one hundred and one books of nine English writers and quantify their writing styles according to our metrics. In our experiment, Shakespeare appears as the best author who follows a unique writing style in all of his works.

  3. Metrics for evaluation of the author's writing styles: Who is the best?

    Science.gov (United States)

    Darooneh, Amir H.; Shariati, Ashrafosadat

    2014-09-01

    Studying the complexity of language has attracted the physicist's attention recently. The methods borrowed from the statistical mechanics; namely, the complex network theory, can be used for exploring the regularities as a characteristic of complexity of language. In this paper, we focus on the authorship identification by using the complex network approach. We introduce three metrics which enable us for comparison the author's writing styles. This approach was previously used by us for finding the author of unknown book among collection of thirty six books written by five Persian poets. Here, we select a collection of one hundred and one books of nine English writers and quantify their writing styles according to our metrics. In our experiment, Shakespeare appears as the best author who follows a unique writing style in all of his works.

  4. Assessing and Evaluating Ḥadith: Its Value, Significance, Authority and Authenticity in Islamic Thought

    Directory of Open Access Journals (Sweden)

    Dr. Farhat Nisar

    2017-07-01

    Full Text Available Qur’an and Ḥadith as fundamental and primary sources of Shariah stand as hall mark of Islam. Ḥadith called traditions as the second fundamental source of Islam embodies sayings, actions and expressions of Prophet Muhammad (SAW explicit or implicit. Mainly there have been two trends of rejecting the status of Ḥadith. One is rejecting the authority of Ḥadith and other rejects the authenticity of Ḥadith especially “Khabar-al-wahid” or solitary tradition. Other group does not completely reject the authority of Ḥadith rather text of Ḥadith especially in case of weak traditions. This paper discuss the opinion of rejecters of Ḥadith and contribution of Muslim scholars along with their arguments from Qur’an and Sunnah of Prophet Muhammad (SAW to highlight the importance and significance of authority and authenticity of Ḥadith in all disciplines of Islamic thought.

  5. Author Guidelines

    Directory of Open Access Journals (Sweden)

    Chief Editor

    2015-12-01

    they help authors describe the study in enough detail for it to be evaluated by editors, reviewers, readers, and other researchers evaluating the medical literature. Authors of review manuscripts are encouraged to describe the methods used for locating, select¬ing, extracting, and synthesizing data; this is mandatory for systematic reviews. Good sources for reporting guidelines are the EQUATOR Network and the NLM's Research Reporting Guidelines and Initiatives.3. Manuscript SectionsThe following are general requirements for reporting within sections of all study designs and manuscript formats.a. Title PageGeneral information about an article and its authors is presented on a manuscript title page and usually includes the article title, author information, any disclaimers, sources of support, word count, and sometimes the number of tables and figures.Article title. The title provides a distilled description of the complete article and should include information that, along with the Abstract, will make electronic retrieval of the article sensitive and specific. Reporting guidelines recommend and some journals require that information about the study design be a part of the title (particularly important for randomized trials and systematic reviews and meta-analyses. Some journals require a short title, usually no more than 40 characters (including letters and spaces on the title page or as a separate entry in an electronic submission system. Electronic submission systems may restrict the number of characters in the title. Author information: Each author's highest academic degrees should be listed, although some journals do not publish these. The name of the department(s and institution(s or organizations where the work should be attributed should be specified. Most electronic submission systems require that authors provide full contact information, including land mail and e-mail addresses, but the title page should list the corresponding authors' telephone and fax

  6. Phase III (final) evaluation report : national evaluation of the FY01 earmark, area transportation authority of North Central Pennsylvania--regional GIS/ITS initiative.

    Science.gov (United States)

    2009-08-31

    This report presents the results of the United States Department of Transportation evaluation of a federally funded earmark project implemented by the Area Transportation Authority of North Central Pennsylvania (ATA). The project implemented a suite ...

  7. SU-E-J-119: Head-And-Neck Digital Phantoms for Geometric and Dosimetric Uncertainty Evaluation of CT-CBCT Deformable Image Registration

    International Nuclear Information System (INIS)

    Shen, Z; Koyfman, S; Xia, P; Bzdusek, K

    2015-01-01

    Purpose: To evaluate geometric and dosimetric uncertainties of CT-CBCT deformable image registration (DIR) algorithms using digital phantoms generated from real patients. Methods: We selected ten H&N cancer patients with adaptive IMRT. For each patient, a planning CT (CT1), a replanning CT (CT2), and a pretreatment CBCT (CBCT1) were used as the basis for digital phantom creation. Manually adjusted meshes were created for selected ROIs (e.g. PTVs, brainstem, spinal cord, mandible, and parotids) on CT1 and CT2. The mesh vertices were input into a thin-plate spline algorithm to generate a reference displacement vector field (DVF). The reference DVF was applied to CBCT1 to create a simulated mid-treatment CBCT (CBCT2). The CT-CBCT digital phantom consisted of CT1 and CBCT2, which were linked by the reference DVF. Three DIR algorithms (Demons, B-Spline, and intensity-based) were applied to these ten digital phantoms. The images, ROIs, and volumetric doses were mapped from CT1 to CBCT2 using the DVFs computed by these three DIRs and compared to those mapped using the reference DVF. Results: The average Dice coefficients for selected ROIs were from 0.83 to 0.94 for Demons, from 0.82 to 0.95 for B-Spline, and from 0.67 to 0.89 for intensity-based DIR. The average Hausdorff distances for selected ROIs were from 2.4 to 6.2 mm for Demons, from 1.8 to 5.9 mm for B-Spline, and from 2.8 to 11.2 mm for intensity-based DIR. The average absolute dose errors for selected ROIs were from 0.7 to 2.1 Gy for Demons, from 0.7 to 2.9 Gy for B- Spline, and from 1.3 to 4.5 Gy for intensity-based DIR. Conclusion: Using clinically realistic CT-CBCT digital phantoms, Demons and B-Spline were shown to have similar geometric and dosimetric uncertainties while intensity-based DIR had the worst uncertainties. CT-CBCT DIR has the potential to provide accurate CBCT-based dose verification for H&N adaptive radiotherapy. Z Shen: None; K Bzdusek: an employee of Philips Healthcare; S Koyfman: None; P Xia

  8. MO-C-17A-02: A Novel Method for Evaluating Hepatic Stiffness Based On 4D-MRI and Deformable Image Registration

    Energy Technology Data Exchange (ETDEWEB)

    Cui, T [Duke University, Durham, NC (United States); Liang, X [Duke Unversity, Durham, NC (United States); Czito, B; Palta, M; Bashir, M; Yin, F; Cai, J [Duke University Medical Center, Durham, NC (United States)

    2014-06-15

    Purpose: Quantitative imaging of hepatic stiffness has significant potential in radiation therapy, ranging from treatment planning to response assessment. This study aims to develop a novel, noninvasive method to quantify liver stiffness with 3D strains liver maps using 4D-MRI and deformable image registration (DIR). Methods: Five patients with liver cancer were imaged with an institutionally developed 4D-MRI technique under an IRB-approved protocol. Displacement vector fields (DVFs) across the liver were generated via DIR of different phases of 4D-MRI. Strain tensor at each voxel of interest (VOI) was computed from the relative displacements between the VOI and each of the six adjacent voxels. Three principal strains (E{sub 1}, E{sub 2} and E{sub 3}) of the VOI were derived as the eigenvalue of the strain tensor, which represent the magnitudes of the maximum and minimum stretches. Strain tensors for two regions of interest (ROIs) were calculated and compared for each patient, one within the tumor (ROI{sub 1}) and the other in normal liver distant from the heart (ROI{sub 2}). Results: 3D strain maps were successfully generated fort each respiratory phase of 4D-MRI for all patients. Liver deformations induced by both respiration and cardiac motion were observed. Differences in strain values adjacent to the distant from the heart indicate significant deformation caused by cardiac expansion during diastole. The large E{sub 1}/E{sub 2} (∼2) and E{sub 1}/E{sub 2} (∼10) ratios reflect the predominance of liver deformation in the superior-inferior direction. The mean E{sub 1} in ROI{sub 1} (0.12±0.10) was smaller than in ROI{sub 2} (0.15±0.12), reflecting a higher degree of stiffness of the cirrhotic tumor. Conclusion: We have successfully developed a novel method for quantitatively evaluating regional hepatic stiffness based on DIR of 4D-MRI. Our initial findings indicate that liver strain is heterogeneous, and liver tumors may have lower principal strain values

  9. MO-C-17A-02: A Novel Method for Evaluating Hepatic Stiffness Based On 4D-MRI and Deformable Image Registration

    International Nuclear Information System (INIS)

    Cui, T; Liang, X; Czito, B; Palta, M; Bashir, M; Yin, F; Cai, J

    2014-01-01

    Purpose: Quantitative imaging of hepatic stiffness has significant potential in radiation therapy, ranging from treatment planning to response assessment. This study aims to develop a novel, noninvasive method to quantify liver stiffness with 3D strains liver maps using 4D-MRI and deformable image registration (DIR). Methods: Five patients with liver cancer were imaged with an institutionally developed 4D-MRI technique under an IRB-approved protocol. Displacement vector fields (DVFs) across the liver were generated via DIR of different phases of 4D-MRI. Strain tensor at each voxel of interest (VOI) was computed from the relative displacements between the VOI and each of the six adjacent voxels. Three principal strains (E 1 , E 2 and E 3 ) of the VOI were derived as the eigenvalue of the strain tensor, which represent the magnitudes of the maximum and minimum stretches. Strain tensors for two regions of interest (ROIs) were calculated and compared for each patient, one within the tumor (ROI 1 ) and the other in normal liver distant from the heart (ROI 2 ). Results: 3D strain maps were successfully generated fort each respiratory phase of 4D-MRI for all patients. Liver deformations induced by both respiration and cardiac motion were observed. Differences in strain values adjacent to the distant from the heart indicate significant deformation caused by cardiac expansion during diastole. The large E 1 /E 2 (∼2) and E 1 /E 2 (∼10) ratios reflect the predominance of liver deformation in the superior-inferior direction. The mean E 1 in ROI 1 (0.12±0.10) was smaller than in ROI 2 (0.15±0.12), reflecting a higher degree of stiffness of the cirrhotic tumor. Conclusion: We have successfully developed a novel method for quantitatively evaluating regional hepatic stiffness based on DIR of 4D-MRI. Our initial findings indicate that liver strain is heterogeneous, and liver tumors may have lower principal strain values than normal liver. Thorough validation of our method is

  10. Registration of Laser Scanning Point Clouds: A Review

    Science.gov (United States)

    Cheng, Liang; Chen, Song; Xu, Hao; Wu, Yang; Li, Manchun

    2018-01-01

    The integration of multi-platform, multi-angle, and multi-temporal LiDAR data has become important for geospatial data applications. This paper presents a comprehensive review of LiDAR data registration in the fields of photogrammetry and remote sensing. At present, a coarse-to-fine registration strategy is commonly used for LiDAR point clouds registration. The coarse registration method is first used to achieve a good initial position, based on which registration is then refined utilizing the fine registration method. According to the coarse-to-fine framework, this paper reviews current registration methods and their methodologies, and identifies important differences between them. The lack of standard data and unified evaluation systems is identified as a factor limiting objective comparison of different methods. The paper also describes the most commonly-used point cloud registration error analysis methods. Finally, avenues for future work on LiDAR data registration in terms of applications, data, and technology are discussed. In particular, there is a need to address registration of multi-angle and multi-scale data from various newly available types of LiDAR hardware, which will play an important role in diverse applications such as forest resource surveys, urban energy use, cultural heritage protection, and unmanned vehicles.

  11. Biomedical Image Registration

    DEFF Research Database (Denmark)

    This book constitutes the refereed proceedings of the 8th International Workshop on Biomedical Image Registration, WBIR 2018, held in Leiden, The Netherlands, in June 2018. The 11 full and poster papers included in this volume were carefully reviewed and selected from 17 submitted papers. The pap...

  12. Locally orderless registration

    DEFF Research Database (Denmark)

    Darkner, Sune; Sporring, Jon

    2013-01-01

    This paper presents a unifying approach for calculating a wide range of popular, but seemingly very different, similarity measures. Our domain is the registration of n-dimensional images sampled on a regular grid, and our approach is well suited for gradient-based optimization algorithms. Our app...

  13. Registration of Plant Varieties

    African Journals Online (AJOL)

    Registration of two Sorghum Hybrids, ESH-1 and ESH-2. Sorghum (Sorghum bicolor (L) Moench) is an indigenous crop to Ethiopia and staple for many millions of people in most parts of Africa. The crop is one of the most important cereals grown in arid and semi arid areas where others often fail to survive. In Eastern Africa ...

  14. An Evaluation of the Generalized Intelligent Framework for Tutoring (GIFT) from an Author’s Perspective

    Science.gov (United States)

    2014-12-01

    An Evaluation of the Generalized Intelligent Framework for Tutoring (GIFT) from an Author’s Perspective by Robert A Sottilare, Keith W...Intelligent Framework for Tutoring (GIFT) from an Author’s Perspective Robert A Sottilare and Keith W Brawner Human Research and Engineering...SUBTITLE An Evaluation of the Generalized Intelligent Framework for Tutoring (GIFT) from an Author’s Perspective 5a. CONTRACT NUMBER 5b. GRANT

  15. A Bayesian nonrigid registration method to enhance intraoperative target definition in image-guided prostate procedures through uncertainty characterization

    International Nuclear Information System (INIS)

    Pursley, Jennifer; Risholm, Petter; Fedorov, Andriy; Tuncali, Kemal; Fennessy, Fiona M.; Wells, William M. III; Tempany, Clare M.; Cormack, Robert A.

    2012-01-01

    Purpose: This study introduces a probabilistic nonrigid registration method for use in image-guided prostate brachytherapy. Intraoperative imaging for prostate procedures, usually transrectal ultrasound (TRUS), is typically inferior to diagnostic-quality imaging of the pelvis such as endorectal magnetic resonance imaging (MRI). MR images contain superior detail of the prostate boundaries and provide substructure features not otherwise visible. Previous efforts to register diagnostic prostate images with the intraoperative coordinate system have been deterministic and did not offer a measure of the registration uncertainty. The authors developed a Bayesian registration method to estimate the posterior distribution on deformations and provide a case-specific measure of the associated registration uncertainty. Methods: The authors adapted a biomechanical-based probabilistic nonrigid method to register diagnostic to intraoperative images by aligning a physician's segmentations of the prostate in the two images. The posterior distribution was characterized with a Markov Chain Monte Carlo method; the maximum a posteriori deformation and the associated uncertainty were estimated from the collection of deformation samples drawn from the posterior distribution. The authors validated the registration method using a dataset created from ten patients with MRI-guided prostate biopsies who had both diagnostic and intraprocedural 3 Tesla MRI scans. The accuracy and precision of the estimated posterior distribution on deformations were evaluated from two predictive distance distributions: between the deformed central zone-peripheral zone (CZ-PZ) interface and the physician-labeled interface, and based on physician-defined landmarks. Geometric margins on the registration of the prostate's peripheral zone were determined from the posterior predictive distance to the CZ-PZ interface separately for the base, mid-gland, and apical regions of the prostate. Results: The authors observed

  16. Improvement of Measurement and Evaluation of Regional Authorities Activity: Model and Statistical Approach

    Directory of Open Access Journals (Sweden)

    Petrova Elena Аleksandrovna

    2014-11-01

    Full Text Available Formation of strategy of long-term social and economic development is a basis for effective functioning of executive authorities and the assessment of its efficiency in general. Modern theories of assessment of public administration productivity are guided by the process approach when it is expedient to carry out the formation of business processes of regional executive authorities according to strategic indicators of territorial development. In this regard, there is a problem of modeling of interrelation of indicators of social and economic development of the region and quantitative indices of results of business processes of executive authorities. At the first stage of modeling, two main directions of strategic development, namely innovative and investment activity of regional economic systems are considered. In this regard, the work presents the results of modeling the interrelation between the indicators of regional social and economic development and innovative and investment activity. Therefore, for carrying out the analysis, the social and economic system of the region is presented in space of the main indicators of social and economic development of the territory and indicators of innovative and investment activity. The analysis is made on values of the indicators calculated for regions of the Russian Federation during 2000, 2005, 2008, 2010 and 2011. It was revealed that strategic indicators of innovative and investment activity have the most significant impact on key signs of social and economic development.

  17. Author Details

    African Journals Online (AJOL)

    Akdeniz, G. Vol 10, No 2 (2013) - Articles RAPD-PCR and real-time Pcr Hrm based genetic variation evaluations of Urtica dioica parts, ecotypes and evaluations of morphotypes in Turkey Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

  18. Registration of 3-dimensional facial photographs for clinical use.

    Science.gov (United States)

    Maal, Thomas J J; van Loon, Bram; Plooij, Joanneke M; Rangel, Frits; Ettema, Anke M; Borstlap, Wilfred A; Bergé, Stefaan J

    2010-10-01

    To objectively evaluate treatment outcomes in oral and maxillofacial surgery, pre- and post-treatment 3-dimensional (3D) photographs of the patient's face can be registered. For clinical use, it is of great importance that this registration process is accurate (photographs were captured at 3 different times: baseline (T(0)), after 1 minute (T(1)), and 3 weeks later (T(2)). Furthermore, a 3D photograph of the volunteer laughing (T(L)) was acquired to investigate the effect of facial expression. Two different registration methods were used to register the photographs acquired at all different times: surface-based registration and reference-based registration. Within the surface-based registration, 2 different software packages (Maxilim [Medicim NV, Mechelen, Belgium] and 3dMD Patient [3dMD LLC, Atlanta, GA]) were used to register the 3D photographs acquired at the various times. The surface-based registration process was repeated with the preprocessed photographs. Reference-based registration (Maxilim) was performed twice by 2 observers investigating the inter- and intraobserver error. The mean registration errors are small for the 3D photographs at rest (0.39 mm for T(0)-T(1) and 0.52 mm for T(0)-T(2)). The mean registration error increased to 1.2 mm for the registration between the 3D photographs acquired at T(0) and T(L). The mean registration error for the reference-based method was 1.0 mm for T(0)-T(1), 1.1 mm for T(0)-T(2), and 1.5 mm for T(0) and T(L). The mean registration errors for the preprocessed photographs were even smaller (0.30 mm for T(0)-T(1), 0.42 mm for T(0)-T(2), and 1.2 mm for T(0) and T(L)). Furthermore, a strong correlation between the results of both software packages used for surface-based registration was found. The intra- and interobserver error for the reference-based registration method was found to be 1.2 and 1.0 mm, respectively. Surface-based registration is an accurate method to compare 3D photographs of the same individual at

  19. Accelerating Neuroimage Registration through Parallel Computation of Similarity Metric.

    Directory of Open Access Journals (Sweden)

    Yun-Gang Luo

    Full Text Available Neuroimage registration is crucial for brain morphometric analysis and treatment efficacy evaluation. However, existing advanced registration algorithms such as FLIRT and ANTs are not efficient enough for clinical use. In this paper, a GPU implementation of FLIRT with the correlation ratio (CR as the similarity metric and a GPU accelerated correlation coefficient (CC calculation for the symmetric diffeomorphic registration of ANTs have been developed. The comparison with their corresponding original tools shows that our accelerated algorithms can greatly outperform the original algorithm in terms of computational efficiency. This paper demonstrates the great potential of applying these registration tools in clinical applications.

  20. The hidden KPI registration accuracy.

    Science.gov (United States)

    Shorrosh, Paul

    2011-09-01

    Determining the registration accuracy rate is fundamental to improving revenue cycle key performance indicators. A registration quality assurance (QA) process allows errors to be corrected before bills are sent and helps registrars learn from their mistakes. Tools are available to help patient access staff who perform registration QA manually.

  1. Personal protective equipment for registration purposes of pesticides

    NARCIS (Netherlands)

    Gerritsen-Ebben, M.G.; Brouwer, D.H.; Hemmen, J.J. van

    2007-01-01

    Regulatory authorities in North America, Europe and Australia use different approaches for the estimation of exposure reduction effectiveness of personal protective equipment (PPE) in registration processes of agrochemical pesticides. TNO has investigated current views and facts for the use of

  2. Evaluation of Super Voxel Methods for Early Video Processing (Author’s Manuscript)

    Science.gov (United States)

    2012-07-26

    supervoxels in space- time [22]. This property embodies many of the basic Gestalt principles—proximity, continuation, closure, and symmetry—and helps...streaming approach. The mean shift algorithm used in our paper is presented by Paris and Durand [29], who introduce Morse theory to interpret mean...maximum 86 fpv. This data set allows us to evaluate the supervoxel methods against human perception . The third data set is from Grundman et al. [15

  3. Department of Defense and Security Cooperation: Improving Prioritization, Authorities, and Evaluations

    Science.gov (United States)

    2016-03-09

    March 9, 2016 Chairman Fischer , Ranking Member Nelson, and distinguished members of the subcommittee, thank you for the opportunity to testify...on the important subject of U.S. security cooperation. It’s a pleasure to appear before you today along with my colleagues, Jeff Eggers and Melissa...based evaluations. Chairman Fischer , Ranking Member Nelson, and members of the subcommittee, I appreciate the opportunity to offer this testimony, and I look forward to assisting the committee in its vital work.

  4. 18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy.

    Science.gov (United States)

    Ding, Yao; Zhu, Yuankai; Jiang, Biao; Zhou, Yongji; Jin, Bo; Hou, Haifeng; Wu, Shuang; Zhu, Junming; Wang, Zhong Irene; Wong, Chong H; Ding, Meiping; Zhang, Hong; Wang, Shuang; Tian, Mei

    2018-04-18

    Epilepsy that originates outside of the temporal lobe can present some of the most challenging problems for surgical therapy, especially for patients with conventional magnetic resonance imaging (MRI)-negative refractory extra-temporal lobe epilepsy (ETLE). This study aimed to evaluate the clinical value of pre-surgical 18 F-fluoro-deoxy-glucose positron emission tomography ( 18 F-FDG PET) and high-resolution MRI (HR-MRI) co-registration in patients with conventional MRI-negative refractory ETLE, and compare their surgical outcomes. Sixty-seven patients with conventional MRI-negative refractory ETLE were prospectively included for pre-surgical 18 F-FDG PET and HR-MRI examinations. Under the guidance of 18 F-FDG PET and HR-MRI co-registration, HR-MRI images were re-read. Based on the image result changes from first reading to re-reading, patients were divided into three groups: Change-1 (lesions of subtle abnormality could be identified in re-read), Change-2 (non-specific abnormalities reported in the first reading were considered as lesions on HR-MRI re-read) and No-change. Post-surgical follow-ups were conducted for up to 59 months. Visual analysis of 18 F-FDG PET showed focal or regional abnormality in 46 patients (68.6%), while the abnormal rate increased to 94.0% (P evaluation by co-registration of 18 F-FDG PET and HR-MRI could improve the identification of the epileptogenic onset zone (EOZ), and may further guide the surgical decision-making and improve the outcome of the refractory ETLE with normal conventional MRI; therefore, it should be recommended as a standard procedure for pre-surgical evaluation of these patients.

  5. Registration of acute stroke

    DEFF Research Database (Denmark)

    Wildenschild, Cathrine; Mehnert, Frank; Thomsen, Reimar Wernich

    2014-01-01

    BACKGROUND: The validity of the registration of patients in stroke-specific registries has seldom been investigated, nor compared with administrative hospital discharge registries. The objective of this study was to examine the validity of the registration of patients in a stroke-specific registry...... (The Danish Stroke Registry [DSR]) and a hospital discharge registry (The Danish National Patient Registry [DNRP]). METHODS: Assuming that all patients with stroke were registered in either the DSR, DNRP or both, we first identified a sample of 75 patients registered with stroke in 2009; 25 patients...... in the DSR, 25 patients in the DNRP, and 25 patients registered in both data sources. Using the medical record as a gold standard, we then estimated the sensitivity and positive predictive value of a stroke diagnosis in the DSR and the DNRP. Secondly, we reviewed 160 medical records for all potential stroke...

  6. [Materno-fetal acid-base equilibrium evaluation in parturients submitted to ketamine anesthesia (author's transl)].

    Science.gov (United States)

    Mauad Filho, F; Meirelles, R S

    1975-01-01

    In the present work ketamine was used as anesthetic during the labor in order to evaluate the effect of this anesthetic on the binominal fetus-mother. Two groups of parturients and their fetuses, were studied: 1) The experimental group, with 22 parturients and their fetuses submitted to ketamine anesthesia during the labord, and 2) The control group, with 20 parturients and their fetuses without any analgesic treatment during the labor. In 20 cases of the experimental group the anesthetic was injected during the delivery labor and the other two just before it. It were evaluated in the mother's blood the biochemical parameters of the acid-base balance and others collateral effects of the anesthesia; on the fetus's side the same parameters also and the cardiac frequency. The newborn were evaluated by Apgar Score during the first and fifth minutes of life. The incidence of the spontaneous delivery in the experimental group, was 78%; in 22% of these patients the forceps of relief was used. In 22 cases in which Ketamine was applied it were observed, the following events: elevation of the blood pressure (50%), perineum rigidness (18%), dreams and or hallucinations (18%), increase of the cardiac frequency (9%), apneia (4%) and nausea (4%). It was also observed an increase of uterine tonus an abolishment of abdominal press during the delivery labor, studied through the uterine electromyography register. It was noted after the Ketamine application a fall in the pH of the maternal peripherical venous blood, fetal skull blood and the pH of the blood of the umbilical vein. 22% of the newborns, from the experimental group, presented a depression in the first minute of life (Apgar less than or equals to 6). The pCO2 values in the blood of the umbilical artery were higher in the experimental group than in the control one.

  7. [Evaluating programs for preparation to old age: some theoretical thoughts and a practical example (author's transl)].

    Science.gov (United States)

    Schneider, H D

    1977-07-01

    In the first part methodically satisfactory experimental designs for evaluating programs for preparation to old age on the basis of Cambell & Stanely (1963) are sketched including conditions which hinder the realization of the ideal notions. In the second part an experiment for comparing two preparatory courses to old age using different methods of instruction is described. It was observed that the more demanding teaching method resulted in more anxiety for old age. This led to the conclusion, that programs for preparation to old age should be planned as a sequence of several units in which the mastering of the new ideas may be learned and in which this learning process may be supervised.

  8. Image registration with uncertainty analysis

    Science.gov (United States)

    Simonson, Katherine M [Cedar Crest, NM

    2011-03-22

    In an image registration method, edges are detected in a first image and a second image. A percentage of edge pixels in a subset of the second image that are also edges in the first image shifted by a translation is calculated. A best registration point is calculated based on a maximum percentage of edges matched. In a predefined search region, all registration points other than the best registration point are identified that are not significantly worse than the best registration point according to a predetermined statistical criterion.

  9. A multicore based parallel image registration method.

    Science.gov (United States)

    Yang, Lin; Gong, Leiguang; Zhang, Hong; Nosher, John L; Foran, David J

    2009-01-01

    Image registration is a crucial step for many image-assisted clinical applications such as surgery planning and treatment evaluation. In this paper we proposed a landmark based nonlinear image registration algorithm for matching 2D image pairs. The algorithm was shown to be effective and robust under conditions of large deformations. In landmark based registration, the most important step is establishing the correspondence among the selected landmark points. This usually requires an extensive search which is often computationally expensive. We introduced a nonregular data partition algorithm using the K-means clustering algorithm to group the landmarks based on the number of available processing cores. The step optimizes the memory usage and data transfer. We have tested our method using IBM Cell Broadband Engine (Cell/B.E.) platform.

  10. Evaluation of a medication order writing standards policy in a regional health authority

    Science.gov (United States)

    Raymond, Colette B.; Coates, Jan; Woloschuk, Donna M. M.

    2013-01-01

    Background: The Winnipeg Regional Health Authority (WRHA) implemented a medication order writing standards (MOWS) policy (including banned abbreviations) to improve patient safety. Widespread educational campaigns and direct prescriber feedback were implemented. Methods: We audited orders within the WRHA from 2005 to 2009 and surveyed all WRHA staff in 2011 about the policy and suggestions for improving education and compliance. Results: Overall, orders containing banned abbreviations, acronyms or symbols numbered 2261/8565 (26.4%) preimplementation. After WRHA-wide didactic education, the proportion declined to 1358/5461 (24.9%) (p = 0.043) and then, with targeted prescriber feedback, to 1186/6198 (19.1%) (p < 0.0001). A survey of 723 employees showed frequent violations of the MOWS, despite widespread knowledge of the policy. Respondents supported ongoing efforts to enforce the policy within the WRHA. Nonprescribers were significantly more likely than prescribers to agree with statements regarding enhancing compliance by defining prescriber/transcriber responsibilities and placing sanctions on noncompliant prescribers. Discussion: Education, raising general awareness and targeted feedback to prescribers alone are insufficient to ensure compliance with MOWS policies. WRHA staff supported ongoing communication, improved tools such as compliant preprinted orders and reporting and feedback about medication incidents. A surprising number of respondents supported placing sanctions on noncompliant prescribers. Conclusion: Serial audits and targeted interventions such as direct prescriber feedback improve prescription quality in inpatient hospital settings. Education plus direct prescriber feedback had a greater impact than education alone on improving compliance with a MOWS policy. Future efforts at the WRHA to improve compliance will require an expanded focus on incentives, resources and development of action plans that involve all affected staff, not just prescribers

  11. Surface-based prostate registration with biomechanical regularization

    Science.gov (United States)

    van de Ven, Wendy J. M.; Hu, Yipeng; Barentsz, Jelle O.; Karssemeijer, Nico; Barratt, Dean; Huisman, Henkjan J.

    2013-03-01

    Adding MR-derived information to standard transrectal ultrasound (TRUS) images for guiding prostate biopsy is of substantial clinical interest. A tumor visible on MR images can be projected on ultrasound by using MRUS registration. A common approach is to use surface-based registration. We hypothesize that biomechanical modeling will better control deformation inside the prostate than a regular surface-based registration method. We developed a novel method by extending a surface-based registration with finite element (FE) simulation to better predict internal deformation of the prostate. For each of six patients, a tetrahedral mesh was constructed from the manual prostate segmentation. Next, the internal prostate deformation was simulated using the derived radial surface displacement as boundary condition. The deformation field within the gland was calculated using the predicted FE node displacements and thin-plate spline interpolation. We tested our method on MR guided MR biopsy imaging data, as landmarks can easily be identified on MR images. For evaluation of the registration accuracy we used 45 anatomical landmarks located in all regions of the prostate. Our results show that the median target registration error of a surface-based registration with biomechanical regularization is 1.88 mm, which is significantly different from 2.61 mm without biomechanical regularization. We can conclude that biomechanical FE modeling has the potential to improve the accuracy of multimodal prostate registration when comparing it to regular surface-based registration.

  12. Laser interrogation of latent vehicle registration number

    Energy Technology Data Exchange (ETDEWEB)

    Russo, R.E. [Lawrence Berkeley Lab., CA (United States). Energy and Environment Div.]|[Lawrence Livermore National Lab., CA (United States). Forensic Science Center; Pelkey, G.E. [City of Livermore Police Dept., CA (United States); Grant, P.; Whipple, R.E.; Andresen, B.D. [Lawrence Livermore National Lab., CA (United States). Forensic Science Center

    1994-09-01

    A recent investigation involved automobile registration numbers as important evidentiary specimens. In California, as in most states, small, thin metallic decals are issued to owners of vehicles each year as the registration is renewed. The decals are applied directly to the license plate of the vehicle and typically on top of the previous year`s expired decal. To afford some degree of security, the individual registration decals have been designed to tear easily; they cannot be separated from each other, but can be carefully removed intact from the metal license plate by using a razor blade. In September 1993, the City of Livermore Police Department obtained a blue 1993 California decal that had been placed over an orange 1992 decal. The two decals were being investigated as possible evidence in a case involving vehicle registration fraud. To confirm the suspicion and implicate a suspect, the department needed to known the registration number on the bottom (completely covered) 1992 decal. The authors attempted to use intense and directed light to interrogate the colored stickers. Optical illumination using a filtered white-light source partially identified the latent number. However, the most successful technique used a tunable dye laser pumped by a pulsed Nd:YAG laser. By selectively tuning the wavelength and intensity of the dye laser, backlit illumination of the decals permitted visualization of the underlying registration number through the surface of the top sticker. With optimally-tuned wavelength and intensity, 100% accuracy was obtained in identifying the sequence of latent characters. The advantage of optical techniques is their completely nondestructive nature, thus preserving the evidence for further interrogation or courtroom presentation.

  13. Safety Evaluation Report on Tennessee Valley Authority: Browns Ferry Nuclear Performance Plan: Browns Ferry Unit 2 restart

    International Nuclear Information System (INIS)

    1989-04-01

    This safety evaluation report (SER) on the information submitted by the Tennessee Valley Authority (TVA) in its Nuclear Performance Plan, through Revision 2, for the Browns Ferry Nuclear Power Station and in supporting documents has been prepared by the US Nuclear Regulatory Commission staff. The plan addresses the plant-specific concerns requiring resolution before startup of Unit 2. The staff will inspect implementation of those programs. Where systems are common to Units 1 and 2 or to Units 2 and 3, the staff safety evaluations of those systems are included herein. 3 refs

  14. 2D-3D rigid registration to compensate for prostate motion during 3D TRUS-guided biopsy.

    Science.gov (United States)

    De Silva, Tharindu; Fenster, Aaron; Cool, Derek W; Gardi, Lori; Romagnoli, Cesare; Samarabandu, Jagath; Ward, Aaron D

    2013-02-01

    Three-dimensional (3D) transrectal ultrasound (TRUS)-guided systems have been developed to improve targeting accuracy during prostate biopsy. However, prostate motion during the procedure is a potential source of error that can cause target misalignments. The authors present an image-based registration technique to compensate for prostate motion by registering the live two-dimensional (2D) TRUS images acquired during the biopsy procedure to a preacquired 3D TRUS image. The registration must be performed both accurately and quickly in order to be useful during the clinical procedure. The authors implemented an intensity-based 2D-3D rigid registration algorithm optimizing the normalized cross-correlation (NCC) metric using Powell's method. The 2D TRUS images acquired during the procedure prior to biopsy gun firing were registered to the baseline 3D TRUS image acquired at the beginning of the procedure. The accuracy was measured by calculating the target registration error (TRE) using manually identified fiducials within the prostate; these fiducials were used for validation only and were not provided as inputs to the registration algorithm. They also evaluated the accuracy when the registrations were performed continuously throughout the biopsy by acquiring and registering live 2D TRUS images every second. This measured the improvement in accuracy resulting from performing the registration, continuously compensating for motion during the procedure. To further validate the method using a more challenging data set, registrations were performed using 3D TRUS images acquired by intentionally exerting different levels of ultrasound probe pressures in order to measure the performance of our algorithm when the prostate tissue was intentionally deformed. In this data set, biopsy scenarios were simulated by extracting 2D frames from the 3D TRUS images and registering them to the baseline 3D image. A graphics processing unit (GPU)-based implementation was used to improve the

  15. Author Details

    African Journals Online (AJOL)

    Koffi, E. Vol 80 (2014) - Articles Evaluation des proprietes antioxidantes et biologiques de farines infantiles a base d'igname/soja/sources vegetales de mineraux. Abstract PDF. ISSN: 1997-5902. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

  16. Author Details

    African Journals Online (AJOL)

    Dublin-Green, M. Vol 7 (2005) - Articles Quality evaluation of yogurts produced commercially In Lagos, Nigeria Abstract PDF. ISSN: 1119-023X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  17. Author Details

    African Journals Online (AJOL)

    Ademolu, A. A.. Vol 11, No 1-2 (2015) - Articles Laboratory Evaluation of Insecticidal Activities of Some Botanicals against Four Insect Pests of Honey Bees (Apis mellifera L.) Abstract PDF. ISSN: 0331-5428. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

  18. Author Details

    African Journals Online (AJOL)

    Onwubiko, CPC. Vol 10, No 1-2 (2010) - Articles Succession Planning In Academic Libraries In Owerri, Imo State, Nigeria: An Evaluative Study Abstract PDF. ISSN: 1596-5422. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

  19. Author Details

    African Journals Online (AJOL)

    Fasina, E.P. Vol 22, No 1 (2015) - Articles Evaluation of a flexible column-based access control security model for medical-based information. Abstract. ISSN: 2006-5523. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

  20. Author Details

    African Journals Online (AJOL)

    Pretorius, Elias. Vol 19, No 2 (2015) - Articles The role of cardiac CT angiography in the pre- and postoperative evaluation of tetralogy of Fallot Abstract PDF. ISSN: 2078-6778. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

  1. Author Details

    African Journals Online (AJOL)

    Idowu, OO. Vol 8, No 1 (2003) - Articles Evaluation of Different Substrates and Combinations on the Growth of Pleurotus pulmonarius (Fries) Quelet (Sajor-caju) Details. ISSN: 1118-2733. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Wudil, Alhassan M. Vol 2, No 2 (2005) - Articles Evaluation of anti-snake venom activity of the aqueous root extract of Securidaca longipedunculata in rats. Abstract. ISSN: 0189-8442. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Jatsa, H.B. Vol 6, No 3 (2009) - Articles Evaluation of the in vivo activity of different concentrations of Clerodendrum umbellatum poir against Schistosoma mansoni infection in mice. Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's ...

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    Okubanjo, AO. Vol 7, No 3 (2011) - Articles Carcass and primal cuts yield evaluation of African antelope (Antilope cervicapra) caught at Ago-Iwoye, Ogun state, Nigeria Abstract. ISSN: 0794-4721. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    Builders, P F. Vol 12 (2007) - Articles Evaluation of the controlled release potential of. Abstract PDF. ISSN: 1118-1028. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER ...

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    Jiya, EZ. Vol 8, No 1 (2010) - Articles Haematological evaluation of broilers administered probiotics (lactobacillus bulgaricus) Abstract. ISSN: 1597-0906. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of ...

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    Aadum, EJ. Vol 9, No 1 (2012) - Articles Evaluation of the Antidiarrhoeal Activity of the Aqueous Rhizome Extract of Curcuma Longa Abstract. ISSN: 1596-8499. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Al-Samarai, FR. Vol 5, No 1 (2015) - Articles Comparison of several methods of sires evaluation for total milk yield in a herd of Holstein cows in Yemen Abstract PDF. ISSN: 2218-6050. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Yusif, S. A.. Vol 24, No 2 (2016) - Articles Evaluation of Growth Performance of Tomato in Response to Biochar and Arbuscular Mycorrhizal Fungi (Amf) Inoculation Abstract PDF. ISSN: 0794-5698. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    Lartey, KS. Vol 5, No 1 (2007) - Articles Evaluation Of A Multipurpose Tile Body Developed From Ghanaian Raw Materials Abstract · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL ...

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    Bada, JK. Vol 5, No 1 (2012) - Articles Evaluation of the Blended Learning approach to Teaching Software Engineering Abstract. ISSN: 2070-1748. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Okolie, NJC. Vol 16, No 2 (2007) - Articles Evaluation of Levamisole Activity on Ascaris lumbricoides and Hookworm Infections - A Therapeutic Trial Abstract. ISSN: 1116-1043. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Agu, MN. Vol 18 (2013) - Articles Evaluation of nuclear reaction cross section of some isotopes of plutonium at energy range 10-20 MeV Using OPTMAN code. Abstract PDF. ISSN: 1119-0221. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    Ahmad, A. Vol 9, No 6S (2017) - Articles Evaluation of RTD and thermocouple for PID temperature control in distributed control system laboratory. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Masrie, M. Vol 9, No 6S (2017) - Articles Evaluation of RTD and thermocouple for PID temperature control in distributed control system laboratory. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Saaid, M. F.. Vol 9, No 6S (2017) - Articles Evaluation of RTD and thermocouple for PID temperature control in distributed control system laboratory. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Agu, NN. Vol 3, No 4 (2009) - Articles Evaluating Students' Plagiarism in Higher Education Institutions Abstract PDF. ISSN: 2070-0083. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL ...

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    Olibie, E. Vol 3, No 4 (2009) - Articles Evaluating Students' Plagiarism in Higher Education Institutions Abstract PDF. ISSN: 2070-0083. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL ...

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    intelligence economique en Algerie : Evaluation et perspectives. Abstract. ISSN: 1012-0009. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Olabiyi, TI. Vol 9, No 3 (2010) - Articles Evaluation of sweet orange peel aqueous extract (citrus sinensis) as root –knot nematode suppressant. Abstract PDF. ISSN: 1119-7455. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Afshar, M. Vol 8, No 2 (2016): Special Issue: Part 2 - Articles Evaluating the effects of climate on weathering processes of rocks based on Peltier models in Kermanshah province. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More ...

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    Ofevwe, GE. Vol 22, No 1-2 (2010) - Articles Evaluation of the performance of primary schools in Oredo Local Government Area of Edo State in the school health programme. Abstract PDF. ISSN: 0794-7410. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More ...

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    Narsoo, J. Vol 22 (2016) - Articles Evaluation of GARCH-Type Models in Volatility and Value-At-Risk Forecasting: Evidences from USD/MUR Exchange Rates Abstract. ISSN: 1694-0342. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Ukegba, CI. Vol 20, No 1-4 (2008) - Articles Pregnancy and periodontal disease: 5 year clinical evaluation in Enugu, Nigeria Abstract. ISSN: 1115-0521. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of ...

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    Kabari, LG. Vol 28, No 1 (2009) - Research papers. Credit Risk Evaluation System: An Artificial Neural Network Approach Abstract PDF. ISSN: 2467-8821. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of ...

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    Sahbudin, R.K.Z.. Vol 9, No 3S (2017): Special Issue - Articles Performance evaluation of an efficient RZ-MQAM modulation scheme in all-optical OFDM transmission systems. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More ...

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    Adetimirin, Airen E. Vol 8, No 3 (2017) - Articles Evaluating use of institutional repositories by lecturers in Nigerian universities. Abstract PDF. ISSN: 2360-994X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Antigha, REE. Vol 12 (2013) - Articles Evaluation of Bamboo Porous Pipe as Line Source Emitter in Trickle Irrigation System Abstract PDF. ISSN: 1596-292X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions ...

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    Odhiambo, AO. Vol 8, No 2 (2014) - Articles Correlation of magnetic resonance imaging findings with arthroscopy in the evaluation of rotator cuff pathology. Abstract PDF. ISSN: 1994-1072. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Yahaya, M.F.. Vol 9, No 5S (2017): Special Issue - Articles Evaluation on knowledge extraction and machine learning in resolving Malay word ambiguity. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Reinecke, E. Vol 86, No 11 (1996) - Articles Evaluation of reflux oesophagitis with technetium-99m-labelled sucralfate. Abstract PDF. ISSN: 0256-95749. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of ...

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    Swigelaar, RE. Vol 18, No 2 (2012) - Articles Role of ultrasound in the evaluation of rotator cuff muscle quality: A review. Abstract. ISSN: 1117-4315. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Fono-Tamo, R.S.. Vol 11, No 2 (2016) - Articles Physico-thermal characteristics and health risk evaluation of randomly selected brake pads in the Nigerian market. Abstract. ISSN: 0795-5111. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Bourebia, Mounira. Vol 33 (2016) - Articles Evaluation of surface quality by Fractal Dimension and Volume Parameters Abstract PDF. ISSN: 2352-9717. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of ...

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    Admasu, Assefa. Vol 22, No 2 (1999) - Articles Preliminary evaluation of Phytomyza orobanchia (Diptera: Agromyzidae) as a controller of Orobanche spp in Ethiopia Details PDF. ISSN: 2520–7997. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    Emejulu, MJ. Vol 20, No 4 (2016) - Articles Evaluation of bisphenol A, physicochemical properties and microbial characterization of borehole water stored in plastic containers. Abstract PDF. ISSN: 1119-8362. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More ...

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    Raeesdana, Azade. Vol 15, No 1 (2018) - Articles Chemical composition of essential oil and evaluation of acute and sub-acute toxicity of Dorema ammoniacum d. Don. Oleo-gum-resin in rats. Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

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    Zhang, Zi-Ran. Vol 14, No 1 (2017) - Articles Evaluation of effectiveness in a novel wound healing ointment-crocodile oil burn ointment. Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Xiong, You-Xiong. Vol 14, No 1 (2017) - Articles Evaluation of effectiveness in a novel wound healing ointment-crocodile oil burn ointment. Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms ...

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    Brisibe, Ebiamadon Andi. Vol 20, No 1 (2009) - Articles Evaluation of Starch Biodegradable Plastics Derived from Cassava and Their Rates of Degradation in Soil Abstract PDF. ISSN: 01891731. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    Akalu, N. Vol 25, No 1 (2007) - Articles Evaluation of Antimicrobial Activity of the Essential Oil of Myrtus communis L. and Its Formulation into Gum Paint Abstract. ISSN: 1029-5933. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Adam, B. Vol 9, No 3S (2017): Special Issue - Articles Performance evaluation of faster R-CNN on GPU for object detection. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions ...

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    Aboufatima, R. Vol 26 (2010) - Articles Evaluation des Activities Analgesique et Antipyretique de Punica granatum. Abstract. ISSN: 0303-691X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Deutsch, C. Vol 9, No 4 (2012) - Articles Measuring change in vulnerable adolescents: Findings from a peer education evaluation in South Africa Abstract PDF. ISSN: 1813-4424. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Ebun-Igbeare, Ernest. Vol 20, No 2 (2016) - Articles Municipal water resources management: evaluation of water consumption by car wash facilities in Bauchi Town, Nigeria Abstract PDF. ISSN: 1119-8362. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    Odeniran, P.O.. Vol 30, No 2 (2015) - Articles Evaluating the effectiveness of varying concentrations of permethrin on ticks of genus Aponoma on Royal Pythons (Python Regius) Abstract. ISSN: 0856-1451. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    Adesina, SK. Vol 19 (2007): - Articles Neuropharmacological Evaluation of Aridanin, a Glycoside Isolated from Tetrapleura tetraptera Fruit Abstract. ISSN: 1015-079X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Ekosse, Georges-Ivo E. Vol 5, No 2 (2005) - Articles Diagnostic evaluation of bentonitic and kaolinitic clayey materials for ceramic applications. Abstract PDF · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions ...

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    Ofakansi, KC. Vol 10, No 1 (2013) - Articles Evaluation of the microbiological quality and stability of folic acid tablets formulated with sorghum starch. Abstract. ISSN: 1596-8499. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Ramdial, Pratistadevi Kumari. Vol 36, No 1 (2017) - Articles Clinico-pathological evaluation of two patients presenting with the neuromyelitis optica syndrome. Abstract. ISSN: 1015-8618. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Oumtanaga, A. Vol 7, No 1 (2005): Serie E - Articles Evaluation de la mise en ceuvre des services du protocole IPV6 dans un environnement de laboratoire. Abstract. ISSN: 2413-354X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Utu-Baku, Ashang Bonifice. Vol 11, No 5 (2017) - Articles Phytochemical evaluation and GC-MS analysis of Hyptis verticillata cultivated in Calabar Cross River State, Nigeria Abstract PDF. ISSN: 1997-342X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More ...

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    Anosike, Chikaodili. Vol 11, No 5 (2017) - Articles Phytochemical evaluation and GC-MS analysis of Hyptis verticillata cultivated in Calabar Cross River State, Nigeria Abstract PDF. ISSN: 1997-342X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    Tiwari, S. Vol 9, No 5S (2017): Special Issue - Articles Mergers and acquisitions's impact on financial performance: an evaluation with perspective of time. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Okigbo, EL. Vol 12, No 1 (2013) - Articles Formulation and Evaluation of Glutaraldehyde-Crosslinked Chitosan Microparticles for the Delivery of Ibuprofen Abstract PDF. ISSN: 1596-9827. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

  16. Summer Camp Registrations 2018

    CERN Multimedia

    Staff Association

    2018-01-01

    Registration for the CERN SA Summer camp, for children from 4 to 6 years old, is now open. The general conditions are available on the EVE and School website: http://nurseryschool.web.cern.ch For further questions, please contact us by email at  Summer.Camp@cern.ch An inscription per week is proposed, for 450.-CHF/week, lunch included. The camp will be open on weeks 27, 28, 29 and 30, from 8:30 am to 5:30 pm. This year the theme will be Vivaldi’s Four Seasons.

  17. The Household Registration System

    Directory of Open Access Journals (Sweden)

    2000-06-01

    Full Text Available Although longitudinal experimental community health research is crucial to testing hypotheses about the demographic impact of health technologies, longitudinal demographic research field stations are rare, owing to the complexity and high cost of developing requisite computer software systems. This paper describes the Household Registration System (HRS, a software package that has been used for the rapid development of eleven surveillance systems in sub-Saharan Africa and Asia. Features of the HRS automate software generation for a family of surveillance applications, obviating the need for new and complex computer software systems for each new longitudinal demographic study.

  18. Registration Summer Camp 2016

    CERN Multimedia

    2016-01-01

    Reminder: registration for the CERN Staff Association Summer Camp is now open for children from 4 to 6 years old.   More information on the website: http://nurseryschool.web.cern.ch/. The summer camp is open to all children. The proposed cost is 480.-CHF/week, lunch included. The camp will be open weeks 27, 28, 29 and 30, from 8:30 a.m. to 5:30 p.m. For further questions, you are welcome to contact us by email at Summer.Camp@cern.ch. CERN Staff Association

  19. Error estimation of deformable image registration of pulmonary CT scans using convolutional neural networks.

    Science.gov (United States)

    Eppenhof, Koen A J; Pluim, Josien P W

    2018-04-01

    Error estimation in nonlinear medical image registration is a nontrivial problem that is important for validation of registration methods. We propose a supervised method for estimation of registration errors in nonlinear registration of three-dimensional (3-D) images. The method is based on a 3-D convolutional neural network that learns to estimate registration errors from a pair of image patches. By applying the network to patches centered around every voxel, we construct registration error maps. The network is trained using a set of representative images that have been synthetically transformed to construct a set of image pairs with known deformations. The method is evaluated on deformable registrations of inhale-exhale pairs of thoracic CT scans. Using ground truth target registration errors on manually annotated landmarks, we evaluate the method's ability to estimate local registration errors. Estimation of full domain error maps is evaluated using a gold standard approach. The two evaluation approaches show that we can train the network to robustly estimate registration errors in a predetermined range, with subvoxel accuracy. We achieved a root-mean-square deviation of 0.51 mm from gold standard registration errors and of 0.66 mm from ground truth landmark registration errors.

  20. Semiautomated Multimodal Breast Image Registration

    Directory of Open Access Journals (Sweden)

    Charlotte Curtis

    2012-01-01

    However, due to the highly deformable nature of breast tissues, comparison of 3D and 2D modalities is a challenge. To enable this comparison, a registration technique was developed to map features from 2D mammograms to locations in the 3D image space. This technique was developed and tested using magnetic resonance (MR images as a reference 3D modality, as MR breast imaging is an established technique in clinical practice. The algorithm was validated using a numerical phantom then successfully tested on twenty-four image pairs. Dice's coefficient was used to measure the external goodness of fit, resulting in an excellent overall average of 0.94. Internal agreement was evaluated by examining internal features in consultation with a radiologist, and subjective assessment concludes that reasonable alignment was achieved.

  1. Do action learning sets facilitate collaborative, deliberative learning?: A focus group evaluation of Graduate Entry Pre-registration Nursing (GEN) students' experience.

    Science.gov (United States)

    Maddison, Charlotte; Strang, Gus

    2018-01-01

    The aim of this study was to investigate if by participating in action learning sets, Graduate Entry Pre-registration Nursing (GEN) students were able to engage in collaborative and deliberative learning. A single focus group interview involving eleven participants was used to collect data. Data analysis identified five themes; collaborative learning; reflection; learning through case study and problem-solving; communication, and rejection of codified learning. The themes are discussed and further analysed in the context of collaborative and deliberative learning. The evidence from this small scale study suggests that action learning sets do provide an environment where collaborative and deliberative learning can occur. However, students perceived some of them, particularly during year one, to be too 'teacher lead', which stifled learning. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Study of three-dimensional PET and MR image registration based on higher-order mutual information

    International Nuclear Information System (INIS)

    Ren Haiping; Chen Shengzu; Wu Wenkai; Yang Hu

    2002-01-01

    Mutual information has currently been one of the most intensively researched measures. It has been proven to be accurate and effective registration measure. Despite the general promising results, mutual information sometimes might lead to misregistration because of neglecting spatial information and treating intensity variations with undue sensitivity. An extension of mutual information framework was proposed in which higher-order spatial information regarding image structures was incorporated into the registration processing of PET and MR. The second-order estimate of mutual information algorithm was applied to the registration of seven patients. Evaluation from Vanderbilt University and authors' visual inspection showed that sub-voxel accuracy and robust results were achieved in all cases with second-order mutual information as the similarity measure and with Powell's multidimensional direction set method as optimization strategy

  3. A Methodology for Evaluating User Perceptions of the Delivery of ICT Services: a comparative study of six UK local authorities

    Directory of Open Access Journals (Sweden)

    Les Worrall

    2000-11-01

    Full Text Available Evaluating and managing the effective delivery of ICT services is an issue that has been brought into sharper relief recently. This has been particularly prevalent in the UK public sector where the growing emphasis on formalised client-contractor relationships, outsourcing and benchmarking (both between local authorities and between local authorities and private sector organisations has meant that the definition of service standards and agreeing performance criteria has attracted considerable practitioner attention. This research is based on 295 interviews conducted in six UK local authorities. The investigation used both gap analysis and perceptual mapping techniques to develop an understanding of the aspects of ICT service delivery that users' value most in conjunction with an assessment of how well they perceive their ICT department is performing on these criteria. The paper exposes considerable differences in the relative performance of the six local authorities from both the gap analysis and the perceptual mapping elements of the investigation. The methodology is shown to provide an effective way of identifying key performance issues from the user perspective and benchmarking service performance across organisations.

  4. Study of national registration systems for health records of radiation workers. National radiation dose registration system

    International Nuclear Information System (INIS)

    Nakagawa, Haruo; Kanda, Keiji

    1999-01-01

    A national radiation dose registration system is proposed in this paper. In Japan, only one radiation dose registration system is partly effective. It is applied for workers in nuclear power plants which are under control of regulatory laws for nuclear reactors. The total system was proposed previously by the Committee for Compensation Claims of Nuclear Accidents. The reason for the delay in establishing a registration system for all radiation workers is supposedly a lack of effort to adjust differences among items in radiation protection laws and the promotion of public acceptance to atomic power. Items about dose recordings, record keeping and dose-record reporting in all of the radiation regulatory laws are compared to each other, and items were extracted for revision. (author)

  5. Influence of heart rhythm, breathing and arm position during computed tomography scanning on the registration accuracy of electro anatomical map (EAM) images, left atrium three-dimensional computed tomography angiography images, and fluoroscopy time during ablation to treat atrial fibrillation

    International Nuclear Information System (INIS)

    Chono, Taiki; Shimoshige, Shinya; Yoshikawa, Kenta; Mizonobe, Kazuhusa; Ogura, Keishi

    2013-01-01

    In CARTOMERGE for treatment of atrial fibrillation (AF) by ablation, by integrating electro anatomical map (EAM) and left atrium three-dimensional computed tomography angiography (3D-CTA) images, identification of the ablation points is simplified and the procedure can be made carried out more rapidly. However, the influence that heart rhythm, breathing and arm position during CT scanning have on registration accuracy and fluoroscopy time is not clear. To clarify the influence on registration accuracy and fluoroscopy time of heart rhythm, breathing and arm position during CT scanning. The patients were CT-scanned during both sinus rhythm (SR) and AF in each study subject. We evaluated the registration accuracy of images reconstructed between the cardiac cycle and assessed the registration accuracy and fluoroscopy time of images obtained during inspiratory breath-hold, expiratory breath-hold and up and down position of the arm. Although the registration accuracy of the EAM image and left atrium 3D-CTA image showed a significant difference during SR, no significant difference was seen during AF. Expiratory breath-hold and down position of the arm resulted in the highest registration accuracy and the shortest fluoroscopy time. However, arm position had no significant effect on registration accuracy. Heart rhythm and breathing during CT scanning have a significant effect on the registration accuracy of EAM images, left atrium 3D-CTA images, and fluoroscopy time. (author)

  6. Pesticide registration, distribution and use practices in Ghana

    NARCIS (Netherlands)

    Onwona Kwakye, Michael; Mengistie, Belay; Ofosu-Anim, John; Nuer, Alexander Tetteh K.; Den Brink, van Paul J.

    2018-01-01

    Ghana has implemented regulation on the registration, distribution and usage of pesticides in order to evaluate their environmental and human health effects. However, environmental monitoring and certified laboratories for pesticide analysis are lacking. Pesticide misuse, misapplication,

  7. AUTHOR GUIDELINES

    Directory of Open Access Journals (Sweden)

    Chief Editor

    2014-12-01

    Full Text Available AUTHOR GUIDELINESIndian Journal of Community Health (IJCH accepts only online submission of manuscript(s by using Open Journal software (OJS at http://www.iapsmupuk.org/journal/index.php/IJCH/loginOnline SubmissionsAlready have a Username/Password for Indian Journal of Community Health (IJCH? GO TO LOGINNeed a Username/Password?GO TO REGISTRATIONNote: Registration and login are required to submit items online and to track the status of current submissions.Author GuidelinesIJCH strictly adheres on the recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals as per the standard universal guidelines given by International Committee of Medical Journal Editors (ICMJE - Recommendations for Uniform Requirements for Manuscripts. Authors are requested to visit http://www.icmje.org/index.html before making online submission of their manuscript(s.SectionsEditorial:On issues of current public health needAbout 1000 – 1200 wordsReferences: 5 – 10 (PubMed - Citation preferredInvited Commentary:Brief, provocative, opinionated communicationsOn issues of current public health needMain Text: 750-1000 words excluding referencesReferences: 5 – 10 (PubMed - Citation preferredOriginal Article:Articles from Original ResearchStructured abstract: 250 wordsMain Text: 2500 - 3000 words, IMRD formatKey Words: 5 - 8References: 20 – 25 (PubMed - Citation preferredTables / Figures: 3 – 4*Certificate of clearance from respective Institutional Ethical Committee (IECReview Article:On subject of public health relevanceAbstract: 250 wordsMain Text: 2500 - 3000 wordsKey Words: 3 - 4References: 20 – 25 (PubMed - Citation preferredTables / Figures: 3 – 4Short Communication / Article:Short report of a research project / outbreakMain Text : 1000 – 1200 wordsReferences: 10 – 15 (PubMed - Citation preferredTable / Figure: 01*Certificate of clearance from respective Institutional Ethical Committee (IECReport from the field

  8. Commissioning of a proton gantry equipped with dual x-ray imagers and a robotic patient positioner, and evaluation of the accuracy of single-beam image registration for this system

    International Nuclear Information System (INIS)

    Wang, Ning; Ghebremedhin, Abiel; Patyal, Baldev

    2015-01-01

    Purpose: To check the accuracy of a gantry equipped with dual x-ray imagers and a robotic patient positioner for proton radiotherapy, and to evaluate the accuracy and feasibility of single-beam registration using the robotic positioner. Methods: One of the proton treatment rooms at their institution was upgraded to include a robotic patient positioner (couch) with 6 degrees of freedom and dual orthogonal kilovoltage x-ray imaging panels. The wander of the proton beam central axis, the wander of the beamline, and the orthogonal image panel crosswires from the gantry isocenter were measured for different gantry angles. The couch movement accuracy and couch wander from the gantry isocenter were measured for couch loadings of 50–300 lb with couch rotations from 0° to ±90°. The combined accuracy of the gantry, couch, and imagers was checked using a custom-made 30 × 30 × 30 cm 3 Styrofoam phantom with beekleys embedded in it. A treatment in this room can be set up and registered at a setup field location, then moved precisely to any other treatment location without requiring additional image registration. The accuracy of the single-beam registration strategy was checked for treatments containing multiple beams with different combinations of gantry angles, couch yaws, and beam locations. Results: The proton beam central axis wander from the gantry isocenter was within 0.5 mm with gantry rotations in both clockwise (CW) and counterclockwise (CCW) directions. The maximum wander of the beamline and orthogonal imager crosswire centers from the gantry isocenter were within 0.5 and 0.8 mm, respectively, with the gantry rotations in CW and CCW directions. Vertical and horizontal couch wanders from the gantry isocenter were within 0.4 and 1.3 mm, respectively, for couch yaw from 0° to ±90°. For a treatment with multiple beams with different gantry angles, couch yaws, and beam locations, the measured displacements of treatment beam locations from the one based on the

  9. 32 CFR 1615.1 - Registration.

    Science.gov (United States)

    2010-07-01

    ... registration card or other method of registration prescribed by the Director of Selective Service by a person... the records (master computer file) of the Selective Service System. Registration is completed when... Director include completing a Selective Service Registration Card at a classified Post Office, registration...

  10. Vision-based markerless registration using stereo vision and an augmented reality surgical navigation system: a pilot study

    International Nuclear Information System (INIS)

    Suenaga, Hideyuki; Tran, Huy Hoang; Liao, Hongen; Masamune, Ken; Dohi, Takeyoshi; Hoshi, Kazuto; Takato, Tsuyoshi

    2015-01-01

    This study evaluated the use of an augmented reality navigation system that provides a markerless registration system using stereo vision in oral and maxillofacial surgery. A feasibility study was performed on a subject, wherein a stereo camera was used for tracking and markerless registration. The computed tomography data obtained from the volunteer was used to create an integral videography image and a 3-dimensional rapid prototype model of the jaw. The overlay of the subject’s anatomic site and its 3D-IV image were displayed in real space using a 3D-AR display. Extraction of characteristic points and teeth matching were done using parallax images from two stereo cameras for patient-image registration. Accurate registration of the volunteer’s anatomy with IV stereoscopic images via image matching was done using the fully automated markerless system, which recognized the incisal edges of the teeth and captured information pertaining to their position with an average target registration error of < 1 mm. These 3D-CT images were then displayed in real space with high accuracy using AR. Even when the viewing position was changed, the 3D images could be observed as if they were floating in real space without using special glasses. Teeth were successfully used for registration via 3D image (contour) matching. This system, without using references or fiducial markers, displayed 3D-CT images in real space with high accuracy. The system provided real-time markerless registration and 3D image matching via stereo vision, which, combined with AR, could have significant clinical applications. The online version of this article (doi:10.1186/s12880-015-0089-5) contains supplementary material, which is available to authorized users

  11. Hong Kong Hospital Authority resource efficiency evaluation: Via a novel DEA-Malmquist model and Tobit regression model.

    Science.gov (United States)

    Guo, Hainan; Zhao, Yang; Niu, Tie; Tsui, Kwok-Leung

    2017-01-01

    The Hospital Authority (HA) is a statutory body managing all the public hospitals and institutes in Hong Kong (HK). In recent decades, Hong Kong Hospital Authority (HKHA) has been making efforts to improve the healthcare services, but there still exist some problems like unfair resource allocation and poor management, as reported by the Hong Kong medical legislative committee. One critical consequence of these problems is low healthcare efficiency of hospitals, leading to low satisfaction among patients. Moreover, HKHA also suffers from the conflict between limited resource and growing demand. An effective evaluation of HA is important for resource planning and healthcare decision making. In this paper, we propose a two-phase method to evaluate HA efficiency for reducing healthcare expenditure and improving healthcare service. Specifically, in Phase I, we measure the HKHA efficiency changes from 2000 to 2013 by applying a novel DEA-Malmquist index with undesirable factors. In Phase II, we further explore the impact of some exogenous factors (e.g., population density) on HKHA efficiency by Tobit regression model. Empirical results show that there are significant differences between the efficiencies of different hospitals and clusters. In particular, it is found that the public hospital serving in a richer district has a relatively lower efficiency. To a certain extent, this reflects the socioeconomic reality in HK that people with better economic condition prefers receiving higher quality service from the private hospitals.

  12. Consistency of parametric registration in serial MRI studies of brain tumor progression

    International Nuclear Information System (INIS)

    Mang, Andreas; Buzug, Thorsten M.; Schnabel, Julia A.; Crum, William R.; Modat, Marc; Ourselin, Sebastien; Hawkes, David J.; Camara-Rey, Oscar; Palm, Christoph; Caseiras, Gisele Brasil; Jaeger, H.R.

    2008-01-01

    The consistency of parametric registration in multi-temporal magnetic resonance (MR) imaging studies was evaluated. Serial MRI scans of adult patients with a brain tumor (glioma) were aligned by parametric registration. The performance of low-order spatial alignment (6/9/12 degrees of freedom) of different 3D serial MR-weighted images is evaluated. A registration protocol for the alignment of all images to one reference coordinate system at baseline is presented. Registration results were evaluated for both, multimodal intra-timepoint and mono-modal multi-temporal registration. The latter case might present a challenge to automatic intensity-based registration algorithms due to ill-defined correspondences. The performance of our algorithm was assessed by testing the inverse registration consistency. Four different similarity measures were evaluated to assess consistency. Careful visual inspection suggests that images are well aligned, but their consistency may be imperfect. Sub-voxel inconsistency within the brain was found for allsimilarity measures used for parametric multi-temporal registration. T1-weighted images were most reliable for establishing spatial correspondence between different timepoints. The parametric registration algorithm is feasible for use in this application. The sub-voxel resolution mean displacement error of registration transformations demonstrates that the algorithm converges to an almost identical solution for forward and reverse registration. (orig.)

  13. 16 CFR 1130.8 - Requirements for Web site registration or alternative e-mail registration.

    Science.gov (United States)

    2010-01-01

    ... registration. (a) Link to registration page. The manufacturer's Web site, or other Web site established for the... web page that goes directly to “Product Registration.” (b) Purpose statement. The registration page... registration page. The Web site registration page shall request only the consumer's name, address, telephone...

  14. 21 CFR 1301.36 - Suspension or revocation of registration; suspension of registration pending final order...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Suspension or revocation of registration; suspension of registration pending final order; extension of registration pending final order. 1301.36... registration pending final order; extension of registration pending final order. (a) For any registration...

  15. Hand-eye calibration using a target registration error model.

    Science.gov (United States)

    Chen, Elvis C S; Morgan, Isabella; Jayarathne, Uditha; Ma, Burton; Peters, Terry M

    2017-10-01

    Surgical cameras are prevalent in modern operating theatres and are often used as a surrogate for direct vision. Visualisation techniques (e.g. image fusion) made possible by tracking the camera require accurate hand-eye calibration between the camera and the tracking system. The authors introduce the concept of 'guided hand-eye calibration', where calibration measurements are facilitated by a target registration error (TRE) model. They formulate hand-eye calibration as a registration problem between homologous point-line pairs. For each measurement, the position of a monochromatic ball-tip stylus (a point) and its projection onto the image (a line) is recorded, and the TRE of the resulting calibration is predicted using a TRE model. The TRE model is then used to guide the placement of the calibration tool, so that the subsequent measurement minimises the predicted TRE. Assessing TRE after each measurement produces accurate calibration using a minimal number of measurements. As a proof of principle, they evaluated guided calibration using a webcam and an endoscopic camera. Their endoscopic camera results suggest that millimetre TRE is achievable when at least 15 measurements are acquired with the tracker sensor ∼80 cm away on the laparoscope handle for a target ∼20 cm away from the camera.

  16. Significantly reducing registration time in IGRT using graphics processing units

    DEFF Research Database (Denmark)

    Noe, Karsten Østergaard; Denis de Senneville, Baudouin; Tanderup, Kari

    2008-01-01

    respiration phases in a free breathing volunteer and 41 anatomical landmark points in each image series. The registration method used is a multi-resolution GPU implementation of the 3D Horn and Schunck algorithm. It is based on the CUDA framework from Nvidia. Results On an Intel Core 2 CPU at 2.4GHz each...... registration took 30 minutes. On an Nvidia Geforce 8800GTX GPU in the same machine this registration took 37 seconds, making the GPU version 48.7 times faster. The nine image series of different respiration phases were registered to the same reference image (full inhale). Accuracy was evaluated on landmark...

  17. Object-constrained meshless deformable algorithm for high speed 3D nonrigid registration between CT and CBCT

    International Nuclear Information System (INIS)

    Chen Ting; Kim, Sung; Goyal, Sharad; Jabbour, Salma; Zhou Jinghao; Rajagopal, Gunaretnum; Haffty, Bruce; Yue Ning

    2010-01-01

    Purpose: High-speed nonrigid registration between the planning CT and the treatment CBCT data is critical for real time image guided radiotherapy (IGRT) to improve the dose distribution and to reduce the toxicity to adjacent organs. The authors propose a new fully automatic 3D registration framework that integrates object-based global and seed constraints with the grayscale-based ''demons'' algorithm. Methods: Clinical objects were segmented on the planning CT images and were utilized as meshless deformable models during the nonrigid registration process. The meshless models reinforced a global constraint in addition to the grayscale difference between CT and CBCT in order to maintain the shape and the volume of geometrically complex 3D objects during the registration. To expedite the registration process, the framework was stratified into hierarchies, and the authors used a frequency domain formulation to diffuse the displacement between the reference and the target in each hierarchy. Also during the registration of pelvis images, they replaced the air region inside the rectum with estimated pixel values from the surrounding rectal wall and introduced an additional seed constraint to robustly track and match the seeds implanted into the prostate. The proposed registration framework and algorithm were evaluated on 15 real prostate cancer patients. For each patient, prostate gland, seminal vesicle, bladder, and rectum were first segmented by a radiation oncologist on planning CT images for radiotherapy planning purpose. The same radiation oncologist also manually delineated the tumor volumes and critical anatomical structures in the corresponding CBCT images acquired at treatment. These delineated structures on the CBCT were only used as the ground truth for the quantitative validation, while structures on the planning CT were used both as the input to the registration method and the ground truth in validation. By registering the planning CT to the CBCT, a

  18. Preparedness of newly qualified midwives to deliver clinical care: an evaluation of pre-registration midwifery education through an analysis of key events.

    Science.gov (United States)

    Skirton, Heather; Stephen, Nicole; Doris, Faye; Cooper, Maggie; Avis, Mark; Fraser, Diane M

    2012-10-01

    this study was part of a larger project commissioned to ascertain whether midwife teachers bring a unique contribution to the preparation of midwives for practice. The aim of this phase was to determine whether the student midwives' educational programme had equipped them to practise competently after entry to the professional register. this was a prospective, longitudinal qualitative study, using participant diaries to collect data. data were collected from newly qualified midwives during the initial six months after they commenced their first post as a qualified midwife. the potential participants were all student midwives who were completing their education at one of six Universities (three in England, one in Scotland, one in Wales and one in Northern Ireland). Diary data were submitted by 35 newly qualified midwives; 28 were graduates of the three year programme and seven of the shortened programme. diary entries were analysed using thematic analysis (Braun and Clarke, 2006), with a focus on identification of key events in the working lives of the newly qualified midwives. A total of 263 key events were identified, under three main themes: (1) impact of the event on confidence, (2) gaps in knowledge or experience and (3) articulated frustration, conflict or distress. essentially, pre-registration education, delivered largely by midwife teachers and supported by clinical mentors, has been shown to equip newly qualified midwives to work effectively as autonomous practitioners caring for mothers and babies. While newly qualified midwives are able to cope with a range of challenging clinical situations in a safe manner, they lack confidence in key areas. Positive reinforcement by supportive colleagues plays a significant role in enabling them to develop as practitioners. whilst acknowledging the importance of normality in childbearing there is a need within the curriculum to enable midwives to recognise and respond to complex care situations by providing theory

  19. Confidence and authority through new knowledge: An evaluation of the national educational programme in paediatric oncology nursing in Sweden.

    Science.gov (United States)

    Pergert, Pernilla; Af Sandeberg, Margareta; Andersson, Nina; Márky, Ildikó; Enskär, Karin

    2016-03-01

    There is a lack of nurse specialists in many paediatric hospitals in Sweden. This lack of competence is devastating for childhood cancer care because it is a highly specialised area that demands specialist knowledge. Continuing education of nurses is important to develop nursing practice and also to retain them. The aim of this study was to evaluate a Swedish national educational programme in paediatric oncology nursing. The nurses who participated came from all of the six paediatric oncology centres as well as from general paediatric wards. At the time of the evaluation, three groups of registered nurses (n=66) had completed this 2year, part-time educational programme. A study specific questionnaire, including closed and open-ended questions was sent to the 66 nurses and 54 questionnaires were returned. Answers were analysed using descriptive statistics and qualitative content analysis. The results show that almost all the nurses (93%) stayed in paediatric care after the programme. Furthermore, 31% had a position in management or as a consultant nurse after the programme. The vast majority of the nurses (98%) stated that the programme had made them more secure in their work. The nurses were equipped, through education, for paediatric oncology care which included: knowledge generating new knowledge; confidence and authority; national networks and resources. They felt increased confidence in their roles as paediatric oncology nurses as well as authority in their encounters with families and in discussions with co-workers. New networks and resources were appreciated and used in their daily work in paediatric oncology. The programme was of importance to the career of the individual nurse and also to the quality of care given to families in paediatric oncology. The national educational programme for nurses in Paediatric Oncology Care meets the needs of the highly specialised care. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Image Registration: A Necessary Evil

    Science.gov (United States)

    Bell, James; McLachlan, Blair; Hermstad, Dexter; Trosin, Jeff; George, Michael W. (Technical Monitor)

    1995-01-01

    Registration of test and reference images is a key component of nearly all PSP data reduction techniques. This is done to ensure that a test image pixel viewing a particular point on the model is ratioed by the reference image pixel which views the same point. Typically registration is needed to account for model motion due to differing airloads when the wind-off and wind-on images are taken. Registration is also necessary when two cameras are used for simultaneous acquisition of data from a dual-frequency paint. This presentation will discuss the advantages and disadvantages of several different image registration techniques. In order to do so, it is necessary to propose both an accuracy requirement for image registration and a means for measuring the accuracy of a particular technique. High contrast regions in the unregistered images are most sensitive to registration errors, and it is proposed that these regions be used to establish the error limits for registration. Once this is done, the actual registration error can be determined by locating corresponding points on the test and reference images, and determining how well a particular registration technique matches them. An example of this procedure is shown for three transforms used to register images of a semispan model. Thirty control points were located on the model. A subset of the points were used to determine the coefficients of each registration transform, and the error with which each transform aligned the remaining points was determined. The results indicate the general superiority of a third-order polynomial over other candidate transforms, as well as showing how registration accuracy varies with number of control points. Finally, it is proposed that image registration may eventually be done away with completely. As more accurate image resection techniques and more detailed model surface grids become available, it will be possible to map raw image data onto the model surface accurately. Intensity

  1. Pro Forma Registration of Companies

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2010-01-01

    The article analyses the view taken by Community law on companies' pro forma registration in another EU or EEA country. Community law recognises pro forma registration under company law, i.e. a brass plate is sufficient, whereas it does not recognise pro forma registration under tax law, i.......e. a brass plate is not sufficient. The article provides reasons for the differential treatment of the two contexts and clarifies the difference on the basis of the Hubbard criterion, in which it was ruled that the effectiveness of Community law cannot vary according to the various branches of national law....

  2. Computer Registration Becoming Mandatory

    CERN Multimedia

    2003-01-01

    Following the decision by the CERN Management Board (see Weekly Bulletin 38/2003), registration of all computers connected to CERN's network will be enforced and only registered computers will be allowed network access. The implementation has started with the IT buildings, continues with building 40 and the Prevessin site (as of Tuesday 4th November 2003), and will cover the whole of CERN before the end of this year. We therefore recommend strongly that you register all your computers in CERN's network database (Ethernet and wire-less cards) as soon as possible without waiting for the access restriction to take force. This will allow you accessing the network without interruption and help IT service providers to contact you in case of problems (security problems, viruses, etc.) • Users WITH a CERN computing account register at: http://cern.ch/register/ (CERN Intranet page) • Visitors WITHOUT a CERN computing account (e.g. short term visitors) register at: http://cern.ch/registerVisitorComp...

  3. Computer Registration Becoming Mandatory

    CERN Multimedia

    2003-01-01

    Following the decision by the CERN Management Board (see Weekly Bulletin 38/2003), registration of all computers connected to CERN's network will be enforced and only registered computers will be allowed network access. The implementation has started with the IT buildings, continues with building 40 and the Prevessin site (as of Tuesday 4th November 2003), and will cover the whole of CERN before the end of this year. We therefore recommend strongly that you register all your computers in CERN's network database including all network access cards (Ethernet AND wireless) as soon as possible without waiting for the access restriction to take force. This will allow you accessing the network without interruption and help IT service providers to contact you in case of problems (e.g. security problems, viruses, etc.) Users WITH a CERN computing account register at: http://cern.ch/register/ (CERN Intranet page) Visitors WITHOUT a CERN computing account (e.g. short term visitors) register at: http://cern.ch/regis...

  4. Honorary authorship epidemic in scholarly publications? How the current use of citation-based evaluative metrics make (pseudo)honorary authors from honest contributors of every multi-author article.

    Science.gov (United States)

    Kovacs, Jozsef

    2013-08-01

    The current use of citation-based metrics to evaluate the research output of individual researchers is highly discriminatory because they are uniformly applied to authors of single-author articles as well as contributors of multi-author papers. In the latter case, these quantitative measures are counted, as if each contributor were the single author of the full article. In this way, each and every contributor is assigned the full impact-factor score and all the citations that the article has received. This has a multiplication effect on each contributor's citation-based evaluative metrics of multi-author articles, because the more contributors an article has, the more undeserved credit is assigned to each of them. In this paper, I argue that this unfair system could be made fairer by requesting the contributors of multi-author articles to describe the nature of their contribution, and to assign a numerical value to their degree of relative contribution. In this way, we could create a contribution-specific index of each contributor for each citation metric. This would be a strong disincentive against honorary authorship and publication cartels, because it would transform the current win-win strategy of accepting honorary authors in the byline into a zero-sum game for each contributor.

  5. Registration accuracy and quality of real-life images.

    Directory of Open Access Journals (Sweden)

    Wei-Yen Hsu

    Full Text Available BACKGROUND: A common registration problem for the application of consumer device is to align all the acquired image sequences into a complete scene. Image alignment requires a registration algorithm that will compensate as much as possible for geometric variability among images. However, images captured views from a real scene usually produce different distortions. Some are derived from the optic characteristics of image sensors, and others are caused by the specific scenes and objects. METHODOLOGY/PRINCIPAL FINDINGS: An image registration algorithm considering the perspective projection is proposed for the application of consumer devices in this study. It exploits a multiresolution wavelet-based method to extract significant features. An analytic differential approach is then proposed to achieve fast convergence of point matching. Finally, the registration accuracy is further refined to obtain subpixel precision by a feature-based modified Levenberg-Marquardt method. Due to its feature-based and nonlinear characteristic, it converges considerably faster than most other methods. In addition, vignette compensation and color difference adjustment are also performed to further improve the quality of registration results. CONCLUSIONS/SIGNIFICANCE: The performance of the proposed method is evaluated by testing the synthetic and real images acquired by a hand-held digital still camera and in comparison with two registration techniques in terms of the squared sum of intensity differences (SSD and correlation coefficient (CC. The results indicate that the proposed method is promising in registration accuracy and quality, which are statistically significantly better than other two approaches.

  6. Fast free-form deformable registration via calculus of variations

    International Nuclear Information System (INIS)

    Lu Weiguo; Chen Mingli; Olivera, Gustavo H; Ruchala, Kenneth J; Mackie, Thomas R

    2004-01-01

    In this paper, we present a fully automatic, fast and accurate deformable registration technique. This technique deals with free-form deformation. It minimizes an energy functional that combines both similarity and smoothness measures. By using calculus of variations, the minimization problem was represented as a set of nonlinear elliptic partial differential equations (PDEs). A Gauss-Seidel finite difference scheme is used to iteratively solve the PDE. The registration is refined by a multi-resolution approach. The whole process is fully automatic. It takes less than 3 min to register two three-dimensional (3D) image sets of size 256 x 256 x 61 using a single 933 MHz personal computer. Extensive experiments are presented. These experiments include simulations, phantom studies and clinical image studies. Experimental results show that our model and algorithm are suited for registration of temporal images of a deformable body. The registration of inspiration and expiration phases of the lung images shows that the method is able to deal with large deformations. When applied to the daily CT images of a prostate patient, the results show that registration based on iterative refinement of displacement field is appropriate to describe the local deformations in the prostate and the rectum. Similarity measures improved significantly after the registration. The target application of this paper is for radiotherapy treatment planning and evaluation that incorporates internal organ deformation throughout the course of radiation therapy. The registration method could also be equally applied in diagnostic radiology

  7. Coarse Point Cloud Registration by Egi Matching of Voxel Clusters

    Science.gov (United States)

    Wang, Jinhu; Lindenbergh, Roderik; Shen, Yueqian; Menenti, Massimo

    2016-06-01

    Laser scanning samples the surface geometry of objects efficiently and records versatile information as point clouds. However, often more scans are required to fully cover a scene. Therefore, a registration step is required that transforms the different scans into a common coordinate system. The registration of point clouds is usually conducted in two steps, i.e. coarse registration followed by fine registration. In this study an automatic marker-free coarse registration method for pair-wise scans is presented. First the two input point clouds are re-sampled as voxels and dimensionality features of the voxels are determined by principal component analysis (PCA). Then voxel cells with the same dimensionality are clustered. Next, the Extended Gaussian Image (EGI) descriptor of those voxel clusters are constructed using significant eigenvectors of each voxel in the cluster. Correspondences between clusters in source and target data are obtained according to the similarity between their EGI descriptors. The random sampling consensus (RANSAC) algorithm is employed to remove outlying correspondences until a coarse alignment is obtained. If necessary, a fine registration is performed in a final step. This new method is illustrated on scan data sampling two indoor scenarios. The results of the tests are evaluated by computing the point to point distance between the two input point clouds. The presented two tests resulted in mean distances of 7.6 mm and 9.5 mm respectively, which are adequate for fine registration.

  8. Registration of whole immunohistochemical slide images: an efficient way to characterize biomarker colocalization.

    Science.gov (United States)

    Moles Lopez, Xavier; Barbot, Paul; Van Eycke, Yves-Rémi; Verset, Laurine; Trépant, Anne-Laure; Larbanoix, Lionel; Salmon, Isabelle; Decaestecker, Christine

    2015-01-01

    Extracting accurate information from complex biological processes involved in diseases, such as cancers, requires the simultaneous targeting of multiple proteins and locating their respective expression in tissue samples. This information can be collected by imaging and registering adjacent sections from the same tissue sample and stained by immunohistochemistry (IHC). Registration accuracy should be on the scale of a few cells to enable protein colocalization to be assessed. We propose a simple and efficient method based on the open-source elastix framework to register virtual slides of adjacent sections from the same tissue sample. We characterize registration accuracies for different types of tissue and IHC staining. Our results indicate that this technique is suitable for the evaluation of the colocalization of biomarkers on the scale of a few cells. We also show that using this technique in conjunction with a sequential IHC labeling and erasing technique offers improved registration accuracies. Brightfield IHC enables to address the problem of large series of tissue samples, which are usually required in clinical research. However, this approach, which is simple at the tissue processing level, requires challenging image analysis processes, such as accurate registration, to view and extract the protein colocalization information. The method proposed in this work enables accurate registration (on the scale of a few cells) of virtual slides of adjacent tissue sections on which the expression of different proteins is evidenced by standard IHC. Furthermore, combining our method with a sequential labeling and erasing technique enables cell-scale colocalization. © The Author 2014. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.comFor numbered affiliations see end of article.

  9. Canny edge-based deformable image registration.

    Science.gov (United States)

    Kearney, Vasant; Huang, Yihui; Mao, Weihua; Yuan, Baohong; Tang, Liping

    2017-02-07

    This work focuses on developing a 2D Canny edge-based deformable image registration (Canny DIR) algorithm to register in vivo white light images taken at various time points. This method uses a sparse interpolation deformation algorithm to sparsely register regions of the image with strong edge information. A stability criterion is enforced which removes regions of edges that do not deform in a smooth uniform manner. Using a synthetic mouse surface ground truth model, the accuracy of the Canny DIR algorithm was evaluated under axial rotation in the presence of deformation. The accuracy was also tested using fluorescent dye injections, which were then used for gamma analysis to establish a second ground truth. The results indicate that the Canny DIR algorithm performs better than rigid registration, intensity corrected Demons, and distinctive features for all evaluation matrices and ground truth scenarios. In conclusion Canny DIR performs well in the presence of the unique lighting and shading variations associated with white-light-based image registration.

  10. Hospital Registration Process Reengineering Using Simulation Method

    Directory of Open Access Journals (Sweden)

    Qiang Su

    2010-01-01

    Full Text Available With increasing competition, many healthcare organizations have undergone tremendous reform in the last decade aiming to increase efficiency, decrease waste, and reshape the way that care is delivered. This study focuses on the operational efficiency improvement of hospital’s registration process. The operational efficiency related factors including the service process, queue strategy, and queue parameters were explored systematically and illustrated with a case study. Guided by the principle of business process reengineering (BPR, a simulation approach was employed for process redesign and performance optimization. As a result, the queue strategy is changed from multiple queues and multiple servers to single queue and multiple servers with a prepare queue. Furthermore, through a series of simulation experiments, the length of the prepare queue and the corresponding registration process efficiency was quantitatively evaluated and optimized.

  11. Preliminary design of the database and registration system for the national malignant tumor interventional therapy

    International Nuclear Information System (INIS)

    Hu Di; Zeng Jinjin; Wang Jianfeng; Zhai Renyou

    2010-01-01

    Objective: This research is one of the sub-researches of 'The comparative study of the standards of interventional therapies and the evaluation of the long-term and middle-term effects for common malignant tumors', which is one of the National Key Technologies R and D Program in the eleventh five-year plan. Based on the project,the authors need to establish an international standard in order to set up the national tumor interventional therapy database and registration system. Methods: By using the computing programs of downloading software, self-management and automatic integration, the program was written by the JAVA words. Results: The database and registration system for the national tumor interventional therapy was successfully set up, and it could complete both the simple and complex inquiries. The software worked well through the initial debugging. Conclusion: The national tumor interventional therapy database and registration system can not only precisely tell the popularizing rate of the interventional therapy nationwide, compare the results of different methods, provide the latest news concerning the interventional therapy, subsequently promote the academic exchanges between hospitals, but also help us get the information about the distribution of the interventional physicians, the consuming quantity and variety of the interventional materials, so the medical costs can be reduced. (authors)

  12. Drug Establishments Current Registration Site

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Drug Establishments Current Registration Site (DECRS) is a database of current information submitted by drug firms to register establishments (facilities) which...

  13. Individual Pesticides in Registration Review

    Science.gov (United States)

    You can used the Chemical Search database to search pesticides by chemical name and find their registration review dockets, along with Work Plans, risk assessments, interim and final decisions, tolerance rules, and cancellation actions.

  14. Spherical Demons: Fast Surface Registration

    Science.gov (United States)

    Yeo, B.T. Thomas; Sabuncu, Mert; Vercauteren, Tom; Ayache, Nicholas; Fischl, Bruce; Golland, Polina

    2009-01-01

    We present the fast Spherical Demons algorithm for registering two spherical images. By exploiting spherical vector spline interpolation theory, we show that a large class of regularizers for the modified demons objective function can be efficiently implemented on the sphere using convolution. Based on the one parameter subgroups of diffeomorphisms, the resulting registration is diffeomorphic and fast – registration of two cortical mesh models with more than 100k nodes takes less than 5 minutes, comparable to the fastest surface registration algorithms. Moreover, the accuracy of our method compares favorably to the popular FreeSurfer registration algorithm. We validate the technique in two different settings: (1) parcellation in a set of in-vivo cortical surfaces and (2) Brodmann area localization in ex-vivo cortical surfaces. PMID:18979813

  15. An atlas-based multimodal registration method for 2D images with discrepancy structures.

    Science.gov (United States)

    Lv, Wenchao; Chen, Houjin; Peng, Yahui; Li, Yanfeng; Li, Jupeng

    2018-06-04

    An atlas-based multimodal registration method for 2-dimension images with discrepancy structures was proposed in this paper. Atlas was utilized for complementing the discrepancy structure information in multimodal medical images. The scheme includes three steps: floating image to atlas registration, atlas to reference image registration, and field-based deformation. To evaluate the performance, a frame model, a brain model, and clinical images were employed in registration experiments. We measured the registration performance by the squared sum of intensity differences. Results indicate that this method is robust and performs better than the direct registration for multimodal images with discrepancy structures. We conclude that the proposed method is suitable for multimodal images with discrepancy structures. Graphical Abstract An Atlas-based multimodal registration method schematic diagram.

  16. A national multicenter registration study. Omalizumb in children in Denmark

    DEFF Research Database (Denmark)

    Spangberg, Katrien; Jørgensen, Inger Merete; Agertoft, Lone

    Background: In Denmark, Omalizumab is approved to treat children with severe persistent allergic asthma older than 6 years of age. No systematic registration of the efficacy in the Danish child population according to asthma symptoms or of the efficacy on co-morbid allergic symptoms exists. Results...... from a pilot study show that a broad panel of outcome measures is necessary to evaluate the efficacy of Omalizumab treatment as no change in lung function could be demonstrated Aim: To provide a standardized systematic registration in order to create a database enrolling children with severe allergic...... asthma treated with Omalizumab. Method and study design: A national multicenter registration and follow-up study based on children with clinical persistent severe allergic asthma including both retrospective and prospective registration. Inclusion criteria: • 6-18 years of age. • Severe persistent...

  17. Gaussian Process Interpolation for Uncertainty Estimation in Image Registration

    Science.gov (United States)

    Wachinger, Christian; Golland, Polina; Reuter, Martin; Wells, William

    2014-01-01

    Intensity-based image registration requires resampling images on a common grid to evaluate the similarity function. The uncertainty of interpolation varies across the image, depending on the location of resampled points relative to the base grid. We propose to perform Bayesian inference with Gaussian processes, where the covariance matrix of the Gaussian process posterior distribution estimates the uncertainty in interpolation. The Gaussian process replaces a single image with a distribution over images that we integrate into a generative model for registration. Marginalization over resampled images leads to a new similarity measure that includes the uncertainty of the interpolation. We demonstrate that our approach increases the registration accuracy and propose an efficient approximation scheme that enables seamless integration with existing registration methods. PMID:25333127

  18. Groupwise registration of MR brain images with tumors

    Science.gov (United States)

    Tang, Zhenyu; Wu, Yihong; Fan, Yong

    2017-09-01

    A novel groupwise image registration framework is developed for registering MR brain images with tumors. Our method iteratively estimates a normal-appearance counterpart for each tumor image to be registered and constructs a directed graph (digraph) of normal-appearance images to guide the groupwise image registration. Particularly, our method maps each tumor image to its normal appearance counterpart by identifying and inpainting brain tumor regions with intensity information estimated using a low-rank plus sparse matrix decomposition based image representation technique. The estimated normal-appearance images are groupwisely registered to a group center image guided by a digraph of images so that the total length of ‘image registration paths’ to be the minimum, and then the original tumor images are warped to the group center image using the resulting deformation fields. We have evaluated our method based on both simulated and real MR brain tumor images. The registration results were evaluated with overlap measures of corresponding brain regions and average entropy of image intensity information, and Wilcoxon signed rank tests were adopted to compare different methods with respect to their regional overlap measures. Compared with a groupwise image registration method that is applied to normal-appearance images estimated using the traditional low-rank plus sparse matrix decomposition based image inpainting, our method achieved higher image registration accuracy with statistical significance (p  =  7.02  ×  10-9).

  19. A Remote Registration Based on MIDAS

    Science.gov (United States)

    JIN, Xin

    2017-04-01

    We often need for software registration to protect the interests of the software developers. This article narrated one kind of software long-distance registration technology. The registration method is: place the registration information in a database table, after the procedure starts in check table registration information, if it has registered then the procedure may the normal operation; Otherwise, the customer must input the sequence number and registers through the network on the long-distance server. If it registers successfully, then records the registration information in the database table. This remote registration method can protect the rights of software developers.

  20. 3-D brain image registration using optimal morphological processing

    International Nuclear Information System (INIS)

    Loncaric, S.; Dhawan, A.P.

    1994-01-01

    The three-dimensional (3-D) registration of Magnetic Resonance (MR) and Positron Emission Tomographic (PET) images of the brain is important for analysis of the human brain and its diseases. A procedure for optimization of (3-D) morphological structuring elements, based on a genetic algorithm, is presented in the paper. The registration of the MR and PET images is done by means of a registration procedure in two major phases. In the first phase, the Iterative Principal Axis Transform (IPAR) is used for initial registration. In the second phase, the optimal shape description method based on the Morphological Signature Transform (MST) is used for final registration. The morphological processing is used to improve the accuracy of the basic IPAR method. The brain ventricle is used as a landmark for MST registration. A near-optimal structuring element obtained by means of a genetic algorithm is used in MST to describe the shape of the ventricle. The method has been tested on the set of brain images demonstrating the feasibility of approach. (author). 11 refs., 3 figs

  1. Feasibility of Multimodal Deformable Registration for Head and Neck Tumor Treatment Planning

    Energy Technology Data Exchange (ETDEWEB)

    Fortunati, Valerio, E-mail: v.fortunati@erasmusmc.nl [Biomedical Imaging Group Rotterdam, Department of Medical Informatics and Radiology, Erasmus MC University Medical Center, Rotterdam (Netherlands); Verhaart, René F. [Hyperthermia Unit, Department of Radiation Oncology, Erasmus MC University Medical Center Cancer Institute, Rotterdam (Netherlands); Angeloni, Francesco [Istituto di Ricovero e Cura a Carattere Scientifico Foundation SDN for Research and High Education in Nuclear Diagnostics, Naples (Italy); Lugt, Aad van der [Department of Radiology, Erasmus MC University Medical Center, Rotterdam (Netherlands); Niessen, Wiro J. [Biomedical Imaging Group Rotterdam, Department of Medical Informatics and Radiology, Erasmus MC University Medical Center, Rotterdam (Netherlands); Faculty of Applied Sciences, Delft University of Technology, Delft (Netherlands); Veenland, Jifke F. [Biomedical Imaging Group Rotterdam, Department of Medical Informatics and Radiology, Erasmus MC University Medical Center, Rotterdam (Netherlands); Paulides, Margarethus M. [Hyperthermia Unit, Department of Radiation Oncology, Erasmus MC University Medical Center Cancer Institute, Rotterdam (Netherlands); Walsum, Theo van [Biomedical Imaging Group Rotterdam, Department of Medical Informatics and Radiology, Erasmus MC University Medical Center, Rotterdam (Netherlands)

    2014-09-01

    Purpose: To investigate the feasibility of using deformable registration in clinical practice to fuse MR and CT images of the head and neck for treatment planning. Method and Materials: A state-of-the-art deformable registration algorithm was optimized, evaluated, and compared with rigid registration. The evaluation was based on manually annotated anatomic landmarks and regions of interest in both modalities. We also developed a multiparametric registration approach, which simultaneously aligns T1- and T2-weighted MR sequences to CT. This was evaluated and compared with single-parametric approaches. Results: Our results show that deformable registration yielded a better accuracy than rigid registration, without introducing unrealistic deformations. For deformable registration, an average landmark alignment of approximatively 1.7 mm was obtained. For all the regions of interest excluding the cerebellum and the parotids, deformable registration provided a median modified Hausdorff distance of approximatively 1 mm. Similar accuracies were obtained for the single-parameter and multiparameter approaches. Conclusions: This study demonstrates that deformable registration of head-and-neck CT and MR images is feasible, with overall a significanlty higher accuracy than for rigid registration.

  2. Feasibility of Multimodal Deformable Registration for Head and Neck Tumor Treatment Planning

    International Nuclear Information System (INIS)

    Fortunati, Valerio; Verhaart, René F.; Angeloni, Francesco; Lugt, Aad van der; Niessen, Wiro J.; Veenland, Jifke F.; Paulides, Margarethus M.; Walsum, Theo van

    2014-01-01

    Purpose: To investigate the feasibility of using deformable registration in clinical practice to fuse MR and CT images of the head and neck for treatment planning. Method and Materials: A state-of-the-art deformable registration algorithm was optimized, evaluated, and compared with rigid registration. The evaluation was based on manually annotated anatomic landmarks and regions of interest in both modalities. We also developed a multiparametric registration approach, which simultaneously aligns T1- and T2-weighted MR sequences to CT. This was evaluated and compared with single-parametric approaches. Results: Our results show that deformable registration yielded a better accuracy than rigid registration, without introducing unrealistic deformations. For deformable registration, an average landmark alignment of approximatively 1.7 mm was obtained. For all the regions of interest excluding the cerebellum and the parotids, deformable registration provided a median modified Hausdorff distance of approximatively 1 mm. Similar accuracies were obtained for the single-parameter and multiparameter approaches. Conclusions: This study demonstrates that deformable registration of head-and-neck CT and MR images is feasible, with overall a significanlty higher accuracy than for rigid registration

  3. Automated landmark-guided deformable image registration.

    Science.gov (United States)

    Kearney, Vasant; Chen, Susie; Gu, Xuejun; Chiu, Tsuicheng; Liu, Honghuan; Jiang, Lan; Wang, Jing; Yordy, John; Nedzi, Lucien; Mao, Weihua

    2015-01-07

    The purpose of this work is to develop an automated landmark-guided deformable image registration (LDIR) algorithm between the planning CT and daily cone-beam CT (CBCT) with low image quality. This method uses an automated landmark generation algorithm in conjunction with a local small volume gradient matching search engine to map corresponding landmarks between the CBCT and the planning CT. The landmarks act as stabilizing control points in the following Demons deformable image registration. LDIR is implemented on graphics processing units (GPUs) for parallel computation to achieve ultra fast calculation. The accuracy of the LDIR algorithm has been evaluated on a synthetic case in the presence of different noise levels and data of six head and neck cancer patients. The results indicate that LDIR performed better than rigid registration, Demons, and intensity corrected Demons for all similarity metrics used. In conclusion, LDIR achieves high accuracy in the presence of multimodality intensity mismatch and CBCT noise contamination, while simultaneously preserving high computational efficiency.

  4. Mammogram CAD, hybrid registration and iconic analysis

    Science.gov (United States)

    Boucher, A.; Cloppet, F.; Vincent, N.

    2013-03-01

    This paper aims to develop a computer aided diagnosis (CAD) based on a two-step methodology to register and analyze pairs of temporal mammograms. The concept of "medical file", including all the previous medical information on a patient, enables joint analysis of different acquisitions taken at different times, and the detection of significant modifications. The developed registration method aims to superimpose at best the different anatomical structures of the breast. The registration is designed in order to get rid of deformation undergone by the acquisition process while preserving those due to breast changes indicative of malignancy. In order to reach this goal, a referent image is computed from control points based on anatomical features that are extracted automatically. Then the second image of the couple is realigned on the referent image, using a coarse-to-fine approach according to expert knowledge that allows both rigid and non-rigid transforms. The joint analysis detects the evolution between two images representing the same scene. In order to achieve this, it is important to know the registration error limits in order to adapt the observation scale. The approach used in this paper is based on an image sparse representation. Decomposed in regular patterns, the images are analyzed under a new angle. The evolution detection problem has many practical applications, especially in medical images. The CAD is evaluated using recall and precision of differences in mammograms.

  5. Automated landmark-guided deformable image registration

    International Nuclear Information System (INIS)

    Kearney, Vasant; Chen, Susie; Gu, Xuejun; Chiu, Tsuicheng; Liu, Honghuan; Jiang, Lan; Wang, Jing; Yordy, John; Nedzi, Lucien; Mao, Weihua

    2015-01-01

    The purpose of this work is to develop an automated landmark-guided deformable image registration (LDIR) algorithm between the planning CT and daily cone-beam CT (CBCT) with low image quality. This method uses an automated landmark generation algorithm in conjunction with a local small volume gradient matching search engine to map corresponding landmarks between the CBCT and the planning CT. The landmarks act as stabilizing control points in the following Demons deformable image registration. LDIR is implemented on graphics processing units (GPUs) for parallel computation to achieve ultra fast calculation. The accuracy of the LDIR algorithm has been evaluated on a synthetic case in the presence of different noise levels and data of six head and neck cancer patients. The results indicate that LDIR performed better than rigid registration, Demons, and intensity corrected Demons for all similarity metrics used. In conclusion, LDIR achieves high accuracy in the presence of multimodality intensity mismatch and CBCT noise contamination, while simultaneously preserving high computational efficiency. (paper)

  6. Evaluation of Existing Structure and Civil Protection Management Framework in Greek Local Authorities: A Questionnaire Survey Demonstrates Why Prevention Fails

    Science.gov (United States)

    Papanikolaou, Dimitrios; Papanikolaou, Ioannis; Diakakis, Michalis; Deligiannakis, Georgios

    2013-04-01

    In the face of a growing number of natural disasters and the increasing costs associated with them, Europe and Greece in particular, have devoted significant efforts and resources in natural hazards mitigation during the last decades. Despite the significant legislative efforts (e.g. 1998/22/EC, 2001/792/EC, 2007/60/EC Directives, 3013/2002 Act) and even though a number of steps has been taken towards improving civil protection, recent catastrophic events have illustrated the weaknesses of current approaches. In particular, in Greece, events such as the 1999 Athens earthquake, the 2007 and 2009 wildfires have shown the inadequacy of prevention and mitigation practices. Given the enhanced civil protection responsibilities, given by the Greek national law (Acts 3013/2002, 3852/2010) to local authorities in Greece, this work analyses and evaluates the existing structure and current management framework under which local authorities function and examines their risk mitigation practices. We conducted the largest questionnaire survey regarding Civil Protections issues, among the municipalities of Greece. To this aim, this work used a innovative online tool to assess current framework. Therefore, a network connecting civil protection departments of municipalities was developed, based on an Internet platform that acted also as a communication tool. Overall, we had feedback either online or offline from 125 municipalities across the country (representing more than one/third of the total municipalities of Greece). Through this network, municipal civil protection officials completed surveys designed to obtain and quantify information on several aspects of civil protection practices and infrastructure. In particular, the examined factors included: (i) personnel and equipment, (ii) inter-agency cooperation, (iii) training, (iv) compliance with existing regulations and (v) persistent problems encountered by civil protection departments, that prevent the effectiveness of current

  7. Automated registration of multispectral MR vessel wall images of the carotid artery

    Energy Technology Data Exchange (ETDEWEB)

    Klooster, R. van ' t; Staring, M.; Reiber, J. H. C.; Lelieveldt, B. P. F.; Geest, R. J. van der, E-mail: rvdgeest@lumc.nl [Department of Radiology, Division of Image Processing, Leiden University Medical Center, 2300 RC Leiden (Netherlands); Klein, S. [Department of Radiology and Department of Medical Informatics, Biomedical Imaging Group Rotterdam, Erasmus MC, Rotterdam 3015 GE (Netherlands); Kwee, R. M.; Kooi, M. E. [Department of Radiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht 6202 AZ (Netherlands)

    2013-12-15

    Purpose: Atherosclerosis is the primary cause of heart disease and stroke. The detailed assessment of atherosclerosis of the carotid artery requires high resolution imaging of the vessel wall using multiple MR sequences with different contrast weightings. These images allow manual or automated classification of plaque components inside the vessel wall. Automated classification requires all sequences to be in alignment, which is hampered by patient motion. In clinical practice, correction of this motion is performed manually. Previous studies applied automated image registration to correct for motion using only nondeformable transformation models and did not perform a detailed quantitative validation. The purpose of this study is to develop an automated accurate 3D registration method, and to extensively validate this method on a large set of patient data. In addition, the authors quantified patient motion during scanning to investigate the need for correction. Methods: MR imaging studies (1.5T, dedicated carotid surface coil, Philips) from 55 TIA/stroke patients with ipsilateral <70% carotid artery stenosis were randomly selected from a larger cohort. Five MR pulse sequences were acquired around the carotid bifurcation, each containing nine transverse slices: T1-weighted turbo field echo, time of flight, T2-weighted turbo spin-echo, and pre- and postcontrast T1-weighted turbo spin-echo images (T1W TSE). The images were manually segmented by delineating the lumen contour in each vessel wall sequence and were manually aligned by applying throughplane and inplane translations to the images. To find the optimal automatic image registration method, different masks, choice of the fixed image, different types of the mutual information image similarity metric, and transformation models including 3D deformable transformation models, were evaluated. Evaluation of the automatic registration results was performed by comparing the lumen segmentations of the fixed image and

  8. Automated registration of multispectral MR vessel wall images of the carotid artery

    International Nuclear Information System (INIS)

    Klooster, R. van 't; Staring, M.; Reiber, J. H. C.; Lelieveldt, B. P. F.; Geest, R. J. van der; Klein, S.; Kwee, R. M.; Kooi, M. E.

    2013-01-01

    Purpose: Atherosclerosis is the primary cause of heart disease and stroke. The detailed assessment of atherosclerosis of the carotid artery requires high resolution imaging of the vessel wall using multiple MR sequences with different contrast weightings. These images allow manual or automated classification of plaque components inside the vessel wall. Automated classification requires all sequences to be in alignment, which is hampered by patient motion. In clinical practice, correction of this motion is performed manually. Previous studies applied automated image registration to correct for motion using only nondeformable transformation models and did not perform a detailed quantitative validation. The purpose of this study is to develop an automated accurate 3D registration method, and to extensively validate this method on a large set of patient data. In addition, the authors quantified patient motion during scanning to investigate the need for correction. Methods: MR imaging studies (1.5T, dedicated carotid surface coil, Philips) from 55 TIA/stroke patients with ipsilateral <70% carotid artery stenosis were randomly selected from a larger cohort. Five MR pulse sequences were acquired around the carotid bifurcation, each containing nine transverse slices: T1-weighted turbo field echo, time of flight, T2-weighted turbo spin-echo, and pre- and postcontrast T1-weighted turbo spin-echo images (T1W TSE). The images were manually segmented by delineating the lumen contour in each vessel wall sequence and were manually aligned by applying throughplane and inplane translations to the images. To find the optimal automatic image registration method, different masks, choice of the fixed image, different types of the mutual information image similarity metric, and transformation models including 3D deformable transformation models, were evaluated. Evaluation of the automatic registration results was performed by comparing the lumen segmentations of the fixed image and

  9. A prospective comparison between auto-registration and manual registration of real-time ultrasound with MR images for percutaneous ablation or biopsy of hepatic lesions.

    Science.gov (United States)

    Cha, Dong Ik; Lee, Min Woo; Song, Kyoung Doo; Oh, Young-Taek; Jeong, Ja-Yeon; Chang, Jung-Woo; Ryu, Jiwon; Lee, Kyong Joon; Kim, Jaeil; Bang, Won-Chul; Shin, Dong Kuk; Choi, Sung Jin; Koh, Dalkwon; Seo, Bong Koo; Kim, Kyunga

    2017-06-01

    To compare the accuracy and required time for image fusion of real-time ultrasound (US) with pre-procedural magnetic resonance (MR) images between positioning auto-registration and manual registration for percutaneous radiofrequency ablation or biopsy of hepatic lesions. This prospective study was approved by the institutional review board, and all patients gave written informed consent. Twenty-two patients (male/female, n = 18/n = 4; age, 61.0 ± 7.7 years) who were referred for planning US to assess the feasibility of radiofrequency ablation (n = 21) or biopsy (n = 1) for focal hepatic lesions were included. One experienced radiologist performed the two types of image fusion methods in each patient. The performance of auto-registration and manual registration was evaluated. The accuracy of the two methods, based on measuring registration error, and the time required for image fusion for both methods were recorded using in-house software and respectively compared using the Wilcoxon signed rank test. Image fusion was successful in all patients. The registration error was not significantly different between the two methods (auto-registration: median, 3.75 mm; range, 1.0-15.8 mm vs. manual registration: median, 2.95 mm; range, 1.2-12.5 mm, p = 0.242). The time required for image fusion was significantly shorter with auto-registration than with manual registration (median, 28.5 s; range, 18-47 s, vs. median, 36.5 s; range, 14-105 s, p = 0.026). Positioning auto-registration showed promising results compared with manual registration, with similar accuracy and even shorter registration time.

  10. Why and how to make a REACH registration of combustion ash; Moejligheter vid REACH-registrering av energiaskor

    Energy Technology Data Exchange (ETDEWEB)

    Loevgren, Linnea; Wik, Ola

    2009-10-15

    The new chemical regulation, REACH (1997/2006/EC), Registration, Evaluation, Authorization and restriction of Chemicals, took effect the 1st of June 2007. The background to this report was the introduction of REACH and the difficulties to understand the implications for ash. The most important consequence of REACH is that all chemical substances that are manufactured, handled and used above one tonne per annum per legal entity shall be registered according to this regulation. The registration includes specifying the chemical, physical, toxicity and ecotoxicity properties of the substance and risk assessing the identified areas of use. The report describes the use of ash in connection to the waste legislation and its planned end-of-waste-criteria, the chemical legislation and the Construction Products Directive. The target audience of this report is companies producing ashes and having a use or seeing a use for its ash. The report describes how to make a REACH registration of ash independent if a company did or did not pre-register ash during 2008. It describes how to change from one ash registration into another if the pre-registration was done for one type of ash but the company changes opinion during the sameness check, i.e. changing SIEF (Appendix A). Taking part in REACH registration projects during 2009-2010 can be advantageous since knowledge and financing are shared. Ash can be REACH registered also in the future but it is important to know that the registration have to be done prior the production and marketing starts. If ash is consider to be a waste the handling is covered by the community and national waste legislation. In Sweden ashes are by and large being regarded as waste, and recycling is risk assessed and permits are given case by case. End-of-waste criteria for different waste material are being elaborated within the EU. Such criteria will among other details cover chemical safety. When a material fulfils the end-of-waste criteria such material

  11. Medical image registration for analysis

    International Nuclear Information System (INIS)

    Petrovic, V.

    2006-01-01

    Full text: Image registration techniques represent a rich family of image processing and analysis tools that aim to provide spatial correspondences across sets of medical images of similar and disparate anatomies and modalities. Image registration is a fundamental and usually the first step in medical image analysis and this paper presents a number of advanced techniques as well as demonstrates some of the advanced medical image analysis techniques they make possible. A number of both rigid and non-rigid medical image alignment algorithms of equivalent and merely consistent anatomical structures respectively are presented. The algorithms are compared in terms of their practical aims, inputs, computational complexity and level of operator (e.g. diagnostician) interaction. In particular, the focus of the methods discussion is placed on the applications and practical benefits of medical image registration. Results of medical image registration on a number of different imaging modalities and anatomies are presented demonstrating the accuracy and robustness of their application. Medical image registration is quickly becoming ubiquitous in medical imaging departments with the results of such algorithms increasingly used in complex medical image analysis and diagnostics. This paper aims to demonstrate at least part of the reason why

  12. A systematic review of comparisons between protocols or registrations and full reports in primary biomedical research

    Directory of Open Access Journals (Sweden)

    Guowei Li

    2018-01-01

    registrations and full reports of primary biomedical research is frequent, prevalent and suboptimal. We also identified methodological issues such as the need for consensus on measuring inconsistency across sources for trial reports, and more studies evaluating transparency and reproducibility in reporting all aspects of study design and analysis. A joint effort involving authors, journals, sponsors, regulators and research ethics committees is required to solve this problem.

  13. Behaviors study of image registration algorithms in image guided radiation therapy

    International Nuclear Information System (INIS)

    Zou Lian; Hou Qing

    2008-01-01

    Objective: Study the behaviors of image registration algorithms, and analyze the elements which influence the performance of image registrations. Methods: Pre-known corresponding coordinates were appointed for reference image and moving image, and then the influence of region of interest (ROI) selection, transformation function initial parameters and coupled parameter spaces on registration results were studied with a software platform developed in home. Results: Region of interest selection had a manifest influence on registration performance. An improperly chosen ROI resulted in a bad registration. Transformation function initial parameters selection based on pre-known information could improve the accuracy of image registration. Coupled parameter spaces would enhance the dependence of image registration algorithm on ROI selection. Conclusions: It is necessary for clinic IGRT to obtain a ROI selection strategy (depending on specific commercial software) correlated to tumor sites. Three suggestions for image registration technique developers are automatic selection of the initial parameters of transformation function based on pre-known information, developing specific image registration algorithm for specific image feature, and assembling real-time image registration algorithms according to tumor sites selected by software user. (authors)

  14. 78 FR 64019 - Manufacturer of Controlled Substances, Notice of Registration, Austin Pharma, LLC.

    Science.gov (United States)

    2013-10-25

    ..., Notice of Registration, Austin Pharma, LLC. By Notice dated May 14, 2013, and published in the Federal Register on May 22, 2013, 78 FR 30332, Austin Pharma, LLC., 811 Paloma Drive, Suite C, Round Rock, Texas... this drug code is authorized for this registration. On August 9, 2013, Austin Pharma, LLC., withdrew...

  15. Less is More : Better Compliance and Increased Revenues by Streamlining Business Registration in Uganda

    OpenAIRE

    Sander, Cerstin

    2003-01-01

    A pilot of a streamlined business registration system in Entebbe, Uganda, reduced compliance costs for enterprises by 75 percent, raised registration numbers and fee revenue by 40 percent and reduced the cost of administering the system. It also reduced opportunities for corruption, improved relations between businesses and the local authorities and resulted in better compliance.

  16. Registration concepts for the just-in-time artefact correction by means of virtual computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kasperl, St.; Franz, M. [Fraunhofer Development Center for X-ray Technology EZRT, a cooperative dept. of the Fraunhofer Institutes IZFP Saarbrucken and IIS Erlangen, Furth (Germany)

    2007-07-01

    This article deals with the enhancement of accuracy in CT by just-in-time correction of artefacts (beam hardening, scattered radiation) caused by the interaction of X-rays with matter. The so called EAR method needs for simulation a registration of the object. Therefore the article presents two different registration concepts. (authors)

  17. Registration concepts for the just-in-time artefact correction by means of virtual computed tomography

    International Nuclear Information System (INIS)

    Kasperl, St.; Franz, M.

    2007-01-01

    This article deals with the enhancement of accuracy in CT by just-in-time correction of artefacts (beam hardening, scattered radiation) caused by the interaction of X-rays with matter. The so called EAR method needs for simulation a registration of the object. Therefore the article presents two different registration concepts. (authors)

  18. 17 CFR 240.15b6-1 - Withdrawal from registration.

    Science.gov (United States)

    2010-04-01

    ... Registration Depository (operated by the Financial Industry Regulatory Authority, Inc.) in accordance with...) to update any inaccurate information. (b) A notice of withdrawal from registration filed by a broker... public interest or for the protection of investors, or within such shorter period of time as the...

  19. Population based ranking of frameless CT-MRI registration methods

    Energy Technology Data Exchange (ETDEWEB)

    Opposits, Gabor; Kis, Sandor A.; Tron, Lajos; Emri, Miklos [Debrecen Univ. (Hungary). Dept. of Nuclear Medicine; Berenyi, Ervin [Debrecen Univ. (Hungary). Dept. of Biomedical Laboratory and Imaging Science; Takacs, Endre [Rotating Gamma Ltd., Debrecen (Hungary); Dobai, Jozsef G.; Bognar, Laszlo [Debrecen Univ., Medical Center (Hungary). Dept. of Neurosurgery; Szuecs, Bernadett [ScanoMed Ltd., Debrecen (Hungary)

    2015-07-01

    Clinical practice often requires simultaneous information obtained by two different imaging modalities. Registration algorithms are commonly used for this purpose. Automated procedures are very helpful in cases when the same kind of registration has to be performed on images of a high number of subjects. Radiotherapists would prefer to use the best automated method to assist therapy planning, however there are not accepted procedures for ranking the different registration algorithms. We were interested in developing a method to measure the population level performance of CT-MRI registration algorithms by a parameter of values in the [0,1] interval. Pairs of CT and MRI images were collected from 1051 subjects. Results of an automated registration were corrected manually until a radiologist and a neurosurgeon expert both accepted the result as good. This way 1051 registered MRI images were produced by the same pair of experts to be used as gold standards for the evaluation of the performance of other registration algorithms. Pearson correlation coefficient, mutual information, normalized mutual information, Kullback-Leibler divergence, L{sub 1} norm and square L{sub 2} norm (dis)similarity measures were tested for sensitivity to indicate the extent of (dis)similarity of a pair of individual mismatched images. The square Hellinger distance proved suitable to grade the performance of registration algorithms at population level providing the developers with a valuable tool to rank algorithms. The developed procedure provides an objective method to find the registration algorithm performing the best on the population level out of newly constructed or available preselected ones.

  20. Automatic intra-modality brain image registration method

    International Nuclear Information System (INIS)

    Whitaker, J.M.; Ardekani, B.A.; Braun, M.

    1996-01-01

    Full text: Registration of 3D images of brain of the same or different subjects has potential importance in clinical diagnosis, treatment planning and neurological research. The broad aim of our work is to produce an automatic and robust intra-modality, brain image registration algorithm for intra-subject and inter-subject studies. Our algorithm is composed of two stages. Initial alignment is achieved by finding the values of nine transformation parameters (representing translation, rotation and scale) that minimise the nonoverlapping regions of the head. This is achieved by minimisation of the sum of the exclusive OR of two binary head images, produced using the head extraction procedure described by Ardekani et al. (J Comput Assist Tomogr, 19:613-623, 1995). The initial alignment successfully determines the scale parameters and gross translation and rotation parameters. Fine alignment uses an objective function described for inter-modality registration in Ardekani et al. (ibid.). The algorithm segments one of the images to be aligned into a set of connected components using K-means clustering. Registration is achieved by minimising the K-means variance of the segmentation induced in the other image. Similarity of images of the same modality makes the method attractive for intra-modality registration. A 3D MR image, with voxel dimensions, 2x2x6 mm, was misaligned. The registered image shows visually accurate registration. The average displacement of a pixel from its correct location was measured to be 3.3 mm. The algorithm was tested on intra-subject MR images and was found to produce good qualitative results. Using the data available, the algorithm produced promising qualitative results in intra-subject registration. Further work is necessary in its application to intersubject registration, due to large variability in brain structure between subjects. Clinical evaluation of the algorithm for selected applications is required

  1. Registration of radiation doses

    International Nuclear Information System (INIS)

    2000-02-01

    In Finland the Radiation and Nuclear Safety Authority (STUK) is maintaining the register (called Dose Register) of the radiation exposure of occupationally exposed workers in order to ensure compliance with the principles of optimisation and individual protection. The guide contains a description of the Dose Register and specifies the responsibilities of the party running a radiation practice to report the relevant information to the Dose Register

  2. Language proficiency and nursing registration.

    Science.gov (United States)

    Müller, Amanda

    2016-02-01

    This discussion paper focuses on English proficiency standards for nursing registration in Australia, how Australia has dealt with the issue of language proficiency, and the factors which have led to the establishment of the current language standards. Also, this paper will provide a comparison of the two language tests that are currently accepted in Australia (OET and IELTS), including the appropriateness of these tests and the minimum standards used. The paper will also examine the use of educational background as an indicator of language proficiency. Finally, communication-based complaints in the post-registration environment will be explored, and some discussion will be provided about why pre-registration measures might have failed to prevent such problematic situations from occurring. Copyright © 2015 Elsevier Ltd. All rights reserved.

  3. 3D/3D registration of coronary CTA and biplane XA reconstructions for improved image guidance

    Energy Technology Data Exchange (ETDEWEB)

    Dibildox, Gerardo, E-mail: g.dibildox@erasmusmc.nl; Baka, Nora; Walsum, Theo van [Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus Medical Center, 3015 GE Rotterdam (Netherlands); Punt, Mark; Aben, Jean-Paul [Pie Medical Imaging, 6227 AJ Maastricht (Netherlands); Schultz, Carl [Department of Cardiology, Erasmus Medical Center, 3015 GE Rotterdam (Netherlands); Niessen, Wiro [Quantitative Imaging Group, Faculty of Applied Sciences, Delft University of Technology, 2628 CJ Delft, The Netherlands and Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus Medical Center, 3015 GE Rotterdam (Netherlands)

    2014-09-15

    Purpose: The authors aim to improve image guidance during percutaneous coronary interventions of chronic total occlusions (CTO) by providing information obtained from computed tomography angiography (CTA) to the cardiac interventionist. To this end, the authors investigate a method to register a 3D CTA model to biplane reconstructions. Methods: The authors developed a method for registering preoperative coronary CTA with intraoperative biplane x-ray angiography (XA) images via 3D models of the coronary arteries. The models are extracted from the CTA and biplane XA images, and are temporally aligned based on CTA reconstruction phase and XA ECG signals. Rigid spatial alignment is achieved with a robust probabilistic point set registration approach using Gaussian mixture models (GMMs). This approach is extended by including orientation in the Gaussian mixtures and by weighting bifurcation points. The method is evaluated on retrospectively acquired coronary CTA datasets of 23 CTO patients for which biplane XA images are available. Results: The Gaussian mixture model approach achieved a median registration accuracy of 1.7 mm. The extended GMM approach including orientation was not significantly different (P > 0.1) but did improve robustness with regards to the initialization of the 3D models. Conclusions: The authors demonstrated that the GMM approach can effectively be applied to register CTA to biplane XA images for the purpose of improving image guidance in percutaneous coronary interventions.

  4. 77 FR 18705 - Discontinuance of Form CO in Registration Practices

    Science.gov (United States)

    2012-03-28

    ... issue, the author is a citizen or domiciliary of the United States, the work is a work for hire, the... LIBRARY OF CONGRESS Copyright Office 37 CFR Parts 201 and 202 [Docket No. 2011-8] Discontinuance of Form CO in Registration Practices AGENCY: Copyright Office, Library of Congress. ACTION: Final...

  5. Mass Preserving Registration for lung CT

    DEFF Research Database (Denmark)

    Gorbunova, Vladlena; Lo, Pechin Chien Pau; Loeve, Martin

    2009-01-01

    intensities due to differences in inspiration level, we propose to adjust the intensity of lung tissue according to the local expansion or compression. An image registration method without intensity adjustment is compared to the proposed method. Both approaches are evaluated on a set of 10 pairs of expiration...... and inspiration CT scans of children with cystic fibrosis lung disease. The proposed method with mass preserving adjustment results in significantly better alignment of the vessel trees. Analysis of local volume change for regions with trapped air compared to normally ventilated regions revealed larger...

  6. Interindividual registration and dose mapping for voxelwise population analysis of rectal toxicity in prostate cancer radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Dréan, Gaël; Acosta, Oscar, E-mail: Oscar.Acosta@univ-rennes1.fr; Simon, Antoine; Haigron, Pascal [INSERM, U1099, Rennes F-35000 (France); Université de Rennes 1, LTSI, Rennes F-35000 (France); Lafond, Caroline; Crevoisier, Renaud de [INSERM, U1099, Rennes F-35000 (France); Université de Rennes 1, LTSI, Rennes F-35000 (France); Département de Radiothérapie, Center Eugène Marquis, Rennes F-35000 (France)

    2016-06-15

    Purpose: Recent studies revealed a trend toward voxelwise population analysis in order to understand the local dose/toxicity relationships in prostate cancer radiotherapy. Such approaches require, however, an accurate interindividual mapping of the anatomies and 3D dose distributions toward a common coordinate system. This step is challenging due to the high interindividual variability. In this paper, the authors propose a method designed for interindividual nonrigid registration of the rectum and dose mapping for population analysis. Methods: The method is based on the computation of a normalized structural description of the rectum using a Laplacian-based model. This description takes advantage of the tubular structure of the rectum and its centerline to be embedded in a nonrigid registration-based scheme. The performances of the method were evaluated on 30 individuals treated for prostate cancer in a leave-one-out cross validation. Results: Performance was measured using classical metrics (Dice score and Hausdorff distance), along with new metrics devised to better assess dose mapping in relation with structural deformation (dose-organ overlap). Considering these scores, the proposed method outperforms intensity-based and distance maps-based registration methods. Conclusions: The proposed method allows for accurately mapping interindividual 3D dose distributions toward a single anatomical template, opening the way for further voxelwise statistical analysis.

  7. Technical Note: DIRART- A software suite for deformable image registration and adaptive radiotherapy research

    International Nuclear Information System (INIS)

    Yang Deshan; Brame, Scott; El Naqa, Issam; Aditya, Apte; Wu Yu; Murty Goddu, S.; Mutic, Sasa; Deasy, Joseph O.; Low, Daniel A.

    2011-01-01

    Purpose: Recent years have witnessed tremendous progress in image guide radiotherapy technology and a growing interest in the possibilities for adapting treatment planning and delivery over the course of treatment. One obstacle faced by the research community has been the lack of a comprehensive open-source software toolkit dedicated for adaptive radiotherapy (ART). To address this need, the authors have developed a software suite called the Deformable Image Registration and Adaptive Radiotherapy Toolkit (DIRART). Methods: DIRART is an open-source toolkit developed in MATLAB. It is designed in an object-oriented style with focus on user-friendliness, features, and flexibility. It contains four classes of DIR algorithms, including the newer inverse consistency algorithms to provide consistent displacement vector field in both directions. It also contains common ART functions, an integrated graphical user interface, a variety of visualization and image-processing features, dose metric analysis functions, and interface routines. These interface routines make DIRART a powerful complement to the Computational Environment for Radiotherapy Research (CERR) and popular image-processing toolkits such as ITK. Results: DIRART provides a set of image processing/registration algorithms and postprocessing functions to facilitate the development and testing of DIR algorithms. It also offers a good amount of options for DIR results visualization, evaluation, and validation. Conclusions: By exchanging data with treatment planning systems via DICOM-RT files and CERR, and by bringing image registration algorithms closer to radiotherapy applications, DIRART is potentially a convenient and flexible platform that may facilitate ART and DIR research.

  8. A three-dimensional correlation method for registration of medical images in radiology

    International Nuclear Information System (INIS)

    Georgiou, Michalakis; Sfakianakis, George N.; Nagel, Joachim H.

    1998-01-01

    The availability of methods to register multi-modality images in order to 'fuse' them to correlate their information is increasingly becoming an important requirement for various diagnostic and therapeutic procedures. A variety of image registration methods have been developed but they remain limited to specific clinical applications. Assuming rigid body transformation, two images can be registered if their differences are calculated in terms of translation, rotation and scaling. This paper describes the development and testing of a new correlation based approach for three-dimensional image registration. First, the scaling factors introduced by the imaging devices are calculated and compensated for. Then, the two images become translation invariant by computing their three-dimensional Fourier magnitude spectra. Subsequently, spherical coordinate transformation is performed and then the three-dimensional rotation is computed using a novice approach referred to as p olar Shells . The method of polar shells maps the three angles of rotation into one rotation and two translations of a two-dimensional function and then proceeds to calculate them using appropriate transformations based on the Fourier invariance properties. A basic assumption in the method is that the three-dimensional rotation is constrained to one large and two relatively small angles. This assumption is generally satisfied in normal clinical settings. The new three-dimensional image registration method was tested with simulations using computer generated phantom data as well as actual clinical data. Performance analysis and accuracy evaluation of the method using computer simulations yielded errors in the sub-pixel range. (authors)

  9. The evaluation of a deformable image registration segmentation technique for semi-automating internal target volume (ITV) production from 4DCT images of lung stereotactic body radiotherapy (SBRT) patients

    International Nuclear Information System (INIS)

    Speight, Richard; Sykes, Jonathan; Lindsay, Rebecca; Franks, Kevin; Thwaites, David

    2011-01-01

    Purpose: To evaluate a deformable image registration (DIR) segmentation technique for semi-automating ITV production from 4DCT for lung patients, in terms of accuracy and efficiency. Methods: Twenty-five stereotactic body radiotherapy lung patients were selected in this retrospective study. ITVs were manually delineated by an oncologist and semi-automatically produced by propagating the GTV manually delineated on the mid-ventilation phase to all other phases using two different DIR algorithms, using commercial software. The two ITVs produced by DIR were compared to the manually delineated ITV using the dice similarity coefficient (DSC), mean distance between agreement and normalised DSC. DIR-produced ITVs were assessed for their clinical suitability and also the time savings were estimated. Results: Eighteen out of 25 ITVs had normalised DSC > 1 indicating an agreement with the manually produced ITV within 1 mm uncertainty. Four of the other seven ITVs were deemed clinically acceptable and three would require a small amount of editing. In general, ITVs produced by DIR were smoother than those produced by manual delineation. It was estimated that using this technique would save clinicians on average 28 min/patient. Conclusions: ABAS was found to be a useful tool in the production of ITVs for lung patients. The ITVs produced are either immediately clinically acceptable or require minimal editing. This approach represents a significant time saving for clinicians.

  10. Author Details

    African Journals Online (AJOL)

    PROMOTING ACCESS TO AFRICAN RESEARCH. AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search · USING AJOL · RESOURCES. Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads.

  11. Author Correction

    DEFF Research Database (Denmark)

    Gröbner, Susanne N; Worst, Barbara C; Weischenfeldt, Joachim

    2018-01-01

    In this Article, author Benedikt Brors was erroneously associated with affiliation number '8' (Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee, USA); the author's two other affiliations (affiliations '3' and '7', both at the German Cancer Researc...

  12. Author Details

    African Journals Online (AJOL)

    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... An algorithm to retrieve Land Surface Temperature using Landsat-8 Dataset Abstract PDF. ISSN: 2225-8531.

  13. Evaluation of Sufficiency of Subpoena Authority Within the Department of Defense in Support of General Crimes Investigations

    National Research Council Canada - National Science Library

    2001-01-01

    ... (including pornography and child solicitation). The NAPA panel recommended that DoD consider providing approval authority to the Services' General Counsels or to some other appropriate Service official...

  14. Characterization of Foliage Mutants for Plant Variety Registration

    International Nuclear Information System (INIS)

    Affrida Abu Hassan; Shuhaimi Shamsuddin; Zaiton Ahmad

    2011-01-01

    Breeding for new plant varieties requires a substantial investment in terms of skill, labour, material resources and financing. Thus, registration of new plant variety is important to ensure return of revenue and protection of the breeder's right. Before a new variety is registered, it has to comply certain requirements under Plant Variety Protection Act. One of the most important requirements is, the new species/variety must be morphologically distinguishable from existing plant varieties. This paper discusses detailed leaf characteristics of 4 foliage mutants produced by Malaysian Nuclear Agency as part of the requirement for new variety registration. (author)

  15. Pre-authorization processes have no effect on patients undergoing knee MRI in a pediatric setting when evaluated by specialists

    Energy Technology Data Exchange (ETDEWEB)

    Pierce, Drew; Kan, J.H.; Bisset, George S. [Texas Children' s Hospital, Department of Radiology, Houston, TX (United States); May, Megan [Texas Children' s Hospital, Department of Sports Medicine, Houston, TX (United States)

    2017-02-15

    Pre-authorization processes are often used by medical insurance companies to reduce costs by managing the utilization of advanced diagnostic imaging, and their impact on patient care is unclear. The purpose of our study is to determine if a pre-authorization process increases the rate of surgically significant abnormal knee MRI and surgical referrals compared with patients referred from pediatric orthopedic specialists who do not undergo a pre-authorization process. A retrospective study was performed; 124 patients were identified who were referred for knee MRI by a pediatric orthopedist. The study population included patients who underwent an insurance pre-authorization process and the control group consisted of those who did not. The results of the MRI and whether they were deemed surgically significant, in addition to surgical referral, were recorded and compared. The study and control groups showed no statistically significant difference in outcome with regard to surgically significant findings on MRI (p = 0.92) or whether the patient required surgery (p = 0.6). In this population, there is no difference in the likelihood of an abnormal knee MRI demonstrating surgically significant findings or referral to surgery in patients who did and those who did not undergo an insurance pre-authorization process when patients are referred from a pediatric orthopedic specialist. The insurance pre-authorization process does not appear to have an impact on patient diagnosis and treatment and may unnecessarily add bureaucracy and costs. (orig.)

  16. Contacts in the Office of Pesticide Programs, Registration Division

    Science.gov (United States)

    The Registration Division (RD) is responsible product registrations, amendments, registrations, tolerances, experimental use permits, and emergency exemptions for conventional chemical pesticides. Find contacts in this division.

  17. What drives Users' Website Registration?

    NARCIS (Netherlands)

    T. Li (Ting); P.A. Pavlou (Paul)

    2013-01-01

    textabstractUser registration is an important prerequisite for the success of many websites by enabling users to gain access to domain information and personalized content. It is not always desirable for users, however, because they need to disclose personal information. This paper examines what

  18. ACIR: automatic cochlea image registration

    Science.gov (United States)

    Al-Dhamari, Ibraheem; Bauer, Sabine; Paulus, Dietrich; Lissek, Friedrich; Jacob, Roland

    2017-02-01

    Efficient Cochlear Implant (CI) surgery requires prior knowledge of the cochlea's size and its characteristics. This information helps to select suitable implants for different patients. To get these measurements, a segmentation method of cochlea medical images is needed. An important pre-processing step for good cochlea segmentation involves efficient image registration. The cochlea's small size and complex structure, in addition to the different resolutions and head positions during imaging, reveals a big challenge for the automated registration of the different image modalities. In this paper, an Automatic Cochlea Image Registration (ACIR) method for multi- modal human cochlea images is proposed. This method is based on using small areas that have clear structures from both input images instead of registering the complete image. It uses the Adaptive Stochastic Gradient Descent Optimizer (ASGD) and Mattes's Mutual Information metric (MMI) to estimate 3D rigid transform parameters. The use of state of the art medical image registration optimizers published over the last two years are studied and compared quantitatively using the standard Dice Similarity Coefficient (DSC). ACIR requires only 4.86 seconds on average to align cochlea images automatically and to put all the modalities in the same spatial locations without human interference. The source code is based on the tool elastix and is provided for free as a 3D Slicer plugin. Another contribution of this work is a proposed public cochlea standard dataset which can be downloaded for free from a public XNAT server.

  19. Pain education in pre-registration professional health courses: a protocol for a scoping review.

    Science.gov (United States)

    Thompson, Kate; Milligan, James; Johnson, Mark I; Briggs, Michelle

    2016-07-18

    Pain is a global health concern causing significant health and social problems with evidence that patients experiencing pain are receiving inadequate care. The content of pain education in pre-registration professional health courses is thought to be lacking both in the UK and internationally which is unacceptable considering the prevalence of pain. Evaluating the effect of education is complex in that the outcome (improved healthcare) is some distance from the educational approach. Best evidence medical education has been proposed as a continuum between 'opinion-based teaching' and 'evidence-based teaching'. Searching for evidence to inform best practice in health education is complex. A scoping review provides a practical and comprehensive strategy to locate and synthesise literature of varied methodology including reports from a variety of sources. The aim of this article is to describe a protocol for a scoping review that will locate, map and report research, guidelines and policies for pain education in pre-registration professional health courses. The extent, range and nature of reports will be examined, and where possible titles for potential systematic review will be identified. Reports will be included for review that are directly relevant to the development of the pain curriculum in pre-registration professional health courses, eg nursing, medicine, physiotherapy. The search strategy will identify reports that include [pain] AND [pre-registration education or curriculum] AND [health professionals] in the title or abstract. Two authors will independently screen retrieved studies against eligibility criteria. A numerical analysis regarding the extent, nature and distribution of reports will be given along with a narrative synthesis to describe characteristics of relevant reports. Formal ethical approval was not required to undertake this scoping review. Findings will be published in scientific peer-reviewed journals and via conference presentations

  20. Modeling cancer registration processes with an enhanced activity diagram.

    Science.gov (United States)

    Lyalin, D; Williams, W

    2005-01-01

    Adequate instruments are needed to reflect the complexity of routine cancer registry operations properly in a business model. The activity diagram is a key instrument of the Unified Modeling Language (UML) for the modeling of business processes. The authors aim to improve descriptions of processes in cancer registration, as well as in other public health domains, through the enhancements of an activity diagram notation within the standard semantics of UML. The authors introduced the practical approach to enhance a conventional UML activity diagram, complementing it with the following business process concepts: timeline, duration for individual activities, responsibilities for individual activities within swimlanes, and descriptive text. The authors used an enhanced activity diagram for modeling surveillance processes in the cancer registration domain. Specific example illustrates the use of an enhanced activity diagram to visualize a process of linking cancer registry records with external mortality files. Enhanced activity diagram allows for the addition of more business concepts to a single diagram and can improve descriptions of processes in cancer registration, as well as in other domains. Additional features of an enhanced activity diagram allow to advance the visualization of cancer registration processes. That, in turn, promotes the clarification of issues related to the process timeline, responsibilities for particular operations, and collaborations among process participants. Our first experiences in a cancer registry best practices development workshop setting support the usefulness of such an approach.

  1. Efficient nonrigid registration using ranked order statistics

    DEFF Research Database (Denmark)

    Tennakoon, Ruwan B.; Bab-Hadiashar, Alireza; de Bruijne, Marleen

    2013-01-01

    of research. In this paper we propose a fast and accurate non-rigid registration method for intra-modality volumetric images. Our approach exploits the information provided by an order statistics based segmentation method, to find the important regions for registration and use an appropriate sampling scheme......Non-rigid image registration techniques are widely used in medical imaging applications. Due to high computational complexities of these techniques, finding appropriate registration method to both reduce the computation burden and increase the registration accuracy has become an intense area...... to target those areas and reduce the registration computation time. A unique advantage of the proposed method is its ability to identify the point of diminishing returns and stop the registration process. Our experiments on registration of real lung CT images, with expert annotated landmarks, show...

  2. Fuels Registration, Reporting, and Compliance Help

    Science.gov (United States)

    Information about the requirements for registration and health effects testing of new fuels or fuel additives and mandatory registration for fuels reporting and about mandatory reporting forms for parties regulated under EPA fuel programs.

  3. Author's capabilities in author indexing

    International Nuclear Information System (INIS)

    Ooi, Shoichi

    1988-01-01

    The purpose of this paper is to provide a author capability of current author indexing practices in journal literature indexing practices in 'Journal of Nuclear Science and Technology of Japan'. This Journal employed keywords freely assigned by author and not taken from INIS Thesaurus or other vocabulary list. Author examined 413 literatures, comparing keywords assigned by the literatures' authors with descriptor's (ATOMINDEX) assigned by an experienced professional indexer. The results of the comparisons showed that the average set of terms assigned by author included about 70% of all the terms assigned to the same literature by the professional indexer. Authors eventually would contribute, for the most effective point to create reference to information is at the time of its generation. Consequently, it may be possible to transfer them easily to descriptors in every secondary information system. (author)

  4. Fast and accurate registration of cranial CT images with A-mode ultrasound.

    Science.gov (United States)

    Fieten, Lorenz; Schmieder, Kirsten; Engelhardt, Martin; Pasalic, Lamija; Radermacher, Klaus; Heger, Stefan

    2009-05-01

    Within the CRANIO project, a navigation module based on preoperative computed tomography (CT) data was developed for Computer and Robot Assisted Neurosurgery. The approach followed for non-invasive user-interactive registration of cranial CT images with the physical operating space consists of surface-based registration following pre-registration based on anatomical landmarks. Surface-based registration relies on bone surface points digitized transcutaneously by means of an optically tracked A-mode ultrasound (US) probe. As probe alignment and thus bone surface point digitization may be time-consuming, we investigated how to obtain high registration accuracy despite inaccurate pre-registration and a limited number of digitized bone surface points. Furthermore, we aimed at efficient man-machine-interaction during the probe alignment process. Finally, we addressed the problem of registration plausibility estimation in our approach. We modified the Iterative Closest Point (ICP) algorithm, presented by Besl and McKay and frequently used for surface-based registration, such that it can escape from local minima of the cost function to be iteratively minimized. The random-based ICP (R-ICP) we developed is less influenced by the quality of the pre-registration as it can escape from local minima close to the starting point for iterative optimization in the 6D domain of rigid transformations. The R-ICP is also better suited to approximate the global minimum as it can escape from local minima in the vicinity of the global minimum, too. Furthermore, we developed both CT-less and CT-based probe alignment tools along with appropriate man-machine strategies for a more time-efficient palpation process. To improve registration reliability, we developed a simple plausibility test based on data readily available after registration. In a cadaver study, where we evaluated the R-ICP algorithm, the probe alignment tools, and the plausibility test, the R-ICP algorithm consistently

  5. A comparison of publicly available linear MRI stereotaxic registration techniques.

    Science.gov (United States)

    Dadar, Mahsa; Fonov, Vladimir S; Collins, D Louis

    2018-07-01

    atrophy related changes between passed and failed registrations. Our experiments show that the Revised BestLinReg had the best performance among the evaluated registration techniques while all techniques performed worse for images with higher levels of noise and non-uniformity as well as atrophy related changes. Copyright © 2018 Elsevier Inc. All rights reserved.

  6. Image/patient registration from (partial) projection data by the Fourier phase matching method

    International Nuclear Information System (INIS)

    Weiguo Lu; You, J.

    1999-01-01

    A technique for 2D or 3D image/patient registration, PFPM (projection based Fourier phase matching method), is proposed. This technique provides image/patient registration directly from sequential tomographic projection data. The method can also deal with image files by generating 2D Radon transforms slice by slice. The registration in projection space is done by calculating a Fourier invariant (FI) descriptor for each one-dimensional projection datum, and then registering the FI descriptor by the Fourier phase matching (FPM) method. The algorithm has been tested on both synthetic and experimental data. When dealing with translated, rotated and uniformly scaled 2D image registration, the performance of the PFPM method is comparable to that of the IFPM (image based Fourier phase matching) method in robustness, efficiency, insensitivity to the offset between images, and registration time. The advantages of the former are that subpixel resolution is feasible, and it is more insensitive to image noise due to the averaging effect of the projection acquisition. Furthermore, the PFPM method offers the ability to generalize to 3D image/patient registration and to register partial projection data. By applying patient registration directly from tomographic projection data, image reconstruction is not needed in the therapy set-up verification, thus reducing computational time and artefacts. In addition, real time registration is feasible. Registration from partial projection data meets the geometry and dose requirements in many application cases and makes dynamic set-up verification possible in tomotherapy. (author)

  7. 12 CFR 583.18 - Registrant.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Registrant. 583.18 Section 583.18 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY DEFINITIONS FOR REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.18 Registrant. The term registrant means a savings and loan...

  8. Solid Mesh Registration for Radiotherapy Treatment Planning

    DEFF Research Database (Denmark)

    Noe, Karsten Østergaard; Sørensen, Thomas Sangild

    2010-01-01

    We present an algorithm for solid organ registration of pre-segmented data represented as tetrahedral meshes. Registration of the organ surface is driven by force terms based on a distance field representation of the source and reference shapes. Registration of internal morphology is achieved usi...

  9. 32 CFR 634.19 - Registration policy.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Registration policy. 634.19 Section 634.19 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS MOTOR VEHICLE TRAFFIC SUPERVISION Motor Vehicle Registration § 634.19 Registration policy. (a) Motor vehicles will be...

  10. Comparison of manual vs. automated multimodality (CT-MRI) image registration for brain tumors

    International Nuclear Information System (INIS)

    Sarkar, Abhirup; Santiago, Roberto J.; Smith, Ryan; Kassaee, Alireza

    2005-01-01

    Computed tomgoraphy-magnetic resonance imaging (CT-MRI) registrations are routinely used for target-volume delineation of brain tumors. We clinically use 2 software packages based on manual operation and 1 automated package with 2 different algorithms: chamfer matching using bony structures, and mutual information using intensity patterns. In all registration algorithms, a minimum of 3 pairs of identical anatomical and preferably noncoplanar landmarks is used on each of the 2 image sets. In manual registration, the program registers these points and links the image sets using a 3-dimensional (3D) transformation. In automated registration, the 3 landmarks are used as an initial starting point and further processing is done to complete the registration. Using our registration packages, registration of CT and MRI was performed on 10 patients. We scored the results of each registration set based on the amount of time spent, the accuracy reported by the software, and a final evaluation. We evaluated each software program by measuring the residual error between 'matched' points on the right and left globes and the posterior fossa for fused image slices. In general, manual registration showed higher misalignment between corresponding points compared to automated registration using intensity matching. This error had no directional dependence and was, most of the time, larger for a larger structure in both registration techniques. Automated algorithm based on intensity matching also gave the best results in terms of registration accuracy, irrespective of whether or not the initial landmarks were chosen carefully, when compared to that done using bone matching algorithm. Intensity-matching algorithm required the least amount of user-time and provided better accuracy

  11. 21 CFR 710.8 - Misbranding by reference to registration or to registration number.

    Science.gov (United States)

    2010-04-01

    ... HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY REGISTRATION OF COSMETIC PRODUCT ESTABLISHMENTS § 710.8 Misbranding by reference to registration or to registration number. Registration of a cosmetic product... products by the Food and Drug Administration. Any representation in labeling or advertising that creates an...

  12. 21 CFR 710.6 - Notification of registrant; cosmetic product establishment registration number.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Notification of registrant; cosmetic product... OF HEALTH AND HUMAN SERVICES (CONTINUED) COSMETICS VOLUNTARY REGISTRATION OF COSMETIC PRODUCT ESTABLISHMENTS § 710.6 Notification of registrant; cosmetic product establishment registration number. The...

  13. 21 CFR 1301.52 - Termination of registration; transfer of registration; distribution upon discontinuance of business.

    Science.gov (United States)

    2010-04-01

    ... discontinues business or professional practice. Any registrant who ceases legal existence or discontinues... registration; distribution upon discontinuance of business. 1301.52 Section 1301.52 Food and Drugs DRUG... of registration; transfer of registration; distribution upon discontinuance of business. (a) Except...

  14. Co-registration of the BNCT treatment planning images for clinical practice

    International Nuclear Information System (INIS)

    Salli, Eero; Seppaelae, Tiina; Kankaanranta, Leena; Asikainen, Sami; Savolainen, Sauli; Koivunoro, Hanna

    2006-01-01

    We have co-registered MRI, CT and FBPA-PET images for BNCT in clinical practice. Co-registration improves the spatial accuracy of the treatment planning by enabling use of information from all the co-registered modalities. The multimodal co-registration has been implemented as a service product provided by the Imaging Center of Helsinki University Central Hospital to other departments. To increase the accuracy of co-registration and patient positioning in the head area BNCT, a patient-specific fixation mask suitable for PET, MRI and CT was developed. The goal of the fixation mask is to normalize the orientation of the patient's head and neck. Co-registration is performed at the image processing unit by using a rigid body model, mutual-information based algorithms and partly in-house developed software tools. The accuracy of co-registration is verified by comparing the locations of the external skin markers and anatomical landmarks in different modalities. After co-registration, the images are transformed and covered into a format required by the BNCT dose-planning software and set to the dose-planning unit of the hospital. So far co-registration has been done for 22 patients. The co-registration protocol has proved to be reliable and efficient. Some registration errors are seen on some patients in the neck area because the rigid-body model used in co-registration is not fully valid for the brain-neck entity. The registration accuracy in this area could likely be improved by implementing a co-registration procedure utilizing a partly non-rigid body model. (author)

  15. 76 FR 57058 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

    Science.gov (United States)

    2011-09-15

    ...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... has been developed for veterinary use by the International Cooperation on Harmonisation of Technical... been undertaken by regulatory authorities and industry associations to promote the international...

  16. 78 FR 14308 - International Cooperation on Harmonisation of Technical Requirements for Registration of...

    Science.gov (United States)

    2013-03-05

    ...] International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal... been developed for veterinary use by the International Cooperation on Harmonisation of Technical... regulatory authorities and industry associations to promote the international harmonization of regulatory...

  17. Author Details

    African Journals Online (AJOL)

    Visemih, Willium Muffee. Vol 9, No 2 (2001) - Articles The Role Of Internal Control In The Rural Development Of Cameroon: The Case Of The South West Development Authority (Soweda) Abstract. ISSN: 0856-6372. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's ...

  18. Author Details

    African Journals Online (AJOL)

    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Abstract PDF · Vol 3, No 6 (2011) - Articles Mixed convection flow and heat transfer in a vertical wavy channel containing porous and fluid layer with traveling thermal waves. Abstract PDF · Vol 3, No 8 ...

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    African Journals Online (AJOL)

    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Singh, J. Vol 3, No 2 (2011) - Articles Plane waves in a rotating generalized thermo-elastic solid with voids. Abstract PDF. ISSN: 2141-2839. AJOL African Journals Online. HOW TO USE AJOL.

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Vol 12 (2008) - Articles On the wave equations of shallow water with rough bottom topography. Abstract · Vol 14 (2009) - Articles Energy generation in a plant due to variable sunlight intensity

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Iliopsoas haematoma in a rugby player. Abstract PDF · Vol 29, No 1 (2017) - Articles The use of negative pressure wave treatment in athlete recovery. Abstract PDF. ISSN: 2078-516X. AJOL African ...

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Ismail, A. Vol 9, No 3S (2017): Special Issue - Articles Investigate of wave absorption performance for oil palm frond and empty fruit bunch at 5.8 GHz. Abstract PDF · Vol 9, No 3S (2017): Special Issue ...

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Isa, M.F.M.. Vol 9, No 3S (2017): Special Issue - Articles Experimental and numerical investigation on blast wave propagation in soil structure. Abstract PDF · Vol 9, No 3S (2017): Special Issue - ...

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... No 3S (2017): Special Issue - Articles Experimental and numerical investigation on blast wave propagation in soil structure. Abstract PDF · Vol 9, No 3S (2017): Special Issue - Articles Simulation on ...

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Duwa, S S. Vol 8 (2004) - Articles Lower hybrid waves instability in a velocity–sheared inhomogenous charged dust beam. Abstract · Vol 9 (2005) - Articles The slide away theory of lower hybrid bursts

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Vol 45 (2016) - Articles From vectors to waves and streams: An alternative approach to semantic maps1. Abstract PDF · Vol 48 (2017) - Articles Introduction: 'n Klein ietsie for Johan Oosthuizen

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... to blast loadings. Abstract PDF · Vol 9, No 3S (2017): Special Issue - Articles Experimental and numerical investigation on blast wave propagation in soil structure. Abstract PDF. ISSN: 1112-9867.

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... The use of negative pressure wave treatment in athlete recovery. Abstract PDF · Vol 29, No 1 (2017) - Articles The prevalence, risk factors predicting injury and the severity of injuries sustained during ...

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    Author Details. Journal Home > Advanced Search > Author Details. Log in or Register to get access to full text downloads. ... Vol 29, No 1 (2017) - Articles The use of negative pressure wave treatment in athlete recovery. Abstract PDF · Vol 29, No 1 (2017) - Articles The prevalence, risk factors predicting injury and the ...

  10. Farewell to Arms: A Plan for Evaluating the 2001 Authorization for Use of Military Force and Its Alternatives

    Science.gov (United States)

    2014-09-01

    measures. For instance, the executive branch has relied on it to authorize warrantless electronic surveillance of citizens, pursue targeted killings of...House Trade Paperback ed., 2014, original copyright Random House Publishing 1984), 245. 490 Breckenridge and Zimbardo, “The Strategy of Terrorism...enhance legitimacy, Congress should codify relevant “ offences against the Law of Nations.” Specifically, it should interpret and codify the laws of war

  11. Safety evaluation report related to the operation of Sequoyah Nuclear Plant, Units 1 and 2, Docket Nos. 50-327 and 50-328, Tennessee Valley Authority

    International Nuclear Information System (INIS)

    1982-12-01

    Supplement No. 6 to the Safety Evaluation Report (SER) related to the operation of the Tennessee Valley Authority's Sequoyah Nuclear Plant, Units 1 and 2, located in Hamilton County, Tennessee, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. The purpose of this supplement is to update the staff's evaluations of the issues related to the hydrogen mitigation system identified in the SER and previous supplements as needing resolution

  12. Authoring Tools

    Science.gov (United States)

    Treviranus, Jutta

    Authoring tools that are accessible and that enable authors to produce accessible Web content play a critical role in web accessibility. Widespread use of authoring tools that comply to the W3C Authoring Tool Accessibility Guidelines (ATAG) would ensure that even authors who are neither knowledgeable about nor particularly motivated to produce accessible content do so by default. The principles and techniques of ATAG are discussed. Some examples of accessible authoring tools are described including authoring tool content management components such as TinyMCE. Considerations for creating an accessible collaborative environment are also covered. As part of providing accessible content, the debate between system-based personal optimization and one universally accessible site configuration is presented. The issues and potential solutions to address the accessibility crisis presented by the advent of rich internet applications are outlined. This challenge must be met to ensure that a large segment of the population is able to participate in the move toward the web as a two-way communication mechanism.

  13. Summer Camp July 2017 - Registration

    CERN Multimedia

    EVE et École

    2017-01-01

    The CERN Staff Association’s Summer Camp will be open for children from 4 to 6 years old during four weeks, from 3 to 28 July. Registration is offered on a weekly basis for 450 CHF, lunch included. This year, the various activities will revolve around the theme of the Four Elements. Registration opened on 20 March 2017 for children currently attending the EVE and School of the Association. It will be open from 3 April for children of CERN Members of Personnel, and starting from 24 April for all other children. The general conditions are available on the website of the EVE and School of CERN Staff Association: http://nurseryschool.web.cern.ch. For further questions, please contact us by email at Summer.Camp@cern.ch.

  14. Alternative face models for 3D face registration

    Science.gov (United States)

    Salah, Albert Ali; Alyüz, Neşe; Akarun, Lale

    2007-01-01

    3D has become an important modality for face biometrics. The accuracy of a 3D face recognition system depends on a correct registration that aligns the facial surfaces and makes a comparison possible. The best results obtained so far use a one-to-all registration approach, which means each new facial surface is registered to all faces in the gallery, at a great computational cost. We explore the approach of registering the new facial surface to an average face model (AFM), which automatically establishes correspondence to the pre-registered gallery faces. Going one step further, we propose that using a couple of well-selected AFMs can trade-off computation time with accuracy. Drawing on cognitive justifications, we propose to employ category-specific alternative average face models for registration, which is shown to increase the accuracy of the subsequent recognition. We inspect thin-plate spline (TPS) and iterative closest point (ICP) based registration schemes under realistic assumptions on manual or automatic landmark detection prior to registration. We evaluate several approaches for the coarse initialization of ICP. We propose a new algorithm for constructing an AFM, and show that it works better than a recent approach. Finally, we perform simulations with multiple AFMs that correspond to different clusters in the face shape space and compare these with gender and morphology based groupings. We report our results on the FRGC 3D face database.

  15. Registration of indoor TLS data: in favor of a probabilistic approach initialized by geo-location

    International Nuclear Information System (INIS)

    Hullo, Jean-Francois

    2013-01-01

    Many pre-maintenance operations of industrial facilities currently resort on to three dimensional CAD models. The acquisition of these models is performed from point clouds measured by Terrestrial Laser Scanning (TLS). When the scenes are complex, several view points for scanning, also known as stations, are necessary to ensure the completeness and the density of the survey data. The generation of a global point cloud, i.e. the expression of all the acquired data in a common reference frame, is a crucial step called registration. During this process, the pose parameters are estimated. If the GNSS Systems are now a solution for many outdoor scenes, the registration of indoor TLS data still remains a challenge. The goal of this thesis is to improve the acquisition process of TLS data in industrial environments. The aim is to guarantee the precision and accuracy of acquired data, while optimizing on-site acquisition time and protocols by, as often as possible, freeing the operator from the constraints inherent to conventional topography surveys. In a first part, we consider the state of the art of the means and methods used during the acquisition of dense point clouds of complex interior scenes (Part I). In a second part, we study and evaluate the data available for the registration: terrestrial laser data, primitive reconstruction algorithms in point clouds and indoor geo-location Systems (Part II). In the third part, we then formalize and experiment a registration algorithm based on the use of matched primitives, reconstructed from per station point clouds ( Part III). We finally propose a probabilistic approach for matching primitives, allowing the integration of a priori information and uncertainty in the constraints System used for calculating poses (Part IV). The contributions of our work are as follows: - to take a critical look at current methods of TLS data acquisition in industrial environments, - to evaluate, through experimentations, the information

  16. Pre-processing, registration and selection of adaptive optics corrected retinal images.

    Science.gov (United States)

    Ramaswamy, Gomathy; Devaney, Nicholas

    2013-07-01

    In this paper, the aim is to demonstrate enhanced processing of sequences of fundus images obtained using a commercial AO flood illumination system. The purpose of the work is to (1) correct for uneven illumination at the retina (2) automatically select the best quality images and (3) precisely register the best images. Adaptive optics corrected retinal images are pre-processed to correct uneven illumination using different methods; subtracting or dividing by the average filtered image, homomorphic filtering and a wavelet based approach. These images are evaluated to measure the image quality using various parameters, including sharpness, variance, power spectrum kurtosis and contrast. We have carried out the registration in two stages; a coarse stage using cross-correlation followed by fine registration using two approaches; parabolic interpolation on the peak of the cross-correlation and maximum-likelihood estimation. The angle of rotation of the images is measured using a combination of peak tracking and Procrustes transformation. We have found that a wavelet approach (Daubechies 4 wavelet at 6th level decomposition) provides good illumination correction with clear improvement in image sharpness and contrast. The assessment of image quality using a 'Designer metric' works well when compared to visual evaluation, although it is highly correlated with other metrics. In image registration, sub-pixel translation measured using parabolic interpolation on the peak of the cross-correlation function and maximum-likelihood estimation are found to give very similar results (RMS difference 0.047 pixels). We have confirmed that correcting rotation of the images provides a significant improvement, especially at the edges of the image. We observed that selecting the better quality frames (e.g. best 75% images) for image registration gives improved resolution, at the expense of poorer signal-to-noise. The sharpness map of the registered and de-rotated images shows increased

  17. Author Details

    African Journals Online (AJOL)

    Mordi, JI. Vol 27, No 1 (2009) - Articles Production and quality evaluation of probiotic soy milk. Abstract · Vol 29, No 1 (2011) - Articles Production and Evaluation of Jam from Roselle Calyx Extract Abstract · Vol 29, No 2 (2011) - Articles Production and Evaluation of Ice Cream from Nigerian Tiger-Nut Milk Extract Abstract.

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    Seeking Behavior Towards Dysmenorrhea among Female Students of a Private University in Ogun State, Nigeria Abstract PDF. ISSN: 2320-2041. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

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    Monitoring on Attitudes toward Internet Fraud among Undergraduate Students of Obafemi Awolowo University, Ile-Ife Abstract PDF. ISSN: 2070-0083. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

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    , Incubators and the Effects of a Spray-Disinfectant - A Quarterly Ammonium Compound Abstract. ISSN: 1116-1043. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    676X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER RESOURCES.

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    , happiness, hope and marital satisfaction among married people in Makurdi Metropolis, Nigeria Abstract. ISSN: 1596-9231. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    communication-style and parental neglect as predictors of aggressive tendencies among Secondary School adolescents. Abstract. ISSN: 0189-0263. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

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    Journal Home > Advanced Search > Author Details. Log in or Register to ... No 1 (2014) - Articles Knowledge and Attitudes towards Basic Cardiopulmonary Resuscitation (CPR) among Community Nurses in Remo Area of Ogun State, Nigeria

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    Mental State Examination and the Montreal Cognitive Assessment Test in schizophrenia. Abstract PDF. ISSN: 2078-6786. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    ” Passages in the Context of Homosexuality Controversy: A Nigerian Perspective Abstract PDF. ISSN: 2141-7040. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    plant interactions and arthropod trophic structure in an endangered grassland in the Free State province, South Africa Abstract. ISSN: 1022-0119. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

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    Journal Home > Advanced Search > Author Details. Log in or Register to get ... Optical bus of centralized relay protection and automation system of medium voltage switchgear for data collection and transmission. Abstract PDF. ISSN: 1112- ...

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    Journal Home > Advanced Search > Author Details ... Design and Implementation of an M/M/1 Queuing Model Algorithm and its Applicability in ... Vehicle Identification Technology to Intercept Small Arms and Ammunition on Nigeria Roads

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    509X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER RESOURCES.

  11. Complexity and accuracy of image registration methods in SPECT-guided radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Yin, L S; Duzenli, C; Moiseenko, V [Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC, V6T 1Z1 (Canada); Tang, L; Hamarneh, G [Computing Science, Simon Fraser University, 9400 TASC1, Burnaby, BC, V5A 1S6 (Canada); Gill, B [Medical Physics, Vancouver Cancer Centre, BC Cancer Agency, 600 West 10th Ave, Vancouver, BC, V5Z 4E6 (Canada); Celler, A; Shcherbinin, S [Department of Radiology, University of British Columbia, 828 West 10th Ave, Vancouver, BC, V5Z 1L8 (Canada); Fua, T F; Thompson, A; Sheehan, F [Radiation Oncology, Vancouver Cancer Centre, BC Cancer Agency, 600 West 10th Ave, Vancouver, BC, V5Z 4E6 (Canada); Liu, M [Radiation Oncology, Fraser Valley Cancer Centre, BC Cancer Agency, 13750 9th Ave, Surrey, BC, V3V 1Z2 (Canada)], E-mail: lyin@bccancer.bc.ca

    2010-01-07

    The use of functional imaging in radiotherapy treatment (RT) planning requires accurate co-registration of functional imaging scans to CT scans. We evaluated six methods of image registration for use in SPECT-guided radiotherapy treatment planning. Methods varied in complexity from 3D affine transform based on control points to diffeomorphic demons and level set non-rigid registration. Ten lung cancer patients underwent perfusion SPECT-scans prior to their radiotherapy. CT images from a hybrid SPECT/CT scanner were registered to a planning CT, and then the same transformation was applied to the SPECT images. According to registration evaluation measures computed based on the intensity difference between the registered CT images or based on target registration error, non-rigid registrations provided a higher degree of accuracy than rigid methods. However, due to the irregularities in some of the obtained deformation fields, warping the SPECT using these fields may result in unacceptable changes to the SPECT intensity distribution that would preclude use in RT planning. Moreover, the differences between intensity histograms in the original and registered SPECT image sets were the largest for diffeomorphic demons and level set methods. In conclusion, the use of intensity-based validation measures alone is not sufficient for SPECT/CT registration for RTTP. It was also found that the proper evaluation of image registration requires the use of several accuracy metrics.

  12. Subspace-Based Holistic Registration for Low-Resolution Facial Images

    Directory of Open Access Journals (Sweden)

    Boom BJ

    2010-01-01

    Full Text Available Subspace-based holistic registration is introduced as an alternative to landmark-based face registration, which has a poor performance on low-resolution images, as obtained in camera surveillance applications. The proposed registration method finds the alignment by maximizing the similarity score between a probe and a gallery image. We use a novel probabilistic framework for both user-independent as well as user-specific face registration. The similarity is calculated using the probability that the face image is correctly aligned in a face subspace, but additionally we take the probability into account that the face is misaligned based on the residual error in the dimensions perpendicular to the face subspace. We perform extensive experiments on the FRGCv2 database to evaluate the impact that the face registration methods have on face recognition. Subspace-based holistic registration on low-resolution images can improve face recognition in comparison with landmark-based registration on high-resolution images. The performance of the tested face recognition methods after subspace-based holistic registration on a low-resolution version of the FRGC database is similar to that after manual registration.

  13. The Insight ToolKit Image Registration Framework

    Directory of Open Access Journals (Sweden)

    Brian eAvants

    2014-04-01

    Full Text Available Publicly available scientific resources help establish evaluation standards, provide a platform for teaching and improve reproducibility. Version 4 of the Insight ToolKit ( ITK4 seeks to es- tablish new standards in publicly available image registration methodology. ITK4 makes severaladvances in comparison to previous versions of ITK. ITK4 supports both multivariate images and objective functions; it also unifies high-dimensional (deformation field and low-dimensional (affine transformations with metrics that are reusable across transform types and with com- posite transforms that allow arbitrary series of geometric mappings to be chained together seamlessly. Metrics and optimizers take advantage of multi-core resources, when available.Furthermore, ITK4 reduces the parameter optimization burden via principled heuristics that automatically set scaling across disparate parameter types (rotations versus translations. A related approach also constrains steps sizes for gradient-based optimizers. The result is that tuning for different metrics and/or image pairs is rarely necessary allowing the researcher tomore easily focus on design/comparison of registration strategies. In total, the ITK4 contribu- tion is intended as a structure to support reproducible research practices, will provide a more extensive foundation against which to evaluate new work in image registration and also enable application level programmers a broad suite of tools on which to build. Finally, we contextu- alize this work with a reference registration evaluation study with application to pediatric brainlabeling.

  14. Authors' Response:

    Directory of Open Access Journals (Sweden)

    E Auger

    2012-03-01

    Full Text Available In this article, the authors suggest that one method for increasing awareness of the benefits of data sharing can be affected by administering a survey, hopefully encouraging either a minority or majority influence on other members of the behavioural science community. The authors describe the process for creating such a survey and provide their survey, although untested. This is a well-timed article as the existing literature on social and behavioural science data is quite thin. The majority/minority influence of norms is a nice theoretical construct to explore. This is definitely one approach to increase awareness of the benefits of data sharing.

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    Arhewoh, MI. Vol 9, No 1 (2012) - Articles Evaluation of the Antidiarrhoeal Activity of the Aqueous Rhizome Extract of Curcuma Longa Abstract · Vol 9, No 2 (2012) - Articles Comparative evaluation of the suspending properties of some starches. Abstract. ISSN: 1596-8499. AJOL African Journals Online. HOW TO USE AJOL.

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    Evaluation of Physicochemical Properties of Biodiesel Produced From Some Vegetable Oils of Nigeria Origin Abstract PDF · Vol 19, No 1 (2011) - Articles Evaluation of Nutrient and Anti-nutrient Contents of Parkia biglobosa (L.) Flower Abstract PDF · Vol 19, No 1 (2011) - Articles Influence of Fatty Acid Methyl Esters on Fuel ...

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    Odeniyi, MA. Vol 14, No 2 (2011) - Articles Evaluation of bioadhesive properties of natural and modified banana starches. Abstract PDF · Vol 15, No 1 (2012) - Articles Evaluation of Pharmaceutical and Chemical Equivalence of Selected Brands of Diclofenac Sodium Tablets Abstract PDF · Vol 15, No 3 (2012) - Articles

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    Abstract · Vol 30, No 2 (2014) - Articles Evaluation of Native and Cross-Linked Acacia Senegal Gums as Sustained Release Agents in Tablet Formulations Abstract · Vol 31, No 1 (2015) - Articles Preparation of Liquisolid Compacts of Diclofenac Sodium and Evaluation of their Release Enahancing and Retarding Properties

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    Attama, AA. Vol 3, No 2 (2005) - Articles In vitro study of the interaction between amoxicillin and norfloxacin with lansoprazole. Abstract · Vol 3, No 2 (2005) - Articles Evaluation of snail mucin as bioadhesive agent for the delivery of chlorpropamide. Abstract · Vol 7, No 1 (2009) - Articles In-vitro evaluation of bioadhesive and ...

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    Ozumba, AU. Vol 29, No 1 (2011) - Articles Production and Evaluation of Jam from Roselle Calyx Extract Abstract · Vol 29, No 2 (2011) - Articles Production and Evaluation of Ice Cream from Nigerian Tiger-Nut Milk Extract Abstract · Vol 31, No 1 (2013) - Articles Effect of Sources of Fibre on Performance of Growing Snail

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    Manga, A.A.. Vol 10, No 1 (2017) - Articles Effect of different concentrations of aqueous Ascophyllum nodosum extract on flowering and fruiting in some vegetables. Abstract PDF. ISSN: 2006-6996. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    Manga, Anicet. Vol 11, No 5 (2017) - Articles Le champignon arbusculaire Glomus aggregatum améliore la nutrition minérale de Acacia seyal soumis au stress salin progressif. Abstract PDF. ISSN: 1997-342X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More ...

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    Manga, SB. Vol 29, No 2 (2008) - Articles Larvicidal efficacy of stock Bacillus sphaericus on local species of Anopheles mosquito in Sokoto, Nigeria Abstract. ISSN: 1117-4145. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Manga, T. Tiki. Vol 8, No 2 (2000) - Articles Chemical composition of Ricinodendron heudelotii: An indigenous fruit tree in southern Cameroon Abstract. ISSN: 2072-6589. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms ...

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    Egah, DZ. Vol 54, No 2 (2008) - Articles Poliomyelitis: An Assessment of the Knowledge of Women in Jos Nigeria and Implications for its Global Eradication Early 21st Century Abstract. ISSN: 0189-0964. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    Jombo, GTA. Vol 54, No 2 (2008) - Articles Poliomyelitis: An Assessment of the Knowledge of Women in Jos Nigeria and Implications for its Global Eradication Early 21st Century Abstract. ISSN: 0189-0964. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    Fatiregun, AA. Vol 7, No 2 (2008) - Articles Poliomyelitis in Osun State, Nigeria: Two Confirmed Cases After 6 years Without Polio Abstract. ISSN: 1595-8272. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions ...

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    Eggers, R. Vol 84, No 10 (1994) - Articles Eradication of poliomyelitis in South Africa Abstract PDF. ISSN: 0256-95749. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER ...

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    Adeyemo, Lateef Kayode. Vol 13 (2017) - Articles Legalising same sex marriage and cloning: a need for ethical consideration. Abstract PDF. ISSN: 1597-474X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Uzoma, EF. Vol 1, No 3 (2010) - Articles Challenges and Implications of Genesis 2:18 – 24 on Same-Sex Marriage for the Contemporary Society Abstract PDF. ISSN: 2006-5442. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Wynchank, Dora. Vol 9, No 2 (2006) - Articles Guest Editorial Psychiatry and same sex marriage: are we involved? Abstract PDF. ISSN: 1994-8220. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Odiase-Alegimenlen, OA. Vol 3, No 1 (2014) - Articles Same sex marriage: Nigeria at the middle of western politics. Abstract PDF. ISSN: 2304-8239. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Van Staden, A. Vol 23, No 3 (2017) - Articles Self-reported symptoms of eating disorders amongst university dance students. Abstract. ISSN: 1117-4315. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of ...

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    Cottle, Edward. Vol 7, No 1 (2003) - Articles Realising the right of access to water: Pipe dream or watershed? Abstract PDF. ISSN: 2077-4907. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Elbusaidy, Hemed. Vol 4, No 2 (2015) - Articles Variant Anatomy of Intracranial Part of Middle Meningeal Artery in a Kenyan Population Abstract PDF. ISSN: 2305-9478. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Hurst, NL. Vol 47, No 5 (1973) - Articles Communication between Paranasal Sinuses and Meninges after Trauma Abstract PDF. ISSN: 0256-95749. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Okolie, CJ. Vol 7, No 1 (2012) - Articles Transformation of Shuttle Radar Topography Mission (SRTM) Digital Elevation Data to Nigerian Height System Abstract. ISSN: 1597-8826. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Adzandeh, EA. Vol 7, No 1 (2012) - Articles Transformation of Shuttle Radar Topography Mission (SRTM) Digital Elevation Data to Nigerian Height System Abstract. ISSN: 1597-8826. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Ismagilov, I.I.. Vol 9, No 2S (2017): Special Issue - Articles General method of synthesis by PLIC/FPGA digital devices to perform discrete orthogonal transformations. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    Ngozi-Olehi, LC. Vol 9, No 1 (2011) - Articles Chemical Education: A Tool for Wealth Creation from Waste Management Abstract. ISSN: 1596-8308. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Fotedar, R. Vol 33, No 1 (2011) - Articles Seasonal variations of agar extracted from different life stages of Gracilaria cliftonii (Gracilariales, Rhodophyta) from Western Australia Abstract. ISSN: 1814-232X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    Singh, Jai Govind. Vol 7, No 3 (2015): Supplement - Articles Impact of plug-in electric vehicles on voltage unbalance in distribution systems. Abstract PDF. ISSN: 2141-2839. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms ...

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    Osula, FO. Vol 6, No 1-2 (2014) - Articles Sub-acute hepatotoxicity of Pausinystalia yohimbe bark extract (Burantashi) in male albino rats (Rattus novergicus) Abstract. ISSN: 2251-0079. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Oliha, FO. Vol 33, No 2 (2014) - Research papers. Web Portal Usability among Nigerian University Students: A Case Study of University Of Benin, Nigeria Abstract PDF. ISSN: 2467-8821. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Quaye-Ballard, J A. Vol 27, No 2 (2007) - Articles Usability testing: using “think aloud” method in testing cartographic product. Abstract PDF. ISSN: 0855-0395. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions ...

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    Odubamowo, Kehinde Hussein. Vol 34, No 2 (2017) - Articles Dysmenorrhea among female students at a teaching hospital in South‑Western Nigeria Abstract PDF. ISSN: 0189-5117. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Ugboajah, PKN. Vol 9 (2012) - Articles “We Saw No Real Outstanding Leaders”: Britain's Perception of Nigerian Nationalist Class in Colonial Nigeria Abstract. ISSN: 1597-3778. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Zu, YG. Vol 60 (2007) - Articles Supercritical Fluid Extraction of Seed Oil from Chinese Licorice Glycyrrhiza uralensis Fisch.): Chemical Composition and Antibacterial Activity Abstract PDF. ISSN: 0379-4350. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    Ezeja, Maxwell I. Vol 53, No 3 (2017) - Articles Antioxidant, anti-inflammatory and antinociceptive activities of methanolic extract of Justicia secunda Vahl leaf. Abstract PDF. ISSN: 2090-2948. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Koona, OES. Vol 9, No 2 (2012) - Articles Effect of the Aqueous Extract of Justicia insularis T. Anders (Acanthaceae) on Ovarian Folliculogenesis and Fertility of Female Rats Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    Murluki, AW. Vol 14, No 2 (2012) - Articles Effect of rain water harvesting and drip irrigation on crop performance in an arid and semi-arid environment. Abstract. ISSN: 1561-7645. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Imtiyaz, M. Vol 27, No 2 (2007) - Articles Yield, irrigation production efficiency and economic returns of broccoli under variable drip irrigation and lateral spacing. Abstract PDF. ISSN: 0855-0395. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    Medugu, D W. Vol 18, No 2 (2006) - Articles Design and development of solar still for effectiveness in eliminating microbial contamination and salt in Mubi, Adamawa State, Nigeria Abstract PDF. ISSN: 1595-0611. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More ...

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    Osarolube, E. Vol 7, No 2 (2008) - Articles Single effect green house type solar still for portable water supply. Abstract. ISSN: 1118-1931. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

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    Chukwuma, FO. Vol 4, No 1 (2006) - Articles Use of Straight –Run Gasoline (Srg) as A Leaching Solvent for Oil Palm (Elaeis Guineensis) Kernel Seed Abstract. ISSN: 1596-3497. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Sanusi, AA. Vol 14, No 1 (2008) - Articles Hepatorenal Syndrome In Nigeria: A Review of Pathophysiology, Clinical Features and Management Abstract. ISSN: 0331-3727. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms ...

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    Magendzo, A. Vol 29, No 2 (2011) - Articles Teaching recent history in countries that have experienced human rights violations: Case studies from Chile Abstract. ISSN: 0258-2236. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Asaah, A H. Vol 23, No 1 (2007): - Articles Pan-Africanism, inter-African migration and crisis of national integration in the African novel. Abstract. ISSN: 0855-4412. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Nyangena, KO. Vol 6, No 1-2 (2003) - Articles Jomo Kenyatta: An Epitome of Indigenous Pan-Africanism, Nationalism and Intellectual Production in Kenya Abstract PDF. ISSN: 0850-7902. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Njubi, Francis. Vol 15, No 1 (2001): Media Freedom and Human Rights - Articles New Media, Old Struggles: Pan Africanism, Anti-racism and Information Technology Details. ISSN: 0256-004. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Forje, JW. Vol 6, No 1-2 (2003) - Articles Self-Determination, Nationalism, Development and Pan-Africanism Stuck on the Runway: Are Intellectuals to be Blamed? Abstract PDF. ISSN: 0850-7902. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL ...

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    border life, pan-africanism, and identity in Ahmadou Kourouma's novels. Abstract. ISSN: 0254-4296. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners ...

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    Paul, Fintan. Vol 5, No 1 (2017) - Articles Government expenditure and economic growth nexus: Wagner's law or Keynesian hypothesis for Tanzania? Abstract PDF. ISSN: 1821-8148. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Qi, Qing. Vol 29, No 2 (2017) - Articles Psychological health among Chinese college students: a rural/urban comparison. Abstract. ISSN: 1728-0583. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Sumera, Matthew. Vol 12, No 1-2 (2015) - Articles Johnson, Bruce & Martin Cloonan (2009). Dark Side of the Tune: Popular Music and Violence Abstract. ISSN: 2070-626X. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms ...

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    Adido, J. Vol 16, No 1 (2008) - Articles Vision of Strabismic Children in Ilorin, Nigeria Abstract PDF. ISSN: 2468-8363. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER ...

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    Elmehashi, MO. Vol 9, No 4 (2014) - Articles Hysteroscopy in Libyan women with Recurrent Pregnancy Loss Abstract. ISSN: 1858-5051. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

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    Laleye, F O. Vol 6, No 1 (2007) - Articles In vitro Heparin Precipitation in the Plasma of Euthyroid women with Recurrent Miscarriage and Unexplained Infertility Abstract. ISSN: 1595-8272. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Osei-Bagyina, A. Vol 28, No 2 (2008) - Articles Assessment and Management of Articulation and Phonological Disorders in School Children in Ghana Abstract PDF. ISSN: 0855-0395. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's ...

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    Hamisa, M. Vol 51, No 3 (2015) - Articles Role of Doppler US and MRI in diagnosis of placenta accreta. Abstract PDF. ISSN: 2090-2948. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact ...

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    Korah, TE. Vol 50, No 3 (2014) - Articles Role of serum glypican-3 in the diagnosis and differentiation of small hepatocellular carcinoma from hepatitis-C virus cirrhosis. Abstract PDF. ISSN: 2090-2948. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about ...

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    Widyawaruyanti, A. Vol 4, No 3 (2007) - Articles Apoptosis Inducing Effect Of Andrographolide On TF-47 Human Breast Cancer Cell Line Abstract PDF. ISSN: 0189-6016. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

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    Jordaan, JC. Vol 17, No 3 (2013) - Articles Impact of interest rate changes on South African GDP and households: a combined macroeconomic and social accounting matrix modelling approach. Abstract PDF. ISSN: 1998-8125. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

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    Aniley, B. Vol 1, No 2 (2010) - Articles Service quality attributes affecting passengers' satisfaction with HIGER city bus. Abstract PDF. ISSN: 2410-2393. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Chakraborty, Shankar. Vol 4, No 2 (2012) - Articles A modified principal component analysis-based utility theory approach for optimization of correlated responses of EDM process. Abstract PDF. ISSN: 2141-2839. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More ...

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    Isa, E.D.M.. Vol 9, No 6S (2017) - Articles Silica coated ionic liquid templated mesoporous silica nanoparticles. Abstract PDF. ISSN: 1112-9867. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

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    Mahapatra, S. Vol 2, No 5 (2010) - Articles Modeling, simulation and parametric optimization of wire EDM process using response surface methodology coupled with grey-Taguchi technique. Abstract PDF. ISSN: 2141-2839. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors ...

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    Omokhudu, OO. Vol 2, No 1 (2011) - Articles International Convergence of Accounting Standards: Issues and Challenges Abstract. ISSN: 2141-4343. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...