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Sample records for reference tissue parametric

  1. SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods.

    Science.gov (United States)

    Schuitemaker, Alie; van Berckel, Bart N M; Kropholler, Marc A; Veltman, Dick J; Scheltens, Philip; Jonker, Cees; Lammertsma, Adriaan A; Boellaard, Ronald

    2007-05-01

    (R)-[11C]PK11195 has been used for quantifying cerebral microglial activation in vivo. In previous studies, both plasma input and reference tissue methods have been used, usually in combination with a region of interest (ROI) approach. Definition of ROIs, however, can be labourious and prone to interobserver variation. In addition, results are only obtained for predefined areas and (unexpected) signals in undefined areas may be missed. On the other hand, standard pharmacokinetic models are too sensitive to noise to calculate (R)-[11C]PK11195 binding on a voxel-by-voxel basis. Linearised versions of both plasma input and reference tissue models have been described, and these are more suitable for parametric imaging. The purpose of this study was to compare the performance of these plasma input and reference tissue parametric methods on the outcome of statistical parametric mapping (SPM) analysis of (R)-[11C]PK11195 binding. Dynamic (R)-[11C]PK11195 PET scans with arterial blood sampling were performed in 7 younger and 11 elderly healthy subjects. Parametric images of volume of distribution (Vd) and binding potential (BP) were generated using linearised versions of plasma input (Logan) and reference tissue (Reference Parametric Mapping) models. Images were compared at the group level using SPM with a two-sample t-test per voxel, both with and without proportional scaling. Parametric BP images without scaling provided the most sensitive framework for determining differences in (R)-[11C]PK11195 binding between younger and elderly subjects. Vd images could only demonstrate differences in (R)-[11C]PK11195 binding when analysed with proportional scaling due to intersubject variation in K1/k2 (blood-brain barrier transport and non-specific binding).

  2. SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods

    NARCIS (Netherlands)

    Schuitemaker, Alie; van Berckel, Bart N. M.; Kropholler, Marc A.; Veltman, Dick J.; Scheltens, Philip; Jonker, Cees; Lammertsma, Adriaan A.; Boellaard, Ronald

    2007-01-01

    (R)-[11C]PK11195 has been used for quantifying cerebral microglial activation in vivo. In previous studies, both plasma input and reference tissue methods have been used, usually in combination with a region of interest (ROI) approach. Definition of ROIs, however, can be labourious and prone to

  3. The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues

    International Nuclear Information System (INIS)

    Gabriel, S.; Lau, R.W.; Gabriel, C.

    1996-01-01

    A parametric model was developed to describe the variation of dielectric properties of tissues as a function of frequency. The experimental spectrum from 10 Hz to 100 GHz was modelled with four dispersion regions. The development of the model was based on recently acquired data, complemented by data surveyed from the literature. The purpose is to enable the prediction of dielectric data that are in line with those contained in the vast body of literature on the subject. The analysis was carried out on a Microsoft Excel spreadsheet. Parameters are given for 17 tissue types. (author)

  4. The Absolute Stability Analysis in Fuzzy Control Systems with Parametric Uncertainties and Reference Inputs

    Science.gov (United States)

    Wu, Bing-Fei; Ma, Li-Shan; Perng, Jau-Woei

    This study analyzes the absolute stability in P and PD type fuzzy logic control systems with both certain and uncertain linear plants. Stability analysis includes the reference input, actuator gain and interval plant parameters. For certain linear plants, the stability (i.e. the stable equilibriums of error) in P and PD types is analyzed with the Popov or linearization methods under various reference inputs and actuator gains. The steady state errors of fuzzy control systems are also addressed in the parameter plane. The parametric robust Popov criterion for parametric absolute stability based on Lur'e systems is also applied to the stability analysis of P type fuzzy control systems with uncertain plants. The PD type fuzzy logic controller in our approach is a single-input fuzzy logic controller and is transformed into the P type for analysis. In our work, the absolute stability analysis of fuzzy control systems is given with respect to a non-zero reference input and an uncertain linear plant with the parametric robust Popov criterion unlike previous works. Moreover, a fuzzy current controlled RC circuit is designed with PSPICE models. Both numerical and PSPICE simulations are provided to verify the analytical results. Furthermore, the oscillation mechanism in fuzzy control systems is specified with various equilibrium points of view in the simulation example. Finally, the comparisons are also given to show the effectiveness of the analysis method.

  5. Reference Gene Screening for Analyzing Gene Expression Across Goat Tissue

    Directory of Open Access Journals (Sweden)

    Yu Zhang

    2013-12-01

    Full Text Available Real-time quantitative PCR (qRT-PCR is one of the important methods for investigating the changes in mRNA expression levels in cells and tissues. Selection of the proper reference genes is very important when calibrating the results of real-time quantitative PCR. Studies on the selection of reference genes in goat tissues are limited, despite the economic importance of their meat and dairy products. We used real-time quantitative PCR to detect the expression levels of eight reference gene candidates (18S, TBP, HMBS, YWHAZ, ACTB, HPRT1, GAPDH and EEF1A2 in ten tissues types sourced from Boer goats. The optimal reference gene combination was selected according to the results determined by geNorm, NormFinder and Bestkeeper software packages. The analyses showed that tissue is an important variability factor in genes expression stability. When all tissues were considered, 18S, TBP and HMBS is the optimal reference combination for calibrating quantitative PCR analysis of gene expression from goat tissues. Dividing data set by tissues, ACTB was the most stable in stomach, small intestine and ovary, 18S in heart and spleen, HMBS in uterus and lung, TBP in liver, HPRT1 in kidney and GAPDH in muscle. Overall, this study provided valuable information about the goat reference genes that can be used in order to perform a proper normalisation when relative quantification by qRT-PCR studies is undertaken.

  6. A non-parametric conditional bivariate reference region with an application to height/weight measurements on normal girls

    DEFF Research Database (Denmark)

    Petersen, Jørgen Holm

    2009-01-01

    A conceptually simple two-dimensional conditional reference curve is described. The curve gives a decision basis for determining whether a bivariate response from an individual is "normal" or "abnormal" when taking into account that a third (conditioning) variable may influence the bivariate...... response. The reference curve is not only characterized analytically but also by geometric properties that are easily communicated to medical doctors - the users of such curves. The reference curve estimator is completely non-parametric, so no distributional assumptions are needed about the two......-dimensional response. An example that will serve to motivate and illustrate the reference is the study of the height/weight distribution of 7-8-year-old Danish school girls born in 1930, 1950, or 1970....

  7. Suitable reference tissues for quantitative susceptibility mapping of the brain.

    Science.gov (United States)

    Straub, Sina; Schneider, Till M; Emmerich, Julian; Freitag, Martin T; Ziener, Christian H; Schlemmer, Heinz-Peter; Ladd, Mark E; Laun, Frederik B

    2017-07-01

    Since quantitative susceptibility mapping (QSM) quantifies magnetic susceptibility relative to a reference value, a suitable reference tissue has to be available to compare different subjects and stages of disease. To find such a suitable reference tissue for QSM of the brain, melanoma patients with and without brain metastases were measured. Twelve reference regions were chosen and assessed for stability of susceptibility values with respect to multiple intra-individual and inter-individual measurements, age, and stage of disease. Cerebrospinal fluid (CSF), the internal capsule and one region in the splenium of the corpus callosum are the regions with the smallest standard deviations of the mean susceptibility value. The mean susceptibility is 0.010 ± 0.014 ppm for CSF in the atrium of the lateral ventricles (csf post ), -0.060 ± 0.019 ppm for the posterior limb of the internal capsule (ci2), and -0.008 ± 0.019 ppm for the splenium of the corpus callosum. csf post and ci2 show nearly no dependence on age or stage of disease, whereas some other regions, e.g., the red nucleus, show moderate dependence on age or disease. The internal capsule and CSF appear to be the most suitable reference regions for QSM of the brain in the melanoma patients studied. Both showed virtually no dependence on age or disease and small variations among patients. Magn Reson Med 78:204-214, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  8. Parametric methods for characterizing myocardial tissue by magnetic resonance imaging (part 2): T2 mapping.

    Science.gov (United States)

    Perea Palazón, R J; Solé Arqués, M; Prat González, S; de Caralt Robira, T M; Cibeira López, M T; Ortiz Pérez, J T

    2015-01-01

    Cardiac magnetic resonance imaging is considered the reference technique for characterizing myocardial tissue; for example, T2-weighted sequences make it possible to evaluate areas of edema or myocardial inflammation. However, traditional sequences have many limitations and provide only qualitative information. Moreover, traditional sequences depend on the reference to remote myocardium or skeletal muscle, which limits their ability to detect and quantify diffuse myocardial damage. Recently developed magnetic resonance myocardial mapping techniques enable quantitative assessment of parameters indicative of edema. These techniques have proven better than traditional sequences both in acute cardiomyopathy and in acute ischemic heart disease. This article synthesizes current developments in T2 mapping as well as their clinical applications and limitations. Copyright © 2014 SERAM. Published by Elsevier España, S.L.U. All rights reserved.

  9. Tissue microarrays and their use for preparation of reference slides ...

    African Journals Online (AJOL)

    Use of Tissue array was first applied in 1998, and has received a significant amount of attention from the research community ever since. In this technique, a large number (up to 1000) of cylindrical tissue core extracted from \\"donor\\" paraffin block are deposited into \\"recipient\\" block. The aim was modification of the ...

  10. Parametrized post-Newtonian theory of reference frames, multipolar expansions and equations of motion in the N-body problem

    International Nuclear Information System (INIS)

    Kopeikin, Sergei; Vlasov, Igor

    2004-01-01

    Post-Newtonian relativistic theory of astronomical reference frames based on Einstein's general theory of relativity was adopted by General Assembly of the International Astronomical Union in 2000. This theory is extended in the present paper by taking into account all relativistic effects caused by the presumable existence of a scalar field and parametrized by two parameters, β and γ, of the parametrized post-Newtonian (PPN) formalism. We use a general class of the scalar-tensor (Brans-Dicke type) theories of gravitation to work out PPN concepts of global and local reference frames for an astronomical N-body system. The global reference frame is a standard PPN coordinate system. A local reference frame is constructed in the vicinity of a weakly self-gravitating body (a sub-system of the bodies) that is a member of the astronomical N-body system. Such local inertial frame is required for unambiguous derivation of the equations of motion of the body in the field of other members of the N-body system and for construction of adequate algorithms for data analysis of various gravitational experiments conducted in ground-based laboratories and/or on board of spacecrafts in the solar system.We assume that the bodies comprising the N-body system have weak gravitational field and move slowly. At the same time we do not impose any specific limitations on the distribution of density, velocity and the equation of state of the body's matter. Scalar-tensor equations of the gravitational field are solved by making use of the post-Newtonian approximations so that the metric tensor and the scalar field are obtained as functions of the global and local coordinates. A correspondence between the local and global coordinate frames is found by making use of asymptotic expansion matching technique. This technique allows us to find a class of the post-Newtonian coordinate transformations between the frames as well as equations of translational motion of the origin of the local frame

  11. Reference Models for Multi-Layer Tissue Structures

    Science.gov (United States)

    2016-09-01

    function of multi-layer tissues (etiology and management of pressure ulcers ). What was the impact on other disciplines? As part of the project, a data...simplification to develop cost -effective models of surface manipulation of multi-layer tissues. Deliverables. Specimen- (or subject) and region-specific...simplification to develop cost -effective models of surgical manipulation. Deliverables. Specimen-specific surrogate models of upper legs confirmed against data

  12. Suitability of stratagene reference RNA for analysis of lymphoid tissues

    DEFF Research Database (Denmark)

    Dybkaer, Karen; Zhou, Guimei; Iqbal, Javeed

    2004-01-01

    acceptable gene coverage to serve as a comprehensive standard for gene expression profiling of lymphoid tissues. Our lymphoid standard was prepared from thymus, spleen, tonsil, and cell lines representing immature B cells, plasma cells, and natural killer (NK) cells, thus covering the entire spectrum...... of lymphoid cells and most stromal elements present in specialized lymphoid tissues. The two standards were co-hybridized on oligonucleotide microarrays containing 17,260 genes, and both had fluorescence intensities above background for approximately 85% of the genes. Despite the limited representation...... of lymphoid cells in the Stratagene standard, only 4.2% genes exhibited expression differences greater than 2-fold including only 0.35% with differences greater than 4-fold. Although the lymphoid standard reflected a more comprehensive representation of immune system-associated genes, the Stratagene standard...

  13. Brain tissues volume measurements from 2D MRI using parametric approach

    Science.gov (United States)

    L'vov, A. A.; Toropova, O. A.; Litovka, Yu. V.

    2018-04-01

    The purpose of the paper is to propose a fully automated method of volume assessment of structures within human brain. Our statistical approach uses maximum interdependency principle for decision making process of measurements consistency and unequal observations. Detecting outliers performed using maximum normalized residual test. We propose a statistical model which utilizes knowledge of tissues distribution in human brain and applies partial data restoration for precision improvement. The approach proposes completed computationally efficient and independent from segmentation algorithm used in the application.

  14. A method to obtain reference images for evaluation of ultrasonic tissue characterization techniques

    DEFF Research Database (Denmark)

    Jensen, M.S.; Wilhjelm, Jens E.; Sahl, B.

    2002-01-01

    of the macroscopic photograph, due to the histological preparation process. The histological information was "mapped back" into the format of the ultrasound images the following way: On the macroscopic images, outlines were drawn manually which defined the border of the tissue. These outlines were superimposed...... of the various tissue types. Specifically, the macroscopic image revealed the borders between the different tissues, while the histological image identified the four tissue types. A set of 12 reference images based on modified macroscopic outlines was created. The overlap between the ultrasound images...... and the macroscopic images-which are the geometrical basis for the final reference images-was between 77% and 93%. A set of 12 reference images spaced 2.5 mm, identifying spatial location of four different tissue types in porcine muscle has been created. With the reference images, it is possible to quantitatively...

  15. Parametric techniques for characterizing myocardial tissue by magnetic resonance imaging (part 1): T1 mapping.

    Science.gov (United States)

    Perea Palazón, R J; Ortiz Pérez, J T; Prat González, S; de Caralt Robira, T M; Cibeira López, M T; Solé Arqués, M

    2016-01-01

    The development of myocardial fibrosis is a common process in the appearance of ventricular dysfunction in many heart diseases. Magnetic resonance imaging makes it possible to accurately evaluate the structure and function of the heart, and its role in the macroscopic characterization of myocardial fibrosis by late enhancement techniques has been widely validated clinically. Recent studies have demonstrated that T1-mapping techniques can quantify diffuse myocardial fibrosis and the expansion of the myocardial extracellular space in absolute terms. However, further studies are necessary to validate the usefulness of this technique in the early detection of tissue remodeling at a time when implementing early treatment would improve a patient's prognosis. This article reviews the state of the art for T1 mapping of the myocardium, its clinical applications, and its limitations. Copyright © 2016 SERAM. Published by Elsevier España, S.L.U. All rights reserved.

  16. Modelling of Cortical Bone Tissue as a Fluid Saturated Double-Porous Material - Parametric Study

    Directory of Open Access Journals (Sweden)

    Jana TURJANICOVÁ

    2013-06-01

    Full Text Available In this paper, the cortical bone tissue is considered as a poroelastic material with periodic structure represented at microscopic and mesoscopic levels. The pores of microscopic scale are connected with the pores of mesoscopic scale creating one system of connected network filled with compressible fluid. The method of asymptotic homogenization is applied to upscale the microscopic model of the fluid-solid interaction under a static loading. Obtained homogenized coefficients describe material properties of the poroelastic matrix fractured by fluid-filled pores whose geometry is described at the mesoscopic level. The second-level upscaling provides homogenized poroelastic coefficients relevant on the macroscopic scale. Furthermore, we study the dependence of these coefficients on geometrical parameters on related microscopic and macroscopic scales.

  17. Comparison of plasma input and reference tissue models for analysing [(11)C]flumazenil studies

    NARCIS (Netherlands)

    Klumpers, Ursula M. H.; Veltman, Dick J.; Boellaard, Ronald; Comans, Emile F.; Zuketto, Cassandra; Yaqub, Maqsood; Mourik, Jurgen E. M.; Lubberink, Mark; Hoogendijk, Witte J. G.; Lammertsma, Adriaan A.

    2008-01-01

    A single-tissue compartment model with plasma input is the established method for analysing [(11)C]flumazenil ([(11)C]FMZ) studies. However, arterial cannulation and measurement of metabolites are time-consuming. Therefore, a reference tissue approach is appealing, but this approach has not been

  18. Identification of reference genes and validation for gene expression studies in diverse axolotl (Ambystoma mexicanum) tissues.

    Science.gov (United States)

    Guelke, Eileen; Bucan, Vesna; Liebsch, Christina; Lazaridis, Andrea; Radtke, Christine; Vogt, Peter M; Reimers, Kerstin

    2015-04-10

    For the precise quantitative RT-PCR normalization a set of valid reference genes is obligatory. Moreover have to be taken into concern the experimental conditions as they bias the regulation of reference genes. Up till now, no reference targets have been described for the axolotl (Ambystoma mexicanum). In a search in the public database SalSite for genetic information of the axolotl we identified fourteen presumptive reference genes, eleven of which were further tested for their gene expression stability. This study characterizes the expressional patterns of 11 putative endogenous control genes during axolotl limb regeneration and in an axolotl tissue panel. All 11 reference genes showed variable expression. Strikingly, ACTB was to be found most stable expressed in all comparative tissue groups, so we reason it to be suitable for all different kinds of axolotl tissue-type investigations. Moreover do we suggest GAPDH and RPLP0 as suitable for certain axolotl tissue analysis. When it comes to axolotl limb regeneration, a validated pair of reference genes is ODC and RPLP0. With these findings, new insights into axolotl gene expression profiling might be gained. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Validation of reference genes in Solenopsis invicta in different developmental stages, castes and tissues.

    Directory of Open Access Journals (Sweden)

    Daifeng Cheng

    Full Text Available To accurately assess gene expression levels, it is essential to normalize real-time quantitative PCR (RT-qPCR data with suitable internal reference genes. For the red imported fire ant, Solenopsis invicta, reliable reference genes to assess the transcript expression levels of the target genes have not been previously investigated. In this study, we examined the expression levels of five candidate reference genes (rpl18, ef1-beta, act, GAPDH, and tbp in different developmental stages, castes and tissues of S. invicta. To evaluate the suitability of these genes as endogenous controls, three software-based approaches (geNorm, BestKeeper and NormFinder and one web-based comprehensive tool (RefFinder were used to analyze and rank the tested genes. Furthermore, the optimal number of reference gene(s was determined by the pairwise variation value. Our data showed that two of the five candidate genes, rpl18 and ef1-beta, were the most suitable reference genes because they have the most stable expression among different developmental stages, castes and tissues in S. invicta. Although widely used as reference gene in other species, in S. invicta the act gene has high variation in expression and was consequently excluded as a reliable reference gene. The two validated reference genes, rpl18 and ef1-beta, can be widely used for quantification of target gene expression with RT-qPCR technology in S. invicta.

  20. A protein-based set of reference markers for liver tissues and hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Sun, Stella; Yi, Xin; Poon, Ronnie TP; Yeung, Chun; Day, Philip JR; Luk, John M

    2009-01-01

    During the last decade, investigations have focused on revealing genes or proteins that are involved in HCC carcinogenesis using either genetic or proteomic techniques. However, these studies are overshadowed by a lack of good internal reference standards. The need to identify 'housekeeping' markers, whose expression is stable in various experimental and clinical conditions, is therefore of the utmost clinical relevance in quantitative studies. This is the first study employed 2-DE analysis to screen for potential reference markers and aims to correlate the abundance of these proteins with their level of transcript expression. A Chinese cohort of 224 liver tissues samples (105 cancerous, 103 non-tumourous cirrhotic, and 16 normal) was profiled using 2-DE analysis. Expression of the potential reference markers was confirmed by western blot, immunohistochemistry and real-time quantitative PCR. geNorm algorithm was employed for gene stability measure of the identified reference markers. The expression levels of three protein markers beta-actin (ACTB), heat shock protein 60 (HSP60), and protein disulphide isomerase (PDI) were found to be stable using p-values (p > 0.99) as a ranking tool in all 224 human liver tissues examined by 2-DE analysis. Of high importance, ACTB and HSP 60 were successfully validated at both protein and mRNA levels in human hepatic tissues by western blot, immunohistochemistry and real-time quantitative PCR. In addition, no significant correlation of these markers with any clinicopathological features of HCC and cirrhosis was found. Gene stability measure of these two markers with other conventionally applied housekeeping genes was assessed by the geNorm algorithm, which ranked ACTB and HSP60 as the most stable genes among this cohort of clinical samples. Our findings identified 2 reference markers that exhibited stable expression across human liver tissues with different conditions thus should be regarded as reliable reference

  1. Investigation of Turbulence Parametrization Schemes with Reference to the Atmospheric Boundary Layer Over the Aegean Sea During Etesian Winds

    Science.gov (United States)

    Dandou, A.; Tombrou, M.; Kalogiros, J.; Bossioli, E.; Biskos, G.; Mihalopoulos, N.; Coe, H.

    2017-08-01

    The spatial structure of the marine atmospheric boundary layer (MABL) over the Aegean Sea is investigated using the Weather Research and Forecasting (WRF) mesoscale model. Two `first-order' non-local and five `1.5-order' local planetary boundary-layer (PBL) parametrization schemes are used. The predictions from the WRF model are evaluated against airborne observations obtained by the UK Facility for Airborne Atmospheric Measurements BAe-14 research aircraft during the Aegean-GAME field campaign. Statistical analysis shows good agreement between measurements and simulations especially at low altitude. Despite the differences between the predicted and measured wind speeds, they reach an agreement index of 0.76. The simulated wind-speed fields close to the surface differ substantially among the schemes (maximum values range from 13 to 18 m s^{-1} at 150-m height), but the differences become marginal at higher levels. In contrast, all schemes show similar spatial variation patterns in potential temperature fields. A warmer (1-2 K) and drier (2-3 g kg^{-1}) layer than is observed, is predicted by almost all schemes under stable conditions (eastern Aegean Sea), whereas a cooler (up to 2 K) and moister (1-2 g kg^{-1}) layer is simulated under near-neutral to nearly unstable conditions (western Aegean Sea). Almost all schemes reproduce the vertical structure of the PBL and the shallow MABL (up to 300 m) well, including the low-level jet in the eastern Aegean Sea, with non-local schemes being closer to observations. The simulated PBL depths diverge (up to 500 m) due to the different criteria applied by the schemes for their calculation. Under stable conditions, the observed MABL depth corresponds to the height above the sea surface where the simulated eddy viscosity reaches a minimum; under neutral to slightly unstable conditions this is close to the top of the simulated entrainment layer. The observed sensible heat fluxes vary from -40 to 25 W m^{-2}, while the simulated

  2. Automated segmentation of reference tissue for prostate cancer localization in dynamic contrast enhanced MRI

    Science.gov (United States)

    Vos, Pieter C.; Hambrock, Thomas; Barentsz, Jelle O.; Huisman, Henkjan J.

    2010-03-01

    For pharmacokinetic (PK) analysis of Dynamic Contrast Enhanced (DCE) MRI the arterial input function needs to be estimated. Previously, we demonstrated that PK parameters have a significant better discriminative performance when per patient reference tissue was used, but required manual annotation of reference tissue. In this study we propose a fully automated reference tissue segmentation method that tackles this limitation. The method was tested with our Computer Aided Diagnosis (CADx) system to study the effect on the discriminating performance for differentiating prostate cancer from benign areas in the peripheral zone (PZ). The proposed method automatically segments normal PZ tissue from DCE derived data. First, the bladder is segmented in the start-to-enhance map using the Otsu histogram threshold selection method. Second, the prostate is detected by applying a multi-scale Hessian filter to the relative enhancement map. Third, normal PZ tissue was segmented by threshold and morphological operators. The resulting segmentation was used as reference tissue to estimate the PK parameters. In 39 consecutive patients carcinoma, benign and normal tissue were annotated on MR images by a radiologist and a researcher using whole mount step-section histopathology as reference. PK parameters were computed for each ROI. Features were extracted from the set of ROIs using percentiles to train a support vector machine that was used as classifier. Prospective performance was estimated by means of leave-one-patient-out cross validation. A bootstrap resampling approach with 10,000 iterations was used for estimating the bootstrap mean AUCs and 95% confidence intervals. In total 42 malignant, 29 benign and 37 normal regions were annotated. For all patients, normal PZ was successfully segmented. The diagnostic accuracy obtained for differentiating malignant from benign lesions using a conventional general patient plasma profile showed an accuracy of 0.64 (0.53-0.74). Using the

  3. Serum prolactin revisited: parametric reference intervals and cross platform evaluation of polyethylene glycol precipitation-based methods for discrimination between hyperprolactinemia and macroprolactinemia.

    Science.gov (United States)

    Overgaard, Martin; Pedersen, Susanne Møller

    2017-10-26

    Hyperprolactinemia diagnosis and treatment is often compromised by the presence of biologically inactive and clinically irrelevant higher-molecular-weight complexes of prolactin, macroprolactin. The objective of this study was to evaluate the performance of two macroprolactin screening regimes across commonly used automated immunoassay platforms. Parametric total and monomeric gender-specific reference intervals were determined for six immunoassay methods using female (n=96) and male sera (n=127) from healthy donors. The reference intervals were validated using 27 hyperprolactinemic and macroprolactinemic sera, whose presence of monomeric and macroforms of prolactin were determined using gel filtration chromatography (GFC). Normative data for six prolactin assays included the range of values (2.5th-97.5th percentiles). Validation sera (hyperprolactinemic and macroprolactinemic; n=27) showed higher discordant classification [mean=2.8; 95% confidence interval (CI) 1.2-4.4] for the monomer reference interval method compared to the post-polyethylene glycol (PEG) recovery cutoff method (mean=1.8; 95% CI 0.8-2.8). The two monomer/macroprolactin discrimination methods did not differ significantly (p=0.089). Among macroprolactinemic sera evaluated by both discrimination methods, the Cobas and Architect/Kryptor prolactin assays showed the lowest and the highest number of misclassifications, respectively. Current automated immunoassays for prolactin testing require macroprolactin screening methods based on PEG precipitation in order to discriminate truly from falsely elevated serum prolactin. While the recovery cutoff and monomeric reference interval macroprolactin screening methods demonstrate similar discriminative ability, the latter method also provides the clinician with an easy interpretable monomeric prolactin concentration along with a monomeric reference interval.

  4. Evaluation of suitable reference genes for gene expression studies in bovine muscular tissue

    Directory of Open Access Journals (Sweden)

    Dunner Susana

    2008-09-01

    Full Text Available Abstract Background Real-time reverse transcriptase quantitative polymerase chain reaction (real-time RTqPCR is a technique used to measure mRNA species copy number as a way to determine key genes involved in different biological processes. However, the expression level of these key genes may vary among tissues or cells not only as a consequence of differential expression but also due to different factors, including choice of reference genes to normalize the expression levels of the target genes; thus the selection of reference genes is critical for expression studies. For this purpose, ten candidate reference genes were investigated in bovine muscular tissue. Results The value of stability of ten candidate reference genes included in three groups was estimated: the so called 'classical housekeeping' genes (18S, GAPDH and ACTB, a second set of genes used in expression studies conducted on other tissues (B2M, RPII, UBC and HMBS and a third set of novel genes (SF3A1, EEF1A2 and CASC3. Three different statistical algorithms were used to rank the genes by their stability measures as produced by geNorm, NormFinder and Bestkeeper. The three methods tend to agree on the most stably expressed genes and the least in muscular tissue. EEF1A2 and HMBS followed by SF3A1, ACTB, and CASC3 can be considered as stable reference genes, and B2M, RPII, UBC and GAPDH would not be appropriate. Although the rRNA-18S stability measure seems to be within the range of acceptance, its use is not recommended because its synthesis regulation is not representative of mRNA levels. Conclusion Based on geNorm algorithm, we propose the use of three genes SF3A1, EEF1A2 and HMBS as references for normalization of real-time RTqPCR in muscle expression studies.

  5. Identification of Reference Genes for RT-qPCR Data Normalization in Cannabis sativa Stem Tissues

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    Lauralie Mangeot-Peter

    2016-09-01

    Full Text Available Gene expression profiling via quantitative real-time PCR is a robust technique widely used in the life sciences to compare gene expression patterns in, e.g., different tissues, growth conditions, or after specific treatments. In the field of plant science, real-time PCR is the gold standard to study the dynamics of gene expression and is used to validate the results generated with high throughput techniques, e.g., RNA-Seq. An accurate relative quantification of gene expression relies on the identification of appropriate reference genes, that need to be determined for each experimental set-up used and plant tissue studied. Here, we identify suitable reference genes for expression profiling in stems of textile hemp (Cannabis sativa L., whose tissues (isolated bast fibres and core are characterized by remarkable differences in cell wall composition. We additionally validate the reference genes by analysing the expression of putative candidates involved in the non-oxidative phase of the pentose phosphate pathway and in the first step of the shikimate pathway. The goal is to describe the possible regulation pattern of some genes involved in the provision of the precursors needed for lignin biosynthesis in the different hemp stem tissues. The results here shown are useful to design future studies focused on gene expression analyses in hemp.

  6. Identification of Reference Genes for RT-qPCR Data Normalization in Cannabis sativa Stem Tissues.

    Science.gov (United States)

    Mangeot-Peter, Lauralie; Legay, Sylvain; Hausman, Jean-Francois; Esposito, Sergio; Guerriero, Gea

    2016-09-15

    Gene expression profiling via quantitative real-time PCR is a robust technique widely used in the life sciences to compare gene expression patterns in, e.g., different tissues, growth conditions, or after specific treatments. In the field of plant science, real-time PCR is the gold standard to study the dynamics of gene expression and is used to validate the results generated with high throughput techniques, e.g., RNA-Seq. An accurate relative quantification of gene expression relies on the identification of appropriate reference genes, that need to be determined for each experimental set-up used and plant tissue studied. Here, we identify suitable reference genes for expression profiling in stems of textile hemp (Cannabis sativa L.), whose tissues (isolated bast fibres and core) are characterized by remarkable differences in cell wall composition. We additionally validate the reference genes by analysing the expression of putative candidates involved in the non-oxidative phase of the pentose phosphate pathway and in the first step of the shikimate pathway. The goal is to describe the possible regulation pattern of some genes involved in the provision of the precursors needed for lignin biosynthesis in the different hemp stem tissues. The results here shown are useful to design future studies focused on gene expression analyses in hemp.

  7. Validation of putative reference genes for normalization of Q-RT-PCR data from paraffin-embedded lymphoid tissue

    DEFF Research Database (Denmark)

    Green, Tina Marie; de Stricker, Karin; Møller, Michael Boe

    2009-01-01

    Normalization of quantitative reverse transcription-PCR (Q-RT-PCR) data to appropriate tissue-specific reference genes is an essential part of interpreting the results. This study aimed to determine the most appropriate reference genes for normalizing gene expressions in lymphatic tissue...... was 0.93 (Pnormalization with the appropriate reference genes. Thus, we show that formalin-fixed, paraffin-embedded lymphoid samples are suitable for Q-RT-PCR when using thoroughly validated reference genes....

  8. Multivariate reference technique for quantitative analysis of fiber-optic tissue Raman spectroscopy.

    Science.gov (United States)

    Bergholt, Mads Sylvest; Duraipandian, Shiyamala; Zheng, Wei; Huang, Zhiwei

    2013-12-03

    We report a novel method making use of multivariate reference signals of fused silica and sapphire Raman signals generated from a ball-lens fiber-optic Raman probe for quantitative analysis of in vivo tissue Raman measurements in real time. Partial least-squares (PLS) regression modeling is applied to extract the characteristic internal reference Raman signals (e.g., shoulder of the prominent fused silica boson peak (~130 cm(-1)); distinct sapphire ball-lens peaks (380, 417, 646, and 751 cm(-1))) from the ball-lens fiber-optic Raman probe for quantitative analysis of fiber-optic Raman spectroscopy. To evaluate the analytical value of this novel multivariate reference technique, a rapid Raman spectroscopy system coupled with a ball-lens fiber-optic Raman probe is used for in vivo oral tissue Raman measurements (n = 25 subjects) under 785 nm laser excitation powers ranging from 5 to 65 mW. An accurate linear relationship (R(2) = 0.981) with a root-mean-square error of cross validation (RMSECV) of 2.5 mW can be obtained for predicting the laser excitation power changes based on a leave-one-subject-out cross-validation, which is superior to the normal univariate reference method (RMSE = 6.2 mW). A root-mean-square error of prediction (RMSEP) of 2.4 mW (R(2) = 0.985) can also be achieved for laser power prediction in real time when we applied the multivariate method independently on the five new subjects (n = 166 spectra). We further apply the multivariate reference technique for quantitative analysis of gelatin tissue phantoms that gives rise to an RMSEP of ~2.0% (R(2) = 0.998) independent of laser excitation power variations. This work demonstrates that multivariate reference technique can be advantageously used to monitor and correct the variations of laser excitation power and fiber coupling efficiency in situ for standardizing the tissue Raman intensity to realize quantitative analysis of tissue Raman measurements in vivo, which is particularly appealing in

  9. An image-based skeletal tissue model for the ICRP reference newborn

    Energy Technology Data Exchange (ETDEWEB)

    Pafundi, Deanna; Lee, Choonsik; Bolch, Wesley [Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, FL (United States); Watchman, Christopher; Bourke, Vincent [Department of Radiation Oncology, University of Arizona, Tucson, AZ (United States); Aris, John [Department of Anatomy and Cell Biology, University of Florida, Gainesville, FL (United States); Shagina, Natalia [Urals Research Center for Radiation Medicine, Chelyabinsk (Russian Federation); Harrison, John; Fell, Tim [Radiation Protection Division, Health Protection Agency, Chilton (United Kingdom)], E-mail: wbolch@ufl.edu

    2009-07-21

    Hybrid phantoms represent a third generation of computational models of human anatomy needed for dose assessment in both external and internal radiation exposures. Recently, we presented the first whole-body hybrid phantom of the ICRP reference newborn with a skeleton constructed from both non-uniform rational B-spline and polygon-mesh surfaces (Lee et al 2007 Phys. Med. Biol. 52 3309-33). The skeleton in that model included regions of cartilage and fibrous connective tissue, with the remainder given as a homogenous mixture of cortical and trabecular bone, active marrow and miscellaneous skeletal tissues. In the present study, we present a comprehensive skeletal tissue model of the ICRP reference newborn to permit a heterogeneous representation of the skeleton in that hybrid phantom set-both male and female-that explicitly includes a delineation of cortical bone so that marrow shielding effects are correctly modeled for low-energy photons incident upon the newborn skeleton. Data sources for the tissue model were threefold. First, skeletal site-dependent volumes of homogeneous bone were obtained from whole-cadaver CT image analyses. Second, selected newborn bone specimens were acquired at autopsy and subjected to micro-CT image analysis to derive model parameters of the marrow cavity and bone trabecular 3D microarchitecture. Third, data given in ICRP Publications 70 and 89 were selected to match reference values on total skeletal tissue mass. Active marrow distributions were found to be in reasonable agreement with those given previously by the ICRP. However, significant differences were seen in total skeletal and site-specific masses of trabecular and cortical bone between the current and ICRP newborn skeletal tissue models. The latter utilizes an age-independent ratio of 80%/20% cortical and trabecular bone for the reference newborn. In the current study, a ratio closer to 40%/60% is used based upon newborn CT and micro-CT skeletal image analyses. These changes in

  10. Reference tissue modeling with parameter coupling: application to a study of SERT binding in HIV

    Energy Technology Data Exchange (ETDEWEB)

    Endres, Christopher J; Pomper, Martin G [Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21231 (United States); Hammoud, Dima A, E-mail: endres@jhmi.edu [Radiology and Imaging Sciences, National Institutes of Health/Clinical Center, Bethesda, MD (United States)

    2011-04-21

    When applicable, it is generally preferred to evaluate positron emission tomography (PET) studies using a reference tissue-based approach as that avoids the need for invasive arterial blood sampling. However, most reference tissue methods have been shown to have a bias that is dependent on the level of tracer binding, and the variability of parameter estimates may be substantially affected by noise level. In a study of serotonin transporter (SERT) binding in HIV dementia, it was determined that applying parameter coupling to the simplified reference tissue model (SRTM) reduced the variability of parameter estimates and yielded the strongest between-group significant differences in SERT binding. The use of parameter coupling makes the application of SRTM more consistent with conventional blood input models and reduces the total number of fitted parameters, thus should yield more robust parameter estimates. Here, we provide a detailed evaluation of the application of parameter constraint and parameter coupling to [{sup 11}C]DASB PET studies. Five quantitative methods, including three methods that constrain the reference tissue clearance (k{sup r}{sub 2}) to a common value across regions were applied to the clinical and simulated data to compare measurement of the tracer binding potential (BP{sub ND}). Compared with standard SRTM, either coupling of k{sup r}{sub 2} across regions or constraining k{sup r}{sub 2} to a first-pass estimate improved the sensitivity of SRTM to measuring a significant difference in BP{sub ND} between patients and controls. Parameter coupling was particularly effective in reducing the variance of parameter estimates, which was less than 50% of the variance obtained with standard SRTM. A linear approach was also improved when constraining k{sup r}{sub 2} to a first-pass estimate, although the SRTM-based methods yielded stronger significant differences when applied to the clinical study. This work shows that parameter coupling reduces the

  11. Distributed capillary adiabatic tissue homogeneity model in parametric multi-channel blind AIF estimation using DCE-MRI.

    Science.gov (United States)

    Kratochvíla, Jiří; Jiřík, Radovan; Bartoš, Michal; Standara, Michal; Starčuk, Zenon; Taxt, Torfinn

    2016-03-01

    One of the main challenges in quantitative dynamic contrast-enhanced (DCE) MRI is estimation of the arterial input function (AIF). Usually, the signal from a single artery (ignoring contrast dispersion, partial volume effects and flow artifacts) or a population average of such signals (also ignoring variability between patients) is used. Multi-channel blind deconvolution is an alternative approach avoiding most of these problems. The AIF is estimated directly from the measured tracer concentration curves in several tissues. This contribution extends the published methods of multi-channel blind deconvolution by applying a more realistic model of the impulse residue function, the distributed capillary adiabatic tissue homogeneity model (DCATH). In addition, an alternative AIF model is used and several AIF-scaling methods are tested. The proposed method is evaluated on synthetic data with respect to the number of tissue regions and to the signal-to-noise ratio. Evaluation on clinical data (renal cell carcinoma patients before and after the beginning of the treatment) gave consistent results. An initial evaluation on clinical data indicates more reliable and less noise sensitive perfusion parameter estimates. Blind multi-channel deconvolution using the DCATH model might be a method of choice for AIF estimation in a clinical setup. © 2015 Wiley Periodicals, Inc.

  12. Detailing the relation between renal T2* and renal tissue pO2 using an integrated approach of parametric magnetic resonance imaging and invasive physiological measurements.

    Science.gov (United States)

    Pohlmann, Andreas; Arakelyan, Karen; Hentschel, Jan; Cantow, Kathleen; Flemming, Bert; Ladwig, Mechthild; Waiczies, Sonia; Seeliger, Erdmann; Niendorf, Thoralf

    2014-08-01

    This study was designed to detail the relation between renal T2* and renal tissue pO2 using an integrated approach that combines parametric magnetic resonance imaging (MRI) and quantitative physiological measurements (MR-PHYSIOL). Experiments were performed in 21 male Wistar rats. In vivo modulation of renal hemodynamics and oxygenation was achieved by brief periods of aortic occlusion, hypoxia, and hyperoxia. Renal perfusion pressure (RPP), renal blood flow (RBF), local cortical and medullary tissue pO2, and blood flux were simultaneously recorded together with T2*, T2 mapping, and magnetic resonance-based kidney size measurements (MR-PHYSIOL). Magnetic resonance imaging was carried out on a 9.4-T small-animal magnetic resonance system. Relative changes in the invasive quantitative parameters were correlated with relative changes in the parameters derived from MRI using Spearman analysis and Pearson analysis. Changes in T2* qualitatively reflected tissue pO2 changes induced by the interventions. T2* versus pO2 Spearman rank correlations were significant for all interventions, yet quantitative translation of T2*/pO2 correlations obtained for one intervention to another intervention proved not appropriate. The closest T2*/pO2 correlation was found for hypoxia and recovery. The interlayer comparison revealed closest T2*/pO2 correlations for the outer medulla and showed that extrapolation of results obtained for one renal layer to other renal layers must be made with due caution. For T2* to RBF relation, significant Spearman correlations were deduced for all renal layers and for all interventions. T2*/RBF correlations for the cortex and outer medulla were even superior to those between T2* and tissue pO2. The closest T2*/RBF correlation occurred during hypoxia and recovery. Close correlations were observed between T2* and kidney size during hypoxia and recovery and for occlusion and recovery. In both cases, kidney size correlated well with renal vascular conductance

  13. Development of reference material for proficiency tests: arsenic in fish tissue

    International Nuclear Information System (INIS)

    Santana, Luciana Vieira de; Sarkis, Jorge E.S.; Ulrich, Joao C.; Hortellani, Marcos Antonio

    2013-01-01

    Proficiency tests (PT) are extensively used to evaluate the analytical competence of laboratories, and are also used as a part of accreditation processes. For this reason are important tool for quality control of laboratories including laboratories that act directly with food exporting companies. In Brazil there are no providers of proficiency testing for toxic metals, such as arsenic in fish tissue. This study presents a protocol to produce reference material to be used in proficiency test for arsenic in fish tissue following the recommendations of the ISO Guide 35. The preparation scheme consisted of: selecting of individuals, cleaning of scale and skin, trituration, homogenization, and spiking with arsenic at two levels of concentration. The mixture was then irradiated in a cyclotron Cyclone 30 Applications ion beam with cobalt 60 at 10.00 ± 1.05 KGy, before being packed into sachets. To verify the efficacy of the irradiation procedure, 26 (randomly selected) irradiated sachets and 26 non-irradiated sachets were assessed for homogeneity and stability. The results indicate that irradiation with cobalt 60 is crucial for ensuring the preservation of the integrity of the material, providing stable material at room temperature for 2 months. The samples can therefore be transported at room temperature. (author)

  14. Development of reference material for proficiency tests: arsenic in fish tissue

    Energy Technology Data Exchange (ETDEWEB)

    Santana, Luciana Vieira de; Sarkis, Jorge E.S.; Ulrich, Joao C.; Hortellani, Marcos Antonio, E-mail: santana-luciana@ig.com.br, E-mail: jesarkis@ipen.br, E-mail: jculrich@ipen.br, E-mail: mahortel@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Proficiency tests (PT) are extensively used to evaluate the analytical competence of laboratories, and are also used as a part of accreditation processes. For this reason are important tool for quality control of laboratories including laboratories that act directly with food exporting companies. In Brazil there are no providers of proficiency testing for toxic metals, such as arsenic in fish tissue. This study presents a protocol to produce reference material to be used in proficiency test for arsenic in fish tissue following the recommendations of the ISO Guide 35. The preparation scheme consisted of: selecting of individuals, cleaning of scale and skin, trituration, homogenization, and spiking with arsenic at two levels of concentration. The mixture was then irradiated in a cyclotron Cyclone 30 Applications ion beam with cobalt 60 at 10.00 ± 1.05 KGy, before being packed into sachets. To verify the efficacy of the irradiation procedure, 26 (randomly selected) irradiated sachets and 26 non-irradiated sachets were assessed for homogeneity and stability. The results indicate that irradiation with cobalt 60 is crucial for ensuring the preservation of the integrity of the material, providing stable material at room temperature for 2 months. The samples can therefore be transported at room temperature. (author)

  15. A simple method for measuring glucose utilization of insulin-sensitive tissues by using the brain as a reference

    International Nuclear Information System (INIS)

    Namba, Hiroki; Nakagawa, Keiichi; Iyo, Masaomi; Fukushi, Kiyoshi; Irie, Toshiaki

    1994-01-01

    A simple method, without measurement of the plasma input function, to obtain semiquantitative values of glucose utilization in tissues other than the brain with radioactive deoxyglucose is reported. The brain, in which glucose utilization is essentially insensitive to plasma glucose and insulin concentrations, was used as an internal reference. The effects of graded doses of oral glucose loading (0.5, 1 and 2 mg/g body weight) on insulin-sensitive tissues (heart, muscle and fat tissue) were studied in the rat. By using the brain-reference method, dose-dependent increases in glucose utilization were clearly shown in all the insulin-sensitive tissues examined. The method seems to be of value for measurement of glucose utilization using radioactive deoxyglucose and positron emission tomography in the heart or other insulin-sensitive tissues, especially during glucose loading. (orig.)

  16. A survey of clearing techniques for 3D imaging of tissues with special reference to connective tissue.

    Science.gov (United States)

    Azaripour, Adriano; Lagerweij, Tonny; Scharfbillig, Christina; Jadczak, Anna Elisabeth; Willershausen, Brita; Van Noorden, Cornelis J F

    2016-08-01

    For 3-dimensional (3D) imaging of a tissue, 3 methodological steps are essential and their successful application depends on specific characteristics of the type of tissue. The steps are 1° clearing of the opaque tissue to render it transparent for microscopy, 2° fluorescence labeling of the tissues and 3° 3D imaging. In the past decades, new methodologies were introduced for the clearing steps with their specific advantages and disadvantages. Most clearing techniques have been applied to the central nervous system and other organs that contain relatively low amounts of connective tissue including extracellular matrix. However, tissues that contain large amounts of extracellular matrix such as dermis in skin or gingiva are difficult to clear. The present survey lists methodologies that are available for clearing of tissues for 3D imaging. We report here that the BABB method using a mixture of benzyl alcohol and benzyl benzoate and iDISCO using dibenzylether (DBE) are the most successful methods for clearing connective tissue-rich gingiva and dermis of skin for 3D histochemistry and imaging of fluorescence using light-sheet microscopy. Copyright © 2016 The Authors. Published by Elsevier GmbH.. All rights reserved.

  17. Selection of reference genes for tissue/organ samples on day 3 fifth-instar larvae in silkworm, Bombyx mori.

    Science.gov (United States)

    Wang, Genhong; Chen, Yanfei; Zhang, Xiaoying; Bai, Bingchuan; Yan, Hao; Qin, Daoyuan; Xia, Qingyou

    2018-06-01

    The silkworm, Bombyx mori, is one of the world's most economically important insect. Surveying variations in gene expression among multiple tissue/organ samples will provide clues for gene function assignments and will be helpful for identifying genes related to economic traits or specific cellular processes. To ensure their accuracy, commonly used gene expression quantification methods require a set of stable reference genes for data normalization. In this study, 24 candidate reference genes were assessed in 10 tissue/organ samples of day 3 fifth-instar B. mori larvae using geNorm and NormFinder. The results revealed that, using the combination of the expression of BGIBMGA003186 and BGIBMGA008209 was the optimum choice for normalizing the expression data of the B. mori tissue/organ samples. The most stable gene, BGIBMGA003186, is recommended if just one reference gene is used. Moreover, the commonly used reference gene encoding cytoplasmic actin was the least appropriate reference gene of the samples investigated. The reliability of the selected reference genes was further confirmed by evaluating the expression profiles of two cathepsin genes. Our results may be useful for future studies involving the quantification of relative gene expression levels of different tissue/organ samples in B. mori. © 2018 Wiley Periodicals, Inc.

  18. Evaluation of candidate reference genes for normalization of quantitative RT-PCR in soybean tissues under various abiotic stress conditions.

    Directory of Open Access Journals (Sweden)

    Dung Tien Le

    Full Text Available Quantitative RT-PCR can be a very sensitive and powerful technique for measuring differential gene expression. Changes in gene expression induced by abiotic stresses are complex and multifaceted, which make determining stably expressed genes for data normalization difficult. To identify the most suitable reference genes for abiotic stress studies in soybean, 13 candidate genes collected from literature were evaluated for stability of expression under dehydration, high salinity, cold and ABA (abscisic acid treatments using delta CT and geNorm approaches. Validation of reference genes indicated that the best reference genes are tissue- and stress-dependent. With respect to dehydration treatment, the Fbox/ABC, Fbox/60s gene pairs were found to have the highest expression stability in the root and shoot tissues of soybean seedlings, respectively. Fbox and 60s genes are the most suitable reference genes across dehydrated root and shoot tissues. Under salt stress the ELF1b/IDE and Fbox/ELF1b are the most stably expressed gene pairs in roots and shoots, respectively, while 60s/Fbox is the best gene pair in both tissues. For studying cold stress in roots or shoots, IDE/60s and Fbox/Act27 are good reference gene pairs, respectively. With regard to gene expression analysis under ABA treatment in either roots, shoots or across these tissues, 60s/ELF1b, ELF1b/Fbox and 60s/ELF1b are the most suitable reference genes, respectively. The expression of ELF1b/60s, 60s/Fbox and 60s/Fbox genes was most stable in roots, shoots and both tissues, respectively, under various stresses studied. Among the genes tested, 60s was found to be the best reference gene in different tissues and under various stress conditions. The highly ranked reference genes identified from this study were proved to be capable of detecting subtle differences in expression rates that otherwise would be missed if a less stable reference gene was used.

  19. Validation of potential reference genes for qPCR in maize across abiotic stresses, hormone treatments, and tissue types.

    Directory of Open Access Journals (Sweden)

    Yueai Lin

    Full Text Available The reverse transcription quantitative polymerase chain reaction (RT-qPCR is a powerful and widely used technique for the measurement of gene expression. Reference genes, which serve as endogenous controls ensure that the results are accurate and reproducible, are vital for data normalization. To bolster the literature on reference gene selection in maize, ten candidate reference genes, including eight traditionally used internal control genes and two potential candidate genes from our microarray datasets, were evaluated for expression level in maize across abiotic stresses (cold, heat, salinity, and PEG, phytohormone treatments (abscisic acid, salicylic acid, jasmonic acid, ethylene, and gibberellins, and different tissue types. Three analytical software packages, geNorm, NormFinder, and Bestkeeper, were used to assess the stability of reference gene expression. The results revealed that elongation factor 1 alpha (EF1α, tubulin beta (β-TUB, cyclophilin (CYP, and eukaryotic initiation factor 4A (EIF4A were the most reliable reference genes for overall gene expression normalization in maize, while GRP (Glycine-rich RNA-binding protein, GLU1(beta-glucosidase, and UBQ9 (ubiquitin 9 were the least stable and most unsuitable genes. In addition, the suitability of EF1α, β-TUB, and their combination as reference genes was confirmed by validating the expression of WRKY50 in various samples. The current study indicates the appropriate reference genes for the urgent requirement of gene expression normalization in maize across certain abiotic stresses, hormones, and tissue types.

  20. Certification of methylmercury content in two fresh-frozen reference materials: SRM 1947 Lake Michigan fish tissue and SRM 1974b organics in mussel tissue (Mytilus edulis)

    International Nuclear Information System (INIS)

    Davis, W.C.; Christopher, S.J.; Pugh, Rebecca S.; Donard, O.F.X.; Krupp, Eva A.; Point, David; Horvat, Milena; Gibicar, D.; Kljakovic-Gaspic, Z.; Porter, Barbara J.; Schantz, Michele M.

    2007-01-01

    This paper describes the development of two independent analytical methods for the extraction and quantification of methylmercury from marine biota. The procedures involve microwave extraction, followed by derivatization and either headspace solid-phase microextraction (SPME) with a polydimethylsiloxane (PDMS)-coated silica fiber or back-extraction into iso-octane. The identification and quantification of the extracted compounds is carried out by capillary gas chromatography/mass spectrometric (GC/MS) and inductively coupled plasma mass spectrometric (GC/ICP-MS) detection. Both methods were validated for the determination of methylmercury (MeHg) concentrations in a variety of biological standard reference materials (SRMs) including fresh-frozen tissue homogenates of SRM 1946 Lake Superior fish tissue and SRM 1974a organics in mussel tissue (Mytilus edulis) and then applied to the certification effort of SRM 1947 Lake Michigan fish tissue and SRM 1974b organics in mussel tissue (Mytilus edulis). While past certifications of methylmercury in tissue SRMs have been based on two independent methods from the National Institute of Standards and Technology (NIST) and participating laboratories, the methods described within provide improved protocols and will allow future certification efforts to be based on at least two independent analytical methods within NIST. (orig.)

  1. Certification of methylmercury content in two fresh-frozen reference materials: SRM 1947 Lake Michigan fish tissue and SRM 1974b organics in mussel tissue (Mytilus edulis)

    Energy Technology Data Exchange (ETDEWEB)

    Davis, W.C.; Christopher, S.J.; Pugh, Rebecca S. [National Institute of Standards and Technology (NIST), Hollings Marine Laboratory, Analytical Chemistry Division, Charleston, SC (United States); Donard, O.F.X.; Krupp, Eva A. [LCABIE/CNRS Helioparc Pau-Pyrenees, Pau (France); Point, David [National Institute of Standards and Technology (NIST), Hollings Marine Laboratory, Analytical Chemistry Division, Charleston, SC (United States); LCABIE/CNRS Helioparc Pau-Pyrenees, Pau (France); Horvat, Milena; Gibicar, D. [Jozef Stefan Institute, Ljubljana (Slovenia); Kljakovic-Gaspic, Z. [Jozef Stefan Institute, Ljubljana (Slovenia); Institute for Medical Research and Occupational Health, Zagreb (Croatia); Porter, Barbara J.; Schantz, Michele M. [National Institute of Standards and Technology (NIST), Analytical Chemistry Division, Gaithersburg, MD (United States)

    2007-04-15

    This paper describes the development of two independent analytical methods for the extraction and quantification of methylmercury from marine biota. The procedures involve microwave extraction, followed by derivatization and either headspace solid-phase microextraction (SPME) with a polydimethylsiloxane (PDMS)-coated silica fiber or back-extraction into iso-octane. The identification and quantification of the extracted compounds is carried out by capillary gas chromatography/mass spectrometric (GC/MS) and inductively coupled plasma mass spectrometric (GC/ICP-MS) detection. Both methods were validated for the determination of methylmercury (MeHg) concentrations in a variety of biological standard reference materials (SRMs) including fresh-frozen tissue homogenates of SRM 1946 Lake Superior fish tissue and SRM 1974a organics in mussel tissue (Mytilus edulis) and then applied to the certification effort of SRM 1947 Lake Michigan fish tissue and SRM 1974b organics in mussel tissue (Mytilus edulis). While past certifications of methylmercury in tissue SRMs have been based on two independent methods from the National Institute of Standards and Technology (NIST) and participating laboratories, the methods described within provide improved protocols and will allow future certification efforts to be based on at least two independent analytical methods within NIST. (orig.)

  2. A theoretical analysis of damage evolution in skeletal muscle tissue with reference to pressure ulcer development

    NARCIS (Netherlands)

    Breuls, R.G.M.; Bouten, C.V.C.; Oomens, C.W.J.; Bader, D.L.; Baaijens, F.P.T.

    2003-01-01

    Soft tissues are sensitive to prolonged compressive loading, eventually leading to tissue necrosis in the form of pressure ulcers [1]. Pressure ulcers can occur in situations where people are subjected to sustained mechanical loads, such as when bedridden, sitting in a wheelchair or from wearing

  3. Machine learning-based dual-energy CT parametric mapping.

    Science.gov (United States)

    Su, Kuan-Hao; Kuo, Jung-Wen; Jordan, David W; Van Hedent, Steven; Klahr, Paul; Wei, Zhouping; Al Helo, Rose; Liang, Fan; Qian, Pengjiang; Pereira, Gisele C; Rassouli, Negin; Gilkeson, Robert C; Traughber, Bryan J; Cheng, Chee-Wai; Muzic, Raymond F

    2018-05-22

    The aim is to develop and evaluate machine learning methods for generating quantitative parametric maps of effective atomic number (Zeff), relative electron density (ρe), mean excitation energy (Ix), and relative stopping power (RSP) from clinical dual-energy CT data. The maps could be used for material identification and radiation dose calculation. Machine learning methods of historical centroid (HC), random forest (RF), and artificial neural networks (ANN) were used to learn the relationship between dual-energy CT input data and ideal output parametric maps calculated for phantoms from the known compositions of 13 tissue substitutes. After training and model selection steps, the machine learning predictors were used to generate parametric maps from independent phantom and patient input data. Precision and accuracy were evaluated using the ideal maps. This process was repeated for a range of exposure doses, and performance was compared to that of the clinically-used dual-energy, physics-based method which served as the reference. The machine learning methods generated more accurate and precise parametric maps than those obtained using the reference method. Their performance advantage was particularly evident when using data from the lowest exposure, one-fifth of a typical clinical abdomen CT acquisition. The RF method achieved the greatest accuracy. In comparison, the ANN method was only 1% less accurate but had much better computational efficiency than RF, being able to produce parametric maps in 15 seconds. Machine learning methods outperformed the reference method in terms of accuracy and noise tolerance when generating parametric maps, encouraging further exploration of the techniques. Among the methods we evaluated, ANN is the most suitable for clinical use due to its combination of accuracy, excellent low-noise performance, and computational efficiency. . © 2018 Institute of Physics and Engineering in

  4. Equilibrium Passive Sampling of POP in Lipid-Rich and Lean Fish Tissue: Quality Control Using Performance Reference Compounds.

    Science.gov (United States)

    Rusina, Tatsiana P; Carlsson, Pernilla; Vrana, Branislav; Smedes, Foppe

    2017-10-03

    Passive sampling is widely used to measure levels of contaminants in various environmental matrices, including fish tissue. Equilibrium passive sampling (EPS) of persistent organic pollutants (POP) in fish tissue has been hitherto limited to application in lipid-rich tissue. We tested several exposure methods to extend EPS applicability to lean tissue. Thin-film polydimethylsiloxane (PDMS) passive samplers were exposed statically to intact fillet and fish homogenate and dynamically by rolling with cut fillet cubes. The release of performance reference compounds (PRC) dosed to passive samplers prior to exposure was used to monitor the exchange process. The sampler-tissue exchange was isotropic, and PRC were shown to be good indicators of sampler-tissue equilibration status. The dynamic exposures demonstrated equilibrium attainment in less than 2 days for all three tested fish species, including lean fish containing 1% lipid. Lipid-based concentrations derived from EPS were in good agreement with lipid-normalized concentrations obtained using conventional solvent extraction. The developed in-tissue EPS method is robust and has potential for application in chemical monitoring of biota and bioaccumulation studies.

  5. On fibrinolytic phenomenon in the cancerous tissue of cervical carcinoma with special reference to irradiation changes

    International Nuclear Information System (INIS)

    Nakamura, Kazuyoshi

    1978-01-01

    In a study undertaken to investigate alterations of fibrinolytic enzymes in cancerous tissue of the cervix under radiotherapy, specimens were taken from malignant tissues of cervical cancer patients during irradiation therapy with Linac x-ray at 1000, 2000 and 3000 rads and were subsequently assayed for fibrinolytic enzyme activities using the fibrin plate method. No plasmin activity was demonstrable in the normal mucosa of the uterine cervix. Cancerous tissue of the uterine cervix also showed no demonstrable plasmin activity. The malignant tissue, as compared to the normal mucosa of the cervix, was found to have a lower activator activity, a higher proactivator activity and lower activities of both antiplasmin inhibitors. During radiotherapy for cervical cancer, plasmin activity was demonstrable in the cancerous tissue and in patients with malignant neoplasm, demonstrating that plasmin activity increased as the radiation dose was increased. A relationship seemed to exist between morphological changes and alterations in the fibrinolytic system of cancerous tissue of the cervix. From these findings it seems that the altered fibrinolytic enzyme system in cancerous tissue may have a close relationship with the growth and development of malignancy and may also have an important role in the occurrence of metastasis. There were some cases, in which an abnormal increase in activator activity occurred during irradiation therapy, leading to the death of the patients. This fact points to the possibility that activator activity might provide a useful index for evaluating the prognosis of cervical cancer. (author)

  6. Evaluation of reference genes for quantitative real-time PCR in oil palm elite planting materials propagated by tissue culture.

    Directory of Open Access Journals (Sweden)

    Pek-Lan Chan

    Full Text Available BACKGROUND: The somatic embryogenesis tissue culture process has been utilized to propagate high yielding oil palm. Due to the low callogenesis and embryogenesis rates, molecular studies were initiated to identify genes regulating the process, and their expression levels are usually quantified using reverse transcription quantitative real-time PCR (RT-qPCR. With the recent release of oil palm genome sequences, it is crucial to establish a proper strategy for gene analysis using RT-qPCR. Selection of the most suitable reference genes should be performed for accurate quantification of gene expression levels. RESULTS: In this study, eight candidate reference genes selected from cDNA microarray study and literature review were evaluated comprehensively across 26 tissue culture samples using RT-qPCR. These samples were collected from two tissue culture lines and media treatments, which consisted of leaf explants cultures, callus and embryoids from consecutive developmental stages. Three statistical algorithms (geNorm, NormFinder and BestKeeper confirmed that the expression stability of novel reference genes (pOP-EA01332, PD00380 and PD00569 outperformed classical housekeeping genes (GAPDH, NAD5, TUBULIN, UBIQUITIN and ACTIN. PD00380 and PD00569 were identified as the most stably expressed genes in total samples, MA2 and MA8 tissue culture lines. Their applicability to validate the expression profiles of a putative ethylene-responsive transcription factor 3-like gene demonstrated the importance of using the geometric mean of two genes for normalization. CONCLUSIONS: Systematic selection of the most stably expressed reference genes for RT-qPCR was established in oil palm tissue culture samples. PD00380 and PD00569 were selected for accurate and reliable normalization of gene expression data from RT-qPCR. These data will be valuable to the research associated with the tissue culture process. Also, the method described here will facilitate the selection

  7. Evaluation of Reference Genes for Quantitative Real-Time PCR in Oil Palm Elite Planting Materials Propagated by Tissue Culture

    Science.gov (United States)

    Chan, Pek-Lan; Rose, Ray J.; Abdul Murad, Abdul Munir; Zainal, Zamri; Leslie Low, Eng-Ti; Ooi, Leslie Cheng-Li; Ooi, Siew-Eng; Yahya, Suzaini; Singh, Rajinder

    2014-01-01

    Background The somatic embryogenesis tissue culture process has been utilized to propagate high yielding oil palm. Due to the low callogenesis and embryogenesis rates, molecular studies were initiated to identify genes regulating the process, and their expression levels are usually quantified using reverse transcription quantitative real-time PCR (RT-qPCR). With the recent release of oil palm genome sequences, it is crucial to establish a proper strategy for gene analysis using RT-qPCR. Selection of the most suitable reference genes should be performed for accurate quantification of gene expression levels. Results In this study, eight candidate reference genes selected from cDNA microarray study and literature review were evaluated comprehensively across 26 tissue culture samples using RT-qPCR. These samples were collected from two tissue culture lines and media treatments, which consisted of leaf explants cultures, callus and embryoids from consecutive developmental stages. Three statistical algorithms (geNorm, NormFinder and BestKeeper) confirmed that the expression stability of novel reference genes (pOP-EA01332, PD00380 and PD00569) outperformed classical housekeeping genes (GAPDH, NAD5, TUBULIN, UBIQUITIN and ACTIN). PD00380 and PD00569 were identified as the most stably expressed genes in total samples, MA2 and MA8 tissue culture lines. Their applicability to validate the expression profiles of a putative ethylene-responsive transcription factor 3-like gene demonstrated the importance of using the geometric mean of two genes for normalization. Conclusions Systematic selection of the most stably expressed reference genes for RT-qPCR was established in oil palm tissue culture samples. PD00380 and PD00569 were selected for accurate and reliable normalization of gene expression data from RT-qPCR. These data will be valuable to the research associated with the tissue culture process. Also, the method described here will facilitate the selection of appropriate

  8. Referred pain and cutaneous responses from deep tissue electrical pain stimulation in the groin

    DEFF Research Database (Denmark)

    Aasvang, E K; Werner, M U; Kehlet, H

    2015-01-01

    , supporting individual differences in anatomy and sensory processing. Future studies investigating the responses to deep tissue electrical stimulation in persistent postherniotomy pain patients may advance our understanding of underlying pathophysiological mechanisms and strategies for treatment...

  9. Histopathological diagnostic discrepancies in soft tissue tumours referred to a specialist centre: reassessment in the era of ancillary molecular diagnosis.

    Science.gov (United States)

    Thway, Khin; Wang, Jayson; Mubako, Taka; Fisher, Cyril

    2014-01-01

    Introduction. Soft tissue tumour pathology is a highly specialised area of surgical pathology, but soft tissue neoplasms can occur at virtually all sites and are therefore encountered by a wide population of surgical pathologists. Potential sarcomas require referral to specialist centres for review by pathologists who see a large number of soft tissue lesions and where appropriate ancillary investigations can be performed. We have previously assessed the types of diagnostic discrepancies between referring and final diagnosis for soft tissue lesions referred to our tertiary centre. We now reaudit this 6 years later, assessing changes in discrepancy patterns, particularly in relation to the now widespread use of ancillary molecular diagnostic techniques which were not prevalent in our original study. Materials and Methods. We compared the sarcoma unit's histopathology reports with referring reports on 348 specimens from 286 patients with suspected or proven soft tissue tumours in a one-year period. Results. Diagnostic agreement was seen in 250 cases (71.8%), with 57 (16.4%) major and 41 (11.8%) minor discrepancies. There were 23 cases of benign/malignant discrepancies (23.5% of all discrepancies). 50 ancillary molecular tests were performed, 33 for aiding diagnosis and 17 mutational analyses for gastrointestinal stromal tumour to guide therapy. Findings from ancillary techniques contributed to 3 major and 4 minor discrepancies. While the results were broadly similar to those of the previous study, there was an increase in frequency of major discrepancies. Conclusion. Six years following our previous study and notably now in an era of widespread ancillary molecular diagnosis, the overall discrepancy rate between referral and tertiary centre diagnosis remains similar, but there is an increase in frequency of major discrepancies likely to alter patient management. A possible reason for the increase in major discrepancies is the increasing lack of exposure to soft tissue

  10. Reference-free determination of tissue absorption coefficient by modulation transfer function characterization in spatial frequency domain.

    Science.gov (United States)

    Chen, Weiting; Zhao, Huijuan; Li, Tongxin; Yan, Panpan; Zhao, Kuanxin; Qi, Caixia; Gao, Feng

    2017-08-08

    Spatial frequency domain (SFD) measurement allows rapid and non-contact wide-field imaging of the tissue optical properties, thus has become a potential tool for assessing physiological parameters and therapeutic responses during photodynamic therapy of skin diseases. The conventional SFD measurement requires a reference measurement within the same experimental scenario as that for a test one to calibrate mismatch between the real measurements and the model predictions. Due to the individual physical and geometrical differences among different tissues, organs and patients, an ideal reference measurement might be unavailable in clinical trials. To address this problem, we present a reference-free SFD determination of absorption coefficient that is based on the modulation transfer function (MTF) characterization. Instead of the absolute amplitude that is used in the conventional SFD approaches, we herein employ the MTF to characterize the propagation of the modulated lights in tissues. With such a dimensionless relative quantity, the measurements can be naturally corresponded to the model predictions without calibrating the illumination intensity. By constructing a three-dimensional database that portrays the MTF as a function of the optical properties (both the absorption coefficient μ a and the reduced scattering coefficient [Formula: see text]) and the spatial frequency, a look-up table approach or a least-square curve-fitting method is readily applied to recover the absorption coefficient from a single frequency or multiple frequencies, respectively. Simulation studies have verified the feasibility of the proposed reference-free method and evaluated its accuracy in the absorption recovery. Experimental validations have been performed on homogeneous tissue-mimicking phantoms with μ a ranging from 0.01 to 0.07 mm -1 and [Formula: see text] = 1.0 or 2.0 mm -1 . The results have shown maximum errors of 4.86 and 7% for [Formula: see text] = 1.0 mm -1 and

  11. Relational Parametricity and Separation Logic

    DEFF Research Database (Denmark)

    Birkedal, Lars; Yang, Hongseok

    2008-01-01

    Separation logic is a recent extension of Hoare logic for reasoning about programs with references to shared mutable data structures. In this paper, we provide a new interpretation of the logic for a programming language with higher types. Our interpretation is based on Reynolds's relational...... parametricity, and it provides a formal connection between separation logic and data abstraction. Udgivelsesdato: 2008...

  12. Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR

    DEFF Research Database (Denmark)

    Hillig, Ann-Britt Nygaard; Jørgensen, Claus Bøttcher; Cirera, Susanna

    2007-01-01

    -microglobulin (B2M), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), hydroxymethylbilane synthase (HMBS), hypoxanthine phosphoribosyltransferase I (HPRT I), ribosomal protein L4 (RPL4), succinate dehydrogenase complex subunit A (SDHA), TATA box binding protein (TPB) and tyrosine 3-monooxygenase/tryptophan 5......-monooxygenase activation protein zeta polypeptide (YWHAZ). The stability of these reference genes in different pig tissues was investigated using the geNorm application. The range of expression stability in the genes analysed was (from the most stable to the least stable): ACTB/RPL4, TBP, HPRT, HMBS, YWHAZ...

  13. Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue

    Directory of Open Access Journals (Sweden)

    Ravid Rivka

    2008-05-01

    Full Text Available Abstract Background Studies of gene expression in post mortem human brain can contribute to understanding of the pathophysiology of neurodegenerative diseases, including Alzheimer's disease (AD, Parkinson's disease (PD and dementia with Lewy bodies (DLB. Quantitative real-time PCR (RT qPCR is often used to analyse gene expression. The validity of results obtained using RT qPCR is reliant on accurate data normalization. Reference genes are generally used to normalize RT qPCR data. Given that expression of some commonly used reference genes is altered in certain conditions, this study aimed to establish which reference genes were stably expressed in post mortem brain tissue from individuals with AD, PD or DLB. Results The present study investigated the expression stability of 8 candidate reference genes, (ubiquitin C [UBC], tyrosine-3-monooxygenase [YWHAZ], RNA polymerase II polypeptide [RP II], hydroxymethylbilane synthase [HMBS], TATA box binding protein [TBP], β-2-microglobulin [B2M], glyceraldehyde-3-phosphate dehydrogenase [GAPDH], and succinate dehydrogenase complex-subunit A, [SDHA] in cerebellum and medial temporal gyrus of 6 AD, 6 PD, 6 DLB subjects, along with 5 matched controls using RT qPCR (TaqMan® Gene Expression Assays. Gene expression stability was analysed using geNorm to rank the candidate genes in order of decreasing stability in each disease group. The optimal number of genes recommended for accurate data normalization in each disease state was determined by pairwise variation analysis. Conclusion This study identified validated sets of mRNAs which would be appropriate for the normalization of RT qPCR data when studying gene expression in brain tissue of AD, PD, DLB and control subjects.

  14. Identification of Reference Genes for Quantitative Real Time PCR Assays in Aortic Tissue of Syrian Hamsters with Bicuspid Aortic Valve.

    Science.gov (United States)

    Rueda-Martínez, Carmen; Fernández, M Carmen; Soto-Navarrete, María Teresa; Jiménez-Navarro, Manuel; Durán, Ana Carmen; Fernández, Borja

    2016-01-01

    Bicuspid aortic valve (BAV) is the most frequent congenital cardiac malformation in humans, and appears frequently associated with dilatation of the ascending aorta. This association is likely the result of a common aetiology. Currently, a Syrian hamster strain with a relatively high (∼40%) incidence of BAV constitutes the only spontaneous animal model of BAV disease. The characterization of molecular alterations in the aorta of hamsters with BAV may serve to identify pathophysiological mechanisms and molecular markers of disease in humans. In this report, we evaluate the expression of ten candidate reference genes in aortic tissue of hamsters in order to identify housekeeping genes for normalization using quantitative real time PCR (RT-qPCR) assays. A total of 51 adult (180-240 days old) and 56 old (300-440 days old) animals were used. They belonged to a control strain of hamsters with normal, tricuspid aortic valve (TAV; n = 30), or to the affected strain of hamsters with TAV (n = 45) or BAV (n = 32). The expression stability of the candidate reference genes was determined by RT-qPCR using three statistical algorithms, GeNorm, NormFinder and Bestkeeper. The expression analyses showed that the most stable reference genes for the three algorithms employed were Cdkn1β, G3pdh and Polr2a. We propose the use of Cdkn1β, or both Cdkn1β and G3pdh as reference genes for mRNA expression analyses in Syrian hamster aorta.

  15. Identification of Reference Genes for Quantitative Real Time PCR Assays in Aortic Tissue of Syrian Hamsters with Bicuspid Aortic Valve.

    Directory of Open Access Journals (Sweden)

    Carmen Rueda-Martínez

    Full Text Available Bicuspid aortic valve (BAV is the most frequent congenital cardiac malformation in humans, and appears frequently associated with dilatation of the ascending aorta. This association is likely the result of a common aetiology. Currently, a Syrian hamster strain with a relatively high (∼40% incidence of BAV constitutes the only spontaneous animal model of BAV disease. The characterization of molecular alterations in the aorta of hamsters with BAV may serve to identify pathophysiological mechanisms and molecular markers of disease in humans. In this report, we evaluate the expression of ten candidate reference genes in aortic tissue of hamsters in order to identify housekeeping genes for normalization using quantitative real time PCR (RT-qPCR assays. A total of 51 adult (180-240 days old and 56 old (300-440 days old animals were used. They belonged to a control strain of hamsters with normal, tricuspid aortic valve (TAV; n = 30, or to the affected strain of hamsters with TAV (n = 45 or BAV (n = 32. The expression stability of the candidate reference genes was determined by RT-qPCR using three statistical algorithms, GeNorm, NormFinder and Bestkeeper. The expression analyses showed that the most stable reference genes for the three algorithms employed were Cdkn1β, G3pdh and Polr2a. We propose the use of Cdkn1β, or both Cdkn1β and G3pdh as reference genes for mRNA expression analyses in Syrian hamster aorta.

  16. Parametric and Non-Parametric System Modelling

    DEFF Research Database (Denmark)

    Nielsen, Henrik Aalborg

    1999-01-01

    the focus is on combinations of parametric and non-parametric methods of regression. This combination can be in terms of additive models where e.g. one or more non-parametric term is added to a linear regression model. It can also be in terms of conditional parametric models where the coefficients...... considered. It is shown that adaptive estimation in conditional parametric models can be performed by combining the well known methods of local polynomial regression and recursive least squares with exponential forgetting. The approach used for estimation in conditional parametric models also highlights how...... networks is included. In this paper, neural networks are used for predicting the electricity production of a wind farm. The results are compared with results obtained using an adaptively estimated ARX-model. Finally, two papers on stochastic differential equations are included. In the first paper, among...

  17. Preparation, characterization and use of a reference material to proficiency testing for determination of metals in fish tissue in natura

    International Nuclear Information System (INIS)

    Santana, Luciana Vieira de

    2013-01-01

    The proficiency tests are widely used to evaluate the analytical capacity of laboratories and also as part of the accreditation process. For this reason, are important tools for the control of the quality of the analytical results obtained in the laboratories that work directly with seafood companies. In Brazil there are no providers of proficiency testing for metals potentially toxic in fish tissues. In this work will be described all steps used for the production of reference materials to be used in a proficiency testing pilot study for As, Cd, Pb and Hg in fish tissue following the recommendations of the ISO Guide 35. He preparation scheme consisted in selecting the individuals, cleaning, grinding, homogenization and fortification with As, Cd and Pb in two concentration levels. The preparation resulted in 164 sachets of 10 g each. In order to evaluate the effect of gamma irradiation in the samples conservation 52 sachets were irradiated with 60 Co (10.00 ± 1.05 kGy) in a gamma cell. This material with others non irradiated 52 sachets were used for the homogeneity and stability studies. The remaining 60 were used for the proficiency testing. The results demonstrated that both materials were homogeneous and presented good stability (during a period of 45 days). However, the irradiated material present better integrity, concerning biological degradation, when stored in ambient temperature. For this reason they were used to the proficiency testing pilot program. Ten laboratories participated in the proficiency testing pilot study and the results were evaluated using the following tests: z-score, confidence ellipse and En numbers. This work demonstrates the capability of the laboratory to produce reference materials as well as to organize and conduct proficiency testing. (author)

  18. Effect of sample size on multi-parametric prediction of tissue outcome in acute ischemic stroke using a random forest classifier

    Science.gov (United States)

    Forkert, Nils Daniel; Fiehler, Jens

    2015-03-01

    The tissue outcome prediction in acute ischemic stroke patients is highly relevant for clinical and research purposes. It has been shown that the combined analysis of diffusion and perfusion MRI datasets using high-level machine learning techniques leads to an improved prediction of final infarction compared to single perfusion parameter thresholding. However, most high-level classifiers require a previous training and, until now, it is ambiguous how many subjects are required for this, which is the focus of this work. 23 MRI datasets of acute stroke patients with known tissue outcome were used in this work. Relative values of diffusion and perfusion parameters as well as the binary tissue outcome were extracted on a voxel-by- voxel level for all patients and used for training of a random forest classifier. The number of patients used for training set definition was iteratively and randomly reduced from using all 22 other patients to only one other patient. Thus, 22 tissue outcome predictions were generated for each patient using the trained random forest classifiers and compared to the known tissue outcome using the Dice coefficient. Overall, a logarithmic relation between the number of patients used for training set definition and tissue outcome prediction accuracy was found. Quantitatively, a mean Dice coefficient of 0.45 was found for the prediction using the training set consisting of the voxel information from only one other patient, which increases to 0.53 if using all other patients (n=22). Based on extrapolation, 50-100 patients appear to be a reasonable tradeoff between tissue outcome prediction accuracy and effort required for data acquisition and preparation.

  19. Structural organization of the thyroid gland and interrenal tissue with reference to endocrine parenchyma in short mackerel, Rastrelliger brachysoma (Bleeker, 1851

    Directory of Open Access Journals (Sweden)

    Sinlapachai Senarat

    2016-01-01

    Full Text Available The first investigations of the thyroid gland and interrenal tissue with reference to the endocrine parenchyma of short mackerel Rastrelliger brachysoma were subjected to histological analysis. Specimens were collected during the fishing season (October to November 2013 from the Upper Gulf of Thailand. Under a light microscope, the thyroid gland of R. brachysoma was distinctly found located within the branchial region. Within this gland, it consists of several follicles among afferent brachial arteries. Each follicle exclusively contained a colloid that was surrounded by a simple, cuboidal, follicle epithelium. Histological study showed that the localization of interrenal tissue was in the anterior kidney. This tissue was composed of two parts based on the structural compositions and cell types; (i the stromal compartment was constituted of various interrenal cells and (ii the interstitial compartment contained the connective tissue, leucocytes and blood sinuses, with reference to the lymphatic tissue.

  20. On Parametric (and Non-Parametric Variation

    Directory of Open Access Journals (Sweden)

    Neil Smith

    2009-11-01

    Full Text Available This article raises the issue of the correct characterization of ‘Parametric Variation’ in syntax and phonology. After specifying their theoretical commitments, the authors outline the relevant parts of the Principles–and–Parameters framework, and draw a three-way distinction among Universal Principles, Parameters, and Accidents. The core of the contribution then consists of an attempt to provide identity criteria for parametric, as opposed to non-parametric, variation. Parametric choices must be antecedently known, and it is suggested that they must also satisfy seven individually necessary and jointly sufficient criteria. These are that they be cognitively represented, systematic, dependent on the input, deterministic, discrete, mutually exclusive, and irreversible.

  1. Selection of suitable reference genes for normalization of genes of interest in canine soft tissue sarcomas using quantitative real-time polymerase chain reaction

    DEFF Research Database (Denmark)

    Zornhagen, K. W.; Kristensen, A. T.; Hansen, Anders Elias

    2015-01-01

    Quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) is a sensitive technique for quantifying gene expression. Stably expressed reference genes are necessary for normalization of RT-qPCR data. Only a few articles have been published on reference genes in canine tumours....... The objective of this study was to demonstrate how to identify suitable reference genes for normalization of genes of interest in canine soft tissue sarcomas using RT-qPCR. Primer pairs for 17 potential reference genes were designed and tested in archival tumour biopsies from six dogs. The geNorm algorithm...

  2. Tissue

    Directory of Open Access Journals (Sweden)

    David Morrissey

    2012-01-01

    Full Text Available Purpose. In vivo gene therapy directed at tissues of mesenchymal origin could potentially augment healing. We aimed to assess the duration and magnitude of transene expression in vivo in mice and ex vivo in human tissues. Methods. Using bioluminescence imaging, plasmid and adenoviral vector-based transgene expression in murine quadriceps in vivo was examined. Temporal control was assessed using a doxycycline-inducible system. An ex vivo model was developed and optimised using murine tissue, and applied in ex vivo human tissue. Results. In vivo plasmid-based transgene expression did not silence in murine muscle, unlike in liver. Although maximum luciferase expression was higher in muscle with adenoviral delivery compared with plasmid, expression reduced over time. The inducible promoter cassette successfully regulated gene expression with maximum levels a factor of 11 greater than baseline. Expression was re-induced to a similar level on a temporal basis. Luciferase expression was readily detected ex vivo in human muscle and tendon. Conclusions. Plasmid constructs resulted in long-term in vivo gene expression in skeletal muscle, in a controllable fashion utilising an inducible promoter in combination with oral agents. Successful plasmid gene transfection in human ex vivo mesenchymal tissue was demonstrated for the first time.

  3. Validation of reference genes for gene expression analysis in olive (Olea europaea) mesocarp tissue by quantitative real-time RT-PCR

    Science.gov (United States)

    2014-01-01

    Background Gene expression analysis using quantitative reverse transcription PCR (qRT-PCR) is a robust method wherein the expression levels of target genes are normalised using internal control genes, known as reference genes, to derive changes in gene expression levels. Although reference genes have recently been suggested for olive tissues, combined/independent analysis on different cultivars has not yet been tested. Therefore, an assessment of reference genes was required to validate the recent findings and select stably expressed genes across different olive cultivars. Results A total of eight candidate reference genes [glyceraldehyde 3-phosphate dehydrogenase (GAPDH), serine/threonine-protein phosphatase catalytic subunit (PP2A), elongation factor 1 alpha (EF1-alpha), polyubiquitin (OUB2), aquaporin tonoplast intrinsic protein (TIP2), tubulin alpha (TUBA), 60S ribosomal protein L18-3 (60S RBP L18-3) and polypyrimidine tract-binding protein homolog 3 (PTB)] were chosen based on their stability in olive tissues as well as in other plants. Expression stability was examined by qRT-PCR across 12 biological samples, representing mesocarp tissues at various developmental stages in three different olive cultivars, Barnea, Frantoio and Picual, independently and together during the 2009 season with two software programs, GeNorm and BestKeeper. Both software packages identified GAPDH, EF1-alpha and PP2A as the three most stable reference genes across the three cultivars and in the cultivar, Barnea. GAPDH, EF1-alpha and 60S RBP L18-3 were found to be most stable reference genes in the cultivar Frantoio while 60S RBP L18-3, OUB2 and PP2A were found to be most stable reference genes in the cultivar Picual. Conclusions The analyses of expression stability of reference genes using qRT-PCR revealed that GAPDH, EF1-alpha, PP2A, 60S RBP L18-3 and OUB2 are suitable reference genes for expression analysis in developing Olea europaea mesocarp tissues, displaying the highest level

  4. Certification of methylmercury in cod fish tissue certified reference material by species-specific isotope dilution mass spectrometric analysis

    Energy Technology Data Exchange (ETDEWEB)

    Inagaki, Kazumi; Kuroiwa, Takayoshi; Narukawa, Tomohiro; Yarita, Takashi; Takatsu, Akiko; Okamoto, Kensaku; Chiba, Koichi [National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), Environmental Standard Section, Tsukuba, Ibaraki (Japan)

    2008-07-15

    A new cod fish tissue certified reference material, NMIJ CRM 7402-a, for methylmercury analysis was certified by the National Metrological Institute of Japan in the National Institute of Advanced Industrial Science and Technology (NMIJ/AIST). Cod fish was collected from the sea close to Japan. The cod muscle was powdered by freeze-pulverization and was placed into 600 glass bottles (10 g each), which were sterilized with {gamma}-ray irradiation. The certification was carried out using species-specific isotope dilution gas chromatography inductively coupled plasma mass spectrometry (SSID-GC-ICPMS), where {sup 202}Hg-enriched methylmercury (MeHg) was used as the spike compound. In order to avoid any possible analytical biases caused by nonquantitative extraction, degradation and/or formation of MeHg in sample preparations, two different extraction methods (KOH/methanol and HCl/methanol extractions) were performed, and one of these extraction methods utilized two different derivatization methods (ethylation and phenylation). A double ID method was adopted to minimize the uncertainty arising from the analyses. In order to ensure not only the reliability of the analytical results but also traceability to SI units, the standard solution of MeHg used for the reverse-ID was prepared from high-purity MeHg chloride and was carefully assayed as follows: the total mercury was determined by ID-ICPMS following aqua regia digestion, and the ratio of Hg as MeHg to the total Hg content was estimated by GC-ICPMS. The certified value given for MeHg is 0.58 {+-} 0.02 mg kg{sup -1} as Hg. (orig.)

  5. Selection of reference genes for quantitative RT-PCR (RT-qPCR) analysis of rat tissues under physiological and toxicological conditions

    DEFF Research Database (Denmark)

    Svingen, Terje; Letting, Heidi; Hadrup, Niels

    2015-01-01

    In biological research the analysis of gene expression levels in cells and tissues can be a powerful tool to gain insights into biological processes. For this, quantitative RT-PCR (RT-qPCR) is a popular method that often involve the use of constitutively expressed endogenous reference (or...... ‘housekeeping’) gene for normalization of data. Thus, it is essential to use reference genes that have been verified to be stably expressed within the specific experimental setting. Here, we have analysed the expression stability of 12 commonly used reference genes (Actb, B2m, Gapdh, Hprt, Pgk1, Rn18s, Rpl13a...

  6. Reference gene selection for quantitative gene expression studies during biological invasions: A test on multiple genes and tissues in a model ascidian Ciona savignyi.

    Science.gov (United States)

    Huang, Xuena; Gao, Yangchun; Jiang, Bei; Zhou, Zunchun; Zhan, Aibin

    2016-01-15

    As invasive species have successfully colonized a wide range of dramatically different local environments, they offer a good opportunity to study interactions between species and rapidly changing environments. Gene expression represents one of the primary and crucial mechanisms for rapid adaptation to local environments. Here, we aim to select reference genes for quantitative gene expression analysis based on quantitative Real-Time PCR (qRT-PCR) for a model invasive ascidian, Ciona savignyi. We analyzed the stability of ten candidate reference genes in three tissues (siphon, pharynx and intestine) under two key environmental stresses (temperature and salinity) in the marine realm based on three programs (geNorm, NormFinder and delta Ct method). Our results demonstrated only minor difference for stability rankings among the three methods. The use of different single reference gene might influence the data interpretation, while multiple reference genes could minimize possible errors. Therefore, reference gene combinations were recommended for different tissues - the optimal reference gene combination for siphon was RPS15 and RPL17 under temperature stress, and RPL17, UBQ and TubA under salinity treatment; for pharynx, TubB, TubA and RPL17 were the most stable genes under temperature stress, while TubB, TubA and UBQ were the best under salinity stress; for intestine, UBQ, RPS15 and RPL17 were the most reliable reference genes under both treatments. Our results suggest that the necessity of selection and test of reference genes for different tissues under varying environmental stresses. The results obtained here are expected to reveal mechanisms of gene expression-mediated invasion success using C. savignyi as a model species. Copyright © 2015 Elsevier B.V. All rights reserved.

  7. The use of laser microdissection in the identification of suitable reference genes for normalization of quantitative real-time PCR in human FFPE epithelial ovarian tissue samples.

    Directory of Open Access Journals (Sweden)

    Jing Cai

    Full Text Available Quantitative real-time PCR (qPCR is a powerful and reproducible method of gene expression analysis in which expression levels are quantified by normalization against reference genes. Therefore, to investigate the potential biomarkers and therapeutic targets for epithelial ovarian cancer by qPCR, it is critical to identify stable reference genes. In this study, twelve housekeeping genes (ACTB, GAPDH, 18S rRNA, GUSB, PPIA, PBGD, PUM1, TBP, HRPT1, RPLP0, RPL13A, and B2M were analyzed in 50 ovarian samples from normal, benign, borderline, and malignant tissues. For reliable results, laser microdissection (LMD, an effective technique used to prepare homogeneous starting material, was utilized to precisely excise target tissues or cells. One-way analysis of variance (ANOVA and nonparametric (Kruskal-Wallis tests were used to compare the expression differences. NormFinder and geNorm software were employed to further validate the suitability and stability of the candidate genes. Results showed that epithelial cells occupied a small percentage of the normal ovary indeed. The expression of ACTB, PPIA, RPL13A, RPLP0, and TBP were stable independent of the disease progression. In addition, NormFinder and geNorm identified the most stable combination (ACTB, PPIA, RPLP0, and TBP and the relatively unstable reference gene GAPDH from the twelve commonly used housekeeping genes. Our results highlight the use of homogeneous ovarian tissues and multiple-reference normalization strategy, e.g. the combination of ACTB, PPIA, RPLP0, and TBP, for qPCR in epithelial ovarian tissues, whereas GAPDH, the most commonly used reference gene, is not recommended, especially as a single reference gene.

  8. The use of laser microdissection in the identification of suitable reference genes for normalization of quantitative real-time PCR in human FFPE epithelial ovarian tissue samples.

    Science.gov (United States)

    Cai, Jing; Li, Tao; Huang, Bangxing; Cheng, Henghui; Ding, Hui; Dong, Weihong; Xiao, Man; Liu, Ling; Wang, Zehua

    2014-01-01

    Quantitative real-time PCR (qPCR) is a powerful and reproducible method of gene expression analysis in which expression levels are quantified by normalization against reference genes. Therefore, to investigate the potential biomarkers and therapeutic targets for epithelial ovarian cancer by qPCR, it is critical to identify stable reference genes. In this study, twelve housekeeping genes (ACTB, GAPDH, 18S rRNA, GUSB, PPIA, PBGD, PUM1, TBP, HRPT1, RPLP0, RPL13A, and B2M) were analyzed in 50 ovarian samples from normal, benign, borderline, and malignant tissues. For reliable results, laser microdissection (LMD), an effective technique used to prepare homogeneous starting material, was utilized to precisely excise target tissues or cells. One-way analysis of variance (ANOVA) and nonparametric (Kruskal-Wallis) tests were used to compare the expression differences. NormFinder and geNorm software were employed to further validate the suitability and stability of the candidate genes. Results showed that epithelial cells occupied a small percentage of the normal ovary indeed. The expression of ACTB, PPIA, RPL13A, RPLP0, and TBP were stable independent of the disease progression. In addition, NormFinder and geNorm identified the most stable combination (ACTB, PPIA, RPLP0, and TBP) and the relatively unstable reference gene GAPDH from the twelve commonly used housekeeping genes. Our results highlight the use of homogeneous ovarian tissues and multiple-reference normalization strategy, e.g. the combination of ACTB, PPIA, RPLP0, and TBP, for qPCR in epithelial ovarian tissues, whereas GAPDH, the most commonly used reference gene, is not recommended, especially as a single reference gene.

  9. Parametric Fires for Structural Design

    DEFF Research Database (Denmark)

    Hertz, Kristian

    2012-01-01

    The authorities, the construction association, and a number of companies in Denmark have supported the author writing a guide for design of building structures for parametric fires. The guide is published by the ministry as a supplement to the building regulations. However, consultants and contra......The authorities, the construction association, and a number of companies in Denmark have supported the author writing a guide for design of building structures for parametric fires. The guide is published by the ministry as a supplement to the building regulations. However, consultants...... and contractors have asked for a reference in English in order to make the guide-lines and the background for them available internationally. The paper therefore presents recommendations from the design guide especially concerning how to assess parametric design fires based on the opening factor method for large...... compartments. Findings leading to the guide-lines are discussed, and it is indicated what a safe design fire model means for structural design and how it differs from a safe design fire model for evacuation. Furthermore, the paper includes some experiences from the application of the design guide in practise...

  10. Evaluation of Appropriate Reference Genes for Reverse Transcription-Quantitative PCR Studies in Different Tissues of a Desert Poplar via Comparision of Different Algorithms

    Directory of Open Access Journals (Sweden)

    Hou-Ling Wang

    2015-08-01

    Full Text Available Despite the unshakable status of reverse transcription-quantitative PCR in gene expression analysis, it has certain disadvantages, including that the results are highly dependent on the reference genes selected for data normalization. Since inappropriate endogenous control genes will lead to inaccurate target gene expression profiles, the validation of suitable internal reference genes is essential. Given the increasing interest in functional genes and genomics of Populus euphratica, a desert poplar showing extraordinary adaptation to salt stress, we evaluated the expression stability of ten candidate reference genes in P. euphratica roots, stems, and leaves under salt stress conditions. We used five algorithms, namely, ΔCt, NormFinder, geNorm, GrayNorm, and a rank aggregation method (RankAggreg to identify suitable normalizers. To support the suitability of the identified reference genes and to compare the relative merits of these different algorithms, we analyzed and compared the relative expression levels of nine P. euphratica functional genes in different tissues. Our results indicate that a combination of multiple reference genes recommended by GrayNorm algorithm (e.g., a combination of Actin, EF1α, GAPDH, RP, UBQ in root should be used instead of a single reference gene. These results are valuable for research of gene identification in different P. euphratica tissues.

  11. Fast, Sequence Adaptive Parcellation of Brain MR Using Parametric Models

    DEFF Research Database (Denmark)

    Puonti, Oula; Iglesias, Juan Eugenio; Van Leemput, Koen

    2013-01-01

    In this paper we propose a method for whole brain parcellation using the type of generative parametric models typically used in tissue classification. Compared to the non-parametric, multi-atlas segmentation techniques that have become popular in recent years, our method obtains state-of-the-art ...

  12. Motivations of parametric studies

    International Nuclear Information System (INIS)

    Birac, C.

    1988-01-01

    The paper concerns the motivations of parametric studies in connection with the Programme for the Inspection of Steel Components PISC II. The objective of the PISC II exercise is to evaluate the effectiveness of current and advanced NDT techniques for inspection of reactor pressure vessel components. The parametric studies were initiated to determine the influence of some parameters on defect detection and dimensioning, and to increase the technical bases of the Round Robin Tests. A description is given of the content of the parametric studies including:- the effect of the defects' characteristics, the effect of equipment characteristics, the effect of cladding, and possible use of electromagnetic techniques. (U.K.)

  13. In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [11C]DASB in the Canine Brain.

    Directory of Open Access Journals (Sweden)

    Nick Van Laeken

    Full Text Available This first-in-dog study evaluates the use of the PET-radioligand [11C]DASB to image the density and availability of the serotonin transporter (SERT in the canine brain. Imaging the serotonergic system could improve diagnosis and therapy of multiple canine behavioural disorders. Furthermore, as many similarities are reported between several human neuropsychiatric conditions and naturally occurring canine behavioural disorders, making this tracer available for use in dogs also provide researchers an interesting non-primate animal model to investigate human disorders. Five adult beagles underwent a 90 minutes dynamic PET scan and arterial whole blood was sampled throughout the scan. For each ROI, the distribution volume (VT, obtained via the one- and two- tissue compartment model (1-TC, 2-TC and the Logan Plot, was calculated and the goodness-of-fit was evaluated by the Akaike Information Criterion (AIC. For the preferred compartmental model BPND values were estimated and compared with those derived by four reference tissue models: 4-parameter RTM, SRTM2, MRTM2 and the Logan reference tissue model. The 2-TC model indicated in 61% of the ROIs a better fit compared to the 1-TC model. The Logan plot produced almost identical VT values and can be used as an alternative. Compared with the 2-TC model, all investigated reference tissue models showed high correlations but small underestimations of the BPND-parameter. The highest correlation was achieved with the Logan reference tissue model (Y = 0.9266 x + 0.0257; R2 = 0.9722. Therefore, this model can be put forward as a non-invasive standard model for future PET-experiments with [11C]DASB in dogs.

  14. Selection of reference genes is critical for miRNA expression analysis in human cardiac tissue. A focus on atrial fibrillation.

    Science.gov (United States)

    Masè, Michela; Grasso, Margherita; Avogaro, Laura; D'Amato, Elvira; Tessarolo, Francesco; Graffigna, Angelo; Denti, Michela Alessandra; Ravelli, Flavia

    2017-01-24

    MicroRNAs (miRNAs) are emerging as key regulators of complex biological processes in several cardiovascular diseases, including atrial fibrillation (AF). Reverse transcription-quantitative polymerase chain reaction is a powerful technique to quantitatively assess miRNA expression profile, but reliable results depend on proper data normalization by suitable reference genes. Despite the increasing number of studies assessing miRNAs in cardiac disease, no consensus on the best reference genes has been reached. This work aims to assess reference genes stability in human cardiac tissue with a focus on AF investigation. We evaluated the stability of five reference genes (U6, SNORD48, SNORD44, miR-16, and 5S) in atrial tissue samples from eighteen cardiac-surgery patients in sinus rhythm and AF. Stability was quantified by combining BestKeeper, delta-C q , GeNorm, and NormFinder statistical tools. All methods assessed SNORD48 as the best and U6 as the worst reference gene. Applications of different normalization strategies significantly impacted miRNA expression profiles in the study population. Our results point out the necessity of a consensus on data normalization in AF studies to avoid the emergence of divergent biological conclusions.

  15. Selection of suitable reference genes for normalization of genes of interest in canine soft tissue sarcomas using quantitative real-time polymerase chain reaction.

    Science.gov (United States)

    Zornhagen, K W; Kristensen, A T; Hansen, A E; Oxboel, J; Kjaer, A

    2015-12-01

    Quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) is a sensitive technique for quantifying gene expression. Stably expressed reference genes are necessary for normalization of RT-qPCR data. Only a few articles have been published on reference genes in canine tumours. The objective of this study was to demonstrate how to identify suitable reference genes for normalization of genes of interest in canine soft tissue sarcomas using RT-qPCR. Primer pairs for 17 potential reference genes were designed and tested in archival tumour biopsies from six dogs. The geNorm algorithm was used to analyse the most suitable reference genes. Eight potential reference genes were excluded from this final analysis because of their dissociation curves. β-Glucuronidase (GUSB) and proteasome subunit, beta type, 6 (PSMB6) were most stably expressed with an M value of 0.154 and a CV of 0.053 describing their average stability. We suggest that choice of reference genes should be based on specific testing in every new experimental set-up. © 2014 John Wiley & Sons Ltd.

  16. Quantitative analysis and comparison study of [18F]AlF-NOTA-PRGD2, [18F]FPPRGD2 and [68Ga]Ga-NOTA-PRGD2 using a reference tissue model.

    Directory of Open Access Journals (Sweden)

    Ning Guo

    Full Text Available With favorable pharmacokinetics and binding affinity for α(vβ(3 integrin, (18F-labeled dimeric cyclic RGD peptide ([(18F]FPPRGD2 has been intensively used as a PET imaging probe for lesion detection and therapy response monitoring. A recently introduced kit formulation method, which uses an (18F-fluoride-aluminum complex labeled RGD tracer ([(18F]AlF-NOTA-PRGD2, provides a strategy for simplifying the labeling procedure to facilitate clinical translation. Meanwhile, an easy-to-prepare (68Ga-labeled NOTA-PRGD2 has also been reported to have promising properties for imaging integrin α(vβ(3. The purpose of this study is to quantitatively compare the pharmacokinetic parameters of [(18F]FPPRGD2, [(18F]AlF-NOTA-PRGD2, and [(68Ga]Ga-NOTA-PRGD2. U87MG tumor-bearing mice underwent 60-min dynamic PET scans following the injection of three tracers. Kinetic parameters were calculated using Logan graphical analysis with reference tissue. Parametric maps were generated using voxel-level modeling. All three compounds showed high binding potential (Bp(ND = k(3/k(4 in tumor voxels. [(18F]AlF-NOTA-PRGD2 showed comparable Bp(ND value (3.75±0.65 with those of [(18F]FPPRGD2 (3.39±0.84 and [(68Ga]Ga-NOTA-PRGD2 (3.09±0.21 (p>0.05. Little difference was found in volume of distribution (V(T among these three RGD tracers in tumor, liver and muscle. Parametric maps showed similar kinetic parameters for all three tracers. We also demonstrated that the impact of non-specific binding could be eliminated in the kinetic analysis. Consequently, kinetic parameter estimation showed more comparable results among groups than static image analysis. In conclusion, [(18F]AlF-NOTA-PRGD2 and [(68Ga]Ga-NOTA-PRGD2 have comparable pharmacokinetics and quantitative parameters compared to those of [(18F]FPPRGD2. Despite the apparent difference in tumor uptake (%ID/g determined from static images and clearance pattern, the actual specific binding component extrapolated from kinetic

  17. Reference values for the Chinese population of skin autofluorescence as a marker of advanced glycation end products accumulated in tissue

    NARCIS (Netherlands)

    Yue, X.; Hu, H.; Koetsier, M.; Graaff, R.; Han, C.

    Aim Advanced glycation end products play an important role in the pathophysiology of several chronic and age-related diseases, especially diabetes mellitus. Skin autofluorescence is a non-invasive method for assessing levels of tissue advanced glycation end products. This study aims to establish the

  18. PARAMETRIC DRAWINGS VS. AUTOLISP

    Directory of Open Access Journals (Sweden)

    PRUNĂ Liviu

    2015-06-01

    Full Text Available In this paper the authors make a critical analysis of the advantages offered by the parametric drawing use by comparison with the AutoLISP computer programs used when it comes about the parametric design. Studying and analysing these two work models the authors have got to some ideas and conclusions which should be considered in the moment in that someone must to decide if it is the case to elaborate a software, using the AutoLISP language, or to establish the base rules that must be followed by the drawing, in the idea to construct outlines or blocks which can be used in the projection process.

  19. PARAMETRIC DRAWINGS VS. AUTOLISP

    OpenAIRE

    PRUNĂ Liviu; SLONOVSCHI Andrei

    2015-01-01

    In this paper the authors make a critical analysis of the advantages offered by the parametric drawing use by comparison with the AutoLISP computer programs used when it comes about the parametric design. Studying and analysing these two work models the authors have got to some ideas and conclusions which should be considered in the moment in that someone must to decide if it is the case to elaborate a software, using the AutoLISP language, or to establish the base rules that must be followed...

  20. Selection and validation of reference genes for quantitative gene expression analyses in various tissues and seeds at different developmental stages in Bixa orellana L.

    Science.gov (United States)

    Moreira, Viviane S; Soares, Virgínia L F; Silva, Raner J S; Sousa, Aurizangela O; Otoni, Wagner C; Costa, Marcio G C

    2018-05-01

    Bixa orellana L., popularly known as annatto, produces several secondary metabolites of pharmaceutical and industrial interest, including bixin, whose molecular basis of biosynthesis remain to be determined. Gene expression analysis by quantitative real-time PCR (qPCR) is an important tool to advance such knowledge. However, correct interpretation of qPCR data requires the use of suitable reference genes in order to reduce experimental variations. In the present study, we have selected four different candidates for reference genes in B. orellana , coding for 40S ribosomal protein S9 (RPS9), histone H4 (H4), 60S ribosomal protein L38 (RPL38) and 18S ribosomal RNA (18SrRNA). Their expression stabilities in different tissues (e.g. flower buds, flowers, leaves and seeds at different developmental stages) were analyzed using five statistical tools (NormFinder, geNorm, BestKeeper, ΔCt method and RefFinder). The results indicated that RPL38 is the most stable gene in different tissues and stages of seed development and 18SrRNA is the most unstable among the analyzed genes. In order to validate the candidate reference genes, we have analyzed the relative expression of a target gene coding for carotenoid cleavage dioxygenase 1 (CCD1) using the stable RPL38 and the least stable gene, 18SrRNA , for normalization of the qPCR data. The results demonstrated significant differences in the interpretation of the CCD1 gene expression data, depending on the reference gene used, reinforcing the importance of the correct selection of reference genes for normalization.

  1. Identification of reference genes for RT-qPCR in ovine mammary tissue during late pregnancy and lactation and in response to maternal nutritional programming.

    Science.gov (United States)

    Paten, A M; Pain, S J; Peterson, S W; Blair, H T; Kenyon, P R; Dearden, P K; Duncan, E J

    2014-08-01

    The mammary gland is a complex tissue consisting of multiple cell types which, over the lifetime of an animal, go through repeated cycles of development associated with pregnancy, lactation and involution. The mammary gland is also known to be sensitive to maternal programming by environmental stimuli such as nutrition. The molecular basis of these adaptations is of significant interest, but requires robust methods to measure gene expression. Reverse-transcription quantitative PCR (RT-qPCR) is commonly used to measure gene expression, and is currently the method of choice for validating genome-wide expression studies. RT-qPCR requires the selection of reference genes that are stably expressed over physiological states and treatments. In this study we identify suitable reference genes to normalize RT-qPCR data for the ovine mammary gland in two physiological states; late pregnancy and lactation. Biopsies were collected from offspring of ewes that had been subjected to different nutritional paradigms during pregnancy to examine effects of maternal programming on the mammary gland of the offspring. We evaluated eight candidate reference genes and found that two reference genes (PRPF3 and CUL1) are required for normalising RT-qPCR data from pooled RNA samples, but five reference genes are required for analyzing gene expression in individual animals (SENP2, EIF6, MRPL39, ATP1A1, CUL1). Using these stable reference genes, we showed that TET1, a key regulator of DNA methylation, is responsive to maternal programming and physiological state. The identification of these novel reference genes will be of utility to future studies of gene expression in the ovine mammary gland. Copyright © 2014 the American Physiological Society.

  2. Controlling Parametric Resonance

    DEFF Research Database (Denmark)

    Galeazzi, Roberto; Pettersen, Kristin Ytterstad

    2012-01-01

    the authors review the conditions for the onset of parametric resonance, and propose a nonlinear control strategy in order to both induce the resonant oscillations and to stabilize the unstable motion. Lagrange’s theory is used to derive the dynamics of the system and input–output feedback linearization...

  3. Classification rates: non‐parametric verses parametric models using ...

    African Journals Online (AJOL)

    This research sought to establish if non parametric modeling achieves a higher correct classification ratio than a parametric model. The local likelihood technique was used to model fit the data sets. The same sets of data were modeled using parametric logit and the abilities of the two models to correctly predict the binary ...

  4. Assessment of stability of trace elements in two natural matrix environmental standard reference materials. NIST-SRM 1547 Peach leaves and NIST-SRM 1566a Oyster Tissue

    International Nuclear Information System (INIS)

    Mackey, E.A.; Spatz, R.O.

    2009-01-01

    The NIST program for environmental Standard Reference Materials (SRM) includes materials covering a range of matrices, mass fraction values and analytes. For many SRMs, mass fraction data are accumulated, incidentally, over time, as these are used routinely for quality assurance purposes. Although these are not formal stability studies, data generated may be useful in assessing stability. To evaluate the potential for assessing material stability from incidental use of SRMs, results of neutron activation analysis performed from 1992 through 2008 were compiled for SRM 1547 Peach Leaves and SRM 1566a Oyster Tissue. Results indicate that incidental use of SRMs yields useful information on SRM stability. (author)

  5. The radiographic and MRI features of gout referred as suspected soft tissue sarcoma: a review of the literature and findings from 27 cases

    Energy Technology Data Exchange (ETDEWEB)

    Upadhyay, Neil [Imperial College Healthcare NHS Trust, Imaging Department, London (United Kingdom); Saifuddin, Asif [The Royal National Orthopaedic Hospital NHS Trust, Department of Radiology, Stanmore, Middlesex (United Kingdom)

    2014-09-24

    Gout has been termed the ''great mimicker'', for its ability to resemble other pathological conditions. Whilst the typical imaging features of gout are well described, there is a relative paucity of literature describing more challenging cases of gout, where a malignant tumour has been considered in the differential diagnosis. The aim of this article is to provide an overview of the radiographic and MRI features of 27 cases of gout that were initially referred to our centre as suspected soft tissue sarcoma, alongside a review of the literature. (orig.)

  6. The radiographic and MRI features of gout referred as suspected soft tissue sarcoma: a review of the literature and findings from 27 cases

    International Nuclear Information System (INIS)

    Upadhyay, Neil; Saifuddin, Asif

    2015-01-01

    Gout has been termed the ''great mimicker'', for its ability to resemble other pathological conditions. Whilst the typical imaging features of gout are well described, there is a relative paucity of literature describing more challenging cases of gout, where a malignant tumour has been considered in the differential diagnosis. The aim of this article is to provide an overview of the radiographic and MRI features of 27 cases of gout that were initially referred to our centre as suspected soft tissue sarcoma, alongside a review of the literature. (orig.)

  7. Annotation Of Novel And Conserved MicroRNA Genes In The Build 10 Sus scrofa Reference Genome And Determination Of Their Expression Levels In Ten Different Tissues

    DEFF Research Database (Denmark)

    Thomsen, Bo; Nielsen, Mathilde; Hedegaard, Jakob

    The DNA template used in the pig genome sequencing project was provided by a Duroc pig named TJ Tabasco. In an effort to annotate microRNA (miRNA) genes in the reference genome we have conducted deep sequencing to determine the miRNA transcriptomes in ten different tissues isolated from Pinky......, a genetically identical clone of TJ Tabasco. The purpose was to generate miRNA sequences that are highly homologous to the reference genome sequence, which along with computational prediction will improve confidence in the genomic annotation of miRNA genes. Based on homology searches of the sequence data...... against miRBase, we identified more than 600 conserved known miRNA/miRNA*, which is a significant increase relative to the 211 porcine miRNA/miRNA* deposited in the current version of miRBase. Furthermore, the genome-wide transcript profiles provided important information on the relative abundance...

  8. Validation of the reference tissue model for estimation of dopaminergic D{sub 2}-like receptor binding with [{sup 18}F](N-methyl)benperidol in humans

    Energy Technology Data Exchange (ETDEWEB)

    Antenor-Dorsey, Jo Ann V. [Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO (United States); Markham, Joanne; Moerlein, Stephen M. [Department of Radiology, Washington University School of Medicine, St. Louis, MO (United States); Videen, Tom O. [Department of Radiology, Washington University School of Medicine, St. Louis, MO (United States); Department of Neurology, Washington University School of Medicine, St. Louis, MO (United States); Perlmutter, Joel S. [Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO (United States); Department of Radiology, Washington University School of Medicine, St. Louis, MO (United States); Department of Neurology, Washington University School of Medicine, St. Louis, MO (United States); Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO (United States)], E-mail: joel@npg.wustl.edu

    2008-04-15

    Positron emission tomography measurements of dopaminergic D{sub 2}-like receptors may provide important insights into disorders such as Parkinson's disease, schizophrenia, dystonia and Tourette's syndrome. The positron emission tomography (PET) radioligand [{sup 18}F](N-methyl)benperidol ([{sup 18}F]NMB) has high affinity and selectivity for D{sub 2}-like receptors and is not displaced by endogenous dopamine. The goal of this study is to evaluate the use of a graphical method utilizing a reference tissue region for [{sup 18}F]-NMB PET analysis by comparisons to an explicit three-compartment tracer kinetic model and graphical method that use arterial blood measurements. We estimated binding potential (BP) in the caudate and putamen using all three methods in 16 humans and found that the three-compartment tracer kinetic method provided the highest BP estimates while the graphical method using a reference region yielded the lowest estimates (P<.0001 by repeated-measures ANOVA). However, the three methods yielded highly correlated BP estimates for the two regions of interest. We conclude that the graphical method using a reference region still provides a useful estimate of BP comparable to methods using arterial blood sampling, especially since the reference region method is less invasive and computationally more straightforward, thereby simplifying these measurements.

  9. Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans

    International Nuclear Information System (INIS)

    Antenor-Dorsey, Jo Ann V.; Markham, Joanne; Moerlein, Stephen M.; Videen, Tom O.; Perlmutter, Joel S.

    2008-01-01

    Positron emission tomography measurements of dopaminergic D 2 -like receptors may provide important insights into disorders such as Parkinson's disease, schizophrenia, dystonia and Tourette's syndrome. The positron emission tomography (PET) radioligand [ 18 F](N-methyl)benperidol ([ 18 F]NMB) has high affinity and selectivity for D 2 -like receptors and is not displaced by endogenous dopamine. The goal of this study is to evaluate the use of a graphical method utilizing a reference tissue region for [ 18 F]-NMB PET analysis by comparisons to an explicit three-compartment tracer kinetic model and graphical method that use arterial blood measurements. We estimated binding potential (BP) in the caudate and putamen using all three methods in 16 humans and found that the three-compartment tracer kinetic method provided the highest BP estimates while the graphical method using a reference region yielded the lowest estimates (P<.0001 by repeated-measures ANOVA). However, the three methods yielded highly correlated BP estimates for the two regions of interest. We conclude that the graphical method using a reference region still provides a useful estimate of BP comparable to methods using arterial blood sampling, especially since the reference region method is less invasive and computationally more straightforward, thereby simplifying these measurements

  10. Selection of reference genes for quantitative real-time PCR expression studies of microdissected reproductive tissues in apomictic and sexual Boechera

    Directory of Open Access Journals (Sweden)

    Amiteye Samuel

    2011-08-01

    Full Text Available Abstract Background Apomixis, a natural form of asexual seed production in plants, is considered to have great biotechnological potential for agriculture. It has been hypothesised that de-regulation of the sexual developmental pathway could trigger apomictic reproduction. The genus Boechera represents an interesting model system for understanding apomixis, having both sexual and apomictic genotypes at the diploid level. Quantitative qRT-PCR is the most extensively used method for validating genome-wide gene expression analyses, but in order to obtain reliable results, suitable reference genes are necessary. In this work we have evaluated six potential reference genes isolated from a 454 (FLX derived cDNA library of Boechera. RNA from live microdissected ovules and anthers at different developmental stages, as well as vegetative tissues of apomictic and sexual Boechera, were used to validate the candidates. Results Based on homologies with Arabidopsis, six genes were selected from a 454 cDNA library of Boechera: RPS18 (Ribosomal sub protein 18, Efalpha1 (Elongation factor 1 alpha, ACT 2 (Actin2, UBQ (polyubiquitin, PEX4 (Peroxisomal ubiquitin conjugating enzyme and At1g09770.1 (Arabidopsis thaliana cell division cycle 5. Total RNA was extracted from 17 different tissues, qRT-PCRs were performed, and raw Ct values were analyzed for primer efficiencies and gene ratios. The geNorm and normFinder applications were used for selecting the most stable genes among all tissues and specific tissue groups (ovule, anthers and vegetative tissues in both apomictic and sexual plants separately. Our results show that BoechRPS18, BoechEfα1, BoechACT2 and BoechUBQ were the most stable genes. Based on geNorm, the combinations of BoechRPS18 and BoechEfα1 or BoechUBQ and BoechEfα1 were the most stable in the apomictic plant, while BoechRPS18 and BoechACT2 or BoechUBQ and BoechACT2 performed best in the sexual plant. When subgroups of tissue samples were analyzed

  11. Towards Stabilizing Parametric Active Contours

    DEFF Research Database (Denmark)

    Liu, Jinchao; Fan, Zhun; Olsen, Søren Ingvor

    2014-01-01

    Numerical instability often occurs in evolving of parametric active contours. This is mainly due to the undesired change of parametrization during evolution. In this paper, we propose a new tangential diffusion term to compensate this undesired change. As a result, the parametrization will converge...

  12. Food allergens and mucosal immune systems with special reference to recognition of food allergens by gut-associated lymphoid tissue

    Directory of Open Access Journals (Sweden)

    Shuichi Kaminogawa

    1999-01-01

    Full Text Available Food allergy, triggered by an aberrant immune response elicited by orally ingested food allergens, is generated through a complicated mechanism because the allergen interacts with the mucosal immune system (the gut- associated lymphoid tissue, GALT and the resulting immune response affects the generation of allergy. This review will describe the process by which antigens or allergens are recognized by the GALT and the characteristic immune responses induced thereafter. Orally administered antigens induce distinct immune responses in the Peyer's patches, lamina propria and the intestinal epithelium. In addition to these local immune responses in the gut, ingested antigens are known to affect systemic immunity. These may induce a suppressed state of systemic immune responsiveness, which is called oral tolerance, or in some cases they may elicit a systemic IgE antibody response which may lead to allergic reactions. Information on the regions on food allergens recognized by T cells and IgE antibodies is important in understanding the fates of food allergens after being recognized by the GALT. The structure of T and B cell epitopes on food allergens and the possibility of modulation of allergic reactions by amino-acid substituted analogs of allergen- derived peptides will also be discussed.

  13. Effects of nitrogen infiltration into plant tissue on the metabolism of carbon, with special reference to Themeda triandra Forssk

    Energy Technology Data Exchange (ETDEWEB)

    Amory, A M

    1983-01-01

    The infiltration of nitrate and ammonia into Themeda triandra and Zea mays leaf tissue influenced the carbon dioxide gas exchange characteristics: 1) the carbon dioxide compensation point increased, 2) the net photosynthetic rate was increased by the nitrate ion and decreased by the ammonium ion, and 3) dark respiration was unaffected. /sup 14/CO/sub 2/ assimilation and the partitioning of /sup 14/C by Themeda triandra leaves were influenced by the infiltration of both forms of nitrogen; the amino acid fraction changed in both composition and concentration. Nitrogen infiltration increased the activities of the following enzymes: aspartate amino-transferase, PEP carboxylase and RuBP carboxylase. Methionine sulphoximine (inhibitor of glutamate synthetase) increased the carbon dioxide compensation point and formate pool size. Infiltration of nitrate and ammonia enhanced the /sup 14/C uptake from labelled glycolate, glyoxylate and formate into the water soluble fraction of Themeda triandra leaves. The activities of RuBP carboxylase and RuBP oxygenase (to a greater extent) were increased by the addition of nitrate and ammonia in vitro.

  14. MEMS digital parametric loudspeaker

    KAUST Repository

    Carreno, Armando Arpys Arevalo

    2016-03-23

    This paper reports on the design and fabrication of MEMS actuator arrays suitable for Digital Sound reconstruction and Parametric Directional Loudspeakers. Two distinct versions of the device were fabricated: one using the electrostatic principle actuation and the other one, the piezoelectric principle. Both versions used similar membrane dimensions, with a diameter of 500 μm. These devices are the smallest Micro-Machined Ultrasound Transducer (MUT) arrays that can be operated for both modes: Digital Sound Reconstruction and Parametric Loudspeaker. The chips consist of an array with 256 transducers, in a footprint of 12 mm by 12 mm. The total single chip size is: 2.3 cm by 2.3 cm, including the contact pads. © 2016 IEEE.

  15. Parametric Explosion Spectral Model

    Energy Technology Data Exchange (ETDEWEB)

    Ford, S R; Walter, W R

    2012-01-19

    Small underground nuclear explosions need to be confidently detected, identified, and characterized in regions of the world where they have never before occurred. We develop a parametric model of the nuclear explosion seismic source spectrum derived from regional phases that is compatible with earthquake-based geometrical spreading and attenuation. Earthquake spectra are fit with a generalized version of the Brune spectrum, which is a three-parameter model that describes the long-period level, corner-frequency, and spectral slope at high-frequencies. Explosion spectra can be fit with similar spectral models whose parameters are then correlated with near-source geology and containment conditions. We observe a correlation of high gas-porosity (low-strength) with increased spectral slope. The relationship between the parametric equations and the geologic and containment conditions will assist in our physical understanding of the nuclear explosion source.

  16. MEMS digital parametric loudspeaker

    KAUST Repository

    Carreno, Armando Arpys Arevalo; Castro, David; Conchouso Gonzalez, David; Kosel, Jü rgen; Foulds, Ian G.

    2016-01-01

    This paper reports on the design and fabrication of MEMS actuator arrays suitable for Digital Sound reconstruction and Parametric Directional Loudspeakers. Two distinct versions of the device were fabricated: one using the electrostatic principle actuation and the other one, the piezoelectric principle. Both versions used similar membrane dimensions, with a diameter of 500 μm. These devices are the smallest Micro-Machined Ultrasound Transducer (MUT) arrays that can be operated for both modes: Digital Sound Reconstruction and Parametric Loudspeaker. The chips consist of an array with 256 transducers, in a footprint of 12 mm by 12 mm. The total single chip size is: 2.3 cm by 2.3 cm, including the contact pads. © 2016 IEEE.

  17. Macromechanical Parametric Amplification

    DEFF Research Database (Denmark)

    Neumeyer, Stefan

    between the two peaks can be altered. The first experimental bistable amplified steady-state responses are also reported. The derived analytical models and experimental setups can readily be extended to investigate other factors. Some of the results are also applicable to the more general field of systems...... for energy harvesting. Using analytical, numerical, and experimental methods, the thesis focuses on superthreshold pumping (above the systems parametric instability threshold), nonlinear effects, frequency response backbones, and frequency detuning effects for parametric amplifiers. Part one of the thesis...... covers superthreshold pumping and nonlinear effects. Superthresh-old pumping produces some useful characteristics. For instance, strong superthreshold pumping yields a high gain even though nonlinear effects tend to reduce it. In addition, a narrower excitation phase range is realized for which...

  18. Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes.

    Science.gov (United States)

    Tweedy, Joshua G; Escriva, Eric; Topf, Maya; Gompels, Ursula A

    2017-12-31

    Tissue-culture adaptation of viruses can modulate infection. Laboratory passage and bacterial artificial chromosome (BAC)mid cloning of human cytomegalovirus, HCMV, resulted in genomic deletions and rearrangements altering genes encoding the virus entry complex, which affected cellular tropism, virulence, and vaccine development. Here, we analyse these effects on the reference genome for related betaherpesviruses, Roseolovirus, human herpesvirus 6A (HHV-6A) strain U1102. This virus is also naturally "cloned" by germline subtelomeric chromosomal-integration in approximately 1% of human populations, and accurate references are key to understanding pathological relationships between exogenous and endogenous virus. Using whole genome next-generation deep-sequencing Illumina-based methods, we compared the original isolate to tissue-culture passaged and the BACmid-cloned virus. This re-defined the reference genome showing 32 corrections and 5 polymorphisms. Furthermore, minor variant analyses of passaged and BACmid virus identified emerging populations of a further 32 single nucleotide polymorphisms (SNPs) in 10 loci, half non-synonymous indicating cell-culture selection. Analyses of the BAC-virus genome showed deletion of the BAC cassette via loxP recombination removing green fluorescent protein (GFP)-based selection. As shown for HCMV culture effects, select HHV-6A SNPs mapped to genes encoding mediators of virus cellular entry, including virus envelope glycoprotein genes gB and the gH/gL complex. Comparative models suggest stabilisation of the post-fusion conformation. These SNPs are essential to consider in vaccine-design, antimicrobial-resistance, and pathogenesis.

  19. Parametric Resonance in Dynamical Systems

    CERN Document Server

    Nijmeijer, Henk

    2012-01-01

    Parametric Resonance in Dynamical Systems discusses the phenomenon of parametric resonance and its occurrence in mechanical systems,vehicles, motorcycles, aircraft and marine craft, and micro-electro-mechanical systems. The contributors provide an introduction to the root causes of this phenomenon and its mathematical equivalent, the Mathieu-Hill equation. Also included is a discussion of how parametric resonance occurs on ships and offshore systems and its frequency in mechanical and electrical systems. This book also: Presents the theory and principles behind parametric resonance Provides a unique collection of the different fields where parametric resonance appears including ships and offshore structures, automotive vehicles and mechanical systems Discusses ways to combat, cope with and prevent parametric resonance including passive design measures and active control methods Parametric Resonance in Dynamical Systems is ideal for researchers and mechanical engineers working in application fields such as MEM...

  20. Tremor Detection Using Parametric and Non-Parametric Spectral Estimation Methods: A Comparison with Clinical Assessment

    Science.gov (United States)

    Martinez Manzanera, Octavio; Elting, Jan Willem; van der Hoeven, Johannes H.; Maurits, Natasha M.

    2016-01-01

    In the clinic, tremor is diagnosed during a time-limited process in which patients are observed and the characteristics of tremor are visually assessed. For some tremor disorders, a more detailed analysis of these characteristics is needed. Accelerometry and electromyography can be used to obtain a better insight into tremor. Typically, routine clinical assessment of accelerometry and electromyography data involves visual inspection by clinicians and occasionally computational analysis to obtain objective characteristics of tremor. However, for some tremor disorders these characteristics may be different during daily activity. This variability in presentation between the clinic and daily life makes a differential diagnosis more difficult. A long-term recording of tremor by accelerometry and/or electromyography in the home environment could help to give a better insight into the tremor disorder. However, an evaluation of such recordings using routine clinical standards would take too much time. We evaluated a range of techniques that automatically detect tremor segments in accelerometer data, as accelerometer data is more easily obtained in the home environment than electromyography data. Time can be saved if clinicians only have to evaluate the tremor characteristics of segments that have been automatically detected in longer daily activity recordings. We tested four non-parametric methods and five parametric methods on clinical accelerometer data from 14 patients with different tremor disorders. The consensus between two clinicians regarding the presence or absence of tremor on 3943 segments of accelerometer data was employed as reference. The nine methods were tested against this reference to identify their optimal parameters. Non-parametric methods generally performed better than parametric methods on our dataset when optimal parameters were used. However, one parametric method, employing the high frequency content of the tremor bandwidth under consideration

  1. Parametric Architecture in the Urban Space

    Science.gov (United States)

    Januszkiewicz, Krystyna; Kowalski, Karol G.

    2017-10-01

    The paper deals with the parametric architecture which is trying to introduce a new spatial language in the context for urban tissue that correspond to the artistic consciousness and the attitude of information and digital technologies era. The first part of the paper defines the main features of parametric architecture (such as: folding, continuity and curvilinearity) which are are characteristic of the new style of named the “parametricism”. This architecture is a strong emphasis on geometry, materiality, feasibility and sustainability, what emerges is an explicit agenda promoting material ornamentation, spatial spectacle and formal theatricality. The second part presents result of case study, especially parametric public use buildings, within the tissue of city. The analyzed objects are: The Sage Gateshead (1998-2004) in Gateshead, Kunsthaus in Graz (2000-2003), the Weltstadthaus (2003-2005) in Cologne, The Golden Terraces in Warsaw (2000-2007), the Metropol Parasol in Seville (2005-2011) the King Cross Station (2005-2012) in London, the headquarters of the Pathé Foundation (2006-2014) in Paris. Each of the enumerated examples shows a diverse approach to designing in the urban space, which reflect the age of digital technologies and the information society. In conclusion emphasizes, that new concept of the spatialization of architecture is the equivalent of the democratization of the political system, the liberalization of the economy, among other examples.

  2. Brownian parametric oscillators

    Science.gov (United States)

    Zerbe, Christine; Jung, Peter; Hänggi, Peter

    1994-05-01

    We discuss the stochastic dynamics of dissipative, white-noise-driven Floquet oscillators, characterized by a time-periodic stiffness. Thus far, little attention has been paid to these exactly solvable nonstationary systems, although they carry a rich potential for several experimental applications. Here, we calculate and discuss the mean values and variances, as well as the correlation functions and the Floquet spectrum. As one main result, we find for certain parameter values that the fluctuations of the position coordinate are suppressed as compared to the equilibrium value of a harmonic oscillator (parametric squeezing).

  3. Parametric Linear Dynamic Logic

    Directory of Open Access Journals (Sweden)

    Peter Faymonville

    2014-08-01

    Full Text Available We introduce Parametric Linear Dynamic Logic (PLDL, which extends Linear Dynamic Logic (LDL by temporal operators equipped with parameters that bound their scope. LDL was proposed as an extension of Linear Temporal Logic (LTL that is able to express all ω-regular specifications while still maintaining many of LTL's desirable properties like an intuitive syntax and a translation into non-deterministic Büchi automata of exponential size. But LDL lacks capabilities to express timing constraints. By adding parameterized operators to LDL, we obtain a logic that is able to express all ω-regular properties and that subsumes parameterized extensions of LTL like Parametric LTL and PROMPT-LTL. Our main technical contribution is a translation of PLDL formulas into non-deterministic Büchi word automata of exponential size via alternating automata. This yields a PSPACE model checking algorithm and a realizability algorithm with doubly-exponential running time. Furthermore, we give tight upper and lower bounds on optimal parameter values for both problems. These results show that PLDL model checking and realizability are not harder than LTL model checking and realizability.

  4. Nanoscale electromechanical parametric amplifier

    Science.gov (United States)

    Aleman, Benjamin Jose; Zettl, Alexander

    2016-09-20

    This disclosure provides systems, methods, and apparatus related to a parametric amplifier. In one aspect, a device includes an electron source electrode, a counter electrode, and a pumping electrode. The electron source electrode may include a conductive base and a flexible conductor. The flexible conductor may have a first end and a second end, with the second end of the flexible conductor being coupled to the conductive base. A cross-sectional dimension of the flexible conductor may be less than about 100 nanometers. The counter electrode may be disposed proximate the first end of the flexible conductor and spaced a first distance from the first end of the flexible conductor. The pumping electrode may be disposed proximate a length of the flexible conductor and spaced a second distance from the flexible conductor.

  5. Parametric Room Acoustic Workflows

    DEFF Research Database (Denmark)

    Parigi, Dario; Svidt, Kjeld; Molin, Erik

    2017-01-01

    The paper investigates and assesses different room acoustics software and the opportunities they offer to engage in parametric acoustics workflow and to influence architectural designs. The first step consists in the testing and benchmarking of different tools on the basis of accuracy, speed...... and interoperability with Grasshopper 3d. The focus will be placed to the benchmarking of three different acoustic analysis tools based on raytracing. To compare the accuracy and speed of the acoustic evaluation across different tools, a homogeneous set of acoustic parameters is chosen. The room acoustics parameters...... included in the set are reverberation time (EDT, RT30), clarity (C50), loudness (G), and definition (D50). Scenarios are discussed for determining at different design stages the most suitable acoustic tool. Those scenarios are characterized, by the use of less accurate but fast evaluation tools to be used...

  6. Parametric Human Movements

    DEFF Research Database (Denmark)

    Herzog, Dennis

    adapt the primitives to the actual appearance of the tracked motion, since the appearance of actions depends on the object locations. From the recognition perspective, it is necessary to recognize a performed action, but the understanding requires also the recovery of the action parameters, which can......The thesis aims at the learning of action primitives and their application on the perceptive side (tracking/recognition) and the generative side (synthesizing for robot control). A motivation is to use a unified primitive representation applicable on both sides. The thesis considers arm actions...... with an investigation of PHMM training methods and structures to utilize the PHMM as a unified representation of parametric primitives, which is adequate for recognition and for synthesis. This is evaluated on a large motion data set. Main contributions of the thesis are the development and evaluation of approaches...

  7. Molecular and parametric imaging with iron oxides

    International Nuclear Information System (INIS)

    Matuszewski, L.; Bremer, C.; Tombach, B.; Heindel, W.

    2007-01-01

    Superparamagnetic iron oxide (SPIO) contrast agents, clinically established for high resolution magnetic resonance imaging of reticuloendothelial system containing anatomical structures, can additionally be exploited for the non-invasive characterization and quantification of pathology down to the molecular level. In this context, SPIOs can be applied for non-invasive cell tracking, quantification of tissue perfusion and target specific imaging, as well as for the detection of gene expression. This article provides an overview of new applications for clinically approved iron oxides as well of new, modified SPIO contrast agents for parametric and molecular imaging. (orig.) [de

  8. Robust Parametric Control of Spacecraft Rendezvous

    Directory of Open Access Journals (Sweden)

    Dake Gu

    2014-01-01

    Full Text Available This paper proposes a method to design the robust parametric control for autonomous rendezvous of spacecrafts with the inertial information with uncertainty. We consider model uncertainty of traditional C-W equation to formulate the dynamic model of the relative motion. Based on eigenstructure assignment and model reference theory, a concise control law for spacecraft rendezvous is proposed which could be fixed through solving an optimization problem. The cost function considers the stabilization of the system and other performances. Simulation results illustrate the robustness and effectiveness of the proposed control.

  9. Parametric Mass Reliability Study

    Science.gov (United States)

    Holt, James P.

    2014-01-01

    The International Space Station (ISS) systems are designed based upon having redundant systems with replaceable orbital replacement units (ORUs). These ORUs are designed to be swapped out fairly quickly, but some are very large, and some are made up of many components. When an ORU fails, it is replaced on orbit with a spare; the failed unit is sometimes returned to Earth to be serviced and re-launched. Such a system is not feasible for a 500+ day long-duration mission beyond low Earth orbit. The components that make up these ORUs have mixed reliabilities. Components that make up the most mass-such as computer housings, pump casings, and the silicon board of PCBs-typically are the most reliable. Meanwhile components that tend to fail the earliest-such as seals or gaskets-typically have a small mass. To better understand the problem, my project is to create a parametric model that relates both the mass of ORUs to reliability, as well as the mass of ORU subcomponents to reliability.

  10. Planar Parametrization in Isogeometric Analysis

    DEFF Research Database (Denmark)

    Gravesen, Jens; Evgrafov, Anton; Nguyen, Dang-Manh

    2012-01-01

    Before isogeometric analysis can be applied to solving a partial differential equation posed over some physical domain, one needs to construct a valid parametrization of the geometry. The accuracy of the analysis is affected by the quality of the parametrization. The challenge of computing...... and maintaining a valid geometry parametrization is particularly relevant in applications of isogemetric analysis to shape optimization, where the geometry varies from one optimization iteration to another. We propose a general framework for handling the geometry parametrization in isogeometric analysis and shape...... are suitable for our framework. The non-linear methods we consider are based on solving a constrained optimization problem numerically, and are divided into two classes, geometry-oriented methods and analysis-oriented methods. Their performance is illustrated through a few numerical examples....

  11. Parametric FEM for geometric biomembranes

    Science.gov (United States)

    Bonito, Andrea; Nochetto, Ricardo H.; Sebastian Pauletti, M.

    2010-05-01

    We consider geometric biomembranes governed by an L2-gradient flow for bending energy subject to area and volume constraints (Helfrich model). We give a concise derivation of a novel vector formulation, based on shape differential calculus, and corresponding discretization via parametric FEM using quadratic isoparametric elements and a semi-implicit Euler method. We document the performance of the new parametric FEM with a number of simulations leading to dumbbell, red blood cell and toroidal equilibrium shapes while exhibiting large deformations.

  12. Fast and Sequence-Adaptive Whole-Brain Segmentation Using Parametric Bayesian Modeling

    DEFF Research Database (Denmark)

    Puonti, Oula; Iglesias, Juan Eugenio; Van Leemput, Koen

    2016-01-01

    the performance of a segmentation algorithm designed to meet these requirements, building upon generative parametric models previously used in tissue classification. The method is tested on four different datasets acquired with different scanners, field strengths and pulse sequences, demonstrating comparable...

  13. Parametric design using IGRIP

    International Nuclear Information System (INIS)

    Baker, C.

    1994-10-01

    The Department of Energy's (DOE) Hanford site near Richland, Washington is being cleaned up after 50 years of nuclear materials production. One of the most serious problems at the site is the waste stored in single-shell underground storage tanks. There are 149 of these tanks containing the spent fuel residue remaining after the fuel is dissolved in acid and the desired materials (primarily plutonium and uranium) are separated out. The tanks are upright cylinders 75 ft. in diameter with domed tops. They are made of reinforced concrete, have steel liners, and each tank is buried under 7--12 ft. of overburden. The tanks are up to 40-ft. high, and have capacities of 500,000, 750,000, or 1,000,000 gallons of waste. As many as one-third of these tanks are known or suspected to leak. The waste form contained in the tanks varies in consistency from liquid supernatant to peanut-butter-like gels and sludges to hard salt cake (perhaps as hard as low-grade concrete). The current waste retrieval plan is to insert a large long-reach manipulator through a hole cut in the top of the tank, and use a variety of end-effectors to mobilize the waste and remove it from the tank. PNL has, with the assistance of Deneb robotics employees, developed a means of using the IGRIP code to perform parametric design of mechanical systems. This method requires no modifications to the IGRIP code, and all design data are stored in the IGRIP workcell. The method is presented in the context of development of a passive articulated mechanism that is used to deliver down-arm services to a gantry robot. The method is completely general, however, and could be used to design a fully articulated manipulator. Briefly, the method involves using IGCALC expressions to control manipulator joint angles, and IGCALC variables to allow user control of link lengths and offsets. This paper presents the method in detail, with examples drawn from PNL's experience with the gantry robot service-providing mechanism

  14. Parametric study of prospective early commercial OCMHD power plants /PSPEC/

    Science.gov (United States)

    Marston, C. H.; Bender, D. J.; Hnat, J. G.; Dellinger, T. C.

    1980-06-01

    The paper presents a parametric study conducted to obtain the performance, economics, natural resource requirements, and environmental impact of moderate technology MHD/steam power plants that do not require development of direct-fired high-temperature air heaters. The study was divided into three base cases, each with a reference case and parametric variations. The case using recuperative air preheat in the range of 1000 F to 1300 F, combined with O2 enrichment to 42% by volume has been selected for conceptual design.

  15. STATCAT, Statistical Analysis of Parametric and Non-Parametric Data

    International Nuclear Information System (INIS)

    David, Hugh

    1990-01-01

    1 - Description of program or function: A suite of 26 programs designed to facilitate the appropriate statistical analysis and data handling of parametric and non-parametric data, using classical and modern univariate and multivariate methods. 2 - Method of solution: Data is read entry by entry, using a choice of input formats, and the resultant data bank is checked for out-of- range, rare, extreme or missing data. The completed STATCAT data bank can be treated by a variety of descriptive and inferential statistical methods, and modified, using other standard programs as required

  16. Ionospheric modification and parametric instabilities

    International Nuclear Information System (INIS)

    Fejer, J.A.

    1979-01-01

    Thresholds and linear growth rates for stimulated Brillouin and Raman scattering and for the parametric decay instability are derived by using arguments of energy transfer. For this purpose an expression for the ponderomotive force is derived. Conditions under which the partial pressure force due to differential dissipation exceeds the ponderomotive force are also discussed. Stimulated Brillouin and Raman scattering are weakly excited by existing incoherent backscatter radars. The parametric decay instability is strongly excited in ionospheric heating experiments. Saturation theories of the parametric decay instability are therefore described. After a brief discussion of the purely growing instability the effect of using several pumps is discussed as well as the effects of inhomogenicity. Turning to detailed theories of ionospheric heating, artificial spread F is discussed in terms of a purely growing instability where the nonlinearity is due to dissipation. Field-aligned short-scale striations are explained in terms of dissipation of the parametrically excited Langmuir waves (plasma oscillations): they might be further amplified by an explosive instability (except the magnetic equator). Broadband absorption is probably responsible for the 'overshoot' effect: the initially observed level of parametrically excited Langmuir waves is much higher than the steady state level

  17. Parametric Thinking in Urban Design

    DEFF Research Database (Denmark)

    Steinø, Nicolai

    2010-01-01

    The paper states that most applications of parametric mod- elling to architecture and urban design fall into one of two strands of either form for form’s sake, or the negotiation of environmental con- cerns, while approaches which allow scenarios to be easily tested and modified without the appli...... of the paper. The pros and cons of this simple approach is discussed, and the paper con- cludes, that while it does not represent a suitable solution in all cases, it fills a gap among the existing approaches to parametric urban de- sign.......The paper states that most applications of parametric mod- elling to architecture and urban design fall into one of two strands of either form for form’s sake, or the negotiation of environmental con- cerns, while approaches which allow scenarios to be easily tested and modified without...

  18. Entanglement in a parametric converter

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Su-Yong; Qamar, Shahid; Lee, Hai-Woong; Zubairy, M Suhail [Center for Quantum Physics, COMSATS Institute of Information Technology, Islamabad (Pakistan)], E-mail: shahid_qamar@pieas.edu.pk, E-mail: zubairy@physics.tamu.edu

    2008-07-28

    In this paper, we consider a parametric converter as a source of entangled radiation. We examine recently derived conditions (Hillery and Zubairy 2006 Phys. Rev. Lett. 96 050503, Duan et al 2000 Phys. Rev. Lett. 84 2722) for determining when the two output modes in a parametric converter are entangled. We show that for different initial field states, the two criteria give different conditions that ensure that the output states are entangled. We also present an input-output calculation for the entanglement of the output field.

  19. Variance in parametric images: direct estimation from parametric projections

    International Nuclear Information System (INIS)

    Maguire, R.P.; Leenders, K.L.; Spyrou, N.M.

    2000-01-01

    Recent work has shown that it is possible to apply linear kinetic models to dynamic projection data in PET in order to calculate parameter projections. These can subsequently be back-projected to form parametric images - maps of parameters of physiological interest. Critical to the application of these maps, to test for significant changes between normal and pathophysiology, is an assessment of the statistical uncertainty. In this context, parametric images also include simple integral images from, e.g., [O-15]-water used to calculate statistical parametric maps (SPMs). This paper revisits the concept of parameter projections and presents a more general formulation of the parameter projection derivation as well as a method to estimate parameter variance in projection space, showing which analysis methods (models) can be used. Using simulated pharmacokinetic image data we show that a method based on an analysis in projection space inherently calculates the mathematically rigorous pixel variance. This results in an estimation which is as accurate as either estimating variance in image space during model fitting, or estimation by comparison across sets of parametric images - as might be done between individuals in a group pharmacokinetic PET study. The method based on projections has, however, a higher computational efficiency, and is also shown to be more precise, as reflected in smooth variance distribution images when compared to the other methods. (author)

  20. PARAMETRIC MODEL OF LUMBAR VERTEBRA

    Directory of Open Access Journals (Sweden)

    CAPPETTI Nicola

    2010-11-01

    Full Text Available The present work proposes the realization of a parametric/variational CAD model of a normotype lumbar vertebra, which could be used for improving the effectiveness of actual imaging techniques in informational augmentation of the orthopaedic and traumatological diagnosis. In addition it could be used for ergonomic static and dynamical analysis of the lumbar region and vertebral column.

  1. Parametric programming of industrial robots

    Directory of Open Access Journals (Sweden)

    Szulczyński Paweł

    2015-06-01

    Full Text Available This article proposes the use of parametric design software, commonly used by architects, in order to obtain complex trajectory and program code for industrial robots. The paper describes the drawbacks of existing solutions and proposes a new script to obtain a correct program. The result of the algorithm was verified experimentally.

  2. Oxidation of glucose-U-/sup 14/C and synthesis of glycogen in different tissues of the garden snail, Cryptozona ligulata with reference to aestivation and starvation

    Energy Technology Data Exchange (ETDEWEB)

    Krupanidhi, S; Raghavaiah, K; Padmanabha Naidu, B; Ramamurthi, R [Sri Venkateswara Univ., Tirupati (India). Dept. of Zoology

    1978-03-01

    The percent decrease of glycogen content in all the tissues investigated is more in 20-days starved snails than the 4-months aestivated snails when compared to active snails. Recovery of administered glucose-U/sup 14/C in the respiratory CO/sub 2/ is 42.27 % in active snails, whereas it is 8.81 % and 26.09 % in aestivated and starved snails respectively. Maximum levels of incorporation labelled glucose were found at 18 hr in all the tissues and the rate of incorporation was greatly elevated in the tissues of aestivated and starved snails. The causes for the difference in the rates of incorporation and the utilization of glycogen in active, aestivated and starved snails are discussed.

  3. Towards a parametrization of multiparticle hadronic reactions

    International Nuclear Information System (INIS)

    Giffon, M.; Hama, Y.; Predazzi, E.

    1979-11-01

    An explicit parametrization of high energy exclusive production cross-sections is shown to give a reasonable account of inclusive data. This is a first step towards a phenomenological parametrization of multiparticle hadronic amplitudes

  4. Bianchi surfaces: integrability in an arbitrary parametrization

    International Nuclear Information System (INIS)

    Nieszporski, Maciej; Sym, Antoni

    2009-01-01

    We discuss integrability of normal field equations of arbitrarily parametrized Bianchi surfaces. A geometric definition of the Bianchi surfaces is presented as well as the Baecklund transformation for the normal field equations in an arbitrarily chosen surface parametrization.

  5. Infection studies with two highly pathogenic avian influenza strains (Vietnamese and Indonesian) in Pekin ducks (Anas platyrhynchos), with particular reference to clinical disease, tissue tropism and viral shedding.

    Science.gov (United States)

    Bingham, John; Green, Diane J; Lowther, Sue; Klippel, Jessica; Burggraaf, Simon; Anderson, Danielle E; Wibawa, Hendra; Hoa, Dong Manh; Long, Ngo Thanh; Vu, Pham Phong; Middleton, Deborah J; Daniels, Peter W

    2009-08-01

    Pekin ducks were infected by the mucosal route (oral, nasal, ocular) with one of two strains of Eurasian lineage H5N1 highly pathogenic avian influenza virus: A/Muscovy duck/Vietnam/453/2004 and A/duck/Indramayu/BBVW/109/2006 (from Indonesia). Ducks were killed humanely on days 1, 2, 3, 5 and 7 after challenge, or whenever morbidity was severe enough to justify euthanasia. Morbidity was recorded by observation of clinical signs and cloacal temperatures; the disease was characterized by histopathology; tissue tropism was studied by immunohistochemistry and virus titration on tissue samples; and viral shedding patterns were determined by virus isolation and titration of oral and cloacal swabs. The Vietnamese strain caused severe morbidity with fever and depression; the Indonesian strain caused only transient fever. Both viruses had a predilection for a similar range of tissue types, but the quantity of tissue antigen and tissue virus titres were considerably higher with the Vietnamese strain. The Vietnamese strain caused severe myocarditis and skeletal myositis; both strains caused non-suppurative encephalitis and a range of other inflammatory reactions of varying severity. The principal epithelial tissue infected was that of the air sacs, but antigen was not abundant. Epithelium of the turbinates, trachea and bronchi had only rare infection with virus. Virus was shed from both the oral and cloacal routes; it was first detected 24 h after challenge and persisted until day 5 after challenge. The higher prevalence of virus from swabs from ducks infected with the Vietnamese strain indicates that this strain may be more adapted to ducks than the Indonesia strain.

  6. Detection of Parametric Roll on Ships

    DEFF Research Database (Denmark)

    Galeazzi, Roberto; Blanke, Mogens; Poulsen, Niels Kjølstad

    2012-01-01

    phenomenon could make the navigator change ship’s speed and heading, and these remedial actions could make the vessel escape the bifurcation. This chapter proposes non-parametric methods to detect the onset of parametric roll resonance. Theoretical conditions for parametric resonance are re...... on experimental data from towing tank tests and data from a container ship passing an Atlantic storm....

  7. Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice.

    Science.gov (United States)

    Overhoff, Felix; Brendel, Matthias; Jaworska, Anna; Korzhova, Viktoria; Delker, Andreas; Probst, Federico; Focke, Carola; Gildehaus, Franz-Josef; Carlsen, Janette; Baumann, Karlheinz; Haass, Christian; Bartenstein, Peter; Herms, Jochen; Rominger, Axel

    2016-01-01

    Preclinical PET studies of β-amyloid (Aβ) accumulation are of growing importance, but comparisons between research sites require standardized and optimized methods for quantitation. Therefore, we aimed to evaluate systematically the (1) impact of an automated algorithm for spatial brain normalization, and (2) intensity scaling methods of different reference regions for Aβ-PET in a large dataset of transgenic mice. PS2APP mice in a 6 week longitudinal setting (N = 37) and another set of PS2APP mice at a histologically assessed narrow range of Aβ burden (N = 40) were investigated by [(18)F]-florbetaben PET. Manual spatial normalization by three readers at different training levels was performed prior to application of an automated brain spatial normalization and inter-reader agreement was assessed by Fleiss Kappa (κ). For this method the impact of templates at different pathology stages was investigated. Four different reference regions on brain uptake normalization were used to calculate frontal cortical standardized uptake value ratios (SUVRCTX∕REF), relative to raw SUVCTX. Results were compared on the basis of longitudinal stability (Cohen's d), and in reference to gold standard histopathological quantitation (Pearson's R). Application of an automated brain spatial normalization resulted in nearly perfect agreement (all κ≥0.99) between different readers, with constant or improved correlation with histology. Templates based on inappropriate pathology stage resulted in up to 2.9% systematic bias for SUVRCTX∕REF. All SUVRCTX∕REF methods performed better than SUVCTX both with regard to longitudinal stability (d≥1.21 vs. d = 0.23) and histological gold standard agreement (R≥0.66 vs. R≥0.31). Voxel-wise analysis suggested a physiologically implausible longitudinal decrease by global mean scaling. The hindbrain white matter reference (R mean = 0.75) was slightly superior to the brainstem (R mean = 0.74) and the cerebellum (R mean = 0.73). Automated

  8. Interactive Dimensioning of Parametric Models

    KAUST Repository

    Kelly, T.

    2015-06-22

    We propose a solution for the dimensioning of parametric and procedural models. Dimensioning has long been a staple of technical drawings, and we present the first solution for interactive dimensioning: A dimension line positioning system that adapts to the view direction, given behavioral properties. After proposing a set of design principles for interactive dimensioning, we describe our solution consisting of the following major components. First, we describe how an author can specify the desired interactive behavior of a dimension line. Second, we propose a novel algorithm to place dimension lines at interactive speeds. Third, we introduce multiple extensions, including chained dimension lines, controls for different parameter types (e.g. discrete choices, angles), and the use of dimension lines for interactive editing. Our results show the use of dimension lines in an interactive parametric modeling environment for architectural, botanical, and mechanical models.

  9. Parametric Optimization of Hospital Design

    DEFF Research Database (Denmark)

    Holst, Malene Kirstine; Kirkegaard, Poul Henning; Christoffersen, L.D.

    2013-01-01

    Present paper presents a parametric performancebased design model for optimizing hospital design. The design model operates with geometric input parameters defining the functional requirements of the hospital and input parameters in terms of performance objectives defining the design requirements...... and preferences of the hospital with respect to performances. The design model takes point of departure in the hospital functionalities as a set of defined parameters and rules describing the design requirements and preferences....

  10. Parametric decay of the curvaton

    International Nuclear Information System (INIS)

    Enqvist, K; Nurmi, S; Rigopoulos, G I

    2008-01-01

    We argue that the curvaton decay takes place most naturally by way of a broad parametric resonance. The mechanism is analogous to resonant inflaton decay but does not require any tuning of the curvaton coupling strength to other scalar fields. For low scale inflation and a correspondingly low mass scale for the curvaton, we speculate on observable consequences including the possibility of stochastic gravitational waves

  11. Introduction to the ANSYS Parametric Design Language (APDL)

    CERN Document Server

    Strain, Jeff; Miller, Eric

    2013-01-01

    The definitive guide to the ANSYS Parametric Design Language (APDL), the command language for the ANSYS Mechanical APDL product from ANSYS, Inc. PADT has converted their popular "Introduction to APDL" class into a guide so that users can teach themselves the APDL language at their own pace. Its 12 chapters include reference information, examples, tips and hints, and eight workshops. Topics covered include: - Parameters - User Interfacing - Program Flow - Retrieving Database Information - Arrays, Tables, and Strings - Importing Data - Writing Output to Files - Menu Customization

  12. Bone to pick: the importance of evaluating reference genes for RT-qPCR quantification of gene expression in craniosynostosis and bone-related tissues and cells

    Directory of Open Access Journals (Sweden)

    Yang Xianxian

    2012-05-01

    Full Text Available Abstract Background RT-qPCR is a common tool for quantification of gene expression, but its accuracy is dependent on the choice and stability (steady state expression levels of the reference gene/s used for normalization. To date, in the bone field, there have been few studies to determine the most stable reference genes and, usually, RT-qPCR data is normalised to non-validated reference genes, most commonly GAPDH, ACTB and 18 S rRNA. Here we draw attention to the potential deleterious impact of using classical reference genes to normalise expression data for bone studies without prior validation of their stability. Results Using the geNorm and Normfinder programs, panels of mouse and human genes were assessed for their stability under three different experimental conditions: 1 disease progression of Crouzon syndrome (craniosynostosis in a mouse model, 2 proliferative culture of cranial suture cells isolated from craniosynostosis patients and 3 osteogenesis of a mouse bone marrow stromal cell line. We demonstrate that classical reference genes are not always the most ‘stable’ genes and that gene ‘stability’ is highly dependent on experimental conditions. Selected stable genes, individually or in combination, were then used to normalise osteocalcin and alkaline phosphatase gene expression data during cranial suture fusion in the craniosynostosis mouse model and strategies compared. Strikingly, the expression trends of alkaline phosphatase and osteocalcin varied significantly when normalised to the least stable, the most stable or the three most stable genes. Conclusion To minimise errors in evaluating gene expression levels, analysis of a reference panel and subsequent normalization to several stable genes is strongly recommended over normalization to a single gene. In particular, we conclude that use of single, non-validated “housekeeping” genes such as GAPDH, ACTB and 18 S rRNA, currently a widespread practice by researchers in

  13. Digital spectral analysis parametric, non-parametric and advanced methods

    CERN Document Server

    Castanié, Francis

    2013-01-01

    Digital Spectral Analysis provides a single source that offers complete coverage of the spectral analysis domain. This self-contained work includes details on advanced topics that are usually presented in scattered sources throughout the literature.The theoretical principles necessary for the understanding of spectral analysis are discussed in the first four chapters: fundamentals, digital signal processing, estimation in spectral analysis, and time-series models.An entire chapter is devoted to the non-parametric methods most widely used in industry.High resolution methods a

  14. Bim and Gis: when Parametric Modeling Meets Geospatial Data

    Science.gov (United States)

    Barazzetti, L.; Banfi, F.

    2017-12-01

    Geospatial data have a crucial role in several projects related to infrastructures and land management. GIS software are able to perform advanced geospatial analyses, but they lack several instruments and tools for parametric modelling typically available in BIM. At the same time, BIM software designed for buildings have limited tools to handle geospatial data. As things stand at the moment, BIM and GIS could appear as complementary solutions, notwithstanding research work is currently under development to ensure a better level of interoperability, especially at the scale of the building. On the other hand, the transition from the local (building) scale to the infrastructure (where geospatial data cannot be neglected) has already demonstrated that parametric modelling integrated with geoinformation is a powerful tool to simplify and speed up some phases of the design workflow. This paper reviews such mixed approaches with both simulated and real examples, demonstrating that integration is already a reality at specific scales, which are not dominated by "pure" GIS or BIM. The paper will also demonstrate that some traditional operations carried out with GIS software are also available in parametric modelling software for BIM, such as transformation between reference systems, DEM generation, feature extraction, and geospatial queries. A real case study is illustrated and discussed to show the advantage of a combined use of both technologies. BIM and GIS integration can generate greater usage of geospatial data in the AECOO (Architecture, Engineering, Construction, Owner and Operator) industry, as well as new solutions for parametric modelling with additional geoinformation.

  15. BIM AND GIS: WHEN PARAMETRIC MODELING MEETS GEOSPATIAL DATA

    Directory of Open Access Journals (Sweden)

    L. Barazzetti

    2017-12-01

    Full Text Available Geospatial data have a crucial role in several projects related to infrastructures and land management. GIS software are able to perform advanced geospatial analyses, but they lack several instruments and tools for parametric modelling typically available in BIM. At the same time, BIM software designed for buildings have limited tools to handle geospatial data. As things stand at the moment, BIM and GIS could appear as complementary solutions, notwithstanding research work is currently under development to ensure a better level of interoperability, especially at the scale of the building. On the other hand, the transition from the local (building scale to the infrastructure (where geospatial data cannot be neglected has already demonstrated that parametric modelling integrated with geoinformation is a powerful tool to simplify and speed up some phases of the design workflow. This paper reviews such mixed approaches with both simulated and real examples, demonstrating that integration is already a reality at specific scales, which are not dominated by “pure” GIS or BIM. The paper will also demonstrate that some traditional operations carried out with GIS software are also available in parametric modelling software for BIM, such as transformation between reference systems, DEM generation, feature extraction, and geospatial queries. A real case study is illustrated and discussed to show the advantage of a combined use of both technologies. BIM and GIS integration can generate greater usage of geospatial data in the AECOO (Architecture, Engineering, Construction, Owner and Operator industry, as well as new solutions for parametric modelling with additional geoinformation.

  16. Influence of Variable Acceleration on Parametric Roll Motion of a Container Ship

    Directory of Open Access Journals (Sweden)

    Emre PEŞMAN

    2016-09-01

    Full Text Available Ship operators increase or decrease thrust force of ships to avoid parametric roll motion. These operations cause varying acceleration values. In this study, influence of variable acceleration and deceleration of ships on roll motion is investigated in longitudinal waves. The method which is referred as simple model is utilized for analysis. Simple Model is one degree of freedom nonlinear parametric roll motion equation which contains changing velocity and restoring moment in waves with respect to time. Ship velocities in waves are predicted by XFlow software for various thrust forces. Results indicate that variable acceleration has significant effect on parametric roll phenomenon.

  17. Wind‐gust parametrizations at heights relevant for wind energy: a study based on mast observations

    DEFF Research Database (Denmark)

    Suomi, I.; Vihma, T.; Gryning, Sven-Erik

    2013-01-01

    Wind gusts are traditionally observed and reported at the reference height of 10 m and most gust parametrization methods have been developed only for this height. In many practical applications, e.g. in wind energy, the relevant heights are, however, up to a few hundred metres. In this study, mean...... speed, which is parametrized on the basis of the surface friction velocity, the Obukhov length and height and the boundary‐layer height. The new gust parametrization method outperformed the two older methods: the effects of surface roughness, stability and the height above the surface were well...

  18. Parametric Verification of Weighted Systems

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Hansen, Mikkel; Mariegaard, Anders

    2015-01-01

    are themselves indexed with linear equations. The parameters change the model-checking problem into a problem of computing a linear system of inequalities that characterizes the parameters that guarantee the satisfiability. To address this problem, we use parametric dependency graphs (PDGs) and we propose...... a global update function that yields an assignment to each node in a PDG. For an iterative application of the function, we prove that a fixed point assignment to PDG nodes exists and the set of assignments constitutes a well-quasi ordering, thus ensuring that the fixed point assignment can be found after...

  19. Parametric Sensibility in Lixiviation Reactors

    Directory of Open Access Journals (Sweden)

    Dra. Margarita Rivera-Soto

    2015-11-01

    Full Text Available This work presents the results obtained in an analysis of the parametric sensibility, on the base of a mathematical model, which describes the behavior a lixiviation reactors battery inside the limits of the habitual work of the industrial plant, in a concrete process and of high complexity. The analysis was carried out with the purpose of determining the effect that the changes in different operation variables have on the behavior of the system and it gave as result that the most important variables are: the mineral-acid relationship, the concentration of magnesium and of nickel.

  20. Intraoperative radiotherapy in combination with misonidazole. In special reference to the drug concentration in tumors and normal tissues and to the initial effect of the treatment

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Masaji; Ono, Kouji; Hamanaka, Daizaburo; Dodo, Yoshihiro; Hiraoka, Masahiro [Kyoto Univ. (Japan). Faculty of Medicine

    1983-03-01

    A hypoxic cell radiosensitizer, misonidazole, was applied to 28 patients with carcinoma who received intraoperative radiotherapy. A single dose of 2-3g/m/sup 2/ of the drug was given orally to each patient three hours prior to the start of general anesthesia. The levels of misonidazole and its metabolite, desmethylmisonidazole, in blood, tumors and normal tissues taken from excised materials were measured by a high performance liquid chromatography. The results showed that the concentration levels of misonidazole and desmethylmisonidazole in blood correlated neither to oral doses of 2-3g/m/sup 2/ nor to the function of time after drug ingestion until eight hours. The mean value of blood levels was 77.1 +- 10.9..mu..g/ml. A wide range of 10-96% of the blood level was found in tumors. High levels were observed in gastric cancer and brain tumor (glioblastoma) but not in colorectal cancer and osteosarcoma. It was, however, likely that the concentrations in tumors depended on tumor sizes and/or necrotic areas rather than histologic types and/or sites of tumors. It was also noted that the concentration in normal tissues ranged widely from 11 to 87% of the blood level. Higher concentrations showing more than 75% were found in the ulnar nerve, the stomach and the skin. However, 3 of 4 materials for the stomach and 2 of 3 materials for the skin showed low levels of less than 30% and less than 22% respectively. In 27 of 28 cases different doses of 28-50 Gy with different energies of electrons were delivered intraoperatively. It is impossible so far to derive conclusive results of this study, really because of the short period of observation following the treatment.

  1. Plant tissue culture techniques

    Directory of Open Access Journals (Sweden)

    Rolf Dieter Illg

    1991-01-01

    Full Text Available Plant cell and tissue culture in a simple fashion refers to techniques which utilize either single plant cells, groups of unorganized cells (callus or organized tissues or organs put in culture, under controlled sterile conditions.

  2. Parametric nanomechanical amplification at very high frequency.

    Science.gov (United States)

    Karabalin, R B; Feng, X L; Roukes, M L

    2009-09-01

    Parametric resonance and amplification are important in both fundamental physics and technological applications. Here we report very high frequency (VHF) parametric resonators and mechanical-domain amplifiers based on nanoelectromechanical systems (NEMS). Compound mechanical nanostructures patterned by multilayer, top-down nanofabrication are read out by a novel scheme that parametrically modulates longitudinal stress in doubly clamped beam NEMS resonators. Parametric pumping and signal amplification are demonstrated for VHF resonators up to approximately 130 MHz and provide useful enhancement of both resonance signal amplitude and quality factor. We find that Joule heating and reduced thermal conductance in these nanostructures ultimately impose an upper limit to device performance. We develop a theoretical model to account for both the parametric response and nonequilibrium thermal transport in these composite nanostructures. The results closely conform to our experimental observations, elucidate the frequency and threshold-voltage scaling in parametric VHF NEMS resonators and sensors, and establish the ultimate sensitivity limits of this approach.

  3. Parametric Study of Sealant Nozzle

    Science.gov (United States)

    Yamamoto, Yoshimi

    It has become apparent in recent years the advancement of manufacturing processes in the aerospace industry. Sealant nozzles are a critical device in the use of fuel tank applications for optimal bonds and for ground service support and repair. Sealants has always been a challenging area for optimizing and understanding the flow patterns. A parametric study was conducted to better understand geometric effects of sealant flow and to determine whether the sealant rheology can be numerically modeled. The Star-CCM+ software was used to successfully develop the parametric model, material model, physics continua, and simulate the fluid flow for the sealant nozzle. The simulation results of Semco sealant nozzles showed the geometric effects of fluid flow patterns and the influences from conical area reduction, tip length, inlet diameter, and tip angle parameters. A smaller outlet diameter induced maximum outlet velocity at the exit, and contributed to a high pressure drop. The conical area reduction, tip angle and inlet diameter contributed most to viscosity variation phenomenon. Developing and simulating 2 different flow models (Segregated Flow and Viscous Flow) proved that both can be used to obtain comparable velocity and pressure drop results, however; differences are seen visually in the non-uniformity of the velocity and viscosity fields for the Viscous Flow Model (VFM). A comprehensive simulation setup for sealant nozzles was developed so other analysts can utilize the data.

  4. Parametric and Non-Parametric Vibration-Based Structural Identification Under Earthquake Excitation

    Science.gov (United States)

    Pentaris, Fragkiskos P.; Fouskitakis, George N.

    2014-05-01

    ]. Preliminary results indicate that parametric methods are capable of sufficiently providing the structural/modal characteristics such as natural frequencies and damping ratios. The study also aims - at a further level of investigation - to provide a reliable statistically-based methodology for structural health monitoring after major seismic events which potentially cause harming consequences in structures. Acknowledgments This work was supported by the State Scholarships Foundation of Hellas. References [1] J. S. Sakellariou and S. D. Fassois, "Stochastic output error vibration-based damage detection and assessment in structures under earthquake excitation," Journal of Sound and Vibration, vol. 297, pp. 1048-1067, 2006. [2] G. Hloupis, I. Papadopoulos, J. P. Makris, and F. Vallianatos, "The South Aegean seismological network - HSNC," Adv. Geosci., vol. 34, pp. 15-21, 2013. [3] F. P. Pentaris, J. Stonham, and J. P. Makris, "A review of the state-of-the-art of wireless SHM systems and an experimental set-up towards an improved design," presented at the EUROCON, 2013 IEEE, Zagreb, 2013. [4] S. D. Fassois, "Parametric Identification of Vibrating Structures," in Encyclopedia of Vibration, S. G. Braun, D. J. Ewins, and S. S. Rao, Eds., ed London: Academic Press, London, 2001. [5] S. D. Fassois and J. S. Sakellariou, "Time-series methods for fault detection and identification in vibrating structures," Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 365, pp. 411-448, February 15 2007.

  5. A general approach to optomechanical parametric instabilities

    International Nuclear Information System (INIS)

    Evans, M.; Barsotti, L.; Fritschel, P.

    2010-01-01

    We present a simple feedback description of parametric instabilities which can be applied to a variety of optical systems. Parametric instabilities are of particular interest to the field of gravitational-wave interferometry where high mechanical quality factors and a large amount of stored optical power have the potential for instability. In our use of Advanced LIGO as an example application, we find that parametric instabilities, if left unaddressed, present a potential threat to the stability of high-power operation.

  6. Connections between classical and parametric network entropies.

    Directory of Open Access Journals (Sweden)

    Matthias Dehmer

    Full Text Available This paper explores relationships between classical and parametric measures of graph (or network complexity. Classical measures are based on vertex decompositions induced by equivalence relations. Parametric measures, on the other hand, are constructed by using information functions to assign probabilities to the vertices. The inequalities established in this paper relating classical and parametric measures lay a foundation for systematic classification of entropy-based measures of graph complexity.

  7. Parametric study on the behaviour of bolted composite connections

    Directory of Open Access Journals (Sweden)

    M. N. Kataoka

    Full Text Available The studied connections are composed of concrete filled steel tubes (CFT connected to composite beams by passing through bolts, endplates and steel deck, which also contributes to support the applied loads. The parametric analysis presented in this work is based on numerical simulations performed with software TNO Diana, using experimental results to calibrate the reference numerical model. The influence of three main parameters, being them the bolts diameter, the slab height and the beams cross section, was evaluated. According to the obtained bending moment versus rotation curves, it was concluded that, among the three parameters analyzed, the most important one was the bolts diameter. About the beams cross section, inconclusive results were achieved, probably due to the incompatibility between the 16 mm bolts and the robust beam cross sections considered in the parametric analysis.

  8. On the parametrization of lateral dose profiles in proton radiation therapy

    CERN Document Server

    Embriaco, A

    2015-01-01

    Hadrontherapy requires a good knowledge of the physical interactions of the particles when they cross the biological tissue: one of the aspects that determine the characterization of the beam is the study of the lateral profile. We study different parametrizations for the lateral dose profile of protons beam in water considering different energies at different depth. We compare six functions: we start from the well known Gaussian and Double Gaussian parametrizations and also analyse more recent parametrization obtained with Triple Gaussian and Double Gaussian Lorentz-Cauchy functions. Finally we propose alternative parametrizations based on the Gauss-Rutherford and Gauss-Levy functions. The goal is to improve the performances of the actual treatment planning used in proton beam therapy by suggesting alternative approaches to the Gaussian description typically employed.

  9. Design of parametric software tools

    DEFF Research Database (Denmark)

    Sabra, Jakob Borrits; Mullins, Michael

    2011-01-01

    The studies investigate the field of evidence-based design used in architectural design practice and propose a method using 2D/3D CAD applications to: 1) enhance integration of evidence-based design knowledge in architectural design phases with a focus on lighting and interior design and 2) assess...... fulfilment of evidence-based design criterion regarding light distribution and location in relation to patient safety in architectural health care design proposals. The study uses 2D/3D CAD modelling software Rhinoceros 3D with plug-in Grasshopper to create parametric tool prototypes to exemplify...... the operations and functions of the design method. To evaluate the prototype potentials, surveys with architectural and healthcare design companies are conducted. Evaluation is done by the administration of questionnaires being part of the development of the tools. The results show that architects, designers...

  10. Parametric instabilities in large plasmas

    International Nuclear Information System (INIS)

    Brambilla, Marco; Liberman, Bernardo.

    1979-01-01

    Parametric decay processes in large plasmas are considered as the linear stage of a three wave interaction (pump, sideband and beat wave) in which the amplitude of the externally excited pump is sufficiently large to neglect pump depletion to first order, yet sufficiently small to allow a linearized treatment of the pump propagation to zeroth order. The coupling coefficients are then obtained from an iterative solution of Vlasov equation, and a compact expression is derived, in which the multiple series over Bessel functions is explicitly summed. Even in the limit of a very long wavelength pump, the dispersion relation obtained in this way does not coincide with the one obtained using the well-known ''dipole'' approximation, unless both the sideband and beat wave are resonant modes of the plasma. An analysis of the origin of this discrepancy allows us to conclude that ''quasimodes'' (evanescent waves driven absolutely unstable by the pump) are more correctly described by the iterative approach

  11. Parametric embedding for class visualization.

    Science.gov (United States)

    Iwata, Tomoharu; Saito, Kazumi; Ueda, Naonori; Stromsten, Sean; Griffiths, Thomas L; Tenenbaum, Joshua B

    2007-09-01

    We propose a new method, parametric embedding (PE), that embeds objects with the class structure into a low-dimensional visualization space. PE takes as input a set of class conditional probabilities for given data points and tries to preserve the structure in an embedding space by minimizing a sum of Kullback-Leibler divergences, under the assumption that samples are generated by a gaussian mixture with equal covariances in the embedding space. PE has many potential uses depending on the source of the input data, providing insight into the classifier's behavior in supervised, semisupervised, and unsupervised settings. The PE algorithm has a computational advantage over conventional embedding methods based on pairwise object relations since its complexity scales with the product of the number of objects and the number of classes. We demonstrate PE by visualizing supervised categorization of Web pages, semisupervised categorization of digits, and the relations of words and latent topics found by an unsupervised algorithm, latent Dirichlet allocation.

  12. Parametric studies on automotive radiators

    International Nuclear Information System (INIS)

    Oliet, C.; Oliva, A.; Castro, J.; Perez-Segarra, C.D.

    2007-01-01

    This paper presents a set of parametric studies performed on automotive radiators by means of a detailed rating and design heat exchanger model developed by the authors. This numerical tool has been previously verified and validated using a wide experimental data bank. A first part of the analysis focuses on the influence of working conditions on both fluids (mass flows, inlet temperatures) and the impact of the selected coolant fluid. Following these studies, the influence of some geometrical parameters is analysed (fin pitch, louver angle) as well as the importance of coolant flow lay-out on the radiator global performance. This work provides an overall behaviour report of automobile radiators working at usual range of operating conditions, while significant knowledge-based design conclusions have also been reported. The results show the utility of this numerical model as a rating and design tool for heat exchangers manufacturers, being a reasonable compromise between classic ε - NTU methods and CFD

  13. Parametric instabilities in inhomogeneous plasma

    International Nuclear Information System (INIS)

    Nicholson, D.R.

    1975-01-01

    The nonlinear coupling of three waves in a plasma is considered. One of the waves is assumed large and constant; its amplitude is the parameter of the parametric instability. The spatial-temporal evolution of the other two waves is treated theoretically, in one dimension, by analytic methods and by direct numerical integration of the basic equations. Various monotonic forms of inhomogeneity are considered; agreement with previous work is found and new results are established. Nonmonotonic inhomogeneities are considered, in the form of turbulence and, as a model problem, in the form of a simple sinusoidal modulation. Relatively small amounts of nonmonotonic inhomogeneity, in the presence of a linear density gradient, are found to destabilize the well-known convective saturation, absolute growth occurring instead. (U.S.)

  14. Growth references

    NARCIS (Netherlands)

    Buuren, S. van

    2007-01-01

    A growth reference describes the variation of an anthropometric measurement within a group of individuals. A reference is a tool for grouping and analyzing data and provides a common basis for comparing populations.1 A well known type of reference is the age-conditional growth diagram. The

  15. Function parametrization by using 4-point transforms

    International Nuclear Information System (INIS)

    Dikusar, N.D.

    1996-01-01

    A continuous parametrization of the smooth curve f(x)=f(x;R) is suggested on a basis of four-point transformations. Coordinates of three reference points of the curve are chosen as parameters R. This approach allows to derive a number of advantages in function approximation and fitting of empiric data. The transformations have made possible to derive a new class of polynomials (monosplines) having the better approximation quality than monomials {x n }. A behaviour of an error of the approximation has a uniform character. A three-point model of the cubic spline (TPS) is proposed. The model allows to reduce a number of unknown parameters in twice and to obtain an advantage in a computing aspect. The new approach to the function approximation and fitting are shown on a number of examples. The proposed approach gives a new mathematical tool and a new possibility in both practical applications and theoretical research of numerical and computational methods. 13 refs., 13 figs., 2 tabs

  16. Integrable multi parametric SU(N) chain

    International Nuclear Information System (INIS)

    Foerster, Angela; Roditi, Itzhak; Rodrigues, Ligia M.C.S.

    1996-03-01

    We analyse integrable models associated to a multi parametric SU(N) R-matrix. We show that the Hamiltonians describe SU(N) chains with twisted boundary conditions and that the underlying algebraic structure is the multi parametric deformation of SU(N) enlarged by the introduction of a central element. (author). 15 refs

  17. Observation of Parametric Instability in Advanced LIGO.

    Science.gov (United States)

    Evans, Matthew; Gras, Slawek; Fritschel, Peter; Miller, John; Barsotti, Lisa; Martynov, Denis; Brooks, Aidan; Coyne, Dennis; Abbott, Rich; Adhikari, Rana X; Arai, Koji; Bork, Rolf; Kells, Bill; Rollins, Jameson; Smith-Lefebvre, Nicolas; Vajente, Gabriele; Yamamoto, Hiroaki; Adams, Carl; Aston, Stuart; Betzweiser, Joseph; Frolov, Valera; Mullavey, Adam; Pele, Arnaud; Romie, Janeen; Thomas, Michael; Thorne, Keith; Dwyer, Sheila; Izumi, Kiwamu; Kawabe, Keita; Sigg, Daniel; Derosa, Ryan; Effler, Anamaria; Kokeyama, Keiko; Ballmer, Stefan; Massinger, Thomas J; Staley, Alexa; Heinze, Matthew; Mueller, Chris; Grote, Hartmut; Ward, Robert; King, Eleanor; Blair, David; Ju, Li; Zhao, Chunnong

    2015-04-24

    Parametric instabilities have long been studied as a potentially limiting effect in high-power interferometric gravitational wave detectors. Until now, however, these instabilities have never been observed in a kilometer-scale interferometer. In this Letter, we describe the first observation of parametric instability in a gravitational wave detector, and the means by which it has been removed as a barrier to progress.

  18. Parametric Methods for Order Tracking Analysis

    DEFF Research Database (Denmark)

    Nielsen, Jesper Kjær; Jensen, Tobias Lindstrøm

    2017-01-01

    Order tracking analysis is often used to find the critical speeds at which structural resonances are excited by a rotating machine. Typically, order tracking analysis is performed via non-parametric methods. In this report, however, we demonstrate some of the advantages of using a parametric method...

  19. Parametric resonance in neutrino oscillations in matter

    Indian Academy of Sciences (India)

    Neutrino oscillations in matter can exhibit a specific resonance enhancement - parametric resonance, which is different from the MSW resonance. Oscillations of atmospheric and solar neutrinos inside the earth can undergo parametric enhancement when neutrino trajectories cross the core of the earth. In this paper we ...

  20. On the parametric approximation in quantum optics

    Energy Technology Data Exchange (ETDEWEB)

    D' Ariano, G.M.; Paris, M.G.A.; Sacchi, M.F. [Istituto Nazionale di Fisica Nucleare, Pavia (Italy); Pavia Univ. (Italy). Dipt. di Fisica ' Alessandro Volta'

    1999-03-01

    The authors perform the exact numerical diagonalization of Hamiltonians that describe both degenerate and nondegenerate parametric amplifiers, by exploiting the conservation laws pertaining each device. It is clarify the conditions under which the parametric approximation holds, showing that the most relevant requirements is the coherence of the pump after the interaction, rather than its un depletion.

  1. On the parametric approximation in quantum optics

    International Nuclear Information System (INIS)

    D'Ariano, G.M.; Paris, M.G.A.; Sacchi, M.F.; Pavia Univ.

    1999-01-01

    The authors perform the exact numerical diagonalization of Hamiltonians that describe both degenerate and nondegenerate parametric amplifiers, by exploiting the conservation laws pertaining each device. It is clarify the conditions under which the parametric approximation holds, showing that the most relevant requirements is the coherence of the pump after the interaction, rather than its un depletion

  2. Parametric form of QCD travelling waves

    OpenAIRE

    Peschanski, R.

    2005-01-01

    We derive parametric travelling-wave solutions of non-linear QCD equations. They describe the evolution towards saturation in the geometric scaling region. The method, based on an expansion in the inverse of the wave velocity, leads to a solvable hierarchy of differential equations. A universal parametric form of travelling waves emerges from the first two orders of the expansion.

  3. Developing a Parametric Urban Design Tool

    DEFF Research Database (Denmark)

    Steinø, Nicolai; Obeling, Esben

    2014-01-01

    Parametric urban design is a potentially powerful tool for collaborative urban design processes. Rather than making one- off designs which need to be redesigned from the ground up in case of changes, parametric design tools make it possible keep the design open while at the same time allowing...... for a level of detailing which is high enough to facilitate an understan- ding of the generic qualities of proposed designs. Starting from a brief overview of parametric design, this paper presents initial findings from the development of a parametric urban design tool with regard to developing a structural...... logic which is flexible and expandable. It then moves on to outline and discuss further development work. Finally, it offers a brief reflection on the potentials and shortcomings of the software – CityEngine – which is used for developing the parametric urban design tool....

  4. Biomedical Engineering Desk Reference

    CERN Document Server

    Ratner, Buddy D; Schoen, Frederick J; Lemons, Jack E; Dyro, Joseph; Martinsen, Orjan G; Kyle, Richard; Preim, Bernhard; Bartz, Dirk; Grimnes, Sverre; Vallero, Daniel; Semmlow, John; Murray, W Bosseau; Perez, Reinaldo; Bankman, Isaac; Dunn, Stanley; Ikada, Yoshito; Moghe, Prabhas V; Constantinides, Alkis

    2009-01-01

    A one-stop Desk Reference, for Biomedical Engineers involved in the ever expanding and very fast moving area; this is a book that will not gather dust on the shelf. It brings together the essential professional reference content from leading international contributors in the biomedical engineering field. Material covers a broad range of topics including: Biomechanics and Biomaterials; Tissue Engineering; and Biosignal Processing* A hard-working desk reference providing all the essential material needed by biomedical and clinical engineers on a day-to-day basis * Fundamentals, key techniques,

  5. Ionization Cooling using Parametric Resonances

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Rolland P.

    2008-06-07

    Ionization Cooling using Parametric Resonances was an SBIR project begun in July 2004 and ended in January 2008 with Muons, Inc., (Dr. Rolland Johnson, PI), and Thomas Jefferson National Accelerator Facility (JLab) (Dr. Yaroslav Derbenev, Subcontract PI). The project was to develop the theory and simulations of Parametric-resonance Ionization Cooling (PIC) so that it could be used to provide the extra transverse cooling needed for muon colliders in order to relax the requirements on the proton driver, reduce the site boundary radiation, and provide a better environment for experiments. During the course of the project, the theoretical understanding of PIC was developed and a final exposition is ready for publication. Workshops were sponsored by Muons, Inc. in May and September of 2007 that were devoted to the PIC technique. One outcome of the workshops was the interesting and somewhat unexpected realization that the beam emittances using the PIC technique can get small enough that space charge forces can be important. A parallel effort to develop our G4beamline simulation program to include space charge effects was initiated to address this problem. A method of compensating for chromatic aberrations by employing synchrotron motion was developed and simulated. A method of compensating for spherical aberrations using beamline symmetry was also developed and simulated. Different optics designs have been developed using the OptiM program in preparation for applying our G4beamline simulation program, which contains all the power of the Geant4 toolkit. However, no PIC channel design that has been developed has had the desired cooling performance when subjected to the complete G4beamline simulation program. This is believed to be the consequence of the difficulties of correcting the aberrations associated with the naturally large beam angles and beam sizes of the PIC method that are exacerbated by the fringe fields of the rather complicated channel designs that have been

  6. Ionization Cooling using Parametric Resonances

    International Nuclear Information System (INIS)

    Johnson, Rolland P.

    2008-01-01

    Ionization Cooling using Parametric Resonances was an SBIR project begun in July 2004 and ended in January 2008 with Muons, Inc., (Dr. Rolland Johnson, PI), and Thomas Jefferson National Accelerator Facility (JLab) (Dr. Yaroslav Derbenev, Subcontract PI). The project was to develop the theory and simulations of Parametric-resonance Ionization Cooling (PIC) so that it could be used to provide the extra transverse cooling needed for muon colliders in order to relax the requirements on the proton driver, reduce the site boundary radiation, and provide a better environment for experiments. During the course of the project, the theoretical understanding of PIC was developed and a final exposition is ready for publication. Workshops were sponsored by Muons, Inc. in May and September of 2007 that were devoted to the PIC technique. One outcome of the workshops was the interesting and somewhat unexpected realization that the beam emittances using the PIC technique can get small enough that space charge forces can be important. A parallel effort to develop our G4beamline simulation program to include space charge effects was initiated to address this problem. A method of compensating for chromatic aberrations by employing synchrotron motion was developed and simulated. A method of compensating for spherical aberrations using beamline symmetry was also developed and simulated. Different optics designs have been developed using the OptiM program in preparation for applying our G4beamline simulation program, which contains all the power of the Geant4 toolkit. However, no PIC channel design that has been developed has had the desired cooling performance when subjected to the complete G4beamline simulation program. This is believed to be the consequence of the difficulties of correcting the aberrations associated with the naturally large beam angles and beam sizes of the PIC method that are exacerbated by the fringe fields of the rather complicated channel designs that have been

  7. [Reference citation].

    Science.gov (United States)

    Brkić, Silvija

    2013-01-01

    Scientific and professional papers represent the information basis for scientific research and professional work. References important for the paper should be cited within the text, and listed at the end of the paper. This paper deals with different styles of reference citation. Special emphasis was placed on the Vancouver Style for reference citation in biomedical journals established by the International Committee of Medical Journal Editors. It includes original samples for citing various types of articles, both printed and electronic, as well as recommendations related to reference citation in accordance with the methodology and ethics of scientific research and guidelines for preparing manuscripts for publication.

  8. Polyaffine parametrization of image registration based on geodesic flows

    DEFF Research Database (Denmark)

    Hansen, Michael Sass; Thorup, Signe Strann; Warfield, Simon K.

    2012-01-01

    Image registration based on geodesic flows has gained much popularity in recent years. We describe a novel parametrization of the velocity field in a stationary flow equation. We show that the method offers both precision, flexibility, and simplicity of evaluation. With our representation, which ...... of geodesic shooting for computational anatomy. We avoid to do warp field convolution by interpolation in a dense field, we can easily calculate warp derivatives in a reference frame of choice, and we can consequently avoid interpolation in the image space altogether....

  9. Introduction to the ANSYS Parametric Design Language (APDL)

    CERN Document Server

    Strain, Jeff

    2016-01-01

    The definitive guide to the ANSYS Parametric Design Language (APDL), the command language for the ANSYS Mechanical APDL product from ANSYS, Inc. PADT has converted their popular "Introduction to APDL" class into a guide so that users can teach themselves the APDL language at their own pace. Its 14 chapters include reference information, examples, tips and hints, and eight workshops. Topics covered include: - Parameters - User Interfacing - Program Flow - Retrieving Database Information - Arrays, Tables, and Strings - Importing Data - Writing Output to Files - Menu Customization - APDL Math - Using APDL in ANSYS Mechanical

  10. Anal submucosal injection: a new route for drug administration in pelvic malignancies. Part I. Experimental study of misonidazole distribution in serum and tissues, with special reference to urinary bladder. Preliminary report

    International Nuclear Information System (INIS)

    Shafik, A.; el-Merzabani, M.M.; el-Aaser, A.A.; el-Desouky, G.H.

    1986-01-01

    The anal and oral administration routes were compared in 30 rats to study the distribution of misonidazole, a radiation sensitizer, in the serum and tissues with special reference to the urinary bladder. 14C-labelled misonidazole was administered in a dose of 0.2 ml water/100 gm body weight containing 1 mu Ci misonidazole. The dose was given orally by stomach tube in 15 rats, and was injected in the submucosa of the anal canal in another 15. Animals were then killed after 15, 30, 60, or 120 minutes or after 24 hours. Organs were dissected, and radioactivity was determined in each by the internal standard method. The study has shown that the highest drug concentration in the bladder tissue relative to the serum was achieved with the anal submucosal route. Its level was eight and five times that of the serum 15 and 30 minutes after administration, respectively, in contrast to the oral route in which the drug concentration was one-quarter and equal to the serum level at the same time intervals. The anal route would thus provide the adequate channel required for misonidazole to promote radiation responsiveness in bladder carcinoma

  11. MicroRNAs are suitable for assessment as biomarkers from formalin-fixed paraffin-embedded tissue, and miR-24 represents an appropriate reference microRNA for diffuse large B-cell lymphoma studies.

    Science.gov (United States)

    Culpin, Rachel Emily; Sieniawski, Michal; Proctor, Stephen John; Menon, Geetha; Mainou-Fowler, Tryfonia

    2013-03-01

    Tissue biopsy specimens in the form of formalin-fixed paraffin-embedded tissue (FFPET) represent a valuable resource for biomarker identification and validation. However, to date, they remain an underused asset due to uncertainty regarding RNA extraction and the reliability of downstream techniques, including quantitative RT-PCR. Recently, much interest has emerged in the study of microRNAs; small single-stranded RNAs with a role in transcriptional regulation, that are thought to be well preserved in FFPET. In this study, we show that microRNA expression is comparable between FFPET and matched fresh-frozen samples (miR-17-5p: p=0.01, miR-92: p=0.003), and demonstrate that no significant deterioration in expression occurs over prolonged FFPET storage (p=0.06). Furthermore, microRNA expression is equivalent dependant on RNA extraction method (p<0.001) or DNAse treatment of total RNA (p<0.001). Finally, we validate miR-24 as a suitable reference microRNA for diffuse large B-cell lymphoma (DLBCL) FFPET studies.

  12. Controlling flexible rotor vibrations using parametric excitation

    Energy Technology Data Exchange (ETDEWEB)

    Atepor, L, E-mail: katepor@yahoo.co [Department of Mechanical Engineering, University of Glasgow, G12 8QQ (United Kingdom)

    2009-08-01

    This paper presents both theoretical and experimental studies of an active vibration controller for vibration in a flexible rotor system. The paper shows that the vibration amplitude can be modified by introducing an axial parametric excitation. The perturbation method of multiple scales is used to solve the equations of motion. The steady-state responses, with and without the parametric excitation terms, is investigated. An experimental test machine uses a piezoelectric exciter mounted on the end of the shaft. The results show a reduction in the rotor response amplitude under principal parametric resonance, and some good correlation between theory and experiment.

  13. Linear Parametric Model Checking of Timed Automata

    DEFF Research Database (Denmark)

    Hune, Tohmas Seidelin; Romijn, Judi; Stoelinga, Mariëlle

    2001-01-01

    We present an extension of the model checker Uppaal capable of synthesize linear parameter constraints for the correctness of parametric timed automata. The symbolic representation of the (parametric) state-space is shown to be correct. A second contribution of this paper is the identication...... of a subclass of parametric timed automata (L/U automata), for which the emptiness problem is decidable, contrary to the full class where it is know to be undecidable. Also we present a number of lemmas enabling the verication eort to be reduced for L/U automata in some cases. We illustrate our approach...

  14. Reference Assessment

    Science.gov (United States)

    Bivens-Tatum, Wayne

    2006-01-01

    This article presents interesting articles that explore several different areas of reference assessment, including practical case studies and theoretical articles that address a range of issues such as librarian behavior, patron satisfaction, virtual reference, or evaluation design. They include: (1) "Evaluating the Quality of a Chat Service"…

  15. Reference interval computation: which method (not) to choose?

    Science.gov (United States)

    Pavlov, Igor Y; Wilson, Andrew R; Delgado, Julio C

    2012-07-11

    When different methods are applied to reference interval (RI) calculation the results can sometimes be substantially different, especially for small reference groups. If there are no reliable RI data available, there is no way to confirm which method generates results closest to the true RI. We randomly drawn samples obtained from a public database for 33 markers. For each sample, RIs were calculated by bootstrapping, parametric, and Box-Cox transformed parametric methods. Results were compared to the values of the population RI. For approximately half of the 33 markers, results of all 3 methods were within 3% of the true reference value. For other markers, parametric results were either unavailable or deviated considerably from the true values. The transformed parametric method was more accurate than bootstrapping for sample size of 60, very close to bootstrapping for sample size 120, but in some cases unavailable. We recommend against using parametric calculations to determine RIs. The transformed parametric method utilizing Box-Cox transformation would be preferable way of RI calculation, if it satisfies normality test. If not, the bootstrapping is always available, and is almost as accurate and precise as the transformed parametric method. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Recent references

    International Nuclear Information System (INIS)

    Ramavataram, S.

    1991-01-01

    In support of a continuing program of systematic evaluation of nuclear structure data, the National Nuclear Data Center maintains a complete computer file of references to the nuclear physics literature. Each reference is tagged by a keyword string, which indicates the kinds of data contained in the article. This master file of Nuclear Structure References (NSR) contains complete keyword indexes to literature published since 1969, with partial indexing of older references. Any reader who finds errors in the keyword descriptions is urged to report them to the National Nuclear Data Center so that the master NSR file can be corrected. In 1966, the first collection of Recent References was published as a separate issue of Nuclear Data Sheets. Every four months since 1970, a similar indexed bibliography to new nuclear experiments has been prepared from additions to the NSR file and published. Beginning in 1978, Recent References was cumulated annually, with the third issue completely superseding the two issues previously published during a given year. Due to publication policy changes, cumulation of Recent Reference was discontinued in 1986. The volume and issue number of all the cumulative issues published to date are given. NNDC will continue to respond to individual requests for special bibliographies on nuclear physics topics, in addition to those easily obtained from Recent References. If the required information is available from the keyword string, a reference list can be prepared automatically from the computer files. This service can be provided on request, in exchange for the timely communication of new nuclear physics results (e.g., preprints). A current copy of the NSR file may also be obtained in a standard format on magnetic tape from NNDC. Requests for special searches of the NSR file may also be directed to the National Nuclear Data Center

  17. Parametric optimization of inverse trapezoid oleophobic surfaces

    DEFF Research Database (Denmark)

    Cavalli, Andrea; Bøggild, Peter; Okkels, Fridolin

    2012-01-01

    In this paper, we introduce a comprehensive and versatile approach to the parametric shape optimization of oleophobic surfaces. We evaluate the performance of inverse trapezoid microstructures in terms of three objective parameters: apparent contact angle, maximum sustainable hydrostatic pressure...

  18. Parametric decay below the upper hybrid frequency

    Energy Technology Data Exchange (ETDEWEB)

    Albers, E; Krause, K; Schlueter, H [Bochum Univ. (Germany, F.R.). Inst. fuer Experimentalphysik 2

    1977-03-21

    Parametric decay of the upper hybrid mode is observed between the electron cyclotron frequency and its first two harmonics. The decay products are identified as electron Bernstein and ion acoustic mode. The diagnostic results confirm the relevant dispersion relations.

  19. Optimal parametric modelling of measured short waves

    Digital Repository Service at National Institute of Oceanography (India)

    Mandal, S.

    the importance of selecting a suitable sampling interval for better estimates of parametric modelling and also for better statistical representation. Implementation of the above algorithms in a structural monitoring system has the potential advantage of storing...

  20. Robust and Efficient Parametric Face Alignment

    NARCIS (Netherlands)

    Tzimiropoulos, Georgios; Zafeiriou, Stefanos; Pantic, Maja

    2011-01-01

    We propose a correlation-based approach to parametric object alignment particularly suitable for face analysis applications which require efficiency and robustness against occlusions and illumination changes. Our algorithm registers two images by iteratively maximizing their correlation coefficient

  1. Ranking Forestry Investments With Parametric Linear Programming

    Science.gov (United States)

    Paul A. Murphy

    1976-01-01

    Parametric linear programming is introduced as a technique for ranking forestry investments under multiple constraints; it combines the advantages of simple tanking and linear programming as capital budgeting tools.

  2. A Parametric k-Means Algorithm

    Science.gov (United States)

    Tarpey, Thaddeus

    2007-01-01

    Summary The k points that optimally represent a distribution (usually in terms of a squared error loss) are called the k principal points. This paper presents a computationally intensive method that automatically determines the principal points of a parametric distribution. Cluster means from the k-means algorithm are nonparametric estimators of principal points. A parametric k-means approach is introduced for estimating principal points by running the k-means algorithm on a very large simulated data set from a distribution whose parameters are estimated using maximum likelihood. Theoretical and simulation results are presented comparing the parametric k-means algorithm to the usual k-means algorithm and an example on determining sizes of gas masks is used to illustrate the parametric k-means algorithm. PMID:17917692

  3. Parametric resonance in neutrino oscillations in matter

    Indian Academy of Sciences (India)

    specific phase relationships has an interesting property that it can accumulate if the matter .... In Д 3 we discuss the physical interpretation of the parametric reso- nance in neutrino ..... long-baseline accelerator and reactor experiments [12,29].

  4. Parametric resonance in an expanding universe

    International Nuclear Information System (INIS)

    Zlatev, I.; Huey, G.; Steinhardt, P.J.

    1998-01-01

    Parametric resonance has been discussed as a mechanism for copious particle production following inflation. Here we present a simple and intuitive calculational method for estimating the efficiency of parametric amplification as a function of parameters. This is important for determining whether resonant amplification plays an important role in the reheating process. We find that significant amplification occurs only for a limited range of couplings and interactions. copyright 1998 The American Physical Society

  5. Efficiency Analysis of German Electricity Distribution Utilities : Non-Parametric and Parametric Tests

    OpenAIRE

    von Hirschhausen, Christian R.; Cullmann, Astrid

    2005-01-01

    Abstract This paper applies parametric and non-parametric and parametric tests to assess the efficiency of electricity distribution companies in Germany. We address traditional issues in electricity sector benchmarking, such as the role of scale effects and optimal utility size, as well as new evidence specific to the situation in Germany. We use labour, capital, and peak load capacity as inputs, and units sold and the number of customers as output. The data cover 307 (out of 553) ...

  6. Parametric studh on coupling loss in subsize ITER Nb3Sn cabled specimens

    NARCIS (Netherlands)

    Nijhuis, Arend; ten Kate, Herman H.J.; Bruzzone, Pierluigi; Bottura, Luca

    1996-01-01

    The cable in conduit conductors for the various ITER coils are required to function under pulse conditions and fields up to 13 T. A parametric study, restricted to a limited variation of the reference cable lay out, is carried out to clarify the quantitative impact of various cable parameters on the

  7. PHAZE, Parametric Hazard Function Estimation

    International Nuclear Information System (INIS)

    2002-01-01

    1 - Description of program or function: Phaze performs statistical inference calculations on a hazard function (also called a failure rate or intensity function) based on reported failure times of components that are repaired and restored to service. Three parametric models are allowed: the exponential, linear, and Weibull hazard models. The inference includes estimation (maximum likelihood estimators and confidence regions) of the parameters and of the hazard function itself, testing of hypotheses such as increasing failure rate, and checking of the model assumptions. 2 - Methods: PHAZE assumes that the failures of a component follow a time-dependent (or non-homogenous) Poisson process and that the failure counts in non-overlapping time intervals are independent. Implicit in the independence property is the assumption that the component is restored to service immediately after any failure, with negligible repair time. The failures of one component are assumed to be independent of those of another component; a proportional hazards model is used. Data for a component are called time censored if the component is observed for a fixed time-period, or plant records covering a fixed time-period are examined, and the failure times are recorded. The number of these failures is random. Data are called failure censored if the component is kept in service until a predetermined number of failures has occurred, at which time the component is removed from service. In this case, the number of failures is fixed, but the end of the observation period equals the final failure time and is random. A typical PHAZE session consists of reading failure data from a file prepared previously, selecting one of the three models, and performing data analysis (i.e., performing the usual statistical inference about the parameters of the model, with special emphasis on the parameter(s) that determine whether the hazard function is increasing). The final goals of the inference are a point estimate

  8. A generalized parametric response mapping method for analysis of multi-parametric imaging: A feasibility study with application to glioblastoma.

    Science.gov (United States)

    Lausch, Anthony; Yeung, Timothy Pok-Chi; Chen, Jeff; Law, Elton; Wang, Yong; Urbini, Benedetta; Donelli, Filippo; Manco, Luigi; Fainardi, Enrico; Lee, Ting-Yim; Wong, Eugene

    2017-11-01

    Parametric response map (PRM) analysis of functional imaging has been shown to be an effective tool for early prediction of cancer treatment outcomes and may also be well-suited toward guiding personalized adaptive radiotherapy (RT) strategies such as sub-volume boosting. However, the PRM method was primarily designed for analysis of longitudinally acquired pairs of single-parameter image data. The purpose of this study was to demonstrate the feasibility of a generalized parametric response map analysis framework, which enables analysis of multi-parametric data while maintaining the key advantages of the original PRM method. MRI-derived apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) maps acquired at 1 and 3-months post-RT for 19 patients with high-grade glioma were used to demonstrate the algorithm. Images were first co-registered and then standardized using normal tissue image intensity values. Tumor voxels were then plotted in a four-dimensional Cartesian space with coordinate values equal to a voxel's image intensity in each of the image volumes and an origin defined as the multi-parametric mean of normal tissue image intensity values. Voxel positions were orthogonally projected onto a line defined by the origin and a pre-determined response vector. The voxels are subsequently classified as positive, negative or nil, according to whether projected positions along the response vector exceeded a threshold distance from the origin. The response vector was selected by identifying the direction in which the standard deviation of tumor image intensity values was maximally different between responding and non-responding patients within a training dataset. Voxel classifications were visualized via familiar three-class response maps and then the fraction of tumor voxels associated with each of the classes was investigated for predictive utility analogous to the original PRM method. Independent PRM and MPRM analyses of the contrast

  9. Assessing pupil and school performance by non-parametric and parametric techniques

    NARCIS (Netherlands)

    de Witte, K.; Thanassoulis, E.; Simpson, G.; Battisti, G.; Charlesworth-May, A.

    2010-01-01

    This paper discusses the use of the non-parametric free disposal hull (FDH) and the parametric multi-level model (MLM) as alternative methods for measuring pupil and school attainment where hierarchical structured data are available. Using robust FDH estimates, we show how to decompose the overall

  10. Experimental Sentinel-2 LAI estimation using parametric, non-parametric and physical retrieval methods - A comparison

    NARCIS (Netherlands)

    Verrelst, Jochem; Rivera, Juan Pablo; Veroustraete, Frank; Muñoz-Marí, Jordi; Clevers, J.G.P.W.; Camps-Valls, Gustau; Moreno, José

    2015-01-01

    Given the forthcoming availability of Sentinel-2 (S2) images, this paper provides a systematic comparison of retrieval accuracy and processing speed of a multitude of parametric, non-parametric and physically-based retrieval methods using simulated S2 data. An experimental field dataset (SPARC),

  11. A non-parametric peak calling algorithm for DamID-Seq.

    Directory of Open Access Journals (Sweden)

    Renhua Li

    Full Text Available Protein-DNA interactions play a significant role in gene regulation and expression. In order to identify transcription factor binding sites (TFBS of double sex (DSX-an important transcription factor in sex determination, we applied the DNA adenine methylation identification (DamID technology to the fat body tissue of Drosophila, followed by deep sequencing (DamID-Seq. One feature of DamID-Seq data is that induced adenine methylation signals are not assured to be symmetrically distributed at TFBS, which renders the existing peak calling algorithms for ChIP-Seq, including SPP and MACS, inappropriate for DamID-Seq data. This challenged us to develop a new algorithm for peak calling. A challenge in peaking calling based on sequence data is estimating the averaged behavior of background signals. We applied a bootstrap resampling method to short sequence reads in the control (Dam only. After data quality check and mapping reads to a reference genome, the peaking calling procedure compromises the following steps: 1 reads resampling; 2 reads scaling (normalization and computing signal-to-noise fold changes; 3 filtering; 4 Calling peaks based on a statistically significant threshold. This is a non-parametric method for peak calling (NPPC. We also used irreproducible discovery rate (IDR analysis, as well as ChIP-Seq data to compare the peaks called by the NPPC. We identified approximately 6,000 peaks for DSX, which point to 1,225 genes related to the fat body tissue difference between female and male Drosophila. Statistical evidence from IDR analysis indicated that these peaks are reproducible across biological replicates. In addition, these peaks are comparable to those identified by use of ChIP-Seq on S2 cells, in terms of peak number, location, and peaks width.

  12. A non-parametric peak calling algorithm for DamID-Seq.

    Science.gov (United States)

    Li, Renhua; Hempel, Leonie U; Jiang, Tingbo

    2015-01-01

    Protein-DNA interactions play a significant role in gene regulation and expression. In order to identify transcription factor binding sites (TFBS) of double sex (DSX)-an important transcription factor in sex determination, we applied the DNA adenine methylation identification (DamID) technology to the fat body tissue of Drosophila, followed by deep sequencing (DamID-Seq). One feature of DamID-Seq data is that induced adenine methylation signals are not assured to be symmetrically distributed at TFBS, which renders the existing peak calling algorithms for ChIP-Seq, including SPP and MACS, inappropriate for DamID-Seq data. This challenged us to develop a new algorithm for peak calling. A challenge in peaking calling based on sequence data is estimating the averaged behavior of background signals. We applied a bootstrap resampling method to short sequence reads in the control (Dam only). After data quality check and mapping reads to a reference genome, the peaking calling procedure compromises the following steps: 1) reads resampling; 2) reads scaling (normalization) and computing signal-to-noise fold changes; 3) filtering; 4) Calling peaks based on a statistically significant threshold. This is a non-parametric method for peak calling (NPPC). We also used irreproducible discovery rate (IDR) analysis, as well as ChIP-Seq data to compare the peaks called by the NPPC. We identified approximately 6,000 peaks for DSX, which point to 1,225 genes related to the fat body tissue difference between female and male Drosophila. Statistical evidence from IDR analysis indicated that these peaks are reproducible across biological replicates. In addition, these peaks are comparable to those identified by use of ChIP-Seq on S2 cells, in terms of peak number, location, and peaks width.

  13. Parametric pendulum based wave energy converter

    Science.gov (United States)

    Yurchenko, Daniil; Alevras, Panagiotis

    2018-01-01

    The paper investigates the dynamics of a novel wave energy converter based on the parametrically excited pendulum. The herein developed concept of the parametric pendulum allows reducing the influence of the gravity force thereby significantly improving the device performance at a regular sea state, which could not be achieved in the earlier proposed original point-absorber design. The suggested design of a wave energy converter achieves a dominant rotational motion without any additional mechanisms, like a gearbox, or any active control involvement. Presented numerical results of deterministic and stochastic modeling clearly reflect the advantage of the proposed design. A set of experimental results confirms the numerical findings and validates the new design of a parametric pendulum based wave energy converter. Power harvesting potential of the novel device is also presented.

  14. Parametric methods for spatial point processes

    DEFF Research Database (Denmark)

    Møller, Jesper

    is studied in Section 4, and Bayesian inference in Section 5. On one hand, as the development in computer technology and computational statistics continues,computationally-intensive simulation-based methods for likelihood inference probably will play a increasing role for statistical analysis of spatial...... inference procedures for parametric spatial point process models. The widespread use of sensible but ad hoc methods based on summary statistics of the kind studied in Chapter 4.3 have through the last two decades been supplied by likelihood based methods for parametric spatial point process models......(This text is submitted for the volume ‘A Handbook of Spatial Statistics' edited by A.E. Gelfand, P. Diggle, M. Fuentes, and P. Guttorp, to be published by Chapmand and Hall/CRC Press, and planned to appear as Chapter 4.4 with the title ‘Parametric methods'.) 1 Introduction This chapter considers...

  15. Parametric Conversion Using Custom MOS Varactors

    Directory of Open Access Journals (Sweden)

    Iniewski Krzysztof (Kris

    2006-01-01

    Full Text Available The possible role of customized MOS varactors in amplification, mixing, and frequency control of future millimeter wave CMOS RFICs is outlined. First, the parametric conversion concept is revisited and discussed in terms of modern RF communications systems. Second, the modeling, design, and optimization of MOS varactors are reconsidered in the context of their central role in parametric circuits. Third, a balanced varactor structure is proposed for robust oscillator frequency control in the presence of large extrinsic noise expected in tightly integrated wireless communicators. Main points include the proposal of a subharmonic pumping scheme based on the MOS varactor, a nonequilibrium elastance-voltage model, optimal varactor layout suggestions, custom m-CMOS varactor design and measurement, device-level balanced varactor simulations, and parametric circuit evaluation based on measured device characteristics.

  16. Piezoelectric energy harvesting with parametric uncertainty

    International Nuclear Information System (INIS)

    Ali, S F; Friswell, M I; Adhikari, S

    2010-01-01

    The design and analysis of energy harvesting devices is becoming increasing important in recent years. Most of the literature has focused on the deterministic analysis of these systems and the problem of uncertain parameters has received less attention. Energy harvesting devices exhibit parametric uncertainty due to errors in measurement, errors in modelling and variability in the parameters during manufacture. This paper investigates the effect of parametric uncertainty in the mechanical system on the harvested power, and derives approximate explicit formulae for the optimal electrical parameters that maximize the mean harvested power. The maximum of the mean harvested power decreases with increasing uncertainty, and the optimal frequency at which the maximum mean power occurs shifts. The effect of the parameter variance on the optimal electrical time constant and optimal coupling coefficient are reported. Monte Carlo based simulation results are used to further analyse the system under parametric uncertainty

  17. Parametric analysis of ATM solar array.

    Science.gov (United States)

    Singh, B. K.; Adkisson, W. B.

    1973-01-01

    The paper discusses the methods used for the calculation of ATM solar array performance characteristics and provides the parametric analysis of solar panels used in SKYLAB. To predict the solar array performance under conditions other than test conditions, a mathematical model has been developed. Four computer programs have been used to convert the solar simulator test data to the parametric curves. The first performs module summations, the second determines average solar cell characteristics which will cause a mathematical model to generate a curve matching the test data, the third is a polynomial fit program which determines the polynomial equations for the solar cell characteristics versus temperature, and the fourth program uses the polynomial coefficients generated by the polynomial curve fit program to generate the parametric data.

  18. Usefulness of myocardial parametric imaging to evaluate myocardial viability in experimental and in clinical studies.

    Science.gov (United States)

    Korosoglou, G; Hansen, A; Bekeredjian, R; Filusch, A; Hardt, S; Wolf, D; Schellberg, D; Katus, H A; Kuecherer, H

    2006-03-01

    To evaluate whether myocardial parametric imaging (MPI) is superior to visual assessment for the evaluation of myocardial viability. Myocardial contrast echocardiography (MCE) was assessed in 11 pigs before, during, and after left anterior descending coronary artery occlusion and in 32 patients with ischaemic heart disease by using intravenous SonoVue administration. In experimental studies perfusion defect area assessment by MPI was compared with visually guided perfusion defect planimetry. Histological assessment of necrotic tissue was the standard reference. In clinical studies viability was assessed on a segmental level by (1) visual analysis of myocardial opacification; (2) quantitative estimation of myocardial blood flow in regions of interest; and (3) MPI. Functional recovery between three and six months after revascularisation was the standard reference. In experimental studies, compared with visually guided perfusion defect planimetry, planimetric assessment of infarct size by MPI correlated more significantly with histology (r2 = 0.92 versus r2 = 0.56) and had a lower intraobserver variability (4% v 15%, p < 0.05). In clinical studies, MPI had higher specificity (66% v 43%, p < 0.05) than visual MCE and good accuracy (81%) for viability detection. It was less time consuming (3.4 (1.6) v 9.2 (2.4) minutes per image, p < 0.05) than quantitative blood flow estimation by regions of interest and increased the agreement between observers interpreting myocardial perfusion (kappa = 0.87 v kappa = 0.75, p < 0.05). MPI is useful for the evaluation of myocardial viability both in animals and in patients. It is less time consuming than quantification analysis by regions of interest and less observer dependent than visual analysis. Thus, strategies incorporating this technique may be valuable for the evaluation of myocardial viability in clinical routine.

  19. Parametric Landau damping of space charge modes

    Energy Technology Data Exchange (ETDEWEB)

    Macridin, Alexandru [Fermilab; Burov, Alexey [Fermilab; Stern, Eric [Fermilab; Amundson, James [Fermilab; Spentzouris, Panagiotis [Fermilab

    2016-09-23

    Landau damping is the mechanism of plasma and beam stabilization; it arises through energy transfer from collective modes to the incoherent motion of resonant particles. Normally this resonance requires the resonant particle's frequency to match the collective mode frequency. We have identified an important new damping mechanism, parametric Landau damping, which is driven by the modulation of the mode-particle interaction. This opens new possibilities for stability control through manipulation of both particle and mode-particle coupling spectra. We demonstrate the existence of parametric Landau damping in a simulation of transverse coherent modes of bunched accelerator beams with space charge.

  20. Universal parametrization for quark and lepton substructure

    International Nuclear Information System (INIS)

    Akama, Keiichi; Terazawa, Hidezumi.

    1994-01-01

    A universal parametrization for possible quark and lepton substructure is advocated in terms of quark and lepton form factors. It is emphasized that the lower bounds on compositeness scale, Λ c , to be determined experimentally strongly depend on their definitions in composite models. From the recent HERA data, it is estimated to be Λ c > 50 GeV, 0.4 TeV and 10 TeV, depending on the parametrizations with a single-pole form factor, a contact interaction and a logarithmic form factor, respectively. (author)

  1. Parametric number covariance in quantum chaotic spectra.

    Science.gov (United States)

    Vinayak; Kumar, Sandeep; Pandey, Akhilesh

    2016-03-01

    We study spectral parametric correlations in quantum chaotic systems and introduce the number covariance as a measure of such correlations. We derive analytic results for the classical random matrix ensembles using the binary correlation method and obtain compact expressions for the covariance. We illustrate the universality of this measure by presenting the spectral analysis of the quantum kicked rotors for the time-reversal invariant and time-reversal noninvariant cases. A local version of the parametric number variance introduced earlier is also investigated.

  2. Parametric frequency conversion in long Josephson junctions

    International Nuclear Information System (INIS)

    Irie, F.; Ashihara, S.; Yoshida, K.

    1976-01-01

    Current steps at voltages corresponding to the parametric coupling between an applied r.f. field and junction resonant modes have been observed in long Josephson tunnel junctions in the flux-flow state. The observed periodic variations of the step height due to the applied magnetic field are explained quantitatively by a perturbational analysis using Josephson phase equations. The present study demonstrates that the moving vortex array can serve as a coherent pump wave for signal waves propagating in the barrier region, which indicates, as a result, the possibility of traveling-wave parametric devices with long Josephson tunnel junctions. (author)

  3. Fast determination of plasma parameters through function parametrization

    International Nuclear Information System (INIS)

    Braams, B.J.; Jilge, W.; Lackner, K.

    1985-09-01

    The method of function parametrization, developed by H. Wind for fast data evaluation in high energy physics, is demonstrated in the context of controlled fusion research. This method relies on a statistical analysis of a large data base of simulated experiments in order to obtain a functional representation for intrinsic physical parameters of a system in terms of the values of the measurements. Rapid determination of characteristic equilibrium parameters of a tokamak discharge is shown to be a particularly indicated application. The method is employed on the ASDEX experiment to determine the following parameters of the plasma: position of the magnetic axis, geometric center, and current center; minor radius, elongation, and area of the plasma column; a normalized safety factor at the plasma boundary; the Shafranov parameter βsub(p)+lsub(i)/2; the flux difference between the plasma boundary and an external reference value; the position of the lower and upper saddle points, and the intersections of the separatrix with the four divertor plates. The relevant measurements consist of three differential poloidal flux measurements, four poloidal field measurements, the current through the multipole shaping coils, and the total plasma current. Function parametrization supplies a very accurate interpretation of these data, which is now used for online data analysis, and is also sufficiently fast to be suitable for real-time control of the plasma. (orig.)

  4. Parametric biomedical imaging - what defines the quality of quantitative radiological approaches?

    International Nuclear Information System (INIS)

    Glueer, C.C.; Barkmann, R.; Bolte, H.; Heller, M.; Hahn, H.K.; Dicken, V.; Majumdar, S.; Eckstein, F.; Nickelsen, T.N.

    2006-01-01

    Quantitative parametric imaging approaches provide new perspectives for radiological imaging. These include quantitative 2D, 3D, and 4D visualization options along with the parametric depiction of biological tissue properties and tissue function. This allows the interpretation of radiological data from a biochemical, biomechanical, or physiological perspective. Quantification permits the detection of small changes that are not yet visually apparent, thus allowing application in early disease diagnosis and monitoring therapy with enhanced sensitivity. This review outlines the potential of quantitative parametric imaging methods and demonstrates this on the basis of a few exemplary applications. One field of particular interest, the use of these methods for investigational new drug application studies, is presented. Assessment criteria for judging the quality of quantitative imaging approaches are discussed in the context of the potential and the limitations of these methods. While quantitative parametric imaging methods do not replace but rather supplement established visual interpretation methods in radiology, they do open up new perspectives for diagnosis and prognosis and in particular for monitoring disease progression and therapy. (orig.)

  5. Using Parametrics to Facilitate Collaborative Urban Design

    DEFF Research Database (Denmark)

    Steinø, Nicolai; Benbih, Karima; Obeling, Esben

    2013-01-01

    in the context of the urban South which is characterized by high urban growth rates, weak planning systems and modest means. The current state of planning and urban development in Morocco is introduced as a context for discussing collaborative urban design and parametric urban design, and some tentative...

  6. Parametric Architectural Design with Point-clouds

    DEFF Research Database (Denmark)

    Zwierzycki, Mateusz; Evers, Henrik Leander; Tamke, Martin

    2016-01-01

    This paper investigates the efforts and benefits of the implementation of point clouds into architectural design processes and tools. Based on a study on the principal work processes of designers with point clouds the prototypical plugin/library - Volvox - was developed for the parametric modelling...

  7. Global chaos synchronization of coupled parametrically excited ...

    Indian Academy of Sciences (India)

    In this paper, we study the synchronization behaviour of two linearly coupled parametrically excited chaotic pendula. The stability of the synchronized state is examined using Lyapunov stability theory and linear matrix inequality (LMI); and some sufficient criteria for global asymptotic synchronization are derived from which ...

  8. Interdisciplinary parametric design : The XXL experience

    NARCIS (Netherlands)

    Turrin, M.; Sariyildiz, I.S.; Paul, J.C.

    2015-01-01

    Focusing on large span structures for sport buildings, the paper tackles the role of parametric modelling and performance simulations, to enhance the integration between architectural and engineering design. The general approach contrasts post-engineering processes. In post-engineering, technical

  9. The parametrized simulation of electromagnetic showers

    International Nuclear Information System (INIS)

    Peters, S.

    1992-09-01

    The simulation of electromagnetic showers in calorimeters by detailed tracking of all secondary particles is extremely computer time consuming. Without loosing considerably in precision, the use of parametrizations for global shower properties may reduce the computing time by factors of 10 1 to 10 4 , depending on the energy, the degree of parametrization, and the complexity in the material description and the cut off energies in the detailed simulation. To arrive at a high degree of universality, parametrizations of individual electromagnetic showers in homogeneous media are developed, taking the dependence of the shower development on the material into account. In sampling calorimeters, the inhomogeneous material distribution leads to additional effects which can be taken into account by geometry dependent terms in the parametrization of the longitudinal and radial energy density distributions. Comparisons with detailed simulations of homogeneous and sampling calorimeters show very good agreement in the fluctuations, correlations, and signal averages of spatial energy distributions. Verifications of the algorithms for the simulation of the H1 detector are performed using calorimeter test data for different moduls of the H1 liquid argon calorimeter. Special attention has been paid to electron pion separation, which is of great importance for physics analysis. (orig.) [de

  10. Narrow linewidth pulsed optical parametric oscillator

    Indian Academy of Sciences (India)

    Tunable narrow linewidth radiation by optical parametric oscillation has many applications, particularly in spectroscopic investigation. In this paper, different techniques such as injection seeding, use of spectral selecting element like grating, grating and etalon in combination, grazing angle of incidence, entangled cavity ...

  11. Consequences of hadron-nucleus multiplicity parametrization

    International Nuclear Information System (INIS)

    Singh, C.P.; Shyam, M.

    1986-01-01

    Some interesting consequences are analyzed of a new parametrization for the hadron-nucleus multiplicity distributions and they are compared with the experimental data. Further, it is illustrated how the scaling property for the average multiplicity will be modified and it is found that the experimental data support this behaviour. (orig.)

  12. Simple parametrization of nucleon form factors

    International Nuclear Information System (INIS)

    Kelly, J.J.

    2004-01-01

    This Brief Report provides simple parametrizations of the nucleon electromagnetic form factors using functions of Q 2 that are consistent with dimensional scaling at high Q 2 . Good fits require only four parameters each for G Ep , G Mp , and G Mn and only two for G En

  13. Parametric studies of tandem mirror reactors

    International Nuclear Information System (INIS)

    Carlson, G.A.; Boghosian, B.M.; Fink, J.H.; Myall, J.O.; Neef, W.S. Jr.

    1979-01-01

    This report, along with its companion, An Improved Tandem Mirror Reactor, discusses the recent progress and present status of our tandem mirror reactor studies. This report presents the detailed results of parametric studies up to, but not including, the very new ideas involving thermal barriers

  14. Path integral quantization of parametrized field theory

    International Nuclear Information System (INIS)

    Varadarajan, Madhavan

    2004-01-01

    Free scalar field theory on a flat spacetime can be cast into a generally covariant form known as parametrized field theory in which the action is a functional of the scalar field as well as the embedding variables which describe arbitrary, in general curved, foliations of the flat spacetime. We construct the path integral quantization of parametrized field theory in order to analyze issues at the interface of quantum field theory and general covariance in a path integral context. We show that the measure in the Lorentzian path integral is nontrivial and is the analog of the Fradkin-Vilkovisky measure for quantum gravity. We construct Euclidean functional integrals in the generally covariant setting of parametrized field theory using key ideas of Schleich and show that our constructions imply the existence of nonstandard 'Wick rotations' of the standard free scalar field two-point function. We develop a framework to study the problem of time through computations of scalar field two-point functions. We illustrate our ideas through explicit computation for a time independent (1+1)-dimensional foliation. Although the problem of time seems to be absent in this simple example, the general case is still open. We discuss our results in the contexts of the path integral formulation of quantum gravity and the canonical quantization of parametrized field theory

  15. Statistical prediction of parametric roll using FORM

    DEFF Research Database (Denmark)

    Jensen, Jørgen Juncher; Choi, Ju-hyuck; Nielsen, Ulrik Dam

    2017-01-01

    Previous research has shown that the First Order Reliability Method (FORM) can be an efficient method for estimation of outcrossing rates and extreme value statistics for stationary stochastic processes. This is so also for bifurcation type of processes like parametric roll of ships. The present...

  16. Probabilistic Reachability for Parametric Markov Models

    DEFF Research Database (Denmark)

    Hahn, Ernst Moritz; Hermanns, Holger; Zhang, Lijun

    2011-01-01

    Given a parametric Markov model, we consider the problem of computing the rational function expressing the probability of reaching a given set of states. To attack this principal problem, Daws has suggested to first convert the Markov chain into a finite automaton, from which a regular expression...

  17. Non-Parametric Estimation of Correlation Functions

    DEFF Research Database (Denmark)

    Brincker, Rune; Rytter, Anders; Krenk, Steen

    In this paper three methods of non-parametric correlation function estimation are reviewed and evaluated: the direct method, estimation by the Fast Fourier Transform and finally estimation by the Random Decrement technique. The basic ideas of the techniques are reviewed, sources of bias are point...

  18. A parametric reconstruction of the deceleration parameter

    Energy Technology Data Exchange (ETDEWEB)

    Al Mamon, Abdulla [Manipal University, Manipal Centre for Natural Sciences, Manipal (India); Visva-Bharati, Department of Physics, Santiniketan (India); Das, Sudipta [Visva-Bharati, Department of Physics, Santiniketan (India)

    2017-07-15

    The present work is based on a parametric reconstruction of the deceleration parameter q(z) in a model for the spatially flat FRW universe filled with dark energy and non-relativistic matter. In cosmology, the parametric reconstruction technique deals with an attempt to build up a model by choosing some specific evolution scenario for a cosmological parameter and then estimate the values of the parameters with the help of different observational datasets. In this paper, we have proposed a logarithmic parametrization of q(z) to probe the evolution history of the universe. Using the type Ia supernova, baryon acoustic oscillation and the cosmic microwave background datasets, the constraints on the arbitrary model parameters q{sub 0} and q{sub 1} are obtained (within 1σ and 2σ confidence limits) by χ{sup 2}-minimization technique. We have then reconstructed the deceleration parameter, the total EoS parameter ω{sub tot}, the jerk parameter and have compared the reconstructed results of q(z) with other well-known parametrizations of q(z). We have also shown that two model selection criteria (namely, the Akaike information criterion and Bayesian information criterion) provide a clear indication that our reconstructed model is well consistent with other popular models. (orig.)

  19. Parametric Primitives for Hand Gesture Recognition

    DEFF Research Database (Denmark)

    Baby, Sanmohan; Krüger, Volker

    2009-01-01

    Imitation learning is considered to be an effective way of teaching humanoid robots and action recognition is the key step to imitation learning. In this paper  an online algorithm to recognize parametric actions with object context is presented. Objects are key instruments in understanding...

  20. Parametric Transverse Patterns in Broad Aperture Lasers

    DEFF Research Database (Denmark)

    Grigorieva, E.V.; Kashchenko, S.A.; Mosekilde, Erik

    1998-01-01

    Parametrically generated optical patterns are investigated for finite and large-scale transverse aperture lasers. Standing and rotating patterns as well as periodic and chaotic pattern alternations are described in the framework of the amplitude equation formalism. Sensitive dependence...... on the geometrical size of the system is demonstrated even in the case of large-scale systems....

  1. Parametric instabilities in advanced gravitational wave detectors

    International Nuclear Information System (INIS)

    Gras, S; Zhao, C; Blair, D G; Ju, L

    2010-01-01

    As the LIGO interferometric gravitational wave detectors have finished gathering a large observational data set, an intense effort is underway to upgrade these observatories to improve their sensitivity by a factor of ∼10. High circulating power in the arm cavities is required, which leads to the possibility of parametric instability due to three-mode opto-acoustic resonant interactions between the carrier, transverse optical modes and acoustic modes. Here, we present detailed numerical analysis of parametric instability in a configuration that is similar to Advanced LIGO. After examining parametric instability for a single three-mode interaction in detail, we examine instability for the best and worst cases, as determined by the resonance condition of transverse modes in the power and signal recycling cavities. We find that, in the best case, the dual recycling detector is substantially less susceptible to instability than a single cavity, but its susceptibility is dependent on the signal recycling cavity design, and on tuning for narrow band operation. In all cases considered, the interferometer will experience parametric instability at full power operation, but the gain varies from 3 to 1000, and the number of unstable modes varies between 7 and 30 per test mass. The analysis focuses on understanding the detector complexity in relation to opto-acoustic interactions, on providing insights that can enable predictions of the detector response to transient disturbances, and of variations in thermal compensation conditions.

  2. Reference Japanese man

    International Nuclear Information System (INIS)

    Tanaka, Giichiro

    1985-01-01

    To make real and accurate dose assessment method so far, it is necessitated to provide ''Reference Japanese Man'' based on anotomical, physiological and biochemical data of Japanese people instead of the Reference Man presented in ICRP Publications 23 and 30. This review describes present status of researched for the purpose of establishing of Reference Japanese Man. The Reference Japanese Man is defined as a male or female adult who lives in Japan with a Japanese life-style and food custom. His stature and body weight, and the other data was decided as mean values of male or female people of Japan. As for food custom, Japanese people take significantly smaller amount of meat and milk products than Western people, while larger intake amount of cereals and marine products such as fish or seaweeds. Weight of organs is a principal factor for internal dose assessment and mean values for living Japanese adult has been investigated and the value employable for dose assessment for organs and tissues are shown. To employ these values of Reference Japanese Man, it should be taken into account of age. Metabolic parameters should also be considered. Iodine metabolism in Japanese is quite different from that of Western people. The above-mentioned data are now tentatively employing in modification of table of MIRD method and others. (Takagi, S.)

  3. Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility.

    Science.gov (United States)

    Edison, Paul; Brooks, David J; Turkheimer, Federico E; Archer, Hilary A; Hinz, Rainer

    2009-11-01

    Pittsburgh compound B or [11C]PIB is an amyloid imaging agent which shows a clear differentiation between subjects with Alzheimer's disease (AD) and controls. However the observed signal difference in other forms of dementia such as dementia with Lewy bodies (DLB) is smaller, and mild cognitively impaired (MCI) subjects and some healthy elderly normals may show intermediate levels of [11C]PIB binding. The cerebellum, a commonly used reference region for non-specific tracer uptake in [11C]PIB studies in AD may not be valid in Prion disorders or monogenic forms of AD. The aim of this work was to: 1-compare methods for generating parametric maps of [11C]PIB retention in tissue using a plasma input function in respect of their ability to discriminate between AD subjects and controls and 2-estimate the test-retest reproducibility in AD subjects. 12 AD subjects (5 of which underwent a repeat scan within 6 weeks) and 10 control subjects had 90 minute [11C]PIB dynamic PET scans, and arterial plasma input functions were measured. Parametric maps were generated with graphical analysis of reversible binding (Logan plot), irreversible binding (Patlak plot), and spectral analysis. Between group differentiation was calculated using Student's t-test and comparisons between different methods were made using p values. Reproducibility was assessed by intraclass correlation coefficients (ICC). We found that the 75 min value of the impulse response function showed the best group differentiation and had a higher ICC than volume of distribution maps generated from Logan and spectral analysis. Patlak analysis of [11C]PIB binding was the least reproducible.

  4. TU-AB-BRC-03: Accurate Tissue Characterization for Monte Carlo Dose Calculation Using Dual-and Multi-Energy CT Data

    Energy Technology Data Exchange (ETDEWEB)

    Lalonde, A; Bouchard, H [University of Montreal, Montreal, Qc (Canada)

    2016-06-15

    Purpose: To develop a general method for human tissue characterization with dual-and multi-energy CT and evaluate its performance in determining elemental compositions and the associated proton stopping power relative to water (SPR) and photon mass absorption coefficients (EAC). Methods: Principal component analysis is used to extract an optimal basis of virtual materials from a reference dataset of tissues. These principal components (PC) are used to perform two-material decomposition using simulated DECT data. The elemental mass fraction and the electron density in each tissue is retrieved by measuring the fraction of each PC. A stoichiometric calibration method is adapted to the technique to make it suitable for clinical use. The present approach is compared with two others: parametrization and three-material decomposition using the water-lipid-protein (WLP) triplet. Results: Monte Carlo simulations using TOPAS for four reference tissues shows that characterizing them with only two PC is enough to get a submillimetric precision on proton range prediction. Based on the simulated DECT data of 43 references tissues, the proposed method is in agreement with theoretical values of protons SPR and low-kV EAC with a RMS error of 0.11% and 0.35%, respectively. In comparison, parametrization and WLP respectively yield RMS errors of 0.13% and 0.29% on SPR, and 2.72% and 2.19% on EAC. Furthermore, the proposed approach shows potential applications for spectral CT. Using five PC and five energy bins reduces the SPR RMS error to 0.03%. Conclusion: The proposed method shows good performance in determining elemental compositions from DECT data and physical quantities relevant to radiotherapy dose calculation and generally shows better accuracy and unbiased results compared to reference methods. The proposed method is particularly suitable for Monte Carlo calculations and shows promise in using more than two energies to characterize human tissue with CT.

  5. TU-AB-BRC-03: Accurate Tissue Characterization for Monte Carlo Dose Calculation Using Dual-and Multi-Energy CT Data

    International Nuclear Information System (INIS)

    Lalonde, A; Bouchard, H

    2016-01-01

    Purpose: To develop a general method for human tissue characterization with dual-and multi-energy CT and evaluate its performance in determining elemental compositions and the associated proton stopping power relative to water (SPR) and photon mass absorption coefficients (EAC). Methods: Principal component analysis is used to extract an optimal basis of virtual materials from a reference dataset of tissues. These principal components (PC) are used to perform two-material decomposition using simulated DECT data. The elemental mass fraction and the electron density in each tissue is retrieved by measuring the fraction of each PC. A stoichiometric calibration method is adapted to the technique to make it suitable for clinical use. The present approach is compared with two others: parametrization and three-material decomposition using the water-lipid-protein (WLP) triplet. Results: Monte Carlo simulations using TOPAS for four reference tissues shows that characterizing them with only two PC is enough to get a submillimetric precision on proton range prediction. Based on the simulated DECT data of 43 references tissues, the proposed method is in agreement with theoretical values of protons SPR and low-kV EAC with a RMS error of 0.11% and 0.35%, respectively. In comparison, parametrization and WLP respectively yield RMS errors of 0.13% and 0.29% on SPR, and 2.72% and 2.19% on EAC. Furthermore, the proposed approach shows potential applications for spectral CT. Using five PC and five energy bins reduces the SPR RMS error to 0.03%. Conclusion: The proposed method shows good performance in determining elemental compositions from DECT data and physical quantities relevant to radiotherapy dose calculation and generally shows better accuracy and unbiased results compared to reference methods. The proposed method is particularly suitable for Monte Carlo calculations and shows promise in using more than two energies to characterize human tissue with CT.

  6. Parametric instabilities in magnetized bi-ion and dusty plasmas

    Indian Academy of Sciences (India)

    -ion or dusty plasma with parametric pumping of the magnetic field is analysed. The equation of motion governing the perturbed plasma is derived and parametrically excited transverse modes propagating along the magnetic field are found.

  7. Pump to signal noise transfer in parametric fiber amplifiers

    DEFF Research Database (Denmark)

    Lund-Hansen, Toke; Rottwitt, Karsten; Peucheret, Christophe

    2010-01-01

    Fiber optic parametric amplifiers have been suggested due to their potential low spontaneous emission. However, by nature the parametric amplifier only work in a forward pumped configuration, which result in transfer of relative intensity noise in the pump to the signal.......Fiber optic parametric amplifiers have been suggested due to their potential low spontaneous emission. However, by nature the parametric amplifier only work in a forward pumped configuration, which result in transfer of relative intensity noise in the pump to the signal....

  8. Hyperbolic and semi-parametric models in finance

    Science.gov (United States)

    Bingham, N. H.; Kiesel, Rüdiger

    2001-02-01

    The benchmark Black-Scholes-Merton model of mathematical finance is parametric, based on the normal/Gaussian distribution. Its principal parametric competitor, the hyperbolic model of Barndorff-Nielsen, Eberlein and others, is briefly discussed. Our main theme is the use of semi-parametric models, incorporating the mean vector and covariance matrix as in the Markowitz approach, plus a non-parametric part, a scalar function incorporating features such as tail-decay. Implementation is also briefly discussed.

  9. Fault detection and isolation in systems with parametric faults

    DEFF Research Database (Denmark)

    Stoustrup, Jakob; Niemann, Hans Henrik

    1999-01-01

    The problem of fault detection and isolation of parametric faults is considered in this paper. A fault detection problem based on parametric faults are associated with internal parameter variations in the dynamical system. A fault detection and isolation method for parametric faults is formulated...

  10. Parametric Audio Based Decoder and Music Synthesizer for Mobile Applications

    NARCIS (Netherlands)

    Oomen, A.W.J.; Szczerba, M.Z.; Therssen, D.

    2011-01-01

    This paper reviews parametric audio coders and discusses novel technologies introduced in a low-complexity, low-power consumption audiodecoder and music synthesizer platform developed by the authors. Thedecoder uses parametric coding scheme based on the MPEG-4 Parametric Audio standard. In order to

  11. Parametric Study Of Window Frame Geometry

    DEFF Research Database (Denmark)

    Zajas, Jan Jakub; Heiselberg, Per

    2013-01-01

    This paper describes a parametric study on window frame geometry with the goal of designing frames with very good thermal properties. Three different parametric frame models are introduced, deseribed by a number of variables. In the first part of the study, a process of sensitivity analysis...... is conducted to determine which of the parameters describing the frame have the highest impact on its thermal performance. Afterwards, an optimization process is conducted on each frame in order to optimize the design with regard to three objectives: minimizing the thermal transmittance, maxim izing the net...... energy gain factor and minimizing the material use. Since the objectives contradiet each other, it was found that it is not possible to identifY a single solution that satisfies all these goals. lnstead, a compromise between the objectives has to be found....

  12. Parametric structural modeling of insect wings

    International Nuclear Information System (INIS)

    Mengesha, T E; Vallance, R R; Barraja, M; Mittal, R

    2009-01-01

    Insects produce thrust and lift forces via coupled fluid-structure interactions that bend and twist their compliant wings during flapping cycles. Insight into this fluid-structure interaction is achieved with numerical modeling techniques such as coupled finite element analysis and computational fluid dynamics, but these methods require accurate and validated structural models of insect wings. Structural models of insect wings depend principally on the shape, dimensions and material properties of the veins and membrane cells. This paper describes a method for parametric modeling of wing geometry using digital images and demonstrates the use of the geometric models in constructing three-dimensional finite element (FE) models and simple reduced-order models. The FE models are more complete and accurate than previously reported models since they accurately represent the topology of the vein network, as well as the shape and dimensions of the veins and membrane cells. The methods are demonstrated by developing a parametric structural model of a cicada forewing.

  13. Casas-Ibarra parametrization and leptogenesis

    International Nuclear Information System (INIS)

    Xing Zhizhong

    2010-01-01

    The Casas-Ibarra parametrization is a description of the Dirac neutrino mass matrix M D in terms of the neutrino mixing matrix V, an orthogonal matrix O and the diagonal mass matrices of light and heavy Majorana neutrinos in the type-I seesaw mechanism. Because M D + M D is apparently independent of V but dependent on O in this parametrization, a number of authors have claimed that unflavored leptogenesis has nothing to do with CP violation at low energies. Here we question this logic by clarifying the physical meaning of O. We establish a clear relationship between O and the observable quantities, and find that O does depend on V. We show that both unflavored leptogenesis and flavored leptogenesis have no direct connection with low-energy CP violation. (authors)

  14. Rayleigh-type parametric chemical oscillation

    Energy Technology Data Exchange (ETDEWEB)

    Ghosh, Shyamolina; Ray, Deb Shankar, E-mail: pcdsr@iacs.res.in [Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032 (India)

    2015-09-28

    We consider a nonlinear chemical dynamical system of two phase space variables in a stable steady state. When the system is driven by a time-dependent sinusoidal forcing of a suitable scaling parameter at a frequency twice the output frequency and the strength of perturbation exceeds a threshold, the system undergoes sustained Rayleigh-type periodic oscillation, wellknown for parametric oscillation in pipe organs and distinct from the usual forced quasiperiodic oscillation of a damped nonlinear system where the system is oscillatory even in absence of any external forcing. Our theoretical analysis of the parametric chemical oscillation is corroborated by full numerical simulation of two well known models of chemical dynamics, chlorite-iodine-malonic acid and iodine-clock reactions.

  15. Rayleigh-type parametric chemical oscillation.

    Science.gov (United States)

    Ghosh, Shyamolina; Ray, Deb Shankar

    2015-09-28

    We consider a nonlinear chemical dynamical system of two phase space variables in a stable steady state. When the system is driven by a time-dependent sinusoidal forcing of a suitable scaling parameter at a frequency twice the output frequency and the strength of perturbation exceeds a threshold, the system undergoes sustained Rayleigh-type periodic oscillation, wellknown for parametric oscillation in pipe organs and distinct from the usual forced quasiperiodic oscillation of a damped nonlinear system where the system is oscillatory even in absence of any external forcing. Our theoretical analysis of the parametric chemical oscillation is corroborated by full numerical simulation of two well known models of chemical dynamics, chlorite-iodine-malonic acid and iodine-clock reactions.

  16. Parametric instability in GEO 600 interferometer

    International Nuclear Information System (INIS)

    Gurkovsky, A.G.; Vyatchanin, S.P.

    2007-01-01

    We present analysis of undesirable effect of parametric instability in signal recycled GEO 600 interferometer. The basis for this effect is provided by excitation of additional (Stokes) optical mode, having frequency ω 1 , and mirror elastic mode, having frequency ω m , when the optical energy stored in the main FP cavity mode, having frequency ω 0 , exceeds a certain threshold and detuning Δ=ω 0 -ω 1 -ω m is small. We discuss the potential of observing parametric instability and its precursors in GEO 600 interferometer. This approach provides the best option to get familiar with this phenomenon, to develop experimental methods to depress it and to test the effectiveness of these methods in situ

  17. Parametric Immunization in Bond Portfolio Management

    OpenAIRE

    Bravo, Jorge; Fonseca, José

    2012-01-01

    In this paper, we evaluate the relative immunization performance of the multifactor parametric interest rate risk model based on the Nelson-Siegel-Svensson specification of the yield curve with that of standard benchmark investment strategies, using European Central Bank yield curve data in the period between January 3, 2005 and December 31, 2011. In addition, we examine the role of portfolio design in the success of immunization strategies, particularly the role of the maturit...

  18. Parametric study of laser photovoltaic energy converters

    Science.gov (United States)

    Walker, G. H.; Heinbockel, J. H.

    1987-01-01

    Photovoltaic converters are of interest for converting laser power to electrical power in a space-based laser power system. This paper describes a model for photovoltaic laser converters and the application of this model to a neodymium laser silicon photovoltaic converter system. A parametric study which defines the sensitivity of the photovoltaic parameters is described. An optimized silicon photovoltaic converter has an efficiency greater than 50 percent for 1000 W/sq cm of neodymium laser radiation.

  19. Acoustic parametric pumping of spin waves

    Science.gov (United States)

    Keshtgar, Hedyeh; Zareyan, Malek; Bauer, Gerrit E. W.

    2014-11-01

    Recent experiments demonstrated generation of spin currents by ultrasound. We can understand this acoustically induced spin pumping in terms of the coupling between magnetization and lattice waves. Here we study the parametric excitation of magnetization by longitudinal acoustic waves and calculate the acoustic threshold power. The induced magnetization dynamics can be detected by the spin pumping into an adjacent normal metal that displays the inverse spin Hall effect.

  20. Acoustic parametric pumping of spin waves

    OpenAIRE

    Keshtgar, Hedyeh; Zareyan, Malek; Bauer, Gerrit E. W.

    2013-01-01

    Recent experiments demonstrated generation of spin currents by ultrasound. We can understand this acoustically induced spin pumping in terms of the coupling between magnetization and lattice waves. Here we study the parametric excitation of magnetization by longitudinal acoustic waves and calculate the acoustic threshold power. The induced magnetization dynamics can be detected by the spin pumping into an adjacent normal metal that displays the inverse spin Hall effect.

  1. Parametric motivation bases of floranimic nomination

    Directory of Open Access Journals (Sweden)

    Olga P. Ryabko

    2016-09-01

    Full Text Available The period of further development in the cognitive theory of nomination has been extensive in recent years. Our research has been concentrated on the formation of conceptual foundations in cognitive theory of flora nomination. The macrofield of flora namings embraces three microfields: parametric, pragmatic and locative-temporal ones. They determine motivation processes in cognitive theory of flora nomination, i.e., the presentation of systematic qualities in flora namings in the English language. The description and characterization of such qualities presupposes the existence of their taxonomic organization and methodology criteria, both general and practical ones. Flora namings on the phenomenological level are considered to be the products of naöve-cognitive consciousness of language speakers. They are determined, from the one hand, by the external perceptive adaptations (parametric nomination and, from the other hand, by practical needs (pure pragmatic nomination and local-temporal nomination. In this article we have concentrated on the complex parametric motivated basis of flora nomination. It is presented by a number of qualities, firstly, by dominative qualities («form», «appearance and manner of growth», «color», secondly, by peripheral qualities («odour», «taste», «size» and, finally, by minor qualities («sound», «weight», «genger». In the structure of complex parametric nomination the only one conerete qualitative element from the whole combination of qualities becomes the leading one. The cultural-archetypal dominant element determines. In each concrete situation, the choice of preferable prototypal motivated quality.

  2. Multidimensional Scaling Visualization using Parametric Similarity Indices

    OpenAIRE

    Machado, J. A. Tenreiro; Lopes, António M.; Galhano, A.M.

    2015-01-01

    In this paper, we apply multidimensional scaling (MDS) and parametric similarity indices (PSI) in the analysis of complex systems (CS). Each CS is viewed as a dynamical system, exhibiting an output time-series to be interpreted as a manifestation of its behavior. We start by adopting a sliding window to sample the original data into several consecutive time periods. Second, we define a given PSI for tracking pieces of data. We then compare the windows for different values of the parameter, an...

  3. On Algebraic Approach for MSD Parametric Estimation

    OpenAIRE

    Oueslati , Marouene; Thiery , Stéphane; Gibaru , Olivier; Béarée , Richard; Moraru , George

    2011-01-01

    This article address the identification problem of the natural frequency and the damping ratio of a second order continuous system where the input is a sinusoidal signal. An algebra based approach for identifying parameters of a Mass Spring Damper (MSD) system is proposed and compared to the Kalman-Bucy filter. The proposed estimator uses the algebraic parametric method in the frequency domain yielding exact formula, when placed in the time domain to identify the unknown parameters. We focus ...

  4. Supercritical nonlinear parametric dynamics of Timoshenko microbeams

    Science.gov (United States)

    Farokhi, Hamed; Ghayesh, Mergen H.

    2018-06-01

    The nonlinear supercritical parametric dynamics of a Timoshenko microbeam subject to an axial harmonic excitation force is examined theoretically, by means of different numerical techniques, and employing a high-dimensional analysis. The time-variant axial load is assumed to consist of a mean value along with harmonic fluctuations. In terms of modelling, a continuous expression for the elastic potential energy of the system is developed based on the modified couple stress theory, taking into account small-size effects; the kinetic energy of the system is also modelled as a continuous function of the displacement field. Hamilton's principle is employed to balance the energies and to obtain the continuous model of the system. Employing the Galerkin scheme along with an assumed-mode technique, the energy terms are reduced, yielding a second-order reduced-order model with finite number of degrees of freedom. A transformation is carried out to convert the second-order reduced-order model into a double-dimensional first order one. A bifurcation analysis is performed for the system in the absence of the axial load fluctuations. Moreover, a mean value for the axial load is selected in the supercritical range, and the principal parametric resonant response, due to the time-variant component of the axial load, is obtained - as opposed to transversely excited systems, for parametrically excited system (such as our problem here), the nonlinear resonance occurs in the vicinity of twice any natural frequency of the linear system; this is accomplished via use of the pseudo-arclength continuation technique, a direct time integration, an eigenvalue analysis, and the Floquet theory for stability. The natural frequencies of the system prior to and beyond buckling are also determined. Moreover, the effect of different system parameters on the nonlinear supercritical parametric dynamics of the system is analysed, with special consideration to the effect of the length-scale parameter.

  5. Scaled parametric equation of state for steam in the critical region

    International Nuclear Information System (INIS)

    Murphy, T.A.; Sengers, J.V.

    1975-01-01

    The anomalous thermodynamic behavior of fluids near the critical point can be described in terms of scaling laws. In recent years a parametric equation of state, the so-called Linear Model, has been proposed that satisfies the scaling laws and contains only a small number of adjustable parameters. It is shown that the Linear Model yields a satisfactory representation of the experimental P-V-T data for steam in the critical region. (29 references)

  6. Quantum theory of novel parametric devices

    International Nuclear Information System (INIS)

    Drummond, P.D.; Reid, M.D.; Dechoum, K.; Chaturvedi, S.; Olsen, M.; Kheruntsyan, K.; Bradley, A.

    2005-01-01

    While the parametric amplifier is a widely used and important source of entangled and squeezed photons, there are many possible ways to investigate the physics of intracavity parametric devices. Novel quantum theory of parametric devices in this talk will cover several new types of unconventional devices, including the following topics:- Critical intracavity paramp - We calculate intrinsic limits to entanglement of a quantum paramp, caused by nonlinear effects originating in phase noise of the pump. - Degenerate planar paramp - We obtain universal quantum critical fluctuations in a planar paramp device by mapping to the equations of magnetic Lifshitz points Nondegenerate planar paramp - The Mermin-Wagner theorem is used to demonstrate that there is no phase transition in the case of a nondegenerate planar device - Coupled channel paramp - A robust and novel integrated entanglement source can be generated using type I waveguides coupled inside a cavity to generate spatial entanglement - Cascade paramps - This possible 'GHZ-type' source is obtained by cascading successive down conversion crystals inside the same cavity, giving two thresholds Parallel paramps - Tripartite entanglement can be generated if three intracavity paramp crystals are operated in parallel, each idler mode acting as a signal for the next. Finally, we briefly treat the relevant experimental developments. (author)

  7. Sgr A* Emission Parametrizations from GRMHD Simulations

    Science.gov (United States)

    Anantua, Richard; Ressler, Sean; Quataert, Eliot

    2018-06-01

    Galactic Center emission near the vicinity of the central black hole, Sagittarius (Sgr) A*, is modeled using parametrizations involving the electron temperature, which is found from general relativistic magnetohydrodynamic (GRMHD) simulations to be highest in the disk-outflow corona. Jet-motivated prescriptions generalizing equipartition of particle and magnetic energies, e.g., by scaling relativistic electron energy density to powers of the magnetic field strength, are also introduced. GRMHD jet (or outflow)/accretion disk/black hole (JAB) simulation postprocessing codes IBOTHROS and GRMONTY are employed in the calculation of images and spectra. Various parametric models reproduce spectral and morphological features, such as the sub-mm spectral bump in electron temperature models and asymmetric photon rings in equipartition-based models. The Event Horizon Telescope (EHT) will provide unprecedentedly high-resolution 230+ GHz observations of the "shadow" around Sgr A*'s supermassive black hole, which the synthetic models presented here will reverse-engineer. Both electron temperature and equipartition-based models can be constructed to be compatible with EHT size constraints for the emitting region of Sgr A*. This program sets the groundwork for devising a unified emission parametrization flexible enough to model disk, corona and outflow/jet regions with a small set of parameters including electron heating fraction and plasma beta.

  8. Parametric Cost Models for Space Telescopes

    Science.gov (United States)

    Stahl, H. Philip; Henrichs, Todd; Dollinger, Courtney

    2010-01-01

    Multivariable parametric cost models for space telescopes provide several benefits to designers and space system project managers. They identify major architectural cost drivers and allow high-level design trades. They enable cost-benefit analysis for technology development investment. And, they provide a basis for estimating total project cost. A survey of historical models found that there is no definitive space telescope cost model. In fact, published models vary greatly [1]. Thus, there is a need for parametric space telescopes cost models. An effort is underway to develop single variable [2] and multi-variable [3] parametric space telescope cost models based on the latest available data and applying rigorous analytical techniques. Specific cost estimating relationships (CERs) have been developed which show that aperture diameter is the primary cost driver for large space telescopes; technology development as a function of time reduces cost at the rate of 50% per 17 years; it costs less per square meter of collecting aperture to build a large telescope than a small telescope; and increasing mass reduces cost.

  9. Parametric cost models for space telescopes

    Science.gov (United States)

    Stahl, H. Philip; Henrichs, Todd; Dollinger, Courtnay

    2017-11-01

    Multivariable parametric cost models for space telescopes provide several benefits to designers and space system project managers. They identify major architectural cost drivers and allow high-level design trades. They enable cost-benefit analysis for technology development investment. And, they provide a basis for estimating total project cost. A survey of historical models found that there is no definitive space telescope cost model. In fact, published models vary greatly [1]. Thus, there is a need for parametric space telescopes cost models. An effort is underway to develop single variable [2] and multi-variable [3] parametric space telescope cost models based on the latest available data and applying rigorous analytical techniques. Specific cost estimating relationships (CERs) have been developed which show that aperture diameter is the primary cost driver for large space telescopes; technology development as a function of time reduces cost at the rate of 50% per 17 years; it costs less per square meter of collecting aperture to build a large telescope than a small telescope; and increasing mass reduces cost.

  10. Nonscaling parametrization of hadronic spectra and dual parton model

    International Nuclear Information System (INIS)

    Gaponenko, O.N.

    2001-01-01

    Using the popular Wdowczyk-Wolfendale parametrization (WW-parametrization) as an example one studies restrictions imposed by a dual parton model for different nonscaling parametrizations of the pulsed hadron spectra in soft hadron-hadron and hadron-nuclear interactions. One derived a new parametrization free from basic drawback of the WW-formulae. In the central range the determined parametrization show agreement with the Wdowczyk-Wolfendale formula, but in contrast to the last-named one it does not result in contradiction with the experiment due to fast reduction of inelastic factor reduction with energy increase [ru

  11. Unified triminimal parametrizations of quark and lepton mixing matrices

    International Nuclear Information System (INIS)

    He Xiaogang; Li Shiwen; Ma Boqiang

    2009-01-01

    We present a detailed study on triminimal parametrizations of quark and lepton mixing matrices with different basis matrices. We start with a general discussion on the triminimal expansion of the mixing matrix and on possible unified quark and lepton parametrization using quark-lepton complementarity. We then consider several interesting basis matrices and compare the triminimal parametrizations with the Wolfenstein-like parametrizations. The usual Wolfenstein parametrization for quark mixing is a triminimal expansion around the unit matrix as the basis. The corresponding quark-lepton complementarity lepton mixing matrix is a triminimal expansion around the bimaximal basis. Current neutrino oscillation data show that the lepton mixing matrix is very well represented by the tribimaximal mixing. It is natural to take it as an expanding basis. The corresponding zeroth order basis for quark mixing in this case makes the triminimal expansion converge much faster than the usual Wolfenstein parametrization. The triminimal expansion based on tribimaximal mixing can be converted to the Wolfenstein-like parametrizations discussed in the literature. We thus have a unified description between different kinds of parametrizations for quark and lepton sectors: the standard parametrizations, the Wolfenstein-like parametrizations, and the triminimal parametrizations.

  12. Parametric resonance of intrinsic localized modes in coupled cantilever arrays

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, Masayuki, E-mail: kimura.masayuki.8c@kyoto-u.ac.jp [Department of Electrical Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510 (Japan); Matsushita, Yasuo [Advanced Mathematical Institute, Osaka City University, 3-3-138 Sughimoto, Sumiyoshi-ku, Osaka 558-8585 (Japan); Hikihara, Takashi [Department of Electrical Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510 (Japan)

    2016-08-19

    In this study, the parametric resonances of pinned intrinsic localized modes (ILMs) were investigated by computing the unstable regions in parameter space consisting of parametric excitation amplitude and frequency. In the unstable regions, the pinned ILMs were observed to lose stability and begin to fluctuate. A nonlinear Klein–Gordon, Fermi–Pasta–Ulam-like, and mixed lattices were investigated. The pinned ILMs, particularly in the mixed lattice, were destabilized by parametric resonances, which were determined by comparing the shapes of the unstable regions with those in the Mathieu differential equation. In addition, traveling ILMs could be generated by parametric excitation. - Highlights: • Destabilization of intrinsic localized modes (ILMs) by parametric excitation is investigated for FPU, NKG, and mixed lattices. • Frequency and amplitude of parametric excitation is determined based on characteristic multipliers of ILMs. • Unstable regions for the mixed lattice case show very similar shape to those of the Mathieu equation. • ILMs become unstable by causing parametric resonance.

  13. Parametric resonance of intrinsic localized modes in coupled cantilever arrays

    International Nuclear Information System (INIS)

    Kimura, Masayuki; Matsushita, Yasuo; Hikihara, Takashi

    2016-01-01

    In this study, the parametric resonances of pinned intrinsic localized modes (ILMs) were investigated by computing the unstable regions in parameter space consisting of parametric excitation amplitude and frequency. In the unstable regions, the pinned ILMs were observed to lose stability and begin to fluctuate. A nonlinear Klein–Gordon, Fermi–Pasta–Ulam-like, and mixed lattices were investigated. The pinned ILMs, particularly in the mixed lattice, were destabilized by parametric resonances, which were determined by comparing the shapes of the unstable regions with those in the Mathieu differential equation. In addition, traveling ILMs could be generated by parametric excitation. - Highlights: • Destabilization of intrinsic localized modes (ILMs) by parametric excitation is investigated for FPU, NKG, and mixed lattices. • Frequency and amplitude of parametric excitation is determined based on characteristic multipliers of ILMs. • Unstable regions for the mixed lattice case show very similar shape to those of the Mathieu equation. • ILMs become unstable by causing parametric resonance.

  14. A probabilistic strategy for parametric catastrophe insurance

    Science.gov (United States)

    Figueiredo, Rui; Martina, Mario; Stephenson, David; Youngman, Benjamin

    2017-04-01

    Economic losses due to natural hazards have shown an upward trend since 1980, which is expected to continue. Recent years have seen a growing worldwide commitment towards the reduction of disaster losses. This requires effective management of disaster risk at all levels, a part of which involves reducing financial vulnerability to disasters ex-ante, ensuring that necessary resources will be available following such events. One way to achieve this is through risk transfer instruments. These can be based on different types of triggers, which determine the conditions under which payouts are made after an event. This study focuses on parametric triggers, where payouts are determined by the occurrence of an event exceeding specified physical parameters at a given location, or at multiple locations, or over a region. This type of product offers a number of important advantages, and its adoption is increasing. The main drawback of parametric triggers is their susceptibility to basis risk, which arises when there is a mismatch between triggered payouts and the occurrence of loss events. This is unavoidable in said programmes, as their calibration is based on models containing a number of different sources of uncertainty. Thus, a deterministic definition of the loss event triggering parameters appears flawed. However, often for simplicity, this is the way in which most parametric models tend to be developed. This study therefore presents an innovative probabilistic strategy for parametric catastrophe insurance. It is advantageous as it recognizes uncertainties and minimizes basis risk while maintaining a simple and transparent procedure. A logistic regression model is constructed here to represent the occurrence of loss events based on certain loss index variables, obtained through the transformation of input environmental variables. Flood-related losses due to rainfall are studied. The resulting model is able, for any given day, to issue probabilities of occurrence of loss

  15. [Technical background of data collection for parametric observation of total mesorectal excision (TME) in rectal cancer].

    Science.gov (United States)

    Bláha, M; Hoch, J; Ferko, A; Ryška, A; Hovorková, E

    Improvement in any human activity is preconditioned by inspection of results and providing feedback used for modification of the processes applied. Comparison of experts experience in the given field is another indispensable part leading to optimisation and improvement of processes, and optimally to implementation of standards. For the purpose of objective comparison and assessment of the processes, it is always necessary to describe the processes in a parametric way, to obtain representative data, to assess the achieved results, and to provide unquestionable and data-driven feedback based on such analysis. This may lead to a consensus on the definition of standards in the given area of health care. Total mesorectal excision (TME) is a standard procedure of rectal cancer (C20) surgical treatment. However, the quality of performed procedures varies in different health care facilities, which is given, among others, by internal processes and surgeons experience. Assessment of surgical treatment results is therefore of key importance. A pathologist who assesses the resected tissue can provide valuable feedback in this respect. An information system for the parametric assessment of TME performance is described in our article, including technical background in the form of a multicentre clinical registry and the structure of observed parameters. We consider the proposed system of TME parametric assessment as significant for improvement of TME performance, aimed at reducing local recurrences and at improving the overall prognosis of patients. rectal cancer total mesorectal excision parametric data clinical registries TME registry.

  16. Direct Parametric Reconstruction With Joint Motion Estimation/Correction for Dynamic Brain PET Data.

    Science.gov (United States)

    Jiao, Jieqing; Bousse, Alexandre; Thielemans, Kris; Burgos, Ninon; Weston, Philip S J; Schott, Jonathan M; Atkinson, David; Arridge, Simon R; Hutton, Brian F; Markiewicz, Pawel; Ourselin, Sebastien

    2017-01-01

    Direct reconstruction of parametric images from raw photon counts has been shown to improve the quantitative analysis of dynamic positron emission tomography (PET) data. However it suffers from subject motion which is inevitable during the typical acquisition time of 1-2 hours. In this work we propose a framework to jointly estimate subject head motion and reconstruct the motion-corrected parametric images directly from raw PET data, so that the effects of distorted tissue-to-voxel mapping due to subject motion can be reduced in reconstructing the parametric images with motion-compensated attenuation correction and spatially aligned temporal PET data. The proposed approach is formulated within the maximum likelihood framework, and efficient solutions are derived for estimating subject motion and kinetic parameters from raw PET photon count data. Results from evaluations on simulated [ 11 C]raclopride data using the Zubal brain phantom and real clinical [ 18 F]florbetapir data of a patient with Alzheimer's disease show that the proposed joint direct parametric reconstruction motion correction approach can improve the accuracy of quantifying dynamic PET data with large subject motion.

  17. Japanese reference man 1988, 3

    International Nuclear Information System (INIS)

    Tanaka, Gi-ichiro

    1988-01-01

    Quantitative description of physical properties and other characteristics of the human body is one of the basic data for estimating dose equivalent and calculating Annual Limit on Intake of radionuclides. The exact mass weight of organs and tissues are measured from about 1000 autopsy cases of normal Japanese adults and physical properties are obtained from recent Japanese Government publications. Japanese (Asian) Reference Man is completed by establishing the Normal Japanese, harmonizing with Caucasian Reference Man and coinciding with the ICRP Reference Man Task Group members concept. (author)

  18. Consistency of parametric registration in serial MRI studies of brain tumor progression

    International Nuclear Information System (INIS)

    Mang, Andreas; Buzug, Thorsten M.; Schnabel, Julia A.; Crum, William R.; Modat, Marc; Ourselin, Sebastien; Hawkes, David J.; Camara-Rey, Oscar; Palm, Christoph; Caseiras, Gisele Brasil; Jaeger, H.R.

    2008-01-01

    The consistency of parametric registration in multi-temporal magnetic resonance (MR) imaging studies was evaluated. Serial MRI scans of adult patients with a brain tumor (glioma) were aligned by parametric registration. The performance of low-order spatial alignment (6/9/12 degrees of freedom) of different 3D serial MR-weighted images is evaluated. A registration protocol for the alignment of all images to one reference coordinate system at baseline is presented. Registration results were evaluated for both, multimodal intra-timepoint and mono-modal multi-temporal registration. The latter case might present a challenge to automatic intensity-based registration algorithms due to ill-defined correspondences. The performance of our algorithm was assessed by testing the inverse registration consistency. Four different similarity measures were evaluated to assess consistency. Careful visual inspection suggests that images are well aligned, but their consistency may be imperfect. Sub-voxel inconsistency within the brain was found for allsimilarity measures used for parametric multi-temporal registration. T1-weighted images were most reliable for establishing spatial correspondence between different timepoints. The parametric registration algorithm is feasible for use in this application. The sub-voxel resolution mean displacement error of registration transformations demonstrates that the algorithm converges to an almost identical solution for forward and reverse registration. (orig.)

  19. Comparative Study of Parametric and Non-parametric Approaches in Fault Detection and Isolation

    DEFF Research Database (Denmark)

    Katebi, S.D.; Blanke, M.; Katebi, M.R.

    This report describes a comparative study between two approaches to fault detection and isolation in dynamic systems. The first approach uses a parametric model of the system. The main components of such techniques are residual and signature generation for processing and analyzing. The second...... approach is non-parametric in the sense that the signature analysis is only dependent on the frequency or time domain information extracted directly from the input-output signals. Based on these approaches, two different fault monitoring schemes are developed where the feature extraction and fault decision...

  20. Markovian Dynamics of Josephson Parametric Amplification

    Directory of Open Access Journals (Sweden)

    W. Kaiser

    2017-09-01

    Full Text Available In this work, we derive the dynamics of the lossy DC pumped non-degenerate Josephson parametric amplifier (DCPJPA. The main element in a DCPJPA is the superconducting Josephson junction. The DC bias generates the AC Josephson current varying the nonlinear inductance of the junction. By this way the Josephson junction acts as the pump oscillator as well as the time varying reactance of the parametric amplifier. In quantum-limited amplification, losses and noise have an increased impact on the characteristics of an amplifier. We outline the classical model of the lossy DCPJPA and derive the available noise power spectral densities. A classical treatment is not capable of including properties like spontaneous emission which is mandatory in case of amplification at the quantum limit. Thus, we derive a quantum mechanical model of the lossy DCPJPA. Thermal losses are modeled by the quantum Langevin approach, by coupling the quantized system to a photon heat bath in thermodynamic equilibrium. The mode occupation in the bath follows the Bose-Einstein statistics. Based on the second quantization formalism, we derive the Heisenberg equations of motion of both resonator modes. We assume the dynamics of the system to follow the Markovian approximation, i.e. the system only depends on its actual state and is memory-free. We explicitly compute the time evolution of the contributions to the signal mode energy and give numeric examples based on different damping and coupling constants. Our analytic results show, that this model is capable of including thermal noise into the description of the DC pumped non-degenerate Josephson parametric amplifier.

  1. Non-parametric smoothing of experimental data

    International Nuclear Information System (INIS)

    Kuketayev, A.T.; Pen'kov, F.M.

    2007-01-01

    Full text: Rapid processing of experimental data samples in nuclear physics often requires differentiation in order to find extrema. Therefore, even at the preliminary stage of data analysis, a range of noise reduction methods are used to smooth experimental data. There are many non-parametric smoothing techniques: interval averages, moving averages, exponential smoothing, etc. Nevertheless, it is more common to use a priori information about the behavior of the experimental curve in order to construct smoothing schemes based on the least squares techniques. The latter methodology's advantage is that the area under the curve can be preserved, which is equivalent to conservation of total speed of counting. The disadvantages of this approach include the lack of a priori information. For example, very often the sums of undifferentiated (by a detector) peaks are replaced with one peak during the processing of data, introducing uncontrolled errors in the determination of the physical quantities. The problem is solvable only by having experienced personnel, whose skills are much greater than the challenge. We propose a set of non-parametric techniques, which allows the use of any additional information on the nature of experimental dependence. The method is based on a construction of a functional, which includes both experimental data and a priori information. Minimum of this functional is reached on a non-parametric smoothed curve. Euler (Lagrange) differential equations are constructed for these curves; then their solutions are obtained analytically or numerically. The proposed approach allows for automated processing of nuclear physics data, eliminating the need for highly skilled laboratory personnel. Pursuant to the proposed approach is the possibility to obtain smoothing curves in a given confidence interval, e.g. according to the χ 2 distribution. This approach is applicable when constructing smooth solutions of ill-posed problems, in particular when solving

  2. Markovian Dynamics of Josephson Parametric Amplification

    Science.gov (United States)

    Kaiser, Waldemar; Haider, Michael; Russer, Johannes A.; Russer, Peter; Jirauschek, Christian

    2017-09-01

    In this work, we derive the dynamics of the lossy DC pumped non-degenerate Josephson parametric amplifier (DCPJPA). The main element in a DCPJPA is the superconducting Josephson junction. The DC bias generates the AC Josephson current varying the nonlinear inductance of the junction. By this way the Josephson junction acts as the pump oscillator as well as the time varying reactance of the parametric amplifier. In quantum-limited amplification, losses and noise have an increased impact on the characteristics of an amplifier. We outline the classical model of the lossy DCPJPA and derive the available noise power spectral densities. A classical treatment is not capable of including properties like spontaneous emission which is mandatory in case of amplification at the quantum limit. Thus, we derive a quantum mechanical model of the lossy DCPJPA. Thermal losses are modeled by the quantum Langevin approach, by coupling the quantized system to a photon heat bath in thermodynamic equilibrium. The mode occupation in the bath follows the Bose-Einstein statistics. Based on the second quantization formalism, we derive the Heisenberg equations of motion of both resonator modes. We assume the dynamics of the system to follow the Markovian approximation, i.e. the system only depends on its actual state and is memory-free. We explicitly compute the time evolution of the contributions to the signal mode energy and give numeric examples based on different damping and coupling constants. Our analytic results show, that this model is capable of including thermal noise into the description of the DC pumped non-degenerate Josephson parametric amplifier.

  3. Reference intervals for serum total cholesterol, HDL cholesterol and ...

    African Journals Online (AJOL)

    Reference intervals of total cholesterol, HDL cholesterol and non-HDL cholesterol concentrations were determined on 309 blood donors from an urban and peri-urban population of Botswana. Using non-parametric methods to establish 2.5th and 97.5th percentiles of the distribution, the intervals were: total cholesterol 2.16 ...

  4. Massively multi-parametric immunoassays using ICPMS

    International Nuclear Information System (INIS)

    Tanner, S.D.; Ornatsky, O.; Bandura, D.R.; Baranov, V.I.

    2009-01-01

    The use of stable isotopes as tags in immunoassays, and their determination by ICPMS, is poised to have a huge impact on multi-parametric bioanalysis. A new technology, which we term 'mass cytometry', enables high throughput, highly multiplexed individual cell analysis. Preliminary results for T-cell immunophenotyping in peripheral blood mononuclear cells (PBMC), agonist influence on concomitant phosphorylation pathways, and sub-classification of acute myeloid leukemia patients' samples will be presented. The significance of individual cell analysis is demonstrated by the identification of populations of rogue cells in PBMC samples through the use of multidimensional neural network cluster analysis. (author)

  5. A parametric evaluation of supersonic STOVL

    Science.gov (United States)

    Kidwell, G. H.; Rapp, D. C.

    1985-01-01

    This paper describes the results of a study to evaluate parametric variations to a single engine short-takeoff vertical-landing fighter/attack aircraft design. The variables considered involved thrust vectoring, thrust degradation, maximum lift, and other changes to determine the impact on short-takeoff performance, but subject to a vertical-landing capability. The results indicate that there are certain parameters that have a significant effect on short-field performance. Also, the optimal control strategies for transitions from a short-takeoff to forward flight and from forward flight to hover are determined. The results have applicability beyond the configuration evaluated.

  6. Semi-parametric estimation for ARCH models

    Directory of Open Access Journals (Sweden)

    Raed Alzghool

    2018-03-01

    Full Text Available In this paper, we conduct semi-parametric estimation for autoregressive conditional heteroscedasticity (ARCH model with Quasi likelihood (QL and Asymptotic Quasi-likelihood (AQL estimation methods. The QL approach relaxes the distributional assumptions of ARCH processes. The AQL technique is obtained from the QL method when the process conditional variance is unknown. We present an application of the methods to a daily exchange rate series. Keywords: ARCH model, Quasi likelihood (QL, Asymptotic Quasi-likelihood (AQL, Martingale difference, Kernel estimator

  7. Parametric resonance in acoustically levitated water drops

    International Nuclear Information System (INIS)

    Shen, C.L.; Xie, W.J.; Wei, B.

    2010-01-01

    Liquid drops can be suspended in air with acoustic levitation method. When the sound pressure is periodically modulated, the levitated drop is usually forced into an axisymmetric oscillation. However, a transition from axisymmetric oscillation into sectorial oscillation occurs when the modulation frequency approaches some specific values. The frequency of the sectorial oscillation is almost exactly half of the modulation frequency. It is demonstrated that this transition is induced by the parametric resonance of levitated drop. The natural frequency of sectorial oscillation is found to decrease with the increase of drop distortion extent.

  8. Parametric resonance in acoustically levitated water drops

    Energy Technology Data Exchange (ETDEWEB)

    Shen, C.L.; Xie, W.J. [Department of Applied Physics, Northwestern Polytechnical University, Xi' an 710072 (China); Wei, B., E-mail: bbwei@nwpu.edu.c [Department of Applied Physics, Northwestern Polytechnical University, Xi' an 710072 (China)

    2010-05-10

    Liquid drops can be suspended in air with acoustic levitation method. When the sound pressure is periodically modulated, the levitated drop is usually forced into an axisymmetric oscillation. However, a transition from axisymmetric oscillation into sectorial oscillation occurs when the modulation frequency approaches some specific values. The frequency of the sectorial oscillation is almost exactly half of the modulation frequency. It is demonstrated that this transition is induced by the parametric resonance of levitated drop. The natural frequency of sectorial oscillation is found to decrease with the increase of drop distortion extent.

  9. Parametric systems analysis for tandem mirror hybrids

    International Nuclear Information System (INIS)

    Lee, J.D.; Chapin, D.L.; Chi, J.W.H.

    1980-09-01

    Fusion fission systems, consisting of fissile producing fusion hybrids combining a tandem mirror fusion driver with various blanket types and net fissile consuming LWR's, have been modeled and analyzed parametrically. Analysis to date indicates that hybrids can be competitive with mined uranium when U 3 O 8 cost is about 100 $/lb., adding less than 25% to present day cost of power from LWR's. Of the three blanket types considered, uranium fast fission (UFF), thorium fast fission (ThFF), and thorium fission supressed (ThFS), the ThFS blanket has a modest economic advantage under most conditions but has higher support ratios and potential safety advantages under all conditions

  10. Parametric Cherenkov radiation (development of idea)

    International Nuclear Information System (INIS)

    Buts, V.A.

    2004-01-01

    Some physical results of researches about charged particles radiation in mediums with a periodic heterogeneity and in periodic potential are reported. The development of ideas Parametric Cherenkov Radiation has shown, that in mediums, which have even a weak degree of a periodic heterogeneity of an permittivity or potential, the nonrelativistic oscillators can radiated as relativistic. They effectively radiate the high numbers of harmonics. In particular, in the carried out experiments the ultra-violet radiation was excited at action on a crystal of intensive ten-centimetric radiation. These results give the reasons to hope for making of nonrelativistic lasers on free electrons

  11. Parametrization relating the fermionic mass spectra

    International Nuclear Information System (INIS)

    Kleppe, A.

    1993-01-01

    When parametrizing the fermionic mass spectra in terms of the unit matrix and a recursive matrix scrR 0 , which corresponds to an underlying scaling pattern in the mass spectra, each fermionic sector is characterized by three parameters: k, α, and R. Using the set of relations displayed by the parameters of the different sectors, it is possible to formulate a ''family Lagrangian'' which for each sector encompasses all the families. Relations between quark masses are furthermore deduced from these ''family Lagrangians.'' Using the relations between the parameters of the different charge sectors, it is also possible to ''derive'' the quark mass spectra from the (charged) leptonic mass spectrum

  12. Parametric Portfolio Policies with Common Volatility Dynamics

    DEFF Research Database (Denmark)

    Ergemen, Yunus Emre; Taamouti, Abderrahim

    A parametric portfolio policy function is considered that incorporates common stock volatility dynamics to optimally determine portfolio weights. Reducing dimension of the traditional portfolio selection problem significantly, only a number of policy parameters corresponding to first- and second......-order characteristics are estimated based on a standard method-of-moments technique. The method, allowing for the calculation of portfolio weight and return statistics, is illustrated with an empirical application to 30 U.S. industries to study the economic activity before and after the recent financial crisis....

  13. Exercise in Configurable Products using Creo parametric

    DEFF Research Database (Denmark)

    Christensen, Georg Kronborg

    2017-01-01

    Family tables is a long know method with ProEngineer/Creo parametric to make families of products – like families of bolts and roller bearings. Configurable Products expand these possibilities in two major ways: First it makes configurable assemblies possible where one topologically different com...... been available as: configurable assemblies in earlier versions of Creo) An example of a practical application of configurable products is shown below where an outdoor Play/Exercise system is transferred from AutoCAD 2D to a 3D configurable product in Creo 3.0....

  14. Quantum phase from s-parametrized quasidistributions

    International Nuclear Information System (INIS)

    Perinova, V; Luks, A

    2005-01-01

    It is familiar that a well behaved operator of the harmonic oscillator phase does not exist. Therefore, Turski's phase operator and the operator of Garrison and Wong may be at most defined in an interesting fashion and yield useful quantum expectation values. In this paper we touch on a recent incomplete definition of a phase operator which has also failed in the respect that it can be completed only to a definition of an 'incomplete' phase operator. We discuss, however, a possibility of completion of the definition and a relationship to the phase operator from an s-parametrized quasidistribution

  15. White-light parametric instabilities in plasmas.

    Science.gov (United States)

    Santos, J E; Silva, L O; Bingham, R

    2007-06-08

    Parametric instabilities driven by partially coherent radiation in plasmas are described by a generalized statistical Wigner-Moyal set of equations, formally equivalent to the full wave equation, coupled to the plasma fluid equations. A generalized dispersion relation for stimulated Raman scattering driven by a partially coherent pump field is derived, revealing a growth rate dependence, with the coherence width sigma of the radiation field, scaling with 1/sigma for backscattering (three-wave process), and with 1/sigma1/2 for direct forward scattering (four-wave process). Our results demonstrate the possibility to control the growth rates of these instabilities by properly using broadband pump radiation fields.

  16. Parametric Amplification of Gravitational Fluctuations during Reheating

    International Nuclear Information System (INIS)

    Finelli, F.; Brandenberger, R.; Finelli, F.

    1999-01-01

    Cosmological perturbations can undergo amplification by parametric resonance during preheating even on scales larger than the Hubble radius, without violating causality. A unified description of gravitational and matter fluctuations is crucial to determine the strength of the instability. To extract specific signatures of the oscillating inflaton field during reheating, it is essential to focus on a variable describing metric fluctuations which is constant in the standard analyses of inflation. For a massive inflaton without self-coupling, we find no additional growth of superhorizon modes during reheating beyond the usual predictions. For a massless self-coupled inflaton, there is a sub-Hubble scale resonance. copyright 1999 The American Physical Society

  17. Ground-Based Telescope Parametric Cost Model

    Science.gov (United States)

    Stahl, H. Philip; Rowell, Ginger Holmes

    2004-01-01

    A parametric cost model for ground-based telescopes is developed using multi-variable statistical analysis, The model includes both engineering and performance parameters. While diameter continues to be the dominant cost driver, other significant factors include primary mirror radius of curvature and diffraction limited wavelength. The model includes an explicit factor for primary mirror segmentation and/or duplication (i.e.. multi-telescope phased-array systems). Additionally, single variable models based on aperture diameter are derived. This analysis indicates that recent mirror technology advances have indeed reduced the historical telescope cost curve.

  18. Preparing Schrodinger cat states by parametric pumping

    Science.gov (United States)

    Leghtas, Zaki; Touzard, Steven; Pop, Ioan; Vlastakis, Brian; Zalys-Geller, Evan; Albert, Victor V.; Jiang, Liang; Frunzio, Luigi; Schoelkopf, Robert J.; Mirrahimi, Mazyar; Devoret, Michel H.

    2014-03-01

    Maintaining a quantum superposition state of light in a cavity has important applications for quantum error correction. We present an experimental protocol based on parametric pumping and Josephson circuits, which could prepare a Schrodinger cat state in a cavity. This is achieved by engineering a dissipative environment, which exchanges only pairs or quadruples of photons with our cavity mode. The dissipative nature of this preparation would lead to the observation of a dynamical Zeno effect, where the competition between a coherent drive and the dissipation reveals non trivial dynamics. Work supported by: IARPA, ARO, and NSF.

  19. PARAMETRIC INSURANCE COVER FOR NATURAL CATASTROPHE RISKS

    Directory of Open Access Journals (Sweden)

    Serghei Margulescu

    2013-11-01

    Full Text Available With economic losses of over USD 370 bn caused by 325 catastrophic events, 2011 ranks as the worst ever year in terms of costs to society due to natural catastrophes and man-made disasters. Inthe same time, 2011 is the second most expensive year in the history for the insurance industry, with insured losses from catastrophic events amounting to USD 116 bn. Both the high level of damages and insured losses, as well as the unprecedented gap between the two values, made insurers and reinsurers worldwide to understand that some risks had so far been underestimated and they have to be better integrated in the catastrophes modelling.On the other hand, governments have to protect themselves against the financial impact of natural catastrophes and new forms of cooperation between the public and private sectors can help countries finance disaster risks. Viewed in a country’s wider risk management context, the purchase of parametric insurance cover, which transfers natural catastrophe risk to the private sector using an index- based trigger, is a necessary shift towards a pre-emptive risk management strategy. This kind of approach can be pursued by central governments or at the level of provincial or municipal governments, and a number of case studies included in the publication “Closing the financial gap” by Swiss Re (2011 illustrates how new forms of parametric insurance can help countries finance disaster risks.

  20. Quantum tomography enhanced through parametric amplification

    Science.gov (United States)

    Knyazev, E.; Spasibko, K. Yu; Chekhova, M. V.; Khalili, F. Ya

    2018-01-01

    Quantum tomography is the standard method of reconstructing the Wigner function of quantum states of light by means of balanced homodyne detection. The reconstruction quality strongly depends on the photodetectors quantum efficiency and other losses in the measurement setup. In this article we analyze in detail a protocol of enhanced quantum tomography, proposed by Leonhardt and Paul [1] which allows one to reduce the degrading effect of detection losses. It is based on phase-sensitive parametric amplification, with the phase of the amplified quadrature being scanned synchronously with the local oscillator phase. Although with sufficiently strong amplification the protocol enables overcoming any detection inefficiency, it was so far not implemented in the experiment, probably due to the losses in the amplifier. Here we discuss a possible proof-of-principle experiment with a traveling-wave parametric amplifier. We show that with the state-of-the-art optical elements, the protocol enables high fidelity tomographic reconstruction of bright non-classical states of light. We consider two examples: bright squeezed vacuum and squeezed single-photon state, with the latter being a non-Gaussian state and both strongly affected by the losses.

  1. Supramodal parametric working memory processing in humans.

    Science.gov (United States)

    Spitzer, Bernhard; Blankenburg, Felix

    2012-03-07

    Previous studies of delayed-match-to-sample (DMTS) frequency discrimination in animals and humans have succeeded in delineating the neural signature of frequency processing in somatosensory working memory (WM). During retention of vibrotactile frequencies, stimulus-dependent single-cell and population activity in prefrontal cortex was found to reflect the task-relevant memory content, whereas increases in occipital alpha activity signaled the disengagement of areas not relevant for the tactile task. Here, we recorded EEG from human participants to determine the extent to which these mechanisms can be generalized to frequency retention in the visual and auditory domains. Subjects performed analogous variants of a DMTS frequency discrimination task, with the frequency information presented either visually, auditorily, or by vibrotactile stimulation. Examining oscillatory EEG activity during frequency retention, we found characteristic topographical distributions of alpha power over visual, auditory, and somatosensory cortices, indicating systematic patterns of inhibition and engagement of early sensory areas, depending on stimulus modality. The task-relevant frequency information, in contrast, was found to be represented in right prefrontal cortex, independent of presentation mode. In each of the three modality conditions, parametric modulations of prefrontal upper beta activity (20-30 Hz) emerged, in a very similar manner as recently found in vibrotactile tasks. Together, the findings corroborate a view of parametric WM as supramodal internal scaling of abstract quantity information and suggest strong relevance of previous evidence from vibrotactile work for a more general framework of quantity processing in human working memory.

  2. Parametric uncertainty in optical image modeling

    Science.gov (United States)

    Potzick, James; Marx, Egon; Davidson, Mark

    2006-10-01

    Optical photomask feature metrology and wafer exposure process simulation both rely on optical image modeling for accurate results. While it is fair to question the accuracies of the available models, model results also depend on several input parameters describing the object and imaging system. Errors in these parameter values can lead to significant errors in the modeled image. These parameters include wavelength, illumination and objective NA's, magnification, focus, etc. for the optical system, and topography, complex index of refraction n and k, etc. for the object. In this paper each input parameter is varied over a range about its nominal value and the corresponding images simulated. Second order parameter interactions are not explored. Using the scenario of the optical measurement of photomask features, these parametric sensitivities are quantified by calculating the apparent change of the measured linewidth for a small change in the relevant parameter. Then, using reasonable values for the estimated uncertainties of these parameters, the parametric linewidth uncertainties can be calculated and combined to give a lower limit to the linewidth measurement uncertainty for those parameter uncertainties.

  3. Vector parametrization, partial angular momenta and unusual commutation relations in physics

    International Nuclear Information System (INIS)

    Gatti, Fabien; Nauts, Andre

    2003-01-01

    When studying an N-particle system by means of N-1 vectors i.e., by means of a vector parametrization, one unavoidably comes across several angular momenta: not only the total angular momentum of the system but also the various partial angular momenta corresponding to the motion of the various vectors. All these momenta can, in addition, be referred to a variety of reference frames. The use of vector parametrizations and partial angular momenta in physics greatly simplifies the classical as well as quantum expressions of the kinetic energy. The present paper is devoted to a detailed and rigorous study of the partial angular momenta and the various commutation relations they satisfy, in particular the unusual commutation relations whose origin is traced back to the very structure of the coordinate changes used to define the Body-Fixed (BF) frames. The direct quantization of the classical expressions of the kinetic energy obtained in the context of various vector parametrizations is also given in detail. It turns out to be an efficient extension of well-known quantization procedures to the case where supernumerary quasi-momenta are used. As an illustration, the case of a four-particle system is treated in detail for a particular choice of the BF frames. Finally, the analogies between the classical and quantum approaches are emphasized

  4. GHz-rate optical parametric amplifier in hydrogenated amorphous silicon

    International Nuclear Information System (INIS)

    Wang, Ke-Yao; Foster, Amy C

    2015-01-01

    We demonstrate optical parametric amplification operating at GHz-rates at telecommunications wavelengths using a hydrogenated amorphous silicon waveguide through the nonlinear optical process of four-wave mixing. We investigate how the parametric amplification scales with repetition rate. The ability to achieve amplification at GHz-repetition rates shows hydrogenated amorphous silicon’s potential for telecommunication applications and a GHz-rate optical parametric oscillator. (paper)

  5. Synchronization of chaos in non-identical parametrically excited systems

    International Nuclear Information System (INIS)

    Idowu, B.A.; Vincent, U.E.; Njah, A.N.

    2009-01-01

    In this paper, we investigate the synchronization of chaotic systems consisting of non-identical parametrically excited oscillators. The active control technique is employed to design control functions based on Lyapunov stability theory and Routh-Hurwitz criteria so as to achieve global chaos synchronization between a parametrically excited gyroscope and each of the parametrically excited pendulum and Duffing oscillator. Numerical simulations are implemented to verify the results.

  6. Absolute decay parametric instability of high-temperature plasma

    International Nuclear Information System (INIS)

    Zozulya, A.A.; Silin, V.P.; Tikhonchuk, V.T.

    1986-01-01

    A new absolute decay parametric instability having wide spatial localization region is shown to be possible near critical plasma density. Its excitation is conditioned by distributed feedback of counter-running Langmuir waves occurring during parametric decay of incident and reflected pumping wave components. In a hot plasma with the temperature of the order of kiloelectronvolt its threshold is lower than that of a known convective decay parametric instability. Minimum absolute instability threshold is shown to be realized under conditions of spatial parametric resonance of higher orders

  7. Parametric and alternative studies for fusion experimental reactor (FER) (FY 1984)

    International Nuclear Information System (INIS)

    1986-01-01

    Since 1980 the design study has been conducted at JAERI for the Fusion Experimental Reactor (FER) which has been proposed to be the next machine to JT-60 in the Japanese long term program of fusion reactor development. Starting from 1984 FER design is being reviewed and redesigned. This report is a part of the interim report which describes the results obtained in the review and redesign activities in FY 1984. This report includes the following parametric and alternative studies for the FER reference design: 1) parametric studies concerning with core plasma magnets, and operation scenario and power supply, 2) tritium breeding blanket, 3) the study for the steady state operation FER, 4) OTHERS. (AUTHOR)

  8. Parametric imaging technique for visualization of esophageal motility and its disorders

    International Nuclear Information System (INIS)

    Tatsch, K.; Knesewitsch, P.; Moser, E.

    1987-01-01

    Fifty-eight healthy individuals and patients with esophageal dysfunction (achalasia, reflux, morphea, PSS, Sharp syndrome) were studied with esophageal parametric imaging (EPI) (acquisition of 15-20 swallows per patient; image creation by special ''space time'' matrix) and results were compared with standard esophageal function scintigraphy (EPS). We could demonstrate that normal function and motility disorders result in defined parametric image patterns. Pathologic findings on EFS always showed abnormal findings on EPI. Normal findings on EPI always showed normal findings on EFS. However, ten of 15 patients with normal EFS had pathologic EPI. Compared with EFS, evaluation of dysfunction in EPI is not referred to single but multiple swallowing and demonstrated a higher sensitivity by comparable specificity

  9. Parametric resonance in quantum electrodynamics vacuum birefringence

    Science.gov (United States)

    Arza, Ariel; Elias, Ricardo Gabriel

    2018-05-01

    Vacuum magnetic birefringence is one of the most interesting nonlinear phenomena in quantum electrodynamics because it is a pure photon-photon result of the theory and it directly signalizes the violation of the classical superposition principle of electromagnetic fields in the full quantum theory. We perform analytical and numerical calculations when an electromagnetic wave interacts with an oscillating external magnetic field. We find that in an ideal cavity, when the external field frequency is around the electromagnetic wave frequency, the normal and parallel components of the wave suffer parametric resonance at different rates, producing a vacuum birefringence effect growing in time. We also study the case where there is no cavity and the oscillating magnetic field is spatially localized in a region of length L . In both cases we find also a rotation of the elliptical axis.

  10. Parametric time-frequency domain spatial audio

    CERN Document Server

    Delikaris-Manias, Symeon; Politis, Archontis

    2018-01-01

    This book provides readers with the principles and best practices in spatial audio signal processing. It describes how sound fields and their perceptual attributes are captured and analyzed within the time-frequency domain, how essential representation parameters are coded, and how such signals are efficiently reproduced for practical applications. The book is split into four parts starting with an overview of the fundamentals. It then goes on to explain the reproduction of spatial sound before offering an examination of signal-dependent spatial filtering. The book finishes with coverage of both current and future applications and the direction that spatial audio research is heading in. Parametric Time-frequency Domain Spatial Audio focuses on applications in entertainment audio, including music, home cinema, and gaming--covering the capturing and reproduction of spatial sound as well as its generation, transduction, representation, transmission, and perception. This book will teach readers the tools needed...

  11. Parametric HMMs for Movement Recognition and Synthesis

    DEFF Research Database (Denmark)

    Herzog, Dennis; Krüger, Volker

    2009-01-01

    , we develop an exemplar-based parametric hidden Markov model (PHMM) that allows to represent movements of a particular type. Since we use model interpolation to reduce the necessary amount of training data, we had to develop a method to setup local models in a synchronized way. In our experiments we......A common problem in human movement recognition is the recognition of movements of a particular type (semantic). E.g., grasping movements have a particular semantic (grasping) but the actual movements usually have very different appearances due to, e.g., different grasping directions. In this paper...... to recover the movement type, and, e.g., the object position a human is pointing at. Our experiments show the flexibility of the PHMMs in terms of the amount of training data and its robustness in terms of noisy observation data. In addition, we compare our PHMM to an other kind of PHMM, which has been...

  12. Parametric resonance and cosmological gravitational waves

    International Nuclear Information System (INIS)

    Sa, Paulo M.; Henriques, Alfredo B.

    2008-01-01

    We investigate the production of gravitational waves due to quantum fluctuations of the vacuum during the transition from the inflationary to the radiation-dominated eras of the universe, assuming this transition to be dominated by the phenomenon of parametric resonance. The energy spectrum of the gravitational waves is calculated using the method of continuous Bogoliubov coefficients, which avoids the problem of overproduction of gravitons at large frequencies. We found, on the sole basis of the mechanism of quantum fluctuations, that the resonance field leaves no explicit and distinctive imprint on the gravitational-wave energy spectrum, apart from an overall upward or downward translation. Therefore, the main features in the spectrum are due to the inflaton field, which leaves a characteristic imprint at frequencies of the order of MHz/GHz.

  13. Parametric description of the quantum measurement process

    Science.gov (United States)

    Liuzzo-Scorpo, P.; Cuccoli, A.; Verrucchi, P.

    2015-08-01

    We present a description of the measurement process based on the parametric representation with environmental coherent states. This representation is specifically tailored for studying quantum systems whose environment needs being considered through the quantum-to-classical crossover. Focusing upon projective measures, and exploiting the connection between large-N quantum theories and the classical limit of related ones, we manage to push our description beyond the pre-measurement step. This allows us to show that the outcome production follows from a global-symmetry breaking, entailing the observed system's state reduction, and that the statistical nature of the process is brought about, together with the Born's rule, by the macroscopic character of the measuring apparatus.

  14. Parametric Design Strategies for Collaborative Urban Design

    DEFF Research Database (Denmark)

    Steinø, Nicolai; Yıldırım, Miray Baş; Özkar, Mine

    2013-01-01

    to the collaboration between professionals, participation by different non-professional stakeholders, such as residents, local authorities, non-governmental organizations and investors, is another important component of collaborative urban design processes. The involvement of community in decision making process...... implications of planning and design decisions, unless they are presented with relatively detailed architectural models, whether physical or virtual. This however, typically presents steep demands in terms of time and resources. As a foundation for our work with parametric urban design lies the hypothesis...... to solve different scripting challenges. The paper is organized into an introduction, three main sections and closing section with conclusions and perspectives. The first section of the paper gives a theoretical discussion of the notion of collaborative design and the challenges of collaborative urban...

  15. Parametric systems analysis for ICF hybrid reactors

    International Nuclear Information System (INIS)

    Berwald, D.H.; Maniscalco, J.A.; Chapin, D.L.

    1981-01-01

    Parametric design and systems analysis for inertial confinement fusion-fission hybrids are presented. These results were generated as part of the Electric Power Research Institute (EPRI) sponsored Feasibility Assessment of Fusion-Fission Hybrids, using an Inertial Confinement Fusion (ICF) hybrid power plant design code developed in conjunction with the feasibility assessment. The SYMECON systems analysis code, developed by Westinghouse, was used to generate economic results for symbiotic electricity generation systems consisting of the hybrid and its client Light Water Reactors (LWRs). These results explore the entire fusion parameter space for uranium fast fission blanket hybrids, thorium fast fission blanket hybrids, and thorium suppressed fission blanket types are discussed, and system sensitivities to design uncertainties are explored

  16. Simplifying the circuit of Josephson parametric converters

    Science.gov (United States)

    Abdo, Baleegh; Brink, Markus; Chavez-Garcia, Jose; Keefe, George

    Josephson parametric converters (JPCs) are quantum-limited three-wave mixing devices that can play various important roles in quantum information processing in the microwave domain, including amplification of quantum signals, transduction of quantum information, remote entanglement of qubits, nonreciprocal amplification, and circulation of signals. However, the input-output and biasing circuit of a state-of-the-art JPC consists of bulky components, i.e. two commercial off-chip broadband 180-degree hybrids, four phase-matched short coax cables, and one superconducting magnetic coil. Such bulky hardware significantly hinders the integration of JPCs in scalable quantum computing architectures. In my talk, I will present ideas on how to simplify the JPC circuit and show preliminary experimental results

  17. Spherical Parametrization of the Higgs Boson Candidate

    CERN Document Server

    Gainer, James S; Matchev, Konstantin T; Mrenna, Stephen; Park, Myeonghun

    2013-01-01

    The latest results from the ATLAS and CMS experiments at the CERN Large Hadron Collider (LHC) unequivocally confirm the existence of a resonance, $X$, with mass near 125 GeV which could be the Higgs boson of the Standard Model. Measuring the properties (quantum numbers and couplings) of this resonance is of paramount importance. Initial analyses by the LHC collaborations disfavor specific alternative benchmark hypotheses, e.g. pure pseudoscalars or gravitons. However, this is just the first step in a long-term program of detailed measurements. We consider the most general set of operators in the decay channels $X \\to ZZ$, $WW$, $Z\\gamma$, $\\gamma\\gamma$ and derive the constraint implied by the measured rate. This allows us to provide a useful parametrization of the orthogonal independent Higgs coupling degrees of freedom as coordinates on a suitably defined sphere.

  18. Examples in parametric inference with R

    CERN Document Server

    Dixit, Ulhas Jayram

    2016-01-01

    This book discusses examples in parametric inference with R. Combining basic theory with modern approaches, it presents the latest developments and trends in statistical inference for students who do not have an advanced mathematical and statistical background. The topics discussed in the book are fundamental and common to many fields of statistical inference and thus serve as a point of departure for in-depth study. The book is divided into eight chapters: Chapter 1 provides an overview of topics on sufficiency and completeness, while Chapter 2 briefly discusses unbiased estimation. Chapter 3 focuses on the study of moments and maximum likelihood estimators, and Chapter 4 presents bounds for the variance. In Chapter 5, topics on consistent estimator are discussed. Chapter 6 discusses Bayes, while Chapter 7 studies some more powerful tests. Lastly, Chapter 8 examines unbiased and other tests. Senior undergraduate and graduate students in statistics and mathematics, and those who have taken an introductory cou...

  19. Stellar parametrization from Gaia RVS spectra

    Science.gov (United States)

    Recio-Blanco, A.; de Laverny, P.; Allende Prieto, C.; Fustes, D.; Manteiga, M.; Arcay, B.; Bijaoui, A.; Dafonte, C.; Ordenovic, C.; Ordoñez Blanco, D.

    2016-01-01

    Context. Among the myriad of data collected by the ESA Gaia satellite, about 150 million spectra will be delivered by the Radial Velocity Spectrometer (RVS) for stars as faint as GRVS~ 16. A specific stellar parametrization will be performed on most of these RVS spectra, I.e. those with enough high signal-to-noise ratio (S/N), which should correspond to single stars that have a magnitude in the RVS band brighter than ~14.5. Some individual chemical abundances will also be estimated for the brightest targets. Aims: We describe the different parametrization codes that have been specifically developed or adapted for RVS spectra within the GSP-Spec working group of the analysis consortium. The tested codes are based on optimisation (FERRE and GAUGUIN), projection (MATISSE), or pattern-recognition methods (Artificial Neural Networks). We present and discuss each of their expected performances in the recovered stellar atmospheric parameters (effective temperature, surface gravity, overall metallicity) for B- to K-type stars. The performances for determining of [α/Fe] ratios are also presented for cool stars. Methods: Each code has been homogeneously tested with a large grid of RVS simulated synthetic spectra of BAFGK-spectral types (dwarfs and giants), with metallicities varying from 10-2.5 to 10+ 0.5 the solar metallicity, and taking variations of ±0.4 dex in the composition of the α-elements into consideration. The tests were performed for S/N ranging from ten to 350. Results: For all the stellar types we considered, stars brighter than GRVS~ 12.5 are very efficiently parametrized by the GSP-Spec pipeline, including reliable estimations of [α/Fe]. Typical internal errors for FGK metal-rich and metal-intermediate stars are around 40 K in Teff, 0.10 dex in log(g), 0.04 dex in [M/H], and 0.03 dex in [α/Fe] at GRVS = 10.3. They degrade to 155 K in Teff, 0.15 dex in log(g), 0.10 dex in [M/H], and 0.1 dex in [α/Fe] at GRVS~ 12. Similar accuracies in Teff and [M/H] are

  20. Parametric inference for biological sequence analysis.

    Science.gov (United States)

    Pachter, Lior; Sturmfels, Bernd

    2004-11-16

    One of the major successes in computational biology has been the unification, by using the graphical model formalism, of a multitude of algorithms for annotating and comparing biological sequences. Graphical models that have been applied to these problems include hidden Markov models for annotation, tree models for phylogenetics, and pair hidden Markov models for alignment. A single algorithm, the sum-product algorithm, solves many of the inference problems that are associated with different statistical models. This article introduces the polytope propagation algorithm for computing the Newton polytope of an observation from a graphical model. This algorithm is a geometric version of the sum-product algorithm and is used to analyze the parametric behavior of maximum a posteriori inference calculations for graphical models.

  1. Toward a compact fibered squeezing parametric source.

    Science.gov (United States)

    Brieussel, Alexandre; Ott, Konstantin; Joos, Maxime; Treps, Nicolas; Fabre, Claude

    2018-03-15

    In this work, we investigate three different compact fibered systems generating vacuum squeezing that involve optical cavities limited by the end surface of a fiber and by a curved mirror and containing a thin parametric crystal. These systems have the advantage to couple squeezed states directly to a fiber, allowing the user to benefit from the flexibility of fibers in the use of squeezing. Three types of fibers are investigated: standard single-mode fibers, photonic-crystal large-mode-area single-mode fibers, and short multimode fibers taped to a single-mode fiber. The observed squeezing is modest (-0.56  dB, -0.9  dB, -1  dB), but these experiments open the way for miniaturized squeezing devices that could be a very interesting advantage in scaling up quantum systems for quantum processing, opening new perspectives in the domain of integrated quantum optics.

  2. Normal dispersion femtosecond fiber optical parametric oscillator.

    Science.gov (United States)

    Nguyen, T N; Kieu, K; Maslov, A V; Miyawaki, M; Peyghambarian, N

    2013-09-15

    We propose and demonstrate a synchronously pumped fiber optical parametric oscillator (FOPO) operating in the normal dispersion regime. The FOPO generates chirped pulses at the output, allowing significant pulse energy scaling potential without pulse breaking. The output average power of the FOPO at 1600 nm was ∼60  mW (corresponding to 1.45 nJ pulse energy and ∼55% slope power conversion efficiency). The output pulses directly from the FOPO were highly chirped (∼3  ps duration), and they could be compressed outside of the cavity to 180 fs by using a standard optical fiber compressor. Detailed numerical simulation was also performed to understand the pulse evolution dynamics around the laser cavity. We believe that the proposed design concept is useful for scaling up the pulse energy in the FOPO using different pumping wavelengths.

  3. Parametric uncertainty modeling for robust control

    DEFF Research Database (Denmark)

    Rasmussen, K.H.; Jørgensen, Sten Bay

    1999-01-01

    The dynamic behaviour of a non-linear process can often be approximated with a time-varying linear model. In the presented methodology the dynamics is modeled non-conservatively as parametric uncertainty in linear lime invariant models. The obtained uncertainty description makes it possible...... to perform robustness analysis on a control system using the structured singular value. The idea behind the proposed method is to fit a rational function to the parameter variation. The parameter variation can then be expressed as a linear fractional transformation (LFT), It is discussed how the proposed...... point changes. It is shown that a diagonal PI control structure provides robust performance towards variations in feed flow rate or feed concentrations. However including both liquid and vapor flow delays robust performance specifications cannot be satisfied with this simple diagonal control structure...

  4. Parametric resonance and cosmological gravitational waves

    Science.gov (United States)

    Sá, Paulo M.; Henriques, Alfredo B.

    2008-03-01

    We investigate the production of gravitational waves due to quantum fluctuations of the vacuum during the transition from the inflationary to the radiation-dominated eras of the universe, assuming this transition to be dominated by the phenomenon of parametric resonance. The energy spectrum of the gravitational waves is calculated using the method of continuous Bogoliubov coefficients, which avoids the problem of overproduction of gravitons at large frequencies. We found, on the sole basis of the mechanism of quantum fluctuations, that the resonance field leaves no explicit and distinctive imprint on the gravitational-wave energy spectrum, apart from an overall upward or downward translation. Therefore, the main features in the spectrum are due to the inflaton field, which leaves a characteristic imprint at frequencies of the order of MHz/GHz.

  5. Parametric cost estimation for space science missions

    Science.gov (United States)

    Lillie, Charles F.; Thompson, Bruce E.

    2008-07-01

    Cost estimation for space science missions is critically important in budgeting for successful missions. The process requires consideration of a number of parameters, where many of the values are only known to a limited accuracy. The results of cost estimation are not perfect, but must be calculated and compared with the estimates that the government uses for budgeting purposes. Uncertainties in the input parameters result from evolving requirements for missions that are typically the "first of a kind" with "state-of-the-art" instruments and new spacecraft and payload technologies that make it difficult to base estimates on the cost histories of previous missions. Even the cost of heritage avionics is uncertain due to parts obsolescence and the resulting redesign work. Through experience and use of industry best practices developed in participation with the Aerospace Industries Association (AIA), Northrop Grumman has developed a parametric modeling approach that can provide a reasonably accurate cost range and most probable cost for future space missions. During the initial mission phases, the approach uses mass- and powerbased cost estimating relationships (CER)'s developed with historical data from previous missions. In later mission phases, when the mission requirements are better defined, these estimates are updated with vendor's bids and "bottoms- up", "grass-roots" material and labor cost estimates based on detailed schedules and assigned tasks. In this paper we describe how we develop our CER's for parametric cost estimation and how they can be applied to estimate the costs for future space science missions like those presented to the Astronomy & Astrophysics Decadal Survey Study Committees.

  6. Parametric representation of centrifugal pump homologous curves

    International Nuclear Information System (INIS)

    Veloso, Marcelo A.; Mattos, Joao R.L. de

    2015-01-01

    Essential for any mathematical model designed to simulate flow transient events caused by pump operations is the pump performance data. The performance of a centrifugal pump is characterized by four basic quantities: the rotational speed, the volumetric flow rate, the dynamic head, and the hydraulic torque. The curves showing the relationships between these four variables are called the pump characteristic curves. The characteristic curves are empirically developed by the pump manufacturer and uniquely describe head and torque as functions of volumetric flow rate and rotation speed. Because of comprising a large amount of points, this configuration is not suitable for computational purposes. However, it can be converted to a simpler form by the development of the homologous curves, in which dynamic head and hydraulic torque ratios are expressed as functions of volumetric flow and rotation speed ratios. The numerical use of the complete set of homologous curves requires specification of sixteen partial curves, being eight for the dynamic head and eight for the hydraulic torque. As a consequence, the handling of homologous curves is still somewhat complicated. In solving flow transient problems that require the pump characteristic data for all the operation zones, the parametric form appears as the simplest way to deal with the homologous curves. In this approach, the complete characteristics of a pump can be described by only two closed curves, one for the dynamic head and other for the hydraulic torque, both in function of a single angular coordinate defined adequately in terms of the quotient between volumetric flow ratio and rotation speed ratio. The usefulness and advantages of this alternative method are demonstrated through a practical example in which the homologous curves for a pump of the type used in the main coolant loops of a pressurized water reactor (PWR) are transformed to the parametric form. (author)

  7. Parametric amplifications in the nonlinear transmission line

    Energy Technology Data Exchange (ETDEWEB)

    Kawata, T; Sakai, J; Inoue, H [Toyama Univ., Takaoka (Japan). Faculty of Engineering

    1980-03-01

    The parametric amplification in a transmission line with nonlinear capacitors is analysed theoretically using the equations of three wave interactions. Since this line has two modes, high frequency and low frequency modes, there may occur some mode coupling phenomena through the resonant interactions. We consider three waves with wave number k sub(j) and frequency ..omega..sub(j) in resonance with each other, that is, ..omega../sub 1/ + ..omega../sub 2/ = ..omega../sub 3/ and k/sub 1/ + k/sub 2/ = k/sub 3/, where 0 <= ..omega../sub 1/ <= ..omega../sub 2/ <= ..omega../sub 3/ and k/sub 3/ >= 0. Such conditions are realized in our network and there exist two states: ''forward state'' (each group velocity is positive) and ''backward state'' (one of the group velocities is negative). The coupled equations of three waves has two constant pumps: high frequency (HF) pump and low frequency (LF) pump. Using linear approximations, we examine the possible types of parametric amplification and obtain the power gains depending on the frequency deviation. For only the case of HF pump we get the gain between signals with seme frequency and also get the gain from the low frequency signal to the high frequency signal (''up-conversion'') for the LF pump. The nonlinear analysis gives the exact relation between input and output signals. For the forward state the gain is absolutely suppressed by the ratio of pumping power to input power, while the gain of backward state has no finite maximum and there may appear an ''oscillating state'' if the pumping power is comparatively small.

  8. Evaluation of Two Energy Balance Closure Parametrizations

    Science.gov (United States)

    Eder, Fabian; De Roo, Frederik; Kohnert, Katrin; Desjardins, Raymond L.; Schmid, Hans Peter; Mauder, Matthias

    2014-05-01

    A general lack of energy balance closure indicates that tower-based eddy-covariance (EC) measurements underestimate turbulent heat fluxes, which calls for robust correction schemes. Two parametrization approaches that can be found in the literature were tested using data from the Canadian Twin Otter research aircraft and from tower-based measurements of the German Terrestrial Environmental Observatories (TERENO) programme. Our analysis shows that the approach of Huang et al. (Boundary-Layer Meteorol 127:273-292, 2008), based on large-eddy simulation, is not applicable to typical near-surface flux measurements because it was developed for heights above the surface layer and over homogeneous terrain. The biggest shortcoming of this parametrization is that the grid resolution of the model was too coarse so that the surface layer, where EC measurements are usually made, is not properly resolved. The empirical approach of Panin and Bernhofer (Izvestiya Atmos Oceanic Phys 44:701-716, 2008) considers landscape-level roughness heterogeneities that induce secondary circulations and at least gives a qualitative estimate of the energy balance closure. However, it does not consider any feature of landscape-scale heterogeneity other than surface roughness, such as surface temperature, surface moisture or topography. The failures of both approaches might indicate that the influence of mesoscale structures is not a sufficient explanation for the energy balance closure problem. However, our analysis of different wind-direction sectors shows that the upwind landscape-scale heterogeneity indeed influences the energy balance closure determined from tower flux data. We also analyzed the aircraft measurements with respect to the partitioning of the "missing energy" between sensible and latent heat fluxes and we could confirm the assumption of scalar similarity only for Bowen ratios 1.

  9. Parametric Statistics of Individual Energy Levels in Random Hamiltonians

    OpenAIRE

    Smolyarenko, I. E.; Simons, B. D.

    2002-01-01

    We establish a general framework to explore parametric statistics of individual energy levels in disordered and chaotic quantum systems of unitary symmetry. The method is applied to the calculation of the universal intra-level parametric velocity correlation function and the distribution of level shifts under the influence of an arbitrary external perturbation.

  10. Design and development of a parametrically excited nonlinear energy harvester

    International Nuclear Information System (INIS)

    Yildirim, Tanju; Ghayesh, Mergen H.; Li, Weihua; Alici, Gursel

    2016-01-01

    Highlights: • A parametrically broadband energy harvester was fabricated. • Strong softening-type nonlinear behaviour was observed. • Experiments were conducted showing the large bandwidth of the device. - Abstract: An energy harvester has been designed, fabricated and tested based on the nonlinear dynamical response of a parametrically excited clamped-clamped beam with a central point-mass; magnets have been used as the central point-mass which pass through a coil when parametrically excited. Experiments have been conducted for the energy harvester when the system is excited (i) harmonically near the primary resonance; (ii) harmonically near the principal parametric resonance; (iii) by means of a non-smooth periodic excitation. An electrodynamic shaker was used to parametrically excite the system and the corresponding displacement of the magnet and output voltages of the coil were measured. It has been shown that the system displays linear behaviour at the primary resonance; however, at the principal parametric resonance, the motion characteristic of the magnet substantially changed displaying a strong softening-type nonlinearity. Theoretical simulations have also been conducted in order to verify the experimental results; the comparison between theory and experiment were within very good agreement of each other. The energy harvester developed in this paper is capable of harvesting energy close to the primary resonance as well as the principal parametric resonance; the frequency-band has been broadened significantly mainly due to the nonlinear effects as well as the parametric excitation.

  11. QCD parametrizations of the parton distribution of deep inelastic scattering

    International Nuclear Information System (INIS)

    Kotikov, A.V.; Maksimov, S.J.; Parobij, I.S.

    1993-01-01

    A realistic parametrization of the gluon and quarks distributions is suggested. It is shown that the solutions of the Gribov-Lipatov-Altarelli-Paris equations can be presented by these parametrizations and these equations unambiguously lead to the constraints on the Q 2 -evolution of the parameters. (author). 10 refs

  12. Parametric excitation of drift waves in a sheared slab geometry

    International Nuclear Information System (INIS)

    Vranjes, J.; Weiland, J.

    1992-01-01

    The threshold for parametric excitation of drift waves in a sheared slab geometry is calculated for a pump wave that is a standing wave along the magnetic field, using the Hasegawa-Mima nonlinearity. The shear damping is counteracted by the parametric coupling and the eigenvalue problem is solved analytically using Taylor's strong coupling approximation. (au)

  13. Additivity for parametrized topological Euler characteristic and Reidemeister torsion

    OpenAIRE

    Badzioch, Bernard; Dorabiala, Wojciech

    2005-01-01

    Dwyer, Weiss, and Williams have recently defined the notions of parametrized topological Euler characteristic and parametrized topological Reidemeister torsion which are invariants of bundles of compact topological manifolds. We show that these invariants satisfy additivity formulas paralleling the additive properties of the classical Euler characteristic and Reidemeister torsion of finite CW-complexes.

  14. Schwinger-type parametrization of open string worldsheets

    Directory of Open Access Journals (Sweden)

    Sam Playle

    2017-03-01

    Full Text Available A parametrization of (super moduli space near the corners corresponding to bosonic or Neveu–Schwarz open string degenerations is introduced for worldsheets of arbitrary topology. With this parametrization, Feynman graph polynomials arise as the α′→0 limit of objects on moduli space. Furthermore, the integration measures of string theory take on a very simple and elegant form.

  15. Parametric Cost and Schedule Modeling for Early Technology Development

    Science.gov (United States)

    2018-04-02

    Research NoteNational Security Rep rt PARAMETRIC MODELING FOR EARLY TECHNOLOGY DEVELOPMENT COST AND SCHEDULE Chuck...Alexander NSR_11x17_Cover_CostModeling_v8.indd 1 11/20/17 3:15 PM PARAMETRIC COST AND SCHEDULE MODELING FOR EARLY  TECHNOLOGY DEVELOPMENT Chuck...COST AND SCHEDULE MODELING FOR EARLY  TECHNOLOGY DEVELOPMENT iii Contents Figures

  16. Parametric Room Acoustic workflows with real-time acoustic simulation

    DEFF Research Database (Denmark)

    Parigi, Dario

    2017-01-01

    The paper investigates and assesses the opportunities that real-time acoustic simulation offer to engage in parametric acoustics workflow and to influence architectural designs from early design stages......The paper investigates and assesses the opportunities that real-time acoustic simulation offer to engage in parametric acoustics workflow and to influence architectural designs from early design stages...

  17. Parametric Equations: Push 'Em Back, Push 'Em Back, Way Back!

    Science.gov (United States)

    Cieply, Joseph F.

    1993-01-01

    Stresses using the features of graphing calculators to teach parametric equations much earlier in the curriculum than is presently done. Examples using parametric equations to teach slopes and lines in beginning algebra, inverse functions in advanced algebra, the wrapping function, and simulations of physical phenomena are presented. (MAZ)

  18. A PARAMETRIC STUDY OF THE INFLUENCE OF SHORT-TERM ...

    African Journals Online (AJOL)

    (b). (•). Figure I a) The building embedded in a layered formation; b) The building model with base springs. PARAMETRIC STUDY. 'fhe parametric study carried out in this work aims at investigating the effect of the soil flexibility on the internal force distribution of selected structural systems of buildings that are founded on soil.

  19. PISC II: Parametric studies. Monitoring of PISC-II parametric studies in ultrasonic NDT for PWR

    International Nuclear Information System (INIS)

    Toft, M.W.

    1989-09-01

    The CEGB NDT Applications Centre is partipating in the EEC-funded international Programme for the Inspection of Steel Components (PISC) on account of its relevance to the inspection of Sizewell B and future PWRs. This report describes an inspection monitoring exercise undertaken by NDTAC under partial funding from JRC Ispra, at the initiation of the PISC-III Ultrasonic Modelling Group. Experimental studies have been carried out under PISC-II to investigate ultrasonic defect response as a function of various parameters which characterise the inspection situation. Some of these parametric studies are potentially useful for the validation of theoretical models of ultrasonic inspection and are consequently relevant to the work of the PISC-III Modelling Group. The aim of the present exercise was to ensure that data obtained by the various contract organizations participating in the PISC-II Parametric Studies was of high quality, was a complete record of the inspection and would yield valid comparisons with the predictions of theoretical models. The exercise entailed visits by a nominated CEGB observer to 4 European NDT Laboratories at which the parametric studies were in progress; CISE (Milan); UKAEA (Harwell); UKAEA (Risley) and Vincotte (Brussels). This report presents the findings of those visits

  20. Autonomous Supervision and Control of Parametric Roll Resonance

    DEFF Research Database (Denmark)

    Galeazzi, Roberto

    therefore two objectives. The first is to develop methods for detection of the inception of parametric roll resonance. The second is to develop control strategies to stabilize the motion after parametric roll has started. Stabilisation of parametric roll resonance points to two possible courses of action...... strategies are then combined to stabilise parametric roll resonance within few roll cycles. Limitations on the maximum stabilisable roll angle are analysed and linked to the ii slew rate saturation and hydrodynamic stall characteristics of the fin stabilisers. The study on maximum stabilisable roll angle...... leads to the requirements for early detection. Two novel detectors are proposed, which work within a shorttime prediction horizon, and issue early warnings of parametric roll inception within few roll cycles from its onset. The main idea behind these detection schemes is that of exploiting the link...

  1. Parametric Instability in Advanced Laser Interferometer Gravitational Wave Detectors

    International Nuclear Information System (INIS)

    Ju, L; Grass, S; Zhao, C; Degallaix, J; Blair, D G

    2006-01-01

    High frequency parametric instabilities in optical cavities are radiation pressure induced interactions between test mass mechanical modes and cavity optical modes. The parametric gain depends on the cavity power and the quality factor of the test mass internal modes (usually in ultrasonic frequency range), as well as the overlap integral for the mechanical and optical modes. In advanced laser interferometers which require high optical power and very low acoustic loss test masses, parametric instabilities could prevent interferometer operation if not suppressed. Here we review the problem of parametric instabilities in advanced detector configurations for different combinations of sapphire and fused silica test masses, and compare three methods for control or suppression of parametric instabilities-thermal tuning, surface damping and active feedback

  2. The relevance of parametric U-uptake models in ESR age calculations

    International Nuclear Information System (INIS)

    Gruen, Rainer

    2009-01-01

    In the ESR dating three basic parametric U-uptake models have been applied for dating teeth: early U-uptake (EU: closed system), linear U-uptake (LU) and recent U-uptake (RU, it is assumed that the dose rate contribution of U in the dental tissues is zero). In many ESR dating publications it is still assumed that samples comply with one or the other parametric U-uptake model calculation or that their correct age lies somewhere between EU and LU. Observations of the spatial distribution of uranium in dental tissues show that it is difficult to predict any relationships between the relative uptake in the dental tissues. Combined U-series/ESR age estimates can give insights into the actual U-uptake. An evaluation of published data shows that for cave sites, a significant number of results fall outside the EU and LU bracket, while for open air sites, the majority of data are outside this bracket, particularly showing greatly delayed U-uptake. This may be due to changes in the hydrological system, leading to erosion which exposes the open air site. U-leaching has also been observed on samples from open air sites, in which case any reasonable age calculation is impossible.

  3. Tissue engineering

    CERN Document Server

    Fisher, John P; Bronzino, Joseph D

    2007-01-01

    Increasingly viewed as the future of medicine, the field of tissue engineering is still in its infancy. As evidenced in both the scientific and popular press, there exists considerable excitement surrounding the strategy of regenerative medicine. To achieve its highest potential, a series of technological advances must be made. Putting the numerous breakthroughs made in this field into a broad context, Tissue Engineering disseminates current thinking on the development of engineered tissues. Divided into three sections, the book covers the fundamentals of tissue engineering, enabling technologies, and tissue engineering applications. It examines the properties of stem cells, primary cells, growth factors, and extracellular matrix as well as their impact on the development of tissue engineered devices. Contributions focus on those strategies typically incorporated into tissue engineered devices or utilized in their development, including scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene t...

  4. A physiology-based parametric imaging method for FDG-PET data

    Science.gov (United States)

    Scussolini, Mara; Garbarino, Sara; Sambuceti, Gianmario; Caviglia, Giacomo; Piana, Michele

    2017-12-01

    Parametric imaging is a compartmental approach that processes nuclear imaging data to estimate the spatial distribution of the kinetic parameters governing tracer flow. The present paper proposes a novel and efficient computational method for parametric imaging which is potentially applicable to several compartmental models of diverse complexity and which is effective in the determination of the parametric maps of all kinetic coefficients. We consider applications to [18 F]-fluorodeoxyglucose positron emission tomography (FDG-PET) data and analyze the two-compartment catenary model describing the standard FDG metabolization by an homogeneous tissue and the three-compartment non-catenary model representing the renal physiology. We show uniqueness theorems for both models. The proposed imaging method starts from the reconstructed FDG-PET images of tracer concentration and preliminarily applies image processing algorithms for noise reduction and image segmentation. The optimization procedure solves pixel-wise the non-linear inverse problem of determining the kinetic parameters from dynamic concentration data through a regularized Gauss-Newton iterative algorithm. The reliability of the method is validated against synthetic data, for the two-compartment system, and experimental real data of murine models, for the renal three-compartment system.

  5. Parametric and non-parametric approach for sensory RATA (Rate-All-That-Apply) method of ledre profile attributes

    Science.gov (United States)

    Hastuti, S.; Harijono; Murtini, E. S.; Fibrianto, K.

    2018-03-01

    This current study is aimed to investigate the use of parametric and non-parametric approach for sensory RATA (Rate-All-That-Apply) method. Ledre as Bojonegoro unique local food product was used as point of interest, in which 319 panelists were involved in the study. The result showed that ledre is characterized as easy-crushed texture, sticky in mouth, stingy sensation and easy to swallow. It has also strong banana flavour with brown in colour. Compared to eggroll and semprong, ledre has more variances in terms of taste as well the roll length. As RATA questionnaire is designed to collect categorical data, non-parametric approach is the common statistical procedure. However, similar results were also obtained as parametric approach, regardless the fact of non-normal distributed data. Thus, it suggests that parametric approach can be applicable for consumer study with large number of respondents, even though it may not satisfy the assumption of ANOVA (Analysis of Variances).

  6. Comparison between linear and non-parametric regression models for genome-enabled prediction in wheat.

    Science.gov (United States)

    Pérez-Rodríguez, Paulino; Gianola, Daniel; González-Camacho, Juan Manuel; Crossa, José; Manès, Yann; Dreisigacker, Susanne

    2012-12-01

    In genome-enabled prediction, parametric, semi-parametric, and non-parametric regression models have been used. This study assessed the predictive ability of linear and non-linear models using dense molecular markers. The linear models were linear on marker effects and included the Bayesian LASSO, Bayesian ridge regression, Bayes A, and Bayes B. The non-linear models (this refers to non-linearity on markers) were reproducing kernel Hilbert space (RKHS) regression, Bayesian regularized neural networks (BRNN), and radial basis function neural networks (RBFNN). These statistical models were compared using 306 elite wheat lines from CIMMYT genotyped with 1717 diversity array technology (DArT) markers and two traits, days to heading (DTH) and grain yield (GY), measured in each of 12 environments. It was found that the three non-linear models had better overall prediction accuracy than the linear regression specification. Results showed a consistent superiority of RKHS and RBFNN over the Bayesian LASSO, Bayesian ridge regression, Bayes A, and Bayes B models.

  7. A parametric model order reduction technique for poroelastic finite element models.

    Science.gov (United States)

    Lappano, Ettore; Polanz, Markus; Desmet, Wim; Mundo, Domenico

    2017-10-01

    This research presents a parametric model order reduction approach for vibro-acoustic problems in the frequency domain of systems containing poroelastic materials (PEM). The method is applied to the Finite Element (FE) discretization of the weak u-p integral formulation based on the Biot-Allard theory and makes use of reduced basis (RB) methods typically employed for parametric problems. The parametric reduction is obtained rewriting the Biot-Allard FE equations for poroelastic materials using an affine representation of the frequency (therefore allowing for RB methods) and projecting the frequency-dependent PEM system on a global reduced order basis generated with the proper orthogonal decomposition instead of standard modal approaches. This has proven to be better suited to describe the nonlinear frequency dependence and the strong coupling introduced by damping. The methodology presented is tested on two three-dimensional systems: in the first experiment, the surface impedance of a PEM layer sample is calculated and compared with results of the literature; in the second, the reduced order model of a multilayer system coupled to an air cavity is assessed and the results are compared to those of the reference FE model.

  8. Dynamic whole-body PET parametric imaging: II. Task-oriented statistical estimation.

    Science.gov (United States)

    Karakatsanis, Nicolas A; Lodge, Martin A; Zhou, Y; Wahl, Richard L; Rahmim, Arman

    2013-10-21

    In the context of oncology, dynamic PET imaging coupled with standard graphical linear analysis has been previously employed to enable quantitative estimation of tracer kinetic parameters of physiological interest at the voxel level, thus, enabling quantitative PET parametric imaging. However, dynamic PET acquisition protocols have been confined to the limited axial field-of-view (~15-20 cm) of a single-bed position and have not been translated to the whole-body clinical imaging domain. On the contrary, standardized uptake value (SUV) PET imaging, considered as the routine approach in clinical oncology, commonly involves multi-bed acquisitions, but is performed statically, thus not allowing for dynamic tracking of the tracer distribution. Here, we pursue a transition to dynamic whole-body PET parametric imaging, by presenting, within a unified framework, clinically feasible multi-bed dynamic PET acquisition protocols and parametric imaging methods. In a companion study, we presented a novel clinically feasible dynamic (4D) multi-bed PET acquisition protocol as well as the concept of whole-body PET parametric imaging employing Patlak ordinary least squares (OLS) regression to estimate the quantitative parameters of tracer uptake rate Ki and total blood distribution volume V. In the present study, we propose an advanced hybrid linear regression framework, driven by Patlak kinetic voxel correlations, to achieve superior trade-off between contrast-to-noise ratio (CNR) and mean squared error (MSE) than provided by OLS for the final Ki parametric images, enabling task-based performance optimization. Overall, whether the observer's task is to detect a tumor or quantitatively assess treatment response, the proposed statistical estimation framework can be adapted to satisfy the specific task performance criteria, by adjusting the Patlak correlation-coefficient (WR) reference value. The multi-bed dynamic acquisition protocol, as optimized in the preceding companion study

  9. Dynamic whole-body PET parametric imaging: II. Task-oriented statistical estimation

    International Nuclear Information System (INIS)

    Karakatsanis, Nicolas A; Lodge, Martin A; Zhou, Y; Wahl, Richard L; Rahmim, Arman

    2013-01-01

    In the context of oncology, dynamic PET imaging coupled with standard graphical linear analysis has been previously employed to enable quantitative estimation of tracer kinetic parameters of physiological interest at the voxel level, thus, enabling quantitative PET parametric imaging. However, dynamic PET acquisition protocols have been confined to the limited axial field-of-view (∼15–20 cm) of a single-bed position and have not been translated to the whole-body clinical imaging domain. On the contrary, standardized uptake value (SUV) PET imaging, considered as the routine approach in clinical oncology, commonly involves multi-bed acquisitions, but is performed statically, thus not allowing for dynamic tracking of the tracer distribution. Here, we pursue a transition to dynamic whole-body PET parametric imaging, by presenting, within a unified framework, clinically feasible multi-bed dynamic PET acquisition protocols and parametric imaging methods. In a companion study, we presented a novel clinically feasible dynamic (4D) multi-bed PET acquisition protocol as well as the concept of whole-body PET parametric imaging employing Patlak ordinary least squares (OLS) regression to estimate the quantitative parameters of tracer uptake rate K i and total blood distribution volume V. In the present study, we propose an advanced hybrid linear regression framework, driven by Patlak kinetic voxel correlations, to achieve superior trade-off between contrast-to-noise ratio (CNR) and mean squared error (MSE) than provided by OLS for the final K i parametric images, enabling task-based performance optimization. Overall, whether the observer's task is to detect a tumor or quantitatively assess treatment response, the proposed statistical estimation framework can be adapted to satisfy the specific task performance criteria, by adjusting the Patlak correlation-coefficient (WR) reference value. The multi-bed dynamic acquisition protocol, as optimized in the preceding companion

  10. Direct reconstruction of cardiac PET kinetic parametric images using a preconditioned conjugate gradient approach.

    Science.gov (United States)

    Rakvongthai, Yothin; Ouyang, Jinsong; Guerin, Bastien; Li, Quanzheng; Alpert, Nathaniel M; El Fakhri, Georges

    2013-10-01

    Our research goal is to develop an algorithm to reconstruct cardiac positron emission tomography (PET) kinetic parametric images directly from sinograms and compare its performance with the conventional indirect approach. Time activity curves of a NCAT phantom were computed according to a one-tissue compartmental kinetic model with realistic kinetic parameters. The sinograms at each time frame were simulated using the activity distribution for the time frame. The authors reconstructed the parametric images directly from the sinograms by optimizing a cost function, which included the Poisson log-likelihood and a spatial regularization terms, using the preconditioned conjugate gradient (PCG) algorithm with the proposed preconditioner. The proposed preconditioner is a diagonal matrix whose diagonal entries are the ratio of the parameter and the sensitivity of the radioactivity associated with parameter. The authors compared the reconstructed parametric images using the direct approach with those reconstructed using the conventional indirect approach. At the same bias, the direct approach yielded significant relative reduction in standard deviation by 12%-29% and 32%-70% for 50 × 10(6) and 10 × 10(6) detected coincidences counts, respectively. Also, the PCG method effectively reached a constant value after only 10 iterations (with numerical convergence achieved after 40-50 iterations), while more than 500 iterations were needed for CG. The authors have developed a novel approach based on the PCG algorithm to directly reconstruct cardiac PET parametric images from sinograms, and yield better estimation of kinetic parameters than the conventional indirect approach, i.e., curve fitting of reconstructed images. The PCG method increases the convergence rate of reconstruction significantly as compared to the conventional CG method.

  11. Soliton Compton Mass from Auto-Parametric Wave-Soliton Coupling

    CERN Document Server

    Binder, B

    2002-01-01

    In this paper a self-excited Rayleigh-type system models the auto-parametric wave-soliton coupling via phase fluctuations. The parameter of dissipative terms determine not only the most likely quantum coupling between solitons and linear waves but also the most likely mass of the solitons. Phase fluctuations are mediated by virtual photons coupling at light-velocity in a permanent Compton scattering process. With a reference to the SI-units and proper scaling relations in length and velocity, the final result shows a highly interesting sequence: the likely soliton Compton mass is about 1.00138 times the neutron and 1.00276 times the proton mass.

  12. Seismological database for Banat seismic region (Romania) - Part 1: The parametric earthquake catalogue

    International Nuclear Information System (INIS)

    Oros, E.; Popa, M.; Moldovan, I. A.

    2008-01-01

    The most comprehensive seismological database for Banat seismic region (Romania) has been achieved. This paper refers to the essential characteristics of the first component of this database, namely the Parametric Earthquakes Catalogue for the Banat Seismic Region (PECBSR). PECBSR comprises 7783 crustal earthquakes (3 ≤ h ≤ 25 km) with 0.4 ≤ M i ≥ 5.6 (M i is M L , M D , M S , M W , Mm and/or mb from compiled sources) occurred in the Banat region and its surroundings between years 1443 and 2006. Different magnitude scales were converted into moment magnitude scale, Mw. The completeness of PECBSR strongly depends on the time. (authors)

  13. Parametric mapping using spectral analysis for 11C-PBR28 PET reveals neuroinflammation in mild cognitive impairment subjects.

    Science.gov (United States)

    Fan, Zhen; Dani, Melanie; Femminella, Grazia D; Wood, Melanie; Calsolaro, Valeria; Veronese, Mattia; Turkheimer, Federico; Gentleman, Steve; Brooks, David J; Hinz, Rainer; Edison, Paul

    2018-07-01

    Neuroinflammation and microglial activation play an important role in amnestic mild cognitive impairment (MCI) and Alzheimer's disease. In this study, we investigated the spatial distribution of neuroinflammation in MCI subjects, using spectral analysis (SA) to generate parametric maps and quantify 11 C-PBR28 PET, and compared these with compartmental and other kinetic models of quantification. Thirteen MCI and nine healthy controls were enrolled in this study. Subjects underwent 11 C-PBR28 PET scans with arterial cannulation. Spectral analysis with an arterial plasma input function was used to generate 11 C-PBR28 parametric maps. These maps were then compared with regional 11 C-PBR28 V T (volume of distribution) using a two-tissue compartment model and Logan graphic analysis. Amyloid load was also assessed with 18 F-Flutemetamol PET. With SA, three component peaks were identified in addition to blood volume. The 11 C-PBR28 impulse response function (IRF) at 90 min produced the lowest coefficient of variation. Single-subject analysis using this IRF demonstrated microglial activation in five out of seven amyloid-positive MCI subjects. IRF parametric maps of 11 C-PBR28 uptake revealed a group-wise significant increase in neuroinflammation in amyloid-positive MCI subjects versus HC in multiple cortical association areas, and particularly in the temporal lobe. Interestingly, compartmental analysis detected group-wise increase in 11 C-PBR28 binding in the thalamus of amyloid-positive MCI subjects, while Logan parametric maps did not perform well. This study demonstrates for the first time that spectral analysis can be used to generate parametric maps of 11 C-PBR28 uptake, and is able to detect microglial activation in amyloid-positive MCI subjects. IRF parametric maps of 11 C-PBR28 uptake allow voxel-wise single-subject analysis and could be used to evaluate microglial activation in individual subjects.

  14. A soft double regularization approach to parametric blind image deconvolution.

    Science.gov (United States)

    Chen, Li; Yap, Kim-Hui

    2005-05-01

    This paper proposes a blind image deconvolution scheme based on soft integration of parametric blur structures. Conventional blind image deconvolution methods encounter a difficult dilemma of either imposing stringent and inflexible preconditions on the problem formulation or experiencing poor restoration results due to lack of information. This paper attempts to address this issue by assessing the relevance of parametric blur information, and incorporating the knowledge into the parametric double regularization (PDR) scheme. The PDR method assumes that the actual blur satisfies up to a certain degree of parametric structure, as there are many well-known parametric blurs in practical applications. Further, it can be tailored flexibly to include other blur types if some prior parametric knowledge of the blur is available. A manifold soft parametric modeling technique is proposed to generate the blur manifolds, and estimate the fuzzy blur structure. The PDR scheme involves the development of the meaningful cost function, the estimation of blur support and structure, and the optimization of the cost function. Experimental results show that it is effective in restoring degraded images under different environments.

  15. Parametric Decay during HHFW on NSTX

    International Nuclear Information System (INIS)

    Wilson, J.R.; Bernabei, S.; Biewer, T.; Diem, S.; Hosea, J.; LeBlanc, B.; Phillips, C.K.; Ryan, P.; Swain, D.W.

    2005-01-01

    High Harmonic Fast Wave (HHFW) heating experiments on NSTX have been observed to be accompanied by significant edge ion heating (T i >> T e ). This heating is found to be anisotropic with T perp > T par . Simultaneously, coherent oscillations have been detected with an edge Langmuir probe. The oscillations are consistent with parametric decay of the incident fast wave (ω > 13ω ci ) into ion Bernstein waves and an unobserved ion-cyclotron quasi-mode. The observation of anisotropic heating is consistent with Bernstein wave damping, and the Bernstein waves should completely damp in the plasma periphery as they propagate toward a cyclotron harmonic resonance. The number of daughter waves is found to increase with rf power, and to increase as the incident wave's toroidal wavelength increases. The frequencies of the daughter wave are separated by the edge ion cyclotron frequency. Theoretical calculations of the threshold for this decay in uniform plasma indicate an extremely small value of incident power should be required to drive the instability. While such decays are commonly observed at lower harmonics in conventional ICRF heating scenarios, they usually do not involve the loss of significant wave power from the pump wave. On NSTX an estimate of the power loss can be found by calculating the minimum power required to support the edge ion heating (presumed to come from the decay Bernstein wave). This calculation indicates at least 20-30% of the incident rf power ends up as decay waves

  16. Parametric Design in Timber Gridshell Tectonics

    Directory of Open Access Journals (Sweden)

    Ismailiyah Al Athas Syarifah

    2018-01-01

    Full Text Available This paper begins with a simple proposition: rather than mimicking the geometric structures found in nature, perhaps the most effective modes of sustainable fabrication can be found throughunderstanding the nature of materials themselves. The material becomes a design parameter through the constraints of fabrication tools, limitations of material size, and most importantly the productivecapacity of material resistance a given material’s capacity and tendencies to take shape, rather than cutting shape out of material. Gridshell structures provide an intriguing case study to pursue this proposition. Not only is there clear precedent in the form finding experiments of frei Otto and the institute for lightweight structures, but also the very nurbs based tools of current design practices developed from the ability of wood to bend. Taking the bent wood spline quite literally, gridshells provide a means that is at once formally expressive, structurally optimized, materially efficient, and quite simply a delight to experience. The the larger motivation of this work anticipates a parametric system linking the intrinsic material values of the gridshell tectonic with extrinsic criteria such as programmatic needs and environmental response. Through an applied case study of gridshells, the play between form and material is tested out through the author’s own experimentation with gridshells and the pedagogical results of two gridshell studios.The goal of this research is to establish a give and take relationship between top down formal emphasis and a bottom-up material influence.

  17. Stability analysis of fuzzy parametric uncertain systems.

    Science.gov (United States)

    Bhiwani, R J; Patre, B M

    2011-10-01

    In this paper, the determination of stability margin, gain and phase margin aspects of fuzzy parametric uncertain systems are dealt. The stability analysis of uncertain linear systems with coefficients described by fuzzy functions is studied. A complexity reduced technique for determining the stability margin for FPUS is proposed. The method suggested is dependent on the order of the characteristic polynomial. In order to find the stability margin of interval polynomials of order less than 5, it is not always necessary to determine and check all four Kharitonov's polynomials. It has been shown that, for determining stability margin of FPUS of order five, four, and three we require only 3, 2, and 1 Kharitonov's polynomials respectively. Only for sixth and higher order polynomials, a complete set of Kharitonov's polynomials are needed to determine the stability margin. Thus for lower order systems, the calculations are reduced to a large extent. This idea has been extended to determine the stability margin of fuzzy interval polynomials. It is also shown that the gain and phase margin of FPUS can be determined analytically without using graphical techniques. Copyright © 2011 ISA. Published by Elsevier Ltd. All rights reserved.

  18. Multidimensional Scaling Visualization Using Parametric Similarity Indices

    Directory of Open Access Journals (Sweden)

    J. A. Tenreiro Machado

    2015-03-01

    Full Text Available In this paper, we apply multidimensional scaling (MDS and parametric similarity indices (PSI in the analysis of complex systems (CS. Each CS is viewed as a dynamical system, exhibiting an output time-series to be interpreted as a manifestation of its behavior. We start by adopting a sliding window to sample the original data into several consecutive time periods. Second, we define a given PSI for tracking pieces of data. We then compare the windows for different values of the parameter, and we generate the corresponding MDS maps of ‘points’. Third, we use Procrustes analysis to linearly transform the MDS charts for maximum superposition and to build a globalMDS map of “shapes”. This final plot captures the time evolution of the phenomena and is sensitive to the PSI adopted. The generalized correlation, theMinkowski distance and four entropy-based indices are tested. The proposed approach is applied to the Dow Jones Industrial Average stock market index and the Europe Brent Spot Price FOB time-series.

  19. Parametric analysis of a magnetized cylindrical plasma

    International Nuclear Information System (INIS)

    Ahedo, Eduardo

    2009-01-01

    The relevant macroscopic model, the spatial structure, and the parametric regimes of a low-pressure plasma confined by a cylinder and an axial magnetic field is discussed for the small-Debye length limit, making use of asymptotic techniques. The plasma response is fully characterized by three-dimensionless parameters, related to the electron gyroradius, and the electron and ion collision mean-free-paths. There are the unmagnetized regime, the main magnetized regime, and, for a low electron-collisionality plasma, an intermediate-magnetization regime. In the magnetized regimes, electron azimuthal inertia is shown to be a dominant phenomenon in part of the quasineutral plasma region and to set up before ion radial inertia. In the main magnetized regime, the plasma structure consists of a bulk diffusive region, a thin layer governed by electron inertia, a thinner sublayer controlled by ion inertia, and the non-neutral Debye sheath. The solution of the main inertial layer yields that the electron azimuthal energy near the wall is larger than the electron thermal energy, making electron resistivity effects non-negligible. The electron Boltzmann relation is satisfied only in the very vicinity of the Debye sheath edge. Ion collisionality effects are irrelevant in the magnetized regime. Simple scaling laws for plasma production and particle and energy fluxes to the wall are derived.

  20. Parametric Analysis of Flexible Logic Control Model

    Directory of Open Access Journals (Sweden)

    Lihua Fu

    2013-01-01

    Full Text Available Based on deep analysis about the essential relation between two input variables of normal two-dimensional fuzzy controller, we used universal combinatorial operation model to describe the logic relationship and gave a flexible logic control method to realize the effective control for complex system. In practical control application, how to determine the general correlation coefficient of flexible logic control model is a problem for further studies. First, the conventional universal combinatorial operation model has been limited in the interval [0,1]. Consequently, this paper studies a kind of universal combinatorial operation model based on the interval [a,b]. And some important theorems are given and proved, which provide a foundation for the flexible logic control method. For dealing reasonably with the complex relations of every factor in complex system, a kind of universal combinatorial operation model with unequal weights is put forward. Then, this paper has carried out the parametric analysis of flexible logic control model. And some research results have been given, which have important directive to determine the values of the general correlation coefficients in practical control application.

  1. A scale invariance criterion for LES parametrizations

    Directory of Open Access Journals (Sweden)

    Urs Schaefer-Rolffs

    2015-01-01

    Full Text Available Turbulent kinetic energy cascades in fluid dynamical systems are usually characterized by scale invariance. However, representations of subgrid scales in large eddy simulations do not necessarily fulfill this constraint. So far, scale invariance has been considered in the context of isotropic, incompressible, and three-dimensional turbulence. In the present paper, the theory is extended to compressible flows that obey the hydrostatic approximation, as well as to corresponding subgrid-scale parametrizations. A criterion is presented to check if the symmetries of the governing equations are correctly translated into the equations used in numerical models. By applying scaling transformations to the model equations, relations between the scaling factors are obtained by demanding that the mathematical structure of the equations does not change.The criterion is validated by recovering the breakdown of scale invariance in the classical Smagorinsky model and confirming scale invariance for the Dynamic Smagorinsky Model. The criterion also shows that the compressible continuity equation is intrinsically scale-invariant. The criterion also proves that a scale-invariant turbulent kinetic energy equation or a scale-invariant equation of motion for a passive tracer is obtained only with a dynamic mixing length. For large-scale atmospheric flows governed by the hydrostatic balance the energy cascade is due to horizontal advection and the vertical length scale exhibits a scaling behaviour that is different from that derived for horizontal length scales.

  2. Supercritical extraction of oleaginous: parametric sensitivity analysis

    Directory of Open Access Journals (Sweden)

    Santos M.M.

    2000-01-01

    Full Text Available The economy has become universal and competitive, thus the industries of vegetable oil extraction must advance in the sense of minimising production costs and, at the same time, generating products that obey more rigorous patterns of quality, including solutions that do not damage the environment. The conventional oilseed processing uses hexane as solvent. However, this solvent is toxic and highly flammable. Thus the search of substitutes for hexane in oleaginous extraction process has increased in the last years. The supercritical carbon dioxide is a potential substitute for hexane, but it is necessary more detailed studies to understand the phenomena taking place in such process. Thus, in this work a diffusive model for semi-continuous (batch for the solids and continuous for the solvent isothermal and isobaric extraction process using supercritical carbon dioxide is presented and submitted to a parametric sensitivity analysis by means of a factorial design in two levels. The model parameters were disturbed and their main effects analysed, so that it is possible to propose strategies for high performance operation.

  3. Improvement of Statistical Decisions under Parametric Uncertainty

    Science.gov (United States)

    Nechval, Nicholas A.; Nechval, Konstantin N.; Purgailis, Maris; Berzins, Gundars; Rozevskis, Uldis

    2011-10-01

    A large number of problems in production planning and scheduling, location, transportation, finance, and engineering design require that decisions be made in the presence of uncertainty. Decision-making under uncertainty is a central problem in statistical inference, and has been formally studied in virtually all approaches to inference. The aim of the present paper is to show how the invariant embedding technique, the idea of which belongs to the authors, may be employed in the particular case of finding the improved statistical decisions under parametric uncertainty. This technique represents a simple and computationally attractive statistical method based on the constructive use of the invariance principle in mathematical statistics. Unlike the Bayesian approach, an invariant embedding technique is independent of the choice of priors. It allows one to eliminate unknown parameters from the problem and to find the best invariant decision rule, which has smaller risk than any of the well-known decision rules. To illustrate the proposed technique, application examples are given.

  4. Tissue types (image)

    Science.gov (United States)

    ... are 4 basic types of tissue: connective tissue, epithelial tissue, muscle tissue, and nervous tissue. Connective tissue supports ... binds them together (bone, blood, and lymph tissues). Epithelial tissue provides a covering (skin, the linings of the ...

  5. Parametric resonance and cooling on an atom chip

    International Nuclear Information System (INIS)

    Yan Bo; Li Xiaolin; Ke Min; Wang Yuzhu

    2008-01-01

    This paper observes the parametric excitation on atom chip by measuring the trap loss when applying a parametric modulation. By modulating the current in chip wires, it modulates not only the trap frequency but also the trap position. It shows that the strongest resonance occurs when the modulation frequency equals to the trap frequency. The resonance amplitude increases exponentially with modulation depth. Because the Z-trap is an anharmonic trap, there exists energy selective excitation which would cause parametric cooling. We confirm this effect by observing the temperature of atom cloud dropping

  6. Parametric Design of Outdoor Broadcasting Studio Based on Schema Theory

    Directory of Open Access Journals (Sweden)

    Zhu Li

    2016-01-01

    Full Text Available This paper mainly demonstrates that the schema is an important way for the architect to cognize architecture form logic. It connects schema to algorithm of parametric design in order to seek the “algorithm schema” generation in parametric design of architecture. Meanwhile, this paper discusses the generative process and methods of the “algorithm schema” in parametric design of architecture by describing a case of outdoor broadcasting studio of Hunan Economic Radio. It also reveals the importance of “algorithm schema” for the cognition and architectural form logic generation.

  7. Standard Reference Tables -

    Data.gov (United States)

    Department of Transportation — The Standard Reference Tables (SRT) provide consistent reference data for the various applications that support Flight Standards Service (AFS) business processes and...

  8. A genetic algorithm-based search for parametric reform alternatives for the Turkish pension system : 2005-2060

    OpenAIRE

    Alparslan, Mustafa Artun

    2005-01-01

    Ankara : The Department of Economics, Bilkent Univ., 2005. Thesis (Master's) -- Bilkent University, 2005. Includes bibliographical references leaves 54-55. In this thesis, we search for parametric reform alternatives so as to achieve a balance in the long term accumulated difference between pension expenditures and revenues of the SSI, the largest pension fund in Turkey, from 2005 to 2060. The projected worker-retiree composition of the pension system is allowed to change al...

  9. An automated four-point scale scoring of segmental wall motion in echocardiography using quantified parametric images

    International Nuclear Information System (INIS)

    Kachenoura, N; Delouche, A; Ruiz Dominguez, C; Frouin, F; Diebold, B; Nardi, O

    2010-01-01

    The aim of this paper is to develop an automated method which operates on echocardiographic dynamic loops for classifying the left ventricular regional wall motion (RWM) in a four-point scale. A non-selected group of 37 patients (2 and 4 chamber views) was studied. Each view was segmented according to the standardized segmentation using three manually positioned anatomical landmarks (the apex and the angles of the mitral annulus). The segmented data were analyzed by two independent experienced echocardiographists and the consensual RWM scores were used as a reference for comparisons. A fast and automatic parametric imaging method was used to compute and display as static color-coded parametric images both temporal and motion information contained in left ventricular dynamic echocardiograms. The amplitude and time parametric images were provided to a cardiologist for visual analysis of RWM and used for RWM quantification. A cross-validation method was applied to the segmental quantitative indices for classifying RWM in a four-point scale. A total of 518 segments were analyzed. Comparison between visual interpretation of parametric images and the reference reading resulted in an absolute agreement (Aa) of 66% and a relative agreement (Ra) of 96% and kappa (κ) coefficient of 0.61. Comparison of the automated RWM scoring against the same reference provided Aa = 64%, Ra = 96% and κ = 0.64 on the validation subset. Finally, linear regression analysis between the global quantitative index and global reference scores as well as ejection fraction resulted in correlations of 0.85 and 0.79. A new automated four-point scale scoring of RWM was developed and tested in a non-selected database. Its comparison against a consensual visual reading of dynamic echocardiograms showed its ability to classify RWM abnormalities.

  10. Photon Entanglement Through Brain Tissue.

    Science.gov (United States)

    Shi, Lingyan; Galvez, Enrique J; Alfano, Robert R

    2016-12-20

    Photon entanglement, the cornerstone of quantum correlations, provides a level of coherence that is not present in classical correlations. Harnessing it by study of its passage through organic matter may offer new possibilities for medical diagnosis technique. In this work, we study the preservation of photon entanglement in polarization, created by spontaneous parametric down-conversion, after one entangled photon propagates through multiphoton-scattering brain tissue slices with different thickness. The Tangle-Entropy (TS) plots show the strong preservation of entanglement of photons propagating in brain tissue. By spatially filtering the ballistic scattering of an entangled photon, we find that its polarization entanglement is preserved and non-locally correlated with its twin in the TS plots. The degree of entanglement correlates better with structure and water content than with sample thickness.

  11. Incorporating Oxygen-Enhanced MRI into Multi-Parametric Assessment of Human Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Heling Zhou

    2017-08-01

    Full Text Available Hypoxia is associated with prostate tumor aggressiveness, local recurrence, and biochemical failure. Magnetic resonance imaging (MRI offers insight into tumor pathophysiology and recent reports have related transverse relaxation rate (R2* and longitudinal relaxation rate (R1 measurements to tumor hypoxia. We have investigated the inclusion of oxygen-enhanced MRI for multi-parametric evaluation of tumor malignancy. Multi-parametric MRI sequences at 3 Tesla were evaluated in 10 patients to investigate hypoxia in prostate cancer prior to radical prostatectomy. Blood oxygen level dependent (BOLD, tissue oxygen level dependent (TOLD, dynamic contrast enhanced (DCE, and diffusion weighted imaging MRI were intercorrelated and compared with the Gleason score. The apparent diffusion coefficient (ADC was significantly lower in tumor than normal prostate. Baseline R2* (BOLD-contrast was significantly higher in tumor than normal prostate. Upon the oxygen breathing challenge, R2* decreased significantly in the tumor tissue, suggesting improved vascular oxygenation, however changes in R1 were minimal. R2* of contralateral normal prostate decreased in most cases upon oxygen challenge, although the differences were not significant. Moderate correlation was found between ADC and Gleason score. ADC and R2* were correlated and trends were found between Gleason score and R2*, as well as maximum-intensity-projection and area-under-the-curve calculated from DCE. Tumor ADC and R2* have been associated with tumor hypoxia, and thus the correlations are of particular interest. A multi-parametric approach including oxygen-enhanced MRI is feasible and promises further insights into the pathophysiological information of tumor microenvironment.

  12. Design and Parametric Study of the Magnetic Sensor for Position Detection in Linear Motor Based on Nonlinear Parametric model order reduction.

    Science.gov (United States)

    Paul, Sarbajit; Chang, Junghwan

    2017-07-01

    This paper presents a design approach for a magnetic sensor module to detect mover position using the proper orthogonal decomposition-dynamic mode decomposition (POD-DMD)-based nonlinear parametric model order reduction (PMOR). The parameterization of the sensor module is achieved by using the multipolar moment matching method. Several geometric variables of the sensor module are considered while developing the parametric study. The operation of the sensor module is based on the principle of the airgap flux density distribution detection by the Hall Effect IC. Therefore, the design objective is to achieve a peak flux density (PFD) greater than 0.1 T and total harmonic distortion (THD) less than 3%. To fulfill the constraint conditions, the specifications for the sensor module is achieved by using POD-DMD based reduced model. The POD-DMD based reduced model provides a platform to analyze the high number of design models very fast, with less computational burden. Finally, with the final specifications, the experimental prototype is designed and tested. Two different modes, 90° and 120° modes respectively are used to obtain the position information of the linear motor mover. The position information thus obtained are compared with that of the linear scale data, used as a reference signal. The position information obtained using the 120° mode has a standard deviation of 0.10 mm from the reference linear scale signal, whereas the 90° mode position signal shows a deviation of 0.23 mm from the reference. The deviation in the output arises due to the mechanical tolerances introduced into the specification during the manufacturing process. This provides a scope for coupling the reliability based design optimization in the design process as a future extension.

  13. Cardiac-gated parametric images from 82 Rb PET from dynamic frames and direct 4D reconstruction.

    Science.gov (United States)

    Germino, Mary; Carson, Richard E

    2018-02-01

    Cardiac perfusion PET data can be reconstructed as a dynamic sequence and kinetic modeling performed to quantify myocardial blood flow, or reconstructed as static gated images to quantify function. Parametric images from dynamic PET are conventionally not gated, to allow use of all events with lower noise. An alternative method for dynamic PET is to incorporate the kinetic model into the reconstruction algorithm itself, bypassing the generation of a time series of emission images and directly producing parametric images. So-called "direct reconstruction" can produce parametric images with lower noise than the conventional method because the noise distribution is more easily modeled in projection space than in image space. In this work, we develop direct reconstruction of cardiac-gated parametric images for 82 Rb PET with an extension of the Parametric Motion compensation OSEM List mode Algorithm for Resolution-recovery reconstruction for the one tissue model (PMOLAR-1T). PMOLAR-1T was extended to accommodate model terms to account for spillover from the left and right ventricles into the myocardium. The algorithm was evaluated on a 4D simulated 82 Rb dataset, including a perfusion defect, as well as a human 82 Rb list mode acquisition. The simulated list mode was subsampled into replicates, each with counts comparable to one gate of a gated acquisition. Parametric images were produced by the indirect (separate reconstructions and modeling) and direct methods for each of eight low-count and eight normal-count replicates of the simulated data, and each of eight cardiac gates for the human data. For the direct method, two initialization schemes were tested: uniform initialization, and initialization with the filtered iteration 1 result of the indirect method. For the human dataset, event-by-event respiratory motion compensation was included. The indirect and direct methods were compared for the simulated dataset in terms of bias and coefficient of variation as a

  14. Parametric imaging of the rate constant K[sub i] using 18Fluoro-L-dopa positron emission tomography in progressive supranuclear palsy

    Energy Technology Data Exchange (ETDEWEB)

    Cordes, M. (Neurodegenerative Disorders Centre, Univ. Hospital, Univ. of British Columbia, Vancouver, BC (Canada) Strahlenklinik und Poliklinik, Universitaetsklinikum Rudolf-Virchow, Berlin (Germany)); Snow, B.J. (Neurodegenerative Disorders Centre, Univ. Hospital, Univ. of British Columbia, Vancouver, BC (Canada)); Morrison, S. (TRIUMF, Univ. of British Columbia, Vancouver, BC (Canada)); Sossi, V. (TRIUMF, Univ. of British Columbia, Vancouver, BC (Canada)); Ruth, T.J. (TRIUMF, Univ. of British Columbia, Vancouver, BC (Canada)); Calne, D.B. (Neurodegenerative Disorders Centre, Univ. Hospital, Univ. of British Columbia, Vancouver, BC (Canada))

    1993-01-01

    Positron emission tomography (PET) studies using 18F-L-dopa were carried out in 9 patients with supranuclear palsy and 13 controls. For quantification of PET data a rate constant K[sub i] was calculated for the radiotracer using a graphical method. Corrections for nonspecific activity were performed in both arterial plasma and brain tissue. The purpose of this study was to test the hypothesis that parametric images of the rate constant K mapping can be obtained on a pixel-by-pixel basis using an appropriate mathematical algorithm. K[sub i] values from these parametric images and the graphical approach were compared. Both correlated closely, with y=0.013+0.947[sup *]x, r=0.992 and y=-0.052+1.048[sup *]x, r=0.965 in patients and controls, respectively. Contrast measurements were also performed and showed a striking increase in contrast on parametric images. K mapping offers several advantages over the graphical approach, since parametric images are time-independent, i.e. one image represents the quantitative result of the study. In addition, parmetric images of the rate constant are normalized to arterial plasma radioactivity and corrected for tissue metabolites. Thus, parametric images of K[sub i] in different individuals can be compared directly without further processing in order to assess the nigrostriatal integrity. (orig.)

  15. Hamiltonian constraint in polymer parametrized field theory

    International Nuclear Information System (INIS)

    Laddha, Alok; Varadarajan, Madhavan

    2011-01-01

    Recently, a generally covariant reformulation of two-dimensional flat spacetime free scalar field theory known as parametrized field theory was quantized using loop quantum gravity (LQG) type ''polymer'' representations. Physical states were constructed, without intermediate regularization structures, by averaging over the group of gauge transformations generated by the constraints, the constraint algebra being a Lie algebra. We consider classically equivalent combinations of these constraints corresponding to a diffeomorphism and a Hamiltonian constraint, which, as in gravity, define a Dirac algebra. Our treatment of the quantum constraints parallels that of LQG and obtains the following results, expected to be of use in the construction of the quantum dynamics of LQG: (i) the (triangulated) Hamiltonian constraint acts only on vertices, its construction involves some of the same ambiguities as in LQG and its action on diffeomorphism invariant states admits a continuum limit, (ii) if the regulating holonomies are in representations tailored to the edge labels of the state, all previously obtained physical states lie in the kernel of the Hamiltonian constraint, (iii) the commutator of two (density weight 1) Hamiltonian constraints as well as the operator correspondent of their classical Poisson bracket converge to zero in the continuum limit defined by diffeomorphism invariant states, and vanish on the Lewandowski-Marolf habitat, (iv) the rescaled density 2 Hamiltonian constraints and their commutator are ill-defined on the Lewandowski-Marolf habitat despite the well-definedness of the operator correspondent of their classical Poisson bracket there, (v) there is a new habitat which supports a nontrivial representation of the Poisson-Lie algebra of density 2 constraints.

  16. Parametric decay instabilities in ECR heated plasmas

    International Nuclear Information System (INIS)

    Porkolab, M.

    1982-01-01

    The possibility of parametric excitation of electron Bernstein waves and low frequency ion oscillations during ECR heating at omega/sub o/ approx. = l omega/sub ce/, l = 1,2 is examined. In particular, the thresholds for such instabilities are calculated. It is found that Bernstein waves and lower hybrid quasi-modes have relatively low homogeneous where T/sub e/ approx. = T/sub i/. Thus, these processes may lead to nonlinear absorption and/or scattering of the incident pump wave. The resulting Bernstein waves may lead to either more effective heating (especially during the start-up phase) or to loss of microwave energy if the decay waves propagate out of the system before their energy is absorbed by particles. While at omega/sub o/ = omega/sub UH/ the threshold is reduced due to the WKB enhancement of the pump wave, (and this instability may be important in tokamaks) in EBT's and tandem mirrors the instability at omega /sub o/ greater than or equal to 2 omega/sub ce/ may be important. The instability may persist even if omega > 2 omega/sub ce/ and this may be the case during finite beta depression of the magnetic field in which case the decay waves may be trapped in the local magnetic well so that convective losses are minimized. The excited fluctuations may lead to additional scattering of the ring electrons and the incident microwave fields. Application of these calculations to ECR heating of tokamaks, tandem mirrors, and EBT's will be examined

  17. Parametric tomography of the cardiac blood pool

    International Nuclear Information System (INIS)

    Meyer, M.; Schwartz, K.D.

    1990-01-01

    In nuclear cardiology image processing is performed usually in 3 of 4 dimensions. ECG-gated SPECT (GSPECT) would make it possible to obtain all 4 dimensions of space and time during one examination, but its duration as well as radiation dose is limited resulting in a low signal-to-noise ratio. Sensitive feature extractions from the amount of data are necessary, e.g. Fourier filtering or extracting isovolumetric intervals. The relatively large amount of calculations and storage requirements often handicaps tomographic ventriculography because a high number of sections have to be processed and the temporal resolution is limited. A new list-mode oriented tomographic algorithm demands less storage and fewer calculations: The Fourier coefficient extraction and the filtered back projection, both of which are linear operations, could be interchanged in the case of thoracic SPECT. The feature extraction algorithm process internal list-mode heart cycles for discrimination of invalid cycles, for end-diastolic and end-systolic synthesis as well as for Fourier analysis of the first harmonic in 10 ms steps. Reconstruction operations are applied also to modified distribution matrices of Fourier coefficients. By only processing 4 spatial matrix sequences (end-diastolic and end-systolic images, amplitude and phase values) parametric tomography becomes practicable and could be also performed by a minicomputer with 64 KByte memory in addition to the possibilities of the planar left ventricular gated imaging. If there are 3 or more processors available a complete feature extraction on-the-fly will be possible. The numerical algorithms were tested with respect to stable reconstructions by phantoms. First results of a patient examination are used to explore effective display techniques, and preliminary modes are demonstrated. It is the purpose of this study to obtain additional information about the gated planar cardiac blood pool imaging in the field of SPECT. (author)

  18. Parametric study of roof diaphragm stiffness requirements

    International Nuclear Information System (INIS)

    Jones, W.D.; Tenbus, M.A.

    1991-01-01

    A common assumption made in performing a dynamic seismic analysis for a building is that the roof/floor system is open-quotes rigidclose quotes. This assumption would appear to be reasonable for many of the structures found in nuclear power plants, since many of these structures are constructed of heavily reinforced concrete having floor/roof slabs at least two feet in thickness, and meet the code requirements for structural detailing for seismic design. The roofs of many Department of Energy (DOE) buildings at the Oak Ridge Y-12 Plant in Oak Ridge, Tennessee, have roofs constructed of either metal, precast concrete or gypsum plank deck overlaid with rigid insulation, tar and gravel. In performing natural phenomena hazard assessments for one such facility, it was assumed that the existing roof performed first as a flexible diaphragm (zero stiffness) and then, rigid (infinitely stiff). For the flexible diaphragm model it was determined that the building began to experience significant damage around 0.09 g's. For the rigid diaphragm model it was determined that no significant damage was observed below 0.20 g's. A Conceptual Design Report has been prepared for upgrading/replacing the roof of this building. The question that needed to be answered here was, open-quotes How stiff should the new roof diaphragm be in order to satisfy the rigid diaphragm assumption and, yet, be cost effective?close quotes. This paper presents a parametric study of a very simple structural system to show that the design of roof diaphragms needs to consider both strength and stiffness (frequency) requirements. This paper shows how the stiffness of a roof system affects the seismically induced loads in the lateral, vertical load resisting elements of a building and provides guidance in determining how open-quotes rigidclose quotes a roof system should be in order to accomplish a cost effective design

  19. Current-driven parametric resonance in magnetic multilayers

    International Nuclear Information System (INIS)

    Wang, C; Seinige, H; Tsoi, M

    2013-01-01

    Current-induced parametric excitations were observed in point-contact spin-valve nanodevices. Point contacts were used to inject high densities of direct and microwave currents into spin valves, thus producing oscillating spin-transfer and Oersted-field torques on magnetic moments. The resulting magnetodynamics were observed electrically by measuring rectified voltage signals across the contact. In addition to the spin-torque-driven ferromagnetic resonance we observe doubled-frequency signals which correspond to the parametric excitation of magnetic moments. Numerical simulations suggest that while both spin-transfer torque and ac Oersted field contribute to the parametrically excited dynamics, the ac spin torque dominates, and dc spin torque can switch it on and off. The dc bias dependence of the parametric resonance signal enabled the mapping of instability regions characterizing the nonlinearity of the oscillation. (paper)

  20. Determinant of flexible Parametric Estimation of Mixture Cure ...

    African Journals Online (AJOL)

    PROF. OLIVER OSUAGWA

    2015-12-01

    Dec 1, 2015 ... Suitability of four parametric mixture cure models were considered namely; Log .... regression analysis which relies on the ... The parameter of mixture cure fraction model was ..... Stochastic Models of Tumor Latency and Their.

  1. Semi-parametrical NAA method for paper analysis

    International Nuclear Information System (INIS)

    Medeiros, Ilca M.M.A.; Zamboni, Cibele B.; Cruz, Manuel T.F. da; Morel, Jose C.O.; Park, Song W.

    2007-01-01

    The semi-parametric Neutron Activation Analysis technique, using Au as flux monitor, was applied to determine element concentrations in white paper, usually commercialized, aiming to check the quality control of its production in industrial process. (author)

  2. Interplay between parametric instabilities in fusion - relevant laser plasmas

    International Nuclear Information System (INIS)

    Huller, St.

    2003-01-01

    The control of parametric instabilities plays an important role in laser fusion. They are driven by the incident laser beams in the underdense plasma surrounding a fusion capsule and hinder the absorption process of incident laser light which is necessary to heat the fusion target. Due to its high intensity and power, the laser light modifies the plasma density dynamically, such that two or more parametric instabilities compete, in particular stimulated Brillouin scattering and the filamentation instability. The complicated interplay between these parametric instabilities is studied in detail by developing an adequate model accompanied by numerical simulations with multidimensional codes. The model is applied to generic and to smoothed laser beams, which are necessary to limit parametric instabilities, with parameters close to experimental conditions. (author)

  3. Parametric trapping of electromagnetic waves in an inhomogeneous plasma

    International Nuclear Information System (INIS)

    Silin, V.P.; Starodub, A.N.

    1977-01-01

    Considered is parametric instability in an inhomogeneous plasma at which a pumping wave is transformed to an electromagnetic wave and aperiodically in-time-growing disturbances. It is shown that after achievement of some boundary pumping value by electric field intensity an absolute parametric instability evolution becomes possible. In-time growing plasma disturbances are localized near electric field extremums of a pumping wave. Such localization areas are small as compared to characteristic size of pumping inhomogeneity in a plasma. The secondary electromagnetic waves stay within the localization areas and, therefore, are not scattered by a plasma. As following from this it has been established, that due to parametric instability electromagnetic radiation trapping by a plasma occurs. Such a trapping is considerably connected with a spatial structure of a pumping field and it cannot arise within the field of a running wave in the theoretical model considered. However parametric trapping turns out to be possible even with very small reflection coefficients

  4. Evaluating forest management policies by parametric linear programing

    Science.gov (United States)

    Daniel I. Navon; Richard J. McConnen

    1967-01-01

    An analytical and simulation technique, parametric linear programing explores alternative conditions and devises an optimal management plan for each condition. Its application in solving policy-decision problems in the management of forest lands is illustrated in an example.

  5. The RECENT code with the Reich-Moore parametrization

    International Nuclear Information System (INIS)

    Melnikoff, M.; Chalhoub, E.S.; Carlson, B.V.

    1985-01-01

    The program RECENT, which reconstructs neutron cross sections from resonance parameters given in the ENDF/B format, was modified in order to include in its structure the Reich-Moore parametrization. (Author) [pt

  6. Parametric optimization of CNC end milling using entropy ...

    African Journals Online (AJOL)

    Parametric optimization of CNC end milling using entropy measurement technique combined with grey-Taguchi method. ... International Journal of Engineering, Science and Technology ... Keywords: CNC end milling, surface finish, material removal rate (MRR), entropy measurement technique, Taguchi method ...

  7. On the unlimited gain of a nonlinear parametric amplifier

    DEFF Research Database (Denmark)

    Sorokin, Vladislav

    2014-01-01

    The present paper is concerned with analysis of the response of a nonlinear parametric amplifier in abroad range of system parameters, particularly beyond resonance. Such analysis is of particular interestfor micro- and nanosystems, since many small-scale parametric amplifiers exhibit a distinctly...... nonlinearbehavior when amplitude of their response is sufficiently large. The modified method of direct separa-tion of motions is employed to study the considered system. As the result it is obtained that steady-stateamplitude of the nonlinear parametric amplifier response can reach large values in the case...... of arbitrarilysmall amplitude of external excitation, so that the amplifier gain tends to infinity. Very large amplifiergain can be achieved in a broad range of system parameters, in particular when the amplitude of para-metric excitation is comparatively small. The obtained results clearly demonstrate that very...

  8. Comparing parametric and nonparametric regression methods for panel data

    DEFF Research Database (Denmark)

    Czekaj, Tomasz Gerard; Henningsen, Arne

    We investigate and compare the suitability of parametric and non-parametric stochastic regression methods for analysing production technologies and the optimal firm size. Our theoretical analysis shows that the most commonly used functional forms in empirical production analysis, Cobb......-Douglas and Translog, are unsuitable for analysing the optimal firm size. We show that the Translog functional form implies an implausible linear relationship between the (logarithmic) firm size and the elasticity of scale, where the slope is artificially related to the substitutability between the inputs....... The practical applicability of the parametric and non-parametric regression methods is scrutinised and compared by an empirical example: we analyse the production technology and investigate the optimal size of Polish crop farms based on a firm-level balanced panel data set. A nonparametric specification test...

  9. Scaling of plasma turbulence resulting from parametric instabilities

    International Nuclear Information System (INIS)

    Ott, E.

    1976-01-01

    Dimensional analysis is used to obtain results on the turbulent state resulting from parametric instabilities of an initially cold plasma. The results include the possibility of an applied magnetic field, multiple ion species, and arbitrary dimensionality

  10. Using non-parametric methods in econometric production analysis

    DEFF Research Database (Denmark)

    Czekaj, Tomasz Gerard; Henningsen, Arne

    2012-01-01

    by investigating the relationship between the elasticity of scale and the farm size. We use a balanced panel data set of 371~specialised crop farms for the years 2004-2007. A non-parametric specification test shows that neither the Cobb-Douglas function nor the Translog function are consistent with the "true......Econometric estimation of production functions is one of the most common methods in applied economic production analysis. These studies usually apply parametric estimation techniques, which obligate the researcher to specify a functional form of the production function of which the Cobb...... parameter estimates, but also in biased measures which are derived from the parameters, such as elasticities. Therefore, we propose to use non-parametric econometric methods. First, these can be applied to verify the functional form used in parametric production analysis. Second, they can be directly used...

  11. Parametric roll resonance monitoring using signal-based detection

    DEFF Research Database (Denmark)

    Galeazzi, Roberto; Blanke, Mogens; Falkenberg, Thomas

    2015-01-01

    Extreme roll motion of ships can be caused by several phenomena, one of which is parametric roll resonance. Several incidents occurred unexpectedly around the millennium and caused vast fiscal losses on large container vessels. The phenomenon is now well understood and some consider parametric roll...... algorithms in real conditions, and to evaluate the frequency of parametric roll events on the selected vessels. Detection performance is scrutinised through the validation of the detected events using owners’ standard methods, and supported by available wave radar data. Further, a bivariate statistical...... analysis of the outcome of the signal-based detectors is performed to assess the real life false alarm probability. It is shown that detection robustness and very low false warning rates are obtained. The study concludes that small parametric roll events are occurring, and that the proposed signal...

  12. Prediction of Parametric Roll Resonance by Multilayer Perceptron Neural Network

    DEFF Research Database (Denmark)

    Míguez González, M; López Peña, F.; Díaz Casás, V.

    2011-01-01

    Parametric roll resonance is a ship stability related phenomenon that generates sudden large amplitude oscillations up to 30-40 degrees of roll. This can cause severe damage, and it can put the crew in serious danger. The need for a parametric rolling real time prediction system has been acknowle......Parametric roll resonance is a ship stability related phenomenon that generates sudden large amplitude oscillations up to 30-40 degrees of roll. This can cause severe damage, and it can put the crew in serious danger. The need for a parametric rolling real time prediction system has been...... acknowledged in the last few years. This work proposes a prediction system based on a multilayer perceptron (MP) neural network. The training and testing of the MP network is accomplished by feeding it with simulated data of a three degrees-of-freedom nonlinear model of a fishing vessel. The neural network...

  13. Involute Spur Gear Template Development by Parametric Technique ...

    African Journals Online (AJOL)

    Nekky Umera

    cylindrical coordinate systems to create the involute curve profile. Since spur gear ... Template gear development using parametric method means that the dimensions control the ... and rapid prototyping of interlocking gears. Excel is a common ...

  14. Parametric Portfolio Selection: Evaluating and Comparing to Markowitz Portfolios

    Directory of Open Access Journals (Sweden)

    Marcelo C. Medeiros

    2014-10-01

    Full Text Available In this paper we exploit the parametric portfolio optimization in the Brazilian market. Our data consists of monthly returns of 306 Brazilian stocks in the period between 2001 and 2013. We tested the model both in and out of sample and compared the results with the value and equal weighted portfolios and with a Markowitz based portfolio. We performed statistical inference in the parametric optimization using bootstrap techniques in order to build the parameters empirical distributions. Our results showed that the parametric optimization is a very efficient technique out of sample. It consistently showed superior results when compared with the VW, EW and Markowitz portfolios even when transaction costs were included. Finally, we consider the parametric approach to be very flexible to the inclusion of constraints in weights, transaction costs and listing and delisting of stocks.

  15. Housing price prediction: parametric versus semi-parametric spatial hedonic models

    Science.gov (United States)

    Montero, José-María; Mínguez, Román; Fernández-Avilés, Gema

    2018-01-01

    House price prediction is a hot topic in the economic literature. House price prediction has traditionally been approached using a-spatial linear (or intrinsically linear) hedonic models. It has been shown, however, that spatial effects are inherent in house pricing. This article considers parametric and semi-parametric spatial hedonic model variants that account for spatial autocorrelation, spatial heterogeneity and (smooth and nonparametrically specified) nonlinearities using penalized splines methodology. The models are represented as a mixed model that allow for the estimation of the smoothing parameters along with the other parameters of the model. To assess the out-of-sample performance of the models, the paper uses a database containing the price and characteristics of 10,512 homes in Madrid, Spain (Q1 2010). The results obtained suggest that the nonlinear models accounting for spatial heterogeneity and flexible nonlinear relationships between some of the individual or areal characteristics of the houses and their prices are the best strategies for house price prediction.

  16. The evalution of reproduction parametres in chosen herd of sheep

    OpenAIRE

    BENEŠOVÁ, Kristýna

    2009-01-01

    It has been observed the breed herd of Texel sheep in the foothills area of Orlické mountains in the year 2005-2008. The base of herd was consisted of 374 ewes, 575 lambs and 6 rams in total. These parametres of reproduction - conception, fertility, rearing, empty ewes, abortions, lambing, stillborn, death after born, were monitored at ewes. For the parametres of reproduction at ewes were found significant effects of ewe´s age and ram´s line.

  17. Relativistic parametric instabilities in extended extragalactic radio sources

    Energy Technology Data Exchange (ETDEWEB)

    Ferrari, A [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Trussoni, E; Zaninetti, L

    1978-01-01

    A general discussion is presented of parametric instabilities of electromagnetic waves in cold plasmas. Previous results for f = eE/msub(e)c..omega../sub 0/ >> 1 and << 1 are extended and the intermediate range f approximately 1, which could be relevant in some astrophysical applications, is analysed by numerical techniques. In the final section a model for particle acceleration and radiation emission by turbulent plasma modes excited in extended radiosources by parametric absorption of strong electromagnetic waves is tentatively discussed.

  18. Two-parametric PT-symmetric quartic family

    International Nuclear Information System (INIS)

    Eremenko, Alexandre; Gabrielov, Andrei

    2012-01-01

    We describe a parametrization of the real spectral locus of the two-parametric family of PT-symmetric quartic oscillators. For this family, we find a parameter region where all eigenvalues are real, extending the results of Dorey et al (2007 J. Phys. A: Math Theor. 40 R205–83) and Shin (2005 J. Phys. A: Math. Gen. 38 6147–66; 2002 Commun. Math. Phys. 229 543–64). (paper)

  19. Pulse Distortion in Saturated Fiber Optical Parametric Chirped Pulse Amplification

    DEFF Research Database (Denmark)

    Lali-Dastjerdi, Zohreh; Da Ros, Francesco; Rottwitt, Karsten

    2012-01-01

    Fiber optical parametric chirped pulse amplification is experimentally compared for different chirped pulses in the picosecond regime. The amplified chirped pulses show distortion appearing as pedestals after recompression when the amplifier is operated in saturation.......Fiber optical parametric chirped pulse amplification is experimentally compared for different chirped pulses in the picosecond regime. The amplified chirped pulses show distortion appearing as pedestals after recompression when the amplifier is operated in saturation....

  20. Bayesian non- and semi-parametric methods and applications

    CERN Document Server

    Rossi, Peter

    2014-01-01

    This book reviews and develops Bayesian non-parametric and semi-parametric methods for applications in microeconometrics and quantitative marketing. Most econometric models used in microeconomics and marketing applications involve arbitrary distributional assumptions. As more data becomes available, a natural desire to provide methods that relax these assumptions arises. Peter Rossi advocates a Bayesian approach in which specific distributional assumptions are replaced with more flexible distributions based on mixtures of normals. The Bayesian approach can use either a large but fixed number

  1. Excess quantum noise in optical parametric chirped-pulse amplification

    OpenAIRE

    Manzoni, C.; Moses, J.; Kärtner, F. X.; Cerullo, G.

    2011-01-01

    Noise evolution in an optical parametric chirped-pulse amplifier (OPCPA) differs essentially from that of an optical parametric or a conventional laser amplifier, in that an incoherent pedestal is produced by superfluorescence that can overwhelm the signal under strong saturation. Using a model for the nonlinear dynamics consistent with quantum mechanics, we numerically study the evolution of excess noise in an OPCPA. The observed dynamics explain the macroscopic characteristics seen previous...

  2. Global optimization of silicon nanowires for efficient parametric processes

    DEFF Research Database (Denmark)

    Vukovic, Dragana; Xu, Jing; Mørk, Jesper

    2013-01-01

    We present a global optimization of silicon nanowires for parametric single-pump mixing. For the first time, the effect of surface roughness-induced loss is included in the analysis, significantly influencing the optimum waveguide dimensions.......We present a global optimization of silicon nanowires for parametric single-pump mixing. For the first time, the effect of surface roughness-induced loss is included in the analysis, significantly influencing the optimum waveguide dimensions....

  3. Applying Parametric Fault Detection to a Mechanical System

    DEFF Research Database (Denmark)

    Felício, P.; Stoustrup, Jakob; Niemann, H.

    2002-01-01

    A way of doing parametric fault detection is described. It is based on the representation of parameter changes as linear fractional transformations (lfts). We describe a model with parametric uncertainty. Then a stabilizing controller is chosen and its robustness properties are studied via mu. Th....... The parameter changes (faults) are estimated based on estimates of the fictitious signals that enter the delta block in the lft. These signal estimators are designed by H-infinity techniques. The chosen example is an inverted pendulum....

  4. Tissue Classification

    DEFF Research Database (Denmark)

    Van Leemput, Koen; Puonti, Oula

    2015-01-01

    Computational methods for automatically segmenting magnetic resonance images of the brain have seen tremendous advances in recent years. So-called tissue classification techniques, aimed at extracting the three main brain tissue classes (white matter, gray matter, and cerebrospinal fluid), are now...... well established. In their simplest form, these methods classify voxels independently based on their intensity alone, although much more sophisticated models are typically used in practice. This article aims to give an overview of often-used computational techniques for brain tissue classification...

  5. Parametric and non-parametric masking of randomness in sequence alignments can be improved and leads to better resolved trees

    Directory of Open Access Journals (Sweden)

    von Reumont Björn M

    2010-03-01

    Full Text Available Abstract Background Methods of alignment masking, which refers to the technique of excluding alignment blocks prior to tree reconstructions, have been successful in improving the signal-to-noise ratio in sequence alignments. However, the lack of formally well defined methods to identify randomness in sequence alignments has prevented a routine application of alignment masking. In this study, we compared the effects on tree reconstructions of the most commonly used profiling method (GBLOCKS which uses a predefined set of rules in combination with alignment masking, with a new profiling approach (ALISCORE based on Monte Carlo resampling within a sliding window, using different data sets and alignment methods. While the GBLOCKS approach excludes variable sections above a certain threshold which choice is left arbitrary, the ALISCORE algorithm is free of a priori rating of parameter space and therefore more objective. Results ALISCORE was successfully extended to amino acids using a proportional model and empirical substitution matrices to score randomness in multiple sequence alignments. A complex bootstrap resampling leads to an even distribution of scores of randomly similar sequences to assess randomness of the observed sequence similarity. Testing performance on real data, both masking methods, GBLOCKS and ALISCORE, helped to improve tree resolution. The sliding window approach was less sensitive to different alignments of identical data sets and performed equally well on all data sets. Concurrently, ALISCORE is capable of dealing with different substitution patterns and heterogeneous base composition. ALISCORE and the most relaxed GBLOCKS gap parameter setting performed best on all data sets. Correspondingly, Neighbor-Net analyses showed the most decrease in conflict. Conclusions Alignment masking improves signal-to-noise ratio in multiple sequence alignments prior to phylogenetic reconstruction. Given the robust performance of alignment

  6. Soft tissue modelling with conical springs.

    Science.gov (United States)

    Omar, Nadzeri; Zhong, Yongmin; Jazar, Reza N; Subic, Aleksandar; Smith, Julian; Shirinzadeh, Bijan

    2015-01-01

    This paper presents a new method for real-time modelling soft tissue deformation. It improves the traditional mass-spring model with conical springs to deal with nonlinear mechanical behaviours of soft tissues. A conical spring model is developed to predict soft tissue deformation with reference to deformation patterns. The model parameters are formulated according to tissue deformation patterns and the nonlinear behaviours of soft tissues are modelled with the stiffness variation of conical spring. Experimental results show that the proposed method can describe different tissue deformation patterns using one single equation and also exhibit the typical mechanical behaviours of soft tissues.

  7. Design Automation Using Script Languages. High-Level CAD Templates in Non-Parametric Programs

    Science.gov (United States)

    Moreno, R.; Bazán, A. M.

    2017-10-01

    The main purpose of this work is to study the advantages offered by the application of traditional techniques of technical drawing in processes for automation of the design, with non-parametric CAD programs, provided with scripting languages. Given that an example drawing can be solved with traditional step-by-step detailed procedures, is possible to do the same with CAD applications and to generalize it later, incorporating references. In today’s modern CAD applications, there are striking absences of solutions for building engineering: oblique projections (military and cavalier), 3D modelling of complex stairs, roofs, furniture, and so on. The use of geometric references (using variables in script languages) and their incorporation into high-level CAD templates allows the automation of processes. Instead of repeatedly creating similar designs or modifying their data, users should be able to use these templates to generate future variations of the same design. This paper presents the automation process of several complex drawing examples based on CAD script files aided with parametric geometry calculation tools. The proposed method allows us to solve complex geometry designs not currently incorporated in the current CAD applications and to subsequently create other new derivatives without user intervention. Automation in the generation of complex designs not only saves time but also increases the quality of the presentations and reduces the possibility of human errors.

  8. Parametric assessments on hydrogenic species transport in CVD-diamond vacuum windows used in ITER ECRH

    Energy Technology Data Exchange (ETDEWEB)

    Moreno, C.; Sedano, L.A.; Fernandez, A. [EURATOM-CIEMAT Association, Madrid (Spain)

    2007-07-01

    Insulators used as H and CD and Diagnostic vacuum windows (VW) in ITER may become modified by surface intake and bulk transport of hydrogenic species. VW, operating under severe radiation levels, have a primary safety role as tritium confinement barriers. Ionizing radiation enhances the (H') uptake and release at surfaces and diffusion rates in the bulk. Radiation damage modifies the material's bulk trapped inventories by increasing steady state trapping centre concentrations. An experimental programme is ongoing at CIEMAT, to quantify radiation effects on H transport characteristics and also the possible impact on the VW. The reference material for ECRH VW is CVD diamond. As a parallel activity, parametric transport assessments are being made in order to obtain a wide evaluation of permeation fluxes, ranges, and soluted/trapped inventories in CVD diamond. Transport models have been developed based on extended capabilities of finite differences integrator tool TMAP7. Special attention is paid to radiation parameters defining inputs acting on transport magnitudes. These inputs have been analysed by using ionizing/damage radiation transport tools such as MCNPX/SRIM. VW operational scenarios are discussed with special attention being paid to the ITER design assumptions for the values of H-species source terms (neutrals and implanted) in the ECRH system. The available material transport database with and without radiation is discussed and taken as reference for this parametric exercise. Permeation fluxes through base materials are shown to be below DRG limits established for ITER. (orig.)

  9. Reference Value Advisor: a new freeware set of macroinstructions to calculate reference intervals with Microsoft Excel.

    Science.gov (United States)

    Geffré, Anne; Concordet, Didier; Braun, Jean-Pierre; Trumel, Catherine

    2011-03-01

    International recommendations for determination of reference intervals have been recently updated, especially for small reference sample groups, and use of the robust method and Box-Cox transformation is now recommended. Unfortunately, these methods are not included in most software programs used for data analysis by clinical laboratories. We have created a set of macroinstructions, named Reference Value Advisor, for use in Microsoft Excel to calculate reference limits applying different methods. For any series of data, Reference Value Advisor calculates reference limits (with 90% confidence intervals [CI]) using a nonparametric method when n≥40 and by parametric and robust methods from native and Box-Cox transformed values; tests normality of distributions using the Anderson-Darling test and outliers using Tukey and Dixon-Reed tests; displays the distribution of values in dot plots and histograms and constructs Q-Q plots for visual inspection of normality; and provides minimal guidelines in the form of comments based on international recommendations. The critical steps in determination of reference intervals are correct selection of as many reference individuals as possible and analysis of specimens in controlled preanalytical and analytical conditions. Computing tools cannot compensate for flaws in selection and size of the reference sample group and handling and analysis of samples. However, if those steps are performed properly, Reference Value Advisor, available as freeware at http://www.biostat.envt.fr/spip/spip.php?article63, permits rapid assessment and comparison of results calculated using different methods, including currently unavailable methods. This allows for selection of the most appropriate method, especially as the program provides the CI of limits. It should be useful in veterinary clinical pathology when only small reference sample groups are available. ©2011 American Society for Veterinary Clinical Pathology.

  10. Sensitivity of Technical Efficiency Estimates to Estimation Methods: An Empirical Comparison of Parametric and Non-Parametric Approaches

    OpenAIRE

    de-Graft Acquah, Henry

    2014-01-01

    This paper highlights the sensitivity of technical efficiency estimates to estimation approaches using empirical data. Firm specific technical efficiency and mean technical efficiency are estimated using the non parametric Data Envelope Analysis (DEA) and the parametric Corrected Ordinary Least Squares (COLS) and Stochastic Frontier Analysis (SFA) approaches. Mean technical efficiency is found to be sensitive to the choice of estimation technique. Analysis of variance and Tukey’s test sugge...

  11. An Optimal Parametrization of Turbulent Scales

    Science.gov (United States)

    Thalabard, S.

    2015-12-01

    To numerically capture the large-scale dynamics of atmospheric flows, geophysicists need to rely on reasonable parametrizations of the energy transfers to and from the non-resolved small scale eddies, mediated through turbulence. The task is notoriously not trivial, and is typically solved by ingenious but ad-hoc elaborations on the concept of eddy viscosities. The difficulty is tied into the intrinsic Non-Gaussianity of turbulence, a feature that may explain why standard Quasi-Normal cumulant discard statistical closure strategies can fail dramatically, an example being the development of negative energy spectra in Millionshtchikov's 1941 Quasi-Normal (QN) theory. While Orszag's 1977 Eddy Damped Quasi Normal Markovian closure (EDQNM) provides an ingenious patch to the issue, the reason why the QN theory fails so badly is not so clear. Are closures necessarily either trivial or ad-hoc, when proxies for true ensemble averages are taken to be Gaussian ? The purpose of the talk is to answer negatively, using the lights of a new ``optimal closure framework'' recently exposed by [Turkington,2013]. For turbulence problems, the optimal closure allows a consistent use of a Gaussian Ansatz (and corresponding vanishing third cumulant) that also retains an intrinsic damping. The key to this apparent paradox lies in a clear distinction between the true ensemble averages and their proxies, most easily grasped provided one uses the Liouville equation as a starting point, rather than the cumulant hierarchy. Schematically said, closure is achieved by minimizing a lack-of-fit residual, which retains the intrinsic features of the true dynamics. The optimal closure is not restricted to the Gaussian modeling. Yet, for the sake of clarity, I will discuss the optimal closure on a problem where it can be entirely implemented, and compared to DNS : the relaxation of an arbitrarily far from equilibrium energy shell towards the Gibbs equilibrium for truncated Euler dynamics. Predictive

  12. Mixing parametrizations for ocean climate modelling

    Science.gov (United States)

    Gusev, Anatoly; Moshonkin, Sergey; Diansky, Nikolay; Zalesny, Vladimir

    2016-04-01

    The algorithm is presented of splitting the total evolutionary equations for the turbulence kinetic energy (TKE) and turbulence dissipation frequency (TDF), which is used to parameterize the viscosity and diffusion coefficients in ocean circulation models. The turbulence model equations are split into the stages of transport-diffusion and generation-dissipation. For the generation-dissipation stage, the following schemes are implemented: the explicit-implicit numerical scheme, analytical solution and the asymptotic behavior of the analytical solutions. The experiments were performed with different mixing parameterizations for the modelling of Arctic and the Atlantic climate decadal variability with the eddy-permitting circulation model INMOM (Institute of Numerical Mathematics Ocean Model) using vertical grid refinement in the zone of fully developed turbulence. The proposed model with the split equations for turbulence characteristics is similar to the contemporary differential turbulence models, concerning the physical formulations. At the same time, its algorithm has high enough computational efficiency. Parameterizations with using the split turbulence model make it possible to obtain more adequate structure of temperature and salinity at decadal timescales, compared to the simpler Pacanowski-Philander (PP) turbulence parameterization. Parameterizations with using analytical solution or numerical scheme at the generation-dissipation step of the turbulence model leads to better representation of ocean climate than the faster parameterization using the asymptotic behavior of the analytical solution. At the same time, the computational efficiency left almost unchanged relative to the simple PP parameterization. Usage of PP parametrization in the circulation model leads to realistic simulation of density and circulation with violation of T,S-relationships. This error is majorly avoided with using the proposed parameterizations containing the split turbulence model

  13. 2002 reference document; Document de reference 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This 2002 reference document of the group Areva, provides information on the society. Organized in seven chapters, it presents the persons responsible for the reference document and for auditing the financial statements, information pertaining to the transaction, general information on the company and share capital, information on company operation, changes and future prospects, assets, financial position, financial performance, information on company management and executive board and supervisory board, recent developments and future prospects. (A.L.B.)

  14. ITER parametric analysis and operational performance

    International Nuclear Information System (INIS)

    Perkins, L.J.; Spears, W.R.; Galambos, J.D.

    1991-01-01

    One of the key components of the ITER Conceptual Design Activities (CDA) is the determination of optimum design, investigation of operation in various modes, recommendation of baseline performance specifications, studies of sensitivity of ITER design to uncertainties in physics, investigation of operational flexibility, assessment of alternative designs, and determination of implications for extrapolation to prospective DEMO reactors. These terms of reference are reported in this document. Refs, figs and tabs

  15. The package PAKPDF ver. 1.1 of parametrizations of parton distribution functions in the proton

    International Nuclear Information System (INIS)

    Charchula, K.

    1991-08-01

    A FORTRAN package containing parametrizations of parton distribution functions (PDFS) in the proton is described. It allows an easy access to PDFS provided by several recent parametrizations and to some parameters characterizing particular parametrization. Some comments about the use of various parametrizations are also included. (orig.)

  16. Monitoring coastal marshes biomass with CASI: a comparison of parametric and non-parametric models

    Science.gov (United States)

    Mo, Y.; Kearney, M.

    2017-12-01

    Coastal marshes are important carbon sinks that face multiple natural and anthropogenic stresses. Optical remote sensing is a powerful tool for closely monitoring the biomass of coastal marshes. However, application of hyperspectral sensors on assessing the biomass of diverse coastal marsh ecosystems is limited. This study samples spectral and biophysical data from coastal freshwater, intermediate, brackish, and saline marshes in Louisiana, and develops parametric and non-parametric models for using the Compact Airborne Spectrographic Imager (CASI) to retrieve the marshes' biomass. Linear models and random forest models are developed from simulated CASI data (48 bands, 380-1050 nm, bandwidth 14 nm). Linear models are also developed using narrowband vegetation indices computed from all possible band combinations from the blue, red, and near infrared wavelengths. It is found that the linear models derived from the optimal narrowband vegetation indices provide strong predictions for the marshes' Leaf Area Index (LAI; R2 > 0.74 for ARVI), but not for their Aboveground Green Biomass (AGB; R2 > 0.25). The linear models derived from the simulated CASI data strongly predict the marshes' LAI (R2 = 0.93) and AGB (R2 = 0.71) and have 27 and 30 bands/variables in the final models through stepwise regression, respectively. The random forest models derived from the simulated CASI data also strongly predict the marshes' LAI and AGB (R2 = 0.91 and 0.84, respectively), where the most important variables for predicting LAI are near infrared bands at 784 and 756 nm and for predicting ABG are red bands at 684 and 670 nm. In sum, the random forest model is preferable for assessing coastal marsh biomass using CASI data as it offers high R2 for both LAI and AGB. The superior performance of the random forest model is likely to due to that it fully utilizes the full-spectrum data and makes no assumption of the approximate normality of the sampling population. This study offers solutions

  17. Parametric, nonparametric and parametric modelling of a chaotic circuit time series

    Science.gov (United States)

    Timmer, J.; Rust, H.; Horbelt, W.; Voss, H. U.

    2000-09-01

    The determination of a differential equation underlying a measured time series is a frequently arising task in nonlinear time series analysis. In the validation of a proposed model one often faces the dilemma that it is hard to decide whether possible discrepancies between the time series and model output are caused by an inappropriate model or by bad estimates of parameters in a correct type of model, or both. We propose a combination of parametric modelling based on Bock's multiple shooting algorithm and nonparametric modelling based on optimal transformations as a strategy to test proposed models and if rejected suggest and test new ones. We exemplify this strategy on an experimental time series from a chaotic circuit where we obtain an extremely accurate reconstruction of the observed attractor.

  18. PISC II: parametric studies. The purpose of the PISC II parametric studies programme

    International Nuclear Information System (INIS)

    Crutzen, S.

    1989-09-01

    The results of the PISC I round robin test of the ASME type procedure showed a very large dispersion. The amplitude of response of all defects varied very much among the teams from the 27 laboratories considered for the evaluation of results. Scatter on detection and sizing in PISC I was such that discussions started on the reasons for such a phenomenon when exactly the same procedure was used by all teams. The observation of two teams' results (JRC Ispra and ENEL Piacenza, Italy) induced the NDE Ispra laboratories to insist on the possible importance of equipment characteristics. All PISC members insisted on specific studies of the influence of defect characteristics as well as the role of cladding. These three chapters were the leading PIS laboratory exercises called Parametric Studies

  19. Physiological responses at short distances from a parametric speaker

    Directory of Open Access Journals (Sweden)

    Lee Soomin

    2012-06-01

    Full Text Available Abstract In recent years, parametric speakers have been used in various circumstances. In our previous studies, we verified that the physiological burden of the sound of parametric speaker set at 2.6 m from the subjects was lower than that of the general speaker. However, nothing has yet been demonstrated about the effects of the sound of a parametric speaker at the shorter distance between parametric speakers the human body. Therefore, we studied this effect on physiological functions and task performance. Nine male subjects participated in this study. They completed three consecutive sessions: a 20-minute quiet period as a baseline, a 30-minute mental task period with general speakers or parametric speakers, and a 20-minute recovery period. We measured electrocardiogram (ECG photoplethysmogram (PTG, electroencephalogram (EEG, systolic and diastolic blood pressure. Four experiments, one with a speaker condition (general speaker and parametric speaker, the other with a distance condition (0.3 m and 1.0 m, were conducted respectively at the same time of day on separate days. To examine the effects of the speaker and distance, three-way repeated measures ANOVA (speaker factor x distance factor x time factor were conducted. In conclusion, we found that the physiological responses were not significantly different between the speaker condition and the distance condition. Meanwhile, it was shown that the physiological burdens increased with progress in time independently of speaker condition and distance condition. In summary, the effects of the parametric speaker at the 2.6 m distance were not obtained at the distance of 1 m or less.

  20. Explicit/multi-parametric model predictive control (MPC) of linear discrete-time systems by dynamic and multi-parametric programming

    KAUST Repository

    Kouramas, K.I.; Faí sca, N.P.; Panos, C.; Pistikopoulos, E.N.

    2011-01-01

    This work presents a new algorithm for solving the explicit/multi- parametric model predictive control (or mp-MPC) problem for linear, time-invariant discrete-time systems, based on dynamic programming and multi-parametric programming techniques

  1. Biological reference materials and analysis of toxic elements

    Energy Technology Data Exchange (ETDEWEB)

    Subramanian, R; Sukumar, A

    1988-12-01

    Biological monitoring of toxic metal pollution in the environment requires quality control analysis with use of standard reference materials. A variety of biological tissues are increasingly used for analysis of element bioaccumulation, but the available Certified Reference Materials (CRMs) are insufficient. An attempt is made to review the studies made using biological reference materials for animal and human tissues. The need to have inter-laboratory studies and CRM in the field of biological monitoring of toxic metals is also discussed.

  2. Development of beta reference radiations

    International Nuclear Information System (INIS)

    Wan Zhaoyong; Cai Shanyu; Li Yanbo; Yin Wei; Feng Jiamin; Sun Yuhua; Li Yongqiang

    1997-09-01

    A system of beta reference radiation has been developed, that is composed of 740 MBq 147 Pm beta source, 74 MBq and 740 MBq 90 Sr + 90 Y β sources, compensation filters, a source handling tool, a source jig, spacing bars, a shutter, a control unit and a beta dose meter calibration stand. For 740 MBq 147 Pm and 74 MBq 90 Sr + 90 Y beta reference radiations with compensation filters and 740 MBq 90 Sr + 90 Y beta reference radiation without compensation filter, at 20 cm, 30 cm and 30 cm distance separately; the residual energy of maximum is 0.14 MeV, 1.98 MeV and 2.18 MeV separately; the absorbed dose to tissue D (0.07) is 1.547 mGy/h (1996-05-20), 5.037 mGy/h (1996-05-10) and 93.57 mGy/h (1996-05-15) separately; the total uncertainty is 3.0%, 1.7% and 1.7% separately. For the first and the second beta reference radiation, the dose rate variability in the area of 18 cm diameter in the plane perpendicular to the beta-ray beam axis is within +-6% and +-3% separately. (3 refs., 2 tabs., 8 figs.)

  3. VBE reference framework

    NARCIS (Netherlands)

    Afsarmanesh, H.; Camarinha-Matos, L.M.; Ermilova, E.; Camarinha-Matos, L.M.; Afsarmanesh, H.; Ollus, M.

    2008-01-01

    Defining a comprehensive and generic "reference framework" for Virtual organizations Breeding Environments (VBEs), addressing all their features and characteristics, is challenging. While the definition and modeling of VBEs has become more formalized during the last five years, "reference models"

  4. CMS Statistics Reference Booklet

    Data.gov (United States)

    U.S. Department of Health & Human Services — The annual CMS Statistics reference booklet provides a quick reference for summary information about health expenditures and the Medicare and Medicaid health...

  5. Changing quantum reference frames

    OpenAIRE

    Palmer, Matthew C.; Girelli, Florian; Bartlett, Stephen D.

    2013-01-01

    We consider the process of changing reference frames in the case where the reference frames are quantum systems. We find that, as part of this process, decoherence is necessarily induced on any quantum system described relative to these frames. We explore this process with examples involving reference frames for phase and orientation. Quantifying the effect of changing quantum reference frames serves as a first step in developing a relativity principle for theories in which all objects includ...

  6. Preparation, characterization and use of a reference material to proficiency testing for determination of metals in fish tissue in natura; Preparo, caracterizacao e uso de um material de referencia para ensaios de proficiencia para determinacao de metais em tecido de peixe in natura

    Energy Technology Data Exchange (ETDEWEB)

    Santana, Luciana Vieira de

    2013-07-01

    The proficiency tests are widely used to evaluate the analytical capacity of laboratories and also as part of the accreditation process. For this reason, are important tools for the control of the quality of the analytical results obtained in the laboratories that work directly with seafood companies. In Brazil there are no providers of proficiency testing for metals potentially toxic in fish tissues. In this work will be described all steps used for the production of reference materials to be used in a proficiency testing pilot study for As, Cd, Pb and Hg in fish tissue following the recommendations of the ISO Guide 35. He preparation scheme consisted in selecting the individuals, cleaning, grinding, homogenization and fortification with As, Cd and Pb in two concentration levels. The preparation resulted in 164 sachets of 10 g each. In order to evaluate the effect of gamma irradiation in the samples conservation 52 sachets were irradiated with {sup 60}Co (10.00 {+-} 1.05 kGy) in a gamma cell. This material with others non irradiated 52 sachets were used for the homogeneity and stability studies. The remaining 60 were used for the proficiency testing. The results demonstrated that both materials were homogeneous and presented good stability (during a period of 45 days). However, the irradiated material present better integrity, concerning biological degradation, when stored in ambient temperature. For this reason they were used to the proficiency testing pilot program. Ten laboratories participated in the proficiency testing pilot study and the results were evaluated using the following tests: z-score, confidence ellipse and En numbers. This work demonstrates the capability of the laboratory to produce reference materials as well as to organize and conduct proficiency testing. (author)

  7. Parametric investigation of heating due to magnetic fluid hyperthermia in a tumor with blood perfusion

    Energy Technology Data Exchange (ETDEWEB)

    Liangruksa, Monrudee [Department of Engineering Science and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 (United States); Ganguly, Ranjan [Department of Power Engineering, Jadavpur University, Kolkata 700098 (India); Puri, Ishwar K., E-mail: ikpuri@vt.ed [Department of Engineering Science and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 (United States)

    2011-03-15

    Magnetic fluid hyperthermia (MFH) is a cancer treatment that can selectively elevate the tumor temperature without significantly damaging the surrounding healthy tissue. Optimal MFH design requires a fundamental parametric investigation of the heating of soft materials by magnetic fluids. We model the problem of a spherical tumor and its surrounding healthy tissue that are heated by exciting a homogeneous dispersion of magnetic nanoparticles infused only into the tumor with an external AC magnetic field. The key dimensionless parameters influencing thermotherapy are the Peclet, Fourier, and Joule numbers. Analytical solutions for transient and steady hyperthermia provide correlations between these parameters and the portions of tumor and healthy tissue that are subjected to a threshold temperature beyond which they are damaged. Increasing the ratio of the Fourier and Joule numbers also increases the tumor temperature, but doing so can damage the healthy tissue. Higher magnetic heating is required for larger Peclet numbers due to the larger convection heat loss that occurs through blood perfusion. A comparison of the model predictions with previous experimental data for MFH applied to rabbit tumors shows good agreement. The optimal MFH conditions are identified based on two indices, the fraction I{sub T} of the tumor volume in which the local temperature is above a threshold temperature and the ratio I{sub N} of the damaged normal tissue volume to the tumor tissue volume that also lies above it. The spatial variation in the nanoparticle concentration is also considered. A Gaussian distribution provides efficacy while minimizing the possibility of generating a tumor hot spot. Varying the thermal properties of tumor and normal tissue alters I{sub T}and I{sub N} but the nature of the temperature distribution remains unchanged. - Research highlights: > Analytical model of magnetic fluid hyperthermia of tumor tissue perfused with magnetic nanoparticles that is surrounded

  8. Parametric investigation of heating due to magnetic fluid hyperthermia in a tumor with blood perfusion

    International Nuclear Information System (INIS)

    Liangruksa, Monrudee; Ganguly, Ranjan; Puri, Ishwar K.

    2011-01-01

    Magnetic fluid hyperthermia (MFH) is a cancer treatment that can selectively elevate the tumor temperature without significantly damaging the surrounding healthy tissue. Optimal MFH design requires a fundamental parametric investigation of the heating of soft materials by magnetic fluids. We model the problem of a spherical tumor and its surrounding healthy tissue that are heated by exciting a homogeneous dispersion of magnetic nanoparticles infused only into the tumor with an external AC magnetic field. The key dimensionless parameters influencing thermotherapy are the Peclet, Fourier, and Joule numbers. Analytical solutions for transient and steady hyperthermia provide correlations between these parameters and the portions of tumor and healthy tissue that are subjected to a threshold temperature beyond which they are damaged. Increasing the ratio of the Fourier and Joule numbers also increases the tumor temperature, but doing so can damage the healthy tissue. Higher magnetic heating is required for larger Peclet numbers due to the larger convection heat loss that occurs through blood perfusion. A comparison of the model predictions with previous experimental data for MFH applied to rabbit tumors shows good agreement. The optimal MFH conditions are identified based on two indices, the fraction I T of the tumor volume in which the local temperature is above a threshold temperature and the ratio I N of the damaged normal tissue volume to the tumor tissue volume that also lies above it. The spatial variation in the nanoparticle concentration is also considered. A Gaussian distribution provides efficacy while minimizing the possibility of generating a tumor hot spot. Varying the thermal properties of tumor and normal tissue alters I T and I N but the nature of the temperature distribution remains unchanged. - Research Highlights: →Analytical model of magnetic fluid hyperthermia of tumor tissue perfused with magnetic nanoparticles that is surrounded by healthy tissue

  9. Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies

    Science.gov (United States)

    Petibon, Yoann; Rakvongthai, Yothin; El Fakhri, Georges; Ouyang, Jinsong

    2017-05-01

    Dynamic PET myocardial perfusion imaging (MPI) used in conjunction with tracer kinetic modeling enables the quantification of absolute myocardial blood flow (MBF). However, MBF maps computed using the traditional indirect method (i.e. post-reconstruction voxel-wise fitting of kinetic model to PET time-activity-curves-TACs) suffer from poor signal-to-noise ratio (SNR). Direct reconstruction of kinetic parameters from raw PET projection data has been shown to offer parametric images with higher SNR compared to the indirect method. The aim of this study was to extend and evaluate the performance of a direct parametric reconstruction method using in vivo dynamic PET MPI data for the purpose of quantifying MBF. Dynamic PET MPI studies were performed on two healthy pigs using a Siemens Biograph mMR scanner. List-mode PET data for each animal were acquired following a bolus injection of ~7-8 mCi of 18F-flurpiridaz, a myocardial perfusion agent. Fully-3D dynamic PET sinograms were obtained by sorting the coincidence events into 16 temporal frames covering ~5 min after radiotracer administration. Additionally, eight independent noise realizations of both scans—each containing 1/8th of the total number of events—were generated from the original list-mode data. Dynamic sinograms were then used to compute parametric maps using the conventional indirect method and the proposed direct method. For both methods, a one-tissue compartment model accounting for spillover from the left and right ventricle blood-pools was used to describe the kinetics of 18F-flurpiridaz. An image-derived arterial input function obtained from a TAC taken in the left ventricle cavity was used for tracer kinetic analysis. For the indirect method, frame-by-frame images were estimated using two fully-3D reconstruction techniques: the standard ordered subset expectation maximization (OSEM) reconstruction algorithm on one side, and the one-step late maximum a posteriori (OSL-MAP) algorithm on the other

  10. Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in-vivo studies

    Science.gov (United States)

    Petibon, Yoann; Rakvongthai, Yothin; Fakhri, Georges El; Ouyang, Jinsong

    2017-01-01

    Dynamic PET myocardial perfusion imaging (MPI) used in conjunction with tracer kinetic modeling enables the quantification of absolute myocardial blood flow (MBF). However, MBF maps computed using the traditional indirect method (i.e. post-reconstruction voxel-wise fitting of kinetic model to PET time-activity-curves -TACs) suffer from poor signal-to-noise ratio (SNR). Direct reconstruction of kinetic parameters from raw PET projection data has been shown to offer parametric images with higher SNR compared to the indirect method. The aim of this study was to extend and evaluate the performance of a direct parametric reconstruction method using in-vivo dynamic PET MPI data for the purpose of quantifying MBF. Dynamic PET MPI studies were performed on two healthy pigs using a Siemens Biograph mMR scanner. List-mode PET data for each animal were acquired following a bolus injection of ~7-8 mCi of 18F-flurpiridaz, a myocardial perfusion agent. Fully-3D dynamic PET sinograms were obtained by sorting the coincidence events into 16 temporal frames covering ~5 min after radiotracer administration. Additionally, eight independent noise realizations of both scans - each containing 1/8th of the total number of events - were generated from the original list-mode data. Dynamic sinograms were then used to compute parametric maps using the conventional indirect method and the proposed direct method. For both methods, a one-tissue compartment model accounting for spillover from the left and right ventricle blood-pools was used to describe the kinetics of 18F-flurpiridaz. An image-derived arterial input function obtained from a TAC taken in the left ventricle cavity was used for tracer kinetic analysis. For the indirect method, frame-by-frame images were estimated using two fully-3D reconstruction techniques: the standard Ordered Subset Expectation Maximization (OSEM) reconstruction algorithm on one side, and the One-Step Late Maximum a Posteriori (OSL-MAP) algorithm on the other

  11. An appraisal of statistical procedures used in derivation of reference intervals.

    Science.gov (United States)

    Ichihara, Kiyoshi; Boyd, James C

    2010-11-01

    When conducting studies to derive reference intervals (RIs), various statistical procedures are commonly applied at each step, from the planning stages to final computation of RIs. Determination of the necessary sample size is an important consideration, and evaluation of at least 400 individuals in each subgroup has been recommended to establish reliable common RIs in multicenter studies. Multiple regression analysis allows identification of the most important factors contributing to variation in test results, while accounting for possible confounding relationships among these factors. Of the various approaches proposed for judging the necessity of partitioning reference values, nested analysis of variance (ANOVA) is the likely method of choice owing to its ability to handle multiple groups and being able to adjust for multiple factors. Box-Cox power transformation often has been used to transform data to a Gaussian distribution for parametric computation of RIs. However, this transformation occasionally fails. Therefore, the non-parametric method based on determination of the 2.5 and 97.5 percentiles following sorting of the data, has been recommended for general use. The performance of the Box-Cox transformation can be improved by introducing an additional parameter representing the origin of transformation. In simulations, the confidence intervals (CIs) of reference limits (RLs) calculated by the parametric method were narrower than those calculated by the non-parametric approach. However, the margin of difference was rather small owing to additional variability in parametrically-determined RLs introduced by estimation of parameters for the Box-Cox transformation. The parametric calculation method may have an advantage over the non-parametric method in allowing identification and exclusion of extreme values during RI computation.

  12. Incorporating parametric uncertainty into population viability analysis models

    Science.gov (United States)

    McGowan, Conor P.; Runge, Michael C.; Larson, Michael A.

    2011-01-01

    Uncertainty in parameter estimates from sampling variation or expert judgment can introduce substantial uncertainty into ecological predictions based on those estimates. However, in standard population viability analyses, one of the most widely used tools for managing plant, fish and wildlife populations, parametric uncertainty is often ignored in or discarded from model projections. We present a method for explicitly incorporating this source of uncertainty into population models to fully account for risk in management and decision contexts. Our method involves a two-step simulation process where parametric uncertainty is incorporated into the replication loop of the model and temporal variance is incorporated into the loop for time steps in the model. Using the piping plover, a federally threatened shorebird in the USA and Canada, as an example, we compare abundance projections and extinction probabilities from simulations that exclude and include parametric uncertainty. Although final abundance was very low for all sets of simulations, estimated extinction risk was much greater for the simulation that incorporated parametric uncertainty in the replication loop. Decisions about species conservation (e.g., listing, delisting, and jeopardy) might differ greatly depending on the treatment of parametric uncertainty in population models.

  13. A capacitive ultrasonic transducer based on parametric resonance.

    Science.gov (United States)

    Surappa, Sushruta; Satir, Sarp; Levent Degertekin, F

    2017-07-24

    A capacitive ultrasonic transducer based on a parametric resonator structure is described and experimentally demonstrated. The transducer structure, which we call capacitive parametric ultrasonic transducer (CPUT), uses a parallel plate capacitor with a movable membrane as part of a degenerate parametric series RLC resonator circuit with a resonance frequency of f o . When the capacitor plate is driven with an incident harmonic ultrasonic wave at the pump frequency of 2f o with sufficient amplitude, the RLC circuit becomes unstable and ultrasonic energy can be efficiently converted to an electrical signal at f o frequency in the RLC circuit. An important characteristic of the CPUT is that unlike other electrostatic transducers, it does not require DC bias or permanent charging to be used as a receiver. We describe the operation of the CPUT using an analytical model and numerical simulations, which shows drive amplitude dependent operation regimes including parametric resonance when a certain threshold is exceeded. We verify these predictions by experiments with a micromachined membrane based capacitor structure in immersion where ultrasonic waves incident at 4.28 MHz parametrically drive a signal with significant amplitude in the 2.14 MHz RLC circuit. With its unique features, the CPUT can be particularly advantageous for applications such as wireless power transfer for biomedical implants and acoustic sensing.

  14. Comparison of parametric and bootstrap method in bioequivalence test.

    Science.gov (United States)

    Ahn, Byung-Jin; Yim, Dong-Seok

    2009-10-01

    The estimation of 90% parametric confidence intervals (CIs) of mean AUC and Cmax ratios in bioequivalence (BE) tests are based upon the assumption that formulation effects in log-transformed data are normally distributed. To compare the parametric CIs with those obtained from nonparametric methods we performed repeated estimation of bootstrap-resampled datasets. The AUC and Cmax values from 3 archived datasets were used. BE tests on 1,000 resampled datasets from each archived dataset were performed using SAS (Enterprise Guide Ver.3). Bootstrap nonparametric 90% CIs of formulation effects were then compared with the parametric 90% CIs of the original datasets. The 90% CIs of formulation effects estimated from the 3 archived datasets were slightly different from nonparametric 90% CIs obtained from BE tests on resampled datasets. Histograms and density curves of formulation effects obtained from resampled datasets were similar to those of normal distribution. However, in 2 of 3 resampled log (AUC) datasets, the estimates of formulation effects did not follow the Gaussian distribution. Bias-corrected and accelerated (BCa) CIs, one of the nonparametric CIs of formulation effects, shifted outside the parametric 90% CIs of the archived datasets in these 2 non-normally distributed resampled log (AUC) datasets. Currently, the 80~125% rule based upon the parametric 90% CIs is widely accepted under the assumption of normally distributed formulation effects in log-transformed data. However, nonparametric CIs may be a better choice when data do not follow this assumption.

  15. A capacitive ultrasonic transducer based on parametric resonance

    Science.gov (United States)

    Surappa, Sushruta; Satir, Sarp; Levent Degertekin, F.

    2017-07-01

    A capacitive ultrasonic transducer based on a parametric resonator structure is described and experimentally demonstrated. The transducer structure, which we call capacitive parametric ultrasonic transducer (CPUT), uses a parallel plate capacitor with a movable membrane as part of a degenerate parametric series RLC resonator circuit with a resonance frequency of fo. When the capacitor plate is driven with an incident harmonic ultrasonic wave at the pump frequency of 2fo with sufficient amplitude, the RLC circuit becomes unstable and ultrasonic energy can be efficiently converted to an electrical signal at fo frequency in the RLC circuit. An important characteristic of the CPUT is that unlike other electrostatic transducers, it does not require DC bias or permanent charging to be used as a receiver. We describe the operation of the CPUT using an analytical model and numerical simulations, which shows drive amplitude dependent operation regimes including parametric resonance when a certain threshold is exceeded. We verify these predictions by experiments with a micromachined membrane based capacitor structure in immersion where ultrasonic waves incident at 4.28 MHz parametrically drive a signal with significant amplitude in the 2.14 MHz RLC circuit. With its unique features, the CPUT can be particularly advantageous for applications such as wireless power transfer for biomedical implants and acoustic sensing.

  16. Magnetorheological fluid dampers: a review of parametric modelling

    International Nuclear Information System (INIS)

    Wang, D H; Liao, W H

    2011-01-01

    Due to the inherent nonlinear nature of magnetorheological (MR) dampers, one of the challenging aspects for developing and utilizing these devices to achieve high performance is the development of models that can accurately describe their unique characteristics. In this review, the characteristics of MR dampers are summarized according to the measured responses under different conditions. On these bases, the considerations and methods of the parametric dynamic modelling for MR dampers are given and the state-of-the-art parametric dynamic modelling, identification and validation techniques for MR dampers are reviewed. In the past two decades, the models for MR dampers have been focused on how to improve the modelling accuracy. Although the force–displacement behaviour is well represented by most of the proposed dynamic models for MR dampers, no simple parametric models with high accuracy for MR dampers can be found. In addition, the parametric dynamic models for MR dampers with on-line updating ability and the inverse parametric models for MR dampers are scarcely explored. Moreover, whether one dynamic model for MR dampers can portray the force–displacement and force–velocity behaviour is not only determined by the dynamic model itself but also determined by the identification method. (topical review)

  17. Observational Signatures of Parametric Instability at 1AU

    Science.gov (United States)

    Bowen, T. A.; Bale, S. D.; Badman, S.

    2017-12-01

    Observations and simulations of inertial compressive turbulence in the solar wind are characterized by density structures anti-correlated with magnetic fluctuations parallel to the mean field. This signature has been interpreted as observational evidence for non-propagating pressure balanced structures (PBS), kinetic ion acoustic waves, as well as the MHD slow mode. Recent work, specifically Verscharen et al. (2017), has highlighted the unexpected fluid like nature of the solar wind. Given the high damping rates of parallel propagating compressive fluctuations, their ubiquity in satellite observations is surprising and suggests the presence of a driving process. One possible candidate for the generation of compressive fluctuations in the solar wind is the parametric instability, in which large amplitude Alfvenic fluctuations decay into parallel propagating compressive waves. This work employs 10 years of WIND observations in order to test the parametric decay process as a source of compressive waves in the solar wind through comparing collisionless damping rates of compressive fluctuations with growth rates of the parametric instability. Preliminary results suggest that generation of compressive waves through parametric decay is overdamped at 1 AU. However, the higher parametric decay rates expected in the inner heliosphere likely allow for growth of the slow mode-the remnants of which could explain density fluctuations observed at 1AU.

  18. Rapid parametric mapping of the longitudinal relaxation time T1 using two-dimensional variable flip angle magnetic resonance imaging at 1.5 Tesla, 3 Tesla, and 7 Tesla.

    Science.gov (United States)

    Dieringer, Matthias A; Deimling, Michael; Santoro, Davide; Wuerfel, Jens; Madai, Vince I; Sobesky, Jan; von Knobelsdorff-Brenkenhoff, Florian; Schulz-Menger, Jeanette; Niendorf, Thoralf

    2014-01-01

    Visual but subjective reading of longitudinal relaxation time (T1) weighted magnetic resonance images is commonly used for the detection of brain pathologies. For this non-quantitative measure, diagnostic quality depends on hardware configuration, imaging parameters, radio frequency transmission field (B1+) uniformity, as well as observer experience. Parametric quantification of the tissue T1 relaxation parameter offsets the propensity for these effects, but is typically time consuming. For this reason, this study examines the feasibility of rapid 2D T1 quantification using a variable flip angles (VFA) approach at magnetic field strengths of 1.5 Tesla, 3 Tesla, and 7 Tesla. These efforts include validation in phantom experiments and application for brain T1 mapping. T1 quantification included simulations of the Bloch equations to correct for slice profile imperfections, and a correction for B1+. Fast gradient echo acquisitions were conducted using three adjusted flip angles for the proposed T1 quantification approach that was benchmarked against slice profile uncorrected 2D VFA and an inversion-recovery spin-echo based reference method. Brain T1 mapping was performed in six healthy subjects, one multiple sclerosis patient, and one stroke patient. Phantom experiments showed a mean T1 estimation error of (-63±1.5)% for slice profile uncorrected 2D VFA and (0.2±1.4)% for the proposed approach compared to the reference method. Scan time for single slice T1 mapping including B1+ mapping could be reduced to 5 seconds using an in-plane resolution of (2×2) mm2, which equals a scan time reduction of more than 99% compared to the reference method. Our results demonstrate that rapid 2D T1 quantification using a variable flip angle approach is feasible at 1.5T/3T/7T. It represents a valuable alternative for rapid T1 mapping due to the gain in speed versus conventional approaches. This progress may serve to enhance the capabilities of parametric MR based lesion detection and

  19. Parametric study of a thorium model

    International Nuclear Information System (INIS)

    Lourenco, M.C.; Lipztein, J.L.; Szwarcwald, C.L.

    1997-01-01

    Full text. Models for radionuclides distribution in the human body and dosimetry involve assumptions on the biokinetic behaviour of the material among compartments representing organs and tissues in the body. The lack of knowledge about the metabolic behaviour of a radionuclide represents a factor of uncertainty in estimates of committed dose equivalent. An important problem in biokinetic modeling is the correct assignment of transfer coefficients and biological half-lives to body compartments. The purpose of this study is to analyze the variability in the activities of the body compartments in relation to the variations in the transfer coefficients and compartments biological half-lives in a certain model. A thorium specific recycling model for continuous exposure was used. Multiple regression analysis methods were applied to analyze the results

  20. Parametric study of a thorium model

    International Nuclear Information System (INIS)

    Lourenco, M.C.; Lipsztein, J.L.; Szwarcwald, C.L.

    2002-01-01

    Models for radionuclides distribution in the human body and dosimetry involve assumptions on the biokinetic behavior of the material among compartments representing organs and tissues in the body. One of the most important problem in biokinetic modeling is the assignment of transfer coefficients and biological half-lives to body compartments. In Brazil there are many areas of high natural radioactivity, where the population is chronically exposed to radionuclides of the thorium series. The uncertainties of the thorium biokinetic model are a major cause of uncertainty in the estimates of the committed dose equivalent of the population living in high background areas. The purpose of this study is to discuss the variability in the thorium activities accumulated in the body compartments in relation to the variations in the transfer coefficients and compartments biological half-lives of a thorium-recycling model for continuous exposure. Multiple regression analysis methods were applied to analyze the results. (author)

  1. IAEA biological reference materials

    International Nuclear Information System (INIS)

    Parr, R.M.; Schelenz, R.; Ballestra, S.

    1988-01-01

    The Analytical Quality Control Services programme of the IAEA encompasses a wide variety of intercomparisons and reference materials. This paper reviews only those aspects of the subject having to do with biological reference materials. The 1988 programme foresees 13 new intercomparison exercises, one for major, minor and trace elements, five for radionuclides, and seven for stable isotopes. Twenty-two natural matrix biological reference materials are available: twelve for major, minor and trace elements, six for radionuclides, and four for chlorinated hydrocarbons. Seven new intercomparisons and reference materials are in preparation or under active consideration. Guidelines on the correct use of reference materials are being prepared for publication in 1989 in consultation with other major international producers and users of biological reference materials. The IAEA database on available reference materials is being updated and expanded in scope, and a new publication is planned for 1989. (orig.)

  2. Parametric excitation of a SiN membrane via piezoelectricity

    Directory of Open Access Journals (Sweden)

    Shuhui Wu

    2018-01-01

    Full Text Available We develop a stoichiometric silicon nitride (SiN membrane-based electromechanical system, in which the spring constant of the mechanical resonator can be dynamically controlled via piezoelectric actuation. The degenerate parametric amplifier is studied in this configuration. We observe the splitting of mechanical mode in the response spectra of a phase-sensitive parametric amplifier. In addition, we demonstrate that the quality factor Q of the membrane oscillator can be significantly enhanced by more than two orders of magnitude due to the coherent amplification, reaching an effective Q factor of ∼3 × 108 at room temperature. The nonlinear effect on the parametric amplification is also investigated, as well as the thermomechanical noise squeezing. This system offers the possibility to integrate electrical, optical and mechanical degrees of freedom without compromising the exceptional material properties of SiN membranes, and can be a useful platform for studying cavity optoelectromechanics.

  3. Parametric excitation of a SiN membrane via piezoelectricity

    Science.gov (United States)

    Wu, Shuhui; Sheng, Jiteng; Zhang, Xiaotian; Wu, Yuelong; Wu, Haibin

    2018-01-01

    We develop a stoichiometric silicon nitride (SiN) membrane-based electromechanical system, in which the spring constant of the mechanical resonator can be dynamically controlled via piezoelectric actuation. The degenerate parametric amplifier is studied in this configuration. We observe the splitting of mechanical mode in the response spectra of a phase-sensitive parametric amplifier. In addition, we demonstrate that the quality factor Q of the membrane oscillator can be significantly enhanced by more than two orders of magnitude due to the coherent amplification, reaching an effective Q factor of ˜3 × 108 at room temperature. The nonlinear effect on the parametric amplification is also investigated, as well as the thermomechanical noise squeezing. This system offers the possibility to integrate electrical, optical and mechanical degrees of freedom without compromising the exceptional material properties of SiN membranes, and can be a useful platform for studying cavity optoelectromechanics.

  4. High frequency parametric wave phenomena and plasma heating: a review

    International Nuclear Information System (INIS)

    Porkolab, M.

    1975-11-01

    A survey of parametric instabilities in plasma, and associated particle heating, is presented. A brief summary of linear theory is given. The physical mechanism of decay instability, the purely growing mode (oscillating two-stream instability) and soliton and density cavity formation is presented. Effects of density gradients are discussed. Possible nonlinear saturation mechanisms are pointed out. Experimental evidence for the existence of parametric instabilities in both unmagnetized and magnetized plasmas is reviewed in some detail. Experimental observation of plasma heating associated with the presence of parametric instabilities is demonstrated by a number of examples. Possible application of these phenomena to heating of pellets by lasers and heating of magnetically confined fusion plasmas by high power microwave sources is discussed

  5. Parametric Resonance in a Time-Dependent Harmonic Oscillator

    Directory of Open Access Journals (Sweden)

    P. N. Nesterov

    2013-01-01

    Full Text Available In this paper, we study the phenomenon of appearance of new resonances in a timedependent harmonic oscillator under an oscillatory decreasing force. The studied equation belongs to the class of adiabatic oscillators and arises in connection with the spectral problem for the one-dimensional Schr¨odinger equation with Wigner–von Neumann type potential. We use a specially developed method for asymptotic integration of linear systems of differential equations with oscillatory decreasing coefficients. This method uses the ideas of the averaging method to simplify the initial system. Then we apply Levinson’s fundamental theorem to get the asymptotics for its solutions. Finally, we analyze the features of a parametric resonance phenomenon. The resonant frequencies of perturbation are found and the pointwise type of the parametric resonance phenomenon is established. In conclusion, we construct an example of a time-dependent harmonic oscillator (adiabatic oscillator in which the parametric resonances, mentioned in the paper, may occur.

  6. Circulation and Directional Amplification in the Josephson Parametric Converter

    Science.gov (United States)

    Hatridge, Michael

    Nonreciprocal transport and directional amplification of weak microwave signals are fundamental ingredients in performing efficient measurements of quantum states of flying microwave light. This challenge has been partly met, as quantum-limited amplification is now regularly achieved with parametrically-driven, Josephson-junction based superconducting circuits. However, these devices are typically non-directional, requiring external circulators to separate incoming and outgoing signals. Recently this limitation has been overcome by several proposals and experimental realizations of both directional amplifiers and circulators based on interference between several parametric processes in a single device. This new class of multi-parametrically driven devices holds the promise of achieving a variety of desirable characteristics simultaneously- directionality, reduced gain-bandwidth constraints and quantum-limited added noise, and are good candidates for on-chip integration with other superconducting circuits such as qubits.

  7. Simulation-based optimization parametric optimization techniques and reinforcement learning

    CERN Document Server

    Gosavi, Abhijit

    2003-01-01

    Simulation-Based Optimization: Parametric Optimization Techniques and Reinforcement Learning introduces the evolving area of simulation-based optimization. The book's objective is two-fold: (1) It examines the mathematical governing principles of simulation-based optimization, thereby providing the reader with the ability to model relevant real-life problems using these techniques. (2) It outlines the computational technology underlying these methods. Taken together these two aspects demonstrate that the mathematical and computational methods discussed in this book do work. Broadly speaking, the book has two parts: (1) parametric (static) optimization and (2) control (dynamic) optimization. Some of the book's special features are: *An accessible introduction to reinforcement learning and parametric-optimization techniques. *A step-by-step description of several algorithms of simulation-based optimization. *A clear and simple introduction to the methodology of neural networks. *A gentle introduction to converg...

  8. Wind Farm parametrization in the mesoscale model WRF

    DEFF Research Database (Denmark)

    Volker, Patrick; Badger, Jake; Hahmann, Andrea N.

    2012-01-01

    , but are parametrized as another sub-grid scale process. In order to appropriately capture the wind farm wake recovery and its direction, two properties are important, among others, the total energy extracted by the wind farm and its velocity deficit distribution. In the considered parametrization the individual...... the extracted force is proportional to the turbine area interfacing a grid cell. The sub-grid scale wake expansion is achieved by adding turbulence kinetic energy (proportional to the extracted power) to the flow. The validity of both wind farm parametrizations has been verified against observational data. We...... turbines produce a thrust dependent on the background velocity. For the sub-grid scale velocity deficit, the entrainment from the free atmospheric flow into the wake region, which is responsible for the expansion, is taken into account. Furthermore, since the model horizontal distance is several times...

  9. Noise-enhanced Parametric Resonance in Perturbed Galaxies

    Science.gov (United States)

    Sideris, Ioannis V.; Kandrup, Henry E.

    2004-02-01

    This paper describes how parametric resonances associated with a galactic potential subjected to relatively low-amplitude, strictly periodic time-dependent perturbations can be impacted by pseudo-random variations in the pulsation frequency, modeled as colored noise. One aim thereby is to allow for the effects of a changing oscillation frequency as the density distribution associated with a galaxy evolves during violent relaxation. Another is to mimic the possible effects of internal substructures, satellite galaxies, and/or a high-density environment. The principal conclusions are that allowing for a variable frequency does not vitiate the effects of parametric resonance, and that, in at least some cases, such variations can increase the overall importance of parametric resonance associated with systematic pulsations. In memory of Professor H. E. Kandrup, a brilliant scientist, excellent teacher, and good friend. His genius and sense of humor will be greatly missed.

  10. The parametric resonance—from LEGO Mindstorms to cold atoms

    Science.gov (United States)

    Kawalec, Tomasz; Sierant, Aleksandra

    2017-07-01

    We show an experimental setup based on a popular LEGO Mindstorms set, allowing us to both observe and investigate the parametric resonance phenomenon. The presented method is simple but covers a variety of student activities like embedded software development, conducting measurements, data collection and analysis. It may be used during science shows, as part of student projects and to illustrate the parametric resonance in mechanics or even quantum physics, during lectures or classes. The parametrically driven LEGO pendulum gains energy in a spectacular way, increasing its amplitude from 10° to about 100° within a few tens of seconds. We provide also a short description of a wireless absolute orientation sensor that may be used in quantitative analysis of driven or free pendulum movement.

  11. The parametric resonance—from LEGO Mindstorms to cold atoms

    International Nuclear Information System (INIS)

    Kawalec, Tomasz; Sierant, Aleksandra

    2017-01-01

    We show an experimental setup based on a popular LEGO Mindstorms set, allowing us to both observe and investigate the parametric resonance phenomenon. The presented method is simple but covers a variety of student activities like embedded software development, conducting measurements, data collection and analysis. It may be used during science shows, as part of student projects and to illustrate the parametric resonance in mechanics or even quantum physics, during lectures or classes. The parametrically driven LEGO pendulum gains energy in a spectacular way, increasing its amplitude from 10° to about 100° within a few tens of seconds. We provide also a short description of a wireless absolute orientation sensor that may be used in quantitative analysis of driven or free pendulum movement. (paper)

  12. Epicyclic helical channels for parametric resonance ionization cooling

    Energy Technology Data Exchange (ETDEWEB)

    Johson, Rolland Paul [Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA (United States); Derbenev, Yaroslav [Muons, Inc., Batavia, IL (United States)

    2015-08-23

    Proposed next-generation muon colliders will require major technical advances to achieve rapid muon beam cooling requirements. Parametric-resonance Ionization Cooling (PIC) is proposed as the final 6D cooling stage of a high-luminosity muon collider. In PIC, a half-integer parametric resonance causes strong focusing of a muon beam at appropriately placed energy absorbers while ionization cooling limits the beam’s angular spread. Combining muon ionization cooling with parametric resonant dynamics in this way should then allow much smaller final transverse muon beam sizes than conventional ionization cooling alone. One of the PIC challenges is compensation of beam aberrations over a sufficiently wide parameter range while maintaining the dynamical stability with correlated behavior of the horizontal and vertical betatron motion and dispersion. We explore use of a coupling resonance to reduce the dimensionality of the problem and to shift the dynamics away from non-linear resonances. PIC simulations are presented.

  13. Parametric Resonance in the Early Universe - A Fitting Analysis

    CERN Document Server

    Figueroa, Daniel G.

    2017-02-01

    Particle production via parametric resonance in the early Universe, is a non-perturbative, non-linear and out-of-equilibrium phenomenon. Although it is a well studied topic, whenever a new scenario exhibits parametric resonance, a full re-analysis is normally required. To avoid this tedious task, many works present often only a simplified linear treatment of the problem. In order to surpass this circumstance in the future, we provide a fitting analysis of parametric resonance through all its relevant stages: initial linear growth, non-linear evolution, and relaxation towards equilibrium. Using lattice simulations in an expanding grid in $3+1$ dimensions, we parametrise the dynamics' outcome scanning over the relevant ingredients: role of the oscillatory field, particle coupling strength, initial conditions, and background expansion rate. We emphasise the inaccuracy of the linear calculation of the decay time of the oscillatory field, and propose a more appropriate definition of this scale based on the subsequ...

  14. Parametric Hidden Markov Models for Recognition and Synthesis of Movements

    DEFF Research Database (Denmark)

    Herzog, Dennis; Krüger, Volker; Grest, Daniel

    2008-01-01

    In humanoid robotics, the recognition and synthesis of parametric movements plays an extraordinary role for robot human interaction. Such a parametric movement is a movement of a particular type (semantic), for example, similar pointing movements performed at different table-top positions....... For understanding the whole meaning of a movement of a human, the recognition of its type, likewise its parameterization are important. Only both together convey the whole meaning. Vice versa, for mimicry, the synthesis of movements for the motor control of a robot needs to be parameterized, e.g., by the relative...... the applicability for online recognition based on very noisy 3D tracking data. The use of a parametric representation of movements is shown in a robot demo, where a robot removes objects from a table as demonstrated by an advisor. The synthesis for motor control is performed for arbitrary table-top positions....

  15. Implementing quantum optics with parametrically driven superconducting circuits

    Science.gov (United States)

    Aumentado, Jose

    Parametric coupling has received much attention, in part because it forms the core of many low-noise amplifiers in superconducting quantum information experiments. However, parametric coupling in superconducting circuits is, as a general rule, simple to generate and forms the basis of a methodology for interacting microwave fields at different frequencies. In the quantum regime, this has important consequences, allowing relative novices to do experiments in superconducting circuits today that were previously heroic efforts in quantum optics and cavity-QED. In this talk, I'll give an overview of some of our work demonstrating parametric coupling within the context of circuit-QED as well as some of the possibilities this concept creates in our field.

  16. Estimating technical efficiency in the hospital sector with panel data: a comparison of parametric and non-parametric techniques.

    Science.gov (United States)

    Siciliani, Luigi

    2006-01-01

    Policy makers are increasingly interested in developing performance indicators that measure hospital efficiency. These indicators may give the purchasers of health services an additional regulatory tool to contain health expenditure. Using panel data, this study compares different parametric (econometric) and non-parametric (linear programming) techniques for the measurement of a hospital's technical efficiency. This comparison was made using a sample of 17 Italian hospitals in the years 1996-9. Highest correlations are found in the efficiency scores between the non-parametric data envelopment analysis under the constant returns to scale assumption (DEA-CRS) and several parametric models. Correlation reduces markedly when using more flexible non-parametric specifications such as data envelopment analysis under the variable returns to scale assumption (DEA-VRS) and the free disposal hull (FDH) model. Correlation also generally reduces when moving from one output to two-output specifications. This analysis suggests that there is scope for developing performance indicators at hospital level using panel data, but it is important that extensive sensitivity analysis is carried out if purchasers wish to make use of these indicators in practice.

  17. Parametric Level Statistics in Random Matrix Theory: Exact Solution

    International Nuclear Information System (INIS)

    Kanzieper, E.

    1999-01-01

    During recent several years, the theory of non-Gaussian random matrix ensembles has experienced a sound progress motivated by new ideas in quantum chromodynamics (QCD) and mesoscopic physics. Invariant non-Gaussian random matrix models appear to describe universal features of low-energy part of the spectrum of Dirac operator in QCD, and electron level statistics in normal conducting-superconducting hybrid structures. They also serve as a basis for constructing the toy models of universal spectral statistics expected at the edge of the metal-insulator transition. While conventional spectral statistics has received a detailed study in the context of RMT, quite a bit is known about parametric level statistics in non-Gaussian random matrix models. In this communication we report about exact solution to the problem of parametric level statistics in unitary invariant, U(N), non-Gaussian ensembles of N x N Hermitian random matrices with either soft or strong level confinement. The solution is formulated within the framework of the orthogonal polynomial technique and is shown to depend on both the unfolded two-point scalar kernel and the level confinement through a double integral transformation which, in turn, provides a constructive tool for description of parametric level correlations in non-Gaussian RMT. In the case of soft level confinement, the formalism developed is potentially applicable to a study of parametric level statistics in an important class of random matrix models with finite level compressibility expected to describe a disorder-induced metal-insulator transition. In random matrix ensembles with strong level confinement, the solution presented takes a particular simple form in the thermodynamic limit: In this case, a new intriguing connection relation between the parametric level statistics and the scalar two-point kernel of an unperturbed ensemble is demonstrated to emerge. Extension of the results obtained to higher-order parametric level statistics is

  18. The impact of parametrized convection on cloud feedback

    Science.gov (United States)

    Webb, Mark J.; Lock, Adrian P.; Bretherton, Christopher S.; Bony, Sandrine; Cole, Jason N. S.; Idelkadi, Abderrahmane; Kang, Sarah M.; Koshiro, Tsuyoshi; Kawai, Hideaki; Ogura, Tomoo; Roehrig, Romain; Shin, Yechul; Mauritsen, Thorsten; Sherwood, Steven C.; Vial, Jessica; Watanabe, Masahiro; Woelfle, Matthew D.; Zhao, Ming

    2015-01-01

    We investigate the sensitivity of cloud feedbacks to the use of convective parametrizations by repeating the CMIP5/CFMIP-2 AMIP/AMIP + 4K uniform sea surface temperature perturbation experiments with 10 climate models which have had their convective parametrizations turned off. Previous studies have suggested that differences between parametrized convection schemes are a leading source of inter-model spread in cloud feedbacks. We find however that ‘ConvOff’ models with convection switched off have a similar overall range of cloud feedbacks compared with the standard configurations. Furthermore, applying a simple bias correction method to allow for differences in present-day global cloud radiative effects substantially reduces the differences between the cloud feedbacks with and without parametrized convection in the individual models. We conclude that, while parametrized convection influences the strength of the cloud feedbacks substantially in some models, other processes must also contribute substantially to the overall inter-model spread. The positive shortwave cloud feedbacks seen in the models in subtropical regimes associated with shallow clouds are still present in the ConvOff experiments. Inter-model spread in shortwave cloud feedback increases slightly in regimes associated with trade cumulus in the ConvOff experiments but is quite similar in the most stable subtropical regimes associated with stratocumulus clouds. Inter-model spread in longwave cloud feedbacks in strongly precipitating regions of the tropics is substantially reduced in the ConvOff experiments however, indicating a considerable local contribution from differences in the details of convective parametrizations. In both standard and ConvOff experiments, models with less mid-level cloud and less moist static energy near the top of the boundary layer tend to have more positive tropical cloud feedbacks. The role of non-convective processes in contributing to inter-model spread in cloud

  19. Reference genes for normalization: A study of rat brain tissue

    DEFF Research Database (Denmark)

    Bonefeld, Birgit; Elfving, Betina; Wegener, Gregers

    2008-01-01

    are warranted. With the overall aim to inspect the gene expression of three target genes, NMDAR1, SORT, and CREB, in rat hippocampus, we tested a panel of eight HKGs, 18s rRNA, ActB, CycA, Gapd, Hmbs, Hprt1, Rpl13A, and Ywhaz in order to select the most stably expressed gene, using the NormFinder and ge...

  20. Using non-parametric methods in econometric production analysis

    DEFF Research Database (Denmark)

    Czekaj, Tomasz Gerard; Henningsen, Arne

    Econometric estimation of production functions is one of the most common methods in applied economic production analysis. These studies usually apply parametric estimation techniques, which obligate the researcher to specify the functional form of the production function. Most often, the Cobb...... results—including measures that are of interest of applied economists, such as elasticities. Therefore, we propose to use nonparametric econometric methods. First, they can be applied to verify the functional form used in parametric estimations of production functions. Second, they can be directly used...

  1. Parametrization of contrails in a comprehensive climate model

    Energy Technology Data Exchange (ETDEWEB)

    Ponater, M; Brinkop, S; Sausen, R; Schumann, U [Deutsche Forschungs- und Versuchsanstalt fuer Luft- und Raumfahrt e.V., Oberpfaffenhofen (Germany). Inst. fuer Physik der Atmosphaere

    1998-12-31

    A contrail parametrization scheme for a general circulation model (GCM) is presented. Guidelines for its development were that it should be based on the thermodynamic theory of contrail formation and that it should be consistent with the cloud parametrization scheme of the GCM. Results of a six-year test integration indicate reasonable results concerning the spatial and temporal development of both contrail coverage and contrail optical properties. Hence, the scheme forms a promising basis for the quantitative estimation of the contrail climatic impact. (author) 9 refs.

  2. Spin effect on parametric interactions of waves in magnetoplasmas

    International Nuclear Information System (INIS)

    Shahid, M.; Melrose, D. B.; Jamil, M.; Murtaza, G.

    2012-01-01

    The parametric decay instability of upper hybrid wave into low-frequency electromagnetic Shear Alfvén wave and Ordinary mode radiation (O-mode) has been investigated in an electron-ion plasma immersed in the uniform external magnetic field. Incorporating quantum effect due to electron spin, the fluid model has been used to investigate the linear and nonlinear response of the plasma species for three-wave coupling in a magnetoplasma. It is shown that the spin of electrons has considerable effect on the parametric decay of upper hybrid wave into Ordinary mode radiation (O-mode) and Shear Alfvén wave even in classical regime.

  3. Early Detection of Parametric Roll Resonance on Container Ships

    DEFF Research Database (Denmark)

    Galeazzi, Roberto; Blanke, Mogens; Poulsen, Niels Kjølstad

    2013-01-01

    Parametric roll resonance on ships is a nonlinear phenomenon where waves encountered at twice the natural roll frequency can bring the vessel dynamics into a bifurcation mode and lead to extreme values of roll. Recent years have seen several incidents with dramatic damage to container vessels...... the ship's speed and course, to escape from the bifurcation condition. This paper proposes nonparametric methods to detect the onset of roll resonance and demonstrates their performance. Theoretical conditions for parametric resonance are revisited and are used to develop efficient methods to detect its...... on experimental data from model tests and on data from a container ship crossing the Atlantic during a storm....

  4. On the parametrization of the Δ residue function

    International Nuclear Information System (INIS)

    Vasan, S.S.

    1976-01-01

    The complex residues at the Δ(1236) and Δ(1950) poles in the relevant partial-wave amplitudes provide information on the behaviour of the Δ Regge residue function in the resonance region u>0. Attempts to incorporate this information in parametrizations of the residue by functions that are real on the real u-axis result in residues which have unsatisfactory behaviour in the region u 2 . The choice of complex functions for the trajectory and residue removes this undesirable feature and provides a better representation of the residue in the resonance region, suggesting that complex parametrizations would be better suited to Regge analyses of near-backward scattering. (Auth.)

  5. Dispersion-Engineered Traveling Wave Kinetic Inductance Parametric Amplifier

    Science.gov (United States)

    Zmuidzinas, Jonas (Inventor); Day, Peter K. (Inventor)

    2014-01-01

    A traveling wave kinetic inductance parametric amplifier comprises a superconducting transmission line and a dispersion control element. The transmission line can include periodic variations of its dimension along its length. The superconducting material can include a high normal state resistivity material. In some instances the high normal state resistivity material includes nitrogen and a metal selected from the group consisting of titanium, niobium and vanadium. The traveling wave kinetic inductance parametric amplifier is expected to exhibit a noise temperature below 100 mK/GHz.

  6. Parametrization of contrails in a comprehensive climate model

    Energy Technology Data Exchange (ETDEWEB)

    Ponater, M.; Brinkop, S.; Sausen, R.; Schumann, U. [Deutsche Forschungs- und Versuchsanstalt fuer Luft- und Raumfahrt e.V., Oberpfaffenhofen (Germany). Inst. fuer Physik der Atmosphaere

    1997-12-31

    A contrail parametrization scheme for a general circulation model (GCM) is presented. Guidelines for its development were that it should be based on the thermodynamic theory of contrail formation and that it should be consistent with the cloud parametrization scheme of the GCM. Results of a six-year test integration indicate reasonable results concerning the spatial and temporal development of both contrail coverage and contrail optical properties. Hence, the scheme forms a promising basis for the quantitative estimation of the contrail climatic impact. (author) 9 refs.

  7. Frequency comb generation in a continuously pumped optical parametric oscillator

    Science.gov (United States)

    Mosca, S.; Parisi, M.; Ricciardi, I.; Leo, F.; Hansson, T.; Erkintalo, M.; Maddaloni, P.; De Natale, P.; Wabnitz, S.; De Rosa, M.

    2018-02-01

    We demonstrate optical frequency comb generation in a continuously pumped optical parametric oscillator, in the parametric region around half of the pump frequency. We also model the dynamics of such quadratic combs using a single time-domain mean-field equation, and obtain simulation results that are in good agreement with experimentally observed spectra. Moreover, we numerically investigate the coherence properties of simulated combs, showing the existence of correlated and phase-locked combs. Our work could pave the way for a new class of frequency comb sources, which may enable straightforward access to new spectral regions and stimulate novel applications of frequency combs.

  8. On the parametric cyclotron heating of a toroidal plasma

    International Nuclear Information System (INIS)

    Golovanivsky, K.C.; Punithavelu, A.M.

    1976-01-01

    The possibility of heating the ionic component of a dense plasma at the parametric cyclotron resonance, using a section of the conducting toroidal chamber of a large scale Tokamak as a resonance cavity, is considered. It is suggested to use the mode TE 011 to overcome the difficulties with the penetration of HF fields into such a dense plasma. The experimental investigation of parametric cyclotron heating of electrons in a overdense plasma (n/nsub(cut off)=10 2 ) on such a model has given hopeful results

  9. Synchronously Pumped Optical Parametric Oscillator with Intracavity Difference Frequency Mixing

    Science.gov (United States)

    1998-06-29

    departing from the Rrpubbc of Panama when traveling on official orders." * " De eonfortnidad con el Parrafo 5u) del Articulo XVII del Acuerdo para U...isotopic photochemistry using an optical parametric oscillator and a down converter," J. Opt. ( Paris ), , no. 14, pp. 43-48, 1983. [4] J. D. Kafka, M. L...isotopic photochemistry using an optical parametric oscillator and a down converter," J. Opt. ( Paris ), , no. 14, pp. 43-48, 1983. [4] J. D. Kafka, M. L

  10. A parametric LTR solution for discrete-time systems

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Jannerup, Ole Erik

    1989-01-01

    A parametric LTR (loop transfer recovery) solution for discrete-time compensators incorporating filtering observers which achieve exact recovery is presented for both minimum- and non-minimum-phase systems. First the recovery error, which defines the difference between the target loop transfer...... and the full loop transfer function, is manipulated into a general form involving the target loop transfer matrix and the fundamental recovery matrix. A parametric LTR solution based on the recovery matrix is developed. It is shown that the LQR/LTR (linear quadratic Gaussian/loop transfer recovery) solution...

  11. Theoretical and algorithmic advances in multi-parametric programming and control

    KAUST Repository

    Pistikopoulos, Efstratios N.; Dominguez, Luis; Panos, Christos; Kouramas, Konstantinos; Chinchuluun, Altannar

    2012-01-01

    This paper presents an overview of recent theoretical and algorithmic advances, and applications in the areas of multi-parametric programming and explicit/multi-parametric model predictive control (mp-MPC). In multi-parametric programming, advances include areas such as nonlinear multi-parametric programming (mp-NLP), bi-level programming, dynamic programming and global optimization for multi-parametric mixed-integer linear programming problems (mp-MILPs). In multi-parametric/explicit MPC (mp-MPC), advances include areas such as robust multi-parametric control, multi-parametric nonlinear MPC (mp-NMPC) and model reduction in mp-MPC. A comprehensive framework for multi-parametric programming and control is also presented. Recent applications include a hydrogen storage device, a fuel cell power generation system, an unmanned autonomous vehicle (UAV) and a hybrid pressure swing adsorption (PSA) system. © 2012 Springer-Verlag.

  12. Theoretical and algorithmic advances in multi-parametric programming and control

    KAUST Repository

    Pistikopoulos, Efstratios N.

    2012-04-21

    This paper presents an overview of recent theoretical and algorithmic advances, and applications in the areas of multi-parametric programming and explicit/multi-parametric model predictive control (mp-MPC). In multi-parametric programming, advances include areas such as nonlinear multi-parametric programming (mp-NLP), bi-level programming, dynamic programming and global optimization for multi-parametric mixed-integer linear programming problems (mp-MILPs). In multi-parametric/explicit MPC (mp-MPC), advances include areas such as robust multi-parametric control, multi-parametric nonlinear MPC (mp-NMPC) and model reduction in mp-MPC. A comprehensive framework for multi-parametric programming and control is also presented. Recent applications include a hydrogen storage device, a fuel cell power generation system, an unmanned autonomous vehicle (UAV) and a hybrid pressure swing adsorption (PSA) system. © 2012 Springer-Verlag.

  13. Kinetic parametric estimation in animal PET molecular imaging based on artificial immune network

    International Nuclear Information System (INIS)

    Chen Yuting; Ding Hong; Lu Rui; Huang Hongbo; Liu Li

    2011-01-01

    Objective: To develop an accurate,reliable method without the need of initialization in animal PET modeling for estimation of the tracer kinetic parameters based on the artificial immune network. Methods: The hepatic and left ventricular time activity curves (TACs) were obtained by drawing ROIs of liver tissue and left ventricle on dynamic 18 F-FDG PET imaging of small mice. Meanwhile, the blood TAC was analyzed by sampling the tail vein blood at different time points after injection. The artificial immune network for parametric optimization of pharmacokinetics (PKAIN) was adapted to estimate the model parameters and the metabolic rate of glucose (K i ) was calculated. Results: TACs of liver,left ventricle and tail vein blood were obtained.Based on the artificial immune network, K i in 3 mice was estimated as 0.0024, 0.0417 and 0.0047, respectively. The average weighted residual sum of squares of the output model generated by PKAIN was less than 0.0745 with a maximum standard deviation of 0.0084, which indicated that the proposed PKAIN method can provide accurate and reliable parametric estimation. Conclusion: The PKAIN method could provide accurate and reliable tracer kinetic modeling in animal PET imaging without the need of initialization of model parameters. (authors)

  14. Pixel-based parametric source depth map for Cerenkov luminescence imaging

    International Nuclear Information System (INIS)

    Altabella, L.; Spinelli, A.E.; Boschi, F.

    2016-01-01

    Optical tomography represents a challenging problem in optical imaging because of the intrinsically ill-posed inverse problem due to photon diffusion. Cerenkov luminescence tomography (CLT) for optical photons produced in tissues by several radionuclides (i.e.: 32P, 18F, 90Y), has been investigated using both 3D multispectral approach and multiviews methods. Difficult in convergence of 3D algorithms can discourage to use this technique to have information of depth and intensity of source. For these reasons, we developed a faster 2D corrected approach based on multispectral acquisitions, to obtain source depth and its intensity using a pixel-based fitting of source intensity. Monte Carlo simulations and experimental data were used to develop and validate the method to obtain the parametric map of source depth. With this approach we obtain parametric source depth maps with a precision between 3% and 7% for MC simulation and 5–6% for experimental data. Using this method we are able to obtain reliable information about the source depth of Cerenkov luminescence with a simple and flexible procedure

  15. Genetics Home Reference: osteoarthritis

    Science.gov (United States)

    ... damage is caused as the body attempts to repair and rebuild these tissues. The immune system, which plays a role in ... the result of the body's failed attempts to repair this damage. In healthy ... of the tissue. This balance is lost in osteoarthritis , leading to ...

  16. Indoor air: Reference bibliography

    International Nuclear Information System (INIS)

    Campbell, D.; Staves, D.; McDonald, S.

    1989-07-01

    The U. S. Environmental Protection Agency initially established the indoor air Reference Bibliography in 1987 as an appendix to the Indoor Air Quality Implementation Plan. The document was submitted to Congress as required under Title IV--Radon Gas and Indoor Air Quality Research of the Superfund Amendments and Reauthorization Act of 1986. The Reference Bibliography is an extensive bibliography of reference materials on indoor air pollution. The Bibliography contains over 4500 citations and continues to increase as new articles appear

  17. Parametric methods outperformed non-parametric methods in comparisons of discrete numerical variables

    Directory of Open Access Journals (Sweden)

    Sandvik Leiv

    2011-04-01

    Full Text Available Abstract Background The number of events per individual is a widely reported variable in medical research papers. Such variables are the most common representation of the general variable type called discrete numerical. There is currently no consensus on how to compare and present such variables, and recommendations are lacking. The objective of this paper is to present recommendations for analysis and presentation of results for discrete numerical variables. Methods Two simulation studies were used to investigate the performance of hypothesis tests and confidence interval methods for variables with outcomes {0, 1, 2}, {0, 1, 2, 3}, {0, 1, 2, 3, 4}, and {0, 1, 2, 3, 4, 5}, using the difference between the means as an effect measure. Results The Welch U test (the T test with adjustment for unequal variances and its associated confidence interval performed well for almost all situations considered. The Brunner-Munzel test also performed well, except for small sample sizes (10 in each group. The ordinary T test, the Wilcoxon-Mann-Whitney test, the percentile bootstrap interval, and the bootstrap-t interval did not perform satisfactorily. Conclusions The difference between the means is an appropriate effect measure for comparing two independent discrete numerical variables that has both lower and upper bounds. To analyze this problem, we encourage more frequent use of parametric hypothesis tests and confidence intervals.

  18. Resampling Approach for Determination of the Method for Reference Interval Calculation in Clinical Laboratory Practice▿

    Science.gov (United States)

    Pavlov, Igor Y.; Wilson, Andrew R.; Delgado, Julio C.

    2010-01-01

    Reference intervals (RI) play a key role in clinical interpretation of laboratory test results. Numerous articles are devoted to analyzing and discussing various methods of RI determination. The two most widely used approaches are the parametric method, which assumes data normality, and a nonparametric, rank-based procedure. The decision about which method to use is usually made arbitrarily. The goal of this study was to demonstrate that using a resampling approach for the comparison of RI determination techniques could help researchers select the right procedure. Three methods of RI calculation—parametric, transformed parametric, and quantile-based bootstrapping—were applied to multiple random samples drawn from 81 values of complement factor B observations and from a computer-simulated normally distributed population. It was shown that differences in RI between legitimate methods could be up to 20% and even more. The transformed parametric method was found to be the best method for the calculation of RI of non-normally distributed factor B estimations, producing an unbiased RI and the lowest confidence limits and interquartile ranges. For a simulated Gaussian population, parametric calculations, as expected, were the best; quantile-based bootstrapping produced biased results at low sample sizes, and the transformed parametric method generated heavily biased RI. The resampling approach could help compare different RI calculation methods. An algorithm showing a resampling procedure for choosing the appropriate method for RI calculations is included. PMID:20554803

  19. Android quick APIs reference

    CERN Document Server

    Cinar, Onur

    2015-01-01

    The Android Quick APIs Reference is a condensed code and APIs reference for the new Google Android 5.0 SDK. It presents the essential Android APIs in a well-organized format that can be used as a handy reference. You won't find any technical jargon, bloated samples, drawn out history lessons, or witty stories in this book. What you will find is a software development kit and APIs reference that is concise, to the point and highly accessible. The book is packed with useful information and is a must-have for any mobile or Android app developer or programmer. In the Android Quick APIs Refe

  20. On unambiguous parametrization of neutron cross-sections in the low-energy region

    International Nuclear Information System (INIS)

    Novoselov, G.M.; Kolomiets, V.M.

    1982-08-01

    One of the most important aims of analysis in the resonance region is the evaluation of neutron resonance parameters on the basis of a given formalism of the theory of nuclear reactions. However, the task of finding resonance parameters from experimental data on the energy dependence of cross-sections is subject to a number of difficulties. These difficulties are not only of a theoretical character associated with the selection of one version or another of the theory taking into account the effects necessary (interference between resonances, Doppler effect etc.), but also involve problems of principle. Whether the set of parameters found is the only possible one within the context of a single formalism used remains open. The specific features of processing the experimental data are such that even with good resolution a number of overlapping resonances (occurring as a result of the fluctuation in inter-level distances or the Doppler effect) may be classified as an isolated resonance. Moreover, even given a very weak inter-level interference and Doppler effect, unambiguous parametrization of the cross-sections is not always possible. In the present paper these questions (the choice of the approximation needed for describing experimentally observed cross-sections, allowance for inter-level interference and the Doppler effect and the possibility of ambiguous reproduction of the resonance structure of cross-sections) are examined with reference to the parametrization of the total cross-sections for non-fissionable nuclei in the low-neutron-energy region

  1. Robust non-parametric one-sample tests for the analysis of recurrent events.

    Science.gov (United States)

    Rebora, Paola; Galimberti, Stefania; Valsecchi, Maria Grazia

    2010-12-30

    One-sample non-parametric tests are proposed here for inference on recurring events. The focus is on the marginal mean function of events and the basis for inference is the standardized distance between the observed and the expected number of events under a specified reference rate. Different weights are considered in order to account for various types of alternative hypotheses on the mean function of the recurrent events process. A robust version and a stratified version of the test are also proposed. The performance of these tests was investigated through simulation studies under various underlying event generation processes, such as homogeneous and nonhomogeneous Poisson processes, autoregressive and renewal processes, with and without frailty effects. The robust versions of the test have been shown to be suitable in a wide variety of event generating processes. The motivating context is a study on gene therapy in a very rare immunodeficiency in children, where a major end-point is the recurrence of severe infections. Robust non-parametric one-sample tests for recurrent events can be useful to assess efficacy and especially safety in non-randomized studies or in epidemiological studies for comparison with a standard population. Copyright © 2010 John Wiley & Sons, Ltd.

  2. Value at risk (VaR in uncertainty: Analysis with parametric method and black & scholes simulations

    Directory of Open Access Journals (Sweden)

    Humberto Banda Ortiz

    2014-07-01

    Full Text Available VaR is the most accepted risk measure worldwide and the leading reference in any risk management assessment. However, its methodology has important limitations which makes it unreliable in contexts of crisis or high uncertainty. For this reason, the aim of this work is to test the VaR accuracy when is employed in contexts of volatility, for which we compare the VaR outcomes in scenarios of both stability and uncertainty, using the parametric method and a historical simulation based on data generated with the Black & Scholes model. VaR main objective is the prediction of the highest expected loss for any given portfolio, but even when it is considered a useful tool for risk management under conditions of markets stability, we found that it is substantially inaccurate in contexts of crisis or high uncertainty. In addition, we found that the Black & Scholes simulations lead to underestimate the expected losses, in comparison with the parametric method and we also found that those disparities increase substantially in times of crisis. In the first section of this work we present a brief context of risk management in finance. In section II we present the existent literature relative to the VaR concept, its methods and applications. In section III we describe the methodology and assumptions used in this work. Section IV is dedicated to expose the findings. And finally, in Section V we present our conclusions.

  3. Neoproteoglycans in tissue engineering

    Science.gov (United States)

    Weyers, Amanda; Linhardt, Robert J.

    2014-01-01

    Proteoglycans, comprised of a core protein to which glycosaminoglycan chains are covalently linked, are an important structural and functional family of macromolecules found in the extracellular matrix. Advances in our understanding of biological interactions have lead to a greater appreciation for the need to design tissue engineering scaffolds that incorporate mimetics of key extracellular matrix components. A variety of synthetic and semisynthetic molecules and polymers have been examined by tissue engineers that serve as structural, chemical and biological replacements for proteoglycans. These proteoglycan mimetics have been referred to as neoproteoglycans and serve as functional and therapeutic replacements for natural proteoglycans that are often unavailable for tissue engineering studies. Although neoproteoglycans have important limitations, such as limited signaling ability and biocompatibility, they have shown promise in replacing the natural activity of proteoglycans through cell and protein binding interactions. This review focuses on the recent in vivo and in vitro tissue engineering applications of three basic types of neoproteoglycan structures, protein–glycosaminoglycan conjugates, nano-glycosaminoglycan composites and polymer–glycosaminoglycan complexes. PMID:23399318

  4. Search for evidence of a preferred reference frame

    International Nuclear Information System (INIS)

    Warburton, R.J.; Goodkind, J.M.

    1976-01-01

    Some gravity theories, in contradiction to general relativity, allow the existence of a universal preferred reference frame. Also allowed in some theories can be a galaxy-induced anisotropy of the gravitation constant. The parametrized post-Newtonian theory predicts that in these cases there will be anomalous Earth tide amplitudes at specific frequencies. An 18-month Earth tide record obtained with the superconducting gravimeter has been examined for such anomalies. The data allow for the existence of such effects but cannot prove it because of uncertainties concerning geophysical perturbations of the tides. However, an upper limit to the preferred frame parameter, α 2 , of the parametrized post-Newtonian formalism is established at 2 x 10 -3 . The results also set a less rigorous limit on the anisotropy parameter, zeta/sub omega/, of order 10 -3

  5. Parametric decay of lower hybrid wave into drift waves

    International Nuclear Information System (INIS)

    Sanuki, Heiji.

    1976-12-01

    A dispersion relation describing the parametric decay of a lower hybrid wave into an electrostatic drift wave and a drift Alfven wave is derived for an inhomogeneous magnetized plasma. Particularly the stimulated scattering of a drift Alfven wave in such a plasma was investigated in detail. The resonance backscattering instability is found to yield the minimum threshold. (auth.)

  6. Parametric estimation for reinforced concrete relief shelter for Aceh cases

    Science.gov (United States)

    Atthaillah; Saputra, Eri; Iqbal, Muhammad

    2018-05-01

    This paper was a work in progress (WIP) to discover a rapid parametric framework for post-disaster permanent shelter’s materials estimation. The intended shelters were reinforced concrete construction with bricks as its wall. Inevitably, in post-disaster cases, design variations were needed to help suited victims condition. It seemed impossible to satisfy a beneficiary with a satisfactory design utilizing the conventional method. This study offered a parametric framework to overcome slow construction-materials estimation issue against design variations. Further, this work integrated parametric tool, which was Grasshopper to establish algorithms that simultaneously model, visualize, calculate and write the calculated data to a spreadsheet in a real-time. Some customized Grasshopper components were created using GHPython scripting for a more optimized algorithm. The result from this study was a partial framework that successfully performed modeling, visualization, calculation and writing the calculated data simultaneously. It meant design alterations did not escalate time needed for modeling, visualization, and material estimation. Further, the future development of the parametric framework will be made open source.

  7. Multi-level approach for parametric roll analysis

    Science.gov (United States)

    Kim, Taeyoung; Kim, Yonghwan

    2011-03-01

    The present study considers multi-level approach for the analysis of parametric roll phenomena. Three kinds of computation method, GM variation, impulse response function (IRF), and Rankine panel method, are applied for the multi-level approach. IRF and Rankine panel method are based on the weakly nonlinear formulation which includes nonlinear Froude- Krylov and restoring forces. In the computation result of parametric roll occurrence test in regular waves, IRF and Rankine panel method show similar tendency. Although the GM variation approach predicts the occurrence of parametric roll at twice roll natural frequency, its frequency criteria shows a little difference. Nonlinear roll motion in bichromatic wave is also considered in this study. To prove the unstable roll motion in bichromatic waves, theoretical and numerical approaches are applied. The occurrence of parametric roll is theoretically examined by introducing the quasi-periodic Mathieu equation. Instability criteria are well predicted from stability analysis in theoretical approach. From the Fourier analysis, it has been verified that difference-frequency effects create the unstable roll motion. The occurrence of unstable roll motion in bichromatic wave is also observed in the experiment.

  8. Containment parametric analysis for loss of coolant accident

    International Nuclear Information System (INIS)

    Fabjan, L.

    1985-01-01

    Full text: This paper presents parametric analysis of double containment response to LOCA using CONTEMPT-LT/28 code. The influence of the active and passive heat sinks on thermodynamic parameters in the containment after big and small LOCA was considered. (author)

  9. DEVELOPING PARAMETRIC BUILDING MODELS – THE GANDIS USE CASE

    Directory of Open Access Journals (Sweden)

    W. Thaller

    2012-09-01

    Full Text Available In the course of a project related to green building design, we have created a group of eight parametric building models that can be manipulated interactively with respect to dimensions, number of floors, and a few other parameters. We report on the commonalities and differences between the models and the abstractions that we were able to identify.

  10. Parametric resonance in the early Universe—a fitting analysis

    Energy Technology Data Exchange (ETDEWEB)

    Figueroa, Daniel G. [Theoretical Physics Department, CERN, Geneva (Switzerland); Torrentí, Francisco, E-mail: daniel.figueroa@cern.ch, E-mail: f.torrenti@csic.es [Instituto de Física Teórica IFT-UAM/CSIC, Universidad Autónoma de Madrid, Cantoblanco 28049, Madrid (Spain)

    2017-02-01

    Particle production via parametric resonance in the early Universe, is a non-perturbative, non-linear and out-of-equilibrium phenomenon. Although it is a well studied topic, whenever a new scenario exhibits parametric resonance, a full re-analysis is normally required. To avoid this tedious task, many works present often only a simplified linear treatment of the problem. In order to surpass this circumstance in the future, we provide a fitting analysis of parametric resonance through all its relevant stages: initial linear growth, non-linear evolution, and relaxation towards equilibrium. Using lattice simulations in an expanding grid in 3+1 dimensions, we parametrize the dynamics' outcome scanning over the relevant ingredients: role of the oscillatory field, particle coupling strength, initial conditions, and background expansion rate. We emphasize the inaccuracy of the linear calculation of the decay time of the oscillatory field, and propose a more appropriate definition of this scale based on the subsequent non-linear dynamics. We provide simple fits to the relevant time scales and particle energy fractions at each stage. Our fits can be applied to post-inflationary preheating scenarios, where the oscillatory field is the inflaton, or to spectator-field scenarios, where the oscillatory field can be e.g. a curvaton, or the Standard Model Higgs.

  11. Testing Parametric versus Semiparametric Modelling in Generalized Linear Models

    NARCIS (Netherlands)

    Härdle, W.K.; Mammen, E.; Müller, M.D.

    1996-01-01

    We consider a generalized partially linear model E(Y|X,T) = G{X'b + m(T)} where G is a known function, b is an unknown parameter vector, and m is an unknown function.The paper introduces a test statistic which allows to decide between a parametric and a semiparametric model: (i) m is linear, i.e.

  12. SEMIPARAMETRIC VERSUS PARAMETRIC CLASSIFICATION MODELS - AN APPLICATION TO DIRECT MARKETING

    NARCIS (Netherlands)

    BULT, [No Value

    In this paper we are concerned with estimation of a classification model using semiparametric and parametric methods. Benefits and limitations of semiparametric models in general, and of Manski's maximum score method in particular, are discussed. The maximum score method yields consistent estimates

  13. Non-Parametric Analysis of Rating Transition and Default Data

    DEFF Research Database (Denmark)

    Fledelius, Peter; Lando, David; Perch Nielsen, Jens

    2004-01-01

    We demonstrate the use of non-parametric intensity estimation - including construction of pointwise confidence sets - for analyzing rating transition data. We find that transition intensities away from the class studied here for illustration strongly depend on the direction of the previous move b...

  14. Nonlinear dynamics of a parametrically driven sine-Gordon system

    DEFF Research Database (Denmark)

    Grønbech-Jensen, Niels; Kivshar, Yuri S.; Samuelsen, Mogens Rugholm

    1993-01-01

    We consider a sine-Gordon system, driven by an ac parametric force in the presence of loss. It is demonstrated that a breather can be maintained in a steady state at half of the external frequency. In the small-amplitude limit the effect is described by an effective nonlinear Schrodinger equation...

  15. Absolute differential yield of parametric x-ray radiation

    International Nuclear Information System (INIS)

    Shchagin, A.V.; Pristupa, V.I.; Khizhnyak, N.A.

    1993-01-01

    The results of measurements of absolute differential yield of parametric X-ray radiation (PXR) in thin single crystal are presented for the first time. It has been established that the experimental results are in good agreement with theoretical calculations according with kinematical theory. The influence of density effect on PXR properties is discussed. (author). 19 refs., 7 figs

  16. A parametric level-set method for partially discrete tomography

    NARCIS (Netherlands)

    A. Kadu (Ajinkya); T. van Leeuwen (Tristan); K.J. Batenburg (Joost)

    2017-01-01

    textabstractThis paper introduces a parametric level-set method for tomographic reconstruction of partially discrete images. Such images consist of a continuously varying background and an anomaly with a constant (known) grey-value. We express the geometry of the anomaly using a level-set function,

  17. Asymmetric gain-saturated spectrum in fiber optical parametric amplifiers

    DEFF Research Database (Denmark)

    Lali-Dastjerdi, Zohreh; Rottwitt, Karsten; Galili, Michael

    2012-01-01

    We demonstrate experimentally and numerically an unexpected spectral asymmetry in the saturated-gain spectrum of single-pump fiber optical parametric amplifiers. The interaction between higher-order four-wave mixing products and dispersive waves radiated as an effect of third-order dispersion inf...... characteristics of the amplifier and shows local maxima for specific dispersion values....

  18. Parametric Cost Estimates for an International Competitive Edge

    International Nuclear Information System (INIS)

    Murphy, L.T.; Hickey, M.

    2006-01-01

    This paper summarizes the progress to date by CH2M HILL and the UKAEA in development of a parametric modelling capability for estimating the costs of large nuclear decommissioning projects in the United Kingdom (UK) and Europe. The ability to successfully apply parametric cost estimating techniques will be a key factor to commercial success in the UK and European multi-billion dollar waste management, decommissioning and environmental restoration markets. The most useful parametric models will be those that incorporate individual components representing major elements of work: reactor decommissioning, fuel cycle facility decommissioning, waste management facility decommissioning and environmental restoration. Models must be sufficiently robust to estimate indirect costs and overheads, permit pricing analysis and adjustment, and accommodate the intricacies of international monetary exchange, currency fluctuations and contingency. The development of a parametric cost estimating capability is also a key component in building a forward estimating strategy. The forward estimating strategy will enable the preparation of accurate and cost-effective out-year estimates, even when work scope is poorly defined or as yet indeterminate. Preparation of cost estimates for work outside the organizations current sites, for which detailed measurement is not possible and historical cost data does not exist, will also be facilitated. (authors)

  19. Parametric inference for discretely sampled stochastic differential equations

    DEFF Research Database (Denmark)

    Sørensen, Michael

    A review is given of parametric estimation methods for discretely sampled mul- tivariate diffusion processes. The main focus is on estimating functions and asymp- totic results. Maximum likelihood estimation is briefly considered, but the emphasis is on computationally less demanding martingale...

  20. Chaotic neoclassical separatrix dissipation in parametric drift-wave decay.

    Science.gov (United States)

    Kabantsev, A A; Tsidulko, Yu A; Driscoll, C F

    2014-02-07

    Experiments and theory characterize a parametric decay instability between plasma drift waves when the nonlinear coupling is modified by an electrostatic barrier. Novel mode coupling terms representing enhanced dissipation and mode phase shifts are caused by chaotic separatrix crossings on the wave-ruffled separatrix. Experimental determination of these coupling terms is in broad agreement with new chaotic neoclassical transport analyses.

  1. Gain characteristics of a saturated fiber optic parametric amplifier

    DEFF Research Database (Denmark)

    Rottwitt, Karsten; Lorenzen, Michael Rodas; Noordegraaf, Danny

    2008-01-01

    In this work we discuss saturation performance of a fiber optic parametric amplifier. A simple numerical model is described and applied to specific cases. A system experiment using a saturated amplifier illustrates a 4 dB improvement in required signal to noise ratio for a fixed bit error ratio....

  2. Linear time heteronymous damping in nonlinear parametric systems

    Czech Academy of Sciences Publication Activity Database

    Hortel, Milan; Škuderová, Alena; Houfek, Martin

    2016-01-01

    Roč. 40, 23-24 (2016), s. 10038-10051 ISSN 0307-904X Institutional support: RVO:61388998 Keywords : nonlinear dynamics of systems * parametric systems * time heteronymous damping * gears Subject RIV: JT - Propulsion, Motors ; Fuels Impact factor: 2.350, year: 2016

  3. Exchange of parametric bridge models using a neutral data format

    NARCIS (Netherlands)

    Ji, Y.; Borrmann, André; Beetz, J.; Obergrießer, M.

    2013-01-01

    Parametric modeling is a well-established methodology in the field of mechanical engineering. It allows the creation of flexible geometric models using parameters for dimensions and makes it possible to define numeric relationships between these parameters by means of mathematical formulas and

  4. Involute Spur Gear Template Development by Parametric Technique ...

    African Journals Online (AJOL)

    There are many methods available for developing profiles of gear and spline teeth. Most of the techniques are inaccurate because they use only an approximation of the involute curve profile. The parametric method developed in this paper provides accurate involute curve creation using formulas and exact geometric ...

  5. Perturbation analysis of a parametrically changed sine-Gordon equation

    DEFF Research Database (Denmark)

    Sakai, S.; Samuelsen, Mogens Rugholm; Olsen, O. H.

    1987-01-01

    A long Josephson junction with a spatially varying inductance is a physical manifestation of a modified sine-Gordon equation with parametric perturbation. Soliton propagation in such Josephson junctions is discussed. First, for an adiabatic model where the inductance changes smoothly compared...

  6. Two-parametric model of metals hardening during cold working

    International Nuclear Information System (INIS)

    Khajkin, B.E.

    1985-01-01

    Mathematical models of cold working metal resistance σ depending on deformation degree have been analyzed. Advantage of two-parametric formula combining simplicity with satisfactory accuracy of experimental data approximation is noted. The formula is convenient when determining value σ, which is average with respect of deformation location, as average geometric value

  7. Revisiting non-degenerate parametric down-conversion

    Indian Academy of Sciences (India)

    conversion process is studied by recasting the time evolution equations for the basic op- erators in an equivalent ... We consider a model of non-degenerate parametric down-conversion process com- posed of two coupled ..... e−iωat and eiωbt have been left out in writing down the final results in ref. [4], even though these ...

  8. Estimation of Parametric Fault in Closed-loop Systems

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Poulsen, Niels Kjølstad

    2015-01-01

    The aim of this paper is to present a method for estimation of parametric faults in closed-loop systems. The key technology applied in this paper is coprime factorization of both the dynamic system as well as the feedback controller. Using the Youla-Jabr-Bongiorno-Kucera (YJBK) parameterization...

  9. An empirical analysis of one, two, and three parametric logistic ...

    African Journals Online (AJOL)

    The purpose of this study was to determine the three parametric logistic IRT methods in dichotomous and ordinal test items due to differential item functioning using statistical DIF detection methods of SIBTEST, GMH, and LDFA. The study adopted instrumentation research design. The sample consisted of an intact class of ...

  10. Numerical Modelling of Spontaneous Emission in Optical Parametric Amplifiers

    DEFF Research Database (Denmark)

    Friis, Søren Michael Mørk; Andersen, Ulrik Lund; Rottwitt, Karsten

    2013-01-01

    Fiber optical parametric processes offer a wide range of applications including phase sensitive as well as phase insensitive amplification, wavelength conversion and signal regeneration. One of the difficult challenges is any of these applications is to predict their associated noise performance....

  11. Absolute parametric instability in a nonuniform plane plasma ...

    Indian Academy of Sciences (India)

    Abstract. The paper reports an analysis of the effect of spatial plasma nonuniformity on absolute parametric instability (API) of electrostatic waves in magnetized plane waveguides subjected to an intense high-frequency (HF) electric field using the separation method. In this case the effect of strong static magnetic field is ...

  12. Absolute parametric instability in a nonuniform plane plasma

    Indian Academy of Sciences (India)

    The paper reports an analysis of the effect of spatial plasma nonuniformity on absolute parametric instability (API) of electrostatic waves in magnetized plane waveguides subjected to an intense high-frequency (HF) electric field using the separation method. In this case the effect of strong static magnetic field is considered.

  13. Processing of optical combs with fiber optic parametric amplifiers

    Czech Academy of Sciences Publication Activity Database

    Slavík, Radan; Kakande, J.; Richardson, D.J.; Petropoulos, P.

    2012-01-01

    Roč. 20, č. 9 (2012), s. 10059-10070 ISSN 1094-4087 Institutional support: RVO:67985882 Keywords : Fiber -optic parametric amplifier * Phase sensitive * Spectral coverage Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 3.546, year: 2012

  14. Probing the dynamics of dark energy with novel parametrizations

    International Nuclear Information System (INIS)

    Ma Jingzhe; Zhang Xin

    2011-01-01

    We point out that the CPL parametrization has a problem that the equation of state w(z) diverges in the far future, so that this model can only properly describe the past evolution but cannot depict the future evolution. To overcome such a difficulty, in this Letter we propose two novel parametrizations for dark energy, the logarithm form w(z)=w 0 +w 1 ((ln(2+z))/(1+z) -ln2) and the oscillating form w(z)=w 0 +w 1 ((sin(1+z))/(1+z) -sin(1)), successfully avoiding the future divergency problem in the CPL parametrization, and use them to probe the dynamics of dark energy in the whole evolutionary history. Our divergency-free parametrizations are proven to be very successful in exploring the dynamical evolution of dark energy and have powerful prediction capability for the ultimate fate of the universe. Constraining the CPL model and the new models with the current observational data, we show that the new models are more favored. The features and the predictions for the future evolution in the new models are discussed in detail.

  15. Determinant of flexible Parametric Estimation of Mixture Cure ...

    African Journals Online (AJOL)

    AIC, mean time to cure), variance and cure fraction (c) were used to determine the flexible Parametric Cure Fraction Model among the considered models. Gastric Cancer data from 76 patients received adjuvant CRT and 125 receiving resection (surgery) alone were used to confirm the suitability of the models. The data was ...

  16. Parametric amplification in a micro Coriolis mass flow sensor

    NARCIS (Netherlands)

    Groenesteijn, Jarno; Droogendijk, H.; Wiegerink, Remco J.; Lammerink, Theodorus S.J.; Lötters, Joost Conrad; Sanders, Remco G.P.; Krijnen, Gijsbertus J.M.

    2014-01-01

    We report on the application of parametric amplification to a micro Coriolis mass flow sensor. We demonstrate that this mechanism allows for reduction of the system's power dissipation while retaining sensitivity to flow. By reducing this power dissipation, less heat will be transferred to the fluid

  17. Parametric Roll - Risk Reduction through Real-time Detection

    DEFF Research Database (Denmark)

    Galeazzi, Roberto

    2014-01-01

    PAROLL is an innovative condition-monitoring system for the timely detection of parametric roll on merchant vessels. It has been invented and developed by the Technical University of Denmark. DNV GL and Wallenius Marine have supported the development and full-scale validation of this monitoring...

  18. Parametric resonance in the early Universe—a fitting analysis

    International Nuclear Information System (INIS)

    Figueroa, Daniel G.; Torrentí, Francisco

    2017-01-01

    Particle production via parametric resonance in the early Universe, is a non-perturbative, non-linear and out-of-equilibrium phenomenon. Although it is a well studied topic, whenever a new scenario exhibits parametric resonance, a full re-analysis is normally required. To avoid this tedious task, many works present often only a simplified linear treatment of the problem. In order to surpass this circumstance in the future, we provide a fitting analysis of parametric resonance through all its relevant stages: initial linear growth, non-linear evolution, and relaxation towards equilibrium. Using lattice simulations in an expanding grid in 3+1 dimensions, we parametrize the dynamics' outcome scanning over the relevant ingredients: role of the oscillatory field, particle coupling strength, initial conditions, and background expansion rate. We emphasize the inaccuracy of the linear calculation of the decay time of the oscillatory field, and propose a more appropriate definition of this scale based on the subsequent non-linear dynamics. We provide simple fits to the relevant time scales and particle energy fractions at each stage. Our fits can be applied to post-inflationary preheating scenarios, where the oscillatory field is the inflaton, or to spectator-field scenarios, where the oscillatory field can be e.g. a curvaton, or the Standard Model Higgs.

  19. Parametric dependences of momentum pinch and Prandtl number in JET

    NARCIS (Netherlands)

    Tala, T.; Salmi, A.; Angioni, C.; Casson, F. J.; Corrigan, G.; Ferreira, J.; Giroud, C.; Mantica, P.; Naulin, V.; Peeters, A.G.; Solomon, W. M.; Strintzi, D.; Tsalas, M.; Versloot, T. W.; de Vries, P. C.; Zastrow, K. D.

    2011-01-01

    Several parametric scans have been performed to study momentum transport on JET. A neutral beam injection modulation technique has been applied to separate the diffusive and convective momentum transport terms. The magnitude of the inward momentum pinch depends strongly on the inverse density

  20. Spiral intensity patterns in the internally pumped optical parametric oscillator

    DEFF Research Database (Denmark)

    Lodahl, Peter; Bache, Morten; Saffman, Mark

    2001-01-01

    We describe a nonlinear optical system that supports spiral pattern solutions in the field intensity. This new spatial structure is found to bifurcate above a secondary instability in the internally pumped optical parametric oscillator. The analytical predictions of threshold and spatial scale...