Improvement of activated carbons as oxygen reduction catalysts in neutral solutions by ammonia gas treatment and their performance in microbial fuel cells

KAUST Repository

Watson, Valerie J.; Nieto Delgado, Cesar; Logan, Bruce E.

2013-01-01

Commercially available activated carbon (AC) powders from different precursor materials (peat, coconut shell, coal, and hardwood) were treated with ammonia gas at 700 C to improve their performance as oxygen reduction catalysts in neutral p

Quantifying the combined effects of pronase and benzalkonium chloride in removing late-stage Listeria monocytogenes-Escherichia coli dual-species biofilms.

Science.gov (United States)

Rodríguez-López, Pedro; Puga, Carmen H; Orgaz, Belén; Cabo, Marta L

2017-09-01

This work presents the assessment of the effectivity of a pronase (PRN)-benzalkonium chloride (BAC) sequential treatment in removing Listeria monocytogenes-Escherichia coli dual-species biofilms grown on stainless steel (SS) using fluorescence microscopy and plate count assays. The effects of PRN-BAC on the occupied area (OA) by undamaged cells in 168 h dual-species samples were determined using a first-order factorial design. Empirical equations significantly (r 2 = 0.927) described a negative individual effect of BAC and a negative interactive effect of PRN-BAC achieving OA reductions up to 46%. After treatment, high numbers of remaining attached and released viable and cultivable E. coli cells were detected in PRN-BAC combinations when low BAC concentrations were used. Therefore, at appropriate BAC doses, in addition to biofilm removal, sequential application of PRN and BAC represents an appealing strategy for pathogen control on SS surfaces while hindering the dispersion of live cells into the environment.

Electrochemical Reduction of Oxygen on Anthraquinone/Carbon Nanotubes Nanohybrid Modified Glassy Carbon Electrode in Neutral Medium

Directory of Open Access Journals (Sweden)

Zheng Gong

2013-01-01

Full Text Available The electrochemical behaviors of monohydroxy-anthraquinone/multiwall carbon nanotubes (MHAQ/MWCNTs nanohybrid modified glassy carbon (MHAQ/MWCNTs/GC electrodes in neutral medium were investigated; also reported was their application in the electrocatalysis of oxygen reduction reaction (ORR. The resulting MHAQ/MWCNTs nanohybrid was characterized by scanning electron microscope (SEM and transmission electron microscope (TEM. It was found that the ORR at the MHAQ/MWCNTs/GC electrode occurs irreversibly at a potential about 214 mV less negative than at a bare GC electrode in pH 7.0 buffer solution. Cyclic voltammetric and rotating disk electrode (RDE techniques indicated that the MHAQ/MWCNTs nanohybrid has high electrocatalytic activity for the two-electron reduction of oxygen in the studied potential range. The kinetic parameters of ORR at the MHAQ/MWCNTs nanohybrid modified GC electrode were also determined by RDE and EIS techniques.

Significant advantages of sulfur-doped graphene in neutral media as electrocatalyst for oxygen reduction comparing with Pt/C

Science.gov (United States)

Shi, Xinxin; Zhang, Jiaona; Huang, Tinglin

2018-02-01

Sulfur-doped graphene (SDG) has been found to be an efficient electrocatalyst for oxygen reduction reaction. However, previous studies on the catalytic activity of SDG have been mainly confined to O2-saturated alkaline media which is a typical alkaline fuel cell environment. Air-cathode microbial fuel cells (ACMFCs), as a novel energy conversion and wastewater treatment technology, use the oxygen from air as cathodic reactant in neutral media with low concentration of O2. Thus, it is meaningful to explore the catalytic performance of SDG in such ACMFC environment. The result showed that in ACMFC environment, the peak current density of SDG in CV test was surprisingly 4.5 times higher than that of Pt/C, indicating a much stronger catalytic activity of SDG. Moreover, SDG exhibited a stronger tolerance against the crossover of glucose (a typical anodic fuel in ACMFC) and better stability than Pt/C in neutral media.

Tolerance development in Listeria monocytogenes-Escherichia coli dual-species biofilms after sublethal exposures to pronase-benzalkonium chloride combined treatments.

Science.gov (United States)

Rodríguez-López, Pedro; Cabo, Marta López

2017-10-01

This study was designed to assess the effects that sublethal exposures to pronase (PRN) and benzalkonium chloride (BAC) combined treatments have on Listeria monocytogenes-Escherichia coli dual-species biofilms grown on stainless steel in terms of tolerance development (TD) to these compounds. Additionally, fluorescence microscopy was used to observe the changes of the biofilm structure. PRN-BAC exposure was carried out using three different approaches and TD was evaluated treating biofilms with a final 100 μg/ml PRN followed by 50 μg/ml BAC combined treatment. Results showed that exposure to PRN-BAC significantly decreased the number of adhered L. monocytogenes (P reduction values were generally lower in L. monocytogenes compared to E. coli. Additionally, microscopy images showed an altered morphology produced by sublethal PRN-BAC in exposed L. monocytogenes-E. coli dual-species biofilms compared to control samples. Results also demonstrated that L. monocytogenes-E. coli dual-species biofilms are able to develop tolerance to PRN-BAC combined treatments depending on way they have been previously exposed. Moreover, they suggest that the generation of bacterial tolerance should be included as a parameter for sanitation procedures design. Copyright © 2017 Elsevier Ltd. All rights reserved.

Improvement of activated carbons as oxygen reduction catalysts in neutral solutions by ammonia gas treatment and their performance in microbial fuel cells

KAUST Repository

Watson, Valerie J.

2013-11-01

Commercially available activated carbon (AC) powders from different precursor materials (peat, coconut shell, coal, and hardwood) were treated with ammonia gas at 700 C to improve their performance as oxygen reduction catalysts in neutral pH solutions used in microbial fuel cells (MFCs). The ammonia treated ACs exhibited better catalytic performance in rotating ring-disk electrode tests than their untreated precursors, with the bituminous based AC most improved, with an onset potential of Eonset = 0.12 V (untreated, Eonset = 0.08 V) and n = 3.9 electrons transferred in oxygen reduction (untreated, n = 3.6), and the hardwood based AC (treated, E onset = 0.03 V, n = 3.3; untreated, Eonset = -0.04 V, n = 3.0). Ammonia treatment decreased oxygen content by 29-58%, increased nitrogen content to 1.8 atomic %, and increased the basicity of the bituminous, peat, and hardwood ACs. The treated coal based AC cathodes had higher maximum power densities in MFCs (2450 ± 40 mW m-2) than the other AC cathodes or a Pt/C cathode (2100 ± 1 mW m-2). These results show that reduced oxygen abundance and increased nitrogen functionalities on the AC surface can increase catalytic performance for oxygen reduction in neutral media. © 2013 Elsevier B.V. All rights reserved.

Mutual Coupling Reduction for UWB MIMO Antennas with a Wideband Neutralization Line

DEFF Research Database (Denmark)

Zhang, Shuai; Pedersen, Gert F.

2016-01-01

A wideband neutralization line is proposed to reduce the mutual coupling of a compact ultrawideband (UWB) MIMO antenna. With the introduced decoupling method, the designed UWB MIMO antenna covers the band of 3.1-5 GHz with an isolation of higher than 22 dB. The proposed wideband neutralization line...

Automated image-based assay for evaluation of HIV neutralization and cell-to-cell fusion inhibition.

Science.gov (United States)

Sheik-Khalil, Enas; Bray, Mark-Anthony; Özkaya Şahin, Gülsen; Scarlatti, Gabriella; Jansson, Marianne; Carpenter, Anne E; Fenyö, Eva Maria

2014-08-30

Standardized techniques to detect HIV-neutralizing antibody responses are of great importance in the search for an HIV vaccine. Here, we present a high-throughput, high-content automated plaque reduction (APR) assay based on automated microscopy and image analysis that allows evaluation of neutralization and inhibition of cell-cell fusion within the same assay. Neutralization of virus particles is measured as a reduction in the number of fluorescent plaques, and inhibition of cell-cell fusion as a reduction in plaque area. We found neutralization strength to be a significant factor in the ability of virus to form syncytia. Further, we introduce the inhibitory concentration of plaque area reduction (ICpar) as an additional measure of antiviral activity, i.e. fusion inhibition. We present an automated image based high-throughput, high-content HIV plaque reduction assay. This allows, for the first time, simultaneous evaluation of neutralization and inhibition of cell-cell fusion within the same assay, by quantifying the reduction in number of plaques and mean plaque area, respectively. Inhibition of cell-to-cell fusion requires higher quantities of inhibitory reagent than inhibition of virus neutralization.

BEAMS3D Neutral Beam Injection Model

Energy Technology Data Exchange (ETDEWEB)

Lazerson, Samuel

2014-04-14

With the advent of applied 3D fi elds in Tokamaks and modern high performance stellarators, a need has arisen to address non-axisymmetric effects on neutral beam heating and fueling. We report on the development of a fully 3D neutral beam injection (NBI) model, BEAMS3D, which addresses this need by coupling 3D equilibria to a guiding center code capable of modeling neutral and charged particle trajectories across the separatrix and into the plasma core. Ionization, neutralization, charge-exchange, viscous velocity reduction, and pitch angle scattering are modeled with the ADAS atomic physics database [1]. Benchmark calculations are presented to validate the collisionless particle orbits, neutral beam injection model, frictional drag, and pitch angle scattering effects. A calculation of neutral beam heating in the NCSX device is performed, highlighting the capability of the code to handle 3D magnetic fields.

Rapid evolution of troglomorphic characters suggests selection rather than neutral mutation as a driver of eye reduction in cave crabs.

Science.gov (United States)

Klaus, Sebastian; Mendoza, José C E; Liew, Jia Huan; Plath, Martin; Meier, Rudolf; Yeo, Darren C J

2013-04-23

This study asked whether reductive traits in cave organisms evolve at a slower pace (suggesting neutral evolution under relaxed selection) than constructive changes, which are likely to evolve under directional selection. We investigated 11 subterranean and seven surface populations of Sundathelphusa freshwater crabs on Bohol Island, Philippines, and examined constructive traits associated with improved food finding in darkness (increased leg and setae length) and reductive traits (reduced cornea size and eyestalk length). All changes occurred rapidly, given that the age of the most recent common ancestor was estimated to be 722-271 ka based on three mitochondrial markers. In order to quantify the speed of character change, we correlated the degree of morphological change with genetic distances between surface and subterranean individuals. The temporal pattern of character change following the transition to subterranean life was indistinguishable for constructive and reductive traits, characterized by an immediate onset and rapid evolutionary change. We propose that the evolution of these reductive traits-just like constructive traits-is most likely driven by strong directional selection.

The significance for epidemiological studies anti-measles antibody detection examined by enzyme immunoassay (EIA) and plaque reduction neutralization test (PRNT).

Science.gov (United States)

Siennicka, Joanna; Częścik, Agnieszka; Trzcińska, Agnieszka

2014-01-01

The paper discusses the role of anti-measles antibodies for protection and significance for epidemiological studies determination of antibodies by different serological methods. The comparison of anti-measles virus antibodies levels measured by enzyme immunoassay (EIA) and Plaque Reduction Neutralization Test (PRNT) was described. It was found that the 200 mIU/ml of anti-measles activity measured by PRNT (level protection against symp- tomatic disease) is equivalent of 636 mIU/ml measured by EIA (Enzygnost®Anti-Measles Virus/IgG, Simens).

A novel approach in red mud neutralization using cow dung.

Science.gov (United States)

Patel, Sucharita; Pal, Bhatu Kumar; Patel, Raj Kishore

2018-05-01

In this study, cow dung was identified as a neutralizing agent for red mud (RM). Present research estimated a significant reduction in pH value of red mud (10 g) from 10.28 to 8.15 and reduction in alkalinity of ~148 mg/L from ~488 mg/L by adding 80 g of cow dung in 40 days of anaerobic condition. XRD results exhibit a high intensity of quartz and found new compound, the calcium carbide. The acid neutralizing capacity (ANC) of NRM reduces to ~0.87 from ~1.506 mol H + /kg. Based on the resultant research, present study proposes cow dung as an efficient neutralizing agent for reducing the pH and alkalinity in the red mud.

The control of powerful neutral beams

International Nuclear Information System (INIS)

Theil, E.; Jacobson, V.

1986-01-01

While significant progress has been made in the development of neutral beams for the heating and sustaining of plasmas in large fusion experiments, the control of such devices has largely been a matter of hardware interlocks and operator experience. The need for computer-assisted control becomes more evident, however, with the initiation of multi-beamline experiments. This paper describes a software system that incorporates simple mathematical models coupled to Kalman filters for control of the high power (6 to 8 MW) beams currently under development at Lawrence Berkeley Laboratory's Neutral Beam Engineering Test Facility. Among the principal features of the system are: reduction of a large number of operator variables to just a few (usually one or two); the ability to describe most of the major neutral beams in use and under development; a foundation resting on statistical data analysis and control system principles rather than rules-of-thumb

Nitrogen-neutrality: a step towards sustainability

Science.gov (United States)

Leip, Adrian; Leach, Allison; Musinguzi, Patrick; Tumwesigye, Trust; Olupot, Giregon; Tenywa, John Stephen; Mudiope, Joseph; Hutton, Olivia; Cordovil, Claudia M. d. S.; Bekunda, Mateete; Galloway, James

2014-11-01

We propose a novel indicator measuring one dimension of the sustainability of an entity in modern societies: Nitrogen-neutrality. N-neutrality strives to offset Nr releases an entity exerts on the environment from the release of reactive nitrogen (Nr) to the environment by reducing it and by offsetting the Nr releases elsewhere. N-neutrality also aims to increase awareness about the consequences of unintentional releases of nitrogen to the environment. N-neutrality is composed of two quantified elements: Nr released by an entity (e.g. on the basis of the N footprint) and Nr reduction from management and offset projects (N offset). It includes management strategies to reduce nitrogen losses before they occur (e.g., through energy conservation). Each of those elements faces specific challenges with regard to data availability and conceptual development. Impacts of Nr releases to the environment are manifold, and the impact profile of one unit of Nr release depends strongly on the compound released and the local susceptibility to Nr. As such, N-neutrality is more difficult to conceptualize and calculate than C-neutrality. We developed a workable conceptual framework for N-neutrality which was adapted for the 6th International Nitrogen Conference (N2013, Kampala, November 2013). Total N footprint of the surveyed meals at N2013 was 66 kg N. A total of US 3050 was collected from the participants and used to offset the conference’s N footprint by supporting the UN Millennium Village cluster Ruhiira in South-Western Uganda. The concept needs further development in particular to better incorporate the spatio-temporal variability of impacts and to standardize the methods to quantify the required N offset to neutralize the Nr releases impact. Criteria for compensation projects need to be sharply defined to allow the development of a market for N offset certificates.

Nitrogen-neutrality: a step towards sustainability

International Nuclear Information System (INIS)

Leip, Adrian; Leach, Allison; Hutton, Olivia; Galloway, James; Musinguzi, Patrick; Tumwesigye, Trust; Olupot, Giregon; Stephen Tenywa, John; Mudiope, Joseph; Cordovil, Claudia M d S; Bekunda, Mateete

2014-01-01

We propose a novel indicator measuring one dimension of the sustainability of an entity in modern societies: Nitrogen-neutrality. N-neutrality strives to offset Nr releases an entity exerts on the environment from the release of reactive nitrogen (Nr) to the environment by reducing it and by offsetting the Nr releases elsewhere. N-neutrality also aims to increase awareness about the consequences of unintentional releases of nitrogen to the environment. N-neutrality is composed of two quantified elements: Nr released by an entity (e.g. on the basis of the N footprint) and Nr reduction from management and offset projects (N offset). It includes management strategies to reduce nitrogen losses before they occur (e.g., through energy conservation). Each of those elements faces specific challenges with regard to data availability and conceptual development. Impacts of Nr releases to the environment are manifold, and the impact profile of one unit of Nr release depends strongly on the compound released and the local susceptibility to Nr. As such, N-neutrality is more difficult to conceptualize and calculate than C-neutrality. We developed a workable conceptual framework for N-neutrality which was adapted for the 6th International Nitrogen Conference (N2013, Kampala, November 2013). Total N footprint of the surveyed meals at N2013 was 66 kg N. A total of US$ 3050 was collected from the participants and used to offset the conference’s N footprint by supporting the UN Millennium Village cluster Ruhiira in South-Western Uganda. The concept needs further development in particular to better incorporate the spatio-temporal variability of impacts and to standardize the methods to quantify the required N offset to neutralize the Nr releases impact. Criteria for compensation projects need to be sharply defined to allow the development of a market for N offset certificates. (paper)

Assaying Cellular Viability Using the Neutral Red Uptake Assay.

Science.gov (United States)

Ates, Gamze; Vanhaecke, Tamara; Rogiers, Vera; Rodrigues, Robim M

2017-01-01

The neutral red uptake assay is a cell viability assay that allows in vitro quantification of xenobiotic-induced cytotoxicity. The assay relies on the ability of living cells to incorporate and bind neutral red, a weak cationic dye, in lysosomes. As such, cytotoxicity is expressed as a concentration-dependent reduction of the uptake of neutral red after exposure to the xenobiotic under investigation. The neutral red uptake assay is mainly used for hazard assessment in in vitro toxicology applications. This method has also been introduced in regulatory recommendations as part of 3T3-NRU-phototoxicity-assay, which was regulatory accepted in all EU member states in 2000 and in the OECD member states in 2004 as a test guideline (TG 432). The present protocol describes the neutral red uptake assay using the human hepatoma cell line HepG2, which is often employed as an alternative in vitro model for human hepatocytes. As an example, the cytotoxicity of acetaminophen and acetyl salicylic acid is assessed.

Are "Market Neutral" Hedge Funds Really Market Neutral?

OpenAIRE

Andrew J. Patton

2009-01-01

Using a variety of different definitions of "neutrality," this study presents significant evidence against the neutrality to market risk of hedge funds in a range of style categories. I generalize standard definitions of "market neutrality," and propose five different neutrality concepts. I suggest statistical tests for each neutrality concept, and apply these tests to a database of monthly returns on 1423 hedge funds from five style categories. For the "market neutral" style, approximately o...

Neutral and plasma shielding model for pellet ablation

International Nuclear Information System (INIS)

Houlberg, W.A.; Milora, S.L.; Attenberger, S.E.

1987-10-01

The neutral gas shielding model for ablation of frozen hydrogenic pellets is extended to include the effects of an initial Maxwelliam distribution of incident electron energies; a cold plasma shield outside the neutral shield and extended along the magnetic field; energetic neutral beam ions and alpha particles; and self-limiting electron ablation in the collisionless plasma limit. Including the full electron distribution increases ablation, but adding the cold ionized shield reduces ablation; the net effect is a modest reduction in pellet penetration compared with the monoenergetic electron neutral shielding model with no plasma shield. Unlike electrons, fast ions can enter the neutral shield directly without passing through the cold ionized shield because their gyro-orbits are typically larger than the diameter of the cold plasma tube. Fast alpha particles should not enhance the ablation rate unless their population exceeds that expected from local classical thermalization. Fast beam ions, however, may enhance ablation in the plasma periphery if their population is high enough. Self-limiting ablation in the collisionless limit leads to a temporary distortion of the original plasma electron Maxwellian distribution function through preferential depopulation of the higher-energy electrons. 23 refs., 9 figs

DISSOLVED OXYGEN REDUCTION IN THE DIII-D NEUTRAL BEAM ION SOURCE COOLING SYSTEM

International Nuclear Information System (INIS)

YIP, H.; BUSATH, J.; HARRISON, S.

2004-03-01

OAK-B135 Neutral beam ion sources (NBIS) are critical components for the neutral beam injection system supporting the DIII-D tokamak. The NBIS must be cooled with 3028 (ell)/m (800 gpm) of de-ionized and de-oxygenated water to protect the sources from overheating and failure. These ions sources are currently irreplaceable. Since the water cooled molybdenum components will oxidize in water almost instantaneously in the presence of dissolved oxygen (DO), de-oxygenation is extremely important in the NBIS water system. Under normal beam operation the DO level is kept below 5 ppb. However, during weeknights and weekends when neutral beam is not in operation, the average DO level is maintained below 10 ppb by periodic circulation with a 74.6 kW (100 hp) pump, which consumes significant power. Experimental data indicated evidence of continuous oxygen diffusion through non-metallic hoses in the proximity of the NBIS. Because of the intermittent flow of the cooling water, the DO concentration at the ion source(s) could be even higher than measured downstream, and hence the concern of significant localized oxidation/corrosion. A new 3.73 kW (5 hp) auxiliary system, installed in the summer of 2003, is designed to significantly reduce the peak and the time-average DO levels in the water system and to consume only a fraction of the power

Oblique non-neutral solitary Alfven modes in weakly nonlinear pair plasmas

International Nuclear Information System (INIS)

Verheest, Frank; Lakhina, G S

2005-01-01

The equal charge-to-mass ratio for both species in pair plasmas induces a decoupling of the linear eigenmodes between waves that are charge neutral or non-neutral, also at oblique propagation with respect to a static magnetic field. While the charge-neutral linear modes have been studied in greater detail, including their weakly and strongly nonlinear counterparts, the non-neutral mode has received less attention. Here the nonlinear evolution of a solitary non-neutral mode at oblique propagation is investigated in an electron-positron plasma. Employing the framework of reductive perturbation analysis, a modified Korteweg-de Vries equation (with cubic nonlinearity) for the lowest-order wave magnetic field is obtained. In the linear approximation, the non-neutral mode has its magnetic component orthogonal to the plane spanned by the directions of wave propagation and of the static magnetic field. The linear polarization is not maintained at higher orders. The results may be relevant to the microstructure in pulsar radiation or to the subpulses

Modeling neutralization kinetics of HIV by broadly neutralizing monoclonal antibodies in genital secretions coating the cervicovaginal mucosa.

Directory of Open Access Journals (Sweden)

Scott A McKinley

Full Text Available Eliciting broadly neutralizing antibodies (bnAb in cervicovaginal mucus (CVM represents a promising "first line of defense" strategy to reduce vaginal HIV transmission. However, it remains unclear what levels of bnAb must be present in CVM to effectively reduce infection. We approached this complex question by modeling the dynamic tally of bnAb coverage on HIV. This analysis introduces a critical, timescale-dependent competition: to protect, bnAb must accumulate at sufficient stoichiometry to neutralize HIV faster than virions penetrate CVM and reach target cells. We developed a model that incorporates concentrations and diffusivities of HIV and bnAb in semen and CVM, kinetic rates for binding (kon and unbinding (koff of select bnAb, and physiologically relevant thicknesses of CVM and semen layers. Comprehensive model simulations lead to robust conclusions about neutralization kinetics in CVM. First, due to the limited time virions in semen need to penetrate CVM, substantially greater bnAb concentrations than in vitro estimates must be present in CVM to neutralize HIV. Second, the model predicts that bnAb with more rapid kon, almost independent of koff, should offer greater neutralization potency in vivo. These findings suggest the fastest arriving virions at target cells present the greatest likelihood of infection. It also implies the marked improvements in in vitro neutralization potency of many recently discovered bnAb may not translate to comparable reduction in the bnAb dose needed to confer protection against initial vaginal infections. Our modeling framework offers a valuable tool to gaining quantitative insights into the dynamics of mucosal immunity against HIV and other infectious diseases.

Modeling neutralization kinetics of HIV by broadly neutralizing monoclonal antibodies in genital secretions coating the cervicovaginal mucosa.

Science.gov (United States)

McKinley, Scott A; Chen, Alex; Shi, Feng; Wang, Simi; Mucha, Peter J; Forest, M Gregory; Lai, Samuel K

2014-01-01

Eliciting broadly neutralizing antibodies (bnAb) in cervicovaginal mucus (CVM) represents a promising "first line of defense" strategy to reduce vaginal HIV transmission. However, it remains unclear what levels of bnAb must be present in CVM to effectively reduce infection. We approached this complex question by modeling the dynamic tally of bnAb coverage on HIV. This analysis introduces a critical, timescale-dependent competition: to protect, bnAb must accumulate at sufficient stoichiometry to neutralize HIV faster than virions penetrate CVM and reach target cells. We developed a model that incorporates concentrations and diffusivities of HIV and bnAb in semen and CVM, kinetic rates for binding (kon) and unbinding (koff) of select bnAb, and physiologically relevant thicknesses of CVM and semen layers. Comprehensive model simulations lead to robust conclusions about neutralization kinetics in CVM. First, due to the limited time virions in semen need to penetrate CVM, substantially greater bnAb concentrations than in vitro estimates must be present in CVM to neutralize HIV. Second, the model predicts that bnAb with more rapid kon, almost independent of koff, should offer greater neutralization potency in vivo. These findings suggest the fastest arriving virions at target cells present the greatest likelihood of infection. It also implies the marked improvements in in vitro neutralization potency of many recently discovered bnAb may not translate to comparable reduction in the bnAb dose needed to confer protection against initial vaginal infections. Our modeling framework offers a valuable tool to gaining quantitative insights into the dynamics of mucosal immunity against HIV and other infectious diseases.

Reduction of ion thermal diffusivity associated with the transition of the radial electric field in neutral-beam-heated plasmas in the large helical device.

Science.gov (United States)

Ida, K; Funaba, H; Kado, S; Narihara, K; Tanaka, K; Takeiri, Y; Nakamura, Y; Ohyabu, N; Yamazaki, K; Yokoyama, M; Murakami, S; Ashikawa, N; deVries, P C; Emoto, M; Goto, M; Idei, H; Ikeda, K; Inagaki, S; Inoue, N; Isobe, M; Itoh, K; Kaneko, O; Kawahata, K; Khlopenkov, K; Komori, A; Kubo, S; Kumazawa, R; Liang, Y; Masuzaki, S; Minami, T; Miyazawa, J; Morisaki, T; Morita, S; Mutoh, T; Muto, S; Nagayama, Y; Nakanishi, H; Nishimura, K; Noda, N; Notake, T; Kobuchi, T; Ohdachi, S; Ohkubo, K; Oka, Y; Osakabe, M; Ozaki, T; Pavlichenko, R O; Peterson, B J; Sagara, A; Saito, K; Sakakibara, S; Sakamoto, R; Sanuki, H; Sasao, H; Sasao, M; Sato, K; Sato, M; Seki, T; Shimozuma, T; Shoji, M; Suzuki, H; Sudo, S; Tamura, N; Toi, K; Tokuzawa, T; Torii, Y; Tsumori, K; Yamamoto, T; Yamada, H; Yamada, I; Yamaguchi, S; Yamamoto, S; Yoshimura, Y; Watanabe, K Y; Watari, T; Hamada, Y; Motojima, O; Fujiwara, M

2001-06-04

Recent large helical device experiments revealed that the transition from ion root to electron root occurred for the first time in neutral-beam-heated discharges, where no nonthermal electrons exist. The measured values of the radial electric field were found to be in qualitative agreement with those estimated by neoclassical theory. A clear reduction of ion thermal diffusivity was observed after the mode transition from ion root to electron root as predicted by neoclassical theory when the neoclassical ion loss is more dominant than the anomalous ion loss.

Temporal behavior of neutral particle fluxes in TFTR [Tokamak Fusion Test Reactor] neutral beam injectors

International Nuclear Information System (INIS)

Kamperschroer, J.H.; Gammel, G.M.; Roquemore, A.L.

1989-09-01

Data from an E parallel B charge exchange neutral analyzer (CENA), which views down the axis of a neutral beamline through an aperture in the target chamber calorimeter of the TFTR neutral beam test facility, exhibit two curious effects. First, there is a turn-on transient lasting tens of milliseconds having a magnitude up to three times that of the steady-state level. Second, there is a 720 Hz, up to 20% peak-to-peak fluctuation persisting the entire pulse duration. The turn-on transient occurs as the neutralizer/ion source system reaches a new pressure equilibrium following the effective ion source gas throughput reduction by particle removal as ion beam. Widths of the transient are a function of the gas throughput into the ion source, decreasing as the gas supply rate is reduced. Heating of the neutalizer gas by the beam is assumed responsible, with gas temperature increasing as gas supply rate is decreased. At low gas supply rates, the transient is primarliy due to dynamic changes in the neutralizer line density and/or beam species composition. Light emission from the drift duct corroborate the CENA data. At high gas supply rates, dynamic changes in component divergence and/or spatial profiles of the source plasma are necessary to explain the observations. The 720 Hz fluctuation is attributed to a 3% peak-to-peak ripple of 720 Hz on the arc power supply amplified by the quadratic relationship between beam divergence and beam current. Tight collimation by CENA apertures cause it to accept a very small part of the ion source's velocity space, producing a signal linearly proportional to beam divergence. Estimated fluctuations in the peak power density delivered to the plasma under these conditions are a modest 3--8% peak to peak. The efffects of both phenomena on the injected neutral beam can be ameliorated by careful operion of the ion sources. 21 refs., 11 figs., 2 tabs

''Econodump'' design for the Fermilab Direct Neutral Lepton Facility

International Nuclear Information System (INIS)

Childress, S.; Brown, C.; Koizumi, G.; Malensek, A.; Morfin, J.G.; Murphy, T.; Stefanski, R.; Wehman, A.; Lu, B.

1986-08-01

An extensive effort has been directed toward a major redesign of the Fermilab Direct Neutral Lepton Facility (DNLF). The goal has been a very significant cost reduction of the facility, with minimal sacrifice of physics potential. Hence the name ''Econodump'' applied to the redesign effort

Initiatives towards Carbon Neutrality in the Helsinki Metropolitan Area

Directory of Open Access Journals (Sweden)

Karna Dahal

2016-07-01

Full Text Available Carbon neutrality represents one climate strategy adopted by many cities, including the city of Helsinki and the Helsinki metropolitan area in Finland. This study examines initiatives adopted by the Helsinki metropolitan area aimed at reducing energy-related carbon emissions and achieving carbon neutrality through future actions. Various sectorial energy consumption rates per year and carbon emissions from various sectors within the city of Helsinki and the metropolitan area were extracted from an online database and re-calculated (in GWh, MWh/inhabitant and MtCO2e, KtCO2e/inhabitant. We employed a backcasting scenario method to explore the various carbon reduction measures in the Helsinki metropolitan area. About 96% of the emissions produced in the Helsinki metropolitan area are energy-based. District heating represents the primary source of emissions, followed by transportation and electricity consumption, respectively. We also found that accomplishing the carbon reduction strategies of the Helsinki metropolitan area by 2050 remains challenging. Technological advancement for clean and renewable energy sources, smart policies and raising awareness resulting in behavioral changes greatly affect carbon reduction actions. Thus, strong political commitments are also required to formulate and implement stringent climate actions.

Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells.

Science.gov (United States)

Cohen, Yehuda Z; Lorenzi, Julio C C; Seaman, Michael S; Nogueira, Lilian; Schoofs, Till; Krassnig, Lisa; Butler, Allison; Millard, Katrina; Fitzsimons, Tomas; Daniell, Xiaoju; Dizon, Juan P; Shimeliovich, Irina; Montefiori, David C; Caskey, Marina; Nussenzweig, Michel C

2018-03-01

HIV-1 epidemic. Antibodies with exceptional neutralizing activity against HIV-1 may provide several advantages to traditional HIV drugs, including an improved side-effect profile, a reduced dosing frequency, and immune enhancement. The activity of these antibodies has been established in vitro by utilizing HIV-1 Env-pseudotyped viruses derived from circulating viruses but produced in 293T cells by pairing Env proteins with a backbone vector. We tested PBMC-produced circulating viruses against five anti-HIV-1 antibodies currently in clinical development. We found that the activity of these antibodies against PBMC isolates is significantly less than that against 293T Env-pseudotyped viruses. This decline varied among the antibodies tested, with some demonstrating moderate reductions in activity and others showing an almost 100-fold reduction. As the development of these antibodies progresses, it will be critical to determine how the results of different in vitro tests correspond to performance in the clinic. Copyright © 2018 Cohen et al.

Automation of multiple neutral beam injector controls at Lawrence Livermore Laboratory

International Nuclear Information System (INIS)

Pollock, G.G.

1977-01-01

The computer control system used on the twelve Neutral Beams of the 2XIIB experiment at the Lawrence Livermore Laboratory (LLL) has evolved over the last three years. It is now in its final form and in regular use. It provides automatic data collection, reduction, and graphics presentation, as well as automatic conditioning, automatic normal operation, and processing of calorimeter data. This paper presents an overview of the capabilities and implementation of the current system, a detailed discussion of the automatic conditioning algorithm, and discusses the future directions for neutral beam automation

Neutral Color Semitransparent Microstructured Perovskite Solar Cells

KAUST Repository

Eperon, Giles E.

2014-01-28

Neutral-colored semitransparent solar cells are commercially desired to integrate solar cells into the windows and cladding of buildings and automotive applications. Here, we report the use of morphological control of perovskite thin films to form semitransparent planar heterojunction solar cells with neutral color and comparatively high efficiencies. We take advantage of spontaneous dewetting to create microstructured arrays of perovskite "islands", on a length-scale small enough to appear continuous to the eye yet large enough to enable unattenuated transmission of light between the islands. The islands are thick enough to absorb most visible light, and the combination of completely absorbing and completely transparent regions results in neutral transmission of light. Using these films, we fabricate thin-film solar cells with respectable power conversion efficiencies. Remarkably, we find that such discontinuous films still have good rectification behavior and relatively high open-circuit voltages due to the inherent rectification between the n- and p-type charge collection layers. Furthermore, we demonstrate the ease of "color-tinting" such microstructured perovksite solar cells with no reduction in performance, by incorporation of a dye within the hole transport medium. © 2013 American Chemical Society.

Extreme late-summer drought causes neutral annual carbon balance in southwestern ponderosa pine forests and grasslands

International Nuclear Information System (INIS)

Kolb, Thomas; Dore, Sabina; Montes-Helu, Mario

2013-01-01

We assessed the impacts of extreme late-summer drought on carbon balance in a semi-arid forest region in Arizona. To understand drought impacts over extremes of forest cover, we measured net ecosystem production (NEP), gross primary production (GPP), and total ecosystem respiration (TER) with eddy covariance over five years (2006–10) at an undisturbed ponderosa pine (Pinus ponderosa) forest and at a former forest converted to grassland by intense burning. Drought shifted annual NEP from a weak source of carbon to the atmosphere to a neutral carbon balance at the burned site and from a carbon sink to neutral at the undisturbed site. Carbon fluxes were particularly sensitive to drought in August. Drought shifted August NEP at the undisturbed site from sink to source because the reduction of GPP (70%) exceeded the reduction of TER (35%). At the burned site drought shifted August NEP from weak source to neutral because the reduction of TER (40%) exceeded the reduction of GPP (20%). These results show that the lack of forest recovery after burning and the exposure of undisturbed forests to late-summer drought reduce carbon sink strength and illustrate the high vulnerability of forest carbon sink strength in the southwest US to predicted increases in intense burning and precipitation variability. (letter)

Extreme late-summer drought causes neutral annual carbon balance in southwestern ponderosa pine forests and grasslands

Science.gov (United States)

Kolb, Thomas; Dore, Sabina; Montes-Helu, Mario

2013-03-01

We assessed the impacts of extreme late-summer drought on carbon balance in a semi-arid forest region in Arizona. To understand drought impacts over extremes of forest cover, we measured net ecosystem production (NEP), gross primary production (GPP), and total ecosystem respiration (TER) with eddy covariance over five years (2006-10) at an undisturbed ponderosa pine (Pinus ponderosa) forest and at a former forest converted to grassland by intense burning. Drought shifted annual NEP from a weak source of carbon to the atmosphere to a neutral carbon balance at the burned site and from a carbon sink to neutral at the undisturbed site. Carbon fluxes were particularly sensitive to drought in August. Drought shifted August NEP at the undisturbed site from sink to source because the reduction of GPP (70%) exceeded the reduction of TER (35%). At the burned site drought shifted August NEP from weak source to neutral because the reduction of TER (40%) exceeded the reduction of GPP (20%). These results show that the lack of forest recovery after burning and the exposure of undisturbed forests to late-summer drought reduce carbon sink strength and illustrate the high vulnerability of forest carbon sink strength in the southwest US to predicted increases in intense burning and precipitation variability.

Boundary asymptotics for a non-neutral electrochemistry model with small Debye length

Science.gov (United States)

Lee, Chiun-Chang; Ryham, Rolf J.

2018-04-01

This article addresses the boundary asymptotics of the electrostatic potential in non-neutral electrochemistry models with small Debye length in bounded domains. Under standard physical assumptions motivated by non-electroneutral phenomena in oxidation-reduction reactions, we show that the electrostatic potential asymptotically blows up at boundary points with respect to the bulk reference potential as the scaled Debye length tends to zero. The analysis gives a lower bound for the blow-up rate with respect to the model parameters. Moreover, the maximum potential difference over any compact subset of the physical domain vanishes exponentially in the zero-Debye-length limit. The results mathematically confirm the physical description that electrolyte solutions are electrically neutral in the bulk and are strongly electrically non-neutral near charged surfaces.

Safety and immunogenicity of a combined Tetanus, Diphtheria, recombinant acellular Pertussis vaccine (TdaP) in healthy Thai adults.

Science.gov (United States)

Sirivichayakul, Chukiat; Chanthavanich, Pornthep; Limkittikul, Kriengsak; Siegrist, Claire-Anne; Wijagkanalan, Wassana; Chinwangso, Pailinrut; Petre, Jean; Hong Thai, Pham; Chauhan, Mukesh; Viviani, Simonetta

2017-01-02

An acellular Pertussis (aP) vaccine containing recombinant genetically detoxified Pertussis Toxin (PTgen), Filamentous Hemagglutinin (FHA) and Pertactin (PRN) has been developed by BioNet-Asia (BioNet). We present here the results of the first clinical study of this recombinant aP vaccine formulated alone or in combination with tetanus and diphtheria toxoids (TdaP). A phase I/II, observer-blind, randomized controlled trial was conducted at Mahidol University in Bangkok, Thailand in healthy adult volunteers aged 18-35 y. The eligible volunteers were randomized to receive one dose of either BioNet's aP or Tetanus toxoid-reduced Diphtheria toxoid-acellular Pertussis (TdaP) vaccine, or the Tdap Adacel® vaccine in a 1:1:1 ratio. Safety follow-up was performed for one month. Immunogenicity was assessed at baseline, at 7 and 28 d after vaccination. Anti-PT, anti-FHA, anti-PRN, anti-tetanus and anti-diphtheria IgG antibodies were assessed by ELISA. Anti-PT neutralizing antibodies were assessed also by CHO cell assay. A total of 60 subjects (20 per each vaccine group) were enrolled and included in the safety analysis. Safety laboratory parameters, incidence of local and systemic post-immunization reactions during 7 d after vaccination and incidence of adverse events during one month after vaccination were similar in the 3 vaccine groups. One month after vaccination, seroresponse rates of anti-PT, anti-FHA and anti-PRN IgG antibodies exceeded 78% in all vaccine groups. The anti-PT IgG, anti-FHA IgG, and anti-PT neutralizing antibody geometric mean titers (GMTs) were significantly higher following immunization with BioNet's aP and BioNet's TdaP than Adacel® (Pdiphtheria GMTs at one month after immunization were comparable in all vaccine groups. All subjects had seroprotective titers of anti-tetanus and anti-diphtheria antibodies at baseline. In this first clinical study, PTgen-based BioNet's aP and TdaP vaccines showed a similar tolerability and safety profile to Adacel

Climate Neutral Campus Key Terms and Definitions | Climate Neutral Research

Science.gov (United States)

Campuses | NREL Neutral Campus Key Terms and Definitions Climate Neutral Campus Key Terms and Definitions The term climate neutral evolved along with net zero and a number of other "green" and accuracy in these areas lets research campuses know exactly how close they are to climate

Global warming and social innovation. The challenge of a climate-neutral society

Energy Technology Data Exchange (ETDEWEB)

Kok, M.T.J.; Vermeulen, W.J.V.; Faaij, A.P.C.; De Jager, D. (eds.)

2002-07-01

After the introductory Chapter 1 Chapter 2 presents two long-term visions of a climate-neutral energy system in The Netherlands. It looks at the window of opportunity and shows that there are a number of technically feasible ways to realize drastic emission reductions. At the same time, it is well known that climate change is a tough problem to deal with and that the results of current policies have been relatively meagre. In Chapter 3 a number of dilemmas that play a role in current climate-change policies is identified. The dilemmas are elaborated in the light of desired long-term developments. Both Chapters 2 and 3 illustrate a sharp contrast between the problematic current situation and the substantial targets that need to be achieved over time. The question is how to realize trend breaks and orchestrate the transition towards a climate-neutral societal. In Chapter 4 the governance of technological change and innovation is discussed. Chapters 2, 3, and 4 form the basis on which the authors of the subsequent chapters have written their analysis about the transition towards a climate-neutral society. As a whole, the book provides the reader with an analysis of prospects of long-term climate policies, short-term issues, the societal trend breaks needed to realize substantive emission reductions and possible ways to realize these trend breaks. Chapter 5 analyses households, behaviour and consumption patterns. It assesses future opportunities for drastic changes that would lead to more environmentally sound energy consumption by households and discusses constraints to changes in behaviour. In Chapter 6, the role of local authorities in the transition to a climate-neutral society is discussed. Chapter 7 takes the perspective of materials management as a breakthrough technology for reducing greenhouse gas emissions. In Chapter 8, the contribution that information and communication technology (ICT) (as another breakthrough technology) can make to the transition is

Neutrality Versus Materiality: A Thermodynamic Theory of Neutral Surfaces

Directory of Open Access Journals (Sweden)

Rémi Tailleux

2016-09-01

Full Text Available In this paper, a theory for constructing quasi-neutral density variables γ directly in thermodynamic space is formulated, which is based on minimising the absolute value of a purely thermodynamic quantity J n . Physically, J n has a dual dynamic/thermodynamic interpretation as the quantity controlling the energy cost of adiabatic and isohaline parcel exchanges on material surfaces, as well as the dependence of in-situ density on spiciness, in a description of water masses based on γ, spiciness and pressure. Mathematically, minimising | J n | in thermodynamic space is showed to be equivalent to maximising neutrality in physical space. The physics of epineutral dispersion is also reviewed and discussed. It is argued, in particular, that epineutral dispersion is best understood as the aggregate effect of many individual non-neutral stirring events (being understood here as adiabatic and isohaline events with non-zero buoyancy, so that it is only the net displacement aggregated over many events that is approximately neutral. This new view resolves an apparent paradox between the focus in neutral density theory on zero-buoyancy motions and the overwhelming evidence that lateral dispersion in the ocean is primarily caused by non-zero buoyancy processes such as tides, residual currents and sheared internal waves. The efficiency by which a physical process contributes to lateral dispersion can be characterised by its energy signature, with those processes releasing available potential energy (negative energy cost being more efficient than purely neutral processes with zero energy cost. The latter mechanism occurs in the wedge of instability, and its source of energy is the coupling between baroclinicity, thermobaricity, and density compensated temperature/salinity anomalies. Such a mechanism, which can only exist in a salty ocean, is speculated to be important for dissipating spiciness anomalies and neutral helicity. The paper also discusses potential

Drug-related problems and changes in drug utilization after medication reviews in nursing homes in Oslo, Norway.

Science.gov (United States)

Fog, Amura Francesca; Kvalvaag, Gunnar; Engedal, Knut; Straand, Jørund

2017-12-01

We describe the drug-related problems (DRPs) identified during medication reviews (MRs) and the changes in drug utilization after MRs at nursing homes in Oslo, Norway. We explored predictors for the observed changes. Observational before-after study. Forty-one nursing homes. MRs performed by multidisciplinary teams during November 2011 to February 2014. In all, 2465 long-term care patients. DRPs identified by explicit criteria (STOPP/START and NORGEP) and drug-drug interaction database; interventions to resolve DRPs; drug use changes after MR. A total of 6158 DRPs were identified, an average of 2.6 DRPs/patient, 2.0 for regular and 0.6 for pro re nata (prn) drugs. Of these patients, 17.3% had no DRPs. The remaining 82.7% of the patients had on average 3.0 DRPs/patient. Use of unnecessary drugs (43.5%), excess dosing (12.5%) and lack of monitoring of the drug use (11%) were the most frequent DRPs. Opioids and psychotropic drugs were involved in 34.4% of all DRPs. The mean number of drugs decreased after the MR from 6.8 to 6.3 for regular drugs and from 3.0 to 2.6 for prn drugs. Patients with DRPs experienced a decrease of 1.1 drugs after MR (0.5 for regular and 0.6 for prn drugs). The reduction was most pronounced for the regular use of antipsychotics, antidepressants, hypnotics/sedatives, diuretics, antithrombotic agents, antacid drugs; and for prn use of anxiolytics, opioids, hypnotics/sedatives, metoclopramide and NSAIDs. The medication review resulted in less drug use, especially opioids and psychotropic drugs.

Modeling of the lithium based neutralizer for ITER neutral beam injector

Energy Technology Data Exchange (ETDEWEB)

Dure, F., E-mail: franck.dure@u-psud.fr [LPGP, Laboratoire de Physique des Gaz et Plasmas, CNRS-Universite Paris Sud, Orsay (France); Lifschitz, A.; Bretagne, J.; Maynard, G. [LPGP, Laboratoire de Physique des Gaz et Plasmas, CNRS-Universite Paris Sud, Orsay (France); Simonin, A. [IRFM, Institut de Recherche sur la Fusion Magnetique, CEA Cadarache, 13108 Saint-Paul lez Durance (France); Minea, T. [LPGP, Laboratoire de Physique des Gaz et Plasmas, CNRS-Universite Paris Sud, Orsay (France)

2012-04-04

Highlights: Black-Right-Pointing-Pointer We compare different lithium based neutraliser configurations to the deuterium one. Black-Right-Pointing-Pointer We study characteristics of the secondary plasma and the propagation of the 1 MeV beam. Black-Right-Pointing-Pointer Using lithium increases the neutralisation effiency keeping correct beam focusing. Black-Right-Pointing-Pointer Using lithium also reduces the backstreaming effect in direction of the ion source. - Abstract: To achieve thermonuclear temperatures necessary to produce fusion reactions in the ITER Tokamak, additional heating systems are required. One of the main method to heat the plasma ions in ITER will be the injection of energetic neutrals (NBI). In the neutral beam injector, negative ions (D{sup -}) are electrostatically accelerated to 1 MeV, and then stripped of their extra electron via collisions with a target gas, in a structure known as neutralizer. In the current ITER specification, the target gas is deuterium. It has been recently proposed to use lithium vapor instead of deuterium as target gas in the neutralizer. This would allow to reduce the gas load in the NBI vessel and to improve the neutralization efficiency. A Particle-in-Cell Monte Carlo code has been developed to study the transport of the beams and the plasma formation in the neutralizer. A comparison between Li and D{sub 2} based neutralizers made with this code is presented here, as well as a parametric study on the geometry of the Li based neutralizer. Results demonstrate the feasibility of a Li based neutralizer, and its advantages with respect to the deuterium based one.

Auction based spectrum management of cognitive radio networks

DEFF Research Database (Denmark)

Chang, H. B.; Chen, K.-C.; Prasad, Ramjee

2009-01-01

(PS-MSs), and we therefore construct a cognitive radio network (CRN) consisting of a PRN with multiple CR-MSs. We propose a spectrum management policy framework such that CR-MSs can compete in utilization of the PRN spectrum bands available to opportunistic transmission of CR-MSs by Vickrey auction...... to the PRN, the overall spectrum utilization, the profit of the service provider, the spectrum access opportunity of the CR-MSs are increased to achieve cowin situation for every party in cognitive radio networks.......Cognitive radio (CR) technology is considered as an effective solution to enhance overall spectrum efficiency, especially primary radio network (PRN) typically having relatively low spectrum utilization. However, to realize CR concept, it is essential to provide enough incentives to PRN and extra...

Track reconstruction in discrete detectors by neutral networks

Energy Technology Data Exchange (ETDEWEB)

Glazov, A A; Kisel` , I V; Konotopskaya, E V; Neskoromnyj, V N; Ososkov, G A

1993-12-31

On the basis of applying neutral networks to the track recognition problem the investigations are made according to the specific properties of such discrete detectors as multiwire proportional chambers. These investigations result in the modification of the so-called rotor model in a neutral neural network. The energy function of a network in this modification contains only one cost term. This speeds up calculations considerably. The reduction of the energy function is done by the neuron selection with the help of simplegeometrical and energetical criteria. Besides, the cellular automata were applied to preliminary selection of data that made it possible to create an initial network configuration with the energy closer to its global minimum. The algorithm was tested on 10{sup 4} real three-prong events obtained from the ARES-spectrometer. The results are satisfactory including the noise robustness and good resolution of nearby going tracks. 12 refs.; 10 figs.

Track reconstruction in discrete detectors by neutral networks

International Nuclear Information System (INIS)

Glazov, A.A.; Kisel', I.V.; Konotopskaya, E.V.; Neskoromnyj, V.N.; Ososkov, G.A.

1992-01-01

On the basis of applying neutral networks to the track recognition problem the investigations are made according to the specific properties of such discrete detectors as multiwire proportional chambers. These investigations result in the modification of the so-called rotor model in a neutral neural network. The energy function of a network in this modification contains only one cost term. This speeds up calculations considerably. The reduction of the energy function is done by the neuron selection with the help of simplegeometrical and energetical criteria. Besides, the cellular automata were applied to preliminary selection of data that made it possible to create an initial network configuration with the energy closer to its global minimum. The algorithm was tested on 10 4 real three-prong events obtained from the ARES-spectrometer. The results are satisfactory including the noise robustness and good resolution of nearby going tracks. 12 refs.; 10 figs

Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults.

Science.gov (United States)

Miyaji, Karina Takesaki; Avelino-Silva, Vivian Iida; Simões, Marisol; Freire, Marcos da Silva; Medeiros, Carlos Roberto de; Braga, Patrícia Emilia; Neves, Maria Angélica Acalá; Lopes, Marta Heloisa; Kallas, Esper Georges; Sartori, Ana Marli Christovam

2017-04-03

The World Health Organization (WHO) recommends one single dose of the Yellow Fever (YF) vaccine based on studies of antibody persistency in healthy adults. We assessed the prevalence and titers of YF virus neutralizing antibodies in previously vaccinated persons aged  60 years, in comparison to younger adults. We also evaluated the correlation between antibody titers and the time since vaccination among participants who received one vaccine dose, and the seropositivity among participants vaccinated prior to or within the past 10 years. previously vaccinated healthy persons aged  18 years were included. YF virus neutralizing antibody titers were determined by means of the 50% Plaque Reduction Neutralization Test. 46 persons aged  60 years and 48 persons aged 18 to 59 years were enrolled. There was no significant difference in the prevalence of YF virus neutralizing antibodies between the two groups (p = 0.263). However, titers were significantly lower in the elderly (p = 0.022). There was no correlation between YF virus neutralizing antibody titers and the time since vaccination. There was no significant difference in seropositivity among participants vaccinated prior to or within the past 10 years. the clinical relevance of the observed difference in YF virus neutralizing antibody titers between the two groups is not clear.

Study of neutral particles

International Nuclear Information System (INIS)

Bartel, W.; Bulos, F.; Eisner, A.

1975-01-01

The range of physics problems for which a detector emphasizing neutrals is most suitable is discussed. The primary goals are the all neutrals cross section, sigma/sub o/ (e + e - → neutrals), the characterization of the neutral energy in multi-hadronic events, the search for monoenergetic photons, and good sensitivity in the difficult region of low energy photons. Those features of multi-hadronic events which are most relevant to a neutral detector were calculated using a jet model with parameters extrapolated from SPEAR energies. These distributions are presented and discussed

Toxic emissions and devaluated CO2-neutrality

DEFF Research Database (Denmark)

Czeskleba-Dupont, Rolf

Environmental, energy and climate policies need fresh reflections. In order to evaluate toxics reduction policies the Stockholm Convention on Persistent Organic Pollutants is mandatory. Denmark's function as lead country for dioxin research in the context of the OSPAR Convention is contrasted...... with a climate policy whose goals of CO2-reduction were made operational by green-wash. Arguments are given for the devaluation of CO2- neutrality in case of burning wood. Alternative practices as storing C in high quality wood products and/or leaving wood in the forest are recommended. A counter......-productive effect of dioxin formation in the cooling phase of wood burning appliances has been registered akin to de-novo-synthesis in municipal solid waste incinerators. Researchers, regulators and the public are, however, still preoccupied by notions of oven design and operation parameters, assuming that dioxin...

Comparison of the Hemagglutination Inhibition Test and IgG ELISA in Categorizing Primary and Secondary Dengue Infections Based on the Plaque Reduction Neutralization Test

Directory of Open Access Journals (Sweden)

Nurhayati Lukman

2016-01-01

Full Text Available Secondary dengue infection by heterotypic serotypes is associated with severe manifestations of disease, that is, dengue hemorrhagic fever (DHF and dengue shock syndrome (DSS. The World Health Organization (WHO has recommended criteria based on the hemagglutination inhibition (HI test to distinguish between primary and secondary dengue infections. Since the HI test has practical limitations and disadvantages, we evaluated the accuracy of WHO HI criteria and compared it with criteria based on an IgG enzyme-linked immunosorbent assay (ELISA using a plaque reduction neutralization test (PRNT as the gold standard. Both WHO HI criteria and IgG ELISA criteria performed strongly (16/16 in determining primary infection. However, to determine secondary infection, the IgG ELISA criteria performed better (72/73 compared to the WHO HI criteria (23/73.

Dose reduction in spiral CT angiography of thoracic outlet syndrome by anatomically adapted tube current modulation

International Nuclear Information System (INIS)

Mastora, I.; Remy-Jardin, M.; Remy, J.; Suess, C.; Scherf, C.; Guillot, J.P.

2001-01-01

The aim of this study was to evaluate dose reduction in spiral CT angiography of the thoracic outlet by on-line tube-current control. Prospectively, 114 patients undergoing spiral CT angiography of the subclavian artery for thoracic outlet arterial syndromes were evaluated with and without tube-current modulation at the same session (scanning parameters for the two successive angiograms, one in the neutral position and one after the postural maneuver): 140 kV; 206 mA; scan time 0.75 s; collimation 3 mm; pitch = (1). The dose reduction system was applied in the neutral position in the first 92 consecutive patients and after postural maneuver in the remaining 22 consecutive patients. Dose reduction and image quality were analyzed in the overall study group (group 1; n = 114). The influence of the arm position was assessed in 44 of the 114 patients (group 2), matched by the transverse diameter of the upper thorax. The mean dose reduction was 33 % in group 1 (range 22-40 %) and 34 % in group 2 (range 26-40 %). In group 2 the only difference in image quality was a significantly higher frequency of graininess on low-dose scans compared with reference scans whatever the patient's arm position, graded as minimal in 38 of the 44 patients (86 %). When the low-dose technique was applied after postural maneuver in group 2: (a) the mean dose reduction was significantly higher (35 vs 32 % in the neutral position; p = 0.006); (b) graininess was less frequent (82 vs 91 % in the neutral position); and (c) the percentage of graininess graded as minimal was significantly higher (83 vs 70 % in the neutral position; p = 0.2027). On-line tube-current modulation enables dose reduction on high-quality, diagnostic spiral CT angiograms of the thoracic outlet and should be applied during data acquisition in the neutral position and after postural maneuver for optimal use. (orig.)

Dose reduction in spiral CT angiography of thoracic outlet syndrome by anatomically adapted tube current modulation

Energy Technology Data Exchange (ETDEWEB)

Mastora, I.; Remy-Jardin, M.; Remy, J. [Dept. of Radiology, University Center Hospital Calmette, Lille (France); Medical Research Group, Lille (France); Suess, C.; Scherf, C. [Siemens Medical Systems, Forcheim (Germany); Guillot, J.P. [Dept. of Radiology, University Center Hospital Calmette, Lille (France)

2001-04-01

The aim of this study was to evaluate dose reduction in spiral CT angiography of the thoracic outlet by on-line tube-current control. Prospectively, 114 patients undergoing spiral CT angiography of the subclavian artery for thoracic outlet arterial syndromes were evaluated with and without tube-current modulation at the same session (scanning parameters for the two successive angiograms, one in the neutral position and one after the postural maneuver): 140 kV; 206 mA; scan time 0.75 s; collimation 3 mm; pitch = (1). The dose reduction system was applied in the neutral position in the first 92 consecutive patients and after postural maneuver in the remaining 22 consecutive patients. Dose reduction and image quality were analyzed in the overall study group (group 1; n = 114). The influence of the arm position was assessed in 44 of the 114 patients (group 2), matched by the transverse diameter of the upper thorax. The mean dose reduction was 33 % in group 1 (range 22-40 %) and 34 % in group 2 (range 26-40 %). In group 2 the only difference in image quality was a significantly higher frequency of graininess on low-dose scans compared with reference scans whatever the patient's arm position, graded as minimal in 38 of the 44 patients (86 %). When the low-dose technique was applied after postural maneuver in group 2: (a) the mean dose reduction was significantly higher (35 vs 32 % in the neutral position; p = 0.006); (b) graininess was less frequent (82 vs 91 % in the neutral position); and (c) the percentage of graininess graded as minimal was significantly higher (83 vs 70 % in the neutral position; p = 0.2027). On-line tube-current modulation enables dose reduction on high-quality, diagnostic spiral CT angiograms of the thoracic outlet and should be applied during data acquisition in the neutral position and after postural maneuver for optimal use. (orig.)

Neutral beam monitoring

International Nuclear Information System (INIS)

Fink, J.H.

1979-01-01

A neutral beam generated by passing accelerated ions through a walled cell containing a low energy neutral gas, such that charge exchange partially neutralizes the high energy beam, is monitored by detecting the current flowing through the cell wall produced by low energy ions which drift to the wall after the charge exchange. By segmenting the wall into radial and longitudinal segments various beam conditions are identified. (U.K.)

Bunched beam neutralization

International Nuclear Information System (INIS)

Gammel, G.M.; Maschke, A.W.; Mobley, R.M.

1979-01-01

One of the steps involved in producing an intense ion beam from conventional accelerators for Heavy Ion Fusion (HIF) is beam bunching. To maintain space charge neutralized transport, neutralization must occur more quickly as the beam bunches. It has been demonstrated at BNL that a 60 mA proton beam from a 750 kV Cockcroft--Walton can be neutralized within a microsecond. The special problem in HIF is that the neutralization must occur in a time scale of nanoseconds. To study neutralization on a faster time scale, a 40 mA, 450 kV proton beam was bunched at 16 MHz. A biased Faraday cup sampled the bunched beam at the position where maximum bunching was nominally expected, about 2.5 meters from the buncher. Part of the drift region, about 1.8 meters, was occupied by a series of Gabor lenses. In addition to enhancing beam transport by transverse focussing, the background cloud of electrons in the lenses provided an extra degree of neutralization. With no lens, the best bunch factor was at least 20. Bunch factor is defined here as the ratio of the distance between bunches to the FWHM bunch length. With the lens, it was hoped that the increased plasma frequency would decrease the neutralization time and cause an increase in the bunch factor. In fact, with the lens, the instantaneous current increased about three times, but the bunch factor dropped to about 10. Even with the lens, the FWHM of the bunches at the position of maximum bunching was still comparable to or less than the oscillation period of the surrounding electron plasma. Thus, the electron density in the lens must increase before neutralization could be effective in this case, or bunching should be done at a lower frequency

Quantum-chemical studies on the favored and rare tautomers of neutral and redox adenine.

Science.gov (United States)

Raczyńska, Ewa D; Makowski, Mariusz; Zientara-Rytter, Katarzyna; Kolczyńska, Katarzyna; Stępniewski, Tomasz M; Hallmann, Małgorzata

2013-02-21

All possible twenty-three prototropic tautomers of neutral and redox adenine (nine amine and fourteen imine forms, including geometric isomerism of the exo ═NH group) were examined in vacuo {DFT(B3LYP)/6-311+G(d,p)}. The NH → NH conversions as well as those usually omitted, NH → CH and CH → CH, were considered. An interesting change of the tautomeric preference occurs when proceeding from neutral to reduced adenine. One-electron reduction favors the nonaromatic amine C8H-N10H tautomer. This tautomeric preference is similar to that (C2H) for reduced imidazole. Water molecules (PCM model) seem to not change this trend. They influence solely the relative energies. The DFT vertical detachment energy in the gas phase is positive for each tautomer, e.g., 0.03 eV for N9H-N10H and 1.84 eV for C8H-N10H. The DFT adiabatic electron affinity for the favored process, neutral N9H-N10H → reduced C8H-N10H (ground states), is equal to 0.18 eV at 0 K (ZPE included). One-electron oxidation does not change the tautomeric preference in the gas phase. The aromatic amine N9H-N10H tautomer is favored for the oxidized molecule similarly as for the neutral one. The DFT adiabatic ionization potential for the favored process, neutral N9H-N10H → oxidized N9H-N10H (ground states), is equal to 8.12 eV at 0 K (ZPE included). Water molecules (PCM model) seem to influence solely the composition of the tautomeric mixture and the relative energies. They change the energies of the oxidation and reduction processes by ca. 2 eV.

Neutralized transport experiment

International Nuclear Information System (INIS)

Roy, P.K.; Yu, S.S.; Eylon, S.; Henestroza, E.; Anders, A.; Gilson, E.P.; Bieniosek, F.M.; Greenway, W.G.; Logan, B.G.; Waldron, W.L.; Shuman, D.B.; Vanecek, D.L.; Welch, D.R.; Rose, D.V.; Thoma, C.; Davidson, R.C.; Efthimion, P.C.; Kaganovich, I.; Sefkow, A.B.; Sharp, W.M.

2005-01-01

Experimental details on providing active neutralization of high brightness ion beam have been demonstrated for Heavy Ion Fusion program. A K + beam was extracted from a variable-perveance injector and transported through 2.4 m long quadrupole lattice for final focusing. Neutralization was provided by a localized cathode arc plasma plug and a RF volume plasma system. Effects of beam perveance, emittance, convergence focusing angle, and axial focusing position on neutralization have been investigated. Good agreement has been observed with theory and experiment throughout the study

A neutral sampling formula for multiple samples and an `exact' test of neutrality

NARCIS (Netherlands)

Etienne, R.S.

2007-01-01

As the utility of the neutral theory of biodiversity is increasingly being recognized, there is also an increasing need for proper tools to evaluate the relative importance of neutral processes (dispersal limitation and stochasticity). One of the key features of neutral theory is its close link to

A neutral sampling formula for multiple samples and an 'exact' test of neutrality

NARCIS (Netherlands)

Etienne, Rampal S.

As the utility of the neutral theory of biodiversity is increasingly being recognized, there is also an increasing need for proper tools to evaluate the relative importance of neutral processes (dispersal limitation and stochasticity). One of the key features of neutral theory is its close link to

Search for neutral leptons

International Nuclear Information System (INIS)

Perl, M.L.

1984-12-01

At present we know of three kinds of neutral leptons: the electron neutrino, the muon neutrino, and the tau neutrino. This paper reviews the search for additional neutral leptons. The method and significance of a search depends upon the model used for the neutral lepton being sought. Some models for the properties and decay modes of proposed neutral leptons are described. Past and present searches are reviewed. The limits obtained by some completed searches are given, and the methods of searches in progress are described. Future searches are discussed. 41 references

Neutral currents

International Nuclear Information System (INIS)

Paschos, E.A.

1977-01-01

It is stated that over the past few years considerable progress has been made in the field of weak interactions. The existence of neutral currents involving leptons and hadrons has been established and some of the questions concerning their detailed structure have been answered. This imposes constraints on the gauge theories and has eliminated large classes of models. New questions have also been raised, one of which concerns the conservation laws obeyed by neutral currents. The wide range of investigations is impressive and is expected to continue with new results from particle, nuclear, and atomic physics. Headings include - various aspects of a gauge theory (choice of group, the symmetry breaking scheme, representation assignments for fermion fields); space-time structure; isospin structure; leptonic neutral currents; and atomic experiments. (U.K.)

The importance of Bordetella pertussis strains which do not produce virulence factors in the epidemiology of pertussis

Directory of Open Access Journals (Sweden)

Maciej Polak

2017-05-01

Full Text Available Bordetella pertussis strains, which have lost the ability to produce antigens, such as pertactin - Prn, pertussis toxin - Ptx, filamentous haemagglutinin - FHA, fimbriae type 2 and 3 - Fim 2 and 3, tracheal colonization factor - TcfA, have recently been isolated in countries with a high vaccination coverage. The emergence of such isolates might have resulted from B. pertussis natural evolution course or adaptive mechanisms, allowing increased circulation of the pathogen in vaccinated populations. So far, the majority of described mutants were deficient in the Prn production. Prn deficient isolates were found in countries which use acellular pertussis vaccines (aP in routine immunization programmes. The increase of frequency of Prn¯ strains isolation was correlated with the period of routine vaccination with aP vaccines. In most countries, the spread of these isolates has resulted from independent mutations rather than from the expansion of a single clone. Prn¯ isolates were collected from patients showing typical clinical symptoms of pertussis found for Prn+ strains. Results of in vitro and in vivo studies have shown that Prn¯, Ptx¯ and FHA¯ isolates retain cytotoxic properties, and besides Ptx¯ isolates, were lethal in intranasally infected mice. Further explanation of the impact of antigen deficiencies on virulence and transmission of B. pertussis in the context of the continuous increase of pertussis incidence is necessary to develop a new, optimized strategy of pertussis prevention.

Covalent modification of multiwalled carbon nanotubes with neutral red for the fabrication of an amperometric hydrogen peroxide sensor

International Nuclear Information System (INIS)

Jeykumari, D R Shobha; Narayanan, S Sriman

2007-01-01

The nanoscale dimensions, graphitic surface chemistry and electronic properties of multiwalled carbon nanotubes (MWNTs) make them an ideal candidate for chemical and biochemical sensing. In this paper we explore a covalent chemical strategy for functionalization of MWNTs with neutral red through carbodiimide coupling between the primary amine of neutral red and carboxyl groups of the carbon nanotubes. The construction of an amperometric sensor was achieved by abrasive immobilization of the functionalized MWNTs on a paraffin impregnated graphite electrode followed by a coating of a thin film of nafion. The neutral red functionalized MWNTs were characterized by spectroscopic and electroanalytical methods. From the voltammetric studies, MWNTs were found to exhibit a higher accessible surface area in electrochemical reactions. The modified electrode exhibited stable electrocatalytic activity toward hydrogen peroxide reduction in a wide potential range. A significant decrease in overvoltage for the reduction of hydrogen peroxide, as well as a dramatic increase in the peak currents in comparison with a bare graphite electrode were observed. Such an ability of neutral red functionalized carbon nanotubes to promote the hydrogen peroxide electron transfer reaction with a short response time (<4 s) and long-term stability, a low detection limit, an extended linear concentration range and a high sensitivity suggest great promise for dehydrogenase and oxidase based amperometric biosensors

Covalent modification of multiwalled carbon nanotubes with neutral red for the fabrication of an amperometric hydrogen peroxide sensor

Energy Technology Data Exchange (ETDEWEB)

Jeykumari, D R Shobha; Narayanan, S Sriman [Department of Analytical Chemistry, School of Chemical Sciences, University of Madras, Guindy Campus, Chennai-600 025 (India)

2007-03-28

The nanoscale dimensions, graphitic surface chemistry and electronic properties of multiwalled carbon nanotubes (MWNTs) make them an ideal candidate for chemical and biochemical sensing. In this paper we explore a covalent chemical strategy for functionalization of MWNTs with neutral red through carbodiimide coupling between the primary amine of neutral red and carboxyl groups of the carbon nanotubes. The construction of an amperometric sensor was achieved by abrasive immobilization of the functionalized MWNTs on a paraffin impregnated graphite electrode followed by a coating of a thin film of nafion. The neutral red functionalized MWNTs were characterized by spectroscopic and electroanalytical methods. From the voltammetric studies, MWNTs were found to exhibit a higher accessible surface area in electrochemical reactions. The modified electrode exhibited stable electrocatalytic activity toward hydrogen peroxide reduction in a wide potential range. A significant decrease in overvoltage for the reduction of hydrogen peroxide, as well as a dramatic increase in the peak currents in comparison with a bare graphite electrode were observed. Such an ability of neutral red functionalized carbon nanotubes to promote the hydrogen peroxide electron transfer reaction with a short response time (<4 s) and long-term stability, a low detection limit, an extended linear concentration range and a high sensitivity suggest great promise for dehydrogenase and oxidase based amperometric biosensors.

Plasma neutralizer for H- beams

International Nuclear Information System (INIS)

Grossman, M.W.

1977-01-01

Neutralization of H - beams by a hydrogen plasma is discussed. Optimum target thickness and maximum neutralization efficiency as a function of the fraction of the hydrogen target gas ionized is calculated for different H - beam energies. Also, the variation of neutralization efficiency with respect to target thickness for different H - beam energies is computed. The dispersion of the neutralized beam by a magnetic field for different energies and different values of B . z is found. Finally, a type of plasma jet is proposed, which may be suitable for a compact H - neutralizer

Changes in EEG spectral power on perception of neutral and emotional words in patients with schizophrenia, their relatives, and healthy subjects from the general population.

Science.gov (United States)

Alfimova, M V; Uvarova, L G

2008-06-01

EEG correlates of impairments in the processing of emotiogenic information which might reflect a genetic predisposition to schizophrenia were sought by studying the dynamics of EEG rhythm powers on presentation of neutral and emotional words in 36 patients with schizophrenia, 50 of their unaffected first-degree relatives, and 47 healthy subjects without any inherited predisposition to psychoses. In controls, passive hearing of neutral words produced minimal changes in cortical rhythms, predominantly in the form of increases in the power levels of slow and fast waves, while perception of emotional words was accompanied by generalized reductions in the power of the alpha and beta(1) rhythms and regionally specific suppression of theta and beta(2) activity. Patients and their relatives demonstrated reductions in power of alpha and beta(1) activity, with an increase in delta power on hearing both groups of words. Thus, differences in responses to neutral and emotional words in patients and their relatives were weaker, because of increased reactions to neutral words. These results may identify EEG reflections of pathology of involuntary attention, which is familial and, evidently, inherited in nature. No reduction in reactions to emotiogenic stimuli was seen in patients' families.

Neutralization escape mutants define a dominant immunogenic neutralization site on hepatitis A virus

International Nuclear Information System (INIS)

Stapleton, J.T.; Lemon, S.M.

1987-01-01

Hepatitis A virus is an hepatotrophic human picornavirus which demonstrates little antigenic variability. To topologically map immunogenic sites on hepatitis A virus which elicit neutralizing antibodies, eight neutralizing monoclonal antibodies were evaluated in competition immunoassays employing radiolabeled monoclonal antibodies and HM-175 virus. Whereas two antibodies (K3-4C8 and K3-2F2) bound to intimately overlapping epitopes, the epitope bound by a third antibody (B5-B3) was distinctly different as evidenced by a lack of competition between antibodies for binding to the virus. The other five antibodies variably blocked the binding of both K3-4C8-K3-2F2 and B5-B3, suggesting that these epitopes are closely spaced and perhaps part of a single neutralization immunogenic site. Several combinations of monoclonal antibodies blocked the binding of polyclonal human convalescent antibody by greater than 96%, indicating that the neutralization epitopes bound by these antibodies are immunodominant in humans. Spontaneously arising HM-175 mutants were selected for resistance to monoclonal antibody-mediated neutralization. Neutralization resistance was associated with reduced antibody binding. These results suggest that hepatitis A virus may differ from poliovirus in possessing a single, dominant neutralization immunogenic site and therefore may be a better candidate for synthetic peptide or antiidiotype vaccine development

On neutral plasma oscillations

International Nuclear Information System (INIS)

Shadwick, B.A.; Morrison, P.J.

1993-06-01

We examine the conditions for the existence of spectrally stable neutral modes in a Vlasov-Poisson plasma and show that for stable equilibria of systems that have unbounded spatial domain, the only possible neutral modes are those with phase velocities that correspond to stationary inflection points of the equilibrium distribution function. It is seen that these neutral modes can possess positive or negative free energy

On neutral plasma oscillations

International Nuclear Information System (INIS)

Shadwick, B.A.; Texas Univ., Austin; Morrison, P.J.; Texas Univ., Austin

1994-01-01

We examine the conditions for the existence of spectrally stable neutral modes in a Vlasov-Poisson plasma and show that for stable equilibria of systems that have unbounded spatial domain, the only possible neutral modes are those with phase velocities that correspond to stationary inflection points of the equilibrium distribution function. It is seen that these neutral modes can posses positive or negative free energy. (orig.)

Automated Facial Coding Software Outperforms People in Recognizing Neutral Faces as Neutral from Standardized Datasets

Directory of Open Access Journals (Sweden)

Peter eLewinski

2015-09-01

Full Text Available Little is known about people’s accuracy of recognizing neutral faces as neutral. In this paper, I demonstrate the importance of knowing how well people recognize neutral faces. I contrasted human recognition scores of 100 typical, neutral front-up facial images with scores of an arguably objective judge – automated facial coding (AFC software. I hypothesized that the software would outperform humans in recognizing neutral faces because of the inherently objective nature of computer algorithms. Results confirmed this hypothesis. I provided the first-ever evidence that computer software (90% was more accurate in recognizing neutral faces than people were (59%. I posited two theoretical mechanisms, i.e. smile-as-a-baseline and false recognition of emotion, as possible explanations for my findings.

First observations of partially neutralized and quasineutral plasmas in the Columbia Non-neutral Torus

Science.gov (United States)

Sarasola, Xabier; Brenner, Paul; Hahn, Michael; Pedersen, Thomas

2009-11-01

The Columbia Non-neutral Torus (CNT) is the first stellarator devoted to the study of pure electron, partially neutralized and positron-electron plasmas. To date, CNT usually operates with electron rich plasmas (with negligible ion density) [1], but a stellarator can also confine plasmas of arbitrary degree of neutralization. In CNT the accumulation of ions alters the equilibrium of electron plasmas and a global instability has been observed when the ion fraction exceeds 10 %. A characterization of this instability is presented in [2], analyzing its parameter dependence and spatial structure (non- resonant with rational surfaces). A new set of experiments is currently underway studying plasmas of arbitrary degree of neutralization, ranging from pure electron to quasineutral plasmas. Basic observations show that the plasma potential decouples from emitter bias when we increase the degree of the neutralization of our plasmas. Partially neutralized plasmas are also characterized by multiple mode behavior with dominant modes between 20 and 200 kHz. When the plasma becomes quasineutral, it reverts to single mode behavior. The first results on partially neutralized plasmas confined on magnetic surfaces will be presented. [1] J. Kremer, PRL 97, (2006) 095003 [2] Q. Marksteiner, PRL 100 (2008) 065002

Plasma/Neutral-Beam Etching Apparatus

Science.gov (United States)

Langer, William; Cohen, Samuel; Cuthbertson, John; Manos, Dennis; Motley, Robert

1989-01-01

Energies of neutral particles controllable. Apparatus developed to produce intense beams of reactant atoms for simulating low-Earth-orbit oxygen erosion, for studying beam-gas collisions, and for etching semiconductor substrates. Neutral beam formed by neutralization and reflection of accelerated plasma on metal plate. Plasma ejected from coaxial plasma gun toward neutralizing plate, where turned into beam of atoms or molecules and aimed at substrate to be etched.

Neutral theory and the species abundance distribution: recent developments and prospects for unifying niche and neutral perspectives

Science.gov (United States)

Matthews, Thomas J; Whittaker, Robert J

2014-01-01

Published in 2001, The Unified Neutral Theory of Biodiversity and Biogeography (UNTB) emphasizes the importance of stochastic processes in ecological community structure, and has challenged the traditional niche-based view of ecology. While neutral models have since been applied to a broad range of ecological and macroecological phenomena, the majority of research relating to neutral theory has focused exclusively on the species abundance distribution (SAD). Here, we synthesize the large body of work on neutral theory in the context of the species abundance distribution, with a particular focus on integrating ideas from neutral theory with traditional niche theory. First, we summarize the basic tenets of neutral theory; both in general and in the context of SADs. Second, we explore the issues associated with neutral theory and the SAD, such as complications with fitting and model comparison, the underlying assumptions of neutral models, and the difficultly of linking pattern to process. Third, we highlight the advances in understanding of SADs that have resulted from neutral theory and models. Finally, we focus consideration on recent developments aimed at unifying neutral- and niche-based approaches to ecology, with a particular emphasis on what this means for SAD theory, embracing, for instance, ideas of emergent neutrality and stochastic niche theory. We put forward the argument that the prospect of the unification of niche and neutral perspectives represents one of the most promising future avenues of neutral theory research. PMID:25360266

Neutral theory and the species abundance distribution: recent developments and prospects for unifying niche and neutral perspectives.

Science.gov (United States)

Matthews, Thomas J; Whittaker, Robert J

2014-06-01

Published in 2001, The Unified Neutral Theory of Biodiversity and Biogeography (UNTB) emphasizes the importance of stochastic processes in ecological community structure, and has challenged the traditional niche-based view of ecology. While neutral models have since been applied to a broad range of ecological and macroecological phenomena, the majority of research relating to neutral theory has focused exclusively on the species abundance distribution (SAD). Here, we synthesize the large body of work on neutral theory in the context of the species abundance distribution, with a particular focus on integrating ideas from neutral theory with traditional niche theory. First, we summarize the basic tenets of neutral theory; both in general and in the context of SADs. Second, we explore the issues associated with neutral theory and the SAD, such as complications with fitting and model comparison, the underlying assumptions of neutral models, and the difficultly of linking pattern to process. Third, we highlight the advances in understanding of SADs that have resulted from neutral theory and models. Finally, we focus consideration on recent developments aimed at unifying neutral- and niche-based approaches to ecology, with a particular emphasis on what this means for SAD theory, embracing, for instance, ideas of emergent neutrality and stochastic niche theory. We put forward the argument that the prospect of the unification of niche and neutral perspectives represents one of the most promising future avenues of neutral theory research.

On plasma-neutral gas interaction

International Nuclear Information System (INIS)

Venkataramani, N.; Mattoo, S.K.

1980-01-01

The importance of plasma-neutral gas interaction layer has been emphasized by pointing out its application to a wide variety of physical phenomena. The interaction of a magnetised plasma stream penetrating a neutral gas cloud is discussed in the light of Alfven's critical velocity and Varma's threshold velocity on the ionising interaction. Interaction of a moving magnetised plasma with a stationary neutral gas has been studied and described. The device comprises of a plasma gun and an interaction region where neutral gas cloud is injected. The interaction region is provided with a transverse magnetic field of upto 1000 G. Several diagnostics deployed at the interaction region to make measurements on the macroscopic parameters of plasma and neutral gas are described. The parameters of discharge circuits are measured with high current and voltage probes. An interaction between a magnetised plasma stream and a neutral gas cloud is demonstrated. It is shown that this interaction does not have Varma's threshold on their relative velocity. The Alfven's critical velocity phenomenon is shown to depend on the integrated column neutral gas density that a plasma stream encounters while penetrating through it and not on the neutral gas density in the range of 10 17 -10 21 m -3 . (auth.)

Is an inequality-neutral flat tax reform really neutral?

OpenAIRE

Juan Prieto Rodríguez; Juan Gabriel Rodríguez; Rafael Salas

2004-01-01

. Let us assume a revenue- and inequality-neutral flat tax reform shifting from a graduated-rate tax. Is this reform really neutral in terms of the income distribution? Traditionally, there has been a bias toward the inequality analysis, forgetting other relevant aspects of the income distribution. This kind of reforms implies a set of composite transfers, both progressive and regressive, even though inequality remains unchanged. This paper shows that polarization is a useful tool for charact...

The neutralization of acidic coal mine lakes by additions of natural organic matter: a mesocosm test

International Nuclear Information System (INIS)

Brugam, R.B.; Gastineau, J.; Ratcliff, E.

1995-01-01

Cylindrical polyethylene enclosures 3 m in length and 1 m in diameter reaching from the surface to the bottom were constructed in an acid (pH=3.1) lake on a coal surface mine in southern Illinois. Wheat straw was added to the enclosures to test the effects of dissimilatory sulfate reduction on water chemistry. Added straw increased sulfide concentrations, raised pH to 6.5, reduced O 2 and increased acid neutralizing capacity of the enclosed water columns when compared with a control enclosure and with the open lake. Generation of acid neutralizing capacity exceeded the standing stock of sulfide indicating that sulfide was removed either by precipitation of FeS or outgassing of H 2 S. The pH and acid neutralizing capacity within the enclosures eventually returned to the level of the surrounding lake because of water exchange around the enclosure walls. Our results show that additions of organic matter to acid surface mine lakes result in the generation of acid neutralizing capacity

The effects of dissociation on information processing for analogue trauma and neutral stimuli: a laboratory study.

Science.gov (United States)

Olsen, Shira A; Beck, J Gayle

2012-01-01

This study investigated the effects of high and low levels of dissociation on information processing for analogue trauma and neutral stimuli. Fifty-four undergraduate females who reported high and low levels of trait dissociation were presented with two films, one depicting traumatic events, the other containing neutral material. Participants completed a divided attention task (yielding a proxy measure of attention), as well as explicit memory (free-recall) and implicit memory (word-stem completion) tasks for both films. Results indicated that the high DES group showed less attention and had poorer recall for the analogue trauma stimuli, relative to the neutral stimuli and the low DES group. These findings suggest that high levels of trait dissociation are associated with reductions in attention and memory for analogue trauma stimuli, relative to neutral stimuli and relative to low trait dissociation. Implications for the role of cognitive factors in the etiology of negative post-trauma responses are discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

Neutral Buoyancy Laboratory (NBL)

Data.gov (United States)

Federal Laboratory Consortium — The Neutral Buoyancy Laboratory (NBL) is an astronaut training facility and neutral buoyancy pool operated by NASA and located at the Sonny Carter Training Facility,...

Effects of large rate coefficients for ion-polar neutral reactions on chemical models of dense interstellar clouds

International Nuclear Information System (INIS)

Herbst, E.; Leung, C.M.; Rensselaer Polytechnic Institute, Troy, NY)

1986-01-01

Pseudo-time-dependent models of the gas phase chemistry of dense interstellar clouds have been run with large rate coefficients for reactions between ions and polar neutral species, as advocated by Adams, Smith, and Clary. The higher rate coefficients normally lead to a reduction in both the peak and steady state abundances of polar neutrals, which can be as large as an order of magnitude but is more often smaller. Other differences between the results of these models and previous results are also discussed. 38 references

A rule-based computer control system for PBX-M neutral beams

International Nuclear Information System (INIS)

Frank, K.T.; Kozub, T.A.; Kugel, H.W.

1987-01-01

The Princeton Beta Experiment (PBX) neutral beams have been routinely operated under automatic computer control. A major upgrade of the computer configuration was undertaken to coincide with the PBX machine modification. The primary tasks included in the computer control system are data acquisition, waveform reduction, automatic control and data storage. The portion of the system which will remain intact is the rule-based approach to automatic control. Increased computational and storage capability will allow the expansion of the knowledge base previously used. The hardware configuration supported by the PBX Neutral Beam (XNB) software includes a dedicated Microvax with five CAMAC crates and four process controllers. The control algorithms are rule-based and goal-driven. The automatic control system raises ion source electrical parameters to selected energy goals and maintains these levels until new goals are requested or faults are detected

Neutral currents

International Nuclear Information System (INIS)

Aubert, B.

1994-11-01

The evidence for the existence of weak neutral current has been a very controverted topics in the early 1970's, as well as the muon did in the 1930's. The history is very rich considering the evolution of the experimental techniques in high energy particle physics. The history of the discovery and the study of weak neutral current is reviewed. Later the quest of the intermediate vector boson continues with the decision of the community to build a large proton antiproton collider. (K.A.). 14 refs., 1 fig

Lifetime of rho meson in correlation with magnetic-dimensional reduction

Energy Technology Data Exchange (ETDEWEB)

Kawaguchi, Mamiya [Nagoya University, Department of Physics, Nagoya (Japan); Matsuzaki, Shinya [Nagoya University, Department of Physics, Nagoya (Japan); Nagoya University, Institute for Advanced Research, Nagoya (Japan)

2017-04-15

It is naively expected that in a strong magnetic configuration, the Landau quantization ceases the neutral rho meson to decay to the charged pion pair, so the neutral rho meson will be long-lived. To closely access this naive observation, we explicitly compute the charged pion loop in the magnetic field at the one-loop level, to evaluate the magnetic dependence of the lifetime for the neutral rho meson as well as its mass. Due to the dimensional reduction induced by the magnetic field (violation of the Lorentz invariance), the polarization (spin s{sub z} = 0, ±1) modes of the rho meson, as well as the corresponding pole mass and width, are decomposed in a nontrivial manner compared to the vacuum case. To see the significance of the reduction effect, we simply take the lowest Landau level approximation to analyze the spin-dependent rho masses and widths. We find that the ''fate'' of the rho meson may be more complicated because of the magnetic-dimensional reduction: as the magnetic field increases, the rho width for the spin s{sub z} = 0 starts to develop, reaches a peak, then vanishes at the critical magnetic field to which the folklore refers. On the other side, the decay rates of the other rhos for s{sub z} = ±1 monotonically increase as the magnetic field develops. The correlation between the polarization dependence and the Landau level truncation is also addressed. (orig.)

Simultaneous temperature measurement of ionospheric plasma and neutral atmosphere with K-10-11 rocket

International Nuclear Information System (INIS)

Murasato, Yukio; Kaneko, Osamu; Sasaki, Susumu; Kawashima, Nobuki; Kibune, Tadashi.

1976-01-01

Ion temperature and neutral atmospheric temperature in lower ionospheric layer were measured by the ''Shadow Method'', which has been developed and improved by the authors. The principle of the method, which utilizes the fact that the shadow due to the reduction of density of medium behind on obstacle depends upon the flow velocity and the temperature of the medium, is briefly explained together with the apparatus used for the measurement. A pair of the Langmuir probes with the interval of 44 mm was used for the measurement of ion temperature. For the measurement of the neutral atmospheric temperature, its density was measured with the ionization gauge. The measuring system was mounted on the K-10-11 rocket, and launched from KSC at 2 p.m., September 24, 1975. Although the rocket itself reached its highest altitude of 196 km, the temperature measurement was performed between the altitude of 80 km and 140 km. The measured temperatures of ions, neutral atmosphere, and electrons are presented as the functions of altitude. It is confirmed that the temperatures of ions and neutral atmosphere are lower than that of electrons in that range of altitude. (Aoki, K.)

Comparative efficacy of tadalafil once daily in men with erectile dysfunction who demonstrated previous partial responses to as-needed sildenafil, tadalafil, or vardenafil.

Science.gov (United States)

Kim, Edward; Seftel, Allen; Goldfischer, Evan; Baygani, Simin; Burns, Patrick

2015-02-01

Phosphodiesterase type-5 inhibitors (PDE5Is) are first-line therapies for erectile dysfunction (ED). Sildenafil (SIL) and vardenafil (VAR) are approved for as-needed (PRN) dosing; tadalafil (TAD) is approved for both PRN and once-a-day (OaD) dosing for ED. Recent evidence suggests that TAD-OaD may be effective as therapy in men with an incomplete response to PRN-PDE5I therapy. This study evaluated whether TAD-OaD provides similar efficacy in men with ED who had previously demonstrated a partial response to PRN-PDE5I therapy. In this randomized, double-blind, placebo-controlled trial, men with a ≥3 month ED history received SIL 100 mg, TAD 20 mg, or VAR 20 mg during a 4 week open-label lead-in period. Those with International Index of Erectile Function - Erectile Function (IIEF-EF) domain scores TAD 2.5 mg up-titrated to 5 mg, TAD 5 mg, or placebo (PBO) OaD for 12 weeks. MAIN OUTCOME MEASURES obtained from patients treated with TAD-OaD were compared to PBO-treated patients. Additionally, results of treatment with TAD-OaD were compared to results obtained from 4 week PRN-PDE5I therapy to determine whether OaD and PRN regimens provided comparable efficacy. NCT01130532. International Index of Erectile Function (IIEF) domain scores; Sexual Encounter Profile (SEP) questions 2-5. Endpoint data was obtained from 590 men (391 TAD; 199 PBO). RESULTS for all IIEF and SEP measures were significantly better for TAD-OaD (p TAD 2.5 mg and TAD 5 mg OaD therapy were safe and generally well tolerated. Tadalafil once daily is a viable alternative to as-needed PDE5I therapy in men with ED. Key limitations include the lack of a PRN PDE5I study group during the double-blind period, and that many more patients took tadalafil than sildenafil or vardenafil during the PRN period.

Cross-neutralization between three mumps viruses & mapping of haemagglutinin-neuraminidase (HN epitopes

Directory of Open Access Journals (Sweden)

Sunil R Vaidya

2016-01-01

Full Text Available Background & objectives: The reports from the countries where mumps vaccine is given as routine immunization suggest differences in mumps virus neutralizing antibody titres when tested with vaccine and wild type viruses. Such reports are unavailable from countries like India where mumps vaccine is not included in routine immunization. We, therefore, undertook this study to understand the cross-neutralization activity of Indian mumps viruses. Methods: By using commercial mumps IgG enzyme immunoassay (EIA and a rapid focus reduction neutralization test (FRNT, a panel of serum samples was tested. The panel consisted of 14 acute and 14 convalescent serum samples collected during a mumps outbreak and 18 archived serum samples. Two wild types (genotypes C and G and Leningrad-Zagreb vaccine strain (genotype N were used for the challenge experiments and FRNT titres were determined and further compared. The HN protein sequence of three mumps viruses was analyzed for the presence of key epitopes. Results: All serum samples effectively neutralized mumps virus wild types and a vaccine strain. However, significantly lower FRNT titres were noted to wild types than to vaccine strain (P<0.05. The comparison between EIA and FRNT results revealed 95.6 per cent agreement. No amino acid changes were seen in the epitopes in the Indian wild type strains. All potential N-linked glycosylation sites were observed in Indian strains. Interpretation & conclusions:Good cross-neutralization activity was observed for three mumps virus strains, however, higher level of FRNT titres was detected for mumps virus vaccine strain compared to Indian wild type isolates.

Cross-neutralization between three mumps viruses & mapping of haemagglutinin-neuraminidase (HN) epitopes.

Science.gov (United States)

Vaidya, Sunil R; Dvivedi, Garima M; Jadhav, Santoshkumar M

2016-01-01

The reports from the countries where mumps vaccine is given as routine immunization suggest differences in mumps virus neutralizing antibody titres when tested with vaccine and wild type viruses. Such reports are unavailable from countries like India where mumps vaccine is not included in routine immunization. We, therefore, undertook this study to understand the cross-neutralization activity of Indian mumps viruses. By using commercial mumps IgG enzyme immunoassay (EIA) and a rapid focus reduction neutralization test (FRNT), a panel of serum samples was tested. The panel consisted of 14 acute and 14 convalescent serum samples collected during a mumps outbreak and 18 archived serum samples. Two wild types (genotypes C and G) and Leningrad-Zagreb vaccine strain (genotype N) were used for the challenge experiments and FRNT titres were determined and further compared. The HN protein sequence of three mumps viruses was analyzed for the presence of key epitopes. All serum samples effectively neutralized mumps virus wild types and a vaccine strain. However, significantly lower FRNT titres were noted to wild types than to vaccine strain (P<0.05). The comparison between EIA and FRNT results revealed 95.6 per cent agreement. No amino acid changes were seen in the epitopes in the Indian wild type strains. All potential N-linked glycosylation sites were observed in Indian strains. Good cross-neutralization activity was observed for three mumps virus strains, however, higher level of FRNT titres was detected for mumps virus vaccine strain compared to Indian wild type isolates.

Identification of intrinsic catalytic activity for electrochemical reduction of water molecules to generate hydrogen

KAUST Repository

Shinagawa, Tatsuya

2015-01-01

Insufficient hydronium ion activities at near-neutral pH and under unbuffered conditions induce diffusion-limited currents for hydrogen evolution, followed by a reaction with water molecules to generate hydrogen at elevated potentials. The observed constant current behaviors at near neutral pH reflect the intrinsic electrocatalytic reactivity of the metal electrodes for water reduction. This journal is © the Owner Societies.

Phenomenology of neutral current interactions

International Nuclear Information System (INIS)

Sakurai, J.J.

1978-01-01

Neutral-current interactions are discussed within a rather general phenomenological framework without commitment to any particular theoretical model. Three points are kept in mind: what various experiments really measure; the performing of complete experiments to determine the neutral-current couplings; and the testing of models in an objective, emotionally uninvolved manner. The following topics are considered: neutrino-electron scattering, hadronic currents and models, neutrino-induced inclusive hadronic reactions, neutrino-induced exclusive hadronic reactions, and neutral-current phenomena without neutrinos. In conclusion, what has actually been learned about neutral-current interactions is summarized. 9 figures, 2 tables

Settling velocity of quasi-neutrally-buoyant inertial particles

Science.gov (United States)

Martins Afonso, Marco; Gama, Sílvio M. A.

2018-02-01

We investigate the sedimentation properties of quasi-neutrally buoyant inertial particles carried by incompressible zero-mean fluid flows. We obtain generic formulae for the terminal velocity in generic space-and-time periodic (or steady) flows, along with further information for flows endowed with some degree of spatial symmetry such as odd parity in the vertical direction. These expressions consist in space-time integrals of auxiliary quantities that satisfy partial differential equations of the advection-diffusion-reaction type, which can be solved at least numerically, since our scheme implies a huge reduction of the problem dimensionality from the full phase space to the classical physical space. xml:lang="fr"

Molecular clock on a neutral network.

Science.gov (United States)

Raval, Alpan

2007-09-28

The number of fixed mutations accumulated in an evolving population often displays a variance that is significantly larger than the mean (the overdispersed molecular clock). By examining a generic evolutionary process on a neutral network of high-fitness genotypes, we establish a formalism for computing all cumulants of the full probability distribution of accumulated mutations in terms of graph properties of the neutral network, and use the formalism to prove overdispersion of the molecular clock. We further show that significant overdispersion arises naturally in evolution when the neutral network is highly sparse, exhibits large global fluctuations in neutrality, and small local fluctuations in neutrality. The results are also relevant for elucidating aspects of neutral network topology from empirical measurements of the substitution process.

Is a neutral expression also a neutral stimulus? A study with functional magnetic resonance.

Science.gov (United States)

Carvajal, Fernando; Rubio, Sandra; Serrano, Juan M; Ríos-Lago, Marcos; Alvarez-Linera, Juan; Pacheco, Lara; Martín, Pilar

2013-08-01

Although neutral faces do not initially convey an explicit emotional message, it has been found that individuals tend to assign them an affective content. Moreover, previous research has shown that affective judgments are mediated by the task they have to perform. Using functional magnetic resonance imaging in 21 healthy participants, we focus this study on the cerebral activity patterns triggered by neutral and emotional faces in two different tasks (social or gender judgments). Results obtained, using conjunction analyses, indicated that viewing both emotional and neutral faces evokes activity in several similar brain areas indicating a common neural substrate. Moreover, neutral faces specifically elicit activation of cerebellum, frontal and temporal areas, while emotional faces involve the cuneus, anterior cingulated gyrus, medial orbitofrontal cortex, posterior superior temporal gyrus, precentral/postcentral gyrus and insula. The task selected was also found to influence brain activity, in that the social task recruited frontal areas while the gender task involved the posterior cingulated, inferior parietal lobule and middle temporal gyrus to a greater extent. Specifically, in the social task viewing neutral faces was associated with longer reaction times and increased activity of left dorsolateral frontal cortex compared with viewing facial expressions of emotions. In contrast, in the same task emotional expressions distinctively activated the left amygdale. The results are discussed taking into consideration the fact that, like other facial expressions, neutral expressions are usually assigned some emotional significance. However, neutral faces evoke a greater activation of circuits probably involved in more elaborate cognitive processing.

Unconditional conservatism in Brazilian public companies and tax neutrality

Directory of Open Access Journals (Sweden)

Juliana Pinhata Sanches do Vale

2017-03-01

Full Text Available ABSTRACT Law n. 11,638/2007 legitimized the International Financial Reporting Standards (IFRS adoption process in Brazil and introduced an accounting system detached from tax purposes in the country. This law aims to reduce the influence of tax law on accounting standards and improve the quality of financial reporting, as IFRS are considered to be higher quality standards. International literature shows a reduction in earnings quality in environments where accounting and tax rules are strongly linked. Moreover, the influence of tax legislation on financial accounting is seen to encourage unconditional conservatism, a bias with no advantages for financial market efficiency. Thus, tax neutrality is expected to provide a more favorable institutional environment for quality financial reporting by detaching corporate accounting from tax accounting. In light of the above, this study aims to verify whether the advent of tax neutrality influences unconditional conservatism in Brazilian public companies. The methodology used involves panel data regressions. The sample consists of non-financial publicly-traded companies with information published in Economática® covering 2002 to 2014. The results show differences in the relationship between taxation and financial reporting between firms that are subject to different levels of monitoring in the Brazilian stock market. Evidence of unconditional conservatism is only found in companies that are subject to greater market monitoring. In this group, it is observed that taxation does not induce unconditional conservatism in reported earnings, which is expected in a tax neutrality context.

ORNL positive ion neutral beam program

International Nuclear Information System (INIS)

Whealton, J.H.; Haselton, H.H.; Barber, G.C.

1978-01-01

The neutral beam group at Oak Ridge National Laboratory has constructed neutral beam generators for the ORMAK and PLT devices, is presently constructing neutral beam devices for the ISX and PDX devices, and is contemplating the construction of neutral beam systems for the advanced TNS device. These neutral beam devices stem from the pioneering work on ion sources of G. G. Kelley and O. B. Morgan. We describe the ion sources under development at this Laboratory, the beam optics exhibited by these sources, as well as some theoretical considerations, and finally the remainder of the beamline design

A light weight secure image encryption scheme based on chaos & DNA computing

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Bhaskar Mondal

2017-10-01

Full Text Available This paper proposed a new light weight secure cryptographic scheme for secure image communication. In this scheme the plain image is permuted first using a sequence of pseudo random number (PRN and encrypted by DeoxyriboNucleic Acid (DNA computation. Two PRN sequences are generated by a Pseudo Random Number Generator (PRNG based on cross coupled chaotic logistic map using two sets of keys. The first PRN sequence is used for permuting the plain image whereas the second PRN sequence is used for generating random DNA sequence. The number of rounds of permutation and encryption may be variable to increase security. The scheme is proposed for gray label images but the scheme may be extended for color images and text data. Simulation results exhibit that the proposed scheme can defy any kind of attack.

Spontaneous modification of carbon surface with neutral red from its diazonium salts for bioelectrochemical systems.

Science.gov (United States)

Guo, Kun; Chen, Xin; Freguia, Stefano; Donose, Bogdan C

2013-09-15

This study introduces a novel and simple method to covalently graft neutral red (NR) onto carbon surfaces based on spontaneous reduction of in situ generated NR diazonium salts. Immobilization of neutral red on carbon surface was achieved by immersing carbon electrodes in NR-NaNO2-HCl solution. The functionalized electrodes were characterized by cyclic voltammetry (CV), atomic force microscope (AFM), and X-ray photoelectron spectroscopy (XPS). Results demonstrated that NR attached in this way retains high electrochemical activity and proved that NR was covalently bound to the carbon surface via the pathway of reduction of aryl diazonium salts. The NR-modified electrodes showed a good stability when stored in PBS solution in the dark. The current output of an acetate-oxidising microbial bioanode made of NR-modified graphite felts were 3.63±0.36 times higher than the unmodified electrodes, which indicates that covalently bound NR can act as electron transfer mediator to facilitate electron transfer from bacteria to electrodes. Copyright © 2013 Elsevier B.V. All rights reserved.

Gas cell neutralizers (Fundamental principles)

International Nuclear Information System (INIS)

Fuehrer, B.

1985-06-01

Neutralizing an ion-beam of the size and energy levels involved in the neutral-particle-beam program represents a considerable extension of the state-of-the-art of neutralizer technology. Many different mediums (e.g., solid, liquid, gas, plasma, photons) can be used to strip the hydrogen ion of its extra electron. A large, multidisciplinary R and D effort will no doubt be required to sort out all of the ''pros and cons'' of these various techniques. The purpose of this particular presentation is to discuss some basic configurations and fundamental principles of the gas type of neutralizer cell. Particular emphasis is placed on the ''Gasdynamic Free-Jet'' neutralizer since this configuration has the potential of being much shorter than other type of gas cells (in the beam direction) and it could operate in nearly a continuous mode (CW) if necessary. These were important considerations in the ATSU design which is discussed in some detail in the second presentation entitled ''ATSU Point Design''

Design data for calculating neutral beam penetration into Z/sub eff/ > 1 plasmas

International Nuclear Information System (INIS)

Olson, R.E.; Berkner, K.H.; Graham, W.G.; Pyle, R.V.; Schlachter, A.S.; Stearns, J.W.

1978-01-01

Impurities such as C, N, O, Fe, and Mo in a confined plasma reduce the penetration of the energetic neutral deuterium or hydrogen beam injected for heating or fueling the plasma, thus affecting the energy- and fuel-deposition profiles. New calculations, confirmed by recent experimental results, show that previous estimates of the reduction of neutral beam penetration due to impurities in the plasma were overly pessimistic. Until recently, the cross sections used to calculate beam attenuation had been assumed to be q 2 times the cross section for H + + H obtained from the Born approximation, where q is the charge state of the ion. This led to very large cross sections for large values of q, and thus to very stringent requirements on the acceptable level of impurity ions in the plasma

COLLISIONLESS SHOCKS IN A PARTIALLY IONIZED MEDIUM. I. NEUTRAL RETURN FLUX AND ITS EFFECTS ON ACCELERATION OF TEST PARTICLES

Energy Technology Data Exchange (ETDEWEB)

Blasi, P.; Morlino, G.; Bandiera, R.; Amato, E. [INAF-Osservatorio Astrofisico di Arcetri, Largo E. Fermi, 5, I-50125 Firenze (Italy); Caprioli, D. [Department of Astrophysical Sciences, Peyton Hall, Princeton University, Princeton, NJ 08540 (United States)

2012-08-20

A collisionless shock may be strongly modified by the presence of neutral atoms through the processes of charge exchange between ions and neutrals and ionization of the latter. These two processes lead to exchange of energy and momentum between charged and neutral particles both upstream and downstream of the shock. In particular, neutrals that suffer a charge exchange downstream with shock-heated ions generate high-velocity neutrals that have a finite probability of returning upstream. These neutrals might then deposit heat in the upstream plasma through ionization and charge exchange, thereby reducing the fluid Mach number. A consequence of this phenomenon, which we refer to as the neutral return flux, is a reduction of the shock compression factor and the formation of a shock precursor upstream. The scale length of the precursor is determined by the ionization and charge-exchange interaction lengths of fast neutrals moving toward upstream infinity. In the case of a shock propagating in the interstellar medium, the effects of ion-neutral interactions are especially important for shock velocities <3000 km s{sup -1}. Such propagation velocities are common among shocks associated with supernova remnants, the primary candidate sources for the acceleration of Galactic cosmic rays. We then investigate the effects of the return flux of neutrals on the spectrum of test particles accelerated at the shock. We find that, for shocks slower than {approx}3000 km s{sup -1}, the particle energy spectrum steepens appreciably with respect to the naive expectation for a strong shock, namely, {proportional_to}E{sup -2}.

A Carbon-Neutral California: Social Ecology and Prospects for 2050 GHG Reduction

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Stephen M. Wheeler

2017-10-01

Full Text Available How might a large jurisdiction approach carbon neutrality by 2050, and what initiatives might increase the chances of success? This article explores these questions using California as a case study. Current trends as well as multiple modeling studies show that existing policy directions for the state will not be sufficient. Additional initiatives appear needed to accelerate adoption of electric vehicles, reduce driving, reach 100 percent renewable electricity, convert existing buildings to zero-net-carbon status, change diet, and reduce consumption. The state’s social ecology does not currently support such changes. Consequently, planners and other professionals need to consider strategic actions to change social ecology as well as climate policy. Potential steps to do this include raising the price of carbon; revising the state’s tax system so as to increase public sector capacity; developing a stronger framework of incentives, mandates, and technical support between levels of government; and expanding educational and social marketing programs aimed at behavior change. A main implication of this analysis is that in many contexts worldwide sustainability planners should consider action on both policy and social ecology levels to maximize chances of success.

New Modulation Strategy to Balance the Neutral-Point Voltage for Three-Level Neutral-Clamped Inverter Systems

DEFF Research Database (Denmark)

Choi, Uimin; Lee, June-Seok; Lee, Kyo-Beum

2014-01-01

This paper proposes a new modulation strategy that balances the neutral-point voltage for three-level neutral-clamped inverter systems. The proposed modulation replaces the P-type or N-type small switching states with other switching states that do not affect the neutral-point voltage. The zero...... and medium switching states are employed to help the neutral-point voltage balancing. This method little bit increases the switching events and output total harmonic distortion. However, this method has a strong balancing ability at all regions. Further, it is very simple to implement in both space vector...

How Objective a Neutral Word Is? A Neutrosophic Approach for the Objectivity Degrees of Neutral Words

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Mihaela Colhon

2017-11-01

Full Text Available In the latest studies concerning the sentiment polarity of words, the authors mostly consider the positive and negative constructions, without paying too much attention to the neutral words, which can have, in fact, significant sentiment degrees. More precisely, not all the neutral words have zero positivity or negativity scores, some of them having quite important nonzero scores for these polarities. At this moment, in the literature, a word is considered neutral if its positive and negative scores are equal, which implies two possibilities: (1 zero positive and negative scores; (2 nonzero, but equal positive and negative scores. It is obvious that these cases represent two different categories of neutral words that must be treated separately by a sentiment analysis task. In this paper, we present a comprehensive study about the neutral words applied to English as is developed with the aid of SentiWordNet 3.0: the publicly available lexical resource for opinion mining. We designed our study in order to provide an accurate classification of the so-called “neutral words” described in terms of sentiment scores and using measures from neutrosophy theory. The intended scope is to fill the gap concerning the neutrality aspect by giving precise measurements for the words’ objectivity.

Mixed deuterium-tritium neutral beam injection

International Nuclear Information System (INIS)

Ruby, L.; Lewis, M.S.

1989-01-01

An alternative mixed beam neutral beam injector (MNBI) for fusion reactors is proposed that eliminates the conventional isotope separation system (ISS) in the fuel cycle. The principal advantage of the alternative system is a capital and operating cost savings in the fuel cycle, as the ISS employs cryogenic distillation at liquid-hydrogen temperatures to effect a separation of hydrogen isotopes and to eliminate a buildup of normal hydrogen in the recycled fuel. Possible additional advantages of the alternative method involve an improvement in overall safety and a reduction of the amount of tritium in the fuel cycle. The alternative heating system uses an electromagnetic separation in the MNBI to limit the buildup of normal hydrogen. Calculations indicate that an MNBI can be reasonably optimized in the case of an upgraded injection system for the Tokamak Fusion Test Reactor

Neutral-beam-heating applications and development

International Nuclear Information System (INIS)

Menon, M.M.

1981-01-01

The technique of heating the plasma in magnetically confined fusion devices by the injection of intense beams of neutral atoms is described. The basic principles governing the physics of neutral beam heating and considerations involved in determining the injection energy, power, and pulse length required for a fusion reactor are discussed. The pertinent experimental results from various fusion devices are surveyed to illustrate the efficacy of this technique. The second part of the paper is devoted to the technology of producing the neutral beams. A state-of-the-art account o the development of neutral injectors is presented, and the prospects for utilizing neutral injection to heat the plasma in a fusion reactor are examined

Neutral-point current modeling and control for Neutral-Point Clamped three-level converter drive with small DC-link capacitors

DEFF Research Database (Denmark)

Maheshwari, Ram Krishan; Munk-Nielsen, Stig; Busquets-Monge, Sergio

2011-01-01

A Neutral-Point-Clamped (NPC) three-level inverter with small DC-link capacitors is presented in this paper. This inverter requires zero average neutral-point current for stable neutral-point potential. A simple carrier based modulation strategy is proposed for achieving zero average neutral...... drive with only 14 μF DC-link capacitors. A fast and stable performance of the neutral-point voltage controller is achieved and verified by experiments....

Synthesis of amino ester-embedded benzimidazoles: a one-pot sequential protocol under metal-free neutral conditions.

Science.gov (United States)

Roy, Priyabrata; Bodhak, Chandan; Pramanik, Animesh

2017-02-01

A one-pot three-component protocol has been developed for the synthesis of amino ester-embedded benzimidazoles under metal-free neutral conditions. Sequentially, the methodology involves coupling of an amino ester with 1-fluoro-2-nitrobenzene, reduction of the coupled nitroarene by sodium dithionite, and cyclization of the corresponding diamine with an aldehyde.

Net neutrality and audiovisual services

OpenAIRE

van Eijk, N.; Nikoltchev, S.

2011-01-01

Net neutrality is high on the European agenda. New regulations for the communication sector provide a legal framework for net neutrality and need to be implemented on both a European and a national level. The key element is not just about blocking or slowing down traffic across communication networks: the control over the distribution of audiovisual services constitutes a vital part of the problem. In this contribution, the phenomenon of net neutrality is described first. Next, the European a...

Screening test for neutralizing antibodies against yellow fever virus, based on a flavivirus pseudotype.

Directory of Open Access Journals (Sweden)

Séverine Mercier-Delarue

Full Text Available Given the possibility of yellow fever virus reintroduction in epidemiologically receptive geographic areas, the risk of vaccine supply disruption is a serious issue. New strategies to reduce the doses of injected vaccines should be evaluated very carefully in terms of immunogenicity. The plaque reduction test for the determination of neutralizing antibodies (PRNT is particularly time-consuming and requires the use of a confinement laboratory. We have developed a new test based on the use of a non-infectious pseudovirus (WN/YF17D. The presence of a reporter gene allows sensitive determination of neutralizing antibodies by flow cytometry. This WN/YF17D test was as sensitive as PRNT for the follow-up of yellow fever vaccinees. Both tests lacked specificity with sera from patients hospitalized for acute Dengue virus infection. Conversely, both assays were strictly negative in adults never exposed to flavivirus infection or vaccination, and in patients sampled some time after acute Dengue infection. This WN/YF17D test will be particularly useful for large epidemiological studies and for screening for neutralizing antibodies against yellow fever virus.

Electromagnetic trapping of neutral atoms

International Nuclear Information System (INIS)

Metcalf, H.J.

1986-01-01

Cooling and trapping of neutral atoms is a new branch of applied physics that has potential for application in many areas. The authors present an introduction to laser cooling and magnetic trapping. Some basic ideas and fundamental limitations are discussed, and the first successful experiments are reviewed. Trapping a neutral object depends on the interaction between an inhomogeneous electromagnetic field and a multiple moment that results in the exchange of kinetic for potential energy. In neutral atom traps, the potential energy must be stored as internal atomic energy, resulting in two immediate and extremely important consequences. First, the atomic energy levels will necessarily shift as the atoms move in the trap, and, second, practical traps for ground state neutral atoms atr necessarily very shallow compared to thermal energy. This small depth also dictates stringent vacuum requirements because a trapped atom cannot survive a single collision with a thermal energy background gas molecule. Neutral trapping, therefore, depends on substantial cooling of a thermal atomic sample and is inextricably connected with the cooling process

Plasma neutralizers for H- or D- beams

International Nuclear Information System (INIS)

Berkner, K.H.; Pyle, R.V.; Savas, S.E.; Stalder, K.R.

1980-10-01

Plasma neutralizers can produce higher conversion efficiencies than are obtainable with gas neutralizers for the production of high-energy neutral beams from negative hydrogen ions. Little attention has been paid to experimental neutralizer studies because of the more critical problems connected with the development of negative-ion sources. With the prospect of accelerating ampere dc beams from extrapolatable ion sources some time next year, we are re-examining plasma neutralizers. Some basic considerations, two introductory experiments, and a next-step experiment are described

Selection of Clostridium spp. in biological sand filters neutralizing synthetic acid mine drainage.

Science.gov (United States)

Ramond, Jean-Baptiste; Welz, Pamela J; Le Roes-Hill, Marilize; Tuffin, Marla I; Burton, Stephanie G; Cowan, Don A

2014-03-01

In this study, three biological sand filter (BSF) were contaminated with a synthetic iron- [1500 mg L⁻¹ Fe(II), 500 mg L⁻¹ Fe(III)] and sulphate-rich (6000 mg L⁻¹ SO₄²⁻) acid mine drainage (AMD) (pH = 2), for 24 days, to assess the remediation capacity and the evolution of autochthonous bacterial communities (monitored by T-RFLP and 16S rRNA gene clone libraries). To stimulate BSF bioremediation involving sulphate-reducing bacteria, a readily degradable carbon source (glucose, 8000 mg L⁻¹) was incorporated into the influent AMD. Complete neutralization and average removal efficiencies of 81.5 (±5.6)%, 95.8 (±1.2)% and 32.8 (±14.0)% for Fe(II), Fe(III) and sulphate were observed, respectively. Our results suggest that microbial iron reduction and sulphate reduction associated with iron precipitation were the main processes contributing to AMD neutralization. The effect of AMD on BSF sediment bacterial communities was highly reproducible. There was a decrease in diversity, and notably a single dominant operational taxonomic unit (OTU), closely related to Clostridium beijerinckii, which represented up to 65% of the total community at the end of the study period. © 2013 Federation of European Microbiological Societies. Published by John Wiley & Sons Ltd. All rights reserved.

Ion-beam Plasma Neutralization Interaction Images

Energy Technology Data Exchange (ETDEWEB)

Igor D. Kaganovich; Edward Startsev; S. Klasky; Ronald C. Davidson

2002-04-09

Neutralization of the ion beam charge and current is an important scientific issue for many practical applications. The process of ion beam charge and current neutralization is complex because the excitation of nonlinear plasma waves may occur. Computer simulation images of plasma neutralization of the ion beam pulse are presented.

Ion-beam Plasma Neutralization Interaction Images

International Nuclear Information System (INIS)

Igor D. Kaganovich; Edward Startsev; S. Klasky; Ronald C. Davidson

2002-04-01

Neutralization of the ion beam charge and current is an important scientific issue for many practical applications. The process of ion beam charge and current neutralization is complex because the excitation of nonlinear plasma waves may occur. Computer simulation images of plasma neutralization of the ion beam pulse are presented

Improved survival in rhesus macaques immunized with modified vaccinia virus Ankara recombinants expressing simian immunodeficiency virus envelope correlates with reduction in memory CD4+ T-cell loss and higher titers of neutralizing antibody.

Science.gov (United States)

Ourmanov, Ilnour; Kuwata, Takeo; Goeken, Robert; Goldstein, Simoy; Iyengar, Ranjani; Buckler-White, Alicia; Lafont, Bernard; Hirsch, Vanessa M

2009-06-01

Previous studies demonstrated that immunization of macaques with simian immunodeficiency virus (SIV) Gag-Pol and Env recombinants of the attenuated poxvirus modified vaccinia virus Ankara (MVA) provided protection from high viremia and AIDS following challenge with a pathogenic strain of SIV. Although all animals became infected, plasma viremia was significantly reduced in animals that received the MVA-SIV recombinant vaccines compared with animals that received nonrecombinant MVA. Most importantly, the reduction in viremia resulted in a significant increase in median and cumulative survival. Continued analysis of these animals over the subsequent 9 years has shown that they maintain a survival advantage, although all but two of the macaques have progressed to AIDS. Importantly, improved survival correlated with preservation of memory CD4(+) T cells in the peripheral blood. The greatest survival advantage was observed in macaques immunized with regimens containing SIV Env, and the titer of neutralizing antibodies to the challenge virus prior to or shortly following challenge correlated with preservation of CD4(+) T cells. These data are consistent with a role for neutralizing antibodies in nonsterilizing protection from high viremia and associated memory CD4(+) T-cell loss.

Global Model of Time-Modulated Electronegative Discharges for Neutral Radical and Electron Temperature Control

Science.gov (United States)

Kim, Sungjin; Lieberman, M. A.; Lichtenberg, A. J.

2003-10-01

Control and reduction of neutral radical flux/ion flux ratio and electron temperature Te is required for next generation etching in the microelectronics industry. We investigate time-modulated power for these purposes using a volume-averaged (global) oxygen discharge model, We consider pressures of 10-50 mTorr and plasma densities of 10^10-10^11 cm-3. In this regime, the discharge is found to be weakly electronegative. The modulation period and the duty ratio (on-time/period) are varied to determine the optimum conditions for reduction of FR= O-atom flux/ion flux and T_e. Two chambers with different height/diameter ratios (SMART Contract SM99-10051.

Tax Neutrality on International Capital Investments

Directory of Open Access Journals (Sweden)

Gizem KAPUCU

2017-07-01

Full Text Available The tax policies which states follow with regard to developing technology and capital investments with raising mobility due to globalism are need to be discussed in its legal basis. The principle of tax neutrality has the aim of being legal foundation for these policies. According to this, the neutrality principle in taxation of international capital investments is provided with two measures, namely; not effecting the investment decision and not discriminate between investments. In this paper, initially focused on the conceptual framework and the foundations of the tax neutrality principle and later capital export neutrality and capital import neutrality are considered and explained with regard to international capital movements. Moreover, conformity and diversion to the principle of the current situation and regulations in OECD, EU and Turkey are examined.

The Net Neutrality Debate: The Basics

Science.gov (United States)

Greenfield, Rich

2006-01-01

Rich Greenfield examines the basics of today's net neutrality debate that is likely to be an ongoing issue for society. Greenfield states the problems inherent in the definition of "net neutrality" used by Common Cause: "Network neutrality is the principle that Internet users should be able to access any web content they choose and…

Neutral particle kinetics in fusion devices

International Nuclear Information System (INIS)

Tendler, M.; Heifetz, D.

1986-05-01

The theory of neutral particle kinetics treats the transport of mass, momentum, and energy in a plasma due to neutral particles which themselves are unaffected by magnetic fields. This transport affects the global power and particle balances in fusion devices, as well as profile control and plasma confinement quality, particle and energy fluxes onto device components, performance of pumping systems, and the design of diagnostics and the interpretation of their measurements. This paper reviews the development of analytic, numerical, and Monte Carlo methods of solving the time-independent Boltzmann equation describing neutral kinetics. These models for neutral particle behavior typically use adaptations of techniques developed originally for computing neutron transport, due to the analogy between the two phenomena, where charge-exchange corresponds to scattering and ionization to absorption. Progress in the field depends on developing multidimensional analytic methods, and obtaining experimental data for the physical processes of wall reflection, the neutral/plasma interaction, and for processes in fusion devices which are directly related to neutral transport, such as H/sub α/ emission rates, plenum pressures, and charge-exchange emission spectra

Neutral particle kinetics in fusion devices

Energy Technology Data Exchange (ETDEWEB)

Tendler, M.; Heifetz, D.

1986-05-01

The theory of neutral particle kinetics treats the transport of mass, momentum, and energy in a plasma due to neutral particles which themselves are unaffected by magnetic fields. This transport affects the global power and particle balances in fusion devices, as well as profile control and plasma confinement quality, particle and energy fluxes onto device components, performance of pumping systems, and the design of diagnostics and the interpretation of their measurements. This paper reviews the development of analytic, numerical, and Monte Carlo methods of solving the time-independent Boltzmann equation describing neutral kinetics. These models for neutral particle behavior typically use adaptations of techniques developed originally for computing neutron transport, due to the analogy between the two phenomena, where charge-exchange corresponds to scattering and ionization to absorption. Progress in the field depends on developing multidimensional analytic methods, and obtaining experimental data for the physical processes of wall reflection, the neutral/plasma interaction, and for processes in fusion devices which are directly related to neutral transport, such as H/sub ..cap alpha../ emission rates, plenum pressures, and charge-exchange emission spectra.

Neutral beam program

International Nuclear Information System (INIS)

Anon.

1979-01-01

The structure of the beam injection program for the Doublet-3 device is discussed. The design considerations for the beam line and design parameters for the Doublet-3 ion souce are given. Major components of the neutral beam injector system are discussed in detail. These include the neutralizer, magnetic shielding, reflecting magnets, vacuum system, calorimeter and beam dumps, and drift duct. The planned location of the two-injector system for Doublet-3 is illustrated and site preparation is considered. The status of beamline units 1 and 2 and the future program schedule are discussed

Neutral strange particle production in π+/K+p interactions at 250 GeV/c

International Nuclear Information System (INIS)

Scholten, A.J.

1988-01-01

This thesis in which a detailed study of K n inclusive production in K + p and π + p interactions at 250 GeV/c is presented, concentrates on neutral strange interaction products and draws some conclusions about the fate of the strange quark. In ch. 2 the experimental setup is described and in ch. 3 the series of computer programs that perform data reduction. Ch. 4 deals with the selectionn of events and neutral kaons. Also the calculations needed to correct for losses and background are described there. In ch. 5 inclusive and semi-inclusive distributions are presented and compared to data obtained in experiments at lower beam energy. In ch. 6 the data are compared with model predictions. In ch. 7 the main conclusions are summarized. (H.W.). 64 refs.; 39 refs.; 19 tabs

ORNL neutral-beam program in 1978

International Nuclear Information System (INIS)

Whealton, J.H.

1982-12-01

This report was presented at the ion source workshop held at Culham Laboratory, Abingdon, Oxfordshire, in 1978. Because the proceedings of that conference are unavailable, and because the material in this report is still not to be found elsewhere, it is issued as a laboratory report. The neutral beam group at Oak Ridge National Laboratory has constructed neutral beam generators for the ORMAK and PLT devices, is presently constructing neutral beam devices for the ISX and PDX devices, and is contemplating the construction of neutral beam systems for the advanced TNS device. These neutral beam devices stem from the pioneering work on ion sources of G.G. Kelley and O.B. Morgan. We describe the ion sources under development at this laboratory, the beam optics exhibited by these sources, as well as some theoretical considerations, and finally the remainder of the beamline design

Neutral-beam current drive in tokamaks

International Nuclear Information System (INIS)

Devoto, R.S.

1986-01-01

The theory of neutral-beam current drive in tokamaks is reviewed. Experiments are discussed where neutral beams have been used to drive current directly and also indirectly through neoclassical effects. Application of the theory to an experimental test reactor is described. It is shown that neutral beams formed from negative ions accelerated to 500 to 700 keV are needed for this device

Neutral-beam current drive in tokamaks

International Nuclear Information System (INIS)

Devoto, R.S.

1987-01-01

The theory of neutral-beam current drive in tokamaks is reviewed. Experiments are discussed where neutral beams have been used to drive current directly and also indirectly through neoclassical effects. Application of the theory to an experimental test reactor is described. It is shown that neutral beams formed from negative ions accelerated to 500-700 keV are needed for this device

Cyclic voltammetric study of electro-oxidation of methanol on platinum electrode in acidic and neutral media

International Nuclear Information System (INIS)

Khan, A.S.A.; Ahmed, R.; Mirza, M.L.

2007-01-01

The electro-oxidation of methanol on electrochemically treated platinum foil was investigated in acidic and neutral media for comparison of cyclic voltammetric characteristics and elucidation of mechanism of electro-oxidation of methanol. The surface area and roughness factor of platinum electrode was calculated. The electro-oxidation of mathanol is an irreversible process giving. anodic peaks in both anodic and cathodic sweep. The characteristic peaks of electrooxidation of methanol appeared at almost the same potential region in both acidic and neutral media. In neutral medium, certain additional cathodic/anodic peaks appeared which were confirmed to arise by the reduction/oxidation of hydrogen ions. The exchange current density and heterogeneous electron transfer rate constant was higher in neutral medium as. compared with acidic medium. The thermodynamic parameters delta H, delta S, and delta G/sub 298/ were calculated. The values of delta H and delta G/sub 298/were positive which indicated that the process of electro-oxidation of methanol is an endothermic and nonspontaneous. The mechanism of electro-oxidation of methanol was same in both acidic and neutral media involving the formation of various adsorbed intermediate species through dissociative adsorption steps leading to the formation of Co adsorbed radicals, which are removed. during interaction with adsorbed hydrous oxides provided by the oxidation of adsorbed water molecules. The higher rate of electro-oxidation of methanol in neutral medium was interpreted in the tight of electrochemical mechanism and was attributed to the presence of comparatively small amount of hydrogen ions only along the surface of working electrode, which are produced during electro-oxidation of methanol. (author)

Neutral beam in ALVAND IIC tokamak

International Nuclear Information System (INIS)

Ghrannevisse, M.; Moradshahi, M.; Avakian, M.

1992-01-01

Neutral beams have a wide application in tokamak experiments. It used to heat; fuel; adjust electric potentials in plasmas and diagnose particles densities and momentum distributions. It may be used to sustain currents in tokamaks to extend the pulse length. A 5 KV; 500 mA ion source has been constructed by plasma physics group, AEOI and it used to produce plasma and study the plasma parameters. Recently this ion source has been neutralized and it adapted to a neutral beam source; and it used to heat a cylindrical DC plasma and the plasma of ALVAND IIC Tokamak which is a small research tokamak with a minor radius of 12.6 cm, and a major radius of 45.5 cm. In this paper we report the neutralization of the ion beam and the results obtained by injection of this neutral beam into plasmas. (author) 2 refs., 4 figs

Investigation of hydrogen peroxide reduction reaction on graphene and nitrogen doped graphene nanoflakes in neutral solution

Science.gov (United States)

Amirfakhri, Seyed Javad; Binny, Dustin; Meunier, Jean-Luc; Berk, Dimitrios

2014-07-01

H2O2 reduction reaction (HPRR) is studied on both graphene (GNF) and nitrogen doped graphene nanoflakes in 0.1 M Na2SO4 solution by rotating disk electrode. The XPS results indicate that N-doped graphene nanoflakes with high nitrogen content, 32 at%N (N-GNF32), are synthesised successfully by an inductively-coupled thermal plasma (ICP) reactor. Pyridinic, pyrrolic and graphitic N species contribute up to 67% of the total nitrogen. Kinetic parameters such as Tafel slope and stoichiometric number suggest that HPRR occurs by the same mechanism on both GNF and N-GNF32. Although nitrogen does not change the mechanism of HPRR, the results indicate that the reaction rate of H2O2 reduction is enhanced on N-GNF32. The exchange current density of H2O2 reduction based on the active surface area of N-GNF32 is (8.3 ± 0.3) × 10-9 A cm-2, which is 6 times higher than the value determined for GNF. The apparent number of electrons involved in the process suggests that H2O2 decomposition competes with H2O2 reduction on both catalysts. Evaluation of the apparent heterogeneous reaction rate constant and the Tafel slope indicate that simultaneous reduction of O2 and H2O2 is negligible on the N-GNF32. On the other hand, the reduction of O2 and H2O2 occurs simultaneously on the GNF surface.

Structural Basis for Differential Neutralization of Ebolaviruses

Directory of Open Access Journals (Sweden)

John M. Dye

2012-04-01

Full Text Available There are five antigenically distinct ebolaviruses that cause hemorrhagic fever in humans or non-human primates (Ebola virus, Sudan virus, Reston virus, Taï Forest virus, and Bundibugyo virus. The small handful of antibodies known to neutralize the ebolaviruses bind to the surface glycoprotein termed GP1,2. Curiously, some antibodies against them are known to neutralize in vitro but not protect in vivo, whereas other antibodies are known to protect animal models in vivo, but not neutralize in vitro. A detailed understanding of what constitutes a neutralizing and/or protective antibody response is critical for development of novel therapeutic strategies. Here, we show that paradoxically, a lower affinity antibody with restricted access to its epitope confers better neutralization than a higher affinity antibody against a similar epitope, suggesting that either subtle differences in epitope, or different characteristics of the GP1,2 molecules themselves, confer differential neutralization susceptibility. Here, we also report the crystal structure of trimeric, prefusion GP1,2 from the original 1976 Boniface variant of Sudan virus complexed with 16F6, the first antibody known to neutralize Sudan virus, and compare the structure to that of Sudan virus, variant Gulu. We discuss new structural details of the GP1-GP2 clamp, thermal motion of various regions in GP1,2 across the two viruses visualized, details of differential interaction of the crystallized neutralizing antibodies, and their relevance for virus neutralization.

The merits of neutral theory

NARCIS (Netherlands)

Alonso, D.; Etienne, R.S.; McKane, A.J.

2006-01-01

Hubbell's neutral theory of biodiversity has challenged the classic niche-based view of ecological community structure. Although there have been many attempts to falsify Hubbell's theory, we argue that falsification should not lead to rejection, because there is more to the theory than neutrality

Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein.

Science.gov (United States)

Zhang, Xinsheng; Wallace, Olivia L; Domi, Arban; Wright, Kevin J; Driscoll, Jonathan; Anzala, Omu; Sanders, Eduard J; Kamali, Anatoli; Karita, Etienne; Allen, Susan; Fast, Pat; Gilmour, Jill; Price, Matt A; Parks, Christopher L

2015-08-01

Serum was analyzed from 146 healthy adult volunteers in eastern Africa to evaluate measles virus (MV) and canine distemper virus (CDV) neutralizing antibody (nAb) prevalence and potency. MV plaque reduction neutralization test (PRNT) results indicated that all sera were positive for MV nAbs. Furthermore, the 50% neutralizing dose (ND50) for the majority of sera corresponded to antibody titers induced by MV vaccination. CDV nAbs titers were low and generally were detected in sera with high MV nAb titers. A mutant CDV was generated that was less sensitive to neutralization by human serum. The mutant virus genome had 10 nucleotide substitutions, which coded for single amino acid substitutions in the fusion (F) and hemagglutinin (H) glycoproteins and two substitutions in the large polymerase (L) protein. The H substitution occurred in a conserved region involved in receptor interactions among morbilliviruses, implying that this region is a target for cross-reactive neutralizing antibodies. Copyright © 2015 Elsevier Inc. All rights reserved.

Neutral evolution of mutational robustness

NARCIS (Netherlands)

Nimwegen, Erik van; Crutchfield, James P.; Huynen, Martijn

1999-01-01

We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population s limit distribution on the neutral network is solely determined by the network topology and given by the principal eigenvector of the network

Heavy neutral leptons at FASER

Science.gov (United States)

Kling, Felix; Trojanowski, Sebastian

2018-05-01

We study the prospects for discovering heavy neutral leptons at Forward Search Experiment (FASER), the newly proposed detector at the LHC. Previous studies showed that a relatively small detector with ˜10 m length and ≲1 m2 cross sectional area can probe large unconstrained parts of parameter space for dark photons and dark Higgs bosons. In this work, we show that FASER will also be sensitive to heavy neutral leptons that have mixing angles with the active neutrinos that are up to an order of magnitude lower than current bounds. In particular, this is true for heavy neutral leptons produced dominantly in B -meson decays, in which case FASER's discovery potential is comparable to the proposed SHiP detector. We also illustrate how the search for heavy neutral leptons at FASER will be complementary to ongoing searches in high-pT experiments at the LHC and can shed light on the nature of dark matter and the process of baryogenesis in the early Universe.

The Neutral Interest Rate: Estimates for Chile

OpenAIRE

Rodrigo Fuentes S; Fabián Gredig U.

2008-01-01

To estimate the neutral real interest rate for Chile, we use a variety of methods that can be classified into three categories: those derived from economic theory, the neutral rate implicit in financial assets, and statistical procedures using macroeconomic data. We conclude that the neutral rate is not constant over time, but it is closely related with—though not equivalent to—the potential GDP growth rate. The application of the different methods yields fairly similar results. The neutral r...

A potent human neutralizing antibody Fc-dependently reduces established HBV infections.

Science.gov (United States)

Li, Dan; He, Wenhui; Liu, Ximing; Zheng, Sanduo; Qi, Yonghe; Li, Huiyu; Mao, Fengfeng; Liu, Juan; Sun, Yinyan; Pan, Lijing; Du, Kaixin; Ye, Keqiong; Li, Wenhui; Sui, Jianhua

2017-09-26

Hepatitis B virus (HBV) infection is a major global health problem. Currently-available therapies are ineffective in curing chronic HBV infection. HBV and its satellite hepatitis D virus (HDV) infect hepatocytes via binding of the preS1 domain of its large envelope protein to sodium taurocholate cotransporting polypeptide (NTCP). Here, we developed novel human monoclonal antibodies that block the engagement of preS1 with NTCP and neutralize HBV and HDV with high potency. One antibody, 2H5-A14, functions at picomolar level and exhibited neutralization-activity-mediated prophylactic effects. It also acts therapeutically by eliciting antibody-Fc-dependent immunological effector functions that impose durable suppression of viral infection in HBV-infected mice, resulting in reductions in the levels of the small envelope antigen and viral DNA, with no emergence of escape mutants. Our results illustrate a novel antibody-Fc-dependent approach for HBV treatment and suggest 2H5-A14 as a novel clinical candidate for HBV prevention and treatment of chronic HBV infection.

Modeling Secondary Neutral Helium in the Heliosphere

International Nuclear Information System (INIS)

Müller, Hans-Reinhard; Möbius, Eberhard; Wood, Brian E.

2016-01-01

An accurate, analytic heliospheric neutral test-particle code for helium atoms from the interstellar medium (ISM) is coupled to global heliospheric models dominated by hydrogen and protons from the solar wind and the ISM. This coupling enables the forward-calculation of secondary helium neutrals from first principles. Secondaries are produced predominantly in the outer heliosheath, upwind of the heliopause, by charge exchange of helium ions with neutral atoms. The forward model integrates the secondary production terms along neutral trajectories and calculates the combined neutral helium phase space density in the innermost heliosphere where it can be related to in-situ observations. The phase space density of the secondary component is lower than that of primary neutral helium, but its presence can change the analysis of primaries and the ISM, and can yield valuable insight into the characteristics of the plasma in the outer heliosheath. (paper)

Neutral particle beam alternative concept for ITER

International Nuclear Information System (INIS)

Sedgley, D.; Brook, J.; Luzzi, T.; Deutsch, L.

1989-01-01

An analysis of an ITER neutral particle beam system is presented. The analysis covers the neutralizer, ion dumps, pumping, and geometric aspects. The US beam concept for ITER consists of three or four clusters of beamlines delivering approximately 80 MW total of 1.6-MeV deuterium to three or four reactor ports. Each cluster has three self-contained beamlines featuring plasma neutralizers and electrostatic ion dumps. In this study, each of the beamlines has two source assemblies with separate gas neutralizers and magnetic ion dumps. Deuterium is injected into the gas neutralizers by a separate system. Saddle-shaped copper coils augment the tokamak poloidal field to turn the charged particles into the ion dumps. The gas flow from the source, neutralizer, and ion dump is pumped by regenerable cryopanels. The effect of the port between the TF coils and the beam injection angle on the plasma footprint was studied

Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats.

Science.gov (United States)

Kading, Rebekah C; Kityo, Robert M; Mossel, Eric C; Borland, Erin M; Nakayiki, Teddie; Nalikka, Betty; Nyakarahuka, Luke; Ledermann, Jeremy P; Panella, Nicholas A; Gilbert, Amy T; Crabtree, Mary B; Peterhans, Julian Kerbis; Towner, Jonathan S; Amman, Brian R; Sealy, Tara K; Nichol, Stuart T; Powers, Ann M; Lutwama, Julius J; Miller, Barry R

2018-01-01

Introduction: A number of arboviruses have previously been isolated from naturally-infected East African bats, however the role of bats in arbovirus maintenance is poorly understood. The aim of this study was to investigate the exposure history of Ugandan bats to a panel of arboviruses. Materials and methods: Insectivorous and fruit bats were captured from multiple locations throughout Uganda during 2009 and 2011-2013. All serum samples were tested for neutralizing antibodies against West Nile virus (WNV), yellow fever virus (YFV), dengue 2 virus (DENV-2), Zika virus (ZIKV), Babanki virus (BBKV), and Rift Valley fever virus (RVFV) by plaque reduction neutralization test (PRNT). Sera from up to 626 bats were screened for antibodies against each virus. Results and Discussion:  Key findings include the presence of neutralizing antibodies against RVFV in 5/52 (9.6%) of little epauletted fruit bats ( Epomophorus labiatus ) captured from Kawuku and 3/54 (5.6%) Egyptian rousette bats from Kasokero cave. Antibodies reactive to flaviviruses were widespread across bat taxa and sampling locations. Conclusion: The data presented demonstrate the widespread exposure of bats in Uganda to arboviruses, and highlight particular virus-bat associations that warrant further investigation.

An experimenter's history of neutral currents

International Nuclear Information System (INIS)

Sciulli, F.

1979-01-01

The history of the experimental study of neutral currents, defined as the class of weak interactions engaged in by lepton pairs of net zero charge, is traced under the headings; historical motivations, experimental searches, first positive indications, neutral currents corroborated, neutrino experiments on neutral currents and some general experimental comments. It is concluded that the neutral current does exist and predicted on the basis of gauge theory ideas, and though to connect the weak and electromagnetic interactions, its very general experimental properties are quite consistent with those ideas. Among these are flavor conserving complicated isospin structure, complicated V, A structure and a structure which depends on the type (or quantum numbers) of the target. 50 references. (UK)

Computational study of the first stage of hypersonic ion beam neutralization: The cross neutralization stage

International Nuclear Information System (INIS)

Pomot, C.; Dolique, J.M.

1975-01-01

A study is made of the first stage of evolution of a hypersonic ion beam in which thermoelectrons are emitted by a heated grid, known as the neutralizer. Downstream from the neutralizer there appears successively as a sheath a range of periodic and quasi-stationary electric field and a front where the electric field oscillates with the plasma frequency. The sheath is self-regulated. Some electrons are trapped in the periodic and stationary electric field. The characteristics of the periodic, quasi-stationary range correspond to those of both an experimental study and one-dimensional time-independent macroscopic theory. This quasi-stationary regime builds up in a time smaller than ω/subp/e -1 and is studied for a few periods ω/subP//sube/ -1 . The subsequent evolution of this state of nonequilibrium is not investigated. The experimental study has shown that, as for the neutralization of a subsonic ion beam, it leads to a field-free, homogeneous medium: a ''synthesized plasma.'' The importance of the first stage described herein, which may be called the gross neutralization stage, is due to the properties of mean neutrality in the current and in the charge insured by the regulating sheath, properties which will be preseved downstream

Passivation behavior of SUS 304 stainless steel in neutral solutions at elevated temperature

International Nuclear Information System (INIS)

Tanno, Kazuo; Kato, Koji; Ohnaka, Noriyuki; Okajima, Yoshiaki; Minato, Akira.

1981-01-01

Cyclic voltammograms of SUS 304 stainless steel in various neutral solutions such as Na 2 SO 4 at high temperature were measured, as a successive study to previous report in which effects of temperature and pH on polarization behavior of stainless steel were studied. In this measurement Ag/AgCl reference electrode and platinum counter electrode were used in a static autoclave lined with inconel. Passive films formed in various conditions were analysed by electron diffraction and Auger spectroscopy. Results obtained were compared with anodic behavior of iron, chromium and nickel and with thermodynamical stabilities of their compounds. The main results are summarized as follows. (1) Stainless steel shows such electrochemical behavior as active dissolution, passivation and transpassivation in a deaerated neutral solution at 250 0 C after fully reductive treatment of the specimen. In air-saturated solution, the peak of active dissolution is not observed. In the passive range there are intermediate oxidation and reduction peaks, and it is assumed that dissolved ionic species are oxidized to form oxide of spinel type and higher oxidized state successively at these peaks. (2) Electrochemical behavior of specimens in 0.1 M sulfate, -phosphate and -carbonate solutions are almost the same and rather thick films form in these solutions. On the other hand, specimens are easy to passivate in borate and -nitrate solution, and their passive films are thin. (author)

Net neutrality and audiovisual services

NARCIS (Netherlands)

van Eijk, N.; Nikoltchev, S.

2011-01-01

Net neutrality is high on the European agenda. New regulations for the communication sector provide a legal framework for net neutrality and need to be implemented on both a European and a national level. The key element is not just about blocking or slowing down traffic across communication

Computerized operation of the DIII-D neutral beams

International Nuclear Information System (INIS)

Glad, A.S.; Tooker, J.F.

1986-01-01

Operation of the DIII-D neutral beams utilizes computerized control to provide routine tokamak beam heating shots and an effective method for automatic ion source operation. Computerized control reduces operational complexity, thus providing consistent reliability and availability of beams and a significant reduction in the the costs of routine operation. The objectives in implementing computerized control for operation were: (1) to improve operator efficiency for controlling multiple beam lines and increasing beam availability through standard procedures, (2) to provide a simplified scheme that operators and coordinators can construct and maintain, and (3) to provide a single integrated mechanism for both tokamak operation and automatic source conditioning. The years of experience in operating neutral beams at Doublet III provided the data necessary to meet the objectives. The method for computerized control consisted of three integrated functions: (1) a structured command language was implemented to provide the mechanism for automatically sequencing beams, (2) a historical file was constructed from the operational parameters to characterize the ion source, and consists of data from approximately 100,000 beam shots, and (3) procedures were developed integrating the language to the historical file for normal operation and source conditioning. This paper describes the method for sequencing beams automatically, the structure of the historical data file, and the procedures which integrate the historical data with tokamak operation and automatic source conditioning

Energizing and depletion of neutrals by a collisional plasma

International Nuclear Information System (INIS)

Fruchtman, A

2008-01-01

Neutral depletion can significantly affect the steady state of low temperature plasmas. Recent theoretical analyses predicted previously unexpected effects of neutral depletion in both collisional and collisionless regimes. In this paper we address the effect of the energy deposited in the neutral gas by a collisional plasma. The fraction of power deposited in the neutrals is shown to be independent of the amount of power. The first case we address is of a thermalized neutral gas. It is shown that a low heat conductivity of the neutral gas is followed by a high neutral temperature that results in a high neutral depletion even if the plasma pressure is small. In the second case neutrals are accelerated through charge exchange with ions leading to what we call neutral pumping, which is equivalent to ion pumping in a collisionless plasma. Neutral depletion is found in the second case for both a closed system (no net mass flow) and an open system (a finite mass flow). A thruster that employs a collisional plasma and pumped neutrals is compared with the thruster analyzed before that employs collisionless plasma.

Net Neutrality: Media Discourses and Public Perception

Directory of Open Access Journals (Sweden)

Christine Quail

2010-01-01

Full Text Available This paper analyzes media and public discourses surrounding net neutrality, with particular attention to public utility philosophy, from a critical perspective. The article suggests that further public education about net neutrality would be beneficial. The first portion of this paper provides a survey of the existing literature surrounding net neutrality, highlighting the contentious debate between market-based and public interest perspectives. In order to contextualize the debate, an overview of public utility philosophy is provided, shedding light on how the Internet can be conceptualized as a public good. Following this discussion, an analysis of mainstream media is presented, exploring how the media represents the issue of net neutrality and whether or not the Internet is discussed through the lens of public utility. To further examine how the net neutrality debate is being addressed, and to see the potential impacts of media discourses on the general public, the results of a focus group are reported and analyzed. Finally, a discussion assesses the implications of the net neutrality debate as presented through media discourses, highlighting the future of net neutrality as an important policy issue.

On implicit abstract neutral nonlinear differential equations

Energy Technology Data Exchange (ETDEWEB)

Hernández, Eduardo, E-mail: lalohm@ffclrp.usp.br [Universidade de São Paulo, Departamento de Computação e Matemática, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (Brazil); O’Regan, Donal, E-mail: donal.oregan@nuigalway.ie [National University of Ireland, School of Mathematics, Statistics and Applied Mathematics (Ireland)

2016-04-15

In this paper we continue our developments in Hernández and O’Regan (J Funct Anal 261:3457–3481, 2011) on the existence of solutions for abstract neutral differential equations. In particular we extend the results in Hernández and O’Regan (J Funct Anal 261:3457–3481, 2011) for the case of implicit nonlinear neutral equations and we focus on applications to partial “nonlinear” neutral differential equations. Some applications involving partial neutral differential equations are presented.

A Measurement of Coherent Neutral Pion Production in Neutrino Neutral Current Interactions in NOMAD experiment

CERN Document Server

Kullenberg, C T

2009-01-01

We present a study of exclusive neutral pion production in neutrino-nucleus Neutral Current interactions using data from the NOMAD experiment at the CERN SPS. The data correspond to $1.44 \\times 10^6$ muon-neutrino Charged Current interactions in the energy range $2.5 \\leq E_{\

Poly(neutral red) as a NAD{sup +} reduction catalyst and a NADH oxidation catalyst: Towards the development of a rechargeable biobattery

Energy Technology Data Exchange (ETDEWEB)

Arechederra, Marguerite N.; Addo, Paul K. [Department of Chemistry, Saint Louis University, 3501 Laclede Ave., St. Louis, MO 63103 (United States); Minteer, Shelley D., E-mail: minteers@slu.ed [Department of Chemistry, Saint Louis University, 3501 Laclede Ave., St. Louis, MO 63103 (United States)

2011-01-01

In this paper, we have established that poly(neutral red), PNR, functions as an electrocatalyst for the reduction and oxidation of NAD{sup +}/NADH in a rechargeable biobattery environment. The reversibility of this catalyst was possible only with the addition of Zn{sup 2+} for complexation to the redox polymer. The zinc ion complexation with the polymer facilitates electron and proton transfer to/from the substrate and the NAD{sup +}/NADH coenzyme without forming covalent bonds between the nicotinamide and the substrate surface. This research presents use of this reversible catalyst in a rechargeable biobattery. The rechargeable battery includes a Prussian blue cathode and a bioanode including NAD{sup +}-dependent alcohol dehydrogenase and zinc complexed PNR. This bioanode was coupled to the cathode with Nafion 212 acting as the ion exchange membrane separator between the two compartments. The biobattery has an open circuit potential of 0.545({+-}0.009) V when first assembled and 0.053({+-}0.005) V when fully discharged. However, when fully charged, the biobattery has an open circuit potential of 1.263({+-}0.051) V, a maximum power density of 16.3({+-}4.03) {mu}W cm{sup -3} and a maximum current density of 221({+-}13.2) {mu}A cm{sup -3}. The efficiency and stability of the biobattery were studied by cycling continuously at a discharging rate of 1 C and the results obtained showed reasonable stability over 50 cycles.

Design of the ITER Neutral Beam injectors

International Nuclear Information System (INIS)

Hemsworth, R.S.; Feist, J.; Hanada, M.; Heinemann, B.; Inoue, T.; Kuessel, E.; Kulygin, V.; Krylov, A.; Lotte, P.; Miyamoto, K.; Miyamoto, N.; Murdoch, D.; Nagase, A.; Ohara, Y.; Okumura, Y.; Pamela, J.; Panasenkov, A.; Shibata, K.; Tanii, M.

1996-01-01

This paper describes the Neutral Beam Injection system which is presently being designed in Europe, Japan and Russia, with co-ordination by the Joint Central Team of ITER at Naka, Japan. The proposed system consists of three negative ion based neutral injectors, delivering a total of 50 MW of 1 MeV D 0 to the ITER plasma for pulse length of ≥1000 s. The injectors each use a single caesiated volume arc discharge negative ion source, and a multi-grid, multi-aperture accelerator, to produce about 40 A of 1 MeV D - . This will be neutralized in a sub-divided gas neutralizer, which has a conversion efficiency of about 60%. The charged fraction of the beam emerging from the neutralizer is dumped in an electrostatic residual ion dump. A water cooled calorimeter can be moved into the beam path to intercept the neutral beam, allowing commissioning of the injector independent of ITER. copyright 1996 American Institute of Physics

Weak neutral-current interactions

International Nuclear Information System (INIS)

Barnett, R.M.

1978-08-01

The roles of each type of experiment in establishing uniquely the values of the the neutral-current couplings of u and d quarks are analyzed together with their implications for gauge models of the weak and electromagnetic interactions. An analysis of the neutral-current couplings of electrons and of the data based on the assumption that only one Z 0 boson exists is given. Also a model-independent analysis of parity violation experiments is discussed. 85 references

Transport of neutral atoms and molecules in TFCX

International Nuclear Information System (INIS)

Boley, C.D.

1984-09-01

The distribution of neutrals in the proposed reactor TFCX has been modeled by the 3-D Monte Carlo neutral transport code DEGAS, which has been run in conjunction with the 1-1/2-D time-dependent plasma transport code WHIST. The former code contains the best available treatment of neutral-particle physics, including a selection of wall reflection models. The latter code has a comprehensive set of plasma transport coefficients, an MHD equilibrium package, and provision for source terms such as those involving neutrals. It has a simple scrape-off model involving sound-speed flow to the neutralizer plates. The codes are run in iteration, so that the flux-surface averaged particle and energy sources due to interactions with neutrals are consistent with the plasma profiles. The design considered here has a bottom limiter with a pumping plenum. Results are given for the power balance, the mutually consistent plasma and neutral distributions set up in the edge region, the neutral density in the plenum, and the charge-exchange power deposition and erosion along the limiter

Divergence at neutral and non-neutral loci in Drosophila buzzatii populations and their hybrids

DEFF Research Database (Denmark)

Andersen, Ditte Holm; Pertoldi, Cino; Loeschcke, Volker

2008-01-01

The impact of intraspecific hybridisation on fitness and morphological traits depends on the history of natural selection and genetic drift, which may have led to differently coadapted gene-complexes in the parental populations. The divergence at neutral and non-neutral loci between populations can...... populations of Drosophila buzzatii, one between populations from Argentina and the Canary Islands (separated for 200 years), and the other between populations from Argentina and Australia (separated for 80 years). We observed the highest divergence at neutral loci between the Argentinean and Canary Island...

Intense ion beam neutralization using underdense background plasma

Energy Technology Data Exchange (ETDEWEB)

Berdanier, William [Department of Physics, The University of Texas at Austin, Austin, Texas 78712 (United States); Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543 (United States); Roy, Prabir K. [Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Kaganovich, Igor [Princeton Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543 (United States)

2015-01-15

Producing an overdense background plasma for neutralization purposes with a density that is high compared to the beam density is not always experimentally possible. We show that even an underdense background plasma with a small relative density can achieve high neutralization of intense ion beam pulses. Using particle-in-cell simulations, we show that if the total plasma electron charge is not sufficient to neutralize the beam charge, electron emitters are necessary for effective neutralization but are not needed if the plasma volume is so large that the total available charge in the electrons exceeds that of the ion beam. Several regimes of possible underdense/tenuous neutralization plasma densities are investigated with and without electron emitters or dense plasma at periphery regions, including the case of electron emitters without plasma, which does not effectively neutralize the beam. Over 95% neutralization is achieved for even very underdense background plasma with plasma density 1/15th the beam density. We compare results of particle-in-cell simulations with an analytic model of neutralization and find close agreement with the particle-in-cell simulations. Further, we show experimental data from the National Drift Compression experiment-II group that verifies the result that underdense plasma can neutralize intense heavy ion beams effectively.

Money neutrality: Rethinking the myth

Directory of Open Access Journals (Sweden)

Issaoui Fakhri

2015-01-01

Full Text Available Considered as an axiomatic basis of classical, neoclassical, and monetarist theories, the long-run money neutrality assumption does not always seem to be verified. Indeed, in our view, the money, in the sense of M2, can constitute a long-run channel of growth transmission. Thus, this paper examines the long-term relationship among money supply (M2, income (GDP, and prices (CPI. The subprime crisis in 2007 has shown that the demand for money does not only meet motives of transaction, precaution, and speculation but also of fictional or quasi-fictional future demands due to the fact that they are created without real counterparts. The capacity of production systems in developed countries to respond to increases in money supply by creating more wealth, involves the assumption of money neutrality in the long-run. However, in developing countries, the excess of money supply may lead to inflation trends. The present study has confirmed the long-term non-neutrality of money supply in the USA, and its neutrality in Gabon and Morocco.

Controllability Problem of Fractional Neutral Systems: A Survey

Directory of Open Access Journals (Sweden)

Artur Babiarz

2017-01-01

Full Text Available The following article presents recent results of controllability problem of dynamical systems in infinite-dimensional space. Generally speaking, we describe selected controllability problems of fractional order systems, including approximate controllability of fractional impulsive partial neutral integrodifferential inclusions with infinite delay in Hilbert spaces, controllability of nonlinear neutral fractional impulsive differential inclusions in Banach space, controllability for a class of fractional neutral integrodifferential equations with unbounded delay, controllability of neutral fractional functional equations with impulses and infinite delay, and controllability for a class of fractional order neutral evolution control systems.

Search for active-sterile neutrino mixing using neutral-current interactions in NOvA

Science.gov (United States)

Adamson, P.; Aliaga, L.; Ambrose, D.; Anfimov, N.; Antoshkin, A.; Arrieta-Diaz, E.; Augsten, K.; Aurisano, A.; Backhouse, C.; Baird, M.; Bambah, B. A.; Bays, K.; Behera, B.; Bending, S.; Bernstein, R.; Bhatnagar, V.; Bhuyan, B.; Bian, J.; Blackburn, T.; Bolshakova, A.; Bromberg, C.; Brown, J.; Brunetti, G.; Buchanan, N.; Butkevich, A.; Bychkov, V.; Campbell, M.; Catano-Mur, E.; Childress, S.; Choudhary, B. C.; Chowdhury, B.; Coan, T. E.; Coelho, J. A. B.; Colo, M.; Cooper, J.; Corwin, L.; Cremonesi, L.; Cronin-Hennessy, D.; Davies, G. S.; Davies, J. P.; Derwent, P. F.; Dharmapalan, R.; Ding, P.; Djurcic, Z.; Dukes, E. C.; Duyang, H.; Edayath, S.; Ehrlich, R.; Feldman, G. J.; Frank, M. J.; Gabrielyan, M.; Gallagher, H. R.; Germani, S.; Ghosh, T.; Giri, A.; Gomes, R. A.; Goodman, M. C.; Grichine, V.; Groh, M.; Group, R.; Grover, D.; Guo, B.; Habig, A.; Hartnell, J.; Hatcher, R.; Hatzikoutelis, A.; Heller, K.; Himmel, A.; Holin, A.; Howard, B.; Hylen, J.; Jediny, F.; Judah, M.; Kafka, G. K.; Kalra, D.; Kasahara, S. M. S.; Kasetti, S.; Keloth, R.; Kolupaeva, L.; Kotelnikov, S.; Kourbanis, I.; Kreymer, A.; Kumar, A.; Kurbanov, S.; Lackey, T.; Lang, K.; Lee, W. M.; Lin, S.; Lokajicek, M.; Lozier, J.; Luchuk, S.; Maan, K.; Magill, S.; Mann, W. A.; Marshak, M. L.; Matera, K.; Matveev, V.; Méndez, D. P.; Messier, M. D.; Meyer, H.; Miao, T.; Miller, W. H.; Mishra, S. R.; Mohanta, R.; Moren, A.; Mualem, L.; Muether, M.; Mufson, S.; Murphy, R.; Musser, J.; Nelson, J. K.; Nichol, R.; Niner, E.; Norman, A.; Nosek, T.; Oksuzian, Y.; Olshevskiy, A.; Olson, T.; Paley, J.; Patterson, R. B.; Pawloski, G.; Pershey, D.; Petrova, O.; Petti, R.; Phan-Budd, S.; Plunkett, R. K.; Poling, R.; Potukuchi, B.; Principato, C.; Psihas, F.; Radovic, A.; Rameika, R. A.; Rebel, B.; Reed, B.; Rocco, D.; Rojas, P.; Ryabov, V.; Sachdev, K.; Sail, P.; Samoylov, O.; Sanchez, M. C.; Schroeter, R.; Sepulveda-Quiroz, J.; Shanahan, P.; Sheshukov, A.; Singh, J.; Singh, J.; Singh, P.; Singh, V.; Smolik, J.; Solomey, N.; Song, E.; Sousa, A.; Soustruznik, K.; Strait, M.; Suter, L.; Talaga, R. L.; Tas, P.; Thayyullathil, R. B.; Thomas, J.; Tian, X.; Tognini, S. C.; Tripathi, J.; Tsaris, A.; Urheim, J.; Vahle, P.; Vasel, J.; Vinton, L.; Vold, A.; Vrba, T.; Wang, B.; Wetstein, M.; Whittington, D.; Wojcicki, S. G.; Wolcott, J.; Yadav, N.; Yang, S.; Zalesak, J.; Zamorano, B.; Zwaska, R.; NOvA Collaboration

2017-10-01

We report results from the first search for sterile neutrinos mixing with active neutrinos through a reduction in the rate of neutral-current interactions over a baseline of 810 km between the NOvA detectors. Analyzing a 14-kton detector equivalent exposure of 6.05 ×1020 protons-on-target in the NuMI beam at Fermilab, we observe 95 neutral-current candidates at the Far Detector compared with 83.5 ±9.7 (stat ) ±9.4 (syst ) events predicted assuming mixing only occurs between active neutrino species. No evidence for νμ→νs transitions is found. Interpreting these results within a 3 +1 model, we place constraints on the mixing angles θ24<20.8 ° and θ34<31.2 ° at the 90% C.L. for 0.05 eV2≤Δ m412≤0.5 eV2 , the range of mass splittings that produce no significant oscillations over the Near Detector baseline.

Method to Minimize the Low-Frequency Neutral-Point Voltage Oscillations With Time-Offset Injection for Neutral-Point-Clamped Inverters

DEFF Research Database (Denmark)

Choi, Ui-Min; Blaabjerg, Frede; Lee, Kyo-Beum

2015-01-01

time of small- and medium-voltage vectors. However, if the power factor is lower, there is a limitation to eliminate neutral-point oscillations. In this case, the proposed method can be improved by changing the switching sequence properly. Additionally, a method for neutral-point voltage balancing......This paper proposes a method to reduce the low-frequency neutral-point voltage oscillations. The neutral-point voltage oscillations are considerably reduced by adding a time offset to the three-phase turn-on times. The proper time offset is simply calculated considering the phase currents and dwell...

Detección de Anticuerpos IgG Específicos para Sarampión mediante la Técnica de Inmunofluorescencia Indirecta

Directory of Open Access Journals (Sweden)

Mónica Nieto Z

2000-01-01

Full Text Available La técnica de ínmunofluorescencia indirecta para detectar anticuerpos IgG específicos a sarampión (IFI-IgG fue evaluada con la prueba de neutralización por reducción de placas (PRN con 128 muestras de suero de personas con edades entre 0 y 15 años, 64 con antecedente de vacunación y 64 sin éste antecedente. El IFI-IgG alcanzó una sensibilidad de 80,4% y una especificidad de 100,0%, mostrando ser una prueba sencilla, reproducible, y tener correlación con PRN, aunque menos sensible que ésta última, especialmente cuando la PRN estimó títulos bajos de anticuerpos. Se concluye que la técnica IFI-IgG puede ser usada como método de rutina para la confirmación de sarampión en muestras de fase aguda y convalesciente de la enfermedad (sueros pareados, así como para estudios de prevalencia de anticuerpos en la comunidad, aunque no reemplazaría a la PRN.

Neutrality in mediation: an ambiguous ethical value

OpenAIRE

Bailey, Paul

2014-01-01

Mediator neutrality would appear, by definition, to be a necessary and required ethical principle for all mediators to practice. But what is meant by neutrality in mediation? Is it practically possible to be completely neutral between parties in mediation while at the same time being fair to both of them? This paper attempts to answer these two questions.

Neutral-beam development plan, FY 1982-1987

International Nuclear Information System (INIS)

1981-09-01

The following chapters are included: (1) status of BNL negative ion source development, (2) source development program plan, (3) status of beam transport and acceleration, (4) accelerator development program plan, (5) neutralizer concepts, (6) neutralization program plan, (7) neutral beam systems, (8) test facilities, (9) program milestones and time schedules, (10) organization and Grumman participation, and (11) funding tables

ITER neutral beam system US conceptual design

International Nuclear Information System (INIS)

Purgalis, P.

1990-09-01

In this document we present the US conceptual design of a neutral beam system for International Thermonuclear Experimental Reactor (ITER). The design incorporates a barium surface conversion D - source feeding a linear array of accelerator channels. The system uses a dc accelerator with electrostatic quadrupoles for strong focusing. A high voltage power supply that is integrated with the accelerator is presented as an attractive option. A gas neutralizer is used and residual ions exiting the neutralizer are deflected to water-cooled dumps. Cryopanels are located at the accelerator exit to pump excess gas from the source and the neutralizer, and in the ion dump cavity to pump re-neutralized ions and neutralizer gas. All the above components are packaged in compact identical, independent modules which can be removed for remote maintenance. The neutral beam system delivers 75 MW of DO at 1.3 MeV, into three ports with a total of 9 modules arranged in stacks of three modules per port . To increase reliability each module is designed to deliver up to 10 MW; this allows eight modules operating at partial capacity to deliver the required power in the event one module is out of service, and provides 20% excess capacity to improve availability. Radiation protection is provided by shielding and by locating critical components in the source and accelerator 46.5 m from the torus centerline. Neutron shielding in the drift duct and neutralizer provides the added feature of limiting conductance and thus reducing gas flow to and from the torus

Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein

International Nuclear Information System (INIS)

Zhang, Xinsheng; Wallace, Olivia L.; Domi, Arban; Wright, Kevin J.; Driscoll, Jonathan; Anzala, Omu; Sanders, Eduard J.; Kamali, Anatoli; Karita, Etienne; Allen, Susan; Fast, Pat; Gilmour, Jill; Price, Matt A.; Parks, Christopher L.

2015-01-01

Serum was analyzed from 146 healthy adult volunteers in eastern Africa to evaluate measles virus (MV) and canine distemper virus (CDV) neutralizing antibody (nAb) prevalence and potency. MV plaque reduction neutralization test (PRNT) results indicated that all sera were positive for MV nAbs. Furthermore, the 50% neutralizing dose (ND50) for the majority of sera corresponded to antibody titers induced by MV vaccination. CDV nAbs titers were low and generally were detected in sera with high MV nAb titers. A mutant CDV was generated that was less sensitive to neutralization by human serum. The mutant virus genome had 10 nucleotide substitutions, which coded for single amino acid substitutions in the fusion (F) and hemagglutinin (H) glycoproteins and two substitutions in the large polymerase (L) protein. The H substitution occurred in a conserved region involved in receptor interactions among morbilliviruses, implying that this region is a target for cross-reactive neutralizing antibodies. - Highlights: • Screened 146 serum samples for measles virus (MV) and canine distemper virus (CDV) neutralizing antibody (nAb). • MV nAb is prevalent in the sera. • CDV neutralizing activity is generally low or absent and when detected it is present in sera with high MV nAb titers. • A neutralization-resistant CDV mutant was isolated using human serum selection. • A mutation was identified in the receptor-binding region of CDV hemagglutinin protein that confers the neutralization resistance

Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein

Energy Technology Data Exchange (ETDEWEB)

Zhang, Xinsheng, E-mail: xzhang@iavi.org [AIDS Vaccine Design and Development Laboratory, International AIDS Vaccine Initiative (IAVI), Brooklyn, NY (United States); Molecular and Cellular Biology Program, State University of New York, Brooklyn, NY (United States); Wallace, Olivia L.; Domi, Arban; Wright, Kevin J.; Driscoll, Jonathan [AIDS Vaccine Design and Development Laboratory, International AIDS Vaccine Initiative (IAVI), Brooklyn, NY (United States); Anzala, Omu [Kenya AIDS Vaccine Initiative (KAVI)-Institute of Clinical Research, Nairobi (Kenya); Sanders, Eduard J. [Centre for Geographic Medicine Research, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya & Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Headington (United Kingdom); Kamali, Anatoli [MRC/UVRI Uganda Virus Research Unit on AIDS, Masaka and Entebbe (Uganda); Karita, Etienne [Projet San Francisco, Kigali (Rwanda); Allen, Susan [Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA (United States); Fast, Pat [Department of Medical Affairs, International AIDS Vaccine Initiative, NY, NY (United States); Gilmour, Jill [Human Immunology Laboratory, International AIDS Vaccine Initiative, London (United Kingdom); Price, Matt A. [Department of Medical Affairs, International AIDS Vaccine Initiative, NY, NY (United States); Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA (United States); Parks, Christopher L. [AIDS Vaccine Design and Development Laboratory, International AIDS Vaccine Initiative (IAVI), Brooklyn, NY (United States); Molecular and Cellular Biology Program, State University of New York, Brooklyn, NY (United States)

2015-08-15

Serum was analyzed from 146 healthy adult volunteers in eastern Africa to evaluate measles virus (MV) and canine distemper virus (CDV) neutralizing antibody (nAb) prevalence and potency. MV plaque reduction neutralization test (PRNT) results indicated that all sera were positive for MV nAbs. Furthermore, the 50% neutralizing dose (ND50) for the majority of sera corresponded to antibody titers induced by MV vaccination. CDV nAbs titers were low and generally were detected in sera with high MV nAb titers. A mutant CDV was generated that was less sensitive to neutralization by human serum. The mutant virus genome had 10 nucleotide substitutions, which coded for single amino acid substitutions in the fusion (F) and hemagglutinin (H) glycoproteins and two substitutions in the large polymerase (L) protein. The H substitution occurred in a conserved region involved in receptor interactions among morbilliviruses, implying that this region is a target for cross-reactive neutralizing antibodies. - Highlights: • Screened 146 serum samples for measles virus (MV) and canine distemper virus (CDV) neutralizing antibody (nAb). • MV nAb is prevalent in the sera. • CDV neutralizing activity is generally low or absent and when detected it is present in sera with high MV nAb titers. • A neutralization-resistant CDV mutant was isolated using human serum selection. • A mutation was identified in the receptor-binding region of CDV hemagglutinin protein that confers the neutralization resistance.

Active ion temperature measurement with heating neutral beam

International Nuclear Information System (INIS)

Miura, Yukitoshi; Matsuda, Toshiaki; Yamamoto, Shin

1987-03-01

When the heating neutral-beam (hydrogen beam) is injected into a deuterium plasma, the density of neutral particles is increased locally. By using this increased neutral particles, the local ion temperature is measured by the active charge-exchange method. The analyzer is the E//B type mass-separated neutral particle energy analyzer and the measured position is about one third outside of the plasma radius. The deuterium energy spectrum is Maxwellian, and the temperature is increased from 350 eV to 900 eV during heating. Since the local hydrogen to deuterium density concentration and the density of the heating neutral-beam as well as the ion temperature can be obtained good S/N ratio, the usefulness of this method during neutral-beam heating is confirmed by this experiment. (author)

Feline Immunodeficiency Virus (FIV Neutralization: A Review

Directory of Open Access Journals (Sweden)

Margaret J. Hosie

2011-10-01

Full Text Available One of the major obstacles that must be overcome in the design of effective lentiviral vaccines is the ability of lentiviruses to evolve in order to escape from neutralizing antibodies. The primary target for neutralizing antibodies is the highly variable viral envelope glycoprotein (Env, a glycoprotein that is essential for viral entry and comprises both variable and conserved regions. As a result of the complex trimeric nature of Env, there is steric hindrance of conserved epitopes required for receptor binding so that these are not accessible to antibodies. Instead, the humoral response is targeted towards decoy immunodominant epitopes on variable domains such as the third hypervariable loop (V3 of Env. For feline immunodeficiency virus (FIV, as well as the related human immunodeficiency virus-1 (HIV-1, little is known about the factors that lead to the development of broadly neutralizing antibodies. In cats infected with FIV and patients infected with HIV-1, only rarely are plasma samples found that contain antibodies capable of neutralizing isolates from other clades. In this review we examine the neutralizing response to FIV, comparing and contrasting with the response to HIV. We ask whether broadly neutralizing antibodies are induced by FIV infection and discuss the comparative value of studies of neutralizing antibodies in FIV infection for the development of more effective vaccine strategies against lentiviral infections in general, including HIV-1.

Kinetics of neutralization of Po-218

International Nuclear Information System (INIS)

Chu, K.D.

1987-01-01

In a well-defined experimental system the neutralization of polonium-218 ions was investigated as a function of the physical and chemical properties of the controlled composition atmosphere. The mobilities of Po + and PoO 2 + are determined by combining experimental results with a computer model of the system. Three neutralization mechanisms were individually studied. The small ion recombination rate has been found to be proportional to the square root of radon concentration. The electron scavenging mechanism is responsible for the neutralization of Po + in NO 2 or H 2 O in nitrogen. When PoO 2 + is formed, the electron transfer mechanism dominates the neutralization process. The electron is transferred to PoO 2 + from molecules with lower ionization potentials. The ionization potential of PoO 2 + is also determined to be 10.44 +/- 0.05 eV

Neutral and Non-Neutral Evolution of Duplicated Genes with Gene Conversion

Directory of Open Access Journals (Sweden)

Jeffrey A. Fawcett

2011-02-01

Full Text Available Gene conversion is one of the major mutational mechanisms involved in the DNA sequence evolution of duplicated genes. It contributes to create unique patters of DNA polymorphism within species and divergence between species. A typical pattern is so-called concerted evolution, in which the divergence between duplicates is maintained low for a long time because of frequent exchanges of DNA fragments. In addition, gene conversion affects the DNA evolution of duplicates in various ways especially when selection operates. Here, we review theoretical models to understand the evolution of duplicates in both neutral and non-neutral cases. We also explain how these theories contribute to interpreting real polymorphism and divergence data by using some intriguing examples.

Neutral signature Walker-VSI metrics

International Nuclear Information System (INIS)

Coley, A; McNutt, D; Musoke, N; Brooks, D; Hervik, S

2014-01-01

We will construct explicit examples of four-dimensional neutral signature Walker (but not necessarily degenerate Kundt) spaces for which all of the polynomial scalar curvature invariants vanish. We then investigate the properties of some particular subclasses of Ricci flat spaces. We also briefly describe some four-dimensional neutral signature Einstein spaces for which all of the polynomial scalar curvature invariants are constant. (paper)

Fast Neutral Pressure Measurements in NSTX

International Nuclear Information System (INIS)

R. Raman; H.W. Kugel; T. Provost; R. Gernhardt; T.R. Jarboe; M.G. Bell

2002-01-01

Several fast neutral pressure gauges have been installed on NSTX [National Spherical Torus Experiment] to measure the vessel and divertor pressure during inductive and coaxial helicity injected (CHI) plasma operations. Modified, PDX [Poloidal Divertor Experiment]-type Penning gauges have been installed on the upper and lower divertors. Neutral pressure measurements during plasma operations from these and from two shielded fast Micro ion gauges at different toroidal locations on the vessel mid-plane are described. A new unshielded ion gauge, referred to as the In-vessel Neutral Pressure (INP) gauge is under development

Enhanced neutralization potency of botulinum neurotoxin antibodies using a red blood cell-targeting fusion protein.

Directory of Open Access Journals (Sweden)

Sharad P Adekar

2011-03-01

Full Text Available Botulinum neurotoxin (BoNT potently inhibits cholinergic signaling at the neuromuscular junction. The ideal countermeasures for BoNT exposure are monoclonal antibodies or BoNT antisera, which form BoNT-containing immune complexes that are rapidly cleared from the general circulation. Clearance of opsonized toxins may involve complement receptor-mediated immunoadherence to red blood cells (RBC in primates or to platelets in rodents. Methods of enhancing immunoadherence of BoNT-specific antibodies may increase their potency in vivo. We designed a novel fusion protein (FP to link biotinylated molecules to glycophorin A (GPA on the RBC surface. The FP consists of an scFv specific for murine GPA fused to streptavidin. FP:mAb:BoNT complexes bound specifically to the RBC surface in vitro. In a mouse model of BoNT neutralization, the FP increased the potency of single and double antibody combinations in BoNT neutralization. A combination of two antibodies with the FP gave complete neutralization of 5,000 LD50 BoNT in mice. Neutralization in vivo was dependent on biotinylation of both antibodies and correlated with a reduction of plasma BoNT levels. In a post-exposure model of intoxication, FP:mAb complexes gave complete protection from a lethal BoNT/A1 dose when administered within 2 hours of toxin exposure. In a pre-exposure prophylaxis model, mice were fully protected for 72 hours following administration of the FP:mAb complex. These results demonstrate that RBC-targeted immunoadherence through the FP is a potent enhancer of BoNT neutralization by antibodies in vivo.

Edge momentum transport by neutrals: an interpretive numerical framework

Science.gov (United States)

Omotani, J. T.; Newton, S. L.; Pusztai, I.; Viezzer, E.; Fülöp, T.; The ASDEX Upgrade Team

2017-06-01

Due to their high cross-field mobility, neutrals can contribute to momentum transport even at the low relative densities found inside the separatrix and they can generate intrinsic rotation. We use a charge-exchange dominated solution to the neutral kinetic equation, coupled to neoclassical ions, to evaluate the momentum transport due to neutrals. Numerical solutions to the drift-kinetic equation allow us to cover the full range of collisionality, including the intermediate levels typical of the tokamak edge. In the edge there are several processes likely to contribute to momentum transport in addition to neutrals. Therefore, we present here an interpretive framework that can evaluate the momentum transport through neutrals based on radial plasma profiles. We demonstrate its application by analysing the neutral angular momentum flux for an L-mode discharge in the ASDEX Upgrade tokamak. The magnitudes of the angular momentum fluxes we find here due to neutrals of 0.6-2 \\text{N} \\text{m} are comparable to the net torque on the plasma from neutral beam injection, indicating the importance of neutrals for rotation in the edge.

Neutralization of wastewater from nitrite passivation

International Nuclear Information System (INIS)

Pawlowski, L.; Mientki, B.; Wasag, H.

1982-01-01

A method for neutralization of wastewater formed in nitrite passivation has been presented. The method consists of introducing urea into wastewater and acidifying it with sulphuric acid. Wastewater is neutralized with lime. After clarification, wastewater can be drained outside the plant

Effect of neutral atoms on tokamak edge plasmas

International Nuclear Information System (INIS)

Fueloep, T.; Catto, Peter J.; Helander, P.

2001-01-01

Neutral atoms can significantly influence the physics of tokamak edge plasmas, e.g., by affecting the radial electric field and plasma flow there, which may, in turn, be important for plasma confinement. Earlier work [Fueloep et al., Phys. Plasmas 5, 3969 (1998)], assuming short mean-free path neutrals and Pfirsch-Schlueter ions, has shown that the ion-neutral coupling through charge-exchange affects the neoclassical flow velocity significantly. However, the mean-free path of the neutrals is not always small in comparison with the radial scale length of densities and temperatures in the edge pedestal. It is therefore desirable to determine what happens in the limit when the neutral mean-free path is comparable with the scale length. In the present work a self-similar solution for the neutral distribution function allowing for strong temperature and density variation is used, following the analysis of Helander and Krasheninnikov [Phys. Plasmas 3, 226 (1995)]. The self-similar solution is possible if the ratio of the mean-free path to the temperature and density scale length is constant throughout the edge plasma. The resulting neutral distribution function is used to investigate the neutral effects on the ion flow and electrostatic potential as this ratio varies from much less than one to order unity

The value of Network Neutrality for the Internet of Tomorrow : Report of the Dynamic Coalition on Network Neutrality

OpenAIRE

Belli , Luca; De Filippi , Primavera

2013-01-01

The report explores some of the most crucial facets of Network Neutrality, underscoring its close relationship with the full enjoyment of end-users fundamental rights. The report also includes a proposal for a Model Framework on Network Neutrality that has been elaborated by the Dynamic Coalition through an open, inclusive and multi-stakeholder effort, in order to promote an efficient safeguard of the Net Neutrality principle in accordance with international human rights standards.

Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers.

Science.gov (United States)

Birse, Kenzie D M; Cole, Amy L; Hirbod, Taha; McKinnon, Lyle; Ball, Terry B; Westmacott, Garrett R; Kimani, Joshua; Plummer, Frank; Cole, Alexander M; Burgener, Adam; Broliden, Kristina

2015-01-01

Cationic proteins found in cervicovaginal secretions (CVS) are known to contribute to the early antiviral immune response against HIV-infection in vitro. We here aimed to define additional antiviral factors that are over-expressed in CVS from female sex workers at high risk of infection. CVS were collected from Kenyan HIV-seronegative (n = 34) and HIV-seropositive (n = 12) female sex workers, and were compared with those from HIV-seronegative low-risk women (n = 12). The highly exposed seronegative (HESN) sex workers were further divided into those with less (n = 22) or more (n = 12) than three years of documented sex work. Cationic protein-depleted CVS were assessed for HIV-neutralizing activity by a PBMC-based HIV-neutralizing assay, and then characterized by proteomics. HIV neutralizing activity was detected in all unprocessed CVS, however only CVS from the female sex worker groups maintained its HIV neutralizing activity after cationic protein-depletion. Differentially abundant proteins were identified in the cationic protein-depleted secretions including 26, 42, and 11 in the HESN>3 yr, HESNHIV-positive groups, respectively. Gene ontology placed these proteins into functional categories including proteolysis, oxidation-reduction, and epidermal development. The proteins identified in this study include proteins previously associated with the HESN phenotype in other cohorts as well as novel proteins not yet associated with anti-HIV activities. While cationic proteins appear to contribute to the majority of the intrinsic HIV neutralizing activity in the CVS of low-risk women, a broader range of non-cationic proteins were associated with HIV neutralizing activity in HESN and HIV-positive female sex workers. These results indicate that novel protein factors found in CVS of women with high-risk sexual practices may have inherent antiviral activity, or are involved in other aspects of anti-HIV host defense, and warrant further exploration into their mode of action.

Recent DIII-D neutral beam calibration results

International Nuclear Information System (INIS)

Wight, J.; Hong, R.M.; Phillips, J.

1991-10-01

Injected DIII-D neutral beam power is estimated based on three principle quantities: the fraction of ion beam that is neutralized in the neutralizer gas cell, the beamline transmission efficiency, and the fraction of beam reionized in the drift duct. System changes in the past few years have included a new gradient grid voltage operating point, ion source arc regulation, routine deuterium operations and new neutralizer gas flow controllers. Additionally, beam diagnostics have been improved and better calibrated. To properly characterize the beams the principle quantities have been re-measured. Two diagnostics are primarily used to measure the quantities. The beamline waterflow calorimetry system measures the neutralization efficiency and the beamline transmission efficiency, and the target tile thermocouples measure the reionization loss. An additional diagnostic, the target tile pyrometer, confirmed the reionization loss measurement. Descriptions and results of these measurements will be presented. 4 refs., 5 figs., 2 tabs

Dual modifications strategy to quantify neutral and sialylated N-glycans simultaneously by MALDI-MS.

Science.gov (United States)

Zhou, Hui; Warren, Peter G; Froehlich, John W; Lee, Richard S

2014-07-01

Differences in ionization efficiency among neutral and sialylated glycans prevent direct quantitative comparison by their respective mass spectrometric signals. To overcome this challenge, we developed an integrated chemical strategy, Dual Reactions for Analytical Glycomics (DRAG), to quantitatively compare neutral and sialylated glycans simultaneously by MALDI-MS. Initially, two glycan samples to be compared undergo reductive amination with 2-aminobenzoic acid and 2-(13)[C6]-aminobenzoic acid, respectively. The different isotope-incorporated glycans are then combined and subjected to the methylamidation of the sialic acid residues in one mixture, homogenizing the ionization responses for all neutral and sialylated glycans. By this approach, the expression change of relevant glycans between two samples is proportional to the ratios of doublet signals with a static 6 Da mass difference in MALDI-MS and the change in relative abundance of any glycan within samples can also be determined. The strategy was chemically validated using well-characterized N-glycans from bovine fetuin and IgG from human serum. By comparing the N-glycomes from a first morning (AM) versus an afternoon (PM) urine sample obtained from a single donor, we further demonstrated the ability of DRAG strategy to measure subtle quantitative differences in numerous urinary N-glycans.

Resistance to changing practice from pro re nata prescriptions to patient group directions in acute mental health settings.

Science.gov (United States)

Price, O; Baker, J A

2013-09-01

Poor practice associated with pro re nata (PRN) prescriptions in mental health is known to be common and can increase the risk of serious and potentially fatal side effects. A contributing factor to poor practice is the lack of a clear chain of accountability between the decision to prescribe and administer PRN prescriptions. To address this problem, a patient group direction (PGD) for acute behavioural disturbance (lorazepam 0.5-2 mg) and staff training materials were developed. The intention was to replace PRN prescriptions with the PGD in two mental health trusts. One of the potential benefits of this would be the removal of the contribution of PRN to high and combined dose antipsychotic prescriptions. This proposal, however, was met with significant resistance in both trusts and did not replace PRN as a result. A series of interviews and focus groups were conducted with 16 RMNs working in the two trusts, to explore the reasons why the PGD was met with resistance. Senior nurses perceived resistance to be associated with anxieties over increased responsibility for decision making. Junior nurses reported concerns regarding the medicalization of the nursing role, the paperwork associated with the PGD and the training approach used. Future efforts to implement PGDs in mental health settings must carefully consider the methods for engaging effectively with participating organizations, in terms of managing change and completing the necessary groundwork for successful implementation. © 2012 John Wiley & Sons Ltd.

Post-infection immunodeficiency virus control by neutralizing antibodies.

Directory of Open Access Journals (Sweden)

Hiroyuki Yamamoto

Full Text Available BACKGROUND: Unlike most acute viral infections controlled with the appearance of virus-specific neutralizing antibodies (NAbs, primary HIV infections are not met with such potent and early antibody responses. This brings into question if or how the presence of potent antibodies can contribute to primary HIV control, but protective efficacies of antiviral antibodies in primary HIV infections have remained elusive; and, it has been speculated that even NAb induction could have only a limited suppressive effect on primary HIV replication once infection is established. Here, in an attempt to answer this question, we examined the effect of passive NAb immunization post-infection on primary viral replication in a macaque AIDS model. METHODS AND FINDINGS: The inoculums for passive immunization with simian immunodeficiency virus mac239 (SIVmac239-specific neutralizing activity were prepared by purifying polyclonal immunoglobulin G from pooled plasma of six SIVmac239-infected rhesus macaques with NAb induction in the chronic phase. Passive immunization of rhesus macaques with the NAbs at day 7 after SIVmac239 challenge resulted in significant reduction of set-point plasma viral loads and preservation of central memory CD4 T lymphocyte counts, despite the limited detection period of the administered NAb responses. Peripheral lymph node dendritic cell (DC-associated viral RNA loads showed a remarkable peak with the NAb administration, and DCs stimulated in vitro with NAb-preincubated SIV activated virus-specific CD4 T lymphocytes in an Fc-dependent manner, implying antibody-mediated virion uptake by DCs and enhanced T cell priming. CONCLUSIONS: Our results present evidence indicating that potent antibody induction post-infection can result in primary immunodeficiency virus control and suggest direct and indirect contribution of its absence to initial control failure in HIV infections. Although difficulty in achieving requisite neutralizing titers for

Negative ion based neutral beams for plasma heating

International Nuclear Information System (INIS)

Prelec, K.

1978-01-01

Neutral beam systems based on negative ions have been considered because of a high expected power efficiency. Methods for the production, acceleration and neutralization of negative ions will be reviewed and possibilities for an application in neutral beam lines explored

Density peaking in the JFT-2M tokamak plasma with counter neutral beam injection

International Nuclear Information System (INIS)

Ida, K.; Itoh, S.; Itoh, K.

1991-05-01

A significant particle pinch and reduction of the effective thermal diffusivity are observed after switching the neutral beam direction from co- to counter- injection in the JFT-2M tokamak. A time delay in the occurrence of density peaking to that of plasma rotation is found. This shows that the particle pinch is related to the profile of the electric field as determined by the plasma rotation profile. The measured particle flux shows qualitative agreement with the theoretically-predicted inward pinch. (author)

Targets for high power neutral beams

International Nuclear Information System (INIS)

Kim, J.

1980-01-01

Stopping high-power, long-pulse beams is fast becoming an engineering challenge, particularly in neutral beam injectors for heating magnetically confined plasmas. A brief review of neutral beam target technology is presented along with heat transfer calculations for some selected target designs

Neutralizing antibodies against two HIV-1 strains in consecutively collected serum samples: cross neutralization and association to HIV-1 related disease

DEFF Research Database (Denmark)

Arendrup, M; Nielsen, C M; Hansen, J E

1992-01-01

97 sera collected during a 10-year period from 10 HIV-1 infected individuals were tested for neutralizing capacity against a virus isolate FICPH-22 obtained from a Danish AIDS patient, and the laboratory strain HTLV-IIIB. Three patterns of serum neutralizing activity were demonstrated: (a) patients...... developing high neutralizing activity against both HIV strains; (b) patients developing high neutralizing activity against the Danish virus isolate; and (c) patients developing only low titers of neutralizing antibodies (NA) against both HIV strains. The HTLV-IIIB strain was less sensitive to serum...... neutralization than the FICPH-22 isolate and the appearance of NA against HTLV-IIIB was typically lacking several years behind that against FICPH-22 indicating a broadening of the NA response over time. No difference in clinical outcome was observed comparing patients reaching high titers of NA and patients...

Improved numerical calculation of the generation of a neutral beam by charge transfer between chlorine ions/neutrals and a graphite surface

International Nuclear Information System (INIS)

Kubota, Tomohiro; Samukawa, Seiji; Watanabe, Naoki; Ohtsuka, Shingo; Iwasaki, Takuya; Ono, Kohei; Iriye, Yasuroh

2014-01-01

The charge transfer process between chlorine particles (ions or neutrals) and a graphite surface on collision was investigated by using a highly stable numerical simulator based on time-dependent density functional theory to understand the generation mechanism of a high-efficiency neutral beam developed by Samukawa et al (2001 Japan. J. Appl. Phys. 40 L779). A straightforward calculation was achieved by adopting a large enough unit cell. The dependence of the neutralization efficiency on the incident energy of the particle was investigated, and the trend of the experimental result was reproduced. It was also found that doping the electrons and holes into graphite could change the charge transfer process and neutralization probability. This result suggests that it is possible to develop a neutral beam source that has high neutralization efficiency for both positive and negative ions. (paper)

Mechanical design criteria for continuously operating neutral beams

International Nuclear Information System (INIS)

Vosen, S.R.; Bender, D.J.; Fink, J.H.; Lee, J.D.

1977-01-01

A schematic of a neutral beam injector is shown. Neutral gas is injected into the ion source, where a discharge ionizes the gas. The ions are drawn from the source by an extractor grid and then accelerated to full energy by the accel grids. After acceleration the ions pass through the neutralizer cell. Once through the neutralizer cell, the beam consists of neutrals and ions. The ions traveling with the beam are space charge neutralized by background electrons. The grid which precedes the direct converter is negatively charged and acts to separate the electrons from the rest of the beam. As a result of the beam's uncompensated space charge the remaining ions spread out from the beam to be collected at the direct converter. This paper presents a generalized analysis which will be useful in determining effects of energy and particle fluxes on the long-term performance of the grids

Sputtering of neutral and ionic indium clusters

International Nuclear Information System (INIS)

Ma, Z.; Coon, S.R.; Calaway, W.F.; Pellin, M.J.; Gruen, D.M.; Von Nagy-Felsobuki, E.I.

1993-01-01

Secondary neutral and secondary ion cluster yields were measured during the sputtering of a polycrystalline indium surface by normally incident ∼4 keV Ar + ions. In the secondary neutral mass spectra, indium clusters as large as In 32 were observed. In the secondary ion mass spectra, indium clusters up to In 18 + were recorded. Cluster yields obtained from both the neutral and ion channel exhibited a power law dependence on the number of constituent atoms, n, in the cluster, with the exponents measured to be -5.6 and -4. 1, respectively. An abundance drop was observed at n=8, 15, and 16 in both the neutral and ion yield distributions suggesting that the stability of the ion (either secondary ion or photoion) plays a significant role in the observed distributions. In addition, our experiments suggest that unimolecular decomposition of the neutral cluster may also plays an important role in the measured yield distributions

Inhibition of Neutral Red Photolysis with Different Antioxidants

Directory of Open Access Journals (Sweden)

Zlatan Rimpapa

2007-02-01

Full Text Available Neutral red is a dye the azine structure which has been used as an acido-base indicator and a dye in histochemistry. In 1960 Goldhaber introduced Neutral red into the medium of resorbing bone cultures to localize the osteoclast in the living cultures. Using time-lapse microcinematography in order to follow the osteoclasts, he reported excellent contrast could be obtained with Neutral red due to the avidity of osteoclasts for this dye. Unfortunately, however, the photodynamic effect resulting from subsequent exposure of these cultures to light precluded this approach, and again in 1963. it was observed that the death of the osteoclasts was probably due to a photodynamic effect related to the dye in the cell, the presence of oxygen and the frequent exposure of light by our time-lapse photography. VIS and UV irradiation induced photolysis of Neutral red, and from Neutral red cation produced with photons a Neutral red radical. This Neutral red radical can be inhibited with action of an antioxidant, such as melatonin, glutathione, ascorbic acid, E vitamin, etc. We developed an assay with Neutral redphotolysis which utilizes a VIS and UV irradiation technique for quantification the inhibition of photolysis with action of an antioxidant. In this method Neutral red acts double, as a free radical generator and as a photosensitizer.

Soviet exoatmospheric neutral particle beam research

International Nuclear Information System (INIS)

Leiss, J.E.; Abrams, R.H.; Ehlers, K.W.; Farrell, J.A.; Gillespie, G.H.; Jameson, R.A.; Keefe, D.; Parker, R.K.

1988-02-01

This technical assessment was performed by a panel of eight U.S. scientists and engineers who are familiar with Soviet research through their own research experience, their knowledge of the published scientific literature and conference proceedings, and personal contacts with Soviet scientists and other foreign colleagues. Most of the technical components of a neutral particle beam generating system including the ion source, the accelerator, the accelerator radio frequency power supply, the beam conditioning and aiming system, and the beam neutralizer system are addressed. It does not address a number of other areas important to an exoatmospheric neutral beam system

Two dimensional neutral transport analysis in tokamak plasma

International Nuclear Information System (INIS)

Shimizu, Katsuhiro; Azumi, Masafumi

1987-02-01

Neutral particle influences the particle and energy balance, and play an important role on sputtering impurity and the charge exchange loss of neutral beam injection. In order to study neutral particle behaviour including the effects of asymmetric source and divertor configuration, the two dimensional neutral transport code has been developed using the Monte-Carlo techniques. This code includes the calculation of the H α radiation intensity based on the collisional-radiation model. The particle confinement time of the joule heated plasma in JT-60 tokamak is evaluated by comparing the calculated H α radiation intensity with the experimental data. The effect of the equilibrium on the neutral density profile in high-β plasma is also investigated. (author)

Net Neutrality and Inflation of Traffic

NARCIS (Netherlands)

Peitz, M.; Schütt, F.

2015-01-01

Under strict net neutrality Internet service providers (ISPs) are required to carry data without any differentiation and at no cost to the content provider. We provide a simple framework with a monopoly ISP to evaluate different net neutrality rules. Content differs in its sensitivity to delay.

Variations in thermo-optical properties of neutral red dye with laser ablated gold nanoparticles

Science.gov (United States)

Prakash, Anitha; Pathrose, Bini P.; Mathew, S.; Nampoori, V. P. N.; Radhakrishnan, P.; Mujeeb, A.

2018-05-01

We have investigated the thermal and optical properties of neutral red dye incorporated with different weight percentage of gold nanoparticles prepared by laser ablation method. Optical absorption studies confirmed the production of spherical nanoparticles and also the interactions of the dye molecules with gold nanoparticles. The quenching of fluorescence and the reduction in the lifetime of gold incorporated samples were observed and was due to the non-radiative energy transfer between the dye molecules and gold nanoparticles. Dual beam thermal lens technique has been employed to measure the heat diffusion in neutral red with various weight percentage of gold nano sol dispersed in ethanol. The significant outcome of the experiment is that, the overall heat diffusion is slower in the presence of gold nano sol compared to that of dye alone sample. Brownian motion is suggested to be the main mechanism of heat transfer under the present conditions. The thermal diffusivity variations of samples with respect to different excitation power of laser were also studied.

Characterization of iminothiosulfine-type ions [HNCS 2] rad +/ rad - and their neutral counterparts by mass spectrometry and computational chemistry

Science.gov (United States)

Vivekananda, S.; Raghunath, P.; Bhanuprakash, K.; Srinivas, R.; Trikoupis, Moschoula A.; Terlouw, Johan K.

2000-12-01

Electron ionization of rhodanine yields iminothiosulfine ions H- N C- S- Srad + , 1brad + , which readily communicate with the higher energy cyclic isomer H- N CS2rad + , 1arad + . CBS-QB3 and G AUSSIAN-2 model chemistries predict that one electron reduction reverses the stability order but that the (singlet) neutrals remain connected via a negligible energy barrier. Neutralization-reionization (NR) experiments demonstrate that singlet 1a and its heterocumulene isomer 1b are stable species in the gas-phase. However, the co-generated triplet species readily dissociate into 3S2rad + + HNC. Confirmatory experimental evidence comes from charge reversal (CR) and NR experiments on the cyclic anion H- N CS2rad - , 1arad - .

ITER Neutral Beam Injection System

International Nuclear Information System (INIS)

Ohara, Yoshihiro; Tanaka, Shigeru; Akiba, Masato

1991-03-01

A Japanese design proposal of the ITER Neutral Beam Injection System (NBS) which is consistent with the ITER common design requirements is described. The injection system is required to deliver a neutral deuterium beam of 75MW at 1.3MeV to the reactor plasma and utilized not only for plasma heating but also for current drive and current profile control. The injection system is composed of 9 modules, each of which is designed so as to inject a 1.3MeV, 10MW neutral beam. The most important point in the design is that the injection system is based on the utilization of a cesium-seeded volume negative ion source which can produce an intense negative ion beam with high current density at a low source operating pressure. The design value of the source is based on the experimental values achieved at JAERI. The utilization of the cesium-seeded volume source is essential to the design of an efficient and compact neutral beam injection system which satisfies the ITER common design requirements. The critical components to realize this design are the 1.3MeV, 17A electrostatic accelerator and the high voltage DC acceleration power supply, whose performances must be demonstrated prior to the construction of ITER NBI system. (author)

Net neutrality and inflation of traffic

NARCIS (Netherlands)

Peitz, M.; Schütt, Florian

Under strict net neutrality Internet service providers (ISPs) are required to carry data without any differentiation and at no cost to the content provider. We provide a simple framework with a monopoly ISP to evaluate the short-run effects of different net neutrality rules. Content differs in its

Neutral currents, supernovae neutrinos, and nucleosynthesis

International Nuclear Information System (INIS)

Haxton, W.C.

1988-01-01

The inelastic interactions of neutrinos during stellar collapse and neutron star cooling are discussed. The primary mechanism for dissipative neutrino reactions is nuclear excitation by neutral current scattering, a process not included in standard descriptions of supernovae. Charge-current and neutral current ''preheating'' of iron lying outside the shock front appears to be significant in the few milliseconds near shock breakout. This could help produce a more energetic shock. During the cooling phase, the neutral current interactions of muon and taon neutrinos appear to be responsible for some interesting nucleosynthesis. I discuss two examples the production of fluorine and neutrino-induced r-process nucleosynthesis. 26 refs., 1 fig., 3 tabs

Impact of neutral density fluctuations on gas puff imaging diagnostics

Science.gov (United States)

Wersal, C.; Ricci, P.

2017-11-01

A three-dimensional turbulence simulation of the SOL and edge regions of a toroidally limited tokamak is carried out. The simulation couples self-consistently the drift-reduced two-fluid Braginskii equations to a kinetic equation for neutral atoms. A diagnostic neutral gas puff on the low-field side midplane is included and the impact of neutral density fluctuations on D_α light emission investigated. We find that neutral density fluctuations affect the D_α emission. In particular, at a radial distance from the gas puff smaller than the neutral mean free path, neutral density fluctuations are anti-correlated with plasma density, electron temperature, and D_α fluctuations. It follows that the neutral fluctuations reduce the D_α emission in most of the observed region and, therefore, have to be taken into account when interpreting the amplitude of the D_α emission. On the other hand, higher order statistical moments (skewness, kurtosis) and turbulence characteristics (such as correlation length, or the autocorrelation time) are not significantly affected by the neutral fluctuations. At distances from the gas puff larger than the neutral mean free path, a non-local shadowing effect influences the neutral density fluctuations. There, the D_α fluctuations are correlated with the neutral density fluctuations, and the high-order statistical moments and measurements of other turbulence properties are strongly affected by the neutral density fluctuations.

32 CFR 644.323 - Neutral language.

Science.gov (United States)

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Neutral language. 644.323 Section 644.323 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal § 644.323 Neutral language. Wherever the words “man”, “men”, or their related...

Toxicity of binary chemical munition destruction products: methylphosphonic acid, methylphosphinic acid, 2-diisopropylaminoethanol, DF neutralent, and QL neutralent.

Science.gov (United States)

Watson, Rebecca E; Hafez, Ahmed M; Kremsky, Jonathan N; Bizzigotti, George O

2007-01-01

This paper reports the toxicity and environmental impact of neutralents produced from the hydrolysis of binary chemical agent precursor chemicals DF (methylphosphonic difluoride) and QL (2-[bis(1-methylethyl)amino]ethyl ethyl methylphosphonite). Following a literature review of the neutralent mixtures and constituents, basic toxicity tests were conducted to fill data gaps, including acute oral and dermal median lethal dose assays, the Ames mutagenicity test, and ecotoxicity tests. For methylphosphonic acid (MPA), a major constituent of DF neutralent, the acute oral LD(50) in the Sprague-Dawley rat was measured at 1888 mg/kg, and the Ames test using typical tester strains of Salmonella typhimurium and Escherichia coli was negative. The 48-h LC(50) values for pH-adjusted DF neutralent with Daphnia magna and Cyprinodon variegatus were > 2500 mg/L and 1593 mg/L, respectively. The acute oral LD(50) values in the rat for QL neutralent constituents methylphosphinic acid (MP) and 2-diisopropylaminoethanol (KB) were both determined to be 940 mg/kg, and the Ames test was negative for both. Good Laboratory Practice (GLP)-compliant ecotoxicity tests for MP and KB gave 48-h D. magna EC(50) values of 6.8 mg/L and 83 mg/L, respectively. GLP-compliant 96-h C. variegatus assays on MP and KB gave LC(50) values of 73 and 252 mg/L, respectively, and NOEC values of 22 and 108 mg/L. QL neutralent LD(50) values for acute oral and dermal toxicity tests were both > 5000 mg/kg, and the 48-h LD(50) values for D. magna and C. variegatus were 249 and 2500 mg/L, respectively. Using these data, the overall toxicity of the neutralents was assessed.

Ontario's Poverty Reduction Strategy: A Critical Discourse Analysis.

Science.gov (United States)

Benbow, Sarah; Gorlick, Carolyne; Forchuk, Cheryl; Ward-Griffin, Catherine; Berman, Helene

2016-01-01

This article overviews the second phase of a two-phase study which examined experiences of health and social exclusion among mothers experiencing homelessness in Ontario, Canada. A critical discourse analysis was employed to analyze the policy document, Realizing Our Potential: Ontario's Poverty Reduction Strategy, 2014-2019. In nursing, analysis of policy is an emerging form of scholarship, one that draws attention to the macro levels influencing health and health promotion, such as the social determinants of health, and the policies that impact them. The clear neo-liberal underpinnings, within the strategy, with a focus on productivity and labor market participation leave little room for an understanding of poverty reduction from a human rights perspective. Further, gender-neutrality rendered the poverty experienced by women, and mothers, invisible. Notably, there were a lack of deadlines, target dates, and thorough action and evaluation plans. Such absence troubles whether poverty reduction is truly a priority for the government, and society as a whole.

Serbia's Military Neutrality: Origins, effects and challenges

Directory of Open Access Journals (Sweden)

Ejdus Filip

2014-10-01

Full Text Available Serbia is the only state in the Western Balkans that is not seeking NATO membership. In December 2007, Serbia declared military neutrality and in spite of its EU membership aspirations, developed very close relations with Moscow. The objective of this paper is threefold. First, I argue that in order to understand why Serbia declared military neutrality, one has to look both at the discursive terrain and domestic power struggles. The key narrative that was strategically used by mnemonic entrepreneurs, most importantly by the former Prime Minister Vojislav Koštunica, to legitimize military neutrality was the trauma of NATO intervention in 1999 and the ensuing secession of Kosovo. In the second part of the paper, I discuss the operational consequences of the military neutrality policy for Serbia's relations with NATO and Russia, as well as for military reform and EU accession. Finally, I spell out the challenges ahead in Serbia's neutrality policy and argue that its decision makers will increasingly be caught between pragmatic foreign policy requirements on the one hand and deeply entrenched traumatic memories on the other.

Corrosion protection method by neutral treatment for boilers

International Nuclear Information System (INIS)

Ishikawa, Hisashige

1978-01-01

The corrosion protection method by neutral treatment has been applied in Europe mainly for boilers and nuclear reactors instead of existing all volatile treatment. The cause of corrosion of steel and copper in water and the effect of neutral treatment, that is the effect of protection film of magnetite in steel and cuprous oxide in copper alloy, are explained with the characteristic figure of PH, electromotive force and chemical formula. The experience of applying this neutral treatment to the Wedel thermal power plant and the system flow sheet, the water treatment equipment, relating instrumentations and the water examination are described in detail. Hydrogen peroxide is injected in this neutral treatment. The comparison between the existing water treatment and the neutral treatment and their merits and demerits are explained. (Nakai, Y.)

The Myth of Neutral Judge: Overcoming Neutrality by the Cognition Theory And the Pursuit of Legal Certainty

Directory of Open Access Journals (Sweden)

Alyane Almeida de Araújo

2016-11-01

Full Text Available The  Law  scientific-rational  character  created  the  image  of  a  neutral  judge;  however, Neuroscience currently shows that the decision-making process involves activations in the prefrontal cortex along with emotions management areas. The aim of this work is to check the subsistence of the neutral judge after the cognition theory, with points of reflexion in post- positivist hermeneutics. Using the comprehensive method on bibliographic prospection, we conclude that despite the neutrality has been overcome, the search for legal certainty continues, which will be achieved through values and social purposes of the onwn normative system.

Current profile redistribution driven by neutral beam injection in a reversed-field pinch

Energy Technology Data Exchange (ETDEWEB)

Parke, E. [Department of Physics and Astronomy, University of California Los Angeles 475 Portola Plaza, Los Angeles, California 90095 (United States); Department of Physics, University of Wisconsin-Madison 1150 University Ave., Madison, Wisconsin 53706 (United States); Anderson, J. K.; Den Hartog, D. J. [Department of Physics, University of Wisconsin-Madison 1150 University Ave., Madison, Wisconsin 53706 (United States); Brower, D. L.; Ding, W. X.; Lin, L. [Department of Physics and Astronomy, University of California Los Angeles 475 Portola Plaza, Los Angeles, California 90095 (United States); Johnson, C. A. [Department of Physics, University of Wisconsin-Madison 1150 University Ave., Madison, Wisconsin 53706 (United States); Department of Physics, Auburn University 206 Allison Laboratory, Auburn, Alabama 36849 (United States)

2016-05-15

Neutral beam injection in reversed-field pinch (RFP) plasmas on the Madison Symmetric Torus [Dexter et al., Fusion Sci. Technol. 19, 131 (1991)] drives current redistribution with increased on-axis current density but negligible net current drive. Internal fluctuations correlated with tearing modes are observed on multiple diagnostics; the behavior of tearing mode correlated structures is consistent with flattening of the safety factor profile. The first application of a parametrized model for island flattening to temperature fluctuations in an RFP allows inferrence of rational surface locations for multiple tearing modes. The m = 1, n = 6 mode is observed to shift inward by 1.1 ± 0.6 cm with neutral beam injection. Tearing mode rational surface measurements provide a strong constraint for equilibrium reconstruction, with an estimated reduction of q{sub 0} by 5% and an increase in on-axis current density of 8% ± 5%. The inferred on-axis current drive is consistent with estimates of fast ion density using TRANSP [Goldston et al., J. Comput. Phys. 43, 61 (1981)].

Neutral beam development plan

International Nuclear Information System (INIS)

Staten, H.S.

1980-08-01

The national plan is presented for developing advanced injection systems for use on upgrades of existing experiments, and use on future facilities such as ETF, to be built in the late 1980's or early 90's where power production from magnetic fusion will move closer to a reality. Not only must higher power and longer pulse length systems be developed , but they must operate reliably; they must be a tool for the experimenter, not the experiment itself. Neutral beam systems handle large amounts of energy and as such, they often are as complicated as the plasma physics experiment itself. This presents a significant challenge to the neutral beam developer

Photoproduction of neutral pions off protons

NARCIS (Netherlands)

Crede, V.; Sparks, N.; Wilson, A.; Anisovich, A. V.; Bacelar, J. C. S.; Bantes, R.; Bartholomy, O.; Bayadilov, D.; Beck, R.; Beloglazov, Y. A.; Castelijns, R.; Dutz, H.; Elsner, D.; Ewald, R.; Frommberger, F.; Funke, Chr; Gregor, R.; Gridnev, A.; Gutz, E.; Hillert, W.; Hoffmeister, P.; Jaegle, I.; Junkersfeld, J.; Kalinowsky, H.; Kammer, S.; Klein, Frank; Klein, Friedrich; Klempt, E.; Kotulla, M.; Krusche, B.; Löhner, H.; Lopatin, I. V.; Lugert, S.; Menze, D.; Mertens, T.; Messchendorp, J. G.; Metag, V.; Nanova, M.; Nikonov, V. A.; Novinski, D.; Novotny, R.; Ostrick, M.; Pant, L. M.; van Pee, H.; Pfeiffer, M.; Roy, A.; Sarantsev, A. V.; Schadmand, S.; Schmidt, C.; Schmieden, H.; Schoch, B.; Shende, S.; Sokhoyan, V.; Suele, A.; Sumachev, V. V.; Szczepanek, T.; Thoma, U.; Trnka, D.; Varma, R.; Walther, D.; Wendel, Ch

2011-01-01

Photoproduction of neutral pions has been studied with the CBELSA/TAPS detector in the reaction gamma p -> p pi(0) for photon energies between 0.85 and 2.50 GeV. The pi(0) mesons are observed in their dominant neutral decay mode: pi(0) -> gamma gamma. For the first time, the differential cross

Gender Neutrality: Women's Friend or Foe?

Science.gov (United States)

Steuernagel, Trudy

Gender neutral public policies are those that are either silent on the question of the existence of significant gender differences or incorporate a perspective which mandates that such differences be ignored. Prominent voices today contend that gender neutrality favors males and have held the male standard as the one for which women should aspire.…

A safe and reliable neutralization assay based on pseudovirus to measure neutralizing antibody titer against poliovirus.

Science.gov (United States)

Liu, Shaohua; Song, Dongmei; Bai, Han; Lu, Weiwei; Dai, Xinxian; Hao, Chunsheng; Zhang, Zhongyang; Guo, Huijie; Zhang, Yue; Li, Xiuling

2017-12-01

With the promotion of inactivated poliomyelitis vaccine (IPV) and live attenuated oral poliomyelitis vaccine (OPV), the global reported cases of poliomyelitis have reduced sharply from 0.35 million in 1988 to 74 in 2015. The Polio Eradication & Endgame Strategic Plan published by WHO in 2013 included the strategy of implementation of poliovirus safe handling and containment measures to minimize the risks of facility-associated reintroduction of virus into the polio-free community to prevent the re-import of poliovirus. Toward this strategy, we produced replication-incompetent pseudovirus of poliovirus type 1, 2, 3 attenuated strains by constructing poliovirus capsid expression vectors and poliovirus replicon then transfecting HEK293T cells and developed a pseudovirus-based neutralization assay (pNA) to determine neutralizing antibody titer which is more secure, time-saving and reliable than conventional neutralization assay (cNA). By using anti-poliovirus rat serum, we demonstrated excellent correlation between neutralizing antibody titers measured by cNA and pNA. It was concluded that pNA can be a potential alternative to replace cNA as a safe and time-saving system for titer determination after live poliovirus's safekeeping. © 2017 Wiley Periodicals, Inc.

ICAN: High power neutral beam generation

International Nuclear Information System (INIS)

Moustaizis, S.D.; Lalousis, P.; Perrakis, K.; Auvray, P.; Larour, J.; Ducret, J.E.; Balcou, P.

2015-01-01

During the last few years there is an increasing interest on the development of alternative high power new negative ion source for Tokamak applications. The proposed new neutral beam device presents a number of advantages with respect to: the density current, the acceleration voltage, the relative compact dimension of the negative ion source, and the coupling of a high power laser beam for photo-neutralization of the negative ion beam. Here we numerically investigate, using a multi- fluid 1-D code, the acceleration and the extraction of high power ion beam from a Magnetically Insulated Diode (MID). The diode configuration will be coupled to a high power device capable of extracting a current up to a few kA with an accelerating voltage up to MeV. An efficiency of up to 92% of the coupling of the laser beam, is required in order to obtain a high power, up to GW, neutral beam. The new high energy, high average power, high efficiency (up to 30%) ICAN fiber laser is proposed for both the plasma generation and the photo-neutralizer configuration. (authors)

Are Moral Disengagement, Neutralization Techniques, and Self-Serving Cognitive Distortions the Same? Developing a Unified Scale of Moral Neutralization of Aggression

Directory of Open Access Journals (Sweden)

Denis Ribeaud

2010-12-01

Full Text Available

Negative ion formation and neutralization processes, (2)

International Nuclear Information System (INIS)

Sugiura, Toshio

1982-09-01

This review is 2nd part of the report published at January 1982 (JAERI-M-9902). A compilation includes the survey of the data of the cross sections of H - and D - ion formations and the neutralization of these ions. This is also presented new information about the photosensitization by laser beam in dissociative-resonance electron capture of sulfur hexafluoride reported by Chen et al., for reference to enhancement of D - ions in discharge. For neutralization, the data of mutual neutralization and photodetachment are also presented. (author)

The neural fate of neutral information in emotion-enhanced memory.

Science.gov (United States)

Watts, Sarah; Buratto, Luciano G; Brotherhood, Emilie V; Barnacle, Gemma E; Schaefer, Alexandre

2014-07-01

In this study, we report evidence that neural activity reflecting the encoding of emotionally neutral information in memory is reduced when neutral and emotional stimuli are intermixed during encoding. Specifically, participants studied emotional and neutral pictures organized in mixed lists (in which emotional and neutral pictures were intermixed) or in pure lists (only-neutral or only-emotional pictures) and performed a recall test. To estimate encoding efficiency, we used the Dm effect, measured with event-related potentials. Recall for neutral items was lower in mixed compared to pure lists and posterior Dm activity for neutral items was reduced in mixed lists, whereas it remained robust in pure lists. These findings might be caused by an asymmetrical competition for attentional and working memory resources between emotional and neutral information, which could be a major determinant of emotional memory effects. Copyright © 2014 Society for Psychophysiological Research.

Neutral axis as damage sensitive feature

International Nuclear Information System (INIS)

Sigurdardottir, D H; Glisic, B

2013-01-01

Structural health monitoring (SHM) is the process of continuously or periodically measuring structural parameters and the transformation of the collected data into information on real structural conditions. The centroid of stiffness is a universal parameter and its position in a cross-section can be evaluated for any load-carrying beam structure as the position of the neutral axis under conveniently chosen loads. Thus, a change in the position of the neutral axis within a cross-section can indicate a change in the position of the centroid of stiffness, i.e., unusual structural behaviors. This paper proposes a novel monitoring method based on deterministic and probabilistic determination of the position of the neutral axis under conveniently chosen conditions. Therefore, the method proposed in this paper is potentially applicable to a large variety of beam-like structures. Data from two existing structures were used to validate the method and assess its performance: Streicker Bridge at Princeton University and the US202/NJ23 highway overpass in Wayne, NJ. The results show that the neutral axis location is varying even when damage is not present. Reasons for this variation are determined and the accuracy in the evaluation assessed. This paper concludes that the position of the neutral axis can be evaluated with sufficient accuracy using static and dynamic strain measurements performed on appropriate time-scales and indicates its potential to be used as a damage sensitive feature. (paper)

Neutral axis as damage sensitive feature

Science.gov (United States)

Sigurdardottir, D. H.; Glisic, B.

2013-07-01

Structural health monitoring (SHM) is the process of continuously or periodically measuring structural parameters and the transformation of the collected data into information on real structural conditions. The centroid of stiffness is a universal parameter and its position in a cross-section can be evaluated for any load-carrying beam structure as the position of the neutral axis under conveniently chosen loads. Thus, a change in the position of the neutral axis within a cross-section can indicate a change in the position of the centroid of stiffness, i.e., unusual structural behaviors. This paper proposes a novel monitoring method based on deterministic and probabilistic determination of the position of the neutral axis under conveniently chosen conditions. Therefore, the method proposed in this paper is potentially applicable to a large variety of beam-like structures. Data from two existing structures were used to validate the method and assess its performance: Streicker Bridge at Princeton University and the US202/NJ23 highway overpass in Wayne, NJ. The results show that the neutral axis location is varying even when damage is not present. Reasons for this variation are determined and the accuracy in the evaluation assessed. This paper concludes that the position of the neutral axis can be evaluated with sufficient accuracy using static and dynamic strain measurements performed on appropriate time-scales and indicates its potential to be used as a damage sensitive feature.

Evolutionary advantage via common action of recombination and neutrality

Science.gov (United States)

Saakian, David B.; Hu, Chin-Kun

2013-11-01

We investigate evolution models with recombination and neutrality. We consider the Crow-Kimura (parallel) mutation-selection model with the neutral fitness landscape, in which there is a central peak with high fitness A, and some of 1-point mutants have the same high fitness A, while the fitness of other sequences is 0. We find that the effect of recombination and neutrality depends on the concrete version of both neutrality and recombination. We consider three versions of neutrality: (a) all the nearest neighbor sequences of the peak sequence have the same high fitness A; (b) all the l-point mutations in a piece of genome of length l≥1 are neutral; (c) the neutral sequences are randomly distributed among the nearest neighbors of the peak sequences. We also consider three versions of recombination: (I) the simple horizontal gene transfer (HGT) of one nucleotide; (II) the exchange of a piece of genome of length l, HGT-l; (III) two-point crossover recombination (2CR). For the case of (a), the 2CR gives a rather strong contribution to the mean fitness, much stronger than that of HGT for a large genome length L. For the random distribution of neutral sequences there is a critical degree of neutrality νc, and for μmutations affect the mean-field-like and fluctuation-like factors similarly. Consequently, recombination can accelerate the non-mean-field (fluctuation) type dynamics without considerably affecting the mean-field-like factors.

Heavy-atom neutral beams for tandem-mirror end plugs

International Nuclear Information System (INIS)

Post, D.E.; Grisham, L.R.; Santarius, J.F.; Emmert, G.A.

1981-05-01

The advantages of neutral beams with Z greater than or equal to 3 formed from negative ions, accelerated to 0.5 to 1.0 MeV/amu, and neutralized with high efficiency, are investigated for use in tandem mirror reactor end plugs. These beams can produce Q's of 20 to 30, and thus can replace the currently proposed 200 to 500 keV neutral proton beams presently planned for tandem mirror reactors. Thus, these Z greater than or equal to 3 neutral beams increase the potential attractiveness of tandem mirror reactors by offering a substitute for difficult high energy neutral hydrogen end plug beams

Monte Carlo neutral density calculations for ELMO Bumpy Torus

International Nuclear Information System (INIS)

Davis, W.A.; Colchin, R.J.

1986-11-01

The steady-state nature of the ELMO Bumpy Torus (EBT) plasma implies that the neutral density at any point inside the plasma volume will determine the local particle confinement time. This paper describes a Monte Carlo calculation of three-dimensional atomic and molecular neutral density profiles in EBT. The calculation has been done using various models for neutral source points, for launching schemes, for plasma profiles, and for plasma densities and temperatures. Calculated results are compared with experimental observations - principally spectroscopic measurements - both for guidance in normalization and for overall consistency checks. Implications of the predicted neutral profiles for the fast-ion-decay measurement of neutral densities are also addressed

Neutral beams for magnetic fusion

International Nuclear Information System (INIS)

Hooper, B.

1977-01-01

Significant advances in forming energetic beams of neutral hydrogen and deuterium atoms have led to a breakthrough in magnetic fusion: neutral beams are now heating plasmas to thermonuclear temperatures, here at LLL and at other laboratories. For example, in our 2XIIB experiment we have injected a 500-A-equivalent current of neutral deuterium atoms at an average energy of 18 keV, producing a dense plasma (10 14 particles/cm 3 ) at thermonuclear energy (14 keV or 160 million kelvins). Currently, LLL and LBL are developing beam energies in the 80- to 120-keV range for our upcoming MFTF experiment, for the TFTR tokamak experiment at Princeton, and for the Doublet III tokamak experiment at General Atomic. These results increase our long-range prospects of producing high-intensity beams of energies in the hundreds or even thousands of kilo-electron-volts, providing us with optimistic extrapolations for realizing power-producing fusion reactors

Charge neutralization of small ion beam clumps

Energy Technology Data Exchange (ETDEWEB)

Welch, D R [Mission Research Corp., Albuquerque, NM (United States); Olson, C L; Hanson, D L [Sandia National Labs., Albuquerque, NM (United States)

1997-12-31

The mega-ampere currents associated with light ion fusion (LIF) require excellent charge neutralization to prevent divergence growth. As the size and space-charge potential of a beam clump or `beamlet` become small (submillimeter size and kilovolt potentials), the neutralization becomes increasingly difficult. Linear theory predicts that plasma electrons cannot neutralize potentials < {phi}{sub crit} = (1/2)m{sub e}v{sub i}{sup 2}/e, where m{sub e} is the electron mass and v{sub i} is the ion beam velocity. A non-uniform beam would, therefore, have regions with potentials sufficient to add divergence to beam clumps. The neutralization of small beamlets produced on the SABLE accelerator and in numerical simulation has supported the theory, showing a plateau in divergence growths as the potential in the beamlet exceeds {phi}{sub crit}. (author). 1 tab., 2 figs., 4 refs.

Measurement of plasma production and neutralization in gas neutralizers

International Nuclear Information System (INIS)

Maor, D.; Meron, M.; Johnson, B.; Jones, K.; Agagu, A.; Hu, B.

1986-01-01

In order to satisfy the need of experimental data for the designing of gas neutralizers we have started a project aimed at measuring all relevant cross sections for the charge exchange of H - , H 0 and H + projectiles, as well as the cross sections for the production of ions in the target. The expected results of these latter measurements are shown schematically

Evaluation of smallpox vaccines using variola neutralization.

Science.gov (United States)

Damon, Inger K; Davidson, Whitni B; Hughes, Christine M; Olson, Victoria A; Smith, Scott K; Holman, Robert C; Frey, Sharon E; Newman, Frances; Belshe, Robert B; Yan, Lihan; Karem, Kevin

2009-08-01

The search for a 'third'-generation smallpox vaccine has resulted in the development and characterization of several vaccine candidates. A significant barrier to acceptance is the absence of challenge models showing induction of correlates of protective immunity against variola virus. In this light, virus neutralization provides one of few experimental methods to show specific 'in vitro' activity of vaccines against variola virus. Here, we provide characterization of the ability of a modified vaccinia virus Ankara vaccine to induce variola virus-neutralizing antibodies, and we provide comparison with the neutralization elicited by standard Dryvax vaccination.

Output power characteristics of the neutral xenon long laser

Energy Technology Data Exchange (ETDEWEB)

Linford, G.J. [TRW Space and Electronics Group, Redondo Beach, CA (United States). Space and Technology Div.

1994-12-31

Lasers which oscillate within inhomogeneously broadened gain media exhibit spectral hole burning and concomitant reduction in output power compared with equivalent homogeneously-broadened laser gain media. By increasing the cavity length, it may be possible to demonstrate at least a partial transition from an inhomogeneous laser cavity mode spectrum to a homogeneous spectrum. There are a number of high gain laser lines which are inhomogeneously-broadened transitions in electric discharges of neutral xenon. In neutral xenon lasers, as in the cases of many other gas lasers, the inhomogeneous spectral broadening mechanism arises from Doppler shifts, {Delta}{nu}{sub D}, of individual atoms in thermal motion within the electric discharge comprising the laser gain medium. Optical transitions corresponding to these noble gas atoms have natural linewidths, {Delta}{nu}{sub n}{lt}{Delta}{nu}{sub D}. Simulations of the output power characteristics of the xenon laser were carried out as a function of laser cavity parameters, including the cavity length, L. These calculations showed that when the intracavity mode spacing frequency, c/2L{lt}{Delta}{nu}{sub n}, the inhomogeneously broadened xenon mode spectrum converted to a homogeneously broadened oscillation spectrum with an increase in output power. These simulations are compared with experimental results obtained for the long laser oscillation characteristics of the (5d[5/2]{degree}{sub 2}{r_arrow}6p[3/2]{sub 1}) transition corresponding to the strong, high-gain 3.508 {mu} line in xenon.

Transition from positive to neutral in mutation fixation along with continuing rising fitness in thermal adaptive evolution.

Science.gov (United States)

Kishimoto, Toshihiko; Iijima, Leo; Tatsumi, Makoto; Ono, Naoaki; Oyake, Ayana; Hashimoto, Tomomi; Matsuo, Moe; Okubo, Masato; Suzuki, Shingo; Mori, Kotaro; Kashiwagi, Akiko; Furusawa, Chikara; Ying, Bei-Wen; Yomo, Tetsuya

2010-10-21

It remains to be determined experimentally whether increasing fitness is related to positive selection, while stationary fitness is related to neutral evolution. Long-term laboratory evolution in Escherichia coli was performed under conditions of thermal stress under defined laboratory conditions. The complete cell growth data showed common continuous fitness recovery to every 2°C or 4°C stepwise temperature upshift, finally resulting in an evolved E. coli strain with an improved upper temperature limit as high as 45.9°C after 523 days of serial transfer, equivalent to 7,560 generations, in minimal medium. Two-phase fitness dynamics, a rapid growth recovery phase followed by a gradual increasing growth phase, was clearly observed at diverse temperatures throughout the entire evolutionary process. Whole-genome sequence analysis revealed the transition from positive to neutral in mutation fixation, accompanied with a considerable escalation of spontaneous substitution rate in the late fitness recovery phase. It suggested that continually increasing fitness not always resulted in the reduction of genetic diversity due to the sequential takeovers by fit mutants, but caused the accumulation of a considerable number of mutations that facilitated the neutral evolution.

The innovation-enhancing effects of network neutrality

NARCIS (Netherlands)

Kocsis, V.; Weda, J.

2013-01-01

In the past decade, economists, legal experts, and policy makers have been discussing the effects of neutral network structures on - among others - innovations by content and application providers. Does network neutrality - the open and non-discriminatory functioning of the internet - provide

The Framing of Network Neutrality Governance

DEFF Research Database (Denmark)

Perry, James

The neutrality of the internet with regard to applications (e.g. search, social networking, email, to mention only three) has been central to innovation and growth in the knowledge-economy over the past two decades. Until recently, neutrality was built into the internet's design via its core stan...... with a critical analysis of their respective operational paradigms, the paper seeks to understand who is framing the debate, how they are doing so, and to what (systemic) effect....... generative: Useful innovations in applications of the internet could take hold easily, and it was difficult – or indeed impossible - for incumbent business interests to disrupt or sabotage them. However, this neutrality is now under threat. New technologies have given incumbent businesses the ability...

Current neutralization of converging ion beams

International Nuclear Information System (INIS)

Mosher, D.

1978-01-01

It is desired to consider the problem of current neutralization of heavy ion beams traversing gas backgrounds in which the conductivity changes due to beam heating and beam convergence. The procedure is to determine Green's-function solutions to the magnetic-diffusion equation derived from Maxwell's equations and an assumed scaler-plasma conductivity sigma for the background-electron current density j/sub e/. The present calculation is more general than some previously carried out in that arbitrary time variations for the beam current j/sub b/ and conductivity are allowed and the calculation is valid for both weak and strong neutralization. Results presented here must be combined with an appropriate energy-balance equation for the heated background in order to obtain the neutralization self-consistently

Truly neutral microobjects and oscillations in particle physics

International Nuclear Information System (INIS)

Bilenky, S.M.; Pontecorvo, B.

1982-01-01

Oscillation phenomena between different states of neutral elementary particles are discussed. The known kaon oscillation and the proposed neutrino, neutron and other kinds of oscillations are analysed. The proper bound states of neutral objects (neutrinos, neutrons, hydrogen atoms) are investigated in the case of small and strong violation of CP symmetry. Consequences concerning the observable masses and quantum numbers of such neutral objects are drawn. (D.Gy.)

Neutral currents in semileptonic reactions

International Nuclear Information System (INIS)

Paschos, E.A.

1975-05-01

The evidence for weak neutral currents is analyzed in semileptonic reactions with special emphasis on their Lorentz and internal symmetry structure. It is found that present observations are consistent with the expectations of gauge theories, but other possibilities can not be ruled out. Of particular interest in this respect is the presence of a large isoscalar component. The excitation of the Δ-resonance by neutral currents is analyzed, and pion-nucleon mass distributions are presented. Charge asymmetries sensitive to isoscalar-isovector interferences are discussed. (U.S.)

Long-Run Neutrality and Superneutrality in an ARIMA Framework.

OpenAIRE

Fisher, Mark E; Seater, John J

1993-01-01

The authors formalize long-run neutrality and long-run superneutrality in the context of a bivariate ARIMA model; show how the restrictions implied by long-run neutrality and long-run superneutrality depend on the orders of integration of the variables; apply their analysis to previous work, showing how that work is related to long-run neutrality and long-run superneutrality; and provide some new evidence on long-run neutrality and long-run superneutrality. Copyright 1993 by American Economic...

Research on Stress Neutral Layer Offset in the Straightening Process

Directory of Open Access Journals (Sweden)

Hailian Gui

2015-01-01

Full Text Available The stress neutral layer offset is analyzed by theoretical and numerical calculation methods. In traditional straightening theory, the stress neutral layer was consistent with the geometric central layer. However, there is a phenomenon that the stress neutral layer has some offset with the geometric neutral layer. This offset is a very important factor for improving the precision of the straightening force. The formula of the stress neutral layer offset is obtained by a theoretical method and the change law is given by numerical calculation method. The neutral layer offset theory provides the theoretical basis for establishing the model of straightening force precisely.

A General Nonlinear Fluid Model for Reacting Plasma-Neutral Mixtures

Energy Technology Data Exchange (ETDEWEB)

Meier, E T; Shumlak, U

2012-04-06

A generalized, computationally tractable fluid model for capturing the effects of neutral particles in plasmas is derived. The model derivation begins with Boltzmann equations for singly charged ions, electrons, and a single neutral species. Electron-impact ionization, radiative recombination, and resonant charge exchange reactions are included. Moments of the reaction collision terms are detailed. Moments of the Boltzmann equations for electron, ion, and neutral species are combined to yield a two-component plasma-neutral fluid model. Separate density, momentum, and energy equations, each including reaction transfer terms, are produced for the plasma and neutral equations. The required closures for the plasma-neutral model are discussed.

Electrochemical Reduction of Zinc Phosphate

International Nuclear Information System (INIS)

Kim, Chang Hwan; Lee, Jung Hyun; Shin, Woon Sup

2010-01-01

We demonstrated first that the electrochemical reduction of zinc phosphate in neutral phosphate buffer is possible and potentially applicable to bio-compatible rechargeable battery. The actual redox component is Zn(s)/Zn phosphate(s) and the future research about the control of crystal formation for the better cyclability is required. In lead-acid battery, the electrochemical redox reaction of Pb (s) /PbSO 4(s) is used by reducing Pb(II) and oxidizing Pb(0) in sulfate rich solution. Since both reduced form and oxidized form are insoluble, they cannot diffuse to the opposite electrodes and react. It is a very common strategy to make a stable battery electrode that a metal element is reduced and oxidized in solution containing an abundance of anion readily precipitating with the metal ion. For the application of this strategy to construction of rechargeable battery using bio-compatible electrode materials and electrolytes, the use of phosphate ion can be considered as anion readily precipitating with metal ions. If phosphate buffer with neutral pH is used as electrolyte, the better bio-compatibility will be achieved than most of rechargeable battery using strong acid, strong base or organic solvent as electrolyte solution. There are many metal ions readily precipitating with phos-phate ion, and zinc is one of them

Auditors' Professional Skepticism: Neutrality versus Presumptive Doubt

NARCIS (Netherlands)

Groot, T.L.C.M.; Quadackers, L.M.; Wright, A.

2014-01-01

Although skepticism is widely viewed as essential to audit quality, there is a debate about what form is optimal. The two prevailing perspectives that have surfaced are "neutrality" and "presumptive doubt." With neutrality, auditors neither believe nor disbelieve client management. With presumptive

Neutral theory of chemical reaction networks

International Nuclear Information System (INIS)

Lee, Sang Hoon; Holme, Petter; Minnhagen, Petter; Bernhardsson, Sebastian; Kim, Beom Jun

2012-01-01

To what extent do the characteristic features of a chemical reaction network reflect its purpose and function? In general, one argues that correlations between specific features and specific functions are key to understanding a complex structure. However, specific features may sometimes be neutral and uncorrelated with any system-specific purpose, function or causal chain. Such neutral features are caused by chance and randomness. Here we compare two classes of chemical networks: one that has been subjected to biological evolution (the chemical reaction network of metabolism in living cells) and one that has not (the atmospheric planetary chemical reaction networks). Their degree distributions are shown to share the very same neutral system-independent features. The shape of the broad distributions is to a large extent controlled by a single parameter, the network size. From this perspective, there is little difference between atmospheric and metabolic networks; they are just different sizes of the same random assembling network. In other words, the shape of the degree distribution is a neutral characteristic feature and has no functional or evolutionary implications in itself; it is not a matter of life and death. (paper)

Efficient Means of Detecting Neutral Atoms in Space

Science.gov (United States)

Zinicola, W. N.

2006-12-01

This summer, The Society of Physics Students granted me the opportunity to participate in an internship for The National Aeronautics and Space Administration (NASA) and The University of Maryland. Our chief interest was analyzing low energy neutral atoms that were created from random interactions of ions in space plasma. From detecting these neutrals one can project a image of what the plasma's composition is, and how this plasma changes through interactions with the solar wind. Presently, low energy neutral atom detectors have poor efficiency, typically in the range of 1%. Our goal was to increase this efficiency. To detect low energy neutrals we must first convert them from neutral molecules to negatively charged ions. Once converted, these "new" negatively charged ions can be easily detected and completely analyzed giving us information about their energy, mass, and instantaneous direction. The efficiency of the detector is drastically affected by the surface used for converting these neutrals. My job was first to create thin metal conversion surfaces. Then, using an X-ray photoelectron spectrometer, analyze atomic surface composition and gather work function values. Once the work function values were known we placed the surfaces in our neutral detector and measured their conversion efficiencies. Finally, a relation between the work function of the metal surface an its conversion efficiency was generated. With this relationship accurately measured one could use this information to help give suggestions on what surface would be the best to increase our detection efficiency. If we could increase the efficiency of these low energy neutral atom detectors by even 1% we would be able to decrease the size of the detector therefore making it cheaper and more applicable for space exploration.* * A special thanks to Dr. Michael Coplan of the University of Maryland for his support and guidance through all my research.

Detection of extensive cross-neutralization between pandemic and seasonal A/H1N1 Influenza Viruses using a pseudotype neutralization assay.

Directory of Open Access Journals (Sweden)

Béatrice Labrosse

Full Text Available BACKGROUND: Cross-immunity between seasonal and pandemic A/H1N1 influenza viruses remains uncertain. In particular, the extent that previous infection or vaccination by seasonal A/H1N1 viruses can elicit protective immunity against pandemic A/H1N1 is unclear. METHODOLOGY/PRINCIPAL FINDINGS: Neutralizing titers against seasonal A/H1N1 (A/Brisbane/59/2007 and against pandemic A/H1N1 (A/California/04/2009 were measured using an HIV-1-based pseudovirus neutralization assay. Using this highly sensitive assay, we found that a large fraction of subjects who had never been exposed to pandemic A/H1N1 express high levels of pandemic A/H1N1 neutralizing titers. A significant correlation was seen between neutralization of pandemic A/H1N1 and neutralization of a standard seasonal A/H1N1 strain. Significantly higher pandemic A/H1N1 neutralizing titers were measured in subjects who had received vaccination against seasonal influenza in 2008-2009. Higher pandemic neutralizing titers were also measured in subjects over 60 years of age. CONCLUSIONS/SIGNIFICANCE: Our findings reveal that the extent of protective cross-immunity between seasonal and pandemic A/H1N1 influenza viruses may be more important than previously estimated. This cross-immunity could provide a possible explanation of the relatively mild profile of the recent influenza pandemic.

46 CFR 120.376 - Grounded distribution systems (Neutral grounded).

Science.gov (United States)

2010-10-01

....376 Section 120.376 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS... distribution system having a neutral bus or conductor must have the neutral grounded. (c) The neutral or each...

Rare decays of neutral π and eta

International Nuclear Information System (INIS)

Poutissou, J.M.

1983-09-01

The decays of the pseudoscalar neutral mesons π degree and eta degree have provided a test of fundamental principles. The main branch, π degree → 2γ, was investigated in the late 60's in the context of current algebra and the decay rate calculated from the singular triangle diagram is in excellent agreement with experiment. Rare leptonic decays of the neutral pseudoscalar mesons are of interest because of the information they reveal about neutral currents or other exotic interactions between leptons and quarks. The author discusses recent information on the π degree → e + e - decay

46 CFR 183.376 - Grounded distribution systems (neutral grounded).

Science.gov (United States)

2010-10-01

....376 Section 183.376 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER... propulsion, power, lighting, or distribution system having a neutral bus or conductor must have the neutral... generator to ground before the generator is connected to the bus, except the neutral of an emergency power...

Analysis of variola and vaccinia virus neutralization assays for smallpox vaccines.

Science.gov (United States)

Hughes, Christine M; Newman, Frances K; Davidson, Whitni B; Olson, Victoria A; Smith, Scott K; Holman, Robert C; Yan, Lihan; Frey, Sharon E; Belshe, Robert B; Karem, Kevin L; Damon, Inger K

2012-07-01

Possible smallpox reemergence drives research for third-generation vaccines that effectively neutralize variola virus. A comparison of neutralization assays using different substrates, variola and vaccinia (Dryvax and modified vaccinia Ankara [MVA]), showed significantly different 90% neutralization titers; Dryvax underestimated while MVA overestimated variola neutralization. Third-generation vaccines may rely upon neutralization as a correlate of protection.

Development of KSTAR Neutral Beam Heating System

Energy Technology Data Exchange (ETDEWEB)

Oh, B. H.; Song, W. S.; Yoon, B. J. (and others)

2007-10-15

The prototype components of a neutral beam injection (NBI) system have been developed for the KSTAR, and a capability of the manufactured components has been tested. High power ion source, acceleration power supply, other ion source power supplies, neutralizer, bending magnet for ion beam separation, calorimeter, and cryo-sorption pump have been developed by using the domestic technologies and tested for a neutral beam injection of 8 MW per beamline with a pulse duration of 300 seconds. The developed components have been continuously upgraded to achieve the design requirements. The development technology of high power and long pulse neutral beam injection system has been proved with the achievement of 5.2 MW output for a short pulse length and 1.6 MW output for a pulse length of 300 seconds. Using these development technologies, the domestic NB technology has been stabilized under the development of high power ion source, NB beamline components, high voltage and current power supplies, NB diagnostics, NB system operation and control.

International Thermonuclear Experimental Reactor (ITER) neutral beam design

International Nuclear Information System (INIS)

Myers, T.J.; Brook, J.W.; Spampinato, P.T.; Mueller, J.P.; Luzzi, T.E.; Sedgley, D.W.

1990-10-01

This report discusses the following topics on ITER neutral beam design: ion dump; neutralizer and module gas flow analysis; vacuum system; cryogenic system; maintainability; power distribution; and system cost

(IAM Series No 005) Are “Market Neutral” Hedge Funds Really Market Neutral?

OpenAIRE

Andrew Patton

2004-01-01

One can consider the concept of market neutrality for hedge funds as having breadth and depth: breadth reflects the number of market risks to which a fund is neutral, while depth reflects the completeness of the neutrality of the fund to market risks. We focus on market neutrality depth, and propose five different neutrality concepts. Mean neutrality nests the standard correlation-based definition of neutrality. Variance neutrality, Value-at-Risk neutrality and tail neutrality all relate to t...

Switching from pro re nata to treat-and-extend regimen improves visual acuity in patients with neovascular age-related macular degeneration.

Science.gov (United States)

Kvannli, Line; Krohn, Jørgen

2017-11-01

To evaluate the visual outcome after transitioning from a pro re nata (PRN) intravitreal injection regimen to a treat-and-extend (TAE) regimen for patients with neovascular age-related macular degeneration (AMD). A retrospective review of patients who were switched from a PRN regimen with intravitreal injections of bevacizumab, ranibizumab or aflibercept to a TAE regimen. The best corrected visual acuity (BCVA), central retinal thickness (CRT) and type of medication used at baseline, at the time of changing treatment regimen and at the end of the study were analysed. Twenty-one eyes of 21 patients met the inclusion criteria. Prior to the switch, the patients received a mean of 13.8 injections (median, 10; range, 3-39 injections) with the PRN regimen for 44 months (range, 3-100 months), which improved the visual acuity in five patients (24%). After a mean of 6.1 injections (median, 5; range, 3-14 injections) with the TAE regimen over 8 months (range, 2-16 months), the visual acuity improved in 12 patients (57%). The improvement in visual acuity during treatment with the TAE regimen was statistically significant (p = 0.005). The proportion of patients with a visual acuity of 0.2 or better was significantly higher after treatment with the TAE regimen than after treatment with the PRN regimen (p = 0.048). No significant differences in CRT were found between the two treatment regimens. Even after prolonged treatment and a high number of intravitreal injections, switching AMD patients from a PRN regimen to a strict TAE regimen significantly improves visual acuity. © 2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Steady state neutral beam injector

International Nuclear Information System (INIS)

Mattoo, S.K.; Bandyopadhyay, M.; Baruah, U.K.; Bisai, N.; Chakbraborty, A.K.; Chakrapani, Ch.; Jana, M.R.; Bajpai, M.; Jaykumar, P.K.; Patel, D.; Patel, G.; Patel, P.J.; Prahlad, V.; Rao, N.V.M.; Rotti, C.; Singh, N.P.; Sridhar, B.

2000-01-01

Learning from operational reliability of neutral beam injectors in particular and various heating schemes including RF in general on TFTR, JET, JT-60, it has become clear that neutral beam injectors may find a greater role assigned to them for maintaining the plasma in steady state devices under construction. Many technological solutions, integrated in the present day generation of injectors have given rise to capability of producing multimegawatt power at many tens of kV. They have already operated for integrated time >10 5 S without deterioration in the performance. However, a new generation of injectors for steady state devices have to address to some basic issues. They stem from material erosion under particle bombardment, heat transfer > 10 MW/m 2 , frequent regeneration of cryopanels, inertial power supplies, data acquisition and control of large volume of data. Some of these engineering issues have been addressed to in the proposed neutral beam injector for SST-1 at our institute; the remaining shall have to wait for the inputs of the database generated from the actual experience with steady state injectors. (author)

Γ-source Neutral Point Clamped Inverter

DEFF Research Database (Denmark)

Mo, Wei; Loh, Poh Chiang; Blaabjerg, Frede

Transformer based Z-source inverters are recently proposed to achieve promising buck-boost capability. They have improved higher buck-boost capability, smaller size and less components count over Z-source inverters. On the other hand, neutral point clamped inverters have less switching stress...... and better output performance comparing with traditional two-level inverters. Integrating these two types of configurations can help neutral point inverters achieve enhanced votlage buck-boost capability....

Operation of a TFTR ion source with a ground potential gas feed into the neutralizer

International Nuclear Information System (INIS)

Kamperschroer, J.H.; Dudek, L.E.; Grisham, L.R.; Newman, R.A.; O'Connor, T.E.; Stevenson, T.N.; von Halle, A.; Williams, M.D.; Wright, K.E.

1991-01-01

TFTR long pulse ion sources have been operated with gas fed only into the neutralizer. Gas for the plasma generator entered through the accelerator rather than directly into the arc chamber. This modification has been proposed for tritium beam operation to locate control electronics at ground potential and to simplify tritium plumbing. Source operation with this configuration and with the nominal gas system that feeds gas into both the ion source and the center of the neutralizer are compared. Comparison is based upon accelerator grid currents, beam composition, and neutral power delivered to the calorimeter. Charge exchange in the accelerator can be a significant loss mechanism in both systems at high throughput. A suitable operating point with the proposed system was found that requires 30% less gas than used presently. The extracted D + , D + 2 , and D + 3 fractions of the beam were found to be a function of the gas throughput; at similar throughputs, the two gas feed systems produced similar extracted ion fractions. Operation at the proposed gas efficient point results in a small reduction (relative to the old high throughput mode) in the extracted D + fraction of the beam from 77% to 71%, with concomitant changes in the D + 2 fraction from 18% to 26%, and 6% to 3% for D + 3 . The injected power is unchanged, ∼2.2 MW at 95 kV

Plasma heating with multi-MeV neutral atom beams

International Nuclear Information System (INIS)

Grisham, L.R.; Post, D.E.; Mikkelsen, D.R.; Eubank, H.P.

1981-10-01

We explore the utility and feasibility of neutral beams of greater than or equal to 6 AMU formed from negative ions, and also of D 0 formed from D - . The negative ions would be accelerated to approx. 1 to 2 MeV/AMU and neutralized, whereupon the neutral atoms would be used to heat and, perhaps, to drive current in magnetically confined plasmas. Such beams appear feasible and offer the promise of significant advantages relative to conventional neutral beams based on positive deuterium ions at approx. 150 keV

Net neutrality towards a co-regulatory solution

CERN Document Server

Marsden, Christopher T

2010-01-01

In considering market developments and policy responses to some of the most heated net-neutrality debates in Europe and the United States, Net Neutrality is the first, fully comprehensive overview of the subject. This book is also unique in providing readers with a supplementary outline of recommended policy prescriptives.

Energy spectrum of neutrals formed in an ion accelerator

International Nuclear Information System (INIS)

Fink, J.H.

1982-01-01

This work presents an estimate of the energy distribution of the neutrals formed in the ion beam accelerator. However it does not determine the fraction of those neutrals which leave the neutral beam injector and go on into the reactor. To do that, more details of the beam line performance are needed

Method to minimize the low-frequency neutral-point voltage oscillations with time-offset injection for neutral-point-clamped inverters

DEFF Research Database (Denmark)

Choi, Uimin; Lee, Kyo-Beum; Blaabjerg, Frede

2013-01-01

This paper proposes a method to reduce the low-frequency neutral-point voltage oscillations. The neutral-point voltage oscillations are considerably reduced by adding a time-offset to the three phase turn-on times. The proper time-offset is simply calculated considering the phase currents and dwell...

Coupled plasma-neutral transport model for the scrape-off region

International Nuclear Information System (INIS)

Galambos, J.D.; Peng, Y.K.M.; Heifetz, D.

1985-03-01

Analysis of the scrape-off region requires treatment of the plasma transport along and across the field lines and inclusion of the neutral transport effects. A method for modeling the scrape-off region that is presented here uses separate models for each of these aspects that are coupled together through an iteration procedure that requires only minimal numerical effort. The method is applied here to estimate the neutral pumping rates in the pump-limiter and divertor options for a proposed deuterium-tritium (D-T) ignition experiment. High neutral recycling in the vicinity of the neutralizer plate dramatically affects pumping rates for both the pump-limiter and divertor. In both cases, the plasma flow into the channel surrounding the neutralizer plate is greatly reduced by the neutral recycling. The fraction of this flow that is pumped can be large (> 50%), but in general it is dependent on the particular geometry and plasma conditions. It is estimated that pumping speeds approximately greater than 10 5 L/s are adequate for the exhaust requirements in the pump-limiter and the divertor cases. Also, high neutral recycling on the front surface of the limiter tends to increase the neutral pumping rate

Economic Features of the Internet and Network Neutrality

OpenAIRE

Nicholas Economides

2015-01-01

We discuss the issue of a possible abolition of network neutrality and the introduction of paid prioritization by residential broadband access networks.We show that, in short run analysis where bandwidth is fixed, and in the absence of congestion, network neutrality tends to maximize total surplus. When an ISP violates network neutrality and invests the extra profits to bandwidth expansion, the presence of more bandwidth alleviates the allocative distortion, and can even reverse it. We also d...

Vendor neutral archive in PACS

International Nuclear Information System (INIS)

Agarwal, Tapesh Kumar; Sanjeev

2012-01-01

An archive is a location containing a collection of records, documents, or other materials of historical importance. An integral part of Picture Archiving and Communication System (PACS) is archiving. When a hospital needs to migrate a PACS vendor, the complete earlier data need to be migrated in the format of the newly procured PACS. It is both time and money consuming. To address this issue, the new concept of vendor neutral archive (VNA) has emerged. A VNA simply decouples the PACS and workstations at the archival layer. This is achieved by developing an application engine that receives, integrates, and transmits the data using the different syntax of a Digital Imaging and Communication in Medicine (DICOM) format. Transferring the data belonging to the old PACS to a new one is performed by a process called migration of data. In VNA, a number of different data migration techniques are available to facilitate transfer from the old PACS to the new one, the choice depending on the speed of migration and the importance of data. The techniques include simple DICOM migration, prefetch-based DICOM migration, medium migration, and the expensive non-DICOM migration. “Vendor neutral” may not be a suitable term, and “architecture neutral,” “PACS neutral,” “content neutral,” or “third-party neutral” are probably better and preferred terms. Notwithstanding this, the VNA acronym has come to stay in both the medical IT user terminology and in vendor nomenclature, and radiologists need to be aware of its impact in PACS across the globe

Material failures observed in Doublet III neutral beamlines

International Nuclear Information System (INIS)

Bailey, E.W.; Colleraine, A.; Doll, D.; Grunloh, H.; Kim, J.; Langhorn, A.; Thurgood, B.

1983-12-01

The Doublet III neutral beam injectors consist of three separable spools two meters in diameter by four meters long overall when assembled. Contained within these spools are the neutralizers, ion dumps, deflecting magnet, calorimeter dumps, cryogenic panels and beam scraping collimators 3,7. To date three beamlines are in operation on Doublet III, and the beams have accumulated operating time of approximately 32 months, with the oldest having been in operation for 18 months. During this time operation of DIII with the neutral beam sources has demonstrated the following: 7.8 MW injected neutrals from three beamlines (6 sources), high β (4.5%), and non-circular plasma shape. The sources have also exhibited a very reliable injected shot history 4, 5, 6, 8. Material failures encountered during the operation of DIII N.B. injectors and the solutions to these failures are described. Failures include cracking of the neutralizer exit collimator due to heating cycles, failure of cyropanel support rods due to cooling cycles, failure of the sliding drive of the moveable calorimeter due to friction

Fault detection and protection system for neutral beam generators on the Neutral Beam Engineering Test Facility (NBETF)

International Nuclear Information System (INIS)

deVries, G.J.; Chesley, K.L.; Owren, H.M.

1983-12-01

Neutral beam sources, their power supplies and instrumentation can be damaged from high voltage sparkdown or from overheating due to excessive currents. The Neutral Beam Engineering Test Facility (NBETF) in Berkeley has protective electronic hardware that senses a condition outside a safe operating range and generates a response to terminate such a fault condition. A description of this system is presented in this paper. 8 references, 2 figures, 2 tables

42 CFR 412.352 - Budget neutrality adjustment.

Science.gov (United States)

2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Budget neutrality adjustment. 412.352 Section 412.352 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... § 412.352 Budget neutrality adjustment. For FY 1992 through FY 1995, CMS will determine an adjustment to...

Neutralizing Antibodies and Pathogenesis of Hepatitis C Virus Infection

Directory of Open Access Journals (Sweden)

Françoise Stoll-Keller

2012-10-01

Full Text Available Hepatitis C virus (HCV infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing evidence that host neutralizing responses play a relevant role in the resulting pathogenesis. Furthermore, viral evasion from host neutralizing antibodies has been revealed to be an important contributor in leading both to viral persistence in acute liver graft infection following liver transplantation, and to chronic viral infection. The development of novel model systems to study HCV entry and neutralization has allowed a detailed understanding of the molecular mechanisms of virus-host interactions during antibody-mediated neutralization. The understanding of these mechanisms will ultimately contribute to the development of novel antiviral preventive strategies for liver graft infection and an urgently needed vaccine. This review summarizes recent concepts of the role of neutralizing antibodies in viral clearance and protection, and highlights consequences of viral escape from neutralizing antibodies in the pathogenesis of HCV infection.

Neutral-particle-beam production and injection

International Nuclear Information System (INIS)

Post, D.; Pyle, R.

1982-07-01

This paper is divided into two sections: the first is a discussion of the interactions of neutral beams with confined plasmas, the second is concerned with the production and diagnosis of the neutral beams. In general we are dealing with atoms, molecules, and ions of the isotopes of hydrogen, but some heavier elements (for example, oxygen) will be mentioned. The emphasis will be on single-particle collisions; selected atomic processes on surfaces will be included

Network Neutrality : A Survey of the Economic Literature

NARCIS (Netherlands)

Schuett, F.

2010-01-01

This paper reviews the small but growing economic literature on network neutrality. It considers a number of possible departures from network neutrality, in particular termination fees, second-degree price discrimination, and vertical foreclosure.

Cooling and trapping neutral atoms with radiative forces

International Nuclear Information System (INIS)

Bagnato, V.S.; Castro, J.C.; Li, M.S.; Zilio, S.C.

1988-01-01

Techniques to slow and trap neutral atoms at high densities with radiative forces are discussed in this review articles. Among several methods of laser cooling, it is emphasized Zeeman Tuning of the electronic levels and frequency-sweeping techniques. Trapping of neutral atoms and recent results obtained in light and magnetic traps are discussed. Techniques to further cool atoms inside traps are presented and the future of laser cooling of neutral atoms by means of radiation pressure is discussed. (A.C.A.S.) [pt

Hydrogen ion species analysis and related neutral beam injection power assessment in the Heliotron E neutral beam injection system

International Nuclear Information System (INIS)

Sano, Fumimichi; Obiki, Tokuhiro; Sasaki, Akihiko; Iiyoshi, Atsuo; Uo, Koji

1982-01-01

The hydrogen ion species in a Heliotron E neutral beam injection system of maximum electric power 6.3 MW were analyzed in order to assess the neutral beam power injected into the torus. The masimum p roton ratio of the cylindrical bucket type ion source used was observed to be more than 90 percent assuming that the angular divergences for the respective species in the beam are the same. The experimental data are compared with calculations using a particle balance model. The analysis indicates that the net injection power reaches nearly 2.7 MW at the optimal conditions of the system considering the geometrical limitation of the neutral beam path. (author)

Naturally selected hepatitis C virus polymorphisms confer broad neutralizing antibody resistance.

Science.gov (United States)

Bailey, Justin R; Wasilewski, Lisa N; Snider, Anna E; El-Diwany, Ramy; Osburn, William O; Keck, Zhenyong; Foung, Steven K H; Ray, Stuart C

2015-01-01

For hepatitis C virus (HCV) and other highly variable viruses, broadly neutralizing mAbs are an important guide for vaccine development. The development of resistance to anti-HCV mAbs is poorly understood, in part due to a lack of neutralization testing against diverse, representative panels of HCV variants. Here, we developed a neutralization panel expressing diverse, naturally occurring HCV envelopes (E1E2s) and used this panel to characterize neutralizing breadth and resistance mechanisms of 18 previously described broadly neutralizing anti-HCV human mAbs. The observed mAb resistance could not be attributed to polymorphisms in E1E2 at known mAb-binding residues. Additionally, hierarchical clustering analysis of neutralization resistance patterns revealed relationships between mAbs that were not predicted by prior epitope mapping, identifying 3 distinct neutralization clusters. Using this clustering analysis and envelope sequence data, we identified polymorphisms in E2 that confer resistance to multiple broadly neutralizing mAbs. These polymorphisms, which are not at mAb contact residues, also conferred resistance to neutralization by plasma from HCV-infected subjects. Together, our method of neutralization clustering with sequence analysis reveals that polymorphisms at noncontact residues may be a major immune evasion mechanism for HCV, facilitating viral persistence and presenting a challenge for HCV vaccine development.

Ballistic-neutralized chamber transport of intense heavy ion beams

International Nuclear Information System (INIS)

Rose, D.V.; Welch, D.R.; Oliver, B.V.; Clark, R.E.; Sharp, W.M.; Friedman, A.

2001-01-01

Two-dimensional particle-in-cell simulations of intense heavy ion beams propagating in an inertial confinement fusion (ICF) reactor chamber are presented. The ballistic-neutralized transport scheme studied uses 4 GeV Pb +1 ion beams injected into a low-density, gas-filled reactor chamber and the beam is ballistically focused onto an ICF target before entering the chamber. Charge and current neutralization of the beam is provided by the low-density background gas. The ballistic-neutralized simulations include stripping of the beam ions as the beam traverses the chamber as well as ionization of the background plasma. In addition, a series of simulations are presented that explore the charge and current neutralization of the ion beam in an evacuated chamber. For this vacuum transport mode, neutralizing electrons are only drawn from sources near the chamber entrance

Proton production, neutralisation and reduction in a floating water bridge

International Nuclear Information System (INIS)

Sammer, Martina; Wexler, Adam D; Kuntke, Philipp; Stanulewicz, Natalia; Lankmayr, Ernst; Woisetschläger, Jakob; Fuchs, Elmar C; Wiltsche, Helmar

2015-01-01

This work reports on proton production, transport, reduction and neutralization in floating aqueous bridges under the application of a high dc voltage (‘floating water bridge’). Recently possible mechanisms for proton transfer through the bridge were suggested. In this work we visualize and describe the production of protons in the anolyte and their neutralization in the catholyte. Apart from that, protons are reduced to hydrogen due to electrolysis. Microbubbles are detached instantly, due to the electrohydrodynamic flow at the electrode surface. No larger, visible bubbles are formed and the system degasses through the bridge due to its higher local temperature. A detailed analysis of trace elements originating from beaker material, anode or the atmosphere is presented, showing that their influence on the overall conduction compared to the contribution of protons is negligible. Finally, an electrochemical rationale of high voltage electrolysis of low ionic strength solutions is presented. (paper)

Proton production, neutralisation and reduction in a floating water bridge

Science.gov (United States)

Sammer, Martina; Wexler, Adam D.; Kuntke, Philipp; Wiltsche, Helmar; Stanulewicz, Natalia; Lankmayr, Ernst; Woisetschläger, Jakob; Fuchs, Elmar C.

2015-10-01

This work reports on proton production, transport, reduction and neutralization in floating aqueous bridges under the application of a high dc voltage (‘floating water bridge’). Recently possible mechanisms for proton transfer through the bridge were suggested. In this work we visualize and describe the production of protons in the anolyte and their neutralization in the catholyte. Apart from that, protons are reduced to hydrogen due to electrolysis. Microbubbles are detached instantly, due to the electrohydrodynamic flow at the electrode surface. No larger, visible bubbles are formed and the system degasses through the bridge due to its higher local temperature. A detailed analysis of trace elements originating from beaker material, anode or the atmosphere is presented, showing that their influence on the overall conduction compared to the contribution of protons is negligible. Finally, an electrochemical rationale of high voltage electrolysis of low ionic strength solutions is presented.

On the role of neutral flow in field-aligned currents

Science.gov (United States)

Mannucci, Anthony J.; Verkhoglyadova, Olga P.; Meng, Xing; McGranaghan, Ryan

2018-01-01

In this brief note we explore the role of the neutral atmosphere in magnetosphere-ionosphere coupling. We analyze momentum balance in the ion rest frame to form hypotheses regarding the role of neutral momentum in the lower ionosphere during geomagnetic storms. Neutral momentum that appears in the ion rest frame is likely the result of momentum imparted to ionospheric ions by solar wind flow and the resultant magnetospheric dynamics. The resulting ion-neutral collisions lead to the existence of an electric field. Horizontal electron flow balances the momentum supplied by this electric field. We suggest a possible role played by the neutral atmosphere in generating field-aligned currents due to local auroral heating. Our physical interpretation suggests that thermospheric neutral dynamics plays a complementary role to the high-latitude field-aligned currents and electric fields resulting from magnetospheric dynamics.

Design of a negative ion neutral beam system for TNS

International Nuclear Information System (INIS)

Easoz, J.R.

1978-05-01

A conceptual design of a neutral beam line based on the neutralization of negative deuterium ions is presented. This work is a detailed design of a complete neutral beam line based on using negative ions from a direct extraction source. Anticipating major technological advancements, beam line components have been scaled including the negative ion sources and components for the direct energy recovery of charged beams and high speed cryogenic pumping. With application to the next step in experimental fusion reactors (TNS), the neutral beam injector system that has been designed provides 10 MW of 200 keV neutral deuterium atoms. Several arms are required for plasma ignition

Neutral heavy lepton production in e+-e- collisions

International Nuclear Information System (INIS)

Ragiadakos, C.

1977-01-01

The cross-sections of the weak production of different kinds of neutral heavy leptons in e + -e - collisions are calculated and their signatures are studied. A possible electromagnetic production of neutral heavy leptons is also considered

Evidence for parity nonconservation in the weak neutral current

International Nuclear Information System (INIS)

Benvenuti, A.; Cline, D.; Messing, F.; Ford, W.; Imlay, R.; Ling, T.Y.; Mann, A.K.; Reeder, D.D.; Rubbia, C.; Stefanski, R.; Sulak, L.; Wanderer, P.

1976-01-01

Measurements of R/sup nu/ and R/sup nu-bar/, the ratios of neutral current to charged current ν and nu-bar cross sections, yield neutral current rates for ν and nu-bar that are consistent with a pure V-A interaction but 3 standard deviations from pure V or pure A, indicating the presence of parity nonconservation in the weak neutral current

Neutral currents without gauge theory prejudices

International Nuclear Information System (INIS)

Sakurai, J.J.

1976-01-01

The measurement of weak neutral current processes allows a determination of the space-time structure and the isospin structure of these currents. The inclusive production data and the elastic neutrino electron scattering rules out a pure V or A structure of the current. A pure isoscalar current is in disagreement with the experimental data for the one pion production off neutrinos. Further aspects of the neutral current can be determined in neutrino-nucleus-scattering experiments. (BJ) [de

A Rapid Zika Diagnostic Assay to Measure Neutralizing Antibodies in Patients

Directory of Open Access Journals (Sweden)

Chao Shan

2017-03-01

Full Text Available The potential association of microcephaly and other congenital abnormalities with Zika virus (ZIKV infection during pregnancy underlines the critical need for a rapid and accurate diagnosis. Due to the short duration of ZIKV viremia in infected patients, a serologic assay that detects antibody responses to viral infection plays an essential role in diagnosing patient specimens. The current serologic diagnosis of ZIKV infection relies heavily on the labor-intensive Plaque Reduction Neutralization Test (PRNT that requires more than one-week turnaround time and represents a major bottleneck for patient diagnosis. To overcome this limitation, we have developed a high-throughput assay for ZIKV and dengue virus (DENV diagnosis that can attain the “gold standard” of the current PRNT assay. The new assay is homogeneous and utilizes luciferase viruses to quantify the neutralizing antibody titers in a 96-well format. Using 91 human specimens, we showed that the reporter diagnostic assay has a higher dynamic range and maintains the relative specificity of the traditional PRNT assay. Besides the improvement of assay throughput, the reporter virus technology has also shortened the turnaround time to less than two days. Collectively, our results suggest that, along with the viral RT-PCR assay, the reporter virus-based serologic assay could be potentially used as the first-line test for clinical diagnosis of ZIKV infection as well as for vaccine clinical trials.

Cost-effectiveness of ranibizumab versus aflibercept in the treatment of visual impairment due to diabetic macular edema: a UK healthcare perspective

Directory of Open Access Journals (Sweden)

Régnier SA

2015-05-01

Full Text Available Stephane A Régnier,1 William Malcolm,2 Jennifer Haig,3 Weiguang Xue41Novartis Pharma AG, Basel, Switzerland; 2Novartis Pharmaceuticals UK Ltd, Frimley Business Park, UK; 3Optum, Burlington, ON, Canada; 4Optum, Uxbridge, UKBackground: Ranibizumab and aflibercept are alternative anti-vascular endothelial growth factor agents approved for the treatment of visual impairment (VI due to diabetic macular edema (DME.Objective: To estimate, from a UK healthcare perspective, the cost-effectiveness of ranibizumab 0.5 mg pro re nata (PRN and ranibizumab 0.5 mg treat and extend (T&E compared with aflibercept 2 mg every 8 weeks after five initial monthly doses (2q8 in the treatment of VI due to DME.Methods: A Markov model previously reviewed by the National Institute for Health and Care Excellence was used to simulate the long-term outcomes and costs of treating DME. Health states were defined by increments of ten letters in best-corrected visual acuity (BCVA, with a 3-month cycle length. Patients could gain (or lose a maximum of two health states between cycles. A 3-year treatment time frame and a lifetime horizon were used. Future costs and health outcomes were discounted at 3.5% per annum. Patient baseline characteristics and the efficacy of ranibizumab PRN were derived using data from the RESTORE study. The relative efficacies of ranibizumab PRN, ranibizumab T&E, and aflibercept were assessed with a network meta-analysis. Different utilities were assigned based on BCVA and whether the treated eye was the better- or the worse-seeing eye. Sensitivity analyses tested the robustness of the model.Results: Lifetime costs per patient of treating DME were £20,019 for ranibizumab PRN, £22,930 for ranibizumab T&E, and £25,859 for aflibercept 2q8. Ranibizumab was dominant over aflibercept, with an incremental gain of 0.05 quality-adjusted life-years (QALYs and cost savings of £5,841 (PRN and £2,930 (T&E compared with aflibercept. Ranibizumab PRN and

3He neutral current detectors at SNO

International Nuclear Information System (INIS)

Elliott, S.R.; Browne, M.C.; Doe, P.J.

1998-01-01

The flux of solar neutrinos measured via charged and neutral current interactions can provide a model independent test of neutrino oscillations. Since the Sudbury Neutrino Observatory uses heavy water as a target, it has a large sensitivity to both interactions. A technique for observing the neutral current breakup of the deuteron using 3 He proportional counters is described

Electrolytic 99mTcO4- reduction: a different pathway to obtain 99mTc-labelled compounds

International Nuclear Information System (INIS)

Savio, E.; Kremer, C.; Gambino, D.; Kremer, E.; Leon, A.

1991-01-01

Electrolytic reduction of 99m TcO 4 - at inert electrodes to obtain 99m Tc cationic complexes and in vitro stability of labelled compounds were studied. Amines were used as neutral N-donor ligands and a systematic analysis of various parameters involved in the reduction process was performed. Usefulness of electrolytic reduction was proved as an alternative 99m Tc-labelling method. Its most important advantages are: production of complexes with a high radiochemical purity, negligible presence of red-hyd- 99m Tc, lack of foreign materials, simplicity of development and possibility of further applications. (author)

Stability of Neutral Fractional Neural Networks with Delay

Institute of Scientific and Technical Information of China (English)

LI Yan; JIANG Wei; HU Bei-bei

2016-01-01

This paper studies stability of neutral fractional neural networks with delay. By introducing the definition of norm and using the uniform stability, the sufficient condition for uniform stability of neutral fractional neural networks with delay is obtained.

Modelling of neutral particle transport in divertor plasma

International Nuclear Information System (INIS)

Kakizuka, Tomonori; Shimizu, Katsuhiro

1995-01-01

An outline of the modelling of neutral particle transport in the diverter plasma was described in the paper. The characteristic properties of divertor plasma were largely affected by interaction between neutral particles and divertor plasma. Accordingly, the behavior of neutral particle should be investigated quantitatively. Moreover, plasma and neutral gas should be traced consistently in the plasma simulation. There are Monte Carlo modelling and the neutral gas fluid modelling as the transport modelling. The former need long calculation time, but it is able to make the physical process modelling. A ultra-large parallel computer is good for the former. In spite of proposing some kinds of models, the latter has not been established. At the view point of reducing calculation time, a work station is good for the simulation of the latter, although some physical problems have not been solved. On the Monte Carlo method particle modelling, reducing the calculation time and introducing the interaction of particles are important subjects to develop 'the evolutional Monte Carlo Method'. To reduce the calculation time, two new methods: 'Implicit Monte Carlo method' and 'Free-and Diffusive-Motion Hybrid Monte-Carlo method' have been developing. (S.Y.)

Are Synonymous Substitutions in Flowering Plant Mitochondria Neutral?

Science.gov (United States)

Wynn, Emily L; Christensen, Alan C

2015-10-01

Angiosperm mitochondrial genes appear to have very low mutation rates, while non-gene regions expand, diverge, and rearrange quickly. One possible explanation for this disparity is that synonymous substitutions in plant mitochondrial genes are not truly neutral and selection keeps their occurrence low. If this were true, the explanation for the disparity in mutation rates in genes and non-genes needs to consider selection as well as mechanisms of DNA repair. Rps14 is co-transcribed with cob and rpl5 in most plant mitochondrial genomes, but in some genomes, rps14 has been duplicated to the nucleus leaving a pseudogene in the mitochondria. This provides an opportunity to compare neutral substitution rates in pseudogenes with synonymous substitution rates in the orthologs. Genes and pseudogenes of rps14 have been aligned among different species and the mutation rates have been calculated. Neutral substitution rates in pseudogenes and synonymous substitution rates in genes are significantly different, providing evidence that synonymous substitutions in plant mitochondrial genes are not completely neutral. The non-neutrality is not sufficient to completely explain the exceptionally low mutation rates in land plant mitochondrial genomes, but selective forces appear to play a small role.

Confinement of pure electron plasmas in the Columbia Non-neutral Torus

International Nuclear Information System (INIS)

Berkery, John W.; Pedersen, Thomas Sunn; Kremer, Jason P.; Marksteiner, Quinn R.; Lefrancois, Remi G.; Hahn, Michael S.; Brenner, Paul W.

2007-01-01

The Columbia Non-neutral Torus (CNT) [T. S. Pedersen, J. P. Kremer, R. G. Lefrancois, Q. Marksteiner, N. Pomphrey, W. Reiersen, F. Dahlgreen, and X. Sarasola, Fusion Sci. Technol. 50, 372 (2006)] is a stellarator used to study non-neutral plasmas confined on magnetic surfaces. A detailed experimental study of confinement of pure electron plasmas in CNT is described here. Electrons are introduced into the magnetic surfaces by placing a biased thermionic emitter on the magnetic axis. As reported previously, the insulated rods holding this and other emitter filaments contribute to the radial transport by charging up negatively and creating ExB convective transport cells. A model for the rod-driven transport is presented and compared to the measured transport rates under a number of different conditions, finding good agreement. Neutrals also drive transport, and by varying the neutral pressure in the experiment, the effects of rod-driven and neutral-driven transport are separated. The neutral-driven electron loss rate scales linearly with neutral pressure. The neutral driven transport, presumably caused by electron-neutral collisions, is much greater than theoretical estimates for neoclassical diffusion in a classical stellarator with strong radial electric fields. In fact the confinement time is on the order of the electron-neutral collision time. Ion accumulation, electron attachment, and other effects are considered, but do not explain the observed transport rates

PDX neutral-beam reionization losses

International Nuclear Information System (INIS)

Kugel, H.W.; Dylla, H.F.; Eubank, H.P.; Kozub, T.A.; Moore, R.; Schilling, G.; Stewart, L.D.; von Halle, A.; Williams, M.D.

1982-02-01

Reionization losses for 1.5 MW H 0 and 2 MW D 0 neutral beams injected into the PDX tokamak were studied using pressure gauges, photo-transistors, thermocouples, surface shielding, and surface sample analysis. Considerable outgassing of conventionally prepared 304SS ducts occurred during initial injections and gradually decreased with the cumulative absorption of beam power. Reionization power losses are presently about 5% in the ducts and about 12% total for a beamline including the duct. Present duct pressures are attributed primarily to gas from the ion source and neutralizer with much smaller contributions from residual wall desorption. Physical mechanisms for the observed duct outgassing are discussed

On the role of neutral flow in field-aligned currents

Directory of Open Access Journals (Sweden)

A. J. Mannucci

2018-01-01

Full Text Available In this brief note we explore the role of the neutral atmosphere in magnetosphere–ionosphere coupling. We analyze momentum balance in the ion rest frame to form hypotheses regarding the role of neutral momentum in the lower ionosphere during geomagnetic storms. Neutral momentum that appears in the ion rest frame is likely the result of momentum imparted to ionospheric ions by solar wind flow and the resultant magnetospheric dynamics. The resulting ion-neutral collisions lead to the existence of an electric field. Horizontal electron flow balances the momentum supplied by this electric field. We suggest a possible role played by the neutral atmosphere in generating field-aligned currents due to local auroral heating. Our physical interpretation suggests that thermospheric neutral dynamics plays a complementary role to the high-latitude field-aligned currents and electric fields resulting from magnetospheric dynamics.

Kinetic Properties of the Neutral Solar Wind

International Nuclear Information System (INIS)

Florinski, V.; Heerikhuisen, J.

2017-01-01

Charge-exchange collisions between the solar wind protons and interstellar hydrogen produce a distinctive population of neutral hydrogen streaming radially at nearly the solar-wind speed. This tenuous population, known as the neutral solar wind (NSW) is thought to play a key role in the appearance of the Interplanetary Boundary EXplorer ribbon, a bright circular band in the sky that is the source of neutral hydrogen with energies near 1 keV. According to the leading model of the ribbon, the velocity distribution of NSW hydrogen is imparted on the pickup ions (PUIs) generated via charge exchange with the interstellar protons beyond the heliopause, and in this way controls the stability of the resulting ring distribution of PUIs against hydromagnetic wave generation. In this paper, we examine the velocity distributions of the NSW atoms in the heliosphere and the outer heliosheath regions by following the phase-space trajectories of the Boltzmann equation. It is demonstrated that these distributions are highly anisotropic, with the parallel (radial) temperature greatly exceeding the perpendicular temperature. Ions picked up near 90° from the anisotropic NSW would form a stable ring distribution capable of generating the ribbon flux. We also discuss a second population of neutrals born in charge transfer collisions with interstellar PUIs, the so-called neutralized pickup ion (NPI) component. Their high thermal velocities translate into large parallel velocity spread of the daughter ribbon PUIs, which would adversely affect plasma stability in local interstellar space.

Kinetic Properties of the Neutral Solar Wind

Science.gov (United States)

Florinski, V.; Heerikhuisen, J.

2017-03-01

Charge-exchange collisions between the solar wind protons and interstellar hydrogen produce a distinctive population of neutral hydrogen streaming radially at nearly the solar-wind speed. This tenuous population, known as the neutral solar wind (NSW) is thought to play a key role in the appearance of the Interplanetary Boundary EXplorer ribbon, a bright circular band in the sky that is the source of neutral hydrogen with energies near 1 keV. According to the leading model of the ribbon, the velocity distribution of NSW hydrogen is imparted on the pickup ions (PUIs) generated via charge exchange with the interstellar protons beyond the heliopause, and in this way controls the stability of the resulting ring distribution of PUIs against hydromagnetic wave generation. In this paper, we examine the velocity distributions of the NSW atoms in the heliosphere and the outer heliosheath regions by following the phase-space trajectories of the Boltzmann equation. It is demonstrated that these distributions are highly anisotropic, with the parallel (radial) temperature greatly exceeding the perpendicular temperature. Ions picked up near 90° from the anisotropic NSW would form a stable ring distribution capable of generating the ribbon flux. We also discuss a second population of neutrals born in charge transfer collisions with interstellar PUIs, the so-called neutralized pickup ion (NPI) component. Their high thermal velocities translate into large parallel velocity spread of the daughter ribbon PUIs, which would adversely affect plasma stability in local interstellar space.

[Immunogenicity and protective efficacy of pertactin recombinants against Bordetella bronchiseptica challenge].

Science.gov (United States)

Zhao, Zhanqin; Wang, Chen; Xue, Yun; Ding, Ke; Zhang, Chunjie; Cheng, Xiangchao; Li, Yinju; Liu, Yichen; Wu, Tingcai

2010-09-01

In this study we showed the immunogenicity and protective efficacy of five pertactin recombinants against Bordetella bronchiseptica (Bb) challenge. The complete coding sequence (2040 bp) of the prn gene (PRN) and its fragments,5'-terminal 1173 bp fragment (PN),3'-terminal 867 bp fragment (PC), two copies of region I (654 bp; PR I) in PN, and 2 copies of region II (678 bp; PR II) in PC, were separately cloned into the prokaryotic expression vector pGEX-KG, and expressed in the Eschierichia coli BL21 (DE3) using induction by isopropyl-beta-D-thiogalactopyranoside. The recombinant proteins were named GST-PRN, GST-PN, GST-PC, GST-2PR I and GST-2PR II. All five recombinant proteins showed immunological reactivity in the Western-blot analysis. Mice, immunized subcutaneously with two doses of the purified proteins mixed with an equal volume of Freund's adjuvant,produced robust PRN-specific IgG antibody levels. When challenged, 6 of 9 mice in GST-2PR I group and all 9 mice in the other groups survived intranasal challenge with three times the 50% lethal dose (LD50) of virulent Bb HH0809. After challenge with 10 LD50 7/9,3/9,6/9,1/10 and 6/10 of the mice survived. Furthermore, complete protection against intraperitoneal (i.p.) challenge with 10 LD50 of HH0809 was observed in mice that were injected i.p. with 0.5 ml rabbit anti-GST-PRN, GST-PN,GST-PC or GST-2PR II serum. Only 1 of 10 mice survived in the group of mice that received anti-GST-2PR I, and no survivors were noted in the group of mice that received PRN-absorbed rabbit antiserum (0/5). In this study,we showed that all of five pertactin recombinants had differential immunogenicity and protective efficacy against Bb challenge. Mice immunized with GST-PC had better survival against fatal Bb challenge than did those immunized with GST-PN. In addition, GST-2PR II and GST-2PR I provided the similar results These data may have implications for the development of safe and efficacious subunit vaccines for the prevention of

Neutralization of positive particle beams by electron trapping

International Nuclear Information System (INIS)

Mobley, R.M.; Irani, A.A.; LeMaire, J.L.; Maschke, A.W.

1977-01-01

Initial results are presented of a planned series of experimental tests of positive ion beam neutralization, involving transverse space charge studies of a 720 keV 60mA H + beam in a drift region of 4.6 meters. Two conclusions drawn from the data are: (1) the change in transmission observed is consistent with complete neutralization in the drift pipe for grounded or negative electrodes, and with complete de-neutralization in the case of greater than +240 V electrodes; and (2) background gas ionization cannot be the main source of electrons

Neutral beam systems for the magnetic fusion program

International Nuclear Information System (INIS)

Beal, J.W.; Staten, H.S.

1977-01-01

The attainment of economic, safe fusion power has been described as the most sophisticated scientific problem ever attacked by mankind. The presently established goal of the magnetic fusion program is to develop and demonstrate pure fusion central electric power stations for commercial applications. Neutral beam heating systems are a basic component of the tokamak and mirror experimental fusion plasma confinement devices. The requirements placed upon neutral beam heating systems are reviewed. The neutral beam systems in use or being developed are presented. Finally, the needs of the future are discussed

Industrialization and production of neutral beam ion sources for MFTF

International Nuclear Information System (INIS)

Lynch, W.S.

1981-01-01

The existing LLNL designs of the 20 and 80kV deuterium fueled Neutral Beam Ion Source Modules (NBSM) have been industrialized and are being produced successfully for the MFTF. Industrialization includes value engineering, production engineering, cost reduction, fixturing, facilitation and procurement of components. Production assembly, inspection and testing is being performed in a large electronics manufacturing plant. Decades of experience in high voltage, high vacuum power tubes is being applied to the procedures and processes. Independent quality and reliability assurance criteria are being utilized. Scheduling of the various engineering, procurement and manufacturing task is performed by the use of a Critical Path Method (CPM) computer code, Innovative, computerized grid alignment methods were also designed and installed specifically for this project. New jointing and cleaning techniques were devised for the NBSMs. Traceability and cost control are also utilized

Dynamics of ion beam charge neutralization by ferroelectric plasma sources

Energy Technology Data Exchange (ETDEWEB)

Stepanov, Anton D.; Gilson, Erik P.; Grisham, Larry R.; Kaganovich, Igor D.; Davidson, Ronald C. [Princeton Plasma Physics Laboratory, Princeton University, P.O. Box 451, Princeton, New Jersey 08543 (United States)

2016-04-15

Ferroelectric Plasma Sources (FEPSs) can generate plasma that provides effective space-charge neutralization of intense high-perveance ion beams, as has been demonstrated on the Neutralized Drift Compression Experiment NDCX-I and NDCX-II. This article presents experimental results on charge neutralization of a high-perveance 38 keV Ar{sup +} beam by a plasma produced in a FEPS discharge. By comparing the measured beam radius with the envelope model for space-charge expansion, it is shown that a charge neutralization fraction of 98% is attainable with sufficiently dense FEPS plasma. The transverse electrostatic potential of the ion beam is reduced from 15 V before neutralization to 0.3 V, implying that the energy of the neutralizing electrons is below 0.3 eV. Measurements of the time-evolution of beam radius show that near-complete charge neutralization is established ∼5 μs after the driving pulse is applied to the FEPS and can last for 35 μs. It is argued that the duration of neutralization is much longer than a reasonable lifetime of the plasma produced in the sub-μs surface discharge. Measurements of current flow in the driving circuit of the FEPS show the existence of electron emission into vacuum, which lasts for tens of μs after the high voltage pulse is applied. It is argued that the beam is neutralized by the plasma produced by this process and not by a surface discharge plasma that is produced at the instant the high-voltage pulse is applied.

HIV-1 binding and neutralizing antibodies of injecting drug users

Directory of Open Access Journals (Sweden)

E.P. Ouverney

2005-09-01

Full Text Available Previous studies have demonstrated a stronger seroreactivity against some synthetic peptides responsible for inducing neutralizing antibodies in injecting drug users (IDU compared to that of individuals sexually infected with HIV-1 (S, but the effectiveness in terms of the neutralizing ability of these antibodies has not been evaluated. Our objective was to study the humoral immune response of IDU by determining the specificity of their antibodies and the presence of neutralizing antibodies. The neutralization capacity against the HIV-1 isolate MN (genotype B, the primary HIV-1 isolate 95BRRJ021 (genotype F, and the seroreactivity with peptides known to induce neutralizing antibodies, from the V2 and V3 loops of different HIV-1 subtypes, were analyzed. Seroreactivity indicates that IDU plasma are more likely to recognize a broader range of peptides than S plasma, with significantly higher titers, especially of V3 peptides. Similar neutralization frequencies of the MN isolate were observed in plasma of the IDU (16/47 and S (20/60 groups in the 1:10 dilution. The neutralization of the 95BRRJ021 isolate was more frequently observed for plasma from the S group (15/23 than from the IDU group (15/47, P = 0.0108. No correlation between neutralization and seroreactivity with the peptides tested was observed. These results suggest that an important factor responsible for the extensive and broad humoral immune response observed in IDU is their infection route. There was very little difference in neutralizing antibody response between the IDU and S groups despite their differences in seroreactivity and health status.

Apparatus for neutralization of accelerated ions

International Nuclear Information System (INIS)

Fink, J.H.; Frank, A.M.

1979-01-01

Apparatus is described for neutralization of a beam of accelerated ions, such as hydrogen negative ions (H - ), using relatively efficient strip diode lasers which emit monochromatically at an appropriate wavelength (lambda = 8000 A for H - ions) to strip the excess electrons by photodetachment. A cavity, formed by two or more reflectors spaced apart, causes the laser beams to undergo multiple reflections within the cavity, thus increasing the efficiency and reducing the illumination required to obtain an acceptable percentage (approx. 85%) of neutralization

STATISTICAL ANALYSIS OF THE HEAVY NEUTRAL ATOMS MEASURED BY IBEX

International Nuclear Information System (INIS)

Park, Jeewoo; Kucharek, Harald; Möbius, Eberhard; Galli, André; Livadiotis, George; Fuselier, Steve A.; McComas, David J.

2015-01-01

We investigate the directional distribution of heavy neutral atoms in the heliosphere by using heavy neutral maps generated with the IBEX-Lo instrument over three years from 2009 to 2011. The interstellar neutral (ISN) O and Ne gas flow was found in the first-year heavy neutral map at 601 keV and its flow direction and temperature were studied. However, due to the low counting statistics, researchers have not treated the full sky maps in detail. The main goal of this study is to evaluate the statistical significance of each pixel in the heavy neutral maps to get a better understanding of the directional distribution of heavy neutral atoms in the heliosphere. Here, we examine three statistical analysis methods: the signal-to-noise filter, the confidence limit method, and the cluster analysis method. These methods allow us to exclude background from areas where the heavy neutral signal is statistically significant. These methods also allow the consistent detection of heavy neutral atom structures. The main emission feature expands toward lower longitude and higher latitude from the observational peak of the ISN O and Ne gas flow. We call this emission the extended tail. It may be an imprint of the secondary oxygen atoms generated by charge exchange between ISN hydrogen atoms and oxygen ions in the outer heliosheath

El liberalismo conservador y la ideología del Proceso de Reorganización Nacional

Directory of Open Access Journals (Sweden)

Sergio Morresi

2010-06-01

Full Text Available This article aims to show that the political ideas of the selfnamed "National Reorganization Process -Proceso de Reorganización Nacional [PRN]" -were structured within the ideological frame offered by conservative-liberalism. Through the study of some of the ideologicalpromoters of the PRN, it is argued that conservative-liberalism served as merger of the different types of argentinian rights and laid the foundations for the neoliberal ideas that were impelled afer the dictatorship period

A Study of Charge-Exchange Neutrals from a Rotating Plasma

DEFF Research Database (Denmark)

Jørgensen, L. W.; Sillesen, Alfred Hegaard

1980-01-01

Measurements of charge-exchange neutrals leaving a rotating plasma (a puffatron device) are reported. Neutrals are observed only during the breakdown phase (2-3 mu s) indicating that the created plasma is fully ionized. Several energy spectra of the neutrals for different plasma parameters are ob....... Neutral particle measurements at different distances from the puffatron midplane show ionization velocities parallel with the magnetic field of about 2*104 ms-1 and plasma expansion velocities of about 5-6*104 ms-1 corresponding to an electron temperature of about 25 eV.......Measurements of charge-exchange neutrals leaving a rotating plasma (a puffatron device) are reported. Neutrals are observed only during the breakdown phase (2-3 mu s) indicating that the created plasma is fully ionized. Several energy spectra of the neutrals for different plasma parameters...... are obtained. These spectra are grossly explained using a single-particle orbit model of the plasma ions. Assuming a Maxwellian distribution for the spread in the ion Larmor energy for the central part of the measured energy spectra, it is possible to determine the ion energy during the breakdown phase...

Neutralized drift compression experiments with a high-intensity ion beam

International Nuclear Information System (INIS)

Roy, P.K.; Yu, S.S.; Waldron, W.L.; Anders, A.; Baca, D.; Barnard, J.J.; Bieniosek, F.M.; Coleman, J.; Davidson, R.C.; Efthimion, P.C.; Eylon, S.; Friedman, A.; Gilson, E.P.; Greenway, W.G.; Henestroza, E.; Kaganovich, I.; Leitner, M.; Logan, B.G.; Sefkow, A.B.; Seidl, P.A.; Sharp, W.M.; Thoma, C.; Welch, D.R.

2007-01-01

To create high-energy density matter and fusion conditions, high-power drivers, such as lasers, ion beams, and X-ray drivers, may be employed to heat targets with short pulses compared to hydro-motion. Both high-energy density physics and ion-driven inertial fusion require the simultaneous transverse and longitudinal compression of an ion beam to achieve high intensities. We have previously studied the effects of plasma neutralization for transverse beam compression. The scaled experiment, the Neutralized Transport Experiment (NTX), demonstrated that an initially un-neutralized beam can be compressed transversely to ∼1 mm radius when charge neutralization by background plasma electrons is provided. Here, we report longitudinal compression of a velocity-tailored, intense, neutralized 25 mA K + beam at 300 keV. The compression takes place in a 1-2 m drift section filled with plasma to provide space-charge neutralization. An induction cell produces a head-to-tail velocity ramp that longitudinally compresses the neutralized beam, enhances the beam peak current by a factor of 50 and produces a pulse duration of about 3 ns. The physics of longitudinal compression, experimental procedure, and the results of the compression experiments are presented

Efficient solar-assisted O2 reduction by a cofacial iron porphyrin dimer integrated to a p-CuBi2O4 photocathode prepared by a simple novel method.

Science.gov (United States)

Zahran, Zaki N; Mohamed, Eman A; Naruta, Yoshinori; Haleem, Ashraf

2017-10-04

A cofacial iron porphyrin hetero-dimer, Fe2TPFPP-TMP showed high electro-catalytic activity, selectivity, and stability for the O2 reduction to H2O both in homogeneous non-aqueous and heterogeneous neutral aqueous solutions. Moreover, when it is integrated to FTO/p-CuBi2O4 (FTO = fluorine doped tin oxide) photocathode prepared by a simple novel method, a remarkable efficient solar-assisted O2 reduction is achieved in neutral potassium phosphate (KPi) or basic NaOH solutions saturated with O2. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Neutralization kinetics of charged polymer surface

Energy Technology Data Exchange (ETDEWEB)

Mukherjee, S. [Surface Physics Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata 700064 (India); Mukherjee, M. [Surface Physics Division, Saha Institute of Nuclear Physics, 1/AF, Bidhannagar, Kolkata 700064 (India)], E-mail: manabendra.mukherjee@saha.ac.in

2008-04-15

In case of photoemission spectroscopy of an insulating material the data obtained from the charged surface are normally distorted due to differential charging. Recently, we have developed a controlled surface neutralization technique to study the kinetics of the surface charging. Using this technique and the associated data analysis scheme with an effective charging model, quantitative information from the apparently distorted photoemission data from PTFE surfaces were extracted. The surface charging was controlled by tuning the electron flood current as well as the X-ray intensity. The effective model was found to describe the charging consistently for both the cases. It was shown that the non-linear neutralization response of differential charging around a critical neutralizing electron flux or a critical X-ray emission current was due to percolation of equipotential surface domains. The obtained value of the critical percolation exponent {gamma} close to unity indicates a percolation similar to that of avalanche breakdown or chain reaction.

Antibody neutralization of retargeted measles viruses

Science.gov (United States)

Lech, Patrycja J.; Pappoe, Roland; Nakamura, Takafumi; Tobin, Gregory J.; Nara, Peter L.; Russell, Stephen J.

2014-01-01

The measles virus (MV) vaccine lineage is a promising oncolytic but prior exposure to the measles vaccine or wild-type MV strains limits treatment utility due to the presence of anti-measles antibodies. MV entry can be redirected by displaying a polypeptide ligand on the Hemagglutinin (H) C-terminus. We hypothesized that retargeted MV would escape neutralization by monoclonal antibodies (mAbs) recognizing the H receptor-binding surface and be less susceptible to neutralization by human antisera. Using chimeric H proteins, with and without mutations that ablate MV receptor binding, we show that retargeted MVs escape mAbs that target the H receptor-binding surface by virtue of mutations that ablate infection via SLAM and CD46. However, C-terminally displayed domains do not mediate virus entry in the presence of human antibodies that bind to the underlying H domain. In conclusion, utility of retargeted oncolytic measles viruses does not extend to evasion of human serum neutralization. PMID:24725950

Curriculum and instructional methods for drug information, literature evaluation, and biostatistics: survey of US pharmacy schools.

Science.gov (United States)

Phillips, Jennifer A; Gabay, Michael P; Ficzere, Cathy; Ward, Kristina E

2012-06-01

The drug information curriculum in US colleges of pharmacy continues to evolve. The American College of Clinical Pharmacy (ACCP) Drug Information Practice and Research Network (DI PRN) published an opinion paper with specific recommendations regarding drug information education in 2009. Adoption of these recommendations has not been evaluated. To assess which recommendations made in the ACCP DI PRN opinion paper are included in US pharmacy school curricula and characterize faculty qualifications, educational methods, and recent changes in drug information education. An electronic survey was designed using the ACCP DI PRN opinion paper and the Accreditation Council for Pharmacy Education standards and guidelines for accreditation of PharmD programs in the US. Survey questions addressed curricular content within the following categories: drug information, literature evaluation, and biostatistics. A letter including the online survey link was sent via email to the dean of each US college/school of pharmacy (N = 128). Recipients were instructed to forward the email to the individual at their institution who was the most knowledgeable about the content and methodology used for didactic drug information education. Sixty-four responses were included in the final analysis. Of the 19 ACCP DI PRN minimum core concepts, 9 (47%) were included in curricula of all responding institutions; 14 of 19 (74%) were included in curricula for all but 1 institution. In contrast, 5 of 16 concepts (31%) were not formally taught by a number of institutions. Many respondents noted an increased focus on evidence-based medicine, medication safety, and informatics. Although a survey of drug information curricula documented substantial inclusion of the essential concepts presented in the ACCP DI PRN opinion paper, room for improvement remains in drug information curricula in US colleges of pharmacy.

A Prediction Model to Help with the Assessment of Adenopathy in Lung Cancer: HAL.

Science.gov (United States)

O'Connell, Oisin J; Almeida, Francisco A; Simoff, Michael J; Yarmus, Lonny; Lazarus, Ray; Young, Benjamin; Chen, Yu; Semaan, Roy; Saettele, Timothy M; Cicenia, Joseph; Bedi, Harmeet; Kliment, Corrine; Li, Liang; Sethi, Sonali; Diaz-Mendoza, Javier; Feller-Kopman, David; Song, Juhee; Gildea, Thomas; Lee, Hans; Grosu, Horiana B; Machuzak, Michael; Rodriguez-Vial, Macarena; Eapen, George A; Jimenez, Carlos A; Casal, Roberto F; Ost, David E

2017-06-15

Estimating the probability of finding N2 or N3 (prN2/3) malignant nodal disease on endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with non-small cell lung cancer (NSCLC) can facilitate the selection of subsequent management strategies. To develop a clinical prediction model for estimating the prN2/3. We used the AQuIRE (American College of Chest Physicians Quality Improvement Registry, Evaluation, and Education) registry to identify patients with NSCLC with clinical radiographic stage T1-3, N0-3, M0 disease that had EBUS-TBNA for staging. The dependent variable was the presence of N2 or N3 disease (vs. N0 or N1) as assessed by EBUS-TBNA. Univariate followed by multivariable logistic regression analysis was used to develop a parsimonious clinical prediction model to estimate prN2/3. External validation was performed using data from three other hospitals. The model derivation cohort (n = 633) had a 25% prevalence of malignant N2 or N3 disease. Younger age, central location, adenocarcinoma histology, and higher positron emission tomography-computed tomography N stage were associated with a higher prN2/3. Area under the receiver operating characteristic curve was 0.85 (95% confidence interval, 0.82-0.89), model fit was acceptable (Hosmer-Lemeshow, P = 0.62; Brier score, 0.125). We externally validated the model in 722 patients. Area under the receiver operating characteristic curve was 0.88 (95% confidence interval, 0.85-0.90). Calibration using the general calibration model method resulted in acceptable goodness of fit (Hosmer-Lemeshow test, P = 0.54; Brier score, 0.132). Our prediction rule can be used to estimate prN2/3 in patients with NSCLC. The model has the potential to facilitate clinical decision making in the staging of NSCLC.

On the possible eigenoscillations of neutral sheets

International Nuclear Information System (INIS)

Almeida, W.A.; Costa, J.M. da; Aruquipa, E.G.; Sudano, J.P.

1974-12-01

A neutral sheet model with hyperbolic tangent equilibrium magnetic field and hyperbolic square secant density profiles is considered. It is shown that the equation for small oscillations takes the form of an eigenvalue oscillation problem. Computed eigenfrequencies of the geomagnetic neutral sheet were found to be in the range of the resonant frequencies of the geomagnetic plasma sheet computed by other authors

Impaired acid neutralization in the duodenum in pancreatic insufficiency.

Science.gov (United States)

Dutta, S K; Russell, R M; Iber, F L

1979-10-01

The influence of severe exocrine pancreatic disease on the acid-neutralizing capacity of the duodenum was studied in five patients with pancreatic insufficiency (PI) and six control subjects using duodenal perfusion-marker technique. Hydrochloric acid (0.1 N containing 1% PEG) was infused at constant rates (1.2, 4.5 and 7.0 ml/min) into the duodenum just distal to the duodenal bulb. Samples were aspirated from the tip of the duodenal perfusion tube located at the ligament of Treitz. All samples were analyzed for volume, pH, titrable acidity, PEG and [14C]PEG (gastric marker) determination. Patients with PI demonstrated significantly diminished ability to neutralize various acid loads as compared to controls who virtually completely neutralized acid loads in the range of maximal gastric acid secretion. Exogenous secretin did not significantly improve percent acid neutralized in PI. These data clearly indicate that patients with PI have significantly impaired ability to neutralize even small loads of acid in the duodenum.

Neutral Community Dynamics and the Evolution of Species Interactions.

Science.gov (United States)

Coelho, Marco Túlio P; Rangel, Thiago F

2018-04-01

A contemporary goal in ecology is to determine the ecological and evolutionary processes that generate recurring structural patterns in mutualistic networks. One of the great challenges is testing the capacity of neutral processes to replicate observed patterns in ecological networks, since the original formulation of the neutral theory lacks trophic interactions. Here, we develop a stochastic-simulation neutral model adding trophic interactions to the neutral theory of biodiversity. Without invoking ecological differences among individuals of different species, and assuming that ecological interactions emerge randomly, we demonstrate that a spatially explicit multitrophic neutral model is able to capture the recurrent structural patterns of mutualistic networks (i.e., degree distribution, connectance, nestedness, and phylogenetic signal of species interactions). Nonrandom species distribution, caused by probabilistic events of migration and speciation, create nonrandom network patterns. These findings have broad implications for the interpretation of niche-based processes as drivers of ecological networks, as well as for the integration of network structures with demographic stochasticity.

Neutral Atom Diffusion in a Partially Ionized Prominence Plasma

Science.gov (United States)

Gilbert, Holly

2010-01-01

The support of solar prominences is normally described in terms of a magnetic force on the prominence plasma that balances the solar gravitational force. Because the prominence plasma is only partially ionized. it is necessary to consider in addition the support of the neutral component of the prominence plasma. This support is accomplished through a frictional interaction between the neutral and ionized components of the plasma, and its efficacy depends strongly on the degree of ionization of the plasma. More specifically, the frictional force is proportional to the relative flow of neutral and ion species, and for a sufficiently weakly ionized plasma, this flow must be relatively large to produce a frictional force that balances gravity. A large relative flow, of course, implies significant draining of neutral particles from the prominence. We evaluate the importance of this draining effect for a hydrogen-helium plasma, and consider the observational evidence for cross-field diffusion of neutral prominence material,

Reactive formulations for a neutralization of toxic industrial chemicals

Science.gov (United States)

Tucker, Mark D [Albuqueruqe, NM; Betty, Rita G [Rio Rancho, NM

2006-10-24

Decontamination formulations for neutralization of toxic industrial chemicals, and methods of making and using same. The formulations are effective for neutralizing malathion, hydrogen cyanide, sodium cyanide, butyl isocyanate, carbon disulfide, phosgene gas, capsaicin in commercial pepper spray, chlorine gas, anhydrous ammonia gas; and may be effective at neutralizing hydrogen sulfide, sulfur dioxide, formaldehyde, ethylene oxide, methyl bromide, boron trichloride, fluorine, tetraethyl pyrophosphate, phosphorous trichloride, arsine, and tungsten hexafluoride.

Neutral particle dynamics in the Alcator C-Mod tokamak

Energy Technology Data Exchange (ETDEWEB)

Niemczewski, Artur P. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

1995-08-01

This thesis presents an experimental study of neutral particle dynamics in the Alcator C-Mod tokamak. The primary diagnostic used is a set of six neutral pressure gauges, including special-purpose gauges built for in situ tokamak operation. While a low main chamber neutral pressure coincides with high plasma confinement regimes, high divertor pressure is required for heat and particle flux dispersion in future devices such as ITER. Thus we examine conditions that optimize divertor compression, defined here as a divertor-to-midplane pressure ratio. We find both pressures depend primarily on the edge plasma regimes defined by the scrape-off-layer heat transport. While the maximum divertor pressure is achieved at high core plasma densities corresponding to the detached divertor state, the maximum compression is achieved in the high-recycling regime. Variations in the divertor geometry have a weaker effect on the neutral pressures. For otherwise similar plasmas the divertor pressure and compression are maximum when the strike point is at the bottom of the vertical target plate. We introduce a simple flux balance model, which allows us to explain the divertor neutral pressure across a wide range of plasma densities. In particular, high pressure sustained in the detached divertor (despite a considerable drop in the recycling source) can be explained by scattering of neutrals off the cold plasma plugging the divertor throat. Because neutrals are confined in the divertor through scattering and ionization processes (provided the mean-free-paths are much shorter than a typical escape distance) tight mechanical baffling is unnecessary. The analysis suggests that two simple structural modifications may increase the divertor compression in Alcator C-Mod by a factor of about 5. Widening the divertor throat would increase the divertor recycling source, while closing leaks in the divertor structure would eliminate a significant neutral loss mechanism.

Neutral particle dynamics in the Alcator C-Mod tokamak

International Nuclear Information System (INIS)

Niemczewski, A.P.

1995-08-01

This thesis presents an experimental study of neutral particle dynamics in the Alcator C-Mod tokamak. The primary diagnostic used is a set of six neutral pressure gauges, including special-purpose gauges built for in situ tokamak operation. While a low main chamber neutral pressure coincides with high plasma confinement regimes, high divertor pressure is required for heat and particle flux dispersion in future devices such as ITER. Thus we examine conditions that optimize divertor compression, defined here as a divertor-to-midplane pressure ratio. We find both pressures depend primarily on the edge plasma regimes defined by the scrape-off-layer heat transport. While the maximum divertor pressure is achieved at high core plasma densities corresponding to the detached divertor state, the maximum compression is achieved in the high-recycling regime. Variations in the divertor geometry have a weaker effect on the neutral pressures. For otherwise similar plasmas the divertor pressure and compression are maximum when the strike point is at the bottom of the vertical target plate. We introduce a simple flux balance model, which allows us to explain the divertor neutral pressure across a wide range of plasma densities. In particular, high pressure sustained in the detached divertor (despite a considerable drop in the recycling source) can be explained by scattering of neutrals off the cold plasma plugging the divertor throat. Because neutrals are confined in the divertor through scattering and ionization processes (provided the mean-free-paths are much shorter than a typical escape distance) tight mechanical baffling is unnecessary. The analysis suggests that two simple structural modifications may increase the divertor compression in Alcator C-Mod by a factor of about 5. Widening the divertor throat would increase the divertor recycling source, while closing leaks in the divertor structure would eliminate a significant neutral loss mechanism. 146 refs., 82 figs., 14 tabs

The zero-sum assumption in neutral biodiversity theory

NARCIS (Netherlands)

Etienne, R.S.; Alonso, D.; McKane, A.J.

2007-01-01

The neutral theory of biodiversity as put forward by Hubbell in his 2001 monograph has received much criticism for its unrealistic simplifying assumptions. These are the assumptions of functional equivalence among different species (neutrality), the assumption of point mutation speciation, and the

Nearly Neutral Evolution Across the Drosophila melanogaster Genome

DEFF Research Database (Denmark)

Esteve, David Castellano; James, Jennifer; Eyre-Walker, Adam

2017-01-01

Under the nearly neutral theory of molecular evolution the proportion of effectively neutral mutations is expected to depend upon the effective population size (Ne). Here we investigate whether this is the case across the genome of Drosophila melanogaster using polymorphism data from 128 North...

Neutrino properties and neutral currents with their participation

International Nuclear Information System (INIS)

Tsukerman, I.S.

1979-01-01

Data on the neutrino properties and neutral current with their participation, published in 1977-78 are presented in the lecture. Experimental and cosmological limitations on mass, life time and neutrino oscillations are discussed. Heavy lepton properties and their relation to neutrino are considered. Neutral current data in neutrino-electron, neutrino-proton interactions and in anti νsub(μ)N interactions on nuclei are analyzed. Results of investigations of neutral currents in processes with π meson and strange particle production are given. The lecture material is based on the results presented at the last four international comferences on high energy physics

Policies and Initiatives for Carbon Neutrality in Nordic

DEFF Research Database (Denmark)

Wu, Qiuwei; Møller, Jakob Glarbo; Østergaard, Jacob

2013-01-01

Policies and initiatives promoting carbon neutrality in the Nordic heating and transport systems are presented. The focus within heating systems is the promotion of HPs (heat pumps) while the focus within transport systems is initiatives regarding EVs (electric vehicles). It is found...... for the future heating and transport systems with the ambition of realizing carbon neutrality...... that the conversion to HPs in the Nordic region relies on both private economic and national economic incentives. Initiatives toward carbon neutrality in the transport system are mostly concentrated on research, development and demonstration for deployment of a large number of EVs. All Nordic countries have plans...

Design and development of neutral beam module components

International Nuclear Information System (INIS)

Holl, P.M.; Bulmer, R.H.; Dilgard, L.W.; Horvath, J.A.; Molvik, A.W.; Porter, G.D.; Shearer, J.W.; Slack, D.S.; Colonias, J.S.

1979-01-01

The Mirror Fusion Test Facility (MFTF) injection system consists of twenty 20 keV start-up, and twenty-four 80 keV sustaining neutral beam source modules. The neutral beam modules are mounted in four clusters equally spaced around the waist of the vacuum vessel which contains the superconducting magnets. A module is defined here as an assembly consisting of a beam source and the interfacing components between that beam source and the vacuum chamber. Six major interfacing components are the subject of this paper. They are the magnetic shield, the neutralizer duct, the isolation valve, mounting gimbals, aiming bellows and actuators

Population growth enhances the mean fixation time of neutral mutations and the persistence of neutral variation.

Science.gov (United States)

Waxman, D

2012-06-01

A fundamental result of population genetics states that a new mutation, at an unlinked neutral locus in a randomly mating diploid population, has a mean time of fixation of ∼4N(e) generations, where N(e) is the effective population size. This result is based on an assumption of fixed population size, which does not universally hold in natural populations. Here, we analyze such neutral fixations in populations of changing size within the framework of the diffusion approximation. General expressions are derived for the mean and variance of the fixation time in changing populations. Some explicit results are given for two cases: (i) the effective population size undergoes a sudden change, representing a sudden population expansion or a sudden bottleneck; (ii) the effective population changes linearly for a limited period of time and then remains constant. Additionally, a lower bound for the mean time of fixation is obtained for an effective population size that increases with time, and this is applied to exponentially growing populations. The results obtained in this work show, among other things, that for populations that increase in size, the mean time of fixation can be enhanced, sometimes substantially so, over 4N(e,0) generations, where N(e,0) is the effective population size at the time the mutation arises. Such an enhancement is associated with (i) an increased probability of neutral polymorphism in a population and (ii) an enhanced persistence of high-frequency neutral variation, which is the variation most likely to be observed.

COMPARISON THEOREMS AND APPLICATIONS OF OSCILLATION OF NEUTRAL DIFFERENTIAL EQUATIONS

Institute of Scientific and Technical Information of China (English)

燕居让

1991-01-01

We first establish comparison theorems of the oscillation for a higher-order neutral delaydifferential equation. By these comparison theorems, the criterion of oscillation propertiesof neutral delay differential equation is reduced to that of nonneutral delay differential equa-tion, from which we give a series of oscillation theorems for neutral delay differentialequation.

Comparison of kinetic and fluid neutral models for attached and detached state

International Nuclear Information System (INIS)

Furubayashi, M.; Hoshino, K.; Toma, M.; Hatayama, A.; Coster, D.; Schneider, R.; Bonnin, X.; Kawashima, H.; Asakura, N.; Suzuki, Y.

2009-01-01

Neutral behavior has an important role in the transport simulations of the edge plasma. Most of the edge plasma transport codes treat neutral particles by a simple fluid model or a kinetic model. The fluid model allows faster calculations. However, the applicability of the fluid model is limited. In this study, simulation results of JT-60U from kinetic neutral model and fluid neutral model are compared under the attached and detached state, using the 2D edge plasma code package, SOLPS5.0. In the SOL region, no significant differences are observed in the upstream plasma profiles between kinetic and fluid neutral models. However, in the divertor region, large differences are observed in plasma and neutral profiles. Therefore, further optimization of the fluid neutral model should be performed. Otherwise kinetic neutral model should be used to analyze the divertor region.

Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein

International Nuclear Information System (INIS)

Bates, John T.; Keefer, Christopher J.; Slaughter, James C.; Kulp, Daniel W.; Schief, William R.; Crowe, James E.

2014-01-01

The role of binding kinetics in determining neutralizing potency for antiviral antibodies is poorly understood. While it is believed that increased steady-state affinity correlates positively with increased virus-neutralizing activity, the relationship between association or dissociation rate and neutralization potency is unclear. We investigated the effect of naturally-occurring antibody resistance mutations in the RSV F protein on the kinetics of binding to palivizumab. Escape from palivizumab-mediated neutralization of RSV occurred with reduced association rate (K on ) for binding to RSV F protein, while alteration of dissociation rate (K off ) did not significantly affect neutralizing activity. Interestingly, linkage of reduced K on with reduced potency mirrored the effect of increased K on found in a high-affinity enhanced potency palivizumab variant (motavizumab). These data suggest that association rate is the dominant factor driving neutralization potency for antibodies to RSV F protein antigenic site A and determines the potency of antibody somatic variants or efficiency of escape of viral glycoprotein variants. - Highlights: • The relationship of affinity to neutralization for virus antibodies is uncertain. • Palivizumab binds to RSV escape mutant fusion proteins, but with reduced affinity. • Association rate (K on ) correlated well with the potency of neutralization

Escape from neutralization by the respiratory syncytial virus-specific neutralizing monoclonal antibody palivizumab is driven by changes in on-rate of binding to the fusion protein

Energy Technology Data Exchange (ETDEWEB)

Bates, John T. [The Vanderbilt Vaccine Center, Departments of Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN (United States); Keefer, Christopher J. [The Vanderbilt Vaccine Center, Departments of Pediatrics, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN (United States); Slaughter, James C. [The Vanderbilt Vaccine Center, Departments of Biostatistics and Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN (United States); Kulp, Daniel W. [IAVI Neutralizing Antibody Center and Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA (United States); Schief, William R. [IAVI Neutralizing Antibody Center and Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA (United States); Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA (United States); Crowe, James E., E-mail: james.crowe@vanderbilt.edu [The Vanderbilt Vaccine Center, Departments of Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN (United States); The Vanderbilt Vaccine Center, Departments of Pediatrics, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN (United States)

2014-04-15

The role of binding kinetics in determining neutralizing potency for antiviral antibodies is poorly understood. While it is believed that increased steady-state affinity correlates positively with increased virus-neutralizing activity, the relationship between association or dissociation rate and neutralization potency is unclear. We investigated the effect of naturally-occurring antibody resistance mutations in the RSV F protein on the kinetics of binding to palivizumab. Escape from palivizumab-mediated neutralization of RSV occurred with reduced association rate (K{sub on}) for binding to RSV F protein, while alteration of dissociation rate (K{sub off}) did not significantly affect neutralizing activity. Interestingly, linkage of reduced K{sub on} with reduced potency mirrored the effect of increased K{sub on} found in a high-affinity enhanced potency palivizumab variant (motavizumab). These data suggest that association rate is the dominant factor driving neutralization potency for antibodies to RSV F protein antigenic site A and determines the potency of antibody somatic variants or efficiency of escape of viral glycoprotein variants. - Highlights: • The relationship of affinity to neutralization for virus antibodies is uncertain. • Palivizumab binds to RSV escape mutant fusion proteins, but with reduced affinity. • Association rate (K{sub on}) correlated well with the potency of neutralization.

TFTR neutral beam injection system conceptual design

International Nuclear Information System (INIS)

1975-01-01

Three subsystems are described in the following chapters: (1) Neutral Beam Injection Line; (2) Power Supplies; and (3) Controls. Each chapter contains two sections: (1) Functions and Design Requirements; this is a brief listing of the requirements of components of the subsystem. (2) Design Description; this section describes the design and cost estimates. The overall performance requirements of the neutral beam injection system are summarized. (MOW)

Hydrobiogeochemical interactions in 'anoxic' limestone drains for neutralization of acidic mine drainage

Science.gov (United States)

Robbins, E.I.; Cravotta, C.A.; Savela, C.E.; Nord, G.L.

1999-01-01

Processes affecting neutralization of acidic coal mine drainage were evaluated within 'anoxic' limestone drains (ALDs). Influents had pH???3.5 and dissolved oxygen Al3+ and Fe3+ compounds. Cleavage mounts of calcite and gypsum that were suspended within the ALDs and later examined microscopically showed dissolution features despite coatings by numerous bacteria, biofilms, and Fe-Al-Si precipitates. In the drain exhibiting the greatest flow reduction, Al-hydroxysulfates had accumulated on limestone surfaces and calcite etch points, thus causing the decline in transmissivity and dissolution. Therefore, where Al loadings are high and flow rates are low, a pre-treatment step is indicated to promote Al removal before diverting acidic mine water into alkalinity-producing materials. ?? 1998 Elsevier Science Ltd.

Modeling and experimental studies of the DIII-D neutral beam system

Energy Technology Data Exchange (ETDEWEB)

Crowley, B., E-mail: crowleyb@fusion.gat.com; Rauch, J.; Scoville, J.T.

2015-10-15

Highlights: • The issues surrounding proposals to increase neutral beam power are evaluated. • A tetrode version of the DIII-D ion source is modeled. • A neutralization efficiency of the DIII-D neutral beam is measured. • A power loading model of the neutral beam line is presented. - Abstract: In this paper, we present the results of beam physics experimental and modeling efforts aimed at learning from and building on the experience of the DIII-D off-axis neutral beam upgrade and other neutral beam system upgrades such as those at JET. The modeling effort includes electrostatic accelerator modeling (using a Poisson solver), gas dynamics modeling for the neutralizer and beam transport models for the beamline. Experimentally, spectroscopic and calorimetric techniques are used to evaluate the system performance. We seek to understand and ameliorate problems such as anomalous power deposition, originating from misdirected or excessively divergent beam particles, on a number of beamline components. We qualitatively and quantitatively evaluate possible project risks such as neutralization efficiency deficit and high voltage hold off associated with increasing the beam energy up to 105 keV.

Eosin Y photoredox catalyzed net redox neutral reaction for regiospecific annulation to 3-sulfonylindoles via anion oxidation of sodium sulfinate salts.

Science.gov (United States)

Rohokale, Rajendra S; Tambe, Shrikant D; Kshirsagar, Umesh A

2018-01-24

An eosin Y photoredox catalyzed net redox neutral process for 3-sulfonylindoles via the anionic oxidation of sodium sulfinate salts and its radical cascade cyclization with 2-alkynyl-azidoarenes was developed with visible light as a mediator. The reaction offers metal and oxidant/reductant free, visible light mediated vicinal sulfonamination of alkynes to 2-aryl/alkyl-3-sulfonylindoles and proceeds via the generation of a sulfur-centered radical through direct oxidation of the sulfinate anion by an excited photocatalyst with a reductive quenching cycle. The mild conditions, use of an organic dye as photo-catalyst, bench stability and easily accessible starting materials make the present approach green and attractive.

Real time neutral beam power control on MAST

Energy Technology Data Exchange (ETDEWEB)

Homfray, David A., E-mail: david.homfray@ccfe.ac.uk [EURATOM/CCFE Fusion Association, Culham Science Centre, Abingdon (United Kingdom); Benn, A.; Ciric, D.; Day, I.; Dunkley, V.; Keeling, D.; Khilar, S.; King, D.; King, R. [EURATOM/CCFE Fusion Association, Culham Science Centre, Abingdon (United Kingdom); Kurutz, U. [Department of Experimental Plasma Physics, University of Augsburg, Augsburg (Germany); Payne, D.; Simmonds, M.; Stevenson, P.; Tame, C. [EURATOM/CCFE Fusion Association, Culham Science Centre, Abingdon (United Kingdom)

2011-10-15

Real time power control of neutral beam provides an excellent tool for many different plasma physics studies. Power control at a better resolution than the level of a single injector is usually achieved by modulating individual power supplies. However, the short beam slowing down time on MAST is such that the plasma would be sensitive to modulating the neutral beam using this 100% on-off pulse-width modulation method. A novel alternative method of power control has been demonstrated, where the arc current, and hence beam current, has been controlled in real time allowing variations in neutral beam power. This has been demonstrated in a MAST plasma with almost no loss of transmission as a consequence of the optical properties of the high perveance MAST neutral beam system. This paper will detail the methodology, experiment and results and discuss the full implementation of this method that will allow MAST to control the beam power in real time.

Identification of neutral tumor evolution across cancer types

Science.gov (United States)

Barnes, Chris P; Graham, Trevor A; Sottoriva, Andrea

2016-01-01

Despite extraordinary efforts to profile cancer genomes, interpreting the vast amount of genomic data in the light of cancer evolution remains challenging. Here we demonstrate that neutral tumor evolution results in a power-law distribution of the mutant allele frequencies reported by next-generation sequencing of tumor bulk samples. We find that the neutral power-law fits with high precision 323 of 904 cancers from 14 types, selected from different cohorts. In malignancies identified as neutral, all clonal selection occurred prior to the onset of cancer growth and not in later-arising subclones, resulting in numerous passenger mutations that are responsible for intra-tumor heterogeneity. Reanalyzing cancer sequencing data within the neutral framework allowed the measurement, in each patient, of both the in vivo mutation rate and the order and timing of mutations. This result provides a new way to interpret existing cancer genomic data and to discriminate between functional and non-functional intra-tumor heterogeneity. PMID:26780609

C-X neutral spectra from ZT-40M

International Nuclear Information System (INIS)

Munson, C.; Carolan, P.G.; Bunting, C.A.

1988-01-01

A series of experiments have recently been completed on the ZT-40M Reversed Field Pinch at Los Alamos for which Neutral Charge Exchange (C-X) spectra have been measured using both the previously reported Time-of-Flight (TOF) system, and a 5 channel electrostatic Neutral Particle Analyzer (NPA). The experiments involved measurements of ion and electron temperatures for a variety of discharge conditions including scans of flat-top current levels, different values of the toroidal field reversal parameter (F = B phi (a)/ phi >), ramped current discharges, discharges with a movable graphite paddle limiter inserted into the edge of the plasma from above, and discharges with Deuterium pellet injection. Both the TOF and NPA systems view the plasma along chords from the outside midplane, and are separated by 60 0 toroidally. Core ion temperatures are obtained by examining the asymptotic tail of the neutral particle efflux spectrum. Detailed comparisons of the neutral particle spectra obtained with these two systems for the various operating conditions will be presented

Three-dimensional calculations of charge neutralization by neutral gas release

International Nuclear Information System (INIS)

Mandell, M.J.; Jongeward, G.A.; Katz, I.

1993-01-01

There have been numerous observations of high rocket or spacecraft potentials, both positive and negative, and both naturally and artificially induced, being neutralized during thruster firings. Two current studies, CHARGE-2B (positive polarity) and SPEAR3 (negative polarity), attempt a more systematic exploration of this phenomenon. The authors present here calculations performed in support of the SPEAR-3 program. (1) Conventional phenomenology of breakdown is applied to the three-dimensional system formed by the electrostatic potential and plume density fields. Using real cross sections, they calculate the paths along which the nozzle plume can support breakdown. This leads to a recommendation that the higher flow rate on SPEAR-3 be 2 g/s of argon, equal to the CHARGE-2B flow rate. (2) In a laboratory chamber, conditions (pressure of ∼ 2 x 10 - 5 torr) favor breakdown of the positive (electron-collecting) sheath for SPEAR-3 geometry. Three-dimensional calculations illustrate the evolution of the space charge and potential structure during the breakdown process. These calculations demonstrate the ability to apply accepted phenomenology to real systems with three dimensional electrostatic potential fields, space charge fields, and neutral density fields, including magnetic field effects and real cross-section data

Extinction in neutrally stable stochastic Lotka-Volterra models

Science.gov (United States)

Dobrinevski, Alexander; Frey, Erwin

2012-05-01

Populations of competing biological species exhibit a fascinating interplay between the nonlinear dynamics of evolutionary selection forces and random fluctuations arising from the stochastic nature of the interactions. The processes leading to extinction of species, whose understanding is a key component in the study of evolution and biodiversity, are influenced by both of these factors. Here, we investigate a class of stochastic population dynamics models based on generalized Lotka-Volterra systems. In the case of neutral stability of the underlying deterministic model, the impact of intrinsic noise on the survival of species is dramatic: It destroys coexistence of interacting species on a time scale proportional to the population size. We introduce a new method based on stochastic averaging which allows one to understand this extinction process quantitatively by reduction to a lower-dimensional effective dynamics. This is performed analytically for two highly symmetrical models and can be generalized numerically to more complex situations. The extinction probability distributions and other quantities of interest we obtain show excellent agreement with simulations.

Greenhouse gas neutral Germany in 2050

International Nuclear Information System (INIS)

Benndorf, Rosemarie; Bernicke, Maja; Bertram, Andreas

2014-01-01

In order to answer the question how a greenhouse gas neutral Germany would look like an interdisciplinary process was started by the Federal Environmental Agency. It was clear from the beginning of this work that a sustainable regenerative energy supply could not be sufficient. Therefore all relevant emission sources were included into the studies: traffic, industry, waste and waste water, agriculture, land usage, land usage changes and forestry. The necessary transformation paths to reach the aim of a greenhouse gas neutral Germany in 2050, economic considerations and political instruments were not part of this study.

Neutral beam injection in 2XIIB

International Nuclear Information System (INIS)

Hibbs, S.M.

1975-01-01

Integrated into the operation of the 2XIIB controlled fusion experiment is a 600-A, 20-keV neutral injection system: the highest neutral-beam current capacity of any existing fusion machine. This paper outlines the requirements of the injection system and the design features to which they led. Both mechanical and electrical aspects are discussed. Also included is a brief description of some operational aspects of the system and some of the things we have learned along the way, as well as a short history of the most significant developments

The net neutrality debate on Twitter

Directory of Open Access Journals (Sweden)

Wolf J. Schünemann

2015-12-01

Full Text Available The internet has been seen as a medium that empowers individual political actors in relation to established political elites and media gatekeepers. The present article discusses this “net empowerment hypothesis” and tests it empirically by analysing Twitter communication on the regulation of net neutrality. We extracted 503.839 tweets containing #NetNeutrality posted between January and March 2015 and analysed central developments and the network structure of the debate. The empirical results show that traditional actors from media and politics still maintain a central role.

Neutral particle transport modeling with a reflective source in the plasma edge

International Nuclear Information System (INIS)

Valenti, M.E.

1992-01-01

A reflective source term is incorporated into the Boltzmann neutral particle transport equation to account for boundary reflection. This reflective neutral model is integrated over a uniform axis and subsequently discretized. The discrete two-dimensional equations are solved iteratively with a computer code. The results of the reflective neutral model computer code are benchmarked with the neutral particle transport code ONEDANT. The benchmark process demonstrates the validity of the reflective neutral model. The reflective neutral model is coupled to the Braams plasma particle and energy transport code. The coupled system generates self-consistent plasma edge transport solutions. These solutions, which utilize the transport equation are similar to solutions which utilize simple plasma edge neutral models when high recycle divertors are modeled. In the high recycle mode, the high electron density at the divertor plate reduces the mean free path of plate neutrals. Hence, the similarity in results. It is concluded that simple neutral models are sufficient for the analysis of high recycle power reactor edge plasmas. Low recycle edge plasmas were not examined

MAVEN Pickup Ion Constraints on Mars Neutral Escape

Science.gov (United States)

Rahmati, A.; Larson, D. E.; Cravens, T.; Lillis, R. J.; Dunn, P.; Halekas, J. S.; McFadden, J. P.; Mitchell, D. L.; Thiemann, E.; Connerney, J. E. P.; DiBraccio, G. A.; Espley, J. R.; Eparvier, F. G.

2017-12-01

Mars is currently losing its atmosphere mainly due to the escape of neutral hydrogen and oxygen. Directly measuring the rate of escaping neutrals is difficult, because the neutral density in the Mars exosphere is dominated, up to several Martian radii, by atoms that are gravitationally bound to the planet. Neutral atoms in the Martian exosphere, however, can get ionized, picked up, and accelerated by the solar wind motional electric field and energized to energies high enough for particle detectors to measure them. The MAVEN SEP instrument detects O+ pickup ions that are created at altitudes where the escaping part of the exosphere is dominant. Fluxes of these ions reflect neutral densities in the distant exosphere of Mars, allowing us to constrain neutral oxygen escape rates. The MAVEN SWIA and STATIC instruments measure pickup H+ and O+ created closer to Mars; comparisons of these data with models can be used to constrain exospheric hot O and thermal H densities and escape rates. In this work, pickup ion measurements from SEP, SWIA, and STATIC, taken during the first 3 Earth years of the MAVEN mission, are compared to the outputs of a pickup ion model to constrain the variability of neutral escape at Mars. The model is based on data from six MAVEN instruments, namely, MAG providing magnetic field used in calculating pickup ion trajectories, SWIA providing solar wind velocity as well as 3D pickup H+ and O+ spectra, SWEA providing solar wind electron spectrum used in electron impact ionization rate calculations, SEP providing pickup O+ spectra, STATIC providing mass resolved 3D pickup H+ and O+ spectra, and EUVM providing solar EUV spectra used in photoionization rate calculations. A variability of less than a factor of two is observed in hot oxygen escape rates, whereas thermal escape of hydrogen varies by an order of magnitude with Mars season. This hydrogen escape variability challenges our understanding of the H cycle at Mars, but is consistent with other

Emotional and neutral scenes in competition: orienting, efficiency, and identification.

Science.gov (United States)

Calvo, Manuel G; Nummenmaa, Lauri; Hyönä, Jukka

2007-12-01

To investigate preferential processing of emotional scenes competing for limited attentional resources with neutral scenes, prime pictures were presented briefly (450 ms), peripherally (5.2 degrees away from fixation), and simultaneously (one emotional and one neutral scene) versus singly. Primes were followed by a mask and a probe for recognition. Hit rate was higher for emotional than for neutral scenes in the dual- but not in the single-prime condition, and A' sensitivity decreased for neutral but not for emotional scenes in the dual-prime condition. This preferential processing involved both selective orienting and efficient encoding, as revealed, respectively, by a higher probability of first fixation on--and shorter saccade latencies to--emotional scenes and by shorter fixation time needed to accurately identify emotional scenes, in comparison with neutral scenes.

Multigroup calculations of low-energy neutral transport in tokamak plasmas

International Nuclear Information System (INIS)

Gilligan, J.G.; Gralnick, S.L.; Price, W.G. Jr.; Kammash, T.

1978-01-01

Multigroup discrete ordinates methods avoid many of the approximations that have been used in previous neutral transport analyses. Of particular interest are the neutral profiles generated as an integral part of larger plasma system simulation codes. To determine the appropriateness of utilizing a particular multigroup code, ANISN, for this purpose, results are compared with the neutral transport module of the Duechs code. For a typical TFTR plasma, predicted neutral densities differ by a maximum factor of three on axis and outfluxes at the plasma boundary by approximately 40%. This is found to be significant for a neutral transport module. Possible sources of the observed discrepancies are indicated from an analysis of the approximations used in the Duechs model. Recommendations are made concerning the future application of the multigroup method. (author)

CFD Modeling of Non-Neutral Atmospheric Boundary Layer Conditions

DEFF Research Database (Denmark)

Koblitz, Tilman

model results. A method is developed how to simulate the time-dependant non-neutral ABL flow over complex terrain: a precursor simulation is used to specify unsteady inlet boundary conditions on complex terrain domains. The advantage of the developed RANS model framework is its general applicability...... characteristics of neutral and non-neutral ABL flow. The developed ABL model significantly improves the predicted flow fields over both flat and complex terrain, when compared against neutral models and measurements....... cost than e.g. using large-eddy simulations. The developed ABL model is successfully validated using a range of different test cases with increasing complexity. Data from several large scale field campaigns, wind tunnel experiments, and previous numerical simulations is presented and compared against...

Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection.

Directory of Open Access Journals (Sweden)

Gene S Tan

2016-04-01

Full Text Available In the early spring of 2013, Chinese health authorities reported several cases of H7N9 influenza virus infections in humans. Since then the virus has established itself at the human-animal interface in Eastern China and continues to cause several hundred infections annually. In order to characterize the antibody response to the H7N9 virus we generated several mouse monoclonal antibodies against the hemagglutinin of the A/Shanghai/1/13 (H7N9 virus. Of particular note are two monoclonal antibodies, 1B2 and 1H5, that show broad reactivity to divergent H7 hemagglutinins. Monoclonal antibody 1B2 binds to viruses of the Eurasian and North American H7 lineages and monoclonal antibody 1H5 reacts broadly to virus isolates of the Eurasian lineage. Interestingly, 1B2 shows broad hemagglutination inhibiting and neutralizing activity, while 1H5 fails to inhibit hemagglutination and demonstrates no neutralizing activity in vitro. However, both monoclonal antibodies were highly protective in an in vivo passive transfer challenge model in mice, even at low doses. Experiments using mutant antibodies that lack the ability for Fc/Fc-receptor and Fc/complement interactions suggest that the protection provided by mAb 1H5 is, at least in part, mediated by the Fc-fragment of the mAb. These findings highlight that a protective response to a pathogen may not only be due to neutralizing antibodies, but can also be the result of highly efficacious non-neutralizing antibodies not readily detected by classical in vitro neutralization or hemagglutination inhibition assays. This is of interest because H7 influenza virus vaccines induce only low hemagglutination inhibiting antibody titers while eliciting robust antibody titers as measured by ELISA. Our data suggest that these binding but non-neutralizing antibodies contribute to protection in vivo.

Electrochemical reduction of imazamethabenz methyl on mercury and carbon electrodes

International Nuclear Information System (INIS)

Ruiz Montoya, Mercedes; Pintado, Sara; Rodriguez Mellado, Jose Miguel

2010-01-01

This paper presents polarographic and voltammetric studies of the reduction of the herbicide imazamethabenz methyl (2/3-methyl-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-p-toluate), on mercury and carbon electrodes. The electrochemical studies were performed in strongly acidic media (0.1-2.7 M H 2 SO 4 ) as well as in the pH range of 1-12. The overall reduction process involves the uptake of two electrons. The results obtained in polarography show that there is the reduction of two species, related via an acid-base equilibrium, and having very close reduction potentials. The voltammetric results obtained with a glassy carbon electrode were very similar to those observed on mercury electrodes. The reducible group in the molecule is the imidazolinone ring. In strongly acidic media (pH a ), the reaction mechanism proposed is the reduction of the protonated herbicide by an electrochemical-chemical-electrochemical (ECE) process, being the r.d.s. the second electron transfer. At pH > pK a the neutral form of the herbicide is reduced and the second electron transfer becomes reversible or quasi-reversible. In basic media, the species reduced is the deprotonated imazamethabenz methyl and the r.d.s. is the second electron transfer.

Electrochemical reduction of imazamethabenz methyl on mercury and carbon electrodes

Energy Technology Data Exchange (ETDEWEB)

Ruiz Montoya, Mercedes, E-mail: mmontoya@uhu.e [Departamento de Ingenieria Quimica, Quimica Fisica y Quimica Organica, Universidad de Huelva, Campus El Carmen, Facultad de Ciencias Experimentales, E-21071 Huelva (Spain); Pintado, Sara; Rodriguez Mellado, Jose Miguel [Departamento de Quimica Fisica y Termodinamica Aplicada, Universidad de Cordoba, Campus Universitario de Rabanales, edificio ' Marie Curie' , E-14014 Cordoba (Spain)

2010-03-30

This paper presents polarographic and voltammetric studies of the reduction of the herbicide imazamethabenz methyl (2/3-methyl-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-p-toluate), on mercury and carbon electrodes. The electrochemical studies were performed in strongly acidic media (0.1-2.7 M H{sub 2}SO{sub 4}) as well as in the pH range of 1-12. The overall reduction process involves the uptake of two electrons. The results obtained in polarography show that there is the reduction of two species, related via an acid-base equilibrium, and having very close reduction potentials. The voltammetric results obtained with a glassy carbon electrode were very similar to those observed on mercury electrodes. The reducible group in the molecule is the imidazolinone ring. In strongly acidic media (pH < pK{sub a}), the reaction mechanism proposed is the reduction of the protonated herbicide by an electrochemical-chemical-electrochemical (ECE) process, being the r.d.s. the second electron transfer. At pH > pK{sub a} the neutral form of the herbicide is reduced and the second electron transfer becomes reversible or quasi-reversible. In basic media, the species reduced is the deprotonated imazamethabenz methyl and the r.d.s. is the second electron transfer.

LADEE Neutral Mass Spectrometer Data

Data.gov (United States)

National Aeronautics and Space Administration — This bundle contains the data collected by the Neutral Mass Spectrometer (NMS) instrument aboard the Lunar Atmosphere and Dust Environment Explorer (LADEE)...

Characterization of human monoclonal antibodies that neutralize multiple poliovirus serotypes.

Science.gov (United States)

Puligedda, Rama Devudu; Kouiavskaia, Diana; Al-Saleem, Fetweh H; Kattala, Chandana Devi; Nabi, Usman; Yaqoob, Hamid; Bhagavathula, V Sandeep; Sharma, Rashmi; Chumakov, Konstantin; Dessain, Scott K

2017-10-04

Following the eradication of wild poliovirus (PV), achieving and maintaining a polio-free status will require eliminating potentially pathogenic PV strains derived from the oral attenuated vaccine. For this purpose, a combination of non-cross-resistant drugs, such as small molecules and neutralizing monoclonal antibodies (mAbs), may be ideal. We previously isolated chimpanzee and human mAbs capable of neutralizing multiple PV types (cross-neutralization). Here, we describe three additional human mAbs that neutralize types 1 and 2 PV and one mAb that neutralizes all three types. Most bind conformational epitopes and have unusually long heavy chain complementarity determining 3 domains (HC CDR3). We assessed the ability of the mAbs to neutralize A12 escape mutant PV strains, and found that the neutralizing activities of the mAbs were disrupted by different amino acid substitutions. Competitive binding studies further suggested that the specific mAb:PV interactions that enable cross-neutralization differ among mAbs and serotypes. All of the cloned mAbs bind PV in the vicinity of the "canyon", a circular depression around the 5-fold axis of symmetry through which PV recognizes its cellular receptor. We were unable to generate escape mutants to two of the mAbs, suggesting that their epitopes are important for the PV life cycle. These data indicate that PV cross-neutralization involves binding to highly conserved structures within the canyon that binds to the cellular receptor. These may be facilitated by the long HC CDR3 domains, which may adopt alternative binding configurations. We propose that the human and chimpanzee mAbs described here could have potential as anti-PV therapeutics. Copyright © 2017 Elsevier Ltd. All rights reserved.

Report on neutral particle detectors and QED: PEP summer study

International Nuclear Information System (INIS)

Bloom, E.D.; Bulos, F.; Buschhorn, G.

1974-08-01

The exploration of the neutral particle final states in e + e/sup /minus// annihilation using a 4π neutral particle detector is discussed. Charge particle final state physics is also considered in the context of a neutral detector. Design criteria are discussed, and a possible detector design is presented. 15 refs., 13 figs., 2 tabs

Manufacturing of neutral beam sources at Lawrence Livermore Laboratory

International Nuclear Information System (INIS)

Baird, E.D.; Duffy, T.J.; Harter, G.A.; Holland, E.D.; Kloos, W.A.; Pastrone, J.A.

1979-01-01

Over 50 neutral beam sources (NBS) of the joint Lawrence Berkeley Laboratory (LBL)/Lawrence Livermore Laboratory (LLL) design have been manufactured, since 1973, in the LLL Neutral Beam Source Facility. These sources have been used to provide start-up and sustaining neutral beams for LLL mirror fusion experiments, including 2XIIB, TMX, and Beta II. Experimental prototype 20-kV and 80-kV NBS have also been designed, built, and tested for the Mirror Fusion Test Facility (MFTF)

High-beta experiments with neutral-beam injection on PDX

International Nuclear Information System (INIS)

Johnson, D.; Bell, M.; Bitter, M.

1983-01-01

Experimental investigations of high-beta plasmas produced in PDX with near-perpendicular neutral-beam injection are reported. Systematic power scans have been performed over a wide range of toroidal fields (νsub(T)q.7 T< Bsub(T)<2.2 T) and plasma currents (200 kA< Isub(p)<500 kA). At high toroidal fields, the change in total stored energy due to beam injection increases linearly with input power and also increases with plasma current. At lower toroidal fields and low injection power levels, the stored energy also increases with power and plasma current. However, at high power and low toroidal fields, a saturation in heating is observed. This result suggests the onset of a νsub(T) limit for circular cross-section tokamaks with near-perpendicular injection. Scaling experiments indicate that this νsub(T) limit increases with rising 1/q. Values of νsub(T)approx.=3% at qsub(PSI)=1.8 have been achieved. At high values of νsub(T)q, short bursts of MHD activity are observed, synchronized with sharply increased fluxes of perpendicular charge-exchange neutrals and rapid decreases in the rate of beam-driven neutron production. When strong bursts occur, there is a significant depletion of the fast-ion population. Estimates of the fast-ion loss indicate that it could explain the observed decrease in heating, although an additional reduction in thermal-plasma confinement cannot be ruled out. Numerical studies using measured pressure profiles predict that the equilibria obtained become unstable to the ideal n=1 internal mode, at about the same value of 0 where the new fluctuations are observed. (author)

Status of HEP neutral net research in the USA

International Nuclear Information System (INIS)

Denby, B.; Linn, S.L.

1989-01-01

Progress on tracking with recurrent neutral networks is presented. Applications of feed-forward networks to high energy physics are discussed. The situation regarding hardware implementations of neutral networks is assessed. (orig.)

Adaptive evolutionary walks require neutral intermediates in RNA fitness landscapes.

Science.gov (United States)

Rendel, Mark D

2011-01-01

In RNA fitness landscapes with interconnected networks of neutral mutations, neutral precursor mutations can play an important role in facilitating the accessibility of epistatic adaptive mutant combinations. I use an exhaustively surveyed fitness landscape model based on short sequence RNA genotypes (and their secondary structure phenotypes) to calculate the minimum rate at which mutants initially appearing as neutral are incorporated into an adaptive evolutionary walk. I show first, that incorporating neutral mutations significantly increases the number of point mutations in a given evolutionary walk when compared to estimates from previous adaptive walk models. Second, that incorporating neutral mutants into such a walk significantly increases the final fitness encountered on that walk - indeed evolutionary walks including neutral steps often reach the global optimum in this model. Third, and perhaps most importantly, evolutionary paths of this kind are often extremely winding in their nature and have the potential to undergo multiple mutations at a given sequence position within a single walk; the potential of these winding paths to mislead phylogenetic reconstruction is briefly considered. Copyright © 2010 Elsevier Inc. All rights reserved.

Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity.

Science.gov (United States)

Feng, Ying; Sun, Xikui; Ye, Xianmiao; Feng, Yupeng; Wang, Jinlin; Zheng, Xuehua; Liu, Xinglong; Yi, Changhua; Hao, Mingli; Wang, Qian; Li, Feng; Xu, Wei; Li, Liang; Li, Chufang; Zhou, Rong; Chen, Ling; Feng, Liqiang

2018-05-01

Re-emerging human adenoviruses type 14 (HAdV14) and 55 (HAdV55) represent two highly virulent adenoviruses. The neutralizing antibody (nAb) responses elicited by infection or immunization remain largely unknown. Herein, we generated hexon-chimeric HAdV14 viruses harboring each single or entire hexon hyper-variable-regions (HVR) from HAdV55, and determined the neutralizing epitopes of human and mouse nAbs. In human sera, hexon-targeting nAbs are type-specific and mainly recognize HVR2, 5, and 7. Fiber-targeting nAbs are only detectable in sera cross-neutralizing HAdV14 and HAdV55 and contribute substantially to cross-neutralization. Penton-binding antibodies, however, show no significant neutralizing activities. In mice immunized with HAdV14 or HAdV55, a single immunization mainly elicited hexon-specific nAbs, which recognized HAdV14 HVR1, 2, and 7 and HAdV55 HVR1 and 2, respectively. After a booster immunization, cross-neutralizing fiber-specific nAbs became detectable. These results indicated that hexon elicits type-specific nAbs whereas fiber induces cross-neutralizing nAbs to HAdV14 and HAdV55, which are of significance in vaccine development. Copyright © 2018 Elsevier Inc. All rights reserved.

Trapping neutral molecules in a traveling potential well

NARCIS (Netherlands)

Bethlem, H. L.; G. Berden,; van Roij, A. J. A.; Crompvoets, F. M. H.; Meijer, G.

2000-01-01

A series of pulsed electric fields can be arranged such that it creates a traveling potential well in which neutral dipolar molecules can be confined. This provides a method to transport, to decelerate, and to cool a sample of neutral molecules while maintaining the initial phase-space density. This

Neutral injection experiments on the ISX-B tokamak

International Nuclear Information System (INIS)

Scott, S.D.

1983-01-01

The following topics are described: (1) review of confinement scaling in ISX-B with strong neutral injection in clean plasmas, (2) discussion of observed energy confinement improvement in slightly contaminated discharges (factor less than or equal to 2), and (3) preliminary evaluation of confinement with balanced neutral beam injection

Material failures observed in the Doublet III neutral beamlines

International Nuclear Information System (INIS)

Bailey, E.W.; Colleraine, A.; Doll, D.; Grunloh, H.; Kim, J.; Langhorn, A.; Thurgood, B.

1983-01-01

The Doublet III neutral beam injectors consist of three separable spools two meters in diameter by four meters long overall when assembled. Contained within these spools are the neutralizers, ion dumps, deflecting magnet, calorimeter dumps, cryogenic panels and beam scraping collimators. To date three beamlines are in operation on Doublet III, and the beams have accumulated operating time of approximately 32 months, with the oldest having been in operation for 18 months. During this time operation of DIII with the neutral beam sources has demonstrated the following: 7.8 MW injected neutrals from three beamlines (6 sources), high β (4.5%), and non-circular plasma shape. The sources have also exibited a very reliable injected shot history. Material failures encountered during the operation of DIII N.B. injectors and the solutions to these failures are described. Failures include cracking of the neutralizer exit collimator due to heating cycles, failure of cyropanel support rods due to cooling cycles, failure of the sliding drive of the moveable calorimeter due to friction

Antihypertensive neutral lipid

Science.gov (United States)

Snyder, F.L.; Blank, M.L.

1984-10-26

The invention relates to the discovery of a class of neutral acetylated either-linked glycerolipids having the capacity to lower blood presure in warm-blooded animals. This physiological effect is structure sensitive requiring a long chain alkyl group at the sn-1 position and a short carbon chain acyl group (acetyl or propionyl) at the sn-2 position, and a hydroxyl group at the sn-3 position.

Applications of neutral beam and rf technologies

International Nuclear Information System (INIS)

Haselton, H.H.

1987-04-01

This presentation provides an update on the applications of neutral beams and radiofrequency (rf) power in the fusion program; highlights of the ion cyclotron heating (ICH) experiments now in progress, as well as the neutral beam experiments; and heating requirements of future devices and some of the available options. Some remarks on current drive are presented because this area of technology is one that is being considered for future devices

Asymmetry in species regional dispersal ability and the neutral theory.

Directory of Open Access Journals (Sweden)

Jiajia Liu

Full Text Available The neutral assumption that individuals of either the same or different species share exactly the same birth, death, migration, and speciation probabilities is fundamental yet controversial to the neutral theory. Several theoretical studies have demonstrated that a slight difference in species per capita birth or death rates can have a profound consequence on species coexistence and community structure. Whether asymmetry in migration, a vital demographic parameter in the neutral model, plays an important role in community assembly still remains unknown. In this paper, we relaxed the ecological equivalence assumption of the neutral model by introducing differences into species regional dispersal ability. We investigated the effect of asymmetric dispersal on the neutral local community structure. We found that per capita asymmetric dispersal among species could reduce species richness of the local community and result in deviations of species abundance distributions from those predicted by the neutral model. But the effect was moderate compared with that of asymmetries in birth or death rates, unless very large asymmetries in dispersal were assumed. A large difference in species dispersal ability, if there is, can overwhelm the role of random drift and make local community dynamics deterministic. In this case, species with higher regional dispersal abilities tended to dominate in the local community. However, the species abundance distribution of the local community under asymmetric dispersal could be well fitted by the neutral model, but the neutral model generally underestimated the fundamental biodiversity number but overestimated the migration rate in such communities.

Neutral-beam performance analysis using a CCD camera

International Nuclear Information System (INIS)

Hill, D.N.; Allen, S.L.; Pincosy, P.A.

1986-01-01

We have developed an optical diagnostic system suitable for characterizing the performance of energetic neutral beams. An absolutely calibrated CCD video camera is used to view the neutral beam as it passes through a relatively high pressure (10 -5 Torr) region outside the neutralizer: collisional excitation of the fast deuterium atoms produces H/sub proportional to/ emission (lambda = 6561A) that is proportional to the local atomic current density, independent of the species mix of accelerated ions over the energy range 5 to 20 keV. Digital processing of the video signal provides profile and aiming information for beam optimization. 6 refs., 3 figs

Neutral meson production in $p$-Be and $p$-Au collisions at 450 GeV beam energy

CERN Document Server

Agakichiev, G; Averbeck, R; Ballester, F; Baur, R; Brenschede, A; Díaz, J; Drees, A; Faschingbauer, U; Ferrero, J L; Fischer, P; Fraenkel, Zeev; Franke, M; Fuchs, C; Gatti, E; Glässel, P; Günzel, T F; Pérez de los Heros, C; Hess, F; Holzmann, R; Irmscher, D; Jacob, C; Kühn, W; Lenkeit, B C; Löhner, H; Marin, A; Marqués, F M; Martínez, G; Metag, V; Notheisen, M; Novotny, R; Olsen, L H; Ostendorf, R W; Panebratsev, Yu A; Pfeiffer, A; Ravinovich, I; Rehak, P; Sampietro, M; Schön, A; Schükraft, Jürgen; Schutz, Y; Shimansky, S S; Shor, A; Simon, R S; Specht, H J; Steiner, V; Tapprogge, Stefan; Tel-Zur, G; Tserruya, Itzhak; Ullrich, T S; Wilschut, H W; Wurm, J P; Yurevich, V I

1998-01-01

In a joint experiment the TAPS and CERES collaborations have studied the production of the neutral mesons $\\pi^{0}$, $\\eta$ and $\\omega$ in 450 GeV $p$-Be and $p$-Au collisions at the CERN SPS. The mesons were identified by their $\\pi^{0} \\rightarrow \\gamma\\gamma, \\eta \\rightarrow \\gamma\\gamma$, and $\\omega \\rightarrow \\pi^{0}\\gamma$ decay modes. The cross sections were measured down to very low $p_{T}$ ($\\geq$ 20 MeV/c) near mid-rapidity $(3.0reduction may be attributed to the large number of low $p_{T}$ pions from decays of heavier mesons. In addition, we have studied the dependence of neutral meson production on the mass of the nuclear target and find it in good agreement with previous measurements of charged mesons.

Near neutrality: leading edge of the neutral theory of molecular evolution.

Science.gov (United States)

Hughes, Austin L

2008-01-01

The nearly neutral theory represents a development of Kimura's neutral theory of molecular evolution that makes testable predictions that go beyond a mere null model. Recent evidence has strongly supported several of these predictions, including the prediction that slightly deleterious variants will accumulate in a species that has undergone a severe bottleneck or in cases where recombination is reduced or absent. Because bottlenecks often occur in speciation and slightly deleterious mutations in coding regions will usually be nonsynonymous, we should expect that the ratio of nonsynonymous to synonymous fixed differences between species should often exceed the ratio of nonsynonymous to synonymous polymorphisms within species. Many data support this prediction, although they have often been wrongly interpreted as evidence for positive Darwinian selection. The use of conceptually flawed tests for positive selection has become widespread in recent years, seriously harming the quest for an understanding of genome evolution. When properly analyzed, many (probably most) claimed cases of positive selection will turn out to involve the fixation of slightly deleterious mutations by genetic drift in bottlenecked populations. Slightly deleterious variants are a transient feature of evolution in the long term, but they have substantially affected contemporary species, including our own.

Effects of stream topology on ecological community results from neutral models

Science.gov (United States)

While neutral theory and models have stimulated considerable literature, less well investigated is the effect of topology on neutral metacommunity model simulations. We implemented a neutral metacommunity model using two different stream network topologies, a widely branched netw...

Five second helium neutral beam injection using argon-frost cryopumping techniques

International Nuclear Information System (INIS)

Phillips, J.C.; Kellman, D.H.; Hong, R.; Kim, J.; Laughon, G.M.

1995-01-01

High power helium neutral beams for the heating of tokamak discharges can now be provided for 5 s by using argon cryopumping (of the helium gas) in the beamlines. The DIII-D neutral beam system has routinely provided up to 20 MW of deuterium neutral beam heating in support of experiments on the DIII-D tokamak. Operation of neutral beams with helium has historically presented a problem in that pulse lengths have been limited to 500 ms due to reliance solely on volume pumping of the helium gas. Helium is not condensed on the cryopanels. A system has now been installed to deposit a layer of argon frost on the DIII-D neutral beam cryopanels, between tokamak injection pulses. The layer serves to trap helium on the cryopanels providing sufficient pumping speed for 5 s helium beam extraction. The argon frosting hardware is now present on two of four DIII-D neutral beamlines, allowing injection of up to 6 MW of helium neutral beams per discharge, with pulse lengths of up to 5 s. The argon frosting system is described, along with experimental results demonstrating its effectiveness as a method of economically extending the capabilities of cryogenic pumping panels to allow multi-second helium neutral beam injection

Effect of Thermospheric Neutral Density upon Inner Trapped-belt Proton Flux

Science.gov (United States)

Wilson, Thomas L.; Lodhi, M. A. K.; Diaz, Abel B.

2007-01-01

We wish to point out that a secular change in the Earth's atmospheric neutral density alters charged-particle lifetime in the inner trapped radiation belts, in addition to the changes recently reported as produced by greenhouse gases. Heretofore, changes in neutral density have been of interest primarily because of their effect on the orbital drag of satellites. We extend this to include the orbital lifetime of charged particles in the lower radiation belts. It is known that the charged-belt population is coupled to the neutral density of the atmosphere through changes induced by solar activity, an effect produced by multiple scattering off neutral and ionized atoms along with ionization loss in the thermosphere where charged and neutral populations interact. It will be shown here that trapped-belt flux J is bivariant in energy E and thermospheric neutral density , as J(E,rho). One can conclude that proton lifetimes in these belts are also directly affected by secular changes in the neutral species populating the Earth s thermosphere. This result is a consequence of an intrinsic property of charged-particle flux, that flux is not merely a function of E but is dependent upon density rho when a background of neutrals is present.

Characterizing Peptide Neutral Losses Induced by Negative Electron-Transfer Dissociation (NETD)

Science.gov (United States)

Rumachik, Neil G.; McAlister, Graeme C.; Russell, Jason D.; Bailey, Derek J.; Wenger, Craig D.; Coon, Joshua J.

2012-01-01

We implemented negative electron-transfer dissociation (NETD) on a hybrid ion trap/Orbitrap mass spectrometer to conduct ion/ion reactions using peptide anions and radical reagent cations. In addition to sequence-informative ladders of a•- and x-type fragment ions, NETD generated intense neutral loss peaks corresponding to the entire or partial side-chain cleavage from amino acids constituting a given peptide. Thus, a critical step towards the characterization of this recently introduced fragmentation technique is a systematic study of synthetic peptides to identify common neutral losses and preferential fragmentation pathways. Examining 46 synthetic peptides with high mass accuracy and high resolution analysis permitted facile determination of the chemical composition of each neutral loss. We identified 19 unique neutral losses from 14 amino acids and three modified amino acids, and assessed the specificity and sensitivity of each neutral loss using a database of 1542 confidently identified peptides generated from NETD shotgun experiments employing high-pH separations and negative electrospray ionization. As residue-specific neutral losses indicate the presence of certain amino acids, we determined that many neutral losses have potential diagnostic utility. We envision this catalogue of neutral losses being incorporated into database search algorithms to improve peptide identification specificity and to further advance characterization of the acidic proteome. PMID:22290482

Issues in neutral currents

International Nuclear Information System (INIS)

Sehgal, L.M.

1980-01-01

The experimental results on low energy confirming the structure of the effective Lagrangian of the weak neutral current processes as predicted by the Salam-Weinberg model are reviewed. Some possible modifications of the effective Lagrangian and the feasibility of their experimental verification are also considered. (P.L.)

Weak neutral currents discovery: a giant step for particle physics

International Nuclear Information System (INIS)

Pullia, A.; Vialle, J.P.

2010-01-01

Subatomic particles interact with different kinds of forces (strong, electromagnetic, weak and gravitational). In case of the weak force, the interaction is due to the exchange of intermediate charged (W +,- ) and neutral (Z 0 ) bosons. These cases are referred as 'charged currents' and 'neutral currents', respectively. The evidence for such weak neutral currents appeared in the Gargamelle international collaboration whose aim was to study in-depth neutrino interactions (and thus weak interactions) through the use of a giant heavy liquid bubble chamber at CERN. In a collaboration meeting in March 1972, the Milan team showed the first hints of neutral currents in neutrino interactions with at least one pion outgoing. In 1974, 2 new leptonic neutral current candidate events were found in Gargamelle films and the Fermilab team confirmed the result a few months later. (A.C.)

Generation of intense polarized beams by selective neutralization of negative ions

International Nuclear Information System (INIS)

Hershcovitch, A.I.; Hinds, E.A.

1983-01-01

A novel scheme is proposed. This method is based on selective neutralization by laser negative hydrogen ions in a magnetic field. This selectivity is based on the fact that the final state of the neutralized atom depends on nuclear polarization in the magnetic field. A two-scenario approach is to be followed: one in which the resulting neutral atom is in the ground state, and in the other the neutral atom is in the n = 2 level. Limiting factors are discussed. The main advantages of this scheme are the availability of multi-ampere negative ion sources and the possibility to neutralize negative ions with very high efficiency. 15 references, 2 figures

Active neutral particle diagnostics for high temperature plasma

International Nuclear Information System (INIS)

Tobita, Kenji

1993-01-01

This paper describes experimental studies related to active neutral particle diagnostics in the JT-60 tokamak. Detection efficiencies of a micro-channel plate (MCP), which has widely used in plasma diagnostics, were determined for ions and neutrals. Multi-step processes for a neutral beam is predicted to enhance the beam stopping cross section in a plasma. In order to confirm the predictions, shine-through for a hydrogen and for a helium beam was measured in the JT-60 ohmic plasmas. The measurements for a hydrogen beam resulted in the cross sectional enhancement in the beam stopping. The same experiment using a helium beam indicated that the cross sectional enhancement for helium was much smaller than that for hydrogen at almost same plasma parameters. Ion temperature diagnostic using active beam scattering was developed in data processing technique, in consideration of the device function of a neutral particle analyzer and in estimation of the effect of beam ion component. Fundamental experiments for detecting helium ions in a plasma were performed using two-electron transfer reaction between a helium atomic beam and helium ions, and the energy distribution and the density of the helium ions were determined. These experiments demonstrated promise of the two-electron transfer reaction as an alpha ash detection in a burning plasma. A parasitic neutral efflux accompanied by active beam injection was investigated. (J.P.N.)

Disruption Neutral Point Experiment on Alcator C-Mod

Science.gov (United States)

Granetz, R. S.; Nakamura, Y.

2000-10-01

Disruptions of single-null elongated plasmas generally result in loss of vertical position control, leading to a current quench occurring at the top or bottom of the machine, with all the attendant problems of halo and eddy currents flowing in divertor structures. On JT-60U, it has been found that if the plasma is operated with its magnetic axis at a particular height, called the neutral point, the initial vertical drift after a thermal quench is significantly slower than usual, and sometimes can even be arrested, thereby avoiding a current quench in the divertor region entirely. In an ongoing collaboration between MIT and JAERI, the neutral point concept is being tested in Alcator C-Mod, which has a significantly higher plasma elongation than JT-60U (1.65 vs 1.3). Calculations using TSC predict a neutral point at z~=+1 cm above the midplane (a=22 cm). The existence of a neutral point has now been experimentally confirmed, albeit at a height of z=+2.7 cm. The plasma has remained vertically stable for up to 9 ms after the disruption thermal quench, which in principle, is long enough for the PF control system to respond, if programmed appropriately. In addition, the physics of the neutral point stability on C-Mod appears to be somewhat different than that on JT-60U.

El silencio bajo la última Dictadura Militar en la Argentina

Directory of Open Access Journals (Sweden)

Mercedes María Barros

2009-12-01

Full Text Available This paper explores the issue of silence under the last military dictatorship in Argentina (1976-1983. Silence spread rapidly in Argentine society during the first years of the so called National Reorganization Process (PRN and it became crucial for the maintenance of the illegal regime, This silence was actually assured not only by the action of the military government, but also by the clear identification of the political and social forces with the aims and values of the Proceso. However, this prevailing silence and the resulting failure of the existing discourses to articulate the effects of the dirty war resulted in a temporal suspension of meaning within the reality of the PRN. Silence became then the instance that would finally put into question the apparently smooth functioning of the PRN and would force the emergence and constitution of a new social movement and a new language of human rights in the country.

Implementation of Trauma-Informed Care and Brief Solution-Focused Therapy: A Quality Improvement Project Aimed at Increasing Engagement on an Inpatient Psychiatric Unit.

Science.gov (United States)

Aremu, Babatunde; Hill, Pamela D; McNeal, Joanne M; Petersen, Mary A; Swanberg, Debbie; Delaney, Kathleen R

2018-03-14

Addressing tense and escalating situations with noncoercive measures is an important element of inpatient psychiatric treatment. Although restraint rates are frequently monitored, the use of pro re nata (PRN) intramuscular (IM) injections to address agitation is also an important indicator. In 2015, at the current study site, a significant increase was noted in PRN IM medication use despite unit leadership's efforts to build a culture of trauma-informed care (TIC). The purpose of the current quality improvement project was to educate staff on methods to incorporate TIC into daily practice and the use of brief solution-focused therapy techniques in escalating situations. Measurement of attitudes toward patient aggression and engagement with patients followed two waves of staff education. Upon completion of the project, a decrease in PRN IM medications, improvement in staff attitudes toward patient aggression, and improved sense of staff competency in handling tense situations were noted. [Journal of Psychosocial Nursing and Mental Health Services, xx(x), xx-xx.]. Copyright 2018, SLACK Incorporated.

Empirical evaluation of neutral interactions in host-parasite networks.

Science.gov (United States)

Canard, E F; Mouquet, N; Mouillot, D; Stanko, M; Miklisova, D; Gravel, D

2014-04-01

While niche-based processes have been invoked extensively to explain the structure of interaction networks, recent studies propose that neutrality could also be of great importance. Under the neutral hypothesis, network structure would simply emerge from random encounters between individuals and thus would be directly linked to species abundance. We investigated the impact of species abundance distributions on qualitative and quantitative metrics of 113 host-parasite networks. We analyzed the concordance between neutral expectations and empirical observations at interaction, species, and network levels. We found that species abundance accurately predicts network metrics at all levels. Despite host-parasite systems being constrained by physiology and immunology, our results suggest that neutrality could also explain, at least partially, their structure. We hypothesize that trait matching would determine potential interactions between species, while abundance would determine their realization.

Factsheet on Energy Neutral Housing Construction; Infoblad Energieneutrale woningbouw

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-08-15

A brief overview is given of all aspects of energy-neutral building and renovating homes. Besides technique, also attention is given to process, financing, management and maintenance. This factsheet is part of a series of three factsheets on energy neutral construction of houses and buildings. The other two are: 'Factsheet on Energy Neutral Building : Definition and ambition' and 'Factsheet Energy Neutral schools and offices' [Dutch] Een kort overzicht wordt gegeven van alle aspecten van energieneutraal bouwen en renoveren van woningen. Naast techniek komen ook proces, financiering en beheer en onderhoud aan de orde. Dit Infoblad maakt deel uit van een serie van drie Infobladen over energieneutraal bouwen voor woningen en gebouwen. De andere twee zijn: 'Infoblad Energieneutraal bouwen: definitie en ambitie' en 'Infoblad Energieneutrale scholen en kantoren'.

Light-induced cation exchange for copper sulfide based CO2 reduction.

Science.gov (United States)

Manzi, Aurora; Simon, Thomas; Sonnleitner, Clemens; Döblinger, Markus; Wyrwich, Regina; Stern, Omar; Stolarczyk, Jacek K; Feldmann, Jochen

2015-11-11

Copper(I)-based catalysts, such as Cu2S, are considered to be very promising materials for photocatalytic CO2 reduction. A common synthesis route for Cu2S via cation exchange from CdS nanocrystals requires Cu(I) precursors, organic solvents, and neutral atmosphere, but these conditions are not compatible with in situ applications in photocatalysis. Here we propose a novel cation exchange reaction that takes advantage of the reducing potential of photoexcited electrons in the conduction band of CdS and proceeds with Cu(II) precursors in an aqueous environment and under aerobic conditions. We show that the synthesized Cu2S photocatalyst can be efficiently used for the reduction of CO2 to carbon monoxide and methane, achieving formation rates of 3.02 and 0.13 μmol h(-1) g(-1), respectively, and suppressing competing water reduction. The process opens new pathways for the preparation of new efficient photocatalysts from readily available nanostructured templates.

Neutral hydrogen in the post-reionization universe

Science.gov (United States)

Padmanabhan, Hamsa

2018-05-01

The evolution of neutral hydrogen (HI) across redshifts is a powerful probe of cosmology, large scale structure in the universe and the intergalactic medium. Using a data-driven halo model to describe the distribution of HI in the post-reionization universe (z ~ 5 to 0), we obtain the best-fitting parameters from a rich sample of observational data: low redshift 21-cm emission line studies, intermediate redshift intensity mapping experiments, and higher redshift Damped Lyman Alpha (DLA) observations. Our model describes the abundance and clustering of neutral hydrogen across redshifts 0 - 5, and is useful for investigating different aspects of galaxy evolution and for comparison with hydrodynamical simulations. The framework can be applied for forecasting future observations with neutral hydrogen, and extended to the case of intensity mapping with molecular and other line transitions at intermediate redshifts.

Soluble HIV-1 envelope immunogens derived from an elite neutralizer elicit cross-reactive V1V2 antibodies and low potency neutralizing antibodies.

Directory of Open Access Journals (Sweden)

Sara Carbonetti

Full Text Available We evaluated four gp140 Envelope protein vaccine immunogens that were derived from an elite neutralizer, subject VC10042, whose plasma was able to potently neutralize a wide array of genetically distinct HIV-1 isolates. We sought to determine whether soluble Envelope proteins derived from the viruses circulating in VC10042 could be used as immunogens to elicit similar neutralizing antibody responses by vaccination. Each gp140 was tested in its trimeric and monomeric forms, and we evaluated two gp140 trimer vaccine regimens in which adjuvant was supplied at all four immunizations or at only the first two immunizations. Interestingly, all four Envelope immunogens elicited high titers of cross-reactive antibodies that recognize the variable regions V1V2 and are potentially similar to antibodies linked with a reduced risk of HIV-1 acquisition in the RV144 vaccine trial. Two of the four immunogens elicited neutralizing antibody responses that neutralized a wide array of HIV-1 isolates from across genetic clades, but those responses were of very low potency. There were no significant differences in the responses elicited by trimers or monomers, nor was there a significant difference between the two adjuvant regimens. Our study identified two promising Envelope immunogens that elicited anti-V1V2 antibodies and broad, but low potency, neutralizing antibody responses.

Post-Test Inspection of NASA's Evolutionary Xenon Thruster Long-Duration Test Hardware: Discharge and Neutralizer Cathodes

Science.gov (United States)

Shastry, Rohit; Soulas, George C.

2016-01-01

The NEXT Long-Duration Test is part of a comprehensive thruster service life assessment intended to demonstrate overall throughput capability, validate service life models, quantify wear rates as a function of time and operating condition, and identify any unknown life-limiting mechanisms. The test was voluntarily terminated in February 2014 after demonstrating 51,184 hours of high-voltage operation, 918 kg of propellant throughput, and 35.5 MN-s of total impulse. The post-test inspection of the thruster hardware began shortly afterwards with a combination of non-destructive and destructive analysis techniques, and is presently nearing completion. This paper presents relevant results of the post-test inspection for both discharge and neutralizer cathodes. Discharge keeper erosion was found to be significantly reduced from what was observed in the NEXT 2 kh wear test and NSTAR Extended Life Test, providing adequate protection of vital cathode components throughout the test with ample lifetime remaining. The area of the discharge cathode orifice plate that was exposed by the keeper orifice exhibited net erosion, leading to cathode plate material building up in the cathode-keeper gap and causing a thermally-induced electrical short observed during the test. Significant erosion of the neutralizer cathode orifice was also found and is believed to be the root cause of an observed loss in flow margin. Deposition within the neutralizer keeper orifice as well as on the downstream surface was thicker than expected, potentially resulting in a facility-induced impact on the measured flow margin from plume mode. Neutralizer keeper wall erosion on the beam side was found to be significantly lower compared to the NEXT 2 kh wear test, likely due to the reduction in beam extraction diameter of the ion optics that resulted in decreased ion impingement. Results from the post-test inspection have led to some minor thruster design improvements.

Net Neutrality and Its Implications to Online Learning

Science.gov (United States)

Yamagata-Lynch, Lisa C.; Despande, Deepa R.; Do, Jaewoo; Garty, Erin; Mastrogiovanni, Jason M.; Teagu, Stephanie J.

2017-01-01

In this article, we studied net neutrality as a complex sociocultural phenomenon that can affect the works of distance education scholars and online learners. We decided to take part in this research because many distance education scholars and learners take net neutrality for granted. We engaged in a qualitative investigation of US public…

Disposal of leached residual in heap leaching by neutralization

International Nuclear Information System (INIS)

Wang Jingmin

1993-01-01

The disposal results of leached residual with lime are described. Using the ratio of residual to lime being 100 : 1 the ideal disposal results were obtained with the effluent of the neutralized residual close to neutral

Water absorption in neutralized Nafion membranes

International Nuclear Information System (INIS)

Rodmacq, B.; Roche, E.; Pineri, M.; Escoubez, M.; Duplessix, R.; Eisenberg, A.

1979-01-01

In this paper some results are reported about the interactions between water and Nafion neutralized with different cations. The energy of water absorption have been measured in the whole range of relative humidity pressures. Moessbauer spectra permit to get information about the change of environment of the iron atoms during the hydration. Small angle neutron and X ray scattering experiments have then been performed to define a possible phase segregation. From these results a model of clustering in the Nafion membranes is proposed. The neutralized Nafion samples have been obtained by soaking the acid samples in solutions containing the different salts

Neutral Naturalness from Orbifold Higgs Models

Science.gov (United States)

Craig, Nathaniel; Knapen, Simon; Longhi, Pietro

2015-02-01

We present a general class of natural theories in which the Higgs boson is a pseudo-Goldstone boson in an orbifolded gauge theory. The symmetry protecting the Higgs boson at low energies is an accidental global symmetry of the quadratic action, rather than a full continuous symmetry. The lightest degrees of freedom protecting the weak scale carry no standard model (SM) quantum numbers and interact with visible matter principally through the Higgs portal. This opens the door to the systematic study of "neutral naturalness": natural theories with SM-neutral states that are as yet untested by the LHC.

Net Neutrality: Background and Issues

National Research Council Canada - National Science Library

Gilroy, Angele A

2006-01-01

.... The move to place restrictions on the owners of the networks that compose and provide access to the Internet, to ensure equal access and nondiscriminatory treatment, is referred to as "net neutrality...

Consumer Ethical Decision Making: Intensity, Self-Consciousness and Neutralization Techniques

Directory of Open Access Journals (Sweden)

Syed Afzal Moshadi Shah

2017-03-01

Full Text Available The purpose of the study is to examine the effect of moral intensity on self-conscious emotions and neutralization techniques in the context of ethical decision making among consumers. A sample of 388 shopping mall retail consumers was recruited through self-administered survey technique. Descriptive statistics, exploratory factor analysis, correlation was carried out in SPSS whereas the measurement model and structural relationships were estimated using AMOS. Results indicate that moral intensity positively influences consumer’s self-consciousness, neutralization techniques and behavioural intention. Self-consciousness negatively influence consumer’s defence mechanism i.e. neutralization techniques. Neither self-consciousness nor neutralization techniques is found to have an impact on consumers’ behavioural intention. Only self-consciousness is found to complementary mediate the relationship of moral intensity and neutralization. The limitations associated with field survey and crosssectional research design are inevitable. The study offers some relevant practical implications for government, marketing professionals and academia. The study is among the pioneer studies that theoretically links and empirically examines Issue Contingent Model, theory of neutralization and self-consciousness. The study develops and tested an Urdu language version of the questionnaire for retail consumers.

Testing the Neutral Theory of Biodiversity with Human Microbiome Datasets.

Science.gov (United States)

Li, Lianwei; Ma, Zhanshan Sam

2016-08-16

The human microbiome project (HMP) has made it possible to test important ecological theories for arguably the most important ecosystem to human health-the human microbiome. Existing limited number of studies have reported conflicting evidence in the case of the neutral theory; the present study aims to comprehensively test the neutral theory with extensive HMP datasets covering all five major body sites inhabited by the human microbiome. Utilizing 7437 datasets of bacterial community samples, we discovered that only 49 communities (less than 1%) satisfied the neutral theory, and concluded that human microbial communities are not neutral in general. The 49 positive cases, although only a tiny minority, do demonstrate the existence of neutral processes. We realize that the traditional doctrine of microbial biogeography "Everything is everywhere, but the environment selects" first proposed by Baas-Becking resolves the apparent contradiction. The first part of Baas-Becking doctrine states that microbes are not dispersal-limited and therefore are neutral prone, and the second part reiterates that the freely dispersed microbes must endure selection by the environment. Therefore, in most cases, it is the host environment that ultimately shapes the community assembly and tip the human microbiome to niche regime.

Novel neutralized-beam intense neutron source for fusion technology development

International Nuclear Information System (INIS)

Osher, J.E.; Perkins, L.J.

1983-01-01

We describe a neutralized-beam intense neutron source (NBINS) as a relevant application of fusion technology for the type of high-current ion sources and neutral beamlines now being developed for heating and fueling of magnetic-fusion-energy confinement systems. This near-term application would support parallel development of highly reliable steady-state higher-voltage neutral D 0 and T 0 beams and provide a relatively inexpensive source of fusion neutrons for materials testing at up to reactor-like wall conditions. Beam-target examples described incude a 50-A mixed D-T total (ions plus neutrals) space-charge-neutralized beam at 120 keV incident on a liquid Li drive-in target, or a 50-A T 0 + T + space-charge-neutralized beam incident on either a LiD or gas D 2 target with calculated 14-MeV neutron yields of 2 x 10 15 /s, 7 x 10 15 /s, or 1.6 x 10 16 /s, respectively. The severe local heat loading on the target surface is expected to limit the allowed beam focus and minimum target size to greater than or equal to 25 cm 2

Auger vs resonance neutralization in low energy He+ ion scattering

International Nuclear Information System (INIS)

Woodruff, D.P.

1983-01-01

He + ions incident on a metal surface can neutralize either by an Auger or resonant charge exchange. While the Auger process has always been thought to be dominant, recent theoretical interest in the simpler one-electron resonance process has led to suggestions that this alone can account for the neutralization seen in low energy He + ion scattering. In this paper this assertion is analysed by looking at the wider information available on charge exchange processes for He + ion scattering through comparison with Li + ion scattering, the importance of multiple scattering in both these scattering experiments and the results of ion neutralization spectroscopy. These lead to the conclusion that while resonance neutralization to produce metastable He* may well occur at a substantial rate in He + ion scattering, the dominant process leading to loss of ions from the final scattered signal is Auger neutralization as originally proposed. (author)

Component design description of the neutral beam injectors for PLT

International Nuclear Information System (INIS)

Johnson, R.L.; Baer, M.B.; Dagenhart, W.K.; Haselton, H.H.; Mann, T.L.; Queen, C.C.; Stirling, W.L.; Whitfield, P.W.

1977-01-01

Plasma heating by injection of high energy neutrals is one of the experiments to be carried out on Princeton Large Torus (PLT). A four unit neutral beam injection system has been designed, built and tested which should inject a total of 3 MW of neutrals into PLT with a 200 millisecond pulse length. A typical system unit is described where the major components are identified. The following discussion describes each of these items along with some details of the design and fabrication problems encountered. Some early design considerations addressed the problems of separation and dumping of residual ions from the neutral beam, calorimetry of the neutrals with incident fuxes of 25 KW/cm 2 , and pumping speeds of several hundred thousand liters per second for hydrogen gas. Solutions were found for these problems while also resolving the complex dilemma of interfacing four large systems to a tokamak

The edge of neutral evolution in social dilemmas

Energy Technology Data Exchange (ETDEWEB)

Cremer, Jonas; Frey, Erwin [Arnold Sommerfeld Center for Theoretical Physics and Center for NanoScience, Department of Physics, Ludwig-Maximilians-Universitaet Muenchen, Theresienstrasse 37, D-80333 Muenchen (Germany); Reichenbach, Tobias [Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, Rockefeller University, 1230 York Avenue, New York, NY 10065 (United States)], E-mail: jonas.cremer@physik.uni-muenchen.de

2009-09-15

The functioning of animal as well as human societies fundamentally relies on cooperation. Yet, defection is often favorable for the selfish individual, and social dilemmas arise. Selection by individuals' fitness, usually the basic driving force of evolution, quickly eliminates cooperators. However, evolution is also governed by fluctuations that can be of greater importance than fitness differences, and can render evolution effectively neutral. Here, we investigate the effects of selection versus fluctuations in social dilemmas. By studying the mean extinction times of cooperators and defectors, a variable sensitive to fluctuations, we are able to identify and quantify an emerging 'edge of neutral evolution' that delineates regimes of neutral and Darwinian evolution. Our results reveal that cooperation is significantly maintained in the neutral regimes. In contrast, the classical predictions of evolutionary game theory, where defectors beat cooperators, are recovered in the Darwinian regimes. Our studies demonstrate that fluctuations can provide a surprisingly simple way to partly resolve social dilemmas. Our methods are generally applicable to estimate the role of random drift in evolutionary dynamics.

The edge of neutral evolution in social dilemmas

International Nuclear Information System (INIS)

Cremer, Jonas; Frey, Erwin; Reichenbach, Tobias

2009-01-01

The functioning of animal as well as human societies fundamentally relies on cooperation. Yet, defection is often favorable for the selfish individual, and social dilemmas arise. Selection by individuals' fitness, usually the basic driving force of evolution, quickly eliminates cooperators. However, evolution is also governed by fluctuations that can be of greater importance than fitness differences, and can render evolution effectively neutral. Here, we investigate the effects of selection versus fluctuations in social dilemmas. By studying the mean extinction times of cooperators and defectors, a variable sensitive to fluctuations, we are able to identify and quantify an emerging 'edge of neutral evolution' that delineates regimes of neutral and Darwinian evolution. Our results reveal that cooperation is significantly maintained in the neutral regimes. In contrast, the classical predictions of evolutionary game theory, where defectors beat cooperators, are recovered in the Darwinian regimes. Our studies demonstrate that fluctuations can provide a surprisingly simple way to partly resolve social dilemmas. Our methods are generally applicable to estimate the role of random drift in evolutionary dynamics.

Neutral pumping rates for a next step tokamak ignition device

International Nuclear Information System (INIS)

Galambos, J.D.; Peng, Y.K.M.; Heifetz, D.

1985-01-01

Neutral pumping rates are calculated for pump-limiter and divertor options of a next step tokamak ignition device using a method that accounts for the coupled effects of neutral transport and plasma transport. For both pump limiters and divertors the plasma flow into the channel surrounding the neutralizer plate is greatly reduced by the neutral recycling. The fraction of this flow that is pumped can be large (>50%) but in general is dependent on the particular geometry and plasma conditions. It is estimated that pumping speeds greater than or approximately 10 5 L/s are adequate for the exhaust requirements in the pump-limiter and the divertor cases

XAS studies on selenite reduction by pyrite

International Nuclear Information System (INIS)

Kang Mingliang; Liu Chunli; Chen Fanrong; Charlet, Laurnet

2012-01-01

The interaction of aqueous Se (IV) with pyrite were systematically investigated in light of thermodynamic calculations and X-ray Absorption Spectroscopy (XAS). The results from the speciation study reveal that the reduction product is Se (O) when natural pyrite reacts with Se (N) at pH≤5.65, while small amount of FeSeO 3 or iron selenides may be formed at pH 6.1. At pH≥6.94, due to the precipitation of Fe (Ⅲ) -oxyhydroxide, the formation of the thermodynamically most stable species, FeSe 2 , is inhibited. However, when the reactive nanopyrite-greigite was used for reaction, the thermodynamically most stable species, FeSe 2 , was found for the first time as the predominant product in the present study, suggesting that 79 Se can be immobilized in its most insoluble form, FeSe 2 , in Fe (Ⅱ) -sulfide containing environment. This study confirms that pyrite can significantly attenuate the mobility of Se by reductive precipitation, and that the reaction process does not produce protons under acidic or neutral condition when Se (O) is formed. (authors)

Improved Active-Neutral-Point-Clamped (I-ANPC) Multilevel Converter: Fundamental Circuit Topology, Innovative Modulatioin Technique, and Experimental Validation

DEFF Research Database (Denmark)

Dargahi, Vahid; Corzine, Keith A.; Enslin, Johan H.

2018-01-01

For medium-voltage (MV) high-power industrial applications including HVDC and variable-speed motor drives, multilevel converters are deemed predominant topology. One of the promising derived-topologies from neutral-point-clamped (NPC) configuration is active NPC (ANPC) inverter that offers improved......-capacitor (FC) and four switches such as the insulated-gate bipolar transistors (IGBTs). The I-ANPC converter has considerable advantages over the classic multilevel inverters that makes it a preferable topology for MV applications. The substantial reduction in the number of cells in comparison with classic...

Understanding of Neutral Gas Transport in the Alcator C-Mod Tokamak Divertor

International Nuclear Information System (INIS)

Stotler, D.P.; Pitcher, C.S.; Boswell, C.J.; LaBombard, B.; Terry, J.L.; Elder, J.D.; Lisgo, S.

2002-01-01

A series of experiments on the effect of divertor baffling on the Alcator C-Mod tokamak provides stringent tests on models of neutral gas transport in and around the divertor region. One attractive feature of these experiments is that a trial description of the background plasma can be constructed from experimental measurements using a simple model, allowing the neutral gas transport to be studied with a stand-alone code. The neutral-ion and neutral-neutral elastic scattering processes recently added to the DEGAS 2 Monte Carlo neutral transport code permit the neutral gas flow rates between the divertor and main chamber to be simulated more realistically than before. Nonetheless, the simulated neutral pressures are too low and the deuterium Balmer-alpha emission profiles differ qualitatively from those measured, indicating an incomplete understanding of the physical processes involved in the experiment. Some potential explanations are examined and opportunities for future exploration a re highlighted. Improvements to atomic and surface physics data and models will play a role in the latter

Performance of the PDX neutral beam wall armor

International Nuclear Information System (INIS)

Kugel, H.W.; Eubank, H.P.; Kozub, T.A.; Williams, M.D.

1985-02-01

The PDX wall armor was designed to function as an inner wall thermal armor, a neutral beam diagnostic, and a large area inner toroidal plasma limiter. In this paper we discuss its thermal performance as wall armor during two years of PDX neutral beam heating experiments. During this period it provided sufficient inner wall protection to permit perpendicular heating injections into normal and disruptive plasmas as well as injections in the absence of plasma involving special experiments, calibrations, and tests important for the optimization and development of the PDX neutral beam injection system. Many of the design constraints and performance issues encountered in this work are relevant to the design of larger fusion devices

Negative Charge Neutralization in the Loops and Turns of Outer Membrane Phospholipase A Impacts Folding Hysteresis at Neutral pH.

Science.gov (United States)

McDonald, Sarah K; Fleming, Karen G

2016-11-08

Hysteresis in equilibrium protein folding titrations is an experimental barrier that must be overcome to extract meaningful thermodynamic quantities. Traditional approaches to solving this problem involve testing a spectrum of solution conditions to find ones that achieve path independence. Through this procedure, a specific pH of 3.8 was required to achieve path independence for the water-to-bilayer equilibrium folding of outer membrane protein OmpLA. We hypothesized that the neutralization of negatively charged side chains (Asp and Glu) at pH 3.8 could be the physical basis for path-independent folding at this pH. To test this idea, we engineered variants of OmpLA with Asp → Asn and Glu → Gln mutations to neutralize the negative charges within various regions of the protein and tested for reversible folding at neutral pH. Although not fully resolved, our results show that these mutations in the periplasmic turns and extracellular loops are responsible for 60% of the hysteresis in wild-type folding. Overall, our study suggests that negative charges impact the folding hysteresis in outer membrane proteins and their neutralization may aid in protein engineering applications.

A New Neutral-pH Low-GDP Peritoneal Dialysis Fluid

Science.gov (United States)

Himmele, Rainer; Jensen, Lynn; Fenn, Dominik; Ho, Chih-Hu; Sawin, Dixie-Ann; Diaz-Buxo, Jose A.

2012-01-01

♦ Background: Conventional peritoneal dialysis fluids (PDFs) consist of ready-to-use solutions with an acidic pH. Sterilization of these fluids is known to generate high levels of glucose degradation products (GDPs). Although several neutral-pH, low-GDP PD solutions have been developed, none are commercially available in the United States. We analyzed pH and GDPs in Delflex Neutral pH (Fresenius Medical Care North America, Waltham, MA, USA), the first neutral-pH PDF to be approved by the US Food and Drug Administration. ♦ Methods: We evaluated whether patients (n = 26; age range: 18 - 78 years) could properly mix the Delflex Neutral pH PDF after standardized initial training. We further analyzed the concentrations of 10 different glucose degradation products in Delflex Neutral pH PDF and compared the results with similar analyses in other commercially available biocompatible PDFs. ♦ Results: All pH measurements (n = 288) in the delivered Delflex Neutral pH solution consistently fell within the labeled range of 7.0 ± 0.4. Analysis of mixing errors showed no significant impact on the pH results. Delflex Neutral pH, Balance (Fresenius Medical Care, Bad Homburg, Germany), BicaVera (Fresenius Medical Care), and Gambrosol Trio (Gambro Lundia AB, Lund, Sweden) exhibited similar low total GDP concentrations, with maximums in the 4.25% solutions of 88 μmol/L, 74 μmol/L, 74 μmol/L, and 79 μmol/L respectively; the concentration in Physioneal (Baxter Healthcare Corporation, Deerfield, IL, USA) was considerably higher at 263.26 μmol/L. The total GDP concentration in Extraneal (Baxter Healthcare Corporation) was 63 μmol/L, being thus slightly lower than the concentrations in the 4.25% glucose solutions, but higher than the concentrations in the 1.5% and 2.5% glucose solutions. ♦ Conclusions: The new Delflex Neutral pH PDF consistently delivers neutral pH with minimal GDPs. PMID:22383632

Beam profile effects on NPB [neutral particle beam] performance

International Nuclear Information System (INIS)

LeClaire, R.J. Jr.

1988-03-01

A comparison of neutral particle beam brightness for various neutral beam profiles indicates that the widely used assumption of a Gaussian profile may be misleading for collisional neutralizers. An analysis of available experimental evidence shows that lower peaks and higher tails, compared to a Gaussian beam profile, are observed out of collisional neutralizers, which implies that peak brightness is over estimated, and for a given NPB platform-to-target range, the beam current (power), dwell time or some combination of such engagement parameters would have to be altered to maintain a fixed dose on target. Based on the present analysis, this factor is nominally about 2.4 but may actually be as low as 1.8 or as high as 8. This is an important consideration in estimating NPB constellation performance in SDI engagement contexts. 2 refs., 6 figs

Quantum delayed-choice experiment with a single neutral atom.

Science.gov (United States)

Li, Gang; Zhang, Pengfei; Zhang, Tiancai

2017-10-01

We present a proposal to implement a quantum delayed-choice (QDC) experiment with a single neutral atom, such as a rubidium or cesium atom. In our proposal, a Ramsey interferometer is adopted to observe the wave-like or particle-like behaviors of a single atom depending on the existence or absence of the second π/2-rotation. A quantum-controlled π/2-rotation on target atom is realized through a Rydberg-Rydberg interaction by another ancilla atom. It shows that a heavy neutral atom can also have a morphing behavior between the particle and the wave. The realization of the QDC experiment with such heavy neutral atoms not only is significant to understand the Bohr's complementarity principle in matter-wave and matter-particle domains but also has great potential on the quantum information process with neutral atoms.

Carbon footprint reductions via grid energy storage systems

Energy Technology Data Exchange (ETDEWEB)

Hale, Trevor S. [Naval Facilities Engineering Service Center, 1100 23rd Avenue, Port Huenem, CA 93043 (United States); Department of Management, Marketing, and Business Administration, University of Houston - Downtown, Houston, Texas (United States); Weeks, Kelly [Department of Maritime Administration, Texas A and M University at Galveston, Galveston, TX 77553 (United States); Tucker, Coleman [Department of Management, Marketing, and Business Administration, University of Houston - Downtown, Houston, Texas 77002 (United States)

2011-07-01

This effort presents a framework for reducing carbon emissions through the use of large-scale grid-energy-storage (GES) systems. The specific questions under investigation herein are as follows: Is it economically sound to invest in a GES system and is the system at least carbon footprint neutral? This research will show the answer to both questions is in the affirmative. Scilicet, when utilized judiciously, grid energy storage systems can be both net present value positive as well as be total carbon footprint negative. The significant contribution herein is a necessary and sufficient condition for achieving carbon footprint reductions via grid energy storage systems.

Simulation of dense recombining divertor plasmas with a Navier endash Stokes neutral transport model

International Nuclear Information System (INIS)

Knoll, D.A.; McHugh, P.R.; Krasheninnikov, S.I.; Sigmar, D.J.

1996-01-01

A two-dimensional combined edge plasma Navier endash Stokes neutral transport model is presented for the simulation of dense recombining divertor plasmas. This model includes ions, electrons, and neutral atoms which undergo Coulomb collisions, electron impact ionization, ion endash neutral elastic collisions, three-body and radiative recombination, and neutral endash neutral collisions. The advanced fully implicit solution algorithm is briefly described and a variety of results on a model geometry are presented. It is shown that interesting neutral flow patterns can exist and that these flows can convect significant energy. A solution that ignores neutral endash neutral collisions is shown to be quantitatively different from one that includes neutral endash neutral collisions. Solutions are also shown to be sensitive to the plasma opacity for Lyman α radiation. copyright 1996 American Institute of Physics

Development and evaluation of a novel high-throughput image-based fluorescent neutralization test for detection of Zika virus infection.

Science.gov (United States)

Koishi, Andrea Cristine; Suzukawa, Andréia Akemi; Zanluca, Camila; Camacho, Daria Elena; Comach, Guillermo; Duarte Dos Santos, Claudia Nunes

2018-03-01

Zika virus (ZIKV) is an emerging arbovirus belonging to the genus flavivirus that comprises other important public health viruses, such as dengue (DENV) and yellow fever (YFV). In general, ZIKV infection is a self-limiting disease, however cases of Guillain-Barré syndrome and congenital brain abnormalities in newborn infants have been reported. Diagnosing ZIKV infection remains a challenge, as viral RNA detection is only applicable until a few days after the onset of symptoms. After that, serological tests must be applied, and, as expected, high cross-reactivity between ZIKV and other flavivirus serology is observed. Plaque reduction neutralization test (PRNT) is indicated to confirm positive samples for being more specific, however it is laborious intensive and time consuming, representing a major bottleneck for patient diagnosis. To overcome this limitation, we developed a high-throughput image-based fluorescent neutralization test for ZIKV infection by serological detection. Using 226 human specimens, we showed that the new test presented higher throughput than traditional PRNT, maintaining the correlation between results. Furthermore, when tested with dengue virus samples, it showed 50.53% less cross reactivity than MAC-ELISA. This fluorescent neutralization test could be used for clinical diagnosis confirmation of ZIKV infection, as well as for vaccine clinical trials and seroprevalence studies.

QCD predictions for weak neutral current structure functions

International Nuclear Information System (INIS)

Wu Jimin

1987-01-01

Employing the analytic expression (to the next leading order) for non-singlet component of structure function which the author got from QCD theory and putting recent experiment result of neutral current structure function at Q 2 = 11 (GeV/C) 2 as input, the QCD prediction for neutral current structure function of their scaling violation behaviours was given

Direct СP violation in neutral kaon decays

Indian Academy of Sciences (India)

The final result of the NA48 experiment is presented and performed at the CERN SPS neutral kaon beams, on the direct CP violation parameter Re ( ′ / ) , as measured from the decay rates of neutral kaons into two pions. The data collected in the years 1997-2001 yield the evidence for the direct CP violation with Re ...

Mod en neutral seksualitet!

DEFF Research Database (Denmark)

Leer, Jonatan

2013-01-01

Towards a Neutral Sexuality! or Roland Barthes as a Queer Thinker? This article argues that the work of Roland Barthes has interesting perspectives in common with the queer theory. This argument will be put forward by using his concept of ‘the neutral’ that Barthes defines as “that which outplays...

Model reduction for the dynamics and control of large structural systems via neutral network processing direct numerical optimization

Science.gov (United States)

Becus, Georges A.; Chan, Alistair K.

1993-01-01

Three neural network processing approaches in a direct numerical optimization model reduction scheme are proposed and investigated. Large structural systems, such as large space structures, offer new challenges to both structural dynamicists and control engineers. One such challenge is that of dimensionality. Indeed these distributed parameter systems can be modeled either by infinite dimensional mathematical models (typically partial differential equations) or by high dimensional discrete models (typically finite element models) often exhibiting thousands of vibrational modes usually closely spaced and with little, if any, damping. Clearly, some form of model reduction is in order, especially for the control engineer who can actively control but a few of the modes using system identification based on a limited number of sensors. Inasmuch as the amount of 'control spillover' (in which the control inputs excite the neglected dynamics) and/or 'observation spillover' (where neglected dynamics affect system identification) is to a large extent determined by the choice of particular reduced model (RM), the way in which this model reduction is carried out is often critical.

Neutral-beam systems for magnetic-fusion reactors

International Nuclear Information System (INIS)

Fink, J.H.

1981-01-01

Neutral beams for magnetic fusion reactors are at an early stage of development, and require considerable effort to make them into the large, reliable, and efficient systems needed for future power plants. To optimize their performance to establish specific goals for component development, systematic analysis of the beamlines is essential. Three ion source characteristics are discussed: arc-cathode life, gas efficiency, and beam divergence, and their significance in a high-energy neutral-beam system is evaluated

Preliminary experiments on energy recovery on a neutral beam injector

International Nuclear Information System (INIS)

Fumelli, M.

1977-06-01

Experimental tests of energy recovery are made on an injector of energetic neutral atoms in which the ion source (the circular periplasmatron) is operated at the ground potential and the neutralizer is biased at the high negative potential corresponding to the desired neutral beam energy. To prevent the acceleration of the neutralizer plasma electrons toward the collector of the decelerated ions (the recovery electrode), a potential barrier is created by means of a negatively biased long cylindrical grid (called the suppressor grid) surrounding the beam. For a given negative potential (relative to the neutralizer) applied to this grid a plasma sheath develops at the periphery of the beam. At the entry of the grid the width of this sheath is generally much smaller than the beam radius. However, the ions are deflected by the electric field of the sheath outward through the grid. The ion density in the sheath is thus decreasing as the beam propagates and the result is a sheath-widening process which in turn causes more ions to be deflected. If the suppressor grid is sufficiently long the sheath will eventually fill the whole section of the beam, the potential on the axis will fall below the neutralizer potential and stop the electrons. Concurrently, most of the ions are deflected out of the suppressor. These ions can be decelerated and collected outside the region where the neutral beam propagates. A drawing of such a system is shown

Misconceptions and false expectations in neutral evolution

Directory of Open Access Journals (Sweden)

CARLOS Y. VALENZUELA

2000-01-01

Full Text Available Neutral evolution results from random recurrent mutation and genetic drift. A small part of random evolution, that which is related to protein or DNA polymorphisms, is the subject of the Neutral Theory of Evolution. One of the foundations of this theory is the demonstration that the mutation rate (m is equal to the substitution rate. Since both rates are independent of population size, they are independent of drift, which is dependent upon population size. Neutralists have erroneously equated the substitution rate with the fixation rate, despite the fact that they are antithetical conceptions. The neutralists then applied the random walk stochastic model to justify alleles or bases that were fixated or eliminated. In this model, once the allele or base frequencies reach the monomorphic states (values of 1.0 or 0.0, the absorbing barriers, they can no longer return to the polymorphic state. This operates in a pure mathematical model. If recurrent mutation occurs (as in biotic real systems fixation and elimination are impossible. A population of bacteria in which m=10-8 base mutation (or substitution/site/generation and the reproduction rate is 1000 cell cycle/year should replace all its genome bases in approximately 100,000 years. The expected situation for all sites is polymorphism for the four bases rather than monomorphism at 1.0 or 0.0 frequencies. If fixation and elimination of a base for more than 500,000 years are impossible, then most of the neutral theory is untenable. A new complete neutral model, which allows for recurrent substitutions, is proposed here based on recurrent mutation or substitution and drift alone. The model fits a binomial or Poisson distribution and not a geometric one, as does neutral theory.

Initial operation and performance of the PDX neutral-beam injection system

International Nuclear Information System (INIS)

Kugel, H.W.; Eubank, H.P.; Kozub, T.A.; Rossmassler, J.E.; Schilling, G.; van Halle, A.; Williams, M.D.

1982-01-01

In 1981, the joint ORNL/PPPL PDX neutral beam heating project succeeded in reliably injecting 7.2 MW of D 0 into the PDX plasma, at nearly perpendicular angles, and achieved ion temperatures up to 6.5 keV. The expeditious achievement of this result was due to the thorough conditioning and qualification of the PDX neutral beam ion sources at ORNL prior to delivery coupled with several field design changes and improvements in the injection system made at PPPL as a result of neutral beam operating experience with the PLT tokamak. It has been found that the operation of high power neutral beam injection systems in a tokamak-neutral beam environment requires procedures and performance different from those required for development operation on test stands. In this paper, we review the installatin of the PDX neutral beam injection system, and its operation and performance during the initial high power plasma heating experiments with the PDX tokamak

Self-consistent approach for neutral community models with speciation

NARCIS (Netherlands)

Haegeman, Bart; Etienne, Rampal S.

Hubbell's neutral model provides a rich theoretical framework to study ecological communities. By incorporating both ecological and evolutionary time scales, it allows us to investigate how communities are shaped by speciation processes. The speciation model in the basic neutral model is

Advanced metal artifact reduction MRI of metal-on-metal hip resurfacing arthroplasty implants: compressed sensing acceleration enables the time-neutral use of SEMAC

International Nuclear Information System (INIS)

Fritz, Jan; Thawait, Gaurav K.; Fritz, Benjamin; Raithel, Esther; Nittka, Mathias; Gilson, Wesley D.; Mont, Michael A.

2016-01-01

Compressed sensing (CS) acceleration has been theorized for slice encoding for metal artifact correction (SEMAC), but has not been shown to be feasible. Therefore, we tested the hypothesis that CS-SEMAC is feasible for MRI of metal-on-metal hip resurfacing implants. Following prospective institutional review board approval, 22 subjects with metal-on-metal hip resurfacing implants underwent 1.5 T MRI. We compared CS-SEMAC prototype, high-bandwidth TSE, and SEMAC sequences with acquisition times of 4-5, 4-5 and 10-12 min, respectively. Outcome measures included bone-implant interfaces, image quality, periprosthetic structures, artifact size, and signal- and contrast-to-noise ratios (SNR and CNR). Using Friedman, repeated measures analysis of variances, and Cohen's weighted kappa tests, Bonferroni-corrected p-values of 0.005 and less were considered statistically significant. There was no statistical difference of outcomes measures of SEMAC and CS-SEMAC images. Visibility of implant-bone interfaces and pseudocapsule as well as fat suppression and metal reduction were ''adequate'' to ''good'' on CS-SEMAC and ''non-diagnostic'' to ''adequate'' on high-BW TSE (p < 0.001, respectively). SEMAC and CS-SEMAC showed mild blur and ripple artifacts. The metal artifact size was 63 % larger for high-BW TSE as compared to SEMAC and CS-SEMAC (p < 0.0001, respectively). CNRs were sufficiently high and statistically similar, with the exception of CNR of fluid and muscle and CNR of fluid and tendon, which were higher on intermediate-weighted high-BW TSE (p < 0.005, respectively). Compressed sensing acceleration enables the time-neutral use of SEMAC for MRI of metal-on-metal hip resurfacing implants when compared to high-BW TSE and image quality similar to conventional SEMAC. (orig.)

Advanced metal artifact reduction MRI of metal-on-metal hip resurfacing arthroplasty implants: compressed sensing acceleration enables the time-neutral use of SEMAC

Energy Technology Data Exchange (ETDEWEB)

Fritz, Jan; Thawait, Gaurav K. [Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Section of Musculoskeletal Radiology, Baltimore, MD (United States); Fritz, Benjamin [University of Freiburg, Department of Radiology, Freiburg im Breisgau (Germany); Raithel, Esther; Nittka, Mathias [Siemens Healthcare GmbH, Erlangen (Germany); Gilson, Wesley D. [Siemens Healthcare USA, Inc., Baltimore, MD (United States); Mont, Michael A. [Cleveland Clinic Foundation, Department of Orthopedic Surgery, Cleveland, OH (United States)

2016-10-15

Compressed sensing (CS) acceleration has been theorized for slice encoding for metal artifact correction (SEMAC), but has not been shown to be feasible. Therefore, we tested the hypothesis that CS-SEMAC is feasible for MRI of metal-on-metal hip resurfacing implants. Following prospective institutional review board approval, 22 subjects with metal-on-metal hip resurfacing implants underwent 1.5 T MRI. We compared CS-SEMAC prototype, high-bandwidth TSE, and SEMAC sequences with acquisition times of 4-5, 4-5 and 10-12 min, respectively. Outcome measures included bone-implant interfaces, image quality, periprosthetic structures, artifact size, and signal- and contrast-to-noise ratios (SNR and CNR). Using Friedman, repeated measures analysis of variances, and Cohen's weighted kappa tests, Bonferroni-corrected p-values of 0.005 and less were considered statistically significant. There was no statistical difference of outcomes measures of SEMAC and CS-SEMAC images. Visibility of implant-bone interfaces and pseudocapsule as well as fat suppression and metal reduction were ''adequate'' to ''good'' on CS-SEMAC and ''non-diagnostic'' to ''adequate'' on high-BW TSE (p < 0.001, respectively). SEMAC and CS-SEMAC showed mild blur and ripple artifacts. The metal artifact size was 63 % larger for high-BW TSE as compared to SEMAC and CS-SEMAC (p < 0.0001, respectively). CNRs were sufficiently high and statistically similar, with the exception of CNR of fluid and muscle and CNR of fluid and tendon, which were higher on intermediate-weighted high-BW TSE (p < 0.005, respectively). Compressed sensing acceleration enables the time-neutral use of SEMAC for MRI of metal-on-metal hip resurfacing implants when compared to high-BW TSE and image quality similar to conventional SEMAC. (orig.)

Neutralization principles for the Extraction and Transport of Ion Beams

CERN Document Server

Riege, H

2000-01-01

The strict application of conventional extraction techniques of ion beams from a plasma source is characterized by a natural intensity limit determined by space charge.The extracted current may be enhanced far beyond this limit by neutralizing the space charge of the extracted ions in the first extraction gap of the source with electrons injected from the opposite side. The transverse and longitudinal emittances of a neutralized ion beam, hence its brightness, are preserved. Results of beam compensation experiments, which have been carried out with a laser ion source, are resumed for proposing a general scheme of neutralizing ion sources and their adjacent low-energy beam transport channels with electron beams. Many technical applications of high-mass ion beam neutralization technology may be identified: the enhancement of ion source output for injection into high-intensity, low-and high-energy accelerators, or ion thrusters in space technology, for the neutral beams needed for plasma heating of magnetic conf...

MODEL OF THE TOKAMAK EDGE DENSITY PEDESTAL INCLUDING DIFFUSIVE NEUTRALS

International Nuclear Information System (INIS)

BURRELL, K.H.

2003-01-01

OAK-B135 Several previous analytic models of the tokamak edge density pedestal have been based on diffusive transport of plasma plus free-streaming of neutrals. This latter neutral model includes only the effect of ionization and neglects charge exchange. The present work models the edge density pedestal using diffusive transport for both the plasma and the neutrals. In contrast to the free-streaming model, a diffusion model for the neutrals includes the effect of both charge exchange and ionization and is valid when charge exchange is the dominant interaction. Surprisingly, the functional forms for the electron and neutral density profiles from the present calculation are identical to the results of the previous analytic models. There are some differences in the detailed definition of various parameters in the solution. For experimentally relevant cases where ionization and charge exchange rate are comparable, both models predict approximately the same width for the edge density pedestal

Ion-neutral transport through quadrupole interfaces of mass-spectrometer systems

International Nuclear Information System (INIS)

Jugroot, M.; Groth, C.P.T.; Thomson, B.A.; Baranov, V.; Collings, B.A.; French, J.B.

2004-01-01

The transport of free ions through highly under-expanded jet flows of neutral gases and in the presence of applied electric fields is investigated by continuum-based numerical simulations. In particular, numerical results are described which are relevant to ion flows occurring in quadrupole interfaces of mass spectrometer systems. A five-moment mathematical model and parallel multi-block numerical solution procedure is developed for predicting the ion transport. The model incorporates the effects of ion-neutral collision processes and is used in conjunction with a Navier-Stokes model and flow solver for the neutral gas to examine the key influences controlling the ion motion. The effects of the neutral gas flow, electric fields (both dc and rf), and flow field geometry on ion mobility are carefully assessed. The capability of controlling the charged particle motions through a combination of directed neutral flow and applied electric field is demonstrated for these high-speed, hypersonic, jet flows. (author)

The impact of exospheric neutral dynamics on ring current decay

Science.gov (United States)

Ilie, R.; Liemohn, M. W.; Skoug, R. M.; Funsten, H. O.; Gruntman, M.; Bailey, J. J.; Toth, G.

2015-12-01

The geocorona plays an important role in the energy budget of the Earth's inner magnetosphere since charge exchange of energetic ions with exospheric neutrals makes the exosphere act as an energy sink for ring current particles. Long-term ring current decay following a magnetic storm is mainly due to these electron transfer reactions, leading to the formation energetic neutral atoms (ENAs) that leave the ring current system on ballistic trajectories. The number of ENAs emitted from a given region of space depends on several factors, such as the energy and species of the energetic ion population in that region and the density of the neutral gas with which the ions undergo charge exchange. However, the density and structure of the exosphere are strongly dependent on changes in atmospheric temperature and density as well as charge exchange with the ions of plasmaspheric origin, which depletes the geocorona (by having a neutral removed from the system). Moreover, the radiation pressure exerted by solar far-ultraviolet photons pushes the geocoronal hydrogen away from the Earth in an anti-sunward direction to form a tail of neutral hydrogen. TWINS ENA images provide a direct measurement of these ENA losses and therefore insight into the dynamics of the ring current decay through interactions with the geocorona. We assess the influence of geocoronal neutrals on ring current formation and decay by analysis of the predicted ENA emissions using 6 different geocoronal models and simulations from the HEIDI ring current model during storm time. Comparison with TWINS ENA images shows that the location of the peak ENA enhancements is highly dependent on the distribution of geocoronal hydrogen density. We show that the neutral dynamics has a strong influence on the time evolution of the ring current populations as well as on the formation of energetic neutral atoms.

Neutral Theory and Scale-Free Neural Dynamics

Science.gov (United States)

Martinello, Matteo; Hidalgo, Jorge; Maritan, Amos; di Santo, Serena; Plenz, Dietmar; Muñoz, Miguel A.

2017-10-01

Neural tissues have been consistently observed to be spontaneously active and to generate highly variable (scale-free distributed) outbursts of activity in vivo and in vitro. Understanding whether these heterogeneous patterns of activity stem from the underlying neural dynamics operating at the edge of a phase transition is a fascinating possibility, as criticality has been argued to entail many possible important functional advantages in biological computing systems. Here, we employ a well-accepted model for neural dynamics to elucidate an alternative scenario in which diverse neuronal avalanches, obeying scaling, can coexist simultaneously, even if the network operates in a regime far from the edge of any phase transition. We show that perturbations to the system state unfold dynamically according to a "neutral drift" (i.e., guided only by stochasticity) with respect to the background of endogenous spontaneous activity, and that such a neutral dynamics—akin to neutral theories of population genetics and of biogeography—implies marginal propagation of perturbations and scale-free distributed causal avalanches. We argue that causal information, not easily accessible to experiments, is essential to elucidate the nature and statistics of neural avalanches, and that neutral dynamics is likely to play an important role in the cortex functioning. We discuss the implications of these findings to design new empirical approaches to shed further light on how the brain processes and stores information.

CO{sub 2} neutral steam production for the production of bioethanol; CO{sub 2}-neutrale Dampferzeugung fuer die Bioethanolproduktion

Energy Technology Data Exchange (ETDEWEB)

Wetter, Christof; Bruegging, Elmar; Baumkoetter, Daniel [Fachhochschule Muenster (Germany)

2011-10-15

Conventional plants for the production of bioethanol use fossil fuels such as heating oil or lignite for the supply of process energy. The authors of the contribution under consideration report on a tightly connection of an agricultural company with a biogas plant with a distillery by means an energy center consisting of two cogeneration plants and a steam generator. With this, a CO{sub 2} neutral fuel is produced from a CO{sub 2} neutral vapor.

What is a truly neutral particle?

International Nuclear Information System (INIS)

Tsan, Ung Chan

2004-01-01

An electrically charged particle is necessarily different from its antiparticle while an electrically neutral particle is either identical with or different from its antiparticle. A truly neutral particle is a particle identical to its antiparticle, which means that all its algebraic intrinsic properties are equal to zero since particle and antiparticle have all their algebraic intrinsic properties opposite. We propose two complementary methods to recognize the true nature of any electrically neutral particle. On the one hand, any non-null algebraic intrinsic property of a particle (properties such as Q, magnetic moment already known from classical physics, or quantum numbers such as baryonic number A, lepton number L or flavors, which are meaningful only in the quantum world) reveals that it is distinct from its antiparticle. On the other hand, any particle decaying through a self-conjugate channel or/and through both two conjugate channels is a truly neutral particle implying then that all algebraic intrinsic properties, known or yet unknown, of this particle are null. According to these methods, the neutrino, like any fermion, cannot be its own antiparticle, so neutrinoless double beta decay cannot take place in nature. We point out the internal contradiction required by the existence of hypothetical neutrinoless double beta decay. We suggest that persistent failure to find experimental evidence for this decay mechanism despite huge efforts dedicated to this aim is consistent with the physics of this process. The immediate consequence would be that limits of neutrino mass deduced from neutrinoless double beta decay cannot be used as constraints in contrast with mass limits deduced from the behavior of the end-point in simple beta spectra. (author)

Molecular clock in neutral protein evolution

Directory of Open Access Journals (Sweden)

Wilke Claus O

2004-08-01

Full Text Available Abstract Background A frequent observation in molecular evolution is that amino-acid substitution rates show an index of dispersion (that is, ratio of variance to mean substantially larger than one. This observation has been termed the overdispersed molecular clock. On the basis of in silico protein-evolution experiments, Bastolla and coworkers recently proposed an explanation for this observation: Proteins drift in neutral space, and can temporarily get trapped in regions of substantially reduced neutrality. In these regions, substitution rates are suppressed, which results in an overall substitution process that is not Poissonian. However, the simulation method of Bastolla et al. is representative only for cases in which the product of mutation rate μ and population size Ne is small. How the substitution process behaves when μNe is large is not known. Results Here, I study the behavior of the molecular clock in in silico protein evolution as a function of mutation rate and population size. I find that the index of dispersion decays with increasing μNe, and approaches 1 for large μNe . This observation can be explained with the selective pressure for mutational robustness, which is effective when μNe is large. This pressure keeps the population out of low-neutrality traps, and thus steadies the ticking of the molecular clock. Conclusions The molecular clock in neutral protein evolution can fall into two distinct regimes, a strongly overdispersed one for small μNe, and a mostly Poissonian one for large μNe. The former is relevant for the majority of organisms in the plant and animal kingdom, and the latter may be relevant for RNA viruses.

A carrier-based approach for overmodulation of three-level neutral-point-lamped inverter with zero neutral-point current

DEFF Research Database (Denmark)

Maheshwari, Ram Krishan; Munk-Nielsen, Stig; Busquets-Monge, S.

2012-01-01

In a voltage source inverter, overmodulation is required to extend the range of operation and enhance the dc-link voltage utilization. A carrier-based implementation of a modulation strategy for the three-level neutral-point-clamped inverter is proposed for the overmodulation region. The modulation...... strategy ensures zero average neutral-point current in a switching period. A newly proposed boundary compression is used to regulate the dc-link voltage at all operating points. A description of the algorithm to implement the modulation strategy is also presented. The main advantage of the proposed...

Negative ion formation and neutralization processes, (1)

International Nuclear Information System (INIS)

Sugiura, Toshio

1982-01-01

This review has been made preliminary for the purpose of contribute to the plasma heating by ''negative ion based neutral beam injection'' in the magnetic confinement fusion reactor. A compilation includes the survey of the general processes of negative ion formation, the data of the cross section of H - ion formation and the neutralization of H - ion, and some of new processes of H - ion formation. The data of cross section are mainly experimental, but partly include the results of theoretical calculation. (author)

First observation of the fourth neutral polarization point in the atmosphere

Science.gov (United States)

Horvath, Gabor; Bernath, Balazs; Suhai, Bence; Barta, Andras; Wehner, Rudiger

2002-10-01

In the clear sky there are three commonly known loci, the Arago, Babinet, and Brewster neutral points, where the skylight is unpolarized. These peculiar celestial points, bearing the names of their discoverers, have been the subject of many ground-based investigations, because their positions are sensitive indicators of the amount and type of atmospheric turbidity. According to theoretical considerations and computer simulations, there should exist an additional neutral point approximately opposite to the Babinet point, which can be observed only at higher altitudes in the air or space. Until now, this anonymous fourth neutral point has not been observed during air- or space-borne polarimetric experiments and has been forgotten, in spite of the fact that the neutral points were a basic tool in atmospheric research for a century. Here, we report on the first observation of this fourth neutral point from a hot air balloon. Using 180-field-of-view imaging polarimetry, we could observe the fourth neutral point at 450, 550, and 650 nm from different altitudes between 900 and 3500 m during and after sunrise at approximately 2240 below the anti-solar point along the anti-solar meridian, depending on the wavelength and solar elevation. We show that the fourth neutral point exists at the expected location and has characteristics similar to those of the Arago, Babinet, and Brewster points. We discuss why the fourth neutral point has not been observed in previous air- or space-borne polarimetric experiments. 2002 Optical Society of America

Low-energy neutral current phenomenology and grand unified theories

International Nuclear Information System (INIS)

Del Aguila, F.; Mendez, A.

1981-01-01

We derive necessary and sufficient conditions to be satisfied by any expanded electroweak gauge model in order to reproduce the standard model low-energy neutral current predictions. These conditions imply several constraints on the neutral gauge boson masses and the quantum number assignments for the ordinary fermions. Using these conditions, we prove that the popular grand unified theories based on the gauge groups SO(10) and E6 can only accommodate trivial extensions of the standard model. As a consequence, if any of these grand unified models works at some energy scale, present low-energy neutral current phenomenology implies that the Z-boson must be produced with the expected mass and couplings to the ordinary fermions. Any additional neutral gauge boson (with the possible exception of very heavy ones) could only be produced in hadronic collisions and it would not decay in e + e - . (orig.)

Beam-induced pressure variations in a TFTR neutral-beam injector

International Nuclear Information System (INIS)

Willis, J.E.; Berkner, K.H.

1981-10-01

In neutral-beam injection systems either all or part of the gas flow into the neutralizer comes from the plasma source. When the beam is switched on, ions from the plasma source, which used to contribute to the gas flow, are converted to an energetic beam and are pumped away: hence reducing the gas input to the neutralizer. The large volume of the neutralizer and its high conductance damp out rapid changes; for example, when the gas to the source is first turned on, there is a 230 msec exponential rise time associated with pressure in the neutralizer. The neutralizer in turn acts as a source of gas to the first chamber and the first chamber to the second and so on. Beam dumps become additional sources of gas in the second chamber and target tank as gas molecules are collisionally desorbed from the surface of the dump. A simple analytical model (the equivalent of an electrical RC circuit) of the volumes and conductances of the system has been used to describe the pressure variations. The use of time dependent sources terms in the model gives an estimate of the desorption rate from the dumps and its time variation during a beam pulse

Integral Transport Analysis Results for Ions Flowing Through Neutral Gas

Science.gov (United States)

Emmert, Gilbert; Santarius, John

2017-10-01

Results of a computational model for the flow of energetic ions and neutrals through a background neutral gas will be presented. The method models reactions as creating a new source of ions or neutrals if the energy or charge state of the resulting particle is changed. For a given source boundary condition, the creation and annihilation of the various species is formulated as a 1-D Volterra integral equation that can quickly be solved numerically by finite differences. The present work focuses on multiple-pass, 1-D ion flow through neutral gas and a nearly transparent, concentric anode and cathode pair in spherical, cylindrical, or linear geometry. This has been implemented as a computer code for atomic (3He, 3He +, 3He + +) and molecular (D, D2, D-, D +, D2 +, D3 +) ion and neutral species, and applied to modeling inertial-electrostatic connement (IEC) devices. The code yields detailed energy spectra of the various ions and energetic neutral species. Calculations for several University of Wisconsin IEC and ion implantation devices will be presented. Research supported by US Dept. of Homeland Security Grant 2015-DN-077-ARI095, Dept. of Energy Grant DE-FG02-04ER54745, and the Grainger Foundation.

Temporal Trends in Analgesic Use in Long-Term Care Facilities: A Systematic Review of International Prescribing.

Science.gov (United States)

La Frenais, Francesca L; Bedder, Rachel; Vickerstaff, Victoria; Stone, Patrick; Sampson, Elizabeth L

2018-02-01

To explore global changes in the prescription of analgesic drugs over time in the international long-term care (LTC) population. Systematic review. We included original research articles in English, published and unpublished, that included number of participants, country and year(s) of data collection, and prescription of analgesics (analgesics not otherwise specified, opioids, acetaminophen; scheduled only, or scheduled plus as needed (PRN)). LTC residents. We searched PubMed, EMBASE, CINAHL, International Pharmaceutical Abstracts, PsycINFO, Cochrane, Web of Science, Google Scholar, using keywords for LTC facilities and analgesic medication; hand-searched references of eligible papers; correspondence. Studies were quality rated using an adapted Newcastle-Ottawa scale. Pearson correlation coefficients were generated between percentage of residents prescribed an analgesic and year of data collection. If available, we investigated changes in acetaminophen and opioid prescriptions. Forty studies met inclusion criteria. A moderate correlation (0.59) suggested that scheduled prescription rates for analgesics have increased over time. Similar findings were reflected in scheduled prescriptions for acetaminophen and opioids. No increase was seen when analyzing scheduled plus PRN analgesics. Use of opioids (scheduled plus PRN) appears to have increased over time. Worldwide, use of opioids and acetaminophen has increased in LTC residents. Research is needed to explore whether this reflects appropriate pain management for LTC residents and if PRN medication is used effectively. © 2017 The Authors. Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society.

Clustering and phase transitions on a neutral landscape

Science.gov (United States)

Scott, Adam D.; King, Dawn M.; Marić, Nevena; Bahar, Sonya

2013-06-01

Recent computational studies have shown that speciation can occur under neutral conditions, i.e., when the simulated organisms all have identical fitness. These works bear comparison with mathematical studies of clustering on neutral landscapes in the context of branching and coalescing random walks. Here, we show that sympatric clustering/speciation can occur on a neutral landscape whose dimensions specify only the simulated organisms’ phenotypes. We demonstrate that clustering occurs not only in the case of assortative mating, but also in the case of asexual fission; it is not observed in the control case of random mating. We find that the population size and the number of clusters undergo a second-order non-equilibrium phase transition as the maximum mutation size is varied.

Modeling Evolution on Nearly Neutral Network Fitness Landscapes

Science.gov (United States)

Yakushkina, Tatiana; Saakian, David B.

2017-08-01

To describe virus evolution, it is necessary to define a fitness landscape. In this article, we consider the microscopic models with the advanced version of neutral network fitness landscapes. In this problem setting, we suppose a fitness difference between one-point mutation neighbors to be small. We construct a modification of the Wright-Fisher model, which is related to ordinary infinite population models with nearly neutral network fitness landscape at the large population limit. From the microscopic models in the realistic sequence space, we derive two versions of nearly neutral network models: with sinks and without sinks. We claim that the suggested model describes the evolutionary dynamics of RNA viruses better than the traditional Wright-Fisher model with few sequences.

Instrumentation system for long-pulse MFTF neutral beams

International Nuclear Information System (INIS)

Risch, D.M.

1981-01-01

The instrumentation system for long pulse neutral beams for MFTFS consists of monitoring and protective circuitry. Global synchronization of high speed monitoring data across twenty-four neutral beams is achieved via an experiment wide fiber optic timing system. Fiber optics are also used as a means of isolating signals at elevated voltages. An excess current monitor, interrupt monitor, sparkdown detector, spot detector and gradient grid ratio detector form the primary protection for the neutral beam source. A unique hierarchical interlocking scheme allows other protective devices to be factored into the shutdown circuitry of the power supply so that the initiating cause of a shutdown can be isolated and even allows some non-critical devices to be safely ignored for a period of time

Neutral currents and the gauge group of weak and electromagnetic interactions

International Nuclear Information System (INIS)

Rajpoot, S.

1977-12-01

In considering the question of neutral current parity conversation, models of weak and electromagnetic interactions based on the gauge sub group SU(2)sub(L)xSU(2)sub(R)x(U) 1 are examined. The thesis is presented in the following sections: (1) Introduction. (2) Natural left-right symmetric theory and its neutral current phenomenology. (3) Effects of neutral weak currents in electron-positron annihilation. (4) Dilepton production in pp and anti pp collisions as a probe to the nature of the neutral current interaction. (U.K.)

Towards a Revised Monte Carlo Neutral Particle Surface Interaction Model

International Nuclear Information System (INIS)

Stotler, D.P.

2005-01-01

The components of the neutral- and plasma-surface interaction model used in the Monte Carlo neutral transport code DEGAS 2 are reviewed. The idealized surfaces and processes handled by that model are inadequate for accurately simulating neutral transport behavior in present day and future fusion devices. We identify some of the physical processes missing from the model, such as mixed materials and implanted hydrogen, and make some suggestions for improving the model

Preliminary experiments on energy recovery on a neutral beam injector

International Nuclear Information System (INIS)

Fumelli, M.

1977-06-01

Energy recovery tests performed on an injector of energetic neutral atoms in which the ion source is operated at the ground potential and the neutralizer is biased at the high energy potential corresponding to the desired neutral beam energy, are presented. The operation of the suppressor grid is studied in two different experiments. These tests underline the problems to be solved for an efficient recovery of the energy of the unneutralized beam fraction

Intense diagnostic neutral beam development for ITER

International Nuclear Information System (INIS)

Rej, D.J.; Henins, I.; Fonck, R.J.; Kim, Y.J.

1992-01-01

For the next-generation, burning tokamak plasmas such as ITER, diagnostic neutral beams and beam spectroscopy will continue to be used to determine a variety of plasma parameters such as ion temperature, rotation, fluctuations, impurity content, current density profile, and confined alpha particle density and energy distribution. Present-day low-current, long-pulse beam technology will be unable to provide the required signal intensities because of higher beam attenuation and background bremsstrahlung radiation in these larger, higher-density plasmas. To address this problem, we are developing a short-pulse, intense diagnostic neutral beam. Protons or deuterons are accelerated using magnetic-insulated ion-diode technology, and neutralized in a transient gas cell. A prototype 25-kA, 100-kV, 1-μs accelerator is under construction at Los Alamos. Initial experiments will focus on ITER-related issues of beam energy distribution, current density, pulse length, divergence, propagation, impurity content, reproducibility, and maintenance

Neutral beam current drive with balanced injection

International Nuclear Information System (INIS)

Eckhartt, D.

1990-01-01

Current drive with fast ions has proved its capability to sustain a tokamak plasma free of externally induced electric fields in a stationary state. The suprathermal ion population within the toroidal plasma was created by quasi-tangential and uni-directional injection of high-energy neutral atoms, their ionisation and subsequent deceleration by collisions with the background plasma particles. In future large tokamaks of the NET/INTER-type, with reactor-relevant values of plasma density and temperature, this current drive scheme is expected to maintain the toroidal current at the plasma centre, as current drive by lower hybrid waves will be restricted to the outer plasma regions owing to strong wave damping. Adequate penetration of the neutral atoms through the dense plasma requires particle energies of several hundred kilovolts per nucleon since beam absorption scales roughly with the ratio beam energy over density. The realisation of such high-energy high-power neutral beams, based on negative ion technology, is now under study. (author) 7 refs., 2 figs

Toroidal magnetic confinement of non-neutral plasmas

International Nuclear Information System (INIS)

Yoshida, Zensho; Ogawa, Yuichi; Morikawa, Junji; Himura, Haruhiko; Kondo, Shigeo; Nakashima, Chihiro; Kakuno, Shuichi; Iqbal, Muhamad; Volponi, Francesco; Shibayama, Norihisa; Tahara, Shigeru

1999-01-01

A new method of toroidal non-neutral plasma trap has been developed with applying the chaos-induced radial transport of particles near a magnetic null point. A pure electron plasma is produced by injecting an electron beam. The poloidal gyroradius of an electron at the energy of 1 keV is of order 10 mm, which determines the length scale of the chaotic region. Amongst various applications of toroidal non-neutral plasmas, a possibility of producing very high-β plasma, which is suitable for advanced fusion, has been examined. The self-electric field of a non-neutral plasma can generate a strong shear flow. When the flow velocity is comparable to the Alfven speed (which is smaller than the ion sound speed, if β>1), a high-β equilibrium can be produced in which the plasma pressure is primarily balanced by the dynamic pressure of the flow. This configuration is described by a generalized Bernoulli law

Differential emotion attribution to neutral faces of own and other races.

Science.gov (United States)

Hu, Chao S; Wang, Qiandong; Han, Tong; Weare, Ethan; Fu, Genyue

2017-02-01

Past research has demonstrated differential recognition of emotion on faces of different races. This paper reports the first study to explore differential emotion attribution to neutral faces of different races. Chinese and Caucasian adults viewed a series of Chinese and Caucasian neutral faces and judged their outward facial expression: neutral, positive, or negative. The results showed that both Chinese and Caucasian viewers perceived more Chinese faces than Caucasian faces as neutral. Nevertheless, Chinese viewers attributed positive emotion to Caucasian faces more than to Chinese faces, whereas Caucasian viewers attributed negative emotion to Caucasian faces more than to Chinese faces. Moreover, Chinese viewers attributed negative and neutral emotion to the faces of both races without significant difference in frequency, whereas Caucasian viewers mostly attributed neutral emotion to the faces. These differences between Chinese and Caucasian viewers may be due to differential visual experience, culture, racial stereotype, or expectation of the experiment. We also used eye tracking among the Chinese participants to explore the relationship between face-processing strategy and emotion attribution to neutral faces. The results showed that the interaction between emotion attribution and face race was significant on face-processing strategy, such as fixation proportion on eyes and saccade amplitude. Additionally, pupil size during processing Caucasian faces was larger than during processing Chinese faces.

Energy Conservation Tests of a Coupled Kinetic-kinetic Plasma-neutral Transport Code

Energy Technology Data Exchange (ETDEWEB)

Stotler, D. P.; Chang, C. S.; Ku, S. H.; Lang, J.; Park, G.

2012-08-29

A Monte Carlo neutral transport routine, based on DEGAS2, has been coupled to the guiding center ion-electron-neutral neoclassical PIC code XGC0 to provide a realistic treatment of neutral atoms and molecules in the tokamak edge plasma. The DEGAS2 routine allows detailed atomic physics and plasma-material interaction processes to be incorporated into these simulations. The spatial pro le of the neutral particle source used in the DEGAS2 routine is determined from the uxes of XGC0 ions to the material surfaces. The kinetic-kinetic plasma-neutral transport capability is demonstrated with example pedestal fueling simulations.

Preferential amygdala reactivity to the negative assessment of neutral faces.

Science.gov (United States)

Blasi, Giuseppe; Hariri, Ahmad R; Alce, Guilna; Taurisano, Paolo; Sambataro, Fabio; Das, Saumitra; Bertolino, Alessandro; Weinberger, Daniel R; Mattay, Venkata S

2009-11-01

Prior studies suggest that the amygdala shapes complex behavioral responses to socially ambiguous cues. We explored human amygdala function during explicit behavioral decision making about discrete emotional facial expressions that can represent socially unambiguous and ambiguous cues. During functional magnetic resonance imaging, 43 healthy adults were required to make complex social decisions (i.e., approach or avoid) about either relatively unambiguous (i.e., angry, fearful, happy) or ambiguous (i.e., neutral) facial expressions. Amygdala activation during this task was compared with that elicited by simple, perceptual decisions (sex discrimination) about the identical facial stimuli. Angry and fearful expressions were more frequently judged as avoidable and happy expressions most often as approachable. Neutral expressions were equally judged as avoidable and approachable. Reaction times to neutral expressions were longer than those to angry, fearful, and happy expressions during social judgment only. Imaging data on stimuli judged to be avoided revealed a significant task by emotion interaction in the amygdala. Here, only neutral facial expressions elicited greater activity during social judgment than during sex discrimination. Furthermore, during social judgment only, neutral faces judged to be avoided were associated with greater amygdala activity relative to neutral faces that were judged as approachable. Moreover, functional coupling between the amygdala and both dorsolateral prefrontal (social judgment > sex discrimination) and cingulate (sex discrimination > social judgment) cortices was differentially modulated by task during processing of neutral faces. Our results suggest that increased amygdala reactivity and differential functional coupling with prefrontal circuitries may shape complex decisions and behavioral responses to socially ambiguous cues.

Modes of speciation and the neutral theory of biodiversity

NARCIS (Netherlands)

Etienne, R.S.; Apol, M.E.F.; Olff, H.

2007-01-01

Hubbell's neutral theory of biodiversity has generated much debate over the need for niches to explain biodiversity patterns. Discussion of the theory has focused on its neutrality assumption, i.e. the functional equivalence of species in competition and dispersal. Almost no attention has been paid

Modes of speciation and the neutral theory of biodiversity

NARCIS (Netherlands)

Etienne, Rampal S.; Apol, M. Emile F.; Olff, Han; Weissing, Franz J.

Hubbell's neutral theory of biodiversity has generated much debate over the need for niches to explain biodiversity patterns. Discussion of the theory has focused on its neutrality assumption, i.e. the functional equivalence of species in competition and dispersal. Almost no attention has been paid

Detecting the neutral top-pion at e+e- colliders

International Nuclear Information System (INIS)

Wang Xuelei; Yang Yueling; Li Bingzhong

2004-01-01

We investigate some processes of the associated production of a neutral top-pion Π t 0 with a pair of fermions (e + e - →ff-barΠ t 0 ) in the context of top-color-assisted technicolor (TC2) theory in the future e + e - colliders. The studies show that the largest cross sections of the processes e + e - →f ' f ' Π t 0 (f ' =u,d,c,s,μ,τ) could only reach the level of 0.01 fb; we can hardly detect a neutral top-pion through these processes. For the processes e + e - →e + e - Π t 0 , e + e - →tt-barΠ t 0 , and e + e - →bb-barΠ t 0 , the cross sections of these processes are at the level of a few fb for the favorable parameters, and a few tens, even hundreds, of neutral top-pion events can be produced at future e + e - colliders each year through these processes. With the clean background of the flavor-changing tc-bar channel, the top-pion events can possibly be detected at the planned high luminosity e + e - colliders. Therefore, such neutral top-pion production processes provide a useful way to detect a neutral top-pion and test the TC2 model directly

A non-equilibrium neutral model for analysing cultural change.

Science.gov (United States)

Kandler, Anne; Shennan, Stephen

2013-08-07

Neutral evolution is a frequently used model to analyse changes in frequencies of cultural variants over time. Variants are chosen to be copied according to their relative frequency and new variants are introduced by a process of random mutation. Here we present a non-equilibrium neutral model which accounts for temporally varying population sizes and mutation rates and makes it possible to analyse the cultural system under consideration at any point in time. This framework gives an indication whether observed changes in the frequency distributions of a set of cultural variants between two time points are consistent with the random copying hypothesis. We find that the likelihood of the existence of the observed assemblage at the end of the considered time period (expressed by the probability of the observed number of cultural variants present in the population during the whole period under neutral evolution) is a powerful indicator of departures from neutrality. Further, we study the effects of frequency-dependent selection on the evolutionary trajectories and present a case study of change in the decoration of pottery in early Neolithic Central Europe. Based on the framework developed we show that neutral evolution is not an adequate description of the observed changes in frequency. Copyright © 2013 Elsevier Ltd. All rights reserved.

2017 AMcard prn.pmd

Indian Academy of Sciences (India)

Administrator

2017-11-03

Nov 3, 2017 ... Chairperson: M M Sarin, Physical Research laboratory, Ahmedabad. 1200–1220 Shailesh Nayak, Ministry of Earth Sciences, New Delhi. Towards the understanding of triggered earthquakes. 1225–1245 Gobinda Majumder, Tata Institute of Fundamental Research, Mumbai. A journey to the discovery of ...

Efficient simulation and likelihood methods for non-neutral multi-allele models.

Science.gov (United States)

Joyce, Paul; Genz, Alan; Buzbas, Erkan Ozge

2012-06-01

Throughout the 1980s, Simon Tavaré made numerous significant contributions to population genetics theory. As genetic data, in particular DNA sequence, became more readily available, a need to connect population-genetic models to data became the central issue. The seminal work of Griffiths and Tavaré (1994a , 1994b , 1994c) was among the first to develop a likelihood method to estimate the population-genetic parameters using full DNA sequences. Now, we are in the genomics era where methods need to scale-up to handle massive data sets, and Tavaré has led the way to new approaches. However, performing statistical inference under non-neutral models has proved elusive. In tribute to Simon Tavaré, we present an article in spirit of his work that provides a computationally tractable method for simulating and analyzing data under a class of non-neutral population-genetic models. Computational methods for approximating likelihood functions and generating samples under a class of allele-frequency based non-neutral parent-independent mutation models were proposed by Donnelly, Nordborg, and Joyce (DNJ) (Donnelly et al., 2001). DNJ (2001) simulated samples of allele frequencies from non-neutral models using neutral models as auxiliary distribution in a rejection algorithm. However, patterns of allele frequencies produced by neutral models are dissimilar to patterns of allele frequencies produced by non-neutral models, making the rejection method inefficient. For example, in some cases the methods in DNJ (2001) require 10(9) rejections before a sample from the non-neutral model is accepted. Our method simulates samples directly from the distribution of non-neutral models, making simulation methods a practical tool to study the behavior of the likelihood and to perform inference on the strength of selection.

Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains

Directory of Open Access Journals (Sweden)

Narayanaiah Cheedarla

2018-03-01

Full Text Available Strain-specific neutralizing antibodies develop in all human immunodeficiency virus type 1 (HIV-1-infected individuals. However, only 10–30% of infected individuals produce broadly neutralizing antibodies (bNAbs. Identification and characterization of these bNAbs and understanding their evolution dynamics are critical for obtaining useful clues for the development of an effective HIV vaccine. Very recently, we published a study in which we identified 12 HIV-1 subtype C-infected individuals from India whose plasma showed potent and broad cross-clade neutralization (BCN ability (1. In the present study, we report our findings on the evolution of host bNAb response over a period of 4 years in a subset of these individuals. Three of the five individuals (NAB033, NAB059, and NAB065 demonstrated a significant increase (p < 0.05 in potency. Interestingly, two of the three samples also showed a significant increase in CD4 binding site-specific antibody response, maintained stable CD4+ T cell counts (>350 cells/mm3 and continued to remain ART-naïve for more than 10 years after initial diagnosis, implying a strong clinical correlation with the development and evolution of broadly neutralizing antibody response against HIV-1.

Neutral transport calculations for W VII-X. First applications to W VII-X

International Nuclear Information System (INIS)

Sardei, F.

1988-01-01

Results of neutral gas transport calculations obtained with the DEGAS code are presented for a W VII-AS model plasma and a source of neutrals due to limiter recycling. For typical profiles of the plasma parameters as predicted for an ECRH discharge, the simulation yields a radial drop of the average neutral population by a factor of 30. The neutrals are strongly localized near the limiter and have a poloidal minimum at its opposite side. For a W VII-X configuration (HS4-12), a neutral source given by a high recycling ion flux equally distributed over the wall is considered. For an ion density of 5 x 10 1 3 /cc and 30 eV edge temperature, the neutrals originating from the wall completely ionize within the ergodic region. The corresponding average energy of cx neutrals hitting the wall is less than 30 eV. Neutral penetration into the plasma locally depends on the distance between wall and separatrix

Very-high-level neutral-beam control system

International Nuclear Information System (INIS)

Elischer, V.; Jacobson, V.; Theil, E.

1981-10-01

As increasing numbers of neutral beams are added to fusion machines, their operation can consume a significant fraction of a facility's total resources. LBL has developed a very high level control system that allows a neutral beam injector to be treated as a black box with just 2 controls: one to set the beam power and one to set the pulse duration. This 2 knob view allows simple operation and provides a natural base for implementing even higher level controls such as automatic source conditioning

Design of cryo-vacuum system for MW neutral beam injector

International Nuclear Information System (INIS)

Hu Chundong; Xie Yuanlai

2010-01-01

Neutral beam injector is an equipment that is used to produce and then to neutralize high energetic particle beam. A neutral beam injector (EAST-NBI) with MW magnitude neutral beam power is considered to be developed to support the EAST physical research. The requirements for vacuum system were analyzed after introducing the principle of EAST-NBI. A differential vacuum system structure was chosen after analyzing the performance of different vacuum pumping system structure. The gas sources and their characteristics were analyzed, and two inserted type cryocondensation pumps were chosen as main vacuum pump. The schematic structure of the two cryocondensation pump with pumping area 8 m 2 and 6 m 2 were given and their cooling method and temperature control mode were determined. (authors)

Methodology guideline. Organization of conference neutral in carbon

International Nuclear Information System (INIS)

2007-01-01

In the framework of the Climate Plan elaborated by the french government, the neutral carbon principle must be applied to conference organization and the international travels. This guide has two main functions: heighten to allow everybody to understand the climate change impacts and problems, and bring some recommendations and tools to implement a neutral carbon conference (transport, welcome, accommodation and meal). (A.L.B.)

Chemical conditions of the Japanese neutral geothermal reservoirs

International Nuclear Information System (INIS)

Chiba, H.

1991-01-01

The aqueous speciation were calculated for fluids of seven Japanese geothermal systems. The aqueous composition as well as CO 2 partial pressure of fluid in neutral pH geothermal reservoir are controlled by silicate, calcite and anhydrite minerals. The chemical composition of neutral pH geothermal reservoir can be predictable if two parameters (e.g. temperature and one of the cation activities) are provided. (author)

Calculation of neutral beam deposition accounting for excited states

International Nuclear Information System (INIS)

Gianakon, T.A.

1992-09-01

Large-scale neutral-beam auxillary heating of plasmas has led to new plasma operational regimes which are often dominated by fast ions injected via the absorption of an energetic beam of hydrogen neutrals. An accurate simulation of the slowing down and transport of these fast ions requires an intimate knowledge of the hydrogenic neutral deposition on each flux surface of the plasma. As a refinement to the present generation of transport codes, which base their beam deposition on ground-state reaction rates, a new set of routines, based on the excited states of hydrogen, is presented as mechanism for computing the attenuation and deposition of a beam of energetic neutrals. Additionally, the numerical formulations for the underlying atomic physics for hydrogen impacting on the constiuent plasma species is developed and compiled as a numerical database. Sample results based on this excited state model are compared with the ground-state model for simple plasma configurations

Confinement of a neutral plasma using nested electric potential wells

International Nuclear Information System (INIS)

Ordonez, C.A.

1997-01-01

A self-consistent, two-dimensional analysis is presented on confining a region of neutral plasma with a Penning/Malmberg type plasma trap using a nested well configuration. It is found that a neutral plasma region having disparate electron and ion temperatures or having high charge state ions can be confined with static fields. For confining a neutral region comprised of electrons and equal temperature low charge state ions, a quasistatic approach appears promising. copyright 1997 American Institute of Physics

Influence of nonlinear effects on the neutral gas transport in tokamaks

International Nuclear Information System (INIS)

Behringer, T.

1992-06-01

The linear Monte Carlo computer code EIRENE for calculation of free molecular flow of neutral gases through a background plasma has been extended to the non-linear transition flow regime (Knudsen number 0.1-10). Motivation arose from higher gas densities in the range of 10 13 -10 15 cm -3 appearing in the srape-off layer and in parts of the vacuum system of advanced tokamak experiments. To treat the problem, the Direct Monte Carlo Simulation Method after Bird, a kinetic approach, was chosen, since the conditions for application of continuum theory are not met. First results with the extended code were obtained in calculating the conductance of plasma-free short cylindrical ducts and elbows. A steady increase in conductance with decreasing Knudsen number was found, which is in good agreement with experimental data. Further calculations for transition flows through fixed background plasmas were made. In these, solutions obtained were represented as differences from solutions obtained by linear calculations. Simulation of a 1-D plasma slab configuration (related to the gaseous divertor concept) revealed markedly varying neutral gas profiles due to neutral-neutral collisions. In addition, in these runs neutral-neutral inelastic collision processes turned out to be negligible. Finally, neutral gas behaviour at higher densities in pump limiter geometries was studied, related to experiments on the tokamak TEXTOR. An increase in conductance in the direction to the pumps of up to 25% relative to linear results was found. Recently obtained experimental data on the impact of non-linear neutral effects upon conductance could be confirmed. (orig.) [de

The Net Neutrality Debate: Analysis of economic implications of net neutrality on internet service providers, content providers and internet users

OpenAIRE

Møinichen, Jørgen

2014-01-01

This thesis studies the economic implications of a transition from a neutral to a non-neutral network. A mathematical model with an end to end ecosystem is developed, which includes a backbone internet service provider that provides connectivity for the content providers. The model also includes internet users that pay an access internet service provider for connectivity to interact with the content providers, advertisers that pay the content providers, and access internet service providers t...

Identifying Activity Descriptors for CO2 Electro-Reduction to Methanol on Rutile (110) Surfaces

DEFF Research Database (Denmark)

Bhowmik, Arghya; Hansen, Heine Anton; Vegge, Tejs

2015-01-01

Electrocatalytic reduction of CO2 to liquid fuels using energy from renewable sources has the potential to form the basis of a carbon neutral sustainable energy system, while integrating seamlessly in the established infrastructure1. Storing intermittent renewable energy in a chemical fuel...... towards electrocatalytic production of methanol. We would like to acknowledge the Lundbeck Foundation for financial support of this work. References: 1. Lewis, N. S. & Nocera, D. G. Powering the planet: chemical challenges in solar energy utilization. Proc. Natl. Acad. Sci. U. S. A.103,15729–35 (2006......., Ali, I., Jansen, M. & Omanovic, S. Electrochemical reduction of CO 2 in an aqueous electrolyte employing an iridium/ruthenium-oxide electrode. Can. J. Chem. Eng. (2014). doi:10.1002/cjce.22110 6. Nørskov, J. K. et al. Origin of the Overpotential for Oxygen Reduction at a Fuel-Cell Cathode. J. Phys...

Antiviral Therapy by HIV-1 Broadly Neutralizing and Inhibitory Antibodies

Directory of Open Access Journals (Sweden)

Zhiqing Zhang

2016-11-01

Full Text Available Human immunodeficiency virus type 1 (HIV-1 infection causes acquired immune deficiency syndrome (AIDS, a global epidemic for more than three decades. HIV-1 replication is primarily controlled through antiretroviral therapy (ART but this treatment does not cure HIV-1 infection. Furthermore, there is increasing viral resistance to ART, and side effects associated with long-term therapy. Consequently, there is a need of alternative candidates for HIV-1 prevention and therapy. Recent advances have discovered multiple broadly neutralizing antibodies against HIV-1. In this review, we describe the key epitopes on the HIV-1 Env protein and the reciprocal broadly neutralizing antibodies, and discuss the ongoing clinical trials of broadly neutralizing and inhibitory antibody therapy as well as antibody combinations, bispecific antibodies, and methods that improve therapeutic efficacy by combining broadly neutralizing antibodies (bNAbs with latency reversing agents. Compared with ART, HIV-1 therapeutics that incorporate these broadly neutralizing and inhibitory antibodies offer the advantage of decreasing virus load and clearing infected cells, which is a promising prospect in HIV-1 prevention and treatment.

Lifetimes of charged and neutral B hadrons using event topology

CERN Document Server

Adam, W; Agasi, E; Ajinenko, I; Aleksan, Roy; Alekseev, G D; Allport, P P; Almehed, S; Alvsvaag, S J; Amaldi, Ugo; Amato, S; Andreazza, A; Andrieux, M L; Antilogus, P; Anykeyev, V B; Apel, W D; Arnoud, Y; Åsman, B; Augustin, J E; Augustinus, A; Baillon, Paul; Bambade, P; Barão, F; Barate, R; Bardin, Dimitri Yuri; Barker, G J; Baroncelli, A; Bärring, O; Barrio, J A; Bartl, Walter; Bates, M J; Battaglia, Marco; Baubillier, M; Baudot, J; Becks, K H; Begalli, M; Beillière, P; Belokopytov, Yu A; Benvenuti, Alberto C; Berggren, M; Bertrand, D; Bianchi, F; Bigi, M; Bilenky, S M; Billoir, P; Bloch, D; Blume, M; Blyth, S; Bocci, V; Bolognese, T; Bonesini, M; Bonivento, W; Booth, P S L; Borisov, G; Bosio, C; Bosworth, S; Botner, O; Bouquet, B; Bourdarios, C; Bowcock, T J V; Bozzo, M; Branchini, P; Brand, K D; Brenner, R A; Bricman, C; Brillault, L; Brown, R C A; Brückman, P; Brunet, J M; Bugge, L; Buran, T; Buys, A; Caccia, M; Calvi, M; Camacho-Rozas, A J; Camporesi, T; Canale, V; Canepa, M; Cankocak, K; Cao, F; Carena, F; Carrilho, P; Carroll, L; Caso, Carlo; Castillo-Gimenez, M V; Cattai, A; Cavallo, F R; Cerrito, L; Chabaud, V; Charpentier, P; Chaussard, L; Chauveau, J; Checchia, P; Chelkov, G A; Chierici, R; Chliapnikov, P V; Chochula, P; Chorowicz, V; Cindro, V; Collins, P; Contreras, J L; Contri, R; Cortina, E; Cosme, G; Cossutti, F; Crawley, H B; Crennell, D J; Crosetti, G; Cuevas-Maestro, J; Czellar, S; Dahl-Jensen, Erik; Dahm, J; D'Almagne, B; Dam, M; Damgaard, G; Daum, A; Dauncey, P D; Davenport, Martyn; Da Silva, W; Defoix, C; Della Ricca, G; Delpierre, P A; Demaria, N; De Angelis, A; De Boeck, H; de Boer, Wim; De Brabandere, S; De Clercq, C; La Vaissière, C de; De Lotto, B; De Min, A; De Paula, L S; De Saint-Jean, C; Dijkstra, H; Di Ciaccio, Lucia; Djama, F; Dolbeau, J; Dönszelmann, M; Doroba, K; Dracos, M; Drees, J; Drees, K A; Dris, M; Dufour, Y; Dupont, F; Edsall, D M; Ehret, R; Eigen, G; Ekelöf, T J C; Ekspong, Gösta; Elsing, M; Engel, J P; Ershaidat, N; Erzen, B; Espirito-Santo, M C; Falk, E; Fassouliotis, D; Feindt, Michael; Ferrer, A; Filippas-Tassos, A; Firestone, A; Fischer, P A; Föth, H; Fokitis, E; Fontanelli, F; Formenti, F; Franek, B J; Frenkiel, P; Fries, D E C; Frodesen, A G; Frühwirth, R; Fulda-Quenzer, F; Fürstenau, H; Fuster, J A; Galloni, A; Gamba, D; Gandelman, M; García, C; García, J; Gaspar, C; Gasparini, U; Gavillet, P; Gazis, E N; Gelé, D; Gerber, J P; Gibbs, M; Gillespie, D; Gokieli, R; Golob, B; Gopal, Gian P; Gorn, L; Górski, M; Guz, Yu; Gracco, Valerio; Graziani, E; Grosdidier, G; Gunnarsson, P; Günther, M; Guy, J; Haedinger, U; Hahn, F; Hahn, M; Hahn, S; Hajduk, Z; Hallgren, A; Hamacher, K; Hao, W; Harris, F J; Hedberg, V; Henriques, R P; Hernández, J J; Herquet, P; Herr, H; Hessing, T L; Higón, E; Hilke, Hans Jürgen; Hill, T S; Holmgren, S O; Holt, P J; Holthuizen, D J; Houlden, M A; Hrubec, Josef; Huet, K; Hultqvist, K; Ioannou, P; Jackson, J N; Jacobsson, R; Jalocha, P; Janik, R; Jarlskog, G; Jarry, P; Jean-Marie, B; Johansson, E K; Jönsson, L B; Jönsson, P E; Joram, Christian; Juillot, P; Kaiser, M; Kalmus, George Ernest; Kapusta, F; Karlsson, M; Karvelas, E; Katsanevas, S; Katsoufis, E C; Keränen, R; Khomenko, B A; Khovanskii, N N; King, B J; Kjaer, N J; Klein, H; Klovning, A; Kluit, P M; Köhne, J H; Köne, B; Kokkinias, P; Koratzinos, M; Korcyl, K; Kostyukhin, V; Kourkoumelis, C; Kuznetsov, O; Kramer, P H; Krammer, Manfred; Kreuter, C; Królikowski, J; Kronkvist, I J; Krumshtein, Z; Krupinski, W; Kubinec, P; Kucewicz, W; Kurvinen, K L; Lacasta, C; Laktineh, I; Lamblot, S; Lamsa, J; Lanceri, L; Lane, D W; Langefeld, P; Lapin, V; Last, I; Laugier, J P; Lauhakangas, R; Leder, Gerhard; Ledroit, F; Lefébure, V; Legan, C K; Leitner, R; Lemoigne, Y; Lemonne, J; Lenzen, Georg; Lepeltier, V; Lesiak, T; Liko, D; Lindner, R; Lipniacka, A; Lippi, I; Lörstad, B; Lokajícek, M; Loken, J G; López, J M; López-Fernandez, A; López-Aguera, M A; Loukas, D; Lutz, P; Lyons, L; MacNaughton, J N; Maehlum, G; Maio, A; Malychev, V; Mandl, F; Marco, J; Maréchal, B; Margoni, M; Marin, J C; Mariotti, C; Markou, A; Maron, T; Martínez-Rivero, C; Martínez-Vidal, F; Martí i García, S; Matorras, F; Matteuzzi, C; Matthiae, Giorgio; Mazzucato, M; McCubbin, M L; McKay, R; McNulty, R; Medbo, J; Meroni, C; Meyer, W T; Michelotto, M; Migliore, E; Mirabito, L; Mitaroff, Winfried A; Mjörnmark, U; Moa, T; Møller, R; Mönig, K; Monge, M R; Morettini, P; Müller, H; Mundim, L M; Murray, W J; Muryn, B; Myatt, Gerald; Naraghi, F; Navarria, Francesco Luigi; Navas, S; Negri, P; Némécek, S; Neumann, W; Neumeister, N; Nicolaidou, R; Nielsen, B S; Nieuwenhuizen, M; Nikolaenko, V; Niss, P; Nomerotski, A; Normand, Ainsley; Oberschulte-Beckmann, W; Obraztsov, V F; Olshevskii, A G; Onofre, A; Orava, Risto; Österberg, K; Ouraou, A; Paganini, P; Paganoni, M; Pagès, P; Palka, H; Papadopoulou, T D; Pape, L; Parkes, C; Parodi, F; Passeri, A; Pegoraro, M; Peralta, L; Pernegger, H; Pernicka, Manfred; Perrotta, A; Petridou, C; Petrolini, A; Phillips, H T; Piana, G; Pierre, F; Pimenta, M; Plaszczynski, S; Podobrin, O; Pol, M E; Polok, G; Poropat, P; Pozdnyakov, V; Prest, M; Privitera, P; Pukhaeva, N; Pullia, Antonio; Radojicic, D; Ragazzi, S; Rahmani, H; Rames, J; Ratoff, P N; Read, A L; Reale, M; Rebecchi, P; Redaelli, N G; Regler, Meinhard; Reid, D; Renton, P B; Resvanis, L K; Richard, F; Richardson, J; Rídky, J; Rinaudo, G; Ripp, I; Romero, A; Roncagliolo, I; Ronchese, P; Roos, L; Rosenberg, E I; Rosso, E; Roudeau, Patrick; Rovelli, T; Rückstuhl, W; Ruhlmann-Kleider, V; Ruiz, A; Saarikko, H; Sacquin, Yu; Sadovskii, A; Sajot, G; Salt, J; Sánchez, J; Sannino, M; Schneider, H; Schyns, M A E; Sciolla, G; Scuri, F; Sedykh, Yu; Segar, A M; Seitz, A; Sekulin, R L; Shellard, R C; Siccama, I; Siegrist, P; Simonetti, S; Simonetto, F; Sissakian, A N; Sitár, B; Skaali, T B; Smadja, G; Smirnov, N; Smirnova, O G; Smith, G R; Sosnowski, R; Souza-Santos, D; Spassoff, Tz; Spiriti, E; Squarcia, S; Stäck, H; Stanescu, C; Stapnes, Steinar; Stavitski, I; Stepaniak, K; Stichelbaut, F; Stocchi, A; Strub, R; Stugu, B; Szczekowski, M; Szeptycka, M; Tabarelli de Fatis, T; Tavernet, J P; Chikilev, O G; Tilquin, A; Timmermans, J; Tkatchev, L G; Todorov, T; Toet, D Z; Tomaradze, A G; Tomé, B; Tortora, L; Tranströmer, G; Treille, D; Trischuk, W; Tristram, G; Trombini, A; Troncon, C; Tsirou, A L; Turluer, M L; Tyapkin, I A; Tyndel, M; Tzamarias, S; Überschär, B; Überschär, S; Ullaland, O; Uvarov, V; Valenti, G; Vallazza, E; van Apeldoorn, G W; van Dam, P; Van Doninck, W K; Van Eldik, J; Vassilopoulos, N; Vegni, G; Ventura, L; Venus, W A; Verbeure, F; Verlato, M; Vertogradov, L S; Vilanova, D; Vincent, P; Vitale, L; Vlasov, E; Vodopyanov, A S; Vrba, V; Wahlen, H; Walck, C; Waldner, F; Wehr, A; Weierstall, M; Weilhammer, Peter; Wetherell, Alan M; Wicke, D; Wickens, J H; Wielers, M; Wilkinson, G R; Williams, W S C; Winter, M; Witek, M; Woschnagg, K; Yip, K; Yushchenko, O P; Zach, F; Zacharatou-Jarlskog, C; Zaitsev, A; Zalewska-Bak, A; Zalewski, Piotr; Zavrtanik, D; Zevgolatakos, E; Zhigunov, V P; Zimin, N I; Zito, M; Zontar, D; Zuberi, R; Zucchelli, G C; Zumerle, G

1995-01-01

The lifetimes of charged and neutral B hadrons have been measured using data collected by the DELPHI experiment at LEP between 1991 and 1993. B hadrons are tagged as jets with a secondary vertex and the charge of the B candidate is taken to be the sum of the charges of the particles in the secondary vertex. Approximately 1,434,000 multihadronic \\PZz decays yielded 1817 B hadron candidates. The B purity was estimated to be around 99.1\\pm0.3\\%, and 83\\% (70\\%) of the events measured as neutral (charged) came from neutral (charged) B's. The mean lifetimes of charged and neutral B hadrons were found to be \\TAUBC\\pm\\ERRBC\\;(stat.)\\pm\\SYSBC\\;(syst.)~ps and \\TAUBN\\pm\\ERRBN\\;(stat.)\\pm\\SYSBN\\;(syst.)~ps respectively. The ratio of their lifetimes, \\tau_{charged}/\\tau_{neutral}, was \\RAT10^{\\ERRCNP}_{\\ERRCNM}\\;(stat.)\\pm\\SYSR10\\;(syst.). By making assumptions about the \\PsB and \\PlB states, the \\PbBp and \\PbBz meson lifetimes were determined to be \\tau_{{\\rm B}^+}=\\TAUBP\\pm\\ERRBP\\;(stat.)\\pm\\ SYSBP\\;(syst.)~ps and \\tau...

Three-dimensional modeling of the neutral gas depletion effect in a helicon discharge plasma

Science.gov (United States)

Kollasch, Jeffrey; Schmitz, Oliver; Norval, Ryan; Reiter, Detlev; Sovinec, Carl

2016-10-01

Helicon discharges provide an attractive radio-frequency driven regime for plasma, but neutral-particle dynamics present a challenge to extending performance. A neutral gas depletion effect occurs when neutrals in the plasma core are not replenished at a sufficient rate to sustain a higher plasma density. The Monte Carlo neutral particle tracking code EIRENE was setup for the MARIA helicon experiment at UW Madison to study its neutral particle dynamics. Prescribed plasma temperature and density profiles similar to those in the MARIA device are used in EIRENE to investigate the main causes of the neutral gas depletion effect. The most dominant plasma-neutral interactions are included so far, namely electron impact ionization of neutrals, charge exchange interactions of neutrals with plasma ions, and recycling at the wall. Parameter scans show how the neutral depletion effect depends on parameters such as Knudsen number, plasma density and temperature, and gas-surface interaction accommodation coefficients. Results are compared to similar analytic studies in the low Knudsen number limit. Plans to incorporate a similar Monte Carlo neutral model into a larger helicon modeling framework are discussed. This work is funded by the NSF CAREER Award PHY-1455210.

Pyrrolnitrin and Hydrogen Cyanide Production by Pseudomonas chlororaphis Strain PA23 Exhibits Nematicidal and Repellent Activity against Caenorhabditis elegans.

Directory of Open Access Journals (Sweden)

Munmun Nandi

Full Text Available Pseudomonas chlororaphis strain PA23 is a biocontrol agent able to suppress growth of the fungal pathogen Sclerotinia sclerotiorum. This bacterium produces an arsenal of exometabolites including pyrrolnitrin (PRN, phenazine (PHZ, hydrogen cyanide (HCN, and degradative enzymes. Production of these compounds is controlled at both the transcriptional and posttranscriptional levels by the Gac-Rsm system, RpoS, PsrA, and the Phz quorum-sensing system. Beyond pathogen-suppression, the success of a biocontrol agent is dependent upon its ability to establish itself in the environment where predation by bacterivorous organisms, including nematodes, may threaten persistence. The focus of this study was to investigate whether PA23 is able to resist grazing by Caenorhabditis elegans and to define the role played by exoproducts in the bacterial-nematode interaction. We discovered that both PRN and HCN contribute to fast- and slow-killing of C. elegans. HCN is well-established as having lethal effects on C. elegans; however, PRN has not been reported to be nematicidal. Exposure of L4 stage nematodes to purified PRN reduced nematode viability in a dose-dependent fashion and led to reduced hatching of eggs laid by gravid adults. Because bacterial metabolites can act as chemoattractants or repellents, we analyzed whether PA23 exhibited attractant or repulsive properties towards C. elegans. Both PRN and HCN were found to be potent repellents. Next we investigated whether the presence of C. elegans would elicit changes in PA23 gene activity. Co-culturing the two organisms increased expression of a number of genes associated with biocontrol, including phzA, hcnA, phzR, phzI, rpoS and gacS. Exoproduct analysis showed that PHZ and autoinducer signals were upregulated, consistent with the gene expression profiles. Collectively, these findings indicate that PA23 is able to sense the presence of C. elegans and it is able to both repel and kill the nematodes, which

Production and reduction of nitrous oxide in agricultural and forest soils.

Science.gov (United States)

Yu, K; Chen, G; Struwe, S; Kjøller, A

2000-06-01

A soil-water slurry experiment was conducted to study the potentials of N2O production and reduction in denitrification of agricultural and beech forest soils in Denmark. The effects of nitrate and ammonium additions on denitrification were also investigated. The forest soil showed a higher denitrification potential than the agricultural soil. However, N2O reduction potential of the agricultural soil was higher than the beech forest soil, shown by the ratio of N2O/N2 approximately 0.11 and 3.65 in the agricultural and the beech forest soils, respectively. Both nitrate and ammonium additions stimulated the N2O production in the two soils, but reduced the N2O reduction rates in the agricultural soil slurries. In contrast to the effect on the agricultural soil, nitrate reduced the N2O reduction rate in the beech forest soil, while ammonium showed a stimulating effect on the N2O reduction activity. After one week incubation, all of the N2O produced was reduced to N2 in the agricultural soil when nitrate was still present. Nitrous oxide reduction in the beech forest soil occurred only when nitrate almost disappeared. The different nitrate inhibitory effect on the N2O reduction activity in the two soils was due to the difference in soil pH. Inhibition of nitrate on N2O reduction was significant under acidic condition. Consequently, soil could serve as a sink of atmospheric N2O under the conditions of anaerobic, pH near neutral and low nitrate content.

Five second helium neutral beam injection using argon-frost cryopumping techniques

International Nuclear Information System (INIS)

Phillips, J.C.; Kellman, D.H.; Hong, R.; Kim, J.; Laughon, G.M.

1995-10-01

High power helium neutral beams for the heating of tokamak discharges can now be provided for 5 s by using argon cryopumping (of the helium gas) in the beamlines. A system has now been installed to deposit a layer of argon frost on the DIII-D neutral beam cryopanels, between tokamak injection pulses. The layer serves to trap helium on the cryopanels providing sufficient pumping speed for 5 s helium beam extraction. The argon frosting hardware is now present on two of four DIII-D neutral beamlines, allowing injection of up to 6 MW of helium neutral beams per discharge, with pulse lengths of up to 5 s. The argon frosting system is described, along with experimental results demonstrating its effectiveness as a method of economically extending the capabilities of cryogenic pumping panels to allow multi-second helium neutral beam injection

Experimental evidence of energetic neutrals production in an ion diode

Energy Technology Data Exchange (ETDEWEB)

Pushkarev, A.I., E-mail: aipush@mail.ru; Isakova, Y.I.; Khaylov, I.P.

2015-01-15

The paper presents several experimental proofs of the formation of energetic charge-exchange neutrals in a self-magnetically insulated ion diode with a graphite cathode. The energetic neutrals are thought to be produced as a result of charge exchange process between accelerated ions and stationary neutral molecules. The experiments have been carried out using both a diode with externally applied magnetic insulation (single-pulse mode: 100 ns, 250–300 kV) and a diode with self-magnetic insulation (double-pulse mode: 300–500 ns, 100–150 kV (negative pulse); 120 ns, 250–300 kV (positive pulse)). The motivation for looking at the neutral component of the ion beam came when we compared two independent methods to measure the energy density of the beam. A quantitative comparison of infrared measurements with signals from Faraday cups and diode voltage was made to assess the presence of neutral atoms in the ion beam. As another proof of charge-exchange effects in ion diode we present the results of statistical analysis of diode performance. It was found that the shot-to shot variation of the energy density in a set of 50–100 shots does not exceed 11%, whilst the same variation for ion current density was 20–30%; suggesting the presence of neutrals in the beam. Moreover, the pressure in the zone of ion beam energy dissipation exceeds the results stated in cited references. The difference between our experimental data and results stated by other authors we attribute to the presence of a low-energy charge-exchange neutral component in the ion beam.

Simplified Stability Criteria for Delayed Neutral Systems

Directory of Open Access Journals (Sweden)

Xinghua Zhang

2014-01-01

Full Text Available For a class of linear time-invariant neutral systems with neutral and discrete constant delays, several existing asymptotic stability criteria in the form of linear matrix inequalities (LMIs are simplified by using matrix analysis techniques. Compared with the original stability criteria, the simplified ones include fewer LMI variables, which can obviously reduce computational complexity. Simultaneously, it is theoretically shown that the simplified stability criteria and original ones are equivalent; that is, they have the same conservativeness. Finally, a numerical example is employed to verify the theoretic results investigated in this paper.

Low energy neutral particle fluxes in the JET divertor

International Nuclear Information System (INIS)

Reichle, R.; Horton, L.D.; Ingesson, L.C.; Jaeckel, H.J.; McCormick, G.K.; Loarte, A.; Simonini, R.; Stamp, M.F.

1997-01-01

First measurements are presented of the total power loss through neutral particles and their average energy in the JET divertor. The method used distinguishes between the heat flux and the electromagnetic radiation on bolometers. This is done by comparing measurements from inside the divertor either with opposite lines of sight or with a tomographic reconstruction of the radiation. The typical value of the total power loss in the divertor through neutrals is about 1 MW. The average energy of the neutral particles at the inner divertor leg is 1.5-3 eV when detachment is in progress, which agrees with EDGE2D/NIMBUS modelling. (orig.)

New stability and stabilization for switched neutral control systems

International Nuclear Information System (INIS)

Xiong Lianglin; Zhong Shouming; Ye Mao; Wu Shiliang

2009-01-01

This paper concerns stability and stabilization issues for switched neutral systems and presents new classes of piecewise Lyapunov functionals and multiple Lyapunov functionals, based on which, two new switching rules are introduced to stabilize the neutral systems. One switching rule is designed from the solution of the so-called Lyapunov-Metzler linear matrix inequalities. The other is based on the determination of average dwell time computed from a new class of linear matrix inequalities (LMIs). And then, state-feedback control is derived for the switched neutral control system mainly based on the state switching rules. Finally, three examples are given to demonstrate the effectiveness of the proposed method.

Application of a CADIS-like variance reduction technique to electron transport

International Nuclear Information System (INIS)

Dionne, B.; Haghighat, A.

2004-01-01

This paper studies the use of approximate deterministic importance functions to calculate the lower-weight bounds of the MCNP5 weight-window variance reduction technique when applied to electron transport simulations. This approach follows the CADIS (Consistent Adjoint Driven Importance Sampling) methodology developed for neutral particles shielding calculations. The importance functions are calculated using the one-dimensional CEPXS/ONELD code package. Considering a simple 1-D problem, this paper shows that our methodology can produce speedups up to ∼82 using an approximate electron importance function distributions computed in ∼8 seconds. (author)

Application of neutral electrolyzed water to disinfection of alginate impression.

Science.gov (United States)

Nagamatsu, Yuki; Chen, Ker-Kong; Nagamatsu, Hiroshi; Kozono, Yoshio; Shimizu, Hiroshi

2016-01-01

Neutral electrolyzed water was developed with new concepts of long-term good durability and minimum corrosiveness to metal in addition to its excellent bactericidal activities similar to acid type of electrolyzed waters. The present study examined the bactericidal effects of the neutral electrolyzed water on disinfection of the alginate impression of a dental arch model contaminated by bacteria. Only 1-min immersion in neutral electrolyzed water could sufficiently disinfect the alginate impression including the metallic tray under ultrasonic with no significant differences from acid electrolyzed waters. No bactericidal effects were found in any electrolyzed water when used as mixing water. Considering the advantages and disadvantages of each electrolyzed water in a comprehensive way, it was suggested that neutral electrolyzed water may be the most appropriate for the disinfection of alginate impression.

Neutral beam injector for 475 keV MARS sloshing ions

International Nuclear Information System (INIS)

Goebel, D.M.; Hamilton, G.W.

1983-01-01

A neutral beam injector system which produces 5 MW of 475 keV D 0 neutrals continuously on target has been designed. The beamline is intended to produce the sloshing ion distribution required in the end plug region of the conceptual MARS tandem mirror commercial reactor. The injector design utilizes the LBL self-extraction negative ion source and Transverse Field Focusing (TFF) accelerator to generate a long, ribbon ion beam. A laser photodetachment neutralizer strips over 90% of the negative ions. Magnetic and neutron shield designs are included to exclude the fringe fields of the end plug and provide low activation by the neutron flux from the target plasma. The use of a TFF accelerator and photodetachment neutralizer produces a total system electrical efficiency of about 63% for this design

The Columbia Non-neutral Torus

International Nuclear Information System (INIS)

Pedersen, Thomas Sunn

2009-01-01

Final report for the Columbia Non-neutral Torus. This details the results from the design, construction and initial operation of the Columbia Non-neutral Torus. During the duration of this grant, I designed, built, and operated the Columbia Nonneutral Torus, the world's lowest aspect ratio stellarator, and arguably, the world's simplest stellarator. This demonstrates the ease and robustness of the chosen stellarator design and allowed us to commence the investigation of the physics of non-neutral plasmas confined on magnetic surfaces. These plasmas are unique in many ways and had not previously been studied in a stellarator. Our first results showed that it is possible to confine and study a relatively cold pure electron plasma in a stellarator. We confirmed that the plasma is stable, and that the plasma is reasonably well confined in a stellarator configuration. These results were published in Physics of Plasmas (2006) and Physical Review Letters (2006). They enabled the existing program which is resolving the underlying transport processes in a classical stellarator with intense self-electric fields and enable the next phase of operation, electron-positron plasma physics. During the period of this grant, two students were trained in experimental plasma physics and both received their PhD degrees shortly after the grant terminated. One student is now employed in the financial services industry, the other is a postdoctoral associate at Los Alamos National Laboratory. The chief goals were to build and begin operation of the Columbia Non-neutral Torus. These goals were achieved in the third year of funding. The development of diagnostic methods and the confirmation of stable equilibria were also achieved during the grant period. In summary, the main scientific goals were all met. The main educational goals were also met, as the experiment became the training ground not only for the two aforementioned graduate students but also for a number of undergraduate students

High-Latitude Neutral Mass Density Maxima

Science.gov (United States)

Huang, C. Y.; Huang, Y.; Su, Y.-J.; Huang, T.; Sutton, E. K.

2017-10-01

Recent studies have reported that thermospheric effects due to solar wind driving can be observed poleward of auroral latitudes. In these papers, the measured neutral mass density perturbations appear as narrow, localized maxima in the cusp and polar cap. They conclude that Joule heating below the spacecraft is the cause of the mass density increases, which are sometimes associated with local field-aligned current structures, but not always. In this paper we investigate neutral mass densities measured by accelerometers on the CHAllenging Minisatellite Payload (CHAMP) and Gravity Recovery and Climate Experiment (GRACE) spacecraft from launch until years 2010 (CHAMP) and 2012 (GRACE), approximately 10 years of observations from each satellite. We extract local maxima in neutral mass densities over the background using a smoothing window with size of one quarter of the orbit. The maxima have been analyzed for each year and also for the duration of each set of satellite observations. We show where they occur, under what solar wind conditions, and their relation to magnetic activity. The region with the highest frequency of occurrence coincides approximately with the cusp and mantle, with little direct evidence of an auroral zone source. Our conclusions agree with the "hot polar cap" observations that have been reported and studied in the past.

Foundational errors in the Neutral and Nearly-Neutral theories of evolution in relation to the Synthetic Theory: is a new evolutionary paradigm necessary?

Science.gov (United States)

Valenzuela, Carlos Y

2013-01-01

The Neutral Theory of Evolution (NTE) proposes mutation and random genetic drift as the most important evolutionary factors. The most conspicuous feature of evolution is the genomic stability during paleontological eras and lack of variation among taxa; 98% or more of nucleotide sites are monomorphic within a species. NTE explains this homology by random fixation of neutral bases and negative selection (purifying selection) that does not contribute either to evolution or polymorphisms. Purifying selection is insufficient to account for this evolutionary feature and the Nearly-Neutral Theory of Evolution (N-NTE) included negative selection with coefficients as low as mutation rate. These NTE and N-NTE propositions are thermodynamically (tendency to random distributions, second law), biotically (recurrent mutation), logically and mathematically (resilient equilibria instead of fixation by drift) untenable. Recurrent forward and backward mutation and random fluctuations of base frequencies alone in a site make life organization and fixations impossible. Drift is not a directional evolutionary factor, but a directional tendency of matter-energy processes (second law) which threatens the biotic organization. Drift cannot drive evolution. In a site, the mutation rates among bases and selection coefficients determine the resilient equilibrium frequency of bases that genetic drift cannot change. The expected neutral random interaction among nucleotides is zero; however, huge interactions and periodicities were found between bases of dinucleotides separated by 1, 2... and more than 1,000 sites. Every base is co-adapted with the whole genome. Neutralists found that neutral evolution is independent of population size (N); thus neutral evolution should be independent of drift, because drift effect is dependent upon N. Also, chromosome size and shape as well as protein size are far from random.

Neutral Models with Generalised Speciation

NARCIS (Netherlands)

Haegeman, Bart; Etienne, Rampal S.

Hubbell's neutral theory claims that ecological patterns such as species abundance distributions can be explained by a stochastic model based on simple assumptions. One of these assumptions, the point mutation assumption, states that every individual has the same probability to speciate. Etienne et

Doublet III neutral beam multi-stream command language system

International Nuclear Information System (INIS)

Campbell, L.; Garcia, J.R.

1983-01-01

A multi-stream command language system was developed to provide control of the dual source neutral beam injectors on the Doublet III experiment at GA Technologies Inc. The Neutral Beam command language system consists of three parts: compiler, sequencer, and interactive task. The command language, which was derived from the Doublet III tokamak command language, POPS, is compiled, using a recursive descent compiler, into reverse polish notation instructions which then can be executed by the sequencer task. The interactive task accepts operator commands via a keyboard. The interactive task directs the operation of three input streams, creating commands which are then executed by the sequencer. The streams correspond to the two sources within a Doublet III neutral beam, plus an interactive stream. The sequencer multiplexes the execution of instructions from these three streams. The instructions include reads and writes to an operator terminal, arithmetic computations, intrinsic functions such as CAMAC input and output, and logical instructions. The neutral beam command language system was implemented using Modular Computer Systems (ModComp) Pascal and consists of two tasks running on a ModComp Classic IV computer. The two tasks, the interactive and the sequencer, run independently and communicate using shared memory regions. The compiler runs as an overlay to the interactive task when so directed by operator commands. The system is succesfully being used to operate the three neutral beams on Doublet III

Neutral atom traps of radioactives

International Nuclear Information System (INIS)

Behr, J.A.

2003-01-01

Neutral atoms trapped with modern laser cooling techniques offer the promise of improving several broad classes of experiments with radioactive isotopes. In nuclear β decay, neutrino spectroscopy from beta-recoil coincidences, along with highly polarized samples, enable experiments to search for non-Standard Model interactions, test whether parity symmetry is maximally violated, and search for new sources of time reversal violation. Ongoing efforts at TRIUMF, Los Alamos and Berkeley will be highlighted. The traps also offer bright sources for Doppler-free spectroscopy, particularly in high-Z atoms where precision measurements could measure the strength of weak neutral nucleon-nucleon and electron-nucleon interactions. Physics with francium atoms has been vigorously pursued at Stony Brook. Several facilities plan work with radioactive atom traps; concrete plans and efforts at KVI Groningen and Legnaro will be among those summarized. Contributions to the multidisciplinary field of trace analysis will be left up to other presenters

Neutral atom traps of radioactives

CERN Document Server

Behr, J A

2003-01-01

Neutral atoms trapped with modern laser cooling techniques offer the promise of improving several broad classes of experiments with radioactive isotopes. In nuclear beta decay, neutrino spectroscopy from beta-recoil coincidences, along with highly polarized samples, enable experiments to search for non-Standard Model interactions, test whether parity symmetry is maximally violated, and search for new sources of time reversal violation. Ongoing efforts at TRIUMF, Los Alamos and Berkeley will be highlighted. The traps also offer bright sources for Doppler-free spectroscopy, particularly in high-Z atoms where precision measurements could measure the strength of weak neutral nucleon-nucleon and electron-nucleon interactions. Physics with francium atoms has been vigorously pursued at Stony Brook. Several facilities plan work with radioactive atom traps; concrete plans and efforts at KVI Groningen and Legnaro will be among those summarized. Contributions to the multidisciplinary field of trace analysis will be left...