Sample records for region ventrolateral part
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Neurons responsive to face-view in the primate ventrolateral prefrontal cortex.
Romanski, L M; Diehl, M M
2011-08-25
Studies have indicated that temporal and prefrontal brain regions process face and vocal information. Face-selective and vocalization-responsive neurons have been demonstrated in the ventrolateral prefrontal cortex (VLPFC) and some prefrontal cells preferentially respond to combinations of face and corresponding vocalizations. These studies suggest VLPFC in nonhuman primates may play a role in communication that is similar to the role of inferior frontal regions in human language processing. If VLPFC is involved in communication, information about a speaker's face including identity, face-view, gaze, and emotional expression might be encoded by prefrontal neurons. In the following study, we examined the effect of face-view in ventrolateral prefrontal neurons by testing cells with auditory, visual, and a set of human and monkey faces rotated through 0°, 30°, 60°, 90°, and -30°. Prefrontal neurons responded selectively to either the identity of the face presented (human or monkey) or to the specific view of the face/head, or to both identity and face-view. Neurons which were affected by the identity of the face most often showed an increase in firing in the second part of the stimulus period. Neurons that were selective for face-view typically preferred forward face-view stimuli (0° and 30° rotation). The neurons which were selective for forward face-view were also auditory responsive compared to other neurons which responded to other views or were unselective which were not auditory responsive. Our analysis showed that the human forward face (0°) was decoded better and also contained the most information relative to other face-views. Our findings confirm a role for VLPFC in the processing and integration of face and vocalization information and add to the growing body of evidence that the primate ventrolateral prefrontal cortex plays a prominent role in social communication and is an important model in understanding the cellular mechanisms of communication
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Burles, Ford; Slone, Edward; Iaria, Giuseppe
2017-04-01
The retrosplenial complex is a region within the posterior cingulate cortex implicated in spatial navigation. Here, we investigated the functional specialization of this large and anatomically heterogeneous region using fMRI and resting-state functional connectivity combined with a spatial task with distinct phases of spatial 'updating' (i.e., integrating and maintaining object locations in memory during spatial displacement) and 'orienting' (i.e., recalling unseen locations from current position in space). Both spatial 'updating' and 'orienting' produced bilateral activity in the retrosplenial complex, among other areas. However, spatial 'updating' produced slightly greater activity in ventro-lateral portions, of the retrosplenial complex, whereas spatial 'orienting' produced greater activity in a more dorsal and medial portion of it (both regions localized along the parieto-occipital fissure). At rest, both ventro-lateral and dorso-medial subregions of the retrosplenial complex were functionally connected to the hippocampus and parahippocampus, regions both involved in spatial orientation and navigation. However, the ventro-lateral subregion of the retrosplenial complex displayed more positive functional connectivity with ventral occipital and temporal object recognition regions, whereas the dorso-medial subregion activity was more correlated to dorsal activity and frontal activity, as well as negatively correlated with more ventral parietal structures. These findings provide evidence for a dorso-medial to ventro-lateral functional specialization within the human retrosplenial complex that may shed more light on the complex neural mechanisms underlying spatial orientation and navigation in humans.
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The physiological role of AT1 receptors in the ventrolateral medulla
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T. Tagawa
2000-06-01
Full Text Available Neurons in the rostral and caudal parts of the ventrolateral medulla (VLM play a pivotal role in the regulation of sympathetic vasomotor activity and blood pressure. Studies in several species, including humans, have shown that these regions contain a high density of AT1 receptors specifically associated with neurons that regulate the sympathetic vasomotor outflow, or the secretion of vasopressin from the hypothalamus. It is well established that specific activation of AT1 receptors by application of exogenous angiotensin II in the rostral and caudal VLM excites sympathoexcitatory and sympathoinhibitory neurons, respectively, but the physiological role of these receptors in the normal synaptic regulation of VLM neurons is not known. In this paper we review studies which have defined the effects of specific activation or blockade of these receptors on cardiovascular function, and discuss what these findings tell us with regard to the physiological role of AT1 receptors in the VLM in the tonic and phasic regulation of sympathetic vasomotor activity and blood pressure.
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Suzuki, Atsunobu; Ito, Yuichi; Kiyama, Sachiko; Kunimi, Mitsunobu; Ohira, Hideki; Kawaguchi, Jun; Tanabe, Hiroki C; Nakai, Toshiharu
2016-01-01
A bad reputation can persistently affect judgments of an individual even when it turns out to be invalid and ought to be disregarded. Such indelible distrust may reflect that the negative evaluation elicited by a bad reputation transfers to a person. Consequently, the person him/herself may come to activate this negative evaluation irrespective of the accuracy of the reputation. If this theoretical model is correct, an evaluation-related brain region will be activated when witnessing a person whose bad reputation one has learned about, regardless of whether the reputation is deemed valid or not. Here, we tested this neural hypothesis with functional magnetic resonance imaging (fMRI). Participants memorized faces paired with either a good or a bad reputation. Next, they viewed the faces alone and inferred whether each person was likely to cooperate, first while retrieving the reputations, and then while trying to disregard them as false. A region of the left ventrolateral prefrontal cortex (vlPFC), which may be involved in negative evaluation, was activated by faces previously paired with bad reputations, irrespective of whether participants attempted to retrieve or disregard these reputations. Furthermore, participants showing greater activity of the left ventrolateral prefrontal region in response to the faces with bad reputations were more likely to infer that these individuals would not cooperate. Thus, once associated with a bad reputation, a person may elicit evaluation-related brain responses on their own, thereby evoking distrust independently of their reputation.
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Qiao, L; Wei, D T; Li, W F; Chen, Q L; Che, X W; Li, B B; Li, Y D; Qiu, J; Zhang, Q L; Liu, Y J
2013-01-01
Individuals have different levels of stress sensitivity. An individual's predisposition to experience negative life events (NLEs) may make him/her more vulnerable to a series of psychopathological and physical diseases. However, the neuroanatomical correlates of individual differences in sensitivity to NLEs remain unknown. In this study, voxel-based morphometry was used to identify the gray matter (GM) associations of individual differences in sensitivity to NLEs measured by adolescent self-rating life events checklist. Results showed that there was a positive association between individual NLEs sensitivity and regional GM volume (rGMV) in the ventrolateral prefrontal cortex (VLPFC). GM was mostly evident in the left frontal operculum and a small part of the left middle frontal gyrus. This region was thought to play an important role in introception. Importantly, our study revealed that rumination served as a mediator between the rGMV of the VLPFC and individual NLEs sensitivity. These findings suggest that people with greater VLPFC might be more inclined to ruminate and the ruminative response style might make them more sensitive to NLEs. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
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Gao, J X; Liu, L
1990-10-01
In urethane-anesthetized, vagotomized and paralyzed rabbits, effects of electrical stimulation of the dorso-medial area of the nucleus facialis (DMNF) on the respiration-related units (RRUs) in ventro-lateral region of nucleus tractus solitaris (VLNTS) were observed. The experimental results showed that during electrical stimulation of DMNF the majority of the inspiratory (I) neurons (64.4%) were increased in frequency and duration of discharge, some to a marked extent. During electrical stimulation of DMNF the expiratory neurons (35%) were decreased in their frequency and duration of discharge, some to a marked extent too. The responses of RRUs in ipsilateral and contralateral VLNTS to stimulation of DMNF was not statistically significant (P greater than 0.05). It is suggested that DMNF may have a facilitating effect on the inspiratory neurons and an inhibiting effect on the expiratory neurons in VLNTS.
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Davies, A; Lumsden, A
1983-01-01
Trigeminal ganglia have been removed from five, six, seven and eight day chick embryos and explants of the dorso-medial (DM) and ventro-lateral (VL) parts of the maxillomandibular lobe were grown in tissue culture. Quantitative methods were used to assess the influence of nerve growth factor (NGF) on fiber outgrowth from these explants. At all ages outgrowth from DM explants was significantly greater than from VL explants, the difference being most pronounced between the extreme DM and VL poles of the maxillomandibular lobe. These observations are interpreted as indicating the existence of two distinct populations of neurons in terms of their response to NGF rather than the consequence of the asynchronous differentiation and maturation of the VL and DM neurons. A similar study of 10, 11 and 12 day embryonic mouse trigeminal ganglia revealed no significant difference in neurite outgrowth between DM and VL regions grown in the presence or absence of NGF. Copyright © 1983. Published by Elsevier Ltd.
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Electrophysiological evidence for spatiotemporal flexibility in the ventrolateral attention network.
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Jelena Ristic
Full Text Available Successful completion of many everyday tasks depends on interactions between voluntary attention, which acts to maintain current goals, and reflexive attention, which enables responding to unexpected events by interrupting the current focus of attention. Past studies, which have mostly examined each attentional mechanism in isolation, indicate that volitional and reflexive orienting depend on two functionally specialized cortical networks in the human brain. Here we investigated how the interplay between these two cortical networks affects sensory processing and the resulting overt behavior. By combining measurements of human performance and electrocortical recordings with a novel analytical technique for estimating spatiotemporal activity in the human cortex, we found that the subregions that comprise the reflexive ventrolateral attention network dissociate both spatially and temporally as a function of the nature of the sensory information and current task demands. Moreover, we found that together with the magnitude of the early sensory gain, the spatiotemporal neural dynamics accounted for the high amount of the variance in the behavioral data. Collectively these data support the conclusion that the ventrolateral attention network is recruited flexibly to support complex behaviors.
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Similar or different? The role of the ventrolateral prefrontal cortex in similarity detection.
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Béatrice Garcin
Full Text Available Patients with frontal lobe syndrome can exhibit two types of abnormal behaviour when asked to place a banana and an orange in a single category: some patients categorize them at a concrete level (e.g., "both have peel", while others continue to look for differences between these objects (e.g., "one is yellow, the other is orange". These observations raise the question of whether abstraction and similarity detection are distinct processes involved in abstract categorization, and that depend on separate areas of the prefrontal cortex (PFC. We designed an original experimental paradigm for a functional magnetic resonance imaging (fMRI study involving healthy subjects, confirming the existence of two distinct processes relying on different prefrontal areas, and thus explaining the behavioural dissociation in frontal lesion patients. We showed that: 1 Similarity detection involves the anterior ventrolateral PFC bilaterally with a right-left asymmetry: the right anterior ventrolateral PFC is only engaged in detecting physical similarities; 2 Abstraction per se activates the left dorsolateral PFC.
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Sugihara, Tadashi; Diltz, Mark D; Averbeck, Bruno B; Romanski, Lizabeth M
2006-10-25
The integration of auditory and visual stimuli is crucial for recognizing objects, communicating effectively, and navigating through our complex world. Although the frontal lobes are involved in memory, communication, and language, there has been no evidence that the integration of communication information occurs at the single-cell level in the frontal lobes. Here, we show that neurons in the macaque ventrolateral prefrontal cortex (VLPFC) integrate audiovisual communication stimuli. The multisensory interactions included both enhancement and suppression of a predominantly auditory or a predominantly visual response, although multisensory suppression was the more common mode of response. The multisensory neurons were distributed across the VLPFC and within previously identified unimodal auditory and visual regions (O'Scalaidhe et al., 1997; Romanski and Goldman-Rakic, 2002). Thus, our study demonstrates, for the first time, that single prefrontal neurons integrate communication information from the auditory and visual domains, suggesting that these neurons are an important node in the cortical network responsible for communication.
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VANDERPLAS, J; MAES, FW; BOHUS, B
1995-01-01
Stimulation of sites in the rostral or caudoventral periaqueductal gray (PAG) results in substantial increases in mean blood pressure (MBP) and heart rate (HR). The efferent pathways from these PAG subregions possibly include a relay in the ventrolateral medulla oblongata (VLM), where neurons
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Coding of vocalizations by single neurons in ventrolateral prefrontal cortex.
Plakke, Bethany; Diltz, Mark D; Romanski, Lizabeth M
2013-11-01
Neuronal activity in single prefrontal neurons has been correlated with behavioral responses, rules, task variables and stimulus features. In the non-human primate, neurons recorded in ventrolateral prefrontal cortex (VLPFC) have been found to respond to species-specific vocalizations. Previous studies have found multisensory neurons which respond to simultaneously presented faces and vocalizations in this region. Behavioral data suggests that face and vocal information are inextricably linked in animals and humans and therefore may also be tightly linked in the coding of communication calls in prefrontal neurons. In this study we therefore examined the role of VLPFC in encoding vocalization call type information. Specifically, we examined previously recorded single unit responses from the VLPFC in awake, behaving rhesus macaques in response to 3 types of species-specific vocalizations made by 3 individual callers. Analysis of responses by vocalization call type and caller identity showed that ∼19% of cells had a main effect of call type with fewer cells encoding caller. Classification performance of VLPFC neurons was ∼42% averaged across the population. When assessed at discrete time bins, classification performance reached 70 percent for coos in the first 300 ms and remained above chance for the duration of the response period, though performance was lower for other call types. In light of the sub-optimal classification performance of the majority of VLPFC neurons when only vocal information is present, and the recent evidence that most VLPFC neurons are multisensory, the potential enhancement of classification with the addition of accompanying face information is discussed and additional studies recommended. Behavioral and neuronal evidence has shown a considerable benefit in recognition and memory performance when faces and voices are presented simultaneously. In the natural environment both facial and vocalization information is present simultaneously and
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Parker, Lindsay M; Le, Sheng; Wearne, Travis A; Hardwick, Kate; Kumar, Natasha N; Robinson, Katherine J; McMullan, Simon; Goodchild, Ann K
2017-06-15
Previous studies have demonstrated that a range of stimuli activate neurons, including catecholaminergic neurons, in the ventrolateral medulla. Not all catecholaminergic neurons are activated and other neurochemical content is largely unknown hence whether stimulus specific populations exist is unclear. Here we determine the neurochemistry (using in situ hybridization) of catecholaminergic and noncatecholaminergic neurons which express c-Fos immunoreactivity throughout the rostrocaudal extent of the ventrolateral medulla, in Sprague Dawley rats treated with hydralazine or saline. Distinct neuronal populations containing PPCART, PPPACAP, and PPNPY mRNAs, which were largely catecholaminergic, were activated by hydralazine but not saline. Both catecholaminergic and noncatecholaminergic neurons containing preprotachykinin and prepro-enkephalin (PPE) mRNAs were also activated, with the noncatecholaminergic population located in the rostral C1 region. Few GlyT2 neurons were activated. A subset of these data was then used to compare the neuronal populations activated by 2-deoxyglucose evoked glucoprivation (Brain Structure and Function (2015) 220:117). Hydralazine activated more neurons than 2-deoxyglucose but similar numbers of catecholaminergic neurons. Commonly activated populations expressing PPNPY and PPE mRNAs were defined. These likely include PPNPY expressing catecholaminergic neurons projecting to vasopressinergic and corticotrophin releasing factor neurons in the paraventricular nucleus, which when activated result in elevated plasma vasopressin and corticosterone. Stimulus specific neurons included noncatecholaminergic neurons and a few PPE positive catecholaminergic neuron but neurochemical codes were largely unidentified. Reasons for the lack of identification of stimulus specific neurons, readily detectable using electrophysiology in anaesthetized preparations and for which neural circuits can be defined, are discussed. © 2017 Wiley Periodicals, Inc.
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International Nuclear Information System (INIS)
Underwood, M.D.
1988-01-01
Neurons within the rostral ventrolateral medulla (RVL) corresponding to the location of adrenaline neurons of the C1 group (C1 area) maintain resting levels of arterial pressure (AP) and mediate the reflex cardiovascular responses to baro- and chemoreceptor activation and cerebral ischemia. The author therefore sought to determine whether neurons in the C1 area: (a) modulate regional cerebral blood flow (rCBF) and/or cerebral glucose utilization (rCGU), (b) participate in the maintenance of resting levels of CBF and CGU, and (c) mediate the CBF response to hypoxia. Rats were anesthetized, paralyzed and ventilated. The RVL was stimulated electrically or chemically, with kainic acid; lesions were placed electrolytically. rCBF was measured using 14-C-iodoantipyrine and rCGU with 14 C-2-deoxyglucose in 11 dissected brain regions
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Chung, Hui-Kuan; Tymula, Agnieszka; Glimcher, Paul
2017-12-06
The population of people above 65 years old continues to grow, and there is mounting evidence that as humans age they are more likely to make errors. However, the specific effect of neuroanatomical aging on the efficiency of economic decision-making is poorly understood. We used whole-brain voxel-based morphometry analysis to determine where reduction of gray matter volume in healthy female and male adults over the age of 65 years correlates with a classic measure of economic irrationality: violations of the Generalized Axiom of Revealed Preference. All participants were functionally normal with Mini-Mental State Examination scores ranging between 26 and 30. While our elders showed the previously reported decline in rationality compared with younger subjects, chronological age per se did not correlate with rationality measures within our population of elders. Instead, reduction of gray matter density in ventrolateral prefrontal cortex correlates tightly with irrational behavior. Interestingly, using a large fMRI sample and meta-analytic tool with Neurosynth, we found that this brain area shows strong coactivation patterns with nearly all of the value-associated regions identified in previous studies. These findings point toward a neuroanatomic locus for economic rationality in the aging brain and highlight the importance of understanding both anatomy and function in the study of aging, cognition, and decision-making. SIGNIFICANCE STATEMENT Age is a crucial factor in decision-making, with older individuals making more errors in choices. Using whole-brain voxel-based morphometry analysis, we found that reduction of gray matter density in ventrolateral prefrontal cortex correlates with economic irrationality: reduced gray matter volume in this area correlates with the frequency and severity of violations of the Generalized Axiom of Revealed Preference. Furthermore, this brain area strongly coactivates with other reward-associated regions identified with Neurosynth
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Szabó, István; Hormay, Edina; Csetényi, Bettina; Nagy, Bernadett; Lénárd, László; Karádi, Zoltán
2018-02-01
Multiple functional attributes of glucose-monitoring neurons in the medial orbitofrontal (ventrolateral prefrontal) cortex. NEUROSCI BIOBEHAV REV 73(1) XXX-XXX, 2017.- Special chemosensory cells, the glucose-monitoring (GM) neurons, reportedly involved in the central feeding control, exist in the medial orbitofrontal (ventrolateral prefrontal) cortex (mVLPFC). Electrophysiological, metabolic and behavioral studies reveal complex functional attributes of these cells and raise their homeostatic significance. Single neuron recordings, by means of the multibarreled microelectrophoretic technique, elucidate differential sensitivities of limbic forebrain neurons in the rat and the rhesus monkey to glucose and other chemicals, whereas gustatory stimulations demonstrate their distinct taste responsiveness. Metabolic examinations provide evidence for alteration of blood glucose level in glucose tolerance test and elevation of plasma triglyceride concentration after destruction of the local GM cells by streptozotocin (STZ). In behavioral studies, STZ microinjection into the mVLPFC fails to interfere with the acquisition of saccharin conditioned taste avoidance, does cause, however, taste perception deficit in taste reactivity tests. Multiple functional attributes of GM neurons in the mVLPFC, within the frame of the hierarchically organized central GM neuronal network, appear to play important role in the maintenance of the homeostatic balance. Copyright © 2017 Elsevier Ltd. All rights reserved.
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Responses of medial and ventrolateral prefrontal cortex to interpersonal conflict for resources
Koban, Leonie; Pichon, Swann; Vuilleumier, Patrik
2014-01-01
Little is known about brain mechanisms recruited during the monitoring and appraisal of social conflicts—for instance, when individuals compete with each other for the same resources. We designed a novel experimental task inducing resource conflicts between two individuals. In an event-related functional magnetic resonance imaging (fMRI) design, participants played with another human participant or against a computer, who across trials chose either different (no-conflict) or the same tokens (conflict trials) in order to obtain monetary gains. In conflict trials, the participants could decide whether they would share the token, and the resulting gain, with the other person or instead keep all points for themselves. Behaviorally, participants shared much more often when playing with a human partner than with a computer. fMRI results demonstrated that the dorsal mediofrontal cortex was selectively activated during human conflicts. This region might play a key role in detecting situations in which self- and social interest are incompatible and require behavioral adjustment. In addition, we found a conflict-related response in the right ventrolateral prefrontal cortex that correlated with measures of social relationship and individual sharing behavior. Taken together, these findings reveal a key role of these prefrontal areas for the appraisal and resolution of interpersonal resource conflicts. PMID:23460073
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Responses of medial and ventrolateral prefrontal cortex to interpersonal conflict for resources.
Koban, Leonie; Pichon, Swann; Vuilleumier, Patrik
2014-05-01
Little is known about brain mechanisms recruited during the monitoring and appraisal of social conflicts--for instance, when individuals compete with each other for the same resources. We designed a novel experimental task inducing resource conflicts between two individuals. In an event-related functional magnetic resonance imaging (fMRI) design, participants played with another human participant or against a computer, who across trials chose either different (no-conflict) or the same tokens (conflict trials) in order to obtain monetary gains. In conflict trials, the participants could decide whether they would share the token, and the resulting gain, with the other person or instead keep all points for themselves. Behaviorally, participants shared much more often when playing with a human partner than with a computer. fMRI results demonstrated that the dorsal mediofrontal cortex was selectively activated during human conflicts. This region might play a key role in detecting situations in which self- and social interest are incompatible and require behavioral adjustment. In addition, we found a conflict-related response in the right ventrolateral prefrontal cortex that correlated with measures of social relationship and individual sharing behavior. Taken together, these findings reveal a key role of these prefrontal areas for the appraisal and resolution of interpersonal resource conflicts.
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Egner, Tobias
2013-01-01
Conflict adaptation – a conflict-triggered improvement in the resolution of conflicting stimulus or response representations – has become a widely used probe of cognitive control processes in both healthy and clinical populations. Previous functional magnetic resonance imaging (fMRI) studies have localized activation foci associated with conflict resolution to dorsolateral prefrontal cortex (dlPFC). The traditional group-analysis approach employed in these studies highlights regions that are, on average, activated during conflict resolution, but does not necessarily reveal areas mediating individual differences in conflict resolution, because between-subject variance is treated as noise. Here, we employed a complementary approach in order to elucidate the neural bases of variability in the proficiency of conflict-driven cognitive control. We analyzed two independent fMRI data sets of face-word Stroop tasks by using individual variability in the behavioral expression of conflict adaptation as the metric against which brain activation was regressed, while controlling for individual differences in mean reaction time and Stroop interference. Across the two experiments, a replicable neural substrate of individual variation in conflict adaptation was found in ventrolateral prefrontal cortex (vlPFC), specifically, in the right inferior frontal gyrus, pars orbitalis (BA 47). Unbiased regression estimates showed that variability in activity in this region accounted for ~40% of the variance in behavioral expression of conflict adaptation across subjects, thus documenting a heretofore unsuspected key role for vlPFC in mediating conflict-driven adjustments in cognitive control. We speculate that vlPFC plays a primary role in conflict control that is supplemented by dlPFC recruitment under conditions of suboptimal performance. PMID:21568631
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Ryan Parsons
2010-08-01
Full Text Available Recent work has led to a better understanding of the neural mechanisms underlying the extinction of Pavlovian fear conditioning. Long-term synaptic changes in the medial prefrontal cortex (mPFC are critical for extinction learning, but very little is currently known about how the mPFC and other brain areas interact during extinction. The current study examined the effect of drugs that impair the extinction of fear conditioning on the activation of the extracellular-related kinase/mitogen-activated protein kinase (ERK/MAPK in brain regions that likely participate in the consolidation of extinction learning. Inhibitors of opioid and N-methyl-D-aspartic acid (NMDA receptors were applied to the ventrolateral periaqueductal gray matter (vlPAG and amygdala shortly before extinction training. Results from these experiments show that blocking opioid receptors in the vlPAG prevented the formation of extinction memory, whereas NMDA receptor blockade had no effect. Conversely, blocking NMDA receptors in the amygdala disrupted the formation of fear extinction memory, but opioid receptor blockade in the same brain area did not. Subsequent experiments tested the effect of these drug treatments on the activation of the ERK/MAPK signaling pathway in various brain regions following extinction training. Only opioid receptor blockade in the vlPAG disrupted ERK phosphorylation in the mPFC and amygdala. These data support the idea that opiodergic signaling derived from the vlPAG affects plasticity across the brain circuit responsible for the formation of extinction memory.
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Padley, James R; Li, Qun; Pilowsky, Paul M; Goodchild, Ann K
2003-01-01
The nature of the cardiorespiratory effects mediated by cannabinoids in the hindbrain is poorly understood. In the present study we investigated whether cannabinoid receptor activation in the rostral ventrolateral medulla oblongata (RVLM) affects cardiovascular and/or respiratory function. Initially, we looked for evidence of CB1 receptor gene expression in rostral and caudal sections of the rat ventrolateral medulla (VLM) using reverse transcription–polymerase chain reaction. Second, the potent cannabinoid receptor agonists WIN55,212-2 (0.05, 0.5 or 5 pmol per 50 nl) and HU-210 (0.5 pmol per 50 nl) or the CB1 receptor antagonist/inverse agonist AM281 (1 pmol per 100 nl) were microinjected into the RVLM of urethane-anaesthetised, immobilised and mechanically ventilated male Sprague–Dawley rats (n=22). Changes in splanchnic nerve activity (sSNA), phrenic nerve activity (PNA), mean arterial pressure (MAP) and heart rate (HR) in response to cannabinoid administration were recorded. The CB1 receptor gene was expressed throughout the VLM. Unilateral microinjection of WIN55,212-2 into the RVLM evoked short-latency, dose-dependent increases in sSNA (0.5 pmol; 175±8%, n=5) and MAP (0.5 pmol; 26±3%, n=8) and abolished PNA (0.5 pmol; duration of apnoea: 5.4±0.4 s, n=8), with little change in HR (P<0.005). HU-210, structurally related to Δ9-tetrahydrocannabinol (THC), evoked similar effects when microinjected into the RVLM (n=4). Surprisingly, prior microinjection of AM281 produced agonist-like effects, as well as significantly attenuated the response to subsequent injection of WIN55,212-2 (0.5 pmol, n=4). The present study reveals CB1 receptor gene expression in the rat VLM and demonstrates sympathoexcitation, hypertension and respiratory inhibition in response to RVLM-administered cannabinoids. These findings suggest a novel link between CB1 receptors in this region of the hindbrain and the central cardiorespiratory effects of cannabinoids. The extent to which these
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Estrogens modulate ventrolateral ventromedial hypothalamic glucose-inhibited neurons
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Ammy M. Santiago
2016-10-01
Full Text Available Objective: Brain regulation of glucose homeostasis is sexually dimorphic; however, the impact sex hormones have on specific neuronal populations within the ventromedial hypothalamic nucleus (VMN, a metabolically sensitive brain region, has yet to be fully characterized. Glucose-excited (GE and -inhibited (GI neurons are located throughout the VMN and may play a critical role in glucose and energy homeostasis. Within the ventrolateral portion of the VMN (VL-VMN, glucose sensing neurons and estrogen receptor (ER distributions overlap. We therefore tested the hypothesis that VL-VMN glucose sensing neurons were sexually dimorphic and regulated by 17β-estradiol (17βE. Methods: Electrophysiological recordings of VL-VMN glucose sensing neurons in brain slices isolated from age- and weight-matched female and male mice were performed in the presence and absence of 17βE. Results: We found a new class of VL-VMN GI neurons whose response to low glucose was transient despite continued exposure to low glucose. Heretofore, we refer to these newly identified VL-VMN GI neurons as ‘adapting’ or AdGI neurons. We found a sexual dimorphic response to low glucose, with male nonadapting GI neurons, but not AdGI neurons, responding more robustly to low glucose than those from females. 17βE blunted the response of both nonadapting GI and AdGI neurons to low glucose in both males and females, which was mediated by activation of estrogen receptor β and inhibition of AMP-activated kinase. In contrast, 17βE had no impact on GE or non-glucose sensing neurons in either sex. Conclusion: These data suggest sex differences and estrogenic regulation of VMN hypothalamic glucose sensing may contribute to the sexual dimorphism in glucose homeostasis. Author Video: Author Video Watch what authors say about their articles Keywords: 17β-estradiol, AMP-activated kinase, Glucose excited neurons, Glucose inhibited neurons, Ventromedial hypothalamic nucleus, Sexual dimorphism
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Karolina M. Lukasik
2018-01-01
Full Text Available The effects of transcranial direct current stimulation (tDCS on dorsolateral prefrontal cortex functions, such as working memory (WM, have been examined in a number of studies. However, much less is known about the behavioral effects of tDCS over other important WM-related brain regions, such as the ventrolateral prefrontal cortex (VLPFC. In a counterbalanced within-subjects design with 33 young healthy participants, we examined whether online and offline single-session tDCS over VLPFC affects WM updating performance as measured by a digit 3-back task. We compared three conditions: anodal, cathodal and sham. We observed no significant tDCS effects on participants' accuracy or reaction times during or after the stimulation. Neither did we find any differences between anodal and cathodal stimulation. Largely similar results were obtained when comparing subgroups of high- and low-performing participants. Possible reasons for the lack of effects, including individual differences in responsiveness to tDCS, features of montage, task and sample characteristics, and the role of VLPFC in WM, are discussed.
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Clarke, Hannah F; Horst, Nicole K; Roberts, Angela C
2015-03-31
Dysregulation of the orbitofrontal and ventrolateral prefrontal cortices is implicated in anxiety and mood disorders, but the specific contributions of each region are unknown, including how they gate the impact of threat on decision making. To address this, the effects of GABAergic inactivation of these regions were studied in marmoset monkeys performing an instrumental approach-avoidance decision-making task that is sensitive to changes in anxiety. Inactivation of either region induced a negative bias away from punishment that could be ameliorated with anxiolytic treatment. However, whereas the effects of ventrolateral prefrontal cortex inactivation on punishment avoidance were seen immediately, those of orbitofrontal cortex inactivation were delayed and their expression was dependent upon an amygdala-anterior hippocampal circuit. We propose that these negative biases result from deficits in attentional control and punishment prediction, respectively, and that they provide the basis for understanding how distinct regional prefrontal dysregulation contributes to the heterogeneity of anxiety disorders with implications for cognitive-behavioral treatment strategies.
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Zhang, Zhaoqiang; Shi, Limin; Du, Xixun; Jiao, Qian; Jiang, Hong
2017-09-01
The degeneration of the rostral ventrolateral medulla (RVLM) catecholaminergic neurons was responsible for some cardiovascular symptoms in Parkinson's disease (PD). Our previous study had observed the impairment of these neurons in the early stage of PD in the rotenone-induced PD rat model, but the related mechanisms remain unclear. Rotenone is a mitochondrial inhibitor, influencing the neuronal electrophysiological activity through activation of K-ATP channels that potentially participate in cell death processes. In the present study, effects of rotenone on electrophysiological properties of RVLM catecholaminergic neurons and its underlying mechanisms were investigated. In coronal slices of brain containing the RVLM through patch clamp technique, rotenone (0.5μM) induced gradual postsynaptic inhibition on the spontaneous firing and cell membrane hyperpolarization with outward currents of catecholaminergic neurons. The electrophysiological changes were blocked by glibenclamide (30μM), a blocker of K-ATP channels, and were nearly unchanged by diazoxide (100μM), an opener of K-ATP channels. Our results also showed that effects of rotenone on catecholaminergic neurons including reactive oxygen species (ROS) generation were prevented by pretreatment of coenzyme Q10 (CoQ10, 100μM), a scavenger of ROS. These suggest that rotenone-induced electrophysiological changes of RVLM catecholaminergic neurons are caused by the opening of K-ATP channels, which are partly related to ROS generation. The changes of K-ATP channels might account for the vulnerability of RVLM catecholaminergic neurons. Copyright © 2017 Elsevier Inc. All rights reserved.
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Benarroch, E. E.; Smithson, I. L.; Low, P. A.; Parisi, J. E.
1998-01-01
The ventrolateral portion of the intermediate reticular formation of the medulla (ventrolateral medulla, VLM), including the C1/A1 groups of catecholaminergic neurons, is thought to be involved in control of sympathetic cardiovascular outflow, cardiorespiratory interactions, and reflex control of vasopressin release. As all these functions are affected in patients with multiple systems atrophy (MSA) with autonomic failure, we sought to test the hypothesis that catecholaminergic (tyrosine hydroxylase [TH]-positive) neurons of the VLM are depleted in these patients. Medullas were obtained at autopsy from 4 patients with MSA with prominent autonomic failure and 5 patients with no neurological disease. Patients with MSA had laboratory evidence of severe adrenergic sudomotor and cardiovagal failure. Tissue was immersion fixed in 2% paraformaldehyde at 4 degrees C for 24 hours and cut into 1-cm blocks in the coronal plane from throughout the medulla. Serial 50-microm sections were collected and one section every 300 microm was stained for TH. There was a pronounced depletion of TH neurons in the rostral VLM in all cases of MSA. There was also significant reduction of TH neurons in the caudal VLM in 3 MSA patients compared with 3 control subjects. In 2 MSA cases and in 2 control subjects, the thoracic spinal cord was available for study. There was also depletion of TH fibers and sympathetic preganglionic neurons (SPNs) in the 2 MSA cases examined. Thus, depletion of catecholaminergic neurons in the VLM may provide a substrate for some of the autonomic and endocrine manifestations of MSA.
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Suprachiasmatic modulation of noradrenaline release in the ventrolateral preoptic nucleus.
Saint-Mleux, Benoît; Bayer, Laurence; Eggermann, Emmanuel; Jones, Barbara E; Mühlethaler, Michel; Serafin, Mauro
2007-06-13
As the major brain circadian pacemaker, the suprachiasmatic nucleus (SCN) is known to influence the timing of sleep and waking. We thus investigated here the effect of SCN stimulation on neurons of the ventrolateral preoptic nucleus (VLPO) thought to be involved in promoting sleep. Using an acute in vitro preparation of the rat anterior hypothalamus/preoptic area, we found that whereas single-pulse stimulations of the SCN evoked standard fast ionotropic IPSPs and EPSPs, train stimulations unexpectedly evoked a long-lasting inhibition (LLI). Such LLIs could also be evoked in VLPO neurons by pressure application of NMDA within the SCN, indicating the specific activation of SCN neurons. This LLI was shown to result from the presynaptic facilitation of noradrenaline release, because it was suppressed in presence of yohimbine, a selective antagonist of alpha2-adrenoreceptors. The LLI depended on the opening of a potassium conductance, because it was annulled at E(K) and could be reversed below E(K). These results show that the SCN can provide an LLI of the sleep-promoting VLPO neurons that could play a role in the circadian organization of the sleep-waking cycle.
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Kitta, Takeya; Mitsui, Takahiko; Kanno, Yukiko; Chiba, Hiroki; Moriya, Kimihiko; Yoshioka, Mitsuhiro; Shinohara, Nobuo
2016-01-01
Objectives: To elucidate the possible involvement of glutamate and serotonin (5-hydroxytryptamine) neurons in the ventrolateral midbrain periaqueductal gray during noxious stimulation. Methods: The study was carried out by evoking a noxious stimulation by acetic acid in an animal model of cystitis. Changes in glutamate and 5-hydroxytryptamine in the periaqueductal gray during the micturition reflex and acetic acid-induced cystitis were determined using in vivo microdialysis combined with cyst...
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49 CFR Appendix B to Part 37 - FTA Regional Offices
2010-10-01
... 49 Transportation 1 2010-10-01 2010-10-01 false FTA Regional Offices B Appendix B to Part 37 Transportation Office of the Secretary of Transportation TRANSPORTATION SERVICES FOR INDIVIDUALS WITH DISABILITIES (ADA) Pt. 37, App. B Appendix B to Part 37—FTA Regional Offices Region I, Federal Transit...
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Wiech, K; Jbabdi, S; Lin, C S; Andersson, J; Tracey, I
2014-10-01
Functional neuroimaging studies suggest that the anterior, mid, and posterior division of the insula subserve different functions in the perception of pain. The anterior insula (AI) has predominantly been associated with cognitive-affective aspects of pain, while the mid and posterior divisions have been implicated in sensory-discriminative processing. We examined whether this functional segregation is paralleled by differences in (1) structural and (2) resting state connectivity and (3) in correlations with pain-relevant psychological traits. Analyses were restricted to the 3 insular subdivisions and other pain-related brain regions. Both type of analyses revealed largely overlapping results. The AI division was predominantly connected to the ventrolateral prefrontal cortex (structural and resting state connectivity) and orbitofrontal cortex (structural connectivity). In contrast, the posterior insula showed strong connections to the primary somatosensory cortex (SI; structural connectivity) and secondary somatosensory cortex (SII; structural and resting state connectivity). The mid insula displayed a hybrid connectivity pattern with strong connections with the ventrolateral prefrontal cortex, SII (structural and resting state connectivity) and SI (structural connectivity). Moreover, resting state connectivity revealed strong connectivity of all 3 subdivisions with the thalamus. On the behavioural level, AI structural connectivity was related to the individual degree of pain vigilance and awareness that showed a positive correlation with AI-amygdala connectivity and a negative correlation with AI-rostral anterior cingulate cortex connectivity. In sum, our findings show a differential structural and resting state connectivity for the anterior, mid, and posterior insula with other pain-relevant brain regions, which might at least partly explain their different functional profiles in pain processing. Copyright © 2014 The Authors. Published by Elsevier B.V. All
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Directory of Open Access Journals (Sweden)
Silva N.F.
2002-01-01
Full Text Available Pressor responses elicited by stimulation of the nucleus raphe obscurus (NRO depend on the integrity of the rostral ventrolateral medulla (RVLM. Therefore, to test the participation of excitatory amino acid (EAA receptors in the cardiovascular responses evoked by NRO stimulation (1 ms, 100 Hz, 40-70 µA, for 10 s, the EAA antagonist kynurenic acid (Kyn was microinjected at different sites in the ventrolateral medullar surface (2.7 nmol/200 nl of male Wistar rats (270-320 g, N = 39 and NRO stimulation was repeated. The effects of NRO stimulation were: hypertension (deltaMAP = +43 ± 1 mmHg, P<0.01, bradycardia (deltaHR = -30 ± 7 bpm, P<0.01 and apnea. Bilateral microinjection of Kyn into the RVLM, which did not change baseline parameters, almost abolished the bradycardia induced by NRO stimulation (deltaHR = -61 ± 3 before vs -2 ± 3 bpm after Kyn, P<0.01, N = 7. Unilateral microinjection of Kyn into the CVLM did not change baseline parameters or reduce the pressor response to NRO stimulation (deltaMAP = +46 ± 5 before vs +48 ± 5 mmHg after Kyn, N = 6. Kyn bilaterally microinjected into the caudal pressor area reduced blood pressure and heart rate and almost abolished the pressor response to NRO stimulation (deltaMAP = +46 ± 4 mmHg before vs +4 ± 2 mmHg after Kyn, P<0.01, N = 7. These results indicate that EAA receptors on the medullary ventrolateral surface play a role in the modulation of the cardiovascular responses induced by NRO stimulation, and also suggest that the RVLM participates in the modulation of heart rate responses and that the caudal pressor area modulates the pressor response following NRO stimulation.
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Directory of Open Access Journals (Sweden)
Jun Chen
Full Text Available Hypocretin/orexin-producing neurons, located in the perifornical region of the lateral hypothalamus area (LHA and projecting to the brain sites of rostral ventrolateral medulla (RVLM, involve in the increase of sympathetic activity, thereby regulating cardiovascular function. The current study was designed to test the hypothesis that the central orexin-A (OXA could be involved in the cardiovascular dysfunction of acute myocardial infarction (AMI by releasing NAD(PH oxidase-derived superoxide anion (O2 (- generation in RVLM, AMI rat model established by ligating the left anterior descending (LAD coronary artery to induce manifestation of cardiac dysfunction, monitored by the indicators as heart rate (HR, heart rate variability (HRV, mean arterial pressure (MAP and left intraventricular pressure. The results showed that the expressions of OXA in LHA and orexin 1 receptor (OX1R increased in RVLM of AMI rats. The double immunofluorescent staining indicated that OX1R positive cells and NAD(PH oxidative subunit gp91phox or p47phox-immunoreactive (IR cells were co-localized in RVLM. Microinjection of OXA into the cerebral ventricle significantly increased O2 (- production and mRNA expression of NAD(PH oxidase subunits when compared with aCSF-treated ones. Exogenous OXA administration in RVLM produced pressor and tachycardiac effects. Furthermore, the antagonist of OX1R and OX2R (SB-408124 and TCS OX2 29, respectively or apocynin (APO, an inhibitor of NAD(PH oxidase, partly abolished those cardiovascular responses of OXA. HRV power spectral analysis showed that exogenous OXA led to decreased HF component of HRV and increased LF/HF ratio in comparison with aCSF, which suggested that OXA might be related to sympathovagal imbalance. As indicated by the results, OXA might participate in the central regulation of cardiovascular activities by disturbing the sympathovagal balance in AMI, which could be explained by the possibility that OXR and NAD(PH-derived O
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DEFF Research Database (Denmark)
Bhatt, Deepak K; Ramachandran, Roshni; Christensen, Sarah Louise Tangsgaard
2015-01-01
caudalis (TNC) was isolated at different time points after CGRP infusion. The level of c-Fos mRNA and protein expression in TNC were analyzed by qPCR and immunohistochemistry. c-Fos-stained nuclei were also counted in the nucleus tractus solitarius (NTS) and caudal ventrolateral medulla (CVLM), integrative...
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Szabó, Ádám György; Farkas, Kinga; Marosi, Csilla; Kozák, Lajos R; Rudas, Gábor; Réthelyi, János; Csukly, Gábor
2017-12-08
Schizophrenia has a negative effect on the activity of the temporal and prefrontal cortices in the processing of emotional facial expressions. However no previous research focused on the evaluation of mixed emotions in schizophrenia, albeit they are frequently expressed in everyday situations and negative emotions are frequently expressed by mixed facial expressions. Altogether 37 subjects, 19 patients with schizophrenia and 18 healthy control subjects were enrolled in the study. The two study groups did not differ in age and education. The stimulus set consisted of 10 fearful (100%), 10 happy (100%), 10 mixed fear (70% fear and 30% happy) and 10 mixed happy facial expressions. During the fMRI acquisition pictures were presented in a randomized order and subjects had to categorize expressions by button press. A decreased activation was found in the patient group during fear, mixed fear and mixed happy processing in the right ventrolateral prefrontal cortex (VLPFC) and the right anterior insula (RAI) at voxel and cluster level after familywise error correction. No difference was found between study groups in activations to happy facial condition. Patients with schizophrenia did not show a differential activation between mixed happy and happy facial expression similar to controls in the right dorsolateral prefrontal cortex (DLPFC). Patients with schizophrenia showed decreased functioning in right prefrontal regions responsible for salience signaling and valence evaluation during emotion recognition. Our results indicate that fear and mixed happy/fear processing are impaired in schizophrenia, while happy facial expression processing is relatively intact.
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DEFF Research Database (Denmark)
Hervig, Mona E; Thomsen, Morten S; Kalló, Imre
2016-01-01
and thalamus of rats. A single dose of PCP (10mg/kg, s.c.) significantly increased total number of c-Fos-IR in: (1) the prelimbic, infralimbic, anterior cingulate, ventrolateral orbital, motor, somatosensory and retrosplenial cortices as well as the nucleus accumbens (NAc), field CA1 of the hippocampus (CA1......) field of hippocampus and mediodorsal thalamus (MD); (2) PV-IR cells in the ventrolateral orbitofrontal and retrosplenial cortices and CA1 field of hippocampus; and (3) CB-IR cells in the motor cortex. Overall, our data indicate that PCP activates a wide range of cortical and subcortical brain regions...... and subcortical areas, but whether such induction occurs in specific populations of GABAergic interneuron subtypes still remains to be established. We performed an immunohistochemical analysis of the PCP-induced c-Fos-immunoreactivity (IR) in parvalbumin (PV) and calbindin (CB) interneuron subtypes in the cortex...
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Goldstein, Kim E; Hazlett, Erin A; Savage, Kimberley R; Berlin, Heather A; Hamilton, Holly K; Zelmanova, Yuliya; Look, Amy E; Koenigsberg, Harold W; Mitsis, Effie M; Tang, Cheuk Y; McNamara, Margaret; Siever, Larry J; Cohen, Barry H; New, Antonia S
2011-04-15
Schizotypal personality disorder (SPD) individuals and borderline personality disorder (BPD) individuals have been reported to show neuropsychological impairments and abnormalities in brain structure. However, relationships between neuropsychological function and brain structure in these groups are not well understood. This study compared visual-spatial working memory (SWM) and its associations with dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) gray matter volume in 18 unmedicated SPD patients with no BPD traits, 18 unmedicated BPD patients with no SPD traits, and 16 healthy controls (HC). Results showed impaired SWM in SPD but not BPD, compared with HC. Moreover, among the HC group, but not SPD patients, better SWM performance was associated with larger VLPFC (BA44/45) gray matter volume (Fisher's Z p-values <0.05). Findings suggest spatial working memory impairments may be a core neuropsychological deficit specific to SPD patients and highlight the role of VLPFC subcomponents in normal and dysfunctional memory performance. Published by Elsevier B.V.
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Yanagisawa, Kuniaki; Abe, Nobuhito; Kashima, Emiko S; Nomura, Michio
2016-03-01
Reminders of death often elicit defensive responses in individuals, especially among those with low self-esteem. Although empirical evidence indicates that self-esteem serves as a buffer against mortality threats, the precise neural mechanism underlying this effect remains unknown. We used functional magnetic resonance imaging (fMRI) to test the hypothesis that self-esteem modulates neural responses to death-related stimuli, especially functional connectivity within the limbic-frontal circuitry, thereby affecting subsequent defensive reactions. As predicted, individuals with high self-esteem subjected to a mortality threat exhibited increased amygdala-ventrolateral prefrontal cortex (VLPFC) connectivity during the processing of death-related stimuli compared with individuals who have low self-esteem. Further analysis revealed that stronger functional connectivity between the amygdala and the VLPFC predicted a subsequent decline in responding defensively to those who threaten one's beliefs. These results suggest that the amygdala-VLPFC interaction, which is modulated by self-esteem, can reduce the defensiveness caused by death-related stimuli, thereby providing a neural explanation for why individuals with high self-esteem exhibit less defensive reactions to mortality threats. (c) 2016 APA, all rights reserved).
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Sugiyama, Yoichiro; Suzuki, Takeshi; Yates, Bill J
2011-05-01
Research on animal models as well as human subjects has demonstrated that the vestibular system contributes to regulating the distribution of blood in the body through effects on the sympathetic nervous system. Elimination of vestibular inputs results in increased blood flow to the hindlimbs during vestibular stimulation, because it attenuates the increase in vascular resistance that ordinarily occurs in the lower body during head-up tilts. Additionally, the changes in vascular resistance produced by vestibular stimulation differ between body regions. Electrical stimulation of vestibular afferents produces an inhibition of most hindlimb vasoconstrictor fibers and a decrease in hindlimb vascular resistance, but an initial excitation of most upper body vasoconstrictor fibers accompanied by an increase in upper body vascular resistance. The present study tested the hypothesis that neurons in the principal vasomotor region of the brainstem, the rostral ventrolateral medulla (RVLM), whose projections extended past the T10 segment, to spinal levels containing sympathetic preganglionic neurons regulating lower body blood flow, respond differently to electrical stimulation of the vestibular nerve than RVLM neurons whose axons terminate rostral to T10. Contrary to our hypothesis, the majority of RVLM neurons were excited by vestibular stimulation, despite their level of projection in the spinal cord. These findings indicate that the RVLM is not solely responsible for establishing the patterning of vestibular-sympathetic responses. This patterning apparently requires the integration by spinal circuitry of labyrinthine signals transmitted from the brainstem, likely from regions in addition to the RVLM.
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Audio-vocal interaction in single neurons of the monkey ventrolateral prefrontal cortex.
Hage, Steffen R; Nieder, Andreas
2015-05-06
Complex audio-vocal integration systems depend on a strong interconnection between the auditory and the vocal motor system. To gain cognitive control over audio-vocal interaction during vocal motor control, the PFC needs to be involved. Neurons in the ventrolateral PFC (VLPFC) have been shown to separately encode the sensory perceptions and motor production of vocalizations. It is unknown, however, whether single neurons in the PFC reflect audio-vocal interactions. We therefore recorded single-unit activity in the VLPFC of rhesus monkeys (Macaca mulatta) while they produced vocalizations on command or passively listened to monkey calls. We found that 12% of randomly selected neurons in VLPFC modulated their discharge rate in response to acoustic stimulation with species-specific calls. Almost three-fourths of these auditory neurons showed an additional modulation of their discharge rates either before and/or during the monkeys' motor production of vocalization. Based on these audio-vocal interactions, the VLPFC might be well positioned to combine higher order auditory processing with cognitive control of the vocal motor output. Such audio-vocal integration processes in the VLPFC might constitute a precursor for the evolution of complex learned audio-vocal integration systems, ultimately giving rise to human speech. Copyright © 2015 the authors 0270-6474/15/357030-11$15.00/0.
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Golanov, E. V.; Reis, D. J.
1996-01-01
1. We sought to determine whether hypoxic stimulation of neurons of the rostral ventrolateral reticular nucleus (RVL) would elevate regional cerebral blood flow (rCBF) in anaesthetized paralysed rats. 2. Microinjection of sodium cyanide (NaCN; 150-450 pmol) into the RVL rapidly (within 1-2 s), transiently, dose-dependently and site-specifically elevated rCBF1 measured by laser Doppler flowmetry, by 61.3 +/- 22.1% (P < 0.01), increased arterial pressure (AP; +30 +/- 8 mmHg; P < 0.01)1 and triggered a synchronized 6 Hz rhythm of EEG activity. 3. Following cervical spinal cord transection, NaCN and also dinitrophenol (DNP) significantly (P < 0.05) elevated rCBF and synchronized the EEG but did not elevate AP; the response to NaCN was attenuated by hyperoxia and deepening of anaesthesia. 4. Electrical stimulation of NaCN-sensitive sites in the RVL in spinalized rats increased rCBF measured autoradiographically with 14C iodoantipyrine (Kety method) in the mid-line thalamus (by 182.3 +/- 17.2%; P < 0.05) and cerebral cortex (by 172.6 +/- 15.6%; P < 0.05) regions, respectively, directly or indirectly innervated by RVL neurons, and in the remainder of the brain. In contrast regional cerebral glucose utilization (rCGU), measured autoradiographically with 14C-2-deoxyglucose (Sokoloff method), was increased in proportion to rCBF in the mid-line thalamus (165.6 +/- 17.8%, P < 0.05) but was unchanged in the cortex. 5. Bilateral electrolytic lesions of NaCN sensitive sites of RVL, while not altering resting rCBF or the elevation elicited by hypercarbia (arterial CO2 pressure, Pa,CO2, approximately 69 mmHg), reduced the vasodilatation elicited by normocapnic hypoxaemia (arterial O2 pressure, Pa,O2, approximately 27 mmHg) by 67% (P < 0.01) and flattened the slope of the Pa,O2-rCBF response curve. 6. We conclude that the elevation of rCBF produced in the cerebral cortex by hypoxaemia is in large measure neurogenic, mediated trans-synaptically over intrinsic neuronal pathways, and
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Orexins excite ventrolateral geniculate nucleus neurons predominantly via OX2 receptors.
Chrobok, Lukasz; Palus, Katarzyna; Lewandowski, Marian Henryk
2016-04-01
Orexins/hypocretins are two neuropeptides that influence many behaviours, such as feeding, sleep or arousal. Orexin A/hypocretin-1 (OXA) and orexin B/hypocretin-2 (OXB) bind to two metabotropic receptors, named the OX1 and OX2 receptors. The lateral geniculate complex of the thalamus is one of the many targets of orexinergic fibres derived from the lateral hypothalamus, although the impact of orexins on the ventrolateral geniculate nucleus (VLG) is poorly understood. The VLG, an important relay station of the subcortical visual system, is implicated in visuomotor and/or circadian processes. Therefore, in this study we evaluated the effects of orexins on single VLG neurons using a patch-clamp technique in vitro. Surprisingly, orexins depolarised the majority of the recorded neurons regardless of their localisation in the borders of the VLG. In addition, data presented in this article show that neurons synthesising NO were also affected by OXA. Moreover, immunohistochemical staining of OXB revealed the moderate density of orexinergic fibbers in the VLG. Our study using specific orexin receptor antagonists suggests that the OX2 receptor has a dominant role in the observed effects of OXA. To our knowledge, this article is the first to show orexinergic modulation of the VLG. These findings strengthen the postulated link between orexins and the circadian system, and propose a new role of these neuropeptides in the modulation of visuomotor functions. Copyright © 2015 Elsevier Ltd. All rights reserved.
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Radiological assistance program: Region I. Part I
International Nuclear Information System (INIS)
Musolino, S.V.; Kuehner, A.V.; Hull, A.P.
1985-01-01
The purpose of the Radiological Assistance Program (RAP) is to make DOE resources available and provide emergency assistance to state and local agencies in order to control radiological hazards, protect the public health and safety, and minimize the loss of property. This plan is an integral part of a nationwide program of radiological assistance established by the US DOE, and is implemented on a regional basis. The Brookhaven Area Office (BHO) Radiological Assistance Program is applicable to DOE Region I, which consists of the New England States, New York, New Jersey, Pennsylvania, Delaware, Maryland and the District of Columbia. The BHO RAP-1 has been developed to: (a) ensure the availability of an effective radiological assistance capability to ensure the protection of persons and property; (b) provide guidelines to RAP-1 Team personnel for the evaluation of radiological incidents and implementation of corrective actions; (c) maintain liaison with other DOE installations, Federal, State and local organizations which may become involved in radiological assistance operations in Region I; and (d) encourage development of a local capability to cope with radiological incidents
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Garell, P C; Bakken, H; Greenlee, J D W; Volkov, I; Reale, R A; Oya, H; Kawasaki, H; Howard, M A; Brugge, J F
2013-10-01
The connection between auditory fields of the temporal lobe and prefrontal cortex has been well characterized in nonhuman primates. Little is known of temporofrontal connectivity in humans, however, due largely to the fact that invasive experimental approaches used so successfully to trace anatomical pathways in laboratory animals cannot be used in humans. Instead, we used a functional tract-tracing method in 12 neurosurgical patients with multicontact electrode arrays chronically implanted over the left (n = 7) or right (n = 5) perisylvian temporal auditory cortex (area PLST) and the ventrolateral prefrontal cortex (VLPFC) of the inferior frontal gyrus (IFG) for diagnosis and treatment of medically intractable epilepsy. Area PLST was identified by the distribution of average auditory-evoked potentials obtained in response to simple and complex sounds. The same sounds evoked little if there is any activity in VLPFC. A single bipolar electrical pulse (0.2 ms, charge-balanced) applied between contacts within physiologically identified PLST resulted in polyphasic evoked potentials clustered in VLPFC, with greatest activation being in pars triangularis of the IFG. The average peak latency of the earliest negative deflection of the evoked potential on VLPFC was 13.48 ms (range: 9.0-18.5 ms), providing evidence for a rapidly conducting pathway between area PLST and VLPFC.
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Chiou, Rocco; Lambon Ralph, Matthew A
2018-04-01
Working memory (WM) is a buffer that temporarily maintains information, be it visual or auditory, in an active state, caching its contents for online rehearsal or manipulation. How the brain enables long-term semantic knowledge to affect the WM buffer is a theoretically significant issue awaiting further investigation. In the present study, we capitalise on the knowledge about famous individuals as a 'test-case' to study how it impinges upon WM capacity for human faces and its neural substrate. Using continuous theta-burst transcranial stimulation combined with a psychophysical task probing WM storage for varying contents, we provide compelling evidence that (1) faces (regardless of familiarity) continued to accrue in the WM buffer with longer encoding time, whereas for meaningless stimuli (colour shades) there was little increment; (2) the rate of WM accrual was significantly more efficient for famous faces, compared to unknown faces; (3) the right anterior-ventrolateral temporal lobe (ATL) causally mediated this superior WM storage for famous faces. Specifically, disrupting the ATL (a region tuned to semantic knowledge including person identity) selectively hinders WM accrual for celebrity faces while leaving the accrual for unfamiliar faces intact. Further, this 'semantically-accelerated' storage is impervious to disruption of the right middle frontal gyrus and vertex, supporting the specific and causative contribution of the right ATL. Our finding advances the understanding of the neural architecture of WM, demonstrating that it depends on interaction with long-term semantic knowledge underpinned by the ATL, which causally expands the WM buffer when visual content carries semantic information. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.
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Directory of Open Access Journals (Sweden)
Tatsuya eKobayashi
2015-02-01
Full Text Available Sexual behavior is suppressed by various types of stressors. We previously demonstrated that an alarm pheromone released by stressed male Wistar rats is a stressor to other rats, increases the number of mounts needed for ejaculation, and decreases the hit rate (described as the number of intromissions/sum of the mounts and intromissions. This deterioration in sexual behavior was ameliorated by pretreatment with the opioid receptor antagonist naloxone. However, the neural mechanism underlying this remains to be elucidated. Here, we examined Fos expression in 31 brain regions of pheromone-exposed rats and naloxone-pretreated pheromone-exposed rats 60 min after 10 intromissions. As previously reported, the alarm pheromone increased the number of mounts and decreased the hit rate. In addition, Fos expression was increases in the anterior medial division, anterior lateral division and posterior division of the bed nucleus of the stria terminalis, parvocellular part of the paraventricular nucleus of the hypothalamus, arcuate nucleus, dorsolateral and ventrolateral periaqueductal gray, and nucleus paragigantocellularis. Fos expression decreased in the magnocellular part of the paraventricular nucleus of the hypothalamus. Pretreatment with naloxone blocked the pheromone-induced changes in Fos expression in the magnocellular part of the paraventricular nucleus of the hypothalamus, ventrolateral periaqueductal gray, and nucleus paragigantocellularis. Based on these results, we hypothesize that the alarm pheromone deteriorated sexual behavior by activating the ventrolateral periaqueductal gray-nucleus paragigantocellularis cluster and suppressing the magnocellular part of the paraventricular nucleus of the hypothalamus via the opioidergic pathway.
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Major Thought Restructuring: The Roles of Different Prefrontal Cortical Regions.
Seyed-Allaei, Shima; Avanaki, Zahra Nasiri; Bahrami, Bahador; Shallice, Tim
2017-07-01
An important question for understanding the neural basis of problem solving is whether the regions of human prefrontal cortices play qualitatively different roles in the major cognitive restructuring required to solve difficult problems. However, investigating this question using neuroimaging faces a major dilemma: either the problems do not require major cognitive restructuring, or if they do, the restructuring typically happens once, rendering repeated measurements of the critical mental process impossible. To circumvent these problems, young adult participants were challenged with a one-dimensional Subtraction (or Nim) problem [Bouton, C. L. Nim, a game with a complete mathematical theory. The Annals of Mathematics, 3, 35-39, 1901] that can be tackled using two possible strategies. One, often used initially, is effortful, slow, and error-prone, whereas the abstract solution, once achieved, is easier, quicker, and more accurate. Behaviorally, success was strongly correlated with sex. Using voxel-based morphometry analysis controlling for sex, we found that participants who found the more abstract strategy (i.e., Solvers) had more gray matter volume in the anterior medial, ventrolateral prefrontal, and parietal cortices compared with those who never switched from the initial effortful strategy (i.e., Explorers). Removing the sex covariate showed higher gray matter volume in Solvers (vs. Explorers) in the right ventrolateral prefrontal and left parietal cortex.
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Objects Mediate Goal Integration in Ventrolateral Prefrontal Cortex during Action Observation.
Directory of Open Access Journals (Sweden)
Mari Hrkać
Full Text Available Actions performed by others are mostly not observed in isolation, but embedded in sequences of actions tied together by an overarching goal. Therefore, preceding actions can modulate the observer's expectations in relation to the currently perceived action. Ventrolateral prefrontal cortex (vlPFC, and inferior frontal gyrus (IFG in particular, is suggested to subserve the integration of episodic as well as semantic information and memory, including action scripts. The present fMRI study investigated if activation in IFG varies with the effort to integrate expected and observed action, even when not required by the task. During an fMRI session, participants were instructed to attend to short videos of single actions and to deliver a judgment about the actor's current goal. We manipulated the strength of goal expectation induced by the preceding action, implementing the parameter "goal-relatedness" between the preceding and the currently observed action. Moreover, since objects point to the probability of certain actions, we also manipulated whether the current and the preceding action shared at least one object or not. We found an interaction between the two factors goal-relatedness and shared object: IFG activation increased the weaker the goal-relatedness between the preceding and the current action was, but only when they shared at least one object. Here, integration of successive action steps was triggered by the re-appearing (shared object but hampered by a weak goal-relatedness between the actually observed manipulation. These findings foster the recently emerging view that IFG is enhanced by goal-related conflicts during action observation.
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Directory of Open Access Journals (Sweden)
Zilli eHuma
2014-04-01
Full Text Available Bulbospinal systems (BS originate from various regions of the brainstem and influence spinal neurons by classical synaptic and modulatory mechanisms. Our aim was to determine the brainstem locations of cells of origin of BS pathways passing through the medial longitudinal fasciculus (MLF and the caudal ventrolateral medulla (CVLM. We also examined the transmitter content of spinal terminations of the CVLM pathway. Six adult rats received Fluorogold (FG injections to the right intermediate grey matter of the lumbar cord (L1-L2 and the b-subunit of cholera toxin (CTb was injected either into the MLF or the right CVLM (3 animals each. Double-labelled cells were identified within brainstem structures with confocal microscopy and mapped onto brainstem diagrams. An additional 3 rats were injected with CTb in the CVLM to label axon terminals in the lumbar spinal cord. Double-labelled cells projecting via the MLF or CVLM were found principally in reticular regions of the medulla and pons but small numbers of cells were also located within the midbrain. CVLM projections to the lumbar cord were almost exclusively ipsilateral and concentrated within the intermediate grey matter. Most (62% of terminals were immunoreactive for the vesicular glutamate transporter 2 while 23% contained the vesicular GABA transporter. The inhibitory subpopulation was glycinergic, GABAergic or contained both transmitters. The proportions of excitatory and inhibitory axons projecting via the CVLM to the lumbar cord are similar to those projecting via the MLF. Unlike the MLF pathway, CVLM projections are predominantly ipsilateral and concentrated within intermediate grey but do not extend into motor nuclei or laminia VIII. Terminations of the CVLM pathway are located in a region of the grey matter that is rich in premotor interneurons; thus its primary function may be to coordinate activity of premotor networks.
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Zhang, Cheng-Rong; Xia, Chun-Mei; Jiang, Mei-Yan; Zhu, Min-Xia; Zhu, Ji-Min; Du, Dong-Shu; Liu, Min; Wang, Jin; Zhu, Da-Nian
2013-08-01
Studies have revealed that apelin is a novel multifunctional peptide implicated both in blood pressure (BP) regulation and cardiac function control. Evidence shows that apelin and its receptor (APJ) in the rostral ventrolateral medulla (RVLM) may play an important role in central BP regulation; however, its role is controversial and very few reports have shown the relationship between acupuncture and apelin. Our study aims to both investigate the apelinergic system role in stress-induced hypertension (SIH) and determine whether acupuncture therapy effects on hypertension involve the apelinergic system in the RVLM. We established the stress-induced hypertensive rat (SIHR) model using electric foot-shock stressors with noise interventions. The expression of both apelin and the APJ receptor in the RVLM neurons was examined by immunohistochemical staining and Western blots. The results showed apelin expression increased remarkably in SIHR while APJ receptor expression showed no significant difference between control and SIHR groups. Microinjection of apelin-13 into the RVLM of control rats or SIHR produced pressor and tachycardic effects. Furthermore, effects induced by apelin-13 in SIHR were significantly greater than those of control rats. In addition, repetitive electroacupuncture (EA) stimulation at the Zusanli (ST-36) acupoint attenuated hypertension and apelin expression in the RVLM in SIHR; it also attenuated the pressor effect elicited by exogenous apelin-13 microinjection in SIHR. The results suggest that augmented apelin in the RVLM was part of the manifestations of SIH; the antihypertensive effects of EA might be associated with the attenuation of apelin expression and function in the RVLM, which might be a novel role for EA in SIH setting. Copyright © 2013 Elsevier Inc. All rights reserved.
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Regional climate change: Precipitation variability in mountainous part of Bulgaria
Directory of Open Access Journals (Sweden)
Nikolova Nina
2007-01-01
Full Text Available The aim of paper is to analyze temporal and spatial changes in monthly precipitation as well as extremely dry and wet months in mountainous part of Bulgaria. Study precipitation variability in mountainous part is very important because this part is the region where the rivers take its source from. Extreme values of monthly precipitation are important information for better understanding of the whole variability and trends in precipitation time series. The mean investigated period is 1951-2005 and the reference period is so called temporary climate - 1961- 1990. Extreme dry precipitation months are defined as a month whose monthly precipitation is lower than 10% of gamma distribution in the reference period 1961-1990. Extreme wet months are determined with respect to 90% percentiles of gamma distribution (monthly precipitation is higher than 90%. The result of the research show that in mountainous part of Bulgaria during 1950s and 1960s number of extremely wet months is higher than number of dry months. Decreasing of monthly precipitation is a feature for 1980s. This dry period continues till 2004. The years 2000 makes impression as driest year in high mountains with about 7 extremely dry months. The second dry year is 1993. The negative precipitation anomaly is most clearly determined during last decade at study area. The present research points out that fluctuation of precipitation in mountainous part of Bulgaria are coinciding with regional and global climate trends.
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Zha, Yan-Ping; Wang, Yang-Kai; Deng, Yu; Zhang, Ru-Wen; Tan, Xing; Yuan, Wen-Jun; Deng, Xiao-Ming; Wang, Wei-Zhong
2013-04-01
It is well known that low-intensity exercise training (ExT) is beneficial to cardiovascular dysfunction in hypertension. The tonically active glutamatergic input to the rostral ventrolateral medulla (RVLM), a key region for control of blood pressure and sympathetic tone, has been demonstrated to be increased in hypertensive rats. The aim of this study was to determine the effect of ExT on the increased glutamatergic input to the RVLM in spontaneously hypertensive rat (SHR). Normotensive rats Wistar-Kyoto (WKY) and SHR were treadmill trained or remained sedentary (Sed) for 12 weeks and classed into four groups (WKY-Sed, WKY-ExT, SHR-Sed, and SHR-ExT). The release of glutamate in the RVLM and its contribution to cardiovascular activity were determined in WKY and SHR after treatment of ExT. Blood pressure and sympathetic tone were significantly reduced in SHR after treatment with ExT. Bilateral microinjection of the glutamate receptor antagonist kynurenic acid (2.7 nmol in 100 nL) into the RVLM significantly decreased resting blood pressure, heart rate, and renal sympathetic nerve activity in SHR-Sed but not in WKY groups (WKY-Sed and WKY-ExT). However, the degree of reduction in these cardiovascular parameters evoked by KYN was significantly blunted in SHR-ExT compared with SHR-Sed group. The concentration of glutamate and the protein expression of vesicular glutamate transporter 2 in the RVLM were significantly increased in SHR-Sed compared with WKY-Sed, whereas they were reduced after treatment with ExT. Our findings suggest that ExT attenuates the enhancement in the tonically acting glutamatergic input to the RVLM of hypertensive rats, thereby reducing the sympathetic hyperactivity and blood pressure. © 2013 Blackwell Publishing Ltd.
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Ortega, Leonardo A; Glueck, Amanda C; Uhelski, Megan; Fuchs, Perry N; Papini, Mauricio R
2013-05-01
The present research evaluated the role of two prefrontal cortex areas, the ventrolateral orbital cortex (VLO) and the medial prefrontal cortex (mPFC), on two situations involving incentive downshifts, consummatory successive negative contrast (cSNC) with sucrose solutions and Pavlovian autoshaping following continuous vs. partial reinforcement with food pellets. Animals received electrolytic lesions and then were tested on cSNC, autoshaping, open-field activity, and sucrose sensitivity. Lesions of the VLO reduced suppression of consummatory behavior after the incentive downshift, but only during the first downshift trial, and also eliminated the enhancement of anticipatory behavior during partial reinforcement, relative to continuous reinforcement, in autoshaping. There was no evidence of specific effects of mPFC lesions on incentive downshifts. Open-field activity was also reduced by VLO lesions, but only in the central area, whereas mPFC lesions had no observable effects on activity. Animals with mPFC lesions exhibited decreased consumption of the lowest sucrose concentration, whereas no effects were observed in animals with VLO lesions. These results suggest that the VLO may exert nonassociative (i.e., motivational, emotional) influences on behavior in situations involving incentive downshifts. No clear role on incentive downshift was revealed by mPFC lesions. Copyright © 2013 Elsevier B.V. All rights reserved.
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Zhou, Yuan; Zhu, Ye; Jiang, Tianzi
2007-05-01
Functional near-infrared spectroscopy (fNIRS) has been used to investigate the changes in the concentration of oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin in brain issue during several cognitive tasks. In the present study, by means of multichannel dual wavelength light-emitting diode continuous-wave (CW) NIRS, we investigated the blood oxygenation changes of prefrontal cortex in 18 healthy subjects while performing a verbal n-back task (0-back and 2-back), which has been rarely investigated by fNIRS. Compared to the 0-back task (control task), we found a significant increase of O2Hb and total amount of hemoglobin (THb) in left and right ventrolateral prefrontal cortex (VLPFC) during the execution of the 2-back task compared to the 0-back task (pdominance. In addition, the effects of gender and its interaction with task performance on O2Hb concentration change were suggested in the present study. Our findings not only confirm that multichannel fNIRS is suitable to detect spatially specific activation during the performance of cognitive tasks; but also suggest that it should be cautious of gender-dependent difference in cerebral activation when interpreting the fNIRS data during cognitive tasks.
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International Nuclear Information System (INIS)
Liu Tengyao; Cui Huanmin; Chen Guoliang; Zhai Yugui
1992-01-01
The western part of Yanliao region is an important uranium metallogenic region. This paper summarizes the regional geophysical model for uranium exploration composed of prediction model for favourable area of mineralization and evaluation model for anomalies on the basis of aeromagnetic and aeroradiometric data interpretation and analysis of the data from carborane and ground gamma spectrometric survey, high accurate magnetic survey, VLF survey and α-collected film survey in mult-displiary research work. The prospective prediction for uranium metallogenesis in this region was also conducted
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Recent Vs. Historical Seismicity Analysis For Banat Seismic Region (Western Part Of Romania)
Oros Eugen; Diaconescu Mihai
2015-01-01
The present day seismic activity from a region reflects the active tectonics and can confirm the seismic potential of the seismogenic sources as they are modelled using the historical seismicity. This paper makes a comparative analysis of the last decade seismicity recorded in the Banat Seismic Region (western part of Romania) and the historical seismicity of the region (Mw≥4.0). Four significant earthquake sequences have been recently localized in the region, three of them nearby the city of...
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Visuotopic organization of the cebus pulvinar: a double representation the contralateral hemifield.
Gattass, R; Oswaldo-Cruz, E; Sousa, A P
1978-08-18
The projection of the visual field in the pulvinar nucleus was studied in 17 Cebus monkeys using electrophysiological techniques. Visual space is represented in two regions of the pulvinar; (1) the ventrolateral group, Pvlg, comprising nuclei P delta, P delta, P gamma, P eta and P mu 1; and (2) P mu. In the first group, which corresponds to the pulvinar inferior and ventral part of the pulvinar lateralis, we observed a greater respresentation of the central part of the visual field. Approximately 58% of the volume of the ventrolateral group is concerned with the visual space within 10 degrees of the fovea. This portion of the visual field is represented at its lateral aspects, mainly close to the level of the caudal pole of the lateral geniculate nucleus (LGN). Projection of the vertical meridian runs along its lateral border while that of the horizontal one is found running from the dorsal third of the LGN's hilus to the medial border of the ventro-lateral group. The lower quadrant is represented at its dorsal portion while the upper quadrant is represented at the ventral one. In Pmu the representation is rotated 90 degrees clockwise around the rostrocaudal axis: the vertical meridian is found at the ventromedial border of this nucleus. Thus, the lower quadrant is represented at the later portion of Pmu and the upper at its medial portion. Both projections are restricted to the contralateral hemifield.
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Energy Technology Data Exchange (ETDEWEB)
Li, Hong-Bao [Department of Physiology and Pathophysiology, Xi' an Jiaotong University Cardiovascular Research Center, Xi' an Jiaotong University School of Medicine, Xi' an 710061 (China); Qin, Da-Nian, E-mail: dnqin@stu.edu.cn [Department of Physiology, Shantou University Medical College, Shantou 515041 (China); Ma, Le [Department of Public Health, Xi' an Jiaotong University School of Medicine, Xi' an 710061 (China); Miao, Yu-Wang [Department of Physiology and Pathophysiology, Xi' an Jiaotong University Cardiovascular Research Center, Xi' an Jiaotong University School of Medicine, Xi' an 710061 (China); Zhang, Dong-Mei [Department of Physiology, Dalian Medical University, Dalian 116044 (China); Lu, Yan [Department of Clinical Laboratory, Sanaitang Hospital, Lanzhou 730030 (China); Song, Xin-Ai [Department of Physiology and Pathophysiology, Xi' an Jiaotong University Cardiovascular Research Center, Xi' an Jiaotong University School of Medicine, Xi' an 710061 (China); Zhu, Guo-Qing [Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing 210029 (China); Kang, Yu-Ming, E-mail: ykang@mail.xjtu.edu.cn [Department of Physiology and Pathophysiology, Xi' an Jiaotong University Cardiovascular Research Center, Xi' an Jiaotong University School of Medicine, Xi' an 710061 (China)
2014-09-01
The hypothalamic paraventricular nucleus (PVN) and rostral ventrolateral medulla (RVLM) play a critical role in the generation and maintenance of sympathetic nerve activity. The renin–angiotensin system (RAS) in the brain is involved in the pathogenesis of hypertension. This study was designed to determine whether inhibition of the angiotensin-converting enzyme (ACE) in the PVN modulates cytokines and attenuates oxidative stress (ROS) in the RVLM, and decreases the blood pressure and sympathetic activity in renovascular hypertensive rats. Renovascular hypertension was induced in male Sprague–Dawley rats by the two-kidney one-clip (2K1C) method. Renovascular hypertensive rats received bilateral PVN infusion with ACE inhibitor lisinopril (LSP, 10 μg/h) or vehicle via osmotic minipump for 4 weeks. Mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and plasma proinflammatory cytokines (PICs) were significantly increased in renovascular hypertensive rats. The renovascular hypertensive rats also had higher levels of ACE in the PVN, and lower level of interleukin-10 (IL-10) in the RVLM. In addition, the levels of PICs, the chemokine MCP-1, the subunit of NAD(P)H oxidase (gp91{sup phox}) and ROS in the RVLM were increased in hypertensive rats. PVN treatment with LSP attenuated those changes occurring in renovascular hypertensive rats. Our findings suggest that the beneficial effects of ACE inhibition in the PVN in renovascular hypertension are partly due to modulation cytokines and attenuation oxidative stress in the RVLM. - Highlights: • Chronic ACE inhibition in PVN on renovascular hypertension was investigated. • 2K1C resulted in sympathoexcitation, increased plasma PICs and hypertension. • 2K1C rats had higher levels of cytokines and reactive oxygen species (ROS) in RVLM. • Chronic inhibiting PVN ACE attenuates cytokines and ROS in RVLM in hypertension.
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International Nuclear Information System (INIS)
Li, Hong-Bao; Qin, Da-Nian; Ma, Le; Miao, Yu-Wang; Zhang, Dong-Mei; Lu, Yan; Song, Xin-Ai; Zhu, Guo-Qing; Kang, Yu-Ming
2014-01-01
The hypothalamic paraventricular nucleus (PVN) and rostral ventrolateral medulla (RVLM) play a critical role in the generation and maintenance of sympathetic nerve activity. The renin–angiotensin system (RAS) in the brain is involved in the pathogenesis of hypertension. This study was designed to determine whether inhibition of the angiotensin-converting enzyme (ACE) in the PVN modulates cytokines and attenuates oxidative stress (ROS) in the RVLM, and decreases the blood pressure and sympathetic activity in renovascular hypertensive rats. Renovascular hypertension was induced in male Sprague–Dawley rats by the two-kidney one-clip (2K1C) method. Renovascular hypertensive rats received bilateral PVN infusion with ACE inhibitor lisinopril (LSP, 10 μg/h) or vehicle via osmotic minipump for 4 weeks. Mean arterial pressure (MAP), renal sympathetic nerve activity (RSNA), and plasma proinflammatory cytokines (PICs) were significantly increased in renovascular hypertensive rats. The renovascular hypertensive rats also had higher levels of ACE in the PVN, and lower level of interleukin-10 (IL-10) in the RVLM. In addition, the levels of PICs, the chemokine MCP-1, the subunit of NAD(P)H oxidase (gp91 phox ) and ROS in the RVLM were increased in hypertensive rats. PVN treatment with LSP attenuated those changes occurring in renovascular hypertensive rats. Our findings suggest that the beneficial effects of ACE inhibition in the PVN in renovascular hypertension are partly due to modulation cytokines and attenuation oxidative stress in the RVLM. - Highlights: • Chronic ACE inhibition in PVN on renovascular hypertension was investigated. • 2K1C resulted in sympathoexcitation, increased plasma PICs and hypertension. • 2K1C rats had higher levels of cytokines and reactive oxygen species (ROS) in RVLM. • Chronic inhibiting PVN ACE attenuates cytokines and ROS in RVLM in hypertension
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Varin, Christophe; Rancillac, Armelle; Geoffroy, Hélène; Arthaud, Sébastien; Fort, Patrice; Gallopin, Thierry
2015-07-08
Sleep-active neurons located in the ventrolateral preoptic nucleus (VLPO) play a crucial role in the induction and maintenance of slow-wave sleep (SWS). However, the cellular and molecular mechanisms responsible for their activation at sleep onset remain poorly understood. Here, we test the hypothesis that a rise in extracellular glucose concentration in the VLPO can promote sleep by increasing the activity of sleep-promoting VLPO neurons. We find that infusion of a glucose concentration into the VLPO of mice promotes SWS and increases the density of c-Fos-labeled neurons selectively in the VLPO. Moreover, we show in patch-clamp recordings from brain slices that VLPO neurons exhibiting properties of sleep-promoting neurons are selectively excited by glucose within physiological range. This glucose-induced excitation implies the catabolism of glucose, leading to a closure of ATP-sensitive potassium (KATP) channels. The extracellular glucose concentration monitors the gating of KATP channels of sleep-promoting neurons, highlighting that these neurons can adapt their excitability according to the extracellular energy status. Together, these results provide evidence that glucose may participate in the mechanisms of SWS promotion and/or consolidation. Although the brain circuitry underlying vigilance states is well described, the molecular mechanisms responsible for sleep onset remain largely unknown. Combining in vitro and in vivo experiments, we demonstrate that glucose likely contributes to sleep onset facilitation by increasing the excitability of sleep-promoting neurons in the ventrolateral preoptic nucleus (VLPO). We find here that these neurons integrate energetic signals such as ambient glucose directly to regulate vigilance states accordingly. Glucose-induced excitation of sleep-promoting VLPO neurons should therefore be involved in the drowsiness that one feels after a high-sugar meal. This novel mechanism regulating the activity of VLPO neurons reinforces the
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The frontal lobes and inhibitory function
International Nuclear Information System (INIS)
Konishi, Seiki
2011-01-01
Neuropsychological studies using traditional tasks of inhibitory functions, such as the Wisconsin card sorting test (WCST) and the Go/No-Go Task have revealed that the frontal lobe is responsible for several types of inhibitory functions. However, the detailed psychological nature of the inhibitory functions and the precise location of their critical foci within the frontal lobe remain to be investigated. Functional magnetic resonance imaging provides spatial and temporal resolution that allowed us to illuminate at least 4 frontal regions involved in inhibitory functions: the dorsolateral, ventrolateral, and rostral parts of the frontal lobe and the presupplementary motor area (preSMA). The ventrolateral part of the frontal lobe in the right hemisphere was activated during response inhibition. The preSMA in the left hemisphere was activated during inhibition of proactive interference immediately after the dimension changes of the WCST. The rostral part of the frontal lobe in the left hemisphere was activated during inhibition long after the dimension changes. The dorsolateral part of the frontal lobe in the left hemisphere was activated at the dimension changes in the first time, but not in the second time. These findings provide clues to our understanding of functional differentiation of inhibitory functions and their localization in the frontal lobe. (author)
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Directory of Open Access Journals (Sweden)
Vladimirov D.R.
2015-10-01
Full Text Available The article is about naturalization features of invasive fraction of flora in Voronezh and some other regions of the European part of Russia. The summary table represents all invasive and potentially invasive plants of the European part of Russia with their level of naturalization (or invasive status. Invasive fraction of flora in the Voronezh region numbers 120 plants. All of them are on different stages of naturalization process in an anthropogenic areal. Invasive plants represent by agriophyts – 41 (34,1 % species, epecophyts – 75 (62,5 % species and colonophyts-epecophyts – 4 (3,4 % species. Totally there are 201 species of invasive and potentially invasive plants spread within European part of Russia (Northern-West Russia, Ivanovo, Kaluga, Tver, and Voronezh regions. They formed the “black list” of European Russia. 10 species are common to all invasive fractions. These are Acer negundo, Amelanchier x spicata, Aster x salignus, Echinocystis lobata, Elodea canadensis, Heracleum sosnowskyi, Impatiens glandulifera, Impatiens parviflora, Juncus tenuis and Lupinus polyphyllus. The analysis of the general list of invasive fractions of European Russia shows that 120 species of the list are invasive or potentially invasive in the Voronezh region (100 and 20 species in accordance, adventives naturalized species – 31, native species – 19, archaeophyts – 2, apophyts – 4. 26 species from the list were not found in the Voronezh region. Apparently, the region is a transit area for many invasive plants, which migrate from South to North, from East to West etc. Not only its natural and climatic potential, but also high level of transformation of local landscapes enabled immigrant-plants to naturalize within the bounds of the region. Furthermore, for many years the Voronezh region was the center of introduction of alien plants. Many of those became a part of invasion fraction of regional flora. In recent decades green building took place of
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Directory of Open Access Journals (Sweden)
Haiyun Yu
2015-01-01
Full Text Available Hydrogen sulfide (H2S plays a crucial role in the regulation of blood pressure and oxidative stress. In the present study, we tested the hypothesis that H2S exerts its cardiovascular effects by reducing oxidative stress via inhibition of NADPH oxidase activity in the rostral ventrolateral medulla (RVLM. We examined cell distributions of cystathionine-β-synthase (CBS and effects of H2S on reactive oxygen species (ROS and mean arterial blood pressure (MAP in spontaneously hypertensive rats (SHRs. We found that CBS was expressed in neurons of the RVLM, and the expression was lower in SHRs than in Wistar-Kyoto rats. Microinjection of NaHS (H2S donor, S-adenosyl-l-methionine (SAM, a CBS agonist, or Apocynin (NADPH oxidase inhibitor into the RVLM reduced the ROS level, NADPH oxidase activity, and MAP, whereas microinjection of hydroxylamine hydrochloride (HA, a CBS inhibitor increased MAP. Furthermore, intracerebroventricular infusion of NaHS inhibited phosphorylation of p47phox, a key step of NADPH oxidase activation. Since decreasing ROS level in the RVLM reduces MAP and heart rate and increasing H2S reduces ROS production, we conclude that H2S exerts an antihypertensive effect via suppressing ROS production. H2S, as an antioxidant, may be a potential target for cardiovascular diseases.
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2010-04-01
... what circumstances may States require Local Boards to take part in regional planning activities? (a... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Under what circumstances may States require Local Boards to take part in regional planning activities? 661.290 Section 661.290 Employees' Benefits...
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Cortico-cortical connections of areas 44 and 45B in the macaque monkey.
Frey, Stephen; Mackey, Scott; Petrides, Michael
2014-04-01
In the human brain, areas 44 and 45 constitute Broca's region, the ventrolateral frontal region critical for language production. The homologues of these areas in the macaque monkey brain have been established by direct cytoarchitectonic comparison with the human brain. The cortical areas that project monosynaptically to areas 44 and 45B in the macaque monkey brain require clarification. Fluorescent retrograde tracers were placed in cytoarchitectonic areas 44 and 45B of the macaque monkey, as well as in the anterior part of the inferior parietal lobule and the superior temporal gyrus. The results demonstrate that ipsilateral afferent connections of area 44 arise from local frontal areas, including rostral premotor cortical area 6, from secondary somatosensory cortex, the caudal insula, and the cingulate motor region. Area 44 is strongly linked with the anterior inferior parietal lobule (particularly area PFG and the adjacent anterior intraparietal sulcus). Input from the temporal lobe is limited to the fundus of the superior temporal sulcus extending caudal to the central sulcus. There is also input from the sulcal part of area Tpt in the upper bank of the superior temporal sulcus. Area 45B shares some of the connections of area 44, but can be distinguished from area 44 by input from the caudal inferior parietal lobule (area PG) and significant input from the part of the superior temporal sulcus that extends anterior to the central sulcus. Area 45B also receives input from visual association cortex that is not observed in area 44. The results have provided a clarification of the relative connections of areas 44 and 45B of the ventrolateral frontal region which, in the human brain, subserves certain aspects of language processing. Copyright © 2013 Elsevier Inc. All rights reserved.
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TROUBLING TIMES-THE GFC AND ITS IMPLICATIONS FOR REGIONAL PERFORMANCE. PART TWO: AUSTRALIA
Robert J. Stimson
2013-01-01
The Global Financial Crisis (GFC) was a profound exogenous shock which has had profound impacts the performance of national economies and the regions within them. The differential outcomes are vast. In many parts of the world there is evidence of what is being referred to as the ‘two-speed’ economy - or even a ‘multi-speed’ - economy. This has implications for regional economic development theory in which, over the last two to three decades, there has been an increasing emphasis on endogenous...
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Bruni, Stefania; Giorgetti, Valentina; Bonini, Luca; Fogassi, Leonardo
2015-08-26
The prefrontal cortex (PFC) is deemed to underlie the complexity, flexibility, and goal-directedness of primates' behavior. Most neurophysiological studies performed so far investigated PFC functions with arm-reaching or oculomotor tasks, thus leaving unclear whether, and to which extent, PFC neurons also play a role in goal-directed manipulative actions, such as those commonly used by primates during most of their daily activities. Here we trained two macaques to perform or withhold grasp-to-eat and grasp-to-place actions, depending on the combination of two subsequently presented cues: an auditory go/no-go cue (high/low tone) and a visually presented target (food/object). By varying the order of presentation of the two cues, we could segment and independently evaluate the processing and integration of contextual information allowing the monkey to make a decision on whether or not to act, and what action to perform. We recorded 403 task-related neurons from the ventrolateral prefrontal cortex (VLPFC): unimodal sensory-driven (37%), motor-related (21%), unimodal sensory-and-motor (23%), and multisensory (19%) neurons. Target and go/no-go selectivity characterized most of the recorded neurons, particularly those endowed with motor-related discharge. Interestingly, multisensory neurons appeared to encode a behavioral decision independently from the sensory modality of the stimulus allowing the monkey to make it: some of them reflected the decision to act or refraining from acting (56%), whereas others (44%) encoded the decision to perform (or withhold) a specific action (e.g., grasp-to-eat). Our findings indicate that VLPFC neurons play a role in the processing of contextual information underlying motor decision during goal-directed manipulative actions. We demonstrated that macaque ventrolateral prefrontal cortex (VLPFC) neurons show remarkable selectivity for different aspects of the contextual information allowing the monkey to select and execute goal
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Directory of Open Access Journals (Sweden)
Jun-Bin eYin
2014-11-01
Full Text Available The periaqueductal gray (PAG modulates nociception via a descending pathway that relays in the rostral ventromedial medulla (RVM and terminates in the spinal cord. Previous behavioral pharmacology and electrophysiological evidence suggests that brain-derived neurotrophic factor (BDNF plays an important role in descending pain modulation, likely through the PAG-RVM pathway. However, there still lacks detailed information on the distribution of BDNF, activation of BDNF-containing neurons projecting to RVM in the condition of pain, and neurochemical properties of these neurons within the PAG. Through fluorescent in situ hybridization (FISH and immunofluorescent staining, the homogenous distributions of BDNF mRNA and protein were observed in the four subregions of PAG. Both neurons and astrocytes expressed BDNF, but not microglias. By combining retrograde tracing methods and formalin pain model, there were more BDNF-containing neurons projecting to RVM being activated in the ventrolateral PAG (vlPAG than other subregions of PAG. The neurochemical properties of BDNF-containing projection neurons in the vlPAG were investigated. BDNF-containing projection neurons expressed auto receptor Tropomyosin-related kinase B (TrkB in addition to serotonin (5-HT, neurotensin (NT, substance P (SP, calcitonin gene related peptide (CGRP, nitric oxide synthase (NOS, and parvalbumin (PV but not tyrosine decarboxylase (TH. It is speculated that BDNF released from projection neurons in the vlPAG might participate in the descending pain modulation through enhancing the presynaptic release of other neuroactive substances (NSs in the RVM.
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Levitt, James J; Nestor, Paul G; Levin, Laura; Pelavin, Paula; Lin, Pan; Kubicki, Marek; McCarley, Robert W; Shenton, Martha E; Rathi, Yogesh
2017-11-01
The striatum receives segregated and integrative white matter tracts from the cortex facilitating information processing in the cortico-basal ganglia network. The authors examined both types of input tracts in the striatal associative loop in chronic schizophrenia patients and healthy control subjects. Structural and diffusion MRI scans were acquired on a 3-T system from 26 chronic schizophrenia patients and 26 matched healthy control subjects. Using FreeSurfer, the associative cortex was parcellated into ventrolateral prefrontal cortex and dorsolateral prefrontal cortex subregions. The striatum was manually parcellated into its associative and sensorimotor functional subregions. Fractional anisotropy and normalized streamlines, an estimate of fiber counts, were assessed in four frontostriatal tracts (dorsolateral prefrontal cortex-associative striatum, dorsolateral prefrontal cortex-sensorimotor striatum, ventrolateral prefrontal cortex-associative striatum, and ventrolateral prefrontal cortex-sensorimotor striatum). Furthermore, these measures were correlated with a measure of cognitive control, the Trail-Making Test, Part B. Results showed reduced fractional anisotropy and fewer streamlines in chronic schizophrenia patients for all four tracts, both segregated and integrative. Post hoc t tests showed reduced fractional anisotropy in the left ventrolateral prefrontal cortex-associative striatum and left ventrolateral prefrontal cortex-sensorimotor striatum and fewer normalized streamlines in the right dorsolateral prefrontal cortex-sensorimotor striatum and in the left and right ventrolateral prefrontal cortex-sensorimotor striatum in chronic schizophrenia patients. Furthermore, normalized streamlines in the right dorsolateral prefrontal cortex-sensorimotor striatum negatively correlated with Trail-Making Test, Part B, time spent in healthy control subjects but not in chronic schizophrenia patients. These findings demonstrated that structural connectivity is
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Pattern of c-Fos expression induced by tail suspension test in the mouse brain
Directory of Open Access Journals (Sweden)
Kentaro Hiraoka
2017-06-01
Full Text Available The tail suspension test (TST has been widely used as a screening assay for antidepressant drugs. However, the neural substrates underlying the stress response and antidepressant-like effect during the TST remain largely unknown despite the prevalence of this test. In the present study, we used immunohistochemistry to examine alterations in c-Fos expression as a measure of neuronal activity in the mouse brain after acute administration of the antidepressant drugs nortriptyline or escitalopram (or saline as a control with or without a subsequent TST session. We found that without the TST session, nortriptyline administration enhanced the density of c-Fos-immunoreactive cells in regions of the central extended amygdala, paraventricular hypothalamic nucleus, and relevant regions of the brain stem, whereas escitalopram did not change c-Fos expression in any region. Following the TST in the absence of antidepressant drugs, we observed a significant increase in c-Fos-positive cell density in a number of brain regions within the limbic telencephalon, hypothalamus, and brain stem. We detected a statistically significant interaction using an analysis of variance between the main effects of the drug and stress response in four regions: the infralimbic cortex, lateral septal nucleus (intermediate part, ventrolateral preoptic nucleus, and solitary nucleus. Following the TST, escitalopram but not nortriptyline increased c-Fos-positive cell density in the infralimbic cortex and ventrolateral preoptic nucleus, whereas nortriptyline but not escitalopram increased c-Fos expression in the solitary nucleus. Both antidepressants significantly increased c-Fos expression in the lateral septal nucleus (intermediate part. The present results indicate that neuronal activity increases in septo-hypothalamic regions and related structures, especially the lateral septal nucleus, following administration of drugs producing an antidepressant-like effect in mice subjected to
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Tummala, Sudhakar; Palomares, Jose; Kang, Daniel W; Park, Bumhee; Woo, Mary A; Harper, Ronald M; Kumar, Rajesh
2016-01-01
Obstructive sleep apnea (OSA) patients show brain structural injury and functional deficits in autonomic, affective, and cognitive regulatory sites, as revealed by mean diffusivity (MD) and other imaging procedures. The time course and nature of gray and white matter injury can be revealed in more detail with mean kurtosis (MK) procedures, which can differentiate acute from chronic injury, and better show extent of damage over MD procedures. Our objective was to examine global and regional MK changes in newly diagnosed OSA, relative to control subjects. Two diffusion kurtosis image series were collected from 22 recently-diagnosed, treatment-naïve OSA and 26 control subjects using a 3.0-Tesla MRI scanner. MK maps were generated, normalized to a common space, smoothed, and compared voxel-by-voxel between groups using analysis of covariance (covariates; age, sex). No age or sex differences appeared, but body mass index, sleep, neuropsychologic, and cognitive scores significantly differed between groups. MK values were significantly increased globally in OSA over controls, and in multiple localized sites, including the basal forebrain, extending to the hypothalamus, hippocampus, thalamus, insular cortices, basal ganglia, limbic regions, cerebellar areas, parietal cortices, ventral temporal lobe, ventrolateral medulla, and midline pons. Multiple sites, including the insular cortices, ventrolateral medulla, and midline pons showed more injury over previously identified damage with MD procedures, with damage often lateralized. Global mean kurtosis values are significantly increased in obstructive sleep apnea (OSA), suggesting acute tissue injury, and these changes are principally localized in critical sites mediating deficient functions in the condition. The mechanisms for injury likely include altered perfusion and hypoxemia-induced processes, leading to acute tissue changes in recently diagnosed OSA. © 2016 Associated Professional Sleep Societies, LLC.
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Vanderperren, Katrien; Raes, Els; Hoegaerts, Michel; Saunders, Jimmy H
2009-02-01
The equine tarsus is the most commonly affected hindlimb region associated with lameness. Diagnostic imaging is routinely applied but because of its complexity, being composed of 10 multifaceted bones and different joints, multiple ligaments, tendons and bursae, imaging this region can be a challenge. This is the first part of a two-part review of the structures and disorders of the equine tarsus. It describes the principal disorders affecting the soft tissues of the tarsal region and addresses some of the technical aspects in taking radiographic, ultrasonographic and scintigraphic images of the different soft tissue lesions. Where applicable, comments on the diagnostic use of contrast radiography, arthroscopy and tenoscopy are made. In current clinical practice a combination of radiography and ultrasonography is still most frequently used to arrive at a diagnosis.
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Recent Vs. Historical Seismicity Analysis For Banat Seismic Region (Western Part Of Romania
Directory of Open Access Journals (Sweden)
Oros Eugen
2015-03-01
Full Text Available The present day seismic activity from a region reflects the active tectonics and can confirm the seismic potential of the seismogenic sources as they are modelled using the historical seismicity. This paper makes a comparative analysis of the last decade seismicity recorded in the Banat Seismic Region (western part of Romania and the historical seismicity of the region (Mw≥4.0. Four significant earthquake sequences have been recently localized in the region, three of them nearby the city of Timisoara (January 2012 and March 2013 and the fourth within Hateg Basin, South Carpathians (October 2013. These sequences occurred within the epicentral areas of some strong historical earthquakes (Mw≥5.0. The main events had some macroseismic effects on people up to some few kilometers from the epicenters. Our results update the Romanian earthquakes catalogue and bring new information along the local seismic hazard sources models and seismotectonics.
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Panteleev, Sergey S; Martseva, Alexandra А; Lyubashina, Olga А
2015-02-15
Irritable bowel syndrome (IBS) is one of the most widespread functional gastrointestinal disorders characterized by abdominal pain. A key pathophysiological mechanism of abdominal pain is associated with disturbances of serotonergic transmission in feedback control loops of endogenous pain modulation in which the ventrolateral medulla (VLM) plays an important role. The receptors to serotonin (5-HT), and particularly the serotonin 3 (5-HT3) receptors have been extensively used as a potential target for abdominal pain treatment of IBS patients due to antinociceptive features of the 5-HT3 receptor antagonists. The precise mechanisms underlying the antinociceptive action of these antagonists remain unclear. The main objective of our study was to evaluate the involvement of the 5-HT3 receptors in abdominal pain transmission within the VLM. Experiments were carried out on urethane-anaesthetized rats using the animal model of abdominal pain. Noxious colorectal distension (CRD) with a pressure of 80mmHg induced a significant increase in VLM neuron-evoked activity and depressor reactions (171.1±12.7% and 64±1.8% to baseline, accordingly). Selective blockade of the 5-HT3 receptors with granisetron at doses of 1.0 or 2.0mg/kg (i.v) resulted in long-lasting (90min) dose-dependent inhibition of VLM neuron-evoked activity and depressor reactions. When brainstem dorsal surface applications of granisetron (10 or 20µM) were used, the changes were more pronounced. These results suggest involvement of the 5-HT3 receptors in abdominal pain transmission within the VLM, which will be discussed in relation to the central antinociceptive effect of granisetron. Copyright © 2015 Elsevier B.V. All rights reserved.
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Kitta, Takeya; Mitsui, Takahiko; Kanno, Yukiko; Chiba, Hiroki; Moriya, Kimihiko; Yoshioka, Mitsuhiro; Shinohara, Nobuo
2016-07-01
To elucidate the possible involvement of glutamate and serotonin (5-hydroxytryptamine) neurons in the ventrolateral midbrain periaqueductal gray during noxious stimulation. The study was carried out by evoking a noxious stimulation by acetic acid in an animal model of cystitis. Changes in glutamate and 5-hydroxytryptamine in the periaqueductal gray during the micturition reflex and acetic acid-induced cystitis were determined using in vivo microdialysis combined with cystometry in rats. Extracellular glutamate levels slightly, but significantly, increased during the micturition reflex induced by saline infusion into the bladder. Intravesical infusion of acetic acid facilitated the micturition reflex characterized by increases in voiding pressure and decreases in the intercontraction interval. Glutamate levels were markedly increased by acetic acid, and this enhancement was sustained for at least 3 h. 5-Hydroxytryptamine levels, which were not altered during the micturition reflex, were increased after intravesical infusion of acetic acid. The results suggest that periaqueductal gray glutamate and 5-hydroxytryptamine neurons differentially participate in the modulation of both nociception and the micturition reflex. Furthermore, periaqueductal gray 5-hydroxytryptamine levels appear to reflect the nociceptive stimuli. © 2016 The Japanese Urological Association.
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40 CFR Appendix Y to Part 51 - Guidelines for BART Determinations Under the Regional Haze Rule
2010-07-01
... Under the Regional Haze Rule Y Appendix Y to Part 51 Protection of Environment ENVIRONMENTAL PROTECTION... improve visibility in certain scenic areas of national importance. The scenic areas protected by section... Organizations, for adoption within each SIP or TIP. 2. The preamble to the 1999 regional haze rule discussed at...
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Marina, Nephtali; Abdala, Ana P.L.; Korsak, Alla; Simms, Annabel E.; Allen, Andrew M.; Paton, Julian F.R.; Gourine, Alexander V.
2011-01-01
Aims Increased sympathetic tone in obstructive sleep apnoea results from recurrent episodes of systemic hypoxia and hypercapnia and might be an important contributor to the development of cardiovascular disease. In this study, we re-evaluated the role of a specific population of sympathoexcitatory catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata in the control of sympathetic vasomotor tone, arterial blood pressure, and hypercapnia-evoked sympathetic and cardiovascular responses. Methods and results In anaesthetized rats in vivo and perfused rat working heart brainstem preparations in situ, C1 neurones were acutely silenced by application of the insect peptide allatostatin following cell-specific targeting with a lentiviral vector to express the inhibitory Drosophila allatostatin receptor. In anaesthetized rats with denervated peripheral chemoreceptors, acute inhibition of 50% of the C1 neuronal population resulted in ∼50% reduction in renal sympathetic nerve activity and a profound fall in arterial blood pressure (by ∼25 mmHg). However, under these conditions systemic hypercapnia still evoked vigorous sympathetic activation and the slopes of the CO2-evoked sympathoexcitatory and cardiovascular responses were not affected by inhibition of C1 neurones. Inhibition of C1 neurones in situ resulted in a reversible fall in perfusion pressure and the amplitude of respiratory-related bursts of thoracic sympathetic nerve activity. Conclusion These data confirm a fundamental physiological role of medullary catecholaminergic C1 neurones in maintaining resting sympathetic vasomotor tone and arterial blood pressure. However, C1 neurones do not appear to mediate sympathoexcitation evoked by central actions of CO2. PMID:21543384
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Miller, Justin Robert; Neumueller, Suzanne; Muere, Clarissa; Olesiak, Samantha; Pan, Lawrence; Hodges, Matthew R.
2013-01-01
A current and major unanswered question is why the highly sensitive central CO2/H+ chemoreceptors do not prevent hypoventilation-induced hypercapnia following carotid body denervation (CBD). Because perturbations involving the carotid bodies affect central neuromodulator and/or neurotransmitter levels within the respiratory network, we tested the hypothesis that after CBD there is an increase in inhibitory and/or a decrease in excitatory neurochemicals within the ventrolateral medullary column (VMC) in awake goats. Microtubules for chronic use were implanted bilaterally in the VMC within or near the pre-Bötzinger Complex (preBötC) through which mock cerebrospinal fluid (mCSF) was dialyzed. Effluent mCSF was collected and analyzed for neurochemical content. The goats hypoventilated (peak +22.3 ± 3.4 mmHg PaCO2) and exhibited a reduced CO2 chemoreflex (nadir, 34.8 ± 7.4% of control ΔV̇E/ΔPaCO2) after CBD with significant but limited recovery over 30 days post-CBD. After CBD, GABA and glycine were above pre-CBD levels (266 ± 29% and 189 ± 25% of pre-CBD; P 0.05) different from control after CBD. Analyses of brainstem tissues collected 30 days after CBD exhibited 1) a midline raphe-specific reduction (P < 0.05) in the percentage of tryptophan hydroxylase–expressing neurons, and 2) a reduction (P < 0.05) in serotonin transporter density in five medullary respiratory nuclei. We conclude that after CBD, an increase in inhibitory neurotransmitters and a decrease in excitatory neuromodulation within the VMC/preBötC likely contribute to the hypoventilation and attenuated ventilatory CO2 chemoreflex. PMID:23869058
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New 20-cm radio-continuum study of the small Magellanic cloud - part III: Compact Hii regions
Directory of Open Access Journals (Sweden)
Wong G.F.
2012-01-01
Full Text Available We present and discuss a new catalogue of 48 compact Hii regions in the Small Magellanic Cloud (SMC and a newly created deep 1420 MHz (λ=20 cm radio-continuum image of the N19 region located in the southwestern part of the SMC. The new images were created by merging 1420 MHz radiocontinuum archival data from the Australian Telescope Compact Array. The majority of these detected radio compact Hii regions have rather flat spectral indices which indicates, as expected, that the dominant emission mechanism is of thermal nature.
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Lelito, Katherine R; Shafer, Orie T
2012-04-01
The relatively simple clock neuron network of Drosophila is a valuable model system for the neuronal basis of circadian timekeeping. Unfortunately, many key neuronal classes of this network are inaccessible to electrophysiological analysis. We have therefore adopted the use of genetically encoded sensors to address the physiology of the fly's circadian clock network. Using genetically encoded Ca(2+) and cAMP sensors, we have investigated the physiological responses of two specific classes of clock neuron, the large and small ventrolateral neurons (l- and s-LN(v)s), to two neurotransmitters implicated in their modulation: acetylcholine (ACh) and γ-aminobutyric acid (GABA). Live imaging of l-LN(v) cAMP and Ca(2+) dynamics in response to cholinergic agonist and GABA application were well aligned with published electrophysiological data, indicating that our sensors were capable of faithfully reporting acute physiological responses to these transmitters within single adult clock neuron soma. We extended these live imaging methods to s-LN(v)s, critical neuronal pacemakers whose physiological properties in the adult brain are largely unknown. Our s-LN(v) experiments revealed the predicted excitatory responses to bath-applied cholinergic agonists and the predicted inhibitory effects of GABA and established that the antagonism of ACh and GABA extends to their effects on cAMP signaling. These data support recently published but physiologically untested models of s-LN(v) modulation and lead to the prediction that cholinergic and GABAergic inputs to s-LN(v)s will have opposing effects on the phase and/or period of the molecular clock within these critical pacemaker neurons.
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Takemoto, Yumi
2014-12-01
The thiol amino acid L-cysteine increases arterial blood pressure (ABP) when injected into the cerebrospinal fluid space in conscious rats, indicating a pressor response to centrally acting L-cysteine. A prior synaptic membrane binding assay suggests that L-cysteine has a strong affinity for the L-2-amino-4-phosphonobutyric acid (L-AP4) binding site. The central action of L-cysteine may be vial-AP4 sensitive receptors. The present study investigated cardiovascular responses to L-cysteine and L-ap4 microinjected into the autonomic area of the caudal ventrolateral medulla (CVLM) where inhibitory neurons regulate ABP via pre-sympathetic vasomotor neurons. Both the injection of L-cysteine and L-AP4 in the CVLM sites identified with L-glutamate produced the same depressor and bradycardic responses in urethane-anesthetized rats. Neither a prior antagonist microinjection of MK801 for the N-methyl-D-aspartate (NMDA) receptor nor CNQX for the non-NMDA receptor attenuated the responses to L-cysteine, but the combination of the two receptor blocking with an additional prior injection abolished the response. In contrast, either receptor blockade alone abolished the response to L-AP4, indicating distinct mechanisms between responses to L-cysteine and L-AP4 in the CVLM. The results indicate that the CVLM is a central active site for L-cysteine's cardiovascular response. Central L-cysteine's action could be independent of the L-AP4 sensitive receptors. Cardiovascular regulation may involve endogenous L-cysteine in the CVLM. Further multidisciplinary examinations are required to elaborate on L-cysteine's functional roles in the CVLM. Copyright © 2014 Elsevier B.V. All rights reserved.
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Arico, Carolyn; Bagley, Elena E; Carrive, Pascal; Assareh, Neda; McNally, Gavan P
2017-10-01
The midbrain periaqueductal gray (PAG) has been implicated in the generation and transmission of a prediction error signal that instructs amygdala-based fear and extinction learning. However, the PAG also plays a key role in the expression of conditioned fear responses. The evidence for a role of the PAG in fear learning and extinction learning has been obtained almost exclusively using PAG-dependent fear responses. It is less clear whether the PAG regulates fear learning when other measures of learned fear are used. Here we combined a chemogenetic approach, permitting excitation or inhibition of neurons in the ventrolateral PAG (VLPAG), with conditioned suppression as the measure of learned fear to assess the role of VLPAG in the acquisition and extinction of fear learning. We show that chemogenetic excitation of VLPAG (with some encroachment on lateral PAG [LPAG]) impairs acquisition of fear and, conversely, chemogenetic inhibition impairs extinction of fear. These effects on fear and extinction learning were specific to the combination of DREADD expression and injection of CNO because they were observed relative to both eYFP controls injected with CNO as well as DREADD expressing controls injected with vehicle. Taken together, these results show that activity of L/VLPAG neurons regulates both the acquisition and extinction of Pavlovian fear learning. Copyright © 2017 Elsevier Inc. All rights reserved.
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Takemoto, Yumi
2014-04-01
The endogenous sulfur-containing amino acid L-cysteine injected into the cerebrospinal fluid space of the cisterna magna increases arterial blood pressure (ABP) and heart rate (HR) in the freely moving rat. The present study examined (1) cardiovascular responses to L-cysteine microinjected into the rostral ventrolateral medulla (RVLM), where a group of neurons regulate activities of cardiovascular sympathetic neurons and (2) involvement of ionotropic excitatory amino acid (iEAA) receptors in response. In the RVLM of urethane-anesthetized rats accessed ventrally and identified with pressor responses to L-glutamate (10 mM, 34 nl), microinjections of L-cysteine increased ABP and HR dose dependently (3-100 mM, 34 nl). The cardiovascular responses to L-cysteine (30 mM) were not attenuated by a prior injection of either antagonist alone, MK801 (20 mM, 68 nl) for the NMDA type of iEAA receptors, or CNQX (2 mM) for the non-NMDA type. However, inhibition of both NMDA and non-NMDA receptors with additional prior injection of either antagonist completely blocked those responses to L-cysteine. The results indicate that L-cysteine has functional cardiovascular action in the RVLM of the anesthetized rat, and the responses to L-cysteine involve both NMDA and non-NMDA receptors albeit in a mutually exclusive parallel fashion. The findings may suggest endogenous roles of L-cysteine indirectly via iEAA receptors in the neuronal network of the RVLM for cardiovascular regulation in physiological and pathological situations.
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Souza, Luiz Eduardo de
2015-01-01
Programa de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa de Pós Graduação, Universidade Federal de Ouro Preto. O exercício físico tem importante ação no sistema nervoso e órgãos reguladores da pressão arterial. Objetivos: Verificar o efeito do exercício físico sobre a expressão das óxido nítrico sintases (NOSs) no bulbo ventrolateral rostral (RVLM) e estado redox no encéfalo, coração, rins e aorta de ratos com hipertensão re...
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Han, Fei
2014-01-01
A computational strategy to predict the elastic properties of carbon nanotube-reinforced polymer composites is proposed in this two-part paper. In Part I, the micro-structural characteristics of these nano-composites are discerned. These characteristics include networks/agglomerations of carbon nanotubes and thick polymer interphase regions between the nanotubes and the surrounding matrix. An algorithm is presented to construct three-dimensional geometric models with large amounts of randomly dispersed and aggregated nanotubes. The effects of the distribution of the nanotubes and the thickness of the interphase regions on the concentration of the interphase regions are demonstrated with numerical results. © 2013 Elsevier B.V. All rights reserved.
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Guo, Zhi-Ling; Longhurst, John C.
2010-01-01
Electroacupuncture (EA) at the Jianshi-Neiguan acupoints (P5-P6, overlying the median nerve) attenuates sympathoexcitatory responses through activation of the arcuate nucleus (ARC) and ventrolateral periaqueductal gray (vlPAG). Activation of the ARC or vlPAG respectively leads to neuronal excitation of the both nuclei during EA. However, direct projections between these two nuclei that could participate in central neural processing during EA have not been identified. The vesicular glutamate transporter 3 (VGLUT3) marks glutamatergic neurons. Thus, the present study evaluated direct neuronal projections between the ARC and vlPAG during EA, focusing on neurons containing VGLUT3. Seven to ten days after unilateral microinjection of a rodamine-conjugated microsphere retrograde tracer (100 nl) into the vlPAG or ARC, rats were subjected to EA or served as a sham-operated control. Low frequency (2 Hz) EA was performed bilaterally for 30 min at the P5-P6 acupoints. Perikarya containing the microsphere tracer were found in the ARC and vlPAG of both groups. Compared to controls (needle placement without electrical stimulation), c-Fos immunoreactivity and neurons double-labeled with c-Fos, an immediate early gene and the tracer were increased significantly in the ARC and vlPAG of EA-treated rats (both P<0.01). Moreover, some neurons were triple-labeled with c-Fos, the retrograde tracer and VGLUT3 in the two nuclei following EA stimulation (P<0.01, both nuclei). These results suggest that direct reciprocal projections between the ARC and vlPAG are available to participate in prolonged modulation by EA of sympathetic activity and that VGLUT3-containing neurons are an important neuronal phenotype involved in this process. PMID:20836994
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DEFF Research Database (Denmark)
Schrøder, H D
1981-01-01
in the length of the nucleus was observed. Based on the cytoarchitecture the nucleus could be divided in three parts, a cranial, a dorsomedial and a ventrolateral. All parts of the nucleus consisted of chromatin-rich medium-sized neurons, and apparent direct appositions between different cells bodies as well...
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Robert J. Stimson
2012-01-01
The Global Financial Crisis (GFC) was a profound exogenous shock which has had profound impacts the performance of national economies and the regions within them. The differential outcomes are vast. In many parts of the world there is evidence of what is being referred to as the ‘two-speed’ economy - or even a ‘multi-speed’ - economy. This has implications for regional economic development theory in which, over the last two to three decades, there has been an increasing emphasis on endogenous...
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Murty, A. S. N.; Sarkar, Dipankar; Sen, Mrinal K.; Sridher, V.; Prasad, A. S. S. S. R. S.
2014-10-01
Deccan Traps spread over large parts of south, west and central India, possibly hiding underneath sediments with hydrocarbon potential. Here, we present the results of seismic refraction and wide-angle reflection experiments along three profiles, and analyze them together the results from all other refraction profiles executed earlier in the western part of Narmada-Tapti region of the Deccan Volcanic Province (DVP). We employ travel time modelling to derive the granitic basement configuration, including the overlying Trap and sub-trappean sediment thickness, if any. Travel time skips and amplitude decay in the first arrival refraction data are indicative of the presence of low velocity sediments (Mesozoic), which are the low velocity zones (LVZ) underneath the Traps. Reflection data from the top of LVZ and basement along with the basement refraction data have been used to derive the Mesozoic sediment thickness. In the middle and eastern parts of the study region between Narmada and Tapti, the Mesozoic sediment thickness varies between 0.5 and 2.0 km and reaches more than 2.5 km south of Sendhwa between Narmada and Tapti Rivers. Thick Mesozoic sediments in the eastern parts are also accompanied by thick Traps. The Mesozoic sediments along the present three profiles may not be much prospective in terms of its thickness, except inside the Cambay basin, where the subtrappean sediment thickness is about 1000-1500 m. In the eastern part of the study area, the deepest section (>4 km) has thick (∼2 km) Mesozoic sediments, but with almost equally thick Deccan Trap cover. Results of the present study provide important inputs for future planning for hydrocarbon exploration in this region.
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International Nuclear Information System (INIS)
Silva Junior, Renato Oliveira da; Dall'Agnol, Roberto; Oliveira, Elson Paiva de
1996-01-01
The paper synthesizes the geological, petrographical, geochemical and geochronological data from the Maria River region dikes, situated at the southeastern part of the Para State, Brazil. It identifies five groups of dikes and determines the age of these dikes, through the Potassium-Argon (K-Ar) methodology
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Satpute, Ajay B; Badre, David; Ochsner, Kevin N
2014-05-01
Research in social neuroscience has uncovered a social knowledge network that is particularly attuned to making social judgments. However, the processes that are being performed by both regions within this network and those outside of this network that are nevertheless engaged in the service of making a social judgment remain unclear. To help address this, we drew upon research in semantic memory, which suggests that making a semantic judgment engages 2 distinct control processes: A controlled retrieval process, which aids in bringing goal-relevant information to mind from long-term stores, and a selection process, which aids in selecting the information that is goal-relevant from the information retrieved. In a neuroimaging study, we investigated whether controlled retrieval and selection for social information engage distinct portions of both the social knowledge network and regions outside this network. Controlled retrieval for social information engaged an anterior ventrolateral portion of the prefrontal cortex, whereas selection engaged both the dorsomedial prefrontal cortex and temporoparietal junction within the social knowledge network. These results suggest that the social knowledge network may be more involved with the selection of social information than the controlled retrieval of it and incorporates lateral prefrontal regions in accessing memory for making social judgments.
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Wu, Kay L H; Chao, Yung-Mei; Tsay, Shiow-Jen; Chen, Chen Hsiu; Chan, Samuel H H; Dovinova, Ima; Chan, Julie Y H
2014-10-01
Metabolic syndrome (MetS), which is rapidly becoming prevalent worldwide, is long known to be associated with hypertension and recently with oxidative stress. Of note is that oxidative stress in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons reside, contributes to sympathoexcitation and hypertension. This study sought to identify the source of tissue oxidative stress in RVLM and their roles in neural mechanism of hypertension associated with MetS. Adult normotensive rats subjected to a high-fructose diet for 8 weeks developed metabolic traits of MetS, alongside increases in sympathetic vasomotor activity and blood pressure. In RVLM of these MetS rats, the tissue level of reactive oxygen species was increased, nitric oxide (NO) was decreased, and mitochondrial electron transport capacity was reduced. Whereas the protein expression of neuronal NO synthase (nNOS) or protein inhibitor of nNOS was increased, the ratio of nNOS dimer/monomer was significantly decreased. Oral intake of pioglitazone or intracisternal infusion of tempol or coenzyme Q10 significantly abrogated all those molecular events in high-fructose diet-fed rats and ameliorated sympathoexcitation and hypertension. Gene silencing of protein inhibitor of nNOS mRNA in RVLM using lentivirus carrying small hairpin RNA inhibited protein inhibitor of nNOS expression, increased the ratio of nNOS dimer/monomer, restored NO content, and alleviated oxidative stress in RVLM of high-fructose diet-fed rats, alongside significantly reduced sympathoexcitation and hypertension. These results suggest that redox-sensitive and protein inhibitor of nNOS-mediated nNOS uncoupling is engaged in a vicious cycle that sustains the production of reactive oxygen species in RVLM, resulting in sympathoexcitation and hypertension associated with MetS. © 2014 American Heart Association, Inc.
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Directory of Open Access Journals (Sweden)
Lacerda J.E.C.
2003-01-01
Full Text Available The rostral ventrolateral medulla (RVLM contains neurons involved in tonic and reflex control of arterial pressure. We describe the effects of gamma-aminobutyric acid (GABA and anesthetics injected into the RVLM of conscious and urethane (1.2 g/kg, iv anesthetized Wistar rats (300-350 g. In conscious rats, bilateral microinjection of GABA (50 nmol/200 nl induced a small but significant decrease in blood pressure (from 130 ± 3.6 to 110 ± 5.6 mmHg, N = 7. A similar response was observed with sodium pentobarbital microinjection (24 nmol/200 nl. However, in the same animals, the fall in blood pressure induced by GABA (from 121 ± 8.9 to 76 ± 8.8 mmHg, N = 7 or pentobarbital (from 118 ± 4.5 to 57 ± 11.3 mmHg, N = 6 was significantly increased after urethane anesthesia. In contrast, there was no difference between conscious (from 117 ± 4.1 to 92 ± 5.9 mmHg, N = 7 and anesthetized rats (from 123 ± 6.9 to 87 ± 8.7 mmHg, N = 7 when lidocaine (34 nmol/200 nl was microinjected into the RVLM. The heart rate variations were not consistent and only eventually reached significance in conscious or anesthetized rats. The right position of pipettes was confirmed by histology and glutamate microinjection into the RVLM. These findings suggest that in conscious animals the RVLM, in association with the other sympathetic premotor neurons, is responsible for the maintenance of sympathetic vasomotor tone during bilateral RVLM inhibition. Activity of one or more of these premotor neurons outside the RVLM can compensate for the effects of RVLM inhibition. In addition, the effects of lidocaine suggest that fibers passing through the RVLM are involved in the maintenance of blood pressure in conscious animals during RVLM inhibition.
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Jansen, A S; Farkas, E; Mac Sams, J; Loewy, A D
1998-02-16
Chemical stimulation of the lateral or ventrolateral columns of the midbrain periaqueductal gray matter (PAG) in conscious animals produces opposite responses (viz., defensive behavior and pressor responses from the lateral column vs. quiescence and depressor responses from the ventrolateral column), raising the possibility that the two columns are interconnected. To test this hypothesis, two types of anatomical experiments were performed in rats. First, the anterograde axonal marker Phaseolus vulgaris leuco-agglutinin (PHA-L) was injected into individual PAG columns or adjoining regions which included the Edinger-Westphal, dorsal raphe, and precommissural nuclei. The results shows that each column projects bilaterally to all of the other PAG columns, and also provides local connections within its own column. Furthermore, the Edinger-Westphal and precommissural nuclei project to all four PAG columns, while the dorsal raphe nucleus projects only to the ventrolateral and lateral columns. In a second experiment, we found that cardiovascular-related PAG projection neurons of both the lateral and ventrolateral columns receive an input from the reciprocal PAG column. This was demonstrated by a double tracer neuroanatomical study in which PHA-L was first iontophoretically ejected into either the lateral or ventrolateral PAG columns and then, several days later the retrograde transneuronal viral tracer, pseudorabies virus, was injected into the stellate sympathetic ganglion. Intra-PAG circuits were visualized by a dual immunohistochemical procedure. These results suggest that during the fight-or-flight response when the 'fight' program is activated, inhibition of the 'flight' PAG network may occur and the converse situation may occur during the flight response. Copyright 1997 Elsevier Science B.V.
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Belik, Anton; Devyatova, Tatiana; Bozhko, Svetlana; Gorbunova, Yulia
2016-04-01
The infield varietu of available forms in the forest-steppe of western part Central Chernozemic region The Central Chernozemic region of Russia has been a region with a strong agricultural industry and determines the food security of the state by most part. The soil cover of the region is represented mainly by chernozems and is favorable for the cultivation of major crops and produce high crop yields. However, the high development of agriculture in the territory of Central Chernozemic region are led to the development of agrogenic degradation processes which impacts on the growth of the soil cover complexity and contrast, and as a consequence a significant infield variety of soil fertility and yields of major crops. In this regard, very promising direction in CChR is the development and practical application technologies of precision agriculture, which implies the spatial variety of soil fertility analysis within specific fields and work areas, especially the content of available forms of nutrients. The aim of our research was a study of the agro-ecological characteristics of the spatial variety of the content by available forms to plants of major nutrients in representative areas of sloping agricultural landscapes with forest-steppe chernozems in the western part of Central Chernozemic region of Russia. The research of infield variety by content of available forms of major nutrients are carried in the fields of Russian Research Institute of Agriculture and Protect the Soil from Erosion experimental and industrial farm in Medvensky district of Kursk region. The area characterized by a complex organization of relief. The soil cover is represented by full-profile typical (conventional and carbonate), leached chernozems. The growth of contrast of the soil cover are largely determined by the appearance of eroded soils of these analogues, as well as zoogenic dug and accumulative soils All of the studied areas with the forest-steppe chernozems were characterized by
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Mapping of radioactivity in topsoil and reindeer lichens in parts of the Barents Region
International Nuclear Information System (INIS)
Halleraker, J.H.; Reimann, C.; Aeyraes, M.; Chekushin, V.A.; Rissanen, K.; Strand, T.
1995-01-01
The Geological Surveys of Finland (GTK), Norway (NGU) and Russia (CKE) are carrying out a major collaborative regional geochemical mapping project in an area north of the Arctic Circle in these three countries. The aims are to establish regional geochemical maps of the distribution of heavy metals and radionuclides within the study area, to build up a soil sample bank for use in future studies and to assess the environmental impact of the heavy metal industry and nuclear activity in this ecologically vulnerable area. A detailed study of eight small catchments situated at different distances from major industrial centres within the project area was carried out as part of the main project during 1994. The objective of this study was to better understand the processes occurring within catchment areas and to identify inter-relationships between different media. A high variation of the natural occurrence of Th and U due to differing bedrock lithologies was observed in the catchment study. Surface concentrations of 134 Cs and 137 Cs were generally low, but highly variable on the small scale. Regional maps will be ready in 1996 covering 18,000 km 2 . 4 refs., 3 figs
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Sun, Jia-Cen; Liu, Bing; Zhang, Ru-Wen; Jiao, Pei-Lei; Tan, Xing; Wang, Yang-Kai; Wang, Wei-Zhong
2018-01-01
Background: Hypertension is characterized by sympathetic overactivity, which is associated with an enhancement in angiotensin receptor type I (AT1R) in the rostral ventrolateral medulla (RVLM). β-arrestin1, a canonical scaffold protein, has been suggested to show a negative effect on G protein-coupled receptors via its internalization and desensitization and/or the biased signaling pathway. The major objectives of the present study were to observe the effect of β-arrestin1 overexpression in the RVLM on cardiovascular regulation in spontaneously hypertensive rats (SHR), and further determine the effect of β-arrestin1 on AT1R expression in the RVLM. Methods: The animal model of β-arrestin1 overexpression was induced by bilateral injection of adeno-associated virus containing Arrb1 gene (AAV-Arrb1) into the RVLM of WKY and SHR. Results: β-arrestin1 was expressed on the pre-sympathetic neurons in the RVLM, and its expression in the RVLM was significantly ( P Overexpression of β-arrestin1 in SHR significantly decreased baseline levels of blood pressure and renal sympathetic nerve activity, and attenuated cardiovascular effects induced by RVLM injection of angiotensin II (100 pmol). Furthermore, β-arrestin1 overexpression in the RVLM significantly reduced the expression of AT1R by 65% and NF-κB p65 phosphorylation by 66% in SHR. It was confirmed that β-arrestin1 overexpression in the RVLM led to an enhancement of interaction between β-arrestin1 and IκB-α. Conclusion: Overexpression of β-arrestin1 in the RVLM reduces BP and sympathetic outflow in hypertension, which may be associated with NFκB-mediated AT1R downregulation.
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Mendes-Gomes, Joyce; Amaral, Vanessa Cristiane Santana; Nunes-de-Souza, Ricardo Luiz
2011-06-01
The exposure of rodents to an open elevated plus-maze (oEPM: four open arms raised from the floor) elicits naloxone-insensitive antinociception. Midazolam infusion into the dorsal portion of the periaqueductal gray (dPAG), a structure of the descending inhibitory system of pain, failed to alter oEPM-induced antinociception. Chemical lesion of dorsomedial and dorsolateral PAG attenuated defensive behavior in the standard EPM (sEPM), an animal model of anxiety, but failed to change oEPM-induced antinociception. The present study investigated the effects of bilateral lesion, with the injection of NMDA (N-methyl-D-aspartic acid), of the ventrolateral column of PAG (vlPAG) (i) on nociceptive response induced by 2.5% formalin injected into the right hind paw (nociception test) in mice exposed to the enclosed EPM (eEPM: four enclosed arms - a non-aversive situation) or to the oEPM and (ii) on anxiety indices in mice exposed to the sEPM without prior formalin injection. Results showed that oEPM-induced antinociception was not altered by lesion of vlPAG. Nevertheless, the lesion reduced the nociceptive response in mice exposed to the eEPM and increased general locomotor activity during the eEPM and oEPM exposure. Furthermore, vlPAG lesion did not alter anxiety-like indices in mice exposed to the sEPM. The results suggest that vlPAG does not play a role in oEPM-induced antinociception or in defensive reactions assessed in the sEPM. Moreover, vlPAG inactivation induces pain inhibition in mice not exposed to an aversive situation and seems to increase general activity. Copyright © 2011 Elsevier B.V. All rights reserved.
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Basso Moro, Sara; Carrieri, Marika; Avola, Danilo; Brigadoi, Sabrina; Lancia, Stefania; Petracca, Andrea; Spezialetti, Matteo; Ferrari, Marco; Placidi, Giuseppe; Quaresima, Valentina
2016-06-01
Objective. In the last few years, the interest in applying virtual reality systems for neurorehabilitation is increasing. Their compatibility with neuroimaging techniques, such as functional near-infrared spectroscopy (fNIRS), allows for the investigation of brain reorganization with multimodal stimulation and real-time control of the changes occurring in brain activity. The present study was aimed at testing a novel semi-immersive visuo-motor task (VMT), which has the features of being adopted in the field of neurorehabilitation of the upper limb motor function. Approach. A virtual environment was simulated through a three-dimensional hand-sensing device (the LEAP Motion Controller), and the concomitant VMT-related prefrontal cortex (PFC) response was monitored non-invasively by fNIRS. Upon the VMT, performed at three different levels of difficulty, it was hypothesized that the PFC would be activated with an expected greater level of activation in the ventrolateral PFC (VLPFC), given its involvement in the motor action planning and in the allocation of the attentional resources to generate goals from current contexts. Twenty-one subjects were asked to move their right hand/forearm with the purpose of guiding a virtual sphere over a virtual path. A twenty-channel fNIRS system was employed for measuring changes in PFC oxygenated-deoxygenated hemoglobin (O2Hb/HHb, respectively). Main results. A VLPFC O2Hb increase and a concomitant HHb decrease were observed during the VMT performance, without any difference in relation to the task difficulty. Significance. The present study has revealed a particular involvement of the VLPFC in the execution of the novel proposed semi-immersive VMT adoptable in the neurorehabilitation field.
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Tamaddonfard, Esmaeal; Erfanparast, Amir; Abbas Farshid, Amir; Delkhosh-Kasmaie, Fatmeh
2017-11-15
Acetylcholine, as a major neurotransmitter, mediates many brain functions such as pain. This study was aimed to investigate the effects of microinjection of muscarinic and nicotinic acetylcholine receptor antagonists and agonists into the ventrolateral orbital cortex (VLOC) on capsaicin-induced orofacial nociception and subsequent hyperalgesia. The right side of VLOC was surgically implanted with a guide cannula in anaesthetized rats. Orofacial pain-related behaviors were induced by subcutaneous injection of a capsaicin solution (1.5µg/20µl) into the left vibrissa pad. The time spent face rubbing with ipsilateral forepaw and general behavior were recorded for 10min, and then mechanical hyperalgesia was determined using von Frey filaments at 15, 30, 45 and 60min post-capsaicin injection. Alone intra-VLOC microinjection of atropine (a muscarinic acetylcholine receptor antagonist) and mecamylamine (a nicotinic acetylcholine receptor antagonist) at a similar dose of 200ng/site did not alter nocifensive behavior and hyperalgesia. Microinjection of oxotremorine (a muscarinic acetylcholine receptor agonist) at doses of 50 and 100ng/site and epibatidine (a nicotinic acetylcholine receptor agonist) at doses of 12.5, 25, 50 and 100ng/site into the VLOC suppressed pain-related behaviors. Prior microinjections of 200ng/site atropine and mecamylamine (200ng/site) prevented oxotremorine (100ng/site)-, and epibatidine (100ng/site)-induced antinociception, respectively. None of the above-mentioned chemicals changed general behavior. These results showed that the VLOC muscarinic and nicotinic acetylcholine receptors might be involved in modulation of orofacial nociception and hypersensitivity. Copyright © 2017 Elsevier B.V. All rights reserved.
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The interaction of process and domain in prefrontal cortex during inductive reasoning.
Babcock, Laura; Vallesi, Antonino
2015-01-01
Inductive reasoning is an everyday process that allows us to make sense of the world by creating rules from a series of instances. Consistent with accounts of process-based fractionations of the prefrontal cortex (PFC) along the left-right axis, inductive reasoning has been reliably localized to left PFC. However, these results may be confounded by the task domain, which is typically verbal. Indeed, some studies show that right PFC activation is seen with spatial tasks. This study used fMRI to examine the effects of process and domain on the brain regions recruited during a novel pattern discovery task. Twenty healthy young adult participants were asked to discover the rule underlying the presentation of a series of letters in varied spatial locations. The rules were either verbal (pertaining to a single semantic category) or spatial (geometric figures). Bilateral ventrolateral PFC activations were seen for the spatial domain, while the verbal domain showed only left ventrolateral PFC. A conjunction analysis revealed that the two domains recruited a common region of left ventrolateral PFC. The data support a central role of left PFC in inductive reasoning. Importantly, they also suggest that both process and domain shape the localization of reasoning in the brain. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
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Church Vestries as Part of Church Administration in North Tobol Region During 1810-1860
Directory of Open Access Journals (Sweden)
Tsys’ Olga
2017-06-01
Full Text Available The paper examines main characteristics, structure and functions of church vestries in North Tobol region during the period of 1810–1860. It is concluded that the church vestry as a governing body of the Russian Orthodox Church during the Synodal period acted as an information mediator between the diocese and parish. As a rule, the church vestry exercised the authority over a particular district or part of it. Responsibilities of vestries were mainly limited to gathering and interpreting various pieces of information, overseeing the accounting and documentation of the parish clergy, fining the clergy and laymen for minor misconduct, and distributing the consistory’s decrees. The paper also demonstrates that vestries were collegial units, where decrees of the diocese, as well as reports and presentations of its members were discussed. It should be noted that boundaries of the district under the vestry’s jurisdiction were vague and not clearly marked. The common drawback of the vestries, as part of church administration, was the ambiguity in definition and description of roles and responsibilities. It was discovered that the remoteness of church administration from the majority of its parishes was specific to North Tobol region. It is concluded that church vestries were set up as administrative and organisational centres, and played a significant role in the administration of the Russian Orthodox Church. However, in the course of time the vestries started to lose their original role, becoming a redundant mediator in diocese and parish relations, which, in turn, led to the full abandonment of church vestries.
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Anderson, John R; Bothell, Daniel; Fincham, Jon M; Anderson, Abraham R; Poole, Ben; Qin, Yulin
2011-12-01
Part- and whole-task conditions were created by manipulating the presence of certain components of the Space Fortress video game. A cognitive model was created for two-part games that could be combined into a model that performed the whole game. The model generated predictions both for behavioral patterns and activation patterns in various brain regions. The activation predictions concerned both tonic activation that was constant in these regions during performance of the game and phasic activation that occurred when there was resource competition. The model's predictions were confirmed about how tonic and phasic activation in different regions would vary with condition. These results support the Decomposition Hypothesis that the execution of a complex task can be decomposed into a set of information-processing components and that these components combine unchanged in different task conditions. In addition, individual differences in learning gains were predicted by individual differences in phasic activation in those regions that displayed highest tonic activity. This individual difference pattern suggests that the rate of learning of a complex skill is determined by capacity limits.
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Thalamic control of human attention driven by memory and learning.
de Bourbon-Teles, José; Bentley, Paul; Koshino, Saori; Shah, Kushal; Dutta, Agneish; Malhotra, Paresh; Egner, Tobias; Husain, Masud; Soto, David
2014-05-05
The role of the thalamus in high-level cognition-attention, working memory (WM), rule-based learning, and decision making-remains poorly understood, especially in comparison to that of cortical frontoparietal networks [1-3]. Studies of visual thalamus have revealed important roles for pulvinar and lateral geniculate nucleus in visuospatial perception and attention [4-10] and for mediodorsal thalamus in oculomotor control [11]. Ventrolateral thalamus contains subdivisions devoted to action control as part of a circuit involving the basal ganglia [12, 13] and motor, premotor, and prefrontal cortices [14], whereas anterior thalamus forms a memory network in connection with the hippocampus [15]. This connectivity profile suggests that ventrolateral and anterior thalamus may represent a nexus between mnemonic and control functions, such as action or attentional selection. Here, we characterize the role of thalamus in the interplay between memory and visual attention. We show that ventrolateral lesions impair the influence of WM representations on attentional deployment. A subsequent fMRI study in healthy volunteers demonstrates involvement of ventrolateral and, notably, anterior thalamus in biasing attention through WM contents. To further characterize the memory types used by the thalamus to bias attention, we performed a second fMRI study that involved learning of stimulus-stimulus associations and their retrieval from long-term memory to optimize attention in search. Responses in ventrolateral and anterior thalamic nuclei tracked learning of the predictiveness of these abstract associations and their use in directing attention. These findings demonstrate a key role for human thalamus in higher-level cognition, notably, in mnemonic biasing of attention. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
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Bobeck, Erin N.; Haseman, Rachel A.; Hong, Dana; Ingram, Susan L.; Morgan, Michael M.
2012-01-01
Systemic administration of morphine typically produces greater tolerance than higher efficacy mu-opioid receptor (MOPr) agonists, such as fentanyl. The objective of the present study was to test this relationship by measuring antinociceptive efficacy and tolerance to morphine and fentanyl microinjected into the ventrolateral periaqueductal gray (vlPAG). MOPr agonist efficacy was evaluated by microinjecting the irreversible opioid receptor antagonist β-funaltrexamine hydrochloride (β-FNA) into the vlPAG prior to a dose-response analysis of morphine and fentanyl antinociception. In contrast to systemic administration of morphine and fentanyl, microinjection of these drugs into the vlPAG had similar efficacy as measured by similar reductions in maximal antinociception following β-FNA administration. Analysis of tolerance revealed a rightward shift in the dose-response curve to a single pretreatment with morphine, but not fentanyl. Moreover, the magnitude of tolerance to morphine was comparable following one, four, or eight pretreatments. Tolerance to fentanyl also was evident following four or eight microinjections. These data are surprising in that antinociceptive efficacy appears to vary depending on the site of administration. Moreover, the similar efficacy following microinjection of morphine and fentanyl into the vlPAG was associated with comparable tolerance, with the one exception of no tolerance to acute administration of fentanyl. Perspective These data reveal that antinociceptive tolerance following vlPAG administration of opioids develops rapidly, is evident with both morphine and fentanyl, and the magnitude is relatively consistent regardless of the number of pretreatments. PMID:22766006
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Directory of Open Access Journals (Sweden)
Jia-Cen Sun
2018-03-01
Full Text Available Background: Hypertension is characterized by sympathetic overactivity, which is associated with an enhancement in angiotensin receptor type I (AT1R in the rostral ventrolateral medulla (RVLM. β-arrestin1, a canonical scaffold protein, has been suggested to show a negative effect on G protein-coupled receptors via its internalization and desensitization and/or the biased signaling pathway. The major objectives of the present study were to observe the effect of β-arrestin1 overexpression in the RVLM on cardiovascular regulation in spontaneously hypertensive rats (SHR, and further determine the effect of β-arrestin1 on AT1R expression in the RVLM.Methods: The animal model of β-arrestin1 overexpression was induced by bilateral injection of adeno-associated virus containing Arrb1 gene (AAV-Arrb1 into the RVLM of WKY and SHR.Results: β-arrestin1 was expressed on the pre-sympathetic neurons in the RVLM, and its expression in the RVLM was significantly (P < 0.05 downregulated by an average of 64% in SHR than WKY. Overexpression of β-arrestin1 in SHR significantly decreased baseline levels of blood pressure and renal sympathetic nerve activity, and attenuated cardiovascular effects induced by RVLM injection of angiotensin II (100 pmol. Furthermore, β-arrestin1 overexpression in the RVLM significantly reduced the expression of AT1R by 65% and NF-κB p65 phosphorylation by 66% in SHR. It was confirmed that β-arrestin1 overexpression in the RVLM led to an enhancement of interaction between β-arrestin1 and IκB-α.Conclusion: Overexpression of β-arrestin1 in the RVLM reduces BP and sympathetic outflow in hypertension, which may be associated with NFκB-mediated AT1R downregulation.
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The role of the left ventrolateral prefrontal cortex in online sentence processing
Directory of Open Access Journals (Sweden)
Nazbanou Nozari
2014-04-01
Full Text Available Introduction: Patients with damage to the left ventrolateral prefrontal cortex (VLPFC are often not impaired in understanding simple sentences. It is, however, possible that the damage may cause subclinical effects. If VLPFC has a role in biasing competition towards what is relevant to the task, we would expect patients with VLPFC damage to be slower in using the relevant information and discarding the irrelevant information when they process sentences online. Methods: Nine patients, five with lesions limited to VLPFC, and four with lesions sparing VLPFC participated. The groups were matched in age, education, WAB-AQ and total lesion volume. Two experiments explored processing of online cues during sentence comprehension by tracking eye fixations in a Visual World paradigm with four pictures. Participants only listened to the sentences and looked at the pictures. Experiment 1 investigated how quickly cues can be used for target identification using a simple “She will [verb] the [target].” sentence structure. The verbs in the restrictive condition were compatible with only one of the four pictures (e.g., “eat”; target “apple” + three inedible competitors. The verbs in the control conditions were matched to the restrictive verbs in length and frequency, but did not point to a unique target (e.g., “see”. If VLPFC is critical for quickly biasing competition towards the relevant target, the VLPFC patients should to be slower than the non-VLPFC patients in fixating the noun when the verb is restrictive. Experiment 2 probed how effectively irrelevant cues are suppressed. A similar Visual World paradigm was used, but all verbs were restrictive, and one of the distractors was also compatible with the verb (e.g., “banana”. The sentences contained an adjective that ruled out one of verb-compatible pictures (e.g., “red”. The critical manipulation involved a third picture (the adjective competitor which was compatible with the
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Directory of Open Access Journals (Sweden)
Izabella Silva De Jesus Pinto
2016-06-01
Full Text Available IIntrathecal injection of bombesin (BBS promoted hypertensive and sympathoexcitatory effects in normotensive (NT rats. However, the involvement of rostral ventrolateral medulla (RVLM in these responses is still unclear. In the present study, we investigated: (1 the effects of BBS injected bilaterally into RVLM on cardiorespiratory and sympathetic activity in NT and spontaneously hypertensive rats (SHR; (2 the contribution of RVLM bombesin type 1 receptors (BB1 to the maintenance of hypertension in SHR. Urethane-anesthetized rats (1.2 g · kg−1, i.v. were instrumented to record mean arterial pressure (MAP, diaphragm (DIA motor and renal sympathetic nerve activity (RSNA. In NT rats and SHR, BBS (0.3 mM nanoinjected into RVLM increased MAP (33.9 ± 6.6 mmHg and 37.1 ± 4.5 mmHg, respectively; p < 0.05 and RSNA (97.8 ± 12.9 % and 84.5 ± 18.1 %, respectively; p < 0.05. In SHR, BBS also increased DIA burst amplitude (115.3 ± 22.7 %; p < 0.05. BB1 receptors antagonist (BIM-23127; 3 mM reduced MAP (-19.9 ± 4.4 mmHg; p < 0.05 and RSNA (-17.7 ± 3.8 %; p < 0.05 in SHR, but not in NT rats (-2.5 ± 2.8 mmHg; -2.7 ± 5.6 %, respectively. These results show that BBS can evoke sympathoexcitatory and pressor responses by activating RVLM BB1 receptors. This pathway might be involved in the maintenance of high levels of arterial blood pressure in SHR.
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Oshima, Naoki; Onimaru, Hiroshi; Matsubara, Hidehito; Uchida, Takahiro; Watanabe, Atsushi; Imakiire, Toshihiko; Nishida, Yasuhiro; Kumagai, Hiroo
2017-03-06
Although patients with diabetes mellitus (DM) often exhibit hypertension, the mechanisms responsible for this correlation are not well known. We hypothesized that the bulbospinal neurons in the rostral ventrolateral medulla (RVLM) are affected by the levels of glucose, insulin, or incretins (glucagon like peptide-1 [GLP-1] or glucose-dependent insulinotropic peptide [GIP]) in patients with DM. To investigate whether RVLM neurons are activated by glucose, insulin, GLP-1, or GIP, we examined changes in the membrane potentials of bulbospinal RVLM neurons using whole-cell patch-clamp technique during superfusion with various levels of glucose or these hormones in neonatal Wistar rats. A brainstem-spinal cord preparation was used for the experiments. A low level of glucose stimulated bulbospinal RVLM neurons. During insulin superfusion, almost all the RVLM neurons were depolarized, while during GLP-1 or GIP superfusion, almost all the RVLM neurons were hyperpolarized. Next, histological examinations were performed to examine transporters for glucose and receptors for insulin, GLP-1, and GIP on RVLM neurons. Low-level glucose-depolarized RVLM neurons exhibited the presence of glucose transporter 3 (GLUT3). Meanwhile, insulin-depolarized, GLP-1-hyperpolarized, and GIP-hyperpolarized RVLM neurons showed each of the respective specific receptor. These results indicate that a low level of glucose stimulates bulbospinal RVLM neurons via specific transporters on these neurons, inducing hypertension. Furthermore, an increase in insulin or a reduction in incretins may also activate the sympathetic nervous system and induce hypertension by activating RVLM neurons via their own receptors. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.
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Pontine control of ejaculation and female orgasm.
Huynh, Hieu K; Willemsen, Antoon T M; Lovick, Thelma A; Holstege, Gert
2013-12-01
The physiological component of ejaculation shows parallels with that of micturition, as both are essentially voiding activities. Both depend on supraspinal influences to orchestrate the characteristic pattern of activity in the pelvic organs. Unlike micturition, little is known about the supraspinal pathways involved in ejaculation and female orgasm. To identify brainstem regions activated during ejaculation and female orgasm and to compare them with those activated during micturition. Ejaculation in men and orgasm in women were induced by manual stimulation of the penis or clitoris by the participants' partners. Positron emission tomography (PET) with correction for head movements was used to capture the pattern of brain activation at the time of sexual climax. PET scans showing areas of activation during sexual climax. Ejaculation in men and orgasm in women resulted in activation in a localized region within the dorsolateral pontine tegmentum on the left side and in another region in the ventrolateral pontine tegmentum on the right side. The dorsolateral pontine area was also active in women who attempted but failed to have an orgasm and in women who imitated orgasm. The ventrolateral pontine area was only activated during ejaculation and physical orgasm in women. Activation of a localized region on the left side in the dorsolateral pontine tegmentum, which we termed the pelvic organ-stimulating center, occurs during ejaculation in men and physical orgasm in women. This same region has previously been shown to be activated during micturition, but on the right side. The pelvic organ-stimulating center, via projections to the sacral parasympathetic motoneurons, controls pelvic organs involved in voiding functions. In contrast, the ventrolateral pontine area, which we term the pelvic floor-stimulating center, produces the pelvic floor contractions during ejaculation in men and physical orgasm in women via direct projections to pelvic floor motoneurons. © 2013
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Sonography, CT and MR in soft part growths in the head and neck region
International Nuclear Information System (INIS)
Brinkmann, G.; Brix, F.; Beigel, A.
1990-01-01
14 patients with a space-occupying growth in the head and neck region were examined via sonography, CT and MR to explore and demonstrate by means of a prospective comparative study the possibilities offered by these three imaging methods. Stages are best diagnosed by means of sonography; the leading role of this method is undisputed. To clarify sonographically unclear findings and especially in pre-surgery planning, MR offers advantages over CT on account of the high soft-part contrast and multiplanar visualisation. However, it is impossible or very difficult to differentiate abscesses and lymphadenitides from malignant growths with these three methods solely on the basis of image-morphological criteria. (orig.) [de
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The Development of the Ventral Prefrontal Cortex and Social Flexibility
Nelson, Eric E.; Guyer, Amanda E.
2011-01-01
Over the last several years a number of studies in both humans and animals have suggested that the orbitofrontal and ventrolateral prefrontal cortices play an important role in generating flexible behavior. We suggest that input from these brain regions contribute to three functions involved in generating flexible behavior within social contexts: valuation, inhibition, and rule use. Recent studies have also demonstrated that the prefrontal cortex undergoes a prolonged course of maturation that extends well after puberty. Here, we review evidence that the prolonged development of these prefrontal regions parallels a slowly emerging ability for flexible social behavior. We also speculate on the possibility that sensitive periods for organizing social behavior may be embedded within this developmental time-fame. Finally, we discuss the role of prefrontal cortex in adolescent mood and anxiety disorders, particularly as orbitofrontal and ventrolateral prefrontal cortices are engaged in a social context. PMID:21804907
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Is human imitation based on a mirror-neuron system? Some behavioural evidence
Wohlschläger, A.; Bekkering, H.
2002-01-01
Recently, a population of neurones was discovered in the monkey's (Macaca nemestrina) ventrolateral part of the pre-motor cortex (area F5). It is specialised for recognising object-oriented actions, regardless of whether these actions are performed or observed by the monkey. The latter observation
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Is human imitation based on a mirror-neurone system? Some behavioural evidence
Wohlschlager, A; Bekkering, H; Wohlschläger, A
Recently, a population of neurones was discovered in the monkey's (Macaca nemestrina) ventrolateral part of the pre-motor cortex (area F5). It is specialised for recognising object-oriented actions, regardless of whether these actions are performed or observed by the monkey. The latter observation
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Directory of Open Access Journals (Sweden)
Claire Bacon
Full Text Available Slit-Robo signaling guides commissural axons away from the floor-plate of the spinal cord and into the longitudinal axis after crossing the midline. In this study we have evaluated the role of the Slit-Robo GTPase activating protein 3 (srGAP3 in commissural axon guidance using a knockout (KO mouse model. Co-immunoprecipitation experiments confirmed that srGAP3 interacts with the Slit receptors Robo1 and Robo2 and immunohistochemistry studies showed that srGAP3 co-localises with Robo1 in the ventral and lateral funiculus and with Robo2 in the lateral funiculus. Stalling axons have been reported in the floor-plate of Slit and Robo mutant spinal cords but our axon tracing experiments revealed no dorsal commissural axon stalling in the floor plate of the srGAP3 KO mouse. Interestingly we observed a significant thickening of the ventral funiculus and a thinning of the lateral funiculus in the srGAP3 KO spinal cord, which has also recently been reported in the Robo2 KO. However, axons in the enlarged ventral funiculus of the srGAP3 KO are Robo1 positive but do not express Robo2, indicating that the thickening of the ventral funiculus in the srGAP3 KO is not a Robo2 mediated effect. We suggest a role for srGAP3 in the lateral positioning of post crossing axons within the ventrolateral funiculus.
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Gnanachandrasamy, G.; Ramkumar, T.; Venkatramanan, S.; Chung, S. Y.; Vasudevan, S.
2016-06-01
We use electrical resistivity data arrayed in a 2715 km2 region with 30 locations to identify the saline water intrusion zone in part of Cauvery deltaic region, offshore Eastern India. From this dataset we are able to derive information on groundwater quality, thickness of aquifer zone, structural and stratigraphic conditions relevant to groundwater conditions, and permeability of aquifer systems. A total of 30 vertical electrode soundings (VES) were carried out by Schlumberger electrode arrangement to indicate complete lithology of this region using curve matching techniques. The electrical soundings exhibited that H and HK type curves were suitable for 16 shallow locations, and QH, KQ, K, KH, QQ, and HA curves were fit for other location. Low resistivity values suggested that saline water intrusion occurred in this region. According to final GIS map, most of the region was severely affected by seawater intrusion due to the use of over-exploitation of groundwater.The deteriorated groundwater resources in this coastal region should raise environmental and health concerns.
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Energy Technology Data Exchange (ETDEWEB)
Gong, W.; Wang, W.C.
2000-01-01
This is the second part of a study investigating the 1991 severe precipitation event over the Uangtze-Huai River valley (YHRV) in China using both observations and regional model simulations. While Part 1 reported on the Mei-yu front and its association with large-scale circulation, this study documents the biases associated with the treatment of the lateral boundary in the regional model. Two aspects of the biases were studied: the driving field, which provides large-scale boundary forcing, and the coupling scheme, which specified how the forcing is adopted by the model. The former bias is defined as model uncertainty because it is not related to the model itself, while the latter bias (as well as those biases attributed to other sources) is referred to as model error. These two aspects were examined by analyzing the regional model simulations of the 1991 summer severe precipitation event over YHRV using different driving fields (ECMWF-TOGA objective analysis, ECMWF reanalysis, and NCEP-NCAR reanalysis) and coupling scheme (distribution function of the nudging coefficient and width of the buffer zone). Spectral analysis was also used to study the frequency distribution of the bias.
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DEFF Research Database (Denmark)
Haszprunar, Gerhard; Friedrich, Stefan; Wanninger, Andreas
2002-01-01
symmetrically situated pairs lying dorsolaterally and ventrolaterally in the pretrochal part of the trochophore-like larva and they send axons into the cerebral commissure. They are lost at metamorphosis. The fine structure of these cells strongly resembles that of so-called "ampullary cells" known from various...
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50 CFR 216.37 - Marine mammal parts.
2010-10-01
...: (1) The person transferring the part receives no remuneration of any kind for the marine mammal part... specifically authorized by the Regional Director, consistent with the requirements of paragraphs (a)(1) and (a... Regional Director of the transfer, including a description of the part, the person to whom the part was...
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Institute of Scientific and Technical Information of China (English)
CHEN Hai; ZHUANG Ping; ZHANG Yu-qing; LI Jian-yu; LI Yong-jie
2009-01-01
Background It has been proposed that parkinsonian motor signs result from hyperactivity in the output nucleus of the basal ganglia, which suppress the motor thalamus and cortical areas. This study aimed to explore the neuronal activity in the globus pallidus internus (GPi) and the ventrolateral thalamic nuclear group (ventral oral posterior/ventral intermediate, Vop/Vim) in patients with Parkinson's disease (PD).Methods Twenty patients with PD who underwent neurosurgery were studied. Microelectrode recording was performed in the GPi (n=10) and the Vop/Vim (n=10) intraoperatively. Electromyography (EMG) contralateral to the surgery was simultaneously performed. Single unit analysis was carried out. The interspike intervals (ISI) and coefficient of variation (CV) of ISI were calculated. Histograms of ISI were constructed. A unified Parkinson's disease rating scale (UPDRS) was used to assess the clinical outcome of surgery.Results Three hundred and sixty-three neurons were obtained from 20 trajectories. Of 175 GPi neurons, there were 15.4% with tremor frequency, 69.2% with tonic firing, and 15.4% with irregular discharge. Of 188 thalamic neurons, there were 46.8% with tremor frequency, 22.9% with tonic firing, and 30.3% with irregular discharge. The numbers of three patterns of neuron in GPi and Vop/Vim were significantly different (P <0.001). ISI analysis revealed that mean firing rate of the three patterns of GPi neurons was (80.9±63.9) Hz (n=78), which was higher than similar neurons with 62.9 Hz in a normal primate. For the Vop/Vim group, ISI revealed that mean firing rate of the three patterns of neurons (n=95) was (23.2±17.1) Hz which was lower than similar neurons with 30 Hz in the motor thalamus of normal primates. UPDRS indicated that the clinical outcome of pallidotomy was (64.3±9.5)%, (83.4±19.1)% and (63.4±36.3)%, and clinical outcome of thalamotomy was (92.2±12.9)%, (68.0±25.2)% and (44.3±27.2)% for tremor, rigidity and bradykinesia, respectively
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Harinarayana, Tirumalachetty; Borra, Veeraiah; Basava, Sharana; Suryabali, Singh
In search of new areas for hydrocarbon exploration, integrated ground geophysical studies have been taken up in Central India with seismic, magnetotellurics, deep resistivity and gravity surveys. Since the region is covered with basalt and well known for its intensive tectonic activity, remote sensing method seems to have value addition to the subsurface information derived from geophysical, geological and tectonic studies. The Narmada and Tapti rift zone and Deccan basalt covered regions of Central India, stems from its complexity. A Resourcesat-1 (IRS- P6) LISS-III satellite images covering an area of approximately 250,000 sq. km corresponding to the region in and around Baroda(Vadodara), Indore, Nandurbar, Khandwa, Akot, Nasik, Aurangabad, Pune and Latur in Central India was digitally processed and interpreted to present a schematic map of the geology and elucidate the structural fabric of the region. From our study, the disposition of the intensive dyke system, various faults and other lineaments in the region are delineated. Ground truth studies have shown good correlation with lineaments/dykes indicated in remote sensing studies and have revealed distinct ENE-WSW trending lineaments, dykes which are more prominent near the Narmada and Tapti river course. Evolution of these features with Deccan volcanism is discussed with available geochronological data set. These findings are significant in relation to structural data and form a part of the geo-structural database for ground surveys.
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Diagnostic value underlies asymmetric updating of impressions in the morality and ability domains.
Mende-Siedlecki, Peter; Baron, Sean G; Todorov, Alexander
2013-12-11
While positive behavioral information is diagnostic when evaluating a person's abilities, negative information is diagnostic when evaluating morality. Although social psychology has considered these two domains as orthogonal and distinct from one another, we demonstrate that this asymmetry in diagnosticity can be explained by a single parsimonious principle--the perceived frequency of behaviors in these domains. Less frequent behaviors (e.g., high ability and low morality) are weighed more heavily in evaluations. We show that this statistical principle of frequency-derived diagnosticity is evident in human participants at both behavioral and neural levels of analysis. Specifically, activity in right ventrolateral prefrontal cortex increased preferentially when participants updated impressions based on diagnostic behaviors, and further, activity in this region covaried parametrically with the perceived frequency of behaviors. Activity in left ventrolateral PFC, left inferior frontal gyrus, and left superior temporal sulcus showed similar patterns of diagnosticity and sensitivity, though additional analyses confirmed that these regions responded primarily to updates based on immoral behaviors.
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Seghedi, I.; Maţenco, L.; Downes, H.; Mason, P.R.D.; Szakács, A.; Pécskay, Z.
2011-01-01
The south-eastern part of the Carpathian–Pannonian region records the cessation of convergence between the European platform/Moesia and the Tisza–Dacia microplate. Plio-Quaternary magmatic activity in this area, in close proximity to the ‘Vrancea zone’, shows a shift from normal calc-alkaline to
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Directory of Open Access Journals (Sweden)
Ashu S Bhalla
2017-01-01
Full Text Available Sarcoidosis is a multi-systemic disorder of unknown etiology, although commonly believed to be immune-mediated. Histologically, it is characterized by noncaseating granuloma which contrasts against the caseating granuloma seen in tuberculosis (TB, an infectious disease that closely mimics sarcoidosis, both clinically as well as radiologically. In TB-endemic regions, the overlapping clinico-radiological manifestations create significant diagnostic dilemma, especially since the management options are markedly different in the two entities. Part 1 of this review aims to summarize the clinical, laboratory, and imaging features of sarcoidosis, encompassing both typical and atypical manifestations, in an attempt to distinguish between the two disease entities.
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Pu, Shenghong; Nakagome, Kazuyuki; Itakura, Masashi; Ohtachi, Hiroaki; Iwata, Masaaki; Nagata, Izumi; Kaneko, Koichi
2018-01-01
Although prior studies identified a relationship between cognitive insight and subjective quality of life (QOL) in patients with schizophrenia, the brain regions mediating this relationship remain unknown. Recent studies have shown that the ventrolateral prefrontal cortex may be particularly important for cognitive insight in individuals with schizophrenia. Here, we examined whether frontotemporal function mediates the relationship between cognitive insight and QOL in 64 participants, including 32 patients with schizophrenia and 32 healthy controls. Cognitive insight was measured using the Beck Cognitive Insight Scale (BCIS), while participants' subjective QOL was assessed using the Medical Outcomes Study 36-item Short-form Health Survey. Frontotemporal function was evaluated during a verbal fluency task using multichannel near-infrared spectroscopy. Consistent with previous findings, we found that frontotemporal function was impaired in patients with schizophrenia. Interestingly, our data also revealed that the right ventrolateral PFC and the right anterior part of the temporal cortex significantly mediated the relationship between the self-reflectiveness (SR) subscale of the BCIS and subjective QOL. These findings suggest that cognitive insight, particularly SR, is associated with subjective QOL in patients with schizophrenia via right frontotemporal function. The findings of this study provide important insight into a QOL model of schizophrenia, which may guide the development of cost-effective interventions that target frontotemporal function in patients with schizophrenia.
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Peled, Ronit; Schenirer, Jerry
2009-10-01
This article describes a systematic process of geographic and strategic planning for healthcare services as a part of a regional development plan in the Israeli Galilee. The planning process consisted of three stages: (a) assessment of needs, demand and existing resources; (b) prioritisation of initiatives; and (c) scheduling of theoretical priorities. For many years the region has suffered from inequities and inequalities regarding the availability and accessibility of a regional healthcare system, resulting in high mortality and morbidity rates and low quality of life. The aim of the healthcare strategic plan was to suggest initiatives and actions to be taken in order to improve healthcare provision and the health and wellbeing of local residents.
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Stress amplifies sex differences in primate prefrontal profiles of gene expression.
Lee, Alex G; Hagenauer, Megan; Absher, Devin; Morrison, Kathleen E; Bale, Tracy L; Myers, Richard M; Watson, Stanley J; Akil, Huda; Schatzberg, Alan F; Lyons, David M
2017-11-02
Stress is a recognized risk factor for mood and anxiety disorders that occur more often in women than men. Prefrontal brain regions mediate stress coping, cognitive control, and emotion. Here, we investigate sex differences and stress effects on prefrontal cortical profiles of gene expression in squirrel monkey adults. Dorsolateral, ventrolateral, and ventromedial prefrontal cortical regions from 18 females and 12 males were collected after stress or no-stress treatment conditions. Gene expression profiles were acquired using HumanHT-12v4.0 Expression BeadChip arrays adapted for squirrel monkeys. Extensive variation between prefrontal cortical regions was discerned in the expression of numerous autosomal and sex chromosome genes. Robust sex differences were also identified across prefrontal cortical regions in the expression of mostly autosomal genes. Genes with increased expression in females compared to males were overrepresented in mitogen-activated protein kinase and neurotrophin signaling pathways. Many fewer genes with increased expression in males compared to females were discerned, and no molecular pathways were identified. Effect sizes for sex differences were greater in stress compared to no-stress conditions for ventromedial and ventrolateral prefrontal cortical regions but not dorsolateral prefrontal cortex. Stress amplifies sex differences in gene expression profiles for prefrontal cortical regions involved in stress coping and emotion regulation. Results suggest molecular targets for new treatments of stress disorders in human mental health.
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Directory of Open Access Journals (Sweden)
Tammy Chung
2015-12-01
Full Text Available This preliminary study examined the extent to which regional brain activation during a reward cue antisaccade (AS task was associated with 6-month treatment outcome in adolescent substance users. Antisaccade performance provides a sensitive measure of executive function and cognitive control, and generally improves with reward cues. We hypothesized that when preparing to execute an AS, greater activation in regions associated with cognitive and oculomotor control supporting AS, particularly during reward cue trials, would be associated with lower substance use severity at 6-month follow-up. Adolescents (n = 14, ages 14–18 recruited from community-based outpatient treatment completed an fMRI reward cue AS task (reward and neutral conditions, and provided follow-up data. Results indicated that AS errors decreased in reward, compared to neutral, trials. AS behavioral performance, however, was not associated with treatment outcome. As hypothesized, activation in regions of interest (ROIs associated with cognitive (e.g., ventrolateral prefrontal cortex and oculomotor control (e.g., supplementary eye field during reward trials were inversely correlated with marijuana problem severity at 6-months. ROI activation during neutral trials was not associated with outcomes. Results support the role of motivational (reward cue factors to enhance cognitive control processes, and suggest a potential brain-based correlate of youth treatment outcome.
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Huang, Shang-Cheng; Dai, Yu-Wen E; Lee, Yen-Hsien; Chiou, Lih-Chu; Hwang, Ling-Ling
2010-08-01
An injection of orexin A or B into the cisterna magna or the rostral ventrolateral medulla (RVLM), where bulbospinal vasomotor neurons are located, elevated arterial pressure (AP) and heart rate (HR). We examined how orexins affected RVLM neurons to regulate cardiovascular functions by using in vitro recordings of neuronal activity of the RVLM and in vivo measurement of cardiovascular functions in rats. Orexin A and B concentration-dependently depolarized RVLM neurons. At 100 nM, both peptides excited 42% of RVLM neurons. Tetrodotoxin failed to block orexin-induced depolarization. In the presence of N-(2-methyl-6-benzoxazolyl)-N'-1, 5-naphthyridin-4-yl urea (SB-334867), an orexin 1 receptor (OX(1)R) antagonist, orexin A depolarized 42% of RVLM neurons with a smaller, but not significantly different, amplitude (4.9 +/- 0.8 versus 7.2 +/- 1.1 mV). In the presence of (2S)-1- (3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride (TCS OX2 29), an orexin 2 receptor (OX(2)R) antagonist, orexin A depolarized 25% of RVLM neurons with a significantly smaller amplitude (1.7 +/- 0.5 mV). Coapplication of both antagonists completely eliminated orexin A-induced depolarization. An OX(2)R agonist, [Ala(11),D-Leu(15)]-orexin B, concentration-dependently depolarized RVLM neurons. Regarding neuronal phenotypes, orexins depolarized 88% of adrenergic, 43% of nonadrenergic, and 36 to 41% of rhythmically firing RVLM neurons. Intracisternal TCS OX2 29 (3 and 10 nmol) suppressed intracisternal orexin A-induced increases of AP and HR, whereas intracisternal SB-334867 (3 and 10 nmol) had no effect on the orexin A-induced increase of HR but suppressed the orexin A-induced pressor response at 10 nmol. We concluded that orexins directly excite RVLM neurons, which include bulbospinal vasomotor neurons, and regulate cardiovascular function mainly via the OX(2)R, with a smaller contribution from the OX(1)R.
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Retrobulbar vs peribulbar regional anesthesia techniques using bupivacaine in dogs.
Shilo-Benjamini, Yael; Pascoe, Peter J; Maggs, David J; Hollingsworth, Steven R; Strom, Ann R; Good, Kathryn L; Thomasy, Sara M; Kass, Philip H; Wisner, Erik R
2018-05-15
To compare the effectiveness of retrobulbar anesthesia (RBA) and peribulbar anesthesia (PBA) in dogs. Six adult mixed-breed dogs (18-24 kg). In a randomized, masked, crossover trial with a 10-day washout period, each dog was sedated with intravenously administered dexmedetomidine and administered 0.5% bupivacaine:iopamidol (4:1) as RBA (2 mL via a ventrolateral site) or PBA (5 mL divided equally between ventrolateral and dorsomedial sites). The contralateral eye acted as control. Injectate distribution was evaluated by computed tomography. Following intramuscularly administered atipamezole, corneal and periocular skin sensation, intraocular pressure (IOP), and ocular reflexes, and appearance were evaluated for 24 hours. Comparisons were performed with mixed-effects linear regression (IOP) or the exact Wilcoxon signed rank test (scores). Significance was set at P ≤ .05. Injectate distribution was intraconal in 2/6 RBA- and 4/6 PBA-injected eyes. Eyes undergoing PBA had significantly reduced lateral, ventral, and dorsal periocular skin sensation for 2-3 hours, and significantly reduced corneal sensitivity for 4 hours, relative to control eyes. Chemosis and exophthalmos occurred in 33%-40% of eyes undergoing RBA and 83%-100% eyes undergoing PBA but resolved within 14 hours. Anterior uveitis developed in 2/6 and 1/6 eyes of RBA and PBA, respectively, of them corneal ulcer developed in one eye of each treatment. Both resolved 1-3 days following medical treatment. Peribulbar injection produced notable anesthesia more reliably than did retrobulbar injection. Both techniques may produce adverse effects, although the uveitis/ulcer could have resulted from the contrast agent used. © 2018 American College of Veterinary Ophthalmologists.
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Beyond the medial regions of prefrontal cortex in the regulation of fear and anxiety
Directory of Open Access Journals (Sweden)
Yoshiro eShiba
2016-02-01
Full Text Available Fear and anxiety are adaptive responses but if left unregulated, or inappropriately regulated, they become biologically and socially maladaptive. Dysregulated emotions are manifest in a wide variety of psychiatric and neurological conditions but the external expression gives little indication of the underlying causes, which are inevitably multi-determined. To go beyond the overt phenotype and begin to understand the causal mechanisms leading to conditions characterized by anxiety and disorders of mood, it is necessary to identify the base psychological processes that have become dysregulated, and map them on to their associated neural substrates. So far, attention has been focused primarily on the medial regions of prefrontal cortex (PFC and in particular their contribution to the expression and extinction of conditioned fear. However, functional neuroimaging studies have shown that the sphere of influence within the PFC is not restricted to its medial regions, but extends into dorsal, ventrolateral (vlPFC and orbitofrontal (OFC regions too; although the causal role of these other areas in the regulation of fear and anxiety remains to be determined and in the case of the OFC, existing findings are conflicting. Here we review the evidence for the contribution of these other regions in negative emotion regulation in rodents and old world and new world monkeys. We consider a variety of different contexts, including conditioned and innate fear, learned and unlearned anxiety and cost-benefit decision-making, and a range of physiological and behavioral measures of emotion. It is proposed that both the OFC and vlPFC contribute to emotion regulation via their involvement, respectively, in the prediction of future outcomes and higher-order attentional control. The fractionation of these neurocognitive and neurobehavioral systems that regulate fear and anxiety opens up new opportunities for diagnostic stratification and personalized treatment strategies.
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Tsai, Ching-Yi; Li, Faith C H; Wu, Carol H Y; Chang, Alice Y W; Chan, Samuel H H
2016-09-22
Small ubiquitin-related modifier (SUMO) is a group of proteins that participates in post-translational modifications. One known SUMO target is the transcription factor nuclear factor-kB (NF-kB) that plays a pivotal role in many disease processes; sumoylation inactivates NF-kB by conjugation with inhibitors of NF-kB (IkB). Our laboratory demonstrated previously that transcriptional upregulation of nitric oxide synthase II (NOS II) by NF-kB, leading to nitrosative stress by the formation of peroxynitrite in the rostral ventrolateral medulla (RVLM), underpins the defunct brain stem cardiovascular regulation that precedes brain death. Based on an experimental endotoxemia model, this study evaluated the hypothesis that sumoylation plays a pro-life role in brain death by interacting with the NF-kB/NOS II/peroxynitrite signaling pathway in the RVLM. In Sprague-Dawley rats, intravenous administration of Escherichia coli lipopolysaccharide (LPS; 10 mg kg -1 ) elicited an augmentation of SUMO-1 and ubiquitin-conjugase 9 (Ubc9) mRNA or protein levels, alongside SUMO-1-conjugated proteins in the RVLM. Immunoneutralization of SUMO-1 or Ubc9 in the RVLM significantly potentiated the already diminished sumoylation of IkBα and intensified NF-kB activation and NOS II/peroxynitrite expression in this brain stem substrate, together with exacerbated fatality, cardiovascular depression and reduction of an experimental index of a life-and-death signal detected from arterial pressure that disappears in comatose patients signifying failure of brain stem cardiovascular regulation before brain death. We conclude that sumoylation of IkB in the RVLM ameliorates the defunct brain stem cardiovascular regulation that underpins brain death in our experimental endotoxemia modal by reducing nitrosative stress via inhibition of IkB degradation that diminishes the induction of the NF-kB/NOS II/peroxynitrite signaling cascade.
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Regional Phenomena of Vertical Deformation in Southern Part of Indonesia
Sarsito, D. A.; Susilo; Andreas, H.; Pradipta, D.; Gumilar, I.
2018-02-01
Distribution of present-day horizontal and vertical deformation across the Southern Part of Indonesia at Java, Bali and Nusa Tenggara now days can be determined from continuous and campaign types of GNSS GPS data monitoring. For vertical deformation in this case we use the continuous types since they are give better quality of data consistency compare to campaign type. Continuous Global Positioning System (CGPS) are maintaining by Geospatial Information Agency for more than a decade. The vertical displacements or velocity rates are estimated from time series analysis after multi-baseline GPS processing using GAMIT-GLOBK software with respect to the latest International Terrestrial Reference Frame. The result shows some interesting phenomena where the northern part of research area majority have negative value that may indicate land subsidence with or without tectonic subsidence combination. In the middle part, the uplift phenomena are clearly shown and in the southern part show combine pattern between uplift and subsidence. The impacts of those phenomena would be discuss also in this paper since many population and infrastructure are located in the areas that will need more protection planning to reduce the negative impact such as earthquake and flooding.
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International Nuclear Information System (INIS)
Gomes, B.M.; Pessenda, L.C.R.; Aravena, R.
1995-01-01
Full text. Numerous studies have focused on the understanding of the vegetation dynamics in the amazon region and its realtion to climate. The research approaches in these studies have involved the use of biological, geomorphologic and botanical tools, (1,2). Our approach involves the use of 13 and 14 C analyses in soil organic mater t infer past vegeation changes in the Amazon region (3). This is based on the distinct composition that characterize the C 3 and C 4 plants, that formed the different vegetation communities that exist in the Amazon region. 14 C used as a dating tool. This paper present data in soils collected in the Rondonia State, located in the northwestern part of the Amazon region. The soils were collected along a transect that include four distinct vegetation communities, ranging from a Cerrado type vegetation (southern part), dominated by C 4 grasses, to a tropical forest (northern part). The soils types are Latossolo Vermelho Amarelo at the Cerrado, Cerrado-transition and forest-transition sites, and Podzolico Vermelho amarelo at the forest site. 14 C data obtained in total soil organic matter, humin fraction and charcoal indicate that the organic matterin these soils is at least Holocene in age. The forest and the forest-transition sites area characterized by typical δ 13 C profiles (-29 to -24 0/00), indicating the predominance of C 3 plants during the past in this region. The Cerrado-transition sites show a significant change in δ 13 C from -27.5 0/00 at the surface to -19 0/00 at 30 cm. This value changed toward more depleted δ 13 C values at the 90-100 cm depth interval, reaching a value of -30 0/00 at 190-200 cm depth interval. This trend has to be associated to a change from a forest type vegetation (190-200 cm to 130-140 cm), to a vegetation community with a mayor influence of C 4 palnts recorded i the interval between 110-120 to 20-23 cm depth. The δ 13 C values at the Cerrado sites are the more enriched ones observed in this study
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Warren, Aaron E L; Abbott, David F; Jackson, Graeme D; Archer, John S
2017-12-01
To identify abnormal thalamocortical circuits in the severe epilepsy of Lennox-Gastaut syndrome (LGS) that may explain the shared electroclinical phenotype and provide potential treatment targets. Twenty patients with a diagnosis of LGS (mean age = 28.5 years) and 26 healthy controls (mean age = 27.6 years) were compared using task-free functional magnetic resonance imaging (MRI). The thalamus was parcellated according to functional connectivity with 10 cortical networks derived using group-level independent component analysis. For each cortical network, we assessed between-group differences in thalamic functional connectivity strength using nonparametric permutation-based tests. Anatomical locations were identified by quantifying spatial overlap with a histologically informed thalamic MRI atlas. In both groups, posterior thalamic regions showed functional connectivity with visual, auditory, and sensorimotor networks, whereas anterior, medial, and dorsal thalamic regions were connected with networks of distributed association cortex (including the default-mode, anterior-salience, and executive-control networks). Four cortical networks (left and right executive-control network; ventral and dorsal default-mode network) showed significantly enhanced thalamic functional connectivity strength in patients relative to controls. Abnormal connectivity was maximal in mediodorsal and ventrolateral thalamic nuclei. Specific thalamocortical circuits are affected in LGS. Functional connectivity is abnormally enhanced between the mediodorsal and ventrolateral thalamus and the default-mode and executive-control networks, thalamocortical circuits that normally support diverse cognitive processes. In contrast, thalamic regions connecting with primary and sensory cortical networks appear to be less affected. Our previous neuroimaging studies show that epileptic activity in LGS is expressed via the default-mode and executive-control networks. Results of the present study suggest that
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Prefrontal inhibition of threat processing protects working memory from interference.
Directory of Open Access Journals (Sweden)
Robert James Clarke
2013-05-01
Full Text Available Bottom-up processes can interrupt ongoing cognitive processing in order to adaptively respond to emotional stimuli of high potential significance, such as those that threaten wellbeing. However it is vital that this interference can be modulated in certain contexts to focus on current tasks. Deficits in the ability to maintain the appropriate balance between cognitive and emotional demands can severely impact on day-to-day activities. This fMRI study examined this interaction between threat processing and cognition; 18 adult participants performed a visuospatial working memory (WM task with two load conditions, in the presence and absence of anxiety induction by threat of electric shock. Threat of shock interfered with performance in the low cognitive load condition; however interference was eradicated under high load, consistent with engagement of emotion regulation mechanisms. Under low load the amygdala showed significant activation to threat of shock that was modulated by high cognitive load. A directed top-down control contrast identified two regions associated with top-down control; ventrolateral PFC and dorsal ACC. Dynamic causal modelling provided further evidence that under high cognitive load, top-down inhibition is exerted on the amygdala and its outputs to prefrontal regions. Additionally, we hypothesised that individual differences in a separate, non-emotional top-down control task would predict the recruitment of dorsal ACC and ventrolateral PFC during top-down control of threat. Consistent with this, performance on a separate dichotic listening task predicted dorsal ACC and ventrolateral PFC activation during high WM load under threat of shock, though activation in these regions did not directly correlate with WM performance. Together, the findings suggest that under high cognitive load and threat, top-down control is exerted by dACC and vlPFC to inhibit threat processing, thus enabling WM performance without threat
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Yilmaz, Lutfu Safak; Atilgan, Ali Rana
2000-09-01
A low-resolution structural model based on the packing geometry of α-carbons is utilized to establish a connection between the flexible and rigid parts of a folded protein. The former commonly recognizes a complementing molecule for making a complex, while the latter manipulates the necessary conformational change for binding. We attempt analytically to distinguish this control architecture that intrinsically exists in globular proteins. First with two-dimensional simple models, then for a native protein, bovine pancreatic trypsin inhibitor, we explicitly demonstrate that inserting fluctuations in tertiary contacts supported by the stable core, one can regulate the displacement of residues on loop regions. The positional fluctuations of the flexible regions are annihilated by the rest of the protein in conformity with the Le Chatelier-Braun principle. The results indicate that the distortion of the principal nonbonded contacts between highly packed residues is accompanied by that of the slavery fluctuations that are widely distributed over the native structure. These positional arrangements do not appear in a reciprocal relation between a perturbation and the associated response; the effect of a movement of residue i on residue j is not equal to that of the same movement of residue j on residue i.
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Energy Technology Data Exchange (ETDEWEB)
Whitaker, R.W.; Noel, S.D.
1992-12-01
The summary report by Tom Weaver gives the overall background for the series of IVE (Integrated Verification Experiment) experiments including information on the full set of measurements made. This appendix presents details of the infrasound data for the and discusses certain aspects of a few special experiments. Prior to FY90, the emphasis of the Infrasound Program was on underground nuclear test (UGT) detection and yield estimation. During this time the Infrasound Program was a separate program at Los Alamos, and it was suggested to DOE/OAC that a regional infrasound network be established around NTS. The IVE experiments took place in a time frame that allowed simultaneous testing of possible network sites and examination of propagation in different directions. Whenever possible, infrasound stations were combined with seismic stations so that a large number could be efficiently fielded. The regional infrasound network was not pursued by DOE, as world events began to change the direction of verification toward non-proliferation. Starting in FY90 the infrasound activity became part of the Source Region Program which has a goal of understanding how energy is transported from the UGT to a variety of measurement locations.
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Gap winds and their effects on regional oceanography Part II: Kodiak Island, Alaska
Ladd, Carol; Cheng, Wei; Salo, Sigrid
2016-10-01
Frequent gap winds, defined here as offshore-directed flow channeled through mountain gaps, have been observed near Kodiak Island in the Gulf of Alaska (GOA). Gap winds from the Iliamna Lake gap were investigated using QuikSCAT wind data. The influence of these wind events on the regional ocean was examined using satellite and in situ data combined with Regional Ocean Modeling System (ROMS) model runs. Gap winds influence the entire shelf width (> 200 km) northeast of Kodiak Island and extend an additional 150 km off-shelf. Due to strong gradients in the along-shelf direction, they can result in vertical velocities in the ocean of over 20 m d-1 due to Ekman pumping. The wind events also disrupt flow of the Alaska Coastal Current (ACC), resulting in decreased flow down Shelikof Strait and increased velocities on the outer shelf. This disruption of the ACC has implications for freshwater transport into the Bering Sea. The oceanographic response to gap winds may influence the survival of larval fishes as Arrowtooth Flounder recruitment is negatively correlated with the interannual frequency of gap-wind events, and Pacific Cod recruitment is positively correlated. The frequency of offshore directed winds exhibits a strong seasonal cycle averaging 7 days per month during winter and 2 days per month during summer. Interannual variability is correlated with the Pacific North America Index and shows a linear trend, increasing by 1.35 days per year. An accompanying paper discusses part I of our study (Ladd and Cheng, 2016) focusing on gap-wind events flowing out of Cross Sound in the eastern GOA.
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Expression of the ghrelin receptor gene in neurons of the medulla oblongata of the rat.
Bron, Romke; Yin, Lei; Russo, Domenico; Furness, John B
2013-08-15
There is ambiguity concerning the distribution of neurons that express the ghrelin receptor (GHSR) in the medulla oblongata. In the current study we used a sensitive nonradioactive method to investigate GHSR mRNA distribution by in situ hybridization. Strong expression of the GHSR gene was confirmed in neurons of the facial nucleus (FacN, 7), the dorsal vagal complex (DVC), and the semicompact (but not compact) nucleus ambiguus (AmbSC and AmbC). In addition, expression of GHSR was found in other regions, where it had not been described before. GHSR-positive neurons were observed in the gustatory rostral nucleus tractus solitarius and in areas involved in vestibulo-ocular processing (such as the medial vestibular nucleus and the nucleus abducens). GHSR expression was also noted in ventral areas associated with cardiorespiratory control, including the gigantocellular reticular nucleus, the lateral paragigantocellular nucleus, the rostral and caudal ventrolateral medulla, the (pre)-Bötzinger complex, and the rostral and caudal ventrolateral respiratory group. However, GHSR-positive neurons in ventrolateral areas did not express markers for cardiovascular presympathetic vasomotor neurons, respiratory propriobulbar rhythmogenic neurons, or sensory interneurons. GHSR-positive cells were intermingled with catecholamine neurons in the dorsal vagal complex but these populations did not overlap. Thus, the ghrelin receptor occurs in the medulla oblongata in 1) second-order sensory neurons processing gustatory, vestibulo-ocular, and visceral sensation; 2) cholinergic somatomotor neurons of the FacN and autonomic preganglionic neurons of the DMNX and AmbSC; 3) cardiovascular neurons in the DVC, Gi, and LPGi; 4) neurons of as yet unknown function in the ventrolateral medulla. Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company.
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Regional homogeneity of resting-state brain abnormalities in bipolar and unipolar depression.
Liu, Chun-Hong; Ma, Xin; Wu, Xia; Zhang, Yu; Zhou, Fu-Chun; Li, Feng; Tie, Chang-Le; Dong, Jie; Wang, Yong-Jun; Yang, Zhi; Wang, Chuan-Yue
2013-03-05
Bipolar disorder patients experiencing a depressive episode (BD-dep) without an observed history of mania are often misdiagnosed and are consequently treated as having unipolar depression (UD), leading to inadequate treatment and poor outcomes. An essential solution to this problem is to identify objective biological markers that distinguish BD-dep and UD patients at an early stage. However, studies directly comparing the brain dysfunctions associated with BD-dep and UD are rare. More importantly, the specificity of the differences in brain activity between these mental disorders has not been examined. With whole-brain regional homogeneity analysis and region-of-interest (ROI) based receiver operating characteristic (ROC) analysis, we aimed to compare the resting-state brain activity of BD-dep and UD patients. Furthermore, we examined the specific differences and whether these differences were attributed to the brain abnormality caused by BD-dep, UD, or both. Twenty-one bipolar and 21 unipolar depressed patients, as well as 26 healthy subjects matched for gender, age, and educational levels, participated in the study. We compared the differences in the regional homogeneity (ReHo) of the BD-dep and UD groups and further identified their pathophysiological abnormality. In the brain regions showing a difference between the BD-dep and UD groups, we further conducted receptive operation characteristic (ROC) analyses to confirm the effectiveness of the identified difference in classifying the patients. We observed ReHo differences between the BD-dep and UD groups in the right ventrolateral middle frontal gyrus, right dorsal anterior insular, right ventral anterior insular, right cerebellum posterior gyrus, right posterior cingulate cortex, right parahippocampal gyrus, and left cerebellum anterior gyrus. Further ROI comparisons and ROC analysis on these ROIs showed that the right parahippocampal gyrus reflected abnormality specific to the BD-dep group, while the right
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Vos, Janet R; Teixeira, Natalia; van der Kolk, Dorina M; Mourits, Marian J E; Rookus, Matti A; van Leeuwen, Flora E; Collée, Margriet; van Asperen, Christi J; Mensenkamp, Arjen R; Ausems, Margreet G E M; van Os, Theo A M; Meijers-Heijboer, Hanne E J; Gómez-Garcia, Encarna B; Vasen, Hans F; Brohet, Richard M; van der Hout, Annemarie H; Jansen, Liesbeth; Oosterwijk, Jan C; de Bock, Geertruida H
2014-11-01
We aimed to quantify previously observed relatively high cancer risks in BRCA2 mutation carriers (BRCA2 carriers) older than 60 in the Northern Netherlands, and to analyze whether these could be explained by mutation spectrum or population background risk. This consecutive cohort study included all known pathogenic BRCA1/2 carriers in the Northern Netherlands (N = 1,050). Carrier and general reference populations were: BRCA1/2 carriers in the rest of the Netherlands (N = 2,013) and the general population in both regions. Regional differences were assessed with HRs and ORs. HRs were adjusted for birth year and mutation spectrum. All BRCA1 carriers and BRCA2 carriers younger than 60 had a significantly lower breast cancer risk in the Northern Netherlands; HRs were 0.66 and 0.64, respectively. Above age 60, the breast cancer risk in BRCA2 carriers in the Northern Netherlands was higher than in the rest of the Netherlands [HR, 3.99; 95% confidence interval (CI), 1.11-14.35]. Adjustment for mutational spectrum changed the HRs for BRCA1, BRCA2 <60, and BRCA2 ≥60 years by -3%, +32%, and +11% to 0.75, 0.50, and 2.61, respectively. There was no difference in background breast cancer incidence between the two regions (OR, 1.03; 95% CI, 0.97-1.09). Differences in mutation spectrum only partly explain the regional differences in breast cancer risk in BRCA2 carriers, and for an even smaller part in BRCA1 carriers. The increased risk in BRCA2 carriers older than 60 may warrant extension of intensive breast screening beyond age 60. ©2014 American Association for Cancer Research.
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Directory of Open Access Journals (Sweden)
Marie-José van Tol
2014-01-01
Discussion: Results suggest that STG GM abnormalities underlie the general susceptibility to experience psychotic symptoms and that additional abnormalities in a network of medial temporal, ventrolateral, putaminal, and parietal regions related to verbal memory and speech production may specifically increase the likelihood of experiencing AVH. Future studies should clarify the meaning of morphometry abnormalities for functional interregional communication.
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Energy Technology Data Exchange (ETDEWEB)
Labs, K.
The regional suitability of underground construction as a climate-control technique is discussed with reference to (1) a bioclimatic analysis of long-term weather data for 29 locations in the United States to determine appropriate above-ground climate-control techniques, (2) a data base of synthesized ground temperatures for the coterminous United States, and (3) monthly dewpoint ground temperature comparisons for identifying the relative likelihood of condensation, from one region to another. It is concluded that the suitability of earth tempering as a practice and of specific earth-sheltered design stereotypes varies geographically. While the subsurface almost always provides a thermal advantage on its own terms when compared to above-ground climatic data, it can, nonetheless, compromise the effectiveness of other, regionally more important climate-control techniques. Also contained in the report are reviews of above- and below-ground climate mapping schemes related to human comfort and architectural design, and a detailed description of a theoretical model of ground temperature, heat flow, and heat storage in the ground. Strategies of passive climate control are presented in a discussion of the building bioclimatic analysis procedure which has been applied in a computer analysis of 30 years of weather data for each of 29 locations in the United States. 3 references, 12 figures, 14 tables.
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REGIONAL ECONOMIC GROWTH THROUGH TOURISM. THE CASE OF REGION WEST
Directory of Open Access Journals (Sweden)
Dragoi Ionut
2010-12-01
Full Text Available The regional development should aim to correlate and integrate tourism among the other integrative parts of the regional and local development, taking into account the fact that a region’s prosperity as effect of tourism development may be shown clearly in several stages: on the spot (as a result of direct consumption of the tourist product, on short term (through continuous absorption of the work-force and encouraging the welcoming commerce and in the long run (concentrating capital for investment in the general infrastructure and the one of tourism, in structures of reception for tourism and in the development of urban services. The analysis of intra-regional disparities as part of the economic growth at the level of Region West starts off with the idea that each component county has a different landscape, which favored or inhibited their economic growth; in the same time, each component county has its own specific, which can be promoted through tourism, inducing in time a regional income, and respectively, a social-economic and cultural growth of less developed areas.
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Organotypic slice cultures containing the preBötzinger complex generate respiratory-like rhythms
DEFF Research Database (Denmark)
Phillips, Wiktor S; Herly, Mikkel; Del Negro, Christopher A
2016-01-01
containing the preBötzinger complex (preBötC), the core inspiratory rhythm generator of the ventrolateral brainstem. We measured bilateral synchronous network oscillations, using calcium-sensitive fluorescent dyes, in both ventrolateral (presumably the preBötC) and dorsomedial regions of 7-43 days in vitro......Acute brainstem slice preparations in vitro have advanced understanding of the cellular and synaptic mechanisms of respiratory rhythm generation, but their inherent limitations preclude long-term manipulation and recording experiments. Here, we developed an organotypic slice culture preparation...... of the brainstem displayed up to 193% faster burst frequency (22.4 ± 8.3 bursts/min) and higher signal amplitude (340%) compared to acute slices. We conclude that preBötC-containing slice cultures retain inspiratory-like rhythmic function and therefore may facilitate lines of experimentation that involve extended...
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The tectopontine projection the the rat with comments on visual pathways to the basilar pons
International Nuclear Information System (INIS)
Burne, R.A.; Azizi, S.A.; Mihailoff, G.A.; Woodward, D.J.
1981-01-01
The projection from the superior and inferior colliculi to the basilar pons in the rat was studied with the technique of orthograde transport of labeled amino acids and autoradiography. Injections restricted to the medial or lateral regions of the superior colliculus gave rise to grain labeling representing terminal fields over the ipsilateral peduncular, dorsolateral, and ventrolateral regions of the caudal basilar pons and over the dorsomedial area of the contralateral nucleus reticularis tegmenti pontis (NRTP). The pontine projection from the superior colliculus to the lateral basilar pons is topographically organized; the medial superior colliculus projects primarily to the peduncular region, whereas the lateral superior colliculus terminates chiefly in ventrolateral pontine areas. A projection from the superior colliculus to the contralateral dorsomedial pontine and medial peduncular pontine regions, a previously undescribed finding, has also been shown. Descending fibers from the inferior colliculus do not appear to terminate extensively within the basilar pons but rather course adjacent to pontine cells of the dorsolateral region in the caudal pons. Pretectal nuclei project ipsilaterally to medial and lateral nuclei in the rostral and middle basilar pons, respectively. A rostrocaudal topography exists in the tectopontine projection; the pretectum projects to rostromiddle basilar pons, the superior colliculus to more caudal pontine regions, and the inferior colliculus (although sparsely) to further caudal areas. The pontine projection pattern from the colliculi and pretectum differs from the pontine afferents from the visual cortices
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19 CFR 10.600 - Accessories, spare parts, or tools.
2010-04-01
...-Central America-United States Free Trade Agreement Rules of Origin § 10.600 Accessories, spare parts, or... parts, or tools are customary for the good. (a) Regional value content. If the good is subject to a regional value content requirement, the value of the accessories, spare parts, or tools is taken into...
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Morinaga, Ryosuke; Nakamuta, Nobuaki; Yamamoto, Yoshio
2016-10-01
Hypoxia induces respiratory responses in mammals and serotonergic neurons in the medulla oblongata participate in respiratory control. However, the morphological changes in serotonergic neurons induced by hypoxia have not yet been examined and respiratory controls of serotonergic neurons have not been clarified. We herein investigated the distribution of immunoreactivity for serotonin (5-hydroxytryptamine; 5-HT) in the medulla oblongata of control rats and rats exposed to 1-6h of hypoxia (10% O 2 ). We also examined the medulla oblongata by multiple immunofluorescence labeling for 5-HT, neurokinin 1 receptors (NK1R), a marker for some respiratory neurons in the pre-Bötzinger complex (PBC), and dopamine β-hydroxylase (DBH), a marker for catecholaminergic neurons. The number of 5-HT-immunoreactive nerve cell bodies in the raphe nuclei was higher in rats exposed to hypoxia than in control rats. The number of 5-HT-immunoreactive nerve fibers significantly increased in the rostral ventrolateral medulla of rats exposed to 1-6h of hypoxia, caudal ventrolateral medulla of rats exposed to 2-6h of hypoxia, and lateral part of the nucleus of the solitary tract and dorsal motor nucleus of the vagus nerve of rats exposed to 1-2h of hypoxia. Multiple immunofluorescence labeling showed that 5-HT-immunoreactive nerve fibers were close to NK1R-immunoreactive neurons in ventrolateral medulla and to DBH-immunoreactive neurons in the medulla. These results suggest that serotonergic neurons partly regulate respiratory control under hypoxic conditions by modulating the activity of NK1R-expressing and catecholaminergic neurons. Copyright © 2016 Elsevier GmbH. All rights reserved.
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Analysis of regional climate strategies in the Barents region
Energy Technology Data Exchange (ETDEWEB)
Himanen, S.; Inkeroeinen, J.; Latola, K.; Vaisanen, T.; Alasaarela, E.
2012-11-15
Climate change is a global phenomenon with especially harsh effects on the Arctic and northern regions. The Arctic's average temperature has risen at almost twice the rate as elsewhere in the past few decades. Since 1966, the Arctic land area covered by snow in early summer has shrunk by almost a fifth. The Barents Region consists of the northern parts of Norway, Sweden, Finland and Russia (i.e. the European part of Russia). Climate change will cause serious impacts in the Barents Region because of its higher density of population living under harsh climatic conditions, thus setting it apart from other Arctic areas. In many cases, economic activities, like tourism, rely on certain weather conditions. For this reason, climate change and adaptation to it is of special urgency for the region. Regional climate change strategies are important tools for addressing mitigation and adaptation to climate change as they can be used to consolidate the efforts of different stakeholders of the public and private sectors. Regional strategies can be important factors in achieving the national and international goals. The study evaluated how the national climate change goals were implemented in the regional and local strategies and programmes in northern Finland. The specific goal was to describe the processes by which the regional strategies were prepared and implemented, and how the work was expanded to include the whole of northern Finland. Finally, the Finnish preparatory processes were compared to case examples of processes for preparing climate change strategies elsewhere in the Barents Region. This analysis provides examples of good practices in preparing a climate change strategy and implementing it. (orig.)
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Regional Development Planning in the Slovak Republic
Rentková, Katarína
2017-10-01
Regional development is very closely related to a region and its competitive advantages which affect the competitiveness of the region. The regional development is influenced by many factors that act differently depending on the region. To ensure the effective and harmonized regional development, the systematic approach is needed. Every region is unique and differs from the other by the level of economic development, living standards of its inhabitants, unemployment rate and by employment possibilities. Regional policy is a strategic investment policy which focuses on all regions and cities in the European Union. The aim is to boost economic growth and to improve the quality of people’s lives. Solidarity is the main feature of the policy, because policy focuses on support for less developed regions. A fundamental aspect of regional development is to reduce disparities between the regions and cities. The paper focuses on the analysis of regional development of Slovakia. The intention is to follow the logical continuity of the article’s parts, the correctness and the adequacy of information and data. First part is focused on the definition of the regional policy and regional development. Important task is to identify the differences between European policies - regional, structural and cohesion policy. This section is prepared by using the analytical methods - the analysis, the casual and historical analysis. This part is based on literature review. The empirical part is based on statistics and secondary analysis which were aimed to analyse the regional development and effectiveness of its planning in the Slovak Republic. The question of this article is whether it is possible to plan the regional development by application of the plan for economic and social development, called the Municipal Development Plan.
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[Study on the area of pain and numbness in cases with lumbosacral radiculopathy].
Kuraishi, Keita; Hanakita, Junya; Takahashi, Toshiyuki; Minami, Manabu; Watanabe, Mizuki; Uesaka, Toshio; Honda, Fumiaki
2012-10-01
In the clinical diagnosis of lumbosacral radicular symptoms, dermatome maps are commonly used, by which the segmental location of the affected nerve can be determined. However, the diagnosis is often difficult because the pattern of sensory disturbance does not necessarily match the patterns of classical dermatomes, and there are many dermatome maps made by different methods. The author examined the area of pain and numbness in cases of lumbosacral radiculopathy. Clinical features of pain and numbness in consecutive seventy three cases of lumbosacral radiculopathy were investigated (L3: n=13, L4-S1: n=20). Patients of L3 radiculopathy showed symptoms at the upper buttock and ventral surface of the thighs, knees and upper ventral surface of the legs. Patients of L4 radiculopathy showed symptoms at the ventro-lateral surfaces of the thigh and leg. The distinctive region, defined as the region having 100% superimposition, of L4 radiculopathy was the lateral part of the shin. Patients of L5 radiculopathy showed symptoms at the lateral surfaces of the thigh and leg. The distinctive region was the upper buttock. Patients of S1 radiculopathy showed symptoms at the lower buttock, dorso-lateral part of the leg and lateral part of the foot. The distinctive region was the lateral part of the calf. It was found that the regions of pain and numbness formed a continuous band-like zone from thigh to leg in 8% of L3, 45% of L4 and L5, and 35% of S1 radiculopathy. Using a visual analogue scale, the degree of leg pain was more severe than low back pain in 68% of the patients, but in 5% of patients, low back pain was more severe.
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Regional flow and solute transport modeling for site suitability. Part I
International Nuclear Information System (INIS)
Rowe, J.; Miller, I.
1979-12-01
The nature of regional flow systems in large sedimentary basins will largely determine the effectiveness of regional flow as a barrier to radionuclide escape from deep geologic repositories. The purpose of the work reported herein and the proposed future work is to develop a methodology for evaluating regional flow barriers by using numerical models. The Williston Basin was chosen as an archetype case for the regional modeling study. However, due to the simplified nature of the study, the results are not meant to represent the behavior of a repository actually placed within the Williston Basin. The major components of this Phase I study are: (1) assembly and reduction of available data; (2) formulation of a simplified geohydrologic model; (3) computer simulation of fluid flow; and (4) computer simulation of solute transport. As of this report, the first two items are essentially completed. Computer simulation of fluid flow will require some revision and further study, which will be done in the second phase of this study. Computer simulation of solute transport has been considered only on a very preliminary basis. Important conclusions of this Phase I study are as follows. Assembly and reduction of data require an extensive work effort. Generally, the parameters describing fluid flow are poorly known on a regional basis and those describing solute transport are unknown
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Regional flow and solute transport modeling for site suitability. Part I
Energy Technology Data Exchange (ETDEWEB)
Rowe, J.; Miller, I.
1979-12-01
The nature of regional flow systems in large sedimentary basins will largely determine the effectiveness of regional flow as a barrier to radionuclide escape from deep geologic repositories. The purpose of the work reported herein and the proposed future work is to develop a methodology for evaluating regional flow barriers by using numerical models. The Williston Basin was chosen as an archetype case for the regional modeling study. However, due to the simplified nature of the study, the results are not meant to represent the behavior of a repository actually placed within the Williston Basin. The major components of this Phase I study are: (1) assembly and reduction of available data; (2) formulation of a simplified geohydrologic model; (3) computer simulation of fluid flow; and (4) computer simulation of solute transport. As of this report, the first two items are essentially completed. Computer simulation of fluid flow will require some revision and further study, which will be done in the second phase of this study. Computer simulation of solute transport has been considered only on a very preliminary basis. Important conclusions of this Phase I study are as follows. Assembly and reduction of data require an extensive work effort. Generally, the parameters describing fluid flow are poorly known on a regional basis and those describing solute transport are unknown.
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Insertion and crossing region design
International Nuclear Information System (INIS)
Wienands, U.; Beloshitsky, P.
2001-01-01
This article is the summary of the 5-afternoon tutorial on insertions for circular machines. Roughly half the course (Part 1) was spent discussing interaction regions, We start by recapitulating basic beam optics including building blocks. This provides the tools to analyze the basic structure of interaction regions and explore the parameter space. This simple example is then successively refined and made more realistic. Examples of realized interaction regions for both hadron and electron machines are shown and their salient features and differences explained. A brief discussion of solenoid-decoupling brings Part 1 to a close. In Part 2 we discussed various utility sections. Dispersion suppressors are presented in detail discussing the principles as well as the practical implementation of flexible suppressors using LEP as an example. Injection schemes, both single-turn and multi-turn stacking, are presented in depth. The matching of wiggler and undulator insertions and a discussion of the impact of these devices on beam parameters closes out Part 2
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Directory of Open Access Journals (Sweden)
Wu Kay LH
2012-08-01
Full Text Available Abstract Background Estrogen acts on the rostral ventrolateral medulla (RVLM, where sympathetic premotor neurons are located, to elicit vasodepressor effects via an estrogen receptor (ERβ-dependent mechanism. We investigated in the present study nontranscriptional mechanism on cardiovascular effects following activation of ERβ in the RVLM, and delineated the involvement of phosphatidylinositol 3-kinase (PI3K/serine/threonine kinase (Akt signaling pathway in the effects. Methods In male Sprague–Dawley rats maintained under propofol anesthesia, changes in arterial pressure, heart rate and sympathetic neurogenic vasomotor tone were examined after microinjection bilaterally into RVLM of 17β-estradiol (E2β or a selective ERα or ERβ agonist. Involvement of ER subtypes and PI3K/Akt signaling pathway in the induced cardiovascular effects were studied using pharmacological tools of antagonists or inhibitors, gene manipulation with antisense oligonucleotide (ASON or adenovirus-mediated gene transfection. Results Similar to E2β (1 pmol, microinjection of ERβ agonist, diarylpropionitrile (DPN, 1, 2 or 5 pmol, into bilateral RVLM evoked dose-dependent hypotension and reduction in sympathetic neurogenic vasomotor tone. These vasodepressive effects of DPN (2 pmol were inhibited by ERβ antagonist, R,R-tetrahydrochrysene (50 pmol, ASON against ERβ mRNA (250 pmol, PI3K inhibitor LY294002 (5 pmol, or Akt inhibitor (250 pmol, but not by ERα inhibitor, methyl-piperidino-pyrazole (1 nmol, or transcription inhibitor, actinomycin D (5 or 10 nmol. Gene transfer by microinjection into bilateral RVLM of adenovirus encoding phosphatase and tensin homologues deleted on chromosome 10 (5 × 108 pfu reversed the vasodepressive effects of DPN. Conclusions Our results indicate that vasodepressive effects following activation of ERβ in RVLM are mediated by nongenomic activation of PI3K/Akt signaling pathway. This study provides new insight in the
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[Changes of regional environment quality pattern in China since 1986-2008].
Guan, Wei-Hua; Sun, Ming-Kun; Lu, Yu-Qi
2011-03-01
For further study of regional differences and the pattern of changes in environmental quality in China since 1986-2008, we perform the principal component analysis, standard deviation, Mann-Kendall and cluster analysis on 18 environmental quality indexes in 28 provinces of China in this paper. Those indexes refer to pollutant emission, pollutants treatment capacities and pollutant emission of per unit land area, etc. The paper indicates that regional environmental quality in China has been increased slightly during this period. It can be divided into four stages: 1986-2000, 2000-2001, 2001-2005 and 2005-2008. The overall patterns of regional environmental quality is the West is higher than the East in general, while the environmental quality of the eastern part have been changed somewhat. For more details, the regional environmental quality in China in 1986 is composed of two parts, the eastern part and the western part, while in 2000 and 2001 the eastern part, the middle part and the western part appears as the overall pattern. For the year of 2005, the regional environmental quality in the western is higher than that of the eastern; meanwhile, the eastern can be divided into the northern part, the middle part and the southern part, and the environmental quality in northern part is better than that of the southern part, southern part is better than that of the middle part. This pattern hardly changed in 2008, except that the area with poor environment quality region had expanded. Pollutant emission of per unit land area played as a main factor; yet both the pollutant emission and the reuse of pollutants impacted the pattern specifically. In addition, the national macro policies, the regional policies, the regional economic and the industrial structure can be primary reason for the change of regional environmental quality pattern in China as well.
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International Nuclear Information System (INIS)
Boyle, C.M.; Hidalgo, S.P.; Martinez, B.J.
2004-01-01
The Controlled Parts Management (CPM) system is based on industry standard practices for managing inventory. CPM is designed to record the movement of any type of inventory in a defined region referred to as an Account or SubAccount. The system is used to track the receiving, processing, storing and transfer of inventory parts. CPM provides information on parts, quantity and the exact location of the inventory. CPM is a barcode-based-part tracking system currently used to track controlled parts that are used in the R and D and testing of weapons; this tracking helps maintain the part pedigree that is required for certification of a weapon or weapon test. CPM includes bar code data collection software programmed into portable bar code readers for automating physical inventory services and remote transaction capture. CPM interfaces to other Engineering systems and supports a 'material content' of a weapons test through the test Bill of Materials and assignment of a unique inventory part in CPM. Additional functionality includes the ability to group or join parts, logically or physically and temporary or permanent, to represent discrete parts, containers, subassemblies and assemblies, and groupings.
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Directory of Open Access Journals (Sweden)
Sander M Daselaar
2013-02-01
Full Text Available In functional neuroimaging studies, ventral parietal cortex (VPC is recruited by very different cognitive tasks. Explaining the contributions VPC to these tasks has become a topic of intense study and lively debate. Perception studies frequently find VPC activations during tasks involving attention-reorienting, and memory studies frequently find them during tasks involving episodic recollection. According to the Attention to Memory (AtoM model, both phenomena can be explained by the same VPC function: bottom-up attention. Yet, a recent functional MRI (fMRI meta-analysis suggested that attention-reorienting activations are more frequent in anterior VPC, whereas recollection activations are more frequent in posterior VPC. Also, there is evidence that anterior and posterior VPC regions have different functional connectivity patterns. To investigate these issues, we conducted a resting-state functional connectivity analysis using as seeds the center-of-mass of attention-reorienting and recollection activations in the meta-analysis, which were located in the supramarginal gyrus (SMG, around the temporo-parietal junction—TPJ and in the angular gyrus (AG, respectively. The SMG seed showed stronger connectivity with ventrolateral prefrontal cortex (VLPFC and occipito-temporal cortex, whereas the AG seed showed stronger connectivity with the hippocampus and default network regions. To investigate whether these connectivity differences were graded or sharp, VLPFC and hippocampal connectivity was measured in VPC regions traversing through the SMG and AG seeds. The results showed a graded pattern: VLPFC connectivity gradually decreases from SMG to AG, whereas hippocampal connectivity gradually increases from SMG to AG. Importantly, both gradients showed an abrupt break when extended beyond VPC borders. This finding suggests that functional differences between SMG and AG are more subtle than previously thought. These connectivity differences can be
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UN’ANALISI DEI FLUSSI FINANZIARI DELLA REGIONE SICILIA
Greco, Maria Giuseppina; Torrisi, Gianpiero
2009-01-01
The paper presents an analysis of (Italian region) Sicilia’s financial flows using data from Regional Public Accounts. The paper is divided into two main parts. The first part of the work considers financial flows as a whole. The second part considers more in detail expenditure and revenue both in current and in capital account. The analysis shows that Sicilian regional data are characterised by similarities as well as peculiar aspects with respect both to national aggregate and the Southern ...
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Study of diffuse H II regions potentially forming part of the gas streams around Sgr A*
Armijos-Abendaño, J.; López, E.; Martín-Pintado, J.; Báez-Rubio, A.; Aravena, M.; Requena-Torres, M. A.; Martín, S.; Llerena, M.; Aldás, F.; Logan, C.; Rodríguez-Franco, A.
2018-05-01
We present a study of diffuse extended ionized gas towards three clouds located in the Galactic Centre (GC). One line of sight (LOS) is towards the 20 km s-1 cloud (LOS-0.11) in the Sgr A region, another LOS is towards the 50 km s-1 cloud (LOS-0.02), also in Sgr A, while the third is towards the Sgr B2 cloud (LOS+0.693). The emission from the ionized gas is detected from Hnα and Hmβ radio recombination lines (RRLs). Henα and Hemβ RRL emission is detected with the same n and m as those from the hydrogen RRLs only towards LOS+0.693. RRLs probe gas with positive and negative velocities towards the two Sgr A sources. The Hmβ to Hnα ratios reveal that the ionized gas is emitted under local thermodynamic equilibrium conditions in these regions. We find a He to H mass fraction of 0.29±0.01 consistent with the typical GC value, supporting the idea that massive stars have increased the He abundance compared to its primordial value. Physical properties are derived for the studied sources. We propose that the negative velocity component of both Sgr A sources is part of gas streams considered previously to model the GC cloud kinematics. Associated massive stars with what are presumably the closest H II regions to LOS-0.11 (positive velocity gas), LOS-0.02, and LOS+0.693 could be the main sources of ultraviolet photons ionizing the gas. The negative velocity components of both Sgr A sources might be ionized by the same massive stars, but only if they are in the same gas stream.
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Kostopoulos, Penelope; Petrides, Michael
2016-02-16
There is evidence from the visual, verbal, and tactile memory domains that the midventrolateral prefrontal cortex plays a critical role in the top-down modulation of activity within posterior cortical areas for the selective retrieval of specific aspects of a memorized experience, a functional process often referred to as active controlled retrieval. In the present functional neuroimaging study, we explore the neural bases of active retrieval for auditory nonverbal information, about which almost nothing is known. Human participants were scanned with functional magnetic resonance imaging (fMRI) in a task in which they were presented with short melodies from different locations in a simulated virtual acoustic environment within the scanner and were then instructed to retrieve selectively either the particular melody presented or its location. There were significant activity increases specifically within the midventrolateral prefrontal region during the selective retrieval of nonverbal auditory information. During the selective retrieval of information from auditory memory, the right midventrolateral prefrontal region increased its interaction with the auditory temporal region and the inferior parietal lobule in the right hemisphere. These findings provide evidence that the midventrolateral prefrontal cortical region interacts with specific posterior cortical areas in the human cerebral cortex for the selective retrieval of object and location features of an auditory memory experience.
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American Red Cross Chapter Regions
Department of Homeland Security — The Regions are part of the national field level structure to support chapters. The Regions role is admistrative as well as provides oversight and program technical...
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International Nuclear Information System (INIS)
1997-01-01
This report contains two separate parts: Characterization of the Radon Source in North-Central Florida (final report part 1 -- final project report); and Characterization of the Radon Source in North-Central Florida (technical report). The objectives were to characterize the radon 222 source in a region having a demonstrated elevated indoor radon potential and having geology, lithology, and climate that are different from those in other regions of the U.S. where radon is being studied. Radon availability and transport in this region were described. Approaches for predicting the radon potential of lands in this region were developed
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Directory of Open Access Journals (Sweden)
Seung Hee Cho
2017-12-01
Full Text Available Regulatory RNA regions within a transcript, particularly in the 5′ untranslated region (5′UTR, have been shown in a variety of organisms to control the expression levels of these mRNAs in response to various metabolites or environmental conditions. Considering the unique tolerance of Zymomonas mobilis to ethanol and the growing interest in engineering microbial strains with enhanced tolerance to industrial inhibitors, we searched natural cis-regulatory regions in this microorganism using transcriptomic data and bioinformatics analysis. Potential regulatory 5′UTRs were identified and filtered based on length, gene function, relative gene counts, and conservation in other organisms. An in vivo fluorescence-based screening system was developed to confirm the responsiveness of 36 5′UTR candidates to ethanol, acetate, and xylose stresses. UTR_ZMO0347 (5′UTR of gene ZMO0347 encoding the RNA binding protein Hfq was found to down-regulate downstream gene expression under ethanol stress. Genomic deletion of UTR_ZMO0347 led to a general decrease of hfq expression at the transcript level and increased sensitivity for observed changes in Hfq expression at the protein level. The role of UTR_ZMO0347 and other 5′UTRs gives us insight into the regulatory network of Z. mobilis in response to stress and unlocks new strategies for engineering robust industrial strains as well as for harvesting novel responsive regulatory biological parts for controllable gene expression platforms in this organism.
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International Nuclear Information System (INIS)
Proulx, M.U.; Nicolet, R.; Dufour, J.
1998-01-01
On July 19 and 20 of 1996, torrential rains provoked catastrophic floods in the Saguenay Region of Quebec. The overflowing waters of the region's rivers damaged 3000 residential buildings, completely destroyed another 426, and seriously affected the activities of 850 business establishments. In this comprehensive report, the physical causes and the social, economic, psychological, cultural, political and administrative consequences of this natural catastrophe are discussed by several experts. The report is divided into three parts. The first part describes the actual flooding conditions and the immediate response of local emergency services such as the Red Cross and the Saint-Vincent-de-Paul agencies. Reactions of the various public agencies and governments to the disaster are described in Part Two. Part Three of the document focuses on lessons to be drawn from this natural disaster, in particular the need to improve emergency relief strategies. The legal implications and consequences of the disaster are also discussed. refs., tabs., figs
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Giardia agilis: Ultrastructure of the Trophozoites in the Frog Intestine
Directory of Open Access Journals (Sweden)
Maria Inês L Sogayar
1998-05-01
Full Text Available Intestine samples of Bufo sp. tadpoles with parasitism confirmed for Giardia agilis were studied by transmission electron microscopy. The G. agilis trophozoites were long and thin. The plasma membrane was sometimes undulated and the cytoplasm, adjacent to the dorsal and ventral regions, showed numerous vacuoles. The two nuclei presented prominent nucleoli. The cytoplasm was electron-dense with free ribosomes, glycogen and rough endoplasmic reticulum-like structures. Polyhedral inclusions were observed in the cytoplasm and outside the protozoan; some of these inclusions exhibited membrane disruption. The flagella ultrastructure is typical, with the caudal pair accompanied by the funis. Next to the anterior pair, osmiophilic material was noticed. The ventro-lateral flange was short and thick, supported by the marginal plates that penetrated into its distal extremity; only its distal portion had adjacent osmiophilic filament. The G. agilis trophozoites showed the general subcellular feature of the genus. However, the ventro-lateral flange ultrastructure was an intermediate type between G. muris and G. duodenalis.
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Fos expression in the midbrain periaqueductal grey after trigeminovascular stimulation
Hoskin, KL; Bulmer, DCE; Lasalandra, M; Jonkman, A; Goadsby, PJ
There is an accumulating body of evidence suggesting that the periaqueductal grey (PAG) is involved in the pathophysiology of migraine. Positron emission tomography (PET) studies in humans have shown that the caudal ventrolateral midbrain, encompassing the ventrolateral PAG, has activations during
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Spatially Rearranged Object Parts Can Facilitate Perception of Intact Whole Objects
Directory of Open Access Journals (Sweden)
Laura eCacciamani
2014-05-01
Full Text Available The familiarity of an object depends on the spatial arrangement of its parts; when the parts are spatially rearranged, they form a novel, unrecognizable configuration. Yet the same collection of parts comprises both the familiar and novel configuration. Is it possible that the collection of familiar parts activates a representation of the intact familiar configuration even when they are spatially rearranged? We presented novel configurations as primes before test displays that assayed effects on figure-ground perception from memories of intact familiar objects. In our test displays, two equal-area regions shared a central border; one region depicted a portion of a familiar object. Previous research with such displays has shown that participants are more likely to perceive the region depicting a familiar object as the figure and the abutting region as its ground when the familiar object is depicted in its upright orientation rather than upside down. The novel primes comprised either the same or a different collection of parts as the familiar object in the test display (part-rearranged and control primes, respectively. We found that participants were more likely to perceive the familiar region as figure in upright vs. inverted displays following part-rearranged primes but not control primes. Thus, priming with a novel configuration comprising the same familiar parts as the upcoming figure-ground display facilitated orientation-dependent effects of object memories on figure assignment. Similar results were obtained when the spatially rearranged collection of parts was suggested on the groundside of the prime’s border, suggesting that familiar parts in novel configurations access the representation of their corresponding intact whole object before figure assignment. These data demonstrate that familiar parts access memories of familiar objects even when they are arranged in a novel configuration.
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Spatially rearranged object parts can facilitate perception of intact whole objects.
Cacciamani, Laura; Ayars, Alisabeth A; Peterson, Mary A
2014-01-01
The familiarity of an object depends on the spatial arrangement of its parts; when the parts are spatially rearranged, they form a novel, unrecognizable configuration. Yet the same collection of parts comprises both the familiar and novel configuration. Is it possible that the collection of familiar parts activates a representation of the intact familiar configuration even when they are spatially rearranged? We presented novel configurations as primes before test displays that assayed effects on figure-ground perception from memories of intact familiar objects. In our test displays, two equal-area regions shared a central border; one region depicted a portion of a familiar object. Previous research with such displays has shown that participants are more likely to perceive the region depicting a familiar object as the figure and the abutting region as its ground when the familiar object is depicted in its upright orientation rather than upside down. The novel primes comprised either the same or a different collection of parts as the familiar object in the test display (part-rearranged and control primes, respectively). We found that participants were more likely to perceive the familiar region as figure in upright vs. inverted displays following part-rearranged primes but not control primes. Thus, priming with a novel configuration comprising the same familiar parts as the upcoming figure-ground display facilitated orientation-dependent effects of object memories on figure assignment. Similar results were obtained when the spatially rearranged collection of parts was suggested on the groundside of the prime's border, suggesting that familiar parts in novel configurations access the representation of their corresponding intact whole object before figure assignment. These data demonstrate that familiar parts access memories of familiar objects even when they are arranged in a novel configuration.
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1990-01-01
This Magellan radar image is of part of the Phoebe region of Venus. It is a mosaic of parts of revolutions 146 and 147 acquired in the first radar test on Aug. 16, 1990. The area in the image is located at 291 degrees east longitude, 19 degrees south latitude. The image shows an area 30 kilometers (19.6 miles) wide and 76 km (47 miles) long. On the basis of Pioneer Venus and Arecibo data, it is known that two major rift zones occur in southern Phoebe Regio and that they terminate at about 20 to 25 degrees south latitude, about 2,000 km (1,240 miles) apart. This image is of an area just north of the southern end of the western rift zone. The region is characterized by a complex geologic history involving both volcanism and faulting. Several of the geologic units show distinctive overlapping or cross cutting relationships that permit identification and separation of geologic events and construction of the geologic history of the region. The oldest rocks in this image form the complexly deformed and faulted, radar bright, hilly terrain in the northern half. Faults of a variety of orientations are observed. A narrow fault trough (about one-half to one km (three tenths to six tenths of a mile) wide is seen crossing the bright hills near the lower part in the middle of the image. This is one of the youngest faults in the faulted, hilly unit as it is seen to cut across many other structures. The fault trough in turn appears to be embayed and flooded by the darker plains that appear in the south half of the image. These plains are interpreted to be of volcanic origin. The dark plains may be formed of a complex of overlapping volcanic flows. For example, the somewhat darker region of plains in the lower left (southwest) corner of the image may be a different age series of plains forming volcanic lava flows. Finally, the narrow bright line crossing the image in its lower part is interpreted to be a fault which cross cuts both plains units and is thus the youngest event in
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Allen, A M; Chai, S Y; Clevers, J; McKinley, M J; Paxinos, G; Mendelsohn, F A
1988-03-08
Angiotensin II receptor and angiotensin converting enzyme distributions in the human medulla oblongata were localised by quantitative in vitro autoradiography. Angiotensin II receptors were labelled with the antagonist analogue 125I-[Sar1, Ile8] AII while angiotensin converting enzyme was labelled with 125I-351A, a derivative of the specific converting enzyme inhibitor, lisinopril. Angiotensin II receptor binding and angiotensin converting enzyme are present in high concentrations in the nucleus of the solitary tract, the dorsal motor nucleus of vagus, the rostral and caudal ventrolateral reticular nucleus, and in a band connecting the dorsal and ventral regions. In the rostral and caudal ventrolateral reticular nucleus, angiotensin II receptors are distributed in a punctate pattern that registers with neuronal cell bodies. The distribution and density of these cell bodies closely resemble those of catecholamine-containing neurones mapped by others. In view of the known interactions of angiotensin II with both central and peripheral catecholamine-containing neurons of laboratory animals, the current anatomical findings suggest similar interactions between these neuroactive compounds in the human central nervous system. The presence of angiotensin II receptors and angiotensin converting enzyme in the nucleus of the solitary tract, dorsal motor nucleus of vagus, and rostral and caudal ventrolateral reticular nucleus demonstrates sites for central angiotensin II to exert its known actions on vasopressin release and autonomic functions including blood pressure control. These data also suggest a possible interaction between angiotensin II and central catecholeminergic systems.
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Reward-dependent modulation of working memory in lateral prefrontal cortex.
Kennerley, Steven W; Wallis, Jonathan D
2009-03-11
Although research implicates lateral prefrontal cortex (PFC) in executive control and goal-directed behavior, it remains unclear how goals influence executive processes. One possibility is that goal-relevant information, such as expected rewards, could modulate the representation of information relating to executive control, thereby ensuring the efficient allocation of cognitive resources. To investigate this, we examined how reward modulated spatial working memory. Past studies investigating spatial working memory have focused on dorsolateral PFC, but this area only weakly connects with areas processing reward. Ventrolateral PFC has better connections in this regard. Thus, we contrasted the functional properties of single neurons in ventrolateral and dorsolateral PFC as two subjects performed a task that required them to hold spatial information in working memory under different expectancies of reward for correct performance. We balanced the order of presentation of spatial and reward information so we could assess the neuronal encoding of the two pieces of information independently and conjointly. Neurons in ventrolateral PFC encoded both spatial and reward information earlier, stronger and in a more sustained manner than neurons in dorsolateral PFC. Within ventrolateral PFC, spatial selectivity was more prevalent on the inferior convexity than within the principal sulcus. Finally, when reward increased spatial selectivity, behavioral performance improved, whereas when reward decreased spatial selectivity, behavioral performance deteriorated. These results suggest that ventrolateral PFC may be a locus whereby information about expected rewards can modulate information in working memory. The pattern of results is consistent with a role for ventrolateral PFC in attentional control.
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Han, Fei
2014-01-01
We present two modeling approaches for predicting the macroscopic elastic properties of carbon nanotubes/polymer composites with thick interphase regions at the nanotube/matrix frontier. The first model is based on local continuum mechanics; the second one is based on hybrid local/non-local continuum mechanics. The key computational issues, including the peculiar homogenization technique and treatment of periodical boundary conditions in the non-local continuum model, are clarified. Both models are implemented through a three-dimensional geometric representation of the carbon nanotubes network, which has been detailed in Part I. Numerical results are shown and compared for both models in order to test convergence and sensitivity toward input parameters. It is found that both approaches provide similar results in terms of homogenized quantities but locally can lead to very different microscopic fields. © 2013 Elsevier B.V. All rights reserved.
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Sinjab, Barah; Martinian, Lillian; Sisodiya, Sanjay M; Thom, Maria
2013-01-01
Purpose Clinical, experimental, and neuroimaging data all indicate that the thalamus is involved in the network of changes associated with temporal lobe epilepsy (TLE), particularly in association with hippocampal sclerosis (HS), with potential roles in seizure initiation and propagation. Pathologic changes in the thalamus may be a result of an initial insult, ongoing seizures, or retrograde degeneration through reciprocal connections between thalamic and limbic regions. Our aim was to carry out a neuropathologic analysis of the thalamus in a postmortem (PM) epilepsy series, to assess the distribution, severity, and nature of pathologic changes and its association with HS. Methods Twenty-four epilepsy PM cases (age range 25–87 years) and eight controls (age range 38–85 years) were studied. HS was classified as unilateral (UHS, 11 cases), bilateral (BHS, 4 cases) or absent (No-HS, 9 cases). Samples from the left and right sides of the thalamus were stained with cresyl violet (CV), and for glial firbillary acidic protein (GFAP) and synaptophysin. Using image analysis, neuronal densities (NDs) or field fraction staining values (GFAP, synaptophysin) were measured in four thalamic nuclei: anteroventral nucleus (AV), lateral dorsal nucleus (LD), mediodorsal nucleus (MD), and ventrolateral nucleus (VL). The results were compared within and between cases. Key Findings The severity, nature, and distribution of thalamic pathology varied between cases. A pattern that emerged was a preferential involvement of the MD in UHS cases with a reduction in mean ND ipsilateral to the side of HS (p = 0.05). In UHS cases, greater field fraction values for GFAP and lower values for synaptophysin and ND were seen in the majority of cases in the MD ipsilateral to the side of sclerosis compared to other thalamic nuclei. In addition, differences in the mean ND between classical HS, atypical HS, and No-HS cases were noted in the ipsilateral MD (p < 0.05), with lower values observed in
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Analyzing the impact of conjunctive labeling as part of a regional wine branding strategy
Directory of Open Access Journals (Sweden)
Tom Atkin
2017-12-01
Full Text Available Research studies have proven that place-based/regional branding methods have a positive effect on brand equity and economic benefits for companies. However, very small or specific regions may be confusing to consumers, so conjunctive labeling â or the process of advertising both a larger region and the sub-region of origin for a product â is suggested as a remedy for this situation. This study analyzes the impact of conjunctive labeling by comparing two national samples of consumers, before and two years after, conjunctive wine labeling was introduced in Sonoma County. The results show a higher awareness for both Sonoma County and its sub appellations (AVAs after conjunctive labeling was introduced than before. This demonstrates the potential benefit of associating sub-regional appellations with larger wine regions. Keywords: Regional branding, Appellations, Wine marketing, Conjunctive labeling, Place-based marketing
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Security assurances and regional stability
International Nuclear Information System (INIS)
Sanders, B.
1995-01-01
This paper discusses whether and how security assurances affect political stability in geographic regions. Before embarking on what is necessarily a limited analysis of a complex subject, I point out that the subject is by no means new. For centuries, vast areas of the world have been affected by forces used against them by more powerful States, which at one time or another incorporated large parts of them into overseas colonies or contiguous empires. The new factors are the emancipation of those areas into independent regions, made up of States that play their own parts in international affairs, and the possession by a handful of Powers, outside or on the edge of those regions, of a specific form of superior force: nuclear weapons. (author)
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Population development in Ljubljana urban region
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Dejan Rebernik
2004-12-01
Full Text Available The paper presents the main characteristic of population development and urbanisation processes in Ljubljana and Ljubljana urban region. Up to the end of the seventies fast population growth was a consequence of strong immigration from rural parts of Slovenia and the rest of Yugoslavia. In the eighties and nineties deconcentration of population within the region with intense suburbanisation and depopulation of inner city and older residential neighbourhoods were the main urbanisation processes. In the second half of the nineties the highest population growth was recorded in dispersed rural settlements in the periphery of the region. In some parts of the inner city reurbanisation and gentrification occurred.
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Senda, Joe; Kato, Shigenori; Kaga, Tomotsugu; Ito, Mizuki; Atsuta, Naoki; Nakamura, Tomohiko; Watanabe, Hirohisa; Tanaka, Fumiaki; Naganawa, Shinji; Sobue, Gen
2011-01-01
We investigated 17 patients with sporadic amyotrophic lateral sclerosis (ALS) using voxel-based morphometry (VBM) and voxel-based analysis of diffusion tensor images (DTI) at baseline and after a six-month follow-up. Compared with 17 healthy controls, ALS patients at baseline showed only minimal white matter volume decreases in the inferior frontal gyrus but marked decreases in the gray matter of several regions, especially in the bilateral paracentral lobule of the premotor cortex. DTI revealed reduced fractional anisotropy in the bilateral corticospinal tracts, insula, ventrolateral premotor cortex, and parietal cortex. Increased mean diffusivity was noted bilaterally in the motor cortex, ventrolateral premotor cortex, insula, hippocampal formation, and temporal gyrus. At the six-month follow-up, ALS patients showed widespread volume decreases in gray matter, and DTI abnormalities extended mainly into the bilateral frontal lobes, while volume changes in the white matter remained minimal but more distinct. Our combined VBM and DTI techniques revealed extra-corticospinal tract neuronal degeneration mainly in the frontotemporal lobe of ALS patients. In particular, follow-up examinations in these patients showed that whole-brain DTI changes occurred predominantly in the regions of brain atrophy. These objective analyses can be used to assess the disease condition of the ALS brain.
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DEFF Research Database (Denmark)
Hansen, Teis
2013-01-01
to assess the progress of integration in the regions, as well as the effect of cross-border innovation policies. Consequently, important questions are left unanswered, including the central research question of this paper: does the sudden removal of significant physical barriers directly impacts......The topics of regional innovation systems (RIS) and cross-border regions attract increasing attention, but few studies combine the themes. Further, the existing empirical studies of cross-border innovation and knowledge creation analyse one case at one point in time, thus, making it difficult...... collaboration activity in cross-border innovation systems? This paper examines regional integration in the Oresund Region over time. It deals with a specific part of the RIS, as it analyses research collaboration between actors from the Danish and Swedish sides, with a specific emphasis on the biotech industry...
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The Regional Hearing Clerk receives filings for proceedings under the Consolidated Rules of Practice Governing the Administrative Assessment of Civil Penalties and the Revocation/Termination or Suspension of Permits, 40 Code of Federal Regulations Part 22
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Directory of Open Access Journals (Sweden)
G. Walker
2009-10-01
Full Text Available Aerosol perturbations over selected land regions are imposed in Version-4 of the Goddard Earth Observing System (GEOS-4 general circulation model (GCM to assess the influence of increasing aerosol concentrations on regional circulation patterns and precipitation in four selected regions: India, Africa, and North and South America. Part 1 of this paper addresses the responses to aerosol perturbations in India and Africa. This paper presents the same for aerosol perturbations over the Americas. GEOS-4 is forced with prescribed aerosols based on climatological data, which interact with clouds using a prognostic scheme for cloud microphysics including aerosol nucleation of water and ice cloud hydrometeors. In clear-sky conditions the aerosols interact with radiation. Thus the model includes comprehensive physics describing the aerosol direct and indirect effects on climate (hereafter ADE and AIE respectively. Each simulation is started from analyzed initial conditions for 1 May and was integrated through June-July-August of each of the six years: 1982–1987 to provide a 6-ensemble set. Results are presented for the difference between simulations with double the climatological aerosol concentration and one-half the climatological aerosol concentration for three experiments: two where the ADE and AIE are applied separately and one in which both the ADE and AIE are applied. The ADE and AIE both yield reductions in net radiation at the top of the atmosphere and surface while the direct absorption of shortwave radiation contributes a net radiative heating in the atmosphere. A large net heating of the atmosphere is also apparent over the subtropical North Atlantic Ocean that is attributable to the large aerosol perturbation imposed over Africa. This atmospheric warming and the depression of the surface pressure over North America contribute to a northward shift of the inter-Tropical Convergence Zone over northern South America, an increase in
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Directory of Open Access Journals (Sweden)
E. M. Wilcox
2009-10-01
Full Text Available Aerosol perturbations over selected land regions are imposed in Version-4 of the Goddard Earth Observing System (GEOS-4 general circulation model (GCM to assess the influence of increasing aerosol concentrations on regional circulation patterns and precipitation in four selected regions: India, Africa, and North and South America. Part 1 of this paper addresses the responses to aerosol perturbations in India and Africa. This paper presents the same for aerosol perturbations over the Americas. GEOS-4 is forced with prescribed aerosols based on climatological data, which interact with clouds using a prognostic scheme for cloud microphysics including aerosol nucleation of water and ice cloud hydrometeors. In clear-sky conditions the aerosols interact with radiation. Thus the model includes comprehensive physics describing the aerosol direct and indirect effects on climate (hereafter ADE and AIE respectively. Each simulation is started from analyzed initial conditions for 1 May and was integrated through June-July-August of each of the six years: 1982–1987 to provide a 6-ensemble set. Results are presented for the difference between simulations with double the climatological aerosol concentration and one-half the climatological aerosol concentration for three experiments: two where the ADE and AIE are applied separately and one in which both the ADE and AIE are applied. The ADE and AIE both yield reductions in net radiation at the top of the atmosphere and surface while the direct absorption of shortwave radiation contributes a net radiative heating in the atmosphere. A large net heating of the atmosphere is also apparent over the subtropical North Atlantic Ocean that is attributable to the large aerosol perturbation imposed over Africa. This atmospheric warming and the depression of the surface pressure over North America contribute to a northward shift of the inter-Tropical Convergence Zone over northern South America, an increase in
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Controversies regarding decentralism, regionalism, and local governance in Serbia
Directory of Open Access Journals (Sweden)
Mitrović Milovan M.
2002-01-01
Full Text Available The article is composed from three parts. In the first part, I emphasize the importance of theoretical and sociological discussion for the design of the model of social system reforms and stress the problems that occur in Serbia with regard to this. In the second part, I discuss public controversies regarding decentralism, regionalism, and local governance in Serbia. I advocate for regionalism that is closer to local then to para-state governance and argue for the advantages of alternative model of 'functional autonomy of different tempo', that could harmonize inherited historical geopolitical, economic, and cultural differences and reconcile current political antagonisms in Serbia. In the third part I give a proposition that envisages central (Republic administration and local (municipal and city self-governance as main levels of territorial organization of governance (with original authorities, while federal and regional levels would be complementary with it, not parallel. In that sense, I propose 15 autonomous regions for Serbia, with possibility of making 4 to 6 larger regions out of them, at different pace.
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Kotubejová, Karina
2017-01-01
This thesis addresses position of Iran in the Middle East and is trying to find out whether Iran is regional power or not. In the first part the key concepts for defining regional power are explained. Because of absence of unified view on phenomenon of regional power, our own characteristics of it are introduced. Second part is focused on Iran and its position as an actor of international relations in five areas: identity, geopolitical position, foreign policy, regional security and economy. ...
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International Nuclear Information System (INIS)
1977-09-01
In enacting the Energy Reorganization Act of 1974, Congress included Section 206 which requires the reporting of defects and noncompliances directly to the Nuclear Regulatory Commission (NRC). This congressional action required that the NRC promulgate rules and regulations, as necessary, to assure appropriate implementation of Section 206. In response to this mandate, the NRC drafted a new regulation. Following a period of public comment and revision, the regulation identified as 10 CFR Part 21, Reporting Defects and Noncompliance, was published in a Federal Register Notice on June 6, 1977. To assist NRC licensees and other firms and organizations covered by the new Part 21 regulation, public regional meetings were conducted by staff representatives to explain the rule. At these meetings the staff presented prepared remarks and answered questions on the meaning and application of the rule. Staff remarks contained in the original publication of this document were also provided to those in attendance. At each meeting the staff received a request for the questions and answers discussed by the staff to be made available for use as guidance by the nuclear industry covered by the rule. It was announced that a consolidation of the staff position question/answer guidance would be made available to each organization or firm attending these meetings and for others where a request is made in accordance with the directions printed insidethe front cover of the document. The staff will be guided in its implementation and enforcement of Part 21 by the positions set forth in the document. The revision of NUREG-0302 includes the following three parts relating to 10 CFR Part 21: (1) remarks presented by staff representatives; (2) Federal Register Notice material; and (3) a consolidation of questions and answers from the public regional meetings
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Nuclear reactor with scrammable part length rod
International Nuclear Information System (INIS)
Bevilacqua, F.
1979-01-01
A new part length rod is provided. It may be used to control xenon induced power oscillations but to contribute to shutdown reactivity when a rapid shutdown of the reactor is required. The part length rod consists of a control rod with three regions. The lower control region is a longer weaker active portion separated from an upper stronger shorter poison section by an intermediate section which is a relative non-absorber of neutrons. The combination of the longer weaker control section with the upper high worth poison section permits the part length rod of this to be scrammed into the core when a reactor shutdown is required but also permits the control rod to be used as a tool to control power distribution in both the axial and radial directions during normal operation
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A Declining Region: Provincial Renaissance Revisited (Case of Volgograd Region
Directory of Open Access Journals (Sweden)
Drozdova Yuliya
2014-12-01
exceeds incoming migrants. Young people under 35 showed the highest rate of willingness to leave the region – 57.6 % of respondents, which arouses concern about the region’s future as this cohort capable of developing the region is the target of all plans about boosting the regional image, and these people are not going to cast in their lot with the Volgograd region. For the moment, we can point out that the region shows poor attractiveness for the main target groups in the region, which encumbers the formation of the region’s image and regional identity, indicates negative tendencies and implies great effort on the part of management entities if they want to change the situation in the Volgograd region. Our study revealed the main trends in building a positive image of the region and changing the local context; these are traditional (centre of war and history memorials – 38 % of respondents, industrial – 46.0 % of respondents, tourism – 26.8 % of respondents, and innovative (centre for training and education – 35.5 %, centre for culture – 37.9 % of respondents. The regional image and local context do not change spontaneously; they are rather a product of conscious, well-regulated conceptualization, a product of artificially organized public reflection and projection. According to the surveyed people residing in the region, the region’s development and change in local context can be helped along by such factors as “active cooperation of the authorities and business – 49.3 % of respondents; “honesty among regional and municipal officials – 38.6 % of respondents; “safety of business operations” – 34.3 % of respondents; “presence of a regional strategy that meets the region’s needs” – 33.9 % of respondents; “social and tax benefits” – 33.0 % of respondents; “the people should be informed about the project of regional development and take part in them” – 26.8 % of respondents. Revealing the factors that determine the local
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Yamaguchi, Katsuyuki
2018-04-04
The lateral geniculate nucleus (LGN) is the major relay center of the visual pathway in humans. There are few quantitative data on the morphology of LGN in prenatal infants. In this study, using serial brain sections, the author investigated the morphology of this nucleus during the second half of fetal period. Eleven human brains were obtained at routine autopsy from preterm infants aged 20-39 postmenstrual weeks. After fixation, the brain was embedded en bloc in celloidin and cut serially at 30 μm in the horizontal plane. The sections were stained at regular intervals using the Klüver-Barrera method. At 20-21 weeks, the long axis of LGN declined obliquely from the vertical to horizontal plane, while a deep groove was noted on the ventro-lateral surface of the superior half. At this time, an arcuate cell-sparse zone appeared in the dorso-medial region, indicating the beginning of lamination. From 25 weeks onwards, the magnocellular and parvocellular layers were distinguishable, and the characteristic six-layered structure was recognized. The magnocellular layer covered most of the dorsal surface, and parts of the medial, lateral, and inferior surfaces but not the ventral and superior surfaces. Nuclear volume increased exponentially with age during 20-39 weeks, while the mean neuronal profile area increased linearly during 25-39 weeks. Human LGN develops a deep groove on the ventro-lateral surface at around mid-gestation, when the initial lamination is recognized in the prospective magnocellular layer. Thereafter, the nuclear volume increases with age in an exponential function. Copyright © 2018 Elsevier B.V. All rights reserved.
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Motor Functions of the Broca's Region
Binkofski, Ferdinand; Buccino, Giovanni
2004-01-01
Broca's region in the dominant cerebral hemisphere is known to mediate the production of language but also contributes to comprehension. This region evolved only in humans and is constituted of Brodmann's areas 44 and 45 in the inferior frontal gyrus. There is, however, evidence that Broca's region overlaps, at least in part, with the ventral…
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29 CFR 102.4 - Region; subregion.
2010-07-01
... 29 Labor 2 2010-07-01 2010-07-01 false Region; subregion. 102.4 Section 102.4 Labor Regulations Relating to Labor NATIONAL LABOR RELATIONS BOARD RULES AND REGULATIONS, SERIES 8 Definitions § 102.4 Region; subregion. The term region as used herein shall mean that part of the United States or any Territory thereof...
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Mycological discoveries in the Middle East region in the second part of the last century
Directory of Open Access Journals (Sweden)
Mouchacca J
2016-12-01
Full Text Available The arid Middle East extends over 9 million km² in the Eastern part of the Mediterranean Sea. Interest in the fungi of this region after the Second World War led to the discovery of species then regarded as being new to Science. A scan of the Index of Fungi issued in the period running from 1940-2000 revealed that 240 novel taxa had then been proposed. The recorded novelties were examined following the chronology of their introduction, their distribution in the local fifteen political states and their gross taxonomic characters at the Class level. These new additions were characterised at the rate of 40 units / decade. Most originated from Egypt, Iraq and the Palestine-Israel area and relate to the Classes Mitosporic Fungi, Ascomycetes and Basidiomycetes. All together 145 generic names are reported in this group of novelties; twelve were based on type material collected in Egypt (5 genera, the Palestine-Israel area, Iraq, Kuwait, Lebanon and Sudan. The present group of novelties was also surveyed in relation to the nature of the substrate sustaining the selected holotypes. The relevant Mitosporic fungi (93 taxa were equally isolated from soil or from living or decaying plant parts. For Ascomycetous novelties (86 taxa, although their soil-borne elements outnumber the plant related ones, several also developed on other types of substrates. In the case of novel Basidiomycetes (37 taxa, the plant-parasitic species encompass those collected on the ground surface. Finally, a limited number of these novelties disclosed notable thermotolerant abilities and some even qualify as thermophiles. The main features of these novel records underlines that in Egypt more attention was awarded to the local Mitosporic fungi and to Ascomycetes inhabiting its soil-borne communities. For the Basidiomycetes (sensu lato marked interest developed solely in the Palestine-Israel area while in Iraq taxonomic studies focussed on Ascomycetes including those developing on dung
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Early correlates of visual awareness following orientation and colour rivalry.
Veser, Sandra; O'Shea, Robert P; Schröger, Erich; Trujillo-Barreto, Nelson J; Roeber, Urte
2008-10-01
Binocular rivalry occurs when dissimilar images are presented to corresponding retinal regions of the two eyes: visibility alternates irregularly between the two images, interspersed by brief transitions when parts of both may be visible. We measured event-related potentials (ERPs) following binocular rivalry by changing the stimulus viewed by one eye to be identical to that in the other eye, eliciting binocular fusion. Because of the rivalry, observers either saw the change, when it happened to the visible stimulus, or did not see the change, when it happened to the invisible stimulus. The earliest ERP differences between visible and invisible changes occurred after about 100 ms (P1) when the rivalry was between stimuli differing in orientation, and after about 200 ms (N1) when the rivalry was between stimuli differing in colour. These differences originated from ventro-lateral temporal and prefrontal areas. We conclude that the rivalling stimulus property influences the timing of modulation of correlates of visual awareness in a property-independent cortical network.
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International Nuclear Information System (INIS)
Heritage, A.S.; Stumpf, W.E.; Sar, M.; Grant, L.D.
1981-01-01
A combined formaldehyde-induced fluorescence (FIF)-autoradiography procedure was used to determine how and where the androgen, dihydrotestosterone (DHT), is associated with catecholamine systems in the rat brain. With this dual localization method, ( 3 H)-DHT target sites can be visualized in relation to catecholamine perikarya and terminals. In the hindbrain, catecholamine neurons adjacent to the fourth ventricle (group A4), the nucleus (n.) olivaris superior (group A5), the n. parabranchialis medialis (group A7), and in the locus coeruleus (group A6) and subcoeruleal regions, as well as in the substantia grisea centralis, concentrate ( 3 H)-DHT in their nuclei. ( 3 H)-DHT target neurons appear to be innervated by numerous catecholamine terminals in the following hindbrain regions: n. motorius dorsalis nervi vagi, n. tractus solitarii, n. commissuralis, n. raphe pallidus, n. olivaris inferior, the ventrolateral portion of the substantia grisea centralis, n. cuneiformis, and the ventrolateral reticular formation in the caudal mesencephalon. In the forebrain, ( 3 H)-DHT concentrates in nuclei of catecholamine neurons located in the n. arcuatus and n. periventricularis (group A12). In addition, ( 3 H)-DHT target neurons appear to be innervated by numerous catecholamine terminals in the following forebrain regions: n. periventricularis rotundocellularis, n. paraventricularis, n. dorsomedialis, n. periventricularis, area retrochiasmatica, n. interstititalis striae terminalis (ventral portion), and n. amygdaloideus centralis. The disclosure of a morphologic association between ( 3 H)-DHT target sites and certain brain catecholamine systems suggests a close functional interdependence between androgens and catecholamines
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Contemporary Determinants of the Development of Socio-Economic Regions
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Czyż Teresa
2014-06-01
Full Text Available This article examines the effect on the development of socio-economic regions in Poland of contemporary external determinants considered at the European and the world scale. It consists of two parts. The first gives a description of the main general processes that are external determinants of regional development today: modernisation changes, globalisation, metropolitanisation, and European integration. Part two is empirical in character and seeks to find regional manifestations and effects of those determinants in Poland, and to establish how they influence regional income and spatial differences in its value.
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Directory of Open Access Journals (Sweden)
Robert R. Bakhtiev
2013-01-01
Full Text Available The article considers the basic ways of improving management quality via a regional innovation development based on the correlation analysis. The necessity of formation of qualitative information interaction of parts of a regional innovation system is proved. It allows creating more effective innovation process in the region.
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International Nuclear Information System (INIS)
Oros, E.; Popa, M.; Moldovan, I. A.
2008-01-01
The most comprehensive seismological database for Banat seismic region (Romania) has been achieved. This paper refers to the essential characteristics of the first component of this database, namely the Parametric Earthquakes Catalogue for the Banat Seismic Region (PECBSR). PECBSR comprises 7783 crustal earthquakes (3 ≤ h ≤ 25 km) with 0.4 ≤ M i ≥ 5.6 (M i is M L , M D , M S , M W , Mm and/or mb from compiled sources) occurred in the Banat region and its surroundings between years 1443 and 2006. Different magnitude scales were converted into moment magnitude scale, Mw. The completeness of PECBSR strongly depends on the time. (authors)
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Evaluation of the deformation parameters of the northern part of Eg
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Abdel-Monem S. Mohamed
2016-06-01
Full Text Available The northern part of Egypt is a rapidly growing development accompanied by the increased levels of standard living particularly in its urban areas. From tectonic and seismic point of views, the northern part of Egypt is one of the interested regions. It shows an active geologic structure attributed to the tectonic movements of the African and Eurasian plates from one side and the Arabian plate from the other side. From historical point of view and recent instrumental records, the northern part of Egypt is one of the seismo-active regions in Egypt. The investigations of the seismic events and their interpretations had led to evaluate the seismic hazard for disaster mitigation, for the safety of the densely populated regions and the vital projects. In addition to the monitoring of the seismic events, the most powerful technique of Global Navigation Satellite System (GNSS will be used in determining crustal deformation where a geodetic network covers the northern part of Egypt. Joining the GPS Permanent stations of the northern part of Egypt with the Southern part of Europe will give a clear picture about the recent crustal deformation and the African plate velocity. The results from the data sets are compared and combined in order to determine the main characteristics of the deformation and hazard estimation for specified regions. Final compiled output from the seismological and geodetic analysis will throw lights upon the geodynamical regime of these seismo-active regions. This work will throw lights upon the geodynamical regime and to delineate the crustal stress and strain fields in the study region. This also enables to evaluate the active tectonics and surface deformation with their directions from repeated geodetic observations. The results show that the area under study suffers from continuous seismic activity related to the crustal movements taken place along trends of major faults
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Evaluation of the deformation parameters of the northern part of Eg
Mohamed, Abdel-Monem S.; Radwan, Ali M.; Sharf, Mohamed; Hamimi, Zakaria; Hegazy, Esraa E.; Abou Aly, Nadia; Gomaa, Mahmoud
2016-06-01
The northern part of Egypt is a rapidly growing development accompanied by the increased levels of standard living particularly in its urban areas. From tectonic and seismic point of views, the northern part of Egypt is one of the interested regions. It shows an active geologic structure attributed to the tectonic movements of the African and Eurasian plates from one side and the Arabian plate from the other side. From historical point of view and recent instrumental records, the northern part of Egypt is one of the seismo-active regions in Egypt. The investigations of the seismic events and their interpretations had led to evaluate the seismic hazard for disaster mitigation, for the safety of the densely populated regions and the vital projects. In addition to the monitoring of the seismic events, the most powerful technique of Global Navigation Satellite System (GNSS) will be used in determining crustal deformation where a geodetic network covers the northern part of Egypt. Joining the GPS Permanent stations of the northern part of Egypt with the Southern part of Europe will give a clear picture about the recent crustal deformation and the African plate velocity. The results from the data sets are compared and combined in order to determine the main characteristics of the deformation and hazard estimation for specified regions. Final compiled output from the seismological and geodetic analysis will throw lights upon the geodynamical regime of these seismo-active regions. This work will throw lights upon the geodynamical regime and to delineate the crustal stress and strain fields in the study region. This also enables to evaluate the active tectonics and surface deformation with their directions from repeated geodetic observations. The results show that the area under study suffers from continuous seismic activity related to the crustal movements taken place along trends of major faults
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The regional energy integration: the latin-american experiences
International Nuclear Information System (INIS)
2003-01-01
The ways of the regional economic integrations are not identical and generate different repercussions on the markets and the energy industries evolution. The example of the Latin America proposes many various experiences to evaluate the stakes and the limits of each regional integrations. These limits lead to solution researches including indisputable convergencies. The first part of this document presents the genesis of these regional economic integrations experiences in Latina America, to study in the second part the energy consequences of the liberal ALENA and of the more political MERCOSUR. (A.L.B.)
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Neural computations mediating one-shot learning in the human brain.
Directory of Open Access Journals (Sweden)
Sang Wan Lee
2015-04-01
Full Text Available Incremental learning, in which new knowledge is acquired gradually through trial and error, can be distinguished from one-shot learning, in which the brain learns rapidly from only a single pairing of a stimulus and a consequence. Very little is known about how the brain transitions between these two fundamentally different forms of learning. Here we test a computational hypothesis that uncertainty about the causal relationship between a stimulus and an outcome induces rapid changes in the rate of learning, which in turn mediates the transition between incremental and one-shot learning. By using a novel behavioral task in combination with functional magnetic resonance imaging (fMRI data from human volunteers, we found evidence implicating the ventrolateral prefrontal cortex and hippocampus in this process. The hippocampus was selectively "switched" on when one-shot learning was predicted to occur, while the ventrolateral prefrontal cortex was found to encode uncertainty about the causal association, exhibiting increased coupling with the hippocampus for high-learning rates, suggesting this region may act as a "switch," turning on and off one-shot learning as required.
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A limnological survey of the Alligator Rivers Region. 1. Diatoms (Bacillariophyceae) of the region
International Nuclear Information System (INIS)
Thomas, D.P.
1983-08-01
This study was undertaken as part of a study of the algae of the Alligator Rivers Region in general, and of the Magela Creek in particular, to support an investigation into the possible use of native algae as an indicator of any changes in water quality which might occur as a result of uranium mining and milling in the Region
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Long-Term Potentiation in the Motor Cortex
Iriki, Atsushi; Pavlides, Constantine; Keller, Asaf; Asanuma, Hiroshi
1989-09-01
Long-term potentiation (LTP) is a model for learning and memory processes. Tetanic stimulation of the sensory cortex produces LTP in motor cortical neurons, whereas tetanization of the ventrolateral nucleus of the thalamus, which also projects to the motor cortex, does not. However, after simultaneous high-frequency stimulation of both the sensory cortex and the ventrolateral nucleus of the thalamus, LTP of thalamic input to motor cortical neurons is induced. This associative LTP occurs only in neurons in the superficial layers of the motor cortex that receive monosynaptic input from both the sensory cortex and the ventrolateral nucleus of the thalamus. Associative LTP in the motor cortex may constitute a basis for the retention of motor skills.
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Jaber, Omar I; Kirby, Patricia A
2015-11-01
Alveolar soft part sarcoma is a rare neoplasm usually arising in the soft tissues of the lower limbs in adults and in the head and neck region in children. It presents primarily as a slowly growing mass or as metastatic disease. It is characterized by a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in fusion of the transcription factor E3 (TFE3) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25. This translocation is diagnostically useful because the tumor nuclei are positive for TFE3 by immunohistochemistry. Real-time polymerase chain reaction to detect the ASPSCR1-TFE3 fusion transcript on paraffin-embedded tissue blocks has been shown to be more sensitive and specific than detection of TFE3 by immunohistochemical stain. Cathepsin K is a relatively recent immunohistochemical stain that can aid in the diagnosis. The recent discovery of the role of the ASPSCR1-TFE3 fusion protein in the MET proto-oncogene signaling pathway promoting angiogenesis and cell proliferation offers a promising targeted molecular therapy.
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Directory of Open Access Journals (Sweden)
A.A. Hasso
2015-06-01
Full Text Available Twenty two tongues of buffalo collected from the slaughter house of Mousl city (11 tongues for adult animals 3-4 years and11tongues for small ages 1 weake-2 monthes. Two groups were used in this study, twelve samples for anatomical study and ten samples for histological study, in each group of this study, the tongues were divided into four regions from apex to the end of the root. The tongue is a muscular organ which consists of dorsal and ventral surfaces, it is formed from three parts (apex, body and root. The lingual fossa and torus linguae both appear on the dorsal surface. The total average of the tongue length in adult animals (36.00±0.97 cm while the highest average of the length, width and thickness found in the third region. The total length in small ages was (16.92±0.98 cm and the highest average of length and thickness again it happens in third region and the highest width in this age group found in the second region. The investigation of the normal anatomical structures of the tongue distinguished four lingual papillae (filiform, fungiform, conical and circumvalate while the lenticuler papillae absent in both age groups. The filiform and fungiform papillae spread over the dorsal surface and ventro-lateral surface terminat abruptly at the ventro-lateral border forming a distinct straight line from apex to the torus linguae in both ages. The present work reveals that the highest average of filiform papillae in both surface (dorsal and ventro-lateral surface founds in second region in adult group, while in small group founds in first region. The highest average of fungiform papillae in both surface of both age groups are in the apex of tongue. The highest average of conical and circumvalate papillae in both age group (adult and young were on torus linguae. The histological study has been used the shape, diameter and the type of epithelium which covered the papillae in both groups. The filiform papillae are long fine projection beading
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NPP Siting in Western Part of Java Island Indonesia: Regional Analysis Stage
International Nuclear Information System (INIS)
Sastratenaya, A.S.; Yuliastuti
2011-01-01
Full text of publication follows: Considering that Banten and West Java Provinces are dense regions of industry, therefore they require a large amount of electricity. Nuclear power plant is one option to be considered to anticipate the future electricity demand. To support the program, it is needed to look for some potential locations through NPP siting. The siting should meet the requirement of safety, safety aspects of the natural external events, human induced external events, public and environmental safety. Site selection is performed in several stages, where each stage has specific assessment criteria. Siting is commenced with pre-survey activity to obtain several interest areas, the activity covers a wide area but the used data is very limited and only apply general criteria. The following activities after pre survey are site survey consisting of (1) regional analysis, (2) site screening, and (3) comparison and ranking stages. The objective of regional analysis is to obtain potential sites in the study area of 150 km radius from each interest area by using both general and specific criteria. The potential sites then screened to obtain selected candidate sites by using more detailed secondary data as well as survey activities such as geophysical investigation, a few of drilling, etc., within the radius of 50 km from each potential site. All the selected candidate sites are then compared and ranked to obtain preferred candidate site. Site evaluation is the next step to evaluate all site-specific parameter to obtain design basis parameters and as the basis for preparing site permit document. This paper presents the methodology and result of regional analysis stage. The objective of the activity is to obtain potential sites in the north coast of West Java and Banten Provinces by considering fourteen study aspects which could be categorize into safety related aspects, non-safety related aspect and public education. However, this paper only considers the safety
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Applying regional planning schemes in East Jutland, Denmark
DEFF Research Database (Denmark)
Grunfelder, Julien; Fertner, Christian
2010-01-01
landscapes. A common regional planning scheme is discussed for a while, but nothing is agreed on yet. Our objective is to apply three interesting spatial schemes to our case study region. The three planning schemes are well known for their simple and clear approach: The Fingerplan of Copenhagen urban region...... a development aligned along mass-transport corridors. In the Montpellier case, the planning scheme has the particularity of having a “sight inversion”. Thus, the landscape is presented as an integrated part of the reflection on regional development. In other words, it protects natural and agricultural areas......In the eastern part of Jutland, Denmark, a polycentric urban region is emerging. Besides Århus, the second biggest city of Denmark, several medium-sized cities are located in the area. The region is expected to experience further urbanisation which might result in urban sprawl and threaten valuable...
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DEFF Research Database (Denmark)
Jensen, Anne
Pricing of transport has been part of EU's common transport policy since this gained momentum in the early 1990s. Since then, it has been closely connected to the trans-European transport network (TEN-T) and to rising demands of efficient mobility systems at a local, regional and Community scale....... Development of pricing policies is contested at Community level and has taken place in a clash between different policy rationalities. Significantly though, the effects of the pricing policies are closely related to regional mobility systems, e.g. through financing large trans-border infrastructure projects...... and establishing common technical charging systems thus changing the conditions for regional mobility. This paper explores how policies of infrastructure pricing shape new ways of governing mobility which influences trans-border, regional policy-making. The key findings are that there is a tendency to include...
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International Nuclear Information System (INIS)
Moundy, Pierre-Jean
2011-01-01
After a recall of national objectives related to the share of renewable energies in final energy consumption, and of the defined content of a regional renewable energy scheme (determination of quantitative and qualitative objectives in terms of valorisation of the renewable and fatal energy potential within the region territory), and a recall of the different origins of biomass, the objective of this report was to compare potential energy usages with the available biomass resource (the present one and by 2020), in order to support the definition of regional objectives of development of biomass energy in the different geographical areas of the Languedoc-Roussillon region. Wood resource is first analysed. Assessments and perspectives are discussed for the different origins: (forests, sawmill by-products, wood scraps, green wastes), and regional consumptions of wood under various forms are also commented. The next part addresses agricultural biomass, its origins (crops, trimming residues, other agricultural activities, and agri-food industries), and the case of energy-oriented crops. The next part addresses biomass from domestic wastes (resource type and destruction, disposal or valorisation processes). The last part discusses objectives and development opportunities by 2020 for biomass and for heat, and in terms of the role of agricultural cooperatives and industries. Development levers and tools are briefly discussed
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Energy Technology Data Exchange (ETDEWEB)
Saeed, S.A.R. [King Saud University, Riyadh (Saudi Arabia). Dept. of Architecture and Building Science
1996-01-01
This study is an attempt to define thermal comfort requirements for Friday prayer during the hot season of Riyadh, Saudi Arabia. According to Islam, a Muslim should perform his prayers five times a day. The obligatory five prayers are Subuh prayer immediately before dawn, Thohor prayer in the afternoon, Assor prayer in late afternoon, Maghreb prayer immediately after sunset, and Ishaa prayer early evening. Generally, Muslims are encouraged to perform all five prayers in a mosque. Friday prayer that replaces Thohor prayer once a week, should take place in one of the main mosques of the neighbourhood. The mosque where Friday prayer could be performed is known as Friday mosque. Usually Friday prayer is attended by hundreds of worshippers and takes place in the afternoon. Since the summer of Riyadh is characterised by a very high temperature and a very low relative humidity, the indoor climate of the Friday mosque (Al-Masjed Al-Gamae) need a special study. This is the second part of a series of field investigations dealing with thermal comfort requirements in the hot-dry region of Saudi Arabia. (author)
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Capilla, Almudena; Schoffelen, Jan-Mathijs; Paterson, Gavin; Thut, Gregor; Gross, Joachim
2014-02-01
Modulations of occipito-parietal α-band (8-14 Hz) power that are opposite in direction (α-enhancement vs. α-suppression) and origin of generation (ipsilateral vs. contralateral to the locus of attention) are a robust correlate of anticipatory visuospatial attention. Yet, the neural generators of these α-band modulations, their interdependence across homotopic areas, and their respective contribution to subsequent perception remain unclear. To shed light on these questions, we employed magnetoencephalography, while human volunteers performed a spatially cued detection task. Replicating previous findings, we found α-power enhancement ipsilateral to the attended hemifield and contralateral α-suppression over occipito-parietal sensors. Source localization (beamforming) analysis showed that α-enhancement and suppression were generated in 2 distinct brain regions, located in the dorsal and ventral visual streams, respectively. Moreover, α-enhancement and suppression showed different dynamics and contribution to perception. In contrast to the initial and transient dorsal α-enhancement, α-suppression in ventro-lateral occipital cortex was sustained and influenced subsequent target detection. This anticipatory biasing of ventro-lateral extrastriate α-activity probably reflects increased receptivity in the brain region specialized in processing upcoming target features. Our results add to current models on the role of α-oscillations in attention orienting by showing that α-enhancement and suppression can be dissociated in time, space, and perceptual relevance.
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Regional cooperation in nuclear energy development
International Nuclear Information System (INIS)
Chung, K.; Muntzing, L.M.
1987-01-01
In November 1985, PBNCC (the Pacific Basin Nuclear Cooperation Committee) was formally established. Currently six Pacific Basin members have been participating in PBNCC: Canada, Japan, South Korea, Mexico, Taiwan of Chian, and the United States of America. The People's Republic of China has sent observes to the PBNCC meetings. The technical contents of PBWCC working groups are as follows: 1. Regional cooperative for pooled spare parts of nuclear power plants and inventory management; 2. Regional cooperation in nuclear training; 3. Regional cooperation on nuclear safety; 4. Regional cooperation in Codes and Standards; 5. Regional Cooperation in public acceptance; 6. Regional cooperation on radwaste management. (Liu)
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Brain stem origins of spinal projections in the lizard Tupinambis nigropunctatus.
Cruce, W L; Newman, D B
1981-05-10
In order to study brainstem origins of spinal projections, ten Tegu lizards (Tupinambis nigropunctatus) received complete or partial hemisections of the spinal cord at the first or second cervical segment. Their brains were processed for conventional Nissl staining. The sections were surveyed for the presence or absence of retrograde chromatolysis. Based on analysis and comparison of results from lesions in the various spinal cord funiculi, the following conclusions were reached: The interstitial nucleus projects ipsilaterally to the spinal cord via the medial longitudinal fasciculus, as does the middle reticular field of the metencephalon. The red nucleus and dorsal vagal motor nucleus both project contralaterally to the spinal cord via the dorsal part of the lateral funiculus. The superior reticular field in the rostral metencephalon and the ventrolateral vestibular nucleus project ipsilaterally to the spinal cord via the ventral funiculus. The dorsolateral metencephalic nucleus and the ventral part of the inferior reticular nucleus of the myelencephalon both project ipsilaterally to the spinal cord via the dorsal part of the lateral funiculus. Several brainstem nuclei in Tupinambis project bilaterally to the spinal cord. The ventrolateral metencephalic nucleus, for example, projects ipsilaterally to the cord via the medial longitudinal fasciculus and contralaterally via the dorsal part of the lateral funiculus. The dorsal part of the inferior reticular nucleus projects bilaterally to the spinal cord via the dorsal part of the lateral funiculus. The nucleus solitarius complex projects contralaterally via the dorsal part of the lateral funiculus but ipsilaterally via the middle of the lateral funiculus. The inferior raphe nucleus projects bilaterally to the spinal cord via the middle part of the lateral funiculus. These data suggest that supraspinal projections in reptiles, especially reticulospinal systems, are more highly differentiated than previously thought
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Leeuwen, van M.
2008-01-01
The idea has gained ground in recent years that, as conflicts in the countries of the Great Lakes Region are strongly interlinked, regional approaches are necessary to resolve them. This interest in regional dimensions of conflict and peacebuilding also gains currency in other parts of the world.
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Rowińska-Zakrzewska, Ewa; Korzeniewska-Koseła, Maria; Roszkowski-Śliż, Kazimierz
2014-01-01
influence transmission of tuberculosis. There is also the possibility that the differences in the epidemiological situation in various regions of Poland are caused by historical events. In the past the epidemiological situation of tuberculosis was much worse in the east of Europe than in the west. Just after the Second World War, according to the changes of the Polish territory, many Polish citizens (mainly ancestors of those from Group I) were displaced from the east to the west. In conclusion, the greater number of patients lost from observation, together with the higher density of population in the regions from Group I in comparison with those from Group II, seems to be partly responsible for the difference in the epidemiological situation in the two regions. It is also possible that some patients from Group I are more susceptible to infection and disease caused by Mycobacterium tuberculosis due to their ancestors, who lived in the east of Europe.
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Basal ganglia and cortical networks for sequential ordering and rhythm of complex movements
Directory of Open Access Journals (Sweden)
Jeffery G. Bednark
2015-07-01
Full Text Available Voluntary actions require the concurrent engagement and coordinated control of complex temporal (e.g. rhythm and ordinal motor processes. Using high-resolution functional magnetic resonance imaging (fMRI and multi-voxel pattern analysis (MVPA, we sought to determine the degree to which these complex motor processes are dissociable in basal ganglia and cortical networks. We employed three different finger-tapping tasks that differed in the demand on the sequential temporal rhythm or sequential ordering of submovements. Our results demonstrate that sequential rhythm and sequential order tasks were partially dissociable based on activation differences. The sequential rhythm task activated a widespread network centered around the SMA and basal-ganglia regions including the dorsomedial putamen and caudate nucleus, while the sequential order task preferentially activated a fronto-parietal network. There was also extensive overlap between sequential rhythm and sequential order tasks, with both tasks commonly activating bilateral premotor, supplementary motor, and superior/inferior parietal cortical regions, as well as regions of the caudate/putamen of the basal ganglia and the ventro-lateral thalamus. Importantly, within the cortical regions that were active for both complex movements, MVPA could accurately classify different patterns of activation for the sequential rhythm and sequential order tasks. In the basal ganglia, however, overlapping activation for the sequential rhythm and sequential order tasks, which was found in classic motor circuits of the putamen and ventro-lateral thalamus, could not be accurately differentiated by MVPA. Overall, our results highlight the convergent architecture of the motor system, where complex motor information that is spatially distributed in the cortex converges into a more compact representation in the basal ganglia.
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Directory of Open Access Journals (Sweden)
Churashev V. N.
2016-03-01
Full Text Available The objective analysis and forecasting of heat saving in Russia are very difficult now as the statistical reporting under energy carriers is focused generally on indicators of production of fuel and energy, but not on indicators of their consumption. According to experts the main losses of FER happen when burning fuel on thermal power plant and boiler rooms. One of the main reasons of high losses of energy at a stage of transformation of fuel to electric and thermal energy is use of obsolete technologies of generation. In article the emphasis is placed on the analysis of possibility of reduction of losses of FER due to realization of innovative power technologies. On the basis of economic-mathematical tools (model of regional energy industry; current and expected fuel and energy balances of the region the assessment of potential volume of reductions of losses of heat power on the example of the Kemerovo region is carried out.
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Energy Technology Data Exchange (ETDEWEB)
Ben Lasmar, R.; Guellala, R.; Zouhri, L.; Sarsar Naouali, B.; Garrach, M.; Inoubli, M.H.
2016-07-01
The present study concentrates on the interpretation of well logs and seismic reflection data in the JeffaraDahar region (Southeast part of Tunisia) for a better characterization of the Triassic aquifer, a potential target of water supply. Lithological columns and their corresponding well logs reveal that Sidi Stout, Kirchaou and Touareg. sandstones as well as Mekraneb and Rehach dolomites are the main reservoirs of the Triassic aquifer. Well log analysis highlights many permeable and fractured layers that could play an important role in the groundwater circulation. The interpreted seismic sections and the resulting isochrone maps show a tectonic influence on the Triassic aquifer geometry in the Jeffara-Dahar region. The normal faulting of E-W and NW-SE accidents created an aquifer compartmentalized by raised and tilted blocks. Seismic cross-sections reveal that this structure controls the depth of permeable formations and the circulation of groundwater. These results will be useful for rationalising the future hydrogeological research that will be undertaken in the Jeffara-Dahar area. (Author)
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CLIMATE CHANGE AND ORIENTAL SPRUCE (PICEA ORIENTALIS ECOSYSTEMS IN EASTERN BLACKSEA REGION OF TURKEY
Directory of Open Access Journals (Sweden)
Aydın Tüfekçioğlu
2008-04-01
Full Text Available Climate change has been getting more attention from scientific community recently. Eastern Black Sea Region of Turkey will get significant influences from the climate change according to regional climate model (RegCM3. Oriental spruce (Picea orientalis L. is an important tree species of Turkey and it only grows in the Eastern Black Sea Region of Turkey. With the increase in global warming, spruce forests started to have serious bark beetle problems. More than 200 000 trees died in the region recently due to bark beetle attack. We used existing literature related to oriental spruce and future climate of the region and field observations done in the different times to assess current status of the spruce stands. Future climate of the region has been predicted using RegCM3 regional climate model. Climate change could significantly influence distribution, diversity, structure and stability of the oriental spruce ecosystems. According to RegCM3 regional climate model, the temperatures will increase 2-4 °C in the region in the next century. Future climate scenarios predict 200-300 mm increases in precipitation in the eastern part of the region while the western part won't have any increase in precipitation in the next century. Temperature increases in the western part of the region can cause more stress on spruce trees and would probably increase bark beetle attacks. Also, fire could become an important threat in the western part of the region. It is possible to observe 400-800 m upward shift in the spruce belt in the western part. Treeline of spruce stands would probably move upward both in western and eastern part of the North-eastern Blacksea Region.
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International Nuclear Information System (INIS)
Kornmann, Francois; Guiran, Ghislaine; Sadoux, Emmanuel; Weill, Frederic; Benkhelifa, Fouzi
2008-01-01
After a presentation of study objectives and scope, a first report outlines the actuality of climate change, describes predicted climate changes for the PACA region in terms of warming and decrease of precipitations. Regional social-economic challenges and sector impacts are also briefly described. The second report presents the adopted climate simulation parameters, and discusses results obtained in terms of temperature and of precipitations by 2030, 2050 and 2080 for the whole Great South East region. The third part proposes sector sheets which contain discussions of effects of climate change on the water resource, on biodiversity, on forest, on agriculture, on human health, on tourism, on energy, on building and transports, on natural risks. The next document is based on the previous ones. It discusses and comments the outcome of the first phase, the present situation of the region in terms of territorial dynamics and effects of climate change, and indicators of climate change. It also draws lessons from the prospective study which resulted in three scenarios for which a strategic assessment is proposed
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DEFF Research Database (Denmark)
Jensen, Anne; Jespersen, Per Homann
2006-01-01
The corridor between Oslo and Berlin is by the politicians of the regional authorities in the Scandinavian part of the corridor seen a region with unique qualities and a large innovation and growth potential. In order to explore and develop this potential an In-terreg project has been launched...... this task by applying principles of participative planning and with action research methodology are involving stakeholders in the process of defining, developing and disseminating the idea of the Corridor of Innovation and Cooperation - COINCO....
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Anders, Silke; Eippert, Falk; Wiens, Stefan; Birbaumer, Niels; Lotze, Martin; Wildgruber, Dirk
2009-11-01
Affective neuroscience has been strongly influenced by the view that a 'feeling' is the perception of somatic changes and has consequently often neglected the neural mechanisms that underlie the integration of somatic and other information in affective experience. Here, we investigate affective processing by means of functional magnetic resonance imaging in nine cortically blind patients. In these patients, unilateral postgeniculate lesions prevent primary cortical visual processing in part of the visual field which, as a result, becomes subjectively blind. Residual subcortical processing of visual information, however, is assumed to occur in the entire visual field. As we have reported earlier, these patients show significant startle reflex potentiation when a threat-related visual stimulus is shown in their blind visual field. Critically, this was associated with an increase of brain activity in somatosensory-related areas, and an increase in experienced negative affect. Here, we investigated the patients' response when the visual stimulus was shown in the sighted visual field, that is, when it was visible and cortically processed. Despite the fact that startle reflex potentiation was similar in the blind and sighted visual field, patients reported significantly less negative affect during stimulation of the sighted visual field. In other words, when the visual stimulus was visible and received full cortical processing, the patients' phenomenal experience of affect did not closely reflect somatic changes. This decoupling of phenomenal affective experience and somatic changes was associated with an increase of activity in the left ventrolateral prefrontal cortex and a decrease of affect-related somatosensory activity. Moreover, patients who showed stronger left ventrolateral prefrontal cortex activity tended to show a stronger decrease of affect-related somatosensory activity. Our findings show that similar affective somatic changes can be associated with
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Complex Regional Pain Syndrome
Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. It may happen ... move the affected body part The cause of CRPS is unknown. There is no specific diagnostic test. ...
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Bibliography on Cold Regions Science and Technology. Volume 51, Part 1.
1997-12-01
interaction, Ice heat flux, Drift, Ice forecasting, Ice models, Computer- ized simulation 51-1008 Renovation techniques of ski areas. |Les tech...project was to determine the perfor- mance of the ground-coupled heat pump HVAC systems installed as part of the building renovation to Building 2189 at...power sup- ply for automatic recording systems. [Compor- tamiento de acumuladores como fuente de energia electrica para la alimentation de sistemas
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Directory of Open Access Journals (Sweden)
Mbabazi Pamela K
2010-07-01
Full Text Available Abstract Background The Kagera region of north western Tanzania has a rich culture of traditional medicine use and practices. The dynamic inter-ethnic interactions of different people from the surrounding countries constitute a rich reservoir of herbal based healing practices. This study, the second on an ongoing series, reports on the medicinal plant species used in Katoro ward, Bukoba District, and tries to use the literature to establish proof of the therapeutic claims. Methodology Ethnomedical information was collected using Semi-structured interviews in Kyamlaile and Kashaba villages of Katoro, and in roadside bushes on the way from Katoro to Bukoba through Kyaka. Data collected included the common/local names of the plants, parts used, the diseases treated, methods of preparation, dosage, frequency and duration of treatments. Information on toxicity and antidote were also collected. Literature was consulted to get corroborative information on similar ethnomedical claims and proven biological activities of the plants. Results Thirty three (33 plant species for treatement of 13 different disease categories were documented. The most frequently treated diseases were those categorized as specific diseases/conditions (23.8% of all remedies while eye diseases were the least treated using medicinal plants (1.5% of all remedies. Literature reports support 47% of the claims including proven anti-malarial, anti-microbial and anti-inflammatory activity or similar ethnomedical uses. Leaves were the most frequently used plant part (20 species followed by roots (13 species while making of decoctions, pounding, squeezing, making infusions, burning and grinding to powder were the most common methods used to prepare a majority of the therapies. Conclusion Therapeutic claims made on plants used in traditional medicine in Katoro ward of Bukoba district are well supported by literature, with 47% of the claims having already been reported. This study further
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Organization of ascending spinal projections in Caiman crocodilus.
Ebbesson, S O; Goodman, D C
1981-01-01
Ascending spinal projections in the caiman (Caiman crocodilus) were demonstrated with Nauta and Fink-Heimer methods following hemisections of the third spinal segment in a series of twelve animals. These results were compared with earlier data in the literature obtained from a turtle, a snake, and a lizard using the same experimental and histological procedures. The results show remarkable similarities considering that each species represents a different reptilian order with different evolutionary history and habitat. However, the caiman displays several important peculiarities. Although the dorsal funiculus of the caiman contains the largest number of ascending spinal projections of the four species examined, this funiculus has not differentiated into cuneate and gracile fasciculi as is the case in the tegu lizard. The ventro-lateral ascending spinal projections follow a fundamentally similar general morphologic pattern in the four species with only minor variations. The anatomical arrangement in the caiman and tegu lizard appears most similar in the high cervical and the medullary regions; however, this is not the case in midbrain and thalamic regions where considerably more extensive projections are seen in the caiman. In the caiman an extensive spinal connection to the ventro-lateral nucleus of the dorsal thalamus is present; this connection is reminiscent of the mammalian spinal projection to the ventro-basal complex. The caiman has in common with the other three reptilian species a small projection to another dorsal thalamic region that is apparently homologous to the mammalian intralaminar nuclei, which are the destination of the mammalian paleospinothalamic tract.
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ROMANIA FEATURES OF REGIONAL DEVELOPMENT IN THE EUROPEAN CONTEXT
Directory of Open Access Journals (Sweden)
BUȘAN GABRIELA
2016-12-01
Full Text Available Regional development is a new concept that aims to boost and diversify economic activities, stimulate private sector investment, contribute to reducing unemployment and lead to an improvement in living standards. Development and harmonious arrangement of the territory is an imperative of any civilized state for the welfare of all its citizens.Regionalization is a top-down process, which has as a starting point regional imbalances and regionalism is a bottom-up process of representing how the region perceives regional consciousness considered as a homogeneous territory by its residents and the community. European reality is that where there is regionalization regionalism was imposed because "the future of Europe must be built by a balance between Brussels, states and regions." Regionalization is in fact the result of trends in territorial organization in European countries today. However, we can speak of a "Europe of regions" where regions are public corporate body that answers the need for territoralisation certain policies. This paper aims to define the first part, the concepts of region and regionalization in order to subsequently provide procedural issues on regional development policy. At the same time, it will highlight the main aspects of economic development, taking into account the economic, social, cultural. The last part of the paper we summarize the effects of policies on regional development regions of our country, guiding us as socio-economic situation.
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Preliminary results of local earthquake tomography around Bali, Lombok, and Sumbawa regions
Energy Technology Data Exchange (ETDEWEB)
Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id; Puspito, Nanang T; Yudistira, Tedi [Global Geophysical Reserach Group, Faculty of Mining and Petroleum Engineering, Institute of Technology Bandung, JlGanesa 10, Bandung, 40132 (Indonesia); Kusnandar, Ridwan; Sakti, Artadi Pria [Meteorological, Climatological, and Geophysical Agency (MCGA) of Indonesian, Jakarta (Indonesia)
2015-04-24
Bali, Sumbawa, and Lombok regions are located in active tectonic influence by Indo-Australia plate subducts beneath Sunda plate in southern part and local back-arc thrust in northern part the region. Some active volcanoes also lie from eastern part of Java, Bali, Lombok and Sumbawa regions. Previous studies have conducted subsurface seismic velocity imaging using regional and global earthquake data around the region. In this study, we used P-arrival time from local earthquake networks compiled by MCGA, Indonesia within time periods of 2009 up to 2013 to determine seismic velocity structure and simultaneously hypocenter adjustment by applying seismic tomography inversion method. For the tomographic inversion procedure, we started from 1-D initial velocity structure. We evaluated the resolution of tomography inversion results through checkerboard test and calculating derivative weigh sum. The preliminary results of tomography inversion show fairly clearly high seismic velocity subducting Indo-Australian and low velocity anomaly around volcano regions. The relocated hypocenters seem to cluster around the local fault system such as back-arc thrust fault in northern part of the region and around local fault in Sumbawa regions. Our local earthquake tomography results demonstrated consistent with previous studies and improved the resolution. For future works, we will determine S-wave velocity structure using S-wave arrival time to enhance our understanding of geological processes and for much better interpretation.
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HUMAN POTENTIAL AS A STRATEGIC FACTOR OF REGIONAL DEVELOPMENT
Directory of Open Access Journals (Sweden)
A.M. Korobeynikov
2008-12-01
Full Text Available The article gives an insight of human potential as the strategic factor of regional development. The matter of human potential and its role in regional reproducing process is considered; regional intellectual potential as an integral part of human potential is analysed. The author outlines major directions of active social policy, aimed to develop regional human potential.
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Bibliography on Cold Regions Science and Technology. Volume 47, Part 1, 1993
1993-09-01
mountain mass exchange, and runoff, [Lednikovaia sistema Af- runoff with regard to the role of snow cover and gla- systems. (Auth.) ganistana...cold regions engineering. peratre contrast betwneen the continent and the ocean Tocs - Oil Pipelines and Civil Engineering in Arctic Climates. Mar
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Magnetic fusion energy. Part VI
International Nuclear Information System (INIS)
Anon.
1982-01-01
The first chapter of this part describes briefly the DOE policy for fusion energy. Subsequent chapters include: FY 1980 overview - activities of the Office of Fusion Energy; subactivity descriptions (confinement systems, development and technology, applied plasma physics, and reactor projects); field activities (DOE laboratories, educational institutions, nonprofit organizations, and commercial firms); commercialization; environmental implications; regional activities; and international programs
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Directory of Open Access Journals (Sweden)
Majid Mohammadhosseini
2017-03-01
Full Text Available This study aimed to assess the chemical compositions of essential oils (EOs extracted through microwave-assisted hydrodistillation from aerial parts of 11 Artemisia species growing wild in different regions in Northern, Eastern, Western, and Central parts of Iran. The EOs were subsequently analyzed via GC and GC-MS. The percentage yields of the EOs varied over the range of 0.21-0.50 (w/w%. On the basis of these characterizations and spectral assignments, natural compounds including camphor, 1,8-cineole, camphene, α-pinene, β-pinene, β-thujone, and sabinene were the most abundant and frequent constituents among all studied chemical profiles. Accordingly, oxygenated monoterpenes, monoterpene hydrocarbons, and non-terpene hydrocarbons were the dominant groups of natural compounds in the chemical profiles of 13, 4, and 2 samples, respectively. Moreover, five chemotypes were identified using statistical analyses: camphene, α-pinene and β-pinene; 1,8-cineole; camphore and 1,8-cineole; camphore and camphore and β-thujone.
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Regional utvikling og partnerskap
DEFF Research Database (Denmark)
Halkier, H.; Gjertsen, A.
2004-01-01
Since the beginning of the 1990s, Danish regional policy has changed dramatically. As of January 1991, all central government incentive schemes were terminated, and since then the main components of spatial economic policy have been a host of subnational initiatives and the European Structural...... in European matters as envisaged in the ?Europe of the Regions? slogan. The aim of this chapter is to examine the transformation of regional policy in Denmark from the perspective of political decentralization and Europeanization in order to establish to what extent recent changes have increased the capacity...... of Danish regions to pursue their own agendas with regard to economic development, and explore the organizational strategies pursued by varies tiers of government in this process of rapid and profound policy change. The text is divided into three parts. The following section provides a brief outline...
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Results of the IRIS UV Burst Survey, Part I: Active Regions Tracked Limb to Limb
Madsen, C. A.; DeLuca, E.
2017-12-01
We present results from the first phase of an effort to thoroughly characterize UV bursts within the Interface Region Imaging Spectrograph (IRIS) data catalogue. The observational signatures of these phenomena include dramatically intensified and broadened NUV/FUV emission line profiles with absorption features from cool metallic ions. These properties suggest that UV bursts originate from plasma at transition region temperatures (≥ 80,000 K) which is deeply embedded in the cool lower chromosphere ( 5,000 K). Rigorously characterizing the energetic and dynamical properties of UV bursts is crucial since they have considerable potential to heat active region chromospheres and could provide critical constraints for models of magnetic reconnection in these regions. The survey first focuses on IRIS observations of active regions tracked from limb to limb. All observations consist of large field-of-view raster scans of 320 or 400 steps each, which allow for widespread detection of many burst profiles at the expense of having limited short-term time evolution information. We detect bursts efficiently by applying a semi-automated single-Gaussian fitting technique to Si IV 1393.8 Å emission profiles that isolates the distinct burst population in a 4-D parameter space. The robust sample of NUV/FUV burst spectra allows for precise constraints of properties critical for modeling reconnection in the chromosphere, including outflow kinetic energy, density estimates from intensity ratios of Si IV 1402.8 Å and O IV 1401.2 Å emission lines, and coincident measures of emission in other wavelengths. We also track burst properties throughout the lifetimes of their host active regions, noting changes in detection rate and preferential location as the active regions evolve. Finally, the tracked active region observations provide a unique opportunity to investigate line-of-sight effects on observed UV burst spectral properties, particularly the strength of Ni II 1393.3 Å absorption
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Determinants of Skilled Birth Attendance in the Northern Parts of Ghana
Directory of Open Access Journals (Sweden)
Kwamena Sekyi Dickson
2017-01-01
Full Text Available Background. An integral part of the Sustainable Development Goal three is to ensure universal access to sexual and reproductive healthcare services which include skilled delivery by the year 2030. We examined the determinants of skilled delivery among women in the Northern part of Ghana. Methods. The paper made use of data from the Demographic and Health Survey. Women from the Northern part of Ghana were included in the analysis. Bivariate descriptive analyses coupled with binary logistic regression estimation technique were used to analyse the data. Results. Region of residence, age, household wealth, education, distance to a health facility, religion, parity, partner’s education, and getting money for treatment were identified as the determinants of skilled delivery. While the probability of having a skilled delivery was higher in the Upper East Region, it was lower in the Northern and Upper West Regions compared to the Brong Ahafo Region. Conclusion. Our findings call for more attention from the Ghana Health Service and the Ministry of Health in addressing the skilled delivery gaps among women particularly in the Northern and Upper West Regions in ensuring attainment of the Sustainable Development Goal target related to reproductive health care accessibility for all by the year 2030.
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The Malian Crisis and the Challenge of Regional Cooperation
Directory of Open Access Journals (Sweden)
Wolfram Lacher
2013-06-01
Full Text Available The weakness of regional security cooperation has been a key factor in the gradual destabilization of the Sahel-Sahara region over the past decade. While organized crime, extremist activity, and cross-border movements of arms and fighters have strengthened linkages among non-state actors in the region, state policies have failed to keep up. With the escalation of the crisis in Mali, West African states have adopted an approach diverging strongly from that of Mali’s North African neighbours. Western governments’ tendency to understand insecurity in the region through the notion of the Sahel has compounded the problem. Insecurity in the region, including criminal and extremist networks, is more Saharan than Sahelian in scope. North African states are part of the problem, and need to be part of the solution. A new framework for regional cooperation is needed – and while this can only be established on the initiative of regional states themselves, external actors need to adapt their policies to help such a framework emerge.
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Bibliography on Cold Regions Science and Technology. Volume 35, Part 2
1981-12-01
miMures [1480. p.»7-91, rus) 35-1088 Arbazov, \\.A. I sing liquid chlorides in wmtet on slippery loads (1480. p 1 I. 21, ■ us...3,-2*J I sing liquid chlondes in winter on slippery roads [ 1480. p, 11. Ryan, U L Safonova, T.A. ii...volumes, ins, 35-858 Problems of the Vulb. a cmieiit bibllographs , IISII. I»«p.rtls) 35-859 Open pit nulling in aistie regions Elm . S.S
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Astrocitary niches in human adult medulla oblongata.
Rusu, Mugurel Constantin; Dermengiu, Dan; Loreto, Carla; Motoc, Andrei Gheorghe Marius; Pop, Elena
2013-04-01
Astrocytes are considered as neuromodulators of the CNS. Whereas experimental studies on astrocitary functions are gaining importance, the anatomy of the astrocitary niches in the human CNS has been overlooked. The study was performed on the brainstem of 10 adult cadavers. We aimed to determine astrocitary niches in the human medulla oblongata using immunohistochemical labeling with vimentin and also CD34 immunostaining to accurately diagnose associated microvessels. Niches rich in astrocytes were identified as follows: (a) the superficial layer of astrocytes, ventral and ventrolateral, in the rostral medulla oblongata; (b) the median raphe; (c) medullary nuclei: arcuate nucleus, area postrema, nucleus of the solitary tract; (d) the subependymal zone (SEZ, caudal medulla) and subventricular zone (SVZ, rostral medulla). Astrocytes were scarce in the ventrolateral medulla, and mostly present within the pyramidal tract and the olivary nucleus. Apart from the SEZ and SVZ, the brainstem niches of astrocytes mostly overlap those regions known to perform roles as central respiratory chemoreceptors. The astrocytes of the SEZ and SVZ, which are known as stem cell niches, are related to an increased microvascular density. Copyright © 2012 Elsevier GmbH. All rights reserved.
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Neural Computations Mediating One-Shot Learning in the Human Brain
Lee, Sang Wan; O’Doherty, John P.; Shimojo, Shinsuke
2015-01-01
Incremental learning, in which new knowledge is acquired gradually through trial and error, can be distinguished from one-shot learning, in which the brain learns rapidly from only a single pairing of a stimulus and a consequence. Very little is known about how the brain transitions between these two fundamentally different forms of learning. Here we test a computational hypothesis that uncertainty about the causal relationship between a stimulus and an outcome induces rapid changes in the rate of learning, which in turn mediates the transition between incremental and one-shot learning. By using a novel behavioral task in combination with functional magnetic resonance imaging (fMRI) data from human volunteers, we found evidence implicating the ventrolateral prefrontal cortex and hippocampus in this process. The hippocampus was selectively “switched” on when one-shot learning was predicted to occur, while the ventrolateral prefrontal cortex was found to encode uncertainty about the causal association, exhibiting increased coupling with the hippocampus for high-learning rates, suggesting this region may act as a “switch,” turning on and off one-shot learning as required. PMID:25919291
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International Nuclear Information System (INIS)
Lundsager, P.; Ahm, P.; Madsen, B.; Krogsgaard, P.
1993-07-01
Arctic or semi-arctic regions are often endowed with wind resources adequate for a viable production of electricity from the wind. Only limited efforts have so far been spent to introduce and to demonstrate the obvious synergy of combining wind power technology with the problems and needs of electricity generation in Arctic regions. Several factors have created a gap preventing the wind power technology carrying its full role in this context, including a certain lack of familiarity with the technology on the part of the end-users, the local utilities and communities, and a lack of commonly agreed techniques to adapt the same technology for Arctic applications on the part of the manufacturers. This report is part of a project that intends to contribute to bridging this gap. The preliminary results of a survey conducted by the project are included in this report, which is a working document for an international seminar held on June 3-4, 1993, at Risoe National Laboratory, Denmark. Following the seminar a final report will be published. It is intended that the final report will serve as a basis for a sustained, international effort to develop the wind power potential of the Arctic and semi-arctic regions. The project is carried out by a project group formed by Risoe, PA Energy and BTM Consult. The project is sponsored by the Danish Energy Agency of the Danish Ministry of Energy through grant no. ENS-51171/93-0008. (au)
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Dumbbell meningioma of the cervico-clavicular region.
Hlavka, V; Miklić, P; Besenski, N; Miklić, D; Franz, G
1991-01-01
The authors are reporting on a case of a 55-year-old man with an epidural meningioma in the region from the C VII. to the Th I. segment. The tumor encircled this region, and to the front and right involved the channels through which pass the C VI, C VII. and C VIII. roots. Subdurally, no tumoral mass was found. Another part of this tumor, of the same histological architecture as the epidural cervicospinal part was found in the supraclavicular region to the right, closely connected to the arteries and nerves of this region. The authors discuss the possibility of the tumoral occurrence at this site, primarily taking into account the origin of this tumor from the cells of the outer surface of the arachnoidea, i.e. cap cells which can invade the dura, with later separation from the main arachnoidal layer. The other possibility of such dumbbell meningioma occurring at the outgoing openings of the neural paths from the spinal channel should be looked for in the remnants of the arachnoidal cells in the region of the outgoing openings. In the paper are also discussed and correlated clinico-pathological, CT and angiographic findings.
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A real-time standard parts inspection based on deep learning
Xu, Kuan; Li, XuDong; Jiang, Hongzhi; Zhao, Huijie
2017-10-01
Since standard parts are necessary components in mechanical structure like bogie and connector. These mechanical structures will be shattered or loosen if standard parts are lost. So real-time standard parts inspection systems are essential to guarantee their safety. Researchers would like to take inspection systems based on deep learning because it works well in image with complex backgrounds which is common in standard parts inspection situation. A typical inspection detection system contains two basic components: feature extractors and object classifiers. For the object classifier, Region Proposal Network (RPN) is one of the most essential architectures in most state-of-art object detection systems. However, in the basic RPN architecture, the proposals of Region of Interest (ROI) have fixed sizes (9 anchors for each pixel), they are effective but they waste much computing resources and time. In standard parts detection situations, standard parts have given size, thus we can manually choose sizes of anchors based on the ground-truths through machine learning. The experiments prove that we could use 2 anchors to achieve almost the same accuracy and recall rate. Basically, our standard parts detection system could reach 15fps on NVIDIA GTX1080 (GPU), while achieving detection accuracy 90.01% mAP.
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EPA Region 1 Environmentally Sensitive Areas
U.S. Environmental Protection Agency — This coverage represents polygon equivalents of environmentally sensitive areas (ESA) in EPA Region I. ESAs were developed as part of an EPA headquarters initiative...
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MR diagnosis of infantile teratoma in sacrococcygeal region
International Nuclear Information System (INIS)
Xu Jianchang; Gao Zhiqin; Lou Jianghua
2009-01-01
Objective: To discuss the MR manifestations of infantile teratoma in sacrococcygeal region and to evaluate the diagnostic value of MR. Methods: Retrospective analysis was adopted on the MR results of 15 affected infants. Results: The tumors in 2 cases located in hip, which is mainly cystic, circular or ellipse shaped with septum and fat signal can be seen. The wall and septum of the cysts can be reinforced in contrast enhanced imaging. The tumor in 1 case located total in pelvic cavity, presenting cystic and solitary mixed signal. The solitary part, cystic wall and septum can be obviously unequally reinforced in contrast enhanced imaging. In the rest 12 cases, the most parts of tumors located in pelvic cavity and small parts in hip presenting mainly cystic and partly solitary mixed signal. The solitary part, cystic wall and septum can be reinforced in contrast enhanced imaging. Conclusion: MR can accurately display the location and shape of teratoma in sacrococcygeal region and is contribute to diagnose and differentiate benign or malignant lesion, in order to help clinician to choose operation method. (authors)
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Neural circuits in auditory and audiovisual memory.
Plakke, B; Romanski, L M
2016-06-01
Working memory is the ability to employ recently seen or heard stimuli and apply them to changing cognitive context. Although much is known about language processing and visual working memory, the neurobiological basis of auditory working memory is less clear. Historically, part of the problem has been the difficulty in obtaining a robust animal model to study auditory short-term memory. In recent years there has been neurophysiological and lesion studies indicating a cortical network involving both temporal and frontal cortices. Studies specifically targeting the role of the prefrontal cortex (PFC) in auditory working memory have suggested that dorsal and ventral prefrontal regions perform different roles during the processing of auditory mnemonic information, with the dorsolateral PFC performing similar functions for both auditory and visual working memory. In contrast, the ventrolateral PFC (VLPFC), which contains cells that respond robustly to auditory stimuli and that process both face and vocal stimuli may be an essential locus for both auditory and audiovisual working memory. These findings suggest a critical role for the VLPFC in the processing, integrating, and retaining of communication information. This article is part of a Special Issue entitled SI: Auditory working memory. Copyright © 2015 Elsevier B.V. All rights reserved.
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Directory of Open Access Journals (Sweden)
Manish S Dalwani
Full Text Available Structural neuroimaging studies have demonstrated lower regional gray matter volume in adolescents with severe substance and conduct problems. These research studies, including ours, have generally focused on male-only or mixed-sex samples of adolescents with conduct and/or substance problems. Here we compare gray matter volume between female adolescents with severe substance and conduct problems and female healthy controls of similar ages.Female adolescents with severe substance and conduct problems will show significantly less gray matter volume in frontal regions critical to inhibition (i.e. dorsolateral prefrontal cortex and ventrolateral prefrontal cortex, conflict processing (i.e., anterior cingulate, valuation of expected outcomes (i.e., medial orbitofrontal cortex and the dopamine reward system (i.e. striatum.We conducted whole-brain voxel-based morphometric comparison of structural MR images of 22 patients (14-18 years with severe substance and conduct problems and 21 controls of similar age using statistical parametric mapping (SPM and voxel-based morphometric (VBM8 toolbox. We tested group differences in regional gray matter volume with analyses of covariance, adjusting for age and IQ at p<0.05, corrected for multiple comparisons at whole-brain cluster-level threshold.Female adolescents with severe substance and conduct problems compared to controls showed significantly less gray matter volume in right dorsolateral prefrontal cortex, left ventrolateral prefrontal cortex, medial orbitofrontal cortex, anterior cingulate, bilateral somatosensory cortex, left supramarginal gyrus, and bilateral angular gyrus. Considering the entire brain, patients had 9.5% less overall gray matter volume compared to controls.Female adolescents with severe substance and conduct problems in comparison to similarly aged female healthy controls showed substantially lower gray matter volume in brain regions involved in inhibition, conflict processing, valuation
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GRAVITY VARIATIONS AND RECENT GEODYNAMICS OF THE SOUTH-WESTERN PART OF THE BAIKAL REGION
Directory of Open Access Journals (Sweden)
V. Yu. Timofeev
2013-01-01
Full Text Available Modern methods for determination of gravity values make it possible to obtain measurements with the accuracy up to 10–9 from g0 of the normal value (up to 1 microgal = 10 m/sec2. While all the systematic and periodic effects are excluded, a question is raised about stability of the gravity field of the Earth over time. Changes of the altitude (the Earth’s radius with time can be estimated with an accuracy of 0.1 mm by modern space geodetic techniques, such as VLBI method. Our experiments for evaluation of stability of the gravity values over the past decades are based on the data obtained by Russian and foreign observatories using absolute ballistic laser gravimeters. The results put a limit of 10–10 per year to changes of the Earth’s radius. These estimations can be useful for testing hypotheses in tectonics.Measurements of non-tidal variations of gravity (Δg, which were obtained from 1992 to 2012 at the Talaya seismic station (located in the south-western part of the Baikal region, are interpreted together with GPS observation data. At the Talaya seismic station, the linear component of gravity variations corresponds to changes in the elevation of this site. The correlation coefficient is close to the normal value of the vertical gradient of gravity. At this site, coseismic gravity variations at the time of the Kultuk earthquake (27 August 2008, Mw=6.3 were caused by a combined effect of the change of the site’s elevation and deformation of the crust. Our estimations of the coseismic effects are consistent with results obtained by modeling based on the available seismic data.
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Early development of the circumferential axonal pathway in mouse and chick spinal cord.
Holley, J A
1982-03-10
The early development of the circumferential axonal pathway in the brachial and lumbar spinal cord of mouse and chick embryos was studied by scanning and transmission electron microscopy. The cellular processes which comprise this pathway grow in the transverse plane and along the lateral margin of the marginal zone (i.e., circumferentially oriented), as typified by the early embryonic commissural axons. The first formative event observed was in the ventrolateral margin of the primitive spinal cord ventricular zone. Cellular processes were found near the external limiting membrane that appeared to grow a variable distance either dorsally or ventrally. Later in development, presumptive motor column neurons migrated into the ventrolateral region, distal to these early circumferentially oriented processes. Concurrently, other circumferentially oriented perikarya and processes appeared along the dorsolateral margin. Due to their aligned sites of origin and parallel growth, the circumferential processes formed a more or less continuous line or pathway, which in about 10% of the scanned specimens could be followed along the entire lateral margin of the embryonic spinal cord. Several specimens later in development had two sets of aligned circumferential processes in the ventral region. Large numbers of circumferential axons were then found to follow the preformed pathway by fasciculation, after the primitive motor column had become established. Since the earliest circumferential processes appeared to differentiate into axons and were found nearly 24 hours prior to growth of most circumferential axons, their role in guidance as pioneering axons was suggested.
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Levels of integration in cognitive control and sequence processing in the prefrontal cortex.
Bahlmann, Jörg; Korb, Franziska M; Gratton, Caterina; Friederici, Angela D
2012-01-01
Cognitive control is necessary to flexibly act in changing environments. Sequence processing is needed in language comprehension to build the syntactic structure in sentences. Functional imaging studies suggest that sequence processing engages the left ventrolateral prefrontal cortex (PFC). In contrast, cognitive control processes additionally recruit bilateral rostral lateral PFC regions. The present study aimed to investigate these two types of processes in one experimental paradigm. Sequence processing was manipulated using two different sequencing rules varying in complexity. Cognitive control was varied with different cue-sets that determined the choice of a sequencing rule. Univariate analyses revealed distinct PFC regions for the two types of processing (i.e. sequence processing: left ventrolateral PFC and cognitive control processing: bilateral dorsolateral and rostral PFC). Moreover, in a common brain network (including left lateral PFC and intraparietal sulcus) no interaction between sequence and cognitive control processing was observed. In contrast, a multivariate pattern analysis revealed an interaction of sequence and cognitive control processing, such that voxels in left lateral PFC and parietal cortex showed different tuning functions for tasks involving different sequencing and cognitive control demands. These results suggest that the difference between the process of rule selection (i.e. cognitive control) and the process of rule-based sequencing (i.e. sequence processing) find their neuronal underpinnings in distinct activation patterns in lateral PFC. Moreover, the combination of rule selection and rule sequencing can shape the response of neurons in lateral PFC and parietal cortex.
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10 CFR Appendix B to Part 600 - Audit Report Distributees
2010-01-01
... 10 Energy 4 2010-01-01 2010-01-01 false Audit Report Distributees B Appendix B to Part 600 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS FINANCIAL ASSISTANCE RULES Pt. 600, App. B Appendix B to Part 600—Audit Report Distributees Distributee: Manager, Eastern Region, Office of Inspector...
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25 CFR 170.5 - What definitions apply to this part?
2010-04-01
... travel. Real Property means any interest in land together with the improvements, structures, and fixtures... means calendar days, except where the last day of any time period specified in this part falls on a... facilities that offer a significant alternative to regional highway travel. (“Regional transportation needs...
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International Nuclear Information System (INIS)
2012-08-01
This document first presents the regional wind energy scheme (SRE) as a framework for ground-based wind energy development, and as the wind energy component of the regional climate air energy scheme (SRCAE), briefly presents the elaboration approach, and indicates the legal scope of this scheme. The next part outlines the high rate development of wind energy in the Pays-de-la-Loire region. The third part reports the identification, analysis and assessment of areas of interest for the development of wind energy. Finally, the objective of this development by 2020 is estimated
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International Nuclear Information System (INIS)
Ohtani, S.; Kokubun, S.; Nakamura, R.; Elphic, R.C.; Russell, C.T.; Baker, D.N.
1990-01-01
The development of the substorm-associated current system in the near-tail region is examined in the light of both experiment and theory. First, the March 28, 1979, event is examined intensively by using ground magnetometer data and satellite magnetic field and energetic particle data. The comparison of field-aligned current signatures at geosynchronous altitude and in the near-tail region indicates that the development of the region 1 system is not merely the enhancement in current intensity of the pre-existing system. This finding is consistent with the so-called current wedge model, in which the tail current is converted into a pair of field-aligned currents with the region 1 polarity at substorm onsets. Detailed inspection, however, suggests that the region 2 system is as important as the region 1 system. Statistical properties of the azimuthal magnetic component at synchronous orbit indicate that the deviation during disturbed periods is larger than expected from the enhancement of the region 1 current. These individual and statistical studies suggest that the region 2 system tends to develop in the synchronous region and that the coupling between the region 1 and the region 2 systems is important. The current closure in the magnetosphere is discussed from a viewpoint of the macroscopic behavior of plasma. It is suggested that the dawnside and the duskside region 2 currents are closed in the magnetosphere by the curvature current during the growth phase and by the magnetic gradient current during the expansion phase. The field-aligned currents of the region 1 and the region 2 systems are closed in the ionosphere by the Pedersen current. Consequently, the energy is dissipated as the Joule heating and this energy must be supplied from the magnetosphere. Therefore, the counter part of the Pedersen current, which closes the region 1 and the region 2 currents in magnetosphere, must be the dynamo current
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Minamoto, Takehiro; Osaka, Mariko; Yaoi, Ken; Osaka, Naoyuki
2014-01-01
Different people make different responses when they face a frustrating situation: some punish others (extrapunitive), while others punish themselves (intropunitive). Few studies have investigated the neural structures that differentiate extrapunitive and intropunitive individuals. The present fMRI study explored these neural structures using two different frustrating situations: an ego-blocking situation which blocks a desire or goal, and a superego-blocking situation which blocks self-esteem. In the ego-blocking condition, the extrapunitive group (n = 9) showed greater activation in the bilateral ventrolateral prefrontal cortex, indicating that these individuals prefer emotional processing. On the other hand, the intropunitive group (n = 9) showed greater activation in the left dorsolateral prefrontal cortex, possibly reflecting an effortful control for anger reduction. Such patterns were not observed in the superego-blocking condition. These results indicate that the prefrontal cortex is the source of individual differences in aggression direction in the ego-blocking situation.
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Crustal structure and tectonic model of the Arctic region
DEFF Research Database (Denmark)
Petrov, Oleg; Morozov, Andrey; Shokalsky, Sergey
2016-01-01
We present a new model of the crustal and tectonic structure of the Arctic region north of 60° N latitude, constrained as a part of the international Atlas of Geological Maps of the Circumpolar Arctic under the aegis of the Commission for the Geological Map of the World. The region is largely...... formed by (i) Archean-Paleoproterozoic shields and platforms, (ii) orogenic belts of the Neoproterozoic to the Late Mesozoic ages overlain by platform and basin sediments, (iii) Cenozoic rift structures formed in part as a consequence of seafloor spreading in the North East Atlantic Ocean...... and thickness of the sedimentary cover and presents tectonic regionalization based on 18 major crustal types (oceanic, transitional, and continental) recognized in the Arctic. A 7600. km-long crustal geotransect across the region illustrates the details of its crustal and tectonic structure. We discuss...
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Near-surface wind pattern in regional climate projections over the broader Adriatic region
Belušić, Andreina; Telišman Prtenjak, Maja; Güttler, Ivan; Ban, Nikolina; Leutwyler, David; Schär, Christoph
2017-04-01
The Adriatic region is characterized by the complex coastline, strong topographic gradients and specific wind regimes. This represents excellent test area for the latest generation of the regional climate models (RCMs) applied over the European domain. The most famous wind along the Adriatic coast is bora, which due to its strength, has a strong impact on all types of human activities in the Adriatic region. The typical bora wind is a severe gusty downslope flow perpendicular to the mountains. Besides bora, in the Adriatic region, typical winds are sirocco (mostly during the wintertime) and sea/land breezes (dominantly in the warm part of the year) as a part of the regional Mediterranean wind system. Thus, it is substantial to determine future changes in the wind filed characteristics (e.g., changes in strength and frequencies). The first step was the evaluation of a suite of ten EURO- and MED-CORDEX models (at 50 km and 12.5 km resolution), and two additional high resolution models from the Swiss Federal Institute of Technology in Zürich (ETHZ, at 12.5 km and 2.2. km resolution) in the present climate. These results provided a basis for the next step where wind field features, in an ensemble of RCMs forced by global climate models (GCMs) in historical and future runs are examined. Our aim is to determine the influence of the particular combination of RCMs and GCMs, horizontal resolution and emission scenario on the future changes in the near-surface wind field. The analysis reveals strong sensitivity of the simulated wind flow and its statistics to both season and location analyzed, to the horizontal resolution of the RCM and on the choice of the particular GCM that provides boundary conditions.
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Mayer, Jutta S; Roebroeck, Alard; Maurer, Konrad; Linden, David E J
2010-01-01
The idea of an organized mode of brain function that is present as default state and suspended during goal-directed behaviors has recently gained much interest in the study of human brain function. The default mode hypothesis is based on the repeated observation that certain brain areas show task-induced deactivations across a wide range of cognitive tasks. In this event-related functional resonance imaging study we tested the default mode hypothesis by comparing common and selective patterns of BOLD deactivation in response to the demands on visual attention and working memory (WM) that were independently modulated within one task. The results revealed task-induced deactivations within regions of the default mode network (DMN) with a segregation of areas that were additively deactivated by an increase in the demands on both attention and WM, and areas that were selectively deactivated by either high attentional demand or WM load. Attention-selective deactivations appeared in the left ventrolateral and medial prefrontal cortex and the left lateral temporal cortex. Conversely, WM-selective deactivations were found predominantly in the right hemisphere including the medial-parietal, the lateral temporo-parietal, and the medial prefrontal cortex. Moreover, during WM encoding deactivated regions showed task-specific functional connectivity. These findings demonstrate that task-induced deactivations within parts of the DMN depend on the specific characteristics of the attention and WM components of the task. The DMN can thus be subdivided into a set of brain regions that deactivate indiscriminately in response to cognitive demand ("the core DMN") and a part whose deactivation depends on the specific task. 2009 Wiley-Liss, Inc.
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Administrative competence of regions in connection with the establishment of power plants
International Nuclear Information System (INIS)
Poidomani, C.
1980-03-01
This paper which is divided into two parts, analyses the concept of competence underlying the regulations concerning the transfer of certain state duties to the regions. The author considers that this concept does not seem adaptable to the various functions the regions are required to discharge in the energy field. A description follows of the technical and administrative authority given to the regions in the licensing process for power-producing plants. The second part of the paper deals with recent regulations concerning energy conservation and development of alternative energy sources, in the context of regional competence. (NEA) [fr
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Directory of Open Access Journals (Sweden)
Ervīns Lukševičs
2018-01-01
Full Text Available The results of the detailed sedimentological study and bed-by-bed collecting of fossils from the Borschovo section exposing the upper Givetian–lower Frasnian boundary beds are discussed. The succession consists of sandstones alternating with argillaceous and clayey packages that contain vertebrate and plant remains in the upper part. The grain size, sedimentary structures and cross-bed orientation considerably differ in the Oredezh Beds and the Staritsa Beds. Fine- to coarse-grained cross-stratified sandstones of the Oredezh Beds most probably are fluvial deposits, whereas the sandstones of the Staritsa Beds yielding tidal structures that show variable directions of the cross-bedding were accumulated in a tidally influenced or even tidally dominated environment. The Oredezh Beds in the study area lack fossils; however, sedimentary features allow correlation with the Sietiņi Formation corresponding to the lower part of the Gauja Regional Stage. The age of the Staritsa Beds is defined based on the distribution of vertebrate taxa as corresponding to the Amata Regional Stage. Probably, the deposits from the Borschovo locality represent the most complete section of the Staritsa Beds, including its lowermost part. Rather good preservation of some thin and fragile fish bones, buried together with large-sized quartz grains, and wide taxonomical diversity, are characteristic of the Borschovo locality, which is not common for the vertebrate localities of the Main Devonian Field corresponding to the Amata Regional Stage.
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Benson, L.V.
2011-01-01
Maize is the New World's preeminent grain crop and it provided the economic basis for human culture in many regions within the Americas. To flourish, maize needs water, sunlight (heat), and nutrients (e. g., nitrogen). In this paper, climate and soil chemistry data are used to evaluate the potential for dryland (rainon-field) agriculture in the semiarid southeastern Colorado Plateau and Rio Grande regions. Processes that impact maize agriculture such as nitrogen mineralization, infiltration of precipitation, bare soil evaporation, and transpiration are discussed and evaluated. Most of the study area, excepting high-elevation regions, receives sufficient solar radiation to grow maize. The salinities of subsurface soils in the central San Juan Basin are very high and their nitrogen concentrations are very low. In addition, soils of the central San Juan Basin are characterized by pH values that exceed 8.0, which limit the availability of both nitrogen and phosphorous. In general, the San Juan Basin, including Chaco Canyon, is the least promising part of the study area in terms of dryland farming. Calculations of field life, using values of organic nitrogen for the upper 50 cm of soil in the study area, indicate that most of the study area could not support a 10-bushel/acre crop of maize. The concepts, methods, and calculations used to quantify maize productivity in this study are applicable to maize cultivation in other environmental settings across the Americas. ?? 2010 US Government.
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Brand as a significant element of the regional development strategy at the example of Devin
Directory of Open Access Journals (Sweden)
Goranova Penka
2015-01-01
Full Text Available The idea of (regional branding is an important issue in modern business environment. Theoretical studies in this area are few, compared to research papers that have been dedicated to traditional brands and branding. A practical research on brand as an important element of regional development strategy can thus provide a series of useful information that marketers can use in their marketing strategies and in branding process in particular. The aim of this article is an assessment of regional branding, at the example of Devin. The article consists of two main parts. The first part focuses on defining regional branding and discussing why regional branding is important. The second part analyses the brand Devin and shows how a regional brand can evolve from a concept to reality.
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The regional control of the canadian energy production
International Nuclear Information System (INIS)
Petitlaurent, S.; Sarrazin, J.
2004-12-01
This document provides information and presents data on the energy situation in many regions of Canada. The first part deals with the petroleum and the bitumen shales of Alberta (reserves, exploitation and production, environmental impacts), the second part discusses with the hydroelectricity choice of Quebec and the 2004 crisis. The nuclear situation of Ontario is presented in the third part (nuclear park, programs, uranium reserves, research and development on Candu reactors), while the fourth part deals with the renewable energies (wind power and biomass). The canadian situation facing the Kyoto protocol is discussed in the last part. (A.L.B.)
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Regionalization of the Pohorsko Podravje - some dilemmas
Directory of Open Access Journals (Sweden)
Ivan Gams
1991-12-01
Full Text Available Dilemmas of the regionalisation of the mountainous part of the basin of the Drava( Pohorsko Podravje. In the planned new geographical monograph of Slovenia, also the Pohorsko Podravje shoud be represented in frame of mezoregions as a complex of actual regional factors, and in frame of submacroregions the genesis of the regional elements mostlv.
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Directory of Open Access Journals (Sweden)
Bernhard Mueller
2000-01-01
Full Text Available For many decades of the 20th century particular cities and towns were understood as integral parts of national and international urban systems. For many years the theory on central places and hierarchy of central places, first developed by Christaller and amended by Loesch, had a decisive influence on spatial research and regional development policies with guiding principles for urbanisation and the development of settlement patterns. However it is becoming ever more evident, that the planned effects of concepts for harmonising intra- and inter-regional differences were not reached. Moreover, inter-regional competition between neighbouring municipalities, as well as modern life styles and residential choices have caused the emergence of new settlement structures with dispersed spatial patterns and string functional ties. It is also true, that urban networking isn’t an easy task and that it inherently carries numerous obstacles.
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DETERMINANTS OF FDI INFLOWS: THE CASE OF RUSSIAN REGIONS
Directory of Open Access Journals (Sweden)
Oleg Svyatoslavovich Mariev
2016-12-01
Full Text Available This paper empirically analyses the determinants of foreign direct investment inflows into the Russian regions. This problem has become highly relevant for the necessary modernization of the Russian economy after the recent economic slowdown and sharp decrease in budget revenues. The authors model foreign direct investment flows with the use of the gravity approach according to which investment flows are positively correlated with the size of the investor’s country as well as the size of the recipient region and are negatively correlated with the distance between investor and recipient. The empirical analysis is based on a constructed database consisting of the foreign direct investment flows from 179 investor countries into 78 Russian regions for the period 2006–2013. The authors apply the Poisson Pseudo Maximum Likelihood method and identify the following factors determining foreign direct investment inflows into the Russian economy: the gross domestic product of the investor’s country, the gross domestic product per capita in the recipient region, the distance from the investor to Moscow, the openness of the region, the economic situation in the region, the innovative capacity of the region and the foreign direct investment of the previous period. Interestingly, the distance from the recipient region to Moscow matters for the regions in the western part of Russia (relatively close to Moscow but is not significant for the regions in the eastern part (remote regions.
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THEORETICAL ASPECTS OF INFORMATIONAL SERVICES REGIONAL MARKET EFFECTIVE DEVELOPMENT
Directory of Open Access Journals (Sweden)
I.N. Korabejnikov
2008-12-01
Full Text Available The peculiarities and priorities of the informational services regional market formation as a part of network model of the economic development are described in this article. The authors present the classification of the factors which have an influence on the effectiveness of the informational services regional market development. Theoretical aspects of the informational services regional market effective development are shown.
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Yamada, Kentaro; Narimatsu, Yuri; Ono, Yumie; Sasaguri, Ken-Ichi; Onozuka, Minoru; Kawata, Toshitsugu; Yamamoto, Toshiharu
2015-07-10
We investigated the effects of chewing under immobilization stress on the periaqueductal gray (PAG) matter using phosphorylated extracellular signal-regulated kinase (pERK) as a marker of responding cells. Immobilization stress increased pERK-immunoreactive cells in the PAG. Among four subdivisions of the PAG, the increase of immunoreactive cells was remarkable in the dorsolateral and ventrolateral subdivisions. However, increase of pERK-immunoreactive cells by the immobilization stress was not so evident in the dorsomedial and lateral subdivisions. The chewing under immobilization stress prevented the stress-induced increase of pERK-immunoreactive cells in the dorsolateral and ventrolateral subdivisions with statistical significances (p<0.05). Again, chewing effects on pERK-immunoreactive cells were not visible in the dorsomedial and lateral subdivisions. These results suggest that the chewing alleviates the PAG (dorsolateral and ventrolateral subdivisions) responses to stress. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
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The Impact of Regional Disparities on Economic Growth
Directory of Open Access Journals (Sweden)
Henryk Gurgul
2011-01-01
Full Text Available The authors investigated how economic growth affects the disparity in the distribution of regional income in Poland and vice versa. The research was based on annual data covering the period 2000-2009. In general, the research was divided into two main parts. First, the authors examined the evolution of the level of spatial inequalities in income in Poland over the last decade using the concepts of sigma and beta convergence. Next the nature of causal dependences was investigated between this inequality and economic growth. It was found that Polish regions did not converge with respect to the distribution of income as total GDP grew. The second part of the research provided evidence to claim that this inequality caused growth. Moreover, the evidence was also found that growth affected regional inequality. Finally, the authors noticed that the effects of both these factors were positive. The results suggest that as a consequence of rapid economic growth, some regions in Poland seized new opportunities, while less developed regions were unable to keep up with the challenging requirements of a decade of fast economic growth. (original abstract
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Bontje, M.A.; Pethe, H.A.A.; Rühmann, P.
2008-01-01
The report brings together the results of a survey of creative knowledge workers in the Amsterdam region. How do creative knowledge workers judge the living situation and what activities do they pursue in the different parts of the region? How satisfied are creative knowledge workers with their
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High tech in the Öresund region
DEFF Research Database (Denmark)
Hansen, Povl Adler; Serin, Göran Folke
This book discusses the development conditions in the high tech sector for both high tech manufacturing and services. A central issue in the book is the differences in externalities which exist between various industries in the high tech sector. In this connection the confusion of externalities...... related to different parts of the high tech sector will be addressed. The location of the high tech sector in the Öresund region will be analysed and the region will also be related to other high tech regions in Europe....
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Data on foreign regions where uranium resources are developed, 2 and 3
International Nuclear Information System (INIS)
1982-07-01
This book was published in July, 1976, before, and the revised edition was published at the beginning of 1982 as Part 1, Asia and Africa. This is Part 2, in which the regions of North America, Central and South America are reported, and Part 3 concerning Australian regions. The state of resource exploration and development, the policy of uranium mining, Japanese policy to advance in, the geological features and deposits, and the promising regions in Canada, USA, various countries in Central America and South America and Australia are described. Canada is one of the promising regions in the world regarding uranium deposits, and the exploration activity is brisk. In USA, the joint exploration with US persons having the mining right is the main method, and the companies must be established to develop mines. In Australia, P.N.C. Exploration P/L continues the exploration. (Kako, I.)
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Governance in regional development planning?
DEFF Research Database (Denmark)
Galland, Daniel
2008-01-01
The purpose of this paper is to lay part of the groundwork for a new project aimed at exploring governance aspects concerned with regional development planning (RDP) in Denmark. The fundamental objective is to help establish and clarify a number of research questions to delve into the conditions...... and opportunities for anchoring and implementing such RDP. The paper mainly adopts a descriptive approach to portray tentative pathways to explore and discuss regional governance structures, procedures and practices that are being developed in establishing new RDP processes, strategies and plans....
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REGIONAL TRADE AGREEMENTS AND COMPETITION POLICY. CASE STUDY: EU, ASEAN AND NAFTA
Directory of Open Access Journals (Sweden)
Fora Andreea-Florina
2014-07-01
Full Text Available The large number of regional trade agreements notified to the World Trade Organization (WTO significantly influenced the flow of world trade. By April 2014 there had been notified 583 regional trade agreements to the WTO, of which only 379 are in force. The objective of this paper is to highlight the importance of regional trade agreements in world trade, especially the importance of establishing a regional competition policy in these agreements. The research methodology used is the analysis of legislation governing preferential trade agreements at the level of WTO, the collection and interpretation of statistical data provided by the WTO Secretariat, the case study, namely the study of literature. The paper is structured in three parts. The first part of the paper examines the basic laws based on which regional trade agreements are notified to the WTO and the evolution of these agreements in the period 1958-2013. The second part of the paper is devoted to the analysis of competition policy in regional trade agreements. In this part of the paper, to highlight the patterns of competition policy adopted under these agreements was analyzed by three case studies of competition policy in the EU, ASEAN and NAFTA. The three case studies have revealed that the three preferential trade agreements present regional competition policies with varying degrees of integration. The most complex form of competition policy is found in the European Union, because we are talking about a centralized model of competition policy. ASEAN presents a partially decentralized model, while NAFTA scrolls with a decentralized model of competition policy. The last part of the paper presents the characteristics of the four models of competition policy identified in the preferential trade agreements in force. It should be emphasized that if the initial preferential trade agreements have not put a great emphasis on the rules of competition policy, practice has shown the importance
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Method for operating a nuclear reactor with scrammable part length rod
International Nuclear Information System (INIS)
Bevilacqua, F.
1979-01-01
A new part length rod is provided which may be used to control xenon induced power oscillations but also to contribute to shutdown reactivity when a rapid shutdown of the reactor is required. The part length rod consists of a control rod with three regions. The lower control region is a longer weaker active portion separated from an upper stronger shorter poison section by an intermediate section which is a relative non-absorber of neutrons. The combination of the longer weaker control section with the upper high worth poison section permits the part length rod to be scrammed into the core. When a reactor shutdown is required but also permits the control rod to be used as a tool to control power distribution in both the axial and radial directions during normal operation
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Energy and greenhouse gas profile of the Nouvelle Aquitaine region. Release 2017
International Nuclear Information System (INIS)
Rousset, Alain; Poitevin, Lionel; Loeb, Amandine; Philippot, Herve; Rebouillat, Lea; Jacquelin, Antoine
2017-06-01
This publication first proposes graphs and comments characterising final energy consumption of the Nouvelle Aquitaine region: regional situation in 2015 (analysis per sector and per energy), primary resources, social-economic analysis (energy bill, level of energy poverty, burden due to old housing and commuting for households), evolution of energy consumption between 2005 and 2015 (per sector, per source of energy, evolution of energy intensity and of the energy bill). The next part addresses greenhouse gas emissions: regional situation in 2015 (distribution in terms of emission type and per gas), evolutions between 1990 and 2015, evolutions per sector. The third part addresses renewable energies: regional situation for the different types of renewable energy, comparison with final energy consumption, comparison with national data, production evolutions, focus per sector (wood and wood by-products, heat pumps in the housing sector, urban waste valorisation units, biogas valorisation, bio-fuels, wind energy, hydroelectricity, solar photovoltaic). The last part recalls national objectives related to energy, to greenhouse gas emissions for France and for the region, in relationship with the law on energy transition and for a green growth
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Overview of the regional geology of the Paradox Basin Study Region
International Nuclear Information System (INIS)
1983-03-01
The Geologic Project Manager for the Paradox Basin Salt Region (PBSR), Woodward-Clyde Consultants, has conducted geologic studies to characterize the region and evaluate selected geologic formations as potential repositories for the storage and disposal of nuclear waste. Evaluations have been made from the standpoint of engineering feasibility, safety, public health, and resource conflicts. The Regulatory Project Manager for the PBSR, Bechtel National, Inc., has performed environmental characterizations to ensure that data on ecological, socioeconomic, and other environmental factors required by the National Environmental Policy Act of 1969 are considered. This report characterizes, at a regional overview level of detail, the Paradox Basin Study Region Geology. Information sources include the published literature, field trip guidebooks, open file data of the US Geological Survey (USGC) and Utah Geologic and Mineral Survey, university theses, Geo-Ref Computer Search, and various unpublished sources of subsurface data such as well logs. Existing information has been synthesized and characterized. No field work was conducted as part of this study. Where possible, attempts were made to evaluate the data. All results of this study are subject to change as more data become available
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Arrighi, Jean-Thomas; Lafleur, Jean-Michel
2017-01-01
The article constitutes the first systematic attempt to survey and account for the enfranchisement of non-resident citizens in regional elections. Shifting the focus away from the state to the regional demos, it is divided into two parts. First, it examines whether the spectacular horizontal diffusion of external voting legislation widely observed in existing scholarship has also spread vertically to regional elections, through a comparative overview of the conditions of eligibility to the re...
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Vliv strategického plánování na rozvoj obcí a regionů
SLÁDKOVÁ, Lucie
2015-01-01
This thesis is dealed with the quantification of the effects of strategic planning for the development of municipalities and regions. The first part includes the theoretical basis of the issue, especially the definition of basic concepts such as regional development, regional policy, a region, the indicators of regional development and strategic planning. In the practical part are analyzed strategic planning through the Program of the South Bohemian and Pilsen region and their strategies with...
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Ronco, P.; Gallina, V.; Torresan, S.; Zabeo, A.; Semenzin, E.; Critto, A.; Marcomini, A.
2014-07-01
KR-RRA methodology is based on the concept of risk being function of hazard, exposure and vulnerability. It integrates the outputs of various hydrodynamics models (hazard) with sito-specific bio-geophysical and socio-economic indicators (e.g. slope, land cover, population density, economic activities) to develop tailored risk indexes and GIS-based maps for each of the selected targets (i.e. people, buildings, infrastructures, agriculture, natural and semi-natural systems, cultural heritages) in the considered region, by comparing the baseline scenario with alternative scenarios, where different structural and/or non-structural mitigation measures are planned. As demonstrated in the companion paper (Part 2, Ronco et al., 2014), risk maps, along with related statistics, allow to identify and prioritize relative hotspots and targets which are more likely to be affected by flood and support the development of relevant and strategic adaptation and prevention measures to minimizing flood impacts. Moreover, the outputs of the RRA methodology can be used for the economic evaluation of different damages (e.g. tangible costs, intangible costs) and for the social assessment considering the benefits of the human dimension of vulnerability (i.e. adaptive and coping capacity).
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In-situ measurements of seismic velocities in the San Francisco Bay region...part II
Gibbs, James F.; Fumal, Thomas E.; Borcherdt, Roger D.
1976-01-01
Seismic wave velocities (compressional and shear) are important parameters for determining the seismic response characteristics of various geologic units when subjected to strong earthquake ground shaking. Seismic velocities of various units often show a strong correlation with the amounts of damage following large earthquakes and have been used as a basis for certain types of seismic zonation studies. Currently a program is in progress to measure seismic velocities in the San Francisco Bay region at an estimated 150 sites. At each site seismic travel times are measured in drill holes, normally at 2.5-m intervals to a depth of 30 m. Geologic logs are determined from drill hole cuttings, undisturbed samples, and penetrometer samples. The data provide a detailed comparison of geologic and seismic characteristics and provide parameters for estimating strong earthquake ground motions quantitatively at each of the site. A major emphasis of this program is to obtain a detailed comparison of geologic and seismic data on a regional scale for use in seismic zonation. The broad data base available in the San Francisco Bay region suggests using the area as a pilot area for the development of general techniques applicable to other areas.
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Dmitriy Aleksandrovich Izotov
2014-01-01
The author uses Russian and Chinese sources of information to analyze the current status and evaluate realization prospects of investment projects within the Cooperation Program between eastern regions of Russia and northeast China. State budget financed construction of transport and border infrastructure is being implemented as planned both in Russia and China. Sectoral distribution of key Program projects is found to be unbalanced: Russian regions specialize in mining and primary processing...
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Restaurant quality: the case of Central Slovenian region
Uran Maravić, Maja
2016-01-01
The purpose – This study has two key goals. The first part presents and compares different expert systems for assessing quality in the restaurants alongside the Ljubljana Quality Selection assessment methodology - LQS. In the second part, this study presents the results of a restaurant assessment in the Central Slovenian region using the LQS methodology. Design/methodology – In the first part of the study, we compare restaurant assessment systems through different criteria. In the second p...
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REGIONAL SECURITY IN THE HORN OF AFRICA: CONFLICTS, AGENDAS AND THREATS
Directory of Open Access Journals (Sweden)
Nilton César Fernandes Cardoso
2017-01-01
Full Text Available This paper aims at analyzing security dynamics in the Horn of Africa in the post-independence period, identifying the actors, agendas and threats. For this purpose, it is subdivided into three parts. The first one analyzes the security dynamics taking place in the Horn of Africa during the Cold War period, focusing on the regional rivalries and on the penetration of extraregional actors. In the second part, there is a discussion regarding the transformations which occurred in region in the immediate post-Cold War period, focusing both on the unities’ (states internal security dynamics and on the regional ones. The third and last section aims at identifying “new” threats and regional and international responses, as well as the emerging strategic importance of the region to traditional superpowers in the post-9/11 period, marked by the process of securitization.
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Directory of Open Access Journals (Sweden)
Taher Osman
2016-06-01
Full Text Available This paper discusses the driving forces (DFs of informal urbanization (IU in the greater Cairo metropolitan region (GCMR using the Analytic Hierarchy Process (AHP. The IU patterns in the GCMR have been extremely influenced by seven DFs: geographical characteristics, availability of life facilities, economic incentives, land demand and supply, population increase, administrative function, and development plans. This research found that these forces vary significantly in how they influence urban growth in the three study sectors, namely, the middle, north, and south areas in the western part of the GCMR. The forces with the highest influence were economic incentives in the middle sector, population increase in the north sector, and the administrative function in the south sector. Due to the lower availability of buildable land in the middle sector, the land demand and supply force had a lesser influence in this sector compared to in the north and south sectors. The development plans force had medium influence in all sectors. The geographical characteristics force had little influence in both the middle and the north sectors, but higher influence than economic incentives, availability of life facilities, and development plans in the south sector. Because of the spatial variances in life facilities organizations in the GCMR, the life facilities availability force had little effect on IU in the south sector.
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Regional cooperative agreement for the Asia and Pacific region
International Nuclear Information System (INIS)
Anon.
1981-01-01
Among the means available to the International Atomic Energy Agency to promote cooperative efforts in the nuclear field is the Regional Cooperative Agreement (RCA) for Research, Development, and Training related to Nuclear Science and Technology for the Asia and Pacific Region. Under the terms of this agreement, which came into force on June 12, 1972, participating countries aim to promote and coordinate research, development, and training projects in nuclear fields through collaborative efforts among relevant national institutions in the region. The Agency's role is to provide organizational, administrative, advisory, technical, and financial assistance when needed to secure successful execution of the projects undertaken within the framework of the RCA. Although this presentation deals primarily with the benefits of regional cooperation under the agreement, a review of the RCA would be somewhat imbalanced without a mention of its shortcomings. One of the principal impediments to more rapid progress, as is the case in many other areas, is financing. There is no stable source of funding outside the research contract program and, the likelihood of large-scale UNDP support notwithstanding, a greater willingness on the part of participating Member States to support the program along with the development of a greater sense of common purpose are called for. In this connection serious consideration is being given to the possibility of establishing an Asian Centre for Research and Training, an institute that would bring together scientists from the region to collaborate on problems common to the RCA countries. A study group has already been convened to investigate the feasibility of this proposal
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Directory of Open Access Journals (Sweden)
Takehiro Minamoto
Full Text Available Different people make different responses when they face a frustrating situation: some punish others (extrapunitive, while others punish themselves (intropunitive. Few studies have investigated the neural structures that differentiate extrapunitive and intropunitive individuals. The present fMRI study explored these neural structures using two different frustrating situations: an ego-blocking situation which blocks a desire or goal, and a superego-blocking situation which blocks self-esteem. In the ego-blocking condition, the extrapunitive group (n = 9 showed greater activation in the bilateral ventrolateral prefrontal cortex, indicating that these individuals prefer emotional processing. On the other hand, the intropunitive group (n = 9 showed greater activation in the left dorsolateral prefrontal cortex, possibly reflecting an effortful control for anger reduction. Such patterns were not observed in the superego-blocking condition. These results indicate that the prefrontal cortex is the source of individual differences in aggression direction in the ego-blocking situation.
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Factorization in the central region of inclusive reactions
International Nuclear Information System (INIS)
Kellett, B.H.; Joshi, G.C.; Lo, S.Y.
1978-01-01
Detailed factorization predictions for inclusive π +- production in the central region are compared with the available data. If account is taken of possible leading-particle effects extending into the central region at low energies, there is substantial agreement with factorization for both the energy-independent and the energy-dependent parts of the inclusive cross-sections. (author)
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The arcuate nucleus of the C57BL/6J mouse hindbrain is a displaced part of the inferior olive.
Fu, Yu Hong; Watson, Charles
2012-01-01
The arcuate nucleus is a prominent cell group in the human hindbrain, characterized by its position on the pial surface of the pyramid. It is considered to be a precerebellar nucleus and has been implicated in the pathology of several disorders of respiration. An arcuate nucleus has not been convincingly demonstrated in other mammals, but we have found a similarly positioned nucleus in the C57BL/6J mouse. The mouse arcuate nucleus consists of a variable group of neurons lying on the pial surface of the pyramid. The nucleus is continuous with the ventrolateral part of the principal nucleus of the inferior olive and both groups are calbindin positive. At first we thought that this mouse nucleus was homologous with the human arcuate nucleus, but we have discovered that the neurons of the human nucleus are calbindin negative, and are therefore not olivary in nature. We have compared the mouse arcuate neurons with those of the inferior olive in terms of molecular markers and cerebellar projection. The neurons of the arcuate nucleus and of the inferior olive share three major characteristics: they both contain neurons utilizing glutamate, serotonin or acetylcholine as neurotransmitters; they both project to the contralateral cerebellum, and they both express a number of genes not present in the major mossy fiber issuing precerebellar nuclei. Most importantly, both cell groups express calbindin in an area of the ventral hindbrain almost completely devoid of calbindin-positive cells. We conclude that the neurons of the hindbrain mouse arcuate nucleus are a displaced part of the inferior olive, possibly separated by the caudal growth of the pyramidal tract during development. The arcuate nucleus reported in the C57BL/6J mouse can therefore be regarded as a subgroup of the rostral inferior olive, closely allied with the ventral tier of the principal nucleus. Copyright © 2012 S. Karger AG, Basel.
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Directory of Open Access Journals (Sweden)
Kuznetsov A. V.
2012-01-01
Full Text Available The paper examines flows of foreign direct investment within the Baltic region. The author demonstrates close investment ties among the EU members, which are of special importance for Estonia, Latvia and Lithuania. Transborder corporate integration in the region is characterized by significant imbalances. In many aspects, it can be viewed as Sweden’s economic expansion or development of domestic markets for northern European companies. Although many German, Polish and Russian companies are involved in corporate integration in the Baltic region, other vectors of their foreign economic relations are still more important for them. As a result, the integration of Russian business in the Baltic part of the European integration area is still rather weak despite Russia’s considerable foreign direct investment in the Baltic States.
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ROMANIAN FOREIGN TRADE - A REGIONAL PERSPECTIVE
Directory of Open Access Journals (Sweden)
Gabriela Carmen Pascariu
2010-03-01
Full Text Available The increasing integration of Romania in the global economy is a reality of the last years, proved through a constant growth of the foreign trade with other countries, which exceeded, in terms ofdynamics, both GDP and industrial production. In the first part of our paper, we intend to analyze the evolution of Romanian foreign trade in the period 1995-2007, focusing on the proportions of the imports and exports, at regional level. We wish to emphasize the correlations between the indicators that describe the degree of openness to foreign trade and indicators of competitiveness and specialization in different industries. The main goal of our approach is to highlight the sectors which generate comparative advantages and potential competitiveness poles, contributing significantly to the increase of the Romanian economy, expressed in GDP/capita. In the second part of the paper, based on the frame of analysis and interpretation defined and implemented in the first part, we intend to establish if the agglomeration processes in some regions of ourcountry will lead gradually to the strengthening of growth poles and, therefore to boost the foreign trade.
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Barsky, Carl
This report presents the results of a survey conducted by the Bureau of Labor Statistics to determine wages and related benefits in (1) the banking industry and (2) for employees in home offices and regional head offices of life insurance carriers. Part 1 discusses banking industry characteristics and presents data for tellers and selected…
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Economic Growth, Convergence and Innovation in the EU Regions
Directory of Open Access Journals (Sweden)
Tiiu Paas
2012-12-01
Full Text Available The paper focuses on quantitative assessment of the innovation’s role in explaining regional disparities and convergence in Europe. The empirical part of the study bases on the regional GDP pc and innovation indicators on the EU-27 NUTS2 level regions. Based on the selected set of initial regional innovation indicators and using the principal components factor analysis method, three composite indicators of regional innovation capacity are extracted. Estimating convergence equations, we noticed that regional innovations tend to increase inter-regional differences, at least during the short-run period. Thus, if regional income convergence is a policy target, additional policy measures beside innovation activities should be effectively implemented.
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Increased GABA(A) inhibition of the RVLM after hindlimb unloading in rats
Moffitt, Julia A.; Heesch, Cheryl M.; Hasser, Eileen M.
2002-01-01
Attenuated baroreflex-mediated increases in renal sympathetic nerve activity (RSNA) in hindlimb unloaded (HU) rats apparently are due to changes within the central nervous system. We hypothesized that GABA(A) receptor-mediated inhibition of the rostral ventrolateral medulla (RVLM) is increased after hindlimb unloading. Responses to bilateral microinjection of the GABA(A) antagonist (-)-bicuculline methiodide (BIC) into the RVLM were examined before and during caudal ventrolateral medulla (CVLM) inhibition in Inactin-anesthetized control and HU rats. Increases in mean arterial pressure (MAP), heart rate (HR), and RSNA in response to BIC in the RVLM were significantly enhanced in HU rats. Responses to bilateral CVLM blockade were not different. When remaining GABA(A) inhibition in the RVLM was blocked by BIC during CVLM inhibition, the additional increases in MAP and RSNA were significantly greater in HU rats. These data indicate that GABA(A) receptor-mediated inhibition of RVLM neurons is augmented after hindlimb unloading. Effects of input from the CVLM were unaltered. Thus, after cardiovascular deconditioning in rodents, the attenuated increase in sympathetic nerve activity in response to hypotension is associated with greater GABA(A) receptor-mediated inhibition of RVLM neurons originating at least in part from sources other than the CVLM.
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Nuclear developments in the Asia and Pacific region
International Nuclear Information System (INIS)
McMillan, M.J.; Silver, J.M.
1993-07-01
Countries in this part of the world are engaged in many aspects of nuclear science and technology, often as part of a national development plan. A number of them are members of the Regional Cooperative Agreement (RCA) for Research, Development and Training Related to Nuclear Science and Technology which was developed under the auspices of the International Atomic Energy Agency to provide a basis for nuclear technical assistance and cooperation in the Asia and Pacific region. In contrast to North America and most of western Europe, where growth in installed nuclear generating capacity has ceased, a number of regional countries are planning, ordering and building new power reactors to meet their increasing demands for electricity. Major fuel cycle facilities, such as commercial enrichment and reprocessing plants in Japan, are also being developed. This report describes nuclear developments from power and research reactors to reprocessing facilities in countries of the Asia and Pacific region listed in alphabetical order. Power Reactor and Research Reactors programs in the region as well as lists of regional centres with irradiation facilities are presented in the appendixes The information was gathered from a range of sources, including relevant journals, publications of the International Atomic Energy Agency (IAEA), the OECD/Nuclear Energy Agency(NEA), and annual reports of national nuclear institutes. 1 tab., ill
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Region effects influence local tree species diversity.
Ricklefs, Robert E; He, Fangliang
2016-01-19
Global patterns of biodiversity reflect both regional and local processes, but the relative importance of local ecological limits to species coexistence, as influenced by the physical environment, in contrast to regional processes including species production, dispersal, and extinction, is poorly understood. Failure to distinguish regional influences from local effects has been due, in part, to sampling limitations at small scales, environmental heterogeneity within local or regional samples, and incomplete geographic sampling of species. Here, we use a global dataset comprising 47 forest plots to demonstrate significant region effects on diversity, beyond the influence of local climate, which together explain more than 92% of the global variation in local forest tree species richness. Significant region effects imply that large-scale processes shaping the regional diversity of forest trees exert influence down to the local scale, where they interact with local processes to determine the number of coexisting species.
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Parquet: Regions of areal plastic dislocations (on Venus)
Sukhanov, A. L.
1986-01-01
The extensive flat elevations of the Northern Hemisphere of Venus are covered with frequently intersecting lines of dislocations, resembling the outline of a giant parquet. In the internal sections of these regions we find grabens and regions of extension, and on the periphery lobe-shaped flow structures. The parquet was formed after the beginning of the formation of the lava plains, but covered by the youngest lava. These structures apparently arose partly because of the dragging of blocks of crust by the asthenospheric flows, and partly in the gravitational sliding of such heated blocks in the partial melting of their base. It is possible that these elevations occupy on Venus the place of the Earth's rift systems.
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Lennington, Jessica B; Pope, Sara; Goodheart, Anna E; Drozdowicz, Linda; Daniels, Stephen B; Salamone, John D; Conover, Joanne C
2011-09-14
Coordinated regulation of the adult neurogenic subventricular zone (SVZ) is accomplished by a myriad of intrinsic and extrinsic factors. The neurotransmitter dopamine is one regulatory molecule implicated in SVZ function. Nigrostriatal and ventral tegmental area (VTA) midbrain dopamine neurons innervate regions adjacent to the SVZ, and dopamine synapses are found on SVZ cells. Cell division within the SVZ is decreased in humans with Parkinson's disease and in animal models of Parkinson's disease following exposure to toxins that selectively remove nigrostriatal neurons, suggesting that dopamine is critical for SVZ function and nigrostriatal neurons are the main suppliers of SVZ dopamine. However, when we examined the aphakia mouse, which is deficient in nigrostriatal neurons, we found no detrimental effect to SVZ proliferation or organization. Instead, dopamine innervation of the SVZ tracked to neurons at the ventrolateral boundary of the VTA. This same dopaminergic neuron population also innervated the SVZ of control mice. Characterization of these neurons revealed expression of proteins indicative of VTA neurons. Furthermore, exposure to the neurotoxin MPTP depleted neurons in the ventrolateral VTA and resulted in decreased SVZ proliferation. Together, these results reveal that dopamine signaling in the SVZ originates from a population of midbrain neurons more typically associated with motivational and reward processing.
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Wang, Nini; Yin, Jianchuan
2017-12-01
A precipitation-based regionalization for the Tibetan Plateau (TP) was investigated for regional precipitation trend analysis and frequency analysis using data from 1113 grid points covering the period 1900-2014. The results utilizing self-organizing map (SOM) network suggest that four clusters of precipitation coherent zones can be identified, including the southwestern edge, the southern edge, the southeastern region, and the north central region. Regionalization results of the SOM network satisfactorily represent the influences of the atmospheric circulation systems such as the East Asian summer monsoon, the south Asian summer monsoon, and the mid-latitude westerlies. Regionalization results also well display the direct impacts of physical geographical features of the TP such as orography, topography, and land-sea distribution. Regional-scale annual precipitation trend as well as regional differences of annual and seasonal total precipitation were investigated by precipitation index such as precipitation concentration index (PCI) and Standardized Anomaly Index (SAI). Results demonstrate significant negative long-term linear trends in southeastern TP and the north central part of the TP, indicating arid and semi-arid regions in the TP are getting drier. The empirical mode decomposition (EMD) method shows an evolution of the main cycle with 4 and 12 months for all the representative grids of four sub-regions. The cross-wavelet analysis suggests that predominant and effective period of Indian Ocean Dipole (IOD) on monthly precipitation is around ˜12 months, except for the representative grid of the northwestern region.
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Groundwater circulation in deep carbonate regions
Szönyi-Mádl, Judit; Tóth, Ádám
2016-04-01
The operation of the subsurface part of the hydrologic cycle is hardly understood on basin scale due to the limitation in validated knowledge. Therefore the water balance approach is used with simplified numerical approaches during solving water related problems. The understanding of hierarchical nature of gravity-driven groundwater flow in near-surface and other driving forces in the deeper part of the lithosphere are often neglected. In this context thick and deep carbonate regions are especially less understood because the applicability of the gravity-driven regional groundwater flow (GDRGF) concept for such ranges formerly was debated. This is because karst studies are focused rather on the understanding of heterogeneity of karst systems. In contrary, this study found, on the basis of REV concept, that at regional scale not the local permeability values but its regional distribution is decisive. Firstly, according to the hydraulic diffusivity values it was stated that hydraulic connectivity is more effective in basinal carbonates compared to siliciclastics. Consequently, the efficient hydraulic responses for hydraulic head changes (due to water production or injection) in a carbonate system can give an indirect clue regarding hydraulic connectivity of the system rather than understanding the detailed permeability distribution. The concerns of the applicability of the GDRGF concept, therefore could be resolved. Subsequently, the concept of GDRGF can be used as a working hypothesis for understanding basinal hydraulics and geologic agency of flowing groundwater in thick carbonate ranges (Mádl-Szonyi and Tóth 2015). The hydrogeologically complex thick carbonate system of the Transdanubian Range (TR) Hungary was used as a study area to reveal the role of GDRGF at basin scale. Water level changes in the system, due to long-term mine dewatering exemplify the hydraulic continuity and compartmentalization of the system. Clustering of spring data, numerical flow and
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Singh, S.; Tiwari, S.; Dumka, U. C.; Kumar, R.; Singh, P. K.
2017-11-01
Black carbon (BC) aerosols affect the Earth's climate directly by interacting with the solar radiation and indirectly by modifying the lifetime and optical properties of clouds. However, our understanding of BC aerosols and their impacts on the climate are limited by lack of in situ measurements of BC, especially in the developing world. This study reports measurements of BC from Dhanbad, a coalfields area of eastern India, we analyze BC data at 370 and 880 nm during 2013 to gain insight into the emission sources affecting the study area. Our analysis indicates significantly higher absorption at the lower wavelength (ultraviolet). We estimate that 33% of BC at Dhanbad comes from biomass/biofuel combustion and the remaining 67% from the fossil fuel combustion. Higher concentrations of BC370 nm (> 12 μg m- 3) were observed when the air masses affecting Dhanbad originated far away in countries like Iran, Afghanistan, Pakistan, Oman, United Arab Emirates and passed over the Indo-Gangetic Plains (IGP) prior to arriving at the observation site. The source regions affecting BC880 nm were localized over the IGP but BC880 nm concentrations are 33% lower ( 8 μg m- 3) than BC370 nm. The cluster analysis showed that the largest fraction (35 and 29%) of the air masses arriving at Dhanbad passed through the boundary layer of the central IGP and north-west IGP region during the post-monsoon season. Average values of BC370 nm (16.0 and 20.0 μg m- 3) and BC880 nm (9.5 and 10.0 μg m- 3) in the IGP influenced air masses were significantly higher than those arriving from other source regions. The Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) model were applied to understand the relative importance of different sources affecting Dhanbad. The variability of observed BC mass concentrations was captured fairly well by WRF-Chem with minor deviations from the measured values. Model results indicate that anthropogenic emissions account for more than 75% of the
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Trade in Andean Condor Vulture gryphus feathers and body parts in ...
African Journals Online (AJOL)
body parts in the city of Cusco and the Sacred Valley,. Cusco region, Peru. Robert S. R. ... The sale of Andean Condor feathers and body parts is undertaken openly in the tourist markets of Cusco and the Sacred .... and shops. Prices in local currency – Nuevo Sol and US Dollar equivalent given in parentheses). Feather.
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DEFF Research Database (Denmark)
Rekling, J C; Champagnat, J; Denavit-Saubié, M
1996-01-01
with the aim of extending the classification of inspiratory neurons to include analysis of active membrane properties. 2. The slice generated a regular rhythmic motor output recorded as burst of action potentials on a XII nerve root with a peak to peak time of 11.5 +/- 3.4 s and a duration of 483 +/- 54 ms......1. The electrophysiological properties of inspiratory neurons were studied in a rhythmically active thick-slice preparation of the newborn mouse brain stem maintained in vitro. Whole cell patch recordings were performed from 60 inspiratory neurons within the rostral ventrolateral part of the slice...
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Měření produktivity v podniku a na regionální úrovni
KUŽEL, Jiří
2013-01-01
The aim of the Diploma´s work was to explain the concept of corporate and regional productivity and possibility of evaluation. Furthermore to analyze the development of value added on the basis of the specific enterprise data and at the regional level. The theoretical part described the concept of productivity and factors of production. Then followed a description of the business concept of productivity, the possibility of evaluation and rating of regional productivity. In the practical part ...
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Directory of Open Access Journals (Sweden)
Marco De Nardi
2017-10-01
Full Text Available A training and outreach program to increase public awareness of African swine fever (ASF was implemented by Defense Threat Reduction Agency and the Ministries of Agriculture in Armenia, Georgia, Kazakhstan, and Ukraine. The implementing agency was the company SAFOSO (Switzerland. Integration of this regional effort was administered by subject matter experts for each country. The main teaching effort of this project was to develop a comprehensive regional public outreach campaign through a network of expertise and knowledge for the control and prevention of ASF in four neighboring countries that experience similar issues with this disease. Gaps in disease knowledge, legislation, and outbreak preparedness in each country were all addressed. Because ASF is a pathogen with bioterrorism potential and of great veterinary health importance that is responsible for major economic instability, the project team developed public outreach programs to train veterinarians in the partner countries to accurately and rapidly identify ASF activity and report it to international veterinary health agencies. The project implementers facilitated four regional meetings to develop this outreach program, which was later disseminated in each partner country. Partner country participants were trained as trainers to implement the outreach program in their respective countries. In this paper, we describe the development, execution, and evaluation of the ASF training and outreach program that reached more than 13,000 veterinarians, farmers, and hunters in the partner countries. Additionally, more than 120,000 booklets, flyers, leaflets, guidelines, and posters were distributed during the outreach campaign. Pre- and post-ASF knowledge exams were developed. The overall success of the project was demonstrated in that the principles of developing and conducting a public outreach program were established, and these foundational teachings can be applied within a single country or
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Tang, Chao; Morel, Béatrice; Wild, Martin; Pohl, Benjamin; Abiodun, Babatunde; Bessafi, Miloud
2018-02-01
This study evaluates the performance of climate models in reproducing surface solar radiation (SSR) over Southern Africa (SA) by validating five Regional Climate Models (RCM, including CCLM4, HIRHAM5, RACMO22T, RCA4 and REMO2009) that participated in the Coordinated Regional Downscaling Experiment program over Africa (CORDEX-Africa) along with their ten driving General Circulation Models (GCMs) from the Coupled Model Intercomparison Project Phase 5 over SA. The model simulated SSR was thereby compared to reference data from ground-based measurements, satellite-derived products and reanalyses over the period 1990-2005. Results show that (1) the references obtained from satellite retrievals and reanalyses overall overestimate SSR by up to 10 W/m2 on average when compared to ground-based measurements from the Global Energy Balance Archive, which are located mainly over the eastern part of the southern African continent. (2) Compared to one of the satellite products (Surface Solar Radiation Data Set—Heliosat Edition 2; SARAH-2): GCMs overestimate SSR over SA in terms of their multi-model mean by about 1 W/m2 (compensation of opposite biases over sub-regions) and 7.5 W/m2 in austral summer and winter respectively; RCMs driven by GCMs show in their multimodel mean underestimations of SSR in both seasons with Mean Bias Errors (MBEs) of about - 30 W/m2 in austral summer and about - 14 W/m2 in winter compared to SARAH-2. This multi-model mean low bias is dominated by the simulations of the CCLM4, with negative biases up to - 76 W/m2 in summer and - 32 W/m2 in winter. (3) The discrepancies in the simulated SSR over SA are larger in the RCMs than in the GCMs. (4) In terms of trend during the "brightening" period 1990-2005, both GCMs and RCMs (driven by European Centre for Medium-Range Weather Forecasts Reanalysis ERA-Interim, short as ERAINT and GCMs) simulate an SSR trend of less than 1 W/m2 per decade. However, variations of SSR trend exist among different references data
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Taylor, Tamra Faris
This publication contains a detailed list of the birds, mammals, fish, amphibians, reptiles, and invertebrates found in Alaska. Part I lists the species by geographical regions. Part II lists the species by the ecological regions of the state. (CO)
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The history of safety factors for Dutch regional dykes
De Gast, T.; Vardon, P.J.; Jommi, C.; Hicks, M.A.
2015-01-01
Regular dyke assessment is part of reducing the risk of flooding in the Netherlands. 18 000 km of dykes are assessed at regular intervals, of which 14 000 km are classified as regional dykes and their main aim is to defend polders from inundating. The methods of assessing regional dykes are strongly
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The History of Safety Factors for Dutch Regional Dykes
De Gast, T.; Vardon, P.J.; Jommi, C.; Hicks, M.A.
2015-01-01
Regular dyke assessment is part of reducing the risk of flooding in the Netherlands. 18 000 km of dykes are assessed at regular intervals, of which 14 000 km are classified as regional dykes and their main aim is to defend polders from inundating. The methods of assessing regional dykes are strongly
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Gómez, I.; Estrela, M.
2009-09-01
Extreme temperature events have a great impact on human society. Knowledge of minimum temperatures during winter is very useful for both the general public and organisations whose workers have to operate in the open, e.g. railways, roadways, tourism, etc. Moreover, winter minimum temperatures are considered a parameter of interest and concern since persistent cold-waves can affect areas as diverse as public health, energy consumption, etc. Thus, an accurate forecasting of these temperatures could help to predict cold-wave conditions and permit the implementation of strategies aimed at minimizing the negative effects that low temperatures have on human health. The aim of this work is to evaluate the skill of the RAMS model in determining daily minimum temperatures during winter over the Valencia Region. For this, we have used the real-time configuration of this model currently running at the CEAM Foundation. To carry out the model verification process, we have analysed not only the global behaviour of the model for the whole Valencia Region, but also its behaviour for the individual stations distributed within this area. The study has been performed for the winter forecast period from 1 December 2007 - 31 March 2008. The results obtained are encouraging and indicate a good agreement between the observed and simulated minimum temperatures. Moreover, the model captures quite well the temperatures in the extreme cold episodes. Acknowledgement. This work was supported by "GRACCIE" (CSD2007-00067, Programa Consolider-Ingenio 2010), by the Spanish Ministerio de Educación y Ciencia, contract number CGL2005-03386/CLI, and by the Regional Government of Valencia Conselleria de Sanitat, contract "Simulación de las olas de calor e invasiones de frío y su regionalización en la Comunidad Valenciana" ("Heat wave and cold invasion simulation and their regionalization at Valencia Region"). The CEAM Foundation is supported by the Generalitat Valenciana and BANCAIXA (Valencia
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Gómez, I.; Estrela, M.
2009-09-01
Extreme temperature events have a great impact on human society. Knowledge of summer maximum temperatures is very useful for both the general public and organisations whose workers have to operate in the open, e.g. railways, roadways, tourism, etc. Moreover, summer maximum daily temperatures are considered a parameter of interest and concern since persistent heat-waves can affect areas as diverse as public health, energy consumption, etc. Thus, an accurate forecasting of these temperatures could help to predict heat-wave conditions and permit the implementation of strategies aimed at minimizing the negative effects that high temperatures have on human health. The aim of this work is to evaluate the skill of the RAMS model in determining daily maximum temperatures during summer over the Valencia Region. For this, we have used the real-time configuration of this model currently running at the CEAM Foundation. To carry out the model verification process, we have analysed not only the global behaviour of the model for the whole Valencia Region, but also its behaviour for the individual stations distributed within this area. The study has been performed for the summer forecast period of 1 June - 30 September, 2007. The results obtained are encouraging and indicate a good agreement between the observed and simulated maximum temperatures. Moreover, the model captures quite well the temperatures in the extreme heat episodes. Acknowledgement. This work was supported by "GRACCIE" (CSD2007-00067, Programa Consolider-Ingenio 2010), by the Spanish Ministerio de Educación y Ciencia, contract number CGL2005-03386/CLI, and by the Regional Government of Valencia Conselleria de Sanitat, contract "Simulación de las olas de calor e invasiones de frío y su regionalización en la Comunidad Valenciana" ("Heat wave and cold invasion simulation and their regionalization at Valencia Region"). The CEAM Foundation is supported by the Generalitat Valenciana and BANCAIXA (Valencia, Spain).
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Regional competitiveness: The case of Western China
Directory of Open Access Journals (Sweden)
Vuković Darko
2010-01-01
Full Text Available This paper explains the concept of regional competitiveness and the factors that influence on it. A large number of various authors explain this concept, based on its different aspects, including: productivity, mikroaspekts (firm, quality of human capital, innovation, technology, infrastructure, social capital, etc.. Taking into account complex nature of regional competitiveness, it is difficult to determine a standard definition of this term. The second part of this paper refers to the case of western China. Substantial disparity in regional development is a reality in every geographically large country, and the causes of the disparity are numerous and complex. Regional inequality has been an important issue in China. This paper generally summarized China's Western regions geography, government policies and development situation. The authors put forward some practical strategies on how to help the western regions create a favorable environment to attract national and international investment.
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32 CFR Appendix B to Part 290 - DCAA's FOIA Points of Contact
2010-07-01
... (CONTINUED) FREEDOM OF INFORMATION ACT PROGRAM DEFENSE CONTRACT AUDIT AGENCY (DCAA) FREEDOM OF INFORMATION ACT PROGRAM Pt. 290, App. B Appendix B to Part 290—DCAA's FOIA Points of Contact (Regional Offices.... Pacific Ocean and Asian Islands. Asia except the Middle East. Australia. Georgia DCAA Eastern Regional...
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The regional approach and regional studies method in the process of geography teaching
Dermendzhieva, Stela; Doikov, Martin
2017-03-01
We define the regional approach as a manner of relations among the global trends of development of the "Society-man-nature" system and the local differentiating level of knowledge. Conditionally, interactions interlace under the influence of the character of Geography as a science, education, approaches, goals and teaching methods. Global, national and local development differentiates in three concentric circles at the level of knowledge. It is determined as a conception of modern, complex and effective mechanism for young people, through which knowledge develops in regional historical and cultural perspective; self-consciousness for socio-economic and cultural integration is formed as a part of the. historical-geographical image of the native land. This way an attitude to the. native land is formed as a connecting construct between patriotism to the motherland and the same in global aspect. The possibility for integration and cooperation of the educative geographical content with all the local historical-geographical, regional, profession orientating, artistic, municipal and district institutions, is outlined. Contemporary geographical education appears to be a powerful and indispensable mechanism for organization of human sciences, while the regional approach and the application of the regional studies method stimulate and motivate the development and realization of optimal capacities for direct connection with the local structures and environments.
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Regionalism, Regionalization and Regional Development
Directory of Open Access Journals (Sweden)
Liviu C. Andrei
2016-03-01
Full Text Available Sustained development is a concept associating other concepts, in its turn, in the EU practice, e.g. regionalism, regionalizing and afferent policies, here including structural policies. This below text, dedicated to integration concepts, will limit on the other hand to regionalizing, otherwise an aspect typical to Europe and to the EU. On the other hand, two aspects come up to strengthen this field of ideas, i.e. the region (al-regionalism-(regional development triplet has either its own history or precise individual outline of terms.
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Leitch, Sharon; Dovey, Susan M
2010-12-01
By the time medical students graduate many wish to work part-time while accommodating other lifestyle interests. To review flexibility of medical registration requirements for provisional registrants in New Zealand, Australia, the United Kingdom, Ireland and Canada. Internet-based review of registration bodies of each country, and each state or province in Australia and Canada, supplemented by emails and phone calls seeking clarification of missing or obscure information. Data from 20 regions were examined. Many similarities were found between study countries in their approaches to the registration of new doctors, although there are some regional differences. Most regions (65%) have a provisional registration period of one year. Extending this period was possible in 91% of regions. Part-time options were possible in 75% of regions. All regions required trainees to work in approved practice settings. Only the UK provided comprehensive documentation of their requirements in an accessible format and clearly explaining the options for part-time work. Australia appeared to be more flexible than other countries with respect to part- and full-time work requirements. All countries need to examine their registration requirements to introduce more flexibility wherever possible, as a strategy for addressing workforce shortages.
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GRAbB : Selective Assembly of Genomic Regions, a New Niche for Genomic Research
Brankovics, Balázs; Zhang, Hao; van Diepeningen, Anne D; van der Lee, Theo A J; Waalwijk, Cees; de Hoog, G Sybren
GRAbB (Genomic Region Assembly by Baiting) is a new program that is dedicated to assemble specific genomic regions from NGS data. This approach is especially useful when dealing with multi copy regions, such as mitochondrial genome and the rDNA repeat region, parts of the genome that are often
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Spatial scaling of regional strategic programmes in Finland
DEFF Research Database (Denmark)
Makkonen, Teemu; Inkinen, Tommi
2014-01-01
framework. Spatial scales proved to be a black box for regional strategies in Finland. Regional strategic programmes use a similar language that ignores the spatial variations of their locations. Clusters and regional innovation systems should be considered as parts of vertical and horizontal interlinkages...... within the economy and not as individual islands of organizational proximities in isolated contexts. It is argued here that an imprecise understanding of the innovation systems and cluster approaches, both conceptually and practically, has led to some ambiguity, resulting in the use of these terms...
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Regional Densification of a Global VTEC Model Based on B-Spline Representations
Erdogan, Eren; Schmidt, Michael; Dettmering, Denise; Goss, Andreas; Seitz, Florian; Börger, Klaus; Brandert, Sylvia; Görres, Barbara; Kersten, Wilhelm F.; Bothmer, Volker; Hinrichs, Johannes; Mrotzek, Niclas
2017-04-01
The project OPTIMAP is a joint initiative of the Bundeswehr GeoInformation Centre (BGIC), the German Space Situational Awareness Centre (GSSAC), the German Geodetic Research Institute of the Technical University Munich (DGFI-TUM) and the Institute for Astrophysics at the University of Göttingen (IAG). The main goal of the project is the development of an operational tool for ionospheric mapping and prediction (OPTIMAP). Two key features of the project are the combination of different satellite observation techniques (GNSS, satellite altimetry, radio occultations and DORIS) and the regional densification as a remedy against problems encountered with the inhomogeneous data distribution. Since the data from space-geoscientific mission which can be used for modeling ionospheric parameters, such as the Vertical Total Electron Content (VTEC) or the electron density, are distributed rather unevenly over the globe at different altitudes, appropriate modeling approaches have to be developed to handle this inhomogeneity. Our approach is based on a two-level strategy. To be more specific, in the first level we compute a global VTEC model with a moderate regional and spectral resolution which will be complemented in the second level by a regional model in a densification area. The latter is a region characterized by a dense data distribution to obtain a high spatial and spectral resolution VTEC product. Additionally, the global representation means a background model for the regional one to avoid edge effects at the boundaries of the densification area. The presented approach based on a global and a regional model part, i.e. the consideration of a regional densification is called the Two-Level VTEC Model (TLVM). The global VTEC model part is based on a series expansion in terms of polynomial B-Splines in latitude direction and trigonometric B-Splines in longitude direction. The additional regional model part is set up by a series expansion in terms of polynomial B-splines for
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Deep mycoses in Amazon region.
Talhari, S; Cunha, M G; Schettini, A P; Talhari, A C
1988-09-01
Patients with deep mycoses diagnosed in dermatologic clinics of Manaus (state of Amazonas, Brazil) were studied from November 1973 to December 1983. They came from the Brazilian states of Amazonas, Pará, Acre, and Rondônia and the Federal Territory of Roraima. All of these regions, with the exception of Pará, are situated in the western part of the Amazon Basin. The climatic conditions in this region are almost the same: tropical forest, high rainfall, and mean annual temperature of 26C. The deep mycoses diagnosed, in order of frequency, were Jorge Lobo's disease, paracoccidioidomycosis, chromomycosis, sporotrichosis, mycetoma, cryptococcosis, zygomycosis, and histoplasmosis.
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Subotica municipality as a learning region
Directory of Open Access Journals (Sweden)
Pantić Marijana
2007-01-01
Full Text Available Some differences in territorial organization between Serbian and EU countries are obvious. The level of centralization and tradition in systems for implementation of ideas are differently back- grounded. However, these are the most important facts for the opportunity to realize Learning Region as a concept of the European future. There is no part of space that should be considered as unchangeable and the way to a better position and Learning Region concept implementation of each region in Serbia in practice should lead towards few necessary steps and further. The starting point is awareness of the facts on the creation of Subotica region as it is at present. The healthy future of each region is provided by looking back in the past and learning from the history. The other important thing is bench marking- learning on the positive and successful experiences of other regions, and finally, making its own concept of Learning Region adapted to local surrounding and true need of local people. Some experiences, suggestions and comparisons will be made in this case study, in relation to one of the Serbian municipalities nearest t to EU neighboring countries in a territorial way. .
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Efeitos da atividade física de intensidades variadas em ratos com hipertensão renovascular 2R1CL
Soares, Everton Rocha
2008-01-01
VII Na hipertensão arterial (HA) ocorre uma inabilidade dos neurônios do bulbo ventrolateral caudal (CVLM) em contrabalancear o aparente aumento da atividade dos neurônios do bulbo ventrolateral rostral (RVLM). Além disso, o aumento da atividade do sistema renina angiotensina (SRA) representa uma importante alteração hormonal que leva à hipertensão, por aumentar o tônus vasomotor simpático e prejudicar a função barorreflexa. A atividade física (AF) de baixa e moderada intensidade tem sido usa...
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Social attitudes and regional inequalities
Directory of Open Access Journals (Sweden)
Vinko Muštra
2014-03-01
Full Text Available As the budgets of the European Union (EU become tighter, the questions about the effectiveness of EU’s expenditure, especially the most important parts such as Cohesion policy, are hotly debated. The aim of this paper is to examine whether the presence of social attitudes may influence the effectiveness of EU budget expenditure, measured by the level of regional inequalities. The analysis starts by focusing on individuals’ attitudes towards income from their own effort and income which is derived from other people’s effort, having in mind that individual actions depend on their attitudes. The next step establishes the link between the income from other people’s effort with the re-distributive dimension of the EU budget, considering that different attitudes among individuals in the EU could lead to significant differences in effectiveness of this redistributive policy among European regions and, consequently, diverse regional inequalities. Empirical research uses data for 27 EU countries observed over two waves of European Value Surveys: 1999-2000 (Wave 1 and 2008–2009 (Wave 2. The results indicate a significant role of social attitudes for regional inequalities, which raises the question of the appropriateness of simplification and uniform regional policy instruments in solving EU regional problems.
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Seismic fault analysis of Chicoutimi region
International Nuclear Information System (INIS)
Woussen, G.; Ngandee, S.
1996-01-01
On November 25, 1988, an earthquake measuring 6.5 on the Richter Scale occurred at a depth of 29 km in Precambrian bedrock in the Saguenay Region (Quebec). Given that the seismic event was located near a major zone of normal faults, it is important to determine if the earthquake could be associated with this large structure or with faults associated with this structure. This is discussed through a compilation and interpretation of structural discontinuities on key outcrops in the vicinity of the epicenter. The report is broken in four parts. The first part gives a brief overview of the geology in order to provide a geologic context for the structural measurements. The second comprises an analysis of fractures in each of the three lithotectonic units defined in the first part. The third part discusses the data and the fourth provides a conclusion. 30 refs., 53 figs
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Energy Technology Data Exchange (ETDEWEB)
NONE
1991-03-01
The results of surveys conducted in the eastern part of Obanazawa region, Yamagata Prefecture, in fiscal 1988-1989 are compiled in this report. Conducted were a geological/alteration zone survey, geochemical survey, electromagnetic surveillance (TDEM - time domain electromagnetic method), gravity prospecting (review of gravity data), electric prospecting (Schlumberger method), heat flow rate survey, test boring, environmental impact survey, and so forth. Conclusions are mentioned below. It is inferred that the water of the Ginzan hot spring of the neutral Cl-SO{sub 4} type originates in meteoric water in mountains high above the mean sea level in the western side and that the hot spring water is produced when water heated to approximately 170 degrees C at a depth (1,500-2,000 meters below mean sea level) in the Ginzan hot spring district, where the ground temperature is the highest in this region, is diluted by groundwater near the surface at its ultimate stage of ascent. The survey results disclose that possibilities are quite low that a high-temperature sector of 200 degrees C or higher is found at a level not deeper than 2,000 meters from the ground surface. Accordingly, no geothermal development by flash steam power generation is feasible at the present stage at any economically acceptable depth. (NEDO)
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Takeuchi, Hikaru; Taki, Yasuyuki; Sassa, Yuko; Hashizume, Hiroshi; Sekiguchi, Atsushi; Fukushima, Ai; Kawashima, Ryuta
2011-10-01
Working memory is the limited capacity storage system involved in the maintenance and manipulation of information over short periods of time. Previous imaging studies have suggested that the frontoparietal regions are activated during working memory tasks; a putative association between the structure of the frontoparietal regions and working memory performance has been suggested based on the analysis of individuals with varying pathologies. This study aimed to identify correlations between white matter and individual differences in verbal working memory performance in normal young subjects. We performed voxel-based morphometry (VBM) analyses using T1-weighted structural images as well as voxel-based analyses of fractional anisotropy (FA) using diffusion tensor imaging. Using the letter span task, we measured verbal working memory performance in normal young adult men and women (mean age, 21.7 years, SD=1.44; 42 men and 13 women). We observed positive correlations between working memory performance and regional white matter volume (rWMV) in the frontoparietal regions. In addition, FA was found to be positively correlated with verbal working memory performance in a white matter region adjacent to the right precuneus. These regions are consistently recruited by working memory. Our findings suggest that, among normal young subjects, verbal working memory performance is associated with various regions that are recruited during working memory tasks, and this association is not limited to specific parts of the working memory network. Copyright © 2011 Elsevier Ltd. All rights reserved.
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World Economy at the Confluence between Globalization and Regionalization
Directory of Open Access Journals (Sweden)
Costel Marian DIMA
2015-12-01
Full Text Available Due to the enlargement and deepening of connections in various spheres of influence of the economic, political, social and cultural life, the problems occurring in the process of globalization are rather global than national, their solving being carried out globally instead of nationally. Thus, in economic and financial terms, globalization contributes to strengthening and enlarging the connections among national economies in the global market of goods, services and capital. In the paper first part, it is presented the current situation of globalization and the need for development at regional level. In the second part, taking into account that the regionalization process varies from country to country, depending on the economic, social, political, demographic and ethnic situation, we showed an analysis of the European Union’s policy of development and cohesion. In the last part, we brought forward the current situation of European development policy, conclusions and views concerning the theme approached.
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Bernhard Mueller
2000-01-01
For many decades of the 20th century particular cities and towns were understood as integral parts of national and international urban systems. For many years the theory on central places and hierarchy of central places, first developed by Christaller and amended by Loesch, had a decisive influence on spatial research and regional development policies with guiding principles for urbanisation and the development of settlement patterns. However it is becoming ever more evident, that the planned...
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The marketing research on potential outbound tourists in Shanghai to travel in the Kuopio region
Zhang, Hongyu
2016-01-01
Despite vast researches have been made in the tourism industry, little is known about the tourism in the Kuopio region and the sport activities. This thesis aimed to seek the potential outbound tourists in Shanghai who would be interested to travel to Finland, especially the Kuopio region. The sport activities in Kuopio are popular so that the thesis is also about attitudes of sports tourism. The thesis is made up of two parts: the theoretical part and the empirical part. The author intr...
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Directory of Open Access Journals (Sweden)
Maliuta Iryna A.
2017-12-01
Full Text Available In the 21st century, especially in the last decade, new intercontinental integration projects appear on the global stage with a high potential for influencing the regional economic structure and at the same time bearing certain challenges for the international geo-economic and geo-political map of the world. Comprehensive new-generation inter-regional agreements are being formed, such as the TTP, the TTIP, the RCEP, the Comprehensive Economic and Trade Agreement between Canada and the EU (CETA, the Japan-EU Economic Partnership. The Asia-Pacific region has been an active participant in the creation and promotion of mega-regional trade agreements. Mega-regional trade agreements in the Asia-Pacific region, namely the TTP and the RCEP, are analyzed as mega-projects with an unprecedented scale of liberalization within the framework of the agreement that include provisions complementing the WTO framework or extending beyond it. There identified reasons for the emergence of mega-regional trade agreements and prospects for the implementation of these projects, as well as possible consequences for the international economic system. It is established that new trans-regional projects, providing certain advantages to the participating countries, simultaneously carry both opportunities and challenges for the world economy. The latter are associated with the threats of crowding the countries that do not take an active part in the integration processes out of the global chains of value creation as well as of the processes of international trade.
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Li, Le; Abutalebi, Jubin; Zou, Lijuan; Yan, Xin; Liu, Lanfang; Feng, Xiaoxia; Wang, Ruiming; Guo, Taomei; Ding, Guosheng
2015-05-01
Previous neuroimaging studies have revealed that bilingualism induces both structural and functional neuroplasticity in the dorsal anterior cingulate cortex (dACC) and the left caudate nucleus (LCN), both of which are associated with cognitive control. Since these "control" regions should work together with other language regions during language processing, we hypothesized that bilingualism may also alter the functional interaction between the dACC/LCN and language regions. Here we tested this hypothesis by exploring the functional connectivity (FC) in bimodal bilinguals and monolinguals using functional MRI when they either performed a picture naming task with spoken language or were in resting state. We found that for bimodal bilinguals who use spoken and sign languages, the FC of the dACC with regions involved in spoken language (e.g. the left superior temporal gyrus) was stronger in performing the task, but weaker in the resting state as compared to monolinguals. For the LCN, its intrinsic FC with sign language regions including the left inferior temporo-occipital part and right inferior and superior parietal lobules was increased in the bilinguals. These results demonstrate that bilingual experience may alter the brain functional interaction between "control" regions and "language" regions. For different control regions, the FC alters in different ways. The findings also deepen our understanding of the functional roles of the dACC and LCN in language processing. Copyright © 2015 Elsevier Ltd. All rights reserved.
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Regional innovation systems in Portugal: a critical evaluation
Directory of Open Access Journals (Sweden)
Domingos Santos
2014-01-01
Full Text Available La innovación ha pasado a primer plano en la política regional en las tres últimas décadas. Las políticas públicas han sido diseñadas por los «modelos de mejores prácticas» derivadas de las zonas urbano-metropolitanas de alta tecnología y regiones exitosas. Sin embargo, las lecciones aprendidas de estos ejemplos son raramente transferibles a otras partes. Los sistemas regionales de innovación en las regiones periféricas, y la posibilidad de su actuación como instrumentos de competitividad territorial, rara vez han sido objeto de discusión. El objetivo principal del artículo es, precisamente, tener a Portugal como un ejemplo para enriquecer este análisis. En la primera parte de este artículo se examina el concepto de sistemas de innovación regional en el contexto de las modernas teorías de la innovación y de las políticas regionales. Se argumenta que el papel del aprendizaje localizado es de importancia estratégica en la promoción del desarrollo regional endógeno. Luego, los autores discuten las barreras estructurales y oportunidades para promover estrategias regionales de innovación en el contexto político, económico y social portugués, y, por último, se señalan algunas especificidades que deben ser abordadas en el rediseño de las intervenciones públicas con el fin de mejorar la competitividad regional y la sostenibilidad.
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DYNAMICS ECONOMIC DISPARITIES IN NORTH-WEST REGION OF ROMANIA
Directory of Open Access Journals (Sweden)
Florea Adrian
2011-07-01
Full Text Available Even though over the years has enjoyed wide media coverage, with highlighted aspects, discrepancies and inequalities of economic potential between different regions of the world, or even parts of the same countries always remained topical. Difficulties arising from these differences were always felt, extremely painful by humans. Analyzing distinctly, participation of each county to the GDP of the Northwest Region and the composition of all indicators, we can identify significant discrepancies between counties, regions and municipalities. This is one of the reasons that led us trying to identify the causes that generated the current situation. From the perspective of the contribution of each county in the Northwest Region to Region's domestic product composition, the first place is taken by Cluj county 32.3%, followed by Bihor with 24.3%, Maramures, with 14.9% Satu-Mare, 12.1%, Bistrita-Nasaud, 9.1% and 7.2% Salaj. Consulting of the Regional Operational Programme 2007-2013 indicates that the poorest areas in the Northwest Region are in Maramures and Bistrita-Nasaud. An important part of the active population of North-West Region was employed in public enterprises and an increase of unemployment in the counties of Salaj, Satu Mare and Maramures became predictable, imminent amid restructuring of public enterprises with losses. Studies of employed population by sectors of the economy, shows a high rate of population employed in services in the counties of Cluj and Bihor and high employment in agriculture on other four counties. In a modern market economy, services are most concentrated labors, and how the workforce is distributed in the Northwest region also shows an imbalance. How Northwest Region is participating in international economic cycle has major effects on the population's living standards. Relevant for the inter-district disparities analysis is the human and agents behavior analysis and the savings and loan relationships. How people
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MacDonald, I. R.; Asper, V.; Garcia, O. P.; Kastner, M.; Leifer, I.; Naehr, T.; Solomon, E.; Yvon-Lewis, S.; Zimmer, B.
2008-12-01
HyFlux - Part I: Regional modeling of methane flux from near-seafloor gas hydrate deposits on continental margins MacDonald, I.R., Asper, V., Garcia, O., Kastner, M., Leifer, I., Naehr, T.H., Solomon, E., Yvon-Lewis, S., and Zimmer, B. The Dept. of Energy National Energy Technology Laboratory (DOE/NETL) has recently awarded a project entitled HyFlux: "Remote sensing and sea-truth measurements of methane flux to the atmosphere." The project will address this problem with a combined effort of satellite remote sensing and data collection at proven sites in the Gulf of Mexico where gas hydrate releases gas to the water column. Submarine gas hydrate is a large pool of greenhouse gas that may interact with the atmosphere over geologic time to affect climate cycles. In the near term, the magnitude of methane reaching the atmosphere from gas hydrate on continental margins is poorly known because 1) gas hydrate is exposed to metastable oceanic conditions in shallow, dispersed deposits that are poorly imaged by standard geophysical techniques and 2) the consumption of methane in marine sediments and in the water column is subject to uncertainty. The northern GOM is a prolific hydrocarbon province where rapid migration of oil, gases, and brines from deep subsurface petroleum reservoirs occurs through faults generated by salt tectonics. Focused expulsion of hydrocarbons is manifested at the seafloor by gas vents, gas hydrates, oil seeps, chemosynthetic biological communities, and mud volcanoes. Where hydrocarbon seeps occur in depths below the hydrate stability zone (~500m), rapid flux of gas will feed shallow deposits of gas hydrate that potentially interact with water column temperature changes; oil released from seeps forms sea-surface features that can be detected in remote-sensing images. The regional phase of the project will quantify verifiable sources of methane (and oil) the Gulf of Mexico continental margin and selected margins (e.g. Pakistan Margin, South China Sea
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Study of the central region of the ternary diagram Zr-Nb-Fe, Part II
International Nuclear Information System (INIS)
Ramos, C; Saragovi, C; Arias, D; Granovsky, M
2004-01-01
This work continues with the identification and characterization of the intermetallic phases and of the two-phase and three-phase fields associated with the central region of the Zr-Nb-Fe phase diagram. In order to more precisely define the two-phase field βZr + λ 2 and to specify the range of existence in the zone with the highest Fe content for the λ2 phase, new alloys were smelted with the following nominal compositions: Zr 55 Nb 35 Fe 10 and Zr 35 Nb 5 Fe 60 . These alloys were submitted to a thermal treatment at 900 o C for 4 months. The techniques used to identify and characterize the phases in the samples were: optic metallography and electronic sweep, x-ray diffraction and Mossbauer spectroscopy. An isothermic cut of the central region for the Zr-Nb-Fe diagram is proposed considering previous results and those obtained in this work (Cw)
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Coastal pollution emergency plan. Part I
Energy Technology Data Exchange (ETDEWEB)
Semanov, G.; Volkov, V.; Somkin, V.; Iljushenko-Krylov, D.
1997-12-31
A higher degree of ecological safety in ship traffic depends on onboard measures as well as reception facilities on shore, treatment of ship generated wastes and preparedness for combating emergency oil spills. The problem is particularly acute in the North Sea Route (NSR) due to high vulnerability of the Arctic ecosystems, low rates of natural degradation of oil, absence of forward coastal infrastructure, low efficiency of oil combating means in ice conditions and severe climatic conditions. Oil spills in the NSR are likely to occur as the offshore production and transportation of oil increase. Therefore a regional Oil Spill Contingency Plan (OSCP) is being constructed and developed on 3 levels: 1) Development of concept, definition of response organisations and their technical ability (Part I). 2) Collection and analysis of information, development of scenarios of probable oil spills, clearing of the funding mechanism and basis for additional outside co-operation from other Russian regions and circumpolar countries (part II). 3) Development of NSR OSCP (part III). The present report (part I) provides the plan concept, rescue organisations and data on types and amounts of the oil spill combating technical means and of the floating facilities available in the NSR or it`s vicinity. The concept takes into account subdivision of the Route, interaction and links between responsible organisations, realities of the Russian Arctic such as transport, communications, energy, labour resources etc. and requirements of the IMO and of the International Convention OPRC 90. According to Russian legislation implementation of combating operations at sea is the responsibility of the Maritime Pollution Control and Salvage Administration that consists of a Central Administration and basin emergency divisions situated in Murmansk and Nahodka. The body is responsible for carrying out cleaning operations at sea from installations and may be assisted by resources and means of the co
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Jamrah, Ahmad; Al-Futaisi, Ahmed; Rajmohan, Natarajan; Al-Yaroubi, Saif
2008-12-01
A study was carried out to develop a vulnerability map for Barka region in the North Batina of Oman using DRASTIC vulnerability index method in GIS environment. DRASTIC layers were created using data from published reports and the seven DRASTIC layers were processed by the ArcGIS geographic information system. Finally, DRASTIC maps were created for 1995 and 2004 to understand the long-term changes in the vulnerability index. DRASTIC vulnerability maps were evaluated using groundwater quality data such as chemical and biological parameters. DRASTIC vulnerability maps of 1995 and 2004 indicate that the northern part of Barka is more vulnerable to pollution than southern part and the central part of Barka also shows high relative vulnerability which is mostly related to the high conductivity values. Moreover, the changes in water level due to high abstraction rate of groundwater reflect in the vulnerability maps and low vulnerability area is increased in the southern part during 2004 compared to 1995. Moreover, regional distribution maps of nitrate, chloride and total and fecal coliforms are well correlated with DRASTIC vulnerability maps. In contrast to this, even though DRASTIC method predicted the central part of the study region is highly vulnerable, both chemical and biological parameters show lower concentrations in this region compared to coastal belt, which is mainly due to agricultural and urban development. In Barka, urban development and agricultural activities are very high in coastal region compared to southern and central part of the study area. Hence, this study concluded that DRASTIC method is also applicable in coastal region having ubiquitous contamination sources.
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Regional Development of Eastern Slovakia
Directory of Open Access Journals (Sweden)
Monika Hergezelová
2017-08-01
Full Text Available Purpose and Originality: The aim of the work is to provide an overview of regional development in Eastern Slovakia, where are Košice and Prešov Region. The originality of the work lies in the work of enriching the SWOT analysis from the author Eve Rajčáková, which is given in the book deals with the issue of Regional development and regional policy of the European Union and Slovakia. Research question: The conditions of life of people in eastern Slovakia. Method: For writing this contribution will be used method of analysis and statistics. Knowledge on this subject have been looking on the internet and in books and sources of information publicly available. Using the data collected, we dealt with the issue of regional development in the Košice and Prešov regions. Results: The topic was the beginning focused on the overall characteristics of eastern Slovakia. Furthermore, we are at work we dealt with social and economic phenomena in both regions of eastern Slovakia. We focused on GDP, unemployment and tourism, which is in the region is widespread. Society: It is well known that there are obviously different living conditions in eastern Slovakia as in other parts of Slovakia. People are forced to, mainly because of employment, leave their region to move or commute to work to the west. The paper point out the right of this negative phenomenon that is quite visible - high unemployment. Limitations: The limits of work are limited by problems of regional development in eastern Slovakia, mainly focusing on economic and social phenomena in the society.
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Opioid Prescribing Practices of Neurosurgeons: Analysis of Medicare Part D.
Khalid, Syed I; Adogwa, Owoicho; Lilly, Daniel T; Desai, Shyam A; Vuong, Victoria D; Mehta, Ankit I; Cheng, Joseph
2018-04-01
The Centers for Disease Control have declared that the United States is amidst a continuing opioid epidemic, with drug overdose-related death tripling between 1999 and 2014. Among the 47,055 overdose-related deaths that occurred in 2014, 28,647 (60.9%) of them involved an opioid. The Part D Prescriber Public Use File, which is based on beneficiaries enrolled in the Medicare Part D prescription drug program, was used to query information on prescription drug events incurred by Medicare beneficiaries with a Part D prescription drug plan from 31 June 2014 to 30 June 2015. Only those providers with the specialty description of neurosurgeon, as reported on the provider's Part B claims, were included in this study. A total of 271,502 beneficiaries, accounting for 971,581 claims and 22,152,689 day supplies of medication, accounted for the $52,956,428.40 paid by the Centers for Medicare and Medicaid Services for medication that the 4085 neurosurgeons submitted to the Centers for Medicare and Medicaid Services Part D program in the 2014 calendar year. During the same year, 402,767 (41.45%) claims for 158,749 (58.47%) beneficiaries accounted for 6,458,624 (29.16%) of the day supplies of medications and $13,962,630.11 (26.37%) of the total money spent by the Centers for Medicare and Medicaid Services Part D that year. Nationwide, the ratio of opioid claims to total Medicare Part D beneficiaries was 1.48. No statistically significant regional differences were found. The opioid misuse epidemic is a complex and national issue with patterns of prescription not significantly different between regions. All neurosurgeons must be cognizant of their prescribing practices so as to best support the resolution of this public health crisis. Copyright © 2017. Published by Elsevier Inc.
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Allen, Frank B.; And Others
This is part two of a two-part SMSG mathematics text for high school students. Chapter topics include: (1) perpendicular lines and planes in space; (2) parallel lines in a plane; (3) parallel lines in space; (4) areas of polygonal regions: (5) similarity; (6) circles and spheres; (7) constructions; (8) the area of a circle and related topics; and…
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Metadata Harvesting in Regional Digital Libraries in the PIONIER Network
Mazurek, Cezary; Stroinski, Maciej; Werla, Marcin; Weglarz, Jan
2006-01-01
Purpose: The paper aims to present the concept of the functionality of metadata harvesting for regional digital libraries, based on the OAI-PMH protocol. This functionality is a part of regional digital libraries platform created in Poland. The platform was required to reach one of main objectives of the Polish PIONIER Programme--to enrich the…
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International Nuclear Information System (INIS)
Al-Jenaid, S.S.; Mohammed, W.
2008-01-01
The aim of this study is to assess the ecological characteristics of El-Daba'a area in Egypt using GIS as a first step for the development of an environmental management plan for the area. The absence of environmental planning in the process of land use development may cause many significant negative impacts on biodiversity, ecological value and the general environmental conditions and the therefore reducing such negative impacts will improve land use development. The first part of sequel of two papers, which is a part of a sustainable land use development research program, aims at designing a spatial framework to improve land use planning and development in an environmental context. The research program deals with the problem of land use planning and development in an arid coastal area under environmentally sensitive conditions. The study area is El-Daba'a region, located in the northwestern coast of Egypt, which can be described as a wild area. The approach used in this paper consists of studying the spatial ecological characteristics of El-Daba'a region using different spatial data including maps and land sat remote sensing data. These data are used to create a series of superimposed informative layers managed by a geographic information system (GIS) to describe the spatial ecological characteristics of the study area. The developed GIS allow decision makers to handle large amounts of information simultaneously such as geology, geomorphology, land cover, wild life and many other different information layers. The system is designed to help decision makers to organize, relate, analyze and visualize the ecological data and information in the study area. The developed GIS system might be used to determine the probable effects of building a nuclear power station on the ecosystem. (author)
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Il SIT della Regione Puglia, uno strumento a beneficio dei comuni e degli enti locali della Regione
Directory of Open Access Journals (Sweden)
Valeria De Vecchi
2009-03-01
Full Text Available Puglia region's GIS: a tool in behalf of local public organizationsInnovaPuglia, together with ESRI Italia and Sinergis as technological partners, set up a Geographic Information Systemfor the italian Puglia region. It will help this public organization to better plan and manage the land and the environment of that part of Italy. The possibility to share land informations is one of the mail features of the system: this will be extremely helpful for the government activities and to fullfill land knowledge with precise and homogeneous data.
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Report on state of the environment of the Trencin region to 2002
International Nuclear Information System (INIS)
Proksa, P.; Rolkova, M.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Novacky, K.; Slamkova, M.; Vaculcikova, B.; Merka, M.
2003-01-01
The report on state of environment of the Trencin region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care
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Report on state of the environment of the Bratislava region to 2002
International Nuclear Information System (INIS)
Proksa, P.; Rolkova, M.; Tvrdon, M.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Hanzel, L.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Rostannska, Z.; Merka, M.
2003-01-01
he report on state of environment of the Bratislava region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care
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Report on state of the environment of the Trnava region to 2002
International Nuclear Information System (INIS)
Proksa, P.; Rolkova, M.; Hlavata, K.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Halabrinova, K.; Hornanova, T.; Hyrrossova, K.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Lazorissak, V.; Malik, J.; Psenakova, I.; Sekova, E.; Stevicova, L.; Vagasky, V.
2003-01-01
The report on state of environment of the Nitra region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care
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Report on state of the environment of the Kosice region to 2002
International Nuclear Information System (INIS)
Proksa, P.; Rolkova, M.; Gehinova, B.; Dzurdzenik, J.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bodova, E.; Bohus, P.; Bracinikova, J.; Bysicka, L.; Dugasova, J.; Gajdos, L.; Gazarek, G.; Goryczkova, A.; Hajnikova, M.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Kliment, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Matecek, L.; Palgutova, N.; Vagasky, V.; Bysicka, L.; Hajduova, J.; Mierka, M.; Prievoznik, J.
2003-01-01
The report on state of environment of the Kosice region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care
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Report on state of the environment of the Nitra region to 2002
International Nuclear Information System (INIS)
Proksa, P.; Rolkova, M.; Hlavata, K.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Halabrinova, K.; Hornanova, T.; Hyrrossova, K.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Lazorissak, V.; Malik, J.; Psenakova, I.; Sekova, E.; Stevicova, L.; Vagasky, V.
2003-01-01
The report on state of environment of the Nitra region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care
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Report on state of the environment of the Zilina region to 2002
International Nuclear Information System (INIS)
Proksa, P.; Rolkova, M.; Adamkovicova, A.; Barciakova, E.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Gajdos, L.; Goryczkova, A.; Hajnikova, M.; Chocholova; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kosecky, J.; Kralik, A.; Lacuska, M.; Matecek, L.; Rihalova, A.; Merka, M.; Prievoznik, J.
2003-01-01
The report on state of environment of the Zilina region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care
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Report on state of the environment of the Presov region to 2002
International Nuclear Information System (INIS)
Proksa, P.; Rolkova, M.; Gajdos, L.; Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Durbakova, Z.; Goryczkova, A.; Hajnikova, M.; Hanzel, L.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Mudronova, M.; Vagasky, V.; Merka, M.
2003-01-01
The report on state of environment of the Presov region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment; Reasons and consequences of the environment; Risk factors in the environment; Environmental care
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P. Prithvi Raj, MD, FFARCS: regional anesthesia pioneer.
Nair, Lakshmi; Giesecke, Adolph
2010-04-01
At a time when regional anesthesia was a curious alternative, Dr. Raj developed techniques to improve the success of the blocks and make regional analgesia more acceptable to the average anesthesiologist. His abundant research and numerous articles, books, lectures and demonstrations on regional anesthesia and pain management have established him as a world leader in the field. He has described new blocks and new techniques of doing old blocks. He has described the mechanism of action of intravenous regional analgesia. He has improved education and training by opening pain centers across the country, each of which has offered pain fellowship opportunities. He has founded societies dedicated to research and education in regional analgesia and pain management. Regional anesthesia and pain management will forever be linked with the name of Dr. Prithvi Raj. University of Texas Southwestern Medical Center is proud to have been a part of his early development.
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Report on state of the environment of the Banska Bystrica region to 2002
International Nuclear Information System (INIS)
Adamkovicova, A.; Bebej, J.; Bodova, E.; Bohus, P.; Bracinikova, J.; Bysicka, L.; Gajdos, L.; Goryczkova, A.; Gustafikova, T.; Hajnikova, M.; Chocholova; Jancarik, A.; Jecmenova, I.; Kanianska, R.; Kapusta, P.; Knazovicka, J.; Kovalova, A.; Kralik, A.; Lacuska, M.; Marcinatova, L.; Proksa, P.; Rolkova, M.; Vagasky, V.; Rolkova, M.
2003-01-01
The report on state of environment of the Banska Bystrica region to 2002 is presented. In this report the following parts are reviewed: Basic information about region; Compositions of the environment and their protection; Nature protection and landscape management; Environmental regional classification of the environment and endangered regions; Reasons and consequences of the environment; Risk factors in the environment; Environment conservation
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Regionalizing Immigration, Health and Inequality: Iraqi Refugees in Australia
Directory of Open Access Journals (Sweden)
Lenore Manderson
2012-01-01
Full Text Available Humanitarian immigrants and refugees face multiple adjustment tasks and post-settlement support services concentrated in metropolitan areas play an important role. As part of an ongoing commitment, the Australian Government has increasingly supported resettlement in rural and regional areas of the country. Drawing on the experience of Iraqi migrants in Victoria, Australia, we examine some of the conditions that characterize regional resettlement and raise key questions for public health policy. Structural vulnerabilities and discriminations impact upon physical, mental and social wellbeing, leading to further exclusion, with negative long-term implications. The discussion throws light on the issues that migrants and refugees may encounter in other parts within Australia, but are also germane in many countries and highlight the resulting complexity for policy-making.
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Regionální značky a jejich úloha na spotřebitelském trhu potravin
ŽÁK, Martin
2017-01-01
The thesis deals with regional brands and their role in the consumer food market, where the theoretical part to the introduction explains the basic concepts related to consumer behaviour and respect for regional consumer brands. The following is an explanation of concepts such as food quality, safety and support local producers and what is imaginable about concepts of brand and regional brand. The theoretical part is further given literary review of selected regional brands in South Bohemia, ...
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You, Si-Wei; Chen, Bing-Yao; Liu, Hui-Ling; Lang, Bing; Xia, Jie-Lai; Jiao, Xi-Ying; Ju, Gong
2003-01-01
A major issue in analysis of experimental results after spinal cord injury is spontaneous functional recovery induced by remaining nerve fibers. The authors investigated the relationship between the degree of locomotor recovery and the percentage and location of the fibers that spared spinal cord transection. The spinal cords of 12 adult rats were transected at T9 with a razor blade, which often resulted in sparing of nerve fibers in the ventral spinal cord. The incompletely-transected animals were used to study the degree of spontaneous recovery of hindlimb locomotion, evaluated with the BBB rating scale, in correlation to the extent and location of the remaining fibers. Incomplete transection was found in the ventral spinal cord in 42% of the animals. The degree of locomotor recovery was highly correlated with the percentage of the remaining fibers in the ventral and ventrolateral funiculi. In one of the rats, 4.82% of remaining fibers in unilateral ventrolateral funiculus were able to sustain a certain recovery of locomotion. Less than 5% of remaining ventrolateral white matter is sufficient for an unequivocal motor recovery after incomplete spinal cord injury. Therefore, for studies with spinal cord transection, the completeness of sectioning should be carefully checked before any conclusion can be reached. The fact that the degree of locomotor recovery is correlated with the percentage of remaining fibers in the ventrolateral spinal cord, exclusive of most of the descending motor tracts, may imply an essential role of propriospinal connections in the initiation of spontaneous locomotor recovery.
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Parasympathetic preganglionic cardiac motoneurons labeled after voluntary diving
Directory of Open Access Journals (Sweden)
W Michael ePanneton
2014-01-01
Full Text Available A dramatic bradycardia is induced by underwater submersion in vertebrates. The location of parasympathetic preganglionic cardiac motor neurons driving this aspect of the diving response was investigated using cFos immunohistochemistry combined with retrograde transport of cholera toxin subunit B (CTB to double-label neurons. After pericardial injections of CTB, trained rats voluntarily dove underwater, and their heart rates dropped immediately to 95±2bpm, an 80% reduction. After immunohistochemical processing, the vast majority of CTB labeled neurons were located in the reticular formation from the rostral cervical spinal cord to the facial motor nucleus, confirming previous studies. Labeled neurons caudal to the rostral ventrolateral medulla were usually spindle-shaped aligned along an oblique line running from the dorsal vagal nucleus to the ventrolateral reticular formation, while those more rostrally were multipolar with extended dendrites. Nine percent of retrogradely-labeled neurons were positive for both cFos and CTB after diving and 74% of these were found rostral to the obex. CTB also was transported transganglionically in primary afferent fibers, resulting in large granular deposits in dorsolateral, ventrolateral, and commissural subnuclei of the nucleus tractus solitarii and finer deposits in lamina I and IV-V of the trigeminocervical complex. The overlap of parasympathetic preganglionic cardiac motor neurons activated by diving with those activated by baro- and chemoreceptors in the rostral ventrolateral medulla is discussed. Thus the profound bradycardia seen with underwater submersion reinforces the notion that the mammalian diving response is the most powerful autonomic reflex known.
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Lopes, L T; Biancardi, V; Vieira, E B; Leite-Panissi, C; Bícego, K C; Gargaglioni, L H
2014-07-01
Although periaqueductal grey matter activation is known to elicit respiratory and cardiovascular responses, the role of this midbrain area in the compensatory responses to hypoxia is still unknown. To test the participation of the periaqueductal grey matter in cardiorespiratory and thermal responses to hypoxia in adult male Wistar rats, we performed a chemical lesion of the dorsolateral/dorsomedial or the ventrolateral/lateral periaqueductal grey matter using ibotenic acid. Pulmonary ventilation, mean arterial pressure, heart rate and body temperature were measured in unanaesthetized rats during normoxic and hypoxic exposure (5, 15, 30 min, 7% O2). An ibotenic acid lesion of the dorsolateral/dorsomedial periaqueductal grey matter caused a higher increase in pulmonary ventilation (67.1%, 1730±282.5 mL kg(-1) min(-1)) compared to the Sham group (991.4±194 mL kg(-1) min(-1)) after 15 min in hypoxia, whereas for the ventrolateral/Lateral periaqueductal grey matter lesion, no differences were observed between groups. Mean arterial pressure, heart rate and body temperature were not affected by a dorsolateral/dorsomedial or ventrolateral/lateral periaqueductal grey matter lesion. Middle to caudal portions of the dorsolateral/dorsomedial periaqueductal grey matter neurones modulate the hypoxic ventilatory response, exerting an inhibitory modulation during low O2 situations. In addition, the middle to caudal portions of the dorsolateral/dorsomedial or ventrolateral/lateral periaqueductal grey matter do not appear to exert a tonic role on cardiovascular or thermal parameters during normoxic and hypoxic conditions. © 2014 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.
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Local and regional low carbon scenarios methodology, challenges and opportunities
International Nuclear Information System (INIS)
2010-01-01
In its first part, this report discusses the emergence of local climate and energy policy in Europe, the implementation of nationally imposed but regionally anchored energy scenarios (i.e. in France, the Climate Air Energy Regional Schemes or SRCAE). Then it addresses the methodological and political aspects of local and regional low emission scenarios: methodologies and typologies of energy scenarios, ways to define an appropriate emission reduction and energy consumption objective, ways to deal with emission or carbon gaps, ways to make local emission inventories, ways to gather local data, ways to deal with special emission sources, ways to assess and develop local energy efficiency and renewable energy potentials, ways to take energy sufficiency into account, and the evolution from energy autonomy to 100% renewable energy territories. The last part addresses the issues of stake holder and citizen participation in the definition of long term strategies
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Social Inclusion: Universities and Regional Development
Wilson, Bruce
2011-01-01
At a time when the OECD (2007) is advocating more local engagement for higher education institutions, this study looks at a number of community initiatives in Australia where local universities have played a key role. All were studied as part of the PASCAL Universities and Regional Engagement (PURE) project, which involves a total of 19 regions…
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Engineering Geological Conditions of the Ignalina NPP Region
International Nuclear Information System (INIS)
Buceviciute, S.
1996-01-01
During engineering geological mapping, the upper part (to 15-20 m depths) of the lithosphere was investigated at the Ignalina Nuclear Power Plant (INPP) for physical rock characteristics and recent exogenic geological processes and phenomena. The final result of engineering geological mapping was the division of the area into engineering geological regions. In this case five engineering geological regions have been distinguished. The Fig. shows a scheme of engineering geological regionalization of the area and the typical sections of the engineering geological regions. The sections show genesis, age, soil type, thickness of stratigraphic genetical complex for the rocks occurring in the zone of active effect of engineering buildings, as well as the conical strength and density of the distinguished soils. 1 fig., 1 tab
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Zhernov, Evgeny; Nehoda, Evgenia
2017-11-01
The state, regional and industry approaches to the problem of personnel training for building an innovative knowledge economy at all levels that ensures sustainable development of the region are analyzed in the article using the cases of the Kemerovo region and the coal industry. A new regional-matrix approach to the training of highly qualified personnel is proposed, which allows to link the training systems with the regional economic matrix "natural resources - cognitive resources" developed by the author. A special feature of the new approach is the consideration of objective conditions and contradictions of regional systems of personnel training, which have formed as part of economic systems of regions differ-entiated in the matrix. The methodology of the research is based on the statement about the interconnectivity of general and local knowledge, from which the understanding of the need for a combination of regional, indus-try and state approaches to personnel training is derived. A new form of representing such a combination is the proposed approach, which is based on matrix analysis. The results of the research can be implemented in the practice of modernization of professional education of workers in the coal industry of the natural resources extractive region.
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Abnormal gray matter volume and impulsivity in young adults with Internet gaming disorder.
Lee, Deokjong; Namkoong, Kee; Lee, Junghan; Jung, Young-Chul
2017-09-08
Reduced executive control is one of the central components of model on the development and maintenance of Internet gaming disorder (IGD). Among the various executive control problems, high impulsivity has consistently been associated with IGD. We performed voxel-based morphometric analysis with diffeomorphic anatomical registration by using an exponentiated Lie algebra algorithm (DARTEL) to investigate the relationship of gray matter abnormalities to impulsivity in IGD. Thirty-one young male adults whose excessive Internet gaming began in early adolescence, and 30 age-matched male healthy controls were examined. IGD subjects showed smaller gray matter volume (GMV) in brain regions implicated in executive control, such as the anterior cingulate cortex and the supplementary motor area. The GMVs in the anterior cingulate cortex and the supplementary motor area were negatively correlated with self-reporting scales of impulsiveness. IGD subjects also exhibited smaller GMV in lateral prefrontal and parietal cortices comprising the left ventrolateral prefrontal cortex and the left inferior parietal lobule when compared with healthy controls. The GMVs in the left ventrolateral prefrontal cortex were negatively correlated with lifetime usage of Internet gaming. These findings suggest that gray matter abnormalities in areas related to executive control may contribute to high impulsivity of young adults with IGD. Furthermore, alterations in the prefrontal cortex were related with long-term excessive Internet gaming during adolescence. © 2017 Society for the Study of Addiction.
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Regional meetings on energy 2008. Ile-de-France facing the energy stakes. Conference proceedings
International Nuclear Information System (INIS)
Lamy, Marie-Laure; Rocher, Philippe; Falque-Masset, Marie-Laure; Cazas, Judith; Labrousse, Muriel; Gorges, Pascale; Boulet, Sophie; Petit-Tesson, Christophe
2009-01-01
This document proposes a synthesis of the conference. It presents an assessment of the regional plan for energy management and development of local and renewable energies. The first part gives an overview of regional actions (in the Ile de France region) performed by the ADEME, or within the regional plan. The second part presents ROSE (a network for the statistical survey of energy and of greenhouse gas emissions in Ile de France) and its activity. Some remarkable actions are briefly presented: energy management by the city of Montreuil, energy management and sensitisation in a secondary school, a zero-energy building (a school in Limeil-Brevannes), geothermal energy in Orly, solar energy in social dwelling, and wood-heat network in Cergy-Pontoise
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International Nuclear Information System (INIS)
2007-01-01
Motivated by new energetic constraints and the interest of biomass, the authors report a bibliographical survey of studies concerning the evaluation of the available forest biomass. They comment the geographical and time distribution of the identified and compiled studies. They analyse their different topics. Then, they discuss the various field hypotheses, discuss and comments various resource assessment methodologies. They comment the resource the French forest can be, present a synthesis of the available resource at the regional level according to the different studies. They propose a review of some technical-economical aspects (costs, energy cost, price evolutions, improvement of the wood-energy mobilization). The second part proposes a whole set of volume calculations for different forest types (clusters or plantations of trees, copses, sawmills products), for industry and household consumption. It discusses the available volumes with respect to accessibility, additional available volumes, and possible improvements. The third part analyses, comments and discusses the wood market and wood energetic uses, and the possible supply curves for wood energetic uses by 2016
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The gross anatomy of the male reproductive system of the European hedgehog (Erinaceus Europaeus).
Akbari, G; Babaei, M; Kianifard, D; Mohebi, D
2018-01-01
Hedgehogs are small spiny-coated insectivores. Due to their low body weight, calm character, and easy maintenance, they are kept as pets. It is therefore worthwhile to care about hedgehogs' health problems and to provide pet owners with information about their reproduction. Moreover, it is necessary to be familiar with their anatomy so as to satisfy the need to improve nutrition and medical care, even surgery. This study was carried out on five adult male European hedgehogs euthanased in a chloroform chamber. The European hedgehog's oval testes are invisible in inguinal region because they have no true scrotal sac. The testes are located in the craniocaudal direction with dorsolateral epididymal attachments. The vesicular glands, the European hedgehog's largest accessory sex glands, are lobulated structures containing dorsomedial and ventrolateral parts on each side. The prostate is an oval gland with right and left lobes. The paired bulbourethral glands are laid on the ischiocavernosus muscle. Histologically the vesicular, prostate gland ducts and ductus deferens as well as urethra separately were discharged in a diverticlum at the level of the pelvic urethra end. A sigmoid flexure exists in the proximal part of shaft body of the penis. There are two retractor penile muscles. In dorsal end of the penile glans, there is a small urethral process with two nail- -like, needle-shaped structures. They are on both sides of the urethral process. Furthermore, there are two intromittent sacs (Sacculus urethralis) in the ventral part of the end of the penis. (Folia Morphol 2018; 77, 1: 36-43).
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MODERNIZATION OF NATIONAL ECONOMY THROUGH DEVELOPMENT OF REGIONAL PRODUCTION INFRASTRUCTURE
Directory of Open Access Journals (Sweden)
T. G. Guilyadov
2011-01-01
Full Text Available Any region’s economy comprises production and non-production spheres which are interconnected and equivalent. Key part of any regional production sphere is its production infrastructure whose value is double: it defines the level of regional economic development on one hand, andinterrelation with the whole national economy on the other hand. The greatest and most important regional production infrastructure elements are transportation infrastructure, information/communication infrastructure and communal infrastructure. Analysis and solution of issues related to development of the basic regional production infrastructure elements as suggested in the article will be very useful for modernization of the national economy.
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The importance of foreign direct investments in Sumadija and Pomoravlje region
Directory of Open Access Journals (Sweden)
Đorđević Ivan
2015-01-01
Full Text Available The terms of foreign investment and foreign direct investments are very often terms in foreign economics policy because they represent one of the key issues in foreign economics and practice. The relationship between investments and economic growth is the key question in the modern economic theory. Foreign direct investments are representing the most common shape of international capital movement wich are including the long term connections between more differents countries, regions. The Sumadija and Pomoravlje Region is located in the central Part of Serbia. This Region is the heart of Serbia. Economic development of this part of Serbia is important for the economic development of the whole Serbia as a country. It is very important for the longrange economic growth to define strategy for economic growth for the region of Sumadija and Pomoravlje. In this strategy we will determine the most important tasks and objectives of economic growth also the incentives in the ten year period to come. In the transition country which is Serbia with huge regional and economical problems, without its own funds it is important to attract foreign investment, first of all direct investment. Foreign direct investment which are the basics of all investments in Serbia especially in Shumadija and Pomoravlje region.
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Ecosystem Services and Border Regions. Case Study from Czech – Polish Borderland
Directory of Open Access Journals (Sweden)
Marcin Spyra
2014-05-01
Full Text Available Land-use management and planning of cross-border regions is a complex problem. Different legislatures, development visions and interests on both sides of the border make it even more complicated. Introducing ecosystem services concept into land-use planning and management at cross-border regions is a challenge. However not much is said about this issue in literature.This paper aims to present result of the study concerning to ecosystem services concept in the context of cross-border part of Pradziad Euroregion. The studyed area is situated within Czech – Polish borderland. First part of the research concerns to land-cover analyze of the region. The second one to Czech and Polish land-use strategies, which are binding at NUTS 4 and 5 level in the studyed area.Resoults of the research indicates asymmetry of the cross-border landscape of the analyzed region. The asymmetry is indicated by different types, biodiversities and areas of ecosystems identified on both sides of the border. It is also identified by differences in land-use strategies concerning to the region.It is discussed to what extend ecosystem services concept can be implemented in planning legislature of the cross-border region.
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Regionální dostupnost sociálních služeb z geografického hlediska
Srnová, Zdeňka
2012-01-01
The goal of this elaboration is to analyze and chart the accessibility of social services in each region of Czech Republic. In the first part are described basic concepts of social services and financing of these services. The second part of this thesis deals with economic and demographic characteristics of regions of Czech Republic. The third, analytical part, is examined structure of social services and her development. Constituent part is time development of indicators, that affect accessi...
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Public information - Northwest region of Russian Federation
International Nuclear Information System (INIS)
Saiapina, A.
2001-01-01
Regional Center of Public Information in Northwest region of Russian Federation is a part of the State Regional Educational Center of Ministry of the Russian Federation for atomic energy in St.-Petersburg, Russia (http://graph.runnet.ru/). This Center of Public Information (CPI) provides a wide range of information dealing with the nuclear power. The objectives of the CPI are: to conduct informational and educational activities so as to form a positive attitude toward atomic energy and nuclear technologies; to provide the population with a means reliable information about objects of potential risk; to organize an active exchange of the information with enterprises using nuclear technologies in the region. The main topics of informational support are these: electricity production, the ground of nuclear power, new Russian nuclear reactors, nuclear safety, nuclear power and environment, radioactivity, Leningrad nuclear power plant, responsibilities in nuclear engineering. (author)
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Neural mechanisms of proactive interference-resolution.
Nee, Derek Evan; Jonides, John; Berman, Marc G
2007-12-01
The ability to mitigate interference from information that was previously relevant, but is no longer relevant, is central to successful cognition. Several studies have implicated left ventrolateral prefrontal cortex (VLPFC) as a region tied to this ability, but it is unclear whether this result generalizes across different tasks. In addition, it has been suggested that left anterior prefrontal cortex (APFC) also plays a role in proactive interference-resolution although support for this claim has been limited. The present study used event-related functional magnetic resonance imaging (fMRI) to investigate the role of these regions in resolving proactive-interference across two different tasks performed on the same subjects. Results indicate that both left VLPFC and left APFC are involved in the resolution of proactive interference across tasks. However, different functional networks related to each region suggest dissociable roles for the two regions. Additionally, regions of the posterior cingulate gyrus demonstrated unique involvement in facilitation when short- and long-term memory converged. This pattern of results serves to further specify models of proactive interference-resolution.
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Energy Technology Data Exchange (ETDEWEB)
Merry, P.A.; Luner, C.; Hong, S.W.; Canham, H.O.; Boggs, J.F.; McCool, T.P.
1976-12-01
This report is one of many supporting documents used by the Nuclear Regulatory commission in the preparation of the Nuclear Energy Center Site Survey (NECSS) mandated by Congress. While the overall study focuses on the feasibility and practicability of nuclear energy centers (NECs), this report is directed towards choosing a suitable surrogate site in the upper St. Lawrence region of New York State, assessing the probable impacts associated with construction and operation of the NEC, and comparing these impacts with those associated with small dispersed nuclear power stations. The upper St. Lawrence region is surveyed to identify a specific site that might be suitable for a surrogate NEC. Several assumptions about the basic design of an NEC are delineated, and a general overview of the characteristics of the region is given. The Fort Drum Military Reservation is chosen as a suitable surrogate site. Fort Drum and the surrounding area are described in terms of land use and population patterns, terrestrial and aquatic ecology, water use and quality, meteorology, institutional framework, and socioeconomic structure. The impacts associated with NEC development are assessed. Then the impacts associated with smaller dispersed nuclear power stations located throughout New York State are assessed and compared with the impacts associated with the NEC. Finally, the impacts due to development of the transmission line networks associated with the NEC and with the dispersed power stations are assessed and compared.
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Public information - North West region of Russian Federation
International Nuclear Information System (INIS)
Saiapina, A.
2000-01-01
Center of Public Information (CPI) in North West region of Russian Federation is a part of the State Regional Educational Center of Ministry of the Russian Federation on atomic energy. The premises of the Centre (about 500 sq. rn.) include the exposition hall, video hall, the hall for press conferences, rooms for meetings, conferences. CPI provides the visitor with the wide range of information dealing with the nuclear power. It was opened in the structure of State Regional Educational Centre in 1997. Regional Centre of Public Information of MINATOM of Russia in Saint Petersburg was created according to the agreement with the European Union Commission in the framework of the TACIS program with the participation of French companies EDF, COGEMA, STEPFER. The objectives of the CPI are discussed (authors)
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Seghedi, Ioan; Maţenco, Liviu; Downes, Hilary; Mason, Paul R. D.; Szakács, Alexandru; Pécskay, Zoltán
2011-04-01
The south-eastern part of the Carpathian-Pannonian region records the cessation of convergence between the European platform/Moesia and the Tisza-Dacia microplate. Plio-Quaternary magmatic activity in this area, in close proximity to the 'Vrancea zone', shows a shift from normal calc-alkaline to much more diverse compositions (adakite-like calc-alkaline, K-alkalic, mafic Na-alkalic and ultrapotassic), suggesting a significant change in geodynamic processes at approximately 3 Ma. We review the tectonic setting, timing, petrology and geochemistry of the post-collisional volcanism to constrain the role of orogenic building processes such as subduction or collision on melt production and migration. The calc-alkaline volcanism (5.3-3.9 Ma) marks the end of normal subduction-related magmatism along the post-collisional Călimani-Gurghiu-Harghita volcanic chain in front of the European convergent plate margin. At ca. 3 Ma in South Harghita magma compositions changed to adakite-like calc-alkaline and continued until recent times (< 0.03 Ma) interrupted at 1.6-1.2 Ma by generation of Na and K-alkalic magmas, signifying changes in the source and melting mechanism. We attribute the changes in magma composition in front of the Moesian platform to two main geodynamic events: (1) slab-pull and steepening with opening of a tear window (adakite-like calc-alkaline magmas) and (2) renewed contraction associated with deep mantle processes such as slab steepening during post-collisional times (Na and K-alkalic magmas). Contemporaneous post-collisional volcanism at the eastern edge of the Pannonian Basin at 2.6-1.3 Ma was dominated by Na-alkalic and ultrapotassic magmas, suggesting a close relationship with thermal asthenospheric doming and strain partitioning related to the Adriatic indentation. Similar timing, magma chamber processes and volume for K-alkalic (shoshonitic) magmas in the South Apuseni Mountains (1.6 Ma) and South Harghita area at a distance of ca. 200 km imply a
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Blended Learning Citation Patterns and Publication Networks across Seven Worldwide Regions
Spring, Kristian J.; Graham, Charles R.
2017-01-01
The field of international blended learning (BL) is primed to benefit from stronger communication and collaboration. Collaboration is currently limited, and regions vary greatly in terms of citations. However, BL is growing worldwide and each region is an important part of the community. The goal of this research is to explore where the most…
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Investigating shape representation using sensitivity to part- and axis-based transformations.
Denisova, Kristina; Feldman, Jacob; Su, Xiaotao; Singh, Manish
2016-09-01
Part- and axis-based approaches organize shape representations in terms of simple parts and their spatial relationships. Shape transformations that alter qualitative part structure have been shown to be more detectable than those that preserve it. We compared sensitivity to various transformations that change quantitative properties of parts and their spatial relationships, while preserving qualitative part structure. Shape transformations involving changes in length, width, curvature, orientation and location were applied to a small part attached to a larger base of a two-part shape. Increment thresholds were estimated for each transformation using a 2IFC procedure. Thresholds were converted into common units of shape difference to enable comparisons across transformations. Higher sensitivity was consistently found for transformations involving a parameter of a single part (length, width, curvature) than those involving spatial relations between two parts (relative orientation and location), suggesting a single-part superiority effect. Moreover, sensitivity to shifts in part location - a biomechanically implausible shape transformation - was consistently poorest. The influence of region-based geometry was investigated via stereoscopic manipulation of figure and ground. Sensitivity was compared across positive parts (protrusions) and negative parts (indentations) for transformations involving a change in orientation or location. For changes in part orientation (biomechanically plausible), sensitivity was better for positive than negative parts; whereas for changes in part location (biomechanically implausible), no systematic difference was observed. Copyright © 2015 Elsevier Ltd. All rights reserved.
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TRIUMF: Regional government offers KAON operating costs
Energy Technology Data Exchange (ETDEWEB)
Anon.
1992-09-15
After a period of uncertainty, confidence in the major KAON project for the Canadian TRIUMF Laboratory in Vancouver was boosted on 28 May at a rally of about a thousand KAON supporters in downtown Vancouver when the regional government of British Columbia announced its willingness to pay part of KAON's operating costs.
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International Nuclear Information System (INIS)
2007-09-01
A first part of this report proposes an analysis of the existing supply, demand and competition for the wood pellet production sector. More precisely, it proposes a brief analysis of the European pellet market and of its operation, a study of the individual PACA market (pellet market, actors, market price and evolutions in the region), and a competitive analysis. The second part reports the study of mobilisable resources. It proposes a resource analysis (potential resource identification, analysis of the regional wood sector production, other resource usages, mobilisable resources), a market and resource synthesis, an overview of possible processes (with or without drying), and a discussion of criteria to be taken into account. The third part reports a technical-economic study for the implementation of small wood pellet production units in the region. It addresses the different possible processes, compares them in terms of social and environmental assessments, and in terms of global feasibility. It also proposes a decision-making tool which comprises criteria to be taken into account and elements of thought related to regional policy
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Energy Technology Data Exchange (ETDEWEB)
NONE
2003-07-01
The ways of the regional economic integrations are not identical and generate different repercussions on the markets and the energy industries evolution. The example of the Latin America proposes many various experiences to evaluate the stakes and the limits of each regional integrations. These limits lead to solution researches including indisputable convergencies. The first part of this document presents the genesis of these regional economic integrations experiences in Latina America, to study in the second part the energy consequences of the liberal ALENA and of the more political MERCOSUR. (A.L.B.)
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Left-right cortical asymmetries of regional cerebral blood flow during listening to words
DEFF Research Database (Denmark)
Nishizawa, Y; Olsen, T S; Larsen, B
1982-01-01
1. Regional cerebral blood flow (rCBF) was measured during rest and during listening to simple words. The xenon-133 intracarotid technique was used and results were obtained from 254 regions of seven right hemispheres and seven left hemispheres. The measurements were performed just after carotid...... of the entire hemisphere. The focal rCBF increases were localized to the superior part of the temporal regions, the prefrontal regions, the frontal eye fields, and the orbitofrontal regions. Significant asymmetries were found in particular in the superior temporal region with the left side showing a more...
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Geology of Glacier National Park and the Flathead Region, Northwestern Montana
Ross, Clyde P.
1959-01-01
This report summarizes available data on two adjacent and partly overlapping regions in northwestern Montana. The first of these is Glacier National Park plus small areas east and west of the park. The second is here called, for convenience, the Flathead region; it embraces the mountains from the southern tip of Glacier Park to latitude 48 deg north and between the Great Plains on the east and Flathead Valley on the west. The fieldwork under the direction of the writer was done in 1948, 1949, 1950, and 1951, with some work in 1952 and 1953. The two regions together include parts of the Swan, Flathead, Livingstone, and Lewis Ranges. They are drained largely by branches of the Flathead River. On the east and north, however, they are penetrated by tributaries of the Missouri River and in addition by streams that flow into Canada. Roads and highways reach the borders of the regions; but there are few roads in the regions and only two highways cross them. The principal economic value of the assemblage of mountains described in the present report is as a collecting ground for snow to furnish the water used in the surrounding lowlands and as a scenic and wildlife recreation area. A few metallic deposits and lignitic coal beds are known, but these have not proved to be important and cannot, as far as can now be judged, be expected to become so. No oil except minor seeps has yet been found, and most parts of the two regions covered do not appear geologically favorable to the presence of oil in commercial quantities. The high, Hungry Horse Dam on which construction was in progress during the fieldwork now floods part of the Flathead region and will greatly influence the future of that region. The rocks range in age from Precambrian to Recent. The thickest units belong to the Belt series of Precambrian age, and special attention was paid to them. As a result, it is clear that at least the upper part of the series shows marked lateral changes within short distances. This fact
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Evaluation of the Coordination of Zonguldak-Bartın-Karabük Region Plans
Directory of Open Access Journals (Sweden)
Sevgi GÖRMÜŞ, Mustafa ARTAR
2010-01-01
Full Text Available It is observed that industry is dominant in the decisions regarding the development of Zonguldak-Bartın-KarabükRegion in the planned development process. However, the geographic structure of the region has not allowed thedevelopment of industry. The rate of poverty and migration has increased due to unrealized industry policies. Onthe other hand, unrealized industry policies have led to the conservation of the nature and natural formations.The region has been well-known in tourism in recent years with its natural beauties.If the ecotourism is developed in Zonguldak-Bartın-Karabük Part of Western Black Sea Region with its naturalbeauties, different altitudes, water sources and forests, this part can be a trademark in preserving the biodiversityof Turkey and application of ecotourism. This region keeps its attraction for industry as well with its naturalzones having international importance and ancient coastal cities but this case increases the existingenvironmental problems. Migration and unemployment are the most important problems for the region whererural population is dense. When planned carefully, ecotourism can be a significant initiative for the region and animportant source of income for the inhabitants of the region.
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Multilateral, regional and bilateral energy trade governance
Energy Technology Data Exchange (ETDEWEB)
Leal-Arcas, Rafael; Grasso, Costantino; Rios, Juan Alemany (Queen Mary Univ. of London (United Kingdom))
2014-12-01
The current international energy trade governance system is fragmented and multi-layered. Streamlining it for greater legal cohesiveness and international political and economic cooperation would promote global energy security. The current article explores three levels of energy trade governance: multilateral, regional and bilateral. Most energy-rich countries are part of the multilateral trading system, which is institutionalized by the World Trade Organization (WTO). The article analyzes the multilateral energy trade governance system by focusing on the WTO and energy transportation issues. Regionally, the article focuses on five major regional agreements and their energy-related aspects and examines the various causes that explain the proliferation of regional trade agreements, their compatibility with WTO law, and then provides several examples of regional energy trade governance throughout the world. When it comes to bilateral energy trade governance, this article only addresses the European Union’s (EU) bilateral energy trade relations. The article explores ways in which gaps could be filled and overlaps eliminated whilst remaining true to the high-level normative framework, concentrating on those measures that would enhance EU energy security.
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Auditory Connections and Functions of Prefrontal Cortex
Directory of Open Access Journals (Sweden)
Bethany ePlakke
2014-07-01
Full Text Available The functional auditory system extends from the ears to the frontal lobes with successively more complex functions occurring as one ascends the hierarchy of the nervous system. Several areas of the frontal lobe receive afferents from both early and late auditory processing regions within the temporal lobe. Afferents from the early part of the cortical auditory system, the auditory belt cortex, which are presumed to carry information regarding auditory features of sounds, project to only a few prefrontal regions and are most dense in the ventrolateral prefrontal cortex (VLPFC. In contrast, projections from the parabelt and the rostral superior temporal gyrus (STG most likely convey more complex information and target a larger, widespread region of the prefrontal cortex. Neuronal responses reflect these anatomical projections as some prefrontal neurons exhibit responses to features in acoustic stimuli, while other neurons display task-related responses. For example, recording studies in non-human primates indicate that VLPFC is responsive to complex sounds including vocalizations and that VLPFC neurons in area 12/47 respond to sounds with similar acoustic morphology. In contrast, neuronal responses during auditory working memory involve a wider region of the prefrontal cortex. In humans, the frontal lobe is involved in auditory detection, discrimination, and working memory. Past research suggests that dorsal and ventral subregions of the prefrontal cortex process different types of information with dorsal cortex processing spatial/visual information and ventral cortex processing non-spatial/auditory information. While this is apparent in the non-human primate and in some neuroimaging studies, most research in humans indicates that specific task conditions, stimuli or previous experience may bias the recruitment of specific prefrontal regions, suggesting a more flexible role for the frontal lobe during auditory cognition.
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Auditory connections and functions of prefrontal cortex
Plakke, Bethany; Romanski, Lizabeth M.
2014-01-01
The functional auditory system extends from the ears to the frontal lobes with successively more complex functions occurring as one ascends the hierarchy of the nervous system. Several areas of the frontal lobe receive afferents from both early and late auditory processing regions within the temporal lobe. Afferents from the early part of the cortical auditory system, the auditory belt cortex, which are presumed to carry information regarding auditory features of sounds, project to only a few prefrontal regions and are most dense in the ventrolateral prefrontal cortex (VLPFC). In contrast, projections from the parabelt and the rostral superior temporal gyrus (STG) most likely convey more complex information and target a larger, widespread region of the prefrontal cortex. Neuronal responses reflect these anatomical projections as some prefrontal neurons exhibit responses to features in acoustic stimuli, while other neurons display task-related responses. For example, recording studies in non-human primates indicate that VLPFC is responsive to complex sounds including vocalizations and that VLPFC neurons in area 12/47 respond to sounds with similar acoustic morphology. In contrast, neuronal responses during auditory working memory involve a wider region of the prefrontal cortex. In humans, the frontal lobe is involved in auditory detection, discrimination, and working memory. Past research suggests that dorsal and ventral subregions of the prefrontal cortex process different types of information with dorsal cortex processing spatial/visual information and ventral cortex processing non-spatial/auditory information. While this is apparent in the non-human primate and in some neuroimaging studies, most research in humans indicates that specific task conditions, stimuli or previous experience may bias the recruitment of specific prefrontal regions, suggesting a more flexible role for the frontal lobe during auditory cognition. PMID:25100931
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REGIONAL BINNING FOR CONTINUED STORAGE OF SPENT NUCLEAR FUEL AND HIGH-LEVEL WASTES
Energy Technology Data Exchange (ETDEWEB)
W. Lee Poe, Jr
1998-10-01
divided into Part 1 that defines time-dependent releases from each regional site, Part 2 that defines transport conditions through the groundwater, and Part 3 that defines transport through surface water and populations using the surface waters for drinking.
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REGIONAL BINNING FOR CONTINUED STORAGE OF SPENT NUCLEAR FUEL AND HIGH-LEVEL WASTES
International Nuclear Information System (INIS)
W. Lee Poe, Jr.
1998-01-01
divided into Part 1 that defines time-dependent releases from each regional site, Part 2 that defines transport conditions through the groundwater, and Part 3 that defines transport through surface water and populations using the surface waters for drinking
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Energy Technology Data Exchange (ETDEWEB)
Straszak, A; Owsinski, J W [Systems Research Institute, Polish Academy of Sciences, Warsaw (PL); Kairiukstis, L [Lithuanian Forest Research Institute, Kaunas, Lithuanian SSR (SU)
1989-01-01
The paper presents a systemic framework for the assessment of the current state and future development of the Baltic ecosystem as an integral part of a broader Baltic region system involving social, economic and ecological aspects. The paper formulates and adresses the following questions: with respect to what aspects is this region a system How do various systemicity reaches overlap How can be systemic behaviour rectified and /or improved, special attention being paid to inter-system synergy The focus is on the resource and ecological system of Baltic, as the potentially generative one for the other systemic structures. It is shown, though, that these other structures are not adequate to the generative one, and that this inadequacy impinges on both the economic and ecological performance. Thus, it is proposed that economic and social activities within the Baltic region should match better the variety of its resource and ecological substratum, thereby allowing smoother and more rapid development of the region and presservation of the sustainability of this devleopment. Examples range from economic cooperation and transport to tourism and recreation, and nature protection. (author).
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TRIUMF: Regional government offers KAON operating costs
International Nuclear Information System (INIS)
Anon.
1992-01-01
After a period of uncertainty, confidence in the major KAON project for the Canadian TRIUMF Laboratory in Vancouver was boosted on 28 May at a rally of about a thousand KAON supporters in downtown Vancouver when the regional government of British Columbia announced its willingness to pay part of KAON's operating costs
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Ulnar-sided wrist pain. Part I: anatomy and physical examination
International Nuclear Information System (INIS)
Vezeridis, Peter S.; Blazar, Philip; Yoshioka, Hiroshi; Han, Roger
2010-01-01
Ulnar-sided wrist pain is a common complaint, and it presents a diagnostic challenge for hand surgeons and radiologists. The complex anatomy of this region, combined with the small size of structures and subtle imaging findings, compound this problem. A thorough understanding of ulnar-sided wrist anatomy and a systematic clinical examination of this region are essential in arriving at an accurate diagnosis. In part I of this review, ulnar-sided wrist anatomy and clinical examination are discussed for a more comprehensive understanding of ulnar-sided wrist pain. (orig.)
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Molecular diagnostics of Galactic star-formation regions
Loenen, Edo; Baan, Willem; Spaans, Marco
2007-10-01
We propose a sensitive spectral survey of Galactic star-formation regions. Using the broadband correlator at two different frequencies, we expect to detect the (1-0) transition of CO, CN, HNC, HCN, HCO+, and HCO and various of their isotopes lines, as well as the (12-11) and (10-9) transitions of HC3N. The purpose of these observations is to create a consistent (public) database of molecular emission from galactic star-formation regions. The data will be interpreted using extensive physical and chemical modeling of the whole ensemble of lines, in order to get an accurate description of the molecular environment of these regions. In particular, this diagnostic approach will describe the optical depths, the densities, and the radiation fields in the medium and will allow the establishment of dominant temperature gradients. These observations are part of a program to study molecular emission on all scales, going from individual Galactic star-formation regions, through resolved nearby galaxies, to unresolved extra-galactic emission.
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THE COMPLEX NORTH TRANSITION REGION OF CENTAURUS A: RADIO STRUCTURE
Energy Technology Data Exchange (ETDEWEB)
Neff, Susan G. [NASA' s Goddard Space Flight Center, Laboratory for Observational Cosmology, Mail Code 665, Greenbelt, MD 20771 (United States); Eilek, Jean A. [Physics Department, New Mexico Tech, Socorro, NM 87801 (United States); Owen, Frazer N., E-mail: susan.g.neff@nasa.gov [National Radio Astronomy Observatory, P.O. Box O, Socorro, NM 87801 (United States)
2015-04-01
We present deep radio images of the inner ∼50 kpc of Centaurus A, taken with the Karl G. Jansky Very Large Array at 90 cm. We focus on the Transition Regions between the inner galaxy—including the active nucleus, inner radio lobes, and star-forming disk—and the outer radio lobes. We detect previously unknown extended emission around the Inner Lobes, including radio emission from the star-forming disk. We find that the radio-loud part of the North Transition Region (NTR), known as the North Middle Lobe, is significantly overpressured relative to the surrounding interstellar medium. We see no evidence for a collimated flow from the active galactic nucleus through this region. Our images show that the structure identified by Morganti et al. as a possible large-scale jet appears to be part of a narrow ridge of emission within the broader, diffuse, radio-loud region. This knotty radio ridge is coincident with other striking phenomena: compact X-ray knots, ionized gas filaments, and streams of young stars. Several short-lived phenomena in the NTR, as well as the frequent re-energization required by the Outer Lobes, suggest that energy must be flowing through both Transition Regions at the present epoch. We suggest that the energy flow is in the form of a galactic wind.
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Blumenfeld, Robert S; Nomura, Emi M; Gratton, Caterina; D'Esposito, Mark
2013-10-01
Anatomical connectivity differences between the dorsal and ventral lateral prefrontal cortex (PFC) of the non-human primate strongly suggests that these regions support different functions. However, after years of study, it remains unclear whether these regions are functionally distinct. In contrast, there has been a groundswell of recent studies providing evidence for a rostro-caudal functional organization, along the lateral as well as dorsomedial frontal cortex. Thus, it is not known whether dorsal and ventral regions of lateral PFC form distinct functional networks and how to reconcile any dorso-ventral organization with the medio-lateral and rostro-caudal axes. Here, we used resting-state connectivity data to identify parallel dorsolateral and ventrolateral streams of intrinsic connectivity with the dorsomedial frontal cortex. Moreover, we show that this connectivity follows a rostro-caudal gradient. Our results provide evidence for a novel framework for the intrinsic organization of the frontal cortex that incorporates connections between medio-lateral, dorso-ventral, and rostro-caudal axes.
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Regional stratigraphy and geologic history of Mare Crisium
Head, J. W., III; Adams, J. B.; Mccord, T. B.; Pieters, C.; Zisk, S.
1978-01-01
Remote sensing and Luna 24 sample data are used to develop a summary of the regional stratigraphy and geologic history of Mare Crisium. Laboratory spectra of Luna 24 samples, telescopic reflectance spectra in the 0.3 to 1.1 micron range and orbital X-ray data have identified three major basalt groups in the region. Group I soil is derived from iron- and magnesium-rich titaniferous basalts and was apparently emplaced over the majority of the basin, however is presently exposed as a shelf in the southwest part. Group II soils, derived from very low titanium ferrobasalts, were emplaced in two stages subsequent to Group I emplacement and now appear as part of the outer shelf and topographic annulus. Subsidence of the basin interior preceded and continued after the emplacement of the third basalt group, a soil derived from a low titanium ferrobasalt. The Luna 24 site is found to be within a patch of Group II material.
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Tectonic recherche of the central, south and sotheast regions of the peninsula
International Nuclear Information System (INIS)
Capote, R.; Goy, J.L.; Zazo, C.; Carbo, A.; Gonzalez de Vallejo, L.; Hernandez Enrile, J.L.; Urbanell, A.G.; Vegas, R.
1984-01-01
The research works done on neotectonics and its applications in the central region of the Peninsule (Central System, Tajo and Duero Tertiary Basins and Iberian Range), in the South and Southeast Regions (Provinces of Cadiz, Huelva, Almeria and Murcia) and in the Eastern Region (Province of Valencia and northern part of Alicante) are presented. In these regions, the analysis of the postmiocene tectonic is studied in the continental and coastal areas, using several different technics, from tectonic, geophysic and remote sensing methods to geomorphologic methods. (author)
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Public-Private Partnerships and Sustainable Regional Innovation Systems
DEFF Research Database (Denmark)
Lehmann, Martin; Christensen, Per; Johnson, Bjørn
-private partnerships. The role of universities if and when actively participating in ‘life outside the ivory tower’ is addressed. These partnerships are also discussed in a regional context. With point of departure in innovation theory, we combine ‘sustainable development’ with the Regional System of Innovation...... approach to propose a new concept – Sustainable Regional Innovation System – in which regional initiatives such as Public-Private(-Academic) Partnerships play an integrated role, not least in the context of ‘learning and innovation for sustainable development’. Two cases are presented to underline...... be playing in public-private partnerships for sustainable development, and the links and benefits this may provide towards universities fulfilling their first (science) and second (education) missions. In this paper, the first part is dedicated to the discussion and clarification of the concept of public...
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Il SIT della Regione Puglia, uno strumento a beneficio dei comuni e degli enti locali della Regione
Directory of Open Access Journals (Sweden)
Valeria De Vecchi
2009-03-01
for the italian Puglia region. It will help this public organization to better plan and manage the land and the environment of that part of Italy. The possibility to share land informations is one of the mail features of the system: this will be extremely helpful for the government activities and to fullfill land knowledge with precise and homogeneous data.
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The importance of a regional organism (ABACC) on the application of a modern safeguard
International Nuclear Information System (INIS)
Raffo, Ana Claudia; Palacios, Elias
1997-01-01
As an safeguards regional mechanism, the ABACC is part of Brazil-Argentina wide cooperation context. This work describes the importance of the ABACC as a control regional agency and the role played in the context of modern safeguard
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International Nuclear Information System (INIS)
Zhu Huanjun; Xu Yijun
2014-01-01
The temperature fluctuation in core outlet region of China Experimental Fast Reactor (CEFR) was numerically simulated by the CFD software Star CCM+. With the core outlet temperatures, flows etc. under rated conditions given as boundary conditions, a 1/4 region model of the reactor core outlet region was established and calculated using LES method for this problem. The analysis results show that while CEFR operates under rated conditions, the temperature fluctuation in lower part of core outlet region is mainly concentrated in area over the edge components (steel components, control rod assembly), and one in upper part is remarkable in area above all the components. The largest fluctuation amplitude is 19 K and the remarkable frequency is below 5 Hz, and it belongs to typically low frequency fluctuation. The conclusion is useful for further experimental work. (authors)
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International Nuclear Information System (INIS)
Yan-Li, Zou; Guan-Rong, Chen
2009-01-01
This paper studies pinning-controlled synchronization of complex networks with bounded or unbounded synchronized regions. To study a state-feedback pinning-controlled network with N nodes, it first converts the controlled network to an extended network of N+1 nodes without controls. It is shown that the controlled synchronizability of the given network is determined by the real part of the smallest nonzero eigenvalue of the coupling matrix of its extended network when the synchronized region is unbounded; but it is determined by the ratio of the real parts of the largest and the smallest nonzero eigenvalues of the coupling matrix when the synchronized region is bounded. Both theoretical analysis and numerical simulation show that the portion of controlled nodes has no critical values when the synchronized region is unbounded, but it has a critical value when the synchronized region is bounded. In the former case, therefore, it is possible to control the network to achieve synchronization by pinning only one node. In the latter case, the network can achieve controlled synchronization only when the portion of controlled nodes is larger than the critical value. (general)
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Urban Agglomeration and Extension in Northern Coast of West Java: A Transformation into Mega Region
Octifanny, Y.; Hudalah, D.
2017-07-01
In the past decade, at least three neighbouring metropolitan areas in the northwestern part of the island have been merging with each other: Jakarta Metropolitan Area (Jabodetabek), Bandung Metropolitan Area (Bandung Raya), and Cirebon Metropolitan Area (Ciayumajakuning). It is expected to be the first island-based mega-conurbation. This paper explores the potential emergence of mega region as a ground study, where mega region can be used for economic, logistic, transportation development. Authors use scoring analysis from economic and demographic indicators. The outcomes found a new and larger formation of city-region in the northern coast road networks (Pantura) - specifically western part of Java Island.
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Employment and Regional Inequality in Romania
Directory of Open Access Journals (Sweden)
Laura Patache
2013-08-01
Full Text Available It is no doubt that thinking about inequality plays a part in the judgments and actions of politicians, sociologists, economists and ordinary people, too. This paper examines which factors substantially influenced regional employment. Labour market, employment and unemployment have been the subject of various researches and the labour market object has been subject of dispute. Employment and unemployment are both decomposed and analyzed through separate components (such as: full employment, effective employment, atypical employment, precarious employment, regional/local employment etc., respectively, total unemployment, partial or hidden unemployment, technical and structural one and so on. The specific literature about the regional inequalities considered the income per capita as the most relevant indicator measured by Gini coefficient. Gini index measures the extent to which the distribution of income or consumption expenditure among individuals or households within an economy deviates from a perfectly equal distribution. At regional level we studied several indicators that generate regional disparities, and influence employment quality such us: employment rate, tertiary and medium employment, unemployment rate, occupied population in informal sector, employment in primary sector, rural employment, female employment. We developed a scoring based on the deviation from the average of a group of key indicators and devised a map of employment quality resulting from multi-criteria analysis.
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Teaching anti-corruption in the caucasus and black sea region(s
Directory of Open Access Journals (Sweden)
Thomas Kruessmann
2017-09-01
Full Text Available There is hardly a topic in the current transformations that is as central as corruption. Anti-corruption efforts go back to the nineties when globalisation turned the world into a corporate playing field. Since then, a wealth of tools and instruments has been invented, and any student of anti-corruption can be certain to find abundant materials. From a teacher’s perspective, turning these materials into a coherent academic subject is the first challenge. But anti-corruption is not a subject like any other. If taught properly, it should challenge every student’s moral compass and become a catalyst for the development of professional ethics. Anybody who has ever been forced to pay bribes in a university setting will remember «turning red with shame». Bribing your teacher, as compared to a traffic police or customs officer, seems like the ultimate betrayal of the notion of the intellectual community between scholar/teacher and student, and it throws into doubt the entire system of values and goals that higher education stands for. In its effect, it is as pernicious as doping in sports. And when the shame is overcome, the result will be a graduate who is «street-wise», who is ready to play the game and expect nothing less from his or her colleagues. Against this background, the purpose of this paper is twofold. It serves as a reflection on the state of anti-corruption efforts in the Black Sea and Caucasus region(s and suggests a model how electronic resources could become a catalyst in bringing blended learning/teaching on anti-corruption to the region(s. At the same time, it develops the scholarly argument that the «toolkit box approach» favoured by the United Nations Office on Drugs and Crime (UNODC is not sufficient to address the root causes of corruption in the region(s. As an alternative and to the extent that it concerns the Black Sea and Caucasus region(s, it is suggested to place anti-corruption more firmly into the context of
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Occupational injury among full-time, part-time and casual health care workers.
Alamgir, Hasanat; Yu, Shicheng; Chavoshi, Negar; Ngan, Karen
2008-08-01
Previous epidemiological studies have conflicting suggestions on the association of occupational injury risks with employment category across industries. This specific issue has not been examined for direct patient care occupations in the health care sector. To investigate whether work-related injury rates differ by employment category (part time, full time or casual) for registered nurses (RNs) in acute care and care aides (CAs) in long-term facilities. Incidents of occupational injury resulting in compensated time loss from work, over a 1-year period within three health regions in British Columbia (BC), Canada, were extracted from a standardized operational database. Detailed analysis was conducted using Poisson regression modeling. Among 8640 RNs in acute care, 37% worked full time, 24% part time and 25% casual. The overall rates of injuries were 7.4, 5.3 and 5.5 per 100 person-years, respectively. Among the 2967 CAs in long-term care, 30% worked full time, 20% part time and 40% casual. The overall rates of injuries were 25.8, 22.9 and 18.1 per 100 person-years, respectively. In multivariate models, having adjusted for age, gender, facility and health region, full-time RNs had significantly higher risk of sustaining injuries compared to part-time and casual workers. For CAs, full-time workers had significantly higher risk of sustaining injuries compared to casual workers. Full-time direct patient care occupations have greater risk of injury compared to part-time and casual workers within the health care sector.
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LLNL's Regional Seismic Discrimination Research
International Nuclear Information System (INIS)
Hanley, W; Mayeda, K; Myers, S; Pasyanos, M; Rodgers, A; Sicherman, A; Walter, W
1999-01-01
As part of the Department of Energy's research and development effort to improve the monitoring capability of the planned Comprehensive Nuclear-Test-Ban Treaty international monitoring system, Lawrence Livermore Laboratory (LLNL) is testing and calibrating regional seismic discrimination algorithms in the Middle East, North Africa and Western Former Soviet Union. The calibration process consists of a number of steps: (1) populating the database with independently identified regional events; (2) developing regional boundaries and pre-identifying severe regional phase blockage zones; (3) measuring and calibrating coda based magnitude scales; (4a) measuring regional amplitudes and making magnitude and distance amplitude corrections (MDAC); (4b) applying the DOE modified kriging methodology to MDAC results using the regionalized background model; (5) determining the thresholds of detectability of regional phases as a function of phase type and frequency; (6) evaluating regional phase discriminant performance both singly and in combination; (7) combining steps 1-6 to create a calibrated discrimination surface for each stations; (8) assessing progress and iterating. We have now developed this calibration procedure to the point where it is fairly straightforward to apply earthquake-explosion discrimination in regions with ample empirical data. Several of the steps outlined above are discussed in greater detail in other DOE papers in this volume or in recent publications. Here we emphasize the results of the above process: station correction surfaces and their improvement to discrimination results compared with simpler calibration methods. Some of the outstanding discrimination research issues involve cases in which there is little or no empirical data. For example in many cases there is no regional nuclear explosion data at IMS stations or nearby surrogates. We have taken two approaches to this problem, first finding and using mining explosion data when available, and
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Towards an integrated, multiple constraint approach. Assessing the regional carbon balance
International Nuclear Information System (INIS)
Kruijt, B.; Dolman, A.J.; Lloyd, J.; Ehleringer, J.; Raupach, M.; Finnigan, J.
2001-01-01
Full carbon accounting for regions as a whole, considering all fluxes and transports, is ultimately the only real hope if we are to manage global CO2 emissions. Many methods exist to estimate parts of the carbon budget, but none is yet available to measure carbon fluxes directly at regional scales. Atmospheric Boundary-Layer budgeting methods do have this potential. In the winter of 2000, an international workshop was held in Gubbio, Italy, to discuss ways to advance from the pilot experiments that have been carried out on these methods. First, the meeting helped to advance the methodology and clarify its objectives, requirements and merits. But more importantly, the outcome of the meeting was that atmospheric budget methods should be part of an integrative approach, in which data and model results of very different kinds and from very different scales all provide constraints for estimating the net carbon exchange of a region. Several international projects are now operating to achieve this goal
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76 FR 14284 - Domestic Shipping Services Product Launch of Parcel Select Regional Ground
2011-03-16
... POSTAL SERVICE 39 CFR Part 111 Domestic Shipping Services Product Launch of Parcel Select Regional... Standards of the United States Postal Service, Domestic Mail Manual (DMM[supreg]), to introduce a new competitive shipping option, Parcel Select Regional Ground \\TM\\ service. DATES: Effective Date: April 17, 2011...
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Genetic diversity of Phytophthora infestans in the Northern Andean region.
Cárdenas, Martha; Grajales, Alejandro; Sierra, Roberto; Rojas, Alejandro; González-Almario, Adriana; Vargas, Angela; Marín, Mauricio; Fermín, Gustavo; Lagos, Luz E; Grünwald, Niklaus J; Bernal, Adriana; Salazar, Camilo; Restrepo, Silvia
2011-02-09
Phytophthora infestans (Mont.) de Bary, the causal agent of potato late blight, is responsible for tremendous crop losses worldwide. Countries in the northern part of the Andes dedicate a large proportion of the highlands to the production of potato, and more recently, solanaceous fruits such as cape gooseberry (Physalis peruviana) and tree tomato (Solanum betaceum), all of which are hosts of this oomycete. In the Andean region, P. infestans populations have been well characterized in Ecuador and Peru, but are poorly understood in Colombia and Venezuela. To understand the P. infestans population structure in the Northern part of the Andes, four nuclear regions (ITS, Ras, β-tubulin and Avr3a) and one mitochondrial (Cox1) region were analyzed in isolates of P. infestans sampled from different hosts in Colombia and Venezuela. Low genetic diversity was found within this sample of P. infestans isolates from crops within several regions of Colombia and Venezuela, revealing the presence of clonal populations of the pathogen in this region. We detected low frequency heterozygotes, and their distribution patterns might be a consequence of a high migration rate among populations with poor effective gene flow. Consistent genetic differentiation exists among isolates from different regions. The results here suggest that in the Northern Andean region P. infestans is a clonal population with some within-clone variation. P. infestans populations in Venezuela reflect historic isolation that is being reinforced by a recent self-sufficiency of potato seeds. In summary, the P. infestans population is mainly shaped by migration and probably by the appearance of variants of key effectors such as Avr3a.
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Genetic diversity of Phytophthora infestans in the Northern Andean region
Directory of Open Access Journals (Sweden)
Grünwald Niklaus J
2011-02-01
Full Text Available Abstract Background Phytophthora infestans (Mont. de Bary, the causal agent of potato late blight, is responsible for tremendous crop losses worldwide. Countries in the northern part of the Andes dedicate a large proportion of the highlands to the production of potato, and more recently, solanaceous fruits such as cape gooseberry (Physalis peruviana and tree tomato (Solanum betaceum, all of which are hosts of this oomycete. In the Andean region, P. infestans populations have been well characterized in Ecuador and Peru, but are poorly understood in Colombia and Venezuela. To understand the P. infestans population structure in the Northern part of the Andes, four nuclear regions (ITS, Ras, β-tubulin and Avr3a and one mitochondrial (Cox1 region were analyzed in isolates of P. infestans sampled from different hosts in Colombia and Venezuela. Results Low genetic diversity was found within this sample of P. infestans isolates from crops within several regions of Colombia and Venezuela, revealing the presence of clonal populations of the pathogen in this region. We detected low frequency heterozygotes, and their distribution patterns might be a consequence of a high migration rate among populations with poor effective gene flow. Consistent genetic differentiation exists among isolates from different regions. Conclusions The results here suggest that in the Northern Andean region P. infestans is a clonal population with some within-clone variation. P. infestans populations in Venezuela reflect historic isolation that is being reinforced by a recent self-sufficiency of potato seeds. In summary, the P. infestans population is mainly shaped by migration and probably by the appearance of variants of key effectors such as Avr3a.
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DECISION MAKING IN COMPETITIVENESS OF REGIONS
Directory of Open Access Journals (Sweden)
Marija Bogataj
2011-02-01
Full Text Available ESPON ATTREG project aims to investigate the motivation and behaviour of migration flows and daily commuting of students, tourists, aging population migrating to their secondary homes, students and other “part time” commuters – but especially behaviour of human resources in gross migrations and daily commuting – between regions. One of the key elements of the cohesion policy of the European Commission is the contribution of the development of new transport infrastructure to regional economic development. Extensive spending has taken place under ERDF, Cohesion Fund and ISPA to reduce disparities among regions. One of the prominent initiatives in the European Union in this respect is the development of the Trans-European transport networks (TEN-T, where also investments in Slovenian networks took place among priority list, which is based on the accessibility index value. In the case study of Slovenia decision support system is suggested for better forecasting the results of investments.
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Sundhedskonsekvensvurdering i danske kommuner og regioner
DEFF Research Database (Denmark)
Fredsgaard, Mette Winge
2010-01-01
Cities Network towards the development and strengthening of the HIA-methodology in Denmark. The Danish Healthy Cities Network is granted money to carry out the first part of the project ‛Health impact assessment in Danish municipalities and regions’, which main objective is to increase the capacity...... of the Healthy Cities Network (HCN), 29 municipalities outside the Healthy Cities Network (non-members - NM) and the 5 regions in Denmark. Where needed, elaborating telephone conversations with the relevant public officials were performed. The survey received a response rate of 72.5 % from the municipalities...... of the Healthy Cities Network, (52), 44.8 % from non-members (13) and 100 % from the regions. The results of the survey indicate a wide knowledge of the concept of health impact assessment both by the municipalities (88.6 % for HCN and 69.2 % for NM) and the regions (100 %). On the other hand only 16 out of 98...
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Possible existence of wormholes in the central regions of halos
Energy Technology Data Exchange (ETDEWEB)
Rahaman, Farook, E-mail: rahaman@iucaa.ernet.in [Department of Mathematics, Jadavpur University, Kolkata 700032, West Bengal (India); Salucci, P., E-mail: salucci@sissa.it [SISSA, International School for Advanced Studies, Via Bonomea 265, 34136, Trieste (Italy); INFN, Sezione di Trieste, Via Valerio 2, 34127, Trieste (Italy); Kuhfittig, P.K.F., E-mail: kuhfitti@msoe.edu [Department of Mathematics, Milwaukee School of Engineering, Milwaukee, WI 53202-3109 (United States); Ray, Saibal, E-mail: saibal@iucaa.ernet.in [Department of Physics, Government College of Engineering and Ceramic Technology, Kolkata 700010, West Bengal (India); Rahaman, Mosiur, E-mail: mosiurju@gmail.com [Department of Mathematics, Meghnad Saha Institute of Technology, Kolkata 700150 (India)
2014-11-15
An earlier study (Rahaman, et al., 2014 and Kuhfittig, 2014) has demonstrated the possible existence of wormholes in the outer regions of the galactic halo, based on the Navarro–Frenk–White (NFW) density profile. This paper uses the Universal Rotation Curve (URC) dark matter model to obtain analogous results for the central parts of the halo. This result is an important compliment to the earlier result, thereby confirming the possible existence of wormholes in most of the spiral galaxies. - Highlights: • Earlier we showed possible existence of wormholes in the outer regions of halo. • We obtain here analogous results for the central parts of the galactic halo. • Our result is an important compliment to the earlier result. • This confirms possible existence of wormholes in most of the spiral galaxies.
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Energy Technology Data Exchange (ETDEWEB)
NONE
2003-07-01
The ways of the regional economic integrations are not identical and generate different repercussions on the markets and the energy industries evolution. The example of the Latin America proposes many various experiences to evaluate the stakes and the limits of each regional integrations. These limits lead to solution researches including indisputable convergencies. The first part of this document presents the genesis of these regional economic integrations experiences in Latina America, to study in the second part the energy consequences of the liberal ALENA and of the more political MERCOSUR. (A.L.B.)
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Nuclear developments in the Asia and Pacific region
International Nuclear Information System (INIS)
1990-07-01
Countries in the Asia and Pacific region are engaged in many aspects of nuclear science and technology, often as part of national development plan. A number of them are members of the Regional Cooperative Agreement for Research, Development and Training Related to Nuclear Science and Technology which was developed under the auspices of the International Atomic Energy Agency to provide a basis for nuclear technical assistance and cooperation in the Asia and Pacific region. The report describes nuclear developments, from power and research reactors to reprocessing facilities, in these countries. The information was gathered from a range of sources, including relevant journals, publications of the International Atomic Energy Agency, the OECD/ Nuclear Energy Agen, and annual reports of national nuclear institutes. 4 tabs
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Regional Test Center Operations Manual
Energy Technology Data Exchange (ETDEWEB)
Stein, Joshua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Burnham, Laurie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jones, Christian Birk [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
2017-07-01
The U.S. DOE Regional Test Center for Solar Technologies program was established to validate photovoltaic (PV) technologies installed in a range of different climates. The program is funded by the Energy Department's SunShot Initiative. The initiative seeks to make solar energy cost competitive with other forms of electricity by the end of the decade. Sandia National Laboratory currently manages four different sites across the country. The National Renewable Energy Laboratory manages a fifth site in Colorado. The entire PV portfolio currently includes 20 industry partners and almost 500 kW of installed systems. The program follows a defined process that outlines tasks, milestones, agreements, and deliverables. The process is broken out into four main parts: 1) planning and design, 2) installation, 3) operations, and 4) decommissioning. This operations manual defines the various elements of each part.
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The Regional Advisory Councils' current capacities and unforeseen benefits
DEFF Research Database (Denmark)
Ounanian, Kristen; Hegland, Troels Jacob
2012-01-01
The 2002 Common Fisheries Policy (CFP) reform introduced the Regional Advisory Councils (RACs) to enhance stakeholder involvement and correct one of the policy's primary deficiencies, its lack of legitimacy, arising in part from low stakeholder involvement. While some criticize the 2002 reform as...
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Defining the spatial scale in modern regional analysis new challenges from data at local level
Fernández Vázquez, Esteban
2014-01-01
This book discusses the concept of region, including techniques of ecological inference applied to estimating disaggregated data from observable aggregates. The final part presents applications in line with the functional areas definition in regional analysis.
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Directory of Open Access Journals (Sweden)
Chen Gang
2018-02-01
Full Text Available An efficient hybrid algorithm is proposed to analyze the electromagnetic scattering properties of an infinitely thin metal plate in the lower terahertz (THz frequency region. In this region, the metal plate can be viewed as a perfect electrically conductive object with a marginally rough surface. Hence, the THz scattered field from the metal plate can be divided into coherent and incoherent parts. The physical optics and truncated-wedge incremental-length diffraction coefficients methods are used to compute the coherent part, whereas the small perturbation method is used to compute the incoherent part. Then, the radar cross section of the rough metal plate surface is computed by the multilevel fast multipole and proposed hybrid algorithms. The numerical results show that the proposed algorithm has a good accuracy when rapidly simulating the scattering properties in the lower THz region.
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NSGIC Regional | GIS Inventory — Hospitals dataset current as of 2000. Part of Community Facilities data set for all eleven counties and twenty-two cities within Middle Georgia. Updated by MGRC and...
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Regional Assessment of Supplementation Project
International Nuclear Information System (INIS)
1991-10-01
The Fish and Wildlife Program of the Northwest Power Planning Council (NPPC) prescribes several approaches to achieve its goal of doubling the salmon and steelhead runs of the Columbia River. Among those approaches are habitat restoration, improvements in adult and juvenile passage at dams and artificial propagation. Supplementation will be a major part of the new hatchery programs. The purpose of the Regional Assessment of Supplementation Project (RASP) is to provide an overview of ongoing and planned supplementation activities, to construct a conceptual framework and model for evaluating the potential benefits and risks of supplementation and to develop a plan for better regional coordination of research and monitoring and evaluation of supplementation. RASP has completed its first year of work. Progress toward meeting the first year's objectives and recommendations for future tasks are contained in this report
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CT of the canine lumbosacral spine in extension - flexion rotation; part I: bony window
International Nuclear Information System (INIS)
Henninger, W.; Werner, G.
2002-01-01
The canine lumbosacral spine is examined radiographically in extended and flexed lateral position as well as ventrodorsally. Superimposition of bones hinders exact evaluation of the lumbosacral intervertebral foramen in case of cauda equina syndrome, especially when degenerative changes overlap. CT or MRI are more and more indicated to get reliable findings because myelography is not always of diagnostic value. For this study twelve dogs (7 German Shepherd dogs, 4 Cross-breds, and 1 Rottweiler) of different age and sex were taken which had been referred for CT examination of the lumbosacral area. Plain radiographs did not show abnormalities. The anaesthetized dogs were positioned in dorsal recumbency with the legs firstly extended and secondly flexed according to flexion-extension radiography. Slice thickness was 2 mm, the CT images were evaluated in both bony and soft tissue windows. Bony window easily showed vertebral bodies, vertebral canal, pedicles, vertebral laminae, and articular processes of L7 and S1. Median height of the vertebral canal did not change during extension or flexion at the level of L7 and the sacrum. Height and width of the intervertebral foramen and width of the interarcual foramen changed markedly from extension to flexion. Lateral recessus of the vertebral canal always could be observed as ventrolateral widening. In sagittal CT scans of the lumbosacral specimen of a normal German Shepherd dog cranial articular processes of the sacrum were detected to be responsible for maximum height or width of the intervertebral foramen. Evolving from the lateral recessus the intervertebral foramen was initially oval-shaped and got rounded and narrowed by the cranial articular process of the sacrum. Position and shape of the cranial articular processes of the sacrum were evaluated. Surface of the cranial articular processes of S1 were found even with articular spaces congruent, but some also appeared slightly concave or convex where incongruity of the
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Regional Economic Growth; Socio-Economic Disparities among Counties
Directory of Open Access Journals (Sweden)
Salih Özgür SARICA
2014-12-01
Full Text Available State level economy has always been relying on its major metropolitan area’s economic success. So, such metropolitan agglomerations have been considered the only agents that can foster the state’s economic standing as if other economic places do (or may not have significant contribution to the regional economy. In contrast, as some major cities enhance their economic well-being and agglomerate in specialized sector, the rest of the region lose their economic grounds or stay constant by widening the economic gap among cities. Therefore, an institutional approach can help to establish new regional arrangements to substitute all economic places to coordinate each other and succeed the economic growth as part of state government by reducing the disparities. In this sense, this study builds upon the inquiry that seeks the impacts of some economic disparities among economic places (counties on the performances of state level regional economy.
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Revisiting Tourism Regional Economic Impact: Accounting for Secondary Household Employment
Hughes, David W.; Shields, Martin
2007-01-01
Many argue that tourism development is beneficial for local economies, partly because of spillover effects. Others hold that tourism jobs are lower paying, often seasonal, and can generate a host of social ills with earned income concentrated in low-income households. A Social Accounting Matrix (SAM) of a Pennsylvania region is used to test the impacts of tourism businesses supported by the Progress Fund, a regional Community Development Financial Institution, on household income distribution...
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Probabilistic seismic hazard assessment of southern part of Ghana
Ahulu, Sylvanus T.; Danuor, Sylvester Kojo; Asiedu, Daniel K.
2018-05-01
This paper presents a seismic hazard map for the southern part of Ghana prepared using the probabilistic approach, and seismic hazard assessment results for six cities. The seismic hazard map was prepared for 10% probability of exceedance for peak ground acceleration in 50 years. The input parameters used for the computations of hazard were obtained using data from a catalogue that was compiled and homogenised to moment magnitude (Mw). The catalogue covered a period of over a century (1615-2009). The hazard assessment is based on the Poisson model for earthquake occurrence, and hence, dependent events were identified and removed from the catalogue. The following attenuation relations were adopted and used in this study—Allen (for south and eastern Australia), Silva et al. (for Central and eastern North America), Campbell and Bozorgnia (for worldwide active-shallow-crust regions) and Chiou and Youngs (for worldwide active-shallow-crust regions). Logic-tree formalism was used to account for possible uncertainties associated with the attenuation relationships. OpenQuake software package was used for the hazard calculation. The highest level of seismic hazard is found in the Accra and Tema seismic zones, with estimated peak ground acceleration close to 0.2 g. The level of the seismic hazard in the southern part of Ghana diminishes with distance away from the Accra/Tema region to a value of 0.05 g at a distance of about 140 km.
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Probabilistic seismic hazard assessment of southern part of Ghana
Ahulu, Sylvanus T.; Danuor, Sylvester Kojo; Asiedu, Daniel K.
2017-12-01
This paper presents a seismic hazard map for the southern part of Ghana prepared using the probabilistic approach, and seismic hazard assessment results for six cities. The seismic hazard map was prepared for 10% probability of exceedance for peak ground acceleration in 50 years. The input parameters used for the computations of hazard were obtained using data from a catalogue that was compiled and homogenised to moment magnitude (Mw). The catalogue covered a period of over a century (1615-2009). The hazard assessment is based on the Poisson model for earthquake occurrence, and hence, dependent events were identified and removed from the catalogue. The following attenuation relations were adopted and used in this study—Allen (for south and eastern Australia), Silva et al. (for Central and eastern North America), Campbell and Bozorgnia (for worldwide active-shallow-crust regions) and Chiou and Youngs (for worldwide active-shallow-crust regions). Logic-tree formalism was used to account for possible uncertainties associated with the attenuation relationships. OpenQuake software package was used for the hazard calculation. The highest level of seismic hazard is found in the Accra and Tema seismic zones, with estimated peak ground acceleration close to 0.2 g. The level of the seismic hazard in the southern part of Ghana diminishes with distance away from the Accra/Tema region to a value of 0.05 g at a distance of about 140 km.
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Directory of Open Access Journals (Sweden)
O. P. Yermolaev
2015-03-01
Full Text Available Quantitative assessments of soil loss from cultivated land and sediment redistribution along pathways from cultivated fields to river channels have been undertaken using a range of different methods and techniques, including erosion models, detailed studies of sediment redistribution in representative catchments, monitoring of gully head retreat and evaluation of sediment deposition in ponds and small reservoirs. Most of the sediment eroded from arable land is deposited between the lower portions of the cultivated slopes and the river channels. Less than 15% of the eroded sediment is delivered to the river channels. Sediment redistribution rates in the upper parts of the fluvial system have declined during the last 25 years in both the western and eastern parts of the Russian Plain, because of a major reduction of surface runoff during snowmelt and a reduction of the area of arable land in some parts of the study area.
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Causes for contemporary regional sea level changes.
Stammer, Detlef; Cazenave, Anny; Ponte, Rui M; Tamisiea, Mark E
2013-01-01
Regional sea level changes can deviate substantially from those of the global mean, can vary on a broad range of timescales, and in some regions can even lead to a reversal of long-term global mean sea level trends. The underlying causes are associated with dynamic variations in the ocean circulation as part of climate modes of variability and with an isostatic adjustment of Earth's crust to past and ongoing changes in polar ice masses and continental water storage. Relative to the coastline, sea level is also affected by processes such as earthquakes and anthropogenically induced subsidence. Present-day regional sea level changes appear to be caused primarily by natural climate variability. However, the imprint of anthropogenic effects on regional sea level-whether due to changes in the atmospheric forcing or to mass variations in the system-will grow with time as climate change progresses, and toward the end of the twenty-first century, regional sea level patterns will be a superposition of climate variability modes and natural and anthropogenically induced static sea level patterns. Attribution and predictions of ongoing and future sea level changes require an expanded and sustained climate observing system.
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Vertical landscraping, a big regionalism for Dubai.
Wilson, Matthew
2010-01-01
Dubai's ecologic and economic complications are exacerbated by six years of accelerated expansion, a fixed top-down approach to urbanism and the construction of iconic single-phase mega-projects. With recent construction delays, project cancellations and growing landscape issues, Dubai's tower typologies have been unresponsive to changing environmental, socio-cultural and economic patterns (BBC, 2009; Gillet, 2009; Lewis, 2009). In this essay, a theory of "Big Regionalism" guides an argument for an economically and ecologically linked tower typology called the Condenser. This phased "box-to-tower" typology is part of a greater Landscape Urbanist strategy called Vertical Landscraping. Within this strategy, the Condenser's role is to densify the city, facilitating the creation of ecologic voids that order the urban region. Delineating "Big Regional" principles, the Condenser provides a time-based, global-local urban growth approach that weaves Bigness into a series of urban-regional, economic and ecological relationships, builds upon the environmental performance of the city's regional architecture and planning, promotes a continuity of Dubai's urban history, and responds to its landscape issues while condensing development. These speculations permit consideration of the overlooked opportunities embedded within Dubai's mega-projects and their long-term impact on the urban morphology.
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Directory of Open Access Journals (Sweden)
Y. C. Sud
2009-10-01
Full Text Available Version-4 of the Goddard Earth Observing System (GEOS-4 General Circulation Model (GCM was employed to assess the influence of potential changes in aerosols on the regional circulation, ambient temperatures, and precipitation in four selected regions: India and Africa (current paper, as well as North and South America (companion paper. Ensemble-simulations were carried out with the GCM to assess the aerosol direct and indirect effects, hereafter ADE and AIE. Each simulation was started from the NCEP-analyzed initial conditions for 1 May and was integrated through May-June-July-August of each year: 1982–1987 to provide an ensemble set of six simulations. In the first set, called experiment (#1, climatological aerosols were prescribed. The next two experiments (#2 and #3 had two sets of simulations each: one with 2X and other with 1/2X the climatological aerosols over each of the four selected regions. In experiment #2, the anomaly regions were advectively restricted (AR, i.e., the large-scale prognostic fields outside the aerosol anomaly regions were prescribed while in experiment #3, the anomaly regions were advectively Interactive (AI as is the case in a normal GCM integrations, but with the same aerosols anomalies as in experiment #2. Intercomparisons of circulation, diabatic heating, and precipitation difference fields showed large disparities among the AR and AI simulations, which raised serious questions about the proverbial AR assumption, commonly invoked in regional climate simulation studies. Consequently AI simulation mode was chosen for the subsequent studies. Two more experiments (#4 and #5 were performed in the AI mode in which ADE and AIE were activated one at a time. The results showed that ADE and AIE work in concert to make the joint influences larger than sum of each acting alone. Moreover, the ADE and AIE influences were vastly different for the Indian and Africa regions, which suggest an imperative need to include them
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TYPES OF POLITICAL REGIMES IN THE IRKUTSK REGION
Directory of Open Access Journals (Sweden)
И В Орлова
2017-12-01
Full Text Available The authors consider contemporary western and Russian classifications of regional political regimes and their applicability for Russia. Based on the analysis of political theories, the authors chose the traditional typology of regional political regimes focusing on the minimalist interpretation of democracy (electoral competition and methods for identifying regional scenarios introduced by V.Ya. Gelman. The authors study the case of the Irkutsk Region as a region with conflicting elites, in which in a short period several regional heads were replaced. Based on the contemporary political history, the authors analyze the regional political regime using the following criteria: democracy/autocracy, consolidation/oligo-poly, compromise/conflict relations within the ruling elite. The results of the analysis prove the existence of checks and balances in the political system of the Irkutsk Region. Such a system restrains strong politicians attempts to monopolize the political power in the region. When any political player gains too much influence, other centers of power unite against him and together return the situation to the status quo. The political regime of the Irkutsk Region ensures a relatively high level of political competition, at the same time it is a part of the uncompetitive political regime of the Russian Federation, therefore it is a ‘hybrid democracy’. The authors’ analysis of intra-elite relations in the region revealed a high predisposition to conflicts with the dominant scenario of ‘war of all against all’.
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Energy Technology Data Exchange (ETDEWEB)
Bigotte, G. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires
1956-01-15
This thesis is divided in two parts: a detailed petrographical and stratigraphical study of the upper layers of calcareous schist in Congo which lead to some sedimentological considerations, and a metallogenic study of the ores of Niari basin which lead to a theoretical description of the metallogeny in Congo. In the first part, after a brief description of the methods used, a petrographical survey of the rocks of the upper layers of calcareous schist of the Boko-Congo area is given as well as sedimentological conclusions and stratigraphical data. The studies and conclusions related to this limited area are extended to a region scale. A structural study and precised descriptions of this region lead to an attempt of tectonic explanation. In the second part, an inventory and description of known mineralisation points in the Niari basin are given and in particular the detailed descriptions of four deposits: La Grande-Mine, M'Passa, Diangala and Djenguile. The interpretations and conclusions are based on the study of the general characters of the mineralisation in Niari basin and its comparison with the mineralisation in Katanga (now Shaba region) and North Rhodesia (now Zambia). (M.P.)
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Energy Technology Data Exchange (ETDEWEB)
Bigotte, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires
1956-01-15
This thesis is divided in two parts: a detailed petrographical and stratigraphical study of the upper layers of calcareous schist in Congo which lead to some sedimentological considerations, and a metallogenic study of the ores of Niari basin which lead to a theoretical description of the metallogeny in Congo. In the first part, after a brief description of the methods used, a petrographical survey of the rocks of the upper layers of calcareous schist of the Boko-Congo area is given as well as sedimentological conclusions and stratigraphical data. The studies and conclusions related to this limited area are extended to a region scale. A structural study and precised descriptions of this region lead to an attempt of tectonic explanation. In the second part, an inventory and description of known mineralisation points in the Niari basin are given and in particular the detailed descriptions of four deposits: La Grande-Mine, M'Passa, Diangala and Djenguile. The interpretations and conclusions are based on the study of the general characters of the mineralisation in Niari basin and its comparison with the mineralisation in Katanga (now Shaba region) and North Rhodesia (now Zambia). (M.P.)
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Directory of Open Access Journals (Sweden)
J. J. West
2009-08-01
Full Text Available Observations and models demonstrate that ozone and its precursors can be transported between continents and across oceans. We model the influences of 10% reductions in anthropogenic nitrogen oxide (NOx emissions from each of nine world regions on surface ozone air quality in that region and all other regions. In doing so, we quantify the relative importance of long-range transport between all source-receptor pairs, for direct short-term ozone changes. We find that for population-weighted concentrations during the three-month "ozone-season", the strongest inter-regional influences are from Europe to the Former Soviet Union, East Asia to Southeast Asia, and Europe to Africa. The largest influences per unit of NOx reduced, however, are seen for source regions in the tropics and Southern Hemisphere, which we attribute mainly to greater sensitivity to changes in NOx in the lower troposphere, and secondarily to increased vertical convection to the free troposphere in tropical regions, allowing pollutants to be transported further. Results show, for example, that NOx reductions in North America are ~20% as effective per unit NOx in reducing ozone in Europe during summer, as NOx reductions from Europe itself. Reducing anthropogenic emissions of non-methane volatile organic compounds (NMVOCs and carbon monoxide (CO by 10% in selected regions, can have as large an impact on long-range ozone transport as NOx reductions, depending on the source region. We find that for many source-receptor pairs, the season of greatest long-range influence does not coincide with the season when ozone is highest in the receptor region. Reducing NOx emissions in most source regions causes a larger decrease in export of ozone from the source region than in ozone production outside of the source region.
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The distribution of warm gas in the G327.3-0.6 star forming region
Leurini, S.; Wyrowski, F.; van der Tak, F.; Herpin, F.; Herschel WISH Team, [Unknown
Water is a key molecule for determining the physical chemical structure of star forming regions because of its large abundance variations between warm and cold regions. As a part of the HIFI-led Key Program WISH (P.I. E. van Dishoeck), we are mapping six massive star forming region in different H2O
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Conflict Resolution Trends in the Black Sea Region
Directory of Open Access Journals (Sweden)
Hanna Shelest
2012-01-01
Full Text Available The article assesses the main trends of the various conflict resolution processes in the Black Sea region. It emphasizes the transformation of the mediators’ role, including the increase of the EU efforts in the various peace processes. The author states that the absence of military actions, the narrowness of the existing peace formats and competition between the various mediating parties for leadership lead to the militarization of the region, the absence of the conflicts’ ‘ripeness’, new peace initiatives and an ‘all or nothing’ position on the part of the conflicting parties.
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Regional Employment Growth and Defense Spending.
1987-12-01
important part of regional growth. UI ACCA 9o1n For ’NDis i - Dljt s i-: . TABLE OF CONTENTS I. INTRODUCTION .. .. .. .... ..... .... .... .... ..... .. 7...Mideast and Great Lakes, all show spending to taxation ratios of less than one on a per capita basis, yet the Southwest and Rocky Mountain states have...because businesses look beyond the obvious nominal rate and locate according to effective rates of taxation , ie. actual tax liability. In addition, tax
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International Nuclear Information System (INIS)
Wang Wenguang; Tao Quan; Zhang Shouben
1997-10-01
Regional geologic characteristics, metallogenetic conditions and prospects of uranium ores in the central part of the Eastern Liaoning Province of North China is studied systematically. It demonstrates that the Archaean basement of the study area consists of a special type of granite-greenstone belts in China. It is called the granite-greenstone belts of the Liaoning-model, in which the granitic rocks are mainly migmatitic granite and granite-gneiss of migmatitic genesis. The greenstone belts in this area have undergone strong metamorphism. Large amounts of Precambrian geochronological studies have been made with U-Pb isotopic method on zircon; and a new Precambrian geologic time scale has been established. It is also proved that multistage activation of the Early Precambrian basement and the proto-platform took place in Early Proterozoic. Emphases are laid on uranium and thorium abundances and their variations as well as primary uranium contents of rocks in the granite-greenstone terrain and those of the Lower Proterozoic. At the same time, uraninite as accessory mineral in granitic rocks is found to exist more or less. Early Precambrian strata and many kinds of mineral deposits occurring in the strata are in origin chiefly of syngenetic hot brine sedimentation and of submarine extrusive gas-hydrothermal sedimentation superimposed by metamorphism. Metallogenetic features and models of various types of uranium deposits are studied emphatically and compared with similar large deposits abroad. In addition, overall synthetical appraisals are made for this area; and on this basis, prospecting directions and favourable sections of uranium metallization are suggested. (4 refs., 4 tabs.)
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Could aerosol emissions be used for regional heat wave mitigation?
Directory of Open Access Journals (Sweden)
D. N. Bernstein
2013-07-01
Full Text Available Geoengineering applications by injection of sulfate aerosols into the stratosphere are under consideration as a measure of last resort to counter global warming. Here a potential regional-scale application to offset the impacts of heat waves is critically examined. Using the Weather Research and Forecasting model with fully coupled chemistry (WRF-Chem, the effect of regional-scale sulfate aerosol emission over California in each of two days of the July 2006 heat wave is used to quantify potential reductions in surface temperature as a function of emission rates in a layer at 12 km altitude. Local meteorological factors yield geographical differences in surface air temperature sensitivity. For emission rates of approximately 30 μg m−2 s−1 of sulfate aerosols (with standard WRF-Chem size distribution over the region, temperature decreases of around 7 °C result during the middle part of the day over the Central Valley, one of the areas hardest hit by the heat wave. Regions more ventilated with oceanic air such as Los Angeles have slightly smaller reductions. The length of the hottest part of the day is also reduced. Advection effects on the aerosol cloud must be more carefully forecast for smaller injection regions. Verification of the impacts could be done via measurements of differences in reflected and surface downward shortwave. Such regional geoengineering applications with specific near-term target effects but smaller cost and side effects could potentially provide a means of testing larger scale applications. However, design considerations for regional applications, such as a preference for injection at a level of relatively low wind speed, differ from those for global applications. The size of the required injections and the necessity of injection close to the target region raise substantial concerns. The evaluation of this regional-scale application is thus consistent with global model evaluations, emphasizing that mitigation via
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Scattering properties of electromagnetic waves from metal object in the lower terahertz region
Chen, Gang; Dang, H. X.; Hu, T. Y.; Su, Xiang; Lv, R. C.; Li, Hao; Tan, X. M.; Cui, T. J.
2018-01-01
An efficient hybrid algorithm is proposed to analyze the electromagnetic scattering properties of metal objects in the lower terahertz (THz) frequency. The metal object can be viewed as perfectly electrical conducting object with a slightly rough surface in the lower THz region. Hence the THz scattered field from metal object can be divided into coherent and incoherent parts. The physical optics and truncated-wedge incremental-length diffraction coefficients methods are combined to compute the coherent part; while the small perturbation method is used for the incoherent part. With the MonteCarlo method, the radar cross section of the rough metal surface is computed by the multilevel fast multipole algorithm and the proposed hybrid algorithm, respectively. The numerical results show that the proposed algorithm has good accuracy to simulate the scattering properties rapidly in the lower THz region.
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The functional neuroanatomy of maternal love: mother's response to infant's attachment behaviors.
Noriuchi, Madoka; Kikuchi, Yoshiaki; Senoo, Atsushi
2008-02-15
Maternal love, which may be the core of maternal behavior, is essential for the mother-infant attachment relationship and is important for the infant's development and mental health. However, little has been known about these neural mechanisms in human mothers. We examined patterns of maternal brain activation in response to infant cues using video clips. We performed functional magnetic resonance imaging (fMRI) measurements while 13 mothers viewed video clips, with no sound, of their own infant and other infants of approximately 16 months of age who demonstrated two different attachment behaviors (smiling at the infant's mother and crying for her). We found that a limited number of the mother's brain areas were specifically involved in recognition of the mother's own infant, namely orbitofrontal cortex (OFC), periaqueductal gray, anterior insula, and dorsal and ventrolateral parts of putamen. Additionally, we found the strong and specific mother's brain response for the mother's own infant's distress. The differential neural activation pattern was found in the dorsal region of OFC, caudate nucleus, right inferior frontal gyrus, dorsomedial prefrontal cortex (PFC), anterior cingulate, posterior cingulate, thalamus, substantia nigra, posterior superior temporal sulcus, and PFC. Our results showed the highly elaborate neural mechanism mediating maternal love and diverse and complex maternal behaviors for vigilant protectiveness.
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Kati-Jasmin Kosonen
2003-01-01
In the era of knowledge society many regions and local communities/ towns are trying to compete with larger, growing cities over the knowledge and intellectual capital resources. Regional or local knowledge environment has become more important. Building innovation capacity and the institutional capacity as one part of it could be a development tool to some lagging behind-regions, (which are called as less-favoured regions) and quite often do not have universities of their own or successful i...
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Morphometric Analysis of Bone Resection in Anterior Petrosectomies.
Ahmed, Osama; Walther, Jonathan; Theriot, Krystle; Manuel, Morganne; Guthikonda, Bharat
2016-06-01
Introduction The anterior petrosectomy is a well-defined skull base approach to lesions such as petroclival meningiomas, posterior circulation aneurysms, petrous apex lesions (chondrosarcomas, cholesteatomas), ventrolateral brainstem lesions, clival chordomas, trigeminal neurinomas, and access to cranial nerves III, IV, V, and VII. Methods and Materials Fourteen anterior petrosectomies on eight cadaveric heads were performed in a skull base dissection laboratory. Predissection and postdissection thin-cut computed tomography scans were obtained to compare the bone resection. A computer program was used (InVivo5, Anatomage, San Jose, California, United States) to measure the bone resection and the improved viewing angle. Results The average bone removed in each plane was as follows: anterior to posterior plane was 10.57 mm ± 2.00 mm, superior to inferior was 9.39 mm ± 1.67 mm, and lateral to medial was 17.46 mm ± 4.64 mm. The average increased angle of view was 13.01 ± 2.35 degrees (Table 1). The average volume was 1786.94 ± 827.40 mm(3). Conclusions Anterior petrosectomy is a useful approach to access the ventrolateral brainstem region. We present a cadaveric study quantitating the volume of bone resection and improvement in the viewing angle. These data provide useful preoperative information on the utility of this skull base approach and the gain in the viewing angle after bony removal.
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Gestures, vocalizations, and memory in language origins.
Aboitiz, Francisco
2012-01-01
THIS ARTICLE DISCUSSES THE POSSIBLE HOMOLOGIES BETWEEN THE HUMAN LANGUAGE NETWORKS AND COMPARABLE AUDITORY PROJECTION SYSTEMS IN THE MACAQUE BRAIN, IN AN ATTEMPT TO RECONCILE TWO EXISTING VIEWS ON LANGUAGE EVOLUTION: one that emphasizes hand control and gestures, and the other that emphasizes auditory-vocal mechanisms. The capacity for language is based on relatively well defined neural substrates whose rudiments have been traced in the non-human primate brain. At its core, this circuit constitutes an auditory-vocal sensorimotor circuit with two main components, a "ventral pathway" connecting anterior auditory regions with anterior ventrolateral prefrontal areas, and a "dorsal pathway" connecting auditory areas with parietal areas and with posterior ventrolateral prefrontal areas via the arcuate fasciculus and the superior longitudinal fasciculus. In humans, the dorsal circuit is especially important for phonological processing and phonological working memory, capacities that are critical for language acquisition and for complex syntax processing. In the macaque, the homolog of the dorsal circuit overlaps with an inferior parietal-premotor network for hand and gesture selection that is under voluntary control, while vocalizations are largely fixed and involuntary. The recruitment of the dorsal component for vocalization behavior in the human lineage, together with a direct cortical control of the subcortical vocalizing system, are proposed to represent a fundamental innovation in human evolution, generating an inflection point that permitted the explosion of vocal language and human communication. In this context, vocal communication and gesturing have a common history in primate communication.
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Spielmann, A; Stutz, E
1983-10-25
The soybean chloroplast psb A gene (photosystem II thylakoid membrane protein of Mr 32 000, lysine-free) and the trn H gene (tRNAHisGUG), which both map in the large single copy region adjacent to one of the inverted repeat structures (IR1), have been sequenced including flanking regions. The psb A gene shows in its structural part 92% sequence homology with the corresponding genes of spinach and N. debneyi and contains also an open reading frame for 353 aminoacids. The aminoacid sequence of a potential primary translation product (calculated Mr, 38 904, no lysine) diverges from that of spinach and N. debneyi in only two positions in the C-terminal part. The trn H gene has the same polarity as the psb A gene and the coding region is located at the very end of the large single copy region. The deduced sequence of the soybean chloroplast tRNAHisGUG is identical with that of Zea mays chloroplasts. Both ends of the large single copy region were sequenced including a small segment of the adjacent IR1 and IR2.
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Directory of Open Access Journals (Sweden)
Sérgio D J Pena
2011-02-01
Full Text Available Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity of regional color categories correlated with ancestry. Using a panel of 40 validated ancestry-informative insertion-deletion DNA polymorphisms we estimated individually the European, African and Amerindian ancestry components of 934 self-categorized White, Brown or Black Brazilians from the four most populous regions of the Country. We unraveled great ancestral diversity between and within the different regions. Especially, color categories in the northern part of Brazil diverged significantly in their ancestry proportions from their counterparts in the southern part of the Country, indicating that diverse regional semantics were being used in the self-classification as White, Brown or Black. To circumvent these regional subjective differences in color perception, we estimated the general ancestry proportions of each of the four regions in a form independent of color considerations. For that, we multiplied the proportions of a given ancestry in a given color category by the official census information about the proportion of that color category in the specific region, to arrive at a "total ancestry" estimate. Once such a calculation was performed, there emerged a much higher level of uniformity than previously expected. In all regions studied, the European ancestry was predominant, with proportions ranging from 60.6% in the Northeast to 77.7% in the South. We propose that the immigration of six million Europeans to Brazil in the 19th and 20th centuries--a phenomenon described and intended as the "whitening of Brazil"--is in large part responsible for dissipating previous ancestry dissimilarities that reflected region-specific population histories. These findings, of both clinical and sociological importance for Brazil
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X-ray absorption intensity at high-energy region
International Nuclear Information System (INIS)
Fujikawa, Takashi; Kaneko, Katsumi
2012-01-01
We theoretically discuss X-ray absorption intensity in high-energy region far from the deepest core threshold to explain the morphology-dependent mass attenuation coefficient of some carbon systems, carbon nanotubes (CNTs), highly oriented pyrolytic graphite (HOPG) and fullerenes (C 60 ). The present theoretical approach is based on the many-body X-ray absorption theory including the intrinsic losses (shake-up losses). In the high-energy region the absorption coefficient has correction term dependent on the solid state effects given in terms of the polarization part of the screened Coulomb interaction W p . We also discuss the tail of the valence band X-ray absorption intensity. In the carbon systems C 2s contribution has some influence on the attenuation coefficient even in the high energy region at 20 keV.
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Transborder corporate integration in the Baltic Sea Region
Directory of Open Access Journals (Sweden)
Kuznetsov Alexei
2012-03-01
Full Text Available The paper examines flows of foreign direct investment within the Baltic region. The author demonstrates close investment ties among the EU members, which are of special importance for Estonia, Latvia and Lithuania. Transborder corporate integration in the region is characterized by significant imbalances. In many aspects, it can be viewed as Sweden’s economic expansion or development of domestic markets for northern European companies. Although many German, Polish and Russian companies are involved in corporate integration in the Baltic region, other vectors of their foreign economic relations are still more important for them. As a result, the integration of Russian business in the Baltic part of the European integration area is still rather weak despite Russia’s considerable foreign direct investment in the Baltic States.
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Regional transport model of atmospheric sulfates
International Nuclear Information System (INIS)
Rao, K.S.; Thomson, I.; Egan, B.A.
1977-01-01
As part of the Sulfate Regional Experiment (SURE) Design Project, a regional transport model of atmospheric sulfates has been developed. This quasi-Lagrangian three-dimensional grid numerical model uses a detailed SO 2 emission inventory of major anthropogenic sources in the Eastern U.S. region, and observed meteorological data during an episode as inputs. The model accounts for advective transport and turbulent diffusion of the pollutants. The chemical transformation of SO 2 and SO 4 /sup =/ and the deposition of the species at the earth's surface are assumed to be linear processes at specified constant rates. The numerical model can predict the daily average concentrations of SO 2 and SO 4 /sup =/ at all receptor locations in the grid region during the episode. Because of the spatial resolution of the grid, this model is particularly suited to investigate the effect of tall stacks in reducing the ambient concentration levels of sulfur pollutants. This paper presents the formulations and assumptions of the regional sulfate transport model. The model inputs and results are discussed. Isopleths of predicted SO 2 and SO 4 /sup =/ concentrations are compared with the observed ground level values. The bulk of the information in this paper is directed to air pollution meteorologists and environmental engineers interested in the atmospheric transport modeling studies of sulfur oxide pollutants
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[Selenium status of the inhabitants in the Kaluga region].
Golubkina, N A; Mal'tsev, G Iu; Bogdanov, N G; Vlaskina, S G; Alekseeva, I A; Khotimchenko, S A
1995-01-01
The human Se status of 8 areas of Kaluga region was studied. The mean serum Se levels 94 mg/l was significantly lower in the south compared to the northern area 126 mg/l. Areas with radioactive pollution possessed higher percentage of persons with low serum Se concentration than in regions without the pollution. Negative influence of radiation on serum Se level was confirmed also by epidemiological data for workers of Chernobil NNP (65 mg/l-workers attending to the reactor and 69 mg/l-for other employees). The same phenomenon was observed for males of Tula region who had taken part in the liquidation of an accident on the Chernobil NNP compared to other inhabitants of Tula region (78 mg/l and 89 mg/l correspondingly). The lowest antioxidant status (serum vitamin E, C and Se concentrations) in towns of Kaluga region with radioactive pollution possessed males of less than 60 years old.
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Regionalisation in Serbia: Between centralism and regionalism
Directory of Open Access Journals (Sweden)
Tripković Milan B.
2003-01-01
Full Text Available This paper is one of the results of the empirical research of the problem of regionalisation and multiculturality on the territory of Vojvodina. Only the part of gathered data, which concerns the regionalisation of Serbia and the status of Vojvodina, is used. Claiming that a regional state is not only a special form of the complex organization of state authorities, but also a special form of the whole social life, the author tries to define clear and reliable criteria of "good" or "desirable" regionalisation, which would avoid extreme centralism and extreme regionalism. Following the statistical territorial units, according to the standards of the European Union (NUTS the author recommends the a regional structure, understood as a special form of division of authorities: Serbia as a state or federal unit (NUTS 1 Vojvodina and Kosovo and Metohija as provinces (NUTS 2, regions (NUTS 3 sub-regions (NUTS 4 and municipalities (NUTS 5. In this context, it is suggested that the future Constitution of the Republic of Serbia should define only provinces and municipalities (NUTS 2 and NUTS 5, while for the forming of regions and sub-regions (NUTS 3 and NUTS 4 only the procedure and principles should be given - the rest would be left to spontaneous initiative of potential regional or sub-regional units. Two undesirable things would be avoided: A regionalisation imposed from "above", which could be understood as uncovered centralism, and a regionalism from "bellow" which tries to hide separatism under the mask of regionalisation and which leads not to better functioning and faster development of Serbia, but to disintegration.
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THE TOURISM IN THE OLTENIA REGION – STRATEGIES OF DEVELOPMENT
Directory of Open Access Journals (Sweden)
GHEORGHE GABRIEL SANDA
2017-12-01
Full Text Available Oltenia is one of the nine regions of Romania. Its tourism potential refers to an ensemble of components like geographical ones, historical, folkloric, religious and cultural, which create the premise for the development of diversified forms of tourism. Taking into consideration the fact that the region is not one of the most developed regions of Romania it is necessary to attract funds from the European Union to create an image of the destination so that more tourists will come in the area and these tourists will buy different tourism products. Tourism represents an important part in the economy of each country. There are regions in the entire world which have managed to create a unique image by creating a unitary tourism product. Regions like Toscana in Italy, Bordeaux in France, Campania from Italy, Palawan in Philippines. Following the examples of these regions we have in Romania regions like Maramures and Bucovina which attract annually tourists not only from Romania but also from other countries. We belive that the main strategy for Oltenia Region is the publicity so this Region be as well known as the other touristical Regions of Romania (Maramures, Bucovina.
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Formation and Eruption Process of a Filament in Active Region NOAA 12241
Energy Technology Data Exchange (ETDEWEB)
Wang, Jincheng; Yan, Xiaoli; Qu, ZhongQuan; Xue, Zhike; Yang, Liheng [Yunnan Observatories, Chinese Academy of Sciences, Kunming 650011 (China)
2017-04-20
In order to better understand active-region filaments, we present an intensive study on the formation and eruption of a filament in active region NOAA 12241 during the period from 2014 December 18 to 19. Using observations from the Helioseismic and Magnetic Imager (HMI) vector magnetograms, we investigate the helicity injection rate, Lorentz force, and vertical electric current in the entire region associated with the filament. The helicity injection rate before eruption is found to be larger than that after eruption, while the vertical electric current undergoes an increase at first and then a gradual decrease, similar to what the magnetic flux undergoes. Meanwhile, we find that the right part of the filament is formed by magnetic reconnection between two bundles of magnetic field lines while the left part originated from shearing motion. The interaction of the two parts causes the eruption of this filament. The mean horizontal magnetic fields in the vicinity of the magnetic polarity inversion line (PIL) enhance rapidly during the eruption. Another striking phenomenon, where the vertical electric currents close to the magnetic PIL suddenly expand toward two sides during the eruption, is found. We propose that this fascinating feature is associated with the release of energy during the eruption.
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IA-Regional-Radio - Social Network for Radio Recommendation
Dziczkowski, Grzegorz; Bougueroua, Lamine; Wegrzyn-Wolska, Katarzyna
This chapter describes the functions of a system proposed for the music hit recommendation from social network data base. This system carries out the automatic collection, evaluation and rating of music reviewers and the possibility for listeners to rate musical hits and recommendations deduced from auditor's profiles in the form of regional Internet radio. First, the system searches and retrieves probable music reviews from the Internet. Subsequently, the system carries out an evaluation and rating of those reviews. From this list of music hits, the system directly allows notation from our application. Finally, the system automatically creates the record list diffused each day depending on the region, the year season, the day hours and the age of listeners. Our system uses linguistics and statistic methods for classifying music opinions and data mining techniques for recommendation part needed for recorded list creation. The principal task is the creation of popular intelligent radio adaptive on auditor's age and region - IA-Regional-Radio.
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THOUGHTS ON THE REGIONALIZATION PROCESS IN COMPARATIVE LAW
Directory of Open Access Journals (Sweden)
CLAUDIA GILIA
2013-05-01
Full Text Available Regionalization is a complex and smooth process in terms of territorial organization of the states which chose this form of organization, but also from the perspective of how the regional systems understood to exercise their competences. The regionalization process did not only yield profit for the inhabitants of those administrative entities, but it also caused problems to national governors (e.g. demands for the federalization of the state in question, proposals to gain independence from the state they are part of, issues related to state security – terrorists attacks etc.. Our paper shall conduct an assessment over two states which chose this form of regionalization: The United Kingdom of Great Britain and North Ireland and Spain. Given the context of the upcoming constitutional and legislative changes envisaged by the Romanian government, we consider that our research can be regarded as a useful tool, designed to develop certain constitutional directives, which are intended to acquire the best solutions from European experiences.
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The Guayaquil region: Territorial development and social inclusion
Directory of Open Access Journals (Sweden)
Rafael Guerrero Burgos
2013-10-01
Full Text Available The article looks at the process of social and economic development in the Guayaquil river basin based on a model of agro exports commodity chains. The territory or region is analyzed by looking at social and economic dynamics as opposed to political administrative divisions, which covers a wider area that extends to the provinces of Los Ríos, Manabí and Santa Elena. This article is part of a more extensive research project on Guayaquil and the region, that looks at rural urban linkages and how the common feature of the regional economy is the dependence of the rural periphery on Guayaquil either for industrial or export processing. By focusing on the main agro-commodity chains that shape the territory, including coffee, cocoa and banana for export, as well as rice and corn for the internal market, one can see how regional development was built on the basis of the rural economy.
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Policy Paper 05: Regional Cooperation and Environmental Issues in Northeast Asia
Hayes, Peter; Zarsky, Lyuba
1993-01-01
Hayes and Zarsky describe the rapidly emerging agenda for regional collaboration on environmental issues in Northeast Asia. In Part One, they describe briefly some of the major transfrontier or regional environmental issues in Northeast Asia that represent a menu of opportunities for cooperation (and potential conflict) between states. These issues include transfrontier air pollution (acid rain only), marine pollution (radionuclides and oil only), migratory species (fish only), and trade-envi...
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North region wind power prospects and its impact on the environment
International Nuclear Information System (INIS)
Kniazeva, V.; Marchuk, S.
1992-01-01
The article presents the analysis of wind energy prospects for the Kola Peninsula based on wind energy potential and environment improvement in the region. Data on ecological situation in the region and harmful industrial and power engineering outbursts is also provided. It is suggested to use part of the money received as payments from different organizations for harmful influence on environment to finance ecologically clean wind energy project development
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THE TOURISM POTENTIAL OF NORTHERN PORTUGAL AND ITS RELEVANCE FOR A REGIONAL BRANDING STRATEGY
Oliveira, Eduardo
2014-01-01
The purpose of this article is to explore a potential regional branding strategy for the northern part of Portugal, emphasizing the regional tourism potential. Furthermore, it aims to clarify the answers of the following research questions: i) is tourism a strategic domain with the potential to
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Directory of Open Access Journals (Sweden)
Eduardo Terrero Matos
2015-06-01
Full Text Available En la Parte I de este artículo fue establecido el algoritmo general de un procedimiento para el diseño del muestreo de la velocidad del viento cuyos resultados tengan la capacidad de minimizar el error probable medio durante una estimación del comportamiento espacio-temporal de la velocidad del viento. En la Parte II se describe el algoritmo de selección de puntos de muestreo y el algoritmo para el cálculo del error probable de estimación. El procedimiento para diseñarlas redes de muestreo eólico es implementado en una aplicación informática que facilita la aplicación del procedimiento a la selección de los puntos donde se ubicarán las torres anemométricas en una región promisoria del municipio Moa en la Provincia Holguín, Cuba. Los resultados obtenidos son comparados con el diseño obtenido en el año 2007 por la Empresa de Ingeniería y Proyectos de Electricidad del Ministerio de Energía y Minas de la República de Cuba.In Part I of this article was established the general algorithmof a procedure for the sampling design of the wind speed and the results have the ability to minimize the average probable error for an estimate of the conduct spatiotemporal wind speed. In Part II the selection algorithm of sampling points and the algorithm for calculating the probable error estimation is described. The procedure for the samplingdesign is implemented in an computer software that facilitates the application from the procedure to the selection of the points where theanemometer towers will be located in a promissory region of the municipality Moa in the province Holguín, Cuba. The results are compared with the design obtained in 2007 by the Empresa de Ingeniería y Proyectos de Electricidad of the Ministry of Energy and Mines of the Republic of Cuba.
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Pollution sources and groundwater quality in the Coastal region of the Yugoslav part of the Danube
International Nuclear Information System (INIS)
Komatina, S.
1997-01-01
In order to access the vulnerability and risk of the aquifer system in the Yugoslav part of the Danube, as the primary source of drinking water for a numerically substantial community, industrial purposes and irrigation, as well as a high concentration of civil, industrial and agricultural activities (hence, a potential source of pollution of the groundwater resources through land occupation and use as well as the disposal of solid and liquid wastes), a great hydro-geophysical exploration was performed. Within the lower part of the plain, exploratory test of Salinac field, near Smederevo town, was particularly investigated. The reason why is because that part is also an area of the mouth of the Velika Morava into the Danube, where Derdap reservoir is located. Task of complex exploration was to delineate the aquifer, obtain appropriate parameters (groundwater level, groundwater chemistry, clay content, filtration characteristics and physical parameters of geological functions), as well as to map the aquifer vulnerability, in order to prevent and moderate a harmful influence of the performed reservoir on the environment (increased groundwater infiltration from the reservoir into surrounding rocks, permanent groundwater level raising, etc.). Based on the results, zoning of the study area according to the aquifer vulnerability has been done. Then, land-use planning and development of strategy for groundwater protection and management was possible. In the paper, not only sources of contamination, characteristics of pollutants and their influence on the groundwater quality was presented, but also content of organic matters, phosphates and nitrogen compounds, etc. Further, means of protection and management are discussed, as well as the appropriate legal regulations. (author)
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Functional MRI study of diencephalic amnesia in Wernicke-Korsakoff syndrome.
Caulo, M; Van Hecke, J; Toma, L; Ferretti, A; Tartaro, A; Colosimo, C; Romani, G L; Uncini, A
2005-07-01
Anterograde amnesia in Wernicke-Korsakoff syndrome is associated with diencephalic lesions, mainly in the anterior thalamic nuclei. Whether diencephalic and temporal lobe amnesias are distinct entities is still not clear. We investigated episodic memory for faces using functional MRI (fMRI) in eight controls and in a 34-year-old man with Wernicke-Korsakoff syndrome and diencephalic lesions but without medial temporal lobe (MTL) involvement at MRI. fMRI was performed with a 1.5 tesla unit. Three dual-choice tasks were employed: (i) face encoding (18 faces were randomly presented three times and subjects were asked to memorize the faces); (ii) face perception (subjects indicated which of two faces matched a third face); and (iii) face recognition (subjects indicated which of two faces belonged to the group they had been asked to memorize during encoding). All activation was greater in the right hemisphere. In controls both the encoding and recognition tasks activated two hippocampal regions (anterior and posterior). The anterior hippocampal region was more activated during recognition. Activation in the prefrontal cortex was greater during recognition. In the subject with Wernicke-Korsakoff syndrome, fMRI did not show hippocampal activation during either encoding or recognition. During recognition, although behavioural data showed defective retrieval, the prefrontal regions were activated as in controls, except for the ventrolateral prefrontal cortex. fMRI activation of the visual cortices and the behavioural score on the perception task indicated that the subject with Wernicke-Korsakoff syndrome perceived the faces, paid attention to the task and demonstrated accurate judgement. In the subject with Wernicke-Korsakoff syndrome, although the anatomical damage does not involve the MTL, the hippocampal memory encoding has been lost, possibly as a consequence of the hippocampal-anterior thalamic axis involvement. Anterograde amnesia could therefore be the expression of
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Innovative regions and industrial clusters in hydrogen and fuel cell technology
DEFF Research Database (Denmark)
Madsen, Anne Nygaard; Andersen, Per Dannemand
2010-01-01
Regional governments in Europe seem to be playing an increasing role in hydrogen and fuel cell (H2FC) development. A number of regions are supporting demonstration projects and building networks among regional stakeholders to strengthen their engagement in H2FC technology. In this article, we...... will analyse regions that are highly engaged in H2FC activity, based on three indicators: existing hydrogen infrastructure and production sites, general innovativeness and the presence of industrial clusters with relevance for H2FC. Our finding is that regions with high activity in H2FC development are also...... innovative regions in general. Moreover, the article highlights some industrial clusters that create favourable conditions for regions to take part in H2FC development. Existing hydrogen infrastructure, however, seems to play only a minor role in a region’s engagement. The article concludes that, while...
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The regional costs and benefits of acid rain control
International Nuclear Information System (INIS)
Berkman, M.P.
1991-01-01
Congress recently enacted acid rain control legislation as part of the 1990 Clean Air Act Amendments following a decade-long debate among disparate regional interests. Although Congress succeeded in drafting a law acceptable to all regions, the regional costs and benefits of the legislation remain uncertain. The research presented here attempts to estimate the regional costs and benefits and the economic impacts of acid rain controls. These estimates are made using a modeling system composed of econometric, linear programming and input-output models. The econometric and linear programming components describe markets for electricity and coal. The outputs of these components including capital investment, electricity demand, and coal production are taken as exogenous inputs by a multiregional input-output model. The input-output model produces estimates of changes in final demand, gross output, and employment. The utility linear programming model also predicts sulfur dioxide emissions (an acid-rain precursor). According to model simulations, the costs of acid rain control exceed the benefits for many regions including several regions customarily thought to be the major beneficiaries of acid rain control such as New England
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DGCR6 at the proximal part of the DiGeorge critical region is involved in conotruncal heart defects
Gao, Wenming; Higaki, Takashi; Eguchi-Ishimae, Minenori; Iwabuki, Hidehiko; Wu, Zhouying; Yamamoto, Eiichi; Takata, Hidemi; Ohta, Masaaki; Imoto, Issei; Ishii, Eiichi; Eguchi, Mariko
2015-01-01
Cardiac anomaly is one of the hallmarks of DiGeorge syndrome (DGS), observed in approximately 80% of patients. It often shows a characteristic morphology, termed as conotruncal heart defects. In many cases showing only the conotruncal heart defect, deletion of 22q11.2 region cannot be detected by fluorescence in situ hybridization (FISH), which is used to detect deletion in DGS. We investigated the presence of genomic aberrations in six patients with congenital conotruncal heart defects, who show no deletion at 22q11.2 in an initial screening by FISH. In these patients, no abnormalities were identified in the coding region of the TBX1 gene, one of the key genes responsible for the phenotype of DGS. However, when copy number alteration was analyzed by high-resolution array analysis, a small deletion or duplication in the proximal end of DiGeorge critical region was detected in two patients. The affected region contains the DGCR6 and PRODH genes. DGCR6 has been reported to affect the expression of the TBX1 gene. Our results suggest that altered dosage of gene(s) other than TBX1, possibly DGCR6, may also be responsible for the development of conotruncal heart defects observed in patients with DGS and, in particular, in those with stand-alone conotruncal heart defects. PMID:27081520
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Fernandez, J. P. R.; Franchito, S. H.; Rao, V. B.
2006-09-01
This study investigates the capabilities of two regional models (the ICTP RegCM3 and the climate version of the CPTEC Eta model - EtaClim) in simulating the mean climatological features of the summer quasi-stationary circulations over South America. Comparing the results with the NCEP/DOE reanalysis II data it is seen that the RegCM3 simulates a weaker and southward shifted Bolivian high (BH). But, the Nordeste low (NL) is located close to its climatological position. In the EtaClim the position of the BH is reproduced well, but the NL is shifted towards the interior of the continent. To the east of Andes, the RegCM3 simulates a weaker low level jet and a weaker basic flow from the tropical Atlantic to Amazonia while they are stronger in the EtaClim. In general, the RegCM3 and EtaClim show, respectively a negative and positive bias in the surface temperature in almost all regions of South America. For both models, the correlation coefficients between the simulated precipitation and the GPCP data are high over most of South America. Although the RegCM3 and EtaClim overestimate the precipitation in the Andes region they show a negative bias in general over the entire South America. The simulations of upper and lower level circulations and precipitation fields in EtaClim were better than that of the RegCM3. In central Amazonia both models were unable to simulate the precipitation correctly. The results showed that although the RegCM3 and EtaClim are capable of simulating the main climatological features of the summer climate over South America, there are areas which need improvement. This indicates that the models must be more adequately tuned in order to give reliable predictions in the different regions of South America.
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International Nuclear Information System (INIS)
Dauphin, Francois; Fontaine, Frederick
2013-02-01
The first part of this document aims at presenting perspectives of emergence of new energy production, consumption and storage sources, and their impacts on energy (electricity, gas, heat) distribution and transport networks. It is based on two scenarios: the regional climate-air-energy scheme, and the regional Negawatt scenario. The objective was to select a limited number of aspects: solutions enabling an optimal injection of biogas produced in the concerned region, development of photovoltaic energy and electric vehicles and their impact on the balance of medium-voltage and low-voltage networks, and smart grid technologies and their possible impact on the optimisation of electric network management. The second part reports the detailed study of these issues. It more particularly addresses technical impacts of different sectors on electric and gas networks in Provence-Alpes-Cote d'Azur, technical, economic and organisational assets of smart grid technologies, investments policies and implementation planning, and resulting evolutions for energy markets. Related documents published by ERDF and GrDF are provided
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Directory of Open Access Journals (Sweden)
Paul Sutton
2012-10-01
Full Text Available Abstract:This paper examines one important dimension of the European Union's (EU 'regional' engagement with the Caribbean: its relations with the Overseas Countries and Territories (OCT, with a particular focus on the possibility of furthering the policy goals of greater regional integration and cooperation. It does so in three parts. The first sets out the basis for current EU policy to the OCT which has been under discussion between the EU, the OCT and the four EU member states most involved (Denmark, France, the Netherlands and the United Kingdom since 2008. It reports EU proposals for change and the responses to them by the Caribbean OCTs. The second part examines EU policy toward promoting greater regional cooperation among the Caribbean OCTs and between them and some of the other Caribbean regional organizations. Three distinct frameworks for cooperation and integration are discussed: with independent states as established in the Caribbean Community, the Caribbean Forum and the Economic Partnership Agreement; with the French departments and collectivities; and with the Caribbean OCT. In each the position of the Caribbean OCT is situated. The final part briefly discusses the creation of a 'new' framework for regional cooperation specific for the Caribbean OCT which will most closely match their interests in the Caribbean.Resumen: La Unión Europea y la Región del Caribe: Situando a los Países y Territorios de Ultramar del CaribeEste ensayo analiza una dimensión importante de la Unión Europea (UE 'regional' y su compromiso con el Caribe: de igual manera sus relaciones con los Países y Territorios de Ultramar (PTU, con un enfoque particular sobre la posibilidad de promover los objetivos de la política con una mayor integración regional y cooperación. Este proceso se desglosa en tres partes. La primera establece la base para la actual política de la UE hacia los PTU, ya que esta ha sido objeto de debate entre los mismos y los cuatro
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Beyond the eye of the beholder: on a forensic descriptor of the eye region
Zeinstra, Christopher Gerard; Veldhuis, Raymond N.J.; Spreeuwers, Lieuwe Jan
The task of forensic facial experts is to assess the likelihood whether a suspect is depicted on crime scene images. They typically (a) use morphological analysis when comparing parts of the facial region, and (b) combine this partial evidence into a final judgment. Facial parts can be considered as
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Directory of Open Access Journals (Sweden)
Nora Sainz Gsell
2005-10-01
Full Text Available This work deals with Central Asia, beginning with an analysis of the characteristics of international insertion of the area as a whole and of the former Soviet republics that comprise it. In a general way, it aims to analyse the evolution of Central Asia from a peripheral region to an area that generates behaviours and receives the application of policies on the part ofinternational actors. In the first part of the study, it mentions a series of particularities of the republics that have determined the relationships in the region(the Central Asian order and those between the region and the outside world; it indicates geo-historical and economic-strategic aspects. In the second part, it examines the foreign policy of the republics in the post-Cold War era from the singularities of domestic policy. And, in the third part, it analyses, according to the aforementioned peculiarities, the policies that the area and each State has generated in international actors, both regional ones and global ones, and which have transformed the region from a peripheral one to a geopolitically emerging one.
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Final report : Occupational gap analysis, volume 2 Wood Buffalo region
International Nuclear Information System (INIS)
2002-06-01
The general economy of the Wood Buffalo region of Alberta has improved in recent years due to the expansion of the oil sand industry. Many of the oil sands projects are situated in the southern part of the region and are serviced out of Lac LaBiche. This paper examines the implications of this economic growth for the regional supply and demand of workers in key occupational categories. In particular, it projects employment opportunities that are directly attributed to the regional economic expansion, and assesses whether there will be an adequate supply of workers to meet the demand for new and replacement employees. The report includes: an overview of the regional economy; a population forecast for the region and the demand for workers in selected occupations; an analysis of whether or not the new labour force entrants will choose the selected occupations; and, a supply and demand analysis. 7 tabs., 2 figs., 5 appendices
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Calculation of Void Volume Fraction in the Subcooled and Quality Boiling Regions
International Nuclear Information System (INIS)
Rouhani, S.Z.; Axelsson, E.
1968-10-01
The complex problem of void calculation in the different regions of flow boiling is divided in two parts. The first part includes only the description of the mechanisms and the calculation of the rates of heat transfer for vapour and liquid. It is assumed that heat is removed by vapour generation, heating of the liquid that replaces the detached bubbles, and in some parts, by single phase heat transfer. By considering the rate of vapour condensation in liquid, an equation for the differential changes in the true steam quality throughout the boiling regions is obtained. Integration of this equation yields the vapour weight fraction at any position. The second part of the problem concerns the determination of the void fractions corresponding to the calculated steam qualities. For this purpose we use the derivations of Zuber and Findlay. This model is compared with data from different geometries including small rectangular channels and large rod bundles. The data covered pressures from 19 to 138 bars, heat fluxes from 18 to 120 W/cm 2 with many different subcoolings and mass velocities. The agreement is generally very good
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Calculation of Void Volume Fraction in the Subcooled and Quality Boiling Regions
Energy Technology Data Exchange (ETDEWEB)
Rouhani, S Z; Axelsson, E
1968-10-15
The complex problem of void calculation in the different regions of flow boiling is divided in two parts. The first part includes only the description of the mechanisms and the calculation of the rates of heat transfer for vapour and liquid. It is assumed that heat is removed by vapour generation, heating of the liquid that replaces the detached bubbles, and in some parts, by single phase heat transfer. By considering the rate of vapour condensation in liquid, an equation for the differential changes in the true steam quality throughout the boiling regions is obtained. Integration of this equation yields the vapour weight fraction at any position. The second part of the problem concerns the determination of the void fractions corresponding to the calculated steam qualities. For this purpose we use the derivations of Zuber and Findlay. This model is compared with data from different geometries including small rectangular channels and large rod bundles. The data covered pressures from 19 to 138 bars, heat fluxes from 18 to 120 W/cm{sup 2} with many different subcoolings and mass velocities. The agreement is generally very good.
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The rheological structure of the lithosphere in the Eastern Marmara region, Turkey
Oruç, Bülent; Sönmez, Tuba
2017-05-01
The aim of this work is to propose the geometries of the crustal-lithospheric mantle boundary (Moho) and lithosphere-asthenosphere boundary (LAB) and the 1D thermal structure of the lithosphere, in order to establish a rheological model of the Eastern Marmara region. The average depths of Moho and LAB are respectively 35 km and 51 km from radially averaged amplitude spectra of EGM08 Bouguer anomalies. The geometries of Moho and LAB interfaces are estimated from the Parker-Oldenburg gravity inversion algorithm. Our results show the Moho depth varies from 31 km at the northern part of North Anatolian Fault Zone (NAFZ) to 39 km below the mountain belt in the southern part of the NAFZ. The depth to the LAB beneath the same parts of the region ranges from 45 km to 55 km. Having lithospheric strength and thermal boundary layer structure, we analyzed the conditions of development of lithosphere thinning. A two-dimensional strength profile has been estimated for rheology model of the study area. Thus we suggest that the rheological structure consists of a strong upper crust, a weak lower crust, and a partly molten upper lithospheric mantle.
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Towards a regional beef carcass classification system for Southern ...
African Journals Online (AJOL)
This is partly because the current beef carcass grading and classification systems used in the region value inappropriately carcasses from slow-maturing indigenous cattle breeds that are ideally suited to being marketed off natural pasture. The existing systems use carcass yield and quality attributes, but do not predict ...
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Effects of forest fires in southern and central of Zabaykal region
Directory of Open Access Journals (Sweden)
L. V. Buryak
2016-12-01
Full Text Available The fire frequency situation in Zabaykal region from 1964 to 2015 is evaluated and discussed in the paper. The main reasons of decadal increase of fire numbers and the area burned are revealed. The main reasons of high fire frequency and the increase of fire activity in the last decades are shown. The characteristics of the weather conditions in the years of high fire frequency are presented. Fire activity was found to increase not only because of the droughts in the last decades but also due to forest disturbances in Zabaykalsky Krai by illegal logging. Based on the data from 170 sample sites laid out with the use of satellite images, forest inventory data and results of ground sample transects, the impact of the wildfires of different type, form and severity on tree mortality in the light-coniferous forests was estimated, as well as the amount of tree regeneration in the forest areas disturbed by fires, logged sites (both burned and unburned, and sites burned repeatedly was evaluated. Wildfires in the Zabaykal region were found to be strong ecological factor influencing on the probability of existence of many forest ecosystems. In case of further climate warming and repeated fires, the part of the forests may transform to the non forest areas. The steppification of the burned sites in the southern forest-steppe regions and in the low parts of the southern slopes at the border with steppe landscapes as well as desertification in the central parts of the region and swamping of burned sites located in the wet soils are observed. Wind and water soil erosion happens at the large burned sites.
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Localization of the brainstem GABAergic neurons controlling paradoxical (REM sleep.
Directory of Open Access Journals (Sweden)
Emilie Sapin
Full Text Available Paradoxical sleep (PS is a state characterized by cortical activation, rapid eye movements and muscle atonia. Fifty years after its discovery, the neuronal network responsible for the genesis of PS has been only partially identified. We recently proposed that GABAergic neurons would have a pivotal role in that network. To localize these GABAergic neurons, we combined immunohistochemical detection of Fos with non-radioactive in situ hybridization of GAD67 mRNA (GABA synthesis enzyme in control rats, rats deprived of PS for 72 h and rats allowed to recover after such deprivation. Here we show that GABAergic neurons gating PS (PS-off neurons are principally located in the ventrolateral periaqueductal gray (vlPAG and the dorsal part of the deep mesencephalic reticular nucleus immediately ventral to it (dDpMe. Furthermore, iontophoretic application of muscimol for 20 min in this area in head-restrained rats induced a strong and significant increase in PS quantities compared to saline. In addition, we found a large number of GABAergic PS-on neurons in the vlPAG/dDPMe region and the medullary reticular nuclei known to generate muscle atonia during PS. Finally, we showed that PS-on neurons triggering PS localized in the SLD are not GABAergic. Altogether, our results indicate that multiple populations of PS-on GABAergic neurons are distributed in the brainstem while only one population of PS-off GABAergic neurons localized in the vlPAG/dDpMe region exist. From these results, we propose a revised model for PS control in which GABAergic PS-on and PS-off neurons localized in the vlPAG/dDPMe region play leading roles.
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Africa region population projections - 1988-89
Vu, My T.; Bos, Eduard; Bulatao, Rodolfo A.
1988-01-01
The report which is part of a series, presents population projection tables for each country in the Africa region. The report provides an explanation on projection results as well as a description of the projection methodology, summarizing the main results. The projections in the report cover the period 1985 - 2150. This time period allows countries to approach stability. The key elements in these projections are the base year (mid 1985). Total population estimates and age - sex structures ar...
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EPA Region 1 Environmentally Sensitive Areas
This coverage represents polygon equivalents of environmentally sensitive areas (ESA) in EPA Region I. ESAs were developed as part of an EPA headquarters initiative based on reviews of various regulatory and guidance documents, as well as phone interviews with federal/state/local government agencies and private organizations. ESAs include, but are not limited to, wetlands, biological resources, habitats, national parks, archaeological/historic sites, natural heritage areas, tribal lands, drinking water intakes, marinas/boat ramps, wildlife areas, etc.
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MR images of radiofrequency lesions following ventrolateral thalamotomy
Energy Technology Data Exchange (ETDEWEB)
Shinno, Kiyohito [Tokushima Univ. (Japan). School of Medicine
1992-10-01
In 14 patients with Parkinson's disease and one with intension tremor, thalamotomy lesions were examined with magnetic resonance (MR) imaging at acute (day 3), subacute (day 14), and chronic (2 months to 1 year) stages after surgery. Standard radiofrequency lesion-making was repeated up to a complete abolition of motor symptoms. At acute stage, three or four distinct zones of the thalamus were seen on MR images: the central and third zones were of low signal on T1- and high signal on T2-weighted images; and the second zone was isointense on T1- and of low signal on T2-weighted images. The out-most zone was of high signal on T2-weighted images, but not noticeable on T1-weighted images. MR appearances at subacute stage showed hyperintensity on T1- and T2-weighted images for both the central and third zones. The second zone became smaller and fainter, although there was no signal change. The out-most zone became much smaller on T2-weighted images and was invisible on T1-weighted images. At subacute stage, T2-weighted images showed two distinct layers: the inner layer was of high signal and the outer layer was of low signal. T1-weighted imaging showed mixed isointensity and hyperintensity. At chronic stage one year after surgery, the lesions became small, round cystic with low signal on T1- and either low or high signal on T2-weighted images. At acute stage, the central, second, and third zones seemed reflect a small area of needle destruction composed of blood and edema, a layer of coagulation necrosis, and a layer of hemorrhagic colliquation necrosis with edema, respectively. Water content increased due to edema at acute stage; and hemoglobin changed paramagentic forms in association with diminution of edema in subacute or chronic stage.(N.K.).
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New Regionalisms and Radical Identity Formation in Latin America: Towards an “Alter-global” Paradigm
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Efe Can Gürcan
2010-12-01
Full Text Available The post-Cold War period has witnessed the simultaneous emergence of a new trend of regionalism and a radicalized form of identity politics in Latin America, in parallel with the rise of numerous new left governments and alter-globalist social movements confronting neo-liberalism. In fact, the globalization of this continental struggle through a new trend of regionalism is a process which illustrates the fact that in today’s world, national, regional and global identities are complexly entwined beyond “wellestablished” dichotomies such as nationalism-cosmopolitanism. This paper suggests that regionalism could be an efficient tool to promote the formation of new collective identities at the global level by linking social struggles at the national level to the global resistance movement against neo-liberalism, as observed in the current Latin American experience of new regionalism. The first part of the paper would attempt to explain the actual significance of regionalism and the challenge of “identity formations” under globalization, and would develop an alternative theoretical approach based on Mittelman’s underrated concept of “transformative regionalism” (2004, besides elaborating the basic premises of the New Regionalism School. In turn, the second part would discuss the transformative potential of the new Latin American regionalisms through the involvement of social movements, mostly based on the experience of ALBA, but not without mentioning also the experience of TELESUR, UNASUR and Bank of the South. Finally, the concluding parts would deal with alternative policy recommendations and the emerging research agenda of new regionalism in Latin America, with a special focus on the case of the rising food sovereignty (globalization of peasant identities and counter-hegemonic mass education movements (the “HEFA regime” within the context of “radical identity formation”. Thereby, the paper attempts to explain how local
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Directory of Open Access Journals (Sweden)
Valentina F. Lapo
2017-01-01
Full Text Available The most part of stimulation methods in Russia are concentrated in legal documents of the regions of the Russian Federation. They directed on intensification of investment activity in regions. How similar are these investment stimulation conceptions? There is no mention in the literature of the methodical questions of quantitative analysis and inter-regional comparisons. In addition, there are no results of statistical research of inter-regional correlations of stimulation methods and analysis of dynamics of this process. There are no special measuring instruments. The presented work is aimed at completion of these blanks. The approach for the spatial correlation analysis of legislative norms is offered in research. Classification of investments’ stimulation methods is developed. The way of preparing and coding data for research is offered. The approach and system of coefficients for the analysis of inter-regional interrelations of legislative systems of investments’ stimulation is offered. A proximity coefficient of regional legislation, a factor of structure similarity and a dynamic coincidence index are proposed. The space-time base of investment stimulation methods on Russian Federation regions for 12 years is collected and statistically processed for research. There are only 758 documents. A source of texts is a site of the Ministry of Justice of the Russian Federation.Research of documents has allowed revealing a number of laws in formation of regional investment stimulation systems. The regions that are the most similar in terms of structure of stimulation methods are identified. We have found the group of regions for which it is observed the increase in similarity of the legislation and the group with the reduction of similarity. Therefore, it is obvious that the general trend to reduction of similarity in the legislation takes place between Krasnoyarsk territory and the other regions of the Russian Federation. Calculations have
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Welborn, B Locke; Gunter, Benjamin C; Vezich, I Stephanie; Lieberman, Matthew D
2017-04-01
The false consensus effect (FCE), the tendency to project our attitudes and opinions on to others, is a pervasive bias in social reasoning with a range of ramifications for individuals and society. Research in social psychology has suggested that numerous factors (anchoring and adjustment, accessibility, motivated projection, etc.) may contribute to the FCE. In this study, we examine the neural correlates of the FCE and provide evidence that motivated projection plays a significant role. Activity in reward regions (ventromedial pFC and bilateral nucleus accumbens) during consensus estimation was positively associated with bias, whereas activity in right ventrolateral pFC (implicated in emotion regulation) was inversely associated with bias. Activity in reward and regulatory regions accounted for half of the total variation in consensus bias across participants (R 2 = .503). This research complements models of the FCE in social psychology, providing a glimpse into the neural mechanisms underlying this important phenomenon.
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Verma, Vivek; Iftekaruddin, Zaid; Badar, Nida; Hartsell, William; Han-Chih Chang, John; Gondi, Vinai; Pankuch, Mark; Gao, Ming; Schmidt, Stacey; Kaplan, Darren; McGee, Lisa
2017-05-01
This study evaluates acute toxicity outcomes in breast cancer patients treated with adjuvant proton beam therapy (PBT). From 2011 to 2016, 91 patients (93 cancers) were treated with adjuvant PBT targeting the intact breast/chest wall and comprehensive regional nodes including the axilla, supraclavicular fossa, and internal mammary lymph nodes. Toxicity was recorded weekly during treatment, one month following treatment, and then every 6months according to the Common Terminology Criteria for Adverse Events (CTCAE) v4.0. Charts were retrospectively reviewed to verify toxicities, patient parameters, disease and treatment characteristics, and disease-related outcomes. Median follow-up was 15.5months. Median PBT dose was 50.4 Gray relative biological effectiveness (GyRBE), with subsequent boost as clinically indicated (N=61, median 10 GyRBE). Chemotherapy, when administered, was given adjuvantly (N=42) or neoadjuvantly (N=46). Grades 1, 2, and 3 dermatitis occurred in 23%, 72%, and 5%, respectively. Eight percent required treatment breaks owing to dermatitis. Median time to resolution of dermatitis was 32days. Grades 1, 2, and 3 esophagitis developed in 31%, 33%, and 0%, respectively. PBT displays acceptable toxicity in the setting of comprehensive regional nodal irradiation. Copyright © 2017. Published by Elsevier B.V.
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International Nuclear Information System (INIS)
Stefaniak, B.
2002-01-01
As described earlier, a dedicated computer program was developed for quantitative evaluation of regional lung perfusion defects, visualized by pulmonary scintigraphy. The correctness of the basic assumptions accepted to construct the algorithms and of the all program functions needed to be checked, before application of the program into the clinical routine. The aim of this study was to verified the program using various software instruments and physical models. Evaluation of the proposed method was performed using software procedures, physical lung phantom, and selected lung image.The reproducibility of lung regions, defined by the program was found excellent. No significant distortion of registered data was observed after ROI transformation into the circle and retransformation into the original shape. The obtained results comprised parametric presentation of activity defects as well as a set of numerical indices which defined extent and intensity of decreased counts density. Among these indices PD2 and DM* were proved the most suitable for the above purposes. The obtained results indicate that the algorithms used for the program construction were correct and suitable for the aim of the study. The above algorithms enable function under study to be presented graphically with true imaging of activity distribution, as well as numerical indices, defining extent and intensity of activity defects to calculated. (author)
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Directory of Open Access Journals (Sweden)
Irina Vladimirovna Livinskaya
2016-03-01
Full Text Available The article is aimed at presenting scientific experience of the author in composing a "Dictionary of the regional vocabulary and informal toponymes of Novosibirsk" with an anthropocentrically based lexicographical approach (offered in the works by V.V . Morkovkin as a model "from dictionary to a person" viewed as the way to overcome key challenges in building a dictionary of regional vocabulary, that is subjectivity of the authors in formation of the glossary. The four stages of the dictionary creation are characterised: 1 collecting regionally limited words in the Internet (Online Dictionary "Languages of Russian cities", forums; 2 making a survey of residents from other cities to discover regional status of the tentative entries; 3organizing a survey of Novosibirsk residents with the aim to state regional status of the words and present their meaning; 4 database analysis (about 800 units of the regionalism and informal toponymes that helped to verify the regionally limited status of the words and present contexts of their usage. The novelty of the dictionary consists in its content structure: regional vocabulary is presented as regional words (regionalism and informal toponyms. The word entries are presented in two parts – "Regional words" and "Falk toponyms". The author gives samples of the dictionary entries that illustrate the way information is presented in every part.
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Phase diagrams of the Fe-rich part of the Fe-W system under high pressure
International Nuclear Information System (INIS)
Yamane, T.; Kang, Y.S.; Minamino, Y.; Araki, H.; Hiraki, A.; Miyamoto, Y.
1995-01-01
Phase diagrams of the Fe-rich part of the Fe-W system under high pressure (1.2 and 2.2 GPa) were established by a reaction-diffusion method and calculated with thermodynamic and volumetric data. When high pressure is applied, the γ region extends and the α region contracts. As a result of increasing pressure, eutectoid and peritectoid reactions appear. (orig.)
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Directory of Open Access Journals (Sweden)
Márcia Regina Neves Guimarães
2014-05-01
Full Text Available The alignment of manufacturing strategy with the business strategy is fundamental for achieving sustainable competitive advantage. In the particular case of the automotive industry, it is verified that the production strategy of suppliers is strongly influenced by the strategy of automakers. In this context, this paper aims at presenting characteristics of the content of the production strategy of four auto parts companies besides analyzing the influence of automakers in the definition of the strategy contents.This is a descriptive and exploratory research that uses a qualitative approach and the multi-case study method. Among the main results, it was found that the prevalent competitive priority in the companies is quality followed by delivery. In the decision areas, it was noted that customers have great influence on the quality management of these companies and in the R&D activities, besides demanding frequent deliveries. Finally, it was found that auto parts companies seek to strengthen their competitive priorities by adopting criteria from suppliers for selecting and evaluating.
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Directory of Open Access Journals (Sweden)
Sergio Elías Hernández
Full Text Available To investigate regional differences in grey matter volume associated with the practice of Sahaja Yoga Meditation.Twenty three experienced practitioners of Sahaja Yoga Meditation and twenty three non-meditators matched on age, gender and education level, were scanned using structural Magnetic Resonance Imaging and their grey matter volume were compared using Voxel-Based Morphometry.Grey matter volume was larger in meditators relative to non-meditators across the whole brain. In addition, grey matter volume was larger in several predominantly right hemispheric regions: in insula, ventromedial orbitofrontal cortex, inferior temporal and parietal cortices as well as in left ventrolateral prefrontal cortex and left insula. No areas with larger grey matter volume were found in non-meditators relative to meditators.The study shows that long-term practice of Sahaja Yoga Meditation is associated with larger grey matter volume overall, and with regional enlargement in several right hemispheric cortical and subcortical brain regions that are associated with sustained attention, self-control, compassion and interoceptive perception. The increased grey matter volume in these attention and self-control mediating regions suggests use-dependent enlargement with regular practice of this meditation.
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Hernández, Sergio Elías; Suero, José; Barros, Alfonso; González-Mora, José Luis; Rubia, Katya
2016-01-01
To investigate regional differences in grey matter volume associated with the practice of Sahaja Yoga Meditation. Twenty three experienced practitioners of Sahaja Yoga Meditation and twenty three non-meditators matched on age, gender and education level, were scanned using structural Magnetic Resonance Imaging and their grey matter volume were compared using Voxel-Based Morphometry. Grey matter volume was larger in meditators relative to non-meditators across the whole brain. In addition, grey matter volume was larger in several predominantly right hemispheric regions: in insula, ventromedial orbitofrontal cortex, inferior temporal and parietal cortices as well as in left ventrolateral prefrontal cortex and left insula. No areas with larger grey matter volume were found in non-meditators relative to meditators. The study shows that long-term practice of Sahaja Yoga Meditation is associated with larger grey matter volume overall, and with regional enlargement in several right hemispheric cortical and subcortical brain regions that are associated with sustained attention, self-control, compassion and interoceptive perception. The increased grey matter volume in these attention and self-control mediating regions suggests use-dependent enlargement with regular practice of this meditation.
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Photopion production from nuclei in the energy region of the Δ resonance
International Nuclear Information System (INIS)
Tamas, G.
1979-01-01
The γD→p+p+π - and the γ 4 He→p+π+3 nucleons reactions in the energy region of the Δ resonance are studied. As a temporary conclusion, it is possible to explain the largest part of the photon-nucleus interaction for D and 4 He in the Δ resonance region by the quasi-free production and the pion and proton rescattering
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Mexico's challenges in the Asia-Pacific region: prospects in the XXI century
Directory of Open Access Journals (Sweden)
Kenia María Ramírez Meda
2016-02-01
Full Text Available The objective of the present article is to make a count of the actions taken by Mexico for its correct insertion in the Asia Pacific region and subsequently, to assess whether these strategies have been enhanced and promoted a real membership in the region. In the first part a theoretical and conceptual count of the term "region" and "regionalism" it's done. Second section deals with the question; can Asia Pacific be considered a region by addressing economic, political, social and cultural elements? Subsequently, in a third section the question; "in which region it's Mexico located?" its answered and in this way, finally we analyze if Asia Pacific is or not a mega (macro region unlikely to Mexico, where the latter could benefit if some recommendations that are seen at the end of the present work are applied.
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Regional development and regional policy
Šabić, Dejan; Vujadinović, Snežana
2017-01-01
Economic polarization is a process that is present at global, national and regional level. Economic activity is extremely spatially concentrated. Cities and developed regions use the agglomeration effect to attract labor and capital, thus achieving more favorable economic conditions than the agrarian region. Scientific research and European experiences over the past decades have contributed to the discrepancy among theorists about the causes and consequences of regional inequalities. Regional...
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Innovative regions and industrial clusters in hydrogen and fuel cell technology
International Nuclear Information System (INIS)
Madsen, Anne Nygaard; Andersen, Per Dannemand
2010-01-01
Regional governments in Europe seem to be playing an increasing role in hydrogen and fuel cell (H2FC) development. A number of regions are supporting demonstration projects and building networks among regional stakeholders to strengthen their engagement in H2FC technology. In this article, we will analyse regions that are highly engaged in H2FC activity, based on three indicators: existing hydrogen infrastructure and production sites, general innovativeness and the presence of industrial clusters with relevance for H2FC. Our finding is that regions with high activity in H2FC development are also innovative regions in general. Moreover, the article highlights some industrial clusters that create favourable conditions for regions to take part in H2FC development. Existing hydrogen infrastructure, however, seems to play only a minor role in a region's engagement. The article concludes that, while further research is needed before qualified policy implications can be drawn, an overall well-functioning regional innovation system is important in the formative phase of an H2FC innovation system.
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Basaltic volcanic episodes of the Yucca Mountain region
International Nuclear Information System (INIS)
Crowe, B.M.
1990-01-01
The purpose of this paper is to summarize briefly the distribution and geologic characteristics of basaltic volcanism in the Yucca Mountain region during the last 10--12 Ma. This interval largely postdates the major period of silicic volcanism and coincides with and postdates the timing of major extensional faulting in the region. Field and geochronologic data for the basaltic rocks define two distinct episodes. The patterns in the volume and spatial distribution of these basaltic volcanic episodes in the central and southern part of the SNVF are used as a basis for forecasting potential future volcanic activity in vicinity of Yucca Mountain. 33 refs., 2 figs
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Directory of Open Access Journals (Sweden)
Giovana F. Rossi Casali
2010-12-01
Full Text Available Este trabalho analisou o processo de formação regional do Brasil, os desequilíbrios existentes entre as regiões e as perspectivas futuras. Teve como proposta básica analisar o possível processo de convergência de renda das regiões brasileiras, utilizando o conceito de gap tecnológico. Segundo esse conceito, os desequilíbrios regionais são o resultado de diferentes taxas de desenvolvimento econômico, que, por sua vez, resultam de diferentes níveis de desenvolvimento tecnológico, os quais, por fim, são consequências de condições históricas, sociais e culturais específicas de cada região. Dessa forma, pressupôs-se a existência de relação positiva entre nível de desenvolvimento tecnológico, dependência tecnológica, dependência econômica, nível de desenvolvimento econômico e convergência de renda. Os resultados mostram que, em relação à possibilidade de as regiões e os estados menos desenvolvidos realizarem o catching up com aqueles mais desenvolvidos, as variáveis que representam tanto a geração quanto a apropriação de novas tecnologias são significativas e diretamente relacionadas com o produto. Dessa forma, pode-se afirmar que o catching up seria possível caso houvesse um maior investimento no processo de desenvolvimento e apropriação de novas tecnologias por parte dos governos regionais.This research developed an analysis on the regional imbalances at the Brazilian economy, the historic formation of the regions and perspectives. As a result of the distinctive courses followed by each region, an economical concentration process occurs in the Southeast. In this sense, this study intended to analyze the possible process of the Brazilian regional formation, using the concept of technological gap. The result show that, in relation to the possibilities of the regions and states that are less developed to accomplish the catching up with those that are more developed, the variables that represent generation
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Stratigraphy of the south polar region of Ganymede
Dehon, R. A.
1987-01-01
A preliminary assessment is made of the stratigraphy and geology in the south polar region of the Jovian satellite, Ganymede. Geologic mapping is based on inspection of Voyager images and compilation on an airbrush base map at a scale of 1:5M. Illumination and resolution vary greatly in the region. Approximately half of the quadripole is beyond the terminator. Low angle illumination over a large part of the area precludes distinction of some units by albedo characteristics. Several types of grooved terrain and groove related terrain occur in the southern polar region. Grooves typically occur in straight to curvilinear sets or lanes. Bright lanes and grooved lanes intersect at high angles outlining polygons of dark cratered terrain. Groove sets exhibit a range of ages as shown by superposition or truncation and by crater superposition ages.
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Regional differences in commuting activities of inhabitants in the Tokyo metropolitan suburb
Directory of Open Access Journals (Sweden)
Masaki Kawase
2004-12-01
Full Text Available The purpose of this study is to elucidate gender differences and regional differences of co-mmuting activities by inhabitants in Japanese metropolitan suburbs. I found the different parts by districts in the metropolitan suburb. Regional factors cause gender differences in commuting activities and result in regional differences: In residential areas, inhabitants who work in metropolitan centers occupy much of the population. In older built-up areas, there are many “local” persons. In rural areas, motorization is progressing because access to rail-roads has been inconvenient. These regional factors influence the behavioral characteristics of commuting by married men, married women, never married men and never married women.
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Basaldua, Raul Oscar; Moreno, Oscar Alberto
1971-01-01
This paper is part of a larger research project on the decisional structure of regionalized countries, which the authors are conducting at the Instituto Torcuato Di Tella with the Arq. Jorge Hardoy. (Editor)
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On the absolute stability regions corresponding to partial sums of the exponential function
Ketcheson, David I.
2013-12-03
Certain numerical methods for initial value problems have as stability function the nth partial sum of the exponential function. We study the stability region, i.e., the set in the complex plane over which the nth partial sum has at most unit modulus. It is known that the asymptotic shape of the part of the stability region in the left half-plane is a semi-disk. We quantify this by providing disks that enclose or are enclosed by the stability region or its left half-plane part. The radius of the smallest disk centered at the origin that contains the stability region (or its portion in the left half-plane) is determined for 1 n 20. Bounds on such radii are proved for n 2; these bounds are shown to be optimal in the limit n ! +1. We prove that the stability region and its complement, restricted to the imaginary axis, consist of alternating intervals of length tending to , as n ! 1. Finally, we prove that a semi-disk in the left half-plane with vertical boundary being the imaginary axis and centered at the origin is included in the stability region if and only if n 0 mod 4 or n 3 mod 4. The maximal radii of such semi-disks are exactly determined for 1 n 20.
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Small part ultrasound in childhood and adolescence
Energy Technology Data Exchange (ETDEWEB)
Wunsch, R., E-mail: R.Wunsch@kinderklinik-datteln.de [Department of Pediatric Radiology, Vestic Children' s Hospital Datteln, University of Witten/Herdecke, Dr.-Friedrich-Steiner-Strasse 5, D-45711 Datteln (Germany); Rohden, L. von, E-mail: l.vonrohden@gmx.de [Department of Pediatric Radiology, Otto-von-Guericke-University Magdeburg, Klinik f. Radiologie und Nuklearmedizin – Kinderradiologie, Leipziger Straße 44, D-39120 Magdeburg (Germany); Cleaveland, R. [Department of Pediatric Radiology, Vestic Children' s Hospital Datteln, University of Witten/Herdecke, Dr.-Friedrich-Steiner-Strasse 5, D-45711 Datteln (Germany); Aumann, V., E-mail: volker.aumann@med.ovgu.de [Department of Pediatric Haematology and Oncology, Otto-von-Guericke-University Magdeburg, Universitätskinderklinik (H 10), Pädiatrische Hämatologie und Onkologie, Leipziger Straße 44, D-39120 Magdeburg (Germany)
2014-09-15
Small-part sonography refers to the display of small, near-surface structures using high-frequency linear array transducers. Traditional applications for small part ultrasound imaging include visualization and differential diagnostic evaluation in unclear superficial bodily structures with solid, liquid and mixed texture, as well as similar structures in nearly superficial organs such as the thyroid glands and the testes. Furthermore indications in the head and neck regions are the assessment of the outer CSF spaces in infants, the sonography of the orbit, the sonography of the walls of the large neck vessels, the visualization of superficially situated lymph nodes and neoplasms. Clinical evidence concludes that sonography, having of all imaging modalities the highest spatial resolution in the millimeter- and micrometer range (100–1000 μm), can be considered the best suited technique for examining superficial pathological formations and near-surface organs. In addition, it delivers important information about characteristic, often pathognomonic tissue architecture in pathological processes.
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Small part ultrasound in childhood and adolescence
International Nuclear Information System (INIS)
Wunsch, R.; Rohden, L. von; Cleaveland, R.; Aumann, V.
2014-01-01
Small-part sonography refers to the display of small, near-surface structures using high-frequency linear array transducers. Traditional applications for small part ultrasound imaging include visualization and differential diagnostic evaluation in unclear superficial bodily structures with solid, liquid and mixed texture, as well as similar structures in nearly superficial organs such as the thyroid glands and the testes. Furthermore indications in the head and neck regions are the assessment of the outer CSF spaces in infants, the sonography of the orbit, the sonography of the walls of the large neck vessels, the visualization of superficially situated lymph nodes and neoplasms. Clinical evidence concludes that sonography, having of all imaging modalities the highest spatial resolution in the millimeter- and micrometer range (100–1000 μm), can be considered the best suited technique for examining superficial pathological formations and near-surface organs. In addition, it delivers important information about characteristic, often pathognomonic tissue architecture in pathological processes
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The Mid America Heart Institute: part II.
McCallister, Ben D; Steinhaus, David M
2003-01-01
The Mid America Heart Institute (MAHI) is one of the first and largest hospitals developed and designed specifically for cardiovascular care. The MAHI hybrid model, which is a partnership between the not-for-profit Saint Luke's Health System, an independent academic medical center, and a private practice physician group, has been extremely successful in providing high-quality patient care as well as developing strong educational and research programs. The Heart Institute has been the leader in providing cardiovascular care in the Kansas City region since its inception in 1975. Although challenges in the future are substantial, it is felt that the MAHI is in an excellent position to deal with the serious issues in health care because of the Heart Institute, its facility, organization, administration, dedicated medical and support staff, and its unique business model of physician management. In part I, the authors described the background and infrastructure of the Heart Institute. In part II, cardiovascular research and benefits of physician management are addressed.