WorldWideScience

Sample records for reduced reporting requirements

  1. Report: EPA Office of Inspector General’s Report on Reducing Fraud, Waste, and Abuse in the Small Business Innovative Research Program, as Required by the National Defense Authorization Act for Fiscal Year 2012, Pub. L. 112-81 (2012)

    Science.gov (United States)

    September 28, 2012. The EPA OIG is required by Section 5143 of the NDA Act for Fiscal Year 201 2, Pub. L. No. 112-81 (2012), to report on reducing vulnerability to fraud, waste and abuse in the Small Business Innovative Research (SBIR) program.

  2. Delay generation methods with reduced memory requirements

    DEFF Research Database (Denmark)

    Tomov, Borislav Gueorguiev; Jensen, Jørgen Arendt

    2003-01-01

    Modern diagnostic ultrasound beamformers require delay information for each sample along the image lines. In order to avoid storing large amounts of focusing data, delay generation techniques have to be used. In connection with developing a compact beamformer architecture, recursive algorithms were......) For the best parametric approach, the gate count was 2095, the maximum operation speed was 131.9 MHz, the power consumption at 40 MHz was 10.6 mW, and it requires 4 12-bit words for each image line and channel. 2) For the piecewise-linear approximation, the corresponding numbers are 1125 gates, 184.9 MHz, 7...

  3. 40 CFR 63.1354 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... for Hazardous Air Pollutants From the Portland Cement Manufacturing Industry Notification, Reporting... combustion system component inspections conducted within the reporting period as required under §...

  4. 15 CFR 801.9 - Reports required.

    Science.gov (United States)

    2010-01-01

    ..., portfolio management, investment advice, and all other financial investment activities); insurance carriers... requirements and efficient administration of the survey by eliminating unnecessary followup contact. (C... requirement is necessary to ensure compliance with the reporting requirements and efficient administration of...

  5. Authorization basis requirements comparison report

    Energy Technology Data Exchange (ETDEWEB)

    Brantley, W.M.

    1997-08-18

    The TWRS Authorization Basis (AB) consists of a set of documents identified by TWRS management with the concurrence of DOE-RL. Upon implementation of the TWRS Basis for Interim Operation (BIO) and Technical Safety Requirements (TSRs), the AB list will be revised to include the BIO and TSRs. Some documents that currently form part of the AB will be removed from the list. This SD identifies each - requirement from those documents, and recommends a disposition for each to ensure that necessary requirements are retained when the AB is revised to incorporate the BIO and TSRs. This SD also identifies documents that will remain part of the AB after the BIO and TSRs are implemented. This document does not change the AB, but provides guidance for the preparation of change documentation.

  6. 77 FR 16768 - Export Sales Reporting Requirements

    Science.gov (United States)

    2012-03-22

    ... Office of the Secretary 7 CFR Part 20 RIN 0551-AA70 Export Sales Reporting Requirements AGENCY: Office of... frozen box/primal cuts) and distillers dried grain (DDG) to the Export Sales Reporting Requirements, is..., Branch Chief, Export Sales Reporting Branch, Import Policies and Export Reporting Division, Office...

  7. 12 CFR 932.7 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Reporting requirements. 932.7 Section 932.7 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.7 Reporting requirements. Each Bank shall...

  8. 40 CFR 63.1110 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... Control Technology Standards § 63.1110 Reporting requirements. (a) Required reports. Each owner or... should be addressed, if different than the owner or operator. (3) The address (physical location) of the... activity is required to take place. The owner or operator shall include in the request whatever...

  9. 7 CFR 1709.12 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE ASSISTANCE TO HIGH ENERGY COST COMMUNITIES General Requirements § 1709.12 Reporting requirements... follows: (a) A financial status report listing project expenditures by budget category in such form and at... grant agreement is not being met, the report should discuss the problems or delays that may...

  10. 32 CFR 169a.21 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... ACTIVITIES PROGRAM PROCEDURES Reporting Requirements § 169a.21 Reporting requirements. (a) Inventory and... Activities Management Information System (CAMIS) (Report Control Symbol DD-A&T(Q) 1542). (1) The purpose of... Accounting Office (GAO), OSD, and others. The CAMIS is divided into two parts. Part I contains data on...

  11. 40 CFR 63.807 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... Emission Standards for Wood Furniture Manufacturing Operations § 63.807 Reporting requirements. (a) The... months of wood furniture manufacturing operations: (1) The first report shall be submitted 30...

  12. 7 CFR 1170.7 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... storage facility. In calculating the total dollars received or dollars per pound, the reporting entity....” In calculating the total dollars received or dollars per pound, the reporting entity shall not deduct... 7 Agriculture 9 2010-01-01 2009-01-01 true Reporting requirements. 1170.7 Section...

  13. 10 CFR 205.351 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... in paragraphs (a) through (d) of this section. These reporting procedures are mandatory. Entities... system operating condition(s) or other event(s) which in the judgment of the reporting entity could or... 10 Energy 3 2010-01-01 2010-01-01 false Reporting requirements. 205.351 Section 205.351...

  14. Reducing external speedup requirements for input-queued crossbars

    DEFF Research Database (Denmark)

    Berger, Michael Stubert

    2005-01-01

    This paper presents a modified architecture for an input queued switch that reduces external speedup. Maximal size scheduling algorithms for input-buffered crossbars requires a speedup between port card and switch card. The speedup is typically in the range of 2, to compensate for the scheduler...... performance degradation. This implies, that the required bandwidth between port card and switch card is 2 times the actual port speed, adding to cost and complexity. To reduce this bandwidth, a modified architecture is proposed that introduces a small amount of input and output memory on the switch card chip...

  15. Insulin reduces the requirement for serum in Plasmodium falciparum culture

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Tosta

    1984-03-01

    Full Text Available Insulin added to Plasmodium falciparum cultures (0.2 IU/ml reduced the requirement for human serum from ten to five percent. This represents an obvious advantage by its serum-sparing effect and by reducing the chances of using contaminated serum in cultures. The growth-promoting ability of insulin was observed eitherin culture- adapted P. falciparum or in newly-isolated samples.

  16. 40 CFR 59.408 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ...) NATIONAL VOLATILE ORGANIC COMPOUND EMISSION STANDARDS FOR CONSUMER AND COMMERCIAL PRODUCTS National Volatile Organic Compound Emission Standards for Architectural Coatings § 59.408 Reporting requirements. (a... the United States that is producing, packaging, or repackaging any architectural coating subject...

  17. 7 CFR 926.17 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE DATA COLLECTION, REPORTING AND RECORDKEEPING REQUIREMENTS APPLICABLE TO CRANBERRIES NOT SUBJECT TO THE CRANBERRY MARKETING ORDER §...

  18. 40 CFR 141.806 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... Section 141.806 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) NATIONAL PRIMARY DRINKING WATER REGULATIONS Aircraft Drinking Water Rule § 141.806 Reporting... developed the aircraft water system operations and maintenance plan required by § 141.804, and report the...

  19. Smart gun technology requirements preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, D.R.; Brandt, D.J.; Tweet, K.D.

    1995-05-01

    Goal of the Smart Gun Technology project is to eliminate the capability of an unauthorized user from firing a law enforcement officer`s firearm by implementing user-recognizing-and-authorizing surety technologies. This project is funded by the National Institute of Justice. This document reports the projects first objective: to find and document the requirements for a user-recognizing-and-authorizing firearm technology that law enforcement officers will value. This report details the problem of firearm takeaways in law enforcement, the methodology used to develop the law enforcement officers` requirements, and the requirements themselves.

  20. ATLAS Future Framework Requirements Group Report

    CERN Document Server

    The ATLAS collaboration

    2016-01-01

    The Future Frameworks Requirements Group was constituted in Summer 2013 to consider and summarise the framework requirements from trigger and offline for configuring, scheduling and monitoring the data processing software needed by the ATLAS experiment. The principal motivation for such a re-examination arises from the current and anticipated evolution of CPUs, where multiple cores, hyper-threading and wide vector registers require a shift to a concurrent programming model. Such a model requires extensive changes in the current Gaudi/Athena frameworks and offers the opportunity to consider how HLT and offline processing can be better accommodated within the ATLAS framework. This note contains the report of the Future Frameworks Requirements Group.

  1. 32 CFR 516.61 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... PUBLIC RELATIONS LITIGATION Remedies in Procurement Fraud and Corruption § 516.61 Reporting requirements... is requested by PFD, the provisions of DFARS 209.406-3 (48 CFR 209.406-3) will be followed. That... this information to assist them in taking appropriate administrative, contractual, and civil...

  2. 77 FR 37823 - Export Sales Reporting Requirements

    Science.gov (United States)

    2012-06-25

    ... the quantity of the sale transaction, the type and class of commodity, the marketing year of shipment.... Required reportable information includes the quantity, destination, and marketing year of all pork and DDG... issued pursuant to Sec. 20.5 such as class(es) of wheat and rice, or staple length(s) of cotton. Mixed...

  3. 33 CFR 151.65 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ...) POLLUTION VESSELS CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL WASTE, AND... Treaty as it Pertains to Pollution from Ships Garbage Pollution and Sewage § 151.65 Reporting... volume of garbage requiring disposal, if any of the following types of garbage are to be discharged: (a...

  4. 40 CFR 63.830 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Reporting requirements. 63.830 Section 63.830 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for the Printing...

  5. 33 CFR 151.15 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... BALLAST WATER Implementation of MARPOL 73/78 and the Protocol on Environmental Protection to the Antarctic Treaty as it Pertains to Pollution from Ships Oil Pollution § 151.15 Reporting requirements. (a) The... instantaneous rate permitted in §§ 151.10 or 151.13 of this chapter, or NLS in bulk, in 46 CFR 153.1126 or...

  6. 19 CFR 12.121 - Reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... of the importer and Customs broker. Approval and use of a “blanket” certification will be subject to... 19 Customs Duties 1 2010-04-01 2010-04-01 false Reporting requirements. 12.121 Section 12.121 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF...

  7. 15 CFR 806.3 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... be required from among others, U.S. persons which have direct investment abroad, U.S. persons in which foreign persons have direct investment, U.S. intermediaries, and U.S. persons which assist or... OF ECONOMIC ANALYSIS, DEPARTMENT OF COMMERCE DIRECT INVESTMENT SURVEYS § 806.3 Reporting...

  8. 42 CFR 403.510 - Reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Reporting requirements. 403.510 Section 403.510 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Beneficiary Counseling and Assistance Grants § 403.510...

  9. 30 CFR 702.18 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... EXEMPTION FOR COAL EXTRACTION INCIDENTAL TO THE EXTRACTION OF OTHER MINERALS § 702.18 Reporting requirements... cover: (i) Annual production of coal and other minerals and annual revenue derived from coal and other minerals during the preceding 12-month period, and (ii) The cumulative production of coal and other...

  10. 15 CFR 783.1 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... CYCLE-RELATED ACTIVITIES NOT INVOLVING NUCLEAR MATERIALS § 783.1 Reporting requirements. (a) Initial... this part), if you were engaged in any of the civil nuclear fuel cycle-related activities described in... hard-rock mines, including those that were closed down during calendar year 2008, (up to and including...

  11. 42 CFR 411.361 - Reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... to provide the information. Entities must retain the information, and documentation sufficient to... Physicians and Entities Furnishing Designated Health Services § 411.361 Reporting requirements. (a) Basic rule. Except as provided in paragraph (b) of this section, all entities furnishing services for...

  12. Report of the Federal Internetworking Requirements Panel

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-05-31

    The Federal Internetworking Requirements Panel (FIRP) was established by the National Institute of Standards and Technology (NIST) to reassess Federal requirements for open systems networks and to recommend policy on the Government`s use of networking standards. The Panel was chartered to recommend actions which the Federal Government can take to address the short and long-term issues of interworking and convergence of networking protocols--particularly the Internet Protocol Suite (IPS) and Open Systems Interconnection (OSI) protocol suite and, when appropriate, proprietary protocols. The Panel was created at the request of the Office of Management and Budget in collaboration with the Federal Networking Council and the Federal Information Resources Management Policy Council. The Panel`s membership and charter are contained in an appendix to this report.

  13. Premedication with oral Dextromethorphan reduces intra-operative Morphine requirement

    Directory of Open Access Journals (Sweden)

    R Talakoub

    2005-09-01

    Full Text Available Background: Intra-operative pain has adverse effects on hemodynamic parameters. Due to complications of opioids for pain relief, using non-opioids medication is preferred. The purpose of this study was to investigate the effect of oral dextrometorphan premedication on intra-operative Morphine requirement. Methods: After approval of the Ethics committee and informed consent, 40 adult patients who stand in American Society of Anesthesiologists Physical Status I and II, under general anesthesia for elective laparatomy were selected and classified in two equal groups randomly. In group A, oral dextromethorphan (60mg was administered at 10 PM and 6 AM preoperatively. In group B, placebo (dextrose was administered. After induction of general anesthesia and before skin incision, intravenous morphine (0.01 mg/kg was administered. During surgery, when systolic blood pressure or heart rate was increased more than 20% of the preoperative baseline, 0.01 mg/kg morphine was administered. At the end of surgery, the totally prescribed morphine (mg/kg and maximal increase in systolic, diastolic, mean arterial blood pressure and heart rate relative to the baseline values were calculated and statistically compared with student’s t-test. Results: The mean dose of administered morphine during surgery was significantly less in group A than group B (P<0.0001. Also, Maximal increase in systolic, diastolic and mean arterial blood pressure was significantly less in group A (p<0.003, p<0.004, p<0.0001, respectively. There was no significant difference in maximal heart rate increase between two groups (p<0.114. Conclusion: Oral dextromethorphan premedication may decrease intra-operative morphine requirement and reduce maximal increase in systolic and mean arterial blood pressure during surgery. Key words: Dextromethorphan, Morphine, Intra-operative, Premedication Hemodynamic

  14. ASCR/HEP Exascale Requirements Review Report

    CERN Document Server

    Habib, Salman; Gerber, Richard; Antypas, Katie; Riley, Katherine; Williams, Tim; Wells, Jack; Straatsma, Tjerk; Almgren, A; Amundson, J; Bailey, S; Bard, D; Bloom, K; Bockelman, B; Borgland, A; Borrill, J; Boughezal, R; Brower, R; Cowan, B; Finkel, H; Frontiere, N; Fuess, S; Ge, L; Gnedin, N; Gottlieb, S; Gutsche, O; Han, T; Heitmann, K; Hoeche, S; Ko, K; Kononenko, O; LeCompte, T; Li, Z; Lukic, Z; Mori, W; Nugent, P; Ng, C -K; Oleynik, G; O'Shea, B; Padmanabhan, N; Petravick, D; Petriello, F J; Power, J; Qiang, J; Reina, L; Rizzo, T J; Ryne, R; Schram, M; Spentzouris, P; Toussaint, D; Vay, J -L; Viren, B; Wurthwein, F; Xiao, L

    2016-01-01

    This draft report summarizes and details the findings, results, and recommendations derived from the ASCR/HEP Exascale Requirements Review meeting held in June, 2015. The main conclusions are as follows. 1) Larger, more capable computing and data facilities are needed to support HEP science goals in all three frontiers: Energy, Intensity, and Cosmic. The expected scale of the demand at the 2025 timescale is at least two orders of magnitude -- and in some cases greater -- than that available currently. 2) The growth rate of data produced by simulations is overwhelming the current ability, of both facilities and researchers, to store and analyze it. Additional resources and new techniques for data analysis are urgently needed. 3) Data rates and volumes from HEP experimental facilities are also straining the ability to store and analyze large and complex data volumes. Appropriately configured leadership-class facilities can play a transformational role in enabling scientific discovery from these datasets. 4) A c...

  15. 24 CFR 902.33 - Financial reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Financial reporting requirements... Financial reporting requirements. (a) Annual financial report. All PHAs must submit their unaudited and.... The requirement for compliance with the financial reporting requirements of this section begins...

  16. 75 FR 1548 - Insurer Reporting Requirements; List of Insurers Required To File Reports

    Science.gov (United States)

    2010-01-12

    ... management and consulting services pertaining to operating a fleet of motor vehicles and does not provide... CONTACT: Carlita Ballard, Office of International Policy, Fuel Economy and Consumer Programs, NHTSA, 1200... required to report for particular states because each insurer had a 10 percent or greater market share...

  17. Hepatic resection is associated with reduced postoperative opioid requirement

    Directory of Open Access Journals (Sweden)

    Caitlyn Rose Moss

    2016-01-01

    Conclusion: Patients undergoing open hepatic resection had a significantly lower opioid requirement in comparison with patients undergoing open pancreaticoduodenectomy. A multicenter prospective evaluation should be performed to confirm these findings.

  18. 25 CFR 276.8 - Financial reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Financial reporting requirements. 276.8 Section 276.8... ASSISTANCE ACT PROGRAM UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS § 276.8 Financial reporting requirements. Requirements for grantees to report financial information to the Bureau, and to request...

  19. 76 FR 5248 - Insurer Reporting Requirements; Annual Insurer Report on Motor Vehicle Theft for the 2005...

    Science.gov (United States)

    2011-01-28

    ... passenger cars. The Act also addressed several other actions to reduce motor vehicle theft, such as... taken by insurers to assist in deterring thefts. Rental and leasing companies also are required to... leasing company to which this regulation applies must submit a report annually not later than October...

  20. 77 FR 23320 - Insurer Reporting Requirements; Annual Insurer Report on Motor Vehicle Theft for the 2006...

    Science.gov (United States)

    2012-04-18

    ... cars. The Act also addressed several other actions to reduce motor vehicle theft, such as increased... assist in deterring thefts. Rental and leasing companies also are required to provide annual theft reports to the agency. In accordance with 49 CFR 544.5, each insurer, rental and leasing company to...

  1. 40 CFR 63.707 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... § 63.703(c) by performing a material balance calculation in accordance with § 63.705(c)(1) shall report...) shall report the amount of HAP utilized in each 12-month period in an annual report to the Administrator... days after the compliance date; and (2) For new sources, the first report shall include the quantity of...

  2. 46 CFR 232.6 - Financial report filing requirement.

    Science.gov (United States)

    2010-10-01

    ... RELATED ACTIVITIES UNIFORM FINANCIAL REPORTING REQUIREMENTS Income Statement § 232.6 Financial report filing requirement. (a) Reporting Frequency and Due Dates. The contractor shall file a semiannual... 46 Shipping 8 2010-10-01 2010-10-01 false Financial report filing requirement. 232.6 Section...

  3. 40 CFR 80.75 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... Administrator, with the fourth quarterly report, a report that contains the identity of each covered area that... Administrator; and (2) Signed and certified as correct by the owner or a responsible corporate officer of...

  4. Reducing Wind Tunnel Data Requirements Using Neural Networks

    Science.gov (United States)

    Ross, James C.; Jorgenson, Charles C.; Norgaard, Magnus

    1997-01-01

    The use of neural networks to minimize the amount of data required to completely define the aerodynamic performance of a wind tunnel model is examined. The accuracy requirements for commercial wind tunnel test data are very severe and are difficult to reproduce using neural networks. For the current work, multiple input, single output networks were trained using a Levenberg-Marquardt algorithm for each of the aerodynamic coefficients. When applied to the aerodynamics of a 55% scale model of a U.S. Air Force/ NASA generic fighter configuration, this scheme provided accurate models of the lift, drag, and pitching-moment coefficients. Using only 50% of the data acquired during, the wind tunnel test, the trained neural network had a predictive accuracy equal to or better than the accuracy of the experimental measurements.

  5. [Bedtime administration of metformin may reduce insulin requirements].

    Science.gov (United States)

    Ravina, A; Minuchin, O

    1990-10-01

    The administration of metformin, as glucophage retard, at bedtime instead of supper time may improve diabetes control by reducing morning hyperglycemia. This modification of glucophage treatment was tried in 3 groups of diabetic patients: I. those with secondary failure of routine treatment with sulfonylurea (SU) and glucophage; II. those with combined SU and bedtime insulin; III. Type 1 patients with early morning hypoglycemia. The first 3 months of observation in 258 patients showed that 136 (52.7%) reacted very well to the change. In Group I the addition of insulin to SU could be postponed. In Group II, night insulin could be reduced or eliminated. In Group III, evening or night insulin could be reduced by up to 70%. There was no early morning hypoglycemia nor morning hyperglycemia. The success rate in the 2 Type 2 groups was better (72% and 60%) than in the Type 1 group (34%). 30 patients (11.6%) had to stop the treatment because of side effects of the glucophage (mainly diarrhea or nausea). So far, we have found no clinical signs that might indicate which patients might benefit from this modification of treatment. A fasting blood sugar done within 2-3 days after the change in treatment may immediately indicate whether the new treatment is effective.

  6. 15 CFR 760.5 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... by the reporting entity to edit the public inspection copy of the accompanying document(s) as... intact and another copy must be edited by the reporting entity to delete the same information which it... addition, the reporting entity may delete from this copy information that is considered confidential...

  7. 49 CFR 585.76 - Reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... years as complying with the upgraded moving deformable barrier (S7.2 of Standard No. 214)(49 CFR 571.214... concerning its compliance with the moving deformable barrier requirements of S7 of Standard No. 214 and with... meeting the moving deformable barrier test requirements of S7.2 of Standard No. 214, Side...

  8. 7 CFR 1421.406 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ...-MARKETING ASSISTANCE LOANS AND LOAN DEFICIENCY PAYMENTS FOR 2008 THROUGH 2012 Designated Marketing... financial statement prepared according to generally accepted accounting principles; (2) A report of audit...

  9. Wind increases "evaporative demand" but reduces plant water requirements

    Science.gov (United States)

    Schymanski, S. J.; Or, D.

    2015-12-01

    Transpiration is commonly conceptualised as a fraction of some potential rate, determined by stomatal or canopy resistance. Therefore, so-called "atmospheric evaporative demand" or "potential evaporation" is generally used alongside with precipitation and soil moisture to characterise the environmental conditions that affect plant water use. An increase in potential evaporation (e.g. due to climate change) is generally believed to cause increased transpiration and/or vegetation water stress, aggravating drought effects. In the present study, we investigated the question whether potential evaporation constitutes a meaningful reference for transpiration and compared sensitivity of potential evaporation and leaf transpiration to atmospheric forcing. Based on modelling results and supporting experimental evidence, we conclude that stomatal resistance cannot be parameterised as a factor relating transpiration to potential evaporation, as the ratio between transpiration and potential evaporation not only varies with stomatal resistance, but also with wind speed, air temperature, irradiance and relative humidity. Furthermore, the effect of wind speed in particular implies increase in potential evaporation, which is commonly interpreted as increased "water stress", but at the same time can reduce leaf transpiration, implying a decrease in water demand at the leaf scale. In fact, in a range of field measurements, we found that water use efficiency (WUE, carbon uptake per water transpired) commonly increases with increasing wind speed, enabling plants to conserve water during photosynthesis. We estimate that the observed global decrease in terrestrial near-surface wind speeds could have reduced WUE at a magnitude similar to the increase in WUE attributed to global rise in atmospheric carbon dioxide concentrations. We conclude that trends in wind speed and atmospheric carbon dioxide concentrations have to be considered explicitly for the estimation of drought effects on

  10. 12 CFR 363.2 - Annual reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Annual reporting requirements. 363.2 Section 363.2 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY ANNUAL INDEPENDENT AUDITS AND REPORTING REQUIREMENTS § 363.2 Annual reporting requirements....

  11. 78 FR 31475 - Rescission of Quarterly Financial Reporting Requirements

    Science.gov (United States)

    2013-05-24

    ... financial reporting requirements for certain for-hire motor carriers of property (Form QFR) and for-hire... the financial reporting requirements transferred from the Interstate Commerce Commission (ICC) to... Provision The proposal would eliminate the quarterly financial reporting requirements for certain...

  12. 46 CFR 403.300 - Financial reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Financial reporting requirements. 403.300 Section 403... UNIFORM ACCOUNTING SYSTEM Reporting Requirements § 403.300 Financial reporting requirements. (a) General: (1) The financial statements shall list each active account, including subsidiary accounts. (2)...

  13. 50 CFR 300.34 - Reporting requirements.

    Science.gov (United States)

    2010-10-01

    ..., a report must be submitted to the Administrator by telex, transmission via VMS unit, facsimile, or e... must be submitted to the Administrator by telex, transmission via VMS unit, facsimile, or e-mail that... Administrator must be reported in the format provided by the Regional Administrator and submitted by...

  14. 45 CFR 400.120 - Reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... Public Welfare Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Child Welfare..., the following reports on each unaccompanied minor: (a) An initial report within 30 days of the date of...

  15. 20 CFR 627.455 - Reports required.

    Science.gov (United States)

    2010-04-01

    ... Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR GENERAL PROVISIONS GOVERNING...) Financial reports. (1) Financial reports for programs under titles I, II, and III shall be submitted to DOL... outlays on an accrual basis. If the recipient's accounting records are not normally kept on the...

  16. HEP Science Network Requirements--Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Bakken, Jon; Barczyk, Artur; Blatecky, Alan; Boehnlein, Amber; Carlson, Rich; Chekanov, Sergei; Cotter, Steve; Cottrell, Les; Crawford, Glen; Crawford, Matt; Dart, Eli; Dattoria, Vince; Ernst, Michael; Fisk, Ian; Gardner, Rob; Johnston, Bill; Kent, Steve; Lammel, Stephan; Loken, Stewart; Metzger, Joe; Mount, Richard; Ndousse-Fetter, Thomas; Newman, Harvey; Schopf, Jennifer; Sekine, Yukiko; Stone, Alan; Tierney, Brian; Tull, Craig; Zurawski, Jason

    2010-04-27

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the US Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In August 2009 ESnet and the Office of High Energy Physics (HEP), of the DOE Office of Science, organized a workshop to characterize the networking requirements of the programs funded by HEP. The International HEP community has been a leader in data intensive science from the beginning. HEP data sets have historically been the largest of all scientific data sets, and the communty of interest the most distributed. The HEP community was also the first to embrace Grid technologies. The requirements identified at the workshop are summarized below, and described in more detail in the case studies and the Findings section: (1) There will be more LHC Tier-3 sites than orginally thought, and likely more Tier-2 to Tier-2 traffic than was envisioned. It it not yet known what the impact of this will be on ESnet, but we will need to keep an eye on this traffic. (2) The LHC Tier-1 sites (BNL and FNAL) predict the need for 40-50 Gbps of data movement capacity in 2-5 years, and 100-200 Gbps in 5-10 years for HEP program related traffic. Other key HEP sites include LHC Tier-2 and Tier-3 sites, many of which are located at universities. To support the LHC, ESnet must continue its collaborations with university and international networks. (3) While in all cases the deployed 'raw' network bandwidth must exceed the user requirements in order to meet the data transfer and reliability requirements, network engineering for trans

  17. 40 CFR 59.105 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ...) NATIONAL VOLATILE ORGANIC COMPOUND EMISSION STANDARDS FOR CONSUMER AND COMMERCIAL PRODUCTS National Volatile Organic Compound Emission Standards for Automobile Refinish Coatings § 59.105 Reporting... States that is producing, packaging, or importing automobile refinish coatings or coating...

  18. 7 CFR 4284.12 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... the problems or delays that may affect completion of the project. Objectives for the next reporting... completed tasks include, but are not limited to, feasibility studies, marketing plans, business...

  19. 40 CFR 98.146 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ...). (8) Total number of continuous glass melting furnaces. (9) The number of times in the reporting year... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data reporting requirements. 98.146... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Glass Production § 98.146 Data reporting requirements. In...

  20. Reducing residential cooling requirements through the use of electrochromic windows

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, R.; Rubin, M.; Selkowitz, S.

    1995-05-01

    This paper presents the results of a study investigating the energy performance of electrochromic windows in a prototypical residential building under a variety of state switching control strategies. We used the DOE-2.1E energy simulation program to analyze the annual cooling energy and peak demand as a function of glazing type, size, and electrochromic control strategy. A single-story ranch-style home located in the cooling-dominated locations of Miami, FL and Phoenix, AZ was simulated. Electrochromic control strategies analyzed were based on incident total solar radiation, space cooling load, and outside air temperature. Our results show that an electrochromic material with a high reflectance in the colored state provides the best performance for all control strategies. On the other hand, electrochromic switching using space cooling load provides the best performance for all the electrochromic materials. The performance of the incident total solar radiation control strategy varies as a function of the values of solar radiation which trigger the bleached and colored states of the electrochromic (setpoint range); i.e., required cooling decreases as the setpoint range decreases; also, performance differences among electrochromics increases. The setpoint range of outside air temperature control of electrochromics must relate to the ambient weather conditions prevalent in a particular location. If the setpoint range is too large, electrochromic cooling performance is very poor. Electrochromics compare favorably to conventional low-E clear glazings that have high solar heat gain coefficients that are used with overhangs. However, low-E tinted glazings with low solar heat gain coefficients can outperform certain electrochromics. Overhangs should be considered as a design option for electrochromics whose state properties do not change significantly between bleached and colored states.

  1. 10 CFR 490.807 - Reporting requirement.

    Science.gov (United States)

    2010-01-01

    ... DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Alternative Compliance § 490... fuel reduced by the fleet in the waiver year through alternative compliance. (b) A State or covered... statement certifying: (i) The total number of petroleum gallons and/or alternative fuel gge used by...

  2. 40 CFR 141.90 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... corrosion inhibitor products (e.g., orthophosphate to blended phosphate). Long-term changes can include dose... deemed to have optimized corrosion control under § 141.81(b)(3), a water system subject to reduced... residual inhibitor concentration. Long-term treatment changes would not include chemical dose...

  3. Manpower Requirements Report for FY 1981.

    Science.gov (United States)

    1980-02-01

    A I! outpatient basis, especially for minor surgery such as tonsillectomies , and new technology have contributed to this decline in hospitalization... laser systems, weapons and equipment simulators, and computer assisted training has reduced training costs. Officer training is undergoing a detailed

  4. 38 CFR 36.4303 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... insurance of loans to veterans. (Authority: 38 U.S.C. 3703(c)(1)) (e) Upon the failure of the lender to... by a corporate officer of the lending institution which explains why the loan was reported late. The... holder will remain ultimately responsible for any failure of its servicing agent to comply with the...

  5. 14 CFR 374a.6 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ..., until a negative report is filed showing that no debt for such extension of credit is owed to the... debts incurred by the candidate, whether or not incurred in connection with his campaign, and all debts incurred by persons acting on his behalf in connection with such campaign. The indebtedness...

  6. 10 CFR 490.205 - Reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet... file an annual report for each State fleet on or before the December 31 after the close of the model... of new light duty motor vehicles acquired for the fleet by a State during the model year; (2)...

  7. 40 CFR 61.177 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... also include the opacity data used and the calculations performed to determine the reference opacity... converter operating mode; and (3) A written report each quarter of any changes in the operating conditions of the emission capture system, emission control device, or the building housing the converters...

  8. 30 CFR 77.215-2 - Refuse piles; reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Refuse piles; reporting requirements. 77.215-2... COAL MINES Surface Installations § 77.215-2 Refuse piles; reporting requirements. (a) The proposed location of a new refuse pile shall be reported to and acknowledged in writing by the District...

  9. 40 CFR 98.166 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Hydrogen Production § 98.166 Data reporting requirements. In... emissions, then you must report the relevant information required under § 98.36 for the Tier 4 Calculation... process emissions. (2) Annual quantity of hydrogen produced (metric tons) for each process unit and...

  10. 7 CFR 277.11 - Financial reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Financial reporting requirements. 277.11 Section 277... OF STATE AGENCIES § 277.11 Financial reporting requirements. (a) General. This section prescribes... termination of Federal financial support. Requests from State agencies for extension of reporting due...

  11. 46 CFR 252.23 - Financial and other reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Financial and other reporting requirements. 252.23... SERVICES Operation § 252.23 Financial and other reporting requirements. (a) Voyage report. The operator... total loss covered by a policy of insurance. (d) Financial statements. The operator shall submit,...

  12. 46 CFR 298.42 - Reporting requirements-financial statements.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Reporting requirements-financial statements. 298.42... OBLIGATION GUARANTEES Defaults and Remedies, Reporting Requirements, Applicability of Regulations § 298.42 Reporting requirements—financial statements. (a) In general. The financial statements of the Company...

  13. Thesis Report: Resource Utilization Provisioning in MapReduce

    OpenAIRE

    Barati, Hamidreza; Jaberi, Nasrin

    2012-01-01

    In this thesis report, we have a survey on state-of-the-art methods for modelling resource utilization of MapReduce applications regard to its configuration parameters. After implementation of one of the algorithms in literature, we tried to find that if CPU usage modelling of a MapReduce application can be used to predict CPU usage of another MapReduce application.

  14. 49 CFR 180.417 - Reporting and record retention requirements.

    Science.gov (United States)

    2010-10-01

    ... maintain the reports at a regional or terminal office. (3) The requirement in paragraph (c)(1) of this..., modification, stretching, or rebarrelling; and the most recent inspection and test reports made under...

  15. Accountability and Control: Canada’s First Nations Reporting Requirements

    OpenAIRE

    Ron Baker; Bettina Schneider

    2015-01-01

    This paper explores the accountability relationship between the Government of Canada and First Nations Bands arising from Program Devolution. Reporting requirements associated with this relationship have been characterized in a 2002 Report of the Auditor General of Canada as burdensome and of little use to many of the First Nations communities that are compelled to meet them. This study examines the reporting requirements used in the Auditor General ’s report and drawing on institutional theo...

  16. 40 CFR 98.426 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data reporting requirements. 98.426... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Carbon Dioxide § 98.426 Data reporting... use Equation PP-4 of this subpart, report at the corporate level the annual mass of CO2 in metric...

  17. 40 CFR 63.788 - Recordkeeping and reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... day of the reporting period and whether compliance was continuous or intermittent during the reporting... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Recordkeeping and reporting... Recordkeeping and reporting requirements. (a) Each owner or operator of an affected source shall comply with the...

  18. 76 FR 22648 - Resolution Plans and Credit Exposure Reports Required

    Science.gov (United States)

    2011-04-22

    ... Banking Act and that have at least $50 billion in worldwide assets to prepare resolution plans and credit... credit exposure report requirements of the Dodd-Frank Act with respect to foreign banking organizations... Resolution Plans and Credit Exposure Reports Required AGENCIES: Board of Governors of the Federal...

  19. 13 CFR 108.2040 - Reporting and recordkeeping requirements.

    Science.gov (United States)

    2010-01-01

    .... Policies governing reporting, record retention, and recordkeeping requirements applicable to NMVC Companies may be found in subpart H of this part. NMVC Companies also must comply with all reporting, record retention, and recordkeeping requirements set forth in Circular A-110 of the Office of Management and...

  20. 24 CFR 884.225 - PHA reporting requirements. [Reserved

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false PHA reporting requirements. 884.225 Section 884.225 Housing and Urban Development Regulations Relating to Housing and Urban Development... RURAL RENTAL HOUSING PROJECTS Project Development and Operation § 884.225 PHA reporting requirements....

  1. 24 CFR 200.36 - Financial reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Financial reporting requirements. 200.36 Section 200.36 Housing and Urban Development Regulations Relating to Housing and Urban... Regulations § 200.36 Financial reporting requirements. The mortgagor must comply with the financial...

  2. 36 CFR 64.15 - Financial reporting requirements and reimbursements.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Financial reporting requirements and reimbursements. 64.15 Section 64.15 Parks, Forests, and Public Property NATIONAL PARK SERVICE... RIGHTS-OF-WAY § 64.15 Financial reporting requirements and reimbursements. Payments to applicants...

  3. 77 FR 51705 - Rescission of Quarterly Financial Reporting Requirements

    Science.gov (United States)

    2012-08-27

    ... Financial Reporting Requirements AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION... the quarterly financial reporting requirements for certain for-hire motor carriers of property (Form... notice of proposed rulemaking in the near future proposing the elimination of the quarterly...

  4. 7 CFR 735.101 - Financial records and reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Financial records and reporting requirements. 735.101... Warehouse Licensing § 735.101 Financial records and reporting requirements. (a) Warehouse operators must maintain complete, accurate, and current financial records that must be available to DACO for review...

  5. 48 CFR 26.303 - Data collection and reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Data collection and reporting requirements. 26.303 Section 26.303 Federal Acquisition Regulations System FEDERAL ACQUISITION... and Minority Institutions 26.303 Data collection and reporting requirements. Executive Order...

  6. 77 FR 11623 - Reports, Forms, and Recordkeeping Requirements

    Science.gov (United States)

    2012-02-27

    ... restraints. The standard, which seeks to reduce whiplash injuries in rear collisions, currently requires head... manufactured on or after September 1, 2008. The owner's manual must clearly identify which seats are...

  7. 42 CFR 460.204 - Financial recordkeeping and reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Financial recordkeeping and reporting requirements...-INCLUSIVE CARE FOR THE ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.204 Financial... financial statements. (c) Accepted reporting practices. Except as specified under Medicare principles...

  8. 78 FR 58544 - Agency Recordkeeping/Reporting Requirements Under Emergency

    Science.gov (United States)

    2013-09-24

    ... HUMAN SERVICES Administration for Children and Families Agency Recordkeeping/Reporting Requirements Under Emergency Review by the Office of Management and Budget (OMB) Title: OCSE-75 Tribal Child Support... accomplishments in an annual narrative report and submit the OCSE-75 report annually. Respondents: Tribal...

  9. Accountability and Control: Canada’s First Nations Reporting Requirements

    Directory of Open Access Journals (Sweden)

    Ron Baker

    2015-06-01

    Full Text Available This paper explores the accountability relationship between the Government of Canada and First Nations Bands arising from Program Devolution. Reporting requirements associated with this relationship have been characterized in a 2002 Report of the Auditor General of Canada as burdensome and of little use to many of the First Nations communities that are compelled to meet them. This study examines the reporting requirements used in the Auditor General ’s report and drawing on institutional theory and accountability literature develops a theoretically informed argument positioning Program Devolution, as it was practiced, as a colonizing undertaking that undermines self-government.

  10. 75 FR 76781 - Reports, Forms, and Record Keeping Requirements

    Science.gov (United States)

    2010-12-09

    ..., underage drinking prevention programs, administrative license suspension or revocation for DUI, and self... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration Reports, Forms, and Record Keeping Requirements...

  11. Correlation between laboratory services and reporting requirements for selected zoonoses

    OpenAIRE

    1981-01-01

    Questionnaires on the reporting required and the diagnostic services provided for selected zoonoses were completed by all departments of public health and all departments of agriculture in the 50 States. The public health departments offered services for a larger number of zoonoses than did the agricultural agencies. The correlation between the required reporting of a disease and the availability of services for that disease was stronger in the case of public health laboratories.

  12. Investigational new drug safety reporting requirements for human drug and biological products and safety reporting requirements for bioavailability and bioequivalence studies in humans. Final rule.

    Science.gov (United States)

    2010-09-29

    The Food and Drug Administration (FDA) is amending its regulations governing safety reporting requirements for human drug and biological products subject to an investigational new drug application (IND). The final rule codifies the agency's expectations for timely review, evaluation, and submission of relevant and useful safety information and implements internationally harmonized definitions and reporting standards. The revisions will improve the utility of IND safety reports, reduce the number of reports that do not contribute in a meaningful way to the developing safety profile of the drug, expedite FDA's review of critical safety information, better protect human subjects enrolled in clinical trials, subject bioavailability and bioequivalence studies to safety reporting requirements, promote a consistent approach to safety reporting internationally, and enable the agency to better protect and promote public health.

  13. 25 CFR Appendix B to Part 276 - Financial Reporting Requirements

    Science.gov (United States)

    2010-04-01

    ... require forecasts of Federal cash requirement in the Remarks section of the report. (3) When practical and... advances are monitored through other forms contained in this appendix or the grantee's accounting controls... of Management and Budget Circular No. A-40, as revised....

  14. 31 CFR 128.1 - General reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false General reporting requirements. 128.1 Section 128.1 Money and Finance: Treasury Regulations Relating to Money and Finance REPORTING OF... credit that are, in whole or part, denominated in a foreign currency; and (iii) The creation or...

  15. 32 CFR 203.17 - Technical assistance provider reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Technical assistance provider reporting... OF DEFENSE (CONTINUED) MISCELLANEOUS TECHNICAL ASSISTANCE FOR PUBLIC PARTICIPATION (TAPP) IN DEFENSE ENVIRONMENTAL RESTORATION ACTIVITIES § 203.17 Technical assistance provider reporting requirements. Each...

  16. 19 CFR 210.74 - Modification of reporting requirements.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Modification of reporting requirements. 210.74 Section 210.74 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR... warrants, announce that a modification of reporting is under consideration and ask for comment, but it...

  17. 40 CFR Table 8 to Subpart Uuuu of... - Reporting Requirements

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Reporting Requirements 8 Table 8 to Subpart UUUU of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS....5580(b). 2. if there were no periods during which the CMS was out-of-control, then the report...

  18. 40 CFR 98.366 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Manure Management § 98.366 Data reporting requirements. (a) In...) Typical animal mass (for each animal type). (7) Total facility emissions (results of Equation JJ-15). (8) CH4 emissions from manure management system components listed in § 98.360(b), except...

  19. 40 CFR 98.296 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... capacity of soda ash for each manufacturing line (tons). (5) Monthly consumption of trona or liquid... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Soda Ash Manufacturing § 98.296 Data reporting requirements... specified in paragraphs (a) or (b) of this section, as appropriate for each soda ash manufacturing...

  20. 40 CFR 716.21 - Chemical specific reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Chemical specific reporting requirements. 716.21 Section 716.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.21 Chemical specific...

  1. 78 FR 68705 - Premerger Notification; Reporting and Waiting Period Requirements

    Science.gov (United States)

    2013-11-15

    ... Classification System Industry Group 3254) (``pharmaceutical industry'') is reportable under the Hart Scott... interests must confer control in order to be reportable. \\4\\ As the Second Circuit explained in SCM Corp. v... certain water safety requirements; although EPA had deemed the water distribution system to be safe...

  2. 77 FR 28343 - Insurer Reporting Requirements; List of Insurers Required To File Reports

    Science.gov (United States)

    2012-05-14

    ..., require each agency to write all rules in plain language. Application of the principles of plain language... established this limit to encourage you to write your primary comments concisely. You may attach necessary..., using the Bureau of Labor Statistics Consumer Price Index for 2012 (see http://www.bls.gov/cpi ). The...

  3. 75 FR 34966 - Insurer Reporting Requirements; List of Insurers Required To File Reports

    Science.gov (United States)

    2010-06-21

    ... Executive Order 12866 and the President's memorandum of June 1, 1998, require each agency to write all rules... comments must not exceed 15 pages long (49 CFR 553.21). We established this limit to encourage you to write... adjusted for inflation, using the Bureau of Labor Statistics Consumer Price Index for 2009 (see http://www...

  4. 76 FR 20298 - Insurer Reporting Requirements; List of Insurers; Required To File Reports

    Science.gov (United States)

    2011-04-12

    ... memorandum of June 1, 1998, require each agency to write all rules in plain language. Application of the... (49 CFR 553.21). We established this limit to encourage you to write your primary comments concisely... adjusted for inflation, using the Bureau of Labor Statistics Consumer Price Index for 2011 (see http://www...

  5. 40 CFR 370.20 - What are the reporting requirements of this part?

    Science.gov (United States)

    2010-07-01

    ... reporting requirements of this part consist of MSDS reporting and inventory reporting. If you are the owner... with both types of reporting requirements. MSDS reporting requirements are addressed in §§ 370.30... With MSDS Reporting ...

  6. Steps physicians report taking to reduce diversion of buprenorphine.

    Science.gov (United States)

    Yang, Amy; Arfken, Cynthia L; Johanson, Chris-Ellyn

    2013-01-01

    Physicians are challenged to effectively treat opioid dependent patients while minimizing diversion of potentially abusable medications, such as buprenorphine. The present study was designed to obtain information on steps physicians report taking to reduce diversion of buprenorphine. National quarterly surveys from 2008 to 2009 of qualified physicians who have prescribed buprenorphine were analyzed (N = 2,330). One part of the survey queried physicians about what steps they had taken to reduce abuse and diversion of buprenorphine from a pre-specified list of 12 steps. Other parts of the survey included questions on the physicians' training and experience. Physicians reported taking a mean of 4.4 steps. Longer experience prescribing buprenorphine, more buprenorphine-related educational training, and concern about diversion as a limitation on using buprenorphine for maintenance were associated with higher number of steps taken. Physicians are currently taking multiple steps to reduce diversion. Future research needs to verify if these steps are effective or are instead reducing access to treatment. Copyright © American Academy of Addiction Psychiatry.

  7. MORE: Management of Requirements in NPP Modernisation Projects, final report

    Energy Technology Data Exchange (ETDEWEB)

    Fredriksen, R.; Katta, V.; Raspotnig, C. (Inst. for energiteknikk (IFE) (Norway)); Valkonen, J. (Technical Research Centre of Finland (VTT) (Finland))

    2008-09-15

    This report documents the work and related activities of the MORE (Management of Requirements in NPP Modernisation Projects) (NKS-R project number NKS-R-2005-47) project. This report also provides a summary of the project activities and deliverables, and discusses possible application areas. The project has aimed at the industrial utilisation of the results from the TACO: (Traceability and Communication of Requirements in Digital I and C Systems Development) (NKS-R project number NKS-R-2002-16, completed June, 2005) project, and practical application of improved approaches and methods for requirements engineering and change management. Finally, the report provides a brief description of the extended industrial network and disseminations of the results in Nordic and NKS related events such as seminars and workshops. (author)

  8. FASB's ASU 2011-7 changes financial statement reporting requirements.

    Science.gov (United States)

    Reinstein, Alan; Churyk, Natalie Tatiana

    2012-02-01

    FASB's new Accounting Standards Update 2011-07 will change how healthcare entities accumulate and report major portions of their financial statements, including patient revenues, net accounts receivables, and bad-debt expenses. Healthcare entities now must reclassify their provisions for bad debts associated with patient service revenue from an operating expense to a deduction from patient service revenue (net of contractual allowances and discounts). International Financial Reporting Standards do not require healthcare entities to comply with this new standard.

  9. Automatic Analysis of Critical Incident Reports: Requirements and Use Cases.

    Science.gov (United States)

    Denecke, Kerstin

    2016-01-01

    Increasingly, critical incident reports are used as a means to increase patient safety and quality of care. The entire potential of these sources of experiential knowledge remains often unconsidered since retrieval and analysis is difficult and time-consuming, and the reporting systems often do not provide support for these tasks. The objective of this paper is to identify potential use cases for automatic methods that analyse critical incident reports. In more detail, we will describe how faceted search could offer an intuitive retrieval of critical incident reports and how text mining could support in analysing relations among events. To realise an automated analysis, natural language processing needs to be applied. Therefore, we analyse the language of critical incident reports and derive requirements towards automatic processing methods. We learned that there is a huge potential for an automatic analysis of incident reports, but there are still challenges to be solved.

  10. 47 CFR 54.711 - Contributor reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... administrators of the North American Numbering Plan administration cost recovery (See 47 CFR 52.16 of this chapter), the local number portability cost recovery (See 47 CFR 52.32 of this chapter), and the TRS Fund... (CONTINUED) UNIVERSAL SERVICE Administration § 54.711 Contributor reporting requirements. (a)...

  11. 76 FR 5494 - Pipeline Safety: Mechanical Fitting Failure Reporting Requirements

    Science.gov (United States)

    2011-02-01

    ... Management Program. To comply with the PRA requirements, PHMSA issued a 60-day comment period with comments... eliminated by lubrication, adjustment, or tightening, is not a leak. ``Hazardous Leak'' is defined in Sec... by lubrication, adjustment, or tightening. Part E. EFV Data Operators should simply report all...

  12. 40 CFR 98.66 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... emission factors) and the last date when the smelter-specific-slope coefficients (or overvoltage emission... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data reporting requirements. 98.66 Section 98.66 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR...

  13. 40 CFR 98.86 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ...O in CKD. (10) Monthly kiln-specific clinker CO2 emission factors for each kiln (metric tons CO2/metric ton clinker produced). (11) Quarterly kiln-specific CKD CO2 emission factors for each kiln (metric... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Data reporting requirements....

  14. 40 CFR 141.175 - Reporting and recordkeeping requirements.

    Science.gov (United States)

    2010-07-01

    ... § 141.75(b)(1). (a) Turbidity measurements as required by § 141.173 must be reported within 10 days... includes: (1) The total number of filtered water turbidity measurements taken during the month. (2) The number and percentage of filtered water turbidity measurements taken during the month which are less...

  15. 40 CFR 60.385 - Recordkeeping and reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... Metallic Mineral Processing Plants § 60.385 Recordkeeping and reporting requirements. (a) The owner or... measurements of both the change in pressure of the gas stream across the scrubber and the scrubbing liquid flow... surveillance adopted by such States. In that event, affected sources within the State will be relieved of...

  16. 40 CFR 146.13 - Operating, monitoring and reporting requirements.

    Science.gov (United States)

    2010-07-01

    ...; (iii) Periodic monitoring of the ground water quality in the first aquifer overlying the injection zone; (iv) Periodic monitoring of the ground water quality in the lowermost USDW; and (v) Any additional... Applicable to Class I Wells § 146.13 Operating, monitoring and reporting requirements. (a)...

  17. 12 CFR 1261.12 - Reporting requirements for Bank directors.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Reporting requirements for Bank directors. 1261.12 Section 1261.12 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS FEDERAL HOME LOAN BANK DIRECTORS Federal Home Loan Bank Boards of Directors: Eligibility and Elections §...

  18. 40 CFR 63.850 - Notification, reporting, and recordkeeping requirements.

    Science.gov (United States)

    2010-07-01

    ... as a result of excess emissions. (e) Recordkeeping. The owner or operator shall maintain files of all... operator may retain records on microfilm, on a computer, on computer disks, on magnetic tape, or on microfiche; (3) The owner or operator may report required information on paper or on a labeled computer...

  19. 77 FR 9725 - Reports, Forms, and Recordkeeping Requirements

    Science.gov (United States)

    2012-02-17

    ... insurance companies and rental/leasing companies comply with 49 CFR Part 544, Insurer Reporting Requirement... Anti Car Theft Act (ACTA) of 1992 (Pub. L. 102-519). NHTSA is authorized under 49 U.S.C. 33112, to... insurance companies and rental/leasing companies to provide information to NHTSA on comprehensive...

  20. 40 CFR 464.03 - Monitoring and reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... Monitoring and reporting requirements. (a) As an alternative to monitoring for TTO (total toxic organics), an... Grease standard shall be considered equivalent to complying with the TTO standard. Alternate Oil and Grease standards are provided as substitutes for the TTO standards provided in §§ 464.15, 464.16,...

  1. 21 CFR 814.126 - Postapproval requirements and reports.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Postapproval requirements and reports. 814.126 Section 814.126 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES..., precautions, and adverse reactions in the device's labeling; and (v) A summary of any changes made to...

  2. 38 CFR 3.277 - Eligibility reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... Improved Pension Program Which Became Effective January 1, 1979 § 3.277 Eligibility reporting requirements... of estate; (3) Marital status; (4) Nursing home patient status; (5) School enrollment status of a... circumstances: (i) If the Social Security Administration has not verified the beneficiary's Social...

  3. 13 CFR 108.640 - Requirement to file portfolio financing reports (SBA Form 1031).

    Science.gov (United States)

    2010-01-01

    ... ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Recordkeeping, Reporting, and Examination Requirements for NMVC Companies Reporting Requirements for Nmvc Companies § 108.640 Requirement to...

  4. Reducing cancelled surgery operations in a hospital: brief report

    Directory of Open Access Journals (Sweden)

    Ali Mohammad Mosadeghrad

    2016-08-01

    Full Text Available Background: Operation theatre in a hospital requires considerable human and physical resources to deliver surgery services on an agreed schedule. However, operation theatres are sometimes underutilized due to avoidable last minute cancellations of operations. Cancellation of operations on the day of intended surgery results in operation theatre planning difficulties, hospital inefficiency and resource wastage. In addition, it causes stress for patients and their relatives and results in unnecessary hospital staying. Cancellation of planned operations could be avoided by applying appropriate management strategies and techniques. Quality management as an organizational strategy helps enhance hospital departments’ productivity. Methods: This study aimed to reduce cancelled surgeries in Shahid Rajaei Hospital in Tehran using a quality management model. A participatory action research was used for the intervention between April 2013 and March 2014. Information on operations cancelled on the day of surgery obtained each day from the operating theatre list. Using a checklist, the reasons for operations cancellation were identified, investigated and an action plan was developed for its reduction. The plan was implemented using the action research cycle. Results: The number of surgeries increased by 4.06 percent and operations cancellation was reduced by 32.4 percent using the quality management strategy. Surgeon and anesthetist related factors, over-running of previous surgery, changes in patient clinical status and lack of intensive care unit beds were the main reasons for cancelling surgeries. Standardization of processes, proper planning and using anesthetics clinic helped reduce the operations cancellation. Conclusion: Last minute surgeries cancellation is potentially avoidable. Implementing an appropriate quality management model helps enhance hospital departments’ productivity and reduce surgical cancellation.

  5. TA-55 Final Safety Analysis Report Comparison Document and DOE Safety Evaluation Report Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Alan Bond

    2001-04-01

    This document provides an overview of changes to the currently approved TA-55 Final Safety Analysis Report (FSAR) that are included in the upgraded FSAR. The DOE Safety Evaluation Report (SER) requirements that are incorporated into the upgraded FSAR are briefly discussed to provide the starting point in the FSAR with respect to the SER requirements.

  6. National Land Imaging Requirements (NLIR) Pilot Project summary report: summary of moderate resolution imaging user requirements

    Science.gov (United States)

    Vadnais, Carolyn; Stensaas, Gregory

    2014-01-01

    Under the National Land Imaging Requirements (NLIR) Project, the U.S. Geological Survey (USGS) is developing a functional capability to obtain, characterize, manage, maintain and prioritize all Earth observing (EO) land remote sensing user requirements. The goal is a better understanding of community needs that can be supported with land remote sensing resources, and a means to match needs with appropriate solutions in an effective and efficient way. The NLIR Project is composed of two components. The first component is focused on the development of the Earth Observation Requirements Evaluation System (EORES) to capture, store and analyze user requirements, whereas, the second component is the mechanism and processes to elicit and document the user requirements that will populate the EORES. To develop the second component, the requirements elicitation methodology was exercised and refined through a pilot project conducted from June to September 2013. The pilot project focused specifically on applications and user requirements for moderate resolution imagery (5–120 meter resolution) as the test case for requirements development. The purpose of this summary report is to provide a high-level overview of the requirements elicitation process that was exercised through the pilot project and an early analysis of the moderate resolution imaging user requirements acquired to date to support ongoing USGS sustainable land imaging study needs. The pilot project engaged a limited set of Federal Government users from the operational and research communities and therefore the information captured represents only a subset of all land imaging user requirements. However, based on a comparison of results, trends, and analysis, the pilot captured a strong baseline of typical applications areas and user needs for moderate resolution imagery. Because these results are preliminary and represent only a sample of users and application areas, the information from this report should only

  7. Operations other than war: Requirements for analysis tools research report

    Energy Technology Data Exchange (ETDEWEB)

    Hartley, D.S. III

    1996-12-01

    This report documents the research effort to determine the requirements for new or improved analysis tools to support decisions at the strategic and operational levels for military Operations Other than War (OOTW). The work was performed for the Commander in Chief, U.S. Pacific Command (USCINCPAC). The data collection was based on workshops attended by experts in OOTWs: analysis personnel from each of the Combatant Commands, the Services, the Office of the Secretary of Defense (OSD), the Joint Staff, and other knowledgeable personnel. Further data were gathered from other workshops and conferences and from the literature. The results of this research begin with the creation of a taxonomy of OOTWs: categories of operations, attributes of operations, and tasks requiring analytical support. The tasks are connected to the Joint Staff`s Universal Joint Task List (UJTL). Historical OOTWs are analyzed to produce frequency distributions by category and responsible CINC. The analysis products are synthesized into a list of requirements for analytical tools and definitions of the requirements. The report concludes with a timeline or roadmap for satisfying the requirements.

  8. AN APPROACH TO REDUCE THE STORAGE REQUIREMENT FOR BIOMETRIC DATA IN AADHAR PROJECT

    Directory of Open Access Journals (Sweden)

    T. Sivakumar

    2013-02-01

    Full Text Available AADHAR is an Indian Government Project to provide unique identification to each Citizen of India. The objective of the project is to collect all the personal details and the biometric traits from each individual. Biometric traits such as iris, face and fingerprint are being collected for authentication. All the information will be stored in a centralized data repository. Considering about the storage requirement for the biometric data of the entire population of India, approximately 20,218 TB of storage space will be required. Since 10 fingerprint data are stored, fingerprint details will take most of the space. In this paper, the storage requirement for the biometric data in the AADHAR project is analyzed and a method is proposed to reduce the storage by cropping the original biometric image before storing. This method can reduce the storage space of the biometric data drastically. All the measurements given in this paper are approximate only.

  9. Military Training: DOD Met Annual Reporting Requirements in Its 2016 Sustainable Ranges Report

    Science.gov (United States)

    2016-06-01

    infrastructure and renewable energy impacts, (6) anticipate climate change impacts,15 and (7) sustain excellence in environmental stewardship. Using...to which DOD’s 2016 Sustainable Ranges Report met statutory reporting requirements. To conduct this work, GAO reviewed DOD’s 2016 report and...GAO’s report after reviewing the draft. What GAO Found The Department of Defense’s (DOD) 2016 Sustainable Ranges Report met the annual statutory

  10. Moly99 Production Facility: Report on Beamline Components, Requirements, Costs

    Energy Technology Data Exchange (ETDEWEB)

    Bishofberger, Kip A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-12-23

    In FY14 we completed the design of the beam line for the linear accelerator production design concept. This design included a set of three bending magnets, quadrupole focusing magnets, and octopoles to flatten the beam on target. This design was generic and applicable to multiple different accelerators if necessary. In FY15 we built on that work to create specifications for the individual beam optic elements, including power supply requirements. This report captures the specification of beam line components with initial cost estimates for the NorthStar production facility.This report is organized as follows: The motivation of the beamline design is introduced briefly, along with renderings of the design. After that, a specific list is provided, which accounts for each beamline component, including part numbers and costs, to construct the beamline. After that, this report details the important sections of the beamline and individual components. A final summary and list of follow-on activities completes this report.

  11. Reduced cancer risk in vegetarians: an analysis of recent reports.

    Science.gov (United States)

    Lanou, Amy Joy; Svenson, Barbara

    2010-12-20

    This report reviews current evidence regarding the relationship between vegetarian eating patterns and cancer risk. Although plant-based diets including vegetarian and vegan diets are generally considered to be cancer protective, very few studies have directly addressed this question. Most large prospective observational studies show that vegetarian diets are at least modestly cancer protective (10%-12% reduction in overall cancer risk) although results for specific cancers are less clear. No long-term randomized clinical trials have been conducted to address this relationship. However, a broad body of evidence links specific plant foods such as fruits and vegetables, plant constituents such as fiber, antioxidants and other phytochemicals, and achieving and maintaining a healthy weight to reduced risk of cancer diagnosis and recurrence. Also, research links the consumption of meat, especially red and processed meats, to increased risk of several types of cancer. Vegetarian and vegan diets increase beneficial plant foods and plant constituents, eliminate the intake of red and processed meat, and aid in achieving and maintaining a healthy weight. The direct and indirect evidence taken together suggests that vegetarian diets are a useful strategy for reducing risk of cancer.

  12. Reduced cancer risk in vegetarians: an analysis of recent reports

    Directory of Open Access Journals (Sweden)

    Amy Joy Lanou

    2010-12-01

    Full Text Available Amy Joy Lanou1, Barbara Svenson21Department of Health and Wellness, 2Ramsey Library, University of North Carolina Asheville, Asheville, NC, USAAbstract: This report reviews current evidence regarding the relationship between vegetarian eating patterns and cancer risk. Although plant-based diets including vegetarian and vegan diets are generally considered to be cancer protective, very few studies have directly addressed this question. Most large prospective observational studies show that vegetarian diets are at least modestly cancer protective (10%–12% reduction in overall cancer risk although results for specific cancers are less clear. No long-term randomized clinical trials have been conducted to address this relationship. However, a broad body of evidence links specific plant foods such as fruits and vegetables, plant constituents such as fiber, antioxidants and other phytochemicals, and achieving and maintaining a healthy weight to reduced risk of cancer diagnosis and recurrence. Also, research links the consumption of meat, especially red and processed meats, to increased risk of several types of cancer. Vegetarian and vegan diets increase beneficial plant foods and plant constituents, eliminate the intake of red and processed meat, and aid in achieving and maintaining a healthy weight. The direct and indirect evidence taken together suggests that vegetarian diets are a useful strategy for reducing risk of cancer.Keywords: diet, vegan, prevention

  13. Reduced cancer risk in vegetarians: an analysis of recent reports

    Science.gov (United States)

    Lanou, Amy Joy; Svenson, Barbara

    2011-01-01

    This report reviews current evidence regarding the relationship between vegetarian eating patterns and cancer risk. Although plant-based diets including vegetarian and vegan diets are generally considered to be cancer protective, very few studies have directly addressed this question. Most large prospective observational studies show that vegetarian diets are at least modestly cancer protective (10%–12% reduction in overall cancer risk) although results for specific cancers are less clear. No long-term randomized clinical trials have been conducted to address this relationship. However, a broad body of evidence links specific plant foods such as fruits and vegetables, plant constituents such as fiber, antioxidants and other phytochemicals, and achieving and maintaining a healthy weight to reduced risk of cancer diagnosis and recurrence. Also, research links the consumption of meat, especially red and processed meats, to increased risk of several types of cancer. Vegetarian and vegan diets increase beneficial plant foods and plant constituents, eliminate the intake of red and processed meat, and aid in achieving and maintaining a healthy weight. The direct and indirect evidence taken together suggests that vegetarian diets are a useful strategy for reducing risk of cancer. PMID:21407994

  14. Advanced Scientific Computing Research Network Requirements: ASCR Network Requirements Review Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Bacon, Charles [Argonne National Lab. (ANL), Argonne, IL (United States); Bell, Greg [ESnet, Berkeley, CA (United States); Canon, Shane [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dart, Eli [ESnet, Berkeley, CA (United States); Dattoria, Vince [Dept. of Energy (DOE), Washington DC (United States). Office of Science. Advanced Scientific Computing Research (ASCR); Goodwin, Dave [Dept. of Energy (DOE), Washington DC (United States). Office of Science. Advanced Scientific Computing Research (ASCR); Lee, Jason [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hicks, Susan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Holohan, Ed [Argonne National Lab. (ANL), Argonne, IL (United States); Klasky, Scott [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lauzon, Carolyn [Dept. of Energy (DOE), Washington DC (United States). Office of Science. Advanced Scientific Computing Research (ASCR); Rogers, Jim [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Shipman, Galen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Skinner, David [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Tierney, Brian [ESnet, Berkeley, CA (United States)

    2013-03-08

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the U.S. Department of Energy (DOE) Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. In support of SC programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 25 years. In October 2012, ESnet and the Office of Advanced Scientific Computing Research (ASCR) of the DOE SC organized a review to characterize the networking requirements of the programs funded by the ASCR program office. The requirements identified at the review are summarized in the Findings section, and are described in more detail in the body of the report.

  15. Study of the reduced magnetic field required for thermally assisted magnetization reversal

    Science.gov (United States)

    Firdausi, H. F. Y.; Utari; Purnama, B.

    2016-11-01

    The reduced magnetic field required for thermally magnetization reversal discussed in this paper. Study of thermally assisted magnetization reversal conduct by using micromagnetic simulation. The magnetic dot size of the simulation was 50 nm × 50 nm × 20 nm. The perpendicularly anisotropy constant was 2 × 106 erg/cm3. Initial condition was set single domain configuration. Then a sufficiently thermal pulse was used to get stochastic effect so that the magnetization along to the induce field direction for pico second duration. The results show that the reduced magnetic field mechanism seem to be temporary antiferromagnetic configuration before single domain configuration in alinging along to field direction. The same mechanims observed for modify of thickness dot particles. The require magnetic field of 145 Oe in thermally assisted magnetization reversal open a posibility for MRAM application.

  16. Tracheotomy does not affect reducing sedation requirements of patients in intensive care – a retrospective study

    OpenAIRE

    Veelo, Denise P; Dongelmans, Dave A; Binnekade, Jan M; Korevaar, Johanna C; Vroom, Margreeth B; Schultz, Marcus J

    2006-01-01

    Introduction Translaryngeal intubated and ventilated patients often need sedation to treat anxiety, agitation and/or pain. Current opinion is that tracheotomy reduces sedation requirements. We determined sedation needs before and after tracheotomy of intubated and mechanically ventilated patients. Methods We performed a retrospective analysis of the use of morphine, midazolam and propofol in patients before and after tracheotomy. Results Of 1,788 patients admitted to our intensive care unit d...

  17. Do Laws Requiring Parental Involvement to Obtain an Abortion Help Reduce STIs Among Minors?

    OpenAIRE

    Silvie Colman; Ted Joyce; Thomas Dee

    2011-01-01

    This issue brief evaluates whether policies requiring parental involvement in minors' decision to obtain an abortion can alter their sexual behavior and help reduce the rates of sexually transmitted infections (STIs) among teens. Using data from the STI surveillance system of the Centers for Disease Control and Prevention on cases of gonorrhea and chlamydia, the findings offer little evidence of a link between parental involvement laws and teen STI rates.

  18. Intra-articular mepivacaine reduces interventional analgesia requirements during arthroscopic surgery in dogs.

    Science.gov (United States)

    Dutton, T A G; Gurney, M A; Bright, S R

    2014-08-01

    To document efficacy of intra-articular mepivacaine in dogs based on the hypothesis that this would blunt the haemodynamic response to a nociceptive stimulus (arthroscopic surgery), reducing interventional analgesia requirements. A dose of mepivacaine 2% 0 · 1 ml/kg (2 mg/kg) was injected intra-articularly into one randomly assigned elbow joint before surgery in eight dogs undergoing bilateral elbow arthroscopy. Baseline haemodynamic measurements were recorded immediately before the start of each arthroscopic procedure and repeated at arthrocentesis, saline distension of the joint, incision, arthroscopic cannula and obturator insertion and placement of the second portal and haemodynamic variability calculated. If baseline parameters increased by more than 20% suggesting nociception, 1 µg/kg fentanyl was administered intravenously. Significantly less fentanyl was required during arthroscopy on the mepivacaine treated elbows compared to the non-treated elbows (P = 0 · 003) and the time to first fentanyl administration was significantly longer (P = 0 · 0001) in the mepivacaine treated elbows (21 · 2 ± 4 · 9 minutes) compared to the non-treated elbows (6 · 1 ± 2 · 3 minutes). Haemodynamic variability was significantly reduced in the mepivacaine group (heart rate P = 0 · 04, mean arterial pressure P = 0 · 003). Intra-articular mepivacaine blunts the haemodynamic response to arthroscopic surgery in dogs and reduces interventional analgesia requirement. © 2014 British Small Animal Veterinary Association.

  19. Improvements to parallel plate flow chambers to reduce reagent and cellular requirements

    Directory of Open Access Journals (Sweden)

    Larson Richard S

    2001-09-01

    Full Text Available Abstract Background The parallel plate flow chamber has become a mainstay for examination of leukocytes under physiologic flow conditions. Several design modifications have occurred over the years, yet a comparison of these different designs has not been performed. In addition, the reagent requirements of many designs prohibit the study of rare leukocyte populations and require large amounts of reagents. Results In this study, we evaluate modifications to a newer parallel plate flow chamber design in comparison to the original parallel plate flow chamber described by Lawrence et al. We show that modifications in the chamber size, internal tubing diameters, injection valves, and a recirculation design may dramatically reduce the cellular and reagent requirements without altering measurements. Conclusions These modifications are simple and easily implemented so that study of rare leukocyte subsets using scarce or expensive reagents can occur.

  20. Requirements for significant problem reporting and trend analysis

    Science.gov (United States)

    1988-01-01

    This handbook supplements policies, requirements, and procedures of NMI 8070.3 to ensure that NASA management at each organizational level is: fully aware of trends affecting both the level of safety and the potential for mission success established for both NASA manned space programs and its supporting institutions; fully and independently informed of problems that represent significant risk to the safety of all personnel (including the general populace) and to the success of a mission or operation through a program mechanism herein defined as Significant Problem Reporting; and in full agreement with the level of elimination of these problems through the closed-loop accounting of corrective actions. The requirements of this handbook are supportive of the agency's safety, reliability, maintainability, and quality assurance (SRM&QA) program objectives and are applicable to all organizational elements of NASA connected with or supporting developmental or operational manned space program/projects (including associated payloads) and the related institutional facilities.

  1. Psychological strategies to reduce energy consumption: project summary report

    Energy Technology Data Exchange (ETDEWEB)

    Becker, L J; Seligman, C; Darley, J M

    1979-06-30

    This report reviews the research conducted in connection with a project to apply psychological theory and procedures to the problems of encouraging residential energy conservation. A major part of the project involved surveys of residents' energy-related attitudes. The best (and only consistent) attitudinal predictor of residents' actual energy consumption was their attitude about thermal comfort. A number of other attitudes that could conceivably have been related to consumption, such as attitudes about the reality of the crisis, were not found to be related to consumption. Another major focus of the project was on the effectiveness of feedback (that is, giving residents information about their energy use) as an aid to residents' conservation efforts. A series of experiments demonstrated that frequent, credible energy-consumption feedback, coupled with encouragement to adopt a reasonable but difficult energy-conservation goal, could facilitate conservation. However, these studies also demonstrated that residents could not be given just any kind of information about their energy use as feedback and that even proper feedback would not lead to conservation in all households. Conditions that are crucial for the success of feedback as a conservation aid are discussed. Other studies conducted by the project looked at the effect on energy consumption of (1) a device to reduce air-conditioning waste by signalling when it is cool outside, (2) an automatic multi-setback thermostat, and (3) utility companies' average payment plans. A survey of residents' knowledge of their energy use also was conducted. 23 references.

  2. Krait bite requiring high dose antivenom: a case report.

    Science.gov (United States)

    Sharma, Sanjib Kumar; Koirala, Shekhar; Dahal, Gaheraj

    2002-03-01

    Anti snake venom (ASV) is the most specific therapy available for treatment of snakebite envenomation. The ASV available in Nepal are polyvalent ASV produced in India and are effective against envenomation by cobra and krait, the two most common species found in Eastern Nepal. Neurotoxic signs respond slowly and unconvincingly and continuous absorption of venom may cause recurrent neurotoxicity. Therefore, close observation and continuous administration of ASV is essential to save the victim. We report a case of neurotoxic envenomation due to bite by common krait (Bangarus caeruleus). The victim required very high dose of polyvalent ASV for reversal of neurological manifestations.

  3. Environmental management requirements/defensible costs project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    Lockheed Idaho Technologies Company (LITCO) used a systems engineering approach to develop the first formal requirements baseline for Idaho National Engineering Laboratory (INEL) Environmental Management (EM) Programs. The recently signed Settlement Agreement with the State of Idaho (Batt Agreement), along with dramatically reduced EM funding targets from Department of Energy (DOE) headquarters, drove the immediacy of this effort. Programs have linked top-level requirements to work scope to cost estimates. All EM work, grouped by decision units, was scrubbed by INEL EM programs and by an independent {open_quotes}Murder Board.{close_quotes} Direct participation of upper level management from LITCO and the DOE-Idaho Operations Office ensured best information and decisions. The result is a scrubbed down, defensible budget tied to top-level requirements for use in the upcoming DOE-Headquarters` budget workout, the Internal Review Board, the FY98 Activity Data Sheets submittal, and preparation of the FY97 control accounts and out-year plans. In addition to the remarkable accomplishments during the past eight weeks, major issues were identified and documented and follow-on tasks are underway which will lead to further improvements in INEL EM program management.

  4. Bristles reduce force required to fling wings apart in small insects

    Science.gov (United States)

    Jones, Shannon; Yun, Young; Hedrick, Tyson; Griffith, Boyce; Miller, Laura

    2016-11-01

    The smallest flying insects commonly possess wings with long bristles. Little quantitative information is available on the morphology of these bristles, and the functional importance of these bristles remains a mystery. In this study, we used the immersed boundary method to determine via numerical simulation if bristled wings reduced the force required to fling the wings apart during "clap and fling". The challenge of studying the fluid dynamics of bristles was in resolving the fluid flow between the bristles. The effects of Reynolds number, angle of attack, bristle spacing, and wing-wing interactions were investigated. We found that a bristled wing experiences less force than a solid wing, however bristled wings may act more like solid wings at lower angles of attack than they do at higher angles of attack. In wing-wing interactions, bristled wings significantly decrease the drag required to fling two wings apart compared with solid wings, especially at lower Reynolds numbers. These results support the idea that bristles may offer an aerodynamic benefit during clap and fling by reducing the force required to fling the wings apart in tiny insects.

  5. Rest intervals reduce the number of loading bouts required to enhance bone formation.

    Science.gov (United States)

    Srinivasan, Sundar; Ausk, Brandon J; Bain, Steven D; Gardiner, Edith M; Kwon, Ronald Y; Gross, Ted S

    2015-05-01

    As our society becomes increasingly sedentary, compliance with exercise regimens that require numerous high-energy activities each week become less likely. Alternatively, given an osteogenic exercise intervention that required minimal effort, it is reasonable to presume that participation would be enhanced. Insertion of brief rest intervals between each cycle of mechanical loading holds potential to achieve this result because substantial osteoblast function is activated by many fewer loading repetitions within each loading bout. Here, we examined the complementary hypothesis that the number of bouts per week of rest-inserted loading could be reduced from three bouts per week without loss of osteogenic efficacy. We conducted a series of 3-wk in vivo experiments that noninvasively exposed the right tibiae of mice to either cyclic (1 Hz) or rest-inserted loading interventions and quantified osteoblast function via dynamic histomorphometry. Although reducing loading bouts from three bouts per week (i.e., nine total bouts) to one bout per week (i.e., three total bouts) effectively mitigated the osteogenic benefit of cyclic loading, the same reduction did not significantly reduce periosteal bone formation parameters induced by rest-inserted loading. The osteogenic response was robust to the timing of the rest-inserted loading bouts (three bouts in the first week vs one bout per week for 3 wk). However, elimination of any single bout of the three one-bout-per-week bouts mitigated the osteogenic response to rest-inserted loading. Finally, periosteal osteoblast function assessed after the 3-wk intervention was not sensitive to the timing or number of rest-inserted loading bouts. We conclude that rest-inserted loading holds potential to retain the osteogenic benefits of mechanical loading with significantly reduced frequency of bouts of activity while also enabling greater flexibility in the timing of the activity.

  6. Casing of preinsulated district heating pipes. Functional Requirements. Scientific report

    Energy Technology Data Exchange (ETDEWEB)

    Bryder, K.L.; Feld, T.; Randloev, P.; Vestergaard, J.B.; Noergaard Pedersen, H.; Palle, S.; Amby, L.

    1996-10-01

    Requirements for the wall thickness of the casing pipes in Europe were formulated to clarify the laying conditions, representative for the European district heating areas. We achieved a broad estimate by defining four scenarios for the laying of district heating pipes. It is common to the four scenarios that that all bends, branches etc. are always laid in sand. The four scenarios are differentiated by soil types. The soil types include: Uniform sand, Well graded gravel, Sand with fines and Sand with crushed stone. In the following analysis it was possible to examine the influence from following parameters: Casing thickness; Diameter of steel pipe; Diameter of casing; Material properties (PUR and PE); Soil type. The results from the model showed that uniform sand is the absolute best soil type. Based on the results from and earlier project a laboratory method has been developed. The result was a test method based on the indentation of three mandrels with a diameter of {phi}30 mm with a taper with an angle of 45 deg. and with roundings on the apex of R5 mm, R10 mm and R15 mm, respectively. The mandrels simulate stones. The examinations among other things showed that even a 1.5 mm casing demands an indentation of 20 mm with a R5 mm mandrel before it is perforated. The demanded force is 1.6 kN, which is considerably higher than the theoretically highest force in an actual situation. On this background it is recommended that the minimum requirement for the wall thickness of the casings with diameters less than 200 mm should still follow the EN 253, whereas the minimum requirement for the larger casing pipes securely can be reduced. Based on the tests and an evaluation of the safety factors it is proposed that the wall thickness for the largest pipes can be reduced 50%. Thus the wall thickness of an 800 mm casing should be 6.6 mm with a linear reduction down to 3 mm for 180 mm casing. (EG)

  7. Organisational reviews - requirements, methods and experience. Progress report 2006

    Energy Technology Data Exchange (ETDEWEB)

    Reiman, T.; Oedewald, P.; Wahlstroem, B. [VTT, Technical Research Centre of Finland (Finland); Rollenhagen, C.; Kahlbom, U. [Maelardalen University (FI)

    2007-04-15

    Organisational reviews are important instruments in the continuous quest for improved performance. In the nuclear field there has been an increasing regulatory interest in organisational performance, because incidents and accidents often point to organisational deficiencies as one of the major precursors. Many methods for organisational reviews have been proposed, but they are mostly based on ad hoc approaches to specific problems. The absence of well-established techniques for organisational reviews has already shown to cause discussions and controversies on different levels. The aim of the OrRe project is to collect the experiences from organisational reviews carried out so far and to reflect them in a theoretical model of organisational performance. Furthermore, the project aims to reflect on the criteria for the definition of the scope and content of organisational reviews. Finally, recommendations will be made for guidance for people participating in organisational reviews. This progress report describes regulatory practices in Finland and Sweden together with some case examples of organizational reviews and assessment in both countries. Some issues of concern are raised and an outline for the next year's work is proposed. Issues of concern include the sufficient depth of the assessment, the required competence in assessments, data and criteria problems, definition of the boundaries of the system to be assessed, and the necessary internal support and organisational maturity required for successful assessments. Finally, plans for next year's work are outlined. (au)

  8. TECHNOLOGY REQUIREMENTS FOR IN SITU DECOMMISSIONING WORKSHOP REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Jannik, T.; Lee, P.; Gladden, J.; Langton, C.; Serrato, M.; Urland, C.; Reynolds, E.

    2009-06-30

    In recognition of the increasing attention being focused on In Situ Decommissioning (ISD or entombment) as an acceptable and beneficial decommissioning end state, the Department of Energy's (DOE) Office of Environmental Management (EM) is developing guidance for the implementation of ISD of excess facilities within the DOE complex. Consistent with the overarching DOE goals for increased personnel and environmental safety, reduced technical uncertainties and risks, and overall gains in efficiencies and effectiveness, EM's Office of Deactivation and Decommissioning and Facility Engineering (EM-23) initiated efforts to identify the technical barriers and technology development needs for the optimal implementation of ISD. Savannah River National Laboratory (SRNL), as the EM Corporate Laboratory, conducted an ISD Technology Needs Workshop to identify the technology needs at DOE sites. The overall goal of the workshop was to gain a full understanding of the specific ISD technical challenges, the technologies available, and those needing development. The ISD Workshop was held December 9-10, 2008 in Aiken, SC. Experienced decommissioning operations personnel from Richland Operations Office (RL), Idaho National Laboratory (INL) and Savannah River Site (SRS) along with scientists and engineers specific expertise were assembled to identify incremental and 'game changing' solutions to ISD technology challenges. The workshop and follow-up activities yielded 14 technology needs statements and the recommendation that EM-23 prioritize and pursue the following specific technology development and deployment actions. For each action, the recommended technology acquisition mechanisms (competitive solicitation (CS) or direct funding (TCR)) are provided. Activities that are time critical for ISD projects, or require unique capabilities that reside in the DOE Laboratory system will be funded directly to those institutions. Activities that have longer lead times and

  9. 78 FR 54252 - Information Collection; American Recovery and Reinvestment Act-Reporting Requirements-One Time...

    Science.gov (United States)

    2013-09-03

    ... comments identified by Information Collection 9000- 0166, American Recovery and Reinvestment Act--Reporting... GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION Information Collection; American Recovery and Reinvestment Act-- Reporting Requirements--One Time Reporting Requirements for...

  10. 78 FR 66674 - Revisions to Reporting and Recordkeeping Requirements, and Proposed Confidentiality...

    Science.gov (United States)

    2013-11-06

    ... Confidentiality Determinations Under the Greenhouse Gas Reporting Program AGENCY: Environmental Protection Agency... Recordkeeping Requirements, and Proposed Confidentiality Determinations under the Greenhouse Gas Reporting... Requirements, and Proposed Confidentiality Determinations under the Greenhouse Gas Reporting Program,'' which...

  11. Tracheotomy does not affect reducing sedation requirements of patients in intensive care – a retrospective study

    Science.gov (United States)

    Veelo, Denise P; Dongelmans, Dave A; Binnekade, Jan M; Korevaar, Johanna C; Vroom, Margreeth B; Schultz, Marcus J

    2006-01-01

    Introduction Translaryngeal intubated and ventilated patients often need sedation to treat anxiety, agitation and/or pain. Current opinion is that tracheotomy reduces sedation requirements. We determined sedation needs before and after tracheotomy of intubated and mechanically ventilated patients. Methods We performed a retrospective analysis of the use of morphine, midazolam and propofol in patients before and after tracheotomy. Results Of 1,788 patients admitted to our intensive care unit during the study period, 129 (7%) were tracheotomized. After the exclusion of patients who received a tracheotomy before or at the day of admittance, 117 patients were left for analysis. The daily dose (DD; the amount of sedatives for each day) divided by the mean daily dose (MDD; the mean amount of sedatives per day for the study period) in the week before and the week after tracheotomy was 1.07 ± 0.93 DD/MDD versus 0.30 ± 0.65 for morphine, 0.84 ± 1.03 versus 0.11 ± 0.46 for midazolam, and 0.62 ± 1.05 versus 0.15 ± 0.45 for propofol (p < 0.01). However, when we focused on a shorter time interval (two days before and after tracheotomy), there were no differences in prescribed doses of morphine and midazolam. Studying the course in DD/MDD from seven days before the placement of tracheotomy, we found a significant decline in dosage. From day -7 to day -1, morphine dosage (DD/MDD) declined by 3.34 (95% confidence interval -1.61 to -6.24), midazolam dosage by 2.95 (-1.49 to -5.29) and propofol dosage by 1.05 (-0.41 to -2.01). After tracheotomy, no further decrease in DD/MDD was observed and the dosage remained stable for all sedatives. Patients in the non-surgical and acute surgical groups received higher dosages of midazolam than patients in the elective surgical group. Time until tracheotomy did not influence sedation requirements. In addition, there was no significant difference in sedation between different patient groups. Conclusion In our intensive care unit, sedation

  12. Intravenous lidocaine infusion reduces bispectral index-guided requirements of propofol only during surgical stimulation(dagger)

    NARCIS (Netherlands)

    Hans, G. A.; Lauwick, S. M.; Kaba, A.; Bonhomme, V.; Struys, M. M. R. F.; Hans, P. C.; Lamy, M. L.; Joris, J. L.

    2010-01-01

    I.V. lidocaine reduces volatile anaesthetics requirements during surgery. We hypothesized that lidocaine would also reduce propofol requirements during i.v. anaesthesia. A randomized controlled study of 40 patients tested the effect of i.v. lidocaine (1.5 mg kg(-1) then 2 mg kg(-1) h(-1)) on propofo

  13. [Application of perineum heat therapy during partum to reduce injuries that require post-partum stitches].

    Science.gov (United States)

    Terré-Rull, Carmen; Beneit-Montesinos, Juan Vicente; Gol-Gómez, Roser; Garriga-Comas, Neus; Ferrer-Comalat, Alicia; Salgado-Poveda, Isabel

    2014-01-01

    Evaluate the effectiveness of heat, moist or dry to the perineum during delivery in order to reduce injuries requiring perineal suturing after birth, and to assess its safety in relation to the adaptation of the newborn to extrauterine life. An open multicentre clinical trial directed from the School of Nursing at the University of Barcelona was carried out between 2009 and 2010 in 5 Catalan Hospitals. The sample consisted of 198 pregnant women subjected to the natural protocol for normal delivery assistance. The pregnant women were randomized to three study groups: moist heat (MHG), dry heat (DHG), and control (CG). Usual care of the perineum was performed during labour in all groups and MHG or GCS was also applied in the perineum in the intervention groups. The Apgar score in the newborn and perineum postpartum was then assessed. Statistical tests were performed using a 95% confidence interval. Statistical analyses were performed using the SPSS version 17. Perinea that required no suturing: MHG 71% (47) versus CG 56% (37), OR: 1.803; (95% CI: 0.881-3.687); DHG 62% (41) versus CG 56% (37), OR:1.285 (95% CI: 0.641-2.577); MHG 71% (47) versus DHG 62% (41), OR:1.402 (95% CI: 0.680-2.890). MEAN: Apgar score 5', MHG: 9.91; DHG: 9.98, CG: 9.98. p=0.431. The application of heat therapy to the perineum during labour did not significantly reduce perineal suturing after birth. However, better perineal results were observed with moist heat. Heat therapy does not alter neonatal outcomes measured by Apgar score. Copyright © 2013 Elsevier España, S.L. All rights reserved.

  14. Chitosan Oligosaccharide Reduces Propofol Requirements and Propofol-Related Side Effects.

    Science.gov (United States)

    Li, Zhiwen; Yang, Xige; Song, Xuesong; Ma, Haichun; Zhang, Ping

    2016-12-21

    Propofol is one of the main sedatives but its negative side effects limit its clinical application. Chitosan oligosaccharide (COS), a kind of natural product with anti-pain and anti-inflammatory activities, may be a potential adjuvant to propofol use. A total of 94 patients receiving surgeries were evenly and randomly assigned to two groups: 10 mg/kg COS oral administration and/or placebo oral administration before being injected with propofol. The target-controlled infusion of propofol was adjusted to maintain the values of the bispectral index at 50. All patients' pain was evaluated on a four-point scale and side effects were investigated. To explore the molecular mechanism for the functions of COS in propofol use, a mouse pain model was established. The activities of Nav1.7 were analyzed in dorsal root ganglia (DRG) cells. The results showed that the patients receiving COS pretreatment were likely to require less propofol than the patients pretreated with placebo for maintaining an anesthetic situation (p propofol-pretreated group. The side effects were also more reduced in a COS-treated group than in a placebo-pretreated group. COS reduced the activity of Nav1.7 and its inhibitory function was lost when Nav1.7 was silenced (p > 0.05). COS improved propofol performance by affecting Nav1.7 activity. Thus, COS is a potential adjuvant to propofol use in surgical anesthesia.

  15. Lactobacilli require physical contact to reduce staphylococcal TSST-1 secretion and vaginal epithelial inflammatory response.

    Science.gov (United States)

    Younes, Jessica A; Reid, Gregor; van der Mei, Henny C; Busscher, Henk J

    2016-06-01

    ITALIC! Staphylococcus aureusbiofilms can be found on vaginal epithelia, secreting toxins and causing inflammation. The co-vaginal species ITALIC! Lactobacilluscan alter staphylococcal-induced epithelial secretion of inflammatory cytokines and quench staphylococcal toxic shock syndrome toxin-1 secretion. It is hypothesized that these effects of lactobacilli require direct physical contact between lactobacilli, staphylococci and the epithelium. Indeed, lactobacilli only reduced ITALIC! S. aureus-induced inflammatory cytokine expression when allowed physical contact with vaginal epithelial cells. Furthermore, a reduction in toxic shock syndrome toxin-1 secretion only occurred when a probiotic ITALIC! Lactobacillusstrain was allowed contact, but not when being physically separated from ITALIC! S. aureus Bacterial-probe atomic force microscopy demonstrated that lactobacilli and staphylococci strongly adhere to epithelial cells, while lactobacilli adhere stronger to staphylococci than staphylococci to each other, giving lactobacilli opportunity to penetrate and reside in staphylococcal biofilms, as visualized using confocal laser scanning microscopy with fluorescence ITALIC! in situhybridization probes. These results identify that physical contact and biochemical signaling by lactobacilli are intrinsically linked mechanisms that reduce virulence of ITALIC! S. aureusbiofilm.

  16. 78 FR 76241 - Rescission of Quarterly Financial Reporting Requirements

    Science.gov (United States)

    2013-12-17

    ... passengers to file annual financial reports. Annual financial reports are filed on Form M (for-hire property... continued to collect carriers' annual reports and to furnish copies of the reports requested under the... interested in buying motor carriers. It stated that the quarterly report filings provide useful insight...

  17. An assessment of monitoring requirements and costs of 'Reduced Emissions from Deforestation and Degradation'

    Directory of Open Access Journals (Sweden)

    McCallum Ian

    2009-08-01

    Full Text Available Abstract Background Negotiations on a future climate policy framework addressing Reduced Emissions from Deforestation and Degradation (REDD are ongoing. Regardless of how such a framework will be designed, many technical solutions of estimating forest cover and forest carbon stock change exist to support policy in monitoring and accounting. These technologies typically combine remotely sensed data with ground-based inventories. In this article we assess the costs of monitoring REDD based on available technologies and requirements associated with key elements of REDD policy. Results We find that the design of a REDD policy framework (and specifically its rules can have a significant impact on monitoring costs. Costs may vary from 0.5 to 550 US$ per square kilometre depending on the required precision of carbon stock and area change detection. Moreover, they follow economies of scale, i.e. single country or project solutions will face relatively higher monitoring costs. Conclusion Although monitoring costs are relatively small compared to other cost items within a REDD system, they should be shared not only among countries but also among sectors, because an integrated monitoring system would have multiple benefits for non-REDD management. Overcoming initialization costs and unequal access to monitoring technologies is crucial for implementation of an integrated monitoring system, and demands for international cooperation.

  18. Fossil fuel derivatives with reduced carbon. Phase I final report

    Energy Technology Data Exchange (ETDEWEB)

    Kennel, E.B.; Zondlo, J.W.; Cessna, T.J.

    1999-06-30

    This project involves the simultaneous production of clean fossil fuel derivatives with reduced carbon and sulfur, along with value-added carbon nanofibers. This can be accomplished because the nanofiber production process removes carbon via a catalyzed pyrolysis reaction, which also has the effect of removing 99.9% of the sulfur, which is trapped in the nanofibers. The reaction is mildly endothermic, meaning that net energy production with real reductions in greenhouse emissions are possible. In Phase I research, the feasibility of generating clean fossil fuel derivatives with reduced carbon was demonstrated by the successful design, construction and operation of a facility capable of utilizing coal as well as natural gas as an inlet feedstock. In the case of coal, for example, reductions in CO{sub 2} emissions can be as much as 70% (normalized according to kilowatts produced), with the majority of carbon safely sequestered in the form of carbon nanofibers or coke. Both of these products are value-added commodities, indicating that low-emission coal fuel can be done at a profit rather than a loss as is the case with most clean-up schemes. The main results of this project were as follows: (1) It was shown that the nanofiber production process produces hydrogen as a byproduct. (2) The hydrogen, or hydrogen-rich hydrocarbon mixture can be consumed with net release of enthalpy. (3) The greenhouse gas emissions from both coal and natural gas are significantly reduced. Because coal consumption also creates coke, the carbon emission can be reduced by 75% per kilowatt-hour of power produced.

  19. 7 CFR 1486.500 - What are the reporting requirements of the program?

    Science.gov (United States)

    2010-01-01

    ... MARKETS PROGRAM Reporting, Evaluation, and Compliance § 1486.500 What are the reporting requirements of the program? (a) Performance Reports. (1) Recipients are required to submit regular progress reports...-term report. (2) Final performance reports must be submitted no later than 90 days after completion...

  20. Liquid-Desiccant Vapor Separation Reduces the Energy Requirements of Atmospheric Moisture Harvesting.

    Science.gov (United States)

    Gido, Ben; Friedler, Eran; Broday, David M

    2016-08-02

    An innovative atmospheric moisture harvesting system is proposed, where water vapor is separated from the air prior to cooling and condensation. The system was studied using a model that simulates its three interconnected cycles (air, desiccant, and water) over a range of ambient conditions, and optimal configurations are reported for different operation conditions. Model results were compared to specifications of commercial atmospheric moisture harvesting systems and found to represent saving of 5-65% of the electrical energy requirements due to the vapor separation process. We show that the liquid desiccant separation stage that is integrated into atmospheric moisture harvesting systems can work under a wide range of environmental conditions using low grade or solar heating as a supplementary energy source, and that the performance of the combined system is superior.

  1. 42 CFR 417.126 - Recordkeeping and reporting requirements.

    Science.gov (United States)

    2010-10-01

    ... consistent with prudent management and fiscal soundness requirements. (3) A combined financial statement for... credit. (iii) Goods, services, or facilities furnished for a monetary consideration, including management...) Requirements for combined financial statements. (1) The combined financial statements required by paragraph (b...

  2. 10 CFR 300.9 - Reporting and recordkeeping requirements.

    Science.gov (United States)

    2010-01-01

    ... 300.9 Energy DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL... possible EIA annual report of greenhouse gas emissions reported under this part, entity reports that have... corrected or improved data to EIA, together with an explanation of the significance of the change and...

  3. 77 FR 75439 - Guidances for Industry and Investigators on Safety Reporting Requirements for Investigational New...

    Science.gov (United States)

    2012-12-20

    ... Reporting Requirements for INDs and BA/BE Studies--Small Entity Compliance Guide.'' These guidances are... and BA/BE Studies'' and ``Safety Reporting Requirements for INDs and BA/BE Studies--Small Entity... requirements for IND safety reporting and safety reporting for BA and BE studies. In addition, the Small...

  4. Reducing diagnostic turnaround times of exome sequencing for families requiring timely diagnoses.

    Science.gov (United States)

    Bourchany, Aurélie; Thauvin-Robinet, Christel; Lehalle, Daphné; Bruel, Ange-Line; Masurel-Paulet, Alice; Jean, Nolwenn; Nambot, Sophie; Willems, Marjorie; Lambert, Laetitia; El Chehadeh-Djebbar, Salima; Schaefer, Elise; Jaquette, Aurélia; St-Onge, Judith; Poe, Charlotte; Jouan, Thibaud; Chevarin, Martin; Callier, Patrick; Mosca-Boidron, Anne-Laure; Laurent, Nicole; Lefebvre, Mathilde; Huet, Frédéric; Houcinat, Nada; Moutton, Sébastien; Philippe, Christophe; Tran-Mau-Them, Frédéric; Vitobello, Antonio; Kuentz, Paul; Duffourd, Yannis; Rivière, Jean-Baptiste; Thevenon, Julien; Faivre, Laurence

    2017-08-12

    Whole-exome sequencing (WES) has now entered medical practice with powerful applications in the diagnosis of rare Mendelian disorders. Although the usefulness and cost-effectiveness of WES have been widely demonstrated, it is essential to reduce the diagnostic turnaround time to make WES a first-line procedure. Since 2011, the automation of laboratory procedures and advances in sequencing chemistry have made it possible to carry out diagnostic whole genome sequencing from the blood sample to molecular diagnosis of suspected genetic disorders within 50 h. Taking advantage of these advances, the main objective of the study was to improve turnaround times for sequencing results. WES was proposed to 29 patients with severe undiagnosed disorders with developmental abnormalities and faced with medical situations requiring rapid diagnosis. Each family gave consent. The extracted DNA was sequenced on a NextSeq500 (Illumina) instrument. Data were analyzed following standard procedures. Variants were interpreted using in-house software. Each rare variant affecting protein sequences with clinical relevance was tested for familial segregation. The diagnostic rate was 45% (13/29), with a mean turnaround time of 40 days from reception of the specimen to delivery of results to the referring physician. Besides permitting genetic counseling, the rapid diagnosis for positive families led to two pre-natal diagnoses and two inclusions in clinical trials. This pilot study demonstrated the feasibility of rapid diagnostic WES in our primary genetics center. It reduced the diagnostic odyssey and helped provide support to families. Copyright © 2017. Published by Elsevier Masson SAS.

  5. Levetiracetam reduces myoclonus in corticobasal degeneration: report of two cases.

    Science.gov (United States)

    Kovács, Tibor; Farsang, Marianna; Vitaszil, Edina; Barsi, Péter; Györke, Tamás; Szirmai, Imre; Kamondi, Anita

    2009-12-01

    Levetiracetam (LEV) has been shown to suppress myoclonus of various origins. Corticobasal degeneration (CBD), a progressive neurodegenerative disorder with Parkinsonian syndrome, is frequently accompanied by myoclonus. We investigated the effect of LEV on myoclonus in two CBD patients. LEV remarkably decreased the myoclonic activity in both patients already at 1,500 mg/day dose. This is the first report on LEV alleviating myoclonus in CBD. Our data indicate that it might be worthwhile to assess this effect in an appropriately designed study.

  6. 40 CFR 61.24 - Annual reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... parameters for the computer models (e.g., meteorological data) and the source of these data. (8) Each report... operator shall annually calculate and report the results of the compliance calculations in § 61.23 and the input parameters used in making the calculations. This report shall cover the emissions of a calendar...

  7. 75 FR 57109 - Premerger Notification; Reporting and Waiting Period Requirements

    Science.gov (United States)

    2010-09-17

    ... same line of business as the target. Thus, the Commission proposes to amend the Rules, the Form and the... parties would be required to describe the business the assets being acquired comprise. If there are... bankruptcies under 11 USC Sec. 363 do not require an executed agreement or letter of intent. Items 4-6 Item 4...

  8. 78 FR 55993 - Revisions to Reporting and Recordkeeping Requirements, and Proposed Confidentiality...

    Science.gov (United States)

    2013-09-11

    ... Recordkeeping Requirements, and Proposed Confidentiality Determinations Under the Greenhouse Gas Reporting... and Recordkeeping Requirements, and Proposed Confidentiality Determinations Under the Greenhouse Gas... the Greenhouse Gas Reporting Program. In addition, the EPA is proposing confidentiality determinations...

  9. 49 CFR 22.57 - Loan reporting requirements.

    Science.gov (United States)

    2010-10-01

    ....dot.gov/financial/docs/Loan_Activation_DOT_F_2303-1.pdf. The Participating Lender must also provide....osdbu.dot.gov/financial/docs/Loan_Close-Out_DOT_F_2304-1.pdf. To fulfill this requirement,...

  10. 78 FR 41293 - Premerger Notification; Reporting and Waiting Period Requirements

    Science.gov (United States)

    2013-07-10

    ... hours.\\5\\ See 76 FR ] 42471, 42479 (July 19, 2011). PNO staff believes that this new filing would... transactions (which require ``non-index'' filings), as illustrated by the calculations in footnote 2 above....

  11. Fighting Fire with Fire: Superlattice Cooling of Silicon Hotspots to Reduce Global Cooling Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Biswas, S; Tiwari, M; Sherwood, T; Theogarajan, L; Chong, F T

    2010-10-05

    The running costs of data centers are dominated by the need to dissipate heat generated by thousands of server machines. Higher temperatures are undesirable as they lead to premature silicon wear-out; in fact, mean time to failure has been shown to decrease exponentially with temperature (Black's law). Although other server components also generate heat, microprocessors still dominate in most server configurations and are also the most vulnerable to wearout as the feature sizes shrink. Even as processor complexity and technology scaling have increased the average energy density inside a processor to maximally tolerable levels, modern microprocessors make extensive use of hardware structures such as the load-store queue and other CAM-based units, and the peak temperatures on chip can be much worse than even the average temperature of the chip. In recent studies, it has been shown that hot-spots inside a processor can generate {approx} 800W/cm{sup 2} heat flux whereas the average heat flux is only 10-50W/cm{sup 2}, and due to this disparity in heat generation, the temperature in hot spots may be up to 30 C more than average chip temperature. The key problem processor hot-spots create is that in order to prevent some critical hardware structures from wearing out faster, the air conditioners in a data center have to be provisioned for worst case requirements. Worse yet, air conditioner efficiencies decrease exponentially as the desired ambient temperature decreases relative to the air outside. As a result, the global cooling costs in data centers, which nearly equals the IT equipment power consumption, are directly correlated with the maximum hot spot temperatures of processors, and there is a distinct requirement for a cooling technique to mitigate hot-spots selectively so that the global air conditioners can operate at higher, more efficient, temperatures. We observe that localized cooling via superlattice microrefrigeration presents exactly this opportunity

  12. 49 CFR 40.311 - What are the requirements concerning SAP reports?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false What are the requirements concerning SAP reports... Process § 40.311 What are the requirements concerning SAP reports? (a) As the SAP conducting the required... ensure that you receive SAP written reports directly from the SAP performing the evaluation and that no...

  13. HANDS Deliverable D4.2.1 Requirements Report

    DEFF Research Database (Denmark)

    Aagaard, Morten; Sandborg-Petersen, Ulrik; Schärfe, Henrik;

    This Delivarable contains Aalborg University’ set of requirements. The specification method is use cases. To make it understandable to non-software engineers, a rich introductionary description is given and each part of HANDS toolset is followed by a explanation part.......This Delivarable contains Aalborg University’ set of requirements. The specification method is use cases. To make it understandable to non-software engineers, a rich introductionary description is given and each part of HANDS toolset is followed by a explanation part....

  14. HANDS Deliverable D4.2.1 Requirements Report

    DEFF Research Database (Denmark)

    Aagaard, Morten; Sandborg-Petersen, Ulrik; Schärfe, Henrik

    This Delivarable contains Aalborg University’ set of requirements. The specification method is use cases. To make it understandable to non-software engineers, a rich introductionary description is given and each part of HANDS toolset is followed by a explanation part.......This Delivarable contains Aalborg University’ set of requirements. The specification method is use cases. To make it understandable to non-software engineers, a rich introductionary description is given and each part of HANDS toolset is followed by a explanation part....

  15. 40 CFR 98.316 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Titanium Dioxide Production § 98.316 Data reporting... information specified in paragraphs (a) or (b) of this section, as applicable for each titanium dioxide... calcined petroleum coke (tons). (3) Annual production of titanium dioxide (tons). (4) Annual...

  16. 14 CFR 1260.75 - Summary of report requirements.

    Science.gov (United States)

    2010-01-01

    ... Inventory Report of Federally Owned Property, including equipment where title was taken by the Government... by the government or acquired by the recipient, § 1260.27. The report is due within 60 days after the... electronic or paper version of NASA Form 1679, “Disclosure of Invention and New Technology (Including...

  17. 40 CFR 98.216 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Miscellaneous Uses of Carbonate § 98.216 Data reporting...) Annual CO2 emissions from miscellaneous carbonate use (metric tons). (b) Annual mass of each carbonate... to calculate emissions. (e) If you followed the calculation method of § 98.213(b)(1)(i), you...

  18. 49 CFR 544.5 - General requirements for reports.

    Science.gov (United States)

    2010-10-01

    ...; (7) Include a glossary defining all acronyms and terms of art used in the report, unless those acronyms and terms of art are defined immediately after they first appear in the report; (8) Be submitted in three copies to: Administrator, National Highway Traffic Safety Administration, 400 Seventh Street...

  19. 26 CFR 54.4980F-1 - Notice requirements for certain pension plan amendments significantly reducing the rate of future...

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Notice requirements for certain pension plan... (CONTINUED) PENSION EXCISE TAXES § 54.4980F-1 Notice requirements for certain pension plan amendments... a plan amendment of an applicable pension plan that significantly reduces the rate of future benefit...

  20. Engineered Barrier System performance requirements systems study report. Revision 02

    Energy Technology Data Exchange (ETDEWEB)

    Balady, M.A.

    1997-01-14

    This study evaluates the current design concept for the Engineered Barrier System (EBS), in concert with the current understanding of the geologic setting to assess whether enhancements to the required performance of the EBS are necessary. The performance assessment calculations are performed by coupling the EBS with the geologic setting based on the models (some of which were updated for this study) and assumptions used for the 1995 Total System Performance Assessment (TSPA). The need for enhancements is determined by comparing the performance assessment results against the EBS related performance requirements. Subsystem quantitative performance requirements related to the EBS include the requirement to allow no more than 1% of the waste packages (WPs) to fail before 1,000 years after permanent closure of the repository, as well as a requirement to control the release rate of radionuclides from the EBS. The EBS performance enhancements considered included additional engineered components as well as evaluating additional performance available from existing design features but for which no performance credit is currently being taken.

  1. Importance of Requirements Analysis & Traceability to Improve Software Quality and Reduce Cost and Risk

    Science.gov (United States)

    Kapoor, Manju M.; Mehta, Manju

    2010-01-01

    The goal of this paper is to emphasize the importance of developing complete and unambiguous requirements early in the project cycle (prior to Preliminary Design Phase). Having a complete set of requirements early in the project cycle allows sufficient time to generate a traceability matrix. Requirements traceability and analysis are the key elements in improving verification and validation process, and thus overall software quality. Traceability can be most beneficial when the system changes. If changes are made to high-level requirements it implies that low-level requirements need to be modified. Traceability ensures that requirements are appropriately and efficiently verified at various levels whereas analysis ensures that a rightly interpreted set of requirements is produced.

  2. 41 CFR 101-42.204 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... characteristics of the item are adequately described on a MSDS or HMIS record (or equivalent), the reporting document should so indicate, and a copy of the MSDS or HMIS record shall be included. If no MSDS or HMIS is...

  3. 46 CFR 280.7 - Reporting and recordkeeping requirements.

    Science.gov (United States)

    2010-10-01

    ... operator in the following form: I hereby certify to the best of my knowledge and belief that this report is... the Freedom of Information Act (5 U.S.C. 552). (2) If an operator desires confidential treatment of...

  4. 50 CFR 216.245 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ...) Location of sighting; (B) Species (if not possible—indication of whale/dolphin/pinniped); (C) Number of... AFAST annual report) a brief annual progress update on the status of the development of an effective...

  5. 14 CFR 217.9 - Waivers from reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... PROCEEDINGS) ECONOMIC REGULATIONS REPORTING TRAFFIC STATISTICS BY FOREIGN AIR CARRIERS IN CIVILIAN SCHEDULED... initiative, or upon the submission of a written request of the air carrier to the Director, Office of Airline...

  6. 77 FR 50057 - Premerger Notification; Reporting and Waiting Period Requirements

    Science.gov (United States)

    2012-08-20

    ... manufacturing industry (North American Industry Classification System Industry Group 3254) (``pharmaceutical... reportable. \\3\\ Indeed, the Second Circuit explained in SCM Corp. v. Xerox Corp., `` ince a patent is a...

  7. 78 FR 49324 - Reports, Forms, and Record Keeping Requirements

    Science.gov (United States)

    2013-08-13

    ... 3 was reduced by more than half, to 97,337 vehicles. The trend accelerated over the next five years..., brake fluid, seat belt assemblies, lighting equipment, glazing (i.e., windshield and window glass), motorcycle helmets, child restraints, compressed natural gas containers (used as part of a vehicle fuel...

  8. 77 FR 35473 - Reports, Forms, and Recordkeeping Requirements

    Science.gov (United States)

    2012-06-13

    ... measurement periods = 40,000 total surveys.) The distracted driving program focused on texting behavior will... following proposed collection of information: Title: NHTSA Distracted Driving Survey Project. Type of... conduct awareness surveys to evaluate two traffic safety programs designed to reduce distracted...

  9. 78 FR 25351 - Reports, Forms, and Recordkeeping Requirements

    Science.gov (United States)

    2013-04-30

    ...: Advanced Crash Avoidance Technologies Consumer Research. OMB Control Number: 2127-XXXX. Form Number: None... (23 U.S.C. 101) to carry out a Congressional mandate to reduce the mounting number of deaths, injuries, and economic losses resulting from motor vehicle crashes on the Nation's highways. In support of this...

  10. 78 FR 34154 - Reports, Forms, and Record Keeping Requirements

    Science.gov (United States)

    2013-06-06

    ... a second response mode. The sample would be drawn from driver license databases of States that... reduce the number of deaths, injuries, and economic losses resulting from motor vehicle crashes on the... being the leading cause of death for teenagers in America. It is essential that NHTSA be proactive in...

  11. 50 CFR 216.255 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... section may include retention of marine mammals without the need for a separate scientific research permit... animals sighted. (4) Conduct shipboard monitoring to reduce impacts to protected species. Trained marine..., including the time of sighting and the direction of travel, into a marine animal tracking and...

  12. 33 CFR 169.130 - When are ships required to make reports?

    Science.gov (United States)

    2010-07-01

    ... Reporting Systems for the Protection of Northern Right Whales § 169.130 When are ships required to make reports? Participating ships must report to the shore-based authority upon entering the area covered by...

  13. 76 FR 77999 - Standardizing Program Reporting Requirements for Broadcast Licensees

    Science.gov (United States)

    2011-12-15

    ... the public and broadcasters alike, and the promotion of a dialog between stations and the public they... require broadcasters to air any particular category of programming or mix of programming types. Nor do we... communities.'' 35. We appreciate that NCE licensees have limited resources and that their mix of programming...

  14. 10 CFR 490.507 - Credit activity reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... 490.507 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM... person or fleet applying for allocation of alternative fueled vehicle credits must submit a credit... acquired in model years before the first model year the fleet or covered person is required to...

  15. 75 FR 55629 - Reports, Forms, and Recordkeeping Requirements

    Science.gov (United States)

    2010-09-13

    ... Behavior: 2010 Type of Request--New information collection requirement. OMB Clearance Number--None. Form... collection of information. SUMMARY: Before a Federal agency can collect certain information from the public... established by the Paperwork Reduction Act of 1995, before seeking OMB approval, Federal agencies must solicit...

  16. 78 FR 20039 - Reportable Events and Certain Other Notification Requirements

    Science.gov (United States)

    2013-04-03

    ... Standards (IFRS). This requirement serves to confirm both that the business is successful and that it has... whose financial statements are not prepared using GAAP or IFRS but whose income level is comparable to the standards proposed for this criterion. PBGC seeks suggestions for supplementing the...

  17. 77 FR 2135 - Swap Data Recordkeeping and Reporting Requirements

    Science.gov (United States)

    2012-01-13

    ... Banks (``FHLB'') February 7, 2011 (``CL- FHLB''); (46) Global Foreign Exchange Division (``Global Forex'') February 7, 2011 (``CL-Global Forex''); (47) Green Exchange, LLC (``GreenEx'') June 3, 2011 (``CL-GreenEx... (``Global Forex'') suggested that after termination of the swap, real time access should only be required...

  18. 40 CFR Table 5 of Subpart Bbbbbbb... - Reporting Requirements

    Science.gov (United States)

    2010-07-01

    ... requirement to route all process vent streams from equipment in target HAP service to a PM control device that....11585(c). 2. Certification that all process vent streams from equipment in target HAP service will not... (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Area Sources: Chemical...

  19. 18 CFR 284.13 - Reporting requirements for interstate pipelines.

    Science.gov (United States)

    2010-04-01

    ... a release to a marketer participating in a state-regulated retail access program as defined in § 284... with the pipeline. (c) Index of customers. (1) On the first business day of each calendar quarter, an... customers under contract as of the first day of the calendar quarter that complies with the requirements...

  20. Detectors with Improved Near-to-Mid IR Performance and Reduced Cooling Requirements Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This program will develop an ultra-high performance infrared detector manufacturing technology with improved performance and cost effectiveness, and reduced cooling...

  1. Aestivation and diapause syndromes reduce the water balance requirements for pupae of the Hessian fly, Mayetiola destructor.

    Science.gov (United States)

    We report the water balance of aestivating (summer), diapausing (winter), and non-diapausing pupae of Hessian fly, Mayetiola destructor (Say) (Diptera: Cecidomyiidae). Maintaining water requirements during pupal dormancy is particularly important because water cannot be replenished actively by drink...

  2. Nuclear Physics Science Network Requirements Workshop, May 2008 - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Tierney, Ed., Brian L; Dart, Ed., Eli; Carlson, Rich; Dattoria, Vince; Ernest, Michael; Hitchcock, Daniel; Johnston, William; Kowalski, Andy; Lauret, Jerome; Maguire, Charles; Olson, Douglas; Purschke, Martin; Rai, Gulshan; Watson, Chip; Vale, Carla

    2008-11-10

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the US Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States of America. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In May 2008, ESnet and the Nuclear Physics (NP) Program Office of the DOE Office of Science organized a workshop to characterize the networking requirements of the science programs funded by the NP Program Office. Most of the key DOE sites for NP related work will require significant increases in network bandwidth in the 5 year time frame. This includes roughly 40 Gbps for BNL, and 20 Gbps for NERSC. Total transatlantic requirements are on the order of 40 Gbps, and transpacific requirements are on the order of 30 Gbps. Other key sites are Vanderbilt University and MIT, which will need on the order of 20 Gbps bandwidth to support data transfers for the CMS Heavy Ion program. In addition to bandwidth requirements, the workshop emphasized several points in regard to science process and collaboration. One key point is the heavy reliance on Grid tools and infrastructure (both PKI and tools such as GridFTP) by the NP community. The reliance on Grid software is expected to increase in the future. Therefore, continued development and support of Grid software is very important to the NP science community. Another key finding is that scientific productivity is greatly enhanced by easy researcher-local access to instrument data. This is driving the creation of distributed repositories for instrument data at collaborating institutions, along with a corresponding increase in demand for network-based data transfers and the tools

  3. Nuclear Physics Science Network Requirements Workshop, May 2008 - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Tierney, Ed., Brian L; Dart, Ed., Eli; Carlson, Rich; Dattoria, Vince; Ernest, Michael; Hitchcock, Daniel; Johnston, William; Kowalski, Andy; Lauret, Jerome; Maguire, Charles; Olson, Douglas; Purschke, Martin; Rai, Gulshan; Watson, Chip; Vale, Carla

    2008-11-10

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the US Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States of America. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In May 2008, ESnet and the Nuclear Physics (NP) Program Office of the DOE Office of Science organized a workshop to characterize the networking requirements of the science programs funded by the NP Program Office. Most of the key DOE sites for NP related work will require significant increases in network bandwidth in the 5 year time frame. This includes roughly 40 Gbps for BNL, and 20 Gbps for NERSC. Total transatlantic requirements are on the order of 40 Gbps, and transpacific requirements are on the order of 30 Gbps. Other key sites are Vanderbilt University and MIT, which will need on the order of 20 Gbps bandwidth to support data transfers for the CMS Heavy Ion program. In addition to bandwidth requirements, the workshop emphasized several points in regard to science process and collaboration. One key point is the heavy reliance on Grid tools and infrastructure (both PKI and tools such as GridFTP) by the NP community. The reliance on Grid software is expected to increase in the future. Therefore, continued development and support of Grid software is very important to the NP science community. Another key finding is that scientific productivity is greatly enhanced by easy researcher-local access to instrument data. This is driving the creation of distributed repositories for instrument data at collaborating institutions, along with a corresponding increase in demand for network-based data transfers and the tools

  4. 77 FR 6704 - Exemptions From Entry Requirements and Report of Arrival Requirements for Certain Department of...

    Science.gov (United States)

    2012-02-09

    ... strict security protocols for the conveyances it owns, controls, or charters and for the cargo and... exempt under the relevant authorities. For example, persons on board the conveyance would still be... supplemented by Executive Order 13563, requires Federal agencies to assess the benefits and costs of...

  5. The Danish CSR Reporting Requirement as Reflexive Law

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2013-01-01

    beyond the reach of national law. The article argues that the Danish model for CSR-reporting exemplifies application of reflexive law as a regulatory strategy applied to push company self-regulation in a direction defined by public law standards and policy objectives, in casu particularly human rights...... history and reporting guidelines indicate a definite objective of drawing on the CSR paradigm to complement national substantive law, engaging company practice in the implementation of national public policy goals and in the extraterritorial implementation of public policy goals related to conditions......, labour rights, environment, climate change mitigation and anti-corruption....

  6. Campaign To Reduce Child Poverty. Progress Report [and] Policy Briefs 1-5.

    Science.gov (United States)

    New Mexico Advocates for Children & Families, Albuquerque.

    This document is comprised of a progress report and five policy briefs related to the New Mexico Advocates for Children and Families' Campaign To Reduce Child Poverty. This multi-year initiative educates the public and policymakers about child poverty and promotes public policy changes that would reduce poverty. The progress report presents…

  7. 40 CFR 63.311 - Reporting and recordkeeping requirements.

    Science.gov (United States)

    2010-07-01

    ..., that no coke oven gas was vented, except through the bypass/bleeder stack flare system of a by-product... venting of coke oven gas other than through a flare system. The owner or operator shall report any venting...: (1) Statement signed by the owner or operator, certifying that a bypass/bleeder stack flare system...

  8. 40 CFR 63.655 - Reporting and recordkeeping requirements.

    Science.gov (United States)

    2010-07-01

    ... sampling site description, description of sampling and analysis procedures and any modifications to... of preparation of standards, record of calibrations, raw data sheets for field sampling, raw data... convenience of the user, the revised text is set forth as follows: § 63.655 Reporting and recordkeeping...

  9. 40 CFR 98.176 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... furnace; basic oxygen furnace; non-recovery coke oven battery; sinter process; EAF; argon-oxygen decarburization vessel; and direct reduction furnace: (a) Unit identification number and annual CO2 emissions (in..., and raw steel. (c) If a CEMS is used to measure CO2 emissions, then you must report the...

  10. 40 CFR 60.49b - Reporting and recordkeeping requirements.

    Science.gov (United States)

    2010-07-01

    ... an exceedance due to maintenance of the SO2 control system covered in paragraph 60.45b(a), the report shall identify the days on which the maintenance was performed and a description of the maintenance; (3... system or a predictive emissions monitoring system. (iii) Within 180 days of the completion of...

  11. 75 FR 25033 - Reports, Forms, and Recordkeeping Requirements

    Science.gov (United States)

    2010-05-06

    ... input on alternative prototype features, and obtain guidance on strategies for introduction... reporting of the collected information will use generic categories rather than first names to further... the technology design; and Guide a strategy for introduction of this technology. NHTSA believes...

  12. 40 CFR 98.416 - Data reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) MANDATORY GREENHOUSE GAS REPORTING Suppliers of Industrial Greenhouse Gases § 98.416 Data... producer in practice measures the mass of fluorinated GHGs produced, including the instrumentation used... process, including the instrumentation used (Coriolis flowmeter, other flowmeter, weigh scale, etc.)...

  13. 40 CFR 82.166 - Reporting and recordkeeping requirements.

    Science.gov (United States)

    2010-07-01

    ... PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Recycling and Emissions Reduction § 82.166 Reporting... organizations shall submit to EPA within 30 days of the certification of a new model line of recycling or... under § 82.161 must keep a copy of their certificate at their place of business. (m) All...

  14. 50 CFR 216.155 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ...) Systematic visual observations, by those individuals, described in paragraph (c) of this section, on pinniped... monitoring measures: (1) Visual Land-Based Monitoring. (i) Prior to each missile launch, an observer(s) will... subpart. (5) Both the 60-day and final reports will be subject to review and comment by the...

  15. 50 CFR 218.105 - Requirements for monitoring and reporting.

    Science.gov (United States)

    2010-10-01

    ... Dead Marine Mammals. Navy personnel shall ensure that NMFS is notified immediately ((see Communication... electronic (preferably) or verbal report within fifteen calendar days after the completion of any Major... include the following information as summarized from non-major training exercises (unit-level...

  16. Reduced power processor requirements for the 30-cm diameter HG ion thruster

    Science.gov (United States)

    Rawlin, V. K.

    1979-01-01

    The characteristics of power processors strongly impact the overall performance and cost of electric propulsion systems. A program was initiated to evaluate simplifications of the thruster-power processor interface requirements. The power processor requirements are mission dependent with major differences arising for those missions which require a nearly constant thruster operating point (typical of geocentric and some inbound planetary missions) and those requiring operation over a large range of input power (such as outbound planetary missions). This paper describes the results of tests which have indicated that as many as seven of the twelve power supplies may be eliminated from the present Functional Model Power Processor used with 30-cm diameter Hg ion thrusters.

  17. 12 CFR 204.136 - Treatment of trust overdrafts for reserve requirement reporting purposes.

    Science.gov (United States)

    2010-01-01

    ... requirement reporting purposes. 204.136 Section 204.136 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RESERVE REQUIREMENTS OF DEPOSITORY INSTITUTIONS (REGULATION D) Interpretations § 204.136 Treatment of trust overdrafts for reserve requirement reporting purposes. (a)...

  18. 75 FR 62515 - Notice of Availability of Report on the Communications Requirements of Smart Grid Technologies

    Science.gov (United States)

    2010-10-12

    ... of Availability of Report on the Communications Requirements of Smart Grid Technologies AGENCY..., ``Communications Requirements of Smart Grid Technologies.'' In this report, DOE sets forth recommendations and observations on current and potential communications requirements of the Smart Grid, as well as the types of...

  19. Reduced order models for thermal analysis : final report : LDRD Project No. 137807.

    Energy Technology Data Exchange (ETDEWEB)

    Hogan, Roy E., Jr.; Gartling, David K.

    2010-09-01

    This LDRD Senior's Council Project is focused on the development, implementation and evaluation of Reduced Order Models (ROM) for application in the thermal analysis of complex engineering problems. Two basic approaches to developing a ROM for combined thermal conduction and enclosure radiation problems are considered. As a prerequisite to a ROM a fully coupled solution method for conduction/radiation models is required; a parallel implementation is explored for this class of problems. High-fidelity models of large, complex systems are now used routinely to verify design and performance. However, there are applications where the high-fidelity model is too large to be used repetitively in a design mode. One such application is the design of a control system that oversees the functioning of the complex, high-fidelity model. Examples include control systems for manufacturing processes such as brazing and annealing furnaces as well as control systems for the thermal management of optical systems. A reduced order model (ROM) seeks to reduce the number of degrees of freedom needed to represent the overall behavior of the large system without a significant loss in accuracy. The reduction in the number of degrees of freedom of the ROM leads to immediate increases in computational efficiency and allows many design parameters and perturbations to be quickly and effectively evaluated. Reduced order models are routinely used in solid mechanics where techniques such as modal analysis have reached a high state of refinement. Similar techniques have recently been applied in standard thermal conduction problems e.g. though the general use of ROM for heat transfer is not yet widespread. One major difficulty with the development of ROM for general thermal analysis is the need to include the very nonlinear effects of enclosure radiation in many applications. Many ROM methods have considered only linear or mildly nonlinear problems. In the present study a reduced order model is

  20. A report on NASA software engineering and Ada training requirements

    Science.gov (United States)

    Legrand, Sue; Freedman, Glenn B.; Svabek, L.

    1987-01-01

    NASA's software engineering and Ada skill base are assessed and information that may result in new models for software engineering, Ada training plans, and curricula are provided. A quantitative assessment which reflects the requirements for software engineering and Ada training across NASA is provided. A recommended implementation plan including a suggested curriculum with associated duration per course and suggested means of delivery is also provided. The distinction between education and training is made. Although it was directed to focus on NASA's need for the latter, the key relationships to software engineering education are also identified. A rationale and strategy for implementing a life cycle education and training program are detailed in support of improved software engineering practices and the transition to Ada.

  1. Reducing Tobacco Use. A report of the Surgeon General. Executive Summary.

    Science.gov (United States)

    2000-12-22

    action plan for improving the health of all people living in the United States for the first decade of the 21st century (U.S. Department of Health and Human Services [USDHHS] 2000a). Twenty-one specific national health objectives related to tobacco use are listed in Healthy People 2010, including reducing the rates among young people and adults to less than half of the current rate of use. Attaining all of these tobacco-related objectives will almost certainly require significant national commitment to the various successful approaches described in this report. The major conclusions of this report are not formal policy recommendations. Rather, they offer a summary of the scientific literature about what works. In short, this report is intended to offer policymakers, public health professionals, professional and advocacy organizations, researchers, and, most importantly, the American people guidance on how to ensure that efforts to prevent and control tobacco use are commensurate with the harm it causes.

  2. 40 CFR 166.50 - Reporting and recordkeeping requirements for crisis exemption.

    Science.gov (United States)

    2010-07-01

    ... requirements for crisis exemption. 166.50 Section 166.50 Protection of Environment ENVIRONMENTAL PROTECTION... EMERGENCY CONDITIONS Crisis Exemptions § 166.50 Reporting and recordkeeping requirements for crisis... a crisis exemption must be immediately reported to the Agency. (b) Final reports. (1) A...

  3. 50 CFR 86.80 - What are my reporting requirements for this grant program?

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are my reporting requirements for..., DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT (BIG) PROGRAM Reporting Requirements for the States § 86.80 What are my reporting...

  4. Reducing Tobacco Use: A Report of the Surgeon General [and] Executive Summary.

    Science.gov (United States)

    Center for Chronic Disease Prevention and Health Promotion (DHHS/CDC), Atlanta, GA.

    This report offers a composite review of methods used to prevent tobacco use. The report evaluates five approaches currently used to reduce tobacco consumption: educational, clinical, regulatory, economic, and comprehensive approaches. The report explains these approaches in terms of the larger context of tobacco control and provides a vision for…

  5. 77 FR 26824 - Agency Information Collection; Activity Under OMB Review; Reporting Required for International...

    Science.gov (United States)

    2012-05-07

    ...; Reporting Required for International Civil Aviation Organization (ICAO) AGENCY: Research & Innovative... Required for International Civil Aviation Organization (ICAO). Form No.: BTS Form EF. Type of Review... Convention on International Civil Aviation (Treaty), the United States is obligated to provide ICAO...

  6. Reducing the number of required beds by rearranging the OR-schedule

    NARCIS (Netherlands)

    van Essen, J. Theresia; Bosch, Joël M.; Hans, Elias W.; van Houdenhoven, Mark; Hurink, Johann L.

    After surgery most of the surgical patients have to be admitted in a ward in the hospital. Due to financial reasons and a decreasing number of available nurses in the Netherlands over the years, it is important to reduce the bed usage as much as possible. One possible way to achieve this is to

  7. Does work-related training reduce the discrepancy between function requirements and competencies?

    NARCIS (Netherlands)

    E.R. Kappe; G.E. Bijwaard (Govert)

    2005-01-01

    textabstractThe issue of lifelong learning is high on the political agenda. However, despite this political interest and the large economic literature on human capital, the impact of work-related training on the discrepancy between function requirements and the skills of the employee has been ignore

  8. 26 CFR 1.121-3 - Reduced maximum exclusion for taxpayers failing to meet certain requirements.

    Science.gov (United States)

    2010-04-01

    ... requirements of this section are satisfied depends upon all the facts and circumstances. Factors that may be... his house to take a 3-year assignment in Germany. B sells his house in January 2004. Because B's new place of employment in Germany is at least 50 miles farther from the residence sold than is B's former...

  9. 50 CFR 84.12 - What are the information collection, record keeping, and reporting requirements?

    Science.gov (United States)

    2010-10-01

    ...-2179); (4) Assurances of compliance with all applicable Federal laws, regulations, and policies (SF..., threatened and endangered species, and migratory birds) have benefited? (c) Reporting requirements include...

  10. Tranexamic acid reduces the blood loss and blood transfusion requirements following peri-acetabular osteotomy.

    Science.gov (United States)

    Wassilew, G I; Perka, C; Janz, V; Krämer, M; Renner, L

    2015-12-01

    We have investigated the effect of using tranexamic acid (TXA) during peri-acetabular osteotomy (PAO) on peri-operative blood loss and blood transfusion requirements. In addition we analysed whether the use of TXA was associated with an increased risk of venous thromboembolism (VTE) following this procedure. A consecutive series of 96 PAOs, performed by a single surgeon, were reviewed. A total of 48 patients received TXA and 48 did not. The TXA group received a continuous infusion of TXA at a rate of 10 mg/kg/h. The primary outcome measure was the requirement for blood transfusion. Secondary outcomes included total blood loss, the decrease in the level of haemoglobin in the blood, the length of hospital stay, and the complications of this treatment. The mean rate of transfusion was significantly lower in the TXA group (62.5% vs 12.5%, p transfusion after PAO significantly, without adverse effects such as an increased rate of VTE.

  11. Parental Guidance Required: How Parents Could Help Reduce the Shortage of Minority Physician Assistants.

    Science.gov (United States)

    Scarbrough, Amanda W; Xie, Yue; Shelton, Steve R

    2017-09-01

    Physician assistants (PAs) are essential to the health care system, and there are not nearly enough of them to meet the needs of our ethnically diverse population. Factors contributing to a lack of minorities in PA schools are related to academic performance, commitments outside work/school, and social and economic deprivation. From 2014 to 2016, the Texas Area Health Education Center East worked with the University of Texas Medical Branch at Galveston to implement Physician Assistant Learner Support programming. This program, targeting minority high school students, promoted and educated both students and parents about PA careers with the objective of alleviating one of the main barriers to minority higher education-lack of understanding of educational and career opportunities. This study found that parental knowledge about PA application requirements, PA degree requirements, financial aid, and career prospects at the high school level is essential to securing parental support of student selection of PA careers.

  12. 77 FR 72993 - Atlantic Highly Migratory Species; Electronic Dealer Reporting Requirements; Correction

    Science.gov (United States)

    2012-12-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE... Species; Electronic Dealer Reporting Requirements; Correction AGENCY: National Marine Fisheries Service... final regulations regarding electronic dealer reporting, which published August 8, 2012, with an...

  13. 76 FR 42567 - Reporting Requirements for U.S. Providers of International Telecommunications Services

    Science.gov (United States)

    2011-07-19

    ... Telecommunications Services AGENCY: Federal Communications Commission. ACTION: Final rule. SUMMARY: In this document... unnecessary reporting requirements related to international telecommunications traffic for which the burdens... international telecommunications services. In the First Report and Order portion of the document, the...

  14. 78 FR 7484 - Insurer Reporting Requirements; Reports Under 49 U.S.C. on Section 33112(c)

    Science.gov (United States)

    2013-02-01

    ... National Highway Traffic Safety Administration Insurer Reporting Requirements; Reports Under 49 U.S.C. on Section 33112(c) AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of... 33112(c), this report provides information on theft and recovery of vehicles; rating rules and plans...

  15. Risk-informed assessment of regulatory and design requirements for future nuclear power plants. Annual report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-08-01

    OAK B188 Risk-informed assessment of regulatory and design requirements for future nuclear power plants. Annual report. The overall goal of this research project is to support innovation in new nuclear power plant designs. This project is examining the implications, for future reactors and future safety regulation, of utilizing a new risk-informed regulatory system as a replacement for the current system. This innovation will be made possible through development of a scientific, highly risk-formed approach for the design and regulation of nuclear power plants. This approach will include the development and/or confirmation of corresponding regulatory requirements and industry standards. The major impediment to long term competitiveness of new nuclear plants in the U.S. is the capital cost component--which may need to be reduced on the order of 35% to 40% for Advanced Light Water Reactors (ALWRS) such as System 80+ and Advanced Boiling Water Reactor (ABWR). The required cost reduction for an ALWR such as AP600 or AP1000 would be expected to be less. Such reductions in capital cost will require a fundamental reevaluation of the industry standards and regulatory bases under which nuclear plants are designed and licensed. Fortunately, there is now an increasing awareness that many of the existing regulatory requirements and industry standards are not significantly contributing to safety and reliability and, therefore, are unnecessarily adding to nuclear plant costs. Not only does this degrade the economic competitiveness of nuclear energy, it results in unnecessary costs to the American electricity consumer. While addressing these concerns, this research project will be coordinated with current efforts of industry and NRC to develop risk-informed, performance-based regulations that affect the operation of the existing nuclear plants; however, this project will go further by focusing on the design of new plants.

  16. High-pressure discharges with imposed stability resulting in reduced power requirements

    Science.gov (United States)

    Brooks, N. H.; Jensen, T. H.; Moeller, C. M.

    2003-08-01

    High-pressure plasma discharge columns that are long and straight, as well as uniform in the axial direction, have been generated in a steady state. These discharges, stabilized by rotation of the containment envelope about a horizontal axis, have reduced heat transport to the wall due to the absence of buoyancy-driven radial convection and the elimination of eddies caused by sheared flow. These "rotating tube discharges" may take the form of electric arcs powered with dc or low-frequency ac; or of electrodeless plasmas, heated by electromagnetic waves at rf or microwave frequencies.

  17. Research requirements to reduce empty weight of helicopters by use of advanced materials

    Science.gov (United States)

    Hoffstedt, D. J.

    1976-01-01

    Utilization of the new, lightweight, high-strength, aerospace structural-composite (filament/matrix) materials, when specifically designed into a new aircraft, promises reductions in structural empty weight of 12 percent at recurring costs competive with metals. A program of basic and applied research and demonstration is identified with the objective of advancing the state of the art to the point where civil helicopters are confidently designed, produced, certified, and marketed by 1985. A structural empty-weight reduction of 12 percent was shown to significantly reduce energy consumption in modern high-performance helicopters.

  18. Seasonal acclimation in metabolism reduces light requirements of eelgrass (Zostera marina)

    DEFF Research Database (Denmark)

    Stæhr, Peter A.; Borum, Jens

    2011-01-01

    We investigated the ability of eelgrass (Zostera marina) to adjust light requirements to seasonal changes in temperature, light and nutrient conditions through changes in metabolism, pigment and nutrient content. In agreement with expectations we found that rates of respiration and light saturated...... photosynthesis of summer acclimated plants peaked at higher temperatures (5 °C and 2 °C higher, respectively), and were lower than of winter acclimated plants, both at sub- and supra-optimal temperatures. Moreover respiration rates were generally more sensitive to increasing temperatures than photosynthetic...

  19. 40 CFR Table 6 to Subpart Lllll of... - Requirements for Reports

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 13 2010-07-01 2010-07-01 false Requirements for Reports 6 Table 6 to Subpart LLLLL of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Manufacturing Pt. 63, Subpt. LLLLL, Table 6 Table 6 to Subpart LLLLL of Part 63—Requirements for Reports You...

  20. 75 FR 72877 - Pipeline Safety: Updates to Pipeline and Liquefied Natural Gas Reporting Requirements

    Science.gov (United States)

    2010-11-26

    ... Safety: Updates to Pipeline and Liquefied Natural Gas Reporting Requirements; Final Rule #0;#0;Federal... to Pipeline and Liquefied Natural Gas Reporting Requirements AGENCY: Pipeline and Hazardous Materials... collections from operators of natural gas pipelines, hazardous liquid pipelines, and liquefied natural......

  1. 30 CFR 77.216-4 - Water, sediment or slurry impoundments and impounding structures; reporting requirements...

    Science.gov (United States)

    2010-07-01

    ....216-4 Water, sediment or slurry impoundments and impounding structures; reporting requirements... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Water, sediment or slurry impoundments and impounding structures; reporting requirements; certification. 77.216-4 Section 77.216-4 Mineral...

  2. 5 CFR 2634.205 - Special waiver of public reporting requirements.

    Science.gov (United States)

    2010-01-01

    ... EXECUTIVE BRANCH FINANCIAL DISCLOSURE, QUALIFIED TRUSTS, AND CERTIFICATES OF DIVESTITURE Persons Required To File Public Financial Disclosure Reports § 2634.205 Special waiver of public reporting requirements. (a... interest; and (4) Public financial disclosure by the individual is not necessary under the...

  3. 9 CFR 11.41 - Reporting required of horse industry organizations or associations.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Reporting required of horse industry... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE HORSE PROTECTION REGULATIONS § 11.41 Reporting required of horse industry organizations or associations. Each horse industry organization or...

  4. 40 CFR 80.1152 - What are the reporting requirements under the RFS program?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What are the reporting requirements... What are the reporting requirements under the RFS program? (a) Any obligated party described in § 80... corporate (aggregate) or facility-by-facility basis. (iv) The EPA facility registration number, if...

  5. 49 CFR 579.26 - Reporting requirements for manufacturers of tires.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Reporting requirements for manufacturers of tires... requirements for manufacturers of tires. For each reporting period, a manufacturer (including a brand name... in interstate commerce, or imported tires in the United States shall submit the information...

  6. 40 CFR Table 9 to Subpart Jjj of... - Routine Reports Required by This Subpart

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Routine Reports Required by This Subpart 9 Table 9 to Subpart JJJ of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY.... 63, Subpt. JJJ, Table 9 Table 9 to Subpart JJJ of Part 63—Routine Reports Required by This Subpart...

  7. 75 FR 20269 - Regulatory Reporting Requirements for the Indian Community Development Block Grant Program

    Science.gov (United States)

    2010-04-19

    ... Indian Community Development Block Grants (ICDBG) program. First, the rule provides for submission of a... reporting requirements for the Indian Community Development Block Grant (ICDBG) program. The purpose of the... HUD-96010 a mandatory reporting requirement for ICDBG grant funding. As more fully described in...

  8. 30 CFR 285.712 - What are the CVA's or project engineer's reporting requirements?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What are the CVA's or project engineer's... CVA's or project engineer's reporting requirements? (a) The CVA or project engineer must prepare and submit to you and MMS all reports required by this subpart. The CVA or project engineer must also submit...

  9. 77 FR 47914 - Reports, Forms and Recordkeeping Requirements Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2012-08-10

    ...) abstracted below has been forwarded to the Office of Management and Budget (OMB) for review and comment. The... collection of information described is the ``Roof Crush Resistance Phase in Reporting Requirements--Part 585... Traffic Safety Administration Title: Roof Crush Resistance Phase in Reporting Requirements--Part 585. OMB...

  10. 47 CFR 54.209 - Annual reporting requirements for designated eligible telecommunications carriers.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Annual reporting requirements for designated eligible telecommunications carriers. 54.209 Section 54.209 Telecommunication FEDERAL COMMUNICATIONS... Service Support § 54.209 Annual reporting requirements for designated eligible telecommunications...

  11. The structural requirements of organophosphorus insecticides (OPI) for reducing chicken embryo NAD(+) content in OPI-induced teratogenesis in chickens.

    Science.gov (United States)

    Seifert, Josef

    2016-05-01

    The objective of this study was to determine the structural requirements of organophosphorus insecticides (OPI) for reducing chicken embryo nicotinamide adenine dinucleotide (NAD(+)) content in OPI-induced teratogenesis and compare them with those needed for OPI inhibition of yolk sac membrane kynurenine formamidase (KFase), the proposed primary target for OPI teratogens in chicken embryos. The comparative molecular field analysis (COMFA) of three-dimensional quantitative structure-activity relationship (3D QSAR) revealed the electrostatic and steric fields as good predictors of OPI structural requirements to reduce NAD(+) content in chicken embryos. The dominant electrostatic interactions were localized at nitrogen-1, nitrogen-3, nitrogen of 2-amino substituent of the pyrimidinyl of pyrimidinyl phosphorothioates, and at the oxygen of crotonamide carbonyl in crotonamide phosphates. Bulkiness of the substituents at carbon-6 of the pyrimidinyls and/or N-substituents of crotonamides was the steric structural component that contributed to superiority of those OPI for reducing embryonic NAD(+) levels. Both electrostatic and steric requirements are similar to those defined in our previous study for OPI inhibition of chicken embryo yolk sac membrane KFase. The findings of this study provide another piece of evidence for the cause-and-effect relationship between yolk sac membrane KFase inhibition and reduced embryo NAD(+) content in NAD-associated OPI-induced teratogenesis in chickens.

  12. 20 CFR 411.395 - Is a State VR agency required to provide periodic reports?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Is a State VR agency required to provide... § 411.395 Is a State VR agency required to provide periodic reports? (a) For cases where a State VR agency provided services functioning as an EN, the State VR agency will be required to prepare periodic...

  13. Genetic and environmental influences on self-reported reduced hearing in the old and oldest old

    DEFF Research Database (Denmark)

    Christensen, Kaare; Frederiksen, H; Hoffman, H J

    2001-01-01

    : The prevalence of self-reported reduced hearing corresponded to previous studies and showed the expected age and sex dependence. Concordance rates, odds ratios, and correlations were consistently higher for monozygotic twin pairs than for dizygotic twin pairs in all age and sex categories, indicating heritable......-reported reduced hearing in both men and women age 70 and older. Because self-reports of reduced hearing involve misclassification, this estimate of the genetic influence on hearing disabilities is probably conservative. Hence, genetic and environmental factors play a substantial role in reduced hearing among...... the old and oldest old. This suggests that clinical epidemiological studies of age-related hearing loss should include not only information on environmental exposures but also on family history of hearing loss and, if possible, biological samples for future studies of candidate genes for hearing loss....

  14. Decreasing the critical value of hemoglobin required for physician notification reduces the rate of blood transfusions

    Directory of Open Access Journals (Sweden)

    Larson EA

    2016-06-01

    Full Text Available Eric A Larson,1 Paul A Thompson,1,2 Zachary K Anderson,3 Keith A Anderson,4 Roxana A Lupu,1 Vicki Tigner,5 Wendell W Hoffman6,7 1Department of Internal Medicine, 2Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, 3Department of Internal Medicine, Fairview Health Services, Edina, MN, 4Department of Laboratory Medicine, Sanford School of Medicine, University of South Dakota, 5Medical Staff Services, 6Department of Infectious Disease, Sanford Health, Sanford USD Medical Center, 7Department of Infectious Disease, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USAAbstract: Red blood cell transfusions have been cited as one of the most overused therapeutic interventions in the USA. Excessively aggressive transfusion practices may be driven by mandatory physician notification of critical hemoglobin values that do not generally require transfusion. We examined the effect of decreasing the critical value of hemoglobin from 8 to 7 g/dL at our institution. Along with this change, mandatory provider notification for readings between 7 and 8 g/dL was rescinded. Transfusion rates were compared retrospectively during paired 5-month periods for patients presenting in three key hemoglobin ranges (6.00–6.99, 7.00–7.99, and 8.00–8.99 g/dL. A change in transfusion practices was hypothesized in the 7–8 g/dL range, which was no longer labeled critical and for which mandated physician calls were rescinded. Transfusion rates showed a statistically significant 8% decrease (P≤0.0001 during the 5-month period post change in our transfusion practices. This decrease in the 7.00–7.99 g/dL range was significantly greater than the 2% decrease observed in either the 6–6.99 g/dL (P=0.0017 or 8–8.99 g/dL (P≤0.0001 range. Cost savings of up to $700,000/year were extrapolated from our results showing 491 fewer units of red blood cells transfused during the 5-month post change. These cost

  15. An anaesthetic pre-operative assessment clinic reduces pre-operative inpatient stay in patients requiring major vascular surgery.

    LENUS (Irish Health Repository)

    O'Connor, D B

    2012-02-01

    BACKGROUND: Patients undergoing major vascular surgery (MVS) require extensive anaesthetic assessment. This can require extended pre-operative stays. AIMS: We investigated whether a newly established anaesthetic pre-operative assessment clinic (PAC) would reduce the pre-operative inpatient stay, avoid unnecessary investigations and facilitate day before surgery (DBS) admissions for patients undergoing MVS. PATIENT AND METHODS: One year following and preceding the establishment of the PAC the records of patients undergoing open or endovascular aortic aneurysm repair, carotid endarterectomy and infra-inguinal bypass were reviewed to measure pre-operative length of stay (LoS). RESULTS: Pre-operative LoS was significantly reduced in the study period (1.85 vs. 4.2 days, respectively, P < 0.0001). Only 12 out of 61 patients in 2007 were admitted on the DBS and this increased to 33 out of 63 patients (P = 0.0002). No procedure was cancelled for medical reasons. CONCLUSION: The PAC has facilitated accurate outpatient anaesthetic assessment for patients requiring MVS. The pre-operative in-patient stay has been significantly reduced.

  16. 46 CFR 67.321 - Requirement to report change of address of managing owner.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Requirement to report change of address of managing... report change of address of managing owner. Upon the change of address of the managing owner of a documented vessel, the managing owner shall report the change of address to the National Vessel Documentation...

  17. 45 CFR 287.60 - Are there additional financial reporting and auditing requirements?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Are there additional financial reporting and... there additional financial reporting and auditing requirements? (a) The reporting of expenditures are... comply with all laws, regulations, and Departmental policies that govern submission of financial...

  18. 50 CFR 300.183 - Permit holder reporting and recordkeeping requirements.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Permit holder reporting and recordkeeping... Species § 300.183 Permit holder reporting and recordkeeping requirements. (a) Biweekly reports. Any person..., retained, or submitted pursuant to this subpart. A permit holder must allow NMFS or an authorized person...

  19. 77 FR 64077 - National Highway-Rail Crossing Inventory Reporting Requirements

    Science.gov (United States)

    2012-10-18

    ... Inventory Reporting Section 234.401 Definitions This section contains proposed definitions of terms used in... use this definition for Crossing Inventory reporting purposes as well. With respect to crossings in...)(3) of this section would require that the reporting entity and the primary operating...

  20. A COMPARATIVE STUDY SHOWING EFFICACY OF PREEMPTIVE INTRAVENOUS PARACETAMOL IN REDUCING POSTOPERATIVE PAIN AND ANALGESIC REQUIREMENT IN LAPAROSCOPIC CHOLECYSTECTOMY

    Directory of Open Access Journals (Sweden)

    Aftab Ahmad

    2015-07-01

    Full Text Available A double blind, prospective, randomized study was conducted on 60 patients of ASA I and II undergoing laparoscopic cholecystectomy to evaluate the efficacy of pre - emptive IV paracetamol [PCM] in reducing postoperative pain and analgesic requirement. Patien ts were randomly assigned in two groups, group A and group B of which group A received pre - emptive IV PCM 10 minutes before skin incision. It was observed that time to first analgesic required was significantly longer in group A as compared to group B and group A had significantly lower total analgesic consumption and visual analogue scores (VAS as compared to group B. We concluded that pre - emptive use of IV PCM (Paracetamol in laparoscopic cholecystectomy significantly decreases postoperative pain and a nalgesic requirement.

  1. 77 FR 13131 - Proposed Collection: Comment Request Post-Award Reporting Requirements Including New Research...

    Science.gov (United States)

    2012-03-05

    ... required to report annually. Affected Public: Universities and other research institutions; Business or... of the methodology and assumptions used; (3) ways to enhance the quality, utility, and clarity of the...

  2. 76 FR 52253 - Revisions to Forms, Statements, and Reporting Requirements for Natural Gas Pipelines

    Science.gov (United States)

    2011-08-22

    ..., billing determinants, rate components and surcharges. But, the Commission does not require that fuel used... discounting fuel then it should simply report zero in Column (K), Volume (in Dth) Not Collected. This...

  3. A guide to California's breaches. First year of state reporting requirement reveals common privacy violations.

    Science.gov (United States)

    Dimick, Chris

    2010-04-01

    Effective January 1, 2009, California healthcare providers were required to report every breach of patient information to the state. They have sent a flood of mishaps and a steady stream of malicious acts.

  4. 77 FR 35199 - Swap Data Recordkeeping and Reporting Requirements: Pre-Enactment and Transition Swaps

    Science.gov (United States)

    2012-06-12

    ... Exchange Division (``Global Forex'') recommended that the requirement to report PET data should be limited..., complicating the compilation task of the SDRs. Both ISDA and Global Forex requested that the Commission...

  5. 75 FR 55628 - National Highway Traffic Safety Administration Reports, Forms and Record Keeping Requirements...

    Science.gov (United States)

    2010-09-13

    ... National Highway Traffic Safety Administration Reports, Forms and Record Keeping Requirements: Agency Information Collection Activity Under OMB Review AGENCY: National Highway Traffic Safety Administration (NHTSA... National Highway Traffic Safety Administration (NHTSA), Office of Crash Avoidance Standards...

  6. 76 FR 42613 - Reporting Requirements for U.S. Providers of International Telecommunications Services

    Science.gov (United States)

    2011-07-19

    ... Telecommunications Services AGENCY: Federal Communications Commission. ACTION: Proposed rule. SUMMARY: In this... providers of international telecommunications services. The Commission proposes to amend its reporting requirements for providers of international telecommunications services and transmission facilities in order...

  7. 19 CFR 4.4 - Panama Canal; report of arrival required.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Panama Canal; report of arrival required. 4.4 Section 4.4 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY VESSELS IN FOREIGN AND DOMESTIC TRADES Arrival and Entry of Vessels § 4.4 Panama Canal; report of arrival required. Vessels...

  8. Report: Early Warning Report: Main EPA Headquarters Warehouse in Landover, Maryland, Requires Immediate EPA Attention

    Science.gov (United States)

    Report #13-P-0272, May 31, 2013. Our initial research at the EPA’s Landover warehouse raised significant concerns with the lack of agency oversight of personal property and warehouse space at the facility.

  9. 76 FR 69204 - Anti-Money Laundering Program and Suspicious Activity Reporting Requirements for Housing...

    Science.gov (United States)

    2011-11-08

    ... Financial Crimes Enforcement Network 31 CFR Parts 1010 and 1030 RIN 1506-AB14 Anti-Money Laundering Program... requiring them to establish anti-money laundering programs and report suspicious activities pursuant to the Bank Secrecy Act. The proposal to require these organizations to establish anti-money laundering...

  10. 77 FR 8148 - Anti-Money Laundering Program and Suspicious Activity Report Filing Requirements for Residential...

    Science.gov (United States)

    2012-02-14

    ... Financial Crimes Enforcement Network 31 CFR Parts 1010 and 1029 RIN 1506-AB02 Anti-Money Laundering Program... requiring them to establish anti-money laundering programs and report suspicious activities under the Bank... impose anti-money laundering (``AML'') program requirements on financial institutions.\\3\\ The authority...

  11. 26 CFR 1.6031(b)-2T - REMIC reporting requirements (temporary). [Reserved

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false REMIC reporting requirements (temporary). 1.6031(b)-2T Section 1.6031(b)-2T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... requirements (temporary)....

  12. 40 CFR 166.32 - Reporting and recordkeeping requirements for specific, quarantine, and public health exemptions.

    Science.gov (United States)

    2010-07-01

    ... requirements for specific, quarantine, and public health exemptions. 166.32 Section 166.32 Protection of... AGENCIES FOR USE OF PESTICIDES UNDER EMERGENCY CONDITIONS Specific, Quarantine, and Public Health Exemptions § 166.32 Reporting and recordkeeping requirements for specific, quarantine, and public health...

  13. 78 FR 51078 - Reporting Requirements for Positive Train Control Expenses and Investments

    Science.gov (United States)

    2013-08-20

    ... Accounting and Financial Reporting--Transportation of Hazardous Materials, Docket No. EP 681, the Board is... the R-1 to require financial disclosure with respect to PTC to help inform the Board and the public... authorized by this provision, the Board requires large (Class I) \\1\\ rail carriers to submit annual...

  14. Improving Ocean Color Data Products using a Purely Empirical Approach: Reducing the Requirement for Radiometric Calibration Accuracy

    Science.gov (United States)

    Gregg, Watson

    2008-01-01

    Radiometric calibration is the foundation upon which ocean color remote sensing is built. Quality derived geophysical products, such as chlorophyll, are assumed to be critically dependent upon the quality of the radiometric calibration. Unfortunately, the goals of radiometric calibration are not typically met in global and large-scale regional analyses, and are especially deficient in coastal regions. The consequences of the uncertainty in calibration are very large in terms of global and regional ocean chlorophyll estimates. In fact, stability in global chlorophyll requires calibration uncertainty much greater than the goals, and outside of modern capabilities. Using a purely empirical approach, we show that stable and consistent global chlorophyll values can be achieved over very wide ranges of uncertainty. Furthermore, the approach yields statistically improved comparisons with in situ data, suggesting improved quality. The results suggest that accuracy requirements for radiometric calibration cab be reduced if alternative empirical approaches are used.

  15. Endocarditis caused by methicillin-susceptible Staphylococcus aureus with reduced susceptibility to vancomycin: a case report

    Directory of Open Access Journals (Sweden)

    Famiglietti Angela

    2011-07-01

    Full Text Available Abstract Introduction Staphylococcus aureus is the most common cause of acute infective endocarditis. Recent reports have described heteroresistance to vancomycin associated with methicillin-resistant Staphylococcus aureus. We present the first case report in Argentina of the failure of treatment with vancomycin in endocarditis caused by methicillin-susceptible Staphylococcus aureus containing subpopulations with reduced susceptibility to vancomycin. Case presentation We report the case of a 66-year-old Hispanic man with infective endocarditis complicated by septic emboli in the lumbosacral spine and the left iliopsoas muscle. This disease was caused by methicillin-susceptible Staphylococcus aureus containing subpopulations with reduced susceptibility to vancomycin. He was initially treated with cephalothin and gentamicin but developed a rash caused by beta-lactams and interstitial nephritis. For that reason, the treatment was subsequently switched to vancomycin but he failed to respond. The infection resolved after administration of vancomycin in combination with gentamicin and rifampin. Conclusion Our case report provides important evidence for the existence of subpopulations of methicillin-susceptible Staphylococcus aureus that have reduced susceptibility to vancomycin which would account for treatment failure. Our case raises an alert about the existence of these strains and highlights the need to determine the vancomycin minimum inhibitory concentration of Staphylococcus aureus to screen for the presence of strains that have reduced vancomycin susceptibility at different infection sites.

  16. Mindfulness significantly reduces self-reported levels of anxiety and depression

    DEFF Research Database (Denmark)

    Würtzen, Hanne; Dalton, Susanne Oksbjerg; Elsass, Peter

    2013-01-01

    INTRODUCTION: As the incidence of and survival from breast cancer continue to raise, interventions to reduce anxiety and depression before, during and after treatment are needed. Previous studies have reported positive effects of a structured 8-week group mindfulness-based stress reduction program...

  17. Increasing Marriage Will Dramatically Reduce Child Poverty. A Report of the Heritage Center for Data Analysis.

    Science.gov (United States)

    Rector, Robert E.; Johnson, Kirk A.; Fagan, Patrick F.; Noyes, Lauren R.

    This report uses data from the Fragile Families and Child Well-Being Study (a nationwide survey that collects data on married and non-married parents at the time of the child's birth) to determine how much marriage could reduce poverty among couples who are not married at the time of birth. To determine the impact of marriage on children's and…

  18. Parasitic fibroid: case report and novel approach in reducing incidence of future cases

    Directory of Open Access Journals (Sweden)

    Sukainah S.

    2016-08-01

    Full Text Available We report a case of parasitic fibroid which developed less than 1 year following laparoscopic myomectomy using power morcellation. Following this case, a novel approach in reducing the incidence of future parasitic fibroid is described. [Int J Reprod Contracept Obstet Gynecol 2016; 5(8.000: 2836-2839

  19. 17 CFR 1.15 - Risk assessment reporting requirements for futures commission merchants.

    Science.gov (United States)

    2010-04-01

    ... exposure reports filed by such Material Affiliated Person with a foreign futures authority or other foreign... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Risk assessment reporting requirements for futures commission merchants. 1.15 Section 1.15 Commodity and Securities Exchanges COMMODITY...

  20. 78 FR 9447 - Reporting and Recordkeeping Requirements; 8(a) Annual Update

    Science.gov (United States)

    2013-02-08

    ... ADMINISTRATION Reporting and Recordkeeping Requirements; 8(a) Annual Update AGENCY: Small Business Administration... INFORMATION: This information collection, 8(a) Annual Update, (Form 1450) is submitted by all small businesses participating in SBA's 8(a) Business Development Program (8(a) BD Program), to annually update and report to...

  1. 33 CFR Appendix B to Part 273 - Information Requirements for Aquatic Plant Control Program Reports

    Science.gov (United States)

    2010-07-01

    ... Aquatic Plant Control Program Reports B Appendix B to Part 273 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE AQUATIC PLANT CONTROL Pt. 273, App. B Appendix B to Part 273—Information Requirements for Aquatic Plant Control Program Reports 1. Location and...

  2. 40 CFR 80.1449 - What are the Production Outlook Report requirements?

    Science.gov (United States)

    2010-07-01

    ... planned or underway, information on all the following, as available: (i) Strategic planning. (ii) Planning... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What are the Production Outlook Report... Production Outlook Report requirements? (a) A registered renewable fuel producer or importer, for each of its...

  3. 20 CFR 645.240 - What are the reporting requirements for Welfare-to-Work programs?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What are the reporting requirements for.../tegltein.htm. The Internet reporting system for WtW grantees is accessible at http://www.etareports.doleta..., the recipient must develop accrual information through an analysis of the documentation on hand....

  4. 40 CFR 716.20 - Studies not subject to the reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Studies not subject to the reporting requirements. 716.20 Section 716.20 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT HEALTH AND SAFETY DATA REPORTING General Provisions § 716.20 Studies not subject to...

  5. 78 FR 62638 - Agency Recordkeeping/Reporting Requirements Under Emergency Review by the Office of Management...

    Science.gov (United States)

    2013-10-22

    ... HUMAN SERVICES Administration for Children and Families Agency Recordkeeping/Reporting Requirements Under Emergency Review by the Office of Management and Budget (OMB) Title: Low Income Home Energy... calling the Administration for Children and Families, Reports Clearance Officer, Robert Sargis at...

  6. Postmarketing safety reports for human drug and biological products; electronic submission requirements. Final rule.

    Science.gov (United States)

    2014-06-10

    The Food and Drug Administration (FDA or we) is amending its postmarketing safety reporting regulations for human drug and biological products to require that persons subject to mandatory reporting requirements submit safety reports in an electronic format that FDA can process, review, and archive. FDA is taking this action to improve the Agency's systems for collecting and analyzing postmarketing safety reports. The change will help the Agency to more rapidly review postmarketing safety reports, identify emerging safety problems, and disseminate safety information in support of FDA's public health mission. In addition, the amendments will be a key element in harmonizing FDA's postmarketing safety reporting regulations with international standards for the electronic submission of safety information.

  7. Two to five repeated measurements per patient reduced the required sample size considerably in a randomized clinical trial for patients with inflammatory rheumatic diseases

    Directory of Open Access Journals (Sweden)

    Smedslund Geir

    2013-02-01

    Full Text Available Abstract Background Patient reported outcomes are accepted as important outcome measures in rheumatology. The fluctuating symptoms in patients with rheumatic diseases have serious implications for sample size in clinical trials. We estimated the effects of measuring the outcome 1-5 times on the sample size required in a two-armed trial. Findings In a randomized controlled trial that evaluated the effects of a mindfulness-based group intervention for patients with inflammatory arthritis (n=71, the outcome variables Numerical Rating Scales (NRS (pain, fatigue, disease activity, self-care ability, and emotional wellbeing and General Health Questionnaire (GHQ-20 were measured five times before and after the intervention. For each variable we calculated the necessary sample sizes for obtaining 80% power (α=.05 for one up to five measurements. Two, three, and four measures reduced the required sample sizes by 15%, 21%, and 24%, respectively. With three (and five measures, the required sample size per group was reduced from 56 to 39 (32 for the GHQ-20, from 71 to 60 (55 for pain, 96 to 71 (73 for fatigue, 57 to 51 (48 for disease activity, 59 to 44 (45 for self-care, and 47 to 37 (33 for emotional wellbeing. Conclusions Measuring the outcomes five times rather than once reduced the necessary sample size by an average of 27%. When planning a study, researchers should carefully compare the advantages and disadvantages of increasing sample size versus employing three to five repeated measurements in order to obtain the required statistical power.

  8. 78 FR 48632 - Releasing Information; General Provisions; Accounting and Reporting Requirements; Reports of...

    Science.gov (United States)

    2013-08-09

    ... data. Additionally, the banks and associations will need to establish a data governance structure with... and uses of the information stored in the central data repository. This data governance structure... comments with relevant data or examples. A. Disclosing Reports of Examination and Other Non-Public...

  9. 78 FR 77557 - Releasing Information; General Provisions; Accounting and Reporting Requirements; Reports of...

    Science.gov (United States)

    2013-12-24

    ..., 618, and 621 RIN 3052-AC76 Releasing Information; General Provisions; Accounting and Reporting.... We will publish a notice of effective date in the Federal Register. Compliance Date: All provisions... the Act's provisions.\\2\\ Our regulations, including this final rule, are intended to ensure the...

  10. Fibroblast populated collagen matrix promotes islet survival and reduces the number of islets required for diabetes reversal.

    Science.gov (United States)

    Jalili, Reza B; Moeen Rezakhanlou, Alireza; Hosseini-Tabatabaei, Azadeh; Ao, Ziliang; Warnock, Garth L; Ghahary, Aziz

    2011-07-01

    Islet transplantation represents a viable treatment for type 1 diabetes. However, due to loss of substantial mass of islets early after transplantation, islets from two or more donors are required to achieve insulin independence. Islet-extracellular matrix disengagement, which occurs during islet isolation process, leads to subsequent islet cell apoptosis and is an important contributing factor to early islet loss. In this study, we developed a fibroblast populated collagen matrix (FPCM) as a novel scaffold to improve islet cell viability and function post-transplantation. FPCM was developed by embedding fibroblasts within type-I collagen and used as scaffold for islet grafts. Viability and insulin secretory function of islets embedded within FPCM was evaluated in vitro and in a syngeneic murine islet transplantation model. Islets embedded within acellular matrix or naked islets were used as control. Islet cell survival and function was markedly improved particularly after embedding within FPCM. The composite scaffold significantly promoted islet isograft survival and reduced the critical islet mass required for diabetes reversal by half (from 200 to 100 islets per recipient). Fibroblast embedded within FPCM produced fibronectin and growth factors and induced islet cell proliferation. No evidence of fibroblast over-growth within composite grafts was noticed. These results confirm that FPCM significantly promotes islet viability and functionality, enhances engraftment of islet grafts and decreases the critical islet mass needed to reverse hyperglycemia. This promising finding offers a new approach to reducing the number of islet donors per recipient and improving islet transplant outcome.

  11. Briquetting of self-reducing blendings of waste iron oxide mixtures. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Derungs, P.; Brouhon, J.M.; Harp, G. [ProfilARBED, Esch-sur Alzette (Luxembourg)

    2002-07-01

    The objectives of this project were to develop technologies to manufacture self-reducing briquettes out of waste iron oxides and to recycle them in an electric arc furnace or a cupola furnace. CRM has investigated and determined the optimal characteristics (binder, size, grain size, compositions and activator for the reduction reaction) for briquettes containing mixtures of mill scales, mill sludges, electric arc furnace (EAF) dust and coal as reduction agent. The goal of obtaining briquettes, in which iron oxides are totally reduced when these briquettes are loaded with the scrap into an electric arc furnace, was achieved. Trials at ProfilARBED have shown that it is possible to recycle mill and EAF by-products conditioned in self-reducing briquettes in an electric arc furnace without influence on the performance and on the environment. The iron content of the slag does not increase as the iron of the by-product is almost completely reduced. Zinc is completely removed and the concentration in the EAF dust increases. BFI has investigated the best recycling method for sludge and dust of the blast furnace and basic oxygen furnace, by laboratory testing and industrial trials in a cupola furnace. Self-reducing briquettes have been produced and reduced. The best conditions for achieving the required briquetting have been determined.

  12. Electroacupuncture-reduced sedative and analgesic requirements for diagnostic EUS: a prospective, randomized, double-blinded, sham-controlled study.

    Science.gov (United States)

    Bun Teoh, Anthony Yuen; Ning Chong, Charing Ching; Wa Leung, Wing; Cheong Chan, Simon Kin; Kit Tse, Yee; Wai Ng, Enders Kwok; San Lai, Paul Bo; Yuen Wu, Justin Che; Wong Lau, James Yun

    2017-07-24

    The role of electroacupuncture (EA) in reducing sedative and analgesic requirements during EUS is uncertain. The aim of the current study is to investigate the efficacy of EA in reducing procedure-related pain and discomfort during EUS. This was a double-blinded randomized controlled study conducted between March 2014 and July 2016. Consecutive patients who were scheduled for diagnostic EUS were recruited and randomized to receive electroacupuncture (EA) or sham-electroacupuncture (SA). The primary outcome was the dosage of propofol used. Other outcome measurements included pain scores, anxiety scores, satisfaction scores, patients' willingness to repeat the procedure, total procedure time, and adverse events. One hundred twenty-eight patients were recruited to the study. The patients that received EA had significantly fewer PCA requirements. The median (IQR range) number of demands for PCA (2 [1 - 5] vs 16.5 [8.5 - 33.8], P<0.001), the number of successful demands (2 [1 - 4] vs 9 [5.3 - 13], P<0.001), the total dose of propofol (0.15 [0.08 - 0.34] vs 0.77 [0.38 - 1.09], P<0.001) and alfentanil (0.38 [0.20 - 0.86] vs 1.92 [0.94 - 2.72], P<0.001) were all significantly less. Patients that received EA also had significantly less procedural pain scores and anxiety scores (P<0.001), higher satisfaction scores (P<0.001), and they are more willing to repeat the procedure (P<0.001). Both being in the SA group and the procedural time were significant predictors to increased PCA demands (P < 0.001 and P = 0.009 respectively). In conclusion, the use of EA reduced sedative and analgesic demands, improved patient experience, and was associated with low risk of adverse events during diagnostic EUS. Copyright © 2017 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  13. Dietary histidine requirement to reduce the risk and severity of cataracts is higher than the requirement for growth in Atlantic salmon smolts, independently of the dietary lipid source.

    Science.gov (United States)

    Remø, S C; Hevrøy, E M; Olsvik, P A; Fontanillas, R; Breck, O; Waagbø, R

    2014-05-28

    The present study was carried out to investigate whether the dietary histidine requirement to reduce cataract development is higher than that for growth in Atlantic salmon smolts (Salmo salar L.) after seawater transfer and whether dietary vegetable oils contribute to cataractogenesis. Duplicate groups of salmon smolts were fed ten experimental diets with either fish oil (FO) or a vegetable oil (VO) mix replacing 70 % FO and histidine at five target levels (10, 12, 14, 16 and 18 g His/kg diet) for 13 weeks after seawater transfer. The VO diet-fed fish exhibited somewhat inferior growth and feed intakes compared with the FO diet-fed fish, irrespective of the dietary histidine concentration. Both cataract prevalence and severity were negatively correlated with the dietary histidine concentration, while lens N-acetyl-histidine (NAH) concentrations were positively correlated with it. The fatty acid profiles of muscle, heart and lens reflected that of the dietary oils to a descending degree and did not affect the observed cataract development. Muscle, heart and brain histidine concentrations reflected dietary histidine concentrations, while the corresponding tissue imidazole (anserine, carnosine and NAH) concentrations appeared to saturate differently with time. The expression level of liver histidase was not affected by the dietary histidine concentration, while the liver antioxidant response was affected in the VO diet-fed fish on a transcriptional level. The lowest severity of cataracts could be achieved by feeding 13·4 g His/kg feed, independently of the dietary lipid source. However, the present study also suggests that the dietary histidine requirement to minimise the risk of cataract development is 14·4 g His/kg feed.

  14. Dry-grind processing using amylase corn and superior yeast to reduce the exogenous enzyme requirements in bioethanol production.

    Science.gov (United States)

    Kumar, Deepak; Singh, Vijay

    2016-01-01

    Conventional corn dry-grind ethanol production process requires exogenous alpha and glucoamylases enzymes to breakdown starch into glucose, which is fermented to ethanol by yeast. This study evaluates the potential use of new genetically engineered corn and yeast, which can eliminate or minimize the use of these external enzymes, improve the economics and process efficiencies, and simplify the process. An approach of in situ ethanol removal during fermentation was also investigated for its potential to improve the efficiency of high-solid fermentation, which can significantly reduce the downstream ethanol and co-product recovery cost. The fermentation of amylase corn (producing endogenous α-amylase) using conventional yeast and no addition of exogenous α-amylase resulted in ethanol concentration of 4.1 % higher compared to control treatment (conventional corn using exogenous α-amylase). Conventional corn processed with exogenous α-amylase and superior yeast (producing glucoamylase or GA) with no exogenous glucoamylase addition resulted in ethanol concentration similar to control treatment (conventional yeast with exogenous glucoamylase addition). Combination of amylase corn and superior yeast required only 25 % of recommended glucoamylase dose to complete fermentation and achieve ethanol concentration and yield similar to control treatment (conventional corn with exogenous α-amylase, conventional yeast with exogenous glucoamylase). Use of superior yeast with 50 % GA addition resulted in similar increases in yield for conventional or amylase corn of approximately 7 % compared to that of control treatment. Combination of amylase corn, superior yeast, and in situ ethanol removal resulted in a process that allowed complete fermentation of 40 % slurry solids with only 50 % of exogenous GA enzyme requirements and 64.6 % higher ethanol yield compared to that of conventional process. Use of amylase corn and superior yeast in the dry-grind processing industry

  15. Mindful attention reduces neural and self-reported cue-induced craving in smokers

    Science.gov (United States)

    Creswell, John David; Tabibnia, Golnaz; Julson, Erica; Kober, Hedy; Tindle, Hilary A.

    2013-01-01

    An emerging body of research suggests that mindfulness-based interventions may be beneficial for smoking cessation and the treatment of other addictive disorders. One way that mindfulness may facilitate smoking cessation is through the reduction of craving to smoking cues. The present work considers whether mindful attention can reduce self-reported and neural markers of cue-induced craving in treatment seeking smokers. Forty-seven (n = 47) meditation-naïve treatment-seeking smokers (12-h abstinent from smoking) viewed and made ratings of smoking and neutral images while undergoing functional magnetic resonance imaging (fMRI). Participants were trained and instructed to view these images passively or with mindful attention. Results indicated that mindful attention reduced self-reported craving to smoking images, and reduced neural activity in a craving-related region of subgenual anterior cingulate cortex (sgACC). Moreover, a psychophysiological interaction analysis revealed that mindful attention reduced functional connectivity between sgACC and other craving-related regions compared to passively viewing smoking images, suggesting that mindfulness may decouple craving neurocircuitry when viewing smoking cues. These results provide an initial indication that mindful attention may describe a ‘bottom-up’ attention to one’s present moment experience in ways that can help reduce subjective and neural reactivity to smoking cues in smokers. PMID:22114078

  16. FES Science Network Requirements - Report of the Fusion Energy Sciences Network Requirements Workshop Conducted March 13 and 14, 2008

    Energy Technology Data Exchange (ETDEWEB)

    Tierney, Brian; Dart, Eli; Tierney, Brian

    2008-07-10

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the U.S. Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States of America. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In March 2008, ESnet and the Fusion Energy Sciences (FES) Program Office of the DOE Office of Science organized a workshop to characterize the networking requirements of the science programs funded by the FES Program Office. Most sites that conduct data-intensive activities (the Tokamaks at GA and MIT, the supercomputer centers at NERSC and ORNL) show a need for on the order of 10 Gbps of network bandwidth for FES-related work within 5 years. PPPL reported a need for 8 times that (80 Gbps) in that time frame. Estimates for the 5-10 year time period are up to 160 Mbps for large simulations. Bandwidth requirements for ITER range from 10 to 80 Gbps. In terms of science process and collaboration structure, it is clear that the proposed Fusion Simulation Project (FSP) has the potential to significantly impact the data movement patterns and therefore the network requirements for U.S. fusion science. As the FSP is defined over the next two years, these changes will become clearer. Also, there is a clear and present unmet need for better network connectivity between U.S. FES sites and two Asian fusion experiments--the EAST Tokamak in China and the KSTAR Tokamak in South Korea. In addition to achieving its goal of collecting and characterizing the network requirements of the science endeavors funded by the FES Program Office, the workshop emphasized that there is a need for research into better ways of conducting remote

  17. Achieving minimum caseload requirements: an analysis of hospital quality control reports from 2004-2010.

    Science.gov (United States)

    de Cruppé, Werner; Malik, Marc; Geraedts, Max

    2014-08-18

    Legally mandated minimum hospital caseload requirements for certain invasive procedures, including pancreatectomy, esophagectomy, and some types of organ transplantation, have been in effect in Germany since 2004. The goal of such requirements is to improve patient care by ensuring that patients undergo certain procedures only in hospitals that have met the corresponding minimum caseload requirement. We used the case numbers published in legally mandated hospital quality control reports to determine whether the hospitals actually met the stipulated requirements. We performed a secondary analysis of data supplied by hospitals in their quality control reports for the years 2004, 2006, 2008, and 2010 with respect to six procedures that have a minimum caseload requirement: complex interventions on the esophagus and pancreas, total knee replacement, and hepatic, renal, and stem-cell transplantation. The total case numbers for these six different procedures rose from 22 064 (0.1% of all procedures) in 2004 to 170 801 (0.9% of all procedures) in 2010. From 2006 onward, procedures to which minimum caseload requirements apply have been carried out in half of all hospitals studied. These procedures account for 0.9% of all inpatient cases in Germany. The percentage of hospitals that continue to perform certain procedures despite not having met the minimum caseload requirement ranged from 5% to 45%, depending on the type of procedure, and the percentage of cases carried out in such hospitals ranged from 1% to 15%. These values remained nearly constant for each of the six minimum caseload requirements over the 4 reporting years for which data were examined. The establishment of minimum caseload requirements in Germany in 2004 did not lessen the number of cases performed in violation of these requirements over the period 2004 to 2010.

  18. Technical evaluation of RETS-required reports for Fort Calhoun Station Unit 1

    Energy Technology Data Exchange (ETDEWEB)

    Magleby, E.H.; Young, T.E.

    1985-06-24

    A review of the reports required by federal regulations and the plant-specific Radiological Effluent Technical Specifications (RETS) for operations conducted during 1983 was performed. The periodic reports reviewed for Fort Calhoun Station Unit 1 were two Semiannual Reports for Technical Specification 5.9.4. The principal review guidelines were the plant's specific RETS, NUREG-0133, ''Preparation of Radiological Effluent Technical Specifications for Nuclear Power Plants'', and NRC Guidance on the Review of the Process Control Programs. The Licensee's submitted reports were found to be reasonably complete and consistent with the review guidelines. 4 refs.

  19. Adjunctive treatment of decompression illness with a non-steroidal anti-inflammatory drug (tenoxicam) reduces compression requirement.

    Science.gov (United States)

    Bennett, M; Mitchell, S; Dominguez, A

    2003-01-01

    We report a randomized trial examining adjunctive administration of the NSAID, tenoxicam, to divers suffering with DCI. 180 subjects were graded for severity on admission and randomized according to a stratified random number schedule. Subjects were recompressed and treatment continued daily until symptom stabilization or complete resolution. Tenoxicam 20 mg or a placebo preparation was administered at the first air break during the initial recompression and continued daily for seven days. The subjects were assessed using a recovery status score at the completion of treatment and at 4-6 weeks. The proportion of patients with mild residual symptoms at discharge and final follow-up was not significantly different (discharge placebo 30% versus tenoxicam 37%, P=0.41; six weeks placebo 20% versus tenoxicam 17%, P=0.58). There was a significant reduction in the number of treatments required to achieve discharge (median treatments placebo 3, tenoxicam 2, P=0.01). 61% of patients in the tenoxicam group required less than 3 compressions, versus 40% in the placebo group (P=0.01, RRR 33 % [95%CI 9%-56%], NNT=5 [95%CI 3-18]). There was no evidence of increased complications of treatment in the tenoxicam group. When given this NSAID, patients with DCI require fewer hyperbaric oxygen (HBO2) sessions to achieve a standard clinical end-point and there is likely to be an associated cost saving.

  20. Cost and Performance Report Low Impact Technologies to Reduce Pollution from Storm Water Runoff SI-200405

    Science.gov (United States)

    2008-09-01

    and will likely require earthwork to remove the lids over the media bed. 44 5.2 Cost Analysis The economic analysis performed on the NRRC dual...pump system. Given these two scenarios, the economic evaluation was constructed and compared. 5.3.2 Cost Drivers The cost of the implementing a...report 7374 National Defense Center for Enviromental Exellence, 1999, Environmental Cost Analysis Methodology (CECAM) handbook, March 29, 1999

  1. TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

    DEFF Research Database (Denmark)

    Pedersen, Rune Troelsgaard; Kruse, Thomas; Nilsson, Jakob

    2015-01-01

    mitotic entry. In early mitosis, TopBP1 marks sites of and promotes unscheduled DNA synthesis. Moreover, TopBP1 is required for focus formation of the structure-selective nuclease and scaffold protein SLX4 in mitosis. Persistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise...... temporal depletion of TopBP1 just before mitotic entry induced formation of 53BP1 NBs in the next cell cycle, showing that TopBP1 acts to reduce transmission of DNA damage to G1 daughter cells. Based on these results, we propose that TopBP1 maintains genome integrity in mitosis by controlling chromatin...

  2. Using informatics-enabled quality improvement techniques to meet health record documentation requirements in radiology reports.

    Science.gov (United States)

    Prevedello, Luciano M; Farkas, Cameron; Dufault, Allen; Damiano, Maria; Doubilet, Peter; Khorasani, Ramin

    2013-08-01

    Medicare requires documented teaching physician involvement (attestation) in trainee-generated radiology reports. Automated attestation statement insertion in reports expedites the process but does not comply with requirements for active attestation. We evaluated an informatics-enabled quality improvement (QI) intervention to improve health record documentation requirements for active attestation. Institutional review board approval was not needed for this QI project performed in a 776-bed tertiary/quaternary teaching hospital. The intervention consisted of (1) policy requiring staff radiologists to actively attest to trainee-generated reports by personally activating a "macro" in the reporting system and (2) a semiautomated process to detect reports missing attestation; radiologists received daily e-mail reminders until the attestation statement was inserted. A random sample of 600 of 123,561 trainee-generated radiology reports created 17 months after the intervention (May 2011) was manually reviewed to determine attestation policy adherence. The number of attestation statements added in response to reminders throughout the entire study period was also evaluated. Trend analysis of the number of report addenda containing solely the attestation statement (proxy for missing initial attestation) was performed. Of 600 reports, 594 (99%) contained the attestation statement. Monthly attestations in response to email notifications decreased from 585 to 227 by the sixth month, a 2.6-fold reduction (P < .01). No significant trend was observed the following year, indicating a sustained effect. Informatics-enabled QI techniques resulted in 99% adherence to our teaching physician attestation policy with sustained results. Similar approaches may help improve adherence to other mandated performance measures in radiology reports. Copyright © 2013 AUR. Published by Elsevier Inc. All rights reserved.

  3. The PM/S module and the BIO/TSR requirements comparison report summary

    Energy Technology Data Exchange (ETDEWEB)

    PEERY, B.Q.

    1999-02-24

    This report summarizes the comparison between the Preventive Maintenance/Surveillance System (PM/S) database and the requirements identified in the Tank Waste Remediation Systems Basis for Interim Operation (BIO) (HNF-SD-WM-BIO-001); the Technical Safety Requirements (TSR's) (HNF-SD-WM-TSR-006); The Tank Farms Administrative Controls Manual, (HNF-IP-1266); and The TWRS Facility Safety Equipment List, (HNF-SD-WM-SEL-0404). Corrective actions identified are completed or in process.

  4. Traceability and communication of requirements in digital I and C systems development. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Sivertsen, T.; Fredriksen, Rune; Thunem, A.P.J. [Inst. for Energy Technology, Halden (Norway); Holmberg, J.E.; Valkonen, J.; Ventae, O. [VTT (Finland); Andersson, J.O. [Ringhals AB (Sweden)

    2005-10-01

    The overall objective of the TACO project has been to improve the knowledge on principles and best practices related to the traceability and communication of requirements in digital I and C systems development. On the basis of experiences in the Nordic countries, the project has aimed at identifying the best practices and most important criteria for ensuring effective communication in relation to requirements elicitation and analysis, understandability of requirements to all parties, and traceability of requirements through the different design phases. It is expected that the project will provide important input to the development of guidelines and establishment of recommended practices related to these activities. The report provides a summary of the project activities and deliverables, discusses possible application areas, and provides a link to its utilization in the project 'Management of Requirements in NPP Modernization Projects' (NKS-R-2005-47). In the preparation of the final report, a number of application areas have been identified where the TACO deliverables, first of all the TACO Shell and the TACO Traceability Model, can be utilized. The report aims at facilitating such utilization, by defining the context and main issues, explaining the main aspects of the deliverables, discussing the challenges experienced in the different application domains with respect requirements management, traceability and communication and how can the TACO results contribute to solving these challenges. (au)

  5. The reduced state of the plastoquinone pool is required for chloroplast-mediated stomatal closure in response to calcium stimulation.

    Science.gov (United States)

    Wang, Wen-Hua; He, En-Ming; Chen, Juan; Guo, Ying; Chen, Juan; Liu, Xiang; Zheng, Hai-Lei

    2016-04-01

    Besides their participation in photosynthesis, leaf chloroplasts function in plant responses to stimuli, yet how they direct stimulus-induced stomatal movement remains elusive. Here, we showed that over-reduction of the plastoquinone (PQ) pool by dibromothymoquinone (DBMIB) was closely associated with stomatal closure in plants which required chloroplastic H2O2 generation in the mesophyll. External application of H2 O2 reduced the PQ pool, whereas the cell-permeable reactive oxygen species (ROS) scavenger N-acetylcysteine (NAC) reversed the DBMIB-induced over-reduction of the PQ pool and stomatal closure. Mesophyll chloroplasts are key players of extracellular Ca(2+) (Ca(2+)o)-induced stomatal closure, but when treated with either 3-(3',4'-dichlorophenyl)-1,1-dimethylurea (DCMU) or NAC they failed to facilitate Ca(2+)o-induced stomatal closure due to the inhibition of chloroplastic H2 O2 synthesis in mesophyll. Similarly, the Arabidopsis electron transfer chain-related mutants npq4-1, stn7 and cas-1 exhibited diverse responses to Ca(2+)o or DBMIB. Transcriptome analysis also demonstrated that the PQ pool signaling pathway shared common responsive genes with the H2 O2 signaling pathway. These results implicated a mechanism for chloroplast-mediated stomatal closure involving the generation of mesophyll chloroplastic H2O2 based on the reduced state of the PQ pool, which is calcium-sensing receptor (CAS) and LHCII phosphorylation dependent.

  6. 20 CFR 404.1519n - Informing the medical source of examination scheduling, report content, and signature requirements.

    Science.gov (United States)

    2010-04-01

    ... scheduling, report content, and signature requirements. 404.1519n Section 404.1519n Employees' Benefits... medical source of examination scheduling, report content, and signature requirements. The medical sources... report containing all of the elements in paragraph (c). (e) Signature requirements. All...

  7. 15 CFR 745.2 - End-Use Certificate reporting requirements under the Chemical Weapons Convention.

    Science.gov (United States)

    2010-01-01

    ... foreign affairs or any other agency or department designated by the importing government for this purpose... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false End-Use Certificate reporting requirements under the Chemical Weapons Convention. 745.2 Section 745.2 Commerce and Foreign Trade Regulations...

  8. 34 CFR 682.414 - Records, reports, and inspection requirements for guaranty agency programs.

    Science.gov (United States)

    2010-07-01

    ... concerning the status of the agency's reserve fund and the operation of the agency's loan guarantee program... 34 Education 3 2010-07-01 2010-07-01 false Records, reports, and inspection requirements for... LOAN (FFEL) PROGRAM Administration of the Federal Family Education Loan Programs by a Guaranty Agency...

  9. 15 CFR 711.1 - Overviews of declaration, reporting, and advance notification requirements.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Overviews of declaration, reporting, and advance notification requirements. 711.1 Section 711.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF...

  10. 25 CFR 1000.365 - What are the requirements of the review team report?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What are the requirements of the review team report? 1000.365 Section 1000.365 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Trust Evaluation Review Annual Trust Evaluations § 1000.365 What are...

  11. 40 CFR Table 14 to Subpart Wwww of... - Requirements for Reports

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Requirements for Reports 14 Table 14 to Subpart WWWW of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... to this subpart that apply to you. If there were no periods during which the CMS, including CEMS,...

  12. 40 CFR Table 6 to Subpart Nnnnn of... - Requirements for Reports

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 14 2010-07-01 2010-07-01 false Requirements for Reports 6 Table 6 to Subpart NNNNN of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR...-control in accordance with the monitoring plan There were no periods during which the CMS were...

  13. 76 FR 48742 - Kiwifruit Grown in California; Change in Reporting Requirements and New Information Collection

    Science.gov (United States)

    2011-08-09

    ... definition. In addition, based on kiwifruit production and price information, as well as the total number of...; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing Service 7 CFR Part 920 Kiwifruit Grown in California; Change in Reporting Requirements and New Information Collection AGENCY: Agricultural Marketing Service,...

  14. 42 CFR 413.198 - Recordkeeping and cost reporting requirements for outpatient maintenance dialysis.

    Science.gov (United States)

    2010-10-01

    ... outpatient maintenance dialysis. 413.198 Section 413.198 Public Health CENTERS FOR MEDICARE & MEDICAID... § 413.198 Recordkeeping and cost reporting requirements for outpatient maintenance dialysis. (a) Purpose... will enable CMS to determine the costs incurred in furnishing outpatient maintenance dialysis...

  15. 14 CFR 417.17 - Launch reporting requirements and launch specific updates.

    Science.gov (United States)

    2010-01-01

    ... flight safety analysis products, using previously approved methodologies, for each launch no later than...) May not change an analysis product within the final 30 days before flight unless the launch operator... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Launch reporting requirements and...

  16. U.S. EPA requires Cupertino cement company to report toxic chemicals, commit to environmental projects

    Science.gov (United States)

    SAN FRANCISCO - The U.S. Environmental Protection Agency announced a settlement with Lehigh Southwest Cement Company for failing to properly report releases of toxic chemicals at its Cupertino, Calif. plant. The company is required to pay a $47,600

  17. 76 FR 8399 - Reports, Forms and Record Keeping Requirements; Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2011-02-14

    ... National Highway Traffic Safety Administration Reports, Forms and Record Keeping Requirements; Agency...., Washington, DC 20503, Attention NHTSA Desk Officer. Comments are invited on: Whether the proposed collection..., including the use of automated collection techniques or other forms of information technology. A comment...

  18. 78 FR 36633 - Reports, Forms and Record Keeping Requirements, Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2013-06-18

    ... TRANSPORTATION National Highway Traffic Safety Administration Reports, Forms and Record Keeping Requirements... Affairs, Office of Management and Budget, 725--17th Street NW., Washington, DC 20503, Attention NHTSA Desk... automated collection techniques or other forms of information technology. A comment to OMB is most...

  19. 75 FR 19453 - Reports, Forms and Record Keeping Requirements; Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2010-04-14

    ... National Highway Traffic Safety Administration Reports, Forms and Record Keeping Requirements; Agency... Officer, Office of Management and Budget, Office of Information and Regulatory Affairs, Attention: by fax... automated collection techniques or other forms of information technology. A Comment to OMB is most...

  20. 75 FR 36150 - Reports, Forms and Record Keeping Requirements; Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2010-06-24

    ... National Highway Traffic Safety Administration Reports, Forms and Record Keeping Requirements; Agency... 17th Street, NW., Washington, DC 20503, Attention NHTSA Desk Officer. Comments are invited on: Whether... information on respondents, including the use of automated collection techniques or other forms of...

  1. 76 FR 35266 - Reports, Forms and Record Keeping Requirements; Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2011-06-16

    ... National Highway Traffic Safety Administration Reports, Forms and Record Keeping Requirements; Agency... Management and Budget, 725 17th Street, NW., Washington, DC 20503, Attention NHTSA Desk Officer. Comments are... collection of information on respondents, including the use of automated collection techniques or other...

  2. 76 FR 76218 - Reports, Forms and Record Keeping Requirements; Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2011-12-06

    ... National Highway Traffic Safety Administration Reports, Forms and Record Keeping Requirements; Agency... respondents, including the use of automated collection techniques or other forms of information technology. A... Budget, 725-17th Street NW., Washington, DC 20503, Attention NHTSA Desk Officer. Issued in Washington,...

  3. 15 CFR 30.38 - Exemption from the requirements for reporting complete commodity information.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Exemption from the requirements for reporting complete commodity information. 30.38 Section 30.38 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN...

  4. 75 FR 29404 - Contract Reporting Requirements of Intrastate Natural Gas Companies

    Science.gov (United States)

    2010-05-26

    ...: In this Final Rule, the Commission revises the contract reporting requirements for those natural gas pipelines that fall under the Commission's jurisdiction pursuant to section 311 of the Natural Gas Policy Act or section 1(c) of the Natural Gas Act. The Final Rule revises Sec. 284.126(b) and replaces...

  5. 25 CFR 36.120 - What type of reporting is required to ensure accountability?

    Science.gov (United States)

    2010-04-01

    ... accountability? 36.120 Section 36.120 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION... SITUATIONS Homeliving Programs Waivers and Accountability § 36.120 What type of reporting is required to ensure accountability? The homeliving program must provide to the appropriate local school board...

  6. 17 CFR 1.40 - Crop, market information letters, reports; copies required.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Crop, market information letters, reports; copies required. 1.40 Section 1.40 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Miscellaneous § 1.40 Crop, market...

  7. A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia.

    Science.gov (United States)

    2016-04-01

    The above article from European Journal of Neuroscience, published online on 5 March 2013 in Wiley Online Library (http://onlinelibrary.wiley.com/doi/10.1111/ejn.12162/full), has been retracted by agreement between the Editors-in-Chief, Paul Bolam and John Foxe, the authors and John Wiley & Sons Ltd. The retraction has been agreed as Dr Phillip Barber has informed the publisher that he had seen neither the original data nor any version of the manuscript, and had not been involved in the work reported. A subsequent Institutional investigation found evidence of misconduct on the part of the submitting author. Reference Wang, L.-M., Wang, Y.-J., Cui, M., Luo, W.-J., Wang, X.-J., Barber, P.A. & Chen, Z.-Y. (2013) A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia.

  8. Pain reported during prolonged standing is associated with reduced anticipatory postural adjustments of the deep abdominals.

    Science.gov (United States)

    Marshall, Paul W M; Romero, Rick; Brooks, Cristy

    2014-11-01

    Within the context of low back pain, the measurement of deep abdominal anticipatory postural adjustments (APAs) during rapid limb movement has received much interest. There is dispute about the association between APAs and back pain. Moreover, there is limited evidence examining compensatory postural adjustments (CPAs) in back pain. This study examined the relationship between APAs and CPAs with pain reported in the low back during 2 h of prolonged standing. Twenty-six participants with no history of severe back pain performed 2-h prolonged standing. APAs and CPAs of the deep abdominal muscles (transverse abdominis/internal obliques) were measured by surface electromyography during rapid shoulder flexion and extension. APAs and CPAs measured pre-standing revealed symmetrical anticipatory activity, but an asymmetry between the different sides of the abdominal wall for CPAs. APAs and CPAs measured pre-standing were not associated with pain reported during standing. For the whole group, APA amplitudes were reduced post-standing during shoulder flexion (p = 0.005). Pain reported during standing was associated with the changes in APA amplitudes post-standing (rs = 0.43, p = 0.002). These findings support previous research using hypertonic saline injections to induce back pain that showed reduced APA amplitudes, and extends findings to suggest pain does not effect compensatory postural adjustments.

  9. Terminal ballistics of a reduced-mass penetrator. Final report, January 1990--December 1995

    Energy Technology Data Exchange (ETDEWEB)

    Silsby, G.F.

    1996-07-01

    This report presents the results of an experimental program to examine the performance of a reduced-mass concept penetrator impacting semi-infinite rolled homogeneous armor (RHA) at normal incidence. The reduced-mass penetrator used in this program is a solid tungsten alloy rod with eight holes drilled parallel to its axis, equally spaced on a circle, with axes parallel to the rod axis. Its performance was contrasted with baseline data for length-to- diameter ratios (L/D) 4 and 5 solid tungsten alloy penetrators. Striking velocity was nominally 1.6 km/s. A determined effort to reduce the scatter in the data by analysis of collateral data from the US Army Research Laboratory (ARL) and literature sources suggested only a rather weak influence of L/D on penetration even at L/Ds approaching 1 and provided a tentative relationship to remove the influence of target lateral edge effects. It tightened up the holed-out rod data enough to be able to conclude with a moderate degree of certainty that there was no improvement in penetration as suggested by a simplistic density law model. A companion work by Kimsey of ARL examines the performance of this novel penetrator concept computationally, using the Eulerian code CTH. His work explains the possible causes of reduced performance suggested by analysis by Zook and Frank of ARL, though with some relative improvement in performance at higher velocities.

  10. Evaluation of Reports Required by the Statutes for Distribution of Monetary Donations and Allowances

    Directory of Open Access Journals (Sweden)

    Harun Tugcu

    2007-12-01

    Full Text Available Physicians have to write reports in accordance with the relevant laws, statutes and regulations when requested by the administrations for distribution of monetary donations and allowances. The Statutes for Distribution of Monetary Donations and Allowances show the conditions requiring monetary support, the people who need monetary donations and the types of making monetary donations in cases of disabilities and injuries. We retrospectively reviewed the reports written in accordance with the Statutes for Distribution of Monetary Donations and Allowances in the Department of Forensic Medicine of Gulhane Military Medical Academy between 1st January 2005 and 31st December 2006. There were 87 reports written in accordance with the Statutes for Distribution of Monetary Donations and Allowances. The mean age of the cases was 25.93 ±5.8 years (20-43 years. The most frequent condition requiring monetary support was gun shot wounds (42.6%. The most frequent location of the wounds was the head (31% and there was an increase in the duration of work leave caused by disabilities (p<0.05. The aim of this study was to determine problems which physicians face when they write reports required by the Statutes for Distribution of Monetary Donations and Allowances and to underline the points concerning writing those reports based on the relevant laws. [TAF Prev Med Bull. 2007; 6(6: 475-478

  11. Evaluation of Reports Required by the Statutes for Distribution of Monetary Donations and Allowances

    Directory of Open Access Journals (Sweden)

    Harun Tugcu

    2007-12-01

    Full Text Available Physicians have to write reports in accordance with the relevant laws, statutes and regulations when requested by the administrations for distribution of monetary donations and allowances. The Statutes for Distribution of Monetary Donations and Allowances show the conditions requiring monetary support, the people who need monetary donations and the types of making monetary donations in cases of disabilities and injuries. We retrospectively reviewed the reports written in accordance with the Statutes for Distribution of Monetary Donations and Allowances in the Department of Forensic Medicine of Gulhane Military Medical Academy between 1st January 2005 and 31st December 2006. There were 87 reports written in accordance with the Statutes for Distribution of Monetary Donations and Allowances. The mean age of the cases was 25.93 ±5.8 years (20-43 years. The most frequent condition requiring monetary support was gun shot wounds (42.6%. The most frequent location of the wounds was the head (31% and there was an increase in the duration of work leave caused by disabilities (p<0.05. The aim of this study was to determine problems which physicians face when they write reports required by the Statutes for Distribution of Monetary Donations and Allowances and to underline the points concerning writing those reports based on the relevant laws. [TAF Prev Med Bull 2007; 6(6.000: 475-478

  12. Use of remifentanil to reduce propofol injection pain and the required propofol dose in upper digestive tract endoscopy diagnostic tests

    Directory of Open Access Journals (Sweden)

    Gustavo Nadal Uliana

    2015-12-01

    Full Text Available BACKGROUND AND OBJECTIVES: The introduction of propofol (2,6-diisopropylphenol as a sedative agent has transformed the area of sedation for endoscopic procedures. However, a major drawback of sedation with the use of propofol is its high incidence of injection pain. The most widely used technique in reducing propofol injection pain is through the association of other drugs. The aim of this study was to evaluate the effect of remifentanil-propofol combination on the incidence of propofol injection pain and its influence on the total dose of propofol required for sedation in upper digestive tract endoscopy (UDE diagnostic tests. METHOD: One hundred and five patients undergoing upper digestive tract endoscopy were evaluated and randomly divided into 3 groups of 35 patients each. The Control Group received propofol alone; Study-group 1 received remifentanil at a fixed dose of 0.2 mg/kg combined with propofol; Study-group 2 received remifentanil at a fixed dose of 0.3 mg/kg combined with propofol. The incidence of propofol injection pain and the total dose of propofol required for the test were evaluated. The sample was very similar regarding age, weight, height, sex, and physical status. Statistical analysis was performed according to the nature of the evaluated data. Student'st-test was used to compare the mean of age, weight, height (cm, and dose (mg/kg variables between groups. The χ2 test was used to compare sex, physical status, and propofol injection pain between groups. The significance level was a < 0.05. RESULTS: There was significant statistical difference between the study groups and the control group regarding the parameters of propofol injection pain and total dose of propofol (mg/kg used. However, there were no statistical differences between the two study groups for these parameters. CONCLUSION: We conclude that the use of remifentanil at doses of 0.2 mg/kg and 0.3 mg/kg was effective for reducing both the propofol injection pain and

  13. Predictive Modeling of Massive Transfusion Requirements During Liver Transplantation and Its Potential to Reduce Utilization of Blood Bank Resources.

    Science.gov (United States)

    Pustavoitau, Aliaksei; Lesley, Maggie; Ariyo, Promise; Latif, Asad; Villamayor, April J; Frank, Steven M; Rizkalla, Nicole; Merritt, William; Cameron, Andrew; Dagher, Nabil; Philosophe, Benjamin; Gurakar, Ahmet; Gottschalk, Allan

    2017-05-01

    Patients undergoing liver transplantation frequently but inconsistently require massive blood transfusion. The ability to predict massive transfusion (MT) could reduce the impact on blood bank resources through customization of the blood order schedule. Current predictive models of MT for blood product utilization during liver transplantation are not generally applicable to individual institutions owing to variability in patient population, intraoperative management, and definitions of MT. Moreover, existing models may be limited by not incorporating cirrhosis stage or thromboelastography (TEG) parameters. This retrospective cohort study included all patients who underwent deceased-donor liver transplantation at the Johns Hopkins Hospital between 2010 and 2014. We defined MT as intraoperative transfusion of > 10 units of packed red blood cells (pRBCs) and developed a multivariable predictive model of MT that incorporated cirrhosis stage and TEG parameters. The accuracy of the model was assessed with the goodness-of-fit test, receiver operating characteristic analysis, and bootstrap resampling. The distribution of correct patient classification was then determined as we varied the model threshold for classifying MT. Finally, the potential impact of these predictions on blood bank resources was examined. Two hundred three patients were included in the study. Sixty (29.6%) patients met the definition for MT and received a median (interquartile range) of 19.0 (14.0-27.0) pRBC units intraoperatively compared with 4.0 units (1.0-6.0) for those who did not satisfy the criterion for MT. The multivariable model for predicting MT included Model for End-stage Liver Disease score, whether simultaneous liver and kidney transplant was performed, cirrhosis stage, hemoglobin concentration, platelet concentration, and TEG R interval and angle. This model demonstrated good calibration (Hosmer-Lemeshow goodness-of-fit test P = .45) and good discrimination (c statistic: 0.835; 95

  14. Report of IEA workshop on reduced activation ferritic/martensitic steels

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    IEA Workshop on Reduced Activation Ferritic/Martensitic Steels under implementing agreement for program of research and development on fusion materials was held at Tokyo Yayoi Kaikan and JAERI headquarter on November 2-3, 2000. The objective of this workshop was a review of the fusion material development programs, the progress of the collaboration and the irradiation effects studies on RAF/M steels in the collaborating parties (Europe, Russia the United States, and Japan). Moreover, the development of plans for future collaboration was discussed. The present report contains viewgraphs presented at the workshop. (author)

  15. Mindful attention reduces neural and self-reported cue-induced craving in smokers

    OpenAIRE

    Westbrook, Cecilia; Creswell, John David; Tabibnia, Golnaz; Julson, Erica; Kober, Hedy; Tindle, Hilary A.

    2011-01-01

    An emerging body of research suggests that mindfulness-based interventions may be beneficial for smoking cessation and the treatment of other addictive disorders. One way that mindfulness may facilitate smoking cessation is through the reduction of craving to smoking cues. The present work considers whether mindful attention can reduce self-reported and neural markers of cue-induced craving in treatment seeking smokers. Forty-seven (n = 47) meditation-naïve treatment-seeking smokers (12-h abs...

  16. Pertuzumab, trastuzumab and docetaxel reduced the recurrence of brain metastasis from breast cancer: a case report.

    Science.gov (United States)

    Senda, Noriko; Yamaguchi, Ayane; Nishimura, Hideaki; Shiozaki, Toshiki; Tsuyuki, Shigeru

    2016-03-01

    The CLEOPATRA trial reported the survival benefit of pertuzumab with trastuzumab plus docetaxel in HER2-positive metastatic breast cancer patients. However, there are a few case reports concerning the effects of a pertuzumab-containing regimen on brain metastases. A 55-year-old woman, who underwent curative surgery for breast cancer after neoadjuvant chemotherapy 5 years previously, developed repeated solitary brain metastasis in her right occipital lobe. Whole brain radiation therapy, stereotactic radiosurgery and 3 times of surgical resection were performed. Lapatinib and capecitabine plus tamoxifen were administered. The metastasis recurred in the stump of the previous surgery. Pertuzumab with trastuzumab plus docetaxel was initiated as second-line chemotherapy. A complete response of the brain metastasis was achieved, which persisted for 5 months. Pertuzumab with trastuzumab plus docetaxel was effective in reducing the brain metastases from breast cancer. Further studies are warranted to confirm the effect of this regimen on brain metastases.

  17. Reduced anesthetic requirements, diminished brain plasma membrane Ca(2+)-ATPase pumping, and enhanced brain synaptic plasma membrane phospholipid methylation in diabetic rats: effects of insulin.

    Science.gov (United States)

    Janicki, P K; Horn, J L; Singh, G; Janson, V E; Franks, W T; Franks, J J

    1995-01-01

    We have recently reported that streptozocin (STZ)-induced diabetes in rats was associated with i) reduced Ca2+ pumping by rat brain synaptic plasma membrane Ca(2+)-ATPase (PMCA) and ii) a substantial reduction in the partial pressures of halothane and xenon required to prevent movement in response to stimulation (minimum effective dose or MED). MED for both agents correlated well with the degree of hemoglobin glycation and with PMCA activity. We now report that MEDs for isoflurane, enflurane, and desflurane were also substantially reduced in STZ-diabetic rats, compared with placebo-injected controls. In addition, we examined the effect of insulin treatment, begun 2 weeks after induction of diabetes and continued for 3 more weeks, on isoflurane MED and on brain synaptic PMCA and phospholipid-N-methyltransferase I (PLMT I), another enzyme altered by inhalation anesthetics (IA). Partial treatment of diabetes, as indicated by decreased glycated hemoglobin (GHb) compared to untreated diabetic rats, was associated with an isoflurane MED of 1.05 vol%, intermediate between a control mean of 1.57 vol% and an untreated diabetic mean of 0.82 vol% (p SPM from diabetic rats did not differ from control values, but PMCA pumping in SPM from the D-M was reduced to about 85% of control levels. Good correlation (r = 0.89, p < 0.01) was found between isoflurane MED and GHb in all treatment groups. These findings provide further evidence for an important role for PMCA in IA action. They also suggest that anesthetic effects on the calcium pump at specific anatomic sites may be of major importance in producing anesthesia.

  18. TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells.

    Science.gov (United States)

    Pedersen, Rune Troelsgaard; Kruse, Thomas; Nilsson, Jakob; Oestergaard, Vibe H; Lisby, Michael

    2015-08-17

    Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Replication stress delays replication into G2/M, which in turn impairs proper chromosome segregation and inflicts DNA damage on the daughter cells. Here we show that TopBP1 forms foci upon mitotic entry. In early mitosis, TopBP1 marks sites of and promotes unscheduled DNA synthesis. Moreover, TopBP1 is required for focus formation of the structure-selective nuclease and scaffold protein SLX4 in mitosis. Persistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise temporal depletion of TopBP1 just before mitotic entry induced formation of 53BP1 NBs in the next cell cycle, showing that TopBP1 acts to reduce transmission of DNA damage to G1 daughter cells. Based on these results, we propose that TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 and by facilitating unscheduled DNA synthesis.

  19. TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells

    Science.gov (United States)

    Pedersen, Rune Troelsgaard; Kruse, Thomas; Nilsson, Jakob

    2015-01-01

    Genome integrity is critically dependent on timely DNA replication and accurate chromosome segregation. Replication stress delays replication into G2/M, which in turn impairs proper chromosome segregation and inflicts DNA damage on the daughter cells. Here we show that TopBP1 forms foci upon mitotic entry. In early mitosis, TopBP1 marks sites of and promotes unscheduled DNA synthesis. Moreover, TopBP1 is required for focus formation of the structure-selective nuclease and scaffold protein SLX4 in mitosis. Persistent TopBP1 foci transition into 53BP1 nuclear bodies (NBs) in G1 and precise temporal depletion of TopBP1 just before mitotic entry induced formation of 53BP1 NBs in the next cell cycle, showing that TopBP1 acts to reduce transmission of DNA damage to G1 daughter cells. Based on these results, we propose that TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 and by facilitating unscheduled DNA synthesis. PMID:26283799

  20. Using database reports to reduce workplace violence: Perceptions of hospital stakeholders.

    Science.gov (United States)

    Arnetz, Judith E; Hamblin, Lydia; Ager, Joel; Aranyos, Deanna; Essenmacher, Lynnette; Upfal, Mark J; Luborsky, Mark

    2015-01-01

    Documented incidents of violence provide the foundation for any workplace violence prevention program. However, no published research to date has examined stakeholders' preferences for workplace violence data reports in healthcare settings. If relevant data are not readily available and effectively summarized and presented, the likelihood is low that they will be utilized by stakeholders in targeted efforts to reduce violence. To discover and describe hospital system stakeholders' perceptions of database-generated workplace violence data reports. Eight hospital system stakeholders representing Human Resources, Security, Occupational Health Services, Quality and Safety, and Labor in a large, metropolitan hospital system. The hospital system utilizes a central database for reporting adverse workplace events, including incidents of violence. A focus group was conducted to identify stakeholders' preferences and specifications for standardized, computerized reports of workplace violence data to be generated by the central database. The discussion was audio-taped, transcribed verbatim, processed as text, and analyzed using stepwise content analysis. Five distinct themes emerged from participant responses: Concerns, Etiology, Customization, Use, and Outcomes. In general, stakeholders wanted data reports to provide ``the big picture,'' i.e., rates of occurrence; reasons for and details regarding incident occurrence; consequences for the individual employee and/or the workplace; and organizational efforts that were employed to deal with the incident. Exploring stakeholder views regarding workplace violence summary reports provided concrete information on the preferred content, format, and use of workplace violence data. Participants desired both epidemiological and incident-specific data in order to better understand and work to prevent the workplace violence occurring in their hospital system.

  1. IFMIF (International Fusion Materials Irradiation Facility) conceptual design activity reduced cost report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-02-01

    This report describes the results of a preliminary reevaluation of the design and cost of the International Fusion Materials Irradiation Facility (IFMIF) Project in response to the request from the 28th FPCC meeting in January 1999. Two major ideas have been considered: 1) reduction of the total construction cost through elimination of the previously planned facility upgrade and 2) a facility deployment in 3 stages with capabilities for limited experiments in the first stage. As a result, the size and complexity of the facility could be significantly reduced, leading to substantial cost savings. In addition to these two ideas, this study also included a critical review of the original CDA specification with the objective of elimination of nonessential items. For example, the number of lithium targets was reduced from two to one. As a result of these changes in addition to the elimination of the upgrade, the total cost estimate was very substantially reduced from 797.2 MICF to 487.8 MICF, where 1 MICF = 1 Million of the IFMIF Conversion Units (approximately $1M US January, 1996). (author)

  2. 75 FR 17919 - Submission for OMB Review; American Recovery and Reinvestment Act-One-time Reporting Requirements...

    Science.gov (United States)

    2010-04-08

    ...; American Recovery and Reinvestment Act--One-time Reporting Requirements for Prime Contractors AGENCY... collection requirement concerning the American Recovery and Reinvestment Act--One-time Reporting Requirements... information on those who are to respond, through the use of appropriate technological collection techniques...

  3. 40 CFR 270.105 - Who must sign the application and any required reports for a RAP?

    Science.gov (United States)

    2010-07-01

    ... required reports for a RAP? 270.105 Section 270.105 Protection of Environment ENVIRONMENTAL PROTECTION... PROGRAM Remedial Action Plans (RAPs) Applying for A Rap § 270.105 Who must sign the application and any required reports for a RAP? Both the owner and the operator must sign the RAP application and any required...

  4. The role of technology in reducing health care costs. Final project report

    Energy Technology Data Exchange (ETDEWEB)

    Sill, A.E.; Warren, S.; Dillinger, J.D.; Cloer, B.K.

    1997-08-01

    Sandia National Laboratories applied a systems approach to identifying innovative biomedical technologies with the potential to reduce U.S. health care delivery costs while maintaining care quality. This study was conducted by implementing both top-down and bottom-up strategies. The top-down approach used prosperity gaming methodology to identify future health care delivery needs. This effort provided roadmaps for the development and integration of technology to meet perceived care delivery requirements. The bottom-up approach identified and ranked interventional therapies employed in existing care delivery systems for a host of health-related conditions. Economic analysis formed the basis for development of care pathway interaction models for two of the most pervasive, chronic disease/disability conditions: coronary artery disease (CAD) and benign prostatic hypertrophy (BPH). Societal cost-benefit relationships based on these analyses were used to evaluate the effect of emerging technology in these treatment areas. 17 figs., 48 tabs.

  5. Report on the Depth Requirements for a Massive Detector at Homestake

    CERN Document Server

    Bernstein, Adam; Blucher, Edward; Cline, David B; Diwan, Milind V; Fleming, Bonnie; Hladysz, Zbigniew J; Kadel, Richard; Kearns, Edward; Klein, Joshua; Lande, Kenneth; Lanni, Francesco; Lissauer, David; Marks, Steve; McKeown, Robert; Morse, William; Rameika, Regina; Roggenthen, William M; Scholberg, Kate; Smy, Michael; Sobel, Henry; Stewart, James; Sullivan, Gregory; Svoboda, Robert; Vagins, Mark; Viren, Brett; Walter, Christopher; Zwaska, Robert

    2009-01-01

    This report provides the technical justification for locating a large detector underground in a US based Deep Underground Science and Engineering Laboratory. A large detector with a fiducial mass in the mega-ton scale will most likely be a multipurpose facility. The main physics justification for such a device is detection of accelerator generated neutrinos, nucleon decay, and natural sources of neutrinos such as solar, atmospheric and supernova neutrinos. In addition to the physics justification there are practical issues regarding the existing infrastructure at Homestake, and the stress characteristics of the Homestake rock formations. The depth requirements associated with the various physics processes are reported for water Cherenkov and liquid argon detector technologies. While some of these physics processes can be adequately studied at shallower depths, none of them require a depth greater than 4300 mwe which corresponds to the 4850 ft level at Homestake. It is very important to note that the scale of ...

  6. Postural correction reduces hip pain in adult with acetabular dysplasia: A case report.

    Science.gov (United States)

    Lewis, Cara L; Khuu, Anne; Marinko, Lee N

    2015-06-01

    Developmental dysplasia of the hip is often diagnosed in infancy, but less severe cases of acetabular dysplasia are being detected in young active adults. The purpose of this case report is to present a non-surgical intervention for a 31-year-old female with mild acetabular dysplasia and an anterior acetabular labral tear. The patient presented with right anterior hip and groin pain, and she stood with the trunk swayed posterior to the pelvis (swayback posture). The hip pain was reproduced with the anterior impingement test. During gait, the patient maintained the swayback posture and reported 6/10 hip pain. Following correction of the patient's posture, the patient's pain rating was reduced to a 2/10 while walking. The patient was instructed to maintain the improved posture. At the 1 year follow-up, she demonstrated significantly improved posture in standing and walking. She had returned to recreational running and was generally pain-free. The patient demonstrated improvement on self-reported questionnaires for pain, function, and activity. These findings suggest that alteration of posture can have an immediate and lasting effect on hip pain in persons with structural abnormality and labral pathology. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. 41 CFR 304-3.17 - If I am required to file a confidential or public financial disclosure report, must I report...

    Science.gov (United States)

    2010-07-01

    ... a confidential or public financial disclosure report, must I report travel payments I receive from a....17 If I am required to file a confidential or public financial disclosure report, must I report... Ethics in Government Act of 1978). Note: The confidential financial disclosure report is OGE Form 450...

  8. ROLE OF TRANEXAMIC ACID IN REDUCING POSTOPERATIVE BLOOD LOSS AND TRANSFUSION REQUIREMENT IN PATIENTS UNDERGOING LOWER LIMB ORTHOPEDIC SURGERIES

    Directory of Open Access Journals (Sweden)

    Yashwant

    2014-09-01

    Full Text Available AIM: Aim of our study to assess the effects of tranexamic acid (TA in patients undergoing lower limb orthopedic surgeries. OBJECTIVE: Assess the effects of tranexamic acid on prevention of bleeding and requirement of blood transfusion after major lower limb orthopedic surgeries. MATERIAL AND METHOD: 90 patients ASA grade I & II undergoing elective surgery for femoral fracture like open reduction internal fixation, hemiarthroplasty, total hip replacement (THR under anaesthesia were taken. Patients were classified randomly into 2 groups (forty five patients in each group. Group T: Patients received inj. TA 10 mg/kg body weight. Group P: Patients received normal saline 1 ml/kg body weight 15 min before surgery. Postoperative hemoglobin concentration (on day 0 and day 2 and volume of blood in the drain were measured. The number of units of packed red cells transfused during the hospital stay was recorded and any thromboembolic and other complications were documented. RESULT: Analysis revealed that there were no significant differences between the patients with respect to age, sex, duration and type of surgery and preoperative mean hemoglobin concentration. Neither heart rate nor MABP has statistically significant difference or results (P>0.05. The drains were removed in the evening of the first postoperative day. Mean volume of blood in the drain compared to placebo group showing a highly significant reduction in postoperative blood loss (P=0.01. Mean fall in hemoglobin at day 0 and day 2 was 2 less in the study group as compared to the placebo that has P value 0.01 making it significant finding. CONCLUSION: the present paired study demonstrated that the administration of TA given preoperatively reduces the blood loss in the first 24 h by a highly significant degree as well it causes a significant reduction in postoperative anemia and need for transfusion among these patients.

  9. Reduced chronotropic reserve to the metabolic requirement during exercise in advanced heart failure with old myocardial infarction.

    Science.gov (United States)

    Yamabe, H; Kobayashi, K; Takata, T; Fukuzaki, H

    1987-03-01

    We studied the metabolic and cardiac responses to exercise by expiratory gas analysis in 40 patients with old myocardial infarction and 33 normal sedentary males. On the basis of exercise energy metabolism, the elevation of the respiratory quotient (RQ; RQ = VCO2/VO2) during exercise is caused by the increase of blood lactate due to the augmented anaerobic metabolism. Functional aerobic impairment (FAI) in our study was significantly advanced in the control group and the NYHA functional class I, class II and class III groups, that is, -2.3 +/- 11.2%, +14.8 +/- 10.4%, +27.8 +/- 13.8% and +49.4 +/- 2.8%, respectively. The delta RQ values were similar among all groups; 0.29 respectively. The delta RQ values were similar among all groups; 0.29 +/- 0.06, 0.28 +/- 0.07, 0.27 +/- 0.07 and 0.29 +/- 0.09, respectively. Functional chronotropic impairment (FCI) for the same groups was -0.9 +/- 7.0%, +1.4 6.1%, +3.8 +/- 4.8% and +8.7 +/- 6.0%, and that of the class III group was significantly larger than that of the control group. Thus, in the class III congestive heart failure group, the chronotropic response to the metabolic requirement was impaired in comparison to the control group. It was concluded that the reduced chronotropic reserve was present in NYHA class III patients with old myocardial infarction, and that this mechanism might contribute to a decrease in the pump reserve of the heart, resulting in further impairment of physical capacity in these patients.

  10. Interim report experience with PT IP-467-C reducing minimum downtime

    Energy Technology Data Exchange (ETDEWEB)

    Fredsall, J.R.

    1963-03-29

    The length of the minimum outage, or period of time during which a reactor must remain subcritical following a shutdown from equilibriu, is a direct function of the available excess reactivity. In reactors with unlimited safety system capacities, it is quite feasible to ``build in`` sufficient excess to allow complete override of the shutdown xenon transient, and thus, in effect, reduce the ``minimum downtime`` to zero. Present Hanford production reactors do not possess this unlimited capacity, and thus total pile reactivity must be restricted by minimum safety strength conditions. Any effort to increase the pile reactivity must therefore be tailored to satisfy existing Total control and Speed-of-control criteria. Production Test IP-467-C. ``Reducing Minimum Downtime,`` was designed to evaluate the economic benefits of a system in which base reactivity can be increased in periods of minimum control requirements, and correspondingly decreased when reactivity or safety considerations become more demanding. The purpose of this document is to summarize initial operating history and results obtained under the production test.

  11. 45 CFR 309.170 - What statistical and narrative reporting requirements apply to Tribal IV-D programs?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What statistical and narrative reporting... (IV-D) PROGRAM Statistical and Narrative Reporting Requirements § 309.170 What statistical and narrative reporting requirements apply to Tribal IV-D programs? (a) Tribes and Tribal...

  12. 32 CFR 37.1040 - When and how do I report information required by § 37.1035?

    Science.gov (United States)

    2010-07-01

    ... OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Executing the Award Reporting Information About the Award § 37.1040 When and how do I report information required by § 37.1035... 32 National Defense 1 2010-07-01 2010-07-01 false When and how do I report information required...

  13. Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Meng Wang

    Full Text Available Routine use of antifibrinolytic agents in spine surgery is still an issue of debate.To gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA and epsilon aminocaproic acid (EACA, traditionally known as Amicar in reducing perioperative blood loss and transfusion requirements in scoliosis surgery.We conducted a systematic review and meta-analysis for randomized controlled trials (RCTs, retrospective case-control studies, and retrospective cohort studies on the use of antifibrinolytic agents in scoliosis surgery by searching in the MEDLINE and EMBASE databases and the Cochrane Database of Systematic Reviews and Controlled Trials of papers published from January 1980 through July 2014. Safety of the antifibrinolytic agents was evaluated in all included studies, while efficacy was evaluated in RCTs.Eighteen papers with a total of 1,158 patients were eligible for inclusion in this study. Among them, 8 RCTs with 450 patients were included for evaluation of pharmacologic efficacy (1 RCT was excluded because of a lack of standard deviation data. Mean blood loss was reduced in patients with perioperative use of antifibrinolytic agents by 409.25 ml intraoperatively (95% confidence interval [CI], 196.57-621.94 ml, 250.30 ml postoperatively (95% CI, 35.31-465.30, and 601.40 ml overall (95% CI, 306.64-896.16 ml. The mean volume of blood transfusion was reduced by 474.98 ml (95% CI, 195.30-754.67 ml. The transfusion rate was 44.6% (108/242 in the patients with antifibrinolytic agents and 68.3% (142/208 in the patients with placebo. (OR 0.38; 95% CI; 0.25-0.58; P<0.00001, I2 = 9%. All studies were included for evaluation of safety, with a total of 8 adverse events reported overall (4 in the experimental group and 4 in the control group.The systematic review and meta-analysis indicated that aprotinin, TXA, and EACA all significantly reduced perioperative blood loss and transfusion requirements

  14. Do walking strategies to increase physical activity reduce reported sitting in workplaces: a randomized control trial

    Directory of Open Access Journals (Sweden)

    Burton Nicola W

    2009-07-01

    Full Text Available Abstract Background Interventions designed to increase workplace physical activity may not automatically reduce high volumes of sitting, a behaviour independently linked to chronic diseases such as obesity and type II diabetes. This study compared the impact two different walking strategies had on step counts and reported sitting times. Methods Participants were white-collar university employees (n = 179; age 41.3 ± 10.1 years; 141 women, who volunteered and undertook a standardised ten-week intervention at three sites. Pre-intervention step counts (Yamax SW-200 and self-reported sitting times were measured over five consecutive workdays. Using pre-intervention step counts, employees at each site were randomly allocated to a control group (n = 60; maintain normal behaviour, a route-based walking group (n = 60; at least 10 minutes sustained walking each workday or an incidental walking group (n = 59; walking in workday tasks. Workday step counts and reported sitting times were re-assessed at the beginning, mid- and endpoint of intervention and group mean± SD steps/day and reported sitting times for pre-intervention and intervention measurement points compared using a mixed factorial ANOVA; paired sample-t-tests were used for follow-up, simple effect analyses. Results A significant interactive effect (F = 3.5; p t = 3.9, p t = 2.5, p Conclusion Compared to controls, both route and incidental walking increased physical activity in white-collar employees. Our data suggests that workplace walking, particularly through incidental movement, also has the potential to decrease employee sitting times, but there is a need for on-going research using concurrent and objective measures of sitting, standing and walking.

  15. 45 CFR 286.285 - How do the data collection and reporting requirements affect Public Law 102-477 Tribes?

    Science.gov (United States)

    2010-10-01

    ... requirements affect Public Law 102-477 Tribes? 286.285 Section 286.285 Public Welfare Regulations Relating to... Requirements § 286.285 How do the data collection and reporting requirements affect Public Law 102-477 Tribes? (a) A Tribe that consolidates its Tribal TANF program into a Public-Law 102-477 plan is required...

  16. Recognizing and reporting vertebral fractures: reducing the risk of future osteoporotic fractures

    Energy Technology Data Exchange (ETDEWEB)

    Lentle, B.C. [Univ. of British Columbia, Dept. of Radiology, Vancouver, British Columbia (Canada); Brown, J.P. [Laval Univ., Dept. of Medicine, Sainte-Foy, Quebec (Canada); Khan, A. [McMaster Univ., Dept. of Medicine, Hamilton, Ontario (Canada)]. E-mail: blentle@shaw.ca (and others)

    2007-02-15

    Given the increasing evidence that vertebral fractures are underdiagnosed and not acted on, Osteoporosis Canada and the Canadian Association of Radiologists initiated a project to develop and publish a set of recommendations to promote and facilitate the diagnosis and reporting of vertebral fractures. The identification of spinal fractures is not uniform. More than 65% of vertebral fractures cause no symptoms. It is also apparent that vertebral fractures are inadequately recognized when the opportunity for diagnosis arises fortuitously. It is to patients' benefit that radiologists report vertebral fractures evident on a chest or other radiograph, no matter how incidental to the immediate clinical indication for the examination. The present recommendations can help to close the gap in care in recognizing and treating vertebral fractures, to prevent future fractures and thus reduce the burden of osteoporosis-related morbidity and mortality, as well as fracture-related costs to the health care system. Several studies indicate that a gap exists in regard to the diagnosis of vertebral fractures and the clinical response following such diagnosis. All recommendations presented here are based on consensus. These recommendations were developed by a multidisciplinary working group under the auspices of the Scientific Advisory Council of Osteoporosis Canada and the Canadian Association of Radiologists. Prevalent vertebral fractures have important clinical implications in terms of future fracture risk. Recognizing and reporting fractures incidental to radiologic examinations done for other reasons has the potential to reduce health care costs by initiating further steps in osteoporosis diagnosis and appropriate therapy. Physicians should be aware of the importance of vertebral fracture diagnosis in assessing future osteoporotic fracture risk. Vertebral fractures incidental to radiologic examinations done for other reasons should be identified and reported. Vertebral

  17. Reporting quality of survival analyses in medical journals still needs improvement. A minimal requirements proposal.

    Science.gov (United States)

    Abraira, Víctor; Muriel, Alfonso; Emparanza, José I; Pijoan, José I; Royuela, Ana; Plana, María Nieves; Cano, Alejandra; Urreta, Iratxe; Zamora, Javier

    2013-12-01

    We reviewed publications with two main objectives: to describe how survival analyses are reported across medical journal specialties and to evaluate changes in reporting across periods and journal specialties. Systematic review of clinical research articles published in 1991 and 2007, in 13 high-impact medical journals. The number of articles performing survival analysis published in 1991 (104) and 2007 (240) doubled (17% vs. 33.5%; P = 0.000), although not uniformly across specialties. The percentage of studies using regression models and the number of patients included also increased. The presentation of results improved, although only the reporting of precision of effect estimates reached satisfactory levels (53.1% in 1991 vs. 94.2% in 2007; P = 0.000). Quality of reporting also varied across specialties; for example, cardiology articles were less likely than oncology ones to discuss sample size estimation (odds ratio = 0.12; 95% confidence interval: 0.05, 0.30). We also detected an interaction effect between period and specialty regarding the likelihood of reporting precision of curves and precision of effect estimates. The application of survival analysis to medical research data is increasing, whereas improvement in reporting quality is slow. We propose a list of minimum requirements for improved application and description of survival analysis. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. THE NEW EU ACCOUNTING DIRECTIVE – A COMPARATION OF REPORTING REQUIREMENTS

    Directory of Open Access Journals (Sweden)

    MARIUS DEAC

    2014-05-01

    Full Text Available The adoption of Directive 2013/34/EU constitutes the materialization of a modernization process of the Directive 78/660/EEC and Directive 83/349/EEC that has started in 2009. The new accounting directive replaces the two accounting directives and sets the requirements for both individual and consolidated financial statements. It also introduces a new category of entities “micro-undertakings” in order to implement the requirements of Directive 2012/6/EU. The paper tries to summarize and compare the typologies of enterprises and groups defined in the old and new accounting directives as well as in the Romanian accounting system (RAS. It also compares the requirements of both the new and the old accounting directives as well as RAS regarding the structure and presentation of the annual financial statements. European Union (EU wide, about 99% of the enterprises fall into micro and small categories and might benefit from the simplifications of preparation and publication requirements of the annual financial statements. They will also be exempted from the requirements of auditing their financial statements. Only 1.21% of the enterprises in Europe will be classified as medium and large and will be required to prepare and publish a full set of annual financial statements and to audit their financial statements. If Romania will opt for reducing the administrative burdens for micro entities and implement simplifications for micro-entities as they were defined in the EU directive 2013/34/EU, the thresholds would have to be dramatically increased and many more enterprises will be reclassified as micro instead of small or medium enterprises.

  19. IG Statement: Arthur A. Elkins, Jr., on OIG report Early Warning Report: Main EPA Headquarters Warehouse in Landover, Maryland, Requires Immediate EPA Attention

    Science.gov (United States)

    Statement of Inspector General Arthur A. Elkins, Jr., on the Office of Inspector General (OIG) report Early Warning Report: Main EPA Headquarters Warehouse in Landover, Maryland, Requires Immediate EPA Attention.

  20. Capital requirements for the transportation of energy materials: 1979 ARC estimates. Draft final report

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-13

    This report contains TERA's estimates of capital requirements to transport natural gas, crude oil, petroleum products, and coal in the United States by 1990. The low, medium, and high world-oil-price scenarios from the EIA's Mid-range Energy Forecasting System (MEFS), as used in the 1979 Annual Report to Congress (ARC), were provided as a basis for the analysis and represent three alternative futures. TERA's approach varies by energy commodity to make best use of the information and analytical tools available. Summaries of transportation investment requirements through 1990 are given. Total investment requirements for three modes (pipelines, rails, waterways and the three energy commodities can accumulate to a $49.9 to $50.9 billion range depending on the scenario. The scenarios are distinguished primarily by the world price of oil which, given deregulation of domestic oil prices, affects US oil prices even more profoundly than in the past. The high price of oil, following the evidence of the last year, is projected to hold demand for oil below the recent past.

  1. MORE - Management of requirements in NPP modernisation projects. Project report 2006

    Energy Technology Data Exchange (ETDEWEB)

    Thunem, A.P.J.; Thunem, H.P.J. [IFE (Norway); Valkonen, J. [VTT (Finland)

    2007-02-15

    The purpose of the report is to document the work and related activities in the period January 1 December 31 in 2006, including dissemination activities. The work in this period has been concentrated on further research for adopting an approach for dependable requirements engineering and its supporting tool. The majority of the efforts in 2006, however, was spent on making the researchers, developers, utilities and licensees more aware of the importance of the area of requirements engineering, and in that respect organising an international seminar on dependable requirements engineering. This seminar was defined as a deliverable in the Activity Plan for 2006 and became also the most important deliverable for 2006. Therefore, this report naturally features a detailed summary of the seminar, which proved to be a true success and at the same time a door opener for more initiatives within the topic, proposed by several participants. More efforts within dissemination of the background and objectives of the project MORE within the nuclear community and towards NPPs that do carry out modernisation projects continued to be one important focus. (au)

  2. Tennessee’s 3-Star Report: Using Available Data Systems to Reduce Missed Opportunities to Vaccinate Preteens

    Science.gov (United States)

    Moore, Kelly L.; Fankhauser, Melissa K.; Hull, Pamela C.

    2016-01-01

    All preteens should receive tetanus–diphtheria–pertussis vaccine (Tdap), quadrivalent meningococcal vaccine (Men-ACWY), and the human papillomavirus (HPV) cancer vaccine series. In Tennessee, HPV vaccination rates have stagnated at low levels for a decade. Three fundamental strategies to reduce missed opportunities for immunization include administering all recommended vaccines at the same visit, making strong recommendations for vaccines, and auditing and feedback. In Tennessee, during each summer, a surge of preteens visit local health departments (LHDs) to receive a required Tdap vaccine before entering seventh grade, presenting an opportunity to administer Men-ACWY and HPV. The Tennessee Immunization Program (TIP) coined the term “3-Star visit” for such encounters and developed a monthly report to track them using data from the Patient Tracking Billing Management Information System (PTBMIS) used by LHDs across Tennessee. Implementation of this quality improvement report has correlated with a substantial increase in 3-Star visits from 2013 to 2016, particularly during the summer months. PMID:27980415

  3. International shock-wave database project : report of the requirements workshop.

    Energy Technology Data Exchange (ETDEWEB)

    Aidun, John Bahram (Institute of Problems of chemical Physics of Russian Academy of Sciences); Lomonosov, Igor V. (Institute of Problems of chemical Physics of Russian Academy of Sciences); Levashov, Pavel R. (Joint Institute for High Temperatures of Russian Academy of Sciences)

    2012-03-01

    We report on the requirements workshop for a new project, the International Shock-Wave database (ISWdb), which was held October 31 - November 2, 2011, at GSI, Darmstadt, Germany. Participants considered the idea of this database, its structure, technical requirements, content, and principles of operation. This report presents the consensus conclusions from the workshop, key discussion points, and the goals and plan for near-term and intermediate-term development of the ISWdb. The main points of consensus from the workshop were: (1) This international database is of interest and of practical use for the shock-wave and high pressure physics communities; (2) Intermediate state information and off-Hugoniot information is important and should be included in ISWdb; (3) Other relevant high pressure and auxiliary data should be included to the database, in the future; (4) Information on the ISWdb needs to be communicated, broadly, to the research community; and (5) Operating structure will consist of an Advisory Board, subject-matter expert Moderators to vet submitted data, and the database Project Team. This brief report is intended to inform the shock-wave research community and interested funding agencies about the project, as its success, ultimately, depends on both of these groups finding sufficient value in the database to use it, contribute to it, and support it.

  4. Unconventional oil and gas spills: Risks, mitigation priorities, and state reporting requirements

    Science.gov (United States)

    Patterson, Lauren A.; Konschnik, Katherine E.; Wiseman, Hannah; Fargione, Joseph; Maloney, Kelly O.; Kiesecker, Joseph M.; Nicot, Jean-Philippe; Baruch-Mordo, Sharon; Entrekin, Sally; Trainor, Anne; Saiers, James

    2017-01-01

    Rapid growth in unconventional oil and gas (UOG) has produced jobs, revenue, and energy, but also concerns over spills and environmental risks. We assessed spill data from 2005 to 2014 at 31 481 UOG wells in Colorado, New Mexico, North Dakota, and Pennsylvania. We found 2–16% of wells reported a spill each year. Median spill volumes ranged from 0.5 m3 in Pennsylvania to 4.9 m3 in New Mexico; the largest spills exceeded 100 m3. Seventy-five to 94% of spills occurred within the first three years of well life when wells were drilled, completed, and had their largest production volumes. Across all four states, 50% of spills were related to storage and moving fluids via flowlines. Reporting rates varied by state, affecting spill rates and requiring extensive time and effort getting data into a usable format. Enhanced and standardized regulatory requirements for reporting spills could improve the accuracy and speed of analyses to identify and prevent spill risks and mitigate potential environmental damage. Transparency for data sharing and analysis will be increasingly important as UOG development expands. We designed an interactive spills data visualization tool (http://snappartnership.net/groups/hydraulic-fracturing/webapp/spills.html) to illustrate the value of having standardized, public data.

  5. 10 CFR 905.17 - What are the requirements for the energy efficiency and/or renewable energy report (EE/RE report...

    Science.gov (United States)

    2010-01-01

    ... renewable energy report (EE/RE report) alternative? 905.17 Section 905.17 Energy DEPARTMENT OF ENERGY ENERGY... energy efficiency and/or renewable energy report (EE/RE report) alternative? (a) Requests to submit an EE..., including any requirements for documenting customer energy efficiency and renewable energy......

  6. JET-ISX-B beryllium limiter experiment safety analysis report and operational safety requirements

    Energy Technology Data Exchange (ETDEWEB)

    Edmonds, P.H.

    1985-09-01

    An experiment to evaluate the suitability of beryllium as a limiter material has been completed on the ISX-B tokamak. The experiment consisted of two phases: (1) the initial operation and characterization in the ISX experiment, and a period of continued operation to the specified surface fluence (10/sup 22/ atoms/cm/sup 2/) of hydrogen ions; and (2) the disassembly, decontamination, or disposal of the ISX facility. During these two phases of the project, the possibility existed for beryllium and/or beryllium oxide powder to be produced inside the vacuum vessel. Beryllium dust is a highly toxic material, and extensive precautions are required to prevent the release of the beryllium into the experimental work area and to prevent the contamination of personnel working on the device. Details of the health hazards associated with beryllium and the appropriate precautions are presented. Also described in appendixes to this report are the various operational safety requirements for the project.

  7. Seasonal energy-storage requirements. Final report for Project 8982, June 30, 1976--September 30, 1976

    Energy Technology Data Exchange (ETDEWEB)

    1977-08-01

    This report quantifies the residential heating and cooling markets by census region and type of fuel. It also makes projections of residential heating and cooling demand to the year 2000 and estimates the effect of electrification scenarios on reducing the end-use consumption of fuels for heating and cooling purposes. Oil and natural gas storage capacity and costs are also reviewed for the residential sector to determine what price electric seasonal storage must reach to be competitive with its alternatives. Possible electric storage technologies are reviewed for their applicability to seasonal storage, and areas for further research are suggested.

  8. Technology and Research Requirements for Combating Human Trafficking: Enhancing Communication, Analysis, Reporting, and Information Sharing

    Energy Technology Data Exchange (ETDEWEB)

    Kreyling, Sean J.; West, Curtis L.; Olson, Jarrod

    2011-03-17

    DHS’ Science & Technology Directorate directed PNNL to conduct an exploratory study on the domain of human trafficking in the Pacific Northwest in order to examine and identify technology and research requirements for enhancing communication, analysis, reporting, and information sharing – activities that directly support efforts to track, identify, deter, and prosecute human trafficking – including identification of potential national threats from smuggling and trafficking networks. This effort was conducted under the Knowledge Management Technologies Portfolio as part of the Integrated Federal, State, and Local/Regional Information Sharing (RISC) and Collaboration Program.

  9. SOLERAS - Solar Controlled Environment Agriculture Project. Final report, Volume 5. Science Applications, Incorporated system requirements definition

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    This report sets forth the system requirements for a Solar Controlled-Environment Agriculture System (SCEAS) Project. In the report a conceptual baseline system description for an engineering test facility is given. This baseline system employs a fluid roof/roof filter in combination with a large storage tank and a ground water heat exchanger in order to provide cooling and heating as needed. Desalination is accomplished by pretreatment followed by reverse osmosis. Energy is provided by means of photovoltaics and wind machines in conjunction with storage batteries. Site and climatic data needed in the design process are given. System performance specifications and integrated system design criteria are set forth. Detailed subsystem design criteria are presented and appropriate references documented.

  10. Ventilation Requirements for Control of Occupancy Odor and Tobacco Smoke Odor: Laboratory Studies Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Cain, W. S. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Isseroff, R. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Leaderere, B. P. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lipsitt, E. D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Huey, R. J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Perlman, D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bergland, L. G. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dunn, J. D. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    1981-04-01

    A sensitive chemical analysis of the air in a building will characteristically reveal a large number of organic substances, many at concentrations too low to have discernible biological impact. If the concentrations of the chemicals increase, the first sign of their presence may occur via the sense of smell. The air may become odorous. In the general absence of any better or faster indicator, smell will serve as the principal means to decide whether the air in a room is acceptable. Accordingly, this modality has long figured directly or indirectly in the choice of ventilation rates. The cost of ventilation, on the average more than 25% of the operating cost of a building, increases proportionally with the cost of energy and therefore provides a strong incentive to search for energy efficiency. A previous report reviewed the literature relevant to odor perception, odor control, and ventilation (1). The report highlighted prospects for research that might point to ways to achieve both acceptable air quality and energy efficiency in ventilation. The present report provides an account of laboratory research stimulated by that review. The report focuses on ventilation requirements for occupancy odor (Part l) and tobacco smoke odor (Part 2), and offers some preliminary observations on how filtration may aid ventilation (Part 3).

  11. 40 CFR 51.10 - How does my state report emissions that are required by the NOX SIP Call?

    Science.gov (United States)

    2010-07-01

    ... are required by the NOX SIP Call? 51.10 Section 51.10 Protection of Environment ENVIRONMENTAL... does my state report emissions that are required by the NOX SIP Call? The District of Columbia and states that are subject to the NOX SIP Call § 51.121) are subject to the emissions reporting...

  12. 75 FR 17918 - Submission for OMB Review; American Recovery and Reinvestment Act-One-Time Reporting Requirements...

    Science.gov (United States)

    2010-04-08

    ...; American Recovery and Reinvestment Act--One-Time Reporting Requirements for First-Tier Subcontractors...--One-time Reporting Requirements for First-tier Subcontractors. A request for public comments was... technological collection techniques or other forms of information technology. DATES: Submit comments on...

  13. Tai chi training reduces self-report of inattention in healthy young adults.

    Science.gov (United States)

    Converse, Alexander K; Ahlers, Elizabeth O; Travers, Brittany G; Davidson, Richard J

    2014-01-01

    It is important to identify effective non-pharmacological alternatives to stimulant medications that reduce symptoms of attention deficit hyperactivity disorder (ADHD). In this study of healthy young adults, we measured the effects of training in tai chi, which involves mindful attention to the body during movement. Using a non-randomized, controlled, parallel design, students in a 15-week introductory tai chi course (n = 28) and control participants (n = 44) were tested for ADHD indicators and cognitive function at three points over the course of the 15-weeks. The tai chi students' self-report of attention, but not hyperactivity-impulsivity, improved compared to controls. At baseline, inattention correlated positively with reaction time variability in an affective go/no-go task across all participants, and improvements in attention correlated with reductions in reaction time variability across the tai chi students. Affective bias changed in the tai chi students, as reaction times to positive- and negative-valenced words equalized over time. These results converge to suggest that tai chi training may help improve attention in healthy young adults. Further studies are needed to confirm these results and to evaluate tai chi as therapy for individuals with ADHD.

  14. Tai chi training reduces self-report of inattention in healthy young adults

    Directory of Open Access Journals (Sweden)

    Alexander K. Converse

    2014-01-01

    Full Text Available It is important to identify effective non-pharmacological alternatives to stimulant medications that reduce symptoms of attention deficit hyperactivity disorder (ADHD. In this study of healthy young adults, we measured the effects of training in tai chi, which involves mindful attention to the body during movement. Using a non-randomized, controlled, parallel design, students in a 15-week introductory tai chi course (n=28 and control participants (n=44 were tested for ADHD indicators and cognitive function at three points over the course of the 15 weeks. The tai chi students' self-report of attention, but not hyperactivity-impulsivity, improved compared to controls. At baseline, inattention correlated positively with reaction time variability in an affective go/no-go task across all participants, and improvements in attention correlated with reductions in reaction time variability across the tai chi students. Affective bias changed in the tai chi students, as reaction times to positive- and negative-valenced words equalized over time. These results converge to suggest that tai chi training may help improve attention in healthy young adults. Further studies are needed to confirm these results and to evaluate tai chi as therapy for individuals with ADHD.

  15. Prefrontal electrical stimulation in nondepressed reduces levels of reported negative affects from daily stressors

    Directory of Open Access Journals (Sweden)

    Adelaide H Austin

    2016-03-01

    Full Text Available Negative emotional responses to the daily life stresses have cumulative effects which, in turn, impose wide-ranging negative constraints on emotional well being and neurocognitive performance (Kalueff et al, 2007, Charles et al, 2013, Nadler et al, 2010. Crucial cognitive functions such as memory and problem solving, as well more short term emotional responses (e.g., anticipation of- and response to- monetary rewards or losses are influenced by mood. The negative impact of these behavioural responses is felt at the individual level, but it also imposes major economic burden on modern healthcare systems. Although much research have been undertaken to understand the underlying mechanisms of depressed mood and design efficient treatment pathways, comparatively little was done to characterize mood modulations that remain within the boundaries of a healthy mental functioning. In one placebo-controlled experiments, we applied daily prefrontal transcranial Direct Current Stimulation (tDCS at five points in time, and found reliable improvements on self-reported mood evaluation. We replicated this finding in an independent double-blinded placebo-controlled experiment and showed that stimulation over a shorter period of time (3 days is sufficient to create detectable mood improvements. Taken together, our data show that repeated bilateral prefrontal tDCS can reduce psychological distress in nondepressed individuals.

  16. Adult scoliosis can be reduced through specific SEAS exercises: a case report

    Directory of Open Access Journals (Sweden)

    Atanasio Salvatore

    2008-12-01

    Full Text Available Abstract Background It has been known since many years that scoliosis can continue to progress after skeletal maturity: the rate of progression has shown to be linear, and it can be used to establish an individual prognosis. Once there is progression there is an indication for treatment: usually it is proposed a surgical one. There are very few papers on an alternative rehabilitation approach; since many years we propose specific SEAS exercises and the aim of this study is to present one case report on this approach. Case presentation All radiographs have been measured blindly twice using the same protractor by one expert physician whose repeatability error proved to be Conclusion A scoliosis curve is made of different components: the structural bony and ligamentous components, and a postural one that counts up to 9° in children, while it has not been quantified in adults. This case shows that when adult scoliosis aggravates it is possible to intervene with specific exercises (SEAS not just to get stability, but to recover last years collapse. The reduction of scoliotic curve through rehabilitation presumably does not indicate a reduction of the bone deformity, but rely on a recovery of the upright postural collapse. This reduction can decrease the chronic asymmetric load on the spine and, in the long run, reduce the risks of progression.

  17. A 17 year-old girl with a demyelinating disease requiring mechanical ventilation: a case report

    Directory of Open Access Journals (Sweden)

    Katsenos Chrysostomos

    2013-01-01

    Full Text Available Abstract Background Demyelinating diseases cause destruction of the myelin sheath, while axons are relatively spared. Pathologically, demyelination can be the result of an inflammatory process, viral infection, acquired metabolic derangement and ischemic insult. Three diseases that can cause inflammatory demyelination of the CNS are: Multiple sclerosis (MS, Acute disseminated encephalomyelitis (ADEM and Acute hemorrhagic leucoencephalitis. Differentiation is not always easy and there is considerable overlaping. Data about adults with acute demyelination requiring ICU admission is limited. Case presentation A 17 year old Greek female was hospitalised in the ICU because of acute respiratory failure requiring mechanical ventilation. She had a history of febrile disease one month before, acute onset of paraplegia, diplopia, progressive arm weakness and dyspnea. Her consciousness was not impaired. A demyelinating central nervous system (CNS disease, possibly post infectious encephalomyelitis (ADEM was the underlying condition. The MRI of the brain disclosed diffused expanded cerebral lesions involving the optic nerve, basal ganglia cerebellum, pons and medulla oblongata. There was also extended involvement of the cervical and thoracic part of the spinal cord. CSF leukocyte count was elevated with lymphocyte predominance. The patient required mechanical ventilation for two months. Then she was transferred to a rehabilitation centre. Three years later she remains paraplegic. Since then she has not suffered any other demyelination attack. Conclusions Demyelinating diseases can cause acute respiratory failure when the spinal cord is affected. Severe forms of these diseases, making necessary ICU admission, is less frequently reported. Intensivists should be aware of the features of these rare diseases.

  18. High level waste storage tank farms/242-A evaporator standards/requirements identification document phase 1 assessment report

    Energy Technology Data Exchange (ETDEWEB)

    Biebesheimer, E., Westinghouse Hanford Co.

    1996-09-30

    This document, the Standards/Requirements Identification Document (S/RID) Phase I Assessment Report for the subject facility, represents the results of an Administrative Assessment to determine whether S/RID requirements are fully addressed by existing policies, plans or procedures. It contains; compliance status, remedial actions, and an implementing manuals report linking S/RID elements to requirement source to implementing manual and section.

  19. Model requirements for estimating and reporting soil C stock changes in national greenhouse gas inventories

    Science.gov (United States)

    Didion, Markus; Blujdea, Viorel; Grassi, Giacomo; Hernández, Laura; Jandl, Robert; Kriiska, Kaie; Lehtonen, Aleksi; Saint-André, Laurent

    2016-04-01

    Globally, soils are the largest terrestrial store of carbon (C) and small changes may contribute significantly to the global C balance. Due to the potential implications for climate change, accurate and consistent estimates of C fluxes at the large-scale are important as recognized, for example, in international agreements such as the United Nations Framework Convention on Climate Change (UNFCCC). Under the UNFCCC and also under the Kyoto Protocol it is required to report C balances annually. Most measurement-based soil inventories are currently not able to detect annual changes in soil C stocks consistently across space and representative at national scales. The use of models to obtain relevant estimates is considered an appropriate alternative under the UNFCCC and the Kyoto Protocol. Several soil carbon models have been developed but few models are suitable for a consistent application across larger-scales. Consistency is often limited by the lack of input data for models, which can result in biased estimates and, thus, the reporting criteria of accuracy (i.e., emission and removal estimates are systematically neither over nor under true emissions or removals) may be met. Based on a qualitative assessment of the ability to meet criteria established for GHG reporting under the UNFCCC including accuracy, consistency, comparability, completeness, and transparency, we identified the suitability of commonly used simulation models for estimating annual C stock changes in mineral soil in European forests. Among six discussed simulation models we found a clear trend toward models for providing quantitative precise site-specific estimates which may lead to biased estimates across space. To meet reporting needs for national GHG inventories, we conclude that there is a need for models producing qualitative realistic results in a transparent and comparable manner. Based on the application of one model along a gradient from Boreal forests in Finland to Mediterranean forests

  20. Guillain-Barré Syndrome with asystole requiring permanent pacemaker: a case report.

    Science.gov (United States)

    Patel, Mehul B; Goyal, Sandeep K; Punnam, Sujeeth R; Pandya, Khyati; Khetarpal, Vipin; Thakur, Ranjan K

    2009-01-06

    Guillain-Barré syndrome is an acute demyelinating disorder of the peripheral nervous system that results from an aberrant immune response directed at peripheral nerves. Autonomic abnormalities in Guillain-Barré syndrome are usually transient and reversible. We present a case of Guillain-Barré syndrome requiring a permanent pacemaker in view of persistent symptomatic bradyarrhythmia. An 18-year-old Caucasian female presented with bilateral lower limb paraesthesias followed by bilateral progressive leg weakness and difficulty in walking. She reported an episode of an upper respiratory tract infection 3 weeks prior to the onset of her neurological symptoms. Diagnosis of Guillain-Barré syndrome was considered and a lumbar puncture was performed. Cerebrospinal fluid revealed albuminocytologic dissociation (increased protein but normal white blood cell count) suggestive of Guillain-Barré syndrome and hence an intravenous immunoglobulin G infusion was started. Within 48 hours, she progressed to complete flaccid quadriparesis with involvement of respiratory muscles requiring mechanical ventilatory support. Whist in the intensive care unit, she developed multiple episodes of bradycardia and asystole requiring a temporary pacemaker. In view of the persistent requirement for the temporary pacemaker for more than 5 days, she received a permanent pacemaker. She returned for follow-up three months after discharge with an intermittent need for ventricular pacing. Guillain-Barré syndrome can result in permanent damage to the cardiac conduction system. Patients with multiple episodes of bradycardia and asystole in the setting of Guillain-Barré syndrome should be evaluated and considered as potential candidates for permanent pacemaker implantation.

  1. Guillain-Barré Syndrome with asystole requiring permanent pacemaker: a case report

    Directory of Open Access Journals (Sweden)

    Patel Mehul B

    2009-01-01

    Full Text Available Abstract Introduction Guillain-Barré syndrome is an acute demyelinating disorder of the peripheral nervous system that results from an aberrant immune response directed at peripheral nerves. Autonomic abnormalities in Guillain-Barré syndrome are usually transient and reversible. We present a case of Guillain-Barré syndrome requiring a permanent pacemaker in view of persistent symptomatic bradyarrhythmia. Case Presentation An 18-year-old Caucasian female presented with bilateral lower limb paraesthesias followed by bilateral progressive leg weakness and difficulty in walking. She reported an episode of an upper respiratory tract infection 3 weeks prior to the onset of her neurological symptoms. Diagnosis of Guillain-Barré syndrome was considered and a lumbar puncture was performed. Cerebrospinal fluid revealed albuminocytologic dissociation (increased protein but normal white blood cell count suggestive of Guillain-Barré syndrome and hence an intravenous immunoglobulin G infusion was started. Within 48 hours, she progressed to complete flaccid quadriparesis with involvement of respiratory muscles requiring mechanical ventilatory support. Whist in the intensive care unit, she developed multiple episodes of bradycardia and asystole requiring a temporary pacemaker. In view of the persistent requirement for the temporary pacemaker for more than 5 days, she received a permanent pacemaker. She returned for follow-up three months after discharge with an intermittent need for ventricular pacing. Conclusion Guillain-Barré syndrome can result in permanent damage to the cardiac conduction system. Patients with multiple episodes of bradycardia and asystole in the setting of Guillain-Barré syndrome should be evaluated and considered as potential candidates for permanent pacemaker implantation.

  2. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

    Directory of Open Access Journals (Sweden)

    Abisambra Jose F

    2010-11-01

    Full Text Available Abstract Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment. However, recent evidence suggests that tau tangles are not the entity responsible for memory loss, rather it is an intermediate tau species that disrupts neuronal function. Thus, efforts to discover therapeutics for tauopathies emphasize soluble tau reductions as well as neuroprotection. Results Here, we found that neuroprotection alone caused by methylene blue (MB, the parent compound of the anti-tau phenothiaziazine drug, Rember™, was insufficient to rescue cognition in a mouse model of the human tauopathy, progressive supranuclear palsy (PSP and fronto-temporal dementia with parkinsonism linked to chromosome 17 (FTDP17: Only when levels of soluble tau protein were concomitantly reduced by a very high concentration of MB, was cognitive improvement observed. Thus, neurodegeneration can be decoupled from tau accumulation, but phenotypic improvement is only possible when soluble tau levels are also reduced. Conclusions Neuroprotection alone is not sufficient to rescue tau-induced memory loss in a transgenic mouse model. Development of neuroprotective agents is an area of intense investigation in the tauopathy drug discovery field. This may ultimately be an unsuccessful approach if soluble toxic tau intermediates are not also reduced. Thus, MB and related compounds, despite their pleiotropic nature, may be the proverbial "magic bullet" because they not only are neuroprotective, but are also able to facilitate soluble tau clearance. Moreover, this shows that neuroprotection is possible without reducing tau levels. This indicates that there is a definitive molecular link between tau and cell death cascades that can be disrupted.

  3. Requirements Elicitation of Passengers With Reduced Mobility for the Design of High Quality, Accessible and Inclusive Public Transport Services

    Directory of Open Access Journals (Sweden)

    Starzyńska Beata

    2015-09-01

    Full Text Available In this article the authors present the methodology adopted and the results obtained in the first stage of the research encompassing focus group interviews (FGI about the needs of public transport users in a selected city (Poznań. The elicitation and assessment of the requirements were carried out for three groups of people with disabilities using public transport in the city of Poznań: blind and partially sighted people, deaf and hearing-impaired people, as well as people with locomotor dysfunctions. A study carried out on the basis of a scenario especially designed for the FGI purpose has made it possible to identify barriers for people with disabilities and, consequently, to formulate their pre-trip,on-trip and post-trip requirements when it comes to urban public transport services. The results will be used to construct a questionnaire to be used further on in the project.

  4. Report on the Depth Requirements for a Massive Detector at Homestake

    Energy Technology Data Exchange (ETDEWEB)

    Kadel, Richard W.; Bernstein, Adam; Blucher, Edward; Cline, David B.; Diwan, Milind V.; Fleming, Bonnie; Kearns, Edward; Klein, Joshua; Lande, Kenneth; Lanni, Francesco; Lissauer, David; McKeown, Robert; Morse, William; Rameika, Regina; Scholberg, Kate; Smy, Michael; Sobel, Henry; Sullivan, Gregory; Svoboda, Robert; Vagins, Mark; Walter, Christopher; Zwaska, Robert

    2008-12-23

    This report provides the technical justification for locating a large detector underground in a US based Deep Underground Science and Engineering Laboratory. A large detector with a fiducial mass greater than 100 kTon will most likely be a multipurpose facility. The main physics justification for such a device is detection of accelerator generated neutrinos, nucleon decay, and natural sources of neutrinos such as solar, atmospheric and supernova neutrinos. The requirement on the depth of this detector will be guided by the rate of signals from these sources and the rate of backgrounds from cosmic rays over a very wide range of energies (from solar neutrino energies of 5 MeV to high energies in the range of hundreds of GeV). For the present report, we have examined the depth requirement for a large water Cherenkov detector and a liquid argon time projection chamber. There has been extensive previous experience with underground water Cherenkov detectors such as IMB, Kamioka, and most recently, Super-Kamiokande which has a fiducial mass of 22 kTon and a total mass of 50 kTon at a depth of 2700 meters-water-equivalent in a mountain. Projections for signal and background capability for a larger and deeper(or shallower) detectors of this type can be scaled from these previous detectors. The liquid argon time projection chamber has the advantage of being a very fine-grained tracking detector, which should provide enhanced capability for background rejection. We have based background rejection on reasonable estimates of track and energy resolution, and in some cases scaled background rates from measurements in water. In the current work we have taken the approach that the depth should be sufficient to suppress the cosmogenic background below predicted signal rates for either of the above two technologies. Nevertheless, it is also clear that the underground facility that we are examining must have a long life and will most likely be used either for future novel uses of the

  5. Report on the Depth Requirements for a Massive Detector at Homestake

    Energy Technology Data Exchange (ETDEWEB)

    Bernstein,A.; Blucher, E.; Cline, D. B.; Diwan, M. V.; Fleming, b.; Kadel, R.; Kearns, E.; Klein, J.; Lande, K.; Lanni, F.; Lissauer, D.; McKeown, R.; Morse, W.; Radeika, R.; Scholberg, K.; Smy, M.; Sobel, H.; Sullivan, G.; Svoboda, R.; Vagins, M.; Walter, C.; Zwaska, R.

    2008-12-22

    This report provides the technical justification for locating a large detector underground in a US based Deep Underground Science and Engineering Laboratory. A large detector with a fiducial mass greater than 100 kTon will most likely be a multipurpose facility. The main physics justification for such a device is detection of accelerator generated neutrinos, nucleon decay, and natural sources of neutrinos such as solar, atmospheric and supernova neutrinos. The requirement on the depth of this detector will be guided by the rate of signals from these sources and the rate of backgrounds from cosmic rays over a very wide range of energies (from solar neutrino energies of 5 MeV to high energies in the range of tens of GeV). For the present report, we have examined the depth requirement for a large water Cherenkov detector and a liquid argon time projection chamber. There has been extensive previous experience with underground water Cherenkov detectors such as IMB, Kamioka, and most recently, Super-Kamiokande which has a fiducial mass of 22 kTon and a total mass of 50 kTon at a depth of 2700 meters-water-equivalent. Projections for signal and background capability for a larger and deeper (or shallower) detectors of this type can be scaled from these previous detectors. The liquid argon time projection chamber has the advantage of being a very fine-grained tracking detector, which provides enhanced capability for background rejection. In the current work we have taken the approach that the depth should be sufficient to suppress the cosmogenic background below predicted signal rates for either of the above two technologies. Nevertheless, it is also clear that the underground facility that we are examining must have a long life and will most likely be used either for future novel uses of the currently planned detectors or new technologies. Therefore the depth requirement also needs to be made on the basis of sound judgment regarding possible future use. In particular, the

  6. Using reporting requirements to improve employer wellness incentives and their regulation.

    Science.gov (United States)

    Madison, Kristin; Schmidt, Harald; Volpp, Kevin G

    2014-10-01

    Employer interest in offering financial incentives for healthy behaviors has been increasing. Some employers have begun to tie health plan-based rewards or penalties to standards involving tobacco use or biometric measures such as body mass index. The Patient Protection and Affordable Care Act attempts to strike a balance between the potential benefits and risks of wellness incentive programs by permitting these incentives but simultaneously limiting their use. Evidence about the implications of the newest generation of incentive programs for health, health costs, and burdens on individual employees will be critical for informing both private and public decision makers. After describing the many pieces of information that would be valuable for assessing these programs, this article proposes more narrowly targeted reporting requirements that could facilitate incentive program development, evaluation, and oversight. Copyright © 2014 by Duke University Press.

  7. Bilateral lower extremity gangrene requiring amputation associated with heparin-induced thrombocytopenia: a case report.

    Science.gov (United States)

    Dickinson, Brian P; Lawrence, Peter F

    2007-01-01

    Heparin is a common cause of thrombocytopenia in hospitalized patients. Between 10% and 15% of patients receiving therapeutic doses of heparin develop thrombocytopenia. Heparin-induced thrombocytopenia (HIT) can cause severe bleeding and thrombosis owing to intravascular platelet aggregation. HIT must be distinguished from other causes of thrombocytopenia. Importantly, heparin use is often associated with an early fall in the platelet count that usually occurs within the first 4 days of initiation and recovers without cessation of heparin treatment. This nonimmune heparin-associated thrombocytopenia has not been found to be associated with thrombosis and does not necessitate discontinuation of heparin. The authors present a case report of a 70-year-old man who received heparin therapy following aortic tissue valve replacement and aortic root repair with graft and developed bilateral lower extremity arterial clots 6 days postoperatively in the setting of positive heparin antibody titers. Ultimately the patient required bilateral above-knee amputations.

  8. Bilateral lower extremity gangrene requiring amputation associated with heparin-induced thrombocytopenia--a case report.

    Science.gov (United States)

    Dickinson, Brian P; De Ugarte, Daniel A; Reil, Todd D; Beseth, Bryce D; Lawrence, Peter F

    2006-01-01

    Heparin use, both prophylactically and therapeutically, is prevalent among hospitalized patients. Patients on heparin may develop a thrombocytopenia that is self-limited. Fewer patients develop a heparin-induced thrombocytopenia that can cause severe bleeding and thrombosis owing to intravascular platelet aggregation. The authors present a case report of heparin-induced thrombocytopenia in a patient who underwent aortic arch and aortic valve replacement that resulted in bilateral above-knee amputations. The patient developed limb ischemia related to heparin-associated thrombosis, but had a delay in antibody seroconversion. Early and accurate diagnosis of heparin-induced thrombocytopenia requires a high clinical suspicion and may be present despite the absence of serum antibodies.

  9. Diminished brain synaptic plasma membrane Ca(2+)-ATPase activity in rats with streptozocin-induced diabetes: association with reduced anesthetic requirements.

    Science.gov (United States)

    Janicki, P K; Horn, J L; Singh, G; Franks, W T; Franks, J J

    1994-01-01

    Recent evidence suggests that chronic hyperglycemia may inhibit plasma membrane Ca(2+)-ATPase (PMCA) in cells from several tissues. Inhalational anesthetics (IA) can inhibit brain synaptic PMCA activity. We proposed that diabetic rats may manifest chronic inhibition of brain synaptic PMCA and thus provide a model for testing the hypothesis that synaptic PMCA plays a key role in IA pharmacodynamics. Ca2+ pumping activity of PMCA was measured in cerebral synaptic plasma membrane (SPM) vesicles prepared from rats with streptozocin (STZ)-induced diabetes and from control, normoglycemic rats. Dose requirements for halothane and xenon were estimated in treated and untreated rats. Brain PMCA activity in hyperglycemic rats was depressed by about 8.4%, compared to controls. In vitro glycation also caused a significant decrease in PMCA pumping activity. Halothane requirement for STZ-hyperglycemic rats was dramatically reduced to about 65% of control. Xenon requirement was also significantly reduced, to 88% of control. Correlation of IA dose with percent glycated hemoglobin for each rat revealed a strong association between reduced requirements for halothane or xenon and increased protein glycation. These results indicate that inhibition of brain synaptic PMCA in chronically hyperglycemic rats is associated with a significant reduction in IA requirement.

  10. Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report.

    Science.gov (United States)

    Ryu, Changwan; Herzog, Erica L; Pan, Hongyi; Homer, Robert; Gulati, Mridu

    2017-02-13

    BACKGROUND Laryngeal sarcoidosis is a rare extrapulmonary manifestation of sarcoidosis, accounting for 0.33-2.1% of cases. A life-threatening complication of laryngeal sarcoidosis is upper airway obstruction. In this report we describe our experience in the acute and chronic care of a patient who required an emergent tracheostomy, with the aim to provide further insight into this difficult to manage disease. CASE REPORT A 37-year-old African American female with a 10-year history of stage 1 sarcoidosis presented with severe dyspnea. Laryngeal sarcoidosis was diagnosed three years previously, and she remained stable on low-dose prednisone until six months prior to admission, at which time she self-discontinued her prednisone for the homeopathic treatment Nopalea cactus juice. Her physical examination was concerning for impending respiratory failure as she presented with inspiratory stridor and hoarseness. Laryngoscopy showed a retroflexed epiglottis obstructing the glottis with edematous arytenoids and aryepiglottic folds. Otolaryngology performed an emergent tracheostomy to secure her airway and obtained epiglottic biopsies, which were consistent with sarcoidosis. She was eventually discharged home on prednisone 60 mg daily. Following months of corticosteroids, a laryngoscopy showed the epiglottis continuing to obstruct the glottis. The addition of methotrexate to a tapered dosage of prednisone 10 mg daily was unsuccessful, and she remains on prednisone 20 mg daily for disease control. CONCLUSIONS Laryngeal sarcoidosis, a rare extrapulmonary manifestation of sarcoidosis, uncommonly presents as the life-threatening complication of complete upper airway obstruction. As such, laryngeal sarcoidosis is associated with significant morbidity and mortality, requiring a high index of suspicion for timely diagnosis and treatment.

  11. Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report

    Science.gov (United States)

    Ryu, Changwan; Herzog, Erica L.; Pan, Hongyi; Homer, Robert; Gulati, Mridu

    2017-01-01

    Patient: Female, 35 Final Diagnosis: Laryngeal sarcoidosis Symptoms: Hoarseness • stridor Medication: — Clinical Procedure: Tracheostomy Specialty: Otolaryngology Objective: Rare disease Background: Laryngeal sarcoidosis is a rare extrapulmonary manifestation of sarcoidosis, accounting for 0.33–2.1% of cases. A life-threatening complication of laryngeal sarcoidosis is upper airway obstruction. In this report we describe our experience in the acute and chronic care of a patient who required an emergent tracheostomy, with the aim to provide further insight into this difficult to manage disease. Case Report: A 37-year-old African American female with a 10-year history of stage 1 sarcoidosis presented with severe dyspnea. Laryngeal sarcoidosis was diagnosed three years previously, and she remained stable on low-dose prednisone until six months prior to admission, at which time she self-discontinued her prednisone for the homeopathic treatment Nopalea cactus juice. Her physical examination was concerning for impending respiratory failure as she presented with inspiratory stridor and hoarseness. Laryngoscopy showed a retroflexed epiglottis obstructing the glottis with edematous arytenoids and aryepiglottic folds. Otolaryngology performed an emergent tracheostomy to secure her airway and obtained epiglottic biopsies, which were consistent with sarcoidosis. She was eventually discharged home on prednisone 60 mg daily. Following months of corticosteroids, a laryngoscopy showed the epiglottis continuing to obstruct the glottis. The addition of methotrexate to a tapered dosage of prednisone 10 mg daily was unsuccessful, and she remains on prednisone 20 mg daily for disease control. Conclusions: Laryngeal sarcoidosis, a rare extrapulmonary manifestation of sarcoidosis, uncommonly presents as the life-threatening complication of complete upper airway obstruction. As such, laryngeal sarcoidosis is associated with significant morbidity and mortality, requiring a high index

  12. Westinghouse Hanford Company safety analysis reports and technical safety requirements upgrade program

    Energy Technology Data Exchange (ETDEWEB)

    Busche, D.M.

    1995-09-01

    During Fiscal Year 1992, the US Department of Energy, Richland Operations Office (RL) separately transmitted the following US Department of Energy (DOE) Orders to Westinghouse Hanford Company (WHC) for compliance: DOE 5480.21, ``Unreviewed Safety Questions,`` DOE 5480.22, ``Technical Safety Requirements,`` and DOE 5480.23, ``Nuclear Safety Analysis Reports.`` WHC has proceeded with its impact assessment and implementation process for the Orders. The Orders are closely-related and contain some requirements that are either identical, similar, or logically-related. Consequently, WHC has developed a strategy calling for an integrated implementation of the three Orders. The strategy is comprised of three primary objectives, namely: Obtain DOE approval of a single list of DOE-owned and WHC-managed Nuclear Facilities, Establish and/or upgrade the ``Safety Basis`` for each Nuclear Facility, and Establish a functional Unreviewed Safety Question (USQ) process to govern the management and preservation of the Safety Basis for each Nuclear Facility. WHC has developed policy-revision and facility-specific implementation plans to accomplish near-term tasks associated with the above strategic objectives. This plan, which as originally submitted in August 1993 and approved, provided an interpretation of the new DOE Nuclear Facility definition and an initial list of WHC-managed Nuclear Facilities. For each current existing Nuclear Facility, existing Safety Basis documents are identified and the plan/status is provided for the ISB. Plans for upgrading SARs and developing TSRs will be provided after issuance of the corresponding Rules.

  13. Tumefactive multiple sclerosis requiring emergency craniotomy: case report and literature review.

    Science.gov (United States)

    Munarriz, Pablo M; Castaño-Leon, Ana M; Martinez-Perez, Rafael; Hernandez-Lain, Aurelio; Ramos, Ana; Lagares, Alfonso

    2013-01-01

    Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, characterized by focal neurological dysfunction with a relapsing and remitting course. Tumor-like presentation of MS (or "tumefactive"/"pseudotumoral" presentation) has been described before with a certain frequency; it consists of a large single plaque (>2cm) with presence of edema and mass effect and it is hard to distinguish from a brain tumor. However, we present a very rare case of a 53-year-old woman with a right temporal mass that turned out to be a MS plaque, who deteriorated within hours (brain herniation with loss of consciousness and unilateral mydriasis) and required an emergency craniotomy. We also present a review of the literature. It appears that only 4 cases of emergency craniotomy/craniectomy required in a patient with a tumor-like MS plaque have been reported before. Copyright © 2012 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

  14. A new test environment for the SOFIA secondary mirror assembly to reduce the required time for in-flight testing

    Science.gov (United States)

    Lammen, Yannick; Reinacher, Andreas; Brewster, Rick; Greiner, Benjamin; Graf, Friederike; Krabbe, Alfred

    2016-07-01

    The Stratospheric Observatory For Infrared Astronomy (SOFIA) reached its full operational capability in 2014 and takes off from the NASA Armstrong Flight Research Center to explore the universe about three times a week. Maximizing the program's scientific output naturally leaves very little flight time for implementation and test of improved soft- and hardware. Consequently, it is very important to have a comparable test environment and infrastructure to perform troubleshooting, verifications and improvements on ground without interfering with science missions. SOFIA's Secondary Mirror Mechanism is one of the most complex systems of the observatory. In 2012 a first simple laboratory mockup of the mechanism was built to perform basic controller tests in the lower frequency band of up to 50Hz. This was a first step to relocate required engineering tests from the active observatory into the laboratory. However, to test and include accurate filters and damping methods as well as to evaluate hardware modifications a more precise mockup is required that represents the system characteristics over a much larger frequency range. Therefore the mockup has been improved in several steps to a full test environment representing the system dynamics with high accuracy. This new ground equipment allows moving almost the entire secondary mirror test activities away from the observatory. As fast actuator in the optical path, the SMM also plays a major role in SOFIA's pointing stabilization concept. To increase the steering bandwidth, hardware changes are required that ultimately need to be evaluated using the telescope optics. One interesting concept presented in this contribution is the in- stallation of piezo stack actuators between the mirror and the chopping mechanism. First successful baseline tests are presented. An outlook is given about upcoming performance tests of the actively controlled piezo stage with local metrology and optical feedback. To minimize the impact on

  15. Ecological requirements for pallid sturgeon reproduction and recruitment in the Missouri River—Annual report 2014

    Science.gov (United States)

    Delonay, Aaron J.; Chojnacki, Kimberly A.; Jacobson, Robert B.; Braaten, Patrick J.; Buhl, Kevin J.; Elliott, Caroline M.; Erwin, Susannah O.; Faulkner, Jacob D.A.; Candrl, James S.; Fuller, David B.; Backes, Kenneth M.; Haddix, Tyler M.; Rugg, Matthew L.; Wesolek, Christopher J.; Eder, Brandon L.; Mestl, Gerald E.

    2016-03-16

    The Comprehensive Sturgeon Research Project is a multiyear, multiagency collaborative research framework developed to provide information to support pallid sturgeon recovery and Missouri River management decisions. The project strategy integrates field and laboratory studies of sturgeon reproductive ecology, early life history, habitat requirements, and physiology. The project scope of work is developed annually with collaborating research partners and in cooperation with the U.S. Army Corps of Engineers, Missouri River Recovery Program–Integrated Science Program. The project research consists of several interdependent and complementary tasks that involve multiple disciplines.The project research tasks in the 2014 scope of work emphasized understanding of reproductive migrations and spawning of adult pallid sturgeon and hatch and drift of larvae. These tasks were addressed in three hydrologically and geomorphologically distinct parts of the Missouri River Basin: the Lower Missouri River downstream from Gavins Point Dam, the Upper Missouri River downstream from Fort Peck Dam and downstream reaches of the Milk River, and the Lower Yellowstone River. The project research is designed to inform management decisions related to channel re-engineering, flow modification, and pallid sturgeon population augmentation on the Missouri River and throughout the range of the species. Research and progress made through this project are reported to the U.S. Army Corps of Engineers annually. This annual report details the research effort and progress made by the Comprehensive Sturgeon Research Project during 2014.

  16. Dendritic nonlinearities reduce network size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model.

    Directory of Open Access Journals (Sweden)

    Athanasia Papoutsi

    2014-07-01

    Full Text Available Technological advances have unraveled the existence of small clusters of co-active neurons in the neocortex. The functional implications of these microcircuits are in large part unexplored. Using a heavily constrained biophysical model of a L5 PFC microcircuit, we recently showed that these structures act as tunable modules of persistent activity, the cellular correlate of working memory. Here, we investigate the mechanisms that underlie persistent activity emergence (ON and termination (OFF and search for the minimum network size required for expressing these states within physiological regimes. We show that (a NMDA-mediated dendritic spikes gate the induction of persistent firing in the microcircuit. (b The minimum network size required for persistent activity induction is inversely proportional to the synaptic drive of each excitatory neuron. (c Relaxation of connectivity and synaptic delay constraints eliminates the gating effect of NMDA spikes, albeit at a cost of much larger networks. (d Persistent activity termination by increased inhibition depends on the strength of the synaptic input and is negatively modulated by dADP. (e Slow synaptic mechanisms and network activity contain predictive information regarding the ability of a given stimulus to turn ON and/or OFF persistent firing in the microcircuit model. Overall, this study zooms out from dendrites to cell assemblies and suggests a tight interaction between dendritic non-linearities and network properties (size/connectivity that may facilitate the short-memory function of the PFC.

  17. Inertia may limit efficiency of slow flapping flight, but mayflies show a strategy for reducing the power requirements of loiter

    Energy Technology Data Exchange (ETDEWEB)

    Usherwood, James R [Structure and Motion Lab., Royal Veterinary College, North Mymms, Hatfield, Herts AL9 7TA (United Kingdom)], E-mail: jusherwood@rvc.ac.uk

    2009-03-01

    Predictions from aerodynamic theory often match biological observations very poorly. Many insects and several bird species habitually hover, frequently flying at low advance ratios. Taking helicopter-based aerodynamic theory, wings functioning predominantly for hovering, even for quite small insects, should operate at low angles of attack. However, insect wings operate at very high angles of attack during hovering; reduction in angle of attack should result in considerable energetic savings. Here, I consider the possibility that selection of kinematics is constrained from being aerodynamically optimal due to the inertial power requirements of flapping. Potential increases in aerodynamic efficiency with lower angles of attack during hovering may be outweighed by increases in inertial power due to the associated increases in flapping frequency. For simple hovering, traditional rotary-winged helicopter-like micro air vehicles would be more efficient than their flapping biomimetic counterparts. However, flapping may confer advantages in terms of top speed and manoeuvrability. If flapping-winged micro air vehicles are required to hover or loiter more efficiently, dragonflies and mayflies suggest biomimetic solutions.

  18. 77 FR 2064 - Availability of the Report on the International Workshop on Alternative Methods To Reduce, Refine...

    Science.gov (United States)

    2012-01-13

    ..., Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing: State of the Science and... Reduce, Refine, and Replace the Use of Animals in Vaccine Potency and Safety Testing: State of the... potential adverse health effects. However, such testing requires large numbers of animals and accounts for...

  19. Changing Arctic Ecosystems: Updated forecast: Reducing carbon dioxide (CO2) emissions required to improve polar bear outlook

    Science.gov (United States)

    Oakley, Karen L.; Atwood, Todd C.; Mugel, Douglas N.; Rode, Karyn D.; Whalen, Mary E.

    2015-01-01

    The Arctic is warming faster than other regions of the world due to the loss of snow and ice, which increases the amount of solar energy absorbed by the region. The most visible consequence has been the rapid decline in sea ice over the last 3 decades-a decline projected to bring long ice-free summers if greenhouse gas (GHG) emissions are not significantly reduced. The polar bear (Ursus maritimus) depends on sea ice over the biologically productive continental shelves of the Arctic Ocean as a platform for hunting seals. In 2008, the U.S. Fish and Wildlife Service listed the polar bear as threatened under the Endangered Species Act (ESA) due to the threat posed by sea ice loss. The polar bear was the first species to be listed due to forecasted population declines from climate change.

  20. Apparent Minimum Free Energy Requirements for Methanogenic Archaea and Sulfate-Reducing Bacteria in an Anoxic Marine Sediment

    Science.gov (United States)

    Hoehler, Tori M.; Alperin, Marc J.; Albert, Daniel B.; Martens, Christopher S.; DeVincenzi, Don (Technical Monitor)

    2000-01-01

    Among the most fundamental constraints governing the distribution of microorganisms in the environment is the availability of chemical energy at biologically useful levels. To assess the minimum free energy yield that can support microbial metabolism in situ, we examined the thermodynamics of H2-consuming processes in anoxic sediments from Cape Lookout Bight, NC, USA. Depth distributions of H2 partial pressure, along with a suite of relevant concentration data, were determined in sediment cores collected in November (at 14.5 C) and August (at 27 C) and used to calculate free energy yields for methanogenesis and sulfate reduction. At both times of year, and for both processes, free energy yields gradually decreased (became less negative) with depth before reaching an apparent asymptote. Sulfate reducing bacteria exhibited an asymptote of -19.1 +/- 1.7 kj(mol SO4(2-)(sup -1) while methanogenic archaea were apparently supported by energy yields as small as -10.6 +/- 0.7 kj(mol CH4)(sup -1).

  1. Child Care: State Efforts To Enforce Safety and Health Requirements. United States General Accounting Office Report to Congressional Requesters.

    Science.gov (United States)

    Fagnoni, Cynthia M.

    Although states must certify that they have requirements to protect the health and safety of children in child care in order to receive Child Care and Development Block Grant funds, neither the scope nor stringency of these requirements has been stipulated. At the request of Congressional members, this report identifies the most critical…

  2. A Simulated Level Loading of Supply and Demand for Beds in a Tertiary Care Children's Hospital Reduces Overall Bed Requirements.

    Science.gov (United States)

    Gangadharan, Sandeep; Belpanno, Brian

    2015-01-01

    Anticipating throughput and allocating resources effectively in children's hospitals have unique challenges relative to adult inpatient centers. The seasonal and daily variation can be difficult to anticipate in terms of impact and creating plans for adequate preparation. Discrete event simulation methodology can be helpful in determining appropriate allocation of resources and has been increasingly appropriated in health care from industry. A representative sample set was abstracted from the Cohen Children's Medical Center census tracking system to describe the present state. A larger data set was used to determine the appropriate level load. The total work performed each hour from 8 AM to 8 PM was evaluated against the level load plan of 11.5%. During the initial hours of the working period when the total work was low, more discharges were added. For each discharge added, an equal quantity of discharges was subtracted from the later hours of the day to bring the total work below 11.5% for each hour. Once the simulated state discharges were determined, a new aggregate bed supply line was created. These values were then added to the original visualization to show improvement. Our analysis suggests that a large part of the discharge/transfer activity and bed demand activity occurs in the pediatric intensive care unit in a roughly 4- to 5-hour window. Our simulation analysis suggests that level loading of this resource-intensive activity period has a potential to reduce bed occupancy, increase bed availability in peak bed demand times, and improve efficiency and throughput throughout the hospital. Discrete event simulation can be an effective tool for pediatric inpatient centers to determine appropriate allocation of resources to enhance patient safety and throughput without significant, costly expansion of bed capacity.

  3. Integrated assessment of acid deposition impacts using reduced-form modeling. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Sinha, R.; Small, M.J.

    1996-05-01

    Emissions of sulfates and other acidic pollutants from anthropogenic sources result in the deposition of these acidic pollutants on the earth`s surface, downwind of the source. These pollutants reach surface waters, including streams and lakes, and acidify them, resulting in a change in the chemical composition of the surface water. Sometimes the water chemistry is sufficiently altered so that the lake can no longer support aquatic life. This document traces the efforts by many researchers to understand and quantify the effect of acid deposition on the water chemistry of populations of lakes, in particular the improvements to the MAGIC (Model of Acidification of Groundwater in Catchments) modeling effort, and describes its reduced-form representation in a decision and uncertainty analysis tool. Previous reduced-form approximations to the MAGIC model are discussed in detail, and their drawbacks are highlighted. An improved reduced-form model for acid neutralizing capacity is presented, which incorporates long-term depletion of the watershed acid neutralization fraction. In addition, improved fish biota models are incorporated in the integrated assessment model, which includes reduced-form models for other physical and chemical processes of acid deposition, as well as the resulting socio-economic and health related effects. The new reduced-form lake chemistry and fish biota models are applied to the Adirondacks region of New York.

  4. Grout to meet physical and chemical requirements for closure at Hanford grout vaults. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1994-07-21

    The US Army Engineer Waterways Experiment Station (WES) developed a grout based on portland cement, Class F fly ash, and bentonite clay, for the Hanford Grout Vault Program. The purpose of this grout was to fill the void between a wasteform containing 106-AN waste and the vault cover blocks. Following a successful grout development program, heat output, volume change, and compressive strength were monitored with time in simulated repository conditions and in full-depth physical models. This research indicated that the cold-cap grout could achieve and maintain adequate volume stability and other required physical properties in the internal environment of a sealed vault. To determine if contact with 106-AN liquid waste would cause chemical deterioration of the cold-cap grout, cured specimens were immersed in simulated waste. Over a period of 21 days at 150 F, specimens increased in mass without significant changes in volume. X-ray diffraction of reacted specimens revealed crystallization of sodium aluminum silicate hydrate. Scanning electron microscopy used with X-ray fluorescence showed that clusters if this phase had formed in grout pores, increasing grout density and decreasing its effective porosity. Physical and chemical tests collectively indicate a sealing component. However, the Hanford Grout Vault Program was cancelled before completion of this research. This report summarizes close-out Waterways Experiment Station when the Program was cancelled.

  5. Report on the COSPAR Workshop on Refining Planetary Protection Requirements for Human Missions

    Science.gov (United States)

    Spry, James Andrew; Rummel, John; Conley, Catharine; Race, Margaret; Kminek, Gerhard; Siegel, Bette

    2016-07-01

    A human mission to Mars has been the driving long-term goal for the development of the Global Exploration Roadmap by the International Space Exploration Coordination Group. Additionally, multiple national space agencies and commercial organizations have published similar plans and aspirations for human missions beyond LEO. The current COSPAR planetary protection "Guidelines for Human Missions to Mars" were developed in a series of workshops in the early 2000s and adopted into COSPAR policy at the Montreal Assembly in 2008. With changes and maturation in mission architecture concepts and hardware capabilities, the holding of a workshop provided an opportunity for timely review of these guidelines and their interpretation within current frameworks provided by ISECG and others. The COSPAR Workshop on Refining Planetary Protection Requirements for Human Missions was held in the US in spring 2016 to evaluate recent efforts and activities in the context of current COSPAR policy, as well as collect inputs from the various organizations considering crewed exploration missions to Mars and precursor robotic missions focused on surface material properties and environmental challenges. The workshop also considered potential updates to the COSPAR policy for human missions across a range of planetary destinations. This paper will report on those deliberations.

  6. Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis

    OpenAIRE

    Meng Wang; Xin-Feng Zheng; Lei-Sheng Jiang

    2015-01-01

    Background Routine use of antifibrinolytic agents in spine surgery is still an issue of debate. Objective To gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA) and epsilon aminocaproic acid (EACA, traditionally known as Amicar) in reducing perioperative blood loss and transfusion requirements in scoliosis surgery. Methods We conducted a systematic review and meta-analysis for randomized controlled trials (RCTs), retrosp...

  7. 45 CFR 265.7 - How will we determine if the State is meeting the quarterly reporting requirements?

    Science.gov (United States)

    2010-10-01

    ... OFFICE OF FAMILY ASSISTANCE (ASSISTANCE PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT... reports data for all required elements (i.e., no data are missing); (4)(i) The State provides data on all families; or (ii) If the State opts to use sampling, the State reports data on all families selected in...

  8. 41 CFR 102-74.200 - What information are Federal agencies required to report to the Department of Energy (DOE)?

    Science.gov (United States)

    2010-07-01

    ...)? Federal agencies, upon approval of GSA, must report to the DOE the energy consumption in buildings... Federal agencies required to report to the Department of Energy (DOE)? 102-74.200 Section 102-74.200...) FEDERAL MANAGEMENT REGULATION REAL PROPERTY 74-FACILITY MANAGEMENT Facility Management Energy...

  9. 22 CFR 99.2 - Reporting requirements for adoption cases involving children emigrating from the United States.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Reporting requirements for adoption cases involving children emigrating from the United States. 99.2 Section 99.2 Foreign Relations DEPARTMENT OF... Convention case, or in a non-Convention case, the reporting provider is the agency, person, public...

  10. 20 CFR 1010.320 - Will recipients be required to collect information and report on priority of service?

    Science.gov (United States)

    2010-04-01

    ... to collect information and report on priority of service? Yes. Every recipient of funds for qualified job training programs must collect such information, maintain such records, and submit reports... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Will recipients be required to...

  11. Reducing barriers to energy efficiency in the German brewing sector. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Schleich, J.; Boede, U.; Ostertag, K.; Radgen, P.

    2000-12-01

    This report describes the empirical research into barriers to energy efficiency in the German brewing sector. It is one of nine such reports in the BARRIERS project. The report contains description and analysis of five case studies of energy management in German breweries. The results are analysed using the theoretical framework developed for the BARRIERS project. The report also provides brief recommendations on how these barriers to the rational use of energy (RUE) may be overcome and how energy efficiency within the brewing sector may be improved. The results of the study for the brewing sector in Germany are summarised in this executive summary under the following headings: - Characterising the brewing sector - Case studies of energy management in the German brewing sector; - Evidence of barriers in the German brewing sector; - The role of energy service companies in the brewing sector; - Policy implications. (orig.)

  12. Reducing barriers to energy efficiency in the German mechanical engineering sector. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Schleich, J.; Boede, U.

    2000-12-01

    This report describes the empirical research into barriers to energy efficiency in the German mechanical engineering (ME) sector. It is one of nine such reports in the BARRIERS project. The report contains description and analysis of four case studies of energy management in German companies in the ME sector. The results are analysed using the theoretical framework developed for the BARRIERS project. The report also provides brief recommendations on how these barriers to the rational use of energy (RUE) may be overcome and how energy efficiency within the ME sector may be improved. The results of the study for the ME sector in Germany are summarised in this executive summary under the following headings: - Characterising the mechanical engineering sector; - Case studies of energy management in the German mechanical engineering sector; - Evidence of barriers in the German mechanical engineering sector; - The role of energy service companies in the mechanical engineering sector; - Policy implications. (orig.)

  13. Reducing barriers to energy efficiency in the German higher education sector. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Schleich, J.; Boede, U.

    2000-12-01

    This report describes the empirical research into barriers to energy efficiency in the German higher education (HE) sector. It is one of nine such reports in the BARRIERS project. The report contains description and analysis of six case studies of energy management in German universities. The results are analysed using the theoretical framework developed for the BARRIERS project (Sorrell et al., 2000). The report also provides brief recommendations on how these barriers to the rational use of energy (RUE) may be overcome and how energy efficiency within the sector may be improved. The results of the study for the higher education sector in Germany are summarised in this executive summary under the following headings: - Characterising the higher education sector; - Case studies of energy management in the German higher education sector; - Evidence of barriers in the German higher education sector; - The role of energy service companies in the higher education sector; - Policy implications. (orig.)

  14. 78 FR 13756 - Technical Report: Effectiveness of LED Stop Lamps for Reducing Rear-End Crashes: Analyses of...

    Science.gov (United States)

    2013-02-28

    ... Reducing Rear-End Crashes: Analyses of State Crash Data AGENCY: National Highway Traffic Safety... State Crash Data. DATES: Comments must be received no later than June 28, 2013. ADDRESSES: Report: The...) using real-world crash data. Previous work on this subject included laboratory experiments that...

  15. ASC Computational Environment (ACE) requirements version 8.0 final report.

    Energy Technology Data Exchange (ETDEWEB)

    Larzelere, Alex R. (Exagrid Engineering, Alexandria, VA); Sturtevant, Judith E.

    2006-11-01

    A decision was made early in the Tri-Lab Usage Model process, that the collection of the user requirements be separated from the document describing capabilities of the user environment. The purpose in developing the requirements as a separate document was to allow the requirements to take on a higher-level view of user requirements for ASC platforms in general. In other words, a separate ASC user requirement document could capture requirements in a way that was not focused on ''how'' the requirements would be fulfilled. The intent of doing this was to create a set of user requirements that were not linked to any particular computational platform. The idea was that user requirements would endure from one ASC platform user environment to another. The hope was that capturing the requirements in this way would assist in creating stable user environments even though the particular platforms would be evolving and changing. In order to clearly make the separation, the Tri-lab S&CS program decided to create a new title for the requirements. The user requirements became known as the ASC Computational Environment (ACE) Requirements.

  16. Reducing the Threat of Nuclear Terrorism- A Report Card on the Obama Administration’s Efforts

    Science.gov (United States)

    2016-12-01

    architecture . While some states, such as Japan , South Korea, Pakistan, and India, may have conflicting energy, security, and economic interests that...nonproliferation architecture . The president’s integrative approach wove nonproliferation efforts together that had, traditionally, not been used to reduce...President Obama diligently supported nonproliferation measures by enhancing the domestic and international nonproliferation architecture . The

  17. Reducing Stress within the Rehabilitative Work Setting - A Report on the ROSE Project

    Science.gov (United States)

    Wells, John S. G.; Denny, Margaret

    Reducing Occupational Stress in Employment (ROSE) is an EU funded project which aims to develop a combined person and work directed stress management programme in order to improve the long-term retention of staff in the vocational rehabilitation sector for mental health and intellectual disabilities.

  18. 78 FR 79650 - Definitions and Reporting Requirements for Shareholders of Passive Foreign Investment Companies

    Science.gov (United States)

    2013-12-31

    ... Shareholders of Passive Foreign Investment Companies AGENCY: Internal Revenue Service (IRS), Treasury. ACTION... of a passive foreign investment company (PFIC), the annual filing requirements for shareholders of PFICs, and an exclusion from certain filing requirement for shareholders that constructively...

  19. [Method for direct generation data for formatted case report forms based on requirement for data authenticity in actual clinical conditions].

    Science.gov (United States)

    Shao, Ming-Yi; Liu, Bao-Yan; He, Li-Yun; Zhang, Run-Shun

    2013-04-01

    Data authenticity is the basic requirement of clinical studies. In actual clinical conditions how to establish formatted case report forms (CRF) in line with the requirement for data authenticity is the key to ensure clinical data quality. On the basis of the characteristics of clinical data in actual clinical conditions, we determined elements for establishing formatted case report forms by comparing differences in data characteristics of CRFs in traditional clinical studies and in actual clinical conditions, and then generated formatted case report forms in line with the requirement for data authenticity in actual clinical conditions. The data of formatted CRFs generated in this study could not only meet the requirement for data authenticity of clinical studies in actual clinical conditions, but also comply with data management practices for clinical studies, thus it is deemed as a progress in technical methods.

  20. Global Combat Support System - Army Did Not Comply With Treasury and DoD Financial Reporting Requirements

    Science.gov (United States)

    2014-09-03

    No. DODIG-2014-104 S E P T E M B E R 3 , 2 0 1 4 Global Combat Support System–Army Did Not Comply With Treasury and DoD Financial Reporting...Comply With Treasury and DoD Financial Reporting Requirements 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...i Results in Brief Global Combat Support System–Army Did Not Comply With Treasury and DoD Financial Reporting Requirements Visit us at

  1. Introducing radiology report checklists among residents: adherence rates when suggesting versus requiring their use and early experience in improving accuracy.

    Science.gov (United States)

    Powell, Daniel K; Lin, Eaton; Silberzweig, James E; Kagetsu, Nolan J

    2014-03-01

    To retrospectively compare resident adherence to checklist-style structured reporting for maxillofacial computed tomography (CT) from the emergency department (when required vs. suggested between two programs). To compare radiology resident reporting accuracy before and after introduction of the structured report and assess its ability to decrease the rate of undetected pathology. We introduced a reporting checklist for maxillofacial CT into our dictation software without specific training, requiring it at one program and suggesting it at another. We quantified usage among residents and compared reporting accuracy, before and after counting and categorizing faculty addenda. There was no significant change in resident accuracy in the first few months, with residents acting as their own controls (directly comparing performance with and without the checklist). Adherence to the checklist at program A (where it originated and was required) was 85% of reports compared to 9% of reports at program B (where it was suggested). When using program B as a secondary control, there was no significant difference in resident accuracy with or without using the checklist (comparing different residents using the checklist to those not using the checklist). Our results suggest that there is no automatic value of checklists for improving radiology resident reporting accuracy. They also suggest the importance of focused training, checklist flexibility, and a period of adjustment to a new reporting style. Mandatory checklists were readily adopted by residents but not when simply suggested. Copyright © 2014 AUR. Published by Elsevier Inc. All rights reserved.

  2. Reducing barriers to energy efficiency in the German energy service companies sector. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Koewener, D.; Schleich, J.

    2000-12-01

    This report describes the empirical research conducted in the German energy service sector to assess to what extent energy service companies (ESCOs) can help overcome the barriers to energy in the higher education, brewing and mechanical engineering sectors. This report complements the sector for Germany within the BARRIERS project (Sorrell et al., 2000; Schleich/Boede 2000a; Schleich/Boede 2000b; Schleich et al., 2000). The report characterises the German energy service sector, contains a description and analysis of four case studies in the energy service sector, identifies the main barriers and chances for ESCOs in the higher education, brewery and mechanical engineering sectors, and concludes with brief recommendations on how these barriers may be overcome. The results of the study are summarised here under the following headings: Characterising the energy service sector in Germany; - Case studies of energy service companies in Germany; - The role of ESCOs in the case-study sectors; - Policy implications. (orig.)

  3. Root abnormalities, talon cusps, dentes invaginati with reduced alveolar bone levels: case report.

    LENUS (Irish Health Repository)

    McNamara, C M

    1998-03-01

    This is a case report of a Caucasian female who presented with an unusual combination of dental anomalies: short roots on the maxillary central incisors and premolars, talon cusps, dentes invaginati, low alveolar bone heights, tubercles of Carabelli on the maxillary first and second permanent molars, with pyramidal root morphology in three of the second permanent molars. None of the anomalies alone are particularly uncommon but they have not previously been reported together. The occurrence of the anomalies is probably incidental as the conditions are aetiologically unrelated.

  4. Reducing the carbon footprint of the operating theatre: a multicentre quality improvement report.

    Science.gov (United States)

    Southorn, T; Norrish, A R; Gardner, K; Baxandall, R

    2013-06-01

    Currently, there are very few provisions for recycling in theatres. We measured the weight of clinical waste for several orthopaedic operations. This waste was then examined and sorted into domestic waste and clinical waste. With staff education it is possible to reduce the amount of clinical waste generated by the operating theatre by roughly 50%. A greater awareness of disposal options leads to a reduction in waste disposed of by incineration.

  5. Reduced processing speed in rugby union players reporting three or more previous concussions.

    Science.gov (United States)

    Gardner, Andrew; Shores, E Arthur; Batchelor, Jennifer

    2010-05-01

    The issue pertaining to the effect of multiple self-reported sports-related concussions on cognitive function is controversial. Although this topic has received increased attention in the literature recently, the issue remains unresolved. Evidence supporting a detrimental cognitive effect has been reported at a sub-concussive level and following one, two, and three or more previous concussions. However, numerous studies have been unable to replicate these findings. Additionally, discrepancies between neuropsychological testing formats have been identified, where studies utilizing traditional tests tend to support the notion of detrimental cognitive effects whereas studies with computerized tests have tended to demonstrate no effect. The present study sought to examine possible detrimental cognitive effects in a sample of adult male rugby union players who reported a history of three or more concussions (n = 34) compared with those who reported no previous concussions (n = 39). A computerized neuropsychological battery and a traditional neuropsychological measure of processing speed were administered for this purpose. Findings revealed that there were differences between groups on two processing speed measures from both traditional and computerized tests. Athletes with a history of multiple concussions performed significantly lower on these measures than those with no history of concussion. These results provide further evidence to suggest that a history of three or more self-reported concussions in active athletes may have a detrimental effect on cognitive function. Future research may focus on identifying moderating factors in an attempt to resolve some of the conflicting findings and identify potential athletes at risk for sustaining cognitive deficits.

  6. Actions taken to reduce sodium intake among adults with self-reported hypertension: HealthStyles survey, 2005 and 2008.

    Science.gov (United States)

    Ayala, Carma; Tong, Xin; Valderrama, Amy; Ivy, Andrae; Keenan, Nora

    2010-10-01

    Consuming high amounts of dietary sodium is associated with hypertension. The authors analyzed the HealthStyles 2005 and 2008 survey for behaviors to lower blood pressure related to dietary sodium, including the reduction of sodium intake and reading food labels for sodium content among hypertensives. All estimates were based on self-reported data. The relative percent change (RPC) in the prevalence of these behaviors between 2005 and 2008 was assessed. During the 3-year period, there were increases in the prevalence of reducing dietary sodium (RPC=17.2%, 56.6% in 2008 vs 48.3% in 2005; P<.05) and reading food labels for sodium content (RPC=7.9%, 53.0% vs 49.1%; P<.05). In 2005, the proportion of hypertensive adults who reported reducing dietary sodium was higher for persons 65 years and older, for blacks, for those with income <$25,000, and for those with more than a high school education compared with those in their comparison groups. In 2008, those aged 65 years and older had the highest percentage, while Hispanics and blacks had essentially the same percentage for reducing sodium. Based on 2005 and 2008 HealthStyles surveys, about half of hypertensive patients reported reducing their intake of sodium and reading food labels for salt. Health care providers should emphasize the importance of knowing the daily recommended limit for dietary sodium to help adults lower this intake.

  7. Two to five repeated measurements per patient reduced the required sample size considerably in a randomized clinical trial for patients with inflammatory rheumatic diseases

    OpenAIRE

    Smedslund Geir; Zangi Heidi Andersen; Mowinckel Petter; Hagen Kåre Birger

    2013-01-01

    Abstract Background Patient reported outcomes are accepted as important outcome measures in rheumatology. The fluctuating symptoms in patients with rheumatic diseases have serious implications for sample size in clinical trials. We estimated the effects of measuring the outcome 1-5 times on the sample size required in a two-armed trial. Findings In a randomized controlled trial that evaluated the effects of a mindfulness-based group intervention for patients with inflammatory arthritis (n=71)...

  8. The potential of low-power laser for reducing dental sensitivity after in-office bleaching: a case report.

    Science.gov (United States)

    Mayer-Santos, Eric; Anhesini, Brunna Haddad; Shimokawa, Carlos Alberto Kenji; Aranha, Ana Cecília Corrêa; Eduardo, Carlos Paula; de Freitas, Patricia Moreira

    2017-01-01

    Postoperative sensitivity is one of the most common side effects of in-office bleaching with hydrogen peroxide. Laser phototherapy (LPT) has been suggested as an adjunctive treatment to prevent or minimize tooth sensitivity. This case report aimed to verify the efficacy of LPT in the reduction of sensitivity after in-office bleaching. Tooth bleaching was performed with 35% hydrogen peroxide activated with a hybrid LED-laser device. Immediately after the bleaching treatment, the patient reported dental sensitivity, as measured with a visual analog scale (VAS). To reduce sensitivity, LPT was applied with a 780-nm laser using the following parameters: 70 mW, exposure time of 10 seconds per point of irradiation (middle region of the buccal surfaces of each compromised tooth) in contact mode, energy of 1 J per point. Immediately after LPT, the patient reported a substantially lower level of pain on the VAS. Twenty-four hours after bleaching, the score on the VAS indicated that sensitivity levels had rebounded, and the patient received additional LPT. After 48 hours, the patient reported no dental sensitivity. The results in this patient indicated that irradiation with an infrared low-power laser substantially reduced dental pain generated by bleaching, suggesting that LPT should be considered as an auxiliary method to reduce postbleaching tooth sensitivity.

  9. Cost optimal building performance requirements. Calculation methodology for reporting on national energy performance requirements on the basis of cost optimality within the framework of the EPBD

    Energy Technology Data Exchange (ETDEWEB)

    Boermans, T.; Bettgenhaeuser, K.; Hermelink, A.; Schimschar, S. [Ecofys, Utrecht (Netherlands)

    2011-05-15

    On the European level, the principles for the requirements for the energy performance of buildings are set by the Energy Performance of Buildings Directive (EPBD). Dating from December 2002, the EPBD has set a common framework from which the individual Member States in the EU developed or adapted their individual national regulations. The EPBD in 2008 and 2009 underwent a recast procedure, with final political agreement having been reached in November 2009. The new Directive was then formally adopted on May 19, 2010. Among other clarifications and new provisions, the EPBD recast introduces a benchmarking mechanism for national energy performance requirements for the purpose of determining cost-optimal levels to be used by Member States for comparing and setting these requirements. The previous EPBD set out a general framework to assess the energy performance of buildings and required Member States to define maximum values for energy delivered to meet the energy demand associated with the standardised use of the building. However it did not contain requirements or guidance related to the ambition level of such requirements. As a consequence, building regulations in the various Member States have been developed by the use of different approaches (influenced by different building traditions, political processes and individual market conditions) and resulted in different ambition levels where in many cases cost optimality principles could justify higher ambitions. The EPBD recast now requests that Member States shall ensure that minimum energy performance requirements for buildings are set 'with a view to achieving cost-optimal levels'. The cost optimum level shall be calculated in accordance with a comparative methodology. The objective of this report is to contribute to the ongoing discussion in Europe around the details of such a methodology by describing possible details on how to calculate cost optimal levels and pointing towards important factors and

  10. Requirements and standards facilitating quality improvement for reporting systems in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.

    Science.gov (United States)

    Bretthauer, Michael; Aabakken, Lars; Dekker, Evelien; Kaminski, Michal F; Rösch, Thomas; Hultcrantz, Rolf; Suchanek, Stepan; Jover, Rodrigo; Kuipers, Ernst J; Bisschops, Raf; Spada, Cristiano; Valori, Roland; Domagk, Dirk; Rees, Colin; Rutter, Matthew D

    2016-03-01

    To develop standards for high quality in gastrointestinal (GI) endoscopy, the European Society of Gastrointestinal Endoscopy (ESGE) has established the ESGE Quality Improvement Committee. A prerequisite for quality assurance and improvement for all GI endoscopy procedures is state-of-the-art integrated digital reporting systems for standardized documentation of the procedures. The current paper describes the ESGE's viewpoints on the requirements for high-quality endoscopy reporting systems in GI endoscopy. Recommendations 1 Endoscopy reporting systems must be electronic. 2 Endoscopy reporting systems should be integrated into hospitals' patient record systems. 3 Endoscopy reporting systems should include patient identifiers to facilitate data linkage to other data sources. 4 Endoscopy reporting systems shall restrict the use of free-text entry to a minimum, and be based mainly on structured data entry. 5 Separate entry of data for quality or research purposes is discouraged. Automatic data transfer for quality and research purposes must be facilitated. 6 Double entry of data by the endoscopist or associate personnel is discouraged. Available data from outside sources (administrative or medical) must be made available automatically. 7 Endoscopy reporting systems shall facilitate the inclusion of information on histopathology of detected lesions, patient satisfaction, adverse events, and surveillance recommendations. 8 Endoscopy reporting systems must facilitate easy data retrieval at any time in a universally compatible format. 9 Endoscopy reporting systems must include data fields for key performance indicators as defined by quality improvement committees. 10 Endoscopy reporting systems must facilitate changes in indicators and data entry fields as required by professional organizations.

  11. Reporting systems in gastrointestinal endoscopy: Requirements and standards facilitating quality improvement: European Society of Gastrointestinal Endoscopy position statement.

    Science.gov (United States)

    Bretthauer, Michael; Aabakken, Lars; Dekker, Evelien; Kaminski, Michal F; Rösch, Thomas; Hultcrantz, Rolf; Suchanek, Stepan; Jover, Rodrigo; Kuipers, Ernst J; Bisschops, Raf; Spada, Cristiano; Valori, Roland; Domagk, Dirk; Rees, Colin; Rutter, Matthew D

    2016-04-01

    To develop standards for high quality of gastrointestinal endoscopy, the European Society of Gastrointestinal Endoscopy (ESGE) has established the ESGE Quality Improvement Committee. A prerequisite for quality assurance and improvement for all gastrointestinal endoscopy procedures is state-of-the-art integrated digital reporting systems for standardized documentation of the procedures. The current paper describes the ESGE's viewpoints on requirements for high-quality endoscopy reporting systems. The following recommendations are issued: Endoscopy reporting systems must be electronic.Endoscopy reporting systems should be integrated into hospital patient record systems.Endoscopy reporting systems should include patient identifiers to facilitate data linkage to other data sources.Endoscopy reporting systems shall restrict the use of free text entry to a minimum, and be based mainly on structured data entry.Separate entry of data for quality or research purposes is discouraged. Automatic data transfer for quality and research purposes must be facilitated.Double entry of data by the endoscopist or associate personnel is discouraged. Available data from outside sources (administrative or medical) must be made available automatically.Endoscopy reporting systems shall enable the inclusion of information on histopathology of detected lesions; patient's satisfaction; adverse events; surveillance recommendations.Endoscopy reporting systems must facilitate easy data retrieval at any time in a universally compatible format.Endoscopy reporting systems must include data fields for key performance indicators as defined by quality improvement committees.Endoscopy reporting systems must facilitate changes in indicators and data entry fields as required by professional organizations.

  12. 76 FR 47211 - Report on the Performance of Drug and Biologics Firms in Conducting Postmarketing Requirements...

    Science.gov (United States)

    2011-08-04

    ..., clinical efficacy, clinical pharmacology, and nonclinical toxicology study/clinical trial either required... consolidation of certain therapeutic products formerly regulated by CBER into CDER. Consequently, CDER...

  13. Women With Addictions Report Reduced Anxiety After Group Music Therapy: A Quasi-Experimental Study

    Directory of Open Access Journals (Sweden)

    Wiebke S. Diestelkamp

    2013-07-01

    Full Text Available Roughly six million females in the USA abuse or are addicted to alcohol. Women are more likely than men to report depression and anxiety as triggers for substance use and relapse, which emphasizes the importance of therapies designed to help women mitigate anxiety.Research supporting music therapy (MT with women with addictions is scarce. In this quasi-experimental investigation, we hoped to learn: (1 What percentage of women with addictive disorders in a 45-minute group MT session will report pre-session anxiety?; and (2 of these, what percentage will report a palpable reduction in their post-session anxiety? We used a single group design: Participants self-reported anxiety before and after each session.Study participants were 53 women in a gender-specific residential program. Voluntary group MT sessions were held twice weekly for 9 weeks. Four MT methods were used: Composition, Receptive (Listening, Improvisation, and Re-Creative (Performing. Of 53 first-session surveys, 39 (73.6% indicated pre-session anxiety. Of these, 33 (84.6% showed a reduction in post-session anxiety. A sign test confirmed an overall reduction in anxiety.Outcomes may have been related to interventions, group cohesion, or other factors. The absence of a comparison group prevents suppositions of causality. Nonetheless, the results present a compelling case for the use of MT with women with anxiety. Because of the link between trauma and addictive disorders, we encourage exploration of the role and benefits of MT within trauma-informed models of addiction treatment.

  14. Women With Addictions Report Reduced Anxiety After Group Music Therapy: A Quasi-Experimental Study

    OpenAIRE

    Diestelkamp, Wiebke S.; Susan C. Gardstrom

    2013-01-01

    Roughly six million females in the USA abuse or are addicted to alcohol. Women are more likely than men to report depression and anxiety as triggers for substance use and relapse, which emphasizes the importance of therapies designed to help women mitigate anxiety.Research supporting music therapy (MT) with women with addictions is scarce. In this quasi-experimental investigation, we hoped to learn: (1) What percentage of women with addictive disorders in a 45-minute group MT session will rep...

  15. Medicare program; Home Health Prospective Payment System rate update for calendar year 2013, hospice quality reporting requirements, and survey and enforcement requirements for home health agencies. Final rule.

    Science.gov (United States)

    2012-11-08

    This final rule updates the Home Health Prospective Payment System (HH PPS) rates, including the national standardized 60-day episode rates, the national per-visit rates, the low-utilization payment amount (LUPA), the non-routine medical supplies (NRS) conversion factor, and outlier payments under the Medicare prospective payment system for home health agencies effective January 1, 2013. This rule also establishes requirements for the Home Health and Hospice quality reporting programs. This final rule will also establish requirements for unannounced, standard and extended surveys of home health agencies (HHAs) and sets forth alternative sanctions that could be imposed instead of, or in addition to, termination of the HHA's participation in the Medicare program, which could remain in effect up to a maximum of 6 months, until an HHA achieves compliance with the HHA Conditions of Participation (CoPs) or until the HHA's provider agreement is terminated.

  16. 76 FR 30238 - Reports, Forms, and Recordkeeping Requirements Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2011-05-24

    ... information from state level reporting entities that can be used to measure the progress of 9-1-1 authorities... proposed effort, NHTSA would specifically request reporting entities to voluntarily collect and annually... reporting entity, for a total of 168 hours for all entities. The respondents would not incur any...

  17. Emissions Inventory Report Summary: Reporting Requirements for the New Mexico Administrative Code, Title 20, Chapter 2, Part 73 (20 NMAC 2.73) for Calendar Year 2001

    Energy Technology Data Exchange (ETDEWEB)

    Margorie Stockton

    2003-04-01

    Los Alamos National Laboratory is subject to annual emissions-reporting requirements for regulated air contaminants under Title 20 of the New Mexico Administrative Code, Chapter 2, Part 73 (20.2.73 NMAC), Notice of Intent and Emissions Inventory Requirements. The applicability of the requirements is based on the Laboratory's potential to emit 100 tons per year of suspended particulate matter, nitrogen oxides, carbon monoxide, sulfur oxides, or volatile organic compounds. For calendar year 2001, the Technical Area 3 steam plant was the primary source of criteria air pollutants from the Laboratory, while research and development activities were the primary source of volatile organic compounds. Emissions of beryllium and aluminum were reported for activities permitted under 20.2.72 NMAC. Hazardous air pollutant emissions from chemical use for research and development activities were also reported.

  18. 50 CFR 18.128 - What are the mitigation, monitoring, and reporting requirements?

    Science.gov (United States)

    2010-10-01

    ... require a monitor on the site of the activity or on board drill ships, drill rigs, aircraft, icebreakers... or require that the operator conduct activities after the female bears emerge from their dens. We... Alaska Regional Director (Attn: Marine Mammals Management Office) within 90 days after completion...

  19. 40 CFR 75.74 - Annual and ozone season monitoring and reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... every five years and is also required if the flow monitor polynomial coefficients or K factor(s) are...-diluent monitoring system, each flow rate monitoring system, each moisture monitoring system and each... not apply, and, for flow rate monitoring systems, the required RATA load level(s) (or operating level...

  20. 75 FR 16895 - Reports, Forms and Record Keeping Requirements; Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2010-04-02

    ...) abstracted below has been forwarded to the Office of Management and Budget (OMB) for review and comment. The... days to the Office of Information and Regulatory Affairs, Office of Management and Budget, 725 17th... requirement in Part 575 which would require tire manufacturers and tire brand name owners to rate...

  1. Digital Avionics Information System (DAIS): Training Requirements Analysis Model Users Guide. Final Report.

    Science.gov (United States)

    Czuchry, Andrew J.; And Others

    This user's guide describes the functions, logical operations and subroutines, input data requirements, and available outputs of the Training Requirements Analysis Model (TRAMOD), a computerized analytical life cycle cost modeling system for use in the early stages of system design. Operable in a stand-alone mode, TRAMOD can be used for the…

  2. MORE. Management of Requirements in NPP modernisation projects - Project report 2005

    Energy Technology Data Exchange (ETDEWEB)

    Thunem, A.P.J.; Fredriksen, R.; Thunem, H.P.J. [IFE (Norway); Ventae, O.; Valkonen, J.; Holmberg, J.E. [VTT Technical Research Centre of Finland (Finland)

    2006-04-15

    The overall objective of the project MORE is to improve the means for managing the large amounts of evolving requirements in Nordic NPP modernisation projects. In accordance to this objective, the activity will facilitate the industrial utilisation of the research results from the project TACO. On the basis of experiences in the Nordic countries, the overall aim of the TACO project has been to identify the best practices and most important criteria for ensuring effective communication in relation to requirements elicitation and analysis, understandability of requirements to all parties, and traceability of requirements. The project resulted in the development of a traceability model for handling requirements from their origins and through their final shapes. Particular emphasis for the MORE project in 2005 was put on utilising a prototype of a tool (TRACE) intended to support an adopted approach to dependable requirements engineering, suitable for modelling and handling large amounts of requirements related to all stages of the systems development process and not only those traditionally including requirements at high-level stages. (au)

  3. Reiki brief report: using Reiki to reduce stress levels in a nine-year-old child.

    Science.gov (United States)

    Bukowski, Elaine L; Berardi, Diana

    2014-01-01

    A nine-year-old female with a history of perinatal stroke, seizures, and type-I diabetes was seen for six weeks of Reiki to determine the effects of Reiki on relaxation, and in turn, the prevention of future seizures. The secondary and tertiary aims were to determine the effects of Reiki on sleep patterns and the stress levels of the mother. There was a decrease in stress in both the child and the mother, as measured by a modified Perceived Stress Scale and a Perceived Stress Scale, respectively. There was no change in the child's overall sense of well-being, as measured by a global questionnaire. There was a positive change in sleep patterns on 33.3% of the nights during which the study occurred, as reported on a sleep log kept by the mother. The child and the Reiki Master (a Reiki practitioner who has completed all three levels of Reiki certification training and trains and certifies individuals in the practice of Reiki as well as provides Reiki to individuals) experienced warmth and tingling sensations on the same area of the child during the Reiki sessions. The child relaxed within the first five to seven minutes of each session as reported by the Reiki Master. There were no reports of seizures during this study. Reiki may be a useful adjunct for children with increased stress levels and sleep disturbances secondary to their medical condition. Further research is warranted to evaluate the use of Reiki in children, particularly with a large sample size, and to evaluate the long-term use of Reiki and its effects on adequate sleep.

  4. Reduced Quadriceps Motor-Evoked Potentials in an Individual with Unilateral Knee Osteoarthritis: A Case Report

    Directory of Open Access Journals (Sweden)

    Michael A. Hunt

    2011-01-01

    Full Text Available One male with unilateral osteoarthritis (OA of the knee underwent testing of corticospinal (CS excitability (as quantified from motor-evoked potentials (MEPs in the rectus femoris (RF using transcranial magnetic stimulation and quadriceps muscle strength. Baseline data indicated reduced MEP amplitudes in the RF of the affected limb compared to the unaffected limb. Increases in RF MEP amplitudes from both limbs were observed immediately following a 30-minute exercise session focusing on muscle strengthening. Following an 8-week muscle strengthening intervention, the participant exhibited increased MEP amplitudes and muscle strength in the affected limb. These findings suggest that alterations in peripheral muscle function found in patients with knee OA may have an origin centrally within the motor cortex and that interlimb differences may be evident in those with unilateral disease. These findings also suggest that CS excitability may be improved following a muscle strengthening intervention.

  5. Reduced anesthetic requirements in aged rats: association with altered brain synaptic plasma membrane Ca(2+)-ATPase pump and phospholipid methyltransferase I activities.

    Science.gov (United States)

    Horn, J L; Janicki, P K; Singh, G; Wamil, A W; Franks, J J

    1996-01-01

    Aging is associated with a decrease in anesthetic requirements. Animal models of aging manifest alteration of brain Ca2+ homeostasis and increased methyltransferase I (PLMTI) activity. In this study we evaluated concurrently anesthetic requirements and brain plasma membrane Ca(2+)-ATPase (PMCA) and PLMTI activities in young and aged rats. Halothane, desflurane, isoflurane and xenon MEDs (lowest partial pressures that suppress a pain response) were measured in 2 and 25 month old, male Fisher-344 rats. Halothane MED was also measured in 2 and 30 month old F344/BNF1 rats, a strain that undergoes aging with less debilitation. PMCA pumping and PLMTI activities were measured in synaptic plasma membranes (SPM) prepared from the cortex and diencephalon-mesencephalon (DM). For aged Fisher-344 rats, MEDs for halothane, desflurane, isoflurane and xenon were reduced to 81%, 82%, 67% and 86%, respectively, of young controls; PMCA activity was diminished to 91% in cortical SPM and 82% in DM SPM; and cortical and DM PLMTI activities were increased to 131% and 114% of young control. For F344/BNF1 rats, MED for halothane was reduced to 87%, PMCA activity was diminished to 90% in cortical SPM and 72% DM SPM, and PLMTI activity was increased to 133% in cortical SPM and 112% in DM SPM. The strong association between age and reduced anesthetic requirements for inhalational agents on the one hand and altered PMCA and PLMTI activity on the other lends support to the underlying hypothesis that PMCA and PLMTI may be involved in the production of the anesthetic state.

  6. Exploiting Electrocorticographic Spectral Characteristics for Optimized Signal Chain Design: A 1.08 Analog Front End With Reduced ADC Resolution Requirements.

    Science.gov (United States)

    Smith, William A; Mogen, Brian J; Fetz, Eberhard E; Sathe, Visvesh S; Otis, Brian P

    2016-12-01

    Electrocorticography (ECoG) is an important area of research for Brain-Computer Interface (BCI) development. ECoG, along with some other biopotentials, has spectral characteristics that can be exploited for more optimal front-end performance than is achievable with conventional techniques. This paper optimizes noise performance of such a system and discusses an equalization technique that reduces the analog-to-digital converter (ADC) dynamic range requirements and eliminates the need for a variable gain amplifier (VGA). We demonstrate a fabricated prototype in 1p9m 65 nm CMOS that takes advantage of the presented findings to achieve high-fidelity, full-spectrum ECoG recording. It requires 1.08 μW over a 150 Hz bandwidth for the entire analog front end and only 7 bits of ADC resolution.

  7. 75 FR 74935 - Rescission of Form T-1, Trust Annual Report; Requiring Subsidiary Organization Reporting on the...

    Science.gov (United States)

    2010-12-01

    ... test failed to establish reporting based on domination or managerial control of assets subject to LMRDA... finances under the LMRDA. The Department has concluded that the 2008 Form T-1 rule is overly broad in... principles. The NPRM also proposed to revise the Form LM-3 subsidiary organization instructions to conform...

  8. What are the greenhouse gas observing system requirements for reducing fundamental biogeochemical process uncertainty? Amazon wetland CH4 emissions as a case study

    Science.gov (United States)

    Bloom, A. Anthony; Lauvaux, Thomas; Worden, John; Yadav, Vineet; Duren, Riley; Sander, Stanley P.; Schimel, David S.

    2016-12-01

    Understanding the processes controlling terrestrial carbon fluxes is one of the grand challenges of climate science. Carbon cycle process controls are readily studied at local scales, but integrating local knowledge across extremely heterogeneous biota, landforms and climate space has proven to be extraordinarily challenging. Consequently, top-down or integral flux constraints at process-relevant scales are essential to reducing process uncertainty. Future satellite-based estimates of greenhouse gas fluxes - such as CO2 and CH4 - could potentially provide the constraints needed to resolve biogeochemical process controls at the required scales. Our analysis is focused on Amazon wetland CH4 emissions, which amount to a scientifically crucial and methodologically challenging case study. We quantitatively derive the observing system (OS) requirements for testing wetland CH4 emission hypotheses at a process-relevant scale. To distinguish between hypothesized hydrological and carbon controls on Amazon wetland CH4 production, a satellite mission will need to resolve monthly CH4 fluxes at a ˜ 333 km resolution and with a ≤ 10 mg CH4 m-2 day-1 flux precision. We simulate a range of low-earth orbit (LEO) and geostationary orbit (GEO) CH4 OS configurations to evaluate the ability of these approaches to meet the CH4 flux requirements. Conventional LEO and GEO missions resolve monthly ˜ 333 km Amazon wetland fluxes at a 17.0 and 2.7 mg CH4 m-2 day-1 median uncertainty level. Improving LEO CH4 measurement precision by 2 would only reduce the median CH4 flux uncertainty to 11.9 mg CH4 m-2 day-1. A GEO mission with targeted observing capability could resolve fluxes at a 2.0-2.4 mg CH4 m-2 day-1 median precision by increasing the observation density in high cloud-cover regions at the expense of other parts of the domain. We find that residual CH4 concentration biases can potentially reduce the ˜ 5-fold flux CH4 precision advantage of a GEO mission to a ˜ 2-fold advantage

  9. Atrazine reduces reproduction in fathead minnow (Pimephales promelas): raw data report

    Science.gov (United States)

    Tillitt, Donald E.; Papoulias, Diana M.; Whyte, Jeffrey J.; Richter, Catherine A.

    2014-01-01

    The herbicide, atrazine, routinely is observed in surface and groundwaters, particularly in the “corn belt” region, a high-use area of the United States. Atrazine has demonstrated effects on reproduction in mammals and amphibians, but the characterization of endocrine-related effects in fish has received only limited attention. Peak concentrations of atrazine in surface water of streams from these agricultural areas coincide with annual spawning events of native fishes. Consequently, there was an unacceptable level of uncertainty in our understanding of the risks associated with the periods of greatest atrazine exposure and greatest vulnerability of certain species of fishes. For this reason, a study of the effects of atrazine on fathead minnow reproduction was undertaken (Tillitt and others, 2010). This report provides the raw data from that study.

  10. NASA ExoPAG Study Analysis Group 5: Flagship Exoplanet Imaging Mission Science Goals and Requirements Report

    CERN Document Server

    Greene, Tom

    2013-01-01

    The NASA Exoplanet Program Analysis Group (ExoPAG) has undertaken an effort to define mission Level 1 requirements for exoplanet direct detection missions at a range of sizes. This report outlines the science goals and requirements for the next exoplanet flagship imaging and spectroscopy mission as determined by the flagship mission Study Analysis Group (SAG) of the NASA Exoplanet Program Analysis Group (ExoPAG). We expect that these goals and requirements will be used to evaluate specific architectures for a future flagship exoplanet imaging and spectroscopy mission, and we expect this effort to serve as a guide and template for similar goals and requirements for smaller missions, an effort that we expect will begin soon. These goals and requirements were discussed, determined, and documented over a 1 year period with contributions from approximately 60 volunteer exoplanet scientists, technologists, and engineers. Numerous teleconferences, emails, and several in-person meetings were conducted to progress on ...

  11. Evaluation of biotransformation products from 2,4-dinitrotoluene under nitrate-reducing conditions. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Freedman, D.L.; Noguera, D.R.

    1995-04-10

    Wastewater generated during the manufacture of munitions often contains significant levels of nitrates and 2,4-dinitrotoluene (DNT). The objective of this project was to characterize the major biotransformation products formed from DNT under denitrifying conditions, and to identify the organisms responsible. In a denitrifying enrichment culture that used ethanol as the primary substrate, DNT was transformed primarily to 2-amino-4-nitrotoluene, 4-arnino-2-nitrotoluene, and 2,4-diaminotoluene. With extended incubation (>% 80 days), all of the 2,4-diaminotoluene subsequently disappeared. In cultures that received 14Cdnt, nearly all of the labeled metabolites remained in the aqueous phase. Approximately 35% consisted of insoluble material, while 29% was soluble hydrophobic and 32% was soluble hydrophilic. Two organisms were isolated from the enrichment: Pseudomonas aeruginosa and a much slower-growing rod. Pure cultures of P. aeruginosa only partially reduced DNT to 2,4-diaminotoluene under both aerobic and denitrifying conditions. Accumulation of 2-amino-4-nitrotoluene accounted for 25-45% of the DNT consumed, while 4-acetylamino-2-nitrotoluene accounted for 32-35%. Reduction and acetylation therefore appear to be major biotransformation pathways for DNT under both aerobic and denitrifying conditions.

  12. Reducing Emissions of Volatile Organic Compounds - Final Report - 08/15/1997 - 02/14/2001

    Energy Technology Data Exchange (ETDEWEB)

    Stensel, H. David; Strand, Stuart E.

    2001-03-14

    The overall objective of this research was to determine if the shallow suspended growth reactor (SSGR) could provide sufficient treatment performance of organic and reduced sulfur (TRS) compounds, at 50 C to meet the EPA ''cluster rule'' regulatory limits. The biodegradation of a mixture of organic compounds that could be present in pulp and paper high volume low concentration gas streams was evaluated at 50 C in a bench-scale SSGR. The removal of methanol was followed in particular, and was mathematically modeled to evaluate the effect of process design and operating parameters on methanol removal. Additional tests were performed to obtain mass transfer and biodegradation kinetic parameters for the model. The acclimation of microbial populations capable of degrading TRS compounds from various seed sources was studied in batch reactors at 30 and 50 C. The degradation of TRS compounds in bench-scale SSGR was studied at 20-50 C. Also, the biodegradation kinetic and mass transfer coefficients for alpha-terpinene and gamma-terpinene were studied. Finally, a pilot plant was constructed and operated at Simpson pulp and paper mill in Tacoma, WA.

  13. Abstract of a report on reducing resistance in gas-fired preheaters

    Energy Technology Data Exchange (ETDEWEB)

    1939-04-27

    The demands of Hydro-works Scholven to increase the capacity of one of their preheaters, with consequently greater volume of circulating gases, inspired the idea to study the resistance to the flow of gases in the preheaters. The resistance varied with the square of the velocity, so that pressure differences beyond the capacity of the single-stage Schiele blowers could be easily developed. It was intended, therefore, to determine the exact course of the pressure loss in preheaters in operation at Scholven. Since this met with many practical difficulties, it was supplemented by measurements on sheet steel models built to one-tenth their actual size. The measurements on the preheaters already in service showed that the pressure loss in the heating chamber proper, that is the pressure losses applicable to heat transmission, were small compared to the total pressure loss. The greatest proportion of the heating loss occurred in the inlet and outlet ducts and passages. This indicated that particular attention must be paid to the resistance in the ducts and the distributing points. The gas distribution needed to be arranged such that energy-consuming dampers could be eliminated. Where bends could not be avoided, guide vanes could considerably reduce the pressure loss. It was suggested to use an Escher--Weiss axial blower system instead of the Schiele radial blower. Reduction of pressure losses would increase velocity of the gases in the heating flues and thus increase heat transmission in the hairpin coils.

  14. 26 CFR 5f.103-3 - Information reporting requirements for certain bonds.

    Science.gov (United States)

    2010-04-01

    ... issue, (4) The total purchase price of the issue, (5) The amount allocated to a reasonably required..., e.g., for a football stadium, that the property is described in section 103(b)(4)(B), (ii)...

  15. Engineering report. Part 1: NASA wheel air seal development for space shuttle type environmental requirements

    Science.gov (United States)

    1973-01-01

    The sealing techniques are studied for existing aircraft wheel-tire designs to meet the hard vacuum .00001 torr and cold temperature -65 F requirements of space travel. The investigation covers the use of existing wheel seal designs.

  16. 40 CFR 63.1211 - What are the recordkeeping and reporting requirements?

    Science.gov (United States)

    2010-07-01

    ... compression techniques, you must recommend: (i) A fluctuation limit that defines the maximum permissible deviation of a new data value from a previously generated value without requiring you to revert to...

  17. Memo Clarifying Requirements and State Reporting Guidance to Transition to the Revised Total Coliform Rule

    Science.gov (United States)

    This memorandum provides guidance to primacy agencies with enforcement responsibility under the Safe Drinking Water Act (SDWA) concerning the requirements to transition public water systems (PWSs) from the Total Coliform Rule (TCR) to the RTCR

  18. Early host cell reactivation of an oxidatively damaged adenovirus-encoded reporter gene requires the Cockayne syndrome proteins CSA and CSB.

    Science.gov (United States)

    Leach, Derrik M; Rainbow, Andrew J

    2011-03-01

    Reduced host cell reactivation (HCR) of a reporter gene containing 8-oxoguanine (8-oxoG) lesions in Cockayne syndrome (CS) fibroblasts has previously been attributed to increased 8-oxoG-mediated inhibition of transcription resulting from a deficiency in repair. This interpretation has been challenged by a report suggesting reduced expression from an 8-oxoG containing reporter gene occurs in all cells by a mechanism involving gene inactivation by 8-oxoG DNA glycosylase and this inactivation is strongly enhanced in the absence of the CS group B (CSB) protein. The observation of reduced gene expression in the absence of CSB protein led to speculation that decreased HCR in CS cells results from enhanced gene inactivation rather than reduced gene reactivation. Using an adenovirus-based β-galactosidase (β-gal) reporter gene assay, we have examined the effect of methylene blue plus visible light (MB + VL)-induced 8-oxoG lesions on the time course of gene expression in normal and CSA and CSB mutant human SV40-transformed fibroblasts, repair proficient and CSB mutant Chinese hamster ovary (CHO) cells and normal mouse embryo fibroblasts. We demonstrate that MB + VL treatment of the reporter leads to reduced expression of the damaged β-gal reporter relative to control at early time points following infection in all cells, consistent with in vivo inhibition of RNA polII-mediated transcription. In addition, we have demonstrated HCR of reporter gene expression occurs in all cell types examined. A significant reduction in the rate of gene reactivation in human SV40-transformed cells lacking functional CSA or CSB compared to normal cells was found. Similarly, a significant reduction in the rate of reactivation in CHO cells lacking functional CSB (CHO-UV61) was observed compared to the wild-type parental counterpart (CHO-AA8). The data presented demonstrate that expression of an oxidatively damaged reporter gene is reactivated over time and that CSA and CSB are required for

  19. 76 FR 7091 - Notice of Intent To Require Reporting Forms for Savings and Loan Holding Companies

    Science.gov (United States)

    2011-02-08

    ... reports would also collect organizational structure and ] activity information from SLHCs in order to... Changes in Organizational Structure. Agency form number: FR Y-10. Frequency: As needed, FR Y-10 is..._financial_and_structure_reports.pdf . A summary of these forms can be found below. The Board acknowledges...

  20. 42 CFR 422.516 - Validation of Part C reporting requirements.

    Science.gov (United States)

    2010-10-01

    ..., and report to CMS, to its enrollees, and to the general public, at the times and in the manner that.... (b) Significant business transactions. Each MA organization must report to CMS annually, within 120... must have been examined by an independent auditor in accordance with generally accepted accounting...

  1. 42 CFR 423.514 - Validation of Part D reporting requirements.

    Science.gov (United States)

    2010-10-01

    ..., evaluate, and report to CMS, to its enrollees, and to the general public, at the times and in the manner... report to CMS annually, within 120 days of the end of its fiscal year (unless, for good cause shown, CMS... statements must be examined by an independent auditor in accordance with generally accepted accounting...

  2. 40 CFR 80.370 - What are the sulfur reporting requirements?

    Science.gov (United States)

    2010-07-01

    ... importers exempted from corporate pool standards under § 80.216 or § 80.240 are exempt from reporting the... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What are the sulfur reporting... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur Recordkeeping and...

  3. Reduced dust emission industrial vacuum system. Final report/project accomplishments summary, CRADA Number KCP941001

    Energy Technology Data Exchange (ETDEWEB)

    Yerganian, S. [Allied-Signal Aerospace Co., Kansas City, MO (United States). Kansas City Div.; Wilson, S. [Billy Goat Industries, Lee`s Summit, MO (United States)

    1997-02-01

    The purpose of this project was to modify the design of a Billy Goat Industries VQ series industrial litter vacuum cleaner currently in production to allow it to be effective in a dusty environment. Other desired results were that the new design be easily and economically manufacturable, safe and easy for the operator to use and maintain, and easily adaptable to the rest of the Billy Goat Industries product line. To meet these objectives, the project plan was divided into four main phases. The first phase consisted of design overview and concept development. The second phase consisted of developing a detailed design based on the lessons learned from the prototype built in the first phase. The third phase consisted of refinement of the detailed design based on testing and marketing review. The fourth phase consisted of final reporting on the activities of the CRADA. The project has been terminated due to technical difficulties and a lack of confidence that practical, marketable solutions to these problems could be found.

  4. An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations.

    Science.gov (United States)

    Platt, Emily J; Durnin, James P; Shinde, Ujwal; Kabat, David

    2007-11-16

    Binding of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp120 to the CCR5 co-receptor reduces constraints on the metastable transmembrane subunit gp41, thereby enabling gp41 refolding, fusion of viral and cellular membranes, and infection. We previously isolated adapted HIV-1(JRCSF) variants that more efficiently use mutant CCR5s, including CCR5(Delta18) lacking the important tyrosine sulfate-containing amino terminus. Effects of mutant CCR5 concentrations on HIV-1 infectivities were highly cooperative, implying that several may be required. However, because wild-type CCR5 efficiently mediates infections at trace concentrations that were difficult to measure accurately, analyses of its cooperativity were not feasible. New HIV-1(JRCSF) variants efficiently use CCR5(HHMH), a chimera containing murine extracellular loop 2. The adapted virus induces large syncytia in cells containing either wild-type or mutant CCR5s and has multiple gp120 mutations that occurred independently in CCR5(Delta18)-adapted virus. Accordingly, these variants interchangeably use CCR5(HHMH) or CCR5(Delta18). Additional analyses strongly support a novel energetic model for allosteric proteins, implying that the adaptive mutations reduce quaternary constraints holding gp41, thus lowering the activation energy barrier for membrane fusion without affecting bonds to specific CCR5 sites. In accordance with this mechanism, highly adapted HIV-1s require only one associated CCR5(HHMH), whereas poorly adapted viruses require several. However, because they are allosteric ensembles, complexes with additional co-receptors fuse more rapidly and efficiently than minimal ones. Similarly, wild-type HIV-1(JRCSF) is highly adapted to wild-type CCR5 and minimally requires one. The adaptive mutations cause resistances to diverse entry inhibitors and cluster appropriately in the gp120 trimer interface overlying gp41. We conclude that membrane fusion complexes are allosteric machines with an

  5. 30 CFR 250.210 - If I conduct ancillary activities, what reporting and data/information retention requirements...

    Science.gov (United States)

    2010-07-01

    ... OPERATIONS IN THE OUTER CONTINENTAL SHELF Plans and Information Ancillary Activities § 250.210 If I conduct ancillary activities, what reporting and data/information retention requirements must I satisfy? (a... data or information obtained or derived from your ancillary activities. When applicable, MMS...

  6. 49 CFR 579.22 - Reporting requirements for manufacturers of 100 or more buses, manufacturers of 500 or more...

    Science.gov (United States)

    2010-10-01

    ... system, air, 05 parking brake, 06 engine and engine cooling system, 07 fuel system, gasoline, 08 fuel... model that is manufactured and available with more than one type of service brake system (i.e., hydraulic or air), the information required by this subsection shall be reported by each of the two...

  7. 49 CFR 579.24 - Reporting requirements for manufacturers of 5,000 or more trailers annually.

    Science.gov (United States)

    2010-10-01

    ... system, hydraulic, 04 service brake system, air, 05 parking brake, 11 electrical, 12 exterior lighting... with more than one type of service brake system (i.e., hydraulic and air), the information required by this subsection shall be reported by each of the two brake types (i.e., “H” for hydraulic, “A” for...

  8. 40 CFR 80.593 - What are the reporting requirements for refiners and importers of motor vehicle diesel fuel...

    Science.gov (United States)

    2010-07-01

    ... for refiners and importers of motor vehicle diesel fuel subject to temporary refiner relief standards... PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive... the reporting requirements for refiners and importers of motor vehicle diesel fuel subject...

  9. AN INVESTIGATION OF THE TRAINING AND SKILL REQUIREMENTS OF INDUSTRIAL MACHINERY MAINTENANCE WORKERS. VOLUME II. FINAL REPORT.

    Science.gov (United States)

    LYNN, FRANK

    THE APPENDIXES FOR "AN INVESTIGATION OF THE TRAINING AND SKILL REQUIREMENTS OF INDUSTRIAL MACHINERY MAINTENANCE WORKERS, FINAL REPORT, VOLUME I" (VT 004 006) INCLUDE (1) TWO LETTERS FROM PLANT ENGINEERS STRESSING THE IMPORTANCE OF TRAINING MACHINERY MAINTENANCE WORKERS, (2) A DESCRIPTION OF THE MAINTENANCE TRAINING SURVEY, A SAMPLE QUESTIONNAIRE,…

  10. 20 CFR 416.919n - Informing the medical source of examination scheduling, report content, and signature requirements.

    Science.gov (United States)

    2010-04-01

    ... examination—at least 60 minutes (Additional time may be required depending on types of psychological tests... Disability and Blindness Standards for the Type of Referral and for Report Content § 416.919n Informing the... any needed tests. The following minimum scheduling intervals (i.e., time set aside for the individual...

  11. 12 CFR 225.175 - What risk management, record keeping and reporting policies are required to make merchant banking...

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false What risk management, record keeping and reporting policies are required to make merchant banking investments? 225.175 Section 225.175 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM BANK HOLDING...

  12. 33 CFR 169.205 - What types of ships are required to transmit LRIT information (position reports)?

    Science.gov (United States)

    2010-07-01

    ... SYSTEMS Transmission of Long Range Identification and Tracking Information § 169.205 What types of ships... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false What types of ships are required to transmit LRIT information (position reports)? 169.205 Section 169.205 Navigation and...

  13. 40 CFR 80.594 - What are the pre-compliance reporting requirements for motor vehicle diesel fuel?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false What are the pre-compliance reporting requirements for motor vehicle diesel fuel? 80.594 Section 80.594 Protection of Environment ENVIRONMENTAL... likely be available in its marketing area after June 1, 2006 and through 2010; (ii) If after 2003...

  14. 26 CFR 1.402A-2 - Reporting and recordkeeping requirements with respect to designated Roth accounts.

    Science.gov (United States)

    2010-04-01

    ... respect to designated Roth accounts. 1.402A-2 Section 1.402A-2 Internal Revenue INTERNAL REVENUE SERVICE... Bonus Plans, Etc. § 1.402A-2 Reporting and recordkeeping requirements with respect to designated Roth... investment in the contract, i.e., the amount of unrecovered designated Roth contributions for the employee?...

  15. Norms for Required and Elective Courses by Course Level for the IIQ Subscales. Technical Report No. 11.1-72.

    Science.gov (United States)

    Pohlmann, John T.; And Others

    The development of norms for five subscales from the Instructional Improvement Questionnaire (IIQ) are reported for required and elective courses at each course level. The IIQ is a student rating form designed to provide evaluative feedback to instructors about their teaching. The subscales of the IIQ were derived from the results of an earlier…

  16. 40 CFR Table 6 to Subpart Ppp of... - Process Vents From Continuous Unit Operations-Monitoring, Recordkeeping, and Reporting Requirements

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 11 2010-07-01 2010-07-01 true Process Vents From Continuous Unit Operations-Monitoring, Recordkeeping, and Reporting Requirements 6 Table 6 to Subpart PPP of Part 63... Subpart PPP of Part 63—Process Vents From Continuous Unit Operations—Monitoring, Recordkeeping, and...

  17. 76 FR 14812 - Final Regulation Extending the Reporting Deadline for Year 2010 Data Elements Required Under the...

    Science.gov (United States)

    2011-03-18

    ... Review B. Paperwork Reduction Act C. Regulatory Flexibility Act (RFA) D. Unfunded Mandates Reform Act... facilities. 331492 Zinc dust reclaiming facilities, recovering from scrap and/or alloying purchased metals... addition of facility- and parent-level reporting requirements (75 FR 57669, September 22, 2010); technical...

  18. MORE: Management of requirements in NPP modernisation projects. Project report 2007

    Energy Technology Data Exchange (ETDEWEB)

    Fredriksen, R.; Katta, V.; Raspotnig, C. [Institutt for energiteknikk (IFE) (Norway); Valkonen, J. [Technical Research Centre of Finland (VTT) (Finland)

    2008-03-15

    This report documents the work and related activities of the MORE project in the period January 1 - December 31 in 2007. The focus of this report is on improvements of the former project results, to identify and apply a couple of case studies from NPP projects, and activities in order to initiate and implement the industrial take-up and utilisation of the research results in real modernisation projects. The report also provides a brief description of the extended industrial network and disseminations of the results in Nordic and NKS related events such as seminars and workshops. (au)

  19. Stereotactic Radiosurgery for Trigeminal Neuralgia Improves Patient-Reported Quality of Life and Reduces Depression.

    Science.gov (United States)

    Kotecha, Rupesh; Miller, Jacob A; Modugula, Sujith; Barnett, Gene H; Murphy, Erin S; Reddy, Chandana A; Suh, John H; Neyman, Gennady; Machado, Andre; Nagel, Sean; Chao, Samuel T

    2017-08-01

    To characterize quality-of-life (QOL) outcomes after stereotactic radiosurgery (SRS) for trigeminal neuralgia (TN). The EuroQOL 5 Dimensions (EQ-5D) and Patient Health Questionnaire 9 (PHQ-9) were prospectively collected before and after SRS for 50 patients with TN. Pain response and treatment-related facial numbness were classified by Barrow Neurological Institute (BNI) scales. Differences in pooled QOL outcomes were tested with paired t tests and sign tests. The Kaplan-Meier method was used to estimate time-dependent improvements in the EQ-5D index, EQ-5D perceived health status (PHS), PHQ-9 score, and freedom from pain failure (BNI class IV-V) or facial numbness (BNI class III-IV). Following SRS, the 12-month rate of freedom from pain failure was 92% (95% confidence interval [CI], 77%-97%) while the 12-month rate of freedom from facial numbness was 89% (95% CI, 66%-97%). Significant improvements in the EQ-5D index (P<.01), PHS (P=.01), and PHQ-9 (P=.03) were observed, driven by the EQ-5D subscores for self-care and for pain and/or discomfort (P=.02 and P<.01, respectively). At 12 months after SRS, the actuarial rates of improvement in the EQ-5D, PHS, and PHQ-9 were 55% (95% CI, 40%-70%), 59% (95% CI, 40%-76%), and 59% (95% CI, 39%-76%), respectively. The median time to improvement in each of the QOL measures was 9 months (95% CI, 3-36 months) for the EQ-5D index, 5 months (95% CI, 3-36 months) for PHS, and 9 months (95% CI, 3-18 months) for the PHQ-9. On multivariate analysis, only higher prescription dose (86 Gy vs ≤82 Gy) was associated with improvement in the EQ-5D index (hazard ratio, 5.73; 95% CI, 1.85-22.33; P<.01). Patients with TN treated with SRS reported significant improvements in multiple QOL measures, with the therapeutic benefit strongly driven by improvements in pain and/or discomfort and in self-care, along with lower rates of depression. In this analysis, there appears to be a correlation between prescription dose and treatment

  20. Aspirated safety pin requiring thoracotomy: report of a case and review.

    Science.gov (United States)

    Causey, A L; Talton, D S; Miller, R C; Warren, E T

    1997-12-01

    Foreign body aspirations in children are relatively uncommon occurrences, but they can be a serious events, causing respiratory distress, atelectasis, chronic pulmonary infections, or death. Safety pins are not commonly aspirated objects and account for less than 3% of all foreign bodies found in the tracheobronchial tree. Fewer than 2% of patients require thoracotomy, and most aspirated materials can be removed by bronchoscopy, with low morbidity and mortality. A discussion of airway foreign bodies follows the presentation of a case of an older child who aspirated a safety pin, which required open thoracostomy for removal.

  1. Report: Management Alert - EPA Has Not Initiated Required Background Investigations for Information Systems Contractor Personnel

    Science.gov (United States)

    Report #17-P-0409, September 27, 2017. Not vetting contractor personnel before granting them network access exposes the EPA to risks. Contractor personnel with potentially questionable backgrounds who access sensitive agency data could cause harm.

  2. Greenhouse Gas Reporting Requirements Related to Stationary Refrigeration and Air Conditioning

    Science.gov (United States)

    Provides links to information about parts of the 2009 Mandatory Reporting of Greenhouse Gases Rule that are relevant to owners and importers of stationary refrigeration and air-conditioning equipment.

  3. 40 CFR 82.24 - Recordkeeping and reporting requirements for class II controlled substances.

    Science.gov (United States)

    2010-07-01

    ... facility; (vii) Dated records of the quantity (in kilograms) of raw materials and feedstock chemicals used...) Recordkeeping and reporting. Any person who produces, imports, exports, transforms, or destroys class II... total of expended and unexpended production allowances, consumption allowances, export...

  4. 75 FR 75936 - Required Warnings for Cigarette Packages and Advertisements; Research Report

    Science.gov (United States)

    2010-12-07

    ... Cigarette Packages and Advertisements; Research Report AGENCY: Food and Drug Administration, HHS. ACTION... warnings and accompanying graphics to be displayed on cigarette packages and in cigarette advertisements... health warning statements appear on cigarette packages and in cigarette advertisements. Section 201...

  5. 42 CFR 457.720 - State plan requirement: State assurance regarding data collection, records, and reports.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS (SCHIPs) ALLOTMENTS AND GRANTS TO STATES Strategic Planning, Reporting, and Evaluation § 457.720... monitor State program administration and compliance and to evaluate and compare the effectiveness of State...

  6. 78 FR 15615 - Reporting Requirements for U.S. Providers of International Telecommunications Services

    Science.gov (United States)

    2013-03-12

    ... Telecommunications Services AGENCY: Federal Communications Commission. ACTION: Final rule. SUMMARY: In this document... telecommunications services, the Commission consolidated the traffic and revenue and circuit status reports into one... the current state of the international telecommunications market. DATES: Effective April 11,...

  7. The No Shelf Required Guide to E-book Purchasing A Library Technology Report

    CERN Document Server

    Polanka, Sue

    2011-01-01

    This issue of "Library Technology Reports" provides strategies, best practices, and case studies for meeting the unprecedented legal, technological, and vendor challenges that come with e-book purchasing.

  8. 78 FR 36632 - Reports, Forms, and Recordkeeping Requirements; Agency Information Collection Activity Under OMB...

    Science.gov (United States)

    2013-06-18

    ... reduce texting and driving. The program will be conducted at the community level in two States.... The current project would expand the distracted driving program to focus on texting behavior. This.... Title: NHTSA Distracted Driving Survey Project. Form No.: NHTSA Form 1084. Type of Review: Revision...

  9. Reporting systems in gastrointestinal endoscopy: Requirements and standards facilitating quality improvement: European Society of Gastrointestinal Endoscopy position statement

    Science.gov (United States)

    Aabakken, Lars; Dekker, Evelien; Kaminski, Michal F; Rösch, Thomas; Hultcrantz, Rolf; Suchanek, Stepan; Jover, Rodrigo; Kuipers, Ernst J; Bisschops, Raf; Spada, Cristiano; Valori, Roland; Domagk, Dirk; Rees, Colin; Rutter, Matthew D

    2016-01-01

    To develop standards for high quality of gastrointestinal endoscopy, the European Society of Gastrointestinal Endoscopy (ESGE) has established the ESGE Quality Improvement Committee. A prerequisite for quality assurance and improvement for all gastrointestinal endoscopy procedures is state-of-the-art integrated digital reporting systems for standardized documentation of the procedures. The current paper describes the ESGE’s viewpoints on requirements for high-quality endoscopy reporting systems. The following recommendations are issued: Endoscopy reporting systems must be electronic.Endoscopy reporting systems should be integrated into hospital patient record systems.Endoscopy reporting systems should include patient identifiers to facilitate data linkage to other data sources.Endoscopy reporting systems shall restrict the use of free text entry to a minimum, and be based mainly on structured data entry.Separate entry of data for quality or research purposes is discouraged. Automatic data transfer for quality and research purposes must be facilitated.Double entry of data by the endoscopist or associate personnel is discouraged. Available data from outside sources (administrative or medical) must be made available automatically.Endoscopy reporting systems shall enable the inclusion of information on histopathology of detected lesions; patient’s satisfaction; adverse events; surveillance recommendations.Endoscopy reporting systems must facilitate easy data retrieval at any time in a universally compatible format.Endoscopy reporting systems must include data fields for key performance indicators as defined by quality improvement committees.Endoscopy reporting systems must facilitate changes in indicators and data entry fields as required by professional organizations. PMID:27087943

  10. NCI Workshop Report: Clinical and Computational Requirements for Correlating Imaging Phenotypes with Genomics Signatures

    Directory of Open Access Journals (Sweden)

    Rivka Colen

    2014-10-01

    Full Text Available The National Cancer Institute (NCI Cancer Imaging Program organized two related workshops on June 26–27, 2013, entitled “Correlating Imaging Phenotypes with Genomics Signatures Research” and “Scalable Computational Resources as Required for Imaging-Genomics Decision Support Systems.” The first workshop focused on clinical and scientific requirements, exploring our knowledge of phenotypic characteristics of cancer biological properties to determine whether the field is sufficiently advanced to correlate with imaging phenotypes that underpin genomics and clinical outcomes, and exploring new scientific methods to extract phenotypic features from medical images and relate them to genomics analyses. The second workshop focused on computational methods that explore informatics and computational requirements to extract phenotypic features from medical images and relate them to genomics analyses and improve the accessibility and speed of dissemination of existing NIH resources. These workshops linked clinical and scientific requirements of currently known phenotypic and genotypic cancer biology characteristics with imaging phenotypes that underpin genomics and clinical outcomes. The group generated a set of recommendations to NCI leadership and the research community that encourage and support development of the emerging radiogenomics research field to address short-and longer-term goals in cancer research.

  11. 75 FR 4728 - Occupational Injury and Illness Recording and Reporting Requirements

    Science.gov (United States)

    2010-01-29

    ... United States'' (66 FR 6030). OSHA also noted that, in the past, determining the ] number of MSD cases.... OSHA has modified the proposed regulatory text to highlight the ``DO NOT include'' language by using... requiring only first aid treatment and which do not involve medical treatment, loss of consciousness...

  12. 75 FR 3193 - Application Package and Reporting Requirements for the Veterinary Medicine Loan Repayment Program...

    Science.gov (United States)

    2010-01-20

    ... Veterinary Medicine Loan Repayment Program (VMLRP) AGENCY: National Institute of Food and Agriculture, USDA... Veterinary Medicine Loan Repayment Program (VMLRP). This Notice initiates a 60-day comment period and... requirements for the Veterinary Medicine Loan Repayment Program (VMLRP) as authorized under section 1415A...

  13. 46 CFR 67.113 - Managing owner designation; address; requirement to report change of address.

    Science.gov (United States)

    2010-10-01

    ... change of address. The owner of each vessel must designate a managing owner on the Application for...) Whenever the address of the managing owner changes, the managing owner shall notify the Director, National... 46 Shipping 2 2010-10-01 2010-10-01 false Managing owner designation; address; requirement to...

  14. 75 FR 80685 - Contract Reporting Requirements of Intrastate Natural Gas Companies

    Science.gov (United States)

    2010-12-23

    ... monitor actual transactions for evidence of possible abuse of market power or undue discrimination. The... to permit more effective monitoring for the exercise of market power and undue discrimination. As...' contracts with their shippers.\\30\\ In the NGA and the Federal Power Act (FPA), Congress required...

  15. 45 CFR 73.735-901 - Reporting requirement of the Ethics in Government Act of 1978.

    Science.gov (United States)

    2010-10-01

    ... Act of 1978. 73.735-901 Section 73.735-901 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES... requirement of the Ethics in Government Act of 1978. (a) Applicability. The following employees and special... Title II of the Ethics in Government Act of 1978, Pub. L. 95-521, as amended: (1) Officers and...

  16. 10 CFR 905.16 - What are the requirements for the minimum investment report alternative?

    Science.gov (United States)

    2010-01-01

    ...; and (iv) A description of the DSM and/or renewable energy activities to be undertaken over the next 2... for DSM and/or renewable energy. (b) Minimum investment requirement. The minimum investment must be... DSM and/or renewable energy mandated by a State, Tribal, or Federal Government with...

  17. 13 CFR 120.1511 - Certification and other reporting and notification requirements for Other Regulated SBLCs.

    Science.gov (United States)

    2010-01-01

    ...) Certification. An SBLC seeking Other Regulated SBLC status must certify to SBA in writing that its lending... or state banking regulator that regulates the lending activities of the SBLC; (2) A statement that... may appeal this decision to the AA/CA. (g) Failure to satisfy requirements. In the event that an...

  18. 76 FR 63582 - Reporting Requirements for Positive Train Control Expenses and Investments

    Science.gov (United States)

    2011-10-13

    ... of UP's petition and The Fertilizer Institute (TFI) replied in opposition. On November 24, 2010, the Norfolk Southern Railway Company (NSR) late-filed comments in support of UP's petition, and on January 18... schedule separate from the R-1 filings currently required--should provide us with important...

  19. 77 FR 70150 - Fisheries of the Exclusive Economic Zone Off Alaska; Recordkeeping and Reporting Requirements...

    Science.gov (United States)

    2012-11-23

    ... Swedish Cultural Center located at 1920 Dexter Ave N., Seattle, WA. Directions to the center can be found...: Susan Hall, 907-586-7462. SUPPLEMENTARY INFORMATION: The workshop will include a discussion of ] 2013... longline fleet (77 FR 59053) mandates that vessel operators who opt into the program will be required...

  20. 75 FR 41087 - Conforming Changes to Applicant Submission Requirements; Implementing Federal Financial Report...

    Science.gov (United States)

    2010-07-15

    ... direct compliance costs on state and local governments and is not required by statute, or the rule... compliance costs on state and local governments or preempt state law within the meaning of the Executive..., Aged, Claims, Crime, Government contracts, Grants programs-housing and community...