Opening the SMS platform to users : Deliverable D7.2 - RISIS project

NARCIS (Netherlands)

van den Besselaar, P.A.A.; Khalili, A.; de Graaf, K.A.; Idrissou, O.A.K.; van Harmelen, Frank

2017-01-01

In this deliverable we describe the SMS (Semantically Mapping Science) data integration platform (http://sms.risis.eu), the technical core within the RISIS data infrastructure for Science, Technology and Innovation Studies (STI). The aim of the platform is to produce richer data to be used in social

Evolution and development of a deliverability improvement program for gas storage

International Nuclear Information System (INIS)

Maddox, T.D.; Sikorski, D.L.

1994-01-01

With the implementation in November 1993 of FERC Order 636, the responsibilities and contractual obligations for a Gas Transmission Company operating Gas Storage have changed. Among these responsibilities is the ability to deliver gas from storage in a timely manner as specified by gas storage contracts. To ensure that their deliverability obligations are met, a program has been implemented to review well performance and to re-work wells where deliverability can economically be improved. This program is aimed at maintaining or improving deliverability from wells and monitoring their future performance. Re-working existing wells has proven to be an economically successful method of maintaining deliverability compared to drilling new wells to meet this purpose. Re-working can be broken into two groups of wells: wells that have mechanical problems that need to be corrected or wells that need some type of stimulation treatment. In developing a rework program, several things need to be addressed such as: a candidate recognition program, the design of the work to be performed, execution of that work, and the evaluation of the results obtained along with the economics. The Deliverability Improvement Program is in its third year. It has developed from a small pilot program to a substantial part of normal storage activities. The purpose of this paper is to review the processes used to find candidates to work on and an evaluation of work performed

How the NDA Provides Transparency and Visibility of the Technical Deliverability of the R and D Programme - 13303

International Nuclear Information System (INIS)

Seed, Ian; James, Paula; Brownridge, Melanie; McMinn, Mervin

2013-01-01

The Nuclear Decommissioning Authority (NDA) was created under the UK Energy Act 2004 to ensure the UK historic civil public sector nuclear legacy sites are decommissioned safely, securely, cost effectively and in ways that protect the environment. The delivery will involve carrying out many unique projects within a high hazard environment requiring the very highest standards in safety, security and environmental management. Unique problems require unique solutions and there is a substantial amount of research and development required for each project. The NDA's R and D strategic objective is to ensure that delivery of the NDA's mission is technically underpinned by sufficient and appropriate research and development. This drives a requirement to provide transparency and visibility of the technical deliverability of the programme through the technical baseline and accompanying research and development requirements. The NDA need to have confidence in the technical deliverability of the Site License Companies (SLCs) plans, provide overall visibility of R and D across the NDA Estate and ensure that appropriate R and D is being carried out in a timely manner. They need to identify where coordinated R and D programmes may be advantageous as a result of common needs, risks and opportunities and ensure key R and D needs across NDA are identified, prioritised and work programmes are costed and scheduled in the Lifetime Plans for individual sites and SLCs. Evidence of the Site License Company's approach and their corresponding technical underpinning programmes is achieved through submission of a number of outputs collectively known as TBuRDs (Technical Baseline and Underpinning Research and Development Requirements). This paper is a summary of the information generated by an independent review of those TBuRDs. It highlights some of the key messages, synergies and common R and D activities across the estate. It demonstrates the value of a consistent approach to collecting R

Deliverable 1.2.7: Cross-cultural benefit segmentation of consumers

NARCIS (Netherlands)

Reinders, M.J.; Onwezen, M.C.; Sijtsema, S.J.; Zimmermann, K.L.; Berg, van den I.; Jasiulewicz, A.; Guardia, M.D.; Guerrero, L.

2010-01-01

The present report, deliverable D.1.2.7, gives a final view of the work done in ISAFruit Work Package (WP) 1.2. Average Europe fruit consumption is below the recommended level and moreover the consumption level is still decreasing in Europe. A large survey was carried out in four European countries

The Impact of Debt Limitations and Referenda Requirements on the Cost of School District Bond Issues

Science.gov (United States)

Harris, Mary H.; Munley, Vincent G.

2011-01-01

One distinction between the markets for corporate and municipal bonds involves institutional constraints that apply to some municipal bond issues. This research focuses on how public finance institutions, in particular explicit debt limits and referenda requirements, affect the borrowing cost of individual school district bond issues. The…

Bioclim Deliverable D7: continuous climate evolution scenarios over western Europe (1000 km scale)

International Nuclear Information System (INIS)

2003-01-01

The overall aim of BIOCLIM is to assess the possible long term impacts due to climate change on the safety of radioactive waste repositories in deep formations. This aim is addressed through the following specific objectives: - Development of practical and innovative strategies for representing sequential climatic changes to the geosphere-biosphere system for existing sites over central Europe, addressing the timescale of one million years, which is relevant to the geological disposal of radioactive waste. - Exploration and evaluation of the potential effects of climate change on the nature of the biosphere systems used to assess the environmental impact. - Dissemination of information on the new methodologies and the results obtained from the project among the international waste management community for use in performance assessments of potential or planned radioactive waste repositories. A key point of the project is therefore to develop strategies for representing sequential long-term climatic changes by addressing time scales of relevance to geological disposal of solid radioactive wastes. The integrated strategy, which first step is described in this deliverable (D7), consists of building an integrated, dynamic climate model, to represent all the known important mechanisms for long term climatic variations. The time-dependent results will then be interpreted in terms of regional climate using rule-based and statistical down-scaling approaches. Therefore, the continuous simulation of the climate evolution of the next 200 000 years selected for study is a major objective of the BIOCLIM project. This requires models that account for the simultaneous evolution of the atmosphere, biosphere, land-ice and the ocean. To be able to perform several 200 000-yearlong transient climate simulations, the models have to include all these components, but also need to be simple enough to run fast. Therefore, climate models of intermediate complexity have been chosen to

Evaluation, testing and application of participatory approaches in the Czech Republic. Guidelines on approaches to siting a deep repository. Deliverable D21

International Nuclear Information System (INIS)

Vojtechova, Hana

2009-10-01

Based on the review of experiences in SEA and EIA in the Czech Republic summarized in Deliverable No.3 and the testing of novel participatory and dialogue approaches summarized in Deliverables No.7, 11 and 12 in this report a model for the siting process specifically in the Czech Republic, that takes into account the need for transparency and interaction with the public, within the framework of legal requirements is outlined. Lessons learnt are summarised and a road map specified. The guidelines / recommendations in this report are proposed based on mapping the situation in the Czech Republic and experience gained in connection with the testing and application of novel participatory approaches and dialogue, but many of them are of general validity and can be applied in other countries outside the Czech Republic. This reports links directly to Work package 6, where general guidelines for participation and transparency, reflecting institutional and cultural differences, are given - Deliverable No.22

A Cognitive Model of the Effects of Linking Political Referenda to Salient Social Issues: A Lottery Will Fund Education, But Casinos Will Cause Crime?

Science.gov (United States)

Ferguson, M. A.; And Others

Contrasting a party identification model with a rational decision making model, a cognitive model predicts voter intent on two referenda: (1) an amendment to permit a state lottery; and (2) an amendment to permit residents of each county to vote on whether to permit casino gambling. Supporters of the lottery amendment attempt to strongly link it…

Natural Gas Deliverability Task Force report: A joint FERC/DOE project

International Nuclear Information System (INIS)

1992-09-01

The purpose of the FERC/DOE Natural Gas Deliverability Task Force Report was threefold: (1) to review current deliverability data for utility, accuracy, and timeliness; (2) to identify mechanisms for closing significant gaps in information resulting from changing market structures; and (3) to ensure that technologies are available to meet the needs of the emerging, competitive natural gas industry

Modeling & Simulation Education for the Acquisition and T&E Workforce: FY07 Deliverable Package

National Research Council Canada - National Science Library

Olwell, David H; Johnson, Jean; Few, Stephanie; Didoszak, Jarema M

2007-01-01

This technical report presents the deliverables for calendar year 2007 for the "Educating the Modeling and Simulation Workforce" project performed for the DoD Modeling and Simulation Steering Committee...

Short-term Canadian natural gas deliverability 2005-2007 : an energy market assessment

International Nuclear Information System (INIS)

2005-10-01

This document examined the factors that influence gas supply in the short-term and presented an outlook for deliverability from 2005 to 2007. Recent trends in the production characteristics of the Western Canada Sedimentary Basin (WCSB) and the east coast offshore provide a better understanding of the short-term gas supply situation. High natural gas prices have resulted in record levels of drilling in Canada's natural gas exploration and production industry. Drilling levels are expected to remain high as industry will continue to maximize efforts to increase production. However, due to the maturity of the WCSB, the effort will result in only a modest increase in production over the next 2 years. The low decline characteristics of natural gas from coal (NGC) wells will have a stabilizing effect on WCSB deliverability over the long-term. It was noted that approximately 98 per cent of Canadian gas is produced from the WCSB with Alberta accounting for 80 per cent of the output. This assessment provided separate deliverability estimates for conventional gas in the WCSB, NGC, and offshore Nova Scotia. The contribution from offshore Nova Scotia will likely remain in the range of 10 to 11 million cubic metres per day until late 2006, and rise to an average of 13 million cubic metres per day in 2007 with added compression. It was concluded that Canadian deliverability will increase slightly through an increase in drilling activity. It was also noted that the province of Alberta and the petroleum industry are addressing the issue of drilling density, access to resources, noise and other environmental aspects of the expected increase in NGC activity. 3 tabs., 16 figs., 3 appendices

Deliverable D.8.4. Social data visualization and navigation services -3rd Year Update-

NARCIS (Netherlands)

Bitter-Rijpkema, Marlies; Brouns, Francis; Drachsler, Hendrik; Fazeli, Soude; Sanchez-Alonso, Salvador; Rajabi, Enayat; Kolovou, Lamprini

2015-01-01

Within the Open Discovery Space our study (T.8.4) focused on ”Enhanced Social Data Visualization & Navigation Services. This deliverable provides the prototype report regarding the deployment of adapted visualization and navigation services to be integrated in the ODS Social Data Management Layer.

Participation with a Punch: Community Referenda on Dam Projects and the Right to Free, Prior, and Informed Consent to Development

Directory of Open Access Journals (Sweden)

Brant McGee

2010-06-01

Full Text Available The 2000 Report of the World Commission on Dams (WCD found that dams can threaten the resources that provide the basis for indigenous and other peoples’ culture, religion, subsistence, social and family structure – and their very existence, through forced relocation – and lead to ecosystem impacts harmful to agriculture, animals and fish. The WCD recommended the effective participation of potentially impacted local people in decisions regarding dam construction. The international right to free, prior, and informed consent (FPIC accorded to indigenous peoples promises not only the opportunity to participate in decisions affecting their lands and livelihoods but to stop unwanted development by refusing consent as well. The newly developed concept of community referenda, held in areas potentially impacted by development projects, provides an accurate measure of the position of local voters on the proposed project through a democratic process that discourages violence, promotes fair and informed debate, and provides an avenue for communities to express their consent or refusal of a specific project. The legal basis, practical and political implications, and Latin American examples of community referenda are explored as a means of implementing the critical goal of the principle of FPIC, the expression of community will and its conclusive impact on development decision-making.

QUEST2: Release 1: Project plan deliverable set

International Nuclear Information System (INIS)

Braaten, F.D.

1995-01-01

This Project Management Plan combines the project management deliverables from the P+ methodology which are applicable to Release 1 of the QUEST2 work. This consolidation reflects discussions with WHC QA regarding an appropriate method for ensuring that P+ deliverables fulfill the intent of WHC-CM-3-10 and QR-19

„CONSTITUTIONAL COURT OF THE REPUBLIC OF CROATIA AND CITIZEN-INITIATED REFERENDA IN THE 2013-2015 PERIOD: ANALYSIS AND PROPOSALS“

Directory of Open Access Journals (Sweden)

Ana Horvat Vuković

2016-01-01

Full Text Available The author analyzes the decisions of the Constitutional Court of the Republic of Croatia regarding citizen-initiated referenda, adopted in the period between 2013 and 2015. From the referendum on the definition of marriage, through the Court’s ruling on the referendum on the Cyrillic script, to the most recent cases dealing with outsourcing in the public administration and monetization of Croatian highways, she outlines a trend of growing limitations to the popular referendum institute. Paying particular attention to the decision on outsourcing from 8 April 2015, she highlights the problem areas of constitutional jurisprudence and suggests their corrections. Regarding the cogent nature of the obligation to substantiate the initiative with a statement of circumstances that provoked it, she holds that question as falling in the area of legislative discretion. Regarding the “premature nature” of an initiative, she argues that the Court may not tie its destiny to the existence of a Government’s program not yet formalized as a concrete bill. It also cannot clairvoyantly assess the impact of a referendum on the system of public finances. In balancing the right to referendum with budgetary stability, it may only take account of foreseeable consequences and measurable data, and withhold the right to referendum only in cases of decisions whose impact on the state’s fiscal stability would violate the guarantees of the Constitution’s Arts.3 and 16. Finally, she concludes on the impermissibility of applying stricter scrutiny to citizen-initiated referenda then to identical texts adopted by the Croatian Parliament. She holds such escalation of standards of review untenable in the light of a grammatical and teleological interpretation of the Constitution, as well as due to its punitive effect.

Capabilities and costs for ancillary services provision by wind power plants. Deliverable D 3.1

DEFF Research Database (Denmark)

Faiella, Mariano; Hennig, Tobias; Cutululis, Nicolaos Antonio

This report is the deliverable of the third work package of the REserviceS project and describes the technical options and related costs for the provision of ancillary services specifically from wind energy technologies. It is focused on the set of ancillary services defined in the previous work...

Summary of FY 17 Assessments Sandia National Laboratories: Evaluation of FY16 SNL FCT M2 Milestone Deliverables

Energy Technology Data Exchange (ETDEWEB)

Appel, Gordon John

2017-03-01

This report is the milestone deliverable M4FT-17SN111102091 “Summary of Assessments Performed FY17 by SNL QA POC” for work package FT-17SN11110209 titled “Quality Assurance – SNL”. This report summarizes the FY17 assessment performed on Fuel Cycle Technologies / Spent Fuel and Waste Disposition efforts.

Project Turnover Deliverables for the SY Farm Enraf Annulus Leak Detectors

International Nuclear Information System (INIS)

SCAIEF, C.C.

2000-01-01

This document identifies the deliverables that ensure the end user of the SY Farm Enraf Annulus Leak Detectors (ALD) has all the documentation and training required for operating and maintaining the new system. All deliverable items checked on the Acceptance For Beneficial Use (ABU) form have been completed and are available to the end user. This document was written as required by HNF-IP-0842, Volume IV section 3.12 Acceptance of Structures, Systems, and Components for Beneficial Use. This document applies to the deliverable documentation required to operate and maintain the SY Farm Enraf ALD System. Appendix A provides a copy of the ABU form as listed in the appendix of TWR-4092, Engineering Task Plan for the New SY Farm Annulus Leak Detectors. This document attests that all required deliverable items checked on the ABU have been completed and are available to the end user

Deliverable 2.1

DEFF Research Database (Denmark)

Nunez, Heilyn Camacho; Jonasen, Tanja Svarre; Skov, Mette

2016-01-01

This deliverable describes in detail the problem based learning (PBL) approach and its potential for open data education. The first section provides a theoretical description of PBL with the purpose of offering a platform for the design of open data learning activities. Section two describes the ...... the current practice of open data training within the ODEdu partners along with international initiatives. The last section provides pedagogical recommendations for the process of designing the open data courses and online platform aimed at in WP3....

Virtual Enterprise Reference Architecture and Methodology (VERAM), Joint D41/D43 deliverable of GLOBEMEN

DEFF Research Database (Denmark)

Tølle, Martin; Zwegers, Arian; Vesterager, Johan

2003-01-01

. IMS Globemen is an inter-regional project aiming to develop methods, tools and architectures to support inter-enterprise operations in one-of-kind industries, in different lifecycle phases. This deliverable describes an architectural framework VERAM including a description/elaboration of its elements......-of-a-kind-production”, the concept of the Virtual Enterprise (VE) and the Virtual Enterprise Reference Architecture (VERA) developed in GLOBEMEN. - In Chapter 4 a so-called life history example is presented to give a possible scenario about how an enterprise network could evolve over time, and to point out the need for preparing...... and setting up networks and VEs. The life history example in Chapter 4 highlights the potential for preparing and reusing existing knowledge related to enterprise networks and VEs. - As a means to structure relevant knowledge GLOBEMEN developed the VERAM (Virtual Enterprise Reference Architecture...

Fluctuations and predictability of wind and hydropower. Deliverable 2.1

DEFF Research Database (Denmark)

Giebel, Gregor; Holttinen, H.; Söder, L.

2004-01-01

The report forms the deliverable D2.1 of the EU supported project Wind Power Integration in a Liberalised Electricity Market (WILMAR). The handling and generation of the necessary wind and hydro time series for the project’s power system planningsimulation model is described. The wind power...... and the hydro power time series on hourly basis are generated on basis of real data for all the geographical regions included in the analysis in order to realistically represent the various correlations intime and displacement. Models have been developed to generate various realistic future time series based...

Deliverable navigation for multicriteria IMRT treatment planning by combining shared and individual apertures

International Nuclear Information System (INIS)

Fredriksson, Albin; Bokrantz, Rasmus

2013-01-01

We consider the problem of deliverable Pareto surface navigation for step-and-shoot intensity-modulated radiation therapy. This problem amounts to calculation of a collection of treatment plans with the property that convex combinations of plans are directly deliverable. Previous methods for deliverable navigation impose restrictions on the number of apertures of the individual plans, or require that all treatment plans have identical apertures. We introduce simultaneous direct step-and-shoot optimization of multiple plans subject to constraints that some of the apertures must be identical across all plans. This method generalizes previous methods for deliverable navigation to allow for treatment plans with some apertures from a collective pool and some apertures that are individual. The method can also be used as a post-processing step to previous methods for deliverable navigation in order to improve upon their plans. By applying the method to subsets of plans in the collection representing the Pareto set, we show how it can enable convergence toward the unrestricted (non-navigable) Pareto set where all apertures are individual. (paper)

Assessment Report Sandia National Laboratories Fuel Cycle Technologies Quality Assurance Evaluation of FY15 SNL FCT M2 Milestone Deliverables

International Nuclear Information System (INIS)

Appel, Gordon John

2016-01-01

Sandia National Laboratories (SNL) Fuel Cycle Technologies (FCT) program activities are conducted in accordance with FCT Quality Assurance Program Document (FCT-QAPD) requirements. The FCT-QAPD interfaces with SNL approved Quality Assurance Program Description (SNL-QAPD) as explained in the Sandia National Laboratories QA Program Interface Document for FCT Activities (Interface Document). This plan describes SNL's FY16 assessment of SNL's FY15 FCT M2 milestone deliverable's compliance with program QA requirements, including SNL R&A requirements. The assessment is intended to confirm that SNL's FY15 milestone deliverables contain the appropriate authenticated review documentation and that there is a copy marked with SNL R&A numbers.

Assessment Report Sandia National Laboratories Fuel Cycle Technologies Quality Assurance Evaluation of FY15 SNL FCT M2 Milestone Deliverables

Energy Technology Data Exchange (ETDEWEB)

Appel, Gordon John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2016-05-01

Sandia National Laboratories (SNL) Fuel Cycle Technologies (FCT) program activities are conducted in accordance with FCT Quality Assurance Program Document (FCT-QAPD) requirements. The FCT-QAPD interfaces with SNL approved Quality Assurance Program Description (SNL-QAPD) as explained in the Sandia National Laboratories QA Program Interface Document for FCT Activities (Interface Document). This plan describes SNL's FY16 assessment of SNL's FY15 FCT M2 milestone deliverable's compliance with program QA requirements, including SNL R&A requirements. The assessment is intended to confirm that SNL's FY15 milestone deliverables contain the appropriate authenticated review documentation and that there is a copy marked with SNL R&A numbers.

Load Composition Model Workflow (BPA TIP-371 Deliverable 1A)

Energy Technology Data Exchange (ETDEWEB)

Chassin, David P.; Cezar, Gustavo V.; /SLAC

2017-07-17

This project is funded under Bonneville Power Administration (BPA) Strategic Partnership Project (SPP) 17-005 between BPA and SLAC National Accelerator Laboratory. The project in a BPA Technology Improvement Project (TIP) that builds on and validates the Composite Load Model developed by the Western Electric Coordinating Council's (WECC) Load Modeling Task Force (LMTF). The composite load model is used by the WECC Modeling and Validation Work Group to study the stability and security of the western electricity interconnection. The work includes development of load composition data sets, collection of load disturbance data, and model development and validation. This work supports reliable and economic operation of the power system. This report was produced for Deliverable 1A of the BPA TIP-371 Project entitled \\TIP 371: Advancing the Load Composition Model". The deliverable documents the proposed work ow for the Composite Load Model, which provides the basis for the instrumentation, data acquisition, analysis and data dissemination activities addressed by later phases of the project.

The iTREN-2030 reference scenario until 2030. Deliverable D4

Energy Technology Data Exchange (ETDEWEB)

Fiorello, Davide; De Stasio, Claudia; Koehler, Jonathan; Kraft, Markus; Netwon, Sean; Purwanto, Joko; Schade, Burkhard; Schade, Wolfgang; Szimba, Eckhard

2009-07-01

The basic objective of iTREN-2030 is to extend the forecasting and assessment capabilities of the TRANS-TOOLS transport model to the new policy issues arising from the technology, environment and energy fields. This is achieved by couplin the TRANS-TOOLS model with three other models, ASTRA, POLES and TREMOVE covering these new policy issues. The TRANS-TOOLS transport network model has been developed to constitute the reference tool for supporting transport policy in the EU and currently is being developed in several European projects. The scenario set-up to be developed in iTREN-2030 has been modified, so that the projects develops a reference scenario and an integrated scenario. For the reference scenario, the three other modelling tools are harmonised with TRANS-TOOLS and made consistent with each other. This results in a coherent scenario for Europe until 2030 for technology, transport, energy, environment and economic development. The integrated scenario will consider the changing framework conditions until 2030, inparticular the policy pressure coming from climate policy and the increasing scarcity of fossil fuels as well as the impact of the financial and economic crisis. Within the iTREN-2030 project, the overall objective of Work Package 4 (WP4) producing tis deliverable is to develop the reference scenario for the quantitative projections using the four modelling tools involved in the project. The main aims of WP4 are to (a) define a consistent framework for using the different tools in an integrated way; (b) calibrate models with exchanged input to a coherent joint reference; (c) implement external input from WP3 and running models for projections; (d) produce output procedures and templates to facilitate assessment in WP5.

SiteChar. Characterisation of European CO2 storage. Deliverable D8.1. Qualitative and quantitative social site characterisations

Energy Technology Data Exchange (ETDEWEB)

Brunsting, S.; Pol, M.; Paukovic, M. [ECN Policy Studies, Energy research Centre of the Netherlands ECN, Amsterdam (Netherlands); Kaiser, M.; Zimmer, R. [Unabhaengiges Institut fuer Umweltfragen UfU, Berlin (Germany); Shackley, S.; Mabon, L. [Scottish Carbon Capture and Storage SCCS, Edinburg, Scotland (United Kingdom); Hepplewhite, F.; Loveridge, R. [Energy Markets Unit, Scottish Government, Edinburg, Scotland (United Kingdom); Mazurowski, M.; Polak-Osiniak, D. [Polish Oil and Gas Company PGNiG, Warszawa (Poland); Rybicki, C. [AGH University of Science and Technology, Krakow (Poland)

2012-10-15

At local level, public support has proven crucial to the implementation of CO2 capture and storage (CCS) demonstration projects. Whereas no method exists to guarantee public acceptability of any project, a constructive stakeholder engagement process does increase the likelihood thereof. Social site characterisation can be used as an instrument to explore, plan and evaluate a process of active and constructive local stakeholder engagement in a prospective CCS project as a parallel activity to technical site characterisation. It roughly consists of a formative research phase to get acquainted with the area followed by a series of public information and engagement activities. This deliverable presents results from the first phase for the social site characterisations of a prospective CCS site in Poland (onshore) and the UK (offshore), using qualitative as well as quantitative research methods, as a first step to planning of local public engagement activities and evaluation of these activities that will be undertaken by this consortium at both sites in the near future. Although the term social site characterisation actually refers to the entire process of formative research and subsequent public outreach, and hence to the complete package of awareness work undertaken as part of SiteChar, in the present deliverable the term only refers to the formative research activities as undertaken up to now and as described in this deliverable. The qualitative part of the social site characterisation consisted of (1) a description of relevant social site characteristics such as local history; (2) interviews with relevant local stakeholders; (3) a media analysis of local newspapers. The quantitative part of the social site characterisation consisted of surveys using representative samples to characterise the local population in terms of awareness, knowledge and perceptions of CCS, felt involvement in decision making, extent of local activism, level of trust in representatives and

20 CFR 638.812 - State and local taxation of Job Corps deliverers.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false State and local taxation of Job Corps deliverers. 638.812 Section 638.812 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF... § 638.812 State and local taxation of Job Corps deliverers. The Act provides that transactions conducted...

Stereochemistry of 16a-Hydroxyfriedelin and 3-Oxo-16-methylfriedel-16-ene Established by 2D NMR Spectroscopy

Directory of Open Access Journals (Sweden)

Vagner Fernandes Knupp

2009-02-01

Full Text Available Friedelin (1, 3b-friedelinol (2, 28-hydroxyfriedelin (3, 16a-hydroxyfriedelin (4, 30-hydroxyfriedelin (5 and 16a,28-dihydroxyfriedelin (6 were isolated through fractionation of the hexane extract obtained from branches of Salacia elliptica. After a week in CDCl3 solution, 16a-hydroxyfriedelin (4 reacted turning into 3-oxo-16-methylfriedel-16-ene (7. This is the first report of a dehydration followed by a Nametkin rearrangement of a pentacyclic triterpene in CDCl3 solution occurring in the NMR tube. These seven pentacyclic triterpenes was identified through NMR spectroscopy and the stereochemistry of compound 4 and 7 was established by 2D NMR (NOESY spectroscopy and mass spectrometry (GC-MS. It is also the first time that all the 13C-NMR and 2D NMR spectral data are reported for compounds 4 and 7.

Deliverable 1.2.1 Market Analysis and Business Plan

DEFF Research Database (Denmark)

Peterson, Carrie Beth

2009-01-01

Deliverable 1.2.1 - Market Analysis and Business Plan The main objective of this deliverable is to provide a short overview of 4 communities involved in the pilots, envisaged type of solutions and architectures to be deployed (chapter 2) and market analysis at regional level (chapter 3......) with related business cases. The Market analysis will provide an overview of market requirements, current status and opportunities for the pilot service that will be provided in the context of ISISEMD. This will be realised by performing detailed studies on various sources. Proposals for business modelling...... and business cases (chapter 4) will rely on the concept of value chains. Value chains typically consist of several providers, which together produce a complex product or service....

Southwest British Columbia natural gas supply and deliverability: Discussion paper

International Nuclear Information System (INIS)

1994-02-01

A review is presented of energy in British Columbia, the role of natural gas, and options available to enhance gas supply security in the province's most densely populated area, the southwest. British Columbia has abundant natural gas supplies, and production exceeds domestic demand. In 1992, natural gas supplied ca 25% of total provincial end-use energy requirements, but this share is expected to rise to 30% by 2015. Although some say that the province's natural gas production and transmission system should serve only domestic needs, this would have significant negative impacts. Domestic gas supply policy allows gas consumers to contract their own supplies, but contract security is required. Provincial guidelines allow demand-side programs to compete with supply sources to ensure that the resource profile is achieved at least cost. In the southwest, natural gas demand is projected to increase from 189 PJ in 1991 to 262 PJ by 2005. Most gas supplied to this region comes from northeast British Columbia through pipelines that are generally fully contracted. Short-term deliverability can be a problem, especially in peak winter demand periods. The gas industry's contingency plans for shortages are outlined and alternatives to enhance deliverability to the southwest are assessed, including storage, expansion of the pipeline system, supply curtailment, and peaking supply contracts. Aspects of provincial natural gas planning are discussed, including security of supply and deliverability, economic and environmental impacts, consumer costs, safety, and the public interest. A least-cost option for enhancing deliverability (underground storage and an additional liquefied natural gas plant) is estimated to cost consumers $3.69/GJ over 20 years. 9 figs., 1 tab

Bioclim deliverable D8a: development of the rule-based down-scaling methodology for BIOCLIM Work-package 3

International Nuclear Information System (INIS)

2003-01-01

The BIOCLIM project on modelling sequential Biosphere systems under Climate change for radioactive waste disposal is part of the EURATOM fifth European framework programme. The project was launched in October 2000 for a three-year period. The project aims at providing a scientific basis and practical methodology for assessing the possible long term impacts on the safety of radioactive waste repositories in deep formations due to climate and environmental change. Five work packages (WP) have been identified to fulfill the project objectives. One of the tasks of BIOCLIM WP3 was to develop a rule-based approach for down-scaling from the MoBidiC model of intermediate complexity in order to provide consistent estimates of monthly temperature and precipitation for the specific regions of interest to BIOCLIM (Central Spain, Central England and Northeast France, together with Germany and the Czech Republic). A statistical down-scaling methodology has been developed by Philippe Marbaix of CEA/LSCE for use with the second climate model of intermediate complexity used in BIOCLIM - CLIMBER-GREMLINS. The rule-based methodology assigns climate states or classes to a point on the time continuum of a region according to a combination of simple threshold values which can be determined from the coarse scale climate model. Once climate states or classes have been defined, monthly temperature and precipitation climatologies are constructed using analogue stations identified from a data base of present-day climate observations. The most appropriate climate classification for BIOCLIM purposes is the Koeppen/Trewartha scheme. This scheme has the advantage of being empirical, but only requires monthly averages of temperature and precipitation as input variables. Section 2 of this deliverable (D8a) outline how each of the eight methodological steps have been undertaken for each of the three main BIOCLIM study regions (Central England, Northeast France and Central Spain) using Mo

Conclusions and summaries of feed-back comments from participating countries. Deliverable D18

International Nuclear Information System (INIS)

Drottz Sjoeberg, Britt-Marie; Richardson, Phil; Pritrsky, Jozef

2009-12-01

Deliverable 18 is focused on the principal components of risk communication strategies and based on actual experiences from different cultural settings in relation to nuclear waste management (NWM) issues. Essentially it describes how the ideas were presented and developed within the 3rd year of the ARGONA project, in sub-workpackage 4.1. The intention of this work was to delineate good risk communication approaches across national borders, as well as to specify the circumstances that require more specific and unique national or group considerations. Our aim was to provide an in-depth analysis of societal patterns and trends regarding the management of nuclear wastes on the basis of a number of individual participants' understanding and open discussion of the issue between themselves and across the heterogeneous groups represented. To meet these goals we involved a number of stakeholders from ARGONA participating countries (UK, Sweden, Slovakia, Czech Republic) in a one-day focus group in September 2009. Their task was to provide comments on the strategies for risk communication that have emanated from the various interest groups within the different countries. Another reason for their engagement was to elicit their comments on the central features of existing materials and thus point to any strengths and weaknesses associated with various risk communication techniques and more composite risk communication strategies. The results obtained reflect the opinions and sentiments related to risks and safety of various groups in civil society within the participating countries. We also believe that the work performed in D18 fits well into the transparency framework provided in the RISCOM model. This model was successfully used in Sweden and has actually also been applied in the Czech Republic within the ARGONA project. It was shown that if applied in practice this model has a high potential for improving transparency related to consensus building in the NWM area

TH-AB-202-03: A Novel Tool for Computing Deliverable Doses in Dynamic MLC Tracking Treatments

Energy Technology Data Exchange (ETDEWEB)

Fast, M; Kamerling, C; Menten, M; Nill, S; Oelfke, U [The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London (United Kingdom); Crijns, S; Raaymakers, B [University Medical Center Utrecht, Utrecht (Netherlands)

2016-06-15

Purpose: In tracked dynamic multi-leaf collimator (MLC) treatments, segments are continuously adapted to the target centroid motion in beams-eye-view. On-the-fly segment adaptation, however, potentially induces dosimetric errors due to the finite MLC leaf width and non-rigid target motion. In this study, we outline a novel tool for computing the 4d dose of lung SBRT plans delivered with MLC tracking. Methods: The following automated workflow was developed: A) centroid tracking, where the initial segments are morphed to each 4dCT phase based on the beams-eye-view GTV shift (followed by a dose calculation on each phase); B) re-optimized tracking, in which all morphed initial plans from (A) are further optimised (“warm-started”) in each 4dCT phase using the initial optimisation parameters but phase-specific volume definitions. Finally, both dose sets are accumulated to the reference phase using deformable image registration. Initial plans were generated according to the RTOG-1021 guideline (54Gy, 3-Fx, equidistant 9-beam IMRT) on the peak-exhale (reference) phase of a phase-binned 4dCT. Treatment planning and delivery simulations were performed in RayStation (research v4.6) using our in-house segment-morphing algorithm, which directly links to RayStation through a native C++ interface. Results: Computing the tracking plans and 4d dose distributions via the in-house interface takes 5 and 8 minutes respectively for centroid and re-optimized tracking. For a sample lung SBRT patient with 14mm peak-to-peak motion in sup-inf direction, mainly perpendicular leaf motion (0-collimator) resulted in small dose changes for PTV-D95 (−13cGy) and GTV-D98 (+18cGy) for the centroid tracking case compared to the initial plan. Modest reductions of OAR doses (e.g. spinal cord D2: −11cGy) were achieved in the idealized tracking case. Conclusion: This study presents an automated “1-click” workflow for computing deliverable MLC tracking doses in RayStation. Adding a non-deliverable

TH-AB-202-03: A Novel Tool for Computing Deliverable Doses in Dynamic MLC Tracking Treatments

International Nuclear Information System (INIS)

Fast, M; Kamerling, C; Menten, M; Nill, S; Oelfke, U; Crijns, S; Raaymakers, B

2016-01-01

Purpose: In tracked dynamic multi-leaf collimator (MLC) treatments, segments are continuously adapted to the target centroid motion in beams-eye-view. On-the-fly segment adaptation, however, potentially induces dosimetric errors due to the finite MLC leaf width and non-rigid target motion. In this study, we outline a novel tool for computing the 4d dose of lung SBRT plans delivered with MLC tracking. Methods: The following automated workflow was developed: A) centroid tracking, where the initial segments are morphed to each 4dCT phase based on the beams-eye-view GTV shift (followed by a dose calculation on each phase); B) re-optimized tracking, in which all morphed initial plans from (A) are further optimised (“warm-started”) in each 4dCT phase using the initial optimisation parameters but phase-specific volume definitions. Finally, both dose sets are accumulated to the reference phase using deformable image registration. Initial plans were generated according to the RTOG-1021 guideline (54Gy, 3-Fx, equidistant 9-beam IMRT) on the peak-exhale (reference) phase of a phase-binned 4dCT. Treatment planning and delivery simulations were performed in RayStation (research v4.6) using our in-house segment-morphing algorithm, which directly links to RayStation through a native C++ interface. Results: Computing the tracking plans and 4d dose distributions via the in-house interface takes 5 and 8 minutes respectively for centroid and re-optimized tracking. For a sample lung SBRT patient with 14mm peak-to-peak motion in sup-inf direction, mainly perpendicular leaf motion (0-collimator) resulted in small dose changes for PTV-D95 (−13cGy) and GTV-D98 (+18cGy) for the centroid tracking case compared to the initial plan. Modest reductions of OAR doses (e.g. spinal cord D2: −11cGy) were achieved in the idealized tracking case. Conclusion: This study presents an automated “1-click” workflow for computing deliverable MLC tracking doses in RayStation. Adding a non-deliverable

CRISP. Dependable ICT Support of Power Grid Operations

Energy Technology Data Exchange (ETDEWEB)

Gustavsson, R.; Mellstrand, P.; Tornqvist, B. [Blekinge Institute of Technology BTH, Karlskrona (Sweden); Akkermans, H. [EnerSearch, Malmoe (Sweden)

2005-03-15

This deliverable D2.4 Dependable ICT support 0f Power Grid Operations is a link between deliverable D1.6 Information security models and their economics and planned activities in WP III, that is, Implementation, Experiments and Tests. Background CRISP material includes deliverables of D2.2 Design document and multi-agent simulation tool for distributed demand-supply matching and D2.3 Design document and simulation tool for diagnostics of high-DG power networks. Furthermore there are links between this document and the deliverable D1.7 Report on distributed network architectures and D1.8 Reports on case study simulations and results. In short, this document specifies and extends the general background on security models and dependability models of deliverable D1.6 with CRISP specific material of D2.2 and D2.4 towards the experiments and tests of WP III. The focus of this deliverable is on dependable ICT support of power grid operation. By recasting the three CRISP experiments into three Scenarios in Chapter 2 we claim that we have a good description of benefits and challenges related to future virtual utilities. Among the challenges are securing trustworthy operation from a technical operation side (avoid disturbances such as blackouts) as wee as from a user-centric business point of view (value added power related services). Our investigation on proper means to safeguard operations of future virtual utilities begins with an assessment of lessons learned from recent (2003) big blackouts worldwide in Chapter 3. We propose an accident diagnosis and repair model (STAMP in Section 3.2) suitable for the complex socio-technical system we envisage for future cell-based virtual utilities. From this analysis and the background material from deliverable D1.6 Information security models and their economics, we then reassess the dependability concerns related to the CRISP related scenarios of Chapter 2. The deliverable provides some novel ideas and models that we claim are

CRISP. Dependable ICT Support of Power Grid Operations

International Nuclear Information System (INIS)

Gustavsson, R.; Mellstrand, P.; Tornqvist, B.; Akkermans, H.

2005-03-01

This deliverable D2.4 Dependable ICT support 0f Power Grid Operations is a link between deliverable D1.6 Information security models and their economics and planned activities in WP III, that is, Implementation, Experiments and Tests. Background CRISP material includes deliverables of D2.2 Design document and multi-agent simulation tool for distributed demand-supply matching and D2.3 Design document and simulation tool for diagnostics of high-DG power networks. Furthermore there are links between this document and the deliverable D1.7 Report on distributed network architectures and D1.8 Reports on case study simulations and results. In short, this document specifies and extends the general background on security models and dependability models of deliverable D1.6 with CRISP specific material of D2.2 and D2.4 towards the experiments and tests of WP III. The focus of this deliverable is on dependable ICT support of power grid operation. By recasting the three CRISP experiments into three Scenarios in Chapter 2 we claim that we have a good description of benefits and challenges related to future virtual utilities. Among the challenges are securing trustworthy operation from a technical operation side (avoid disturbances such as blackouts) as wee as from a user-centric business point of view (value added power related services). Our investigation on proper means to safeguard operations of future virtual utilities begins with an assessment of lessons learned from recent (2003) big blackouts worldwide in Chapter 3. We propose an accident diagnosis and repair model (STAMP in Section 3.2) suitable for the complex socio-technical system we envisage for future cell-based virtual utilities. From this analysis and the background material from deliverable D1.6 Information security models and their economics, we then reassess the dependability concerns related to the CRISP related scenarios of Chapter 2. The deliverable provides some novel ideas and models that we claim are

Driver. D530.2 – Tools for the Lessons Learned Framework

NARCIS (Netherlands)

Schaik, M.G. van; et al

2016-01-01

In this deliverable D530.2 “Tools for the Lessons Learned Framework” the overall lessons learned framework will be clarified based on the delivery D53.1 “Lessons Learned Framework Concept” and aligned with the deliverable D52.1 “Harmonized competence framework”. The Tools for the Lessons Learned

Prospects and Challenges in the Deliverance of Executive Masters ...

African Journals Online (AJOL)

In the recent decade Executive Masters degree programmes have become very popular deliverance in the Tanzanian higher learning institutions. ... Using The Open University of Tanzania as a case study, this article will focus on two programmes, namely; Executive Masters in Business Administration (EMBA) and Masters ...

Multidimensional correlation among plan complexity, quality and deliverability parameters for volumetric-modulated arc therapy using canonical correlation analysis.

Science.gov (United States)

Shen, Lanxiao; Chen, Shan; Zhu, Xiaoyang; Han, Ce; Zheng, Xiaomin; Deng, Zhenxiang; Zhou, Yongqiang; Gong, Changfei; Xie, Congying; Jin, Xiance

2018-03-01

A multidimensional exploratory statistical method, canonical correlation analysis (CCA), was applied to evaluate the impact of complexity parameters on the plan quality and deliverability of volumetric-modulated arc therapy (VMAT) and to determine parameters in the generation of an ideal VMAT plan. Canonical correlations among complexity, quality and deliverability parameters of VMAT, as well as the contribution weights of different parameters were investigated with 71 two-arc VMAT nasopharyngeal cancer (NPC) patients, and further verified with 28 one-arc VMAT prostate cancer patients. The average MU and MU per control point (MU/CP) for two-arc VMAT plans were 702.6 ± 55.7 and 3.9 ± 0.3 versus 504.6 ± 99.2 and 5.6 ± 1.1 for one-arc VMAT plans, respectively. The individual volume-based 3D gamma passing rates of clinical target volume (γCTV) and planning target volume (γPTV) for NPC and prostate cancer patients were 85.7% ± 9.0% vs 92.6% ± 7.8%, and 88.0% ± 7.6% vs 91.2% ± 7.7%, respectively. Plan complexity parameters of NPC patients were correlated with plan quality (P = 0.047) and individual volume-based 3D gamma indices γ(IV) (P = 0.01), in which, MU/CP and segment area (SA) per control point (SA/CP) were weighted highly in correlation with γ(IV) , and SA/CP, percentage of CPs with SA plan quality with coefficients of 0.98, 0.68 and -0.99, respectively. Further verification with one-arc VMAT plans demonstrated similar results. In conclusion, MU, SA-related parameters and PTV volume were found to have strong effects on the plan quality and deliverability.

Identification of road user related risk factors, Deliverable 5.1 of the H2020 project SafetyCube (Safety CaUsation, Benefits and Efficiency).

NARCIS (Netherlands)

Filtness, A. & Papadimitriou, E. (Eds.) Leskovšek, B. Focant, N. Martensen, H. Sgarra, V. Usami, D.S. Soteropoulos, A. Stadlbauer, S. Theofilatos, A. Yannis, G. Ziakopoulos, A. Diamandouros, K. Durso, C. Goldenbeld, C. Loenis, B. Schermers, G. Petegem, J.-H. van Elvik, R. Hesjevoll, I.S. Quigley, C. & Papazikou, E.

2017-01-01

The present Deliverable (D5.1) describes the identification and evaluation of infrastructure related risk factors. It outlines the results of Task 5.1 of WP5 of SafetyCube, which aimed to identify and evaluate infrastructure related risk factors and related road safety problems by (i) presenting a

Towards transparent, proportionate and deliverable regulation for geological disposal

International Nuclear Information System (INIS)

2010-01-01

As part of its activities, the Regulators' Forum of the NEA Radioactive Waste Management Committee has been examining the regulatory criteria for the long-term performance of geological disposal. In this context, it organised a workshop entitled 'Towards Transparent, Proportionate and Deliverable Regulation for Geological Disposal', which served to verify current status and needs. Participants included regulators, implementers, policy makers, R and D specialists and academics. Themes addressed included duties to future generations, timescales for regulation, stepwise decision making, roles of optimisation and best available techniques (BAT), multiple lines of reasoning, safety and performance indicators, recognition of uncertainties and the importance of stakeholder interactions. The workshop highlighted the significant amount of work accomplished over the past decade, but also identified important differences between national regulations even if these are not in contradiction with international guidance. Also highlighted was the importance of R and D carried out on behalf of the regulator. In addition to the contributed papers, these proceedings trace the numerous discussions that formed an integral part of the workshop. They constitute an important and unique documentary basis for researchers and radioactive waste management specialists

Possibilities for a valorisation of geomorphologic research deliverables

Science.gov (United States)

Geilhausen, M.; Götz, J.; Otto, J.-C.; Schrott, L.

2009-04-01

Many geomorphological studies focus on fundamental research questions in large parts, although there are lots of applied fields like landslide hazard assessment or water framework directive. As fundamental research is a common property, their outcomes should be more "open" and accessible to the public. This means that scientists have to find new ways presenting their results and outcomes besides publishing in scientific journals. This paper shows possibilities for a valorisation of geomorphologic research deliverables using print as well as digital media. Geotrails explain remarkable and exciting landscape features using information boards and become more and more popular and important for tourism in many parts of the world. With the growing interest in environmental change and outdoor activities, print media like field guides reach an increasing number of people. Field guides and Geotrails can be coupled in order to arise awareness about geomorphological landforms and to deliver more specific information on the site beyond the information given on the boards in the field. As field guides are designed for the general public they can be used for educational purposes as well. Today, this information can also be found in the internet offering virtual trips through landscapes using dynamic maps. Here, server side GIS technologies (WebGIS) using standardised interfaces provide new possibilities to show geomorphic data to the public and to share them with the scientific community. Furthermore, data formats like XML or KML are powerful tools for data exchange and can be used in interactive data viewers like Google Earth. We will present the Geotrail "Geomorphologischer Lehrpfad am Fuße der Zugspitze. Das Reintal - Eine Wanderung durch Raum und Zeit" (Bavarian Alps, Germany). Additionally, three geomorphologic WebGIS applications (Geomorphologic map Turtmanntal, Permafrostmap of Austria, Geomorphologic maps of Germany) will exemplify how geomorphologic information and

ADAM adaptation and mitigation strategies: supporting European climate policy. Deliverable D3 of work package M1 (code D-M1.3). ADAM 2-degree scenario for Europe - policies and impacts

Energy Technology Data Exchange (ETDEWEB)

Schade, Wolfgang; Jochem, Eberhard; Barker, Terry [and others

2009-07-31

ADAM research identifies and appraises existing and new policy options that can contribute to different combinations of adaptation and mitigation strategies. These options address the demands a changing climate will place on protecting citizens and valuable ecosystems - i.e., adaptation - as well as addressing the necessity to restrain/control humankind's perturbation to global climate to a desirable level - i.e., mitigation. The work package Mitigation 1 (Ml) has the core objective to simulate mitigation options and their related costs for Europe until 2050 and 2100 respectively. The focus of this deliverable is on the period 2005 to 2050. The long-term period until 2100 is covered in the previous deliverable D2, applying the POLES model for this time horizon. The analysis constitutes basically a techno-economic analysis. Depending on the sector analyzed it is either directly combined with a policy analysis (e.g. in the transport sector, renewables sector) or the policy analysis is performed qualitatively as a subsequent and independent step after the techno-economic analysis is completed (e.g. in the residential and service sectors). The book includes the following chapters: scenarios and macroeconomic assumptions; methodological issues analyzing mitigation options; the integrated global energy model POLES and its projections for the reference and 2 deg C scenarios; forest and basic materials sector; residential sector in Europe; the service (tertiary) and the primary sectors in Europe; basic products and other manufacturing industry sectors; transport sectors in Europe; renewable sector in Europe; conversion sector in Europe; syntheses and sectoral analysis in Europe; macroeconomic impacts of climate policy in the EU; the effects of the financial crisis on baseline simulations with implications for climate policy modeling: an analysis using the global model E3MG 2008-2012; conclusions and policy recommendations.

ADAM adaptation and mitigation strategies: supporting European climate policy. Deliverable D3 of work package M1 (code D-M1.3). ADAM 2-degree scenario for Europe - policies and impacts

Energy Technology Data Exchange (ETDEWEB)

Schade, Wolfgang; Jochem, Eberhard; Barker, Terry (and others)

2009-07-31

ADAM research identifies and appraises existing and new policy options that can contribute to different combinations of adaptation and mitigation strategies. These options address the demands a changing climate will place on protecting citizens and valuable ecosystems - i.e., adaptation - as well as addressing the necessity to restrain/control humankind's perturbation to global climate to a desirable level - i.e., mitigation. The work package Mitigation 1 (Ml) has the core objective to simulate mitigation options and their related costs for Europe until 2050 and 2100 respectively. The focus of this deliverable is on the period 2005 to 2050. The long-term period until 2100 is covered in the previous deliverable D2, applying the POLES model for this time horizon. The analysis constitutes basically a techno-economic analysis. Depending on the sector analyzed it is either directly combined with a policy analysis (e.g. in the transport sector, renewables sector) or the policy analysis is performed qualitatively as a subsequent and independent step after the techno-economic analysis is completed (e.g. in the residential and service sectors). The book includes the following chapters: scenarios and macroeconomic assumptions; methodological issues analyzing mitigation options; the integrated global energy model POLES and its projections for the reference and 2 deg C scenarios; forest and basic materials sector; residential sector in Europe; the service (tertiary) and the primary sectors in Europe; basic products and other manufacturing industry sectors; transport sectors in Europe; renewable sector in Europe; conversion sector in Europe; syntheses and sectoral analysis in Europe; macroeconomic impacts of climate policy in the EU; the effects of the financial crisis on baseline simulations with implications for climate policy modeling: an analysis using the global model E3MG 2008-2012; conclusions and policy recommendations.

Multivariate time series analysis of SafetyNet data. SafetyNet, Building the European Road Safety Observatory, Workpackage 7, Deliverable 7.7.

NARCIS (Netherlands)

Commandeur, J.J.F. Bijleveld, F.D. & Bergel, R.

2009-01-01

This deliverable provides an application of theories and methods documented in Deliverables 7.4 and 7.5 of work package 7 of the SafetyNet project. In this deliverable, use of select analysis techniques is demonstrated through real world road safety analysis problems, using aggregate data which may

LANL12-RS-107J PYTHON Radiography Analysis Tool (PyRAT). Mid-Year Deliverable Report for FY15

International Nuclear Information System (INIS)

Temple, Brian Allen; Armstrong, Jerawan Chudoung

2015-01-01

This document is a mid-year report on a deliverable for the PYTHON Radiography Analysis Tool (PyRAT) for project LANL12-RS-107J in FY15. The deliverable is deliverable number 2 in the work package and is titled ''Add the ability to read in more types of image file formats in PyRAT''. Right now PyRAT can only read in uncompressed TIF files (tiff files). It is planned to expand the file formats that can be read by PyRAT, making it easier to use in more situations. A summary of the file formats added include jpeg, jpg, png and formatted ASCII files.

Cassandra - D7.3.4 - M24 status report dissemination results

NARCIS (Netherlands)

Klievink, A.J.

2013-01-01

This deliverable is a status report on the dissemination activities and results in the CASSANDRA project. These status reports are made regularly, with two more to come. Together, these make up deliverable D7.3 – Dissemination results. In this fifth report, the results of the dissemination

Dosimetric quality, accuracy, and deliverability of modulated radiotherapy treatments for spinal metastases

Energy Technology Data Exchange (ETDEWEB)

Kairn, Tanya, E-mail: t.kairn@gmail.com [Genesis Cancer Care Queensland, Auchenflower (Australia); School of Chemistry, Physics, and Mechanical Engineering, Queensland University of Technology, Brisbane (Australia); Papworth, Daniel [Genesis Cancer Care Queensland, Auchenflower (Australia); Crowe, Scott B. [School of Chemistry, Physics, and Mechanical Engineering, Queensland University of Technology, Brisbane (Australia); Cancer Care Services, Royal Brisbane and Women' s Hospital, Herston (Australia); Anderson, Jennifer [Genesis Cancer Care Queensland, Auchenflower (Australia); Christie, David R.H. [Genesis Cancer Care Queensland, Auchenflower (Australia); School of Medicine, Bond University, Robina (Australia)

2016-10-01

Cancer often metastasizes to the vertebra, and such metastases can be treated successfully using simple, static posterior or opposed-pair radiation fields. However, in some cases, including when re-irradiation is required, spinal cord avoidance becomes necessary and more complex treatment plans must be used. This study evaluated 16 sample intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) treatment plans designed to treat 6 typical vertebral and paraspinal volumes using a standard prescription, with the aim of investigating the advantages and limitations of these treatment techniques and providing recommendations for their optimal use in vertebral treatments. Treatment plan quality and beam complexity metrics were evaluated using the Treatment And Dose Assessor (TADA) code. A portal-imaging–based quality assurance (QA) system was used to evaluate treatment delivery accuracy, and radiochromic film measurements were used to provide high-resolution verification of treatment plan dose accuracy, especially in the steep dose gradient regions between each vertebral target and spinal cord. All treatment modalities delivered approximately the same doses and the same levels of dose heterogeneity to each planning target volume (PTV), although the minimum PTV doses in the vertebral plans were substantially lower than the prescription, because of the requirement that the plans meet a strict constraint on the dose to the spinal cord and cord planning risk volume (PRV). All plans met required dose constraints on all organs at risk, and all measured PTV-cord dose gradients were steeper than planned. Beam complexity analysis suggested that the IMRT treatment plans were more deliverable (less complex, leading to greater QA success) than the VMAT treatment plans, although the IMRT plans also took more time to deliver. The accuracy and deliverability of VMAT treatment plans were found to be substantially increased by limiting the number of

20 CFR 638.300 - Eligibility for funds and eligible deliverers.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Eligibility for funds and eligible deliverers. 638.300 Section 638.300 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR JOB CORPS PROGRAM UNDER TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Funding, Site Selection...

Cassandra - D7.3.5 - M30 status : Report dissemination results

NARCIS (Netherlands)

Klievink, A.J.

2014-01-01

This deliverable is a status report on the dissemination activities and results in the CASSANDRA project. These status reports are made regularly, with one more to come at the project’s finish. Together, these make up deliverable D7.3 – Dissemination results. In this report, the results of the

D5.3 Interaction between currents, wave, structure and subsoil

DEFF Research Database (Denmark)

Christensen, Erik Damgaard; Sumer, B. Mutlu; Schouten, Jan-Joost

2015-01-01

This chapter gives an introduction to deliverable D5.3 - Interaction between currents, waves, structure and subsoil – with respect to the MERMAID project. The deliverable focuses on the conditions in European waters such as the four sites that is addressed in the MERMAID project. The most important...

SU-F-T-333: Deliverability Considerations in Modulated Photon Radiotherapy (XMRT)

Energy Technology Data Exchange (ETDEWEB)

McGeachy, P [Department of Medical Physics, CancerCare Manitoba, Winnipeg, MB (Canada); Weppler, S; Villarreal-Barajas, J [Department of Physics and Astronomy, University of Calgary, Calgary, Alberta (Canada); Department of Medical Physics, Tom Baker Cancer Center, Calgary, AB (Canada); Zinchenko, Y [Department of Mathematics and Statistics, University of Calgary, Calgary, Alberta (Canada); Khan, R [Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO (United States)

2016-06-15

Purpose: Modulated Photon Radiotherapy (XMRT), which simultaneously optimizes photon beamlet energy (6 and 18 MV) and fluence, has shown dosimetric improvements for fluence map optimization (FMO) when compared to conventional single-energy intensity modulated radiotherapy. However, generating deliverable multi-leaf collimator (MLC) sequences for XMRT needs to be explored. Therefore, two problems were investigated: 1) The ability to generate MLC-sequenced fluence maps from FMO XMRT solutions for a prostate case 2) The impact of fluence smoothening constraints imposed in the FMO on the deliverability and dose distribution. Methods: XMRT FMO solutions for a clinical prostate case employing standard dosimetric constraints, prescriptions, and a seven coplanar beam arrangement were generated. Smoothening constraints in the FMO utilized a sum of positive gradients approach. Sequenced maps were generated using an in-house optimization algorithm (MLCSO). The maximum leaf speed, minimum leaf separation, and transmission through MLC leaves were set to 2.5 mm/s, 1 mm, and 1%, respectively. The resulting sequenced maps for each field were compared with the original FMO solutions through gamma analysis (0.5%/0.5 mm) and root mean square error (RMSE). This comparison was done for both the smoothed and unsmoothed XMRT solutions. Results: Average RMSE and gamma agreement of 0.44, 93%and 0.36, 95% were obtained for unsmoothed 6 and 18 MV contributions from XMRT sequenced maps. The sequenced maps with smoothening constraints had better agreement with their respective optimal fluences, with RMSEs of 0 and gamma pass rates of 100% for all comparisons. This improved smoothening led to increased dose to critical structures (rectum, bladder, and femoral heads); however solutions were still clinically acceptable. Conclusion: For a clinical prostate case, XMRT FMO fluence maps were suitable for conversion into deliverable MLC sequences. Imposing smoothening constraints during FMO resulted

D4SCIENCE-II - Report on inter-projects coordination and collaboration

OpenAIRE

Castelli, Donatella; Zoppi, Franco

2010-01-01

This deliverable reports on the collaborations with other FP7 projects and R&D programmes established by D4Science-II from the beginning of the project until July 2010. The collaborations described are of different nature, as they range from purely technical exchanges involving mutual exploitation of technologies to the sharing of e- Infrastructure resources and to the joint organization of networking and dissemination events. The deliverable presents these collaborations clustered into: (i) ...

Road Safety Data, Collection, Transfer and Analysis DaCoTa. Deliverable 1.2: Road safety management investigation model and questionnaire.

NARCIS (Netherlands)

Dupont, H. Martensen, H. Papadimitriou, E. Yannis, G. Muhlrad, N. Jähi, H. Vallet, G. Giustiniani, G. Tripodi, A. Usami, D. Bax, C. Wijnen, W. Schöne, M.-L. Machata, K. Buttler, I. Zysinska, M. Talbot, R. Gitelman, V. & Hakkert, S. & Muhlrad, N. Gitelman, V. & Buttler, I. (Eds.)

2012-01-01

The aim of the DaCoTA Work Package 1 is to investigate road safety policy-making and management processes in Europe. In the Deliverables released previously, the Work Package 1 assessed the experts’ needs in terms of road safety knowledge, data and decision support tools (Deliverable 1.1/4.1), as

Short-term Canadian natural gas deliverability 2008-2010 : an energy market assessment

International Nuclear Information System (INIS)

2008-10-01

This document examined the factors that affect gas supply in the short term and presented an outlook for deliverability through 2010. Its primary purpose was to advance public understanding of the short-term gas supply situation in Canada. For the past several years, Canadian natural gas has provided about 25 per cent of combined Canadian and U.S. production. Canadian gas deliverability remained within a narrow range from 2000 to mid-2007 at around 483 million cubic metres and has since begun to decline. About 98 per cent of the Canadian volume comes from the Western Canada Sedimentary Basin (WCSB), with most of the rest coming from Atlantic Canada. Although drilling and development activity in the WCSB has depended on the price of natural gas relative to costs, that price was influenced by uncertainties such as weather-driven market demand, changes in natural gas supply, cost, attractiveness of other basins, availability of imported liquefied natural gas and possible supply disruptions in the Gulf of Mexico. Shale gas and tight gas prospects in the Horn River and Montney plays of northeast British Columbia have attracted considerable interest from Canada's upstream industry. Early stages of shale gas development are also underway in Quebec and the Maritimes. However, the viability of large scale commercial development of shale gas in Canada has yet to be proven. In order to reflect the short-term uncertainty of the North American natural gas market, this report project deliverability under 3 cases that reflect different levels of drilling investment, namely reference case, high case and low case scenarios. 4 tabs., 12 figs

Short-term Canadian natural gas deliverability 2008-2010 : an energy market assessment

Energy Technology Data Exchange (ETDEWEB)

NONE

2008-10-15

This document examined the factors that affect gas supply in the short term and presented an outlook for deliverability through 2010. Its primary purpose was to advance public understanding of the short-term gas supply situation in Canada. For the past several years, Canadian natural gas has provided about 25 per cent of combined Canadian and U.S. production. Canadian gas deliverability remained within a narrow range from 2000 to mid-2007 at around 483 million cubic metres and has since begun to decline. About 98 per cent of the Canadian volume comes from the Western Canada Sedimentary Basin (WCSB), with most of the rest coming from Atlantic Canada. Although drilling and development activity in the WCSB has depended on the price of natural gas relative to costs, that price was influenced by uncertainties such as weather-driven market demand, changes in natural gas supply, cost, attractiveness of other basins, availability of imported liquefied natural gas and possible supply disruptions in the Gulf of Mexico. Shale gas and tight gas prospects in the Horn River and Montney plays of northeast British Columbia have attracted considerable interest from Canada's upstream industry. Early stages of shale gas development are also underway in Quebec and the Maritimes. However, the viability of large scale commercial development of shale gas in Canada has yet to be proven. In order to reflect the short-term uncertainty of the North American natural gas market, this report project deliverability under 3 cases that reflect different levels of drilling investment, namely reference case, high case and low case scenarios. 4 tabs., 12 figs.

Natural gas market assessment. Natural gas supply, western Canada: Recent developments (1982-1992), [and] short-term deliverability outlook (1993-1996)

International Nuclear Information System (INIS)

1993-11-01

A review is presented of the evolution of gas supply from western Canada over the last ten years and a short-term forecast of gas deliverability. To illustrate the changed supply conditions, selected trends and market developments are summarized, including trends in excess deliverability, changes in reserves, the regional distribution of cumulative production, the pace of tieing-in of previously discovered pools for production, the expansion in deliverability from gas storage reservoirs, and recent increases in drilling activity. On the basis of analyses and observations, it is concluded that estimated productive capacity is likely to exceed pipeline capacity on a peak-day basis by a narrow margin over 1993-96. Increasing deliverability from gas storage reservoirs located in the producing provinces is an important factor in handling peak day requirements. From time to time, high demand due to extreme weather conditions could result in pronounced tightness and price fluctuations similar to those seen in winter 1992/93. A strong economic recovery could also result in market tightness, depending on the speed and size of supply response. The growing estimates of resource potential in the western Canada sedimentary basin provide an encouraging indication of the availability of future supply. 29 figs., 3 tabs

An Assessment Tool to Detect Unique Characteristics of Cognitive Deficiency

Science.gov (United States)

2017-06-01

http://mhealth.amegroups.com/article/view/11037 4. Steeg Morris , D., Lathan, C., Weissfeld, L, Lacy, T., & Resnick, H. R. (2016, August). Trial...platform for assessing brain health. MHealth, 2(7). Retrieved from http://mhealth.amegroups.com/article/view/11037 4. Steeg Morris , D., Lathan, C...0141) DELIVERABLES All deliverables will be submitted on Tuesday May 16, 2017 via FedEx on a CD, tracking number is 7791 5006 0944. The items

D1.1 Detailed requirements for GloNet use case and domain glossary

NARCIS (Netherlands)

Afsarmanesh, H.; Korojelo, S.; Sargolzaei, M.; Thamburaj, V.; Madhavan, V.; Camarinha-Matos, L.

2012-01-01

D1.1 is one of the first deliverables of the project, which sets the base for research in all other WPs in GloNet. The findings reported in this deliverable are resulted through direct involvement of the two energy related industries within the GloNet consortium (iPLON and Prolon), as well as the

Deliverability on the interstate natural gas pipeline system

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-05-01

Deliverability on the Interstate Natural Gas Pipeline System examines the capability of the national pipeline grid to transport natural gas to various US markets. The report quantifies the capacity levels and utilization rates of major interstate pipeline companies in 1996 and the changes since 1990, as well as changes in markets and end-use consumption patterns. It also discusses the effects of proposed capacity expansions on capacity levels. The report consists of five chapters, several appendices, and a glossary. Chapter 1 discusses some of the operational and regulatory features of the US interstate pipeline system and how they affect overall system design, system utilization, and capacity expansions. Chapter 2 looks at how the exploration, development, and production of natural gas within North America is linked to the national pipeline grid. Chapter 3 examines the capability of the interstate natural gas pipeline network to link production areas to market areas, on the basis of capacity and usage levels along 10 corridors. The chapter also examines capacity expansions that have occurred since 1990 along each corridor and the potential impact of proposed new capacity. Chapter 4 discusses the last step in the transportation chain, that is, deliverability to the ultimate end user. Flow patterns into and out of each market region are discussed, as well as the movement of natural gas between States in each region. Chapter 5 examines how shippers reserve interstate pipeline capacity in the current transportation marketplace and how pipeline companies are handling the secondary market for short-term unused capacity. Four appendices provide supporting data and additional detail on the methodology used to estimate capacity. 32 figs., 15 tabs.

Bioclim Deliverable D6a: regional climatic characteristics for the European sites at specific times: the dynamical down-scaling

International Nuclear Information System (INIS)

2003-01-01

many millennia. These results are then interpreted in terms of regional climatic changes using rule-based and statistical down-scaling approaches. This deliverable, D6a, focuses on the hierarchical strategy, and in particular the MAR simulations. According to the hierarchical strategy developed in the BIOCLIM project to predict future climate, six BIOCLIM experiments were run with the MAR model. In addition to these experiments a baseline experiment, presenting the present-day climate simulated by MAR, was also undertaken. In the first step of the hierarchical strategy the LLN 2-D NH climate model simulated the gross features of the climate of the next 1 Myr. Six snapshot experiments were selected from these results. In a second step a GCM and a biosphere model were used to simulate in more detail the climate of the selected time periods. These simulations were performed on a global scale. The third step of the procedure is to derive the regional features of the climate at the same time periods. Therefore the results of the GCM are used as boundary conditions to force the regional climate model (MAR) for the six selected periods and the baseline simulation. The control simulation (baseline) corresponds to the regional climate simulated under present-day conditions, both insolation forcing and atmospheric CO 2 concentration. All the BIOCLIM simulations are compared to that baseline simulation. In addition, other comparisons will also be presented

Deconstructing national leadership: politicians' accounts of electoral success and failure in the Irish Lisbon Treaty referenda.

Science.gov (United States)

Burns, Michele; Stevenson, Clifford

2013-03-01

The Self Categorization approach to national leadership proposes that leaders rhetorically construct national identity as essentialized and inevitable in order to consensualize and mobilize the population. In contrast, discursive studies have demonstrated how national politicians flexibly construct the nation to manage their own accountability in local interactions, though this in turn has neglected broader leadership processes. The present paper brings both approaches together to examine how and when national politicians construct versions of national identity in order to account for their failure as well as success in mobilizing the electorate. Eight semi-structured conversational style interviews were conducted with a strategic sample of eight leading Irish politicians on the subject of the 2008/2009 Irish Lisbon Treaty referenda. Using a Critical Discourse Psychology approach, the hegemonic repertoire of the 'settled will' of the informed and consensualized Irish nation was identified across all interviews. Politicians either endorsed the 'settled will' repertoire as evidence of their successful leadership, or rejected the repertoire by denying the rationality or unity of the populace to account for their failure. Our results suggest national identity is only constructed as essentialized and inevitable to the extent that it serves a strategic political purpose. © 2011 The British Psychological Society.

16-level differential phase shift keying (D16PSK) in direct detection optical communication systems

DEFF Research Database (Denmark)

Sambaraju, R.; Tokle, Torger; Jensen, J.B.

2006-01-01

Optical 16-level differential phase shift keying (D16PSK) carrying four bits for every symbol is proposed for direct detection optical communication systems. Transmitter and receiver schematics are presented, and the receiver sensitivity is discussed. We numerically investigate the impact...

Short-term Canadian natural gas deliverability 2006-2008 : an energy market assessment

International Nuclear Information System (INIS)

2006-10-01

This report presented an assessment of the expected capability of Canadian gas production through to the year 2008. Strong natural gas prices have led to record drilling levels in Canada's natural gas industry. North American natural gas prices reached a peak near the end of 2005. The rise in prices during 2005 reflected high world crude oil prices, a tight balance between natural gas supply and demand, and disruptions to United States gas supply from 2 hurricanes. In response to rising prices, western Canada drilling activity achieved new highs in early 2006. Higher drilling rates also reflected rising costs for key inputs of steel, fuel, and labour. Gas prices have since softened due to a storage overhang resulting from a mild winter. The combination of rising costs and softening prices has impacted margins for Canadian gas producers. In response, some producers have reduced drilling expansion plans in coalbed methane (CBM) and shallow gas plays in the Western Canadian Sedimentary Basin (WCSB). Increases in deeper gas drilling have been maintained. Total gas drilling for 2006 is expected to rise by 3 per cent compared to 2005. The report projected a small increase in Canada's total annual gas production from 484 million m 3 /d in 2005 to 491 million m 3 /d in 2008. Annual average deliverability of conventional gas is expected to decline slightly over the projection period. The decrease is expected to be more than offset by growth in CBM production in western Canada, which is expected to increase from 8 million m 3 /d in 2005 to 27 million m 3 /d in 2008. 5 tabs., 5 figs

Outlook for B.C. gas production and deliverability in relation to domestic and export markets

International Nuclear Information System (INIS)

Phelps, M.E.J.

1993-01-01

The business outlook for natural gas in British Columbia is discussed. Drilling activity in B.C. is increasing, and it is predicted that reserve additions over 1993-1998 will total 3.4 terra cubic feet. Deliverability in 1993 is 1.9 billion cubic feet/d, and this is expected to rise 30% by 1998. Westcoast is doubling raw gas capacity at the Pine River plant and is constructing new raw gas transmission lines. Growth is expected to continue at 6%/y for the next five years. In the deregulated environment, short term fluctuations in price are to be expected, however consumers are reluctant to tolerate price increases when levels of disposable income are static or decreasing. Regular, predictable and sustained increases in prices are preferable to sudden, significant oscillations, especially for residental customers

Detectors in 3D available for assessment

CERN Document Server

Re, Valerio

2014-01-01

This deliverable reports on 3D devices resulting from the vertical integration of pixel sensors and readout electronics. After 3D integration steps such as etching of through-silicon vias and backside metallization of readout integrated circuits, ASICs and sensors are interconnected to form a 3D pixel detector. Various 3D detectors have been devised in AIDA WP3 and their status and performance is assessed here.

Contribution to the study of (d,p) and (d,{alpha}> reactions on {sup 16}O and {sup 11}B from 200 keV to 1 MeV; Contribution a l'etude des reactions (d,p) et (d,{alpha}) sur {sup 16}O et {sup 11}B de 200 keV a 1 MeV

Energy Technology Data Exchange (ETDEWEB)

Longequeue, N [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1965-05-01

The reactions {sup 16}O(d,{alpha}{sub 0}), (d,p{sub 0}), (d,p{sub 1}) and {sup 11}B(d,{alpha}{sub 0}), (d,{alpha}{sub 2}), (d,p{sub 0}) have been studied from 200 keV to 1 MeV. The interpretation of (d,{alpha}) reactions by the compound nucleus theory has shown the presence of {sup 18}F levels (7,94 MeV, 1+; 8,09 MeV, 1+ ) and of {sup 13}C level (19 MeV, 3/2{+-} or 5/2-). The interpretation of {sup 16}O(d,p{sub 1}) and {sup 11}B(d,p{sub 0}) reactions at energies lower than 400 keV has been given by a theory of Coulomb stripping. (author) [French] L'etude experimentale des reactions {sup 16}O(d,{alpha}{sub 0}); (d,p{sub 0}), (d,p{sub 1}) et {sup 11}B(d,{alpha}{sub 0}), (d,{alpha}{sub 2}), (d,p{sub 0}) a ete faite de 200 keV a 1 Mev. L'interpretation des reactions (d,a) par la theorie du noyau compose a permis la mise en evidence de niveaux du {sup 18}F (7,94 MeV, 1+; 8,09MeV, 1+ ) et du {sup 13}C(19 MeV, 3/2{+-} ou 5/2-). L'interpretation des reactions {sup 16}O(d,p{sub 1}) et {sup 11}B(d,p{sub 0}), a basse energie (< 400 keV), par une theorie de stripping de Coulomb, a ete donnee.

Final Report: Improved Site Characterization And Storage Prediction Through Stochastic Inversion Of Time-Lapse Geophysical And Geochemical Data

Energy Technology Data Exchange (ETDEWEB)

Ramirez, A; Mcnab, W; Hao, Y; White, D; Johnson, J

2011-04-14

During the last months of this project, our project activities have concentrated on four areas: (1) performing a stochastic inversion of pattern 16 seismic data to deduce reservoir bulk/shear moduli and density; the need for this inversion was not anticipated in the original scope of work, (2) performing a stochastic inversion of pattern 16 seismic data to deduce reservoir porosity and permeability, (3) complete the software needed to perform geochemical inversions and (4) use the software to perform stochastic inversion of aqueous chemistry data to deduce mineral volume fractions. This report builds on work described in progress reports previously submitted (Ramirez et al., 2009, 2010, 2011 - reports fulfilled the requirements of deliverables D1-D4) and fulfills deliverable D5: Field-based single-pattern simulations work product. The main challenge with our stochastic inversion approach is its large computational expense, even for single reservoir patterns. We dedicated a significant level of effort to improve computational efficiency but inversions involving multiple patterns were still intractable by project's end. As a result, we were unable to fulfill Deliverable D6: Field-based multi-pattern simulations work product.

Bioclim Deliverable D3: global climatic features over the next million years and recommendation for specific situations to be considered

International Nuclear Information System (INIS)

2001-01-01

The BIOCLIM project aims at assessing the possible long-term impacts of climate change on the safety of waste repositories in deep formations using climate simulations of the long-term climate in various European areas. One of the objectives of the project is to develop two strategies for representing sequential climatic changes to the geosphere-biosphere system for different sites over Europe, addressing the time scale of one million years. The results of this work will be interpreted in terms of global or regional changes of climate and of vegetation. The first strategy (hierarchical strategy) will use the full hierarchy of existing climate models (a climate model is a numerical simplified representation of the climate system behaviour and evolution). Simple models (LLN 2-D NH and threshold models; see the description here after) will simulate the overall long-term evolution of the global climate. Their results will then be used as inputs to more complex models (LMD climate models possibly coupled with vegetation models, either SECHIBA or ORCHIDE) and finally climate and vegetation cover will be determined for specific sites at specific times. A second strategy (integrated strategy) will consist in building an integrated climate model, which represents most of the physical mechanisms for studying long-term climatic variations. The results will then be interpreted on a regional scale. This deliverable is the first step of the hierarchical strategy. The purpose of this deliverable is to identify and justify some specific climatic situations amongst different long-term simulations that are of interest for assessing the safety of radioactive waste repository sites and that will be further studied with GCMs (General Circulation Model). The simple threshold (or multi-state) climate model is a modified version of the model from Paillard. It describes the time evolution of the ice volume and the CO 2 concentration. It has two distinct regimes (interglacial and glacial

Data needs and computational requirements for ST decision making. Internal deliverable ID6.2.1

DEFF Research Database (Denmark)

Clement, Rémy; Tournebise, Pascal; Perkin, Samuel

The objective of this deliverable is to present the requirements for adapting available tools/models and identifying data needs for probabilistic reliability analysis and optimal decision-making in the short-term decision making process. It will serve as a basis for the next tasks of GARPUR work ...

Record of principal work activities/deliverables

International Nuclear Information System (INIS)

1989-09-01

Over the five year period of performance, thirteen task assignments were issued by the DOE to ARINC Research. During the two year base period seven tasks were assigned. Two task assignments were issued for each of the three consecutive one year option periods. Associated with all task assignments were multiple subtasks, some of which required significant effort. These subtasks are appropriately cited in this report under their respective task assignments as principal work activities or deliverables. The technical and management support provided to the DOE under this contract focused on two general areas: (1) appraisal activities and (2) non-appraisal activities. Support to appraisals included planning, document review, developing lines-of-inquiry, interviewing, data collection, report writing, and follow-up. Such work was executed both on-site at the DOE facility under review and off-site. Non-appraisal support was varied and included such areas as document review, data base development, technical assessments. statistical analysis, policy analysis, reliability engineering, and workshop and conference planning and execution

SU-G-BRC-02: A Novel Multi-Criteria Optimization Approach to Generate Deliverable Intensity-Modulated Radiation Therapy (IMRT) Treatment Plans

Energy Technology Data Exchange (ETDEWEB)

Kirlik, G; D’Souza, W; Zhang, H [University of Maryland School of Medicine, Baltimore, MD (United States)

2016-06-15

Purpose: To present a novel multi-criteria optimization (MCO) solution approach that generates treatment plans with deliverable apertures using column generation. Methods: We demonstrate our method with 10 locally advanced head-and-neck cancer cases retrospectively. In our MCO formulation, we defined an objective function for each structure in the treatment volume. This resulted in 9 objective functions, including 3 distinct objectives for primary target volume, high-risk and low-risk target volumes, 5 objectives for each of the organs-at-risk (OARs) (two parotid glands, spinal cord, brain stem and oral cavity), and one for the non-target non-OAR normal tissue. Conditional value-at-risk (CVaR) constraints were utilized to ensure at least certain fraction of the target volumes receiving the prescription doses. To directly generate deliverable plans, column generation algorithm was embedded within our MCO approach for aperture shape generation. Final dose distributions for all plans were generated using a Monte Carlo kernel-superposition dose calculation. We compared the MCO plans with the clinical plans, which were created by clinicians. Results: At least 95% target coverage was achieved by both MCO plans and clinical plans. However, the average conformity indices of clinical plans and the MCO plans were 1.95 and 1.35, respectively (31% reduction, p<0.01). Compared to the conventional clinical plan, the proposed MCO method achieved average reductions in left parotid mean dose of 5% (p=0.06), right parotid mean dose of 18% (p<0.01), oral cavity mean dose of 21% (p=0.03), spinal cord maximum dose of 20% (p<0.01), brain stem maximum dose of 61% (p<0.01), and normal tissue maximum dose of 5% (p<0.01), respectively. Conclusion: We demonstrated that the proposed MCO method was able to obtain deliverable IMRT treatment plans while achieving significant improvements in dosimetric plan quality.

SU-F-P-64: The Impact of Plan Complexity Parameters On the Plan Quality and Deliverability of Volumetric Modulated Arc Therapy with Canonical Correlation Analysis

Energy Technology Data Exchange (ETDEWEB)

Jin, X; Yi, J; Xie, C [The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang (China)

2016-06-15

Purpose: To evaluate the impact of complexity indices on the plan quality and deliverability of volumetric modulated arc therapy (VMAT), and to determine the most significant parameters in the generation of an ideal VMAT plan. Methods: A multi-dimensional exploratory statistical method, canonical correlation analysis (CCA) was adopted to study the correlations between VMAT parameters of complexity, quality and deliverability, as well as their contribution weights with 32 two-arc VMAT nasopharyngeal cancer (NPC) patients and 31 one-arc VMAT prostate cancer patients. Results: The MU per arc (MU/Arc) and MU per control point (MU/CP) of NPC were 337.8±25.2 and 3.7±0.3, respectively, which were significantly lower than those of prostate cancer patients (MU/Arc : 506.9±95.4, MU/CP : 5.6±1.1). The plan complexity indices indicated that two-arc VMAT plans were more complex than one-arc VMAT plans. Plan quality comparison confirmed that one-arc VMAT plans had a high quality than two-arc VMAT plans. CCA results implied that plan complexity parameters were highly correlated with plan quality with the first two canonical correlations of 0.96, 0.88 (both p<0.001) and significantly correlated with deliverability with the first canonical correlation of 0.79 (p<0.001), plan quality and deliverability was also correlated with the first canonical correlation of 0.71 (p=0.02). Complexity parameters of MU/CP, segment area (SA) per CP, percent of MU/CP less 3 and planning target volume (PTV) were weighted heavily in correlation with plan quality and deliveability . Similar results obtained from individual NPC and prostate CCA analysis. Conclusion: Relationship between complexity, quality, and deliverability parameters were investigated with CCA. MU, SA related parameters and PTV volume were found to have strong effect on the plan quality and deliverability. The presented correlation among different quantified parameters could be used to improve the plan quality and the efficiency

Discrepancies between selected Pareto optimal plans and final deliverable plans in radiotherapy multi-criteria optimization.

Science.gov (United States)

Kyroudi, Archonteia; Petersson, Kristoffer; Ghandour, Sarah; Pachoud, Marc; Matzinger, Oscar; Ozsahin, Mahmut; Bourhis, Jean; Bochud, François; Moeckli, Raphaël

2016-08-01

Multi-criteria optimization provides decision makers with a range of clinical choices through Pareto plans that can be explored during real time navigation and then converted into deliverable plans. Our study shows that dosimetric differences can arise between the two steps, which could compromise the clinical choices made during navigation. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Performance studies of varian VPM-154D.6D VPM-154A/1.6L static crossed field photomultipliers

International Nuclear Information System (INIS)

Lo, C.C.; Leskovar, B.

1977-01-01

Characteristics have been measured for the Varian VPM-154D.6D and VPM-154A/1.6L Static Crossed Field Photomultipliers. Some typical photomultiplier characteristics such as: gain, dark current, quantum efficiency, and rise-time--are compared with data provided by the manufacturer. Photomultiplier characteristics generally not available from the manufacturer, such as: transit time, FWHM of the output pulse, peak output current measurement and multiphotoelectron time resolution were measured and are discussed

F-16D Pacer Calibration Techniques (SPEED PACER)

Science.gov (United States)

2012-07-01

from the calibration FTTs and therefore, would add flight hours to accomplish. Other variables used in creation of the total costs are as follows: F-16... ZULU Time --- ∆ static source error correction n/d Δ Psic static pressure instrument error correction inHg Δ Ptic total pressure

Decreased D2-40 and increased p16INK4A immunoreactivities correlate with higher grade of cervical intraepithelial neoplasia

Directory of Open Access Journals (Sweden)

Lu Zhouping

2011-07-01

Full Text Available Abstract Background D2-40 has been shown a selective marker for lymphatic endothelium, but also shown in the benign cervical basal cells. However, the application of D2-40 immunoreactivity in the cervical basal cells for identifying the grade of cervical intraepithelial neoplasia (CIN has not been evaluated. Methods In this study, the immunoreactive patterns of D2-40, compared with p16INK4A, which is currently considered as the useful marker for cervical cancers and their precancerous diseases, were examined in total 125 cervical specimens including 32 of CIN1, 37 of CIN2, 35 of CIN3, and 21 of normal cervical tissue. D2-40 and p16INK4A immunoreactivities were scored semiquantitatively according to the intensity and/or extent of the staining. Results Diffuse D2-40 expression with moderate-to-strong intensity was seen in all the normal cervical epithelia (21/21, 100% and similar pattern of D2-40 immunoreactivity with weak-to-strong intensity was observed in CIN1 (31/32, 97.2%. However, negative and/or focal D2-40 expression was found in CIN2 (negative: 20/37, 54.1%; focal: 16/37, 43.2% and CIN3 (negative: 22/35, 62.8%; focal: 12/35, 34.3%. On the other hand, diffuse immunostaining for p16INK4A was shown in 37.5% of CIN1, 64.9% of CIN2, and 80.0% of CIN3. However, the immunoreactive pattern of D2-40 was not associated with the p16INK4A immunoreactivity. Conclusions Immunohistochemical analysis of D2-40 combined with p16INK4A may have a significant implication in clinical practice for better identifying the grade of cervical intraepithelial neoplasia, especially for distinguishing CIN1 from CIN2/3.

16 CFR Appendix D2 to Part 305 - Water Heaters-Electric

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Water Heaters-Electric D2 Appendix D2 to... PRODUCTS REQUIRED UNDER THE ENERGY POLICY AND CONSERVATION ACT (âAPPLIANCE LABELING RULEâ) Pt. 305, App. D2 Appendix D2 to Part 305—Water Heaters—Electric Range Information CAPACITY FIRST HOUR RATING Range of...

Configurable 3D rotational X-ray reconstruction

NARCIS (Netherlands)

Nguyen, Xuan Huy

2012-01-01

This report is one of the deliverables of the project "Configurable 3D Rotational X-ray Reconstruction", carried out by the author as the final part of the Professional Doctorate in Engineering (PDEng) degree program in Software Technology provided by Eindhoven University of Technology and Stan

The dynamics of the reaction of 16O(1D)+D218O→16OD+18OD

International Nuclear Information System (INIS)

Guillory, W.A.; Gericke, K.H.; Comes, F.J.

1983-01-01

The detailed energy partitioning in the reaction of a metastable oxygen atom O( 1 D) with D 2 O proceeding to two OD molecules has been studied. In order to distinguish the product state distribution between the two chemically identical product molecules OD, the oxygen atom in the heavy water molecule was labeled isotopically. The use of spectroscopic methods allows a complete analysis of the products' state distribution including such fine details as the distribution of the different #betta# components and of the electron spin. The vibrational energy is almost exclusively channeled into the new ( 16 OD) bond, whereas the original ( 18 OD) bond is produced (>90%) in the ground vibrational state. Both OD radicals show a broad rotational excitation and the rotational energy is equally partitioned among the two bonds. The energy distribution over the rovibrational levels strongly reflects the influence of coincident product molecules emerging from this chemical reaction. The reaction is very direct and must proceed on a time scale which does not allow for efficient energy transfer into all the available phase space

Recording Cultural Heritage Using Terrestrial Laserscanning - Dealing with the System, the Huge Datasets they Create and Ways to Extract the Necessary Deliverables you can Work with

Science.gov (United States)

Christofori, E.; Bierwagen, J.

2013-07-01

Recording Cultural Heritage objects using terrestrial laserscanning becomes more and more popular over the last years. Since terrestrial Laserscanning System (TLS) Manufacturers have strongly increased the amount and speed of data captured with a single scan at each system upgrade and cutting down system costs the use of TLS Systems for recording cultural heritage is an option for recording worth to think about beside traditional methods like Photogrammetric. TLS Systems can be a great tool for capturing complex cultural heritage object within a short amount of time beside the traditional methods but can be a nightmare to handle for further process if not used right while capturing. Furthermore TLS Systems still have to be recognized as survey equipment, even though some of the manufactures promote them as everyday tool. They have to be used in an intelligent way having in mind the clients and the individual cultural objects needs. Thus the efficient way to use TLS Systems for data recording becomes a relevant topic to deal with the huge Amount of data the Systems collect while recording. Already small projects can turn into huge Pointcloud Datasets that End user, like Architects or Archaeologist neither can't deal with as their technical equipment doesn't fit the requirements of the Dataset nor do they have the software tools to use the Data as the current software tools still are high prized. Even the necessary interpretation of the Dataset can be a tough task if the people who have to work on with the Pointcloud aren't educated right in order to understand TLS and the results it creates. The use of TLS Systems has to have in mind the project requirements of the individual Heritage Object, like the required accuracy, standards for Levels of Details (e.g. "Empfehlungen für die Baudokumentation, Günther Eckstein, Germany"), the required kind of Deliverables (Visualization, 2D Drawings, True Deformation Drawings, 3D Models, BIM or 4D - Animations) as well as the

Populisme et démocratie semi-directe : la dénaturation des procédés référendaires en France et aux Etats-Unis

Directory of Open Access Journals (Sweden)

Christophe Premat

2005-09-01

Full Text Available Si le populisme se caractérise par l’incarnation d’un ensemble de frustrations à l’égard du système représentatif, il est primordial de s’interroger sur le lien entre une déception à l’égard des institutions et les instruments de démocratie semi-directe. En nous appuyant sur une comparaison entre la France et les Etats-Unis pour analyser d´une part comment le référendum et l’initiative populaire ont modifié la donne dans certains Etats américains et d’autre part comment en France les référendums nationaux ont connu la suspicion « plébiscitaire » à plusieurs reprises, nous souhaiterions comprendre si par nature la démocratie semi-directe n’est que le ressentiment engendré par la lenteur du travail de représentation ou si elle est le complément essentiel à la transformation du régime représentatif.Si la frustración contra el sistema representativo es expresada por el populismo, es crucial interrogarse por el acoplamiento entre una decepción relacionada con las instituciones y los instrumentos semidirectos de la democracia. Al comparar Francia con Estados Unidos con el objetivo de analizar por una parte, cómo las iniciativas populares y los referendums influenciaron la legislación de algunos estados americanos y por otra, cómo los referéndums nacionales en Francia fueron reducidos a plebiscitos, intentamos descifrar si la naturaleza de la democracia semidirecta es el resultado de un resentimiento contra la lentitud del trabajo representativo o si concluye la transformación del gobierno representativo.If the feelings of frustration against the representative system are expressed by populism, it is crucial to question the link between a disappointment vis-à-vis the institutions and the semi-direct democracy instruments. By comparing France and United States in order to analyze on the one hand how popular initiatives and referenda influenced the legislation of some American States and on the other

Shuttle orbiter Ku-band radar/communications system design evaluation. Deliverable test equipment evaluation

Science.gov (United States)

Maronde, R. G.

1980-07-01

The Ku-band test equipment, known as the Deliverable System Test equipment (DSTE), is reviewed and evaluated. The DSTE is semiautomated and computer programs were generated for 14 communication mode tests and 17 radar mode tests. The 31 test modules provide a good cross section of tests with which to exercise the Ku-band system; however, it is very limited when being used to verify Ku-band system performance. More detailed test descriptions are needed, and a major area of concern is the DSTE sell-off procedure which is inadequate.

RECORDING CULTURAL HERITAGE USING TERRESTRIAL LASERSCANNING – DEALING WITH THE SYSTEM, THE HUGE DATASETS THEY CREATE AND WAYS TO EXTRACT THE NECESSARY DELIVERABLES YOU CAN WORK WITH

Directory of Open Access Journals (Sweden)

E. Christofori

2013-07-01

Full Text Available Recording Cultural Heritage objects using terrestrial laserscanning becomes more and more popular over the last years. Since terrestrial Laserscanning System (TLS Manufacturers have strongly increased the amount and speed of data captured with a single scan at each system upgrade and cutting down system costs the use of TLS Systems for recording cultural heritage is an option for recording worth to think about beside traditional methods like Photogrammetric. TLS Systems can be a great tool for capturing complex cultural heritage object within a short amount of time beside the traditional methods but can be a nightmare to handle for further process if not used right while capturing. Furthermore TLS Systems still have to be recognized as survey equipment, even though some of the manufactures promote them as everyday tool. They have to be used in an intelligent way having in mind the clients and the individual cultural objects needs. Thus the efficient way to use TLS Systems for data recording becomes a relevant topic to deal with the huge Amount of data the Systems collect while recording. Already small projects can turn into huge Pointcloud Datasets that End user, like Architects or Archaeologist neither can't deal with as their technical equipment doesn't fit the requirements of the Dataset nor do they have the software tools to use the Data as the current software tools still are high prized. Even the necessary interpretation of the Dataset can be a tough task if the people who have to work on with the Pointcloud aren't educated right in order to understand TLS and the results it creates. The use of TLS Systems has to have in mind the project requirements of the individual Heritage Object, like the required accuracy, standards for Levels of Details (e.g. "Empfehlungen für die Baudokumentation, Günther Eckstein, Germany", the required kind of Deliverables (Visualization, 2D Drawings, True Deformation Drawings, 3D Models, BIM or 4D �

CRISP. Information Security Models and Their Economics

International Nuclear Information System (INIS)

Gustavsson, R.; Mellstrand, P.; Tornqvist, B.

2005-03-01

The deliverable D1.6 includes background material and specifications of a CRISP Framework on protection of information assets related to power net management and management of business operations related to energy services. During the project it was discovered by the CRISP consortium that the original description of WP 1.6 was not adequate for the project as such. The main insight was that the original emphasis on cost-benefit analysis of security protection measures was to early to address in the project. This issue is of course crucial in itself but requires new models of consequence analysis that still remains to be developed, especially for the new business models we are investigated in the CRISP project. The updated and approved version of the WP1.6 description, together with the also updated WP2.4 focus on Dependable ICT support of Power Grid Operations constitutes an integrated approach towards dependable and secure future utilities and their business processes. This document (D1.6) is a background to deliverable D2.4. Together they provide a dependability and security framework to the three CRISP experiments in WP3

Bioclim Deliverable D8b: development of the physical/statistical down-scaling methodology and application to climate model Climber for BIOCLIM Work-package 3

International Nuclear Information System (INIS)

2003-01-01

The overall aim of BIOCLIM is to assess the possible long term impacts due to climate change on the safety of radioactive waste repositories in deep formations. The main aim of this deliverable is to provide time series of climatic variables at the high resolution as needed by performance assessment (PA) of radioactive waste repositories, on the basis of coarse output from the CLIMBER-GREMLINS climate model. The climatological variables studied here are long-term (monthly) mean temperature and precipitation, as these are the main variables of interest for performance assessment. CLIMBER-GREMLINS is an earth-system model of intermediate complexity (EMIC), designed for long climate simulations (glacial cycles). Thus, this model has a coarse resolution (about 50 degrees in longitude) and other limitations which are sketched in this report. For the purpose of performance assessment, the climatological variables are required at scales pertinent for the knowledge of the conditions at the depository site. In this work, the final resolution is that of the best available global gridded present-day climatology, which is 1/6 degree in both longitude and latitude. To obtain climate-change information at this high resolution on the basis of the climate model outputs, a 2-step down-scaling method is designed. First, physical considerations are used to define variables which are expected to have links which climatological values; secondly a statistical model is used to find the links between these variables and the high-resolution climatology of temperature and precipitation. Thus the method is termed as 'physical/statistical': it involves physically based assumptions to compute predictors from model variables and then relies on statistics to find empirical links between these predictors and the climatology. The simple connection of coarse model results to regional values can not be done on a purely empirical way because the model does not provide enough information - it is both

Oxygen depth profiling using the 16O(d,α)14N nuclear reaction

International Nuclear Information System (INIS)

Khubeis, I.; Al-Rjob, R.

1997-01-01

The excitation function of the 16 O(d,α) 14 N nuclear reaction has been determined in the deuteron energy range of 0.88-2.28 MeV. Major resonances are observed at deuteron energies of 0.98, 1.31, 1.53, 1.60, 1.73 and 2.22 MeV. The present results show good agreement with those of Haase and Khubeis, however there is a shift of 60 keV in the first resonance compared with the measurements of Amsel. The use of a thin surface barrier detector (t=22 μm) and a bias voltage of +20 V coupled with a proper pile-up rejection circuit has allowed the determination of the oxygen depth profiling to a resolution of 16 nm for thick targets. This method is efficient in eliminating interferences from other nuclear reactions such as 16 O(d,p) 17 O and 12 C(d,p) 19 C, where emitted protons have severely obscured α-particles from the 16 O(d,α) 14 N reaction. A 1.08 MeV deuteron beam has been employed to increase the α-yield from the target. The target has been tilted at 70 to enhance depth resolution. This reaction is well suited for the determination of oxygen concentration in oxides of high temperature superconductors. (orig.)

Experiences from two local processes of debate and referenda on the issue of siting high level nuclear waste

International Nuclear Information System (INIS)

Drottz Sjoberg, B.M.

1998-01-01

Full text of publication follows: the paper summarizes results from two interview studies conducted in the communities of Storuman (1995) and Malaa (1997) in northern Sweden regarding whether to continue investigations of the areas for siting of a deep level repository for high level nuclear waste. Active, local participants in the work and discussions preceding each local referendum on the issue were asked to reflect on reasons and considerations related to their opinions, as well as the overall outcome for achieving a deeper understanding of the local processes. The first referendum (1995) yielded a strongly voiced rejection of continuing local investigations (72%), whereas the second (1997) referendum resulted in a marginally negative response (54%). A comparison of the results of the interview studies showed e.g. that the decision processes differed across communities, regarding both time interval and content, and that the local strategies and tactics related to the campaigns preceding the referenda differed. Among the similarities were the types of questions which remained unclear, often related to a long term perspective, e.g. risks and uncertainties regarding material reliability, access to and future safety of the repository, concern for future generations, national and international long-term decision procedures, and roles of responsibility. The discussion focuses on considerations around the issue of local vs. centralized political decisions and the tool provided by the referendum, and touches upon some issues which appeared rather paradoxical. (author)

Final Report on Pilot Studies / Final Report on Classroom Research with STEM and TESL Assessment

DEFF Research Database (Denmark)

Biel, Carmen; Wake, Jo Dugstad; Hesse, Friedrich

This Deliverable is the final report on pilot studies within the NEXT-TELL project (D6.7) and furthermore comprises the Deliverable on Classroom Research with STEM and TESL Assessment (D2.9) in order to avoid redundancies between those two Deliverables.......This Deliverable is the final report on pilot studies within the NEXT-TELL project (D6.7) and furthermore comprises the Deliverable on Classroom Research with STEM and TESL Assessment (D2.9) in order to avoid redundancies between those two Deliverables....

VARIASI ALEL DNA MIKROSATELIT AUTOSOM LOKUS D2S1338, D13S317 DAN D16S539 PADA MASYARAKAT DAYAK KAHARINGAN DI KOTA PALANGKA RAYA

Directory of Open Access Journals (Sweden)

Lucia Emy Octavia

2016-06-01

Full Text Available Penelitian ini dilakukan untuk mengetahui ragam alel masyarakat Dayak Kaharingan di Kota Palangka Raya.  DNA diekstraksi dari sel epitel mukosa mulut, dari 26 individu dengan metode fenol kloroform. DNA mikrosatelitautosom lokus D2S1338, D13S317 dan D16S539 diamplifikasi pada mesin PCR. Pengamatan hasil PCR dilakukan dengan Polyacrylamide Gel Electrophoresis (PAGE dan visualisasi DNA hasil PCR dengan pewarnaan perak nitrat.  Hasil penelitian ini menunjukkan terdapat 29 alel dari ketiga lokus yaitu lokus D2S1338 sebanyak 11 alel, serta masing-masing sembilan alel pada lokus D13S317 dan lokus D16S539. Nilai heterozigositas tertinggi terdapat pada lokus D2S1338 yaitu 0,8971 dengan kekuatan pembeda (PD 0,9682, diikuti lokus D13S317 dengan kekuatan pembeda 0,9339 dan lokus D16S539 dengan kekuatan pembeda 0,9226.

Bioclim Deliverable D6b: application of statistical down-scaling within the BIOCLIM hierarchical strategy: methods, data requirements and underlying assumptions

International Nuclear Information System (INIS)

2004-01-01

-study regions were identified, together with the additional issues which arise in applying these techniques to output from the BIOCLIM simulations. This preliminary work is described in this BIOCLIM technical note. It provides an overview of statistical down-scaling methods, together with their underlying assumptions and advantages/disadvantages. Specific issues relating to their application within the BIOCLIM context (i.e., application to the IPSL C M4 D snapshot simulations) are identified, for example, the stationarity issue. The predictor and predictand data sets that would be required to implement these methods within the BIOCLIM hierarchical strategy are also outlined, together with the methodological steps involved. Implementation of these techniques was delayed in order to give priority to the application of the rule-based down-scaling method developed in WP3 to WP2 EMIC output (see Deliverable D8a). This task was not originally planned, but has allowed more comprehensive comparison and evaluation of the BIOCLIM scenarios and down-scaling methods to be undertaken

D7.1 Quality Plan

DEFF Research Database (Denmark)

Ryberg, Thomas; Lee, Deirdre; Maglavera, Stavroula

2009-01-01

This deliverable includes a detailed description of the quality assurance process for the EATrain2 project, the initial results of the risk assessment and self-evaluation processes as well as a description of the peer-review process for ensuring qualitative deliverables....

Overview of magnet design options: Deliverable D5.1

CERN Document Server

AUTHOR|(CDS)2069265; Toral, Fernando

2016-01-01

This document describes the design options for 16 T superconducting dipole magnets for the FCC hadron collider explored in the frame of the activities of WP5. All options have been considered under comparable assumptions and managed using the same tools to ensure a correct judgement and comparison of their relevant pros and cons. Three baseline design configurations have been explored: 1) block-coils, 2) cosine-theta and 3) common-coils. A fourth option, the canted cosine-theta, has been initiated by Swiss (PSI, not part of EuroCirCol) and US (LBNL, EuroCirCol partner) laboratories. The studies show that, adopting a reference margin to the load line of 14 % and with reasonable assumptions on the conductor performance, the total amount of conductor needed for the entire collider is between 7.5 and 10 ktons. depending on the option. The cosine-theta uses less conductor and the canted cosine-theta uses the largest amount. The characterisation of the magnet design options is complete and the work to finalize and ...

Supplement to ACUMEN deliverable 5.4a: Description and comparison of indicators in Google Scholar and Web of Science

DEFF Research Database (Denmark)

Wildgaard, Lorna Elizabeth; Larsen, Birger; Schneider, Jesper

2014-01-01

of individual researchers. In this report we begin by comparing database coverage, coverage at seniority and gender-level and then the performance of four basic indicators computed in both databases. In the main deliverable 5.4a, we investigate in a cluster analysis the performance of our previously identified......We collected publication and citation data in two databases to investigate the extent performance of author-level indicators are effected by choice of database, the stability of indicators across databases and ultimately to illustrate how differences in the computed indicators change our perception...

Ensuring on-time quality data management deliverables from global clinical data management teams

Directory of Open Access Journals (Sweden)

Zia Haque

2010-01-01

Full Text Available The growing emphasis on off-site and off-shore clinical data management activities mandates a paramount need for adequate solutions geared toward on-time, quality deliverables. The author has been leading large teams that have been involved in successful global clinical data management endeavors. While each study scenario is unique and has to be approached as such, there are several elements in defining strategy and team structure in global clinical data management that can be applied universally. In this article, key roles, practices, and high-level procedures are laid out as a road map to ensure success with the model.

SU-F-BRB-07: A Plan Comparison Tool to Ensure Robustness and Deliverability in Online-Adaptive Radiotherapy

International Nuclear Information System (INIS)

Hill, P; Labby, Z; Bayliss, R A; Geurts, M; Bayouth, J

2015-01-01

Purpose: To develop a plan comparison tool that will ensure robustness and deliverability through analysis of baseline and online-adaptive radiotherapy plans using similarity metrics. Methods: The ViewRay MRIdian treatment planning system allows export of a plan file that contains plan and delivery information. A software tool was developed to read and compare two plans, providing information and metrics to assess their similarity. In addition to performing direct comparisons (e.g. demographics, ROI volumes, number of segments, total beam-on time), the tool computes and presents histograms of derived metrics (e.g. step-and-shoot segment field sizes, segment average leaf gaps). Such metrics were investigated for their ability to predict that an online-adapted plan reasonably similar to a baseline plan where deliverability has already been established. Results: In the realm of online-adaptive planning, comparing ROI volumes offers a sanity check to verify observations found during contouring. Beyond ROI analysis, it has been found that simply editing contours and re-optimizing to adapt treatment can produce a delivery that is substantially different than the baseline plan (e.g. number of segments increased by 31%), with no changes in optimization parameters and only minor changes in anatomy. Currently the tool can quickly identify large omissions or deviations from baseline expectations. As our online-adaptive patient population increases, we will continue to develop and refine quantitative acceptance criteria for adapted plans and relate them historical delivery QA measurements. Conclusion: The plan comparison tool is in clinical use and reports a wide range of comparison metrics, illustrating key differences between two plans. This independent check is accomplished in seconds and can be performed in parallel to other tasks in the online-adaptive workflow. Current use prevents large planning or delivery errors from occurring, and ongoing refinements will lead to

Deliverable 3.3.2 Specification of tests and test groups

DEFF Research Database (Denmark)

Peterson, Carrie Beth; Mitseva, Anelia; Harpur, Jill

2009-01-01

Deliverable 3.3.2: Specification of tests and test groups One of the main goals of the ISISEMD project is to offer innovative ICT services to improve the quality of life of elderly persons with cognitive problems or mild dementia and their informal and formal caregivers who provide every day care...... for them. This will be done via integrating intelligent scalable ICT services which will be tested for a period of 12 months under realistic conditions. Offering the services could not be complete without evaluating quality of life improvement, user acceptance and user satisfaction with a representative...... group of the target user groups. This document is devoted to describing important aspects of services evaluation such as: who the test participants will be, inclusion and exclusion criterion, selection standards, how the test participants will be recruited, ethical considerations, etc. Test methodology...

Variations in the D/H and 18O/16O ratios in cellulose extracted from a peat bog core

International Nuclear Information System (INIS)

Brenninkmeijer, C.A.M.; Mook, W.G.; Geel, B. van

1982-01-01

A peat core from a raised bog covering the period 3100 to 2400 14 C years B.P. has been analysed for D/H and 18 O/ 16 O ratios. These analyses were applied to cellulose, extracted from 56 successive layers of 1 cm thickness. D/H ratios were determined for the carbon bonded hydrogen; 18 O/ 16 O analyses were performed by applying a new method. For the interpretation of the results obtained on peat, the isotopic ratios of 11 living bog plant species were measured, showing a relatively large scatter. Most pronounced is a depletion in D of about 25per mille and in 18 O of about 5per mille of the Sphagnum mosses relative to the vascular bog plants. This different isotopic composition is reflected by the deltaD and delta 18 O records of the peat core, because the abundance of the remains of non-vascular plants is variable. If this effect is taken account of, the remaining deltaD variations appear to be too large to be attributed to variations in the isotopic compositions of precipitation. As palaeoclimatic indicators the D/H and 18 O/ 16 O ratio qualitatively agree with the pollen analytical evidence for the climatic deterioration of the Subboreal-Subatlantic transition. (orig.)

IM-16: A new microporous germanosilicate with a novel framework topology containing d4r and mtw composite building units

International Nuclear Information System (INIS)

Lorgouilloux, Yannick; Dodin, Mathias; Paillaud, Jean-Louis; Caullet, Philippe; Michelin, Laure; Josien, Ludovic; Ersen, Ovidiu; Bats, Nicolas

2009-01-01

The synthesis and the structure of IM-16 a new germanosilicate with a novel zeolitic topology prepared hydrothermally with the ionic liquid 3-ethyl-1-methyl-3H-imidazol-1-ium as the organic structure-directing agent are reported. The structure of calcined and partially rehydrated IM-16 of chemical formula |(H 2 O) 0.16 |[Si 3.47 Ge 2.53 O 12 ] was solved from powder XRD data in space group Cmcm with a=15.0861(2) A, b=17.7719(3) A, c=19.9764(3) A, V=5355.84(12) A 3 (Z=16). This new zeolite framework type contains 10-MRs channels and may be described from the d4r and mtw composite building units. - Graphical abstract: The synthesis and the structure of IM-16 a new germanosilicate with a novel zeolitic topology prepared hydrothermally with the ionic liquid 3-ethyl-1-methyl-3H-imidazol-1-ium as the organic structure-directing agent are reported. This new zeolite framework type contains 10-MRs channels and may be described from the d4r and mtw composite building units

Report of Case Studies on Gender Equality as a Focus Point of National and Nativist Discourses (Deliverable 9.7)

OpenAIRE

Siim, Birte; Kriszan, Andrea; Ámon, Kata; Knijn, Trudie; Broek, Hans Peter van den; Caponia, Tiziana; Gal, John; Halevy, Dana; Sipic, Josip; Unger, Brigitte

2016-01-01

The overall aim of WP9.7 is to analyse ‘cross-national case studies on gender equality as the focus of national and nativist discourses’. This deliverable is based on the national reports on the rhetoric of populist radical right parties from the seven selected countries, i.e. Croatia, Denmark, the Netherlands, Hungary, Germany, Italy and Spain, together with Israel. The objective of this synthesis report is to identify similarities and divergences in framing migration, mobility, gender and f...

Immunohistochemical comparison of cyclin D1 and P16 in odontogenic keratocyst and unicystic ameloblastoma

Directory of Open Access Journals (Sweden)

Seyed Mohammad Razavi

2013-01-01

Conclusion: Cyclin D1 did show a higher staining intensity in UAs compared to the keratocysts, although the expression of P16 was similar in the studied groups. The invasive growth of OKC might be related to the state of expression of cyclin D1 and P16 in the epithelium of this cyst.

16 CFR Appendix D5 to Part 305 - Water Heaters-Heat Pump

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Water Heaters-Heat Pump D5 Appendix D5 to Part 305 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULE... Appendix D5 to Part 305—Water Heaters—Heat Pump Range Information CAPACITY FIRST HOUR RATING Range of...

'Archers' of the Blessed City: City's Deliverance in the Coinage of Early Hellenistic Olbia

DEFF Research Database (Denmark)

Stolba, Vladimir

2015-01-01

Despite continuous and thorough studies of Olbian coinage, the chronology of some coin series produced by this Pontic city and the messages communicated by their types remain obscure. One such controversial issue, standing out from the total mass, is the so-called ‘archers’, the early Hellenistic...... with the major turning point in the city’s history, namely its deliverance from the siege laid by Macedonian troops in the course of Zopyrion’s campaign against the Scythians around 331 BC....

Preparation and characterization of 1,6 anhydrous Β-D-Glucopyranose from starch

International Nuclear Information System (INIS)

Alvarez Lopez, M.S.

1991-01-01

In order to prepare 2-deoxi-2-fluoride-D-glucosa (2FDG) in an inert form there are several synthesis methods, but the more interesting one for our study is based in a reaction from the 1,6 anhydrous, Β-D-glucopyranose (1,6AGP), in an attempt to compare the labelling efficiency rate of 2FDG with F-18, which is highly used in nuclear medicine. In the present paper the attainment of starch from white potatoe, infrared analysis of this starch and fusion point are included. Also results are compared with an analytical reactive standard. The process of preparation of 1,6AGP by pyrolysis of starch under reduced pressure, its separation and purification by crystallization and infrared characterization of 1,6AGP, nuclear magnetic resonance and mass spectrometry are also included. 10 kg. of potatoes were used, and 93059 g. ±5.8 of starch with an efficiency rate of 9.32 ±0.631; fusion point was 272 o C and there was a 9.83 ± 1.48 % of humidity. After the pyrolysis, crystallization an purification processes, 1.71 ±0.54 % of 1,6AGP were obtained. Later results of compound characterization, nuclear magnetic resonance, infrared and mass spectrometry were compared with a commercial product and it was proved that it corresponds to such pure compound. (Author)

BOMS-D-16-00569.pdf | forthcoming | boms | Volumes | public ...

Indian Academy of Sciences (India)

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BOMS-D-16-00821.pdf | forthcoming | boms | Volumes | public ...

Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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BOMS-D-16-00748.pdf | forthcoming | boms | Volumes | public ...

Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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BOMS-D-16-01004.pdf | forthcoming | boms | Volumes | public ...

Indian Academy of Sciences (India)

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BOMS-D-16-00728.pdf | forthcoming | boms | Volumes | public ...

Indian Academy of Sciences (India)

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BOMS-D-16-00015.pdf | forthcoming | boms | Volumes | public ...

Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Evaluation of dose prediction errors and optimization convergence errors of deliverable-based head-and-neck IMRT plans computed with a superposition/convolution dose algorithm

International Nuclear Information System (INIS)

Mihaylov, I. B.; Siebers, J. V.

2008-01-01

The purpose of this study is to evaluate dose prediction errors (DPEs) and optimization convergence errors (OCEs) resulting from use of a superposition/convolution dose calculation algorithm in deliverable intensity-modulated radiation therapy (IMRT) optimization for head-and-neck (HN) patients. Thirteen HN IMRT patient plans were retrospectively reoptimized. The IMRT optimization was performed in three sequential steps: (1) fast optimization in which an initial nondeliverable IMRT solution was achieved and then converted to multileaf collimator (MLC) leaf sequences; (2) mixed deliverable optimization that used a Monte Carlo (MC) algorithm to account for the incident photon fluence modulation by the MLC, whereas a superposition/convolution (SC) dose calculation algorithm was utilized for the patient dose calculations; and (3) MC deliverable-based optimization in which both fluence and patient dose calculations were performed with a MC algorithm. DPEs of the mixed method were quantified by evaluating the differences between the mixed optimization SC dose result and a MC dose recalculation of the mixed optimization solution. OCEs of the mixed method were quantified by evaluating the differences between the MC recalculation of the mixed optimization solution and the final MC optimization solution. The results were analyzed through dose volume indices derived from the cumulative dose-volume histograms for selected anatomic structures. Statistical equivalence tests were used to determine the significance of the DPEs and the OCEs. Furthermore, a correlation analysis between DPEs and OCEs was performed. The evaluated DPEs were within ±2.8% while the OCEs were within 5.5%, indicating that OCEs can be clinically significant even when DPEs are clinically insignificant. The full MC-dose-based optimization reduced normal tissue dose by as much as 8.5% compared with the mixed-method optimization results. The DPEs and the OCEs in the targets had correlation coefficients greater

Guidance on a better integration of aquaculture, fisheries, and other activities in the coastal zone: from tools to practical examples

NARCIS (Netherlands)

Stelzenmüller, V.; Schulze, T.; Gimpel, A.; Bartelings, H.; Bello, E.; Bergh, O.; Bolman, B.; Caetano, M.; Davaasuren, N.; Fabi, G.; Ferreira, J.G.; Gault, J.; Gramolini, R.; Grati, F.; Hamon, K.G.; Jak, R.G.; Kopke, K.; Laurans, M.; Mäkinen, T.; O’Donnell, V.; O’Hagan, A.M.; O’Mahony, C.; Oostenbrugge, van H.; Ramos, J.; Saurel, C.; Sell, A.L.; Silvo, K.; Sinschek, K.; Soma, K.; Stenberg, C.; Taylor, N.; Vale, C.; Vasquez, F.; Verner-Jeffreys, D.W.

2013-01-01

This guidance document provides a comprehensive assessment of the conflicts and synergies between fisheries, aquaculture and other activities in the coastal zone in six COEXIST case study areas. It forms deliverable D5.2 of the COEXIST project and synthesises deliverable D5.1, which provides a more

TU-C-17A-06: Evaluating IMRT Plan Deliverability Via PTV Shape and MLC Motion

International Nuclear Information System (INIS)

McGurk, R; Smith, VA; Price, M

2014-01-01

Purpose: For step-and-shoot intensity-modulated radiation therapy (IMRT) plans, the dosimetry and deliverability can be affected by the number and shape of the segments used. Thus, plan deliverability is likely related to target volume and shape. We investigated whether the sphericity of target volumes and the previously proposed Modulation Complexity Score (MCS) could be used together to improve the detection of IMRT fields that failed quality assurance (QA). Methods: 526 and 353 IMRT fields from 32 prostate and 28 head-and-neck (H'N) patients, respectively, were analyzed. MCS was used to quantify the complexity of multi-leaf collimator shapes and motion patterns for each field. Sphericity was calculated using the surface area and volume of each patient’s planning target volume (PTV). Logistic regression models with MCS-alone or MCS and sphericity terms were fit to PlanUNC IMRT pass/fail results (5% dose difference, 4mm distance-to-agreement criteria) using SAS 9.3 (Cary, NC). Model concordance, discordance and area under the curve (AUC) were used to quantify model accuracy. Results: Mean (±1 standard deviation) MCS for prostate and H'N were 0.58(±0.15) and 0.40 (±0.14), respectively. Mean sphericity scores were 0.75(±0.05) for prostate and 0.63 (±0.12) for H'N. Both metrics were significantly different between treatment locations (p<0.01, Wilcoxon Rank Sum Test) indicating greater complexity in shape and variations for H'N PTVs. For prostate, concordance, discordance and AUC using MCS alone were 80.8%, 18.7% and 0.811. Including sphericity in the model improved these to 81.7%, 17.7% and 0.820. For H'N, the original concordance, discordance and AUC were of 72.9%, 26.9% and 0.729. Including sphericity into the model improved these metrics to 76.5%, 23.2% and 0.729. Conclusion: Sphericity provides a quantitative measure of PTV shape. While improvement in IMRT QA failure detection was modest for both prostate and H'N plans

High prevalence of vitamin D deficiency among children aged 1 month to 16 years in Hangzhou, China

Directory of Open Access Journals (Sweden)

Zhu Zhiwei

2012-02-01

Full Text Available Abstract Background Recent studies have suggested that vitamin D deficiency in children is widespread. But the vitamin D status of Chinese children is seldom investigated. The objective of the present study was to survey the serum levels of 25-hydroxyvitamin D [25(OHD] in more than 6,000 children aged 1 month to 16 years in Hangzhou (latitude: 30°N, the capital of Zhejiang Province, southeast China. Methods The children aged 1 month to 16 years who came to the child health care department of our hospital, the children's hospital affiliated to Zhejiang university school of medicine, for health examination were taken blood for 25(OH D measurement. Serum 25(OH D levels were determined by direct enzyme-linked immunosorbent assay and categorized as Results A total of 6,008 children aged 1 month to 16 years participated in this cross-sectional study. All the subjects were divided into subgroups according to their age: 0-1y, 2-5y, 6-11y and 12-16y representing infancy, preschool, school age and adolescence stages respectively. The highest mean level of serum 25(OHD was found in the 0-1y stage (99 nmol/L and the lowest one was found in 12-16y stage (52 nmol/L. Accordingly, the prevalence of serum 25(OHD levels of Conclusions The prevalence of vitamin D deficiency and insufficiency among children in Hangzhou Zhejiang province is high, especially among children aged 6-16 years. We suggest that the recommendation for vitamin D supplementation in Chinese children should be extended to adolescence.

Police Enforcement Policy and Programmes on European Roads (PEPPER). Deliverable 4a: Good practice in data, data collection and data use for monitoring and evaluating Traffic Law Enforcement.

NARCIS (Netherlands)

Schagen, I.N.L.G. Bernhoft, I.M. Erke, A. Ewert, U. Kallberg, V.-P. & Skladana, P.

2008-01-01

This report is the Deliverable of task 4.3a of the PEPPER project. It describes the good practice requirements regarding data, data collection and data use for monitoring and evaluating Traffic Law Enforcement (TLE). The aim is that, eventually, individual police forces/countries put the identified

Clinicopathological significance of p16, cyclin D1, Rb and MIB-1 levels in skull base chordoma and chondrosarcoma

Directory of Open Access Journals (Sweden)

Jun-qi Liu

2015-09-01

Full Text Available Objective: To investigate the expression of p16, cyclin D1, retinoblastoma tumor suppressor protein (Rb and MIB-1 in skull base chordoma and chondrosarcoma tissues, and to determine the clinicopathological significance of the above indexes in these diseases. Methods: A total of 100 skull base chordoma, 30 chondrosarcoma, and 20 normal cartilage tissue samples were analyzed by immunohistochemistry. The expression levels of p16, cyclinD1, Rb and MIB-1 proteins were assessed for potential correlation with the clinicopathological features. Results: As compared to normal cartilage specimen (control, there was decreased expression of p16, and increased expression of cyclin D1, Rb and MIB-1 proteins, in both skull base chordoma and chondrosarcoma specimens. MIB-1 LI levels were significantly increased in skull base chordoma specimens with negative expression of p16, and positive expression of cyclin D1 and Rb (P  0.05. However, p16 and MIB-1 levels correlated with the intradural invasion, and expression of p16, Rb and MIB-1 correlated with the number of tumor foci (P < 0.05. Further, the expression of p16 and MIB-1 appeared to correlate with the prognosis of patients with skull base chordoma. Conclusions: The abnormal expression of p16, cyclin D1 and Rb proteins might be associated with the tumorigenesis of skull base chordoma and chondrosarcoma. Keywords: p16, Cyclin D1, Rb, MIB-1, Skull base chordoma, Skull base chondrosarcoma

OPTIMISE - Deliverable D7.3

DEFF Research Database (Denmark)

Eriksen, Morten

This report describes the final conclusion on rolling, pressing and filament geometry. The most of the work has previous been described and present in the work package reports that has been made during the project and presented at the 6 months meeting. This report is built up in such a way......, that the main investigations and conclusions on rolling, pressing and filament geometry will be presented in separate parts. In the end of this reports the main recommendations for the mechanical processing will be given....

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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D 6.1 Interim biocomposite evaluation review

OpenAIRE

Pinto, A.; Tjeerdsma, B.; Pina dos Santos, C.; Perremans, D.; Carra, G.; Bermejo, J.; Custódio, J.; Viegas, J.; Patrício, J.; Dzalto, J.; Ribeiro Nunes, L. M.; Real, L. P.; Veras, M.; Rodrigues, M. P.

2013-01-01

Este registo pertence ao Repositório Científico do LNEC This deliverable is a review report which evaluates the progress and feasibility of the biocomposite systems, designs and installations, taking into account the information resulting from the work developed in the aim of Biobuild project. The main steps followed in the project up to this moment to develop bio-systems with such characteristics can be summarized as follows: · Use of additives and modifications to create d...

Deliverable 2.2

DEFF Research Database (Denmark)

Tarabanis, Konstantinos; Efthimios, Tambouris; Zotou, Maria

2016-01-01

etc. The report also presents the OD-PBL design pathway, which is a further development of the OD-PBL methodological recommendations presented in the D2.1. This design pathway aims to guide educators when designing learning processes that aim to teach OD by utilizing the PBL learning strategy......The work carried out resulted in the description of the LA field and in the presentation of a total of 18 LA tools that can analyse educational data that can be utilized in the project to support multiple PBL aspects, such as feedback, reflection, self-driven learning, collaboration, application....... The pathway consists of 6 main steps, i.e. Analysis, Gathering of inputs, Design, Development, Implementation and Reflection. Each step provides guidelines on how to plan an OD course and learning processes, and combines all previous project results from D1.1, D1.2, D1.3 and D2.1. Finally, the report presents...

Deliverable 7.1: Legal Framework and Legal Barriers to an Offshore HVDC Electricity Grid in the North Sea : Intermediate Report for Stakeholder Review

NARCIS (Netherlands)

Nieuwenhout, C.T.

The present deliverable elaborates the current legal framework for offshore wind and grid development on international, European and national level. It is shown that often, the legal framework needs to be adapted in order to facilitate the development of a meshed offshore electricity grid. This is

Night Wind - Deliverable D.3.2 main simulation report; Grid architecture for wind power production with energy storage through load shifting in refrigerated warehouses

Energy Technology Data Exchange (ETDEWEB)

Cronin, Tom; Bindner, Henrik; Zong, Yi

2008-11-15

This report represents Deliverable D.3.2 of Work Package 3 in the Night Wind project. The aim of this Work Package was to simulate a cold store (or number of cold stores) within a power system where there is a high degree of wind power penetration. The Night Wind Control System, developed as part of Work Package 5, was to be integrated into the simulations so that the wind power could be 'stored' in the cold store with maximum benefit to the electrical network, utility or cold store owner. To this end, the following have been accomplished: 1) The Night Wind concept has been described in terms of demand side management. 2) Input requirements and data have been specified and collected. Measured data from the existing cold store facility of Partner Logistics has been analysed. 3) Component models for the simulations (including the cold store model itself) have been developed for the simulation platform, IPSYS. 4) The Night Wind Control System (NWCS) from Work Package 5 has been developed so that it finishes computations within two minutes. 5) Controllers including the NWCS) have been operated with the cold store model within IPSYS. 6) Simulations have been performed with the cold store model and an increasing penetration of wind power. This report presents the results of the work undertaken in Work Package 3 which would have benefited from the additional time requested at the project meeting in March 2008, however, this extension of time was not granted. Nevertheless, the work that was possible is considered significantly complete, although it is acknowledged that there has been a delay in the presentation of this report. It should be noted that it was not possible to address the new aspects of Task 3.7 'Verification of simulation results' as there was no implementation of the night wind concept at the demonstration site (Task 7). Verification of the simulation of the present system has, naturally, been carried out and described in this report. (ln)

The culture of referendum in Albania: Technical and theoritecal reflections on the abrogative referendum

Directory of Open Access Journals (Sweden)

Valbona Pajo Bala

2014-01-01

Full Text Available The aim of this paper is to analyse the Albanian constitutional and legal framework on referenda, in general, focusing special attention to the abrogative referenda of a law or part thereof. Given the absence of any concrete case of an abrogative referenda held in Albania, which does not creates very much room for discussion in that regard, the paper, through a comparative approach on the referenda culture in other european states, aims at offering to the reader a more complete view on the mechanisms and guarantees enjoyed by voters and the effective way of their use, in order to give life to the direct democracy, but without replacing the representative one. In addition, part of the analyses will be the powers of the Constitutional Court for the ex ante constitutional review of the issue subject to a referendum, the review of constitutionality of the referndum and of its results. In this context, the paper will focus on the constitutional case-law as a tool for increasing the referenda culture and shaping the constitional order, as well as a source of standards and values. Another objective of the paper is to open a discussion on the need for the reception of referenda-related standards elaborated in those European countries, where the culture of helding a referenda and the case-law on the regard is enriched and may serve as a qualitative basis for further reference.

Construction of a bi parametric analysis system. Application to the study of the decay of the 16.11 MeV level of {sup 12}C; Realisation d'un ensemble d'analyse biparametrique. Application a l'etude de la desintegration du niveau de 16,11 MeV du {sup 12}C

Energy Technology Data Exchange (ETDEWEB)

Engelhardt, H D [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1966-11-15

A baroreceptor analysis system has been assembled to measure {alpha}-{alpha} spectra in coincidence (resolution 2 {tau} = 10 ns). The correlations in energy and angle of the {alpha}-particles emitted from the reaction {sup 11}B(p,{alpha}) have been studied using 163 keV protons produced by a Van-de-Graaff accelerator. Evidence has been obtained for the sequential decay of {sup 12}C{sup *} (16.11 MeV) via the 0{sup +} and 2{sup +} states of {sup 8}Be. Contributions from the {sup 8}Be{sup *}(4{sup +}) level or from the simultaneous break-up of {sup 12}C{sup *} (16.11 MeV) into three {alpha}-particles cannot be excluded. (author) [French] On a mis au point un dispositif d'analyse biparametrique de spectres {alpha}-{alpha} en coincidences (resolution 2 {tau} = 10 ns). On a etudie, a l'aide de ce dispositif et d'un accelerateur Van de Graaff la correlation d'energie et angulaire entre les particules a de la reaction {sup 11}B(p,{alpha}) a une energie de protons E{sub p} = 163 keV. On a mis en evidence la desintegration sequentielle du {sup 12}C{sup *} (16.11 MeV) par les etats (0{sup +} et 2{sup +}) du {sup 8}Be. La contribution d'un niveau (4{sup +}) du {sup 8}Be{sup *} ou d'une desintegration simultanee du {sup 12}C{sup *} (16,11 MeV) en 3 {alpha} ne peut pas etre exclue. (auteur)

Systematic study of (d,n) reactions at Ed = 16 MeV using a deuterated scintillator array

International Nuclear Information System (INIS)

Febbraro, M.; Becchetti, F.D.; Torres-Isea, R.O.; Riggins, A.; Lawrence, C.; Howard, A.M.; Kolata, J.J.

2014-01-01

We have developed a multi-element deuterated liquid scintillator array for the study of reactions involving neutrons utilizing high-speed digital signal processing. The liquid organic scintillators exhibit good digital pulse shape discrimination (DPSD). Typical configuration involves the detectors fixed to adjustable aluminium mounts, secured to an 80/20 aluminium frame. This allows for quick and adaptable configurations to be made for varying experimental conditions including measurements over a large angular range. A systematic study of (d,n) reactions at E d = 16 MeV on 9 Be, 11 B, 13 C, 14 N, 15 N, and 19 F has been conducted from 10 to 160 degrees (lab). In addition to previously unmeasured back-angle cross sections, this data can complement existing and future ( 3 He,d) measurements as an analog to (p,γ) for astrophysics applications

Preliminary guidelines for priority setting between measures, Deliverable 3.4 of the H2020 project SafetyCube (Safety CaUsation, Benefits and Efficiency).

NARCIS (Netherlands)

Martensen, H. Van den Berghe, W. Wijnen, W. Weijermars, W.A.M. Carnis, L. & Elvik, R.

2017-01-01

The present deliverable describes the economic assessment of counter measures. Cost-effectiveness analysis and cost-utility analysis are compared to cost-benefit analysis. Cost-effectiveness analysis helps to estimate the costs per prevented fatality or injury. To evaluate the effectiveness in terms

Homologation of hexopyranosides: use of differential Overhauser nuclear effect, and homo- and heteronuclear correlations of chemical shift for characterization of the 1,6-anhydro-4-O-benzoyl-2,3-didesoky-3-C-trifluoroacetamidomethyl-{beta}-D-m = ethyl ribopyranoside (16a); Homologacao de hexopiranosideos: utilizacao de efeito nuclear overhauser diferencial e de correlacoes homo e heteronuclear de deslocamentos quimicos para a caracterizacao do 1,6-anidro-4-O-benzoil-2,3-didesoxi-3-C- trifluoroacetamidometil-{beta}-D-ribo piranosideo de metila (16a)

Energy Technology Data Exchange (ETDEWEB)

Souza Filho, J D; Silva, L.G. Fonseca e; Oliveira, A Braga de; Alves, R Jose [Minas Gerais Univ., Belo Horizonte, MG (Brazil); Lukacs, G [Centre National de la Recherche Scientifique (CNRS), 91 - Gif-sur-Yvette (France). Inst. de Chimie des Substances Naturelles

1992-12-31

The discovery of ramified sugars as various antibiotics constituents, leads to the development of various preparation technologies. In the framework of hexa pyranose analogues synthesis, the 1,6-anhydride -16a was one of the byproducts obtained in the attempt of bromide -16 derivative transformation in the iodate -6-1 derivative. The bromide -16 derivative was treated with 2 equivalents of Bu{sub 4} N I during 24 hours, acetonitrile reflux. 3 parts of 2 Bu{sub 4} N I equivalents were added each 24 hours. A unique pure substance was obtained from the formed products mixture, which the structural determination was proposed in accordance with: 1) disappearing of the C-13 signal and the two protons from the anomeric methoxy group, and 2) registering of the molecular ion with m/z 359D, corresponding to the loss of 94D (Br + C H{sub 3}), from the -16 (M{sup +}., m/z 453D). The 1,6-anhydride -16a structure was confirmed by experiments on homo- and heteronuclear correlations of chemical shifts (COSY H-H and COSY C-H), and by spectroscopy using the differential Overhauser nuclear effect. The spectrum obtained by C-H correlation identified the singlet at 5.65 ppm as due to the H-1 ([C-1 x H-1]) 2 refs., 6 figs.

From Field Work to Deliverables. Experiences on the Tin House Courtyard Documentation

Science.gov (United States)

Bello Caballero, L.; Mezzino, D.; Federman, A.; Santana Quintero, M.

2017-08-01

The Tin House Courtyard is a property of the National Capital Commission (NCC) in Ottawa, Canada. The site is located within the `Mile of History', a historical route running from Parliament Hill to the Governor General's residence. Currently, existing assets are under intervention works that include several preservation and renewal actions. Within the broader project, one of the tasks before construction works started was the documentation of the set of facades. The Carleton Immersive Media Studio (CIMS) at Carleton University in Ottawa was commissioned by NCC to conduct the recording of the area. This paper describes the process undertaken from field work to the final deliverable to the client, as well as the issues faced in between. Nowadays, up to date surveying technologies have revolutionized the methodologies for cultural heritage documentation. In this regard, the recording strategy employed encompassed the use of photogrammetry, laser scanner, total station, as well as different pre and post processing software in order to generate the desired outcomes.

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JESS-D-16-00067 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00247 R4.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00399R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00343 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00608 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00589 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00170 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00450 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00500 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00284 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00510 R4.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00578 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00339 R3.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00482 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00418 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00199 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00571 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00396 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00266R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00405 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00096 R4.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00127R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00307 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00302 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00485 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00428 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00537 R3.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00082 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00429 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00657 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00330 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00503 R3.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00409 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00287 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00370 R3.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00451R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00508 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00457 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00197 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00432 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00583 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00331R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00216R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00462 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00615 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00069 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00237 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00189 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00274 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00379 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00392 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00575 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00024 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00024 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00205R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00023 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00602 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00602 R1.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00528 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00523 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00354R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00272 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00043 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00107 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00107 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00032 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

Home; public; Volumes; jess; forthcoming; JESS-D-16-00032 R2.pdf. 404! error. The page your are looking for can not be found! Please check the link or use the navigation bar at the top. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

JESS-D-16-00351 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00313 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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JESS-D-16-00432 R1.pdf;Structural | forthcoming | jess | Volumes ...

Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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JESS-D-16-00044 R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00034 R3.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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JESS-D-16-00005R2.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00389 R3.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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JESS-D-16-00496 R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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Indian Academy of Sciences (India)

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JESS-D-16-00154R1.pdf | forthcoming | jess | Volumes | public ...

Indian Academy of Sciences (India)

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REPAiR: REsource Management in Peri-urban AReas: Going Beyond Urban Metabolism : D 8.6 Detailed Dissemination Plan and Dissemination Kit

NARCIS (Netherlands)

Cerić, Dennis; Amenta, L.; Attademo, Anna

2017-01-01

The Detailed Dissemination Plan and Dissemination Kit is a strategic document for the beneficiaries helping them to establish the bases for their dissemination activities. It is a more detailed version of the Basic Dissemination Plan and Corporate Identity, deliverables of the REPAiR project D 8.3

Risk of injury by driving with alcohol and other drugs. Driving under the Influence of Drugs, Alcohol and Medicines DRUID, Deliverable 2.3.5.

NARCIS (Netherlands)

Hels, T. Bernhoft, I.M. Lyckegaard, A. Houwing, S. Hagenzieker, M.P. Legrand, S.-A. Isalberti, C. Van der Linden, T. & Verstraete, A.

2011-01-01

The objective of this deliverable is to assess the risk of driving with alcohol, illicit drugs and medicines in various European countries. In total nine countries participated in the study on relative risk of serious injury/fatality while positive for psychoactive substances. Six countries

Numerical modeling and experimental testing of a wave energy converter: deliverable D4.2

Energy Technology Data Exchange (ETDEWEB)

Zurkinden, A.S.; Kramer, M.; Ferri, F.; Kofoed, J.P.

2013-05-15

The objective of this document is to summarize the outcome of the research which has been carried out during the period May 2011 until June 2012 i.e. during the first year of the PhD study. The work has been done in collaboration with the co-authors. The aim of the project was primarily to provide numerical values for comparison with the experimental test results which were carried out in the same time. It is for this reason why Chapter 4 does consist exclusively of numerical values. Experimental values and measured time series of wave elevations have been used throughout the report in order to a) validate the numerical model and b) preform stochastic analysis. The latter technique is introduced in order to optimize the control parameters of the power take off system. (Author)

Developing a Low-Cost System for 3d Data Acquisition

Science.gov (United States)

Kossieris, S.; Kourounioti, O.; Agrafiotis, P.; Georgopoulos, A.

2017-11-01

In this paper, a developed low-cost system is described, which aims to facilitate 3D documentation fast and reliably by acquiring the necessary data in outdoor environment for the 3D documentation of façades especially in the case of very narrow streets. In particular, it provides a viable solution for buildings up to 8-10m high and streets as narrow as 2m or even less. In cases like that, it is practically impossible or highly time-consuming to acquire images in a conventional way. This practice would lead to a huge number of images and long processing times. The developed system was tested in the narrow streets of a medieval village on the Greek island of Chios. There, in order to by-pass the problem of short taking distances, it was thought to use high definition action cameras together with a 360˚ camera, which are usually provided with very wide-angle lenses and are capable of acquiring images, of high definition, are rather cheap and, most importantly, extremely light. Results suggest that the system can perform fast 3D data acquisition adequate for deliverables of high quality.

Oxygen mask fit analysis in F-16 fighter pilots using 3D imaging

NARCIS (Netherlands)

Schreinemakers, J.R.C.; Oudenhuijzen, A.J.K.; Amerongen, P.C.G.M. van; Kon, M.

2013-01-01

Background: The majority of Dutch F-16 pilots experience in-flight oxygen mask related nasal discomfort and injury. We aimed to analyze the fit of the oxygen mask. Methods: We successfully scanned 35 pilots with a 3D scanner to measure the distance between the contact area on the nose and the oxygen

CO2-emission trading and green markets for renewable electricity. Wilmar - deliverable 4.1

DEFF Research Database (Denmark)

Azuma-Dicke, N.; Morthorst, Poul Erik; Ravn, H.F.

2004-01-01

This report is Deliverable 4.1 of the EU project “Wind Power Integration in Liberalised Electricity Markets” (WILMAR) and describes the application of two policy instruments, Tradable Emissions Permits (TEP’s) and Tradable Green Certificates (TGC’s) forelectricity produced from renewable energy...... sources in the European Union and the implications for implementation in the Wilmar model. The introduction of a common emission-trading system in the EU is expected to have an upward effect on the spot pricesat the electricity market. The variations of the spot price imply that some types of power...... generation may change the situation from earning money to losing money despite the increasing spot price. Heavy restrictions on emissions penalise thefossil-fuelled technologies significantly, and the associated increase in the spot price need not compensate for this. Therefore, a market of TEP’s is expected...

OSSMETER D3.2 – Report on Source Code Activity Metrics

NARCIS (Netherlands)

J.J. Vinju (Jurgen); A. Shahi (Ashim)

2014-01-01

htmlabstractThis deliverable is part of WP3: Source Code Quality and Activity Analysis. It provides descriptions and initial prototypes of the tools that are needed for source code activity analysis. It builds upon the Deliverable 3.1 where infra-structure and a domain analysis have been

H2020 692819 SIMPATICO - D1.1: Project Management Plan

OpenAIRE

Forner, Pamela; Gerosa, Matteo; Folograna, Antonio

2017-01-01

This document is the deliverable “D1.1 – Project Management Plan” of the European project “SIMPATICO - SIMplifying the interaction with Public Administration Through Information technology for Citizens and cOmpanies” (hereinafter also referred to as “SIMPATICO”, project reference: 692819). The SIMPATICO Project Management Plan (PMP) is the main planning document and describes how major aspects of the project are managed, monitored and controlled. It is intended to provide gu...

The role of compensation in nuclear waste facility siting. A literature review and real life examples. Deliverable D16b

International Nuclear Information System (INIS)

Kojo, Matti; Richardson, P.J.

2009-10-01

The main objective of this report is to introduce and analyse the local decision-making process in the Eurajoki municipality, Finland regarding the siting of the SNF facility, within the framework of compensation theory. The compensation case Eurajoki offers excellent empirical data for analyzing how the negotiations on compensation were implemented at the local level. The successful siting process is particularly interesting as a number of survey studies have suggested that compensation for a radioactive waste repository does not change the percentage of individuals supporting the facility. On the contrary, some compensation proposals have even decreased the existing support. Even among hazardous waste facilities radioactive waste facilities seem to be an exception. The explanation offered is that radioactive waste is regarded with a greater sense of dread than is the case for other hazardous waste. Although monetary incentives and other benefits have been widely applied in the field of nuclear waste management in many countries the conclusion drawn is that compensation-based siting has to date experienced little success. However, two recent examples, one from Finland and the other from Korea, indicate that compensation can play a decisive role in decision-making during the siting of radioactive waste facilities. Furthermore, in Sweden a local benefit package was agreed between the nuclear waste management company SKB AB and the two candidate municipalities, Oskarshamn and Oesthammar in 2009 before the company announced the site. The novel aspect of this arrangement is that the municipality in which the facility is not located (now known to be Oskarshamn) will receive 75% of the total benefit package (around Euro 200 million) given that Oesthammar will receive all the attendant benefits associated with facility development. The main questions posed in this report are as follows: Why was the compensation package a success in the case of Eurajoki? What were the

E6D25E, HPV16 Asian variant shows specific proteomic pattern correlating in cells transformation and suppressive innate immune response

International Nuclear Information System (INIS)

Chopjitt, Peechanika; Pientong, Chamsai; Sunthamala, Nuchsupha; Kongyingyoes, Bunkerd; Haonon, Ornuma; Boonmars, Thidarut; Kikawa, Satomi; Nakahara, Tomomi; Kiyono, Tohru; Ekalaksananan, Tipaya

2016-01-01

HPV16 Asian variant (HPV16As) containing E6D25E oncogene, is commonly associated with cervical cancers of Asian populations. To explore a mechanism of E6D25E oncoprotein in carcinogenesis, we compared protein profiles in human keratinocytes expressing E6D25E with E6 of HPV16 prototype (E6Pro). A human cervical keratinocyte cell line, HCK1T, was transduced with retroviruses containing E6D25E or E6Pro genes. Biological properties of E6D25E or E6Pro transduced HCK1T cells were characterized. Protein profiles of the transduced HCK1T cells were analyzed using 2D-PAGE and characterized by mass spectrometry and western blotting. Reactomes of modulated proteins were analyzed by using the Reactome Knowledgebase. The E6D25E and E6Pro oncoproteins were comparable for their abilities to degrade p53 and suppress the induction of p21, and induce cell proliferation. Interestingly, the protein profiles of the HCK1T cells transduced with E6D25E showed specific proteomic patterns different from those with E6Pro. Among altered proteins, more than 1.5-fold up- or down- regulation was observed in E6D25E-expressing cells for gp96 and keratin7 which involved in activation of TLR signaling and transformation of squamocolumnar junction cells, respectively. This report describes new cellular proteins specifically targeted by E6D25E oncoprotein that may contribute to impair immune response against viral infection and cell transformation associated with oncogenic property of HPV16As variant. - Highlights: • E6D25E HPV16 specifically modulates protein profile of human keratinocytes. • E6D25E HPV16 modulates protein profile which involves in TLR signalling and transformation of squamocolumnar junction cells. • E6D25E oncoprotein may correlate to impair of immune response against viral infection and cells transformation.

E6D25E, HPV16 Asian variant shows specific proteomic pattern correlating in cells transformation and suppressive innate immune response

Energy Technology Data Exchange (ETDEWEB)

Chopjitt, Peechanika; Pientong, Chamsai; Sunthamala, Nuchsupha [Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002 (Thailand); HPV & EBV and Carcinogenesis Research Group, Khon Kaen University (Thailand); Kongyingyoes, Bunkerd [Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002 (Thailand); Haonon, Ornuma; Boonmars, Thidarut [Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002 (Thailand); Kikawa, Satomi; Nakahara, Tomomi [Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 (Japan); Kiyono, Tohru, E-mail: tkiyono@ncc.go.jp [Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045 (Japan); Ekalaksananan, Tipaya, E-mail: tipeka@kku.ac.th [Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002 (Thailand); HPV & EBV and Carcinogenesis Research Group, Khon Kaen University (Thailand)

2016-09-09

HPV16 Asian variant (HPV16As) containing E6D25E oncogene, is commonly associated with cervical cancers of Asian populations. To explore a mechanism of E6D25E oncoprotein in carcinogenesis, we compared protein profiles in human keratinocytes expressing E6D25E with E6 of HPV16 prototype (E6Pro). A human cervical keratinocyte cell line, HCK1T, was transduced with retroviruses containing E6D25E or E6Pro genes. Biological properties of E6D25E or E6Pro transduced HCK1T cells were characterized. Protein profiles of the transduced HCK1T cells were analyzed using 2D-PAGE and characterized by mass spectrometry and western blotting. Reactomes of modulated proteins were analyzed by using the Reactome Knowledgebase. The E6D25E and E6Pro oncoproteins were comparable for their abilities to degrade p53 and suppress the induction of p21, and induce cell proliferation. Interestingly, the protein profiles of the HCK1T cells transduced with E6D25E showed specific proteomic patterns different from those with E6Pro. Among altered proteins, more than 1.5-fold up- or down- regulation was observed in E6D25E-expressing cells for gp96 and keratin7 which involved in activation of TLR signaling and transformation of squamocolumnar junction cells, respectively. This report describes new cellular proteins specifically targeted by E6D25E oncoprotein that may contribute to impair immune response against viral infection and cell transformation associated with oncogenic property of HPV16As variant. - Highlights: • E6D25E HPV16 specifically modulates protein profile of human keratinocytes. • E6D25E HPV16 modulates protein profile which involves in TLR signalling and transformation of squamocolumnar junction cells. • E6D25E oncoprotein may correlate to impair of immune response against viral infection and cells transformation.

Chromosome 16 microdeletion in a patient with juvenile neuronal ceroid lipofuscinosis (Batten disease)

NARCIS (Netherlands)

Taschner, P. E.; de Vos, N.; Thompson, A. D.; Callen, D. F.; Doggett, N.; Mole, S. E.; Dooley, T. P.; Barth, P. G.; Breuning, M. H.

1995-01-01

The gene that is involved in juvenile neuronal ceroid lipofuscinosis (JNCL), or Batten disease--CLN3--has been localized to 16p12, and the mutation shows a strong association with alleles of microsatellite markers D16S298, D16S299, and D16S288. Recently, haplotype analysis of a Batten patient from a

Proton angular distribution of {sup 16}O(d,p){sup 17}O{sup *} near a deuteron capture resonance; Evolution de la distribution angulaire des protons {sup 16}O(d,p){sup 17}O{sup *} au voisinage d'une resonance de capture du deuteron

Energy Technology Data Exchange (ETDEWEB)

Berthelot, R; Cohen, E; Cotton, H; Farraggi, T; Grjebine, A; Leveque, V; Naggiar, M; Roclawski-Conjeaud, D; Szteinsznaider, D [Commissariat a l' Energie Atomique, Saclay(France). Centre d' Etudes Nucleaires

1954-07-01

The study of angular distributions of the protons from the reaction {sup 16}O(d,p){sup 17}O{sup *} (level at 875 keV) was made, using a photographic method, at seven different deuteron energies, from 1.66 to 2.20 MeV (obtained with the Saclay electrostatic generator). The analysis of results shows that the angular distribution for forward angles is for each chosen energy in good agreement with the stripping theory (l = 0), even at the maximum of the capture resonance of the deuteron, about 2.1 MeV. Moreover, the differential cross section at 7 deg reaches a maximum for this resonance energy. (author) [French] L'etude des distributions angulaires des protons emis au cours de la reaction {sup 16}O(d,p){sup 17}O{sup *} (niveau a 875 key) a ete effectuee, par une methode photographique, pour 7 energies differentes de deuterons comprises entre 1,66 et 2,20 MeV (obtenues grace a l'accelerateur electrostatique de Saclay). L'analyse des resultats montre que la distribution angulaire vers l'avant est, pour toutes ces energies, en bon accord avec la theorie du ''stripping'' ( 1=0), meme au maximum de la resonance de capture du deuteron situee vers 2,1 MeV. De plus, la section efficace differentielle a 7 deg passe par un maximum pour cette energie de resonance. (auteur)

16-channel DWDM based on 1D defect mode nonlinear photonic crystal

Science.gov (United States)

Kalhan, Abhishek; Sharma, Sanjeev; Kumar, Arun

2018-05-01

We propose a sixteen-channel Dense Wavelength Division Multiplexer (DWDM), using the 1-D defect mode nonlinear photonic crystal which is a function of intensity as well as wavelength. Here, we consider an alternate layer of two semiconductor materials in which we found the bandgap of materials when defect layer is introduced then 16-channel dense wavelength division multiplexer is obtained within bandgap. From the theoretical analysis, we can achieve average quality factor of 7800.4, the uniform spectral line-width of 0.2 nm, crosstalk of -31.4 dB, central wavelength changes 0.07 nm/(1GW/cm2) and 100% transmission efficiency. Thus, Sixteen-channel DWDM has very high quality factor, low crosstalk, near 100% power transmission efficiency and small channel spacing (1.44 nm).

Suppression of HPV-16 late L1 5′-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs

Science.gov (United States)

Li, Xiaoze; Johansson, Cecilia; Glahder, Jacob; Mossberg, Ann-Kristin; Schwartz, Stefan

2013-01-01

Human papillomavirus type 16 (HPV-16) 5′-splice site SD3632 is used exclusively to produce late L1 mRNAs. We identified a 34-nt splicing inhibitory element located immediately upstream of HPV-16 late 5′-splice site SD3632. Two AUAGUA motifs located in these 34 nt inhibited SD3632. Two nucleotide substitutions in each of the HPV-16 specific AUAGUA motifs alleviated splicing inhibition and induced late L1 mRNA production from episomal forms of the HPV-16 genome in primary human keratinocytes. The AUAGUA motifs bind specifically not only to the heterogeneous nuclear RNP (hnRNP) D family of RNA-binding proteins including hnRNP D/AUF, hnRNP DL and hnRNP AB but also to hnRNP A2/B1. Knock-down of these proteins induced HPV-16 late L1 mRNA expression, and overexpression of hnRNP A2/B1, hnRNP AB, hnRNP DL and the two hnRNP D isoforms hnRNP D37 and hnRNP D40 further suppressed L1 mRNA expression. This inhibition may allow HPV-16 to hide from the immune system and establish long-term persistent infections with enhanced risk at progressing to cancer. There is an inverse correlation between expression of hnRNP D proteins and hnRNP A2/B1 and HPV-16 L1 production in the cervical epithelium, as well as in cervical cancer, supporting the conclusion that hnRNP D proteins and A2/B1 inhibit HPV-16 L1 mRNA production. PMID:24013563

16 CFR Appendix D to Part 436 - Sample Item 20(3) Table-Status of Franchise Outlets

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Sample Item 20(3) Table-Status of Franchise Outlets D Appendix D to Part 436 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES... Item 20(3) Table—Status of Franchise Outlets Status of Franchise Outlets For years 2004 to 2006 Column...

Effects of Formation Damage on Productivity of Underground Gas Storage Reservoirs

Directory of Open Access Journals (Sweden)

C.I.C. Anyadiegwu

2013-12-01

Full Text Available Analysis of the effects of formation damage on the productivity of gas storage reservoirs was performed with depleted oil reservoir (OB-02, located onshore, Niger Delta, Nigeria. Information on the reservoir and the fluids from OB-02 were collected and used to evaluate the deliverabilities of the gas storage reservoir over a 10-year period of operation. The results obtained were used to plot graphs of deliverability against permeability and skin respectively. The graphs revealed that as the permeability decreased, the skin increased, and hence a decrease in deliverability of gas from the reservoir during gas withdrawal. Over the ten years of operating the reservoir for gas storage, the deliverability and permeability which were initially 2.7 MMscf/d and 50 mD, with a skin of 0.2, changed to new values of 0.88 MMscf/d and 24 mD with the skin as 4.1 at the tenth year.

D1.3 -- Short Report on the First Draft Multi-link Channel Model

DEFF Research Database (Denmark)

Pedersen, Troels; Raulefs, Ronald; Steinboeck, Gerhard

This deliverable is a preliminary report on the activities towards multi-link channel models. It summarizes the activities and achievements of investigations of WP1 Task 1.2 in the first year of the project. In this deliverable work focuses on the characterization of the crosscorrelation of multi...

II Meeting of R and D in radioactive waste management, Madrid 14-16 June, 1995

International Nuclear Information System (INIS)

1995-01-01

The second meeting of R and D in radioactive waste management was organized by ENRESA on 14-16 June 1995 The main objective was to disseminate the most relevant works within the 2nd R and d plan, and to establish and adequate form involved for discussion R and D radioactive waste management. The meeting was articulated in 50 sessions: I.- Low and medium radioactive wastes. II.- High level radioactive wastes: activities of ENRESA III.- High level radioactive wastes: near field. IV.- Biosphere, radiological protection, behaviour evaluation. V.- Dismantling and decommissioning nuclear facilities VI.- Geosphere

D20S16 is a complex interspersed repeated sequence: Genetic and physical analysis of the locus

Energy Technology Data Exchange (ETDEWEB)

Bowden, D.W.; Krawchuk, M.D.; Howard, T.D. [Wake Forest Univ., Winston-Salem, NC (United States)] [and others

1995-01-20

The genomic structure of the D20S16 locus has been evaluated using genetic and physical methods. D20S16, originally detected with the probe CRI-L1214, is a highly informative, complex restriction fragment length polymorphism consisting of two separate allelic systems. The allelic systems have the characteristics of conventional VNTR polymorphisms and are separated by recombination ({theta} = 0.02, Z{sub max} = 74.82), as demonstrated in family studies. Most of these recombination events are meiotic crossovers and are maternal in origin, but two, including deletion of the locus in a cell line from a CEPH family member, occur without evidence for exchange of flanking markers. DNA sequence analysis suggests that the basis of the polymorphism is variable numbers of a 98-bp sequence tandemly repeated with 87 to 90% sequence similarity between repeats. The 98-bp repeat is a dimer of 49 bp sequence with 45 to 98% identity between the elements. In addition, nonpolymorphic genomic sequences adjacent to the polymorphic 98-bp repeat tracts are also repeated but are not polymorphic, i.e., show no individual to individual variation. Restriction enzyme mapping of cosmids containing the CRI-L1214 sequence suggests that there are multiple interspersed repeats of the CRI-L1214 sequence on chromosome 20. The results of dual-color fluorescence in situ hybridization experiments with interphase nuclei are also consistent with multiple repeats of an interspersed sequence on chromosome 20. 23 refs., 6 figs.

OSSMETER D3.4 – Language-Specific Source Code Quality Analysis

NARCIS (Netherlands)

J.J. Vinju (Jurgen); A. Shahi (Ashim); H.J.S. Basten (Bas)

2014-01-01

htmlabstractThis deliverable is part of WP3: Source Code Quality and Activity Analysis. It provides descriptions and prototypes of the tools that are needed for source code quality analysis in open source software projects. It builds upon the results of: • Deliverable 3.1 where infra-structure and

Transcriptome Profiling of Neovascularized Corneas Reveals miR-204 as a Multi-target Biotherapy Deliverable by rAAVs

Directory of Open Access Journals (Sweden)

Yi Lu

2018-03-01

Full Text Available Corneal neovascularization (NV is the major sight-threatening pathology caused by angiogenic stimuli. Current drugs that directly target pro-angiogenic factors to inhibit or reverse the disease require multiple rounds of administration and have limited efficacies. Here, we identify potential anti-angiogenic corneal microRNAs (miRNAs and demonstrate a framework that employs discovered miRNAs as biotherapies deliverable by recombinant adeno-associated viruses (rAAVs. By querying differentially expressed miRNAs in neovascularized mouse corneas induced by alkali burn, we have revealed 39 miRNAs that are predicted to target more than 5,500 differentially expressed corneal mRNAs. Among these, we selected miR-204 and assessed its efficacy and therapeutic benefit for treating injured corneas. Our results show that delivery of miR-204 by rAAV normalizes multiple novel target genes and biological pathways to attenuate vascularization of injured mouse cornea. Importantly, this gene therapy treatment alternative is efficacious and safe for mitigating corneal NV. Overall, our work demonstrates the discovery of potential therapeutic miRNAs in corneal disorders and their translation into viable treatment alternatives.

Allele frequencies data and statistic parameters for 16 STR loci—D19S433, D2S1338, CSF1PO, D16S539, D7S820, D21S11, D18S51, D13S317, D5S818, FGA, Penta E, TH01, vWA, D8S1179, TPOX, D3S1358—in the Rio de Janeiro population, Brazil

OpenAIRE

Góes, Andrea Carla de Souza; Silva, Dayse Aparecida da; Gil, Érica Helena Fonseca; Silva, Márcia Teixeira Desidério; Pereira, Rinaldo Wellerson; Carvalho, Elizeu Fagundes de

2004-01-01

Allele frequencies for 16 short tandem repeats (STR) loci were determined with a sample of 230–300 unrelated individuals from the population of Rio de Janeiro, Brazil. The loci are the most commonly used in forensic and paternity testing, being analysed by the Identifiler (Applied Biosystems) and PowerPlex 2.1 (Promega) commercial kits. It was proved that Penta E and D18S51 are the most polymorphic loci.

Draft Genome Sequence of the Plant Growth–Promoting Pseudomonas punonensis Strain D1-6 Isolated from the Desert Plant Erodium hirtum in Jordan

KAUST Repository

Lafi, Feras Fawzi

2017-01-13

Pseudomonas punonensis strain D1-6 was isolated from roots of the desert plant Erodium hirtum, near the Dead Sea in Jordan. The genome of strain D1-6 reveals several key plant growth-promoting and herbicide-resistance genes, indicating a possible specialized role for this endophyte.

Draft Genome Sequence of the Plant Growth–Promoting Pseudomonas punonensis Strain D1-6 Isolated from the Desert Plant Erodium hirtum in Jordan

KAUST Repository

Lafi, Feras Fawzi; AL Bladi, Maha Lafi Saleh; Salem, Nida M.; Al-Banna, Luma; Alam, Intikhab; Bajic, Vladimir B.; Hirt, Heribert; Saad, Maged

2017-01-01

Pseudomonas punonensis strain D1-6 was isolated from roots of the desert plant Erodium hirtum, near the Dead Sea in Jordan. The genome of strain D1-6 reveals several key plant growth-promoting and herbicide-resistance genes, indicating a possible specialized role for this endophyte.

D meson production and long-range azimuthal correlation in 8.16 TeV p+Pb collisions with ATLAS

CERN Document Server

Hu, Qipeng; The ATLAS collaboration

2018-01-01

Measurements of prompt charm mesons ($D^0$ and $D^*$) productions and azimuthal correlations between inclusive $D^*$ and charged particles are presented in p+Pb collisions data at 8.16 TeV collected in 2016 by ATLAS. No significant production asymmetry between forward and backward and asymmetry is observed. A finite $2\\cos(2\\Delta\\phi)$ modulation for inclusive $D^*$ is observed with a $1\\sim2\\sigma$ significance, depending on multiplicity, broadly consistent with what have been observed for light hadrons and HF muons.

Urban strategies for Waste Management in Tourist Cities. D2.7 : Compendium of waste management practices in pilot cities and best practices in touristic cities

NARCIS (Netherlands)

Gruber, Iris; Mayerhofer, Johannes; Obersteiner, Gudrun; Ramusch, Roland; Romein, A.; Eriksson, Mattias; Grosse, Juliane; MC. Nascimento, Gisela; Bjorn Olsen, Trine; de Luca, Claudia; Zapata Aranda, Pilar; Kazeroni, Marie; Kovacs, Ernest

2017-01-01

This report (Deliverable D2.7) refers to URBANWASTE Work Package 2, Task 2.8. Under this Task the current waste prevention and management practices in the URBANWASTE pilot cases are investigated and best practices coming from the EU context (focussing on touristic processes) are identified. This

Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules.

Science.gov (United States)

Pulipparacharuvil, Suprabha; Akbar, Mohammed Ali; Ray, Sanchali; Sevrioukov, Evgueny A; Haberman, Adam S; Rohrer, Jack; Krämer, Helmut

2005-08-15

Mutations that disrupt trafficking to lysosomes and lysosome-related organelles cause multiple diseases, including Hermansky-Pudlak syndrome. The Drosophila eye is a model system for analyzing such mutations. The eye-color genes carnation and deep orange encode two subunits of the Vps-C protein complex required for endosomal trafficking and pigment-granule biogenesis. Here we demonstrate that dVps16A (CG8454) encodes another Vps-C subunit. Biochemical experiments revealed a specific interaction between the dVps16A C-terminus and the Sec1/Munc18 homolog Carnation but not its closest homolog, dVps33B. Instead, dVps33B interacted with a related protein, dVps16B (CG18112). Deep orange bound both Vps16 homologs. Like a deep orange null mutation, eye-specific RNAi-induced knockdown of dVps16A inhibited lysosomal delivery of internalized ligands and interfered with biogenesis of pigment granules. Ubiquitous knockdown of dVps16A was lethal. Together, these findings demonstrate that Drosophila Vps16A is essential for lysosomal trafficking. Furthermore, metazoans have two types of Vps-C complexes with non-redundant functions.

Surfactant protein D, Club cell protein 16, Pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease

DEFF Research Database (Denmark)

Johansson, Sofie Lock; Vestbo, J.; Sorensen, G. L.

2014-01-01

for the assessment of patients, prediction of risk, and guidance of treatment. The aim of this review is to provide a comprehensive summary of observations for a selection of recently investigated pulmonary inflammatory biomarkers (Surfactant protein D (SP-D), Club cell protein 16 (CC-16), and Pulmonary...

Resonance states in 16O +16O, 12C +16O, α +16O and α +12C

Indian Academy of Sciences (India)

Thus starting with two well-separated nuclei in their ground state, ... n = 1, 2. (3) and V0 > 0 with the eight parameters V0, ξ1, ξ2, Rm, d1, d2, VI and aI. This .... in the range L = 4 to 16 are observed within about 30 MeV of excitation. The. 0. 20. 40. 60. 80 .... The characteristics of the potentials show a systematic trend having.

Data needs and computational requirements for asset management decision making. Internal deliverable ID5.2.1

DEFF Research Database (Denmark)

Catrinu-Renstrom, Maria; Clement, Rémy; Tournebise, Pascal

addressing to the requirements of RMAC criterion developed in work package 2. The report has been written by several partners, three of them being European TSOs, and the three other being academic partners. Special attention has been paid to address every topic in asset management decision making process......The objective of this deliverable is to present the requirements for adapting available tools/models and identifying data needs for reliability analysis and optimal decision-making for asset management decision making process. It will serve as a basis for the next tasks of GARPUR work package 5...... decision making process, as described in work package 2. Some advanced models exist in scientific literature to characterize the spatio-temporal variation and correlations of relevant factors. Some of these models have been proposed in academia, and offer improved representation with respect to those...

Bioclim Deliverable D1: environmental change analysis

International Nuclear Information System (INIS)

2001-01-01

The BIOCLIM project on modelling sequential Biosphere systems under Climate change for radioactive waste disposal is part of the EURATOM fifth European framework programme. The project was launched in October 2000 for a three-year period. The project aims at providing a scientific basis and practical methodology for assessing the possible long term impacts on the safety of radioactive waste repositories in deep formations due to climate and environmental change. The project brings together a number of representatives from both European radioactive waste management organisations which have national responsibilities for the safe disposal of radioactive waste, either as disposers or regulators, and several highly experienced climate research teams. In particular, BIOCLIM aims to address the important objective of how to represent the development of future biosphere systems by addressing both how to model long-term climate change, the relevant environmental consequences of such changes and the implementation of a sequential approach to such changes. The results from the development of this sophisticated approach will be of great benefit for improving long term radiological impact calculations and the information presented in a safety case. Simulations will be conducted to represent the time series of long-term climate in three European areas within which disposal sites may be established (i.e. Central/Southern Spain, Northeast of France and Central Britain). Two complementary strategies will provide representations of future climate predictions together with associated vegetation patterns using either an analysis of distinct climate states or a continuous climate simulation over at least one glacial-interglacial cycle and possibly for other selected periods over the next 1,000,000 years. These results will be used to derive the characteristics of possible future human environments (i.e. biosphere systems) through which radionuclides, emerging from the repository, may

Designing equitable workplace dietary interventions: perceptions of intervention deliverers.

Science.gov (United States)

Smith, Sarah A; Visram, Shelina; O'Malley, Claire; Summerbell, Carolyn; Araujo-Soares, Vera; Hillier-Brown, Frances; Lake, Amelia A

2017-10-16

Workplaces are a good setting for interventions that aim to support workers in achieving a healthier diet and body weight. However, little is known about the factors that impact on the feasibility and implementation of these interventions, and how these might vary by type of workplace and type of worker. The aim of this study was to explore the views of those involved in commissioning and delivering the Better Health at Work Award, an established and evidence-based workplace health improvement programme. One-to-one semi-structured interviews were conducted with 11 individuals in North East England who had some level of responsibility for delivering workplace dietary interventions. Interviews were transcribed verbatim and analysed using thematic framework analysis. A number of factors were felt to promote the feasibility and implementation of interventions. These included interventions that were cost-neutral (to employee and employer), unstructured, involved colleagues for support, took place at lunchtimes, and were well-advertised and communicated via a variety of media. Offering incentives, not necessarily monetary, was perceived to increase recruitment rates. Factors that militate against feasibility and implementation of interventions included worksites that were large in size and remote, working patterns including shifts and working outside of normal working hours that were not conducive to workers being able to access intervention sessions, workplaces without appropriate provision for healthy food on site, and a lack of support from management. Intervention deliverers perceived that workplace dietary interventions should be equally and easily accessible (in terms of cost and timing of sessions) for all staff, regardless of their job role. Additional effort should be taken to ensure those staff working outside normal working hours, and those working off-site, can easily engage with any intervention, to avoid the risk of intervention-generated inequalities (IGIs).

Silver deposited carboxymethyl chitosan-grafted magnetic nanoparticles as dual action deliverable antimicrobial materials.

Science.gov (United States)

Vo, Duc-Thang; Sabrina, Sabrina; Lee, Cheng-Kang

2017-04-01

Carboxymethyl chitosan (CMCS) was known to have a much better antimicrobial activity than chitosan due to the increased cationic -NH 3 + groups resulted from the intra- and intermolecular interactions between the carboxyl and amino groups. CMCS was grafted onto the surface of silica coated magnetic nanoparticles (MNPs) to obtain magnetically retrievable and deliverable antimicrobial nanoparticles (MNPs@CMCS). The presence of carboxylate groups in CMCS not only enhanced antimicrobial activity but also enabled Ag ions chelating ability to induce the in situ formation of Ag nanoparticles (AgNPs). The deposition of AgNPs on the surface of MNPs@CMCS could significantly increase its antimicrobial activity against planktonic cells due to the dual action of CMCS and AgNPs. Due to its high magnetism, the as-prepared MNPs@CMCS-Ag could be efficiently delivered into an existing biofilm under the guidance of an applied magnetic field. Without direct contact, the Ag ions and/or radical oxygen species (ROS) released from the deposited Ag nanoparticles could effectively kill the bacteria embedded in the extracellular polymeric substances (EPS) matrix of biofilm. Copyright © 2016 Elsevier B.V. All rights reserved.

HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner.

Science.gov (United States)

Rabachini, Tatiana; Boccardo, Enrique; Andrade, Rubiana; Perez, Katia Regina; Nonogaki, Suely; Cuccovia, Iolanda Midea; Villa, Luisa Lina

2018-04-27

Human Papillomavirus (HPV) infection is the main risk factor for the development and progression of cervical cancer. HPV-16 E6 and E7 expression is essential for induction and maintenance of the transformed phenotype. These oncoproteins interfere with the function of several intracellular proteins, including those controlling the PI3K/AKT/mTOR pathway in which Phospolipase D (PLD) and Phosphatidic acid (PA) play a critical role. PLD activity was measured in primary human keratinocytes transduced with retroviruses expressing HPV-16 E6, E7 or E7 mutants. The cytostatic effect of rapamycin, a well-known mTOR inhibitor with potential clinical applications, was evaluated in monolayer and organotypic cultures. HPV-16 E7 expression in primary human keratinocytes leads to an increase in PLD expression and activity. Moreover, this activation is dependent on the ability of HPV-16 E7 to induce retinoblastoma protein (pRb) degradation. We also show that cells expressing HPV-16 E7 or silenced for pRb acquire resistance to the antiproliferative effect of rapamycin. This is the first indication that HPV oncoproteins can affect PLD activity. Since PA can interfere with the ability of rapamycin to bind mTOR, the use of combined strategies to target mTOR and PLD activity might be considered to treat HPV-related malignancies.

D2.1 - An EA Active, Problem Based Learning Methodology - EAtrain2

DEFF Research Database (Denmark)

Ryberg, Thomas; Georgsen, Marianne; Buus, Lillian

This deliverable reports on the work undertaken in work package 2 with the key objective to develop a learning methodology for web 2.0 mediated Enterprise Architecture (EA) learning building on a problem based learning (PBL) approach. The deliverable reports not only on the methodology but also...... on the activities leading to its development (literature review, workshops, etc.) and on further outcomes of this work relevant to the platform specification and pilot courses preparation....

TH-C-12A-06: Feasibility of a MLC-Based Inversely Optimized Multi-Field Grid Therapy Technique

Energy Technology Data Exchange (ETDEWEB)

Jin, J [Georgia Regents University, Augusta, GA (Georgia); Zhao, B; Huang, Y; Kim, J; Qin, Y; Wen, N; Ryu, S; Chetty, I [Henry Ford Health System, Detroit, MI (United States)

2014-06-15

Purpose: Grid therapy (GT), which generates highly spatially modulated dose distributions, can deliver single- or hypo-fractionated radiotherapy for large tumors without causing significant toxicities. GT may be applied in combination with immunotherapy, in light of recent preclinical data of synergetic interaction between radiotherapy and immunotherapy. However, conventional GT uses only one field, which does not have the advantage of multi-fields in 3D conformal-RT or IMRT. We have proposed a novel MLC-based, inverse-planned multi-field 3D GT technique. This study aims to test its deliverability and dosimetric accuracy. Methods: A lattice of small spheres was created as the boost volume within a large target. A simultaneous boost IMRT plan with 8-Gy to the target and 20-Gy to the boost volume was generated in the Eclipse treatment planning system (AAA v10) with a HD120 MLC. Nine beams were used, and the gantry and couch angles were selected so that the spheres were perfectly aligned in every beams eye view. The plan was mapped to a phantom with dose scaled. EBT3 films were calibrated and used to measure the delivered dose. Results: The IMRT plan generated a highly spatially modulated dose distribution in the target. D95%, D50%, D5% for the spheres and the targets in Gy were 18.5, 20.0, 21.4 and 7.9, 9.8, 16.1, respectively. D50% for a 1cm ring 1cm outside the target was 2.9-Gy. Film dosimetry showed good agreement between calculated and delivered dose, with an overall gamma passing rate of 99.6% (3%/1mm). The point dose differences for different spheres varied from 1–6%. Conclusion: We have demonstrated the deliverability and dose calculation accuracy of the MLC-based inversely optimized multi-field GT technique, which achieved a brachytherapy-like dose distribution. Single-fraction high dose can be delivered to the spheres in a large target with minimal dose to the surrounding normal tissue.

C2 Domain Ontology within Our Lifetime

Science.gov (United States)

2009-06-01

25] Masolo, C., et al: The WonderWeb Library of Foundational Ontologies Prelimary Report, WonderWeb Deliverable D17, ISTC -CNR, May 2003. [26...www.ifomis.org/bfo/BFO  [25] Masolo, C., et al: The WonderWeb Library of Foundational Ontologies Prelimary Report, WonderWeb Deliverable D17, ISTC -CNR

Training industry needs & Technology Industry needs

NARCIS (Netherlands)

Klemke, Roland; Kuula, Timo; Helin, Kaj; Wild, Fridolin

2017-01-01

This deliverable joins D1.1 (User Industry Needs) and D1.2 (Technology Industry Needs and Affordances) and reports on the outcomes of Tasks T1.1 (Training Industry Assessment) and T1.2 (Technology Industry Assessment). We merged the deliverables for the following reasons: For readability ease we

idSpace D2.3 – Semantic meta-model integration and transformations v2

DEFF Research Database (Denmark)

Dolog, Peter; Grube, Pascal; Schmid, Klaus

2009-01-01

This deliverable discusses an extended set of requirements for transformations and metamodel for creativity techniques. Based on the requirements, the deliverable provides refined meta-model. The metamodel allows for more advanced transforma-tion concepts besides the previously delivered graph tr...... oriented implemen-tation with portlets and widgets in the Liferay portal....

Factors affecting seasonal gas prices: Analysis of trends and R and D implications. Final report, November 1990-February 1992

International Nuclear Information System (INIS)

Denhardt, R.C.

1992-02-01

Three economic factors were identified which influence the seasonality of gas prices: fuel switching, storage, and utilization of wellhead deliverability. Also, contract structures will have an influence on the seasonality of natural gas prices. Increases in the utilization of wellhead deliverability tends to increase the seasonality of gas prices. Price-induced fuel switching capability is too small to significantly influence the seasonality of gas prices. If there is adequate deliverability, the cost of interruptible storage, including carry cost, will place a ceiling on the seasonability of gas prices. This cost is about $.70 per MMBtu. If deliverability tightens, then the cost of firm storage or producer shut-ins will place a ceiling on gas prices. The ceiling would range from $1.00 to $1.20 per MMBtu. There is concern about whether the current market structure will provide for a smooth return to full cycle pricing. The current premiums for new contracts are inadequate to achieve this objective

16 CFR 1018.16 - Membership selection.

Science.gov (United States)

2010-01-01

....16 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT... volunteer, that bear any relationship to the subject area of product safety or to membership on the advisory... qualified, staff members of the Commission, including the Advisory Committee Management Officer. (d) The...

D5.3 Reading reliability report

DEFF Research Database (Denmark)

Cetin, Bilge Kartal; Galiotto, Carlo; Cetin, Kamil

2010-01-01

This deliverable presents a detailed description of the main causes of reading reliability degradation. Two main groups of impairments are recognized: those at the physical layer (e.g., fading, multipath, electromagnetic interference, shadowing due to obstacles, tag orientation misalignment, tag...... bending, metallic environments, etc.) and those at the medium access control sub-layer (e.g., collisions due to tag-to-tag, reader-to-reader and multiple readers-to-tag interference). The review presented in this deliverable covers previous reliability reports and existing definitions of RFID reading...... reliability. Performance metrics and methodologies for assessing reading reliability are further discussed. This document also presents a review of state-of-the-art RFID reading reliability improvement schemes. The solutions are classified into physical- (PHY), medium access control- (MAC), upper-, and cross...

Virtual Campus Hub technology

DEFF Research Database (Denmark)

Vercoulen, Frank; Badger, Merete; Monaco, Lucio

This deliverable briefly describes which technological components have been delivered for the Virtual Campus Hub and how they can be used. A detailed discussion of the technical details of the components, how they were realized and how they fit the VCH concept can be found in deliverables D5.......4. Virtual Campus Hub Technology Evaluation Report and D6.7 The Virtual Campus Hub Concept....

16,17-Seco- and 2,3:16,17-di-seco-pregnanes from Guarea guidonia

Energy Technology Data Exchange (ETDEWEB)

Garcez, Walmir Silvan; Garcez, Fernanda Rodrigues [Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS (Brazil). Dept. de Quimica]. E-mail: wgarcez@nin.ufms.br; Soares, Luzinatia Ramos [Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS (Brazil). Dept. de Quimica; Universidade Estadual de Mato Grosso do Sul, Campo Grande, MS (Brazil)

2008-07-01

Two new seco- and di-seco-pregnanes, 2{alpha},3{beta}-dihydroxy-16,17-seco-pregn-17-ene-16-oic acid methyl ester 2{beta},19-hemiketal (1) and 2,3:16,17-di-seco-pregn-17-ene-3-oic acid-16-oic acid methyl ester-19-hydroxy-2-carboxylic acid-2,19-lactone (2), have been obtained from the trunk bark of Guarea guidonia. Their structures have been established by a combination of 1D- and 2D-NMR spectroscopic techniques and MS data. The unique seco- and di-seco-pregnane carbocyclic skeletal types as found in compounds 1 and 2 are being reported in the Meliaceae for the first time as well as the occurrence of pregnanes in the genus Guarea. (author)

Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan.

Science.gov (United States)

Bansal, Ankita; Kwon, Eun-Soo; Conte, Darryl; Liu, Haibo; Gilchrist, Michael J; MacNeil, Lesley T; Tissenbaum, Heidi A

2014-01-01

Insulin/IGF-1 signaling plays a central role in longevity across phylogeny. In C. elegans, the forkhead box O (FOXO) transcription factor, DAF-16, is the primary target of insulin/IGF-1 signaling, and multiple isoforms of DAF-16 (a, b, and d/f) modulate lifespan, metabolism, dauer formation, and stress resistance. Thus far, across phylogeny modulation of mammalian FOXOs and DAF-16 have focused on post-translational regulation with little focus on transcriptional regulation. In C. elegans, we have previously shown that DAF-16d/f cooperates with DAF-16a to promote longevity. In this study, we generated transgenic strains expressing near-endogenous levels of either daf-16a or daf-16d/f, and examined temporal expression of the isoforms to further define how these isoforms contribute to lifespan regulation. Here, we show that DAF-16a is sensitive both to changes in gene dosage and to alterations in the level of insulin/IGF-1 signaling. Interestingly, we find that as worms age, the intestinal expression of daf-16d/f but not daf-16a is dramatically upregulated at the level of transcription. Preventing this transcriptional upregulation shortens lifespan, indicating that transcriptional regulation of daf-16d/f promotes longevity. In an RNAi screen of transcriptional regulators, we identify elt-2 (GATA transcription factor) and swsn-1 (core subunit of SWI/SNF complex) as key modulators of daf-16d/f gene expression. ELT-2 and another GATA factor, ELT-4, promote longevity via both DAF-16a and DAF-16d/f while the components of SWI/SNF complex promote longevity specifically via DAF-16d/f. Our findings indicate that transcriptional control of C. elegans FOXO/daf-16 is an essential regulatory event. Considering the conservation of FOXO across species, our findings identify a new layer of FOXO regulation as a potential determinant of mammalian longevity and age-related diseases such as cancer and diabetes.

Deliverable 6.2 - Software: upgraded MC simulation tools capable of simulating a complete in-beam ET experiment, from the beam to the detected events. Report with the description of one (or few) reference clinical case(s), including the complete patient model and beam characteristics

CERN Document Server

The ENVISION Collaboration

2014-01-01

Deliverable 6.2 - Software: upgraded MC simulation tools capable of simulating a complete in-beam ET experiment, from the beam to the detected events. Report with the description of one (or few) reference clinical case(s), including the complete patient model and beam characteristics

D meson production and long-range azimuthal correlation in 8.16 TeV p+Pb collisions with ATLAS

CERN Document Server

Hu, Qipeng; The ATLAS collaboration

2017-01-01

Measurements of production of prompt charm mesons (D0 and D*) and azimuthal correlations between inclusive D* and charged particles are presented in p+Pb collisions data at 8.16 TeV collected in 2016 by ATLAS. The prompt charm meson production is measured in minimum bias p+Pb data, reconstructed via two decay channels: D0->K+pi and D*->D0+pi->K+pi+pi. The production asymmetry between forward and backward center-of-mass rapidities for the charm mesons is studied for the range of |y*| < 0.5, and no significant asymmetry is observed. In the D*-hadron correlations, the pT of identified D* is more closely related to the pt of primordial heavy quarks, relative to the measurement of their decay muons. A finite elliptic harmonic coefficient for inclusive D* and charge particles have been extracted with a significance of one to two standard deviations, depending on multiplicity, broadly consistent with what have been observed for light hadrons and muons from heavy quark decaying.

Sampling and Analysis Plan (SAP) for Assessment of LANL-Derived Residual Radionuclides in Soils within Tract A-16-d for Land Conveyance and Transfer

Energy Technology Data Exchange (ETDEWEB)

Gillis, Jessica Mcdonnel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2016-02-18

The A-16-D tract consists of the easternmost portion of DP mesa and is bounded on the North by the canyon bottom of DP canyon and on the South by the edge of the initial slope into Los Alamos Canyon (see Figure 1).

Unexpected Diagnosis of Cerebral Toxoplasmosis by 16S and D2 Large-Subunit Ribosomal DNA PCR and Sequencing

DEFF Research Database (Denmark)

Kruse, Alexandra Yasmin Collin; Kvich, Lasse Andersson; Eickhardt-Dalbøge, Steffen Robert

2015-01-01

The protozoan parasite Toxoplasma gondii causes severe opportunistic infections. Here, we report an unexpected diagnosis of cerebral toxoplasmosis. T. gondii was diagnosed by 16S and D2 large-subunit (LSU) ribosomal DNA (rDNA) sequencing of a cerebral biopsy specimen and confirmed by T. gondii...

An editorial approach: Mike Nelson’s corridors and The Deliverance and The Patience

Directory of Open Access Journals (Sweden)

Helen Hughes

2015-06-01

Full Text Available This essay contrasts the contemporary British artist Mike Nelson’s approach to constructing his large, multi-room installations with his approach to editing the numerous artist books that he has produced since 2000. This comparison reveals several compositional symmetries between the two, namely pertaining to narrative non-linearity and meta-fictionality. The logic of montage is shown to similarly underscore both the books and the installations. This essay argues that the corridors connecting the different rooms of Nelson’s installations function in a similar way to the logic of montage: they play an integral role as the support that binds the structure of the installation (its multiple rooms together as a whole. This essay argues that the corridor is the primary viewing framework of the installation for the viewer, and that this vantage point is significant because the necessarily partial vision of the installation from the space of the corridor demonstrates the logic of installation art more broadly. I conclude by mapping the key compositional elements of Nelson’s artist books onto his installations, taking the 2001 work The Deliverance and The Patience as a case study, to show that the books do not exemplify the artwork as with traditional exhibition catalogues, but rather parallel it. That is, a structural continuity is established between these two facets of his work.

Rethinking the Business Model in Construction by the Use of Off-Site System Deliverance: Case of the Shaft Project

DEFF Research Database (Denmark)

Thuesen, Christian; Hvam, Lars

2013-01-01

This paper presents a set of insights to be used in the development of business models for off-site system deliveries contributing to the development of Off-Site Manufacturing practices (OSM). The theoretical offset for discussing the development of business models is the blue ocean strategy...... of installation shafts. Findings from the development and production of the installation shaft show that system deliveries represent a promising strategy for moving from red ocean competitive environment with the predominant cost+ business model, to a blue ocean situation in which the competition emerges...... in the constant pursue of value creation and cost reduction. On the basis of that system deliverances represent a promising strategy in the future development and application of off-site manufacturing practices. The application of system deliveries is however demanding as it represents a fundamental shift...

Population database on: D1S1656, D2S441, D2S1338, D3S1358, D8S1179, D10S1248, D22S1045, D12S391, D16S539, D18S51, D19S433, D21S11, FGA, TH01, vWA loci included in NGM system based on one thousand unrelated individuals from Lodz region of Central Poland

Directory of Open Access Journals (Sweden)

Renata Jacewicz

2017-01-01

Full Text Available A population data obtained on the basis of sample of 1000 unrelated individuals of Polish ancestry living in Lodz region of Central Poland with use of fluorescent multiplex-PCR and capillary electrophoresis were presented. Evaluation included 15 polymorphic loci DNA – STR from NGM multiplex-PCR set, ie. D1S1656, D2S441, D2S1338, D3S1358, D8S1179, D10S1248, D12S391, D16S539, D18S51, D19S433, D21S11, D22S1045, FGA, TH01, vWA. The allele frequency distribution and crucial statistical parameters for the investigated markers and the whole set were calculated. The compliance of the studied population with Hardy-Weinberg equilibrium, independence of inheritance and high parameters of the usefulness in forensic genetics have been demonstrated. The interpopulation comparison performed by the „neighbor-joining” method as well as multidimensional scaling depicted the genetic distances dividing the examined Polish population from other populations of Poland, Europe and the world.

Intermediate Technical Review Report : Deliverable D0.4

DEFF Research Database (Denmark)

Bygholm, Ann; Buus, Lillian; Svendsen, Brian Møller

This report provides a coprehensivi overview of the activities of the Mediterranean Virtual Univeristy Project from the contract start for December 2005. It provides a review of the achievements so far and a discussion of issues currently being adressed along with remedial actions. The report also...

Intermediate Technical Review Report : Deliverable D0.4

DEFF Research Database (Denmark)

Bygholm, Ann; Buus, Lillian; Svendsen, Brian Møller

This report provides a coprehensivi overview of the activities of the Mediterranean Virtual Univeristy Project from the contract start for December 2005. It provides a review of the achievements so far and a discussion of issues currently being adressed along with remedial actions. The report als...

Impact of 9p deletion and p16, Cyclin D1, and Myc hyperexpression on the outcome of anaplastic oligodendrogliomas.

Directory of Open Access Journals (Sweden)

Karine Michaud

Full Text Available To study the presence of 9p deletion and p16, cyclin D1 and Myc expression and their respective diagnostic and prognostic interest in oligodendrogliomas.We analyzed a retrospective series of 40 consecutive anaplastic oligodendrogliomas (OIII from a single institution and compared them to a control series of 10 low grade oligodendrogliomas (OII. Automated FISH analysis of chromosome 9p status and immunohistochemistry for p16, cyclin D1 and Myc was performed for all cases and correlated with clinical and histological data, event free survival (EFS and overall survival (OS.Chromosome 9p deletion was observed in 55% of OIII (22/40 but not in OII. Deletion was highly correlated to EFS (median = 29 versus 53 months, p<0.0001 and OS (median = 48 versus 83 months, p<0.0001 in both the total cohort and the OIII population. In 9p non-deleted oligodendrogliomas, p16 hyperexpression correlated with a shorter OS (p = 0.02 in OII and p = 0.0001 in OIII whereas lack of p16 expression was correlated to a shorter EFS and OS in 9p deleted OIII (p = 0.001 and p = 0.0002 respectively. Expression of Cyclin D1 was significantly higher in OIII (median expression 45% versus 14% for OII, p = 0.0006 and was correlated with MIB-1 expression (p<0.0001, vascular proliferation (p = 0.002, tumor necrosis (p = 0.04 and a shorter EFS in the total cohort (p = 0.05. Hyperexpression of Myc was correlated to grade (median expression 27% in OII versus 35% in OIII, p = 0.03, and to a shorter EFS in 9p non-deleted OIII (p = 0.01.Chromosome 9p deletion identifies a subset of OIII with significantly worse prognosis. The combination of 9p status and p16 expression level identifies two distinct OIII populations with divergent prognosis. Hyperexpression of Bcl1 and Myc appears highly linked to anaplasia but the prognostic value is unclear and should be investigated further.

$D$ meson production and long-range azimuthal correlation in $8.16~\\mathrm{TeV}$ $p$+Pb collisions with ATLAS

CERN Document Server

The ATLAS collaboration

2017-01-01

The production of $D^{0}(\\overline{D^0})$ and $D^{*\\pm}$ mesons has been measured with the ATLAS detector in $p$+Pb collisions at $\\sqrt{s_{_\\mathrm{NN}}}=8.16~\\mathrm{TeV}$ with an integrated luminosity of $76.3\\mu b^{-1}$ taken in 2016. The $D$ meson production asymmetry between forward ($0 < y^* < 0.5$) and backward ($-0.5 < y^* < 0$) center-of-mass rapidities is studied, and no significant asymmetry is observed. Azimuthal correlations between inclusive $D^{*\\pm}$ and charged particles are also presented in intervals of event-wise charged-particle multiplicity. The second-order harmonic coefficients for inclusive $D^{*\\pm}$ and charged particles azimuthal correlation have been extracted using template fits.

D3.2: SPEED-5G enhanced functional and system architecture, scenarios and performance evaluation metrics

OpenAIRE

Mumtaz, Shahid; Saidul, Kazi; Rodriguez, Huq Jonathan; Marques, Paulo; Radwan, Ayman; BT, Keith Briggs Michael Fitch; Georgakopoulos, Andreas; Belikaidis, Ioannis-Prodromos; Vlacheas, Panagiotis; Kelaidonis, Dimitrios; Kosmatos, Evangelos; Kotrotsos, Serafim; Vassaki, Stavroula; Kritikou, Yiouli; Demestichas, Panagiotis

2017-01-01

This deliverable contains a detailed description of the use cases considered in SPEED-5G, which will be used as a basis for demonstration in project. These use cases are Dynamic Channel selection, Load balancing, carrier aggregation. This deliverable also explains the SPEED-5G architecture design principles, which is based on software-defined networking and network function virtualisation. The degree of virtualisation is further illustrated by a number of novel contributions from involved par...

16O resonances near 4α threshold through 12C (6Li,d ) reaction

Science.gov (United States)

Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Horodynski-Matsushigue, L. B.; Duarte, J. L. M.; Rodrigues, C. L.; de Faria, P. Neto; Cunsolo, A.; Cappuzzello, F.; Foti, A.; Agodi, C.; Cavallaro, M.; di Napoli, M.; Ukita, G. M.

2014-11-01

Several narrow alpha resonant 16O states were detected through the 12C (6Li,d ) reaction, in the range of 13.5 to 17.5 MeV of excitation energy. The reaction was measured at a bombarding energy of 25.5 MeV employing the São Paulo Pelletron-Enge-Spectrograph facility and the nuclear emulsion technique. Experimental angular distributions associated with natural parity quasi-bound states around the 4α threshold are presented and compared to DWBA predictions. The upper limit for the resonance widths obtained is near the energy resolution (15 keV).

16O resonances near 4α threshold through 12C(6Li,d) reaction

International Nuclear Information System (INIS)

Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Horodynski-Matsushigue, L. B.; Duarte, J. L. M.; Rodrigues, C. L.; Faria, P. Neto de; Cunsolo, A.; Cappuzzello, F.; Foti, A.; Agodi, C.; Cavallaro, M.; Napoli, M. di; Ukita, G. M.

2014-01-01

Several narrow alpha resonant 16 O states were detected through the 12 C( 6 Li,d) reaction, in the range of 13.5 to 17.5 MeV of excitation energy. The reaction was measured at a bombarding energy of 25.5 MeV employing the São Paulo Pelletron-Enge-Spectrograph facility and the nuclear emulsion technique. Experimental angular distributions associated with natural parity quasi-bound states around the 4α threshold are presented and compared to DWBA predictions. The upper limit for the resonance widths obtained is near the energy resolution (15 keV)

SU-F-BRB-12: A Novel Haar Wavelet Based Approach to Deliver Non-Coplanar Intensity Modulated Radiotherapy Using Sparse Orthogonal Collimators

Energy Technology Data Exchange (ETDEWEB)

Nguyen, D; Ruan, D; Low, D; Sheng, K [Deparment of Radiation Oncology, University of California Los Angeles, Los Angeles, CA (United States); O’Connor, D [Deparment of Mathematics, University of California Los Angeles, Los Angeles, CA (United States); Boucher, S [RadiaBeam Technologies, Santa Monica, CA (United States)

2015-06-15

Purpose: Existing efforts to replace complex multileaf collimator (MLC) by simple jaws for intensity modulated radiation therapy (IMRT) resulted in unacceptable compromise in plan quality and delivery efficiency. We introduce a novel fluence map segmentation method based on compressed sensing for plan delivery using a simplified sparse orthogonal collimator (SOC) on the 4π non-coplanar radiotherapy platform. Methods: 4π plans with varying prescription doses were first created by automatically selecting and optimizing 20 non-coplanar beams for 2 GBM, 2 head & neck, and 2 lung patients. To create deliverable 4π plans using SOC, which are two pairs of orthogonal collimators with 1 to 4 leaves in each collimator bank, a Haar Fluence Optimization (HFO) method was used to regulate the number of Haar wavelet coefficients while maximizing the dose fidelity to the ideal prescription. The plans were directly stratified utilizing the optimized Haar wavelet rectangular basis. A matching number of deliverable segments were stratified for the MLC-based plans. Results: Compared to the MLC-based 4π plans, the SOC-based 4π plans increased the average PTV dose homogeneity from 0.811 to 0.913. PTV D98 and D99 were improved by 3.53% and 5.60% of the corresponding prescription doses. The average mean and maximal OAR doses slightly increased by 0.57% and 2.57% of the prescription doses. The average number of segments ranged between 5 and 30 per beam. The collimator travel time to create the segments decreased with increasing leaf numbers in the SOC. The two and four leaf designs were 1.71 and 1.93 times more efficient, on average, than the single leaf design. Conclusion: The innovative dose domain optimization based on compressed sensing enables uncompromised 4π non-coplanar IMRT dose delivery using simple rectangular segments that are deliverable using a sparse orthogonal collimator, which only requires 8 to 16 leaves yet is unlimited in modulation resolution. This work is

VP-16 and alkylating agents activate a common metabolic pathway for suppression of DNA replication

International Nuclear Information System (INIS)

Das, S.K.; Berger, N.A.

1986-01-01

The cytotoxic effects of etoposide (VP-16) are mediated by topoisomerase II production of protein crosslinked DNA strand breaks. Previous studies have shown that alkylating agent induced DNA damage results in expansion of dTTP pools and reduction of dCTP pools and DNA replication. Studies were conducted with V79 cells to determine whether the metabolic consequences of VP-16 treatment were similar to those induced by alkylating agents. Treatment with 0.5μM VP-16 prolonged the doubling time of V79 cells from 12 to 18 hrs and caused cell volume to increase from 1.1 to 1.6 x 10 -12 l. 2mM caffeine completely blocked the volume increase and substantially prevented the prolongation of doubling time. 5μM VP-16 reduced the rate of [ 3 H]TdR incorporation by 70%, whereas in the presence of 2mM caffeine, VP-16 caused only a 10% decrease in the rate of [ 3 H]TdR incorporation. 4 hr treatment with 5.0μM VP-16 increased dTTP levels from 65 +/- 10 pmol/10 6 cells to 80 +/- 13 pmol/10 6 cells and caused dCTP level to decline from 113 +/- 23 pmol/10 6 cells to 92 +/- 17 pmol/10 6 cells. These results indicate that the metabolic consequences of VP-16 treatment are similar to alkylating agent treatment and that an increase in dTTP pools with a subsequent effect on ribonucleotide reductase may be a final common pathway by which many cytotoxic agents suppress DNA synthesis

Molecular And 3D-Structural Characterization Of Fructose-1,6-Bisphosphate Aldolase Derived From Metroxylon Sagu

Directory of Open Access Journals (Sweden)

Hairul Azman Roslan

2017-06-01

Full Text Available ABSTRACT Fructose-1,6-bisphosphate aldolase (FBAld is an enzyme that catalyzes the cleavage of D-fructose-1,6-phosphate (FBP to D-glyceraldehyde-3-phosphate (G3P and dihydroxyacetone phosphate (DHAP, and plays vital role in glycolysis and gluconeogenesis. However, molecular characterization and functional roles of FBAld remain unknown in sago palm. Here we report a modified CTAB-RNA extraction method was developed for the isolation of good quality RNA (RIN>8 from sago leaves and the isolation of FBAld cDNA from sago palm. The isolated sago FBAld (msFBAld cDNA has total length of 1288 bp with an open reading frame of 1020 bp and a predicted to encode for a protein of 340 amino acid resides. The predicted protein shared a high degree of homology with Class-I FBAld from other plants. Meanwhile, the msFBAld gene spanned 2322 bp and consisted of five exons. Conserved domain search identified fifteen catalytically important amino acids at the active site and phylogenetic tree revealed localization of msFBAld in the chloroplast. A molecular 3D-structure of msFBAld was generated by homology modeling and a Ramachandran plot with 86.7% of the residues in the core region, 13.4% in the allowed region with no residues in the disallowed region. The modeled structure is a homotetramer containing an (/(-TIM-barrel at the center. Superimposition of the model with Class-I aldolases identified a catalytic dyad, Lys209-Glu167, which could be involved in the Schiff's base formation and aldol condensation. Apart from that, overproduction of the recombinant msFBAld in Escherichia coli resulted in increased tolerance towards salinity.

Downregulation of adaptor protein MyD88 compromises the angiogenic potential of B16 murine melanoma

Science.gov (United States)

Araya, Paula; Nuñez, Nicolás Gonzalo; Mena, Hebe Agustina; Bocco, José Luis; Negrotto, Soledad; Maccioni, Mariana

2017-01-01

The mechanisms that link inflammatory responses to cancer development remain a subject of intense investigation, emphasizing the need to better understand the cellular and molecular pathways that create a tumor promoting microenvironment. The myeloid differentiation primary response protein MyD88 acts as a main adaptor molecule for the signaling cascades initiated from Toll-like receptors (TLRs) and the interleukin 1 receptor (IL-1R). MyD88 has been shown to contribute to tumorigenesis in many inflammation-associated cancer models. In this study, we sought to better define the role of MyD88 in neoplastic cells using a murine melanoma model. Herein, we have demonstrated that MyD88 expression is required to maintain the angiogenic switch that supports B16 melanoma growth. By knocking down MyD88 we reduced TLR-mediated NF-κB activation with no evident effects over cell proliferation and survival. In addition, MyD88 downregulation was associated with a decrease of HIF1α levels and its target gene VEGF, in correlation with an impaired capability to induce capillary sprouting and tube formation of endothelial cells. Melanomas developed from cells lacking MyD88 showed an enhanced secretion of chemoattractant ligands such as CCL2, CXCL10 and CXCL1 and have an improved infiltration of macrophages to the tumor site. Our results imply that cell-autonomous signaling through MyD88 is required to sustain tumor growth and underscore its function as an important positive modulator of tumor angiogenesis. PMID:28662055

Estimation of caffeine intake in Japanese adults using 16 d weighed diet records based on a food composition database newly developed for Japanese populations.

Science.gov (United States)

Yamada, Mai; Sasaki, Satoshi; Murakami, Kentaro; Takahashi, Yoshiko; Okubo, Hitomi; Hirota, Naoko; Notsu, Akiko; Todoriki, Hidemi; Miura, Ayako; Fukui, Mitsuru; Date, Chigusa

2010-05-01

Previous studies in Western populations have linked caffeine intake with health status. While detailed dietary assessment studies in these populations have shown that the main contributors to caffeine intake are coffee and tea, the wide consumption of Japanese and Chinese teas in Japan suggests that sources of intake in Japan may differ from those in Western populations. Among these teas, moreover, caffeine content varies widely among the different forms consumed (brewed, canned or bottled), suggesting the need for detailed dietary assessment in estimating intake in Japanese populations. Here, because a caffeine composition database or data obtained from detailed dietary assessment have not been available, we developed a database for caffeine content in Japanese foods and beverages, and then used it to estimate intake in a Japanese population. The caffeine food composition database was developed using analytic values from the literature, 16 d weighed diet records were collected, and caffeine intake was estimated from the 16 d weighed diet records. Four areas in Japan, Osaka (Osaka City), Okinawa (Ginowan City), Nagano (Matsumoto City) and Tottori (Kurayoshi City), between November 2002 and September 2003. Two hundred and thirty Japanese adults aged 30-69 years. Mean caffeine intake was 256.2 mg/d for women and 268.3 mg/d for men. The major contributors to intake were Japanese and Chinese teas and coffee (47 % each). Caffeine intake above 400 mg/d, suggested in reviews to possibly have negative health effects, was seen in 11 % of women and 15 % of men. In this Japanese population, caffeine intake was comparable to the estimated values reported in Western populations.

D.3.3 PLOT Persuasive Learning Design Framework

DEFF Research Database (Denmark)

Gram-Hansen, Sandra Burri

2012-01-01

In this third and final deliverable of WP3: Persuasive Learning Designs, the theoretical cross field between persuasion and learning and the practical analysis of the technological learning tools and products which are currently related to the PLOT project, namely the GLOMaker and the 3ET tool......, are linked together as persuasive learning designs are defined and exemplified through the four e-PLOT cases. Based on the literary study of D.3.1 as well as the subsequent discussions and reflections regarding the theoretical foundation and practical application of persuasive learning technologies......-PLOT work cases. In conclusion, the report presents a number of suggestions regarding the improvement of the two learning tools, which from a theoretical perspective will enhance the persuasive potential, and which can be taken into consideration in WP4 and 5....

Deliverable d6.1SME and Stakeholder Study

DEFF Research Database (Denmark)

Wagtmann, Maria Anne; Afroz Alam, Sama; Baird, Alf

2009-01-01

-learning courses and study programmes from internationally renowned institutions could be equivalent to a full-time study semester abroad. This might hint towards different perceptions of degrees from companies depending on the way these degrees were obtained. This aspect requires further research based on, e...... The SME and Stakeholder Study was an initial exercise to identify the education needs of the maritime industry [1] and maritime SMEs in particular. The study focused on five North Sea region countries: Denmark, Germany, Norway, Sweden and the UK, but did not look at these countries exclusively....... The study was based on stakeholder views obtained from an internet-based questionnaire [2] and combined them with findings from literature. The key themes of the questionnaire were: o The types of education used in the responding organisations o The relevance of potential education offering types to SMEs...

A study of the reactions 14C( vector d, dprime)14C and 14C ( vector d, p)15C at 16.0 MeV

International Nuclear Information System (INIS)

Murillo, G.; Sen, S.; Darden, S.E.

1994-01-01

Cross-section and vector-analyzing-power measurements for 14 C(d, d prime) and 14 C(d, p) reactions have been carried out for E d =16 MeV. The inelastic-scattering data have been analyzed using the DWBA with a collective and a microscopic model form-factor and also by using the coupled-channels formalism with a vibrational model form-factor. It is observed that while the cross-section angular-distribution data for the two 2 + states at E x =7.012 and 8.318 MeV are very similar, the corresponding vector analyzing powers are quite different. The results of the analyses indicate that the distinctive characteristics probably arise from the difference in the relative importance of the proton and neutron components in the transition amplitude. The 3 - state at E x =6.728 MeV is identified as predominantly a 1p-3h state. Although the deformation parameters are relatively large, the single-particle structure aspects play a more dominant role than channel-coupling effects in populating the inelastic states. The transfer reaction data have been analyzed using the DWBA for bound and unbound states. The importance of two-step processes has been investigated via coupled-reaction-channels calculations. The g.s. and the states with excitation energies 0.770, 3.103 and 4.78 MeV in 15 C are populated primarily by a one-step process with a small two-step contribution in the case of the 3.103 MeV state. The 4.22 MeV state is populated predominantly by two-step processes. The 4.78 and the 5.83 MeV states have been identified as 1p-2h and 3p-4h, [3]/[2] + state, respectively, in an earlier report. There is close similarity in the level structures and reaction mechanisms between the states of 15 C and 17 O populated via the (d, p) reaction. ((orig.))

D22 Analysis of Pilot

NARCIS (Netherlands)

Boyle, Elizabeth; MacGregor, Sharon; Van Rosmalen, Peter; Manea, Madalina; Penanen, Tiina

2015-01-01

The evaluation of the CHERMUG games was carried out in 3 phases which contributed in different ways to the game development and evaluation. Different cohorts of staff and students were involved in each phase and a detailed account of the list of pilot institutions is shown in Deliverable 21. Phase 1

Analyzing powers for the three-nucleon breakup reaction 1H(d vector,p)pn at 16 MeV

International Nuclear Information System (INIS)

Brown, R.E.; Ohlsen, G.G.; Correll, F.D.; Hardekopf, R.A.; Jarmie, N.

1980-01-01

Analyzing powers for the 1 H(d,p)pn reaction were measured at 16.0 MeV and beam polarization of approximately 0.82. Similar data for the elastic scattering 1 H(d,p) 2 H were also taken. The breakup analyzing power A/sub xz/, which attains the largest magnitude, is shown as a function of excitation energy. Angular distributions of elastic and breakup analyzing powers are compared; large differences are noted for A/sub xx/ and A/sub xz/. It is found that 1-MeV energy bins are too large to use in the study of singlet-state effects. 2 figures

Implementation of a Dynamic Mooring Solver (MOODY) into a wave to wire model of a simple WEC

DEFF Research Database (Denmark)

Ferri, Francesco; Palm, Johannes

This report forms the deliverable D4.6 of the Structural Design of Wave Energy Devices (SDWED) project. The main objective of the report is to shed light on the implementation of a simple floating wave energy converter (fWEC) numerical model coupled with a dynamic model of the reaction system. Th...

Detection of thin wall regions of unruptured cerebral aneurysms by ECG synchronous reconstruction 3D-CT angiography (4D-CTA) using 16 slices per rotation CT

International Nuclear Information System (INIS)

Fujita, Shigekiyo

2004-01-01

The objective of this study was to evaluate the capability of electrocardiogram (ECG) synchronous reconstruction 3D-CT angiography (4D-CTA) using 16 sequence MD-CT to detect weak portions of unruptured cerebral aneurysm. 4D-CT angiography of unruptured cerebral aneurysms was performed on 26 patients, 28 cerebral aneurysms, using 16 sequence MD-CT (GE, HiLight Matrix II). Contrast material of iodine (300 mg/ml) was injected over 30 sec period into the ante-cubital vein with a rate of 0.06 ml/Kg/sec. ECG synchronous reconstruction images (10 images at intervals of 10% between R-R of ECG) were generated (GE, Workstation Advantage 4.1). After careful inspection of the wall motion of an aneurysm from many aspects, cine images were made from several directions. Acquisition of data required 9 seconds, total volume data were generated within 15 minutes, and ECG synchronous reconstruction image processing was performed in about 5 minutes. Animation creation for one direction was completed within one minute. Even in 3-mm aneurysms, changes of its form and size within a heartbeat were fully observed. Timing of maximum and minimum sizes were also recognized. The pulsatile changes and nipple extent, bleb, daughter, and dome of aneurysms were well visualized. The projecting motion of the pulsatory enlargement of nipple was detected in nine cases, and definite increases in bleb sizes were detected in five cases. Since the easily reptured thin walled portion of a cerebral aneurysm can be recognized by this method, 4D-CT angiography is likely to become indispensable in judging how to cope with unruptured cerebral aneurysms, in deciding whether to operate or observe. (author)

Measurement of the D/H, 18O/16O, and 17O/16O Isotope Ratios in Water by Laser Absorption Spectroscopy at 2.73 μm

Directory of Open Access Journals (Sweden)

Tao Wu

2014-05-01

Full Text Available A compact isotope ratio laser spectrometry (IRLS instrument was developed for simultaneous measurements of the D/H, 18O/16O and 17O/16O isotope ratios in water by laser absorption spectroscopy at 2.73 μm. Special attention is paid to the spectral data processing and implementation of a Kalman adaptive filtering to improve the measurement precision. Reduction of up to 3-fold in standard deviation in isotope ratio determination was obtained by the use of a Fourier filtering to remove undulation structure from spectrum baseline. Application of Kalman filtering enables isotope ratio measurement at 1 s time intervals with a precision (<1‰ better than that obtained by conventional 30 s averaging, while maintaining a fast system response. The implementation of the filter is described in detail and its effects on the accuracy and the precision of the isotope ratio measurements are investigated.

A new DoD initiative: the Computational Research and Engineering Acquisition Tools and Environments (CREATE) program

International Nuclear Information System (INIS)

Arevalo, S; Atwood, C; Bell, P; Blacker, T D; Dey, S; Fisher, D; Fisher, D A; Genalis, P; Gorski, J; Harris, A; Hill, K; Hurwitz, M; Kendall, R P; Meakin, R L; Morton, S; Moyer, E T; Post, D E; Strawn, R; Veldhuizen, D v; Votta, L G

2008-01-01

In FY2008, the U.S. Department of Defense (DoD) initiated the Computational Research and Engineering Acquisition Tools and Environments (CREATE) program, a $360M program with a two-year planning phase and a ten-year execution phase. CREATE will develop and deploy three computational engineering tool sets for DoD acquisition programs to use to design aircraft, ships and radio-frequency antennas. The planning and execution of CREATE are based on the 'lessons learned' from case studies of large-scale computational science and engineering projects. The case studies stress the importance of a stable, close-knit development team; a focus on customer needs and requirements; verification and validation; flexible and agile planning, management, and development processes; risk management; realistic schedules and resource levels; balanced short- and long-term goals and deliverables; and stable, long-term support by the program sponsor. Since it began in FY2008, the CREATE program has built a team and project structure, developed requirements and begun validating them, identified candidate products, established initial connections with the acquisition programs, begun detailed project planning and development, and generated the initial collaboration infrastructure necessary for success by its multi-institutional, multidisciplinary teams

Urban strategies for Waste Management in Tourist Cities. D2.7: Compendium of waste management practices in pilot cities and best practices in touristic cities

OpenAIRE

Gruber, Iris; Mayerhofer, Johannes; Obersteiner, Gudrun; Ramusch, Roland; Romein, A.; Eriksson, Mattias; Grosse, Juliane; MC. Nascimento, Gisela; Bjorn Olsen, Trine; de Luca, Claudia; Zapata Aranda, Pilar; Kazeroni, Marie; Kovacs, Ernest

2017-01-01

This report (Deliverable D2.7) refers to URBANWASTE Work Package 2, Task 2.8. Under this Task the current waste prevention and management practices in the URBANWASTE pilot cases are investigated and best practices coming from the EU context (focussing on touristic processes) are identified. This document shall support the selection of innovative strategies to be carried out within Work Package WP 4. A comparative policy review of national waste management strategies and targets in the Europea...

Data Management Plan

DEFF Research Database (Denmark)

Hansen, Ernst Jan de Place; Vogelsang, Stefan; Freudenberg, Peggy

2015-01-01

This document describes the Data Management Plan (DMP) (first version), relating to RIBuild WP8, deliverable D8.1. The DMP include description of data sets, standards and metadata, data sharing and archiving and preservation of data.......This document describes the Data Management Plan (DMP) (first version), relating to RIBuild WP8, deliverable D8.1. The DMP include description of data sets, standards and metadata, data sharing and archiving and preservation of data....

Deliverable D4.2. Design variables for durability

NARCIS (Netherlands)

Visser, J.H.M.

2015-01-01

On January 1st 2012, the European project SUS-CON has been started: “SUStainable, innovative and energy efficient CONcrete, based on the integration of all waste materials” (grant agreement no: 285463). The SUS-CON project aims at developing new technology routes to integrate waste materials in the

D5.1 Dissemination Plan

DEFF Research Database (Denmark)

Buus, Lillian; Ryberg, Thomas; Eleftheriou, Paraskevi

2009-01-01

at defining the dissemination goals as well as the project’s target audience and channels through which the EATrain2 solution is going to be promoted. It also includes partners competences in the dissemination area and detailed schedule of events thematically related to the project’s scope. The deliverable...

D8.1 Socio-economic business model

DEFF Research Database (Denmark)

Dalsgaard, Henrik; Aagaard, Morten

2011-01-01

This deliverable describes an exploitation plan trying to specify the most effective route to maximize distribution and take-up of the HANDS toolset by those involved with the care of young people with autism, and associated conditions....

A novel aberrant splicing mutation of the PEX16 gene in two patients with Zellweger syndrome

NARCIS (Netherlands)

Shimozawa, Nobuyuki; Nagase, Tomoko; Takemoto, Yasuhiko; Suzuki, Yasuyuki; Fujiki, Yukio; Wanders, Ronald J. A.; Kondo, Naomi

2002-01-01

Human Pex16p, a peroxisomal membrane protein composed of 336 amino acids, plays a central role in peroxisomal membrane biogenesis. A nonsense mutation (R176ter) in the PEX16 gene has been reported in the case of only one patient (D-01) belonging to complementation group D of the peroxisome

The N=16 subshell closure; La fermeture de sous-couche N=16

Energy Technology Data Exchange (ETDEWEB)

Obertelli, A

2005-09-01

The sequence of magic numbers for stable nuclei is now well understood. However the magnitude of shell gap may evolve from stability to drip line. Several observables show that N = 16 neutron-rich isotones present a higher stability compared to their neighbors on the N-Z chart. The spectroscopy of the levels of Ne{sup 27}, involving sd and fp shells, has allowed us to study the evolution of the nuclear shells responsible for the structure changes in N 16 isotones. In this framework we have studied the neutron transfer reaction Ne{sup 26}(d,p)Ne{sup 27} by inverted kinematics at 9,7 MeV/u. A cryogenic D{sub 2} target (17 mg.cm{sup -2}) has been used. The use of the magnetic spectrometer Vamos and that of the Exogam photon detector in coincidence operating mode has allowed us to achieve the spectroscopy of Ne{sup 27}. The results show a reduction in the gap between sd and fp shells for N = 17 isotones as we go from stability toward the neutron drip line. We have also performed a theoretical study in mean-field theory and beyond it through configuration mixing so that we can see the evolution of the isospin of the N = 16 subshell's closure. We have used a HFB (Hartree-Fock-Bogoliubov) with the finite range D1S effective interaction. (A.C.)

When Crisis Calls for a Referendum.

Science.gov (United States)

Blanchfield, Terrence A.

1998-01-01

The school business official will be involved in many referenda over the course of a career. School budgets, capital projects, equipment acquisitions, school bus purchases, and emergency construction projects are among the most common situations requiring a referendum. A time frame is needed, and most states have guidelines spelling out procedures…

Cell cycle regulation by the Wee1 Inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line

International Nuclear Information System (INIS)

Hashimoto, Osamu; Shinkawa, Masako; Torimura, Takuji; Nakamura, Toru; Selvendiran, Karuppaiyah; Sakamoto, Masaharu; Koga, Hironori; Ueno, Takato; Sata, Michio

2006-01-01

Wee1 kinase plays a critical role in maintaining G2 arrest through its inhibitory phosphorylation of cdc2. In previous reports, a pyridopyrimidine molecule PD0166285 was identified to inhibit Wee1 activity at nanomolar concentrations. This G2 checkpoint abrogation by PD0166285 was demonstrated to kill cancer cells, there at a toxic highest dose of 0.5 μM in some cell lines for exposure periods of no longer than 6 hours. The deregulated cell cycle progression may have ultimately damaged the cancer cells. We herein report one of the mechanism by which PD0166285 leads to cell death in the B16 mouse melanoma cell line. Tumor cell proliferation was determined by counting cell numbers. Cell cycle distribution was determined by flow cytometry. Morphogenesis analysis such as microtubule stabilization, Wee1 distribution, and cyclin B location were observed by immunofluorescence confocal microscopy. An immunoblot analysis of cdc2-Tyr15, cyclin D, E, p16, 21, 27, and Rb. A real-time PCR of the mRNA of cyclin D were completed. In our experiment, B16 cells also dramatically abrogated the G2 checkpoint and were found to arrest in the early G1 phase by treatment with 0.5 μM for 4 hours observed by flow cytometry. Cyclin D mRNA decreased within 4 hours observed by Real-time PCR. Rb was dephosphrylated for 24 hours. However, B16 cells did not undergo cell death after 0.5 μM treatment for 24 hours. Immnofluoscence microscopy showed that the cells become round and small in the morphogenesis. More interesting phenomena were that microtubule stabilization was blocked, and Wee1 distribution was restricted after treatment for 4 hours. We analyzed the effect of Wee1 inhibitor PD0166285 described first by Wang in the G2 transition in the B16 melanoma cell line. The inhibitor PD0166285 abrogated G2/M checkpoint inducing early cell division. Moreover, we found that the treatment of cells with the inhibitor is related to microtubule stabilization and decrease in cyclin D transcription

Deliverable D1: Engineering study of the Hg converter

CERN Document Server

K. Samec et al.

The development of high-power converter targets otherwise known as neutron sources is today the focus of much attention, driven by the need for ever greater densities of neutron fluxes which are required in the fundamental sciences such as neutron imagery, isotope production and also for the more long-term goal of realising a hybrid sub-critical nuclear reactor. The neutrons in a converter target are produced by a process known in physics as spallation whereby a heavy Z atom releases neutrons below 20 [MeV] when hit by an incoming proton.The Eurisol initiative seeks to develop such an isotope production facility to provide the scientific community with the means to achieving high yields of isotopes and extending the variety of isotopes thus produced towards more exotic types rarely seen in existing facilities.The proposed ISOL facility would use both (a) several 100 kW proton beams on a thick solid target to produce RIBs directly, and (b) a liquid metal 1–5 MW ‘converter’ target to release high fluxes o...

D.3.2 PLOT Persuasive Learning Design Framework

DEFF Research Database (Denmark)

Gram-Hansen, Sandra Burri; Schärfe, Henrik; Winther-Nielsen, Nicolai

2011-01-01

of the technological learning tools and products which are currently related to the PLOT project, namely the GLOMaker and the 3ET tool, and a selection of GLOs and learning exercises. The primary focus of the analysis is to explore how the theoretical perspectives presented in D.3.1 are represented in these tools...... as an: ‚Internal report for project use containing an empirically-based assessment of existing systems and their potential in terms of learning and persuasion. This will be used as a discussion document by the consortium.‛ To meet the requirements of this deliverable, this documents presents analysis......, in particular the notions of persuasive design and constructive alignment. Whilst the report provides a persuasive design perspective on the technologies related to Euro PLOT, it must be stressed that if the document is to function as a basis for further discussion within the consortium, the partners...

The effect of stent coating on stent deliverability: direct randomised comparison of drug eluting and bare metal stents using the same stent platform.

Science.gov (United States)

Siminiak, Tomasz; Link, Rafał; Wołoszyn, Maciej; Kałmucki, Piotr; Baszko, Artur

2012-01-01

There is certain experimental and clinical evidence indicating that the covering of bare metal stents (BMS) with drug eluting polymers to produce drug eluting stents (DES) results in increased stent stiffness and modifies the mechanical properties of the stent platform. In addition, it has been speculated that the mechanical performance of DES, compared to BMS, may be related to the type of polymer used to cover stents. We aimed at evaluating the deliverability of DES with a lactate based biodegradable polymer and BMS in patients with stable coronary artery disease in a prospective randomised study. One hundred eleven consecutive patients (age: 36-77, mean 58.8 years) scheduled for routine angioplasty due to stable coronary disease were randomised to receive BMS (Chopin II(TM), Balton, Poland) or paclitaxel eluting stent (Chopin Luc(TM), Balton, Poland) using the same metal platform. Only patients scheduled for angioplasty using the direct implantation technique of a single stent were randomised. The exclusion criteria included patients 〉 80 years, multivessel disease and reference diameter of the target vessel 〉 3.5 mm. In the BMS group (n = 55; 35 males and 20 females), the mean diameter of implanted stents was 3.09 ± 0.40 and the mean length was 11.37 ± 2.80, whereas in the DES group (n = 56; 34 males and 22 females) the mean stent sizes were 3.02 ± 0.34 and 17.90 ± 7.38 mm, respectively (p 〉 0.05 for length). The groups did not significantly differ regarding the frequency of stent implantation to particular coronary vessels. The direct stenting technique was attempted and failed, leading to the stents' implantation after predilatation in five patients in the BMS group and six patients in the DES group. Failure of stent implantation and subsequent implantation of another stent type was observed in no BMS patients and in one DES patient (NS). Although stent covering with lactate based drug eluting polymer may increase its stiffness, it does not affect

Functional description of the monitoring and observability detailed concepts for the Pan-European Control Schemes

DEFF Research Database (Denmark)

Marinelli, Mattia; Pertl, Michael; Rezkalla, Michel M.N.

2017-01-01

Deliverable D5.4 outlines the methodology and the topics analysed in T5.4 for deriving PanEuropean observables within the Web-of-Cells (WoC) concept. Observables are derived by analysing traditional instability events typical of large power systems.......Deliverable D5.4 outlines the methodology and the topics analysed in T5.4 for deriving PanEuropean observables within the Web-of-Cells (WoC) concept. Observables are derived by analysing traditional instability events typical of large power systems....

Data Management Plan

DEFF Research Database (Denmark)

Hansen, Ernst Jan de Place; Sørensen, Nils Lykke

2016-01-01

This document describes the Data Management Plan (DMP) (second version), relating to RIBuild WP8, deliverable D8.1. It draws the first lines for how data can be made findable, accessible, interoperable and re-usable after the project period.......This document describes the Data Management Plan (DMP) (second version), relating to RIBuild WP8, deliverable D8.1. It draws the first lines for how data can be made findable, accessible, interoperable and re-usable after the project period....

UPWIND Metrology, Deliverable D 1A2.1, List of measurement Parameters

DEFF Research Database (Denmark)

Hansen, Kurt Schaldemose

performance measurements - Improvement of aerodynamic codes - Assessment of wind resources In general terms the uncertainty of the testing techniques and methods are typically much higher than the need. Since this problem covers many areas of wind energy, the work package is de-fined as a crosscutting...... activity. The problem is especially relevant for the following areas: Production related - Power performance testing especially in wind farms - Testing of turbine improvements in the order of several percent - Testing of aerodynamic codes - Testing of turbine response to effects such as turbulence...... profiles, turbulence, surface shear recovery distances etc) - Measurements of the interaction wind farms and microclimate The objectives of the metrology work package are to develop metrology tools in wind energy to significantly enhance the quality of measurement and testing techniques. The development...

R and D Requirements, RF Gun Mode Studies, FEL-2 Steady-State Studies, Preliminary FEL-1 Time-Dependent Studies, and Preliminary Layout Option Investigation

International Nuclear Information System (INIS)

Byrd, John; Corlett, John; Doolittle, Larry; Fawley, William; Lidia, Steven; Penn, Gregory; Ratti, Alex; Staples, John; Wilcox Russell; Wurtele, Jonathan; Zholents, Alexander

2005-01-01

This report constitutes the third deliverable of LBNLs contracted role in the FERMI (at) Elettra Technical Optimization study. It describes proposed RandD activities for the baseline design of the Technical Optimization Study, initial studies of the RF gun mode-coupling and potential effects on beam dynamics, steady-state studies of FEL-2 performance to 10 nm, preliminary studies of time-dependent FEL-1 performance using electron bunch distribution from the start-to-end studies, and a preliminary investigation of a configuration with FEL sinclined at a small angle from the line of the linac

3D-Spiral Small Antenna Design and Realization for Biomedical Telemetry in the MICS band

Directory of Open Access Journals (Sweden)

A. K. Skrivervik

2009-12-01

Full Text Available This work presents the design and realization procedure of small implantable antenna for biotelemetry applications. The radiator occupies a volume smaller than 3 cm3 (without its biocompatible insulation, is well matched within the Medical Implanted Communications System band and shows an adequate gain (-28.5 dB while introduced in the appropriate equivalent body medium. The latter is a homogeneous phantom with muscle dielectric properties. A prototype has been manufactured and measurements agree with theoretical predictions. Particular attention is paid to the building requirements such as the presence of glue. Specific Absorption Rate (SAR distribution has been computed evaluating the maximum power deliverable to the antenna in order to respect the regulated SAR limitation.

E-learning Programmes and Courses Evaluation Report

DEFF Research Database (Denmark)

Badger, Merete; Prag, Sidsel-Marie Winther; Monaco, Lucio

the development, testing, and evaluation of a series of applications for training and entrepreneurship in the field of sustainable energy (project work package 2, 3, and 4). This report describes the project outcomes related to this work stream with focus on E-learning programmes and courses. It represents...... the project deliverable “D3.4 E-learning Programmes and Courses Evaluation Report”. The applications developed for entrepreneurship will be described and evaluated in the project deliverable “D4.3 e-link evaluation report”. The second work stream (work package 5) covers the development of E......-infrastructure eduGAIN2. The access point is a web portal – the VCH Portal – which is used to manage users and groups. The E-infrastructure of VCH will be described and evaluated in the project deliverable “5.4 Virtual Campus Hub Technology Evaluation Report”. The E-learning applications described in this report...

webinos project deliverable: Phase 1 Security Framework

OpenAIRE

webinos consortium

2011-01-01

The webinos project aims to deliver a cross-device web application runtime environment, providing a unified development platform and standardized inter-device communication and interaction. This document contains the first iteration of the technical security and privacy framework designed for the webinos project. It accompanies two other documents - D3.1 System Specification and D3.2 API Specifications - and refers to concepts developed in them. The security and privacy architecture aims to p...

Allele frequency data for 16 STR loci in the Vietnamese population.

Science.gov (United States)

Shimada, I; Brinkmann, B; Tuyen, N Q; Hohoff, C

2002-08-01

The short tandem repeat systems ACTBP2, D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX and FGA were studied in a population sample from Vietnam (178 individuals, mainly from the Hanoi area). The 16 loci met Hardy-Weinberg expectations and possess a combined power of discrimination greater than 0.9999999999999999998 and a combined power of exclusion greater than 0.99999994 in this Vietnamese population.

Anti-pancreatic cancer deliverables from sea: first-hand evidence on the efficacy, molecular targets and mode of action for multifarious polyphenols from five different brown-algae.

Directory of Open Access Journals (Sweden)

Sheeja Aravindan

Full Text Available Pancreatic cancer (PC remains the fourth leading cause of cancer death with an unacceptable survival that has remained relatively unchanged over the past 25 years. The presence of occult or clinical metastases at the time of diagnosis together with the lack of effective chemotherapies pose a dire need for designing new and targeted therapeutic deliverables that favors the clinical outcome. Herein, we investigated the anti-tumorigenic potential of polyphenols from five different brown-algae in human PC cells (MiaPaCa-2, Panc-1, BXPC-3 and Panc-3.27. Total anti-oxidant capacity (TAC analysis on stepwise polyphenol separations with increasing polarity (Hexane-DCM-EA-methanol identified high levels of TAC in DCM and EA extractions across all seaweeds assessed. All DCM and EA separated polyphenols induced a dose-dependent and sustained (time-independent inhibition of cell proliferation and viability. Further, these polyphenols profoundly enhanced DNA damage (acridine orange/Ethidium bromide staining and DNA fragmentation in all the cell lines investigated. More importantly, luciferase reporter assay revealed a significant inhibition of NFκB transcription in cells treated with polyphenols. Interestingly, QPCR analysis identified a differential yet definite regulation of pro-tumorigenic EGFR, VEGFA, AKT, hTERT, kRas, Bcl2, FGFα and PDGFα transcription in cells treated with DCM and EA polyphenols. Immunoblotting validates the inhibitory potential of seaweed polyphenols in EGFR phosphorylation, kRas, AurKβ and Stat3. Together, these data suggest that intermediate polarity based fractions of seaweed polyphenols may significantly potentiate tumor cell killing and may serve as potential drug deliverable for PC cure. More Studies dissecting out the active constituents in potent fractions, mechanisms of action and synergism, if any, are warranted and are currently in process.

A review of the Italian fast reactor programme

International Nuclear Information System (INIS)

Pierantoni, F.; Tavoni, R.

1989-01-01

The result of the referenda held in Italy in November 1987 on some nuclear issues, and the subsequent attitude of the main political parties led to a sharp cut-back of nuclear activities in Italy as far as both construction and operation of nuclear plants are concerned. A new PEN (National Energy Plan), already approved by the government for submission to parliament, calls, however, for a programme of research and industrial development of reactors with inherent and passive safety features. Such a programme must be carried out in a framework of international co-operation. In addition to the Italian contribution to R and D activities performed under the European Agreements some further activities have been performed on Esmeralda Programme, seismic isolation, Integrity of structures and Primary and Intermediate Pumps. (author). 2 tabs

16O resonances near the 4α threshold through the 12C(6Li,d) reaction

Science.gov (United States)

Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Duarte, J. L. M.; Rodrigues, C. L.; Souza, M. A.; Horodynski-Matsushigue, L. B.; Ukita, G. M.; Cappuzzello, F.; Cunsolo, A.; Cavallaro, M.; Agodi, C.; Foti, A.

2014-02-01

Background: Resonances around xα thresholds in light nuclei are recognized to be important in basic aspects of nuclear structure. However, there is scarce experimental information associated with them. Purpose: We study the α-clustering phenomenon in resonant states around the 4α threshold (14.44 MeV) in the 16O nucleus. Method: The 12C(6Li,d )16O reaction was investigated with an unprecedented resolution at a bombarding energy of 25.5 MeV by employing the São Paulo Pelletron-Enge-Spectrograph facility and the nuclear emulsion technique. Results: Several narrow resonances were populated and the energy resolution of 15 keV allows for the separation of doublet states that were not resolved previously. The upper limits for the resonance widths in this region were extracted. The angular distributions of the absolute differential cross section associated with four natural parity quasibound states are presented and compared to distorted wave Born approximation predictions. Conclusions: Narrow resonances not previously reported in the literature were observed. This indicates that the α-cluster structure information in this region should be revised.

Simulation of Porous Medium Hydrogen Storage - Estimation of Storage Capacity and Deliverability for a North German anticlinal Structure

Science.gov (United States)

Wang, B.; Bauer, S.; Pfeiffer, W. T.

2015-12-01

Large scale energy storage will be required to mitigate offsets between electric energy demand and the fluctuating electric energy production from renewable sources like wind farms, if renewables dominate energy supply. Porous formations in the subsurface could provide the large storage capacities required if chemical energy carriers such as hydrogen gas produced during phases of energy surplus are stored. This work assesses the behavior of a porous media hydrogen storage operation through numerical scenario simulation of a synthetic, heterogeneous sandstone formation formed by an anticlinal structure. The structural model is parameterized using data available for the North German Basin as well as data given for formations with similar characteristics. Based on the geological setting at the storage site a total of 15 facies distributions is generated and the hydrological parameters are assigned accordingly. Hydraulic parameters are spatially distributed according to the facies present and include permeability, porosity relative permeability and capillary pressure. The storage is designed to supply energy in times of deficiency on the order of seven days, which represents the typical time span of weather conditions with no wind. It is found that using five injection/extraction wells 21.3 mio sm³ of hydrogen gas can be stored and retrieved to supply 62,688 MWh of energy within 7 days. This requires a ratio of working to cushion gas of 0.59. The retrievable energy within this time represents the demand of about 450000 people. Furthermore it is found that for longer storage times, larger gas volumes have to be used, for higher delivery rates additionally the number of wells has to be increased. The formation investigated here thus seems to offer sufficient capacity and deliverability to be used for a large scale hydrogen gas storage operation.

APOLLON. Multi-APprOach for high efficiency integrated and inteLLigent cONcentrating PV modules (Systems). Deliverable 7.10. Publication of environmental LCI dataset

Energy Technology Data Exchange (ETDEWEB)

Olson, C.L. [ECN Solar Energy, Petten (Netherlands)

2013-10-15

This deliverable makes available the life-cycle inventory used to calculate the energy payback time and the carbon footprint of the Apollon final concentrating photovoltaics (CPV) design developed.. The data below relates to one Apollon module. The results are to be published in Environmental Science and Technology, in a paper, 'Sustainability of Materials and Costs of Materials in a Mirror-based Concentrating Photovoltaic System'. Reference is made to the results for the Spectrolab triple junction solar cell in the following two studies: (1) 'Life cycle assessment of high-concentration photovoltaic systems' (Prog. Photovolt: Res. Appl., vol. 21, pp. 379-388, 2013), and (2) 'Life Cycle Analysis of Two New Concentrator PV Systems', in 23rd European Photovoltaic Solar Energy Conference, Valencia, Spain, 2008.

A new radiochemical assay for fructose-1,6-diphosphatase in human leucocytes

International Nuclear Information System (INIS)

Janssen, A.J.M.; Trijbels, F.J.M.

1982-01-01

Fructose-1,6-diphosphatase (D-fructose-1,6-diphosphate 1-phosphohydrolase, EC 3.1.3.11, FDPase) is one of the key enzymes of the gluconeogenic pathway. Measuring the activity both in the presence and in the absence of AMP yields the true FDPase activity, corrected for non-specific phosphatase activity. In this paper the authors introduce a new radiochemical assay for FDPase, based on the decarboxylating activity of 6-phosphogluconate dehydrogenase. One molecule [U- 14 C]fructose-1,6-diphosphate yields one molecule 14 CO 2 which can be captured in strongly basic solutions and counted in a liquid scintillation counter. (Auth.)

Diabetes ongoing sustainable care and treatment (DOST): A strategy for informational deliverance through visual dynamic modules sustained by near peer mentoring.

Science.gov (United States)

Joshi, Ankur; Arutagi, Vishwanath; Nahar, Nitin; Tiwari, Sharad; Singh, Daneshwar; Sethia, Soumitra

2016-01-01

The informational continuity for a diabetic patient is of paramount importance. This study on a pilot basis explores the process utility of structured educational modular sessions grounded on the principle of near-peer mentoring. Visual modules were prepared for diabetic patients. These modules were instituted to 25 diabetic patients in logical sequences. In the next phase, 4 persons of these 25 patients were designated as diabetic-diabetes ongoing sustainable care and treatment (DOST). Each diabetic-DOST was clubbed with two patients for modular session and informational deliverance during the next 7 days. Process analysis was performed with "proxy-indicators," namely, monthly glycemic status, knowledge assessment scores, and quality of life. Data were analyzed by interval estimates and through nonparametric analysis. Nonparametric analysis indicated a significant improvement in glycemic status in terms with fasting blood sugar (W = 78 z = 3.04, P = 0.002), 2 h-postprandial blood sugar (W = 54, z = 2.01, P = 0.035), and in knowledge score (χ 2 = 19.53, df = 3; P = 0.0002). Quality of life score showed significant improvement in 2 out of 7 domains, namely, satisfaction with treatment ([difference in mean score = 1.40 [1.94 to 0.85]) and symptom botherness (difference in mean score = 0.98 [1.3-0.65]). Because of inherent methodological limitations and innate biases, at this juncture no conclusive statement can be drawn. Although, primitive process evidences indicate the promising role of the diabetic-DOST strategy.

D1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neurons.

Directory of Open Access Journals (Sweden)

Khursheed A Wani

Full Text Available Dopamine signaling modulates voluntary movement and reward-driven behaviors by acting through G protein-coupled receptors in striatal neurons, and defects in dopamine signaling underlie Parkinson's disease and drug addiction. Despite the importance of understanding how dopamine modifies the activity of striatal neurons to control basal ganglia output, the molecular mechanisms that control dopamine signaling remain largely unclear. Dopamine signaling also controls locomotion behavior in Caenorhabditis elegans. To better understand how dopamine acts in the brain we performed a large-scale dsRNA interference screen in C. elegans for genes required for endogenous dopamine signaling and identified six genes (eat-16, rsbp-1, unc-43, flp-1, grk-1, and cat-1 required for dopamine-mediated behavior. We then used a combination of mutant analysis and cell-specific transgenic rescue experiments to investigate the functional interaction between the proteins encoded by two of these genes, eat-16 and rsbp-1, within single cell types and to examine their role in the modulation of dopamine receptor signaling. We found that EAT-16 and RSBP-1 act together to modulate dopamine signaling and that while they are coexpressed with both D1-like and D2-like dopamine receptors, they do not modulate D2 receptor signaling. Instead, EAT-16 and RSBP-1 act together to selectively inhibit D1 dopamine receptor signaling in cholinergic motor neurons to modulate locomotion behavior.

{sup 16}O resonances near 4α threshold through {sup 12}C({sup 6}Li,d) reaction

Energy Technology Data Exchange (ETDEWEB)

Rodrigues, M. R. D.; Borello-Lewin, T.; Miyake, H.; Horodynski-Matsushigue, L. B.; Duarte, J. L. M.; Rodrigues, C. L.; Faria, P. Neto de [Instituto de Física, Universidade de São Paulo, Caixa Postal 66318, CEP 05314-970, São Paulo, SP (Brazil); Cunsolo, A.; Cappuzzello, F.; Foti, A.; Agodi, C.; Cavallaro, M. [INFN - Laboratori Nazionali del Sud, Via S. Sofia 62, 95125 Catania (Italy); Napoli, M. di; Ukita, G. M. [Faculdade de Psicologia, Universidade de Santo Amaro, R. Prof. Eneas da Siqueira Neto, 340, CEP 04829-300, São Paulo, SP (Brazil)

2014-11-11

Several narrow alpha resonant {sup 16}O states were detected through the {sup 12}C({sup 6}Li,d) reaction, in the range of 13.5 to 17.5 MeV of excitation energy. The reaction was measured at a bombarding energy of 25.5 MeV employing the São Paulo Pelletron-Enge-Spectrograph facility and the nuclear emulsion technique. Experimental angular distributions associated with natural parity quasi-bound states around the 4α threshold are presented and compared to DWBA predictions. The upper limit for the resonance widths obtained is near the energy resolution (15 keV)

Final report

DEFF Research Database (Denmark)

Badger, Merete; Monaco, Lucio; Fransson, Torsten

2013-01-01

This report represents the deliverable D1.2 of project Virtual Campus Hub. The project runs from October 2011 to September 2013. The report is the core of the project’s 2nd periodic report, which was submitted to the European Commission on November 4th, 2013.......This report represents the deliverable D1.2 of project Virtual Campus Hub. The project runs from October 2011 to September 2013. The report is the core of the project’s 2nd periodic report, which was submitted to the European Commission on November 4th, 2013....

Contribution to the study of low-energy (d,p) reactions on light nuclei; Contribution a l'etude des reactions (d,p) a basse energie sur noyaux legers

Energy Technology Data Exchange (ETDEWEB)

Nguyen Van, S [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1967-05-15

This work is carried out with a view to analysing low energy (d,p) reactions on light nuclei measured at Grenoble or Algiers and suggesting a direct mechanism. The distorted wave approximation has been applied; this requires the development of programmes for the IBM 7044 computer at the 'Institut des Mathematiques Appliquees' in Grenoble. The (d,p) reactions on {sup 14}N, {sup 9}Be, {sup 22}Ne and {sup 16}O are dealt with. A calculation of the interference of the direct interaction and of resonating effects has been applied to {sup 16}O. (author) [French] Ce travail a pour but d'analyser les reactions (d,p) a basse energie sur noyaux legers, mesurees a Grenoble ou a Alger et qui suggerent un mecanisme direct. L'approximation des ondes distordues a ete appliquee, necessitant la mise au point de programmes sur l'ordinateur IBM 7044 de l'Institut des Mathematiques Appliquees de Grenoble. Des reactions (d,p) sur {sup 14}N, {sup 9}Be, {sup 22}Ne et {sup 16}O sont traitees. Un calcul de l'interference de l'interaction directe et des effets resonnants a ete applique a {sup 16}O. (auteur)

Folding model analyses of 12C-12C and 16O-16O elastic scattering using the density-dependent LOCV-averaged effective interaction

Science.gov (United States)

Rahmat, M.; Modarres, M.

2018-03-01

The averaged effective two-body interaction (AEI), which can be generated through the lowest order constrained variational (LOCV) method for symmetric nuclear matter (SNM) with the input [Reid68, Ann. Phys. 50, 411 (1968), 10.1016/0003-4916(68)90126-7] nucleon-nucleon potential, is used as the effective nucleon-nucleon potential in the folding model to describe the heavy-ion (HI) elastic scattering cross sections. The elastic scattering cross sections of 12C-12C and 16O-16O systems are calculated in the above framework. The results are compared with the corresponding calculations coming from the fitting procedures with the input finite range D D M 3 Y 1 -Reid potential and the available experimental data at different incident energies. It is shown that a reasonable description of the elastic 12C-12C and 16O-16O scattering data at the low and medium energies can be obtained by using the above LOCV AEI, without any need to define a parametrized density-dependent function in the effective nucleon-nucleon potential, which is formally considered in the typical D D M 3 Y 1 -Reid interactions.

16O+16O molecular nature of the superdeformed band of 32S and the evolution of the molecular structure

International Nuclear Information System (INIS)

Kimura, Masaaki; Horiuchi, Hisashi

2004-01-01

The relation between the superdeformed band of 32 S and 16 O+ 16 O molecular bands is studied by the deformed-basis antisymmetrized molecular dynamics with the Gogny D1S force. It is found that the obtained superdeformed band members of S have a considerable amount of the 16 O+ 16 O component. Above the superdeformed band, we have obtained two excited rotational bands which have more prominent character of the 16 O+ 16 O molecular band. These three rotational bands are regarded as a series of 16 O+ 16 O molecular bands which were predicted by using the unique 16 O- 16 O optical potential. As the excitation energy and principal quantum number of the relative motion increase, the 16 O+ 16 O cluster structure becomes more prominent but at the same time, the band members are fragmented into several states

Relation between D/H ratios and 18O /16O ratios in cellulose from linen and maize - Implications for paleoclimatology and for sindonology

Science.gov (United States)

DeNiro, Michael J.; Sternberg, Leonel D.; Marino, Bruno D.; Druzik, James R.

1988-09-01

The 18O /16O ratios of cellulose and the D/H ratios of cellulose nitrate were determined for linen, a textile produced from the fibers of the flax plant Linum usitatissimum, and for maize ( Zea mays) from a variety of geographic locations in Europe, the Middle East, and North and South America. The regression lines of δD values on δ 18O values had slopes of 5.4 and 5.8 for the two species. Statistical analysis of results reported in the only other study in which samples of a single species (the silver fir Abies pindrow) that grew under a variety of climatic conditions were analyzed yielded slopes of ~6 when δD values of cellulose nitrate were regressed on δ 18O values of cellulose. The occurrence of this previously unrecognized relationship in three species suggests it may obtain in other plants as well. Determining the basis for this relationship, which is not possible given current understanding of fractionation of the isotopes of oxygen and hydrogen by plants, should lead to increased understanding of how D/H and 18O /16O ratios in cellulose isolated from fossil plants are related to paleoclimates. The separation of most linen samples from Europe from those originating in the Middle East when δD values are plotted against δ 18O values suggests it may be possible to use the isotope ratios of cellulose prepared from the Shroud of Turin to resolve the controversy concerning its geographic origin.

TU-CD-304-08: Feasibility of a VMAT-Based Spatially Fractionated Grid Therapy Technique

Energy Technology Data Exchange (ETDEWEB)

Zhao, B; Liu, M; Huang, Y; Kim, J; Brown, S; Siddiqui, F; Chetty, I; Wen, N [Henry Ford Health System, Detroit, MI (United States); Jin, J [Georgia Regents University, Augusta, GA (Georgia)

2015-06-15

Purpose: Grid therapy (GT) uses spatially modulated radiation doses to treat large tumors without significant toxicities. Incorporating 3D conformal-RT or IMRT improved single-field GT by reducing dose to normal tissues spatially through the use of multiple fields. The feasibility of a MLC-based, inverse-planned multi-field GT technique has been demonstrated. Volumetric modulated arc therapy (VMAT) provides conformal dose distributions with the additional potential advantage of reduced treatment times. In this study, we characterize a new VMAT-based GT (VMAT-GT) technique with respect to its deliverability and dosimetric accuracy. Methods: A lattice of 5mm-diameter spheres was created as the boost volume within a large treatment target. A simultaneous boost VMAT (RapidArc) plan with 8Gy to the target and 20Gy to the boost volume was generated using the Eclipse treatment planning system (AAA-v11). The linac utilized HD120 MLC and 6MV flattening-filter free beam. Four non-coplanar arcs, with couch angles at 0, 45, 90 and 317° were used. Collimator angles were at 45 and 315°. The plan was mapped to a phantom. Calibrated Gafchromic EBT3 films were used to measure the delivered dose. Results: The VMAT plan generated a highly spatially modulated dose distribution in the target. D95%, D50%, D5% for the spheres and the targets in Gy were 18.9, 20.6, 23 and 8.0, 9.6, 14.8, respectively. D50% for a 1cm ring 1cm outside the target was 3.0Gy. The peak-to-valley ratio of this technique is comparable to previously proposed techniques, but the MUs were reduced by almost 50%. Film dosimetry showed good agreement between calculated and delivered dose, with an overall gamma passing rate of >98% (3% and 1mm). The point dose differences at sphere centers varied from 2–8%. Conclusion: The deliverability and dose calculation accuracy of the proposed VMAT-GT technique demonstrates that ablative radiation doses are deliverable to large tumors safely and efficiently.

Spectroscopic study of low-lying 16N levels

International Nuclear Information System (INIS)

Bardayan, Daniel W.; O'Malley, Patrick; Blackmon, Jeff C.; Chae, K.Y.; Chipps, K.; Cizewski, J.A.; Hatarik, Robert; Jones, K.L.; Kozub, R. L.; Matei, Catalin; Moazen, Brian; Nesaraja, Caroline D.; Pain, Steven D.; Paulauskas, Stanley; Peters, W.A.; Pittman, S.T.; Schmitt, Kyle; Shriner, J.F. Jr.; Smith, Michael Scott

2008-01-01

The magnitude of the 15N(n,gamma)16N reaction rate in asymptotic giant branch stars depends directly on the neutron spectroscopic factors of low-lying 16N levels. A new study of the 15N(d,p)16N reaction is reported populating the ground and first three excited states in 16N. The measured spectroscopic factors are near unity as expected from shell model calculations, resolving a long-standing discrepancy with earlier measurements that had never been confirmed or understood. Updated 15N(n,gamma)16N reaction rates are presented

Concept and Model - Kiwi project deliverable D2.8

DEFF Research Database (Denmark)

Durao, Frederico; Dolog, Peter

2009-01-01

The Concept and Model for personalisation serves several goals: •    Introducing relevant concepts of personalisation, user and group modelling, statistical model, reasoning and reason maintenance for personalisation. •    Reviewing the related work in personalisation and understanding how......, widget arrangement based on user activity and reasoning maintenance for generation of recommendations....

Overview of arc design options: Deliverable D2.1

CERN Document Server

Chance, Antoine

2016-01-01

This document describes the collider layouts to be taken into account for further detailed studies. The optimization of the arc cell lattice and the choice made on the dispersion suppressor are explained. The arc lattice is detailed with the procedures to tune the collider ring and to correct the chromaticity. The correction schemes of the orbit, of the dynamic aperture and of the spurious dispersion are detailed. Finally, the properties of the arc design at the injection energy are shown.

Cordycepin (3'-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression.

Science.gov (United States)

Yoshikawa, Noriko; Yamada, Shizuo; Takeuchi, Chihiro; Kagota, Satomi; Shinozuka, Kazumasa; Kunitomo, Masaru; Nakamura, Kazuki

2008-06-01

Cordyceps sinensis, a parasitic fungus on the larvae of Lepidoptera, has been used as a traditional Chinese medicine. We previously reported that the growth of B16-BL6 mouse melanoma (B16-BL6) cells was inhibited by cordycepin (3'-deoxyadenosine), an active ingredient of C. sinensis, and its effect was antagonized by MRS1191, a selective adenosine A3 receptor antagonist. In this study, the radioligand binding assay using [125I]-AB-MECA (a selective adenosine A3 receptor agonist) has shown that B16-BL6 cells express adenosine A3 receptors and that cordycepin binds to these receptors. We also confirmed the involvement of adenosine A3 receptors in the action of cordycepin using MRS1523 and MRS1220, specific adenosine A3 receptor antagonists. Next, indirubin, a glycogen synthase kinase-3beta (GSK-3beta) inhibitor, antagonized the growth suppression induced by cordycepin. Furthermore, the level of cyclin D1 protein in B16-BL6 cells was decreased by cordycepin using Western blot analysis. In conclusion, this study demonstrated that cordycepin inhibits the proliferation of B16-BL6 cells by stimulating adenosine A3 receptors followed by the Wnt signaling pathway, including GSK-3beta activation and cyclin D1 inhibition.

Finite strain transient creep of D16T alloy: identification and validation employing heterogeneous tests

Science.gov (United States)

Shutov, A. V.; Larichkin, A. Yu

2017-10-01

A cyclic creep damage model, previously proposed by the authors, is modified for a better description of the transient creep of D16T alloy observed in the finite strain range under rapidly changing stresses. The new model encompasses the concept of kinematic hardening, which allows us to account for the creep-induced anisotropy. The model kinematics is based on the nested multiplicative split of the deformation gradient, proposed by Lion. The damage evolution is accounted for by the classical Kachanov-Rabotnov approach. The material parameters are identified using experimental data on cyclic torsion of thick-walled samples with different holding times between load reversals. For the validation of the proposed material model, an additional experiment is analyzed. Although this additional test is not involved in the identification procedure, the proposed cyclic creep damage model describes it accurately.

WE-F-16A-05: Use of 3D-Printers to Create a Tissue Equivalent 3D-Bolus for External Beam Therapy

Energy Technology Data Exchange (ETDEWEB)

Burleson, S; Baker, J; Hsia, A; Xu, Z [Stony Brook Medicine, Stony Brook, NY (United States)

2014-06-15

Purpose: The purpose of this project is to demonstrate that a non-expensive 3D-printer can be used to manufacture a 3D-bolus for external beam therapy. The printed bolus then can be modeled in our treatment planning system to ensure accurate dose delivery to the patient. Methods: We developed a simple method to manufacture a patient-specific custom 3Dbolus. The bolus is designed using Eclipse Treatment Planning System, contoured onto the patients CT images. The bolus file is exported from Eclipse to 3D-printer software, and then printed using a 3D printer. Various tests were completed to determine the properties of the printing material. Percent depth dose curves in this material were measured with electron and photon beams for comparison to other materials. In order to test the validity of the 3D printed bolus for treatment planning, a custom bolus was printed and tested on the Rando phantom using film for a dose plane comparison. We compared the dose plane measured on the film to the same dose plane exported from our treatment planning system using Film QA software. The gamma-dose distribution tool was used in our film analysis. Results: We compared point measurements throughout the dose plane and were able to achieve greater than 95% passing rate at 3% dose difference and 3 mm distance to agreement, which is our departments acceptable gamma pixel parameters. Conclusion: The printed 3D bolus has proven to be accurately modeled in our treatment planning system, it is more conformal to the patient surface and more durable than other bolus currently used (wax, superflab etc.). It is also more convenient and less costly than comparable bolus from milling machine companies.

WE-F-16A-05: Use of 3D-Printers to Create a Tissue Equivalent 3D-Bolus for External Beam Therapy

International Nuclear Information System (INIS)

Burleson, S; Baker, J; Hsia, A; Xu, Z

2014-01-01

Purpose: The purpose of this project is to demonstrate that a non-expensive 3D-printer can be used to manufacture a 3D-bolus for external beam therapy. The printed bolus then can be modeled in our treatment planning system to ensure accurate dose delivery to the patient. Methods: We developed a simple method to manufacture a patient-specific custom 3Dbolus. The bolus is designed using Eclipse Treatment Planning System, contoured onto the patients CT images. The bolus file is exported from Eclipse to 3D-printer software, and then printed using a 3D printer. Various tests were completed to determine the properties of the printing material. Percent depth dose curves in this material were measured with electron and photon beams for comparison to other materials. In order to test the validity of the 3D printed bolus for treatment planning, a custom bolus was printed and tested on the Rando phantom using film for a dose plane comparison. We compared the dose plane measured on the film to the same dose plane exported from our treatment planning system using Film QA software. The gamma-dose distribution tool was used in our film analysis. Results: We compared point measurements throughout the dose plane and were able to achieve greater than 95% passing rate at 3% dose difference and 3 mm distance to agreement, which is our departments acceptable gamma pixel parameters. Conclusion: The printed 3D bolus has proven to be accurately modeled in our treatment planning system, it is more conformal to the patient surface and more durable than other bolus currently used (wax, superflab etc.). It is also more convenient and less costly than comparable bolus from milling machine companies

Steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone: A convenient synthesis, antiproliferation activity, structure-activity relationships, and role of heterocyclic moiety

Science.gov (United States)

Ke, Shaoyong; Shi, Liqiao; Zhang, Zhigang; Yang, Ziwen

2017-01-01

A series of steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone were designed and prepared by a convenient heterocyclization reaction. The in vitro anticancer activities for these obtained compounds were evaluated against human cancer cell lines (HepG2, Huh-7, and SGC-7901), which demonstrated that some of these heterocyclic pyrimidine derivatives exhibited significantly good cytotoxic activities against all tested cell lines compared with 5-fluorouracil (5-FU), especially, compound 3b exhibited high potential growth inhibitory activities against all tested cell lines with the IC50 values of 5.41 ± 1.34, 5.65 ± 1.02 and 10.64 ± 1.49 μM, respectively, which might be used as promising lead scaffold for discovery of novel anticancer agents. PMID:28290501

Deliverance from the "Dark Night of the Soul"

Science.gov (United States)

Kinnier, Richard T.; Dixon, Andrea L.; Scheidegger, Corey; Lindberg, Brent

2009-01-01

For many individuals, spiritual inspiration, clarity, or epiphany is often preceded by a "dark night of the soul". St. John of the Cross, a Spanish mystic of the 16th century, first described the concept. Today, the phrase "dark night of the soul" is usually associated with the crisis part of the journey to enlightenment. This article defines and…

Synthesis and antiproliferative activity of some A- and B modified D-homo lactone androstane derivatives

Directory of Open Access Journals (Sweden)

Savić Marina P.

2013-01-01

Full Text Available An efficient synthesis of several A- and B-modified D-homo lactone androstane derivatives from 3β-hydroxy-17-oxa-D-homoandrost-5-en-16-one (1 is reported. 17-Oxa-Dhomoandrost- 4-ene-3,16-dione (2, obtained by the Oppenauer oxidation of compound 1, was converted via the unstable intermediate 3,16-dioxo-4,17-dioxa-D-homoandrostane- 5α-carboxaldehyde (3 to 17-oxa-D-homo-3,5-seco-4-norandrostan-5-one-3-carboxylic acid (4, which was also obtained directly from compound 2. Compound 1 was acetylated to give 17-oxa-D-homoandrost-5-en-16-on-3β-yl acetate (5 which was then oxidized with chromium(VI-oxide in 50% acetic acid or with meta-chlorperbenzoic acid and chromium(VI-oxide to yield compounds 6-8 and 5α-hydroxy-17-oxa-D-homoandrostane- 6,16-dion-3β-yl acetate (9, respectively. The oximination of compound 9 gave a mixture of 6(E-hydroximino-5α-hydroxy-17-oxa-D-homoandrostan-16-on-3β-yl acetate (10 and 6(Z-hydroximino-5α-hydroxy-17-oxa-D-homoandrostan-16-on-3β-yl acetate (11, the hydrolysis of which gave 6(E-hydroximino-3β,5α-dihydroxy-17-oxa-D-homoandrostan- 16-one (12 and 6(Z-hydroximino-3β,5α-dihydroxy-17-oxa-D-homoandrostan-16-one (13. 6-Nitrile-17-oxa-5,6-seco-D-homoandrostane-5,16-dion-3β-yl acetate (14 was obtained under the Beckmann fragmentation of compounds 10 and 11. Only pure and stable compounds (1, 2, 4, 5, 9 and 14 were tested in vitro on six malignant cell lines (MCF-7, MDA-MB-231, PC-3, HeLa, HT-29, K562 and one non-tumor MRC-5 cell line. Significant antiproliferative activity against MDA-MB-231 cells showed compounds 1, 5 and 9, while compound 2 exhibited a strong antiproliferative activity. Only compound 14 showed weak antiproliferative activity against MCF-7 cells. All tested compounds were not toxic on MRC-5 cells, whereas Doxorubicin was highly toxic on these cells. [Projekat Ministarstva nauke Republike Srbije, br. 172021

Sampling system for fast single pulses; Realisation d'un dispositif d'echantillonnage d'un signal bref unique

Energy Technology Data Exchange (ETDEWEB)

Zenatti, D [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1969-07-01

Development of a device for the enlargement of the domain of application of classical oscilloscopes to the observation of fast single pulses by application of the sampling principle. Its principal characteristics are: Bandwidth of 700 MHz; Maximum sensibility of 50 mV; Maximum amplitude of input signal of {+-} 1 V; Number of samples of 16; Samples separation of 0,2 ns. (author) [French] Realisation d'un dispositif permettant d'elargir le domaine d'utilisation des oscilloscopes classiques en appliquant le principe de l'echantillonnage a l'observation d'un signal bref unique. Les principales caracteristiques sont les suivantes: Bande passante de 700 MHz; Sensibilite maximale de 50 mV; Amplitude maximale du signal a echantillonner de {+-} 1 V; Nombre de points d'echantillonnage de 16; Pas d'echantillonnage de 0,2 ns. (auteur)

Diabetes ongoing sustainable care and treatment (DOST: A strategy for informational deliverance through visual dynamic modules sustained by near peer mentoring

Directory of Open Access Journals (Sweden)

Ankur Joshi

2016-01-01

Full Text Available Background: The informational continuity for a diabetic patient is of paramount importance. This study on a pilot basis explores the process utility of structured educational modular sessions grounded on the principle of near-peer mentoring. Methodology: Visual modules were prepared for diabetic patients. These modules were instituted to 25 diabetic patients in logical sequences. In the next phase, 4 persons of these 25 patients were designated as diabetic-diabetes ongoing sustainable care and treatment (DOST. Each diabetic-DOST was clubbed with two patients for modular session and informational deliverance during the next 7 days. Process analysis was performed with “proxy-indicators,” namely, monthly glycemic status, knowledge assessment scores, and quality of life. Data were analyzed by interval estimates and through nonparametric analysis. Results: Nonparametric analysis indicated a significant improvement in glycemic status in terms with fasting blood sugar (W = 78 z = 3.04, P = 0.002, 2 h-postprandial blood sugar (W = 54, z = 2.01, P = 0.035, and in knowledge score (c2 = 19.53, df = 3; P = 0.0002. Quality of life score showed significant improvement in 2 out of 7 domains, namely, satisfaction with treatment ([difference in mean score = 1.40 [1.94 to 0.85] and symptom botherness (difference in mean score = 0.98 [1.3–0.65]. Conclusion: Because of inherent methodological limitations and innate biases, at this juncture no conclusive statement can be drawn. Although, primitive process evidences indicate the promising role of the diabetic-DOST strategy.

Deliverable D5: The Multi-Megawatt Target Station (Final Report)

CERN Document Server

Karel Samec et al. (CERN, IPUL, ITN, PSI)

The Eurisol initiative seeks to develop an isotope production facility to provide the scientific community with the means to achieving high yields of isotopes and extending the variety of isotopes thus produced towards more exotic types rarely seen in existing facilities.The Multi-MW converter target at the heart of the projected facility is designed to create isotopes by fissioning uranium carbide (UC) target arranged coaxially around a 4 MW converter target. It is therefore essential that the target be as compact as possible to avoid losing neutrons to capture whilst maximising the neutron flux to enhance the number of fissions per second in the UC targets.The proposed ISOL facility would use both (a) several 100 kW proton beams on a thick solid target to produceRIBs directly, and (b) a liquid metal 4 MW ‘converter’ target to release high fluxes of spallation neutrons which would then produce RIBs by fission in a secondary uranium carbide (UCx) target. An alternative windowless liquid mercury-jet ‘con...

Contribution to the study of low-energy (d,p) reactions on light nuclei; Contribution a l'etude des reactions (d,p) a basse energie sur noyaux legers

Energy Technology Data Exchange (ETDEWEB)

Nguyen Van, S. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1967-05-15

This work is carried out with a view to analysing low energy (d,p) reactions on light nuclei measured at Grenoble or Algiers and suggesting a direct mechanism. The distorted wave approximation has been applied; this requires the development of programmes for the IBM 7044 computer at the 'Institut des Mathematiques Appliquees' in Grenoble. The (d,p) reactions on {sup 14}N, {sup 9}Be, {sup 22}Ne and {sup 16}O are dealt with. A calculation of the interference of the direct interaction and of resonating effects has been applied to {sup 16}O. (author) [French] Ce travail a pour but d'analyser les reactions (d,p) a basse energie sur noyaux legers, mesurees a Grenoble ou a Alger et qui suggerent un mecanisme direct. L'approximation des ondes distordues a ete appliquee, necessitant la mise au point de programmes sur l'ordinateur IBM 7044 de l'Institut des Mathematiques Appliquees de Grenoble. Des reactions (d,p) sur {sup 14}N, {sup 9}Be, {sup 22}Ne et {sup 16}O sont traitees. Un calcul de l'interference de l'interaction directe et des effets resonnants a ete applique a {sup 16}O. (auteur)

Single pion and several pions production in {pi}{sup +}p interactions at 1.6 GeV/c; Creation d'un et plusieurs mesons {pi} dans les interactions {pi}{sup +} p a 1,6 GeV/c

Energy Technology Data Exchange (ETDEWEB)

Jabiol, M A [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

1966-07-01

The production of {rho}{sup +}, N{sub 33}{sup *}, and {eta}{sup 0} was observed in {pi}{sup +}p interactions at 1.6 GeV/c. In the reactions where one pion is created, the comparison between the experimental distribution of the {rho}{sup +} and the N{sub 33}{sup *} with the predictions of the peripheral model modified by absorption effects permits the conclusion that the contribution of this model is important, but that other effects such as interferences between {rho}{sup +} and N{sub 33}{sup *} are not negligible. In the reactions where several pions are created, the branching ratios of some decay modes of {eta}0 are evaluated and the associated production of {eta}{sup 0} and N{sub 33}{sup *} is observed. (author) [French] La production des resonances {rho}{sup +}, N{sub 33}{sup *} et {eta}{sup 0} a ete observee dans les interactions {pi}{sup +}p a 1,6 GeV/c. Dans les reactions ou un seul meson {pi} est cree, la comparaison des distributions experimentales relatives au meson {rho}{sup +} et a l'isobare N{sub 33}{sup *} aux previsions du modele peripherique modifie par les effets d'absorption, permet d'affirmer que la contribution de ce modele est importante, mais que des effets tels que les interferences entre les processus de creation du {rho}{sup +} et de N{sub 33}{sup *} ne sont pas negligeables. Dans les reactions ou plusieurs mesons {pi} sont crees, les rapports de branchement de certains modes de desintegration du meson {eta}{sup 0} ont pu etre evalues et la production associee du {eta}{sup 0} et de N{sub 33}{sup *} a ete observee. (auteur)

Cost benefit analysis vs. referenda

OpenAIRE

Martin J. Osborne; Matthew A. Turner

2007-01-01

We consider a planner who chooses between two possible public policies and ask whether a referendum or a cost benefit analysis leads to higher welfare. We find that a referendum leads to higher welfare than a cost benefit analyses in "common value" environments. Cost benefit analysis is better in "private value" environments.

Parametric amplification and wavelength conversion of a 2.048-Tbit/s WDM PDM 16-QAM signal

DEFF Research Database (Denmark)

Hu, Hao; Jopson, R. M.; Gnauck, A. H.

2014-01-01

We demonstrate polarisation-insensitive parametric amplification in highly nonlinear fibre of a 2.048-Tbit/s dense WDM PDM 16-QAM signal with ∼10 dB on-off gain and simultaneous wavelength conversion and phase conjugation, with mean Q2 penalties of only 0.6 dB and 0.4 dB....

Concept Specifications/Prerequisites for DeepWind Deliverable D8.1

DEFF Research Database (Denmark)

Schmidt Paulsen, Uwe; Schløer, Signe; Larsén, Xiaoli Guo

(NL), NREL(USA), STATOIL(N), VESTAS(DK) and NENUPHAR(F). The report discuss the design considerations for offshore wind turbines, both in general and specifically for Darrieus-type floating turbines, as is the focus of the DeepWind project. The project is considered in a North Sea environment, notably close......The work is a result of the contributions within the DeepWind project which is supported by the European Commission, Grant 256769 FP7 Energy 2010 - Future emerging technologies, and by the DeepWind beneficiaries: DTU(DK), AAU(DK), TUDELFT(NL), TUTRENTO(I), DHI(DK), SINTEF(N), MARINTEK(N), MARIN...

Problems of Journalism; Proceedings of the 1975 Annual Convention of the American Society of Newspaper Editors (Washington, D.C., April 16-18, 1975).

Science.gov (United States)

American Society of Newspaper Editors, Easton, PA.

This document reports the 1975 proceedings of the American Society of Newspaper Editors (ASNE) convention held in Washington, D.C., April 16-18. The contents include a list of officers and directors, past presidents of the society, and a copy of the ASNE Code of Ethics. Also contained in the document are reports on such individual sessions as…

Deliverable D2.4: Status of Dry Electrode Development Activity

NARCIS (Netherlands)

Mihajlovic, V.; Garcia Molina, G.

2010-01-01

The goal of dry electrode development activity within the WP2 is tobuild a dry electrode prototype for brain wave sensing that is comfortable for the user and provides sufficient signal quality. The electrodes are to be utilized in BCI applications, namely Steady-StateVisually Evoked Potential

Summary report of already published guidance on L2 PSA for external hazards, shutdown states, spent fuel storage

International Nuclear Information System (INIS)

Dirksen, Gerben; Sauvage, Estelle

2014-01-01

This report (deliverable D40.2 of the project ASAMPSA-E) proposes a review of the existing guidance with relevance to ASAMPSA-E PSA Level 2 topics (external hazards, shutdown states, spent fuel pool). As a complement of this task, the deliverable D40.2 tries to identify any potential missing guidance for the development of an extended PSA level 2, and any sources of knowledge beyond existing guidance which might help generating extended PSA level 2. Based on this approach the last section provides a summary compilation which identifies possibilities for completing existing guidelines (especially the guidance developed in the previous ASAMPSA2 project) and/or creating new guidelines for extended PSA Level 2. (authors)

Deliverable D4.2. Report on Standards and Regulations Compliance

OpenAIRE

Duzha, Armend; Polemi, Nineta; Gouvas, Panagiotis; Karantjias, Athanasis; Papastergious, Spyros; Patsakis, Constantinos; Douligeris, Christios; Glykos, Stamatios; Exarchou, Georgios

2016-01-01

Despite the importance of Critical Information Infrastructures (CIIs) and dynamic ICT-based maritime supply chains (SCs) for port operations, state-of-the-art Risk Management (RM) methodologies for maritime environments pay limited attention to cyber-security and do not adequately address security processes for international SCs. Motivated by these limitations, MITIGATE will introduce, integrate, validate and commercialize a novel RM system, which will empower stakeholders’ collaboration for ...

Stakeholders´ Requirements and Reference Scenarios. Deliverable D2.1

OpenAIRE

Diamantopoulou, Vasiliki; Mouratidis, Haralambos; Pavlidis, Michalis; Rekleitis, Evangelos

2016-01-01

The present document covers important elements on the development of WP2, including: a literature review of the state of the art relevant to security requirements engineering, risk management and supply chain security management standards. Following, the elicitation, analysis and documentation of requirements associated risk management and cyber-security management in ports and their supply chain sectors is presented. Emphasis is given in capturing the perspectives of all stakeholders; includ...

Deliverable D74.2. Probabilistic analysis methods for support structures

DEFF Research Database (Denmark)

Gintautas, Tomas

2018-01-01

Relevant Description: Report describing the probabilistic analysis for offshore substructures and results attained. This includes comparison with experimental data and with conventional design. Specific targets: 1) Estimate current reliability level of support structures 2) Development of basis...... for probabilistic calculations and evaluation of reliability for offshore support structures (substructures) 3) Development of a probabilistic model for stiffness and strength of soil parameters and for modeling geotechnical load bearing capacity 4) Comparison between probabilistic analysis and deterministic...

16 CFR 240.6 - Interstate commerce.

Science.gov (United States)

2010-01-01

...(d) and 2(e) of the Act. (The commerce standard for sections 2 (d) and (e) is at least as inclusive... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Interstate commerce. 240.6 Section 240.6... ALLOWANCES AND OTHER MERCHANDISING PAYMENTS AND SERVICES § 240.6 Interstate commerce. The term interstate...

Comparison of radiation dose and image quality of Siremobil-IsoC{sup 3D} with a 16-slice spiral CT for diagnosis and intervention in the human pelvic bone; Vergleich von Strahlenexposition und Bildqualitaet eines Siremobil-IsoC{sup 3D} mit einem 16-Zeilen-Spiral-CT bei Diagnostik und Intervention am humanen Becken

Energy Technology Data Exchange (ETDEWEB)

Wieners, G.; Pech, M.; Beck, A.; Wust, P.; Felix, R.; Schroeder, R.J. [Klinik fuer Strahlenheilkunde, Charite, Univ. Berlin (Germany); Koenig, B.; Erdmenger, U.; Stoeckle, U. [Klinik fuer Unfallchirurgie, Charite, Univ. Berlin (Germany)

2005-02-01

Purpose: to compare the image quality of 16-slice computed tomography with the image quality of Siremobil-IsoC{sup 3D} of the pelvic region and to measure simultaneously the radiation dose before and after implantation of a sacroiliac screw (SI-screw) Materials and methods: the pelvic region of 8 human cadavers was examined in the Siremobil-IsoC{sup 3D} at five different levels. We used a standard protocol for the 16-slice CT of the complete pelvic region before and after insertion of a pelvic screw, followed by stepwise reduction of the tube current to find the tube current that equalizes the image quality of both modalities. We controlled the image quality by judging important structures such as neuroforamen, nerves, sacroiliacal joint space, intervertebral space, osteophytes, iliopsoas muscle, acetabular surface, fovea centralis, hip joint and os pubis. The image quality was judged by three radiologists and three trauma surgeons using a ranking from 1 to 5. The dose was measured with an endorectally placed NOMEX Dosimeter, to obtain the gonadal dose. Results: the medium score for all viewers of the Siremobil-IsoC{sup 3D} examinations was between 3 and 4.3. The medium score for all CT-examinations with a tube current of 250 mA was between 1.3 and 2.2. The reduction of tube current down to 80 mA hardly influenced the marks for the analyzed structures. Under 80 mA, bony structures, even after implantation of a SI-screw, were still marked as good, but soft tissue differentiation was getting worse. For the examination of the pelvis, the average dose-length product for the IsoC{sup 3D} was 41.2 mGy x cm. The medium dose-length product for CT was 389 mGy x cm for 250 mA, 125 mGy x cm for 80 mA and 82 mGy x cm for 60 mA. (orig.)

Evaluation of a workplace disability prevention intervention in Canada: examining differing perceptions of stakeholders.

Science.gov (United States)

Maiwald, Karin; de Rijk, Angelique; Guzman, Jaime; Schonstein, Eva; Yassi, Annalee

2011-06-01

INTRODUCTION Workplace disability prevention is important, but stakeholders can differ in their appreciation of such interventions. We present a responsive evaluation of a workplace disability prevention intervention in a Canadian healthcare organization. Three groups of stakeholders were included: designers of the intervention, deliverers, and workers. The aim was to examine the appreciation of this intervention by analyzing the discrepancies with respect to what these various stakeholders see as the causes of work disability, what the intervention should aim at to address this problem, and to what extent the intervention works in practice. METHODS A qualitative research method was used, including data-triangulation: (a) documentary materials; (b) semi-structured interviews with the deliverers and workers (n = 14); (c) participatory observations of group meetings (n = 6); (d) member-checking meetings (n = 3); (e) focus-group meetings (n = 2). A grounded theory approach, including some ethnographic methodology, was used for the data-analysis. RESULTS Stakeholders' perceptions of causes for work disability differ, as do preferred strategies for prevention. Designers proposed work-directed measures to change the workplace and work organizations, and individual-directed measures to change workers' behaviour. Deliverers targeted individual-directed measures, however, workers were mostly seeking work-directed measures. To assess how the intervention was working, designers sought a wide range of outcome measures. Deliverers focused on measurable outcomes targeted at reducing work time-loss. Workers perceived that this intervention offered short-term benefits yet fell short in ensuring sustainable return-to-work. CONCLUSION This study provides understanding of where discrepancies between stakeholders' perceptions about interventions come from. Our findings have implications for workplace disability prevention intervention development, implementation and evaluation

(16) Adebayo and Menkir LAUTECH

African Journals Online (AJOL)

Adeyinka Odunsi

2011-09-16

Sep 16, 2011 ... A Ph.D. thesis,. West Africa Centre for Crop. Improvement (WACCI), University of Ghana, Legon., 216p. Adebayo, M.A., A. Menkir, E. Blay, V. Gracen, E. Danquah and S. Hearne. (2014). Genetic analysis of drought tolerance in adapted x exotic crosses of maize inbred lines under managed stress conditions.

REMOVAL OF DIQUATERNARY AMMONIUM CATIONS FROM AS-SYNTHESIZED SSZ-16 ZEOLITE

Czech Academy of Sciences Publication Activity Database

Supiňková, Taťána; Jirka, Ivan; Drahokoupil, Jan; Langmaier, Jan; Fíla, V.; Brabec, Libor; Kočiřík, Milan

2017-01-01

Roč. 9, č. 2017 (2017), s. 26-31 E-ISSN 2336-5382 R&D Projects: GA ČR(CZ) GA16-02681S Institutional support: RVO:61388955 ; RVO:68378271 Keywords : zeolite * hydrothermal synthesis * SSZ-16 Subject RIV: CF - Physical ; Theoretical Chemistry; BM - Solid Matter Physics ; Magnetism (FZU-D) OBOR OECD: Physical chemistry; Condensed matter physics (including formerly solid state physics, supercond.) (FZU-D)

A 16X16 Discrete Cosine Transform Chip

Science.gov (United States)

Sun, M. T.; Chen, T. C.; Gottlieb, A.; Wu, L.; Liou, M. L.

1987-10-01

Among various transform coding techniques for image compression the Discrete Cosine Transform (DCT) is considered to be the most effective method and has been widely used in the laboratory as well as in the market, place. DCT is computationally intensive. For video application at 14.3 MHz sample rate, a direct implementation of a 16x16 DCT requires a throughput, rate of approximately half a billion multiplications per second. In order to reduce the cost of hardware implementation, a single chip DCT implementation is highly desirable. In this paper, the implementation of a 16x16 DCT chip using a concurrent architecture will be presented. The chip is designed for real-time processing of 14.3 MHz sampled video data. It uses row-column decomposition to implement the two-dimensional transform. Distributed arithmetic combined with hit-serial and hit-parallel structures is used to implement the required vector inner products concurrently. Several schemes are utilized to reduce the size of required memory. The resultant circuit only uses memory, shift registers, and adders. No multipliers are required. It achieves high speed performance with a very regular and efficient integrated circuit realization. The chip accepts 0-bit input and produces 14-bit DCT coefficients. 12 bits are maintained after the first one-dimensional transform. The circuit has been laid out using a 2-μm CMOS technology with a symbolic design tool MULGA. The core contains approximately 73,000 transistors in an area of 7.2 x 7.0

Search for D0-D(-)0 mixing and a measurement of the doubly Cabibbo-suppressed decay rate in D0-->Kpi decays.

Science.gov (United States)

Aubert, B; Barate, R; Boutigny, D; Gaillard, J-M; Hicheur, A; Karyotakis, Y; Lees, J P; Robbe, P; Tisserand, V; Zghiche, A; Palano, A; Pompili, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J; Kerth, L T; Kolomensky, Yu G; Kral, J F; Kukartsev, G; LeClerc, C; Levi, M E; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Romosan, A; Ronan, M T; Shelkov, V G; Telnov, A V; Wenzel, W A; Harrison, T J; Hawkes, C M; Knowles, D J; Penny, R C; Watson, A T; Watson, N K; Deppermann, T; Goetzen, K; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schmuecker, H; Steinke, M; Barlow, N R; Bhimji, W; Boyd, J T; Chevalier, N; Cottingham, W N; Mackay, C; Wilson, F F; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Kyberd, P; McKemey, A K; Blinov, V E; Bukin, A D; Golubev, V B; Ivanchenko, V N; Kravchenko, E A; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Yushkov, A N; Best, D; Chao, M; Kirkby, D; Lankford, A J; Mandelkern, M; McMahon, S; Mommsen, R K; Roethel, W; Stoker, D P; Buchanan, C; Hadavand, H K; Hill, E J; MacFarlane, D B; Paar, H P; Rahatlou, Sh; Schwanke, U; Sharma, V; Berryhill, J W; Campagnari, C; Dahmes, B; Kuznetsova, N; Levy, S L; Long, O; Lu, A; Mazur, M A; Richman, J D; Verkerke, W; Beringer, J; Eisner, A M; Grothe, M; Heusch, C A; Lockman, W S; Schalk, T; Schmitz, R E; Schumm, B A; Seiden, A; Turri, M; Walkowiak, W; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dorsten, M P; Dubois-Felsmann, G P; Dvoretskii, A; Hitlin, D G; Narsky, I; Porter, F C; Ryd, A; Samuel, A; Yang, S; Jayatilleke, S; Mancinelli, G; Meadows, B T; Sokoloff, M D; Barillari, T; Blanc, F; Bloom, P; Clark, P J; Ford, W T; Nauenberg, U; Olivas, A; Rankin, P; Roy, J; Smith, J G; van Hoek, W C; Zhang, L; Harton, J L; Hu, T; Soffer, A; Toki, W H; Wilson, R J; Zhang, J; Altenburg, D; Brandt, T; Brose, J; Colberg, T; Dickopp, M; Dubitzky, R S; Hauke, A; Lacker, H M; Maly, E; Müller-Pfefferkorn, R; Nogowski, R; Otto, S; Schubert, K R; Schwierz, R; Spaan, B; Wilden, L; Bernard, D; Bonneaud, G R; Brochard, F; Cohen-Tanugi, J; Thiebaux, Ch; Vasileiadis, G; Verderi, M; Khan, A; Lavin, D; Muheim, F; Playfer, S; Swain, J E; Tinslay, J; Bozzi, C; Piemontese, L; Sarti, A; Treadwell, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Falciai, D; Finocchiaro, G; Patteri, P; Peruzzi, I M; Piccolo, M; Zallo, A; Buzzo, A; Contri, R; Crosetti, G; Lo Vetere, M; Macri, M; Monge, M R; Passaggio, S; Pastore, F C; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Bailey, S; Morii, M; Grenier, G J; Lee, S-J; Mallik, U; Cochran, J; Crawley, H B; Lamsa, J; Meyer, W T; Prell, S; Rosenberg, E I; Yi, J; Davier, M; Grosdidier, G; Höcker, A; Laplace, S; Le Diberder, F; Lepeltier, V; Lutz, A M; Petersen, T C; Plaszczynski, S; Schune, M H; Tantot, L; Wormser, G; Bionta, R M; Brigljević, V; Cheng, C H; Lange, D J; Wright, D M; Bevan, A J; Fry, J R; Gabathuler, E; Gamet, R; Kay, M; Payne, D J; Sloane, R J; Touramanis, C; Aspinwall, M L; Bowerman, D A; Dauncey, P D; Egede, U; Eschrich, I; Morton, G W; Nash, J A; Sanders, P; Taylor, G P; Back, J J; Bellodi, G; Harrison, P F; Shorthouse, H W; Strother, P; Vidal, P B; Cowan, G; Flaecher, H U; George, S; Green, M G; Kurup, A; Marker, C E; McMahon, T R; Ricciardi, S; Salvatore, F; Vaitsas, G; Winter, M A; Brown, D; Davis, C L; Allison, J; Barlow, R J; Forti, A C; Hart, P A; Jackson, F; Lafferty, G D; Lyon, A J; Weatherall, J H; Williams, J C; Farbin, A; Jawahery, A; Kovalskyi, D; Lae, C K; Lillard, V; Roberts, D A; Blaylock, G; Dallapiccola, C; Flood, K T; Hertzbach, S S; Kofler, R; Koptchev, V B; Moore, T B; Staengle, H; Willocq, S; Cowan, R; Sciolla, G; Taylor, F; Yamamoto, R K; Mangeol, D J J; Milek, M; Patel, P M; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Hast, C; Taras, P; Nicholson, H; Cartaro, C; Cavallo, N; De Nardo, G; Fabozzi, F; Gatto, C; Lista, L; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; LoSecco, J M; Gabriel, T A; Brau, B; Pulliam, T; Brau, J; Frey, R; Iwasaki, M; Potter, C T; Sinev, N B; Strom, D; Torrence, E; Colecchia, F; Dorigo, A; Galeazzi, F; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Tiozzo, G; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; de la Vaissière, Ch; Del Buono, L; Hamon, O; Leruste, Ph; Ocariz, J; Pivk, M; Roos, L; Stark, J; T'Jampens, S; Manfredi, P F; Re, V; Gladney, L; Guo, Q H; Panetta, J; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Bucci, F; Calderini, G; Carpinelli, M; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Martinez-Vidal, F; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Walsh, J; Haire, M; Judd, D; Paick, K; Wagoner, D E; Danielson, N; Elmer, P; Lu, C; Miftakov, V; Olsen, J; Smith, A J S; Varnes, E W; Bellini, F; Cavoto, G; del Re, D; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Leonardi, E; Mazzoni, M A; Morganti, S; Pierini, M; Piredda, G; Safai Tehrani, F; Serra, M; Voena, C; Christ, S; Wagner, G; Waldi, R; Adye, T; De Groot, N; Franek, B; Geddes, N I; Gopal, G P; Olaiya, E O; Xella, S M; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Giraud, P-F; Hamel de Monchenault, G; Kozanecki, W; Langer, M; London, G W; Mayer, B; Schott, G; Vasseur, G; Yeche, Ch; Zito, M; Purohit, M V; Weidemann, A W; Yumiceva, F X; Aston, D; Bartoldus, R; Berger, N; Boyarski, A M; Buchmueller, O L; Convery, M R; Coupal, D P; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Grauges-Pous, E; Hadig, T; Halyo, V; Hryn'ova, T; Innes, W R; Jessop, C P; Kelsey, M H; Kim, P; Kocian, M L; Langenegger, U; Leith, D W G S; Luitz, S; Luth, V; Lynch, H L; Marsiske, H; Menke, S; Messner, R; Muller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Petrak, S; Ratcliff, B N; Robertson, S H; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Simi, G; Snyder, A; Soha, A; Stelzer, J; Su, D; Sullivan, M K; Tanaka, H A; Va'vra, J; Wagner, S R; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wright, D H; Young, C C; Burchat, P R; Meyer, T I; Roat, C; Ahmed, S; Ernst, J A; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Kim, H; Ritchie, J L; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bona, M; Gallo, F; Gamba, D; Borean, C; Bosisio, L; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Poropat, P; Vitale, L; Vuagnin, G; Panvini, R S; Banerjee, Sw; Brown, C M; Fortin, D; Jackson, P D; Kowalewski, R; Roney, J M; Band, H R; Dasu, S; Datta, M; Eichenbaum, A M; Hu, H; Johnson, J R; Liu, R; Lodovico, F Di; Mohapatra, A K; Pan, Y; Prepost, R; Sekula, S J; von Wimmersperg-Toeller, J H; Wu, J; Wu, S L; Yu, Z; Neal, H

2003-10-24

We present results of a search for D0-D(-)0 mixing and a measurement of R(D), the ratio of doubly Cabibbo-suppressed decays to Cabibbo-favored decays, using D0-->K+pi- decays from 57.1 fb(-1) of data collected near sqrt[s]=10.6 GeV with the BABAR detector at the PEP-II collider. At the 95% confidence level, allowing for CP violation, we find the mixing parameters x('2)<0.0022 and -0.05616%. In the limit of no mixing, R(D)=[0.357+/-0.022(stat)+/-0.027(syst)]% and the CP-violating asymmetry A(D)=0.095+/-0.061(stat)+/-0.083(syst).

Overview of 3D Documentation Data and Tools available for Archaeological Researches: case study of the Romanesque Church of Dugny-sur-Meuse (France)

Science.gov (United States)

Macher, H.; Grussenmeyer, P.; Kraemer, C.; Guillemin, S.

2015-08-01

In this paper, the 3D documentation of the full structure of the Romanesque church of Dugny-sur-Meuse is discussed. In 2012 and 2013, a 3D recording project was carried out under the supervision of the Photogrammetry and Geomatics Research Group from INSA Strasbourg (France) in cooperation with C. Kraemer, archaeologist from Nancy (France). The goal of the project was on one hand to propose new solutions and tools to the archaeologists in charge of the project especially for stone by stone measurements. On the other hand, a simplified 3D model was required by the local authorities for communication purposes. To achieve these goals several techniques were applied namely GNSS measurements and accurate traverse networks, photogrammetric recordings and terrestrial laser scanning acquisitions. The various acquired data are presented in this paper. Based on these data, several deliverables are also proposed. The generation of orthoimages from plane as well as cylindrical surfaces is considered. Moreover, the workflow for the creation of a 3D simplified model is also presented.

Overview of 3D Documentation Data and Tools available for Archaeological Researches: case study of the Romanesque Church of Dugny-sur-Meuse (France

Directory of Open Access Journals (Sweden)

H. Macher

2015-08-01

Full Text Available In this paper, the 3D documentation of the full structure of the Romanesque church of Dugny-sur-Meuse is discussed. In 2012 and 2013, a 3D recording project was carried out under the supervision of the Photogrammetry and Geomatics Research Group from INSA Strasbourg (France in cooperation with C. Kraemer, archaeologist from Nancy (France. The goal of the project was on one hand to propose new solutions and tools to the archaeologists in charge of the project especially for stone by stone measurements. On the other hand, a simplified 3D model was required by the local authorities for communication purposes. To achieve these goals several techniques were applied namely GNSS measurements and accurate traverse networks, photogrammetric recordings and terrestrial laser scanning acquisitions. The various acquired data are presented in this paper. Based on these data, several deliverables are also proposed. The generation of orthoimages from plane as well as cylindrical surfaces is considered. Moreover, the workflow for the creation of a 3D simplified model is also presented.

A quality profile and techniques for eCommerce application assessment: D 2 ProducEbility-U

OpenAIRE

Punter, T.; Steffens, P.

2002-01-01

This document presents the deliverables of the Work packages WP2.1 and WP2.2 of the Fraunhofer IESE 2002 internal project ProducEbility-U. It provides the definition of a quality profile for eCommerce applications and an overview of assessment criteria. This chapter provides a characterisation of eCommerce applications, compare the assessment of eCommerce applications with other FhG/IESE-assessments, and motivates the development of quality profile for eCommerce assessment. An eCommerce appli...

A psychometric evaluation of the clinician-rated Quick Inventory of Depressive Symptomatology (QIDS-C16) in patients with bipolar disorder.

Science.gov (United States)

Bernstein, Ira H; Rush, A John; Suppes, Trisha; Trivedi, Madhukar H; Woo, Ada; Kyutoku, Yasushi; Crismon, M Lynn; Dennehy, Ellen; Carmody, Thomas J

2009-06-01

The clinician-rated, 16-item Quick Inventory of Depressive Symptomatology (QIDS-C16) has been extensively evaluated in patients with major depressive disorder (MDD). This report assesses the psychometric properties of the QIDS-C16 in outpatients with bipolar disorder (BD, N = 405) and MDD (N = 547) and in bipolar patients in the depressed phase only (BD-D) (N = 99) enrolled in the Texas Medication Algorithm Project (TMAP) using classical test theory (CTT) and the Samejima graded item response theory (IRT) model. Values of coefficient alpha were very similar in BD, MDD, and BD-D groups at baseline (alpha = 0.80-0.81) and at exit (alpha = 0.82-0.85). The QIDS-C16 was unidimensional for all three groups. MDD and BD-D patients (n = 99) had comparable symptom levels. The BD-D patients (n = 99) had the most, and bipolar patients in the manic phase had the least depressive symptoms at baseline. IRT analyses indicated that the QIDS-C16 was most sensitive to the measurement of depression for both MDD patients and for BD-D patients in the average range. The QIDS-C16 is suitable for use with patients with BD and can be used as an outcome measure in trials enrolling both BD and MDD patients. John Wiley & Sons, Ltd

Release of RANKERN 16A

Directory of Open Access Journals (Sweden)

Bird Adam

2017-01-01

Full Text Available RANKERN 16 is the latest version of the point-kernel gamma radiation transport Monte Carlo code from AMEC Foster Wheeler’s ANSWERS Software Service. RANKERN is well established in the UK shielding community for radiation shielding and dosimetry assessments. Many important developments have been made available to users in this latest release of RANKERN. The existing general 3D geometry capability has been extended to include import of CAD files in the IGES format providing efficient full CAD modelling capability without geometric approximation. Import of tetrahedral mesh and polygon surface formats has also been provided. An efficient voxel geometry type has been added suitable for representing CT data. There have been numerous input syntax enhancements and an extended actinide gamma source library. This paper describes some of the new features and compares the performance of the new geometry capabilities.

Release of RANKERN 16A

Science.gov (United States)

Bird, Adam; Murphy, Christophe; Dobson, Geoff

2017-09-01

RANKERN 16 is the latest version of the point-kernel gamma radiation transport Monte Carlo code from AMEC Foster Wheeler's ANSWERS Software Service. RANKERN is well established in the UK shielding community for radiation shielding and dosimetry assessments. Many important developments have been made available to users in this latest release of RANKERN. The existing general 3D geometry capability has been extended to include import of CAD files in the IGES format providing efficient full CAD modelling capability without geometric approximation. Import of tetrahedral mesh and polygon surface formats has also been provided. An efficient voxel geometry type has been added suitable for representing CT data. There have been numerous input syntax enhancements and an extended actinide gamma source library. This paper describes some of the new features and compares the performance of the new geometry capabilities.

ECO D2.5 Learning analytics requirements and metrics report

NARCIS (Netherlands)

Brouns, Francis; Zorrilla Pantaleón, Marta Elena; Esperanza‎ Álvarez Saiz, Elena; Solana González, Pedro; Cobo Ortega, Ángel; Rocío‎ Rocha Blanco, Eliana; Collantes Viaña, Marta; Rodríguez Hoyo, Carlos; De Lima Silva, Mariana; Marta-Lazo, Carmen; Gabelas Barroso, José Antonio; Arranz, Pilar; García, Luis; Silva, Alejandro; Sáez López, José Manuel; Ventura Expósito, Patricia; Jordano de la Torre, María; María, Felix; Viñuales, Javier

2015-01-01

In MOOCs, learning analytics have to be addressed to the various types of learners that participate. This deliverable describes indicators that enable both teachers and learner to monitor the progress and performance as well as identify whether there are learners at risk of dropping out. How these

MO-B-16A-01: Memorial to Donald D. Tolbert - Memorial Lecture

Energy Technology Data Exchange (ETDEWEB)

Morin, R [Mayo Clinic, Jacksonville, FL (United States)

2014-06-15

The Medical Physics community lost one of its prominent leaders in April, 2013 with the passing of Donald D. Tolbert, PhD. He received his Doctorate at the University of Kansas followed by post Doctoral training at Florida State University and the University of Wisconsin. He was Chief of Radiation Therapy Medical Physics at the University of Wisconsin Hospital for 7 years before relocating to Honolulu Hawaii, where he founded the consulting group Mid-Pacific Medical Physics. Don was a leader in both the AAPM and the ACR, chairing the Professional Council and the Commission on Medical Physics. He was active on the AAPM Board of Directors and a member of the ACR Board of Chancellors. Dr. Tolbert's approach to the difficult problems of the times was admired and respected by colleagues in Medical Physics, Radiation Oncology, and Diagnostic Radiology. He always rose above the heated political rhetoric and led the discussion to higher ground. His wisdom was continually sought to solve complicated problems. Following retirement, he returned to homes in Kansas and Colorado, devoting his time to writing about coping with diabetes and providing support for Seniors in Beloit Kansas. Don is survived by his wife, Mattie, his 3 children and 5 grandchildren. He will be greatly missed.

MO-B-16A-01: Memorial to Donald D. Tolbert - Memorial Lecture

International Nuclear Information System (INIS)

Morin, R

2014-01-01

The Medical Physics community lost one of its prominent leaders in April, 2013 with the passing of Donald D. Tolbert, PhD. He received his Doctorate at the University of Kansas followed by post Doctoral training at Florida State University and the University of Wisconsin. He was Chief of Radiation Therapy Medical Physics at the University of Wisconsin Hospital for 7 years before relocating to Honolulu Hawaii, where he founded the consulting group Mid-Pacific Medical Physics. Don was a leader in both the AAPM and the ACR, chairing the Professional Council and the Commission on Medical Physics. He was active on the AAPM Board of Directors and a member of the ACR Board of Chancellors. Dr. Tolbert's approach to the difficult problems of the times was admired and respected by colleagues in Medical Physics, Radiation Oncology, and Diagnostic Radiology. He always rose above the heated political rhetoric and led the discussion to higher ground. His wisdom was continually sought to solve complicated problems. Following retirement, he returned to homes in Kansas and Colorado, devoting his time to writing about coping with diabetes and providing support for Seniors in Beloit Kansas. Don is survived by his wife, Mattie, his 3 children and 5 grandchildren. He will be greatly missed

Neutron occupancy of the 0d{sub 5/2} orbital and the N=16 shell closure in {sup 24}O

Energy Technology Data Exchange (ETDEWEB)

Tshoo, K., E-mail: tshoo@ibs.re.kr [Rare Isotope Science Project, Institute for Basic Science, Daejeon 305-811 (Korea, Republic of); Satou, Y. [Department of Physics and Astronomy, Seoul National University, Seoul 151-742 (Korea, Republic of); Bertulani, C.A. [Texas A and M University-Commerce, PO Box 3011, Commerce, Texas 75429 (United States); Bhang, H.; Choi, S. [Department of Physics and Astronomy, Seoul National University, Seoul 151-742 (Korea, Republic of); Nakamura, T.; Kondo, Y.; Deguchi, S.; Kawada, Y.; Nakayama, Y.; Tanaka, K.N.; Tanaka, N.; Togano, Y. [Department of Physics, Tokyo Institute of Technology, Tokyo 152-8551 (Japan); Kobayashi, N. [Department of Physics, University of Tokyo, Tokyo 113-0033 (Japan); Aoi, N. [Research Center for Nuclear Physics, Osaka University, Osaka 567-0047 (Japan); Ishihara, M.; Motobayashi, T.; Otsu, H.; Sakurai, H.; Takeuchi, S. [RIKEN Nishina Center, Saitama 351-0198 (Japan); and others

2014-12-12

One-neutron knockout from {sup 24}O leading to the first excited state in {sup 23}O has been measured for a proton target at a beam energy of 62 MeV/nucleon. The decay energy spectrum of the neutron unbound state of {sup 23}O was reconstructed from the measured four momenta of the {sup 22}O fragment and emitted neutron. A sharp peak was found at E{sub decay}=50±3 keV, corresponding to an excited state in {sup 23}O at 2.78±0.11 MeV, as observed in previous measurements. The longitudinal momentum distribution for this state was consistent with d-wave neutron knockout, providing support for a J{sup π} assignment of 5/2{sup +}. The associated spectroscopic factor was deduced to be C{sup 2}S(0d{sub 5/2})=4.1±0.4 by comparing the measured cross section (σ{sub −1n}{sup exp}=61±6 mb) with a distorted wave impulse approximation calculation. Such a large occupancy for the neutron 0d{sub 5/2} orbital is in line with the N=16 shell closure in {sup 24}O.

Mitigate the impact of transmitter finite extinction ratio using K-means clustering algorithm for 16QAM signal

Science.gov (United States)

Yu, Miao; Li, Yan; Shu, Tong; Zhang, Yifan; Hong, Xiaobin; Qiu, Jifang; Zuo, Yong; Guo, Hongxiang; Li, Wei; Wu, Jian

2018-02-01

A method of recognizing 16QAM signal based on k-means clustering algorithm is proposed to mitigate the impact of transmitter finite extinction ratio. There are pilot symbols with 0.39% overhead assigned to be regarded as initial centroids of k-means clustering algorithm. Simulation result in 10 GBaud 16QAM system shows that the proposed method obtains higher precision of identification compared with traditional decision method for finite ER and IQ mismatch. Specially, the proposed method improves the required OSNR by 5.5 dB, 4.5 dB, 4 dB and 3 dB at FEC limit with ER= 12 dB, 16 dB, 20 dB and 24 dB, respectively, and the acceptable bias error and IQ mismatch range is widened by 767% and 360% with ER =16 dB, respectively.

Teachers' Views of Inclusion: "I'd Rather Pump Gas."

Science.gov (United States)

Vaughn, Sharon; And Others

The issue of inclusion has been at the forefront of attention in education, and has been widely discussed and debated. Since teachers will be the primary service deliverers of whatever inclusion practices are adopted, this study was conducted in an attempt better to understand teachers' understanding and perceptions of inclusion. Focus group…

Vimentin Modulates Infectious Internalization of Human Papillomavirus 16 Pseudovirions.

Science.gov (United States)

Schäfer, Georgia; Graham, Lisa M; Lang, Dirk M; Blumenthal, Melissa J; Bergant Marušič, Martina; Katz, Arieh A

2017-08-15

Human papillomavirus (HPV) infection is the most common viral infection of the reproductive tract, with virtually all cases of cervical cancer being attributable to infection by oncogenic HPVs. However, the exact mechanism and receptors used by HPV to infect epithelial cells are controversial. The current entry model suggests that HPV initially attaches to heparan sulfate proteoglycans (HSPGs) at the cell surface, followed by conformational changes, cleavage by furin convertase, and subsequent transfer of the virus to an as-yet-unidentified high-affinity receptor. In line with this model, we established an in vitro infection system using the HSPG-deficient cell line pgsD677 together with HPV16 pseudovirions (HPV16-PsVs). While pgsD677 cells were nonpermissive for untreated HPV16-PsVs, furin cleavage of the particles led to a substantial increase in infection. Biochemical pulldown assays followed by mass spectrometry analysis showed that furin-precleaved HPV16-PsVs specifically interacted with surface-expressed vimentin on pgsD677 cells. We further demonstrated that both furin-precleaved and uncleaved HPV16-PsVs colocalized with surface-expressed vimentin on pgsD677, HeLa, HaCaT, and NIKS cells, while binding of incoming viral particles to soluble vimentin protein before infection led to a substantial decrease in viral uptake. Interestingly, decreasing cell surface vimentin by small interfering RNA (siRNA) knockdown in HeLa and NIKS cells significantly increased HPV16-PsV infectious internalization, while overexpression of vimentin had the opposite effect. The identification of vimentin as an HPV restriction factor enhances our understanding of the initial steps of HPV-host interaction and may lay the basis for the design of novel antiviral drugs preventing HPV internalization into epithelial cells. IMPORTANCE Despite HPV being a highly prevalent sexually transmitted virus causing significant disease burden worldwide, particularly cancer of the cervix, cell surface

Doppler lidar mounted on a wind turbine nacelle - UPWIND deliverable D6.7.1

Energy Technology Data Exchange (ETDEWEB)

Angelou, N.; Mann, J.; Courtney, M.; Sjoeholm, M.

2010-12-15

A ZephIR prototype wind lidar manufactured by QinetiQ was mounted on the nacelle of a Vestas V27 wind turbine and measurements of the incoming wind flow towards the rotor of the wind turbine were acquired for approximately 3 months (April - June 2009). The objective of this experiment was the investigation of the turbulence attenuation induced in the lidar measurements. In this report are presented results from data analysis over a 21-hour period (2009-05-05 12:00 - 2009-05-06 09:00). During this period the wind turbine was not operating and the line-of-sight of the lidar was aligned with the wind direction. The analysis included a correlation study between the ZephIR lidar and a METEK sonic anemometer. The correlation analysis was performed using both 10 minutes and 10 Hz wind speed values. The spectral transfer function which describes the turbulence attenuation, which is induced in the lidar measurements, was estimated by means of spectral analysis. An attempt to increase the resolution of the wind speed measurements of a cw lidar was performed, through the deconvolution of the lidar signal. A theoretical model of such a procedure is presented in this report. A simulation has validated the capability of the algorithm to deconvolve and consequently increase the resolution of the lidar system. However the proposed method was not efficient when applied to real lidar wind speed measurements, probably due to the effect, that the wind direction fluctuations along the lidar's line-of-sight have, on the lidar measurements. (Author)

Sampling system for fast single pulses; Realisation d'un dispositif d'echantillonnage d'un signal bref unique

Energy Technology Data Exchange (ETDEWEB)

Zenatti, D. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1969-07-01

Development of a device for the enlargement of the domain of application of classical oscilloscopes to the observation of fast single pulses by application of the sampling principle. Its principal characteristics are: Bandwidth of 700 MHz; Maximum sensibility of 50 mV; Maximum amplitude of input signal of {+-} 1 V; Number of samples of 16; Samples separation of 0,2 ns. (author) [French] Realisation d'un dispositif permettant d'elargir le domaine d'utilisation des oscilloscopes classiques en appliquant le principe de l'echantillonnage a l'observation d'un signal bref unique. Les principales caracteristiques sont les suivantes: Bande passante de 700 MHz; Sensibilite maximale de 50 mV; Amplitude maximale du signal a echantillonner de {+-} 1 V; Nombre de points d'echantillonnage de 16; Pas d'echantillonnage de 0,2 ns. (auteur)

Single pion and several pions production in {pi}{sup +}p interactions at 1.6 GeV/c; Creation d'un et plusieurs mesons {pi} dans les interactions {pi}{sup +} p a 1,6 GeV/c

Energy Technology Data Exchange (ETDEWEB)

Jabiol, M.A. [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

1966-07-01

The production of {rho}{sup +}, N{sub 33}{sup *}, and {eta}{sup 0} was observed in {pi}{sup +}p interactions at 1.6 GeV/c. In the reactions where one pion is created, the comparison between the experimental distribution of the {rho}{sup +} and the N{sub 33}{sup *} with the predictions of the peripheral model modified by absorption effects permits the conclusion that the contribution of this model is important, but that other effects such as interferences between {rho}{sup +} and N{sub 33}{sup *} are not negligible. In the reactions where several pions are created, the branching ratios of some decay modes of {eta}0 are evaluated and the associated production of {eta}{sup 0} and N{sub 33}{sup *} is observed. (author) [French] La production des resonances {rho}{sup +}, N{sub 33}{sup *} et {eta}{sup 0} a ete observee dans les interactions {pi}{sup +}p a 1,6 GeV/c. Dans les reactions ou un seul meson {pi} est cree, la comparaison des distributions experimentales relatives au meson {rho}{sup +} et a l'isobare N{sub 33}{sup *} aux previsions du modele peripherique modifie par les effets d'absorption, permet d'affirmer que la contribution de ce modele est importante, mais que des effets tels que les interferences entre les processus de creation du {rho}{sup +} et de N{sub 33}{sup *} ne sont pas negligeables. Dans les reactions ou plusieurs mesons {pi} sont crees, les rapports de branchement de certains modes de desintegration du meson {eta}{sup 0} ont pu etre evalues et la production associee du {eta}{sup 0} et de N{sub 33}{sup *} a ete observee. (auteur)

A fast, accurate, and automatic 2D-3D image registration for image-guided cranial radiosurgery

International Nuclear Information System (INIS)

Fu Dongshan; Kuduvalli, Gopinath

2008-01-01

The authors developed a fast and accurate two-dimensional (2D)-three-dimensional (3D) image registration method to perform precise initial patient setup and frequent detection and correction for patient movement during image-guided cranial radiosurgery treatment. In this method, an approximate geometric relationship is first established to decompose a 3D rigid transformation in the 3D patient coordinate into in-plane transformations and out-of-plane rotations in two orthogonal 2D projections. Digitally reconstructed radiographs are generated offline from a preoperative computed tomography volume prior to treatment and used as the reference for patient position. A multiphase framework is designed to register the digitally reconstructed radiographs with the x-ray images periodically acquired during patient setup and treatment. The registration in each projection is performed independently; the results in the two projections are then combined and converted to a 3D rigid transformation by 2D-3D geometric backprojection. The in-plane transformation and the out-of-plane rotation are estimated using different search methods, including multiresolution matching, steepest descent minimization, and one-dimensional search. Two similarity measures, optimized pattern intensity and sum of squared difference, are applied at different registration phases to optimize accuracy and computation speed. Various experiments on an anthropomorphic head-and-neck phantom showed that, using fiducial registration as a gold standard, the registration errors were 0.33±0.16 mm (s.d.) in overall translation and 0.29 deg. ±0.11 deg. (s.d.) in overall rotation. The total targeting errors were 0.34±0.16 mm (s.d.), 0.40±0.2 mm (s.d.), and 0.51±0.26 mm (s.d.) for the targets at the distances of 2, 6, and 10 cm from the rotation center, respectively. The computation time was less than 3 s on a computer with an Intel Pentium 3.0 GHz dual processor

Promotion of European coal to liquids R&D activities

Energy Technology Data Exchange (ETDEWEB)

NONE

2009-06-15

The IEA Clean Coal Centre, with its partners Fuel Consult GmbH (Germany), Glowny Instytut Gornictwa (Poland), Tallinn University of Technology (Estonia) and Stredisko Pro Efektivni Vyuzivani Energie O.P.S. (Czech Republic) is undertaking a promotion and dissemination project. This is supported with a financial grant from the Research Programme of the Research Fund for Coal and Steel under contract number RFC2-CT-2008-00006. The aim is to undertake an overall assessment of the competitiveness and environmental performance of coal to liquids technology from a European perspective. The major deliverable is this report, which comprises a review of CTL activities, worldwide and a consideration of possible future CTL R, D & D needs for Europe, building both on the global state of the art arising from work undertaken previously and the current worldwide activities including the planned and ongoing demonstration programmes in the USA and China respectively. This is complemented with comment on the capabilities and expertise in EU universities as well as EU industry should there be a need to implement larger-scale development and demonstration programmes and ultimately to build large CTL plant. Finally the benefits of seeking international cooperation on CTL R, D & D with stakeholders outside of Europe rather than limiting activities to EU member states is discussed. The information is being promoted and disseminated to all European stakeholders, in particular to those major coal- and oil shale-using member states, Poland, the Czech Republic and Estonia, in which there is significant potential for an uptake of CTL technology and where industry is now starting to reconsider the development of CTL processes.

D5.2 Project web environment

OpenAIRE

Fernie, Kate; Usher, Carol

2011-01-01

This deliverable presents a snapshot of the project web environment in July 2011. The project website http://www.digcur-education.org/eng was launched in month one of the project. The aim of this site is to provide information about the project to stakeholders and to related projects, as well as provide an Intranet for members of the project consortium. The website includes a ‘Join Us’ page to encourage interested parties to register as members of the DigCurV network, to receive the p...

Knockdown of TMEM16A suppressed MAPK and inhibited cell proliferation and migration in hepatocellular carcinoma

Directory of Open Access Journals (Sweden)

Deng L

2016-01-01

Full Text Available Liang Deng,1,* Jihong Yang,2,* Hongwu Chen,3 Bo Ma,4 Kangming Pan,1 Caikun Su,1 Fengfeng Xu,1 Jihong Zhang1 1Department of Hepatobiliary Surgery, The Eastern Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 2Department of General Surgery, The Affiliated Hospital of Hebei University, Baoding, 3Department of Emergency, 4Department of Gastroenterology, The Eastern Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China*These authors contributed equally to this workAbstract: TMEM16A plays an important role in cell proliferation in various cancers. However, less was known about the expression and role of TMEM16A in hepatocellular carcinoma. We screened the expression of TMEM16A in patients’ hepatocellular carcinoma tissues, and also analyzed the biological function of hepatocellular carcinoma cells by knockdown of TMEM16A, as well as the expression of MAPK signaling proteins, including p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and cell cycle regulatory protein cyclin D1 in TMEM16A siRNA-transfected SMMC-7721 cells by Western blot. Our results showed that TMEM16A was overexpressed in hepatocellular carcinoma tissues. Inhibition of TMEM16A suppressed the cell proliferation, migration, and invasion, and cell cycle progression but did not influence the cell apoptosis. TMEM16A siRNA-suppressed cancer cell proliferation and tumor growth were accompanied by a reduction of p38 and ERK1/2 activation and cyclin D1 induction, and were not influenced by other tested MAPK signaling proteins. In addition, inhibition of TMEM16A suppressed tumorigenicity in vivo. TMEM16A is overexpressed in hepatocellular carcinoma, and that inhibition of TMEM16A suppressed MAPK and growth of hepatocellular carcinoma. TMEM16A could be a potentially novel therapeutic target for human cancers, including hepatocellular carcinoma.Keywords: TMEM16A, cell cycle, proliferation, apoptosis

DRDC Power and Energy S and T Option Analysis and Recommendations: A Response to Cross-Cutting Client S and T Requirements

Science.gov (United States)

2015-05-01

Fuel 13% Diesel 8% Gasoline 3% Electricity 16% Natural Gas 9% Light Heating Oil 3% Heavy Heating Oil 2% Aviation Fuel 46% DRDC-RDDC-2015-R068...Support. Force Generation and Support Program deliverables:  Efficiency of engines , structures, lighting, etc. will be improved, alternate...with the aim of achieving greater operational energy efficiencies while maintaining, or improving, existing DND/CAF capabilities. The option

Dual-polarization wavelength conversion of 16-QAM signals in a single silicon waveguide with a lateral p-i-n diode [Invited

DEFF Research Database (Denmark)

Da Ros, Francesco; Gajda, Andrzej; Liebig, Erik

2018-01-01

with an optical signal-to-noise ratio penalty below 0.7 dB. High-quality converted signals are generated thanks to the low polarization dependence (≤0.5 dB) and the high conversion efficiency (CE) achievable. The strong Kerr nonlinearity in silicon and the decrease of detrimental free-carrier absorption due......A polarization-diversity loop with a silicon waveguide with a lateral p-i-n diode as a nonlinear medium is used to realize polarization insensitive four-wave mixing. Wavelength conversion of seven dual-polarization 16-quadrature amplitude modulation (QAM) signals at 16 GBd is demonstrated...

ASASSN-16dt and ASASSN-16hg: Promising candidate period bouncers

Science.gov (United States)

Kimura, Mariko; Isogai, Keisuke; Kato, Taichi; Taguchi, Kenta; Wakamatsu, Yasuyuki; Hambsch, Franz-Josef; Monard, Berto; Myers, Gordon; Dvorak, Shawn; Starr, Peter; Brincat, Stephen M.; de Miguel, Enrique; Ulowetz, Joseph; Itoh, Hiroshi; Stone, Geoff; Nogami, Daisaku

2018-04-01

We present optical photometry of superoutbursts that occurred in 2016 of two WZ Sge-type dwarf novae (DNe), ASASSN-16dt and ASASSN-16hg. Their light curves showed a dip in brightness between the first plateau stage with no ordinary superhumps (or early superhumps) and the second plateau stage with ordinary superhumps. We find that the dip is produced by the slow evolution of the 3 : 1 resonance tidal instability and that it would likely be observed in low mass-ratio objects. An estimated mass ratio (q ≡ M2/M1) from the period of developing (stage A) superhumps [0.06420(3) d] was 0.036(2) in ASASSN-16dt. Additionally, its superoutburst has many properties similar to those in other low-q WZ Sge-type DNe: long-lasting stage-A superhumps, small superhump amplitudes, long delay of ordinary-superhump appearances, and a slow decline rate in the plateau stage with superhumps. Its very small mass ratio and observational characteristics suggest that this system is one of the best candidates for a period bouncer—a binary accounting for the missing population of post-period minimum cataclysmic variables. Although it is not clearly verified due to the lack of detection of stage-A superhumps, ASASSN-16hg might be a possible candidate for period bouncers on the basis of the morphology of its light curves and the small superhump amplitudes. Many outburst properties of period bouncer candidates would originate from the small tidal effects of their secondary stars.

Expression of the p16{sup INK4a} tumor suppressor gene in rodent lung tumors

Energy Technology Data Exchange (ETDEWEB)

Swafford, D.S.; Tesfaigzi, J.; Belinsky, S.A.

1995-12-01

Aberrations on the short arm of chromosome 9 are among the earliest genetic changes in human cancer. p16{sup INK4a} is a candidate tumor suppressor gene that lies within human 9p21, a chromosome region associated with frequent loss of heterozygosity in human lung tumors. The p16{sup INK4a} protein functions as an inhibitor of cyclin D{sub 1}-dependent kinases that phosphorylate the retinoblastoma (Rb) tumor suppressor gene product enabling cell-cycle progression. Thus, overexpression of cyclin D{sub 1}, mutation of cyclin-dependent kinase genes, or loss of p16{sup INK4a} function, can all result in functional inactivation of Rb. Inactivation of Rb by mutation or deletion can result in an increase in p16{sup INK4a} transcription, suggesting that an increased p16{sup INK4a} expression in a tumor cell signals dysfunction of the pathway. The p16{sup (INK4a)} gene, unlike some tumor suppressor genes, is rarely inactivated by mutation. Instead, the expression of this gene is suppressed in some human cancers by hypermethylation of the CpG island within the first exon or by homozygous deletion: 686. Chromosome losses have been observed at 9p21 syntenic loci in tumors of the mouse and rat, two species often used as animal models for pulmonary carcinogenesis. Expression of p16{sup INK4a} is lost in some mouse tumor cell lines, often due to homozygous deletion. These observations indicate that p16{sup INK4a} dysfunction may play a role in the development of neoplasia in rodents as well as humans. The purpose of the current investigation was to define the extent to which p16{sup INK4a} dysfunction contributes to the development of rodent lung tumors and to determine the mechanism of inactivation of the gene. There is no evidence to suggest a loss of function of the p16{sup INK4a} tumor suppressor gene in these primary murine lung tumors by mutation, deletion, or methylation.

SiteChar. Characterisation of European CO2 storage. Deliverable 8.4. Quantitative social site characterisations

Energy Technology Data Exchange (ETDEWEB)

Brunsting, S.; Mastop, E.A. [ECN Policy Studies, Energy research Centre of the Netherlands ECN, Amsterdam (Netherlands); Kaiser, M.; Zimmer, R. [Unabhaengiges Institut fuer Umweltfragen UfU, Berlin (Germany)

2013-06-15

This report describes the results of the last stage of the in-depth social site characterisation activities at two prospective CCS sites as part of the SiteChar project: a CCS onshore site and a CCS offshore site. The onshore site is the Zalecze and Zuchlow site application (Poland - WP5) and the offshore site is the North Sea Moray Firth site (UK - WP3). This deliverable describes the results from a repeated quantitative measurement of local awareness, knowledge, and perceptions of CCS at both sites using representative surveys. For comparison and discussion of all SiteChar WP8 results we refer to the final summary report D8.5. The 2nd survey showed some interesting results. First of all, awareness of CCS was still very low. While in the UK around half of the respondents had at least heard of local plans for CCS, in Poland this was only 21%. It seems that awareness in the UK was mostly induced by specific plans in the area that were abandoned in the course of the SiteChar project. Second, it seems that on the whole the local publics were rather positive about CCS. Most respondents expected a positive impact of CCS on the region. In the UK, arguments for that were mainly economic, while in Poland arguments were mainly related to environmental concerns. Although there are some worries about risks of leakage, especially at the onshore site in Poland, people think that authorities will properly regulate CCS and monitor the safety of CCS. Expectations were mostly that it would be good for the country and that it will help reach international targets for CO2 reduction and buy time to develop renewable energy. Respondents seemed uncertain about the costs of using CCS and whether the technique is ready for widespread use. Especially in Poland people seemed to agree that CCS is essential for tackling climate change. Most differences between the two sites may be attributed to the proximity of the site to the local community. The Polish site is onshore and therefore much

Unexpected Behavior of Enaminones: Interesting New Routes to 1,6-Naphthyridines, 2-Oxopyrrolidines and Pyrano[4,3,2-de][1,6]naphthyridines

Directory of Open Access Journals (Sweden)

Herbert Meier

2012-12-01

Full Text Available Reaction of enaminones 1a–d with 2-aminoprop-1-ene-1,1,3-tricarbonitrile (2 in the presence of AcOH/NH4OAc afforded 7-amino-5-oxo-5,6-dihydro-1,6-naphthyridine-8-carbonitrile derivatives 9a–d. On the other hand, 2-aminopyrano[4,3,2-de] [1,6]naphthyridine-3-carbonitriles 20a–c,e were the only obtained products from the reactions of 1a–d with 2 in the presence of AcOH/NaOAc, while 1d afforded [3,5-bis-(4-chloro-benzoyl-phenyl]-(4-chloro-phenyl-methanone 21 under the same condition. The reaction of 2 with diethyl acetylenedicarboxylate in the presence of AcOH/NH4OAc afforded (4-cyano-5-dicyanomethylene-2-oxo-2,5-dihydro-1H-pyrrol-3-yl-acetic acid ethyl ester 15B.

A Systems Analysis and Design Case Study for a Business Modeling Learning Experience for a Capstone CIS/IS Systems Development Class

Science.gov (United States)

Russell, Jack; Russell, Barbara

2015-01-01

The goal is to provide a robust and challenging problem statement for a capstone, advanced systems analysis and design course for CIS/MIS/CS majors. In addition to the problem narrative, a representative solution for much of the business modeling deliverables is presented using the UML paradigm. A structured analysis deliverable will be the topic…

Software R&D for Next Generation of HEP Experiments, Inspired by Theano

CERN Multimedia

CERN. Geneva

2015-01-01

In the next decade, the frontiers of High Energy Physics (HEP) will be explored by three machines: the High Luminosity Large Hadron Collider (HL-LHC) in Europe, the Long Base Neutrino Facility (LBNF) in the US, and the International Linear Collider (ILC) in Japan. These next generation experiments must address two fundamental problems in the current generation of HEP experimental software: the inability to take advantage and adapt to the rapidly evolving processor landscape, and the difficulty in developing and maintaining increasingly complex software systems by physicists. I will propose a strategy, inspired by the automatic optimization and code generation in Theano, to simultaneously address both problems. I will describe three R&D projects with short-term physics deliverables aimed at developing this strategy. The first project is to develop maximally sensitive General Search for New Physics at the LHC by applying the Matrix Element Method running GPUs of HPCs. The second is to classify and reconstru...

Drug: D03771 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available D03771 Drug Diaveridine (USAN/INN) ... C13H16N4O2 D03771.gif ... Antiparasitic ... DG01932 ... Antifolate, antiprotoz...oal ... Veterinary medicine dihydrofolate reductase [KO:K13998] ... CAS: 5355-16-8 Pub

A little fairness may induce a lot of redistribution in democracy

DEFF Research Database (Denmark)

Tyran, Jean-Robert; Sausgruber, Rupert

2006-01-01

We use a model of self-centered inequality aversion suggested by Fehr and Schmidt (Quart. J. Econom. 114 (3) (1999) 817) to study voting on redistribution. We theoretically identify two classes of conditions when an empirically plausible amount of fairness preferences induces redistribution throu...... referenda. We test the predictions of the adapted inequality aversion model in a simple redistribution experiment and find that it predicts voting outcomes far better than the standard model of voting assuming rationality and strict self-interest...

Report on farm scale eco-efficiency of mitigation and adaption options. D10.3

DEFF Research Database (Denmark)

Kristensen, Ib Sillebak; Olesen, Jørgen Eivind; Hutchings, Nicholas John

2015-01-01

This deliverable collates the information on simulated effects of mitigation and adaptation options at the farm scale in Europe, primarily using the FarmAC model for the mitigation options, and applying semi quantitative modelling for the adaptation options....

Report on the model developments in the sectoral assessments

DEFF Research Database (Denmark)

Iglesias, Ana; Termansen, Mette; Bouwer, Laurens

2014-01-01

into the economic assessments. At the same time, the models will link to the case studies in two ways. First, they use the data in the case studies for model validation and then they provide information to inform stakeholders on adaptation strategies. Therefore, Deliverable 3.2 aims to address three main questions......The Objective of this Deliverable D3.2 is to describe the models developed in BASE that is, the experimental setup for the sectoral modelling. The model development described in this deliverable will then be implemented in the adaptation and economic analysis in WP6 in order to integrate adaptation......: How to address climate adaptation options with the sectoral bottom-up models? - This includes a quantification of the costs of adaptation with the sectoral models, in monetary terms or in other measures of costs. The benefits in this framework will be the avoided damages, therefore a measure...