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Sample records for recommended half-life values

  1. Average and recommended half-life values for two neutrino double beta decay

    CERN Document Server

    Barabash, A S

    2015-01-01

    All existing positive results on two neutrino double beta decay in different nuclei were analyzed. Using the procedure recommended by the Particle Data Group, weighted average values for half-lives of $^{48}$Ca, $^{76}$Ge, $^{82}$Se, $^{96}$Zr, $^{100}$Mo, $^{100}$Mo - $^{100}$Ru ($0^+_1$), $^{116}$Cd, $^{130}$Te, $^{136}$Xe, $^{150}$Nd, $^{150}$Nd - $^{150}$Sm ($0^+_1$) and $^{238}$U were obtained. Existing geochemical data were analyzed and recommended values for half-lives of $^{128}$Te, and $^{130}$Ba are proposed. Given the measured half-life values, nuclear matrix elements were calculated using latest (more reliable and precise) values for phase space factor. Finally, previous results (PRC 81 (2010) 035501) were up-dated and results for $^{136}$Xe were added.

  2. Average and recommended half-life values for two neutrino double beta decay: upgrade'05

    CERN Document Server

    Barabash, A S

    2006-01-01

    All existing ``positive'' results on two neutrino double beta decay in different nuclei were analyzed. Using the procedure recommended by the Particle Data Group, weighted average values for half-lives of $^{48}$Ca, $^{76}$Ge, $^{82}$Se, $^{96}$Zr, $^{100}$Mo, $^{100}$Mo - $^{100}$Ru ($0^+_1$), $^{116}$Cd, $^{150}$Nd, $^{150}$Nd - $^{150}$Sm ($0^+_1$) and $^{238}$U were obtained. Existing geochemical data were analyzed and recommended values for half-lives of $^{128}$Te, $^{130}$Te and $^{130}$Ba are proposed. We recommend the use of these results as presently the most precise and reliable values for half-lives.

  3. Average and recommended half-life values for two neutrino double beta decay: upgrade-09

    CERN Document Server

    Barabash, A S

    2009-01-01

    All existing ``positive'' results on two neutrino double beta decay in different nuclei were analyzed. Using the procedure recommended by the Particle Data Group, weighted average values for half-lives of $^{48}$Ca, $^{76}$Ge, $^{82}$Se, $^{96}$Zr, $^{100}$Mo, $^{100}$Mo - $^{100}$Ru ($0^+_1$), $^{116}$Cd, $^{130}$Te, $^{150}$Nd, $^{150}$Nd - $^{150}$Sm ($0^+_1$) and $^{238}$U were obtained. Existing geochemical data were analyzed and recommended values for half-lives of $^{128}$Te, $^{130}$Te and $^{130}$Ba are proposed. We recommend the use of these results as presently the most precise and reliable values for half-lives.

  4. Average and recommended half-life values for two neutrino double beta decay: upgrade-2013

    CERN Document Server

    Barabash, A S

    2013-01-01

    All existing positive results on two neutrino double beta decay in different nuclei were analyzed. Using the procedure recommended by the Particle Data Group, weighted average values for half-lives of $^{48}$Ca, $^{76}$Ge, $^{82}$Se, $^{96}$Zr, $^{100}$Mo, $^{100}$Mo - $^{100}$Ru ($0^+_1$), $^{116}$Cd, $^{130}$Te, $^{136}$Xe, $^{150}$Nd, $^{150}$Nd - $^{150}$Sm ($0^+_1$) and $^{238}$U were obtained. Existing geochemical data were analyzed and recommended values for half-lives of $^{128}$Te and $^{130}$Ba are proposed. I recommend the use of these results as the most currently reliable values for half-lives.

  5. Precise half-life values for two neutrino double beta decay

    CERN Document Server

    Barabash, A S

    2010-01-01

    All existing "positive" results on two neutrino double beta decay in different nuclei were analyzed. Using the procedure recommended by the Particle Data Group, weighted average values for half-lives of $^{48}$Ca, $^{76}$Ge, $^{82}$Se, $^{96}$Zr, $^{100}$Mo, $^{100}$Mo - $^{100}$Ru ($0^+_1$), $^{116}$Cd, $^{130}$Te, $^{150}$Nd, $^{150}$Nd - $^{150}$Sm($0^+_1$) and $^{238}$U were obtained. Existing geochemical data were analyzed and recommended values for half-lives of $^{128}$Te, $^{130}$Te and $^{130}$Ba are proposed. Given the measured half-life values, nuclear matrix elements were calculated. I recommend the use of these results as the most currently reliable values for the half-lives and nuclear matrix elements.

  6. Standard Operating Procedure for Using the NAFTA Guidance to Calculate Representative Half-life Values and Characterizing Pesticide Degradation

    Science.gov (United States)

    Results of the degradation kinetics project and describes a general approach for calculating and selecting representative half-life values from soil and aquatic transformation studies for risk assessment and exposure modeling purposes.

  7. A new value for the half-life of {sup 10}Be by Heavy-Ion Elastic Recoil Detection and liquid scintillation counting

    Energy Technology Data Exchange (ETDEWEB)

    Korschinek, G., E-mail: Gunther.Korschinek@ph.tum.d [Physik Department, Technische Universitaet Muenchen, D-85748 Garching (Germany); Bergmaier, A. [Universitaet der Bundeswehr Muenchen, Fakultaet fuer Luft- und Raumfahrttechnik, Institut fuer Angewandte Physik und Messtechnik LRT2, Werner-Heisenberg-Weg 39, D-85577 Neubiberg (Germany); Faestermann, T. [Physik Department, Technische Universitaet Muenchen, D-85748 Garching (Germany); Gerstmann, U.C. [Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Radiation Protection, Ingolstaedter Landstr. 1, D-85764 Neuherberg (Germany); Knie, K.; Rugel, G. [Physik Department, Technische Universitaet Muenchen, D-85748 Garching (Germany); Wallner, A. [VERA Laboratory, Faculty of Physics, University of Vienna, Waehringer Strasse 17, A-1090 Wien (Austria); Dillmann, I. [Physik Department, Technische Universitaet Muenchen, D-85748 Garching (Germany); Dollinger, G. [Universitaet der Bundeswehr Muenchen, Fakultaet fuer Luft- und Raumfahrttechnik, Institut fuer Angewandte Physik und Messtechnik LRT2, Werner-Heisenberg-Weg 39, D-85577 Neubiberg (Germany); Lierse von Gostomski, Ch. [Lehrstuhl fuer Radiochemie, Technische Universitaet Muenchen, D-85748 Garching (Germany); Kossert, K. [Physikalisch-Technische Bundesanstalt, Braunschweig (Germany); Maiti, M.; Poutivtsev, M. [Physik Department, Technische Universitaet Muenchen, D-85748 Garching (Germany); Remmert, A. [Lehrstuhl fuer Radiochemie, Technische Universitaet Muenchen, D-85748 Garching (Germany)

    2010-01-15

    The importance of {sup 10}Be in different applications of accelerator mass spectrometry (AMS) is well-known. In this context the half-life of {sup 10}Be has a crucial impact, and an accurate and precise determination of the half-life is a prerequisite for many of the applications of {sup 10}Be in cosmic-ray and earth science research. Recently, the value of the {sup 10}Be half-life has been the centre of much debate. In order to overcome uncertainties inherent in previous determinations, we introduced a new method of high accuracy and precision. An aliquot of our highly enriched {sup 10}Be master solution was serially diluted with increasing well-known masses of {sup 9}Be. We then determined the initial {sup 10}Be concentration by least square fit to the series of measurements of the resultant {sup 10}Be/{sup 9}Be ratio. In order to minimize uncertainties because of mass bias which plague other low-energy mass spectrometric methods, we used for the first time Heavy-Ion Elastic Recoil Detection (HI-ERD) for the determination of the {sup 10}Be/{sup 9}Be isotopic ratios, a technique which does not suffer from difficult to control mass fractionation. The specific activity of the master solution was measured by means of accurate liquid scintillation counting (LSC). The resultant combination of the {sup 10}Be concentration and activity yields a {sup 10}Be half-life of T{sub 1/2} = 1.388 +- 0.018 (1 s, 1.30%) Ma. In a parallel but independent study (Chmeleff et al. ), found a value of 1.386 +- 0.016 (1.15%) Ma. Our recommended weighted mean and mean standard error for the new value for {sup 10}Be half-life based on these two independent measurements is 1.387 +- 0.012 (0.87%) Ma.

  8. Q value and half-life of double-electron capture in Os-184

    CERN Document Server

    Smorra, C; Beyer, T; Blaum, K; Block, M; Düllmann, Ch E; Eberhardt, K; Eibach, M; Eliseev, S; Langanke, K; Martinez-Pinedo, G; Nagy, Sz; Nörtershäuser, W; Renisch, D; Shabaev, V M; Tupitsyn, I I; Zubova, N A

    2012-01-01

    Os-184 has been excluded as a promising candidate for the search of neutrinoless double-electron capture. High-precision mass measurements with the Penning-trap mass spectrometer TRIGA-TRAP resulted in a marginal resonant enhancement with = -8.89(58) keV excess energy to the 1322.152(22) keV 0+ excited state in W-184. State-of-the-art energy density functional calculations are applied for the evaluation of the nuclear matrix elements to the excited states predicting a strong suppression due to the large deformation of mother and daughter states. The half-life of the transition in Os-184 exceeds T_{1/2} > 1.3 10^{29} years for an effective neutrino mass of 1 eV.

  9. The half-life of 18F.

    Science.gov (United States)

    García-Toraño, Eduardo; Medina, Virginia Peyrés; Ibarra, Miguel Roteta

    2010-01-01

    The half-life of the positron-emitter (18)F has been measured by following the decay rate with three systems: ionization chambers, Ge detectors and coincidence with fast scintillators. The decay rate was measured for periods of time up to 9 half-lives. The combination of the results obtained with the three measuring systems gives a value of T(1/2)=1.82871 (18)h, in good agreement with recommended data and with an estimated uncertainty lower than any other previously reported value. Copyright 2009 Elsevier Ltd. All rights reserved.

  10. Half Life Measurements in {sup 155}Gd

    Energy Technology Data Exchange (ETDEWEB)

    Malmskog, S.G.

    1966-08-15

    In the literature there exists a definite difference for the half life of the 86.5 keV level in Gd depending on whether {sup 155}Eu or {sup 155}Tb sources have been used. Using a good energy resolution electron-electron coincidence spectrometer and a {sup 155}Eu source, a half life of 6.48 {+-} 0.26 nsec was obtained for the 86.5 keV level. This is in agreement with the values previously measured with {sup 155}Tb sources. The half life of the 105.4 keV level was measured to be 1.12 {+-} 0.05 nsec.

  11. Half-life of 31Si

    CERN Document Server

    D'Agostino, Giancarlo; Mana, Giovanni; Oddone, Massimo

    2016-01-01

    Half-life values are widely used in nuclear chemistry to model the exponential decay of the quantified radionuclides. The analysis of existing data reveals a general lack of information on the performed experiments and an almost complete absence of uncertainty budgets. This is the situation for 31Si, the radionuclide produced via neutron capture reaction recently used to quantify trace amounts of 30Si in a sample of the silicon material highly enriched in 28Si and used for the determination of the Avogadro constant. In order to improve the quality of the now recommended 157.36(26) min value, we carried out repeated observations of the 31Si decay rate via gamma-ray spectrometry measurements. This paper reports the result we obtained, including details of the experiment and the evaluation of the uncertainty.

  12. Precision measurement of the half-life and the $\\beta$-decay Q value of the superallowed 0$^{+}\\rightarrow$ 0$^{+}\\beta$-decay of $^{38}$Ca

    CERN Multimedia

    2002-01-01

    We propose to study the $\\beta$-decay of $^{38}$Ca. In a first instance, we intend to perform a high-precision study of the half-life of this nucleus as well as a measurement of its $\\beta$-decay Q-value with ISOLTRAP. At a later stage, we propose to study its decay branches to determine the super-allowed branching ratio with high precision. These measurements are essential to improve our understanding of the theoretical corrections (in particular the $\\delta$c correction factor) needed to calculate the universal Ft value from the ft value determined for individual nuclei. For this nucleus, the correction factor is predicted to increase significantly as compared to the nine well-studied nuclei between $^{10}$C and $^{54}$Co and the model calculations used to determine the corrections, in particular the shell-model calculations, are well under control in this mass region. Therefore, the T$_{Z}$= -1 nuclei between A=18 and A=38 are ideal test cases for the correction factors which limit today the precision on t...

  13. Update of NIST half-life results corrected for ionization chamber source-holder instability.

    Science.gov (United States)

    Unterweger, M P; Fitzgerald, R

    2014-05-01

    As reported at the ICRM 2011, it was discovered that the source holder used for calibrations in the NIST 4πγ ionization chamber (IC) was not stable. This has affected a large number of half-life measurement results previously reported and used in compilations of nuclear data. Corrections have been made on all of the half-life data based on the assumption that the changes to the ionization chamber response were gradual. The corrections are energy dependent and therefore radionuclide specific. This presentation will review our results and present the recommended changes in half-life values and/or uncertainties.

  14. Half-life of {sup 44}Ti

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, I.; Kutschera, W.; Castagnoli, G. [Instituto di Cosmogeofisica, Torino (Italy); Paul, M. [Hebrew Univ., Jerusalem (Israel)

    1995-08-01

    The measurement of the {sup 44}Ti half-life, started 3 years ago, is still continuing. The goal of this measurement is to determine the half-life of {sup 44}Ti, which is {approximately}52 y, to a precision of {approximately}5%. An accurate value of this half-life is of interest to cosmologists who need it to determine the production of heavy elements in supernova. Three sets of samples - a pure 200-nCi {sup 44}Ti sample, a pure 300-nCi {sup 60}Co source, and a mixed {sup 44}Ti-{sup 60}Co source of similar strength - were prepared and their spectra are being measured with Ge spectrometers at Argonne, Torino and Jerusalem. Each sample is counted for a period of 2 days, at approximate intervals of 4 months. The room background is also measured for the same length of time. We hope to start data analysis at the end of summer and obtain a value for the {sup 44}Ti half-life.

  15. Calculation of half-life for 79Se decay

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The half-life for 79Se decay is calculated by using the Logf1ut systematics method. Based on the data analysis and comparison with experimental data the 79Se half-life is recommended. The scheme for 79Se decay is also shown and the radiation data are calculated in the text.

  16. The half-life of {sup 18}F

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Torano, Eduardo, E-mail: e.garciatorano@ciemat.e [Ciemat, Laboratorio de Metrologia de Radiaciones Ionizantes, Avda. Complutense 22, Madrid 28040 (Spain); Medina, Virginia Peyres; Roteta Ibarra, Miguel [Ciemat, Laboratorio de Metrologia de Radiaciones Ionizantes, Avda. Complutense 22, Madrid 28040 (Spain)

    2010-07-15

    The half-life of the positron-emitter {sup 18}F has been measured by following the decay rate with three systems: ionization chambers, Ge detectors and coincidence with fast scintillators. The decay rate was measured for periods of time up to 9 half-lives. The combination of the results obtained with the three measuring systems gives a value of T{sub 1/2}=1.82871 (18) h, in good agreement with recommended data and with an estimated uncertainty lower than any other previously reported value.

  17. Improvements in 230Th dating, 230Th and 234U half-life values, and U-Th isotopic measurements by multi-collector inductively coupled plasma mass spectrometry

    Science.gov (United States)

    Cheng, Hai; Lawrence Edwards, R.; Shen, Chuan-Chou; Polyak, Victor J.; Asmerom, Yemane; Woodhead, Jon; Hellstrom, John; Wang, Yongjin; Kong, Xinggong; Spötl, Christoph; Wang, Xianfeng; Calvin Alexander, E.

    2013-06-01

    We have developed techniques for measuring 234U and 230Th on Faraday cups with precisions of 1-3 epsilon units (1 ɛ-unit=1 part in 104) using multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). Using a Thermo-Scientific Neptune with desolvation nebulization, we obtained ionization/transmission efficiencies of 1-2% for both U and Th. We set up protocols to correct for tailing, prepared U and Th gravimetric standards, tested a Th mass fractionation correction procedure based on U isotopes, and identified natural calcite samples likely to be in U-Th isotopic secular equilibrium. The measured atomic ratios, 234U/238U=54.970 (±0.019)×10-6 and 230Th/238U=16.916 (±0.018)×10-6, for these calcite samples were identical within errors (quoted 2σ uncertainties calculated combining all sources of error). Half-life values calculated from these ratios are consistent with previous values, but have much smaller errors: 245,620±260 a for 234U and 75,584±110 a for 230Th (quoted 2σ uncertainties calculated using all sources of error). In calculating a 230Th age, some of the systematic errors included in estimating the full error in the half-lives effectively cancel. Removing these uncertainties (uncertainty in the 238U half-life value, uncertainty in our gravimetric uranium and thorium standards, and uncertainty in the absolute isotopic composition of the uranium standard), yields effective uncertainties for the purposes of 230Th dating of ±70 a for the 234U half-life value and ±30 a for the 230Th half-life value. Under ideal circumstances, with our methods, the 2σ uncertainty in age, including uncertainty in half-life values is ±10 a at 10 ka, ±100 a at 130 ka, ±300 a at 200 ka, ±1 ka at 300 ka, ±2 ka at 400 ka, ±6 ka at 500 ka, and ±12 ka at 600 ka. The isotopic composition of a sample with an age determined independent of the Sanbao Cave ages, the observed co-variation between stalagmite δ18O and Northern Hemisphere summer insolation is

  18. Half-life of samarium-147

    CERN Document Server

    Kinoshita, N; Nakanishi, T

    2003-01-01

    The alpha-decay half-life of sup 1 sup 4 sup 7 Sm has been reevaluated. Known amounts of natural Sm and an alpha-emitter standard ( sup 2 sup 1 sup 0 Po, sup 2 sup 3 sup 8 U, or sup 2 sup 4 sup 1 Am) were mixed well to prepare thin sources for the simultaneous counting of sup 1 sup 4 sup 7 Sm and the alpha-emitter standard by means of an alpha-spectrometer using a silicon surface barrier detector. The alpha-disintegration rate of known amounts of sup 1 sup 4 sup 7 Sm was determined by reference to the alpha activity of the standard. The source preparation and counting were repeated to establish the reproducibility of the present half-life determination, and supplementary alpha spectrometry was carried out by a liquid-scintillation spectrometer. The arithmetic mean of the experimental half-life values was obtained to be (1.17 +- 0.02) x 10 sup 1 sup 1 y. This value is about 10% longer than the currently adopted value, (1.06 +- 0.02) x 10 sup 1 sup 1 y, and the possible factors for this difference are discussed...

  19. Half-life of 51Mn

    Science.gov (United States)

    Graves, Stephen A.; Ellison, Paul A.; Valdovinos, Hector F.; Barnhart, Todd E.; Nickles, Robert J.; Engle, Jonathan W.

    2017-07-01

    The half-life of 51Mn was measured by serial gamma spectrometry of the 511-keV annihilation photon following decay by β+ emission. Data were collected every 100 seconds for 100,000-230,000 seconds within each measurement (n =4 ). The 511-keV incidence rate was calculated from the 511-keV spectral peak area and count duration, corrected for detector dead time and radioactive decay. Least-squares regression analysis was used to determine the half-life of 51Mn while accounting for the presence of background contaminants, notably 55Co. The result was 45.59 ±0.07 min, which is the highest precision measurement to date and disagrees with the current Nuclear Data Sheets value by over 6 σ .

  20. 18F half-life measurement using a high-purity germanium detector.

    Science.gov (United States)

    Han, Jubong; Lee, K B; Park, T S; Lee, J M; Oh, P J; Lee, S H; Kang, Y S; Ahn, J K

    2012-11-01

    The half-life of (18)F has been measured using HPGe detectors with a (137)Cs reference source. The counting ratio of 511 keV γ-rays from (18)F to 622 keV γ-rays from (137)Cs was fitted for the half-life with a weighted least-square method. Uncertainties due to the systematic effects arising from the measurement of a high activity (18)F source were studied in detail. The half-life of (18)F was found to be (109.72±0.19) min. The result is in a good agreement with the recommended value of (109.728±0.019) min evaluated at the Laborotaire National Henri Becquerel (LNHB).

  1. Using gamma distribution to determine half-life of rotenone, applied in freshwater

    Energy Technology Data Exchange (ETDEWEB)

    Rohan, Maheswaran, E-mail: mrohan@aut.ac.nz [Department of Biostatistics and Epidemiology, Auckland University of Technology, Auckland (New Zealand); Fairweather, Alastair; Grainger, Natasha [Science and Capability, Department of Conservation, Hamilton (New Zealand)

    2015-09-15

    Following the use of rotenone to eradicate invasive pest fish, a dynamic first-order kinetic model is usually used to determine the half-life and rate at which rotenone dissipated from the treated waterbody. In this study, we investigate the use of a stochastic gamma model for determining the half-life and rate at which rotenone dissipates from waterbodies. The first-order kinetic and gamma models produced similar values for the half-life (4.45 days and 5.33 days respectively) and days to complete dissipation (51.2 days and 52.48 days respectively). However, the gamma model fitted the data better and was more flexible than the first-order kinetic model, allowing us to use covariates and to predict a possible range for the half-life of rotenone. These benefits are particularly important when examining the influence that different environmental factors have on rotenone dissipation and when trying to predict the rate at which rotenone will dissipate during future operations. We therefore recommend that in future the gamma distribution model is used when calculating the half-life of rotenone in preference to the dynamic first-order kinetics model. - Highlights: • We investigated the use of the gamma model to calculate the half-life of rotenone. • Physical and environmental variables can be incorporated into the model. • A method for calculating the range around a mean half-life is presented. • The model is more flexible than the traditionally used first-order kinetic model.

  2. Experimental determination of the {sup 233}U half-life

    Energy Technology Data Exchange (ETDEWEB)

    Pomme, S.; Altzitzoglou, T.; Van Ammel, R.; Sibbens, G.; Eykens, R.; Richter, S.; Camps, J. [European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (Belgium); Kossert, K.; Janben, H. [Physikalisch-Technische Bundesanstalt (PTB), Braunschweig (Germany); Garcia-Torano, E.; Duran, T. [CIEMAT, Lab. de Metrologia de Radiaciones Ionizantes, Madrid (Spain); Jaubert, F. [CEA Saclay, LNE-LNHB, Lab. National Henri Becquerel 91 - Gif-sur-Yvette (France)

    2009-10-15

    The half-life of {sup 233}U was determined by a specific activity method, in the frame of an international collaboration project of four metrology institutes. A purified, highly enriched {sup 233}U solution was prepared with certified concentration of uranium isotopes. The isotopic composition of the uranium material was determined by thermal ionization mass spectrometry. The ingrowth of daughter nuclides was calculated and confirmed by {alpha}-particle and {gamma}-ray spectrometry measurements. Quantitative sources were prepared from aliquots of the {sup 233}U solution and their disintegration rate was determined by means of {alpha}-particle counting at a defined small solid angle, liquid-scintillation counting and 4{pi} counting in a pressurized proportional counter and in a CsI(Tl) sandwich spectrometer. A half-life value of 1.5867(14) * 10{sup 5} a was obtained, in which the relative standard uncertainty amounts to 0.09%. The result is lower than the currently recommended value of 1.592(2) * 10{sup 5} a and a new best estimate of T(1/2)({sup 233}U) = 1.5903(13) * 10{sup 5} a was calculated from a partially weighted mean of a set of published data. (authors)

  3. A Calorimetric Determination of the Half Life of Polonium-210 (Final Report)

    Energy Technology Data Exchange (ETDEWEB)

    Eichelberger, J. F.; Jordan, K. C.; Orr, S. R.; Parks, J. R.

    1953-02-10

    Six determinations have been made of the half life of polonium with four different steady-state, resistance-bridge calorimeters and five different samples of polonium. These six values of the half life have been weighted and combined to give a grand-mean value of the half life of 138.4005 + - 0.0051 days.

  4. I-Xe systematics of the impact plume produced chondrules from the CB carbonaceous chondrites: Implications for the half-life value of 129I and absolute age normalization of 129I-129Xe chronometer

    Science.gov (United States)

    Pravdivtseva, O.; Meshik, A.; Hohenberg, C. M.; Krot, A. N.

    2017-03-01

    0.6 Ma value for 129I half-life. The slopes of I-Xe - Pb-Pb correlation lines plotted for different sets of samples for Shallowater normalization are always ⩽1. Assuming uranium half-life values are correct; this restricts the half-life of 129I to ⩽15.7 Ma.

  5. 63Ni, its half-life and standardization: revisited.

    Science.gov (United States)

    Collé, R; Zimmerman, B E; Cassette, P; Laureano-Perez, L

    2008-01-01

    Recent liquid scintillation (LS) measurements at the National Institute of Standards and Technology (NIST) and at the Laboratoire National Henri Becquerel (LNHB) on a standardized (63)Ni solution that has been tracked for nearly 40 years have resulted in several important findings: (i) a (63)Ni half-life value of 101.2 +/- 1.5 a has been determined with the present decay data. This value is consistent with a previous specific activity determination and with an earlier value from decay measurements; and it appears to be more satisfactory than a recent data evaluator's recommended value of 98.7 a. (ii) All solution standards of (63)Ni as disseminated by NIST for the past 38(+) years are internally consistent with past and recent standardizations. (iii) Primary LS standardizations of (63)Ni by the triple-to-double coincidence ratio (TDCR) method and by CIEMAT/NIST (3)H-standard efficiency tracing (CNET) appear to be comparable, although the latter methodology is believed to be inherently inferior. (iv) There is excellent measurement agreement between NIST and LNHB for (63)Ni primary standardizations.

  6. Measurement of the half-life of sup 1 sup 7 sup 6 Lu

    CERN Document Server

    Nir-El, Y

    1998-01-01

    The half-life of sup 1 sup 7 sup 6 Lu was determined by measuring the disintegration rate of a solution of lutetium oxide, using a calibrated HPGe detector, and found to be (3.69+-0.02)x10 sup 1 sup 0 y. It is recommended that the current adopted value be calculated from the grouping of three published values since 1983, including our value, the weighted mean of which is (3.73+-0.01)x10 sup 1 sup 0 y.

  7. Effect of parent and daughter deformation on half-life time in exotic decay

    Indian Academy of Sciences (India)

    K P Santhosh; Antony Joseph

    2002-10-01

    Taking Coulomb and proximity potential as interacting barrier for post-scission region we calculated half-life time for different modes of exotic decay treating parent and fragments as spheres and these values are compared with experimental data. We studied the effect of deformation of parent and daughter on half-life time treating emitted cluster as spherical. When deformations are included half-life time values are found to decrease, though slightly. It is found that parent deformation alone will not produce appreciable change in half-life time since it affects relatively small pre-scission part of the barrier.

  8. Effect of parent and daughter deformation on half-life time in exotic decay

    CERN Document Server

    Santhosh, K P

    2002-01-01

    Taking Coulomb and proximity potential as interacting barrier for post-scission region we calculated half-life time for different modes of exotic decay treating parent and fragments as spheres and these values are compared with experimental data. We studied the effect of deformation of parent and daughter on half-life time treating emitted cluster as spherical. When deformations are included half-life time values are found to decrease, though slightly. It is found that parent deformation alone will not produce appreciable change in half-life time since it affects relatively small pre-scission part of the barrier. (author)

  9. Half-life predictions for decay modes of superheavy nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Duarte, S.B.; Tavares, O.A.P. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil); Goncalves, M. [Instituto de Radioprotecao e Dosimetria (IRD), Rio de Janeiro, RJ (Brazil); Rodriguez, O.; Guzman, F. [Instituto Superior de Ciencias e Tecnologia Nucleares (InSTEC), La Habana (Cuba); Barbosa, T.N.; Garcia, F.; Dimarco, A. [Universidade Estadual de Santa Cruz, Ilheus, BA (Brazil). Dept. de Ciencias Exatas e Tecnologicas

    2004-09-01

    We applied the Effective Liquid Drop Model (ELDM) to predict the alpha-decay, cluster emission and cold fission half-life-values of nuclei in the region of Superheavy Elements (SHE). The present calculations have been made in the region of the ZN-plane defined by 155 <=N <=220 and 110<=Z<=135. Shell effects are included via the Q-value of the corresponding decay case. We report the results of a systematic calculation of the half-life for the three nuclear decay modes in a region of the ZN-plane where superheavy elements are expected to be found. Results have shown that, among the decay modes investigated here, the alpha decay is the dominant one. i.e, the decay mode of smallest half-lives. Half-life predictions for alpha decay, cluster emission and cold fission for the isotopic family of the most recent SHE detected of Z=115 and for the isotopic family of the already consolidated SHE of Z=111 are presented. (author)

  10. Determination of (137)Cs half-life with an ionization chamber.

    Science.gov (United States)

    Juget, Frédéric; Nedjadi, Youcef; Buchillier, Thierry; Bochud, François; Bailat, Claude

    2016-12-01

    The half-life of (137)Cs was measured with an ionization chamber by following the decay of 5 sources over a 30 years period between 1983 and 2013. The ratio between the ionization chamber current for the cesium sources and (226)Ra source was used for the half-life calculation. The value found for the (137)Cs half-life is 10,955.2±10.7 days, where the uncertainty evaluation combines type A and B for one standard deviation.

  11. Estimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model

    Directory of Open Access Journals (Sweden)

    Seongil Jo

    2015-07-01

    Full Text Available Methylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 ± 8.6 days. The population mean of the methylmercury half-life was 81.6 ± 8.4 days for men and 78.9 ± 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 ± 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values.

  12. Half-life of Si-32 from tandem-accelerator mass spectrometry

    Science.gov (United States)

    Elmore, D.; Anantaraman, N.; Fulbright, H. W.; Gove, H. E.; Nishiizumi, K.; Murrell, M. T.; Honda, M.; Hans, H. S.

    1980-01-01

    A newly developed mass-spectrometry technique employing a tandem Van de Graaff accelerator together with a special beam-transport system and heavy-ion detector has been used to determine the half-life of Si-32. The result obtained, 108 plus or minus 18 yr, disagrees with the accepted value of 330 plus or minus 40 yr. The implications of the new half-life of Si-32, which is used for dating studies, are discussed.

  13. Determination of the half-life of 213Fr with high precision

    Science.gov (United States)

    Fisichella, M.; Musumarra, A.; Farinon, F.; Nociforo, C.; Del Zoppo, A.; Figuera, P.; La Cognata, M.; Pellegriti, M. G.; Scuderi, V.; Torresi, D.; Strano, E.

    2013-07-01

    High-precision measurement of half-life and Qα value of neutral and highly charged α emitters is a major subject of investigation currently. In this framework, we recently pushed half-life measurements of neutral emitters to a precision of a few per mil. This result was achieved by using different techniques and apparatuses at Istituto Nazionale di Fisica Nucleare Laboratori Nazionali del Sud (INFN-LNS) and GSI Darmstadt. Here we report on 213Fr half-life determination [T1/2(213Fr) = 34.14±0.06 s] at INFN-LNS, detailing the measurement protocol used. Direct comparison with the accepted value in the literature shows a discrepancy of more than three sigma. We propose this new value as a reference, discussing previous experiments.

  14. Three-Laboratory Measurement of the {sup 44}Ti Half-Life

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, I.; Fischer, S.M.; Kutschera, W.; Paul, M. [Physics Division, Argonne National Laboratory, Argonne, Illinois 60439 (United States); Bonino, G.; Bonino, G.; Castagnoli, G.C.; Castagnoli, G.C. [Dipartimento di Fisica Generale dell`Universita, Via P. Giuria 1, I-10125 Torino (Italy); Kutschera, W. [Institut fuer Radiumforschung und Kernphysik der Universitaet Wien, Boltzmanngasse 3, A-1090 Vienna (Austria); Paul, M. [Racah Institute of Physics, Hebrew University, Jerusalem, Israel 91904] [University of Chicago, Chicago, Illinois 60637 (United States)

    1998-03-01

    We report on a measurement of the {sup 44}Ti half-life aimed at lowering existing systematic uncertainties in this value, which is important to astrophysics. The half-life was measured by following the decay of {sup 44}Ti relative to {sup 60}Co for about 5yr and the measurements were performed independently in three laboratories{emdash}Argonne, Jerusalem, and Torino. We suggest to combine our result, 59.0{plus_minus}0.6yr, with the one from the accompanying Letter by G{umlt o}rres {ital et al.,} 60.3{plus_minus}1.3yr, to obtain a current {open_quotes}best value{close_quotes} for the half-life of {sup 44}Ti of 59.2{plus_minus}0.6 yr (1{sigma} error). {copyright} {ital 1998} {ital The American Physical Society}

  15. PEPlife: A Repository of the Half-life of Peptides

    Science.gov (United States)

    Mathur, Deepika; Prakash, Satya; Anand, Priya; Kaur, Harpreet; Agrawal, Piyush; Mehta, Ayesha; Kumar, Rajesh; Singh, Sandeep; Raghava, Gajendra P. S.

    2016-11-01

    Short half-life is one of the key challenges in the field of therapeutic peptides. Various studies have reported enhancement in the stability of peptides using methods like chemical modifications, D-amino acid substitution, cyclization, replacement of labile aminos acids, etc. In order to study this scattered data, there is a pressing need for a repository dedicated to the half-life of peptides. To fill this lacuna, we have developed PEPlife (http://crdd.osdd.net/raghava/peplife), a manually curated resource of experimentally determined half-life of peptides. PEPlife contains 2229 entries covering 1193 unique peptides. Each entry provides detailed information of the peptide, like its name, sequence, half-life, modifications, the experimental assay for determining half-life, biological nature and activity of the peptide. We also maintain SMILES and structures of peptides. We have incorporated web-based modules to offer user-friendly data searching and browsing in the database. PEPlife integrates numerous tools to perform various types of analysis such as BLAST, Smith-Waterman algorithm, GGSEARCH, Jalview and MUSTANG. PEPlife would augment the understanding of different factors that affect the half-life of peptides like modifications, sequence, length, route of delivery of the peptide, etc. We anticipate that PEPlife will be useful for the researchers working in the area of peptide-based therapeutics.

  16. Re-measurement of the half-life of sup 7 sup 9 Se

    CERN Document Server

    Jiang Song Sheng; Diao Li Jun; Li Chun Shen; GouJingRu; Wu Shao Yon

    2002-01-01

    A new attempt has been made for the re-measurement of the half-life of sup 7 sup 9 Se. We made two major improvements over our earlier sup 7 sup 9 Se half-life determination (Nucl. Instr. and Meth. B 123 (1997) 403). Firstly, the half-life of sup 7 sup 9 Se was measured relative to the precisely known half-life of sup 7 sup 5 Se, rather than an absolute measurement of sup 7 sup 9 Se/Se. Secondly, the Projectile X-ray Detection technique was used for the separation of sup 7 sup 9 Se from its isobar, sup 7 sup 9 Br, rather than measuring sup 8 sup 1 Br for the deduction of sup 7 sup 9 Br interference, and this technique was also used for separation of sup 7 sup 5 Se and its isobar, sup 7 sup 5 As. A detailed description of the sample preparations, experimental setup and measurements are given. The re-measured half-life of sup 7 sup 9 Se was (2.95+-0.38)x10 sup 5 a, about a factor of 3 lower than the previous value, 1.1x10 sup 6 a. The problems in the previous measurement are discussed.

  17. Measurement of the half-life of sup 7 sup 9 Se with PX-AMS

    CERN Document Server

    He Ming; Jiang Shan; Diao Li Jun; Wu Shao Yon; Li Chun Shen

    2002-01-01

    The half-life of sup 7 sup 9 Se has been re-measured with projectile X-rays detection (PXD) in accelerator mass spectrometry after a new PXD system had been set up in China Institute of Atomic Energy (CIAE). The PXD technique has been used for separation of sup 7 sup 9 Se from its isobar, sup 7 sup 9 Br. The detection efficiency of sup 7 sup 9 Se K subalpha X-rays is obtained from that of sup 8 sup 0 Se after energy correction. The atom number of sup 7 sup 9 Se in each sample is deduced from the measured ratios of sup 7 sup 9 Se/Se. From the measured decay rates of each sample, the half-life is deduced to be (2.80+-0.36)x10 sup 5 a. In order to check the reliability of the result of sup 7 sup 9 Se half-life, the sup 7 sup 5 Se half-life is also measured with PX-AMS method. The measured half-life of sup 7 sup 5 Se is in good agreement with well-known literature value.

  18. $\\beta$-Decay Half-Life of the $rp$-Process Waiting Point Nuclide $^{84}$Mo

    CERN Document Server

    Stoker, J B; Bazin, D; Becerril, A; Berryman, J S; Crawford, H L; Estrade, A; Guess, C J; Hitt, G W; Lorusso, G; Matos, M; Minamisono, K; Montes, F; Pereira, J; Perdikakis, G; Schatz, H; Smith, K; Zegers, R G T

    2009-01-01

    A half-life of 2.2 $\\pm$ 0.2 s has been deduced for the ground-state $\\beta$ decay of $^{84}$Mo, more than 1$\\sigma$ shorter than the previously adopted value. $^{84}$Mo is an even-even N = Z nucleus lying on the proton dripline, created during explosive hydrogen burning in Type I X-ray bursts in the rapid proton capture ($rp$) process. The effect of the measured half-life on $rp$-process reaction flow is explored. Implications on theoretical treatments of nuclear deformation in $^{84}$Mo are also discussed.

  19. A New Value of 93Zr Half-Life

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>93Zr is a long-lived pure β emitter with energies of 60.6 keV (97.5%) and 91.4 keV (2.5%). It is produced by both nuclear fission and neutron capture of 92Zr. 93Zr has considerable attention because of its

  20. Beta Decay Half-Life of 84Mo

    Science.gov (United States)

    Stoker, J. B.; Mantica, P. F.; Bazin, D.; Bickley, A.; Becerril, A.; Crawford, H.; Cruse, K.; Estrade, A.; Mosby, M.; Guess, C. J.; Hitt, G. W.; Lorusso, G.; Matos, M.; Meharchand, R.; Minamisono, K.; Montes, F.; Pereira, J.; Perdikakis, G.; Pinter, J. S.; Schatz, H.; Vredevoogd, J.; Zegers, R. G. T.

    2008-10-01

    The β-decay half-life ^84Mo governs leakage out of the Zr-Nb cycle, a high temperature rp-process endpoint in x-ray binaries [1]. Treatment of the background and the poor statistics accumulated during the previous half-life measurement leave questions about statistical and systematic errors. We have remeasured the half-life of ^84Mo using a concerted setup of the NSCL β-Counting System [3] and 16 detectors from the Segmented Germanium Array [4]. We will report the half-life for ^84Mo, deduced using 40 times the previous sample size. The application of the NSCL RF Fragment Separator to remove unwanted isotopes, and hence reduce background for the half-life measurement, will also be discussed. [1] H. Schatz et al., Phys. Rep. 294, 167 1998 [2] P. Kienle et al., Prog. Part. Nuc. Phys. 46, 73 2001 [3] J. Prisciandaro et al., NIM A 505, 140 2003 [4] W. Mueller et al., NIM A 466, 492 2001 [5] D. Gorelov et al. PAC 2005, Knoxville, TN, May 16-20

  1. Determination of the {sup 151}Sm half-life

    Energy Technology Data Exchange (ETDEWEB)

    Be, Marie-Martine; Cassette, Philippe [CEA, LIST, Gif sur Yvette (France). LNE-Laboratoire National Henri Becquerel; Isnard, Helene [CEA-LANIE, Gif sur Yvette (France); and others

    2015-07-01

    New measurements have been undertaken to determine the half-life of {sup 151}Sm. A pure {sup 151}Sm solution was obtained after chemical separation from a samarium solution resulting from the dissolution of an irradiated samarium sample. The concentration of {sup 151}Sm in the solution was measured by mass spectrometry, combined with the isotope dilution technique. The activity of the solution was measured by liquid scintillation counting by six European laboratories as part of an international comparison. These combined results lead to a half-life of T{sub 1/2} = 94.6(6)a.

  2. Half-life and inner penetrability in the cold fission of {sup 248}Cm

    Energy Technology Data Exchange (ETDEWEB)

    Kunhikrishnan, P.V. [Sree Narayana College, Department of Physics, Kannur (India); Santhosh, K.P. [Kannur University, School of Pure and Applied Physics, Payyanur (India); Joseph, Antony [University of Calicut, Department of Physics, Malappuram, Kerala (India)

    2012-06-15

    Using the Coulomb and proximity potential model (CPPM) with the nuclear surface tension improved by Reisdorf, the various fragmentations in the cold fission of {sup 248}Cm are studied as a cluster decay process within a fission model. The computed half-life values are compared with the values reported by Sandulescu et al. using the double-folding M3Y nuclear-nuclear potential model and are in agreement with CPPM values. The diffuseness width used in the proximity potential is found to be sensitive to the half-life. The inner penetrability is computed based on the formalism of Poenaru et al. (J. Phys. G: Nucl. Part. Phys. 17, 443 (1991)) and found that in the cold fission the contribution of the inner part (overlap region) of the barrier is significant compared to cluster decays. The variation of the inner penetrability with fragment mass is studied which emphasizes the fact that cold fission is an extension of cluster decay. (orig.)

  3. Superior serum half life of albumin tagged TNF ligands

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Nicole [Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wuerzburg, Roentgenring 11, 97070 Wuerzburg (Germany); Schneider, Britta; Pfizenmaier, Klaus [Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, 70569 Stuttgart (Germany); Wajant, Harald, E-mail: harald.wajant@mail.uni-wuerzburg.de [Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wuerzburg, Roentgenring 11, 97070 Wuerzburg (Germany)

    2010-06-11

    Due to their immune stimulating and apoptosis inducing properties, ligands of the TNF family attract increasing interest as therapeutic proteins. A general limitation of in vivo applications of recombinant soluble TNF ligands is their notoriously rapid clearance from circulation. To improve the serum half life of the TNF family members TNF, TWEAK and TRAIL, we genetically fused soluble variants of these molecules to human serum albumin (HSA). The serum albumin-TNF ligand fusion proteins were found to be of similar bioactivity as the corresponding HSA-less counterparts. Upon intravenous injection (i.v.), serum half life of HSA-TNF ligand fusion proteins, as determined by ELISA, was around 15 h as compared to approximately 1 h for all of the recombinant control TNF ligands without HSA domain. Moreover, serum samples collected 6 or 24 h after i.v. injection still contained high TNF ligand bioactivity, demonstrating that there is only limited degradation/inactivation of circulating HSA-TNF ligand fusion proteins in vivo. In a xenotransplantation model, significantly less of the HSA-TRAIL fusion protein compared to the respective control TRAIL protein was required to achieve inhibition of tumor growth indicating that the increased half life of HSA-TNF ligand fusion proteins translates into better therapeutic action in vivo. In conclusion, our data suggest that genetic fusion to serum albumin is a powerful and generally applicable mean to improve bioavailability and in vivo activity of TNF ligands.

  4. Precise Half-Life Measurement of the Superallowed beta emitter 10C

    CERN Document Server

    Iacob, V E; Golovko, V; Goodwin, J; Nica, N; Park, H I; Trache, L; Tribble, R E

    2007-01-01

    The half-life of 10C has been measured to be 19.310(4)s, a result with 0.02% precision, which is a factor of three improvement over the best previous result. Since 10C is the lightest superallowed 0+ --> 0+ beta emitter, its ft value has the greatest weight in setting an upper limit on the possible presence of scalar currents.

  5. Precision half-life measurement of the 4-fold forbidden β decay of V50

    Science.gov (United States)

    Dombrowski, H.; Neumaier, S.; Zuber, K.

    2011-05-01

    A sensitive search of the 4-fold forbidden nonunique decay of V50 has been performed. A total mass measuring time product of 186 kg d has been accumulated. A reliable half-life value with the highest precision so far of (2.29±0.25)×1017 years of the electron capture decay of V50 into the first excited state of Ti50 could be obtained. A photon emission line following the β decay into the first excited state of Cr50 could not be observed, resulting in a lower limit on the half-life of the β-decay branch of 1.7×1018 years. This is not in good agreement with a claimed observation of this decay branch published in 1989.

  6. Measurement of the 135Cs half-life with accelerator mass spectrometry and inductively coupled plasma mass spectrometry

    Science.gov (United States)

    MacDonald, C. M.; Cornett, R. J.; Charles, C. R. J.; Zhao, X. L.; Kieser, W. E.

    2016-01-01

    The isotope 135Cs is quoted as having a half-life of 2.3 Myr. However, there are three published values ranging from 1.8 to 3 Myr. This research reviews previous measurements and reports a new measurement of the half-life using newly developed accelerator mass spectrometry (AMS) and inductively coupled plasma mass spectrometry (ICPMS) techniques along with β and γ radiometric analysis. The half-life was determined to be (1.6 ±0.6 ) ×106 yr by AMS and (1.3 ±0.2 ) ×106 yr by ICPMS with 95% confidence. The two values agree with each other but differ from the accepted value by ˜40 % .

  7. A shorter 146Sm half-life measured and implications for 146Sm-142Nd chronology in the solar system.

    Science.gov (United States)

    Kinoshita, N; Paul, M; Kashiv, Y; Collon, P; Deibel, C M; DiGiovine, B; Greene, J P; Henderson, D J; Jiang, C L; Marley, S T; Nakanishi, T; Pardo, R C; Rehm, K E; Robertson, D; Scott, R; Schmitt, C; Tang, X D; Vondrasek, R; Yokoyama, A

    2012-03-30

    The extinct p-process nuclide (146)Sm serves as an astrophysical and geochemical chronometer through measurements of isotopic anomalies of its α-decay daughter (142)Nd. Based on analyses of (146)Sm/(147)Sm α-activity and atom ratios, we determined the half-life of (146)Sm to be 68 ± 7 (1σ) million years, which is shorter than the currently used value of 103 ± 5 million years. This half-life value implies a higher initial (146)Sm abundance in the early solar system, ((146)Sm/(144)Sm)(0) = 0.0094 ± 0.0005 (2σ), than previously estimated. Terrestrial, lunar, and martian planetary silicate mantle differentiation events dated with (146)Sm-(142)Nd converge to a shorter time span and in general to earlier times, due to the combined effect of the new (146)Sm half-life and ((146)Sm/(144)Sm)(0) values.

  8. Precise Half-Life Measurement of the Superallowed Beta+ Emitter 46V

    CERN Document Server

    Park, H I; Iacob, V E; Chen, L; Goodwin, J; Nica, N; Simmons, E; Trache, L; Tribble, R E

    2011-01-01

    The half-life of 46V has been measured to be 422.66(6) ms, which is a factor of two more precise than the best previous measurement. Our result is also consistent with the previous measurements, with no repeat of the disagreement recently encountered with Q_{EC} values measured for the same transition. The Ft value for the 46V superallowed transition, incorporating all world data, is determined to be 3074.1(26) s, a result consistent with the average Ft value of 3072.08(79) s established from the 13 best-known superallowed transitions.

  9. PEGylation of antibody fragments for half-life extension.

    Science.gov (United States)

    Jevševar, Simona; Kusterle, Mateja; Kenig, Maja

    2012-01-01

    Antibody fragments (Fab's) represent important structure for creating new therapeutics. Compared to full antibodies Fab' fragments possess certain advantages, including higher mobility and tissue penetration, ability to bind antigen monovalently and lack of fragment crystallizable (Fc) region-mediated functions such as antibody-dependent cell mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). The main drawback for the use of Fab's in clinical applications is associated with their short half-life in vivo, which is a consequence of no longer having the Fc region. To exert meaningful clinical effects, the half-life of Fab's need to be extended, which has been achieved by postproduction chemical attachment of polyethylene glycol (PEG) chain to protein using PEGylation technology. The most suitable approach employs PEG-maleimide attachment to cysteines, either to the free hinge cysteine or to C-terminal cysteines involved in interchain disulfide linkage of the heavy and light chain. Hence, protocols for mono-PEGylation of Fab via free cysteine in the hinge region and di-PEGylation of Fab via interchain disulfide bridge are provided in this chapter.

  10. New evaluation of alpha decay half-life of {sup 190}Pt isotope for the Pt-Os dating system

    Energy Technology Data Exchange (ETDEWEB)

    Tavares, O.A.P.; Medeiros, E.L. [Centro Brasileiro de Pesquisas Fisicas (CBPF), Rio de Janeiro, RJ (Brazil); Terranova, M.L. [Universita degli Studi di Roma Tor Vergata (Italy). Dipt. di Scienze e Tecnologie Chimiche; Istituto Nazionale di Fisica Nucleare (INFN), Rome (Italy)

    2005-08-15

    A semiempirical model based on the quantum mechanical tunnelling mechanism of alpha emission from nuclei has been used to evaluate the half-life of the Pt isotopes. For the important naturally occurring {sup 190}Pt isotope, the radiogenic parent in the {sup 190} Pt {yields} {sup 186}Os dating system, the model yielded a half-life value of (3.7{+-} 0.3) versus 10{sup 11} y. This is comparable to (3.2{+-}0.1) versus 10{sup 11} y which was obtained in the last direct counting experiment to measure the alpha activity of {sup 190}Pt (Tavares and Terranova, Rad. Measurem. 27 (1997) 19). A literature survey of available alpha decay half-life values for {sup 190}Pt isotope is also reported. The significant discrepancies found between data obtained by direct counting, indirect geological methods and different calculation models are analysed and discussed. (author)

  11. Determination of the half-life of sup 1 sup 0 sup 5 sup m Rh

    CERN Document Server

    Kronenberg, A K; Weber, R; Esterlund, R A; Patzelt, P

    1998-01-01

    Following a fast chemical separation of Ru isotopes from a fission-product mixture, sup 1 sup 0 sup 5 sup m Rh was periodically extracted from its precursor (4.44-h sup 1 sup 0 sup 5 Ru) for measurements of its half-life. The new value for the T sub 1 sub / sub 2 of sup 1 sup 0 sup 5 sup m Rh of (43.0+-0.3) s resolves the long-standing conflict in the literature between the two earlier measured values of 45 and 30 s.

  12. CODATA Recommended Values of the Fundamental Physical Constants: 2014*

    Science.gov (United States)

    Mohr, Peter J.; Newell, David B.; Taylor, Barry N.

    2016-12-01

    This paper gives the 2014 self-consistent set of values of the constants and conversion factors of physics and chemistry recommended by the Committee on Data for Science and Technology (CODATA). These values are based on a least-squares adjustment that takes into account all data available up to 31 December 2014. Details of the data selection and methodology of the adjustment are described. The recommended values may also be found at http://physics.nist.gov/constants.

  13. CODATA Recommended Values of the Fundamental Physical Constants: 2014

    CERN Document Server

    Mohr, Peter J; Taylor, Barry N

    2015-01-01

    This report gives the 2014 self-consistent set of values of the constants and conversion factors of physics and chemistry recommended by the Committee on Data for Science and Technology (CODATA). These values are based on a least-squares adjustment that takes into account all data available up to 31 December 2014. The recommended values may also be found on the World Wide Web at physics.nist.gov/constants.

  14. β-decay half-life of the rp-process waiting-point nuclide Mo84

    Science.gov (United States)

    Stoker, J. B.; Mantica, P. F.; Bazin, D.; Becerril, A.; Berryman, J. S.; Crawford, H. L.; Estrade, A.; Guess, C. J.; Hitt, G. W.; Lorusso, G.; Matos, M.; Minamisono, K.; Montes, F.; Pereira, J.; Perdikakis, G.; Schatz, H.; Smith, K.; Zegers, R. G. T.

    2009-01-01

    A half-life of 2.2 ± 0.2 s has been deduced for the ground-state β decay of Mo84, more than 1σ shorter than the previously adopted value. Mo84 is an even-even N=Z nucleus lying on the proton dripline, created during explosive hydrogen burning in type I x-ray bursts in the rapid proton capture (rp) process. The effect of the measured half-life on rp-process reaction flow is explored. Implications on theoretical treatments of nuclear deformation in Mo84 are also discussed.

  15. Half-life determination for {sup 108}Ag and {sup 110}Ag

    Energy Technology Data Exchange (ETDEWEB)

    Zahn, Guilherme S.; Genezini, Frederico A. [Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP, P.O. Box 11049, São Paulo, 05422-970 (Brazil)

    2014-11-11

    In this work, the half-life of the short-lived silver radionuclides {sup 108}Ag and {sup 110}Ag were measured by following the activity of samples after they were irradiated in the IEA-R1 reactor. The results were then fitted using a non-paralizable dead time correction to the regular exponential decay and the individual half-life values obtained were then analyzed using both the Normalized Residuals and the Rajeval techniques, in order to reach the most exact and precise final values. To check the validity of dead-time correction, a second correction method was also employed by means of counting a long-lived {sup 60}Co radioactive source together with the samples as a livetime chronometer. The final half-live values obtained using both dead-time correction methods were in good agreement, showing that the correction was properly assessed. The results obtained are partially compatible with the literature values, but with a lower uncertainty, and allow a discussion on the last ENSDF compilations' values.

  16. Gamma-spectrometric determination of the sup 8 sup 9 Sr isotope half-life

    CERN Document Server

    Popov, Y S; Markushin, M N; Kupriyanov, V N; Timofeev, G A

    2002-01-01

    Using the method of semiconductor [Ge(Li)-detector] gamma-spectroscopy by the results of measurements of 913 keV ( sup 8 sup 9 Sr) gamma-line intensity for 6000 h, using as internal reference the 661.7 keV ( sup 1 sup 3 sup 7 Cs) gamma-line, the value of sup 8 sup 9 Sr isotope half-life has been calculated, which proved to be 1208+-9 h or 50.34+-0.37 days. Error is provided for confidential probability P = 0.95

  17. Semi-empirical formula for spontaneous fission half life time

    Energy Technology Data Exchange (ETDEWEB)

    Santhosh, K.P., E-mail: drkpsanthosh@gmail.co [School of Pure and Applied Physics, Kannur University, Payyanur Campus 670 327 (India); Biju, R.K.; Sahadevan, Sabina [P G Department of Physics and Research Centre, Payyanur College, Payyanur 670 327 (India)

    2010-01-15

    A new semi-empirical formula is proposed for determining the spontaneous fission half lives, which works well for the mass region from {sup 232}Th to {sup 286}114. The computed spontaneous fission half life times are also compared with other semi-empirical formula predictions. The alpha decay half lives are systematically computed for heavy and super heavy region with proton numbers varying from 90<=Z<=122 using Coulomb and Proximity Potential Model. The comparison between computed alpha decay half lives and the present spontaneous fission semi-empirical formula predictions of even-even isotopes with Z=90-122 are studied. It is found that in super heavy region the isotopes {sup 270-274}Ds, {sup 272-278}112, {sup 272-282}114, {sup 274-292}116, {sup 276-298}118, {sup 276-308}120 and {sup 278-314}122 will survive fission and can be synthesized and identified via alpha decay.

  18. Determination of half-life and photon emission probabilities of (65)Zn.

    Science.gov (United States)

    Luca, Aurelian; Amiot, Marie-Noëlle; Morel, Jean

    2003-05-01

    A (65) Zn radioactive solution standardized by an absolute measurement method at Laboratoire National Henri Becquerel (LNHB), was sent to Bureau International des Poids et Mesures (BIPM), in order to include the results in their database. The activity value determined at BIPM was in good agreement with that stated by LNHB (the difference was 0.3%). Additional measurements of (65) Zn activity and half-life were also carried out, by using a 4pigamma ionization chamber; the half-life value proposed by this work: 244.15 (10) days, is consistent to others reported in the literature. The spectra analysis was performed by gamma-ray spectrometry with high-purity germanium detectors, with the aim to improve the accuracy of the photon emission probabilities values of this nuclide. The determined photon emission probabilities are 0.498 for the 1115 ke V gamma-ray, 0.347 and 0.0479 for the X-rays Cu-K(alpha) and Cu-K(beta); the associated uncertainties are 0.4%, 0.9% and 1.1%, respectively.

  19. Estimating the biological half-life for radionuclides in homoeothermic vertebrates: a simplified allometric approach

    Energy Technology Data Exchange (ETDEWEB)

    Beresford, N.A. [Lancaster Environment Centre, NERC Centre for Ecology and Hydrology, Lancaster (United Kingdom); Vives i Batlle, J. [Belgian Nuclear Research Centre, Mol (Belgium)

    2013-11-15

    The application of allometric, or mass-dependent, relationships within radioecology has increased with the evolution of models to predict the exposure of organisms other than man. Allometry presents a method of addressing the lack of empirical data on radionuclide transfer and metabolism for the many radionuclide-species combinations which may need to be considered. However, sufficient data across a range of species with different masses are required to establish allometric relationships and this is not always available. Here, an alternative allometric approach to predict the biological half-life of radionuclides in homoeothermic vertebrates which does not require such data is derived. Biological half-life values are predicted for four radionuclides and compared to available data for a range of species. All predictions were within a factor of five of the observed values when the model was parameterised appropriate to the feeding strategy of each species. This is an encouraging level of agreement given that the allometric models are intended to provide broad approximations rather than exact values. However, reasons why some radionuclides deviate from what would be anticipated from Kleiber's law need to be determined to allow a more complete exploitation of the potential of allometric extrapolation within radioecological models. (orig.)

  20. Precise measurement of the 222Rn half-life: A probe to monitor the stability of radioactivity

    Directory of Open Access Journals (Sweden)

    E. Bellotti

    2015-04-01

    Full Text Available We give the results of a study on the 222Rn decay we performed in the Gran Sasso Laboratory (LNGS by detecting the gamma rays from the radon progeny. The motivation was to monitor the stability of radioactivity measuring several times per year the half-life of a short lifetime (days source instead of measuring over a long period the activity of a long lifetime (tens or hundreds of years source. In particular, we give a possible reason of the large periodical fluctuations in the count rate of the gamma rays due to radon inside a closed canister which has been described in literature and which has been attributed to a possible influence of a component in the solar irradiation affecting the nuclear decay rates. We then provide the result of four half-life measurements we performed underground at LNGS in the period from May 2014 to January 2015 with radon diffused into olive oil. Briefly, we did not measure any change of the 222Rn half-life with a 8⋅10−5 precision. Finally, we provide the most precise value for the 222Rn half-life: 3.82146(16stat(4syst days.

  1. Alpha-decay half-life semiempirical relationships with self-improving parameters

    Energy Technology Data Exchange (ETDEWEB)

    Poenaru, D.N.; Ivascu, M.; Mazilu, D. (Institutul Central de Fizica, Bucharest (Romania))

    1982-03-01

    From the alpha decay Q-values, the partial half-life T is estimated by using five semiempirical relationships. The parameters of these formulae have been obtained from a fit with a given set of experimental data on four groups of alpha emitters: even-even, even-odd, odd-even and odd-odd. For each nuclide only the strongest transition is considered and the data are automatically sorted into the four groups mentioned above. There are three options: one can use either the present set of parameter values, a new one given as input data, or new values computed by using a better set of experimental data (more accurate or more complete). For each group of nuclides, up to 8 (or 9) families of curves could be plotted, optionally, with the line printer.

  2. Precise Half-Life Measurement of the Superallowed Beta+ Emitter 26Si

    CERN Document Server

    Iacob, V E; Banu, A; Chen, L; Golovko, V V; Goodwin, J; Horvat, V; Nica, N; Park, H I; Trache, L; Tribble, R E

    2010-01-01

    We have measured the half-life of the superallowed 0+ -to- 0+ beta+ emitter 26Si to be 2245.3(7) ms. We used pure sources of 26Si and employed a high-efficiency gas counter, which was sensitive to positrons from both this nuclide and its daughter 26mAl. The data were analyzed as a linked parent-daughter decay. To contribute meaningfully to any test of the unitarity of the Cabibbo-Kobayashi-Maskawa (CKM) matrix, the ft value of a superallowed transition must be determined to a precision of 0.1% or better. With a precision of 0.03% the present result is more than sufficient to be compatable with that requirement. Only the branching ratio now remains to be measured precisely before a +/-0.1% ft value can be obtained for the superallowed transition from 26Si.

  3. Precise half-life measurements for $^{38}$Ca and $^{39}$Ca

    CERN Document Server

    Blank, B; Demonchy, C-E; Borge, M J G; Matea, I; Munoz, F; Huikari, J; Dominguez-Reyes, R; Plaisir, C; Sturm, S; Canchel, G; Delahaye, P; Audirac, L; Fraile, L M; Serani, L; Lunney, D; Pedroza, J-L; Bey, A; Souin, J; Hui, Tran Trong; Delalee, F; Tengblad, O; Wenander, F

    2010-01-01

    The half-lives of Ca-38 and Ca-39 have been measured at ISOLDE of CERN. The REXTRAP facility was used to prepare ultra-clean samples of radioactive nuclei for precision decay spectroscopy. Ca-38 is one of the T-z = -1, 0(+). 0(+) beta-emitting nuclides used to determine the vector coupling constant of the weak interaction and the V-ud quark-mixing matrix element. The result obtained, T-1/2 = 443.8(19) ms, is four times more precise than the average of previous measurements. For Ca-39, a half-life of T-1/2 = 860.7(10) ms is obtained, a result in agreement with the average value from the literature.

  4. CODATA Recommended Values of the Fundamental Physical Constants: 2010

    CERN Document Server

    Mohr, Peter J; Newell, David B

    2012-01-01

    This paper gives the 2010 self-consistent set of values of the basic constants and conversion factors of physics and chemistry recommended by the Committee on Data for Science and Technology (CODATA) for international use. The 2010 adjustment takes into account the data considered in the 2006 adjustment as well as the data that became available from 1 January 2007, after the closing date of that adjustment, until 31 December 2010, the closing date of the new adjustment. Further, it describes in detail the adjustment of the values of the constants, including the selection of the final set of input data based on the results of least-squares analyses. The 2010 set replaces the previously recommended 2006 CODATA set and may also be found on the World Wide Web at physics.nist.gov/constants.

  5. Precision measurement of the half-life and the decay branches of Ga-62

    NARCIS (Netherlands)

    Canchel, G; Blank, B; Chartier, N; Delalee, F; Dendooven, P; Dossat, C; Giovinazzo, J; Huikari, J; Lalleman, AS; Jimenez, MJL; Madec, [No Value; Pedroza, JL; Penttila, H

    2005-01-01

    In an experiment performed at the Accelerator Laboratory of the University of Jyvaskyla, the beta-decay half-life of Ga-62 has been studied with high precision rising the IGISOL technique. A half-life of T-1/2 = 116.09(17) ms was nieasured. Using beta-gamma coincidences, the gamma intensity of the 9

  6. Static and dynamic half-life and lifetime molecular turnover of enzymes.

    Science.gov (United States)

    Miyawaki, Osato; Kanazawa, Tsukasa; Maruyama, Chika; Dozen, Michiko

    2017-01-01

    The static half-life of an enzyme is the half-life of a free enzyme not working without substrate and the dynamic half-life is that of an active enzyme working with plenty amount of substrate. These two half-lives were measured and compared for glucoamylase (GA) and β-galactosidase (BG). The dynamic half-life was much longer than the static half-life by one to three orders of magnitude for both enzymes. For BG, the half-life of the enzyme physically entrapped in a membrane reactor was also measured. In this case also, the half-life of BG in the membrane reactor was much longer than the free enzyme without substrate. These results suggest the large difference in stabilities between the free enzyme and the enzyme-substrate complex. This may be related to the natural enzyme metabolism. According to the difference in half-life, the lifetime molecular turnover (LMT), which is the number of product molecules produced by a single molecule of enzyme until it loses its activity completely, was much higher by one to four orders of magnitude for the active enzyme than the free enzyme. The concept of LMT, proposed here, will be important in bioreactor operations with or without immobilization. Copyright © 2016 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  7. Activity measurement of 60Fe through the decay of 60mCo and confirmation of its half-life

    CERN Document Server

    Ostdiek, Karen; Bauder, William; Bowers, Matthew; Clark, Adam; Collon, Philippe; Dressler, Rugard; Greene, John; Kutschera, Walter; Lu, Wenting; Nelson, Austin; Paul, Michael; Robertson, Daniel; Schumann, Dorothea; Skulski, Michael

    2016-01-01

    The half-life of the neutron-rich nuclide, $^{60}\\text{Fe}$ has been in dispute in recent years. A measurement in 2009 published a value of $(2.62 \\pm 0.04)\\times10^{6}$ years, almost twice that of the previously accepted value from 1984 of $(1.49 \\pm 0.27)\\times10^{6}$ years. This longer half-life was confirmed in 2015 by a new measurement, resulting in a value of $(2.50 \\pm 0.12)\\times10^{6}$ years. All three half-life measurements used the grow-in of the $\\gamma$-ray lines in $^{60}\\text{Ni}$ from the decay of the ground state of $^{60\\text{g}}\\text{Co}$ (t$_{1/2}$=5.27 years) to determine the activity of a sample with a known number of $^{60}\\text{Fe}$ atoms. In contrast, the work presented here measured the $^{60}\\text{Fe}$ activity directly with the 58.6 keV $\\gamma$-ray line from the short-lived isomeric state of $^{60\\text{m}}\\text{Co}$ (t$_{1/2}$=10.5 minutes), thus being independent of any possible contamination from long-lived $^{60\\text{g}}\\text{Co}$. A fraction of the material from the 2015 exper...

  8. Comparison of serum immunoglobulin G half-life in dairy calves fed colostrum, colostrum replacer or administered with intravenous bovine plasma.

    Science.gov (United States)

    Murphy, Jacob M; Hagey, Jill V; Chigerwe, Munashe

    2014-04-15

    In calves, passive immunity of immunoglobulins can be acquired through ingestion of colostrum or colostrum replacers. Plasma can been used to supplement immunoglobulins in healthy or sick calves. Serum half-life of colostral derived immuglobulin G (IgG) is estimated to be 20 days. Half-life of IgG is important in determining response to antigens and timing of vaccination in calves. To date studies evaluating half-life of colostrum replacer or plasma derived IgG are lacking. The objectives of this study were to compare the serum half-life of IgG derived from colostrum, colostrum replacer and plasma in dairy calves reared up to 35 days of age. Thirty Jersey calves were randomly assigned to receive colostrum or colostrum replacer by oroesophageal tubing or plasma by intravenous administration. Serum samples were collected at 2, 5, 7, 10, 14, 21, 28 and 35 days. Serum IgG concentrations were determined by radial immunodiffusion. The results indicated that half-life for IgG in colostrum fed (28.5 days) or plasma transfused calves (27.3 days) was longer than colostrum replacer fed calves (19.1 days). Further studies are required to evaluate pathogen specific immunoglobulins in order to recommend vaccination timing in calves fed colostrum replacers.

  9. Stable isotope turnover and half-life in animal tissues: a literature synthesis.

    Science.gov (United States)

    Vander Zanden, M Jake; Clayton, Murray K; Moody, Eric K; Solomon, Christopher T; Weidel, Brian C

    2015-01-01

    Stable isotopes of carbon, nitrogen, and sulfur are used as ecological tracers for a variety of applications, such as studies of animal migrations, energy sources, and food web pathways. Yet uncertainty relating to the time period integrated by isotopic measurement of animal tissues can confound the interpretation of isotopic data. There have been a large number of experimental isotopic diet shift studies aimed at quantifying animal tissue isotopic turnover rate λ (%·day(-1), often expressed as isotopic half-life, ln(2)/λ, days). Yet no studies have evaluated or summarized the many individual half-life estimates in an effort to both seek broad-scale patterns and characterize the degree of variability. Here, we collect previously published half-life estimates, examine how half-life is related to body size, and test for tissue- and taxa-varying allometric relationships. Half-life generally increases with animal body mass, and is longer in muscle and blood compared to plasma and internal organs. Half-life was longest in ecotherms, followed by mammals, and finally birds. For ectotherms, different taxa-tissue combinations had similar allometric slopes that generally matched predictions of metabolic theory. Half-life for ectotherms can be approximated as: ln (half-life) = 0.22*ln (body mass) + group-specific intercept; n = 261, plife can be approximated using simple allometric relationships for some taxa and tissue types, there is also a high degree of unexplained variation in our models. Our study highlights several strong and general patterns, though accurate prediction of isotopic half-life from readily available variables such as animal body mass remains elusive.

  10. Precise measurement of the 222Rn half-life: a probe to monitor the stability of radioactivity

    CERN Document Server

    Bellotti, E; Di Carlo, G; Laubenstein, M; Menegazzo, R

    2015-01-01

    We give the results of a study on the 222Rn decay we performed in the Gran Sasso Laboratory (LNGS) by detecting the gamma rays from the radon progeny. The motivation was to monitor the stability of radioactivity measuring several times per year the half-life of a short lifetime (days) source instead of measuring over a long period the activity of a long lifetime (tens or hundreds of years) source. In particular, we give the reason of the large periodical fluctuations in the count rate of the gamma rays due to radon inside a closed canister which has been described in literature and which has been attributed to a possible influence of a component in the solar irradiation affecting the nuclear decay rates. We then provide the result of four half-life measurements we performed underground at LNGS in the period from May 2014 to January 2015 with radon diffused into olive oil. Briefly, we did not measure any change of the 222Rn half-life with a 8*10^-5 precision. Finally, we provide the most precise value for the ...

  11. Recommended values of clean metal surface work functions

    Energy Technology Data Exchange (ETDEWEB)

    Derry, Gregory N., E-mail: gderry@loyola.edu; Kern, Megan E.; Worth, Eli H. [Department of Physics, Loyola University Maryland, 4501 N. Charles St., Baltimore, Maryland 21210 (United States)

    2015-11-15

    A critical review of the experimental literature for measurements of the work functions of clean metal surfaces of single-crystals is presented. The tables presented include all results found for low-index crystal faces except cases that were known to be contaminated surfaces. These results are used to construct a recommended value of the work function for each surface examined, along with an uncertainty estimate for that value. The uncertainties are based in part on the error distribution for all measured work functions in the literature, which is included here. The metals included in this review are silver (Ag), aluminum (Al), gold (Au), copper (Cu), iron (Fe), iridium (Ir), molybdenum (Mo), niobium (Nb), nickel (Ni), palladium (Pd), platinum (Pt), rhodium (Rh), ruthenium (Ru), tantalum (Ta), and tungsten (W)

  12. Influence of sex and age on the biological half-life of cadmium in mice

    Energy Technology Data Exchange (ETDEWEB)

    Taguchi, T. (Kochi Medical School, Nangoku-shi, Japan); Suzuki, S.

    1981-02-01

    The influence of age on the whole-body biological half-life of /sup 109/Cd was studied in male mice following ip injection. The influence of sex on whole-body and organ retention was ascertained after sc injection. The whole-body biological half-life of /sup 109/Cd of the older mice was more than twice that of the younger mice, and that of the female mice was longer than that of the males. These differences demonstrate a biological difference between males and females with respect to whole-body half-life of /sup 109/Cd. The effects of age and sex on the biological half-life of Cd in mice are assessed quantitatively.

  13. Dependence of the half-life of 221Fr on the implantation environment

    DEFF Research Database (Denmark)

    Olaizola, B.; Fraile, L.M.; Riisager, Karsten

    2010-01-01

    The possible dependence of the half-life of 221Fr on the solid-state environment has been investigated by the simultaneous measurement of implanted 221Fr ions in an insulator (Si) and a metallic substrate (Au) at the ISOLDE facility at CERN. Our results indicate that, if existing, the difference...... in half-life does not follow a systematic trend and it is well below 1%...

  14. Label-free Fab and Fc affinity/avidity profiling of the antibody complex half-life for polyclonal and monoclonal efficacy screening.

    Science.gov (United States)

    Read, Thomas; Olkhov, Rouslan V; Williamson, E Diane; Shaw, Andrew M

    2015-09-01

    A unified approach to affinity screening for Fab and Fc interactions of an antibody for its antigen and FcγR receptor has been developed. An antigen array is used for the Fab affinity and cross-reactivity screening and protein A/G proxy is the FcγR receptor. The affinities are derived using a simple 1:1 binding model with a consistent error analysis. The association and dissociation kinetics are measured over optimised times for accurate determination. The Fab/Fc affinities are derived for ten antibodies: mAb-actin (mouse), pAb-BSA (sheep), pAb-collagen V (rabbit), pAb-CRP (goat), mAb-F1 (mouse), mAbs (mouse) 7.3, 12.3, 29.3, 36.3 and 46.3 raised against LcrV in Yersinia pestis. The rate of the dissociation of antigen-antibody complexes relates directly to their immunological function as does the Fc-FcγR complex and a new half-life plot has been defined with a Fab/Fc half-life range of 17-470 min. The upper half-life value points to surface avidity. Two antibodies that are protective as an immunotherapy define a Fab half-life >250 min and an Fc half-life >50 min as characteristics of ideal interactions which can form the basis of an antibody screen for immunotherapy.

  15. Variation in absorption and half-life of hydrocortisone influence plasma cortisol concentrations.

    Science.gov (United States)

    Hindmarsh, Peter C; Charmandari, Evangelia

    2015-04-01

    Hydrocortisone therapy should be individualized in congenital adrenal hyperplasia (CAH) patients to avoid over and under replacement. We have assessed how differences in absorption and half-life of cortisol influence glucocorticoid exposure. Forty-eight patients (21 M) aged between 6·1 and 20·3 years with CAH due to CYP21A2 deficiency were studied. Each patient underwent a 24-h plasma cortisol profile with the morning dose used to calculate absorption parameters along with an intravenous (IV) hydrocortisone (15 mg/m(2) body surface area) bolus assessment of half-life. Parameters derived were maximum plasma concentration (Cmax ), time of maximum plasma concentration (tmax ), time to attaining plasma cortisol concentration cortisol. Mean half-life was 76·5 ± 5·2 (range 40-225·3) min, Cmax 780·7 ± 61·6 nmol/l and tmax 66·7 (range 20-118) min. Time taken to a plasma cortisol concentration less than 100 nmol/l was 289 (range 140-540) min. Those with a fast half-life and slow tmax took longest to reach a plasma cortisol concentration less than 100 nmol/l (380 ± 34·6 min), compared to those with a slow half-life and fast tmax (298 ± 34·8 min) and those with a fast half-life and fast tmax (249·5 ± 14·4 min) (One-way anovaF = 4·52; P = 0·009). Both rate of absorption and half-life of cortisol in the circulation play important roles in determining overall exposure to oral glucocorticoid. Dose regimens need to incorporate estimates of these parameters into determining the optimum dosing schedule for individuals. © 2014 John Wiley & Sons Ltd.

  16. Movement Complexity and Neuromechanical Factors Affect the Entropic Half-Life of Myoelectric Signals

    Directory of Open Access Journals (Sweden)

    Emma F. Hodson-Tole

    2017-09-01

    Full Text Available Appropriate neuromuscular functioning is essential for survival and features underpinning motor control are present in myoelectric signals recorded from skeletal muscles. One approach to quantify control processes related to function is to assess signal variability using measures such as Sample Entropy. Here we developed a theoretical framework to simulate the effect of variability in burst duration, activation duty cycle, and intensity on the Entropic Half-Life (EnHL in myoelectric signals. EnHLs were predicted to be <40 ms, and to vary with fluctuations in myoelectric signal amplitude and activation duty cycle. Comparison with myoelectic data from rats walking and running at a range of speeds and inclines confirmed the range of EnHLs, however, the direction of EnHL change in response to altered locomotor demand was not correctly predicted. The discrepancy reflected different associations between the ratio of the standard deviation and mean signal intensity (Ist:It¯ and duty factor in simulated and physiological data, likely reflecting additional information in the signals from the physiological data (e.g., quiescent phase content; variation in action potential shapes. EnHL could have significant value as a novel marker of neuromuscular responses to alterations in perceived locomotor task complexity and intensity.

  17. Designing of peptides with desired half-life in intestine-like environment

    KAUST Repository

    Sharma, Arun

    2014-08-20

    Background: In past, a number of peptides have been reported to possess highly diverse properties ranging from cell penetrating, tumor homing, anticancer, anti-hypertensive, antiviral to antimicrobials. Owing to their excellent specificity, low-toxicity, rich chemical diversity and availability from natural sources, FDA has successfully approved a number of peptide-based drugs and several are in various stages of drug development. Though peptides are proven good drug candidates, their usage is still hindered mainly because of their high susceptibility towards proteases degradation. We have developed an in silico method to predict the half-life of peptides in intestine-like environment and to design better peptides having optimized physicochemical properties and half-life.Results: In this study, we have used 10mer (HL10) and 16mer (HL16) peptides dataset to develop prediction models for peptide half-life in intestine-like environment. First, SVM based models were developed on HL10 dataset which achieved maximum correlation R/R2 of 0.57/0.32, 0.68/0.46, and 0.69/0.47 using amino acid, dipeptide and tripeptide composition, respectively. Secondly, models developed on HL16 dataset showed maximum R/R2 of 0.91/0.82, 0.90/0.39, and 0.90/0.31 using amino acid, dipeptide and tripeptide composition, respectively. Furthermore, models that were developed on selected features, achieved a correlation (R) of 0.70 and 0.98 on HL10 and HL16 dataset, respectively. Preliminary analysis suggests the role of charged residue and amino acid size in peptide half-life/stability. Based on above models, we have developed a web server named HLP (Half Life Prediction), for predicting and designing peptides with desired half-life. The web server provides three facilities; i) half-life prediction, ii) physicochemical properties calculation and iii) designing mutant peptides.Conclusion: In summary, this study describes a web server \\'HLP\\' that has been developed for assisting scientific

  18. Half-life of Re184 populated by the (γ,n) reaction from laser Compton scattering γ rays at the electron storage ring NewSUBARU

    Science.gov (United States)

    Hayakawa, T.; Miyamoto, S.; Hayashi, Y.; Kawase, K.; Horikawa, K.; Chiba, S.; Nakanishi, K.; Hashimoto, H.; Ohta, T.; Kando, M.; Mochizuki, T.; Kajino, T.; Fujiwara, M.

    2006-12-01

    We report a half-life of the ground state of Re184 populated by the Re185(γ,n)Re184 reaction from laser Compton scattering γ rays generated through relativistic engineering. The γ rays are provided at the electron storage ring NewSUBARU. The previous experiment using deuteron-induced reactions has yielded a recommended half-life of the 3- ground state of Re184 of 38.0±0.5 d, including a possible contribution from the 8+ isomer (T1/2=169±8 d) of Re184 since the presence of the isomer was not known at that time. In contrast, the (γ,n) reaction has an advantage to selectively populate the ground state because this reaction does not bring large angular momentum. The measured half-life of 35.4±0.7 d is shorter than the previous half-life by about 7%. This difference is crucial for applications using the activation method.

  19. β-decay half-life of V50 calculated by the shell model

    Science.gov (United States)

    Haaranen, M.; Srivastava, P. C.; Suhonen, J.; Zuber, K.

    2014-10-01

    In this work we survey the detectability of the β- channel of 2350V leading to the first excited 2+ state in 2450Cr. The electron-capture (EC) half-life corresponding to the transition of 2350V to the first excited 2+ state in 2250Ti had been measured earlier. Both of the mentioned transitions are 4th-forbidden non-unique. We have performed calculations of all the involved wave functions by using the nuclear shell model with the GXPF1A interaction in the full f-p shell. The computed half-life of the EC branch is in good agreement with the measured one. The predicted half-life for the β- branch is in the range ≈2×1019 yr whereas the present experimental lower limit is 1.5×1018 yr. We discuss also the experimental lay-out needed to detect the β--branch decay.

  20. Shorter 146Sm half-life and revised 146Sm-142Nd ages of planetary mantle differentiation

    CERN Document Server

    Kinoshita, N; Kashiv, Y; Collon, P; Deibel, C M; DiGiovine, B; Greene, J P; Henderson, D J; Jiang, C L; Marley, S T; Nakanishi, T; Pardo, R C; Rehm, K E; Robertson, D; Scott, R; Schmitt, C; Tang, X D; Vondrasek, R; Yokoyama, A

    2011-01-01

    The extinct short-lived nuclide 146Sm, synthesized in stellar events by the p-process, serves as both an astrophysical and geochemical chronometer through measurements of isotopic anomalies of its alpha-decay daughter 142Nd. Evidence of live 146Sm, quantitatively established for the early Solar System, constrains the time between p-process nucleosynthesis and condensation of the first solid materials. Samarium-146 is used also to date silicate mantle differentiation events in a number of planetary bodies, including Earth. We performed a new measurement of the 146Sm half-life and our result, t = 68\\pm7 (1sigma) million year (Ma), is significantly shorter than the value currently used for 146Sm-142Nd chronology (103\\pm5 Ma). We show here that the shorter 146Sm half-life value implies a higher initial Solar System ratio, (146Sm/144Sm)_0 = 0.0094\\pm0.0005 (2sigma), than the recently derived value 0.0085\\pm0.0007, or that used in most studies 0.008\\pm0.001. Planetary differentiation processes dated by 146Sm-142Nd ...

  1. Determination of the 10Be half-life by multicollector ICP-MS and liquid scintillation counting

    Science.gov (United States)

    Chmeleff, Jérôme; von Blanckenburg, Friedhelm; Kossert, Karsten; Jakob, Dieter

    2010-01-01

    A new method was designed and used for determining the half-life of the isotope 10Be. The method is based on (1) accurate 10Be/ 9Be measurements of 9Be-spiked solutions of a 10Be-rich master solution using multicollector ICP mass spectrometry (MC-ICP-MS) and (2) liquid scintillation counting (LSC) using the CIEMAT/NIST method for determining the activity concentrations of the solutions whose 10Be concentrations were determined by mass spectrometry. Important requirements for the success of this approach (a) was the previous coating of glass ampoules filled for counting experiments with 9Be, thereby reducing the risk of the adsorptive loss of 10Be; (b) the removal of Boron from solutions to be measured by MC-ICP-MS by cation chromatography without the introduction of mass fractionation and (c) the accurate determination of the mass bias of 10Be/ 9Be measurements by ICP-MS which are always affected by the space-charge effect. The mass bias factor was determined to be 1.1862 ± 0.071 for 10Be/ 9Be from careful fitting and error propagation of ratios of measured Li, B, Si, Cr, Fe, Cu, Sr, Nd, Hf, Tl and U standard solutions of known composition under the same measurement conditions. Employing this factor, an absolute 10Be/ 9Be ratio of 1.464 ± 0.014 was determined for a first dilution of the 10Be-rich master solution. This solution is now available as an absolute Be ratio standard in AMS measurements. Finally, a half-life of (1.386 ± 0.016) My (standard uncertainty) was calculated. This value is much more precise than previous estimates and was derived from a fully independent set of experiments. In a parallel, fully independent study using the same master solution, Korschinek et al. [35] have determined a half-life of (1.388 ± 0.018) My. The combined half-life and uncertainty amounts to (1.387 ± 0.012) My. We suggest the use of this value in nuclear studies and in studies that make use of cosmogenic 10Be in environmental and geologic samples.

  2. Safety and Efficacy of BAY 94-9027, a Prolonged-Half-Life Factor VIII

    DEFF Research Database (Denmark)

    Reding, M T; Ng, H J; Poulsen, Lone Hvitfeldt

    2016-01-01

    BACKGROUND: BAY 94-9027 is a B-domain-deleted prolonged-half-life recombinant factor VIII (FVIII) conjugates in a site-specific manner with polyethylene glycol. OBJECTIVE: Assess efficacy and safety of BAY 94-9027 for prophylaxis and treatment of bleeds in patients with severe hemophilia A PATIEN...

  3. Study on Radiochemical Separation and Measurement of Half-life of ~(88)Kr

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    88Kr is one of the important gaseous fission products for determining the burn up of nuclear fuel with a short half-life, high fission yield and high branch ratio of γ-ray. Due to the more uncertainty of evaluated data and rare experimented data,

  4. 89Rb半衰期测量%Half-life Measurement of 89 Rb

    Institute of Scientific and Technical Information of China (English)

    郭晓清; 袁大庆; 徐利军; 陈克胜; 吴永乐; 郑艳明; 姚顺和

    2013-01-01

    89 Rb is an important fission product used for monitoring possible release of fission products from fuel element .The half-life is one of important nuclear parameters . The half-life of 89 Rb was determined using reference source method with two sets of HPGe detectors by place-relay way .In reference source method ,the ratio of net full-energy peak areas from the measure nuclide and the reference source was used to avoid the count correction caused by dead time and pileup .For the very short half-life of 89 Rb , the half-life iterative method was used in data analysis and the translation method was used in data unification .Finally ,the measured half-life of 89 Rb is (14.41 ± 0.04) min .%89 Rb是重要的裂变产物核素,半衰期是其一项非常重要的核参数。本文采用参考源法,运用双HPGe探头距离接续测定了89 Rb的半衰期。参考源法利用待测源和参考源的γ射线全能峰之比消除了测量过程中死时间和脉冲堆积带来的计数修正影响。由于89 Rb半衰期较短,数据分析运用了半衰期迭代法,并用平移法归一探头测量数据,最终实验测得89 Rb半衰期为(14.41±0.04) min。

  5. A half-life the divided life of Bruno Pontecorvo, physicist or spy

    CERN Document Server

    Close, Frank

    2015-01-01

    Bruno Pontecorvo dedicated his career to hunting for the Higgs boson of his day: the neutrino, a nearly massless particle considered essential to the process of nuclear fission. His work on the Manhattan project under Enrico Fermi confirmed his reputation as a brilliant physicist and helped usher in the nuclear age. He should have won a Nobel Prize, but late in the summer of 1950 he vanished. At the height of the Cold War, Pontecorvo had disappeared behind the Iron Curtain. In Half-Life, physicist and historian Frank Close offers a heretofore untold history of Pontecorvo’s life, based on unprecedented access to his friends, family, and colleagues. With all the elements of a Cold War thriller—classified atomic research, an infamous double agent, a kidnapping by Soviet operatives—Half-Life is a history of particle physics at perhaps its most powerful: when it created the bomb.

  6. Half-life extended factor VIII for the treatment of hemophilia A.

    Science.gov (United States)

    Tiede, A

    2015-06-01

    Prophylactic infusion of factor VIII (FVIII) prevents joint bleeding and other hemorrhages in patients with hemophilia A. Conventional FVIII concentrates have a short half-life, with an average of about 12 h in adults, ranging in individual patients between 6 and 24 h, and even shorter in younger children. Therefore, effective prophylaxis requires frequent intravenous injection, usually three times per week or every other day. Several technologies are currently under investigation to extend the half-life of FVIII, including Fc fusion (Eloctate, Elocta, efmoroctocog alfa), addition of polyethylene glycol (turoctocog alfa pegol [N8-GP], BAY 94-9027, BAX 855), and a single-chain construct (CSL627). This review summarizes characteristics of products in clinical development and discusses their potential benefits.

  7. Unified description of the proton, alpha, cluster decays and spontaneously fissions half- life

    CERN Document Server

    Mavrodiev, Strachimir Cht

    2016-01-01

    Some time ago the possibility of classical (without Gamow tunneling) universal description of radioactive nuclei decay was demonstrated. Such possibility is basis on the classical interpretation of Bohmian Psi-field reality in Bohmian-Chetaev mechanics and the hypothesis for the presence of dissipative forces, generated from the Gryzinski translational precession of the charged particles spin, in Langevin- Kramers diffusion mechanism. In this paper is present an unified model of proton, alpha decay, cluster radioactivity and spontaneous fission half-life as explicit function which depends on the total decay energy and kinetic energy, the number of protons and neutrons of daughter product, the number of protons and neutrons of mother nuclei and from a set) unknown digital parameters. The Half- lifes of the 573 nuclei taken from NuDat database together with the recent experimental data from Oganessian provide a basis for discovering the explicit form of the Kramers solution of Langevin type equation in a framew...

  8. Theoretical half-life for beta decay of {sup 96}Zr

    Energy Technology Data Exchange (ETDEWEB)

    Heiskanen, H; Mustonen, M T; Suhonen, J [Department of Physics, University of Jyvaeskylae, PO Box 35, FIN-40351, Jyvaeskylae (Finland)

    2007-05-15

    Highly forbidden {beta}{sup -} decay of the 0{sup +} ground state of {sup 96}Zr is studied. Partial half-lives to the lowest 6{sup +}, 5{sup +} and 4{sup +} states of {sup 96}Nb have been computed using the proton-neutron quasiparticle random-phase approximation (pnQRPA) with realistic two-body interactions in a large single-particle space. We find that the decay is dominated by the unique fourth-forbidden transition to the 5{sup +} state with the half-life 2.4 x 10{sup 20} y. This half-life is an order of magnitude longer than the one measured for the double beta decay of {sup 96}Zr.

  9. Discussions about whether radioactive half life can be changed by mechanic motion

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In this essay, some discussions and comments about the paper entitled "Can the decay rate of 32P be changed by mechanic motion?" (Ding et al., Science in China Series B:Chemistry (Chinese version), 2008, 38(11):1035-1037) are given. It was strongly suggested that its experimental methods, data calculations and conclusion should be reconsidered. After the data were recalculated, the new results supported that the chiral mechanic motion could induce the changes of radioactive half life.

  10. The half-life and exposure of cefuroxime varied in newborn infants after a Caesarean section

    DEFF Research Database (Denmark)

    Zachariassen, G.; Hyldig, N.; Joergensen, J.S.

    2016-01-01

    in normal adults and seemed to clear within 24 hours. The median area under the concentration–time curve was 65.0 hour μg/mL (range 31.7–162.4). Conclusion: We found that the cefuroxime half-life after a Caesarean section varied among infants and was longer than in normal adults but cleared within 24 hours....... Exposure to cefuroxime in newborn infants may influence the gut microbiota and should be investigated further....

  11. The half-life of the 1437 keV 11/2 sup - state in sup 97 Mo

    Energy Technology Data Exchange (ETDEWEB)

    Kostova, L.G.; Andrejtscheff, W.; Kostov, L.K. (Bylgarska Akademiya na Naukite, Sofia (Bulgaria). Inst. za Yadrena Izsledvaniya i Yadrena Energetika); Funke, L.; Will, E. (Zentralinstitut fuer Kernforschung, Rossendorf (Germany)); Vdovin, A.I. (Joint Inst. for Nuclear Research, Dubna (Russia))

    1992-05-01

    Using the ({alpha}, n) reaction, the half-life of the first 11/2{sup -} level in {sup 97}Mo has been determined as T{sub 1/2}(1437.0 keV)=2.5{+-}0.3 ns by means of the pulsed beam method. The experimentally obtained B(M2) value between the h{sub 11/2} and g{sub 7/2} configurations in {sup 97}Mo has been satisfactorily described within the quasiparticle-phonon model using g{sub s}{sup eff}=0.6 g{sub s}{sup free} c{sub s}. Similar calculations and comparisons with experimental data have been performed also for {sup 95,99}Mo as well as for {sup 99}Ru and {sup 101}Pd. (orig.).

  12. The functional half-life of an mRNA depends on the ribosome spacing in an early coding region

    DEFF Research Database (Denmark)

    Pedersen, Margit; Nissen, Søren; Mitarai, Namiko;

    2011-01-01

    . Here, we characterize a determinant of the functional stability of an mRNA, which is located in the early coding region. Using literature values for the mRNA half-lives of variant lacZ mRNAs in Escherichia coli, we modeled how the ribosome spacing is affected by the translation rate of the individual...... of slowly translated codons before codon 20 or after codon 45 should shorten or prolong, respectively, the functional mRNA half-life by altering the ribosome density in the important region. These predictions were tested on eight new lacZ variants, and their experimentally determined mRNA half-lives all...

  13. Measurement of the Two-Neutrino Double Beta Decay Half-life of $^{130}$Te with the CUORE-0 Experiment

    CERN Document Server

    Alduino, C; Artusa, D R; Avignone, F T; Azzolini, O; Banks, T I; Bari, G; Beeman, J W; Bellini, F; Bersani, A; Biassoni, M; Branca, A; Brofferio, C; Bucci, C; Camacho, A; Caminata, A; Canonica, L; Cao, X G; Capelli, S; Cappelli, L; Carbone, L; Cardani, L; Carniti, P; Casali, N; Cassina, L; Chiesa, D; Chott, N; Clemenza, M; Copello, S; Cosmelli, C; Cremonesi, O; Creswick, R J; Cushman, J S; D'Addabbo, A; Dafinei, I; Davis, C J; Dell'Oro, S; Deninno, M M; Di Domizio, S; Di Vacri, M L; Drobizhev, A; Fang, D Q; Faverzani, M; Fernandes, G; Ferri, E; Ferroni, F; Fiorini, E; Franceschi, M A; Freedman, S J; Fujikawa, B K; Giachero, A; Gironi, L; Giuliani, A; Gladstone, L; Gorla, P; Gotti, C; Gutierrez, T D; Haller, E E; Han, K; Hansen, E; Heeger, K M; Hennings-Yeomans, R; Hickerson, K P; Huang, H Z; Kadel, R; Keppel, G; Kolomensky, Yu G; Leder, A; Ligi, C; Lim, K E; Liu, X; Ma, Y G; Maino, M; Marini, L; Martinez, M; Maruyama, R H; Mei, Y; Moggi, N; Morganti, S; Mosteiro, P J; Napolitano, T; Nones, C; Norman, E B; Nucciotti, A; O'Donnell, T; Orio, F; Ouellet, J L; Pagliarone, C E; Pallavicini, M; Palmieri, V; Pattavina, L; Pavan, M; Pessina, G; Pettinacci, V; Piperno, G; Pira, C; Pirro, S; Pozzi, S; Previtali, E; Rosenfeld, C; Rusconi, C; Sangiorgio, S; Santone, D; Scielzo, N D; Singh, V; Sisti, M; Smith, A R; Taffarello, L; Tenconi, M; Terranova, F; Tomei, C; Trentalange, S; Vignati, M; Wagaarachchi, S L; Wang, B S; Wang, H W; Wilson, J; Winslow, L A; Wise, T; Woodcraft, A; Zanotti, L; Zhang, G Q; Zhu, B X; Zimmermann, S; Zucchelli, S

    2016-01-01

    We report on the measurement of the two-neutrino double beta decay half-life of $^{130}$Te with the CUORE-0 detector. From an exposure of 33.4 kg$\\cdot$y of TeO$_2$, the half-life is determined to be $T_{1/2}^{2\

  14. Direct Deposition Effect on the Distribution of Radiocesium in Persimmon Trees and the Effective Half-life

    Energy Technology Data Exchange (ETDEWEB)

    Tagami, Keiko; Uchida, Shigeo [National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba 263-7444 (Japan)

    2014-07-01

    Radiocesium ({sup 137}Cs) concentrations in persimmon tree tissues collected at Chiba, about 220 km south from Fukushima Daiichi nuclear power plant (FDNPP), were measured to obtain half-life of radiocesium in the trees. Persimmon (Diospyros kaki) is a deciduous tree and bears edible fruits in autumn. There were no leaves when the sampling area was received the radioactive fallout in March 2011 due to the FDNPP accident; the amount of {sup 137}Cs radioactivity in this area was ca. 13 kBq/m{sup 3} Both {sup 137}Cs and {sup 134}Cs were found in the newly emerged shoots of the persimmon trees collected at 26 April 2011 mainly due to foliar uptake. The concentrations were 1.1 kBq/kg-dry for {sup 137}Cs and 1.3 kBq/kg-dry for {sup 134}Cs. After that, continuous sampling of leaves, branches and fruits of the persimmon trees had been carried out for two years. Immediately after the collection, samples were transferred to our laboratory and weighed to obtain fresh weight. Leaf samples were usually separated into two portions; one portion was washed with tap water to remove dust from the surface and the other portion was not treated. For fruit samples, if it is possible, fruit flesh, peal and non-edible part were separated. All the samples were oven-dried at 80 deg. C for three days at least. Each dried sample was chopped into fine pieces, mixed well, and then transferred into plastic vessels separately. Radioactivity concentration was measured by a Ge-detecting system (Seiko EG and G Ortec) using 3000-40000 s counting intervals. By August 14, 2013, about 140 samples were collected from the trees; about 60 samples were leaves (both washed and untreated). Radiocesium concentrations in tree leaves decreased with time, and the effective half-life was about 190 d; the value was similar to those in branches (160 d for new branches, and 250 d for 1-2 y.o. branches) and fruits (250 d for fruit flesh and 230 d for peals). Thus we concluded that the half-life of radiocesium in

  15. A novel method to determine the half-life of 32Si

    Science.gov (United States)

    Schnabel, C.; Beer, J.; Clausen, H. B.

    2009-04-01

    A novel method using high-resolution 10Be concentrations to correct 32Si data from independently dated depth profiles is presented. It is demonstrated that by correcting 32Si deposition rates for temporal changes based on production rate fluctuations the derived half-life of 32Si agrees with half-life determinations based on physical measurements of artificial samples. Currently, the half-life of 32Si is not accurately known. Moreover, results from physical measurements of artificial samples yielded much shorter half-lives (100-172 yr) than results based on depth profiles. For depth profiles most results were between 250 and 300 yr (Clausen, 1973), with the exception of a relatively recent work on a varved lake sediment which resulted in 178 yr (Nijampurkar et al., 1998). Using high-resolution 10Be concentrations from the Dye3 ice-core each data point of the Northern hemisphere ice-core 32Si concentrations is corrected for temporal variations in deposition rate. This means that we assume that temporal variations in 32Si and 10Be deposition are identical instead of using the assumption of constant deposition rates that resulted in the long half-lives. In the case of the varved lake sediment, 32Si/Si ratios are corrected in the same way as 32Si concentrations for the ice cores. We present our results that half-lives of longer than 180 yr can be ruled out for 32Si and propose using 10Be and 32Si concentrations from the same samples of independently dated profiles as a new method to apply 32Si for dating purposes. Preliminary results have been presented at the QRA meeting in Glasgow 2006 {schnabel et al., 2006]. HB Clausen, Journal of Glaciology 12 (1973) 411. VN Nijampurkar et al., Earth and Planetary Science Letters 163 (1998) 191. C. Schnabel, J. Beer, HB Clausen, QRA annual discussion meeting Glasgow, 2006.

  16. The Half Life of the 53 keV Level in {sup 197}Pt

    Energy Technology Data Exchange (ETDEWEB)

    Malmskog, S.G.

    1967-02-15

    The half life of the recently proposed 53 keV level in {sup 197}Pt has been measured to 18.5 {+-} 1.5 nsec using the delayed coincidence technique. This level, which is identified with the f{sub 5/2} single particle state, decays directly to the p{sub 1/2} ground state in {sup 197}Pt. The reduced E2 transition probability for this 53 keV transition has been deduced and compared with the results obtained for the corresponding transitions in other Pt, Hg, and Pb isotopes and with the theoretical predictions by Sorensen and by Wahlborn and Martinson.

  17. Calculation of the Aluminosilicate Half-Life Formation Time in the 2H Evaporator

    Energy Technology Data Exchange (ETDEWEB)

    Fondeur, F.F.

    2000-09-21

    The 2H Evaporator contains large quantities of aluminosilicate solids deposited on internal fixtures. The proposed cleaning operations will dissolve the solids in nitric acid. Operations will then neutralize the waste prior to transfer to a waste tank. Combining recent calculations of heat transfer for the 2H Evaporator cleaning operations and laboratory experiments for dissolution of solid samples from the pot, the authors estimated the re-formation rate for aluminosilicates during cooling. The results indicate a half-life formation of 17 hours when evaporator solution cools from 60 degrees C and 9 hours when cooled from 90 degrees C.

  18. The evolution of drug-resistant malaria: the role of drug elimination half-life.

    OpenAIRE

    Hastings, Ian M.; Watkins, William M; White, Nicholas J

    2002-01-01

    This paper seeks to define and quantify the influence of drug elimination half-life on the evolution of antimalarial drug resistance. There are assumed to be three general classes of susceptibility of the malaria parasite Plasmodium falciparum to a drug: Res0, the original, susceptible wildtype; Res1, a group of intermediate levels of susceptibility that are more tolerant of the drug but still cleared by treatment; and Res2, which is completely resistant to the drug. Res1 and Res2 resistance ...

  19. Study of the dependence of 198Au half-life on source geometry

    CERN Document Server

    Lindstrom, R M; Buncher, J B; Greene, G L; Jenkins, J H; Krause, D E; Mattes, J J; Yue, A; 10.1016/j.nima.2010.06.270

    2010-01-01

    We report the results of an experiment to determine whether the half-life of \\Au{198} depends on the shape of the source. This study was motivated by recent suggestions that nuclear decay rates may be affected by solar activity, perhaps arising from solar neutrinos. If this were the case then the $\\beta$-decay rates, or half-lives, of a thin foil sample and a spherical sample of gold of the same mass and activity could be different. We find for \\Au{198}, $(T_{1/2})_{\\rm foil}/(T_{1/2})_{\\rm sphere} = 0.999 \\pm 0.002$, where $T_{1/2}$ is the mean half-life. The maximum neutrino flux at the sample in our experiments was several times greater than the flux of solar neutrinos at the surface of the Earth. We show that this increase in flux leads to a significant improvement in the limits that can be inferred on a possible solar contribution to nuclear decays.

  20. Changing Paradigm of Hemophilia Management: Extended Half-Life Factor Concentrates and Gene Therapy.

    Science.gov (United States)

    Kumar, Riten; Dunn, Amy; Carcao, Manuel

    2016-02-01

    Management of hemophilia has evolved significantly in the last century-from recognition of the causative mechanism in the 1950s to commercially available clotting factor concentrates in the 1960s. Availability of lyophilized concentrates in the 1970s set the stage for home-based therapy, followed by introduction of virally attenuated plasma-derived, and then recombinant factor concentrates in the 1980s and 1990s, respectively. The subsequent years saw a paradigm shift in treatment goals from on-demand therapy to prophylactic factor replacement starting at an early age, to prevent hemarthrosis becoming the standard of care for patients with severe hemophilia. In the developed world, the increasing use of home-based prophylactic regimens has significantly improved the quality of life, and life expectancy of patients with severe hemophilia. Seminal developments in the past 5 years, including the commercial availability of extended half-life factor concentrates and the publication of successful results of gene therapy for patients with hemophilia B, promise to further revolutionize hemophilia care over the next few decades. In this review, we summarize the evolution of management for hemophilia, with a focus on extended half-life factor concentrates and gene therapy. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  1. HALO--a Java framework for precise transcript half-life determination.

    Science.gov (United States)

    Friedel, Caroline C; Kaufmann, Stefanie; Dölken, Lars; Zimmer, Ralf

    2010-05-01

    Recent improvements in experimental technologies now allow measurements of de novo transcription and/or RNA decay at whole transcriptome level and determination of precise transcript half-lives. Such transcript half-lives provide important insights into the regulation of biological processes and the relative contributions of RNA decay and de novo transcription to differential gene expression. In this article, we present HALO (Half-life Organizer), the first software for the precise determination of transcript half-lives from measurements of RNA de novo transcription or decay determined with microarrays or RNA-seq. In addition, methods for quality control, filtering and normalization are supplied. HALO provides a graphical user interface, command-line tools and a well-documented Java application programming interface (API). Thus, it can be used both by biologists to determine transcript half-lives fast and reliably with the provided user interfaces as well as software developers integrating transcript half-life analysis into other gene expression profiling pipelines. Source code, executables and documentation are available at http://www.bio.ifi.lmu.de/software/halo.

  2. High-Precision Half-life Measurements for the Superallowed β+ Emitter 14O

    Directory of Open Access Journals (Sweden)

    Laffoley A. T.

    2014-03-01

    Full Text Available The half-life of 14O, a superallowed Fermi β+ emitter, has been determined via simultaneous γ and β counting experiments at TRIUMF’s Isotope Separator and Accelerator facility. Following the implantation of 14O samples at the center of the 8π spectrometer, a γ counting measurement was performed by detecting the 2313 keV γ-rays emitted from the first excited state of the daughter 14N using 20 high-purity germanium (HPGe detectors. A simultaneous β counting experiment was performed using a fast plastic scintillator positioned directly behind the implantation site. The results, T½(γ = 70:632 ± 0:094 s and T½(β = 70:610 ± 0:030 s, are consistent with one another and, together with eight previous measurements, establish a new average for the 14O half-life of T½ = 70:619 ± 0:011 s with a reduced χ2 of 0.99.

  3. Protein HESylation for half-life extension: synthesis, characterization and pharmacokinetics of HESylated anakinra.

    Science.gov (United States)

    Liebner, Robert; Mathaes, Roman; Meyer, Martin; Hey, Thomas; Winter, Gerhard; Besheer, Ahmed

    2014-07-01

    Half-life extension (HLE) is becoming an essential component of the industrial development of small-sized therapeutic peptides and proteins. HESylation(®) is a HLE technology based on coupling drug molecules to the biodegradable hydroxyethyl starch (HES). In this study, we report on the synthesis, characterization and pharmacokinetics of HESylated anakinra, where anakinra was conjugated to propionaldehyde-HES using reductive amination, leading to a monoHESylated protein. Characterization using size exclusion chromatography and dynamic light scattering confirmed conjugation and the increase in molecular size, while Fourier transform infrared spectroscopy showed that the secondary structure of the conjugate was not affected by coupling. Meanwhile, microcalorimetry and aggregation studies showed a significant increase in protein stability. Surface plasmon resonance and microscale thermophoresis showed that the conjugate retained its nanomolar affinity, and finally, the pharmacokinetics of the HESylated protein exhibited a 6.5-fold increase in the half-life, and a 45-fold increase in the AUC. These results indicate that HESylation(®) is a promising HLE technology.

  4. Isolation of human anti-serum albumin Fab antibodies with an extended serum-half life.

    Science.gov (United States)

    Kang, Hyeon-Ju; Kim, Hye-Jin; Cha, Sang-Hoon

    2016-01-01

    The serum albumin (SA) has been exploited to generate long-acting biotherapeutics by taking advantage of the FcRn-mediated recycling mechanism in a direct or an indirect way. Since Fab fragments have been proven to be clinically safe for human usage, we assumed that human anti-SA Fab antibodies could have a great potential as a carrier molecule to extend the serum half-life of therapeutic proteins. We, herein, had attempted to isolate anti-SA Fab antibodies from HuDVFab-8L antibody library via a phage display technology, and identified eight discrete human Fab antibodies. One of the Fab antibodies, SL335, showed the strongest binding reactivity to human SA with nM range of affinity at both pH 6 and pH 7.4, and cross-reacted to SAs from various species including rat, mouse, canine and monkey. The in vivo pharmacokinetic assay using a rat model indicated that SL335 has approximately 10 fold longer serum half-life and 26 to 44-fold increase in AUC0 → ∞ compared to the negative control Fab molecule in both intravenous and subcutaneous administrations. Knowing that Fabs have proven to be safe in clinics for a long time, SL335 seems to have a great potential in generating long-acting protein drugs by tagging effector molecules with either chemical conjugation or genetic fusion.

  5. Recommended Partition Coefficient (Kd) Values for Nuclide Partitioning in the Presence of Cellulose Degradation Products

    Energy Technology Data Exchange (ETDEWEB)

    Serkiz, S.M.

    2001-02-23

    This report documents the data analysis of the results of the described laboratory studies in order to recommend Kd values for use in Performance Assessment modeling of nuclide transport in the presence of CDP.

  6. Recommendations

    Science.gov (United States)

    Brazelton, G. Blue; Renn, Kristen A.; Stewart, Dafina-Lazarus

    2015-01-01

    In this chapter, the editors provide a summary of the information shared in this sourcebook about the success of students who have minoritized identities of sexuality or gender and offer recommendations for policy, practice, and further research.

  7. Precision measurement of the half-life of $^{109}$In in large and small lattice environments

    CERN Multimedia

    We propose to undertake high precision measurements of the half-life of $^{109}$In in large and small lattice environments to study the effect of compression on the electron capture nuclear decay rate. Such studies are of general interest having implications in many areas ranging from astrophysics to geophysics. At present, very little data is available on the change of electron capture decay rate under compression and the available data seems to indicate that the observed increase of the electron capture decay rate under compression is much greater than the predictions of the best available density functional calculations as obtained from TB-LMTO or WIEN2K codes. The proposed experiment should generate more data thus clarifying the experimental situation.

  8. Development of a time-variable nuclear pulser for half life measurements

    Energy Technology Data Exchange (ETDEWEB)

    Zahn, Guilherme S.; Domienikan, Claudio; Carvalhaes, Roberto P. M.; Genezini, Frederico A. [Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP. P.O. Box 11049, Sao Paulo, 05422-970 (Brazil)

    2013-05-06

    In this work a time-variable pulser system with an exponentially-decaying pulse frequency is presented, which was developed using the low-cost, open-source Arduino microcontroler plataform. In this system, the microcontroller produces a TTL signal in the selected rate and a pulse shaper board adjusts it to be entered in an amplifier as a conventional pulser signal; both the decay constant and the initial pulse rate can be adjusted using a user-friendly control software, and the pulse amplitude can be adjusted using a potentiometer in the pulse shaper board. The pulser was tested using several combinations of initial pulse rate and decay constant, and the results show that the system is stable and reliable, and is suitable to be used in half-life measurements.

  9. Half-life of each dioxin and PCB congener in the human body

    Energy Technology Data Exchange (ETDEWEB)

    Ogura, Isamura [National Institute of Advanced Industrial Science and Technology, Tsukuba (Japan)

    2004-09-15

    It is well known that dioxin and PCB congeners accumulate in the human body. For assessing their toxicological risk, it is important to know the half-life of each congener in the human body. This study summarizes the overall half-lives of congeners in humans as reported in the literature, and compares them with the half-lives due to fecal and sebum excretions, as estimated by data on the concentrations of congeners in feces and sebum in the literature. In addition, the overall half-lives of congeners for the general Japanese population were estimated from the data on dietary intakes and concentrations in the human body reported by the municipalities.

  10. Liposomal Formulation of Bevasizuamb for Intravitreal Administration: Increased Half-Life, Decreased Side Effects

    Directory of Open Access Journals (Sweden)

    Siamak Zarei Ghanavati

    2008-05-01

    Full Text Available Intravitreal injection is the common method for treatment of the posterior segment eye diseases. The advantage of intravitreal injection is achieving the desired concentration of drug inside the eye and reduction of drug side effects. Unfortunately, repeated intravitreal injections can cause several ocular complications including; vitreous hemorrhage, endophthalmitis, retinal detachment and cataract. For this reason, it seems the usage of sustained release drug delivery systems is helpful. Bevacizumab (Avastin®, antivascular endothelial growth factor (VEGF monoclonal antibody, is used for the treatment of different ocular diseases such as neovascular age-related macular degeneration, neovascular glaucoma, diabetic retinopathy, retinal vein occlusions, etc. For reduction of drug side effects and improvement of drug half-life after intravitreal administration, we suggest preparation of liposomal bevacizumab as novel drug delivery system and comparison of this new formulation with conventional formulation in the market.

  11. Half-life measurement of neutron-rich isotope 237Th

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    60 MeV/u 18O ions were used to bombard natural uranium targets, and the heavy neutron-rich isotope 237Th was produced via multi-nucleon transfer reaction and dissipative fragmentation of the heavy target. A relatively fast radiochcmical procedure was used to separate thorium from the mixture of uranium and complex reaction products. The chemically separated thorium fractions were studied by the γ-ray spectroscopic method. The behaviors of the growth and decay of 853.7 and 865.0 keV γ rays of 237pa decay were observed. Thc half-life of 237Th was determined to be 4.69±0.60 min.

  12. The antitumor agent 3-bromopyruvate has a short half-life at physiological conditions.

    Science.gov (United States)

    Glick, Matthew; Biddle, Perry; Jantzi, Josh; Weaver, Samantha; Schirch, Doug

    2014-09-12

    Clinical research is currently exploring the validity of the anti-tumor candidate 3-bromopyruvate (3-BP) as a novel treatment for several types of cancer. However, recent publications have overlooked rarely-cited earlier work about the instability of 3-BP and its decay to 3-hydroxypyruvate (3-HP) which have obvious implications for its mechanism of action against tumors, how it is administered, and for precautions when preparing solutions of 3-BP. This study found the first-order decay rate of 3-BP at physiological temperature and pH has a half-life of only 77 min. Lower buffer pH decreases the decay rate, while choice of buffer and concentration do not affect it. A method for preparing more stable solutions is also reported.

  13. ORIGEN-S Decay Data Library and Half-Life Uncertainties

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, O.W.

    1998-01-01

    The results of an extensive update of the decay data of the ORIGEN-S library are presented in this report. The updated decay data were provided for both the ORIGEN-S and ORIGEN2 libraries in the same project. A complete edit of the decay data plus the available half-life uncertainties are included in Appendix A. A detailed description of the types of data contained in the library, the format of the library, and the data sources are also presented. Approximately 24% of the library nuclides are stable, 66% were updated from ENDF/B-VI, about 8% were updated from ENSDF, and the remaining 2% were not updated. Appendix B presents a listing of percentage changes in decay heat from the old to the updated library for all nuclides containing a difference exceeding 1% in any parameter.

  14. Degradation and half-life of DNA present in biomass from a genetically-modified organism during land application.

    Science.gov (United States)

    Halter, Mathew C; Zahn, James A

    2017-02-01

    White biotechnology has made a positive impact on the chemical industry by providing safer, more efficient chemical manufacturing processes that have reduced the use of toxic chemicals, harsh reaction conditions, and expensive metal catalysts, which has improved alignment with the principles of Green Chemistry. The genetically-modified (GM) biocatalysts that are utilized in these processes are typically separated from high-value products and then recycled, or eliminated. Elimination routes include disposal in sanitary landfills, incineration, use as a fuel, animal feed, or reuse as an agricultural soil amendment or other value-added products. Elimination routes that have the potential to impact the food chain or environment have been more heavily scrutinized for the fate and persistence of biological products. In this study, we developed and optimized a method for monitoring the degradation of strain-specific DNA markers from a genetically-modified organism (GMO) used for the commercial production of 1,3-propanediol. Laboratory and field tests showed that a marker for heterologous DNA in the GM organism was no longer detectable by end-point polymerase chain reaction (PCR) after 14 days. The half-life of heterologous DNA was increased by 17% (from 42.4 to 49.7 h) after sterilization of the soil from a field plot, which indicated that abiotic factors were important in degradation of DNA under field conditions. There was no evidence for horizontal transfer of DNA target sequences from the GMO to viable organisms present in the soil.

  15. PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy.

    Science.gov (United States)

    Morath, Volker; Bolze, Florian; Schlapschy, Martin; Schneider, Sarah; Sedlmayer, Ferdinand; Seyfarth, Katrin; Klingenspor, Martin; Skerra, Arne

    2015-05-04

    Leptin plays a central role in the control of energy homeostasis and appetite and, thus, has attracted attention for therapeutic approaches in spite of its limited pharmacological activity owing to the very short circulation in the body. To improve drug delivery and prolong plasma half-life, we have fused murine leptin with Pro/Ala/Ser (PAS) polypeptides of up to 600 residues, which adopt random coil conformation with expanded hydrodynamic volume in solution and, consequently, retard kidney filtration in a similar manner as polyethylene glycol (PEG). Relative to unmodified leptin, size exclusion chromatography and dynamic light scattering revealed an approximately 21-fold increase in apparent size and a much larger molecular diameter of around 18 nm for PAS(600)-leptin. High receptor-binding activity for all PASylated leptin versions was confirmed in BIAcore measurements and cell-based dual-luciferase assays. Pharmacokinetic studies in mice revealed a much extended plasma half-life after ip injection, from 26 min for the unmodified leptin to 19.6 h for the PAS(600) fusion. In vivo activity was investigated after single ip injection of equimolar doses of each leptin version. Strongly increased and prolonged hypothalamic STAT3 phosphorylation was detected for PAS(600)-leptin. Also, a reduction in daily food intake by up to 60% as well as loss in body weight of >10% lasting for >5 days was observed, whereas unmodified leptin was merely effective for 1 day. Notably, application of a PASylated superactive mouse leptin antagonist (SMLA) led to the opposite effects. Thus, PASylated leptin not only provides a promising reagent to study its physiological role in vivo but also may offer a superior drug candidate for clinical therapy.

  16. Quality Dimensions, Value, Service Cost and Recommendation Behaviour: Evidence from the Nigerian Cellular Industry

    Directory of Open Access Journals (Sweden)

    Abolaji Joachim Abiodun

    2014-09-01

    Full Text Available The present study proposed and test a model that connects both affective and cognitive factors in cellular service to customers’ recommendation behavior. Results of the analysis of data collected through questionnaire from 293 respondents with cellular phones and active account in the Nigerian cellular industry indicate that core cellular service dimensions, service cost (price and hedonic values are significant determinants of customers’ recommendation behavior. In addition, the study found that customer service and utilitarian value exert negative effect on recommendation behavior. It seems that strengthening the performance of service providers on core service attributes, service cost (price and the entertainment and emotion evoking aspects of cellular service is of more value in partnering with customer to enlarge customer base through recommendation

  17. Results of a search for daily and annual variations of the Po-214 half-life at the two year observation period

    CERN Document Server

    Alexeyev, E N; Gangapshev, A M; Kazalov, V V; Kuzminov, V V; Panasenko, S I; Ratkevich, S S

    2015-01-01

    The brief description of installation TAU-2 intended for long-term monitoring of the half-life value $\\tau$ ($\\tau_{1/2}$) of the $^{214}$Po is presented. The methods of measurement and processing of collected data are reported. The results of analysis of time series values $\\tau$ with different time step are presented. Total of measurement time was equal to 590 days. Averaged value of the $^{214}$Po half-life was obtained $\\tau=163.46\\pm0.04$ $\\mu$s. The annual variation with an amplitude $A=(8.9\\pm2.3)\\cdot10^{-4}$, solar-daily variation with an amplitude $A_{So}=(7.5\\pm1.2)\\cdot10^{-4}$, lunar-daily variation with an amplitude $A_L=(6.9\\pm2.0)\\cdot10^{-4}$ and sidereal-daily variation with an amplitude $A_S=(7.2\\pm1.2)\\cdot10^{-4}$ were found in a series of $\\tau$ values. The maximal values of amplitude are observed at the moments when the projections of the installation Earth location velocity vectors toward the source of possible variation achieve its maximal magnitudes.

  18. Accurate measurements of {sup 129}I concentration by isotope dilution using MC-ICPMS for half-life determination

    Energy Technology Data Exchange (ETDEWEB)

    Isnard, Helene; Nonell, Anthony; Marie, Mylene [Commissariat a l' Energie Atomique et aux Energies alternatives (CEA), Gif Sur Yvette (France). DEN, DPC, SEARS, LANIE; Chartier, Frederic [Commissariat a l' Energie Atomique et aux Energies alternatives (CEA), Gif Sur Yvette (France). DEN, DPC

    2016-05-01

    Determining the {sup 129}I concentration, a long-lived radionuclide present in spent nuclear fuel, is a major issue for nuclear waste disposal purpose. {sup 129}I also has to be measured in numerous environmental, nuclear and biological samples. To be able to accurately determine the {sup 129}I concentration, an analytical method based on the use of a multicollector-inductively coupled plasma mass spectrometer (MC-ICPMS) combined with an isotope dilution technique using an {sup 127}I spike, was developed. First, the influence of different media (HNO{sub 3}, NaOH and TMAH) on natural {sup 127}I signal intensity and stability and on memory effects was studied. Then an analytical procedure was developed by taking into account the correction of blanks and interferences. Tellurium was chosen for instrumental mass bias correction, as no certified standards with suitable {sup 127}I/{sup 129}I ratio are available. Finally, the results, reproducibility and uncertainties obtained for the {sup 129}I concentration determined by isotope dilution with a {sup 127}I spike are presented and discussed. The final expanded relative uncertainty obtained for the iodine-129 concentration was lower than 0.7% (k = 1). This precise {sup 129}I determination in association with further activity measurements of this nuclide on the same sample will render it possible to determine a new value of the {sup 129}I half-life with a reduced uncertainty (0.76%, k = 1).

  19. New limits on Beyond Standard Model physics from a measurement of the half-life of the T=1/2 mirror decay of 19Ne

    CERN Document Server

    Broussard, L; Boswell, M S; Crowell, A S; Dendooven, P; Howell, C R; Kidd, M F; Jungmann, K; Kruithof, W L; Onderwater, C J G; Pattie, R W; Shidling, P D; Sohani, M; van der Hoek, D J; Rogachevskiy, A; Traykov, E; Versolato, O O; Willmann, L; Wilschut, H W; Young, A R

    2013-01-01

    The 1/2+ -> 1/2+ superallowed mixed mirror decay of 19Ne to 19F is excellently suited for high-precision studies of the weak interaction. However, there is some disagreement on the value of the half-life. In a new measurement we have determined this quantity to be T_{1/2} = 17.2832 +/- 0.0051_{(stat)} +/- 0.0066_{(sys)} seconds, which differs from the previous world average by 3 standard deviations. The impact of this measurement on limits for physics beyond the standard model such as the presence of tensor currents is discussed.

  20. Quality Dimensions, Value, Service Cost and Recommendation Behaviour: Evidence from the Nigerian Cellular Industry

    OpenAIRE

    Abolaji Joachim Abiodun; Kenneth Sola Adeyemi; Adewale Omotayo Osibanjo

    2014-01-01

    The present study proposed and test a model that connects both affective and cognitive factors in cellular service to customers’ recommendation behavior. Results of the analysis of data collected through questionnaire from 293 respondents with cellular phones and active account in the Nigerian cellular industry indicate that core cellular service dimensions, service cost (price) and hedonic values are significant determinants of customers’ recommendation behavior. In addition, the study found...

  1. Towards a Measurement of the Half-Life of {sup 60}Fe for Stellar and Early Solar System Models

    Energy Technology Data Exchange (ETDEWEB)

    Ostdiek, K.; Anderson, T.; Bauder, W.; Bowers, M.; Collon, P.; Dressler, R.; Greene, J.; Kutschera, W.; Lu, W.; Paul, M.

    2015-10-15

    Radioisotopes, produced in stars and ejected into the Interstellar Medium, are important for constraining stellar and early Solar System (ESS) models. In particular, the half-life of the radioisotope, Fe-60, can have an impact on calculations for the timing for ESS events, the distance to nearby Supernovae, and the brightness of individual, non-steady-state Fe gamma ray sources in the Galaxy. A half-life measurement has been undertaken at the University of Notre Dame and measurements of the Fe-60/Fe-56 concentration of our samples using Accelerator Mass Spectrometry has begun. This result will be coupled with an activity measurement of the isomeric decay in Co-60, which is the decay product of Fe. Preliminary half-life estimates of (2.53 +/- 0.24) x 10(6) years seem to confirm the recent measurement by Rugel et al. (2009). (C) 2015 Elsevier B.V. All rights reserved.

  2. Half-life of the electron-capture decay of 97Ru: Precision measurement shows no temperature dependence

    CERN Document Server

    Goodwin, J R; Iacob, V E; Hardy, J C; 10.1103/PhysRevC.80.045501

    2009-01-01

    We have measured the half-life of the electron-capture (ec) decay of 97Ru in a metallic environment, both at low temperature (19K), and also at room temperature. We find the half-lives at both temperatures to be the same within 0.1%. This demonstrates that a recent claim that the ec decay half-life for 7Be changes by $0.9% +/- 0.2% under similar circumstances certainly cannot be generalized to other ec decays. Our results for the half-life of 97Ru, 2.8370(14)d at room temperature and 2.8382(14)d at 19K, are consistent with, but much more precise than, previous room-temperature measurements. In addition, we have also measured the half-lives of the beta-emitters 103Ru and 105Rh at both temperatures, and found them also to be unchanged.

  3. Towards a measurement of the half-life of {sup 60}Fe for stellar and early Solar System models

    Energy Technology Data Exchange (ETDEWEB)

    Ostdiek, K.; Anderson, T. [University of Notre Dame, Notre Dame, IN 46556 (United States); Bauder, W. [University of Notre Dame, Notre Dame, IN 46556 (United States); Argonne National Laboratory, 9700 South Cass Avenue, Lemont, IL 60439 (United States); Bowers, M.; Collon, P. [University of Notre Dame, Notre Dame, IN 46556 (United States); Dressler, R. [Paul Scherrer Institute – Laboratory for Radiochemistry and Environmental Chemistry, 5232 Villigen (Switzerland); Greene, J. [Argonne National Laboratory, 9700 South Cass Avenue, Lemont, IL 60439 (United States); Kutschera, W. [Vienna Environmental Research Accelerator Laboratory, Waehringer Strasse 17, 1090 Vienna (Austria); Lu, W. [University of Notre Dame, Notre Dame, IN 46556 (United States); Paul, M. [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel); Robertson, D. [University of Notre Dame, Notre Dame, IN 46556 (United States); Schumann, D. [Paul Scherrer Institute – Laboratory for Radiochemistry and Environmental Chemistry, 5232 Villigen (Switzerland); Skulski, M. [University of Notre Dame, Notre Dame, IN 46556 (United States); Wallner, A. [The Australian National University, Canberra, ACT 0200 (Australia)

    2015-10-15

    Radioisotopes, produced in stars and ejected into the Interstellar Medium, are important for constraining stellar and early Solar System (ESS) models. In particular, the half-life of the radioisotope, {sup 60}Fe, can have an impact on calculations for the timing for ESS events, the distance to nearby Supernovae, and the brightness of individual, non-steady-state {sup 60}Fe gamma ray sources in the Galaxy. A half-life measurement has been undertaken at the University of Notre Dame and measurements of the {sup 60}Fe/{sup 56}Fe concentration of our samples using Accelerator Mass Spectrometry has begun. This result will be coupled with an activity measurement of the isomeric decay in {sup 60}Co, which is the decay product of {sup 60}Fe. Preliminary half-life estimates of (2.53 ± 0.24) × 10{sup 6} years seem to confirm the recent measurement by Rugel et al. (2009).

  4. The half-life of Ascaris lumbricoides prevalence in Japanese school children.

    Science.gov (United States)

    Kurosawa, Carmen Miwa; Ito, Takehiko; Takaki, Jiro; Wang, Bin-Ling; Wang, Da-Hong; Takigawa, Tomoko; Ogino, Keiki

    2008-10-01

    In the present study, we examined the dynamic of school-health-based parasite control and the related socio-economic influences. This is an ecological study based on data from 46 prefectures in Japan. The exponential decay of Ascaris lumbricoides prevalence was calculated by iterative least-squares method. Pearson's correlation and multiple linear regression model analysis were performed to assess the associations between the prevalence of Ascaris lumbricoides in Japanese school children and socio-economic variables such as the prefecture income per capita, the percentage of primary industry, the population density per 1 km2, the diffusion rate of population under water supply, and the percentage of upper secondary school enrollment. The results indicated that the parasite carrier rate was higher in younger students. The half-life of Ascaris lumbricoides prevalence was approximately 3 years with significant variation among prefectures. Multiple regression analyses showed that the decrease of infection in elementary and lower secondary school children had a significant positive association with primary industry and a significant negative association with prefecture income per capita. The school-health-based parasite intervention differs by prefecture and has changed over time according to the respective prefectural stage of economic development.

  5. Kinetic modeling and half life study on bioremediation of crude oil dispersed by Corexit 9500

    Energy Technology Data Exchange (ETDEWEB)

    Zahed, Mohammad Ali [School of Civil Engineering, Universiti Sains Malaysia, Engineering Campus, 14300 Nibong Tebal, Penang (Malaysia); Aziz, Hamidi Abdul, E-mail: cehamidi@eng.usm.my [School of Civil Engineering, Universiti Sains Malaysia, Engineering Campus, 14300 Nibong Tebal, Penang (Malaysia); Isa, Mohamed Hasnain [Civil Engineering Department, Universiti Teknologi PETRONAS, 31750 Tronoh, Perak (Malaysia); Mohajeri, Leila; Mohajeri, Soraya [School of Civil Engineering, Universiti Sains Malaysia, Engineering Campus, 14300 Nibong Tebal, Penang (Malaysia); Kutty, Shamsul Rahman Mohamed [Civil Engineering Department, Universiti Teknologi PETRONAS, 31750 Tronoh, Perak (Malaysia)

    2011-01-30

    Hydrocarbon pollution in marine ecosystems occurs mainly by accidental oil spills, deliberate discharge of ballast waters from oil tankers and bilge waste discharges; causing site pollution and serious adverse effects on aquatic environments as well as human health. A large number of petroleum hydrocarbons are biodegradable, thus bioremediation has become an important method for the restoration of oil polluted areas. In this research, a series of natural attenuation, crude oil (CO) and dispersed crude oil (DCO) bioremediation experiments of artificially crude oil contaminated seawater was carried out. Bacterial consortiums were identified as Acinetobacter, Alcaligenes, Bacillus, Pseudomonas and Vibrio. First order kinetics described the biodegradation of crude oil. Under abiotic conditions, oil removal was 19.9% while a maximum of 31.8% total petroleum hydrocarbons (TPH) removal was obtained in natural attenuation experiment. All DCO bioreactors demonstrated higher and faster removal than CO bioreactors. Half life times were 28, 32, 38 and 58 days for DCO and 31, 40, 50 and 75 days for CO with oil concentrations of 100, 500, 1000 and 2000 mg/L, respectively. The effectiveness of Corexit 9500 dispersant was monitored in the 45 day study; the results indicated that it improved the crude oil biodegradation rate.

  6. High-precision half-life and branching-ratio measurements for superallowed Fermi β+ emitters at TRIUMF – ISAC

    Directory of Open Access Journals (Sweden)

    Laffoley A. T.

    2014-03-01

    Full Text Available A program of high-precision half-life and branching-ratio measurements for superallowed Fermi β emitters is being carried out at TRIUMF’s Isotope Separator and Accelerator (ISAC radioactive ion beam facility. Recent half-life measurements for the superallowed decays of 14O, 18Ne, and 26Alm, as well as branching-ratio measurements for 26Alm and 74Rb are reported. These results provide demanding tests of the Standard Model and the theoretical isospin symmetry breaking (ISB corrections in superallowed Fermi β decays.

  7. Measurement of the Double Beta Decay Half-life of 130Te with the NEMO-3 Detector

    CERN Document Server

    Arnold, R; Baker, J; Barabash, A S; Basharina-Freshville, A; Blondel, S; Bongrand, M; Broudin-Bay, G; Brudanin, V; Caffrey, A J; Chapon, A; Chauveau, E; Durand, D; Egorov, V; Flack, R; Garrido, X; Grozier, J; Guillon, B; Hubert, Ph; Jackson, C M; Jullian, S; Kauer, M; Klimenko, A; Kochetov, O; Konovalov, S I; Kovalenko, V; Lalanne, D; Lamhamdi, T; Lang, K; Liptak, Z; Lutter, G; Mamedov, F; Marquet, Ch; Martin-Albo, J; Mauger, F; Mott, J; Nachab, A; Nemchenok, I; Nguyen, C H; Nova, F; Novella, P; Ohsumi, H; Pahlka, R B; Perrot, F; Piquemal, F; Reyss, J L; Richards, B; Ricol, J S; Saakyan, R; Sarazin, X; Shitov, Yu; Simard, L; Šimkovic, F; Smolnikov, A; Söldner-Rembold, S; Štekl, I; Suhonen, J; Sutton, C S; Szklarz, G; Thomas, J; Timkin, V; Torre, S; Tretyak, V I; Umatov, V; Vála, L; Vanyushin, I; Vasiliev, V; Vorobel, V; Vylov, T; Zukauskas, A

    2011-01-01

    This Letter reports results from the NEMO-3 experiment based on an exposure of 1275 days with 661g of 130Te in the form of enriched and natural tellurium foils. With this data set the double beta decay rate of 130Te is found to be non-zero with a significance of 7.7 standard deviations and the half-life is measured to be T1/2 = (7.0 +/- 0.9(stat) +/- 1.1(syst)) x 10^{20} yr. This represents the most precise measurement of this half-life yet published and the first real-time observation of this decay.

  8. Estimation of biological half-life of tritium in coastal region of India.

    Science.gov (United States)

    Singh, Vishwanath P; Pai, R K; Veerender, D D; Vishnu, M S; Vijayan, P; Managanvi, S S; Badiger, N M; Bhat, H R

    2010-12-01

    The present study estimates biological half-life (BHL) of tritium by analysing routine bioassay samples of radiation workers. During 2007-2009 year, 72,100 urine bioassay samples of the workers were analysed by liquid scintillation counting technique for internal dose monitoring for tritium. Two hundred and two subjects were taken for study with minimum 3 μCiL(-1) tritium uptake in their body fluid. The BHL of tritium of subjects ranges from 1 to 16 d with an average of 8.19 d. Human data indicate that the biological retention time ranges from 4 to 18 d with an average of 10 d. The seasonal variations of the BHL of tritium are 3.09 ± 1.48, 6.87 ± 0.58 and 5.73 ± 0.76 d (mean ± SD) for summer, winter and rainy seasons, respectively, for free water tritium in the coastal region of Karnataka, India, which shows that the BHL in summer is twice that of the winter season. Also three subjects showed the BHL of 101.73-121.09 d, which reveals that organically bound tritium is present with low tritium uptake also. The BHL of tritium for all age group of workers is observed independent of age and is shorter during April to May. The distribution of cumulative probability vs. BHL of tritium shows lognormal distribution with a geometric mean of 9.11 d and geometric standard deviation of 1.77 d. The study of the subjects is fit for two-compartment model and also an average BHL of tritium is found similar to earlier studies.

  9. Extending the Serum Half-Life of G-CSF via Fusion with the Domain III of Human Serum Albumin

    Directory of Open Access Journals (Sweden)

    Shuqiang Zhao

    2013-01-01

    Full Text Available Protein fusion technology is one of the most commonly used methods to extend the half-life of therapeutic proteins. In this study, in order to prolong the half-life of Granulocyte colony stimulating factor (G-CSF, the domain III of human serum albumin (3DHSA was genetically fused to the N-terminal of G-CSF. The 3DHSA-G-CSF fusion gene was cloned into pPICZαA along with the open reading frame of the α-factor signal under the control of the AOX1 promoter. The recombinant expression vector was transformed into Pichia pastoris GS115, and the recombinant strains were screened by SDS-PAGE. As expected, the 3DHSA-G-CSF showed high binding affinity with HSA antibody and G-CSF antibody, and the natural N-terminal of 3DHSA was detected by N-terminal sequencing. The bioactivity and pharmacokinetic studies of 3DHSA-G-CSF were respectively determined using neutropenia model mice and human G-CSF ELISA kit. The results demonstrated that 3DHSA-G-CSF has the ability to increase the peripheral white blood cell (WBC counts of neutropenia model mice, and the half-life of 3DHSA-G-CSF is longer than that of native G-CSF. In conclusion, 3DHSA can be used to extend the half-life of G-CSF.

  10. Brief report : enzyme inducers reduce elimination half-life after a single dose of nevirapine in healthy women

    NARCIS (Netherlands)

    L'homme, R.F.A.; Dijkema, T.; Ven, A.J.A.M. van der; Burger, D.M.

    2006-01-01

    OBJECTIVE: Single-dose nevirapine (SD-NVP) to prevent mother-to-child transmission (MTCT) of HIV is associated with development of NVP resistance, probably because of its long half-life in combination with a low genetic barrier to resistance. The objective of this study was to find enzyme inducers t

  11. Screening and ranking of POPs for global half-life: QSAR approaches for prioritization based on molecular structure.

    Science.gov (United States)

    Gramatica, Paola; Papa, Ester

    2007-04-15

    Persistence in the environment is an important criterion in prioritizing hazardous chemicals and in identifying new persistent organic pollutants (POPs). Degradation half-life in various compartments is among the more commonly used criteria for studying environmental persistence, but the limited availability of experimental data or reliable estimates is a serious problem. Available half-life data for degradation in air, water, sediment, and soil, for a set of 250 organic POP-type chemicals, were combined in a multivariate approach by principal component analysis to obtain a ranking of the studied organic pollutants according to their relative overall half-life. A global half-life index (GHLI) applicable for POP screening purposes is proposed. The reliability of this index was verified in comparison with multimedia model results. This global index was then modeled as a cumulative end-point using a QSAR approach based on few theoretical molecular descriptors, and a simple and robust regression model externally validated for its predictive ability was derived. The application of this model could allow a fast preliminary identification and prioritization of not yet known POPs, just from the knowledge of their molecular structure. This model can be applied a priori also in the chemical design of safer and alternative non-POP compounds.

  12. A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties.

    Directory of Open Access Journals (Sweden)

    Felix Unverdorben

    Full Text Available Half-life extension strategies have gained increasing interest to improve the pharmacokinetic and pharmacodynamic properties of protein therapeutics. Recently, we established an immunoglobulin-binding domain (IgBD from streptococcal protein G (SpGC3 as module for half-life extension. SpGC3 is capable of binding to the Fc region as well as the CH1 domain of Fab arms under neutral and acidic conditions.Using site-directed mutagenesis, we generated a Fab-selective mutant (SpGC3Fab to avoid possible interference with the FcRn-mediated recycling process and improved its affinity for mouse and human IgG by site-directed mutagenesis and phage display selections. In mice, this affinity-improved mutant (SpGC3FabRR conferred prolonged plasma half-lives compared with SpGC3Fab when fused to small recombinant antibody fragments, such as single-chain Fv (scFv and bispecific single-chain diabody (scDb. Hence, the SpGC3FabRR domain seems to be a suitable fusion partner for the half-life extension of small recombinant therapeutics.The half-life extension properties of SpGC3 can be retained by restricting binding to the Fab fragment of serum immunoglobulins and can be improved by increasing binding activity. The modified SpGC3 module should be suitable to extend the half-life of therapeutic proteins and, thus to improve therapeutic activity.

  13. Effective Half-Life of Caesium-137 in Various Environmental Media at the Savannah River Site

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M. H.; Jannik, G. T.; Baker, R. A.

    2014-05-01

    During the operational history of the Savannah River Site (SRS), many different radionuclides have been released from site facilities into the SRS environment. However, only a relatively small number of pathways, most importantly 137Cs in fish and deer, have contributed significantly to doses and risks to the public. The “effective” half-lives (Te) of 137Cs (which include both physical decay and environmental dispersion) in Savannah River floodplain soil and vegetation and in fish and white-tailed deer from the SRS were estimated using long-term monitoring data. For 1974–2011, the Tes of 137Cs in Savannah River floodplain soil and vegetation were 17.0 years (95% CI = 14.2–19.9) and 13.4 years (95% CI = 10.8–16.0), respectively. These Tes were greater than in a previous study that used data collected only through 2005 as a likely result of changes in the flood regime of the Savannah River. Field analyses of 137Cs concentrations in deer collected during yearly controlled hunts at the SRS indicated an overall Te of 15.9 years (95% CI = 12.3–19.6) for 1965–2011; however, the Te for 1990–2011 was significantly shorter (11.8 years, 95% CI = 4.8–18.8) due to an increase in the rate of 137Cs removal. The shortest Tes were for fish in SRS streams and the Savannah River (3.5–9.0 years), where dilution and dispersal resulted in rapid 137Cs removal. Long-term data show that Tes are significantly shorter than the physical half-life of 137Cs in the SRS environment but that they can change over time. Therefore, it is desirable have a long period of record for calculating Tes and risky to extrapolate Tes beyond this period unless the processes governing 137Cs removal are clearly understood.

  14. History of the recommended atomic-weight values from 1882 to 1997: A comparision of differences from current values to the estimated uncertainties of earlier values.

    Science.gov (United States)

    Coplen, T.B.; Peiser, H.S.

    1998-01-01

    International commissions and national committees for atomic weights (mean relative atomic masses) have recommended regularly updated, best values for these atomic weights as applicable to terrestrial sources of the chemical elements. Presented here is a historically complete listing starting with the values in F. W. Clarke's 1882 recalculation, followed by the recommended values in the annual reports of the American Chemical Society's Atomic Weights Commission. From 1903, an International Commission published such reports and its values (scaled to an atomic weight of 16 for oxygen) are here used in preference to those of national committees of Britain, Germany, Spain, Switzerland, and the U.S.A. We have, however, made scaling adjustments from Ar(16O) to Ar(12C) where not negligible. From 1920, this International Commission constituted itself under the International Union of Pure and Applied Chemistry (IUPAC). Since then, IUPAC has published reports (mostly biennially) listing the recommended atomic weights, which are reproduced here. Since 1979, these values have been called the "standard atomic weights" and, since 1969, all values have been published, with their estimated uncertainties. Few of the earlier values were published with uncertainties. Nevertheless, we assessed such uncertainties on the basis of our understanding of the likely contemporary judgement of the values' reliability. While neglecting remaining uncertainties of 1997 values, we derive "differences" and a retrospective index of reliability of atomic-weight values in relation to assessments of uncertainties at the time of their publication. A striking improvement in reliability appears to have been achieved since the commissions have imposed upon themselves the rule of recording estimated uncertainties from all recognized sources of error.

  15. Recommended Parameter Values for INEEL Subsurface Disposal Area Source Release Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Riley, Robert G.; Lopresti, Charles A.

    2004-06-23

    The purpose of this report is to summarize 1) associated information and values for key release model parameters (i.e., best estimate, minimum and maximum) obtained where possible from published experimental data, 2) a structure for selection of sensitivity tests cases that can be used to identify test cases, and 3) recommended test cases for selected contaminants of potential concern to assess remedy effectiveness against a no-treatment base case.

  16. The functional half-life of an mRNA depends on the ribosome spacing in an early coding region

    DEFF Research Database (Denmark)

    Pedersen, Margit; Nissen, Søren; Mitarai, Namiko

    2011-01-01

    supported the model. We thus suggest that translation-rate-mediated differences in the spacing between ribosomes in this early coding region is a parameter that determines the mRNAs functional half-life. We present a model that is in accordance with many earlier observations and that allows a prediction...... codons. When comparing the ribosome spacing at various segments of the mRNA to its functional half-life, we found a clear correlation between the functional mRNA half-life and the ribosome spacing in the mRNA region approximately between codon 20 and codon 45. From this finding, we predicted that inserts......Bacterial mRNAs are translated by closely spaced ribosomes and degraded from the 5'-end, with half-lives of around 2 min at 37 °C in most cases. Ribosome-free or "naked" mRNA is known to be readily degraded, but the initial event that inactivates the mRNA functionally has not been fully described...

  17. Role of ligand-dependent GR phosphorylation and half-life in determination of ligand-specific transcriptional activity.

    Science.gov (United States)

    Avenant, Chanel; Ronacher, Katharina; Stubsrud, Elisabeth; Louw, Ann; Hapgood, Janet P

    2010-10-07

    A central question in glucocorticoid mechanism of action via the glucocorticoid receptor (GR) is what determines ligand-selective transcriptional responses. Using a panel of 12 GR ligands, we show that the extent of GR phosphorylation at S226 and S211, GR half-life and transcriptional response, occur in a ligand-selective manner. While GR phosphorylation at S226 was shown to inhibit maximal transcription efficacy, phosphorylation at S211 is required for maximal transactivation, but not for transrepression efficacy. Both ligand-selective GR phosphorylation and half-life correlated with efficacy for transactivation and transrepression. For both expressed and endogenous GR, in two different cell lines, agonists resulted in the greatest extent of phosphorylation and the greatest extent of GR downregulation, suggesting a link between these functions. However, using phosphorylation-deficient GR mutants we established that phosphorylation of the GR at S226 or S211 does not determine the rank order of ligand-selective GR transactivation. These results are consistent with a model whereby ligand-selective GR phosphorylation and half-life are a consequence of upstream events, such as ligand-specific GR conformations, which are maintained in the phosphorylation mutants.

  18. Only a fraction of patients with ischaemic diseases or diabetes are treated to recommended target values for plasma lipids

    DEFF Research Database (Denmark)

    Siggaard-Andersen, Niels; Freiberg, Jacob J; Nordestgaard, Børge G

    2012-01-01

    We tested the hypothesis that individuals in the general population with and without ischaemic cardiovascular disease, or with diabetes, are treated to recommended target values for plasma lipids.......We tested the hypothesis that individuals in the general population with and without ischaemic cardiovascular disease, or with diabetes, are treated to recommended target values for plasma lipids....

  19. Only a fraction of patients with ischaemic diseases or diabetes are treated to recommended target values for plasma lipids

    DEFF Research Database (Denmark)

    Siggaard-Andersen, Niels; Freiberg, Jacob J; Nordestgaard, Børge G

    2012-01-01

    We tested the hypothesis that individuals in the general population with and without ischaemic cardiovascular disease, or with diabetes, are treated to recommended target values for plasma lipids.......We tested the hypothesis that individuals in the general population with and without ischaemic cardiovascular disease, or with diabetes, are treated to recommended target values for plasma lipids....

  20. Electrosmog in everyday life - Threshold values and recommendations; Elektrosmog im Alltag - Grenzwerte und Empfehlungen

    Energy Technology Data Exchange (ETDEWEB)

    Vogel, E. [Bayerisches Staatsministerium fuer Landesentwicklung und Umweltfragen, Muenchen (Germany)

    1999-11-01

    The publication explains threshold values, emission control policy and legal provisions, the statutory ordinance for protection from electromagnetic fields, DIN standards, relevant building regulations and their implementation. Recommendations of institutions which deviate from those of the ICNRP are discussed as well as the standards applicable in neighbouring countries. Further sources for obtaining specialized information and guidance are mentioned. (orig./CB) [German] Darstellung von Grenzwerten, Immissionsschutz, Verordnung ueber elektromagnetische Felder, DIN-Normen, Bauordnung und deren gesetzmaessige Umsetzung. Diskussion der Empfehlungen kritischer Institutionen und der Standards der Nachbarlaender. Moeglichkeiten zur Beratung durch spezielle Informationsstellen. (orig.)

  1. [Limit values for polycyclic aromatic hydrocarbons in soil of children's playgrounds--basic criteria and recommendations].

    Science.gov (United States)

    Roscher, E; Liebl, B; Schwegler, U; Schmied, R; Kerscher, G

    1996-01-01

    Elevated concentrations of polycyclic aromatic hydrocarbons (PAK) are often found in the soil of former waste disposal sites, industrial areas, etc. It is desirable and useful to determine orientation values to facilitate and unify the evaluation of contaminations under the aspects of present or planned uses of an area, health protection and decision-making on remedial measures. In the present paper we wish to draw attention to, and discuss problems resulting from, particular characteristics of PAK, e.g. the toxicological property "complete carcinogens" or the necessity of taking into account oral, inhalative and dermal exposure of children on a playground. Based on the discussion, orientation values for benzo[a]pyrene and PAK ("normal" pattern) of 0.5 mg/kg soil and 5 mg/kg soil, respectively, are recommended for top soil of vegetation-free playgrounds. In comparison, deductions carried out by other working groups are presented.

  2. Comparative Study of α Half-life of 210Po in Metal Environment at CIAE with a Reference Value

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Qing-zhang; HE; Ming; DONG; Ke-jun; WANG; Xiao-ming; WANG; Wei; RUAN; Xiang-dong; SHEN; Hong-tao; ZHANG; Hui; DOU; Liang; YANG; Xu-ran; XU; Yong-ning; PANG; Yi-jun; WU; Shao-yong; JIANG; Shan

    2015-01-01

    The influence of the electron screening on nuclear processes is studied by many scientists.Within the framework of the Gamow theory,a conventional expression for theαdecay probability is essentially given by the product of two factors:the cluster pre-formation and the penetration probabilities.The former may not affected by the electron screening.The second factor may

  3. IFCC recommendation: The theory of reference values. Part 4. Control of analytical variation in the production, transfer and application of reference values

    OpenAIRE

    Solberg, Helge Erik; Stamm, D.

    1991-01-01

    This paper is the fourth in a series of Recommendations on the Theory of Reference Values. The others cover: Part 1. The Concept of Reference Values [1]. Part 2. Selection of Individuals for the Production of Reference Values [2]. Part 3. Preparation of Individuals and Collection of Specimens for the Production of Reference Values [3]. Part 5. Statistical Treatment of Collected Reference Values. Determination of Reference Limits [4]. Part 6. Presentation of Observed Values Related to Referenc...

  4. Recommended domestic handling of fruits and vegetables to preserve their nutritional value

    Directory of Open Access Journals (Sweden)

    Julio Basulto

    2014-06-01

    Full Text Available The health benefits of daily consumption of at least 5 portions of a variety of fruit and vegetables are well documented. The World Health Organization (WHO public health goal, established in 600 grams per person/day, is not achieved in Spain, so it is important to improve access to these foods, maintain their potential nutritive value and overcome barriers for their consumption. The objectives of this paper are: facilitate responsible decision-making regarding health; maximize the nutritional value of fruit and vegetables, help overcome barriers for fruit and vegetables consumption and report on how their storage at home, their handling and cooking affect to nutritional value of fruit and vegetables.In order to minimize nutrients loss and improve their bioavailability during fruit and vegetables handling, the Association for the promotion of fruit and vegetables “5 a day” (Spain recommends: avoid prolonged storage of fruit and vegetables in the fridge; use layers and outer leaves; peel and/or cut them just before consumption; wash the whole pieces and then chop them; controlling the soaking time of cut pieces; prefer cooking techniques that do not require direct contact with water; a shorter cooking time, less loss of nutrients; the correct frying retains nutrients very well, although it is a technique of which should not be abused; add a few drops of vinegar or lemon juice to the cooking water if it does not change the taste and dish acceptance; use the water of cooking to elaborate other foods (e.g. sauces, soups, purees, etc. except those coming from chard, spinach or beets. The “5 a day” Association (Spain recommends increasing consumption of fruit and vegetables, and state that theloss of nutrients during their home handling should not be understood as a barrier for their consumption.

  5. Innovative methodology for intercomparison of radionuclide calibrators using short half-life in situ prepared radioactive sources

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, P. A. [Centro de Investigação do Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Portugal and Departamento de Física e Astronomia, Faculdade de Ciências da Universidade do Porto (Portugal); Santos, J. A. M., E-mail: joao.santos@ipoporto.min-saude.pt [Centro de Investigação do Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto (Portugal); Serviço de Física Médica do Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto (Portugal); Serviço de Medicina Nuclear do Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto (Portugal); Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto (Portugal)

    2014-07-15

    Purpose: An original radionuclide calibrator method for activity determination is presented. The method could be used for intercomparison surveys for short half-life radioactive sources used in Nuclear Medicine, such as{sup 99m}Tc or most positron emission tomography radiopharmaceuticals. Methods: By evaluation of the resulting net optical density (netOD) using a standardized scanning method of irradiated Gafchromic XRQA2 film, a comparison of the netOD measurement with a previously determined calibration curve can be made and the difference between the tested radionuclide calibrator and a radionuclide calibrator used as reference device can be calculated. To estimate the total expected measurement uncertainties, a careful analysis of the methodology, for the case of{sup 99m}Tc, was performed: reproducibility determination, scanning conditions, and possible fadeout effects. Since every factor of the activity measurement procedure can influence the final result, the method also evaluates correct syringe positioning inside the radionuclide calibrator. Results: As an alternative to using a calibrated source sent to the surveyed site, which requires a relatively long half-life of the nuclide, or sending a portable calibrated radionuclide calibrator, the proposed method uses a source preparedin situ. An indirect activity determination is achieved by the irradiation of a radiochromic film using {sup 99m}Tc under strictly controlled conditions, and cumulated activity calculation from the initial activity and total irradiation time. The irradiated Gafchromic film and the irradiator, without the source, can then be sent to a National Metrology Institute for evaluation of the results. Conclusions: The methodology described in this paper showed to have a good potential for accurate (3%) radionuclide calibrators intercomparison studies for{sup 99m}Tc between Nuclear Medicine centers without source transfer and can easily be adapted to other short half-life radionuclides.

  6. Phenobarbital administration every eight hours: improvement of seizure management in idiopathic epileptic dogs with decreased phenobarbital elimination half-life.

    Science.gov (United States)

    Stabile, F; Barnett, C R; De Risio, L

    2017-02-18

    Estimated prevalence of canine idiopathic epilepsy is 0.6 per cent in the first-opinion canine population in the UK. Phenobarbital monotherapy has been reported to reduce/eradicate seizure activity in 60-93 per cent of idiopathic epileptic dogs (IEDs). The objective of this study was to evaluate safety and efficacy of the administration of phenobarbital orally every eight hours in IEDs with phenobarbital elimination half-life less than 20 hours. Medical records of 10 IEDs in which steady state trough serum phenobarbital levels were within the reference range and phenobarbital elimination half-life had become less than 20 hours following prolonged administration every 12 hours were reviewed. Side effects and seizure frequency when phenobarbital was administered every 12 hours or 8 hours were compared. In all dogs the side effects of the antiepileptic medication treatment improved. When phenobarbital was administered every eight hours, 9/10 dogs experienced improvement in seizure frequency and 8/10 dogs maintained seizure freedom for a period three times longer than the longest interictal interval period previously recorded. Reduction in the severity and number of clusters of seizures was recorded in one of the remaining two dogs. The administration of phenobarbital orally every eight hours in IEDs with decreased phenobarbital elimination half-life appears safe and can improve seizure management. The results of this study were presented in abstract form (poster) for the 28th symposium of the European Society of Veterinary Neurology - European College of Veterinary Neurology (ESVN), September 18-19, 2015, Amsterdam, Netherlands. British Veterinary Association.

  7. Measurement of the half-life of 198Au in a non-metal: High-precision measurement shows no host-material dependence

    CERN Document Server

    Goodwin, J R; Iacob, V E; Dibidad, A; Hardy, J C

    2010-01-01

    We have measured the half-life of the beta decay of 198Au to be 2.6948(9) d, with the nuclide sited in an insulating environment. Comparing this result with the half-life we measured previously with a metallic environment, we find the half-lives in both environments to be the same within 0.04%, thus contradicting a prediction that screening from a "plasma" of quasi-free electrons in a metal increases the half-life by as much as 7%.

  8. Recommendations to improve wildlife exposure estimation for development of soil screening and cleanup values.

    Science.gov (United States)

    Sample, Bradley E; Schlekat, Chris; Spurgeon, David J; Menzie, Charlie; Rauscher, Jon; Adams, Bill

    2014-07-01

    An integral component in the development of media-specific values for the ecological risk assessment of chemicals is the derivation of safe levels of exposure for wildlife. Although the derivation and subsequent application of these values can be used for screening purposes, there is a need to identify the threshold for effects when making remedial decisions during site-specific assessments. Methods for evaluation of wildlife exposure are included in the US Environmental Protection Agency (USEPA) ecological soil screening levels (Eco-SSLs), registration, evaluation, authorization, and restriction of chemicals (REACH), and other risk-based soil assessment approaches. The goal of these approaches is to ensure that soil-associated contaminants do not pose a risk to wildlife that directly ingest soil, or to species that may be exposed to contaminants that persist in the food chain. These approaches incorporate broad assumptions in the exposure and effects assessments and in the risk characterization process. Consequently, thresholds for concluding risk are frequently very low with conclusions of risk possible when soil metal concentrations fall in the range of natural background. A workshop held in September, 2012 evaluated existing methods and explored recent science about factors to consider when establishing appropriate remedial goals for concentrations of metals in soils. A Foodweb Exposure Workgroup was organized to evaluate methods for quantifying exposure of wildlife to soil-associated metals through soil and food consumption and to provide recommendations for the development of ecological soil cleanup values (Eco-SCVs) that are both practical and scientifically defensible. The specific goals of this article are to review the current practices for quantifying exposure of wildlife to soil-associated contaminants via bioaccumulation and trophic transfer, to identify potential opportunities for refining and improving these exposure estimates, and finally, to make

  9. Real-time RT-PCR analysis of mRNA decay: half-life of Beta-actin mRNA in human leukemia CCRF-CEM and Nalm-6 cell lines

    Directory of Open Access Journals (Sweden)

    Barredo Julio C

    2002-03-01

    Full Text Available Abstract Background We describe an alternative method to determine mRNA half-life (t1/2 based on the Real-Time RT-PCR procedure. This approach was evaluated by using the β-actin gene as a reference molecule for measuring of mRNA stability. Results Human leukemia Nalm-6 and CCRF-CEM cells were treated with various concentrations of Actinomycin D to block transcription and aliquots were removed periodically. Total RNA was isolated and quantified using the RiboGreen® fluorescent dye with the VersaFluor Fluorometer System. One μg of total RNA was reverse transcribed and used as template for the amplification of a region of the β-actin gene (231 bp. To generate the standard curve, serial ten-fold dilutions of the pBactin-231 vector containing the cDNA amplified fragment were employed, β-actin mRNAs were quantified by Real-Time RT-PCR using the SYBR® Green I fluorogenic dye and data analyzed using the iCycle iQ system software. Using this method, the β-actin mRNA exhibited a half-life of 6.6 h and 13.5 h in Nalm-6 and CCRF-CEM cells, respectively. The t1/2 value obtained for Nalm-6 is comparable to those estimated from Northern blot studies, using normal human leukocytes (5.5 h. Conclusions We have developed a rapid, sensitive, and reliable method based on Real-Time RT-PCR for measuring mRNA half-life. Our results confirm that β-actin mRNA half-life can be affected by the cellular growth rate.

  10. Dual Constant Domain-Fab: A novel strategy to improve half-life and potency of a Met therapeutic antibody.

    Science.gov (United States)

    Cignetto, Simona; Modica, Chiara; Chiriaco, Cristina; Fontani, Lara; Milla, Paola; Michieli, Paolo; Comoglio, Paolo M; Vigna, Elisa

    2016-06-01

    The kinase receptor encoded by the Met oncogene is a sensible target for cancer therapy. The chimeric monovalent Fab fragment of the DN30 monoclonal antibody (MvDN30) has an odd mechanism of action, based on cell surface removal of Met via activation of specific plasma membrane proteases. However, the short half-life of the Fab, due to its low molecular weight, is a severe limitation for the deployment in therapy. This issue was addressed by increasing the Fab molecular weight above the glomerular filtration threshold through the duplication of the constant domains, in tandem (DCD-1) or reciprocally swapped (DCD-2). The two newly engineered molecules showed biochemical properties comparable to the original MvDN30 in vitro, acting as full Met antagonists, impairing Met phosphorylation and activation of downstream signaling pathways. As a consequence, Met-mediated biological responses were inhibited, including anchorage-dependent and -independent cell growth. In vivo DCD-1 and DCD-2 showed a pharmacokinetic profile significantly improved over the original MvDN30, doubling the circulating half-life and reducing the clearance. In pre-clinical models of cancer, generated by injection of tumor cells or implant of patient-derived samples, systemic administration of the engineered molecules inhibited the growth of Met-addicted tumors.

  11. In vitro digestion kinetics of excipients for lipid-based drug delivery and introduction of a relative lipolysis half life.

    Science.gov (United States)

    Arnold, Yvonne E; Imanidis, Georgios; Kuentz, Martin

    2012-10-01

    Lipid-based drug delivery systems are widely used for enhancing the solubility of poorly water soluble drugs in the gastro-intestinal tract. Following oral intake, lipid systems undergo digestion in the stomach as well as the intestine. Lipolysis is here a complex process at the oil/water interface, influenced by numerous factors. To study the digestibility of nine excipients often used in lipid-based drug delivery systems. In addition, we introduced a mathematical model to describe in vitro lipolysis kinetics. A relative lipolysis half life was defined using the reference excipient medium-chain triglycerides. Using pH-stat equipment, the NaOH consumption was determined in an in vitro lipolysis assay. We identified two classes of excipients. Some additives were partially hydrolysed, whereas other excipients displayed complete lipolysis. For the latter class, a simplified mathematical model provided a good first approximation of initial lipolysis kinetics. Digestion characterization of excipients is important for the development of lipid-based delivery systems. The applied kinetic model and the concept of a relative lipolysis half life seemed to be promising tools for comparing in vitro lipolysis results.

  12. Use of daily detector verification data for isotopical half-life determination

    Energy Technology Data Exchange (ETDEWEB)

    Goncalves, Vitor C.; Zahn, Guilherme S.; Genezini, Frederico A.; Ticianelli, Regina B.; Saiki, Mitiko [Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP. P.O. Box 11049, Sao Paulo, 05422-970 (Brazil)

    2013-05-06

    In this work, the possibility of using data fromthe daily detector verification routines performed at the Neutron Activation Laboratory of IPEN to determine precise values for the half-lives of {sup 57}Co and {sup 60}Co was evaluated. For this purpose data from 4 of the laboratory's detectors, some spanning for more than 9 years, were inspected, separated in consistent groups, and then analyzed using a robust least-squares fit procedure in order to determine the half-lives. The results allowed for a discussion on the possibilities and limitations of the use of these data for the determination of half-lives.

  13. Investigations of short half-life states from SF of {sup 252}Cf

    Energy Technology Data Exchange (ETDEWEB)

    Fong, D.; Hwang, J.K.; Ramayya, A.V.; Hamilton, J.H.; Beyer, C.J.; Li, K.; Gore, P.M.; Jones, E.F.; Luo, Y.X. [Vanderbilt University, Physics Department, Nashville, TN (United States); Rasmussen, J.O.; Wu, S.C.; Lee, I.Y.; Fallon, P.; Ginter, T.N. [Lawrence Berkeley National Laboratory, Berkeley, CA (United States); Zhu, S.J. [Tsinghua University, Department of Physics, Beijing (China); Stoyer, M.A.; Asztalos, S.J. [Lawrence Livermore National Laboratory, Livermore, CA (United States); Cole, J.D. [Idaho National Engineering and Environmental Laboratory, Idaho Falls, ID (United States); Ter-Akopian, G.M.; Daniel, A. [Joint Institute for Nuclear Research, Flerov Laboratory for Nuclear Reactions, Dubna (Russian Federation)

    2005-09-01

    By using different time-gated triple {gamma} coincidence data, the half-lives (T{sub 1/2}) of several short lived states in neutron-rich nuclei have been studied. The first excited states in the ground state bands often decay by delayed {gamma} emission. By creating triple {gamma} coincidence spectra with time windows of 8, 16, 20, 28, and 48 ns, we have studied states with half-lives below 10 ns. The estimated half-lives of {sup 102}Zr, {sup 137}Xe, and {sup 143}Ba are in reasonable agreement with previously reported values. We extract the first estimates of the half lives of the 2{sup +} states in {sup 104}Zr and {sup 152}Ce. (orig.)

  14. Analytical expression for the α-decay half-life and understanding the data including very long life-times and superheavy nuclei

    Science.gov (United States)

    Sahu, Basudeb

    2008-10-01

    An analytically solvable composite potential that can closely reproduce the combined potential of an α+nucleus system consisting of attractive nuclear and repulsive electrostatic potentials is developed. The exact s-wave solution of the Schrödinger equation with this potential in the interior region and the outside Coulomb wave function are used to give a heuristic expression for the width or half-life of the quasibound state at the accurately determined resonance energy, called the Q value of the decaying system. By using the fact that for a relatively low resonance energy, the quasibound state wave function is quite similar to the bound state wave function where the amplitude of the wave function in the interaction region is very large as compared to the amplitude outside, the resonance energy could easily be calculated from the variation of relative probability densities of inside and outside waves as a function of energy. By considering recent α-decay systems, the applicability of the model is demonstrated with excellent explanations being found for the experimental data of Q values and half-lives of a vast range of masses including superheavy nuclei and nuclei with very long lifetimes (of order 1022 s). Throughout the application, by simply varying the value of a single potential parameter describing the flatness of the barrier, we obtain successful results in cases with as many as 70 pairs of α+daughter nucleus systems.

  15. Interests and values in the Recommended Dietary Allowances and nutritional guidelines for Americans.

    Science.gov (United States)

    Kunkel, H O

    1996-09-01

    Evidence is provided showing that interests, values and belief systems have affected the development of Recommended Dietary Allowances (RDAs) and nutrition guidelines for Americans in the past and can be expected to do so in the future. The conflicts of the 1980s relative to the nutritional guidelines for Americans and the RDAs illustrate the tension among values that can parallel a conflict of interests. In the conflicts of the 1980s, we saw an apparent conflict between those policies that attempt to optimize outcomes for a large class of affected parties and those policies that attempt to establish constraints on actions which appear to threaten individual autonomy and freedom of choice. The former approach derives from utilitarian, consequential moral philosophy which evaluates policies by evaluating costs and harms, and weighing them against benefits to all parties. The latter has its strongest advocates in contemporary libertarianism which takes individual freedom to be the bottom line. Ethical vegetarianism, a belief system which would limit RDAs and guidelines to those that can be translated to vegan and other vegetarian diets, has been a more recent entry into the discussions. Such human value issues suggest that a set of RDAs or of nutrition guidelines is analogous to and may be considered to be an ethic. An ethic is a theory reached via the method of reflective equilibrium that is a coherent ordered triple set of beliefs: a set of considered moral judgments, a set of moral principles, and a set of relevant scientific background theories. The reasoning, however, can become circular and unsound when the considered moral judgments, moral principles and relevant background are not independent sources of information. If they are mixed or, for example, an intuition is mistaken for a scientific conclusion, the reasoning can be flawed.

  16. An Advance in Prescription Opioid Vaccines: Overdose Mortality Reduction and Extraordinary Alteration of Drug Half-Life.

    Science.gov (United States)

    Kimishima, Atsushi; Wenthur, Cody J; Zhou, Bin; Janda, Kim D

    2017-01-20

    Prescription opioids (POs) such as oxycodone and hydrocodone are highly effective medications for pain management, yet they also present a substantial risk for abuse and addiction. The consumption of POs has been escalating worldwide, resulting in tens of thousands of deaths due to overdose each year. Pharmacokinetic strategies based upon vaccination present an attractive avenue to suppress PO abuse. Herein, the preparation of two active PO vaccines is described that were found to elicit high-affinity antiopioid antibodies through a structurally congruent drug-hapten design. Administration of these vaccines resulted in a significant blockade of opioid analgesic activity, along with an unprecedented increase in drug serum half-life and protection against lethal overdose.

  17. 209Tl half-life and gamma-ray measurements of radionuclides belonging to the (4 n + 1) decay chain

    Science.gov (United States)

    Ardisson, G.; Barci, V.; El Samad, O.

    1994-01-01

    Gamma-ray spectra of radiochemically separated 221Fr, 213Bi and 209Tl sources were measured using coaxial and planar HPGe detectors. The energies and emission probabilities of eight new gamma-ray transitions were observed in the decay of 209Tl; a half-life of (2.161±0.007) min was measured. Twenty-two gamma-rays have been attributed to the β-decay of 213Bi, of which 17 are new with respect to previous studies. The 213Po level scheme was determined using γ-γ coincidence measurements: eight excited states are proposed of which six are new. Preliminary measurements of the α-decay of 221Fr revealed the existence of 18 gamma-ray transitions of which eight are reported for the first time.

  18. KINETIC MODELLING AND HALF LIFE STUDY OF ADSORPTIVE BIOREMEDIATION OF SOIL ARTIFICIALLY CONTAMINATED WITH BONNY LIGHT CRUDE OIL

    Directory of Open Access Journals (Sweden)

    Samuel Enahoro Agarry

    2015-06-01

    Full Text Available In this study, comparative potential effects of commercial activated carbon (CAC and plantain peel-derived biochar (PPBC of different particle sizes and dosage to stimulate petroleum hydrocarbon biodegradation in soil were investigated. Microcosms containing soil were spiked with weathered Bonny light crude oil (WBLCO (10% w/w and amended with different particle sizes (0.02, 0.07 and 0.48 mm and dosage (20, 30 and 40 g of CAC and PPBC, respectively. The bioremediation experiments were carried out for a period of 28 days under laboratory conditions. The results showed that there was a positive relationship between the rate of petroleum hydrocarbons reduction and presence of the CAC and PPBC in crude oil contaminated soil microcosms. The WBLCO biodegradation data fitted well to the first-order kinetic model. The model revealed that WBLCO contaminated-soil microcosms amended with CAC and PPBC had higher biodegradation rate constants (k as well as lower half-life times (t1/2 than unamended soil (natural attenuation remediation system. The rate constants increased while half-life times decreased with decreased particle size and increased dosage of amendment agents. ANOVA statistical analysis revealed that WBLCO biodegradation in soil was significantly (p = 0.05 influenced by the addition of CAC and biochar amendment agents, respectively. However, Tukey’s post hoc test (at p = 0.05 showed that there was no significant difference in the bioremediation efficiency of CAC and PPBC. Thus, amendment of soils with biochar has the potential to be an inexpensive, efficient, environmentally friendly and relatively novel strategy to mitigate organic compound-contaminated soil.

  19. Precision measurement of the half-life and branching ratio of the T=1/2 mirror $\\beta$-decay of $^{37}$K

    CERN Multimedia

    We propose to study the T=1/2 mirror $\\beta$-decay of $^{37}$K. Nuclear mirror $\\beta$-decay is a competitive means to test the electroweak model by means of the high-precision measurement of V$_{ud}$ element of the CKM quark mixing matrix. One key ingredient to obtain V$_{ud}$ is the force of the transition, Ft, which has to be determined with a relative precision below 10$^{−3}$. This quantity is related to the half-life T$_{1/2}$ of the decaying nucleus, the branching ratio BR for this decay and the mass difference between the mother and daughter nucleus (Q value). Another important feature is the mixing ratio $\\rho$ between the Fermi and the Gamow-Teller character of the transition. In most cases, $\\rho$ is the major contributor to the uncertainty on Ft. Available data concerning T$_{1/2}$ and BR of $^{37}$K suffer from a lack of precision that will be easily reduced by a dedicated experiment.

  20. Neutron activation of natural materials in a PWR spectrum: feedback on {sup 116m}In relative γ emission intensities and half-life

    Energy Technology Data Exchange (ETDEWEB)

    Gruel, Adrien; Geslot, Benoit; Di Salvo, Jacques; Blaise, Patrick; Girard, Jean-Michel; Destouches, Christophe [CEA, DEN, SPEx, Cadarache, F-13108 St Paul lez Durance (France)

    2015-07-01

    During the MAESTRO program, carried out between 2011 and 2014 in MINERVE zero power reactor, common Gen-II and Gen-III light water reactor materials were irradiated. For some of these materials, the decay of their activation products was also measured by γ spectrometry. Initially devoted to the measurement of the integral capture cross section by activation and reactivity-oscillation method, these results can also provide useful information on decay data of various radionuclides. This approach of this experiment led to a common roadmap shared by the Experimental Physics Section and the Henri Becquerel National Laboratory to improve decay data in nuclear data libraries. Results discussed in this paper concern the relative emission intensities of the main γ rays of {sup 116m}In. Six irradiations of samples with various physical forms of {sup nat}In were carried out. Measurements were analyzed using decay data from several evaluations and it is shown that γ ray activities are not consistent. Analyses were carried out to provide new relative γ emission intensities from these measurements. The {sup 116m}In half-life has also been measured and shows a good agreement with existing values. Finally, an overview of the foreseen results on additional decay data from the MAESTRO program is given. (authors)

  1. Measurement of the two neutrino double beta decay half-life of Zr-96 and search for associated neutrinoless processes with the NEMO-3 detector

    CERN Document Server

    Argyriades, J; Augier, C; Baker, J; Barabash, A S; Bongrand, M; Broudin-Bay, G; Brudanin, V B; Caffrey, A J; Chapon, A; Chauveau, E; Daraktchieva, Z; Durand, D; Egorov, V G; Fatemi-Ghomi, N; Flack, R; Freshville, A; Guillon, B; Hubert, Ph; Jullian, S; Kauer, M; King, S; Kochetov, O I; Konovalov, S I; Kovalenko, V E; Lalanne, D; Lang, K; Lemiere, Y; Lutter, G; Mamedov, F; Marquet, Ch; Martín-Albo, J; Mauger, F; Nachab, A; Nasteva, I; Nemchenok, I B; Nova, F; Novella, P; Ohsumi, H; Pahlka, R B; Perrot, F; Piquemal, F; Reyss, J L; Ricol, J S; Saakyan, R; Sarazin, X; Simard, L; Shitov, Yu A; Smolnikov, A A; Snow, S; Söldner-Rembold, S; Stekl, I; Sutton, C S; Szklarz, G; Thomas, J; Timkin, V V; Tretyak, V I; Tretyak, Vl I; Umatov, V I; Vàla, L; Vanyushin, I A; Vasiliev, V A; Vorobel, V; Vylov, Ts

    2009-01-01

    Using 1221 days of data from the NEMO-3 detector, the measurement of Zr-96 2vbb decay half-life is [2.35 +/- 0.14(stat) +/- 0.19(syst)] x 10^19 yr. Different characteristics of the final state electrons have been studied, such as the energy sum, individual electron energy, and angular distribution. The 2v nuclear matrix element is extracted using the measured 2vbb half-life and is 0.049 +/- 0.003. A 90% CL limit is set on the 0vbb decay half-life of > 9.2 x 10^21 yr corresponding to a limit on the effective Majorana neutrino mass < 7.2 - 19.5 eV. Limits on other mechanisms of 0vbb decay have also been set.

  2. Perfluorooctane Sulfonate Plasma Half-Life Determination and Long-Term Tissue Distribution in Beef Cattle (Bos taurus).

    Science.gov (United States)

    Lupton, Sara J; Dearfield, Kerry L; Johnston, John J; Wagner, Sarah; Huwe, Janice K

    2015-12-30

    Perfluorooctane sulfonate (PFOS) is used in consumer products as a surfactant and is found in industrial and consumer waste, which ends up in wastewater treatment plants (WWTPs). PFOS does not breakdown during WWTP processes and accumulates in the biosolids. Common practices include application of biosolids to pastures and croplands used for feed, and as a result, animals such as beef cattle are exposed to PFOS. To determine plasma and tissue depletion kinetics in cattle, 2 steers and 4 heifers were dosed with PFOS at 0.098 mg/kg body weight and 9.1 mg/kg, respectively. Plasma depletion half-lives for steers and heifers were 120 ± 4.1 and 106 ± 23.1 days, respectively. Specific tissue depletion half-lives ranged from 36 to 385 days for intraperitoneal fat, back fat, muscle, liver, bone, and kidney. These data indicate that PFOS in beef cattle has a sufficiently long depletion half-life to permit accumulation in edible tissues.

  3. Plasma half-life and organ uptake ratio of radiolabeled glandular kallikrein in control and nephrectomized rats

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, K.; Iwata, T.; Kokubu, T.

    1986-01-01

    The purified rat urinary kallikrein was radiolabeled by lactoperoxidase method and by chloramine T method. Plasma half-life of radiolabeled kallikrein was 5.06 +/- 0.59 (n = 5) min in control rats and 5.24 +/- 0.42 (n = 5) min in nephrectomized rats. There was no difference between two groups. From autoradiogram, main metabolic organs of radiolabeled kallikrein were liver, kidney and spleen. Total uptake of radiolabeled kallikrein in ech organ was the highest in liver (73.2%). The uptake per g tissue of radiolabeled kallikrein in each organ was high in liver (33.0%), kidney (31.4%) and spleen (21.1%). These results suggest that the active kallikrein is metabolized mainly in the liver, and kidney is not so an important organ to metabolize or to eliminate the active kallikrein in plasma. In order to clarify the mode of existence of active kallikrein in plasma, the following experiment was done by using disc gel electrophoresis. Radioactive profile of radiolabeled kallikrein showed one peak (Rf = 1.0), but radiolabeled kallikrein mixed with rat plasma showed two peaks, that is small peak (Rf = 1.0), and main peak (RF = 0.5). The most of radiolabeled kallikrein was bound to plasma protein and only five per cent was in free form. Furthermore, the binding of radiolabeled kallikrein to plasma protein was interfered by the addition of active kallikrein. These results suggest the possibility of existence of kallikrein binding protein in plasma.

  4. Use of short half-life cosmogenic isotopes to quantify sediment mixing and transport in karst conduits

    Science.gov (United States)

    Paylor, R.

    2011-12-01

    Particulate inorganic carbon (PIC) transport and flux in karst aquifers is poorly understood. Methods to quantify PIC flux are needed in order to account for total inorganic carbon removal (chemical plus mechanical) from karst settings. Quantifying PIC flux will allow more accurate calculations of landscape denudation and global carbon sink processes. The study concentrates on the critical processes of the suspended sediment component of mass flux - surface soil/stored sediment mixing, transport rates and distance, and sediment storage times. The primary objective of the study is to describe transport and mixing with the resolution of single storm-flow events. To quantify the transport processes, short half-life cosmogenic isotopes are utilized. The isotopes 7Be (t1/2 = 53d) and 210Pb (t1/2 = 22y) are the primary isotopes measured, and other potential isotopes such as 137Cs and 241Am are investigated. The study location is at Mammoth Cave National Park within the Logsdon River watershed. The Logsdon River conduit is continuously traversable underground for two kilometers. Background levels and input concentrations of isotopes are determined from soil samples taken at random locations in the catchment area, and suspended sediment collected from the primary sinking stream during a storm event. Suspended sediment was also collected from the downstream end of the conduit during the storm event. After the storm flow receded, fine sediment samples were taken from the cave stream at regular intervals to determine transport distances and mixing ratios along the conduit. Samples were analyzed with a Canberra Industries gamma ray spectrometer, counted for 24 hours to increase detection of low radionuclide activities. The measured activity levels of radionuclides in the samples were adjusted for decay from time of sampling using standard decay curves. The results of the study show that surface sediment mixing, transport and storage in karst conduits is a dynamic but

  5. Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells.

    Science.gov (United States)

    Sharova, Lioudmila V; Sharov, Alexei A; Nedorezov, Timur; Piao, Yulan; Shaik, Nabeebi; Ko, Minoru S H

    2009-02-01

    Degradation of mRNA is one of the key processes that control the steady-state level of gene expression. However, the rate of mRNA decay for the majority of genes is not known. We successfully obtained the rate of mRNA decay for 19 977 non-redundant genes by microarray analysis of RNA samples obtained from mouse embryonic stem (ES) cells. Median estimated half-life was 7.1 h and only genes, including Prdm1, Myc, Gadd45 g, Foxa2, Hes5 and Trib1, showed half-life less than 1 h. In general, mRNA species with short half-life were enriched among genes with regulatory functions (transcription factors), whereas mRNA species with long half-life were enriched among genes related to metabolism and structure (extracellular matrix, cytoskeleton). The stability of mRNAs correlated more significantly with the structural features of genes than the function of genes: mRNA stability showed the most significant positive correlation with the number of exon junctions per open reading frame length, and negative correlation with the presence of PUF-binding motifs and AU-rich elements in 3'-untranslated region (UTR) and CpG di-nucleotides in the 5'-UTR. The mRNA decay rates presented in this report are the largest data set for mammals and the first for ES cells.

  6. Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells

    Science.gov (United States)

    Sharova, Lioudmila V.; Sharov, Alexei A.; Nedorezov, Timur; Piao, Yulan; Shaik, Nabeebi; Ko, Minoru S.H.

    2009-01-01

    Degradation of mRNA is one of the key processes that control the steady-state level of gene expression. However, the rate of mRNA decay for the majority of genes is not known. We successfully obtained the rate of mRNA decay for 19 977 non-redundant genes by microarray analysis of RNA samples obtained from mouse embryonic stem (ES) cells. Median estimated half-life was 7.1 h and only <100 genes, including Prdm1, Myc, Gadd45 g, Foxa2, Hes5 and Trib1, showed half-life less than 1 h. In general, mRNA species with short half-life were enriched among genes with regulatory functions (transcription factors), whereas mRNA species with long half-life were enriched among genes related to metabolism and structure (extracellular matrix, cytoskeleton). The stability of mRNAs correlated more significantly with the structural features of genes than the function of genes: mRNA stability showed the most significant positive correlation with the number of exon junctions per open reading frame length, and negative correlation with the presence of PUF-binding motifs and AU-rich elements in 3′-untranslated region (UTR) and CpG di-nucleotides in the 5′-UTR. The mRNA decay rates presented in this report are the largest data set for mammals and the first for ES cells. PMID:19001483

  7. Half-life and rational drug use of paclitaxel%紫杉醇的半衰期与合理用药

    Institute of Scientific and Technical Information of China (English)

    陈素虹

    2015-01-01

    In this article,the author mainly discusses the relationship of paclitaxel drug metabolism in human body and its half-life to promote its rational drug use.Refer to the relevant medical literature at home and abroad in recent years,we have induction and summary.The relationship of paclitaxel half-life and pesticide effect is analyzed.The paclitaxel half-life can determine the metabolism degree of the drug in the body,so drug half-life plays a critical role in the process of rational drug use.%本文主要对紫杉醇药物在人体内的代谢与其半衰期的关系进行探讨,以促进其合理用药。笔者参阅近几年来国内外的相关医学文献,进行归纳、总结,分析紫杉醇半衰期与药效之间的关系。根据紫杉醇的半衰期可以判定药物在人体内的代谢程度,因此药物半衰期在合理用药的过程中发挥着至关重要的作用。

  8. Platelet half-life in patients with primary hyperlipoproteinemia type IIa, IIb, and IV according to Fredrickson with and without clinical signs of atherosclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Jaeger, E.; Sinzinger, H.; Widhalm, K.; Kaliman, J.; Hoefer, R. (Vienna Univ. (Austria). 2. Medizinische Klinik; Ludwig Boltzmann-Institut fuer Nuklearmedizin, Vienna (Austria); Vienna Univ. (Austria). Kinderklinik; Vienna Univ. (Austria). Kardiologische Klinik)

    1982-09-01

    It is generally accepted that platelet half-life is shortened in atherosclerotic vascular diseases. Concerning changes due to hyperlipoproteinemia (HLP), however, there exist only few data. Therefore, we examined the platelet-half life in 60 patients with recently discovered HLP type IIa, IIb and IV according to Fredrickson before treatment in comparison to 60 controls. 33 of the HLP-patients had no clinical symptoms of angiopathy. 27 patients suffered from peripheral vascular disease or from coronary heart disease as verified by angiography. The labelling of autologous platelets was performed with 100..mu..Ci of /sup 111/Indium-oxine-sulfate at 37/sup 0/C for 5 minutes. The mean labelling efficiency was 90%, the recovery after 2 hours about 70%. Serum lipoproteins were estimated by means of ultracentrifugation and polyanionprecipitation according to Lipid Research Clinic Methods. In the patients with HLP platelet half-life was significantly shortened in comparison to the control group (p < 0.01). These changes were most pronounced in patients with HLP-type IIa and with atherosclerotic lesions, respectively. In patients with HLP-type IIa a very close correlation could be demonstrated between platelet half-life and LDL-cholesterol (r = -0.72; p < 0.001) as well as total cholesterol (r = -0.73; p < 0.001). These data prove that in HLP in-vivo platelet function as measured by platelet survival is significantly influenced even before the occurrence of clinically relevant symptoms of atherosclerosis.

  9. 基于下载量的期刊半衰期实证研究%Empirical Research on Half-life Period of Journals Based on Downloads

    Institute of Scientific and Technical Information of China (English)

    许新军

    2014-01-01

    针对期刊网络老化速度研究较为薄弱的状况,以CNKI为数据源,通过对图书馆学情报学期刊下载量半衰期的实证分析研究,解读了下载量半衰期的特点,剖析了其与其它期刊评价指标的区别与联系。结果显示:期刊下载量半衰期明显小于被引半衰期和引用半衰期,与被引半衰期之间存在显著的相关性;与期刊其它计量指标相比有其特质与独立性;开展期刊下载量半衰期研究,有利于突破老化研究中引文分析的藩篱,提升期刊评价的时效性,拓展考察范围及促进期刊出版机构主动缩短网络版与印刷版之间的出版时滞,对期刊整体影响力的提升将产生积极影响。%Aimed at the unsubstantial research on aging speed of network periodicals and taking CNKI as data source, the paper interprets the characteristics of half-life period of downloads, and analyses its differences and relations with other periodical evaluation indexes through the empirical analysis research on half-life period of downloads as to library &information science periodicals. The result shows that half-life period of journal downloads are much smaller than cited half-life period and citation half-life period, and there is significant correlation with the cited half-life period among them as well;but compared with other periodical evaluation indexes, there exist its own traits and independence; it avails for the research of half-life periodical downloads to break through barriers in the study of aging citation analysis, to improve the timeliness of periodical evaluation and expand the scope of inspection, and also to promote periodical publishing organizations to take the initiative shortening of the delay between online and print publication, which will have a positive impact on the promotion of overall journal influence.

  10. Fast renal trapping of porcine Luteinizing Hormone (pLH shown by 123I-scintigraphic imaging in rats explains its short circulatory half-life

    Directory of Open Access Journals (Sweden)

    Locatelli Alain

    2003-10-01

    Full Text Available Abstract Background Sugar moieties of gonadotropins play no primary role in receptor binding but they strongly affect their circulatory half-life and consequently their in vivo biopotencies. In order to relate more precisely hepatic trapping of these glycoproteic hormones with their circulatory half-life, we undertook a comparative study of the distribution and elimination of porcine LH (pLH and equine CG (eCG which exhibit respectively a short and a long half-life. This was done first by following half-lives of pLH in piglets with hepatic portal circulation shunted or not. It was expected that such a shunt would enhance the short half-life of pLH. Subsequently, scintigraphic imaging of both 123I-pLH and 123I-eCG was performed in intact rats to compare their routes and rates of distribution and elimination. Methods Native pLH or eCG was injected to normal piglets and pLH was tested in liver-shunted anæsthetized piglet. Blood samples were recovered sequentially over one hour time and the hormone concentrations were determined by a specific ELISA method. Scintigraphic imaging of 123I-pLH and 123I-eCG was performed in rats using a OPTI-CGR gamma camera. Results In liver-shunted piglets, the half-life of pLH was found to be as short as in intact piglets (5 min. In the rat, the half-life of pLH was also found to be very short (3–6 min and 123I-pLH was found to accumulate in high quantity in less than 10 min post injection at the level of kidneys but not in the liver. 123I-eCG didn't accumulate in any organ in the rats during the first hour, plasma concentrations of this gonadotropin being still elevated (80% at this time. Conclusion In both the porcine and rat species, the liver is not responsible for the rapid elimination of pLH from the circulation compared to eCG. Our scintigraphic experiments suggest that the very short circulatory half-life of LH is due to rapid renal trapping.

  11. Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting.

    Science.gov (United States)

    Meyer, Saskia; Nederend, Maaike; Jansen, J H Marco; Reiding, Karli R; Jacobino, Shamir R; Meeldijk, Jan; Bovenschen, Niels; Wuhrer, Manfred; Valerius, Thomas; Ubink, Ruud; Boross, Peter; Rouwendal, Gerard; Leusen, Jeanette H W

    2016-01-01

    Antibody therapy is a validated treatment approach for several malignancies. All currently clinically applied therapeutic antibodies (Abs) are of the IgG isotype. However, not all patients respond to this therapy and relapses can occur. IgA represents an alternative isotype for antibody therapy that engages FcαRI expressing myeloid effector cells, such as neutrophils and monocytes. IgA Abs have been shown to effectively kill tumor cells both in vitro and in vivo. However, due to the short half-life of IgA Abs in mice, daily injections are required to reach an effect comparable to IgG Abs. The relatively long half-life of IgG Abs and serum albumin arises from their capability of interacting with the neonatal Fc receptor (FcRn). As IgA Abs lack a binding site for FcRn, we generated IgA Abs with the variable regions of the Her2-specific Ab trastuzumab and attached an albumin-binding domain (ABD) to the heavy or light chain (HCABD/LCABD) to extend their serum half-life. These modified Abs were able to bind albumin from different species in vitro. Furthermore, tumor cell lysis of IgA-Her2-LCABD Abs in vitro was similar to unmodified IgA-Her2 Abs. Pharmacokinetic studies in mice revealed that the serum exposure and half-life of the modified IgA-Her2 Abs was extended. In a xenograft mouse model, the modified IgA1 Abs exhibited a slightly, but significantly, improved anti-tumor response compared to the unmodified Ab. In conclusion, empowering IgA Abs with albumin-binding capacity results in in vitro and in vivo functional Abs with an enhanced exposure and prolonged half-life.

  12. Existing Default Values and Recommendations for Exposure Assessment - A Nordic Exposure Group Project 2011

    OpenAIRE

    Höglund, Lena; Räisänen, Jouni; Hämäläinen, Anne-Maija; Warholm, Margareta; van der Hagen, Marianne; Suleiman, Abdulqadir; Kristjánsson, Víðir; Nielsen, Elsa; Kopp, Tine Iskov

    2012-01-01

    Default values are often used in exposure assessments e.g. in modelling because of lack of actually measured data. The quality of the exposure assessment outcome is therefore heavily dependent on the validity and representativeness this input data. Today the used default factors consist of a wide range of more or less well-documented values originating from many different sources. The purpose of this report is to give an overview and to evaluate exposure factors that are currently used by th...

  13. Refinements on the age-dependent half-life model for estimating child body burdens of polychlorodibenzodioxins and dibenzofurans.

    Science.gov (United States)

    Kerger, Brent D; Leung, Hon-Wing; Scott, Paul K; Paustenbach, Dennis J

    2007-04-01

    We modified our prior age-dependent half-life model to characterize the range of child (ages 0-7) body burdens associated with dietary and environmental exposure to polychlorodibenzodioxins and furans (PCDD/Fs). Several exposure scenarios were evaluated. Infants were assumed to be either breast-fed or formula-fed from birth to 6 months of age. They then received intakes of PCDD/Fs through age 7 from foods based on weighted means estimates [JECFA, 2001. Joint FAO/WHO Committee on Food Additives. Fifty-seventh meeting, Rome, June 5-14 , 2001, pp. 24-40], and with or without exposures (ingestion and dermal) to urban residential soils at 1ppb TCDD toxic equivalents (TEQ). A one-compartment (adipose volume) toxicokinetic model for TCDD described by Kreuzer [Kreuzer, P.F., Csanady, Gy.A., et al., 1997. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and congeners in infants. A toxicokinetic model of human lifetime body burden by TCDD with special emphasis on its uptake by nutrition. Arch. Toxicol. 71, 383-400] was expanded to include the key non-TCDD congeners in human breast milk and adipose tissues, and two model parameter refinements were examined: (1) use of updated and more detailed age-correlated body fat mass data [CDC, 2000. Centers for Disease Control. CDC Growth Charts: United States. Advance Data from Vital and Health Statistics of the Centers for Disease Control and Prevention, National Center for Health Statistics, Number 314, December 2000]; (2) use of breast milk PCDD/F concentration data from sampling completed in 2000-2003 [Wittsiepe, J., Fürst, P., et al., 2004. PCDD/F and dioxin-like PCB in human blood and milk from German mothers. Organohalogen Compd. 66, 2865-2872]. The updated body fat mass data nearly halved the predicted peak body burden for breast-feeding and lowered the time-weighted average (TWA) body burdens from ages 0-7 by 30-40% for breast-fed and formula-fed infants. Combined use of the updated breast milk PCDD/F concentration and body fat

  14. Existing Default Values and Recommendations for Exposure Assessment - A Nordic Exposure Group Project 2011

    DEFF Research Database (Denmark)

    Höglund, Lena; Räisänen, Jouni; Hämäläinen, Anne-Maija

    Default values are often used in exposure assessments e.g. in modelling because of lack of actually measured data. The quality of the exposure assessment outcome is therefore heavily dependent on the validity and representativeness this input data. Today the used default factors consist of a wide...

  15. Recommended Parameter Values for GENII Modeling of Radionuclides in Routine Air and Water Releases

    Energy Technology Data Exchange (ETDEWEB)

    Snyder, Sandra F.; Arimescu, Carmen; Napier, Bruce A.; Hay, Tristan R.

    2012-11-01

    The GENII v2 code is used to estimate dose to individuals or populations from the release of radioactive materials into air or water. Numerous parameter values are required for input into this code. User-defined parameters cover the spectrum from chemical data, meteorological data, agricultural data, and behavioral data. This document is a summary of parameter values that reflect conditions in the United States. Reasonable regional and age-dependent data is summarized. Data availability and quality varies. The set of parameters described address scenarios for chronic air emissions or chronic releases to public waterways. Considerations for the special tritium and carbon-14 models are briefly addressed. GENIIv2.10.0 is the current software version that this document supports.

  16. Biological half-life of radioactive cesium in Japanese rockfish Sebastes cheni contaminated by the Fukushima Daiichi nuclear power plant accident.

    Science.gov (United States)

    Matsumoto, Akira; Shigeoka, Yu; Arakawa, Hisayuki; Hirakawa, Naoto; Morioka, Yoshiaki; Mizuno, Takuji

    2015-12-01

    Since the Fukushima accident in March 2011 the concentration of radioactive cesium in Japanese rockfish (Sebastes cheni) has been decreasing slower than other fish species. The aim of this study was therefore to investigate the possibility of slow elimination rate (i.e., relatively longer Tb) as one of the reasons for the slow decrease in (137)Cs concentrations in Japanese rockfish (S. cheni). To do this, we reared twenty-three individuals of this species for a period of about 1 year, during which time we measured the (137)Cs concentrations and γ-ray spectra 14 times by using a high-efficiency NaI(Tl) scintillator. We then examined the relationship between the (137)Cs concentrations and the total length of each individual. We estimated the biological half-life (Tb, day) for each individual using the total number of (137)Cs counts in the energy region, and examined the effects of total length and (137)Cs concentration on Tb by generalized linear model (GLM). We also examined the effect of sex, total length, seawater temperature, and the (137)Cs concentration of seawater on temporal changes in the (137)Cs count reduction rate by GLM. There was no clear relationship between the corrected whole-body (137)Cs concentrations and the total length in females, however there was a significant positive correlation between these two variables in males. The difference between males and females may be attributable to variation in the degree of dilution because of variable growth of individuals, and suggests that the (137)Cs concentrations of small individuals may be greatly diluted because of faster growth. However, there was no significant difference in Tb between sexes. The mean Tb (±SD) in all individuals was 269 (±39) days; this Tb value is 2.7-5.4 times longer than past Tb values (marine fish: 50-100 days), and is thought to be one of the reasons for the slower decrease in (137)Cs concentrations in this species than other fish species on the coast of Fukushima. The GLM

  17. Measurement of the two-neutrino double-beta decay half-life of {sup 130}Te with the CUORE-0 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Alduino, C.; Avignone, F.T.; Chott, N.; Creswick, R.J.; Rosenfeld, C.; Wilson, J. [University of South Carolina, Department of Physics and Astronomy, Columbia, SC (United States); Alfonso, K.; Hickerson, K.P.; Huang, H.Z.; Liu, X.; Trentalange, S.; Zhu, B.X. [University of California, Department of Physics and Astronomy, Los Angeles, CA (United States); Artusa, D.R. [University of South Carolina, Department of Physics and Astronomy, Columbia, SC (United States); INFN-Laboratori Nazionali del Gran Sasso, Assergi, L' Aquila (Italy); Azzolini, O.; Camacho, A.; Keppel, G.; Palmieri, V.; Pira, C. [INFN-Laboratori Nazionali di Legnaro, Legnaro, Padova (Italy); Banks, T.I.; Drobizhev, A.; Freedman, S.J.; Hennings-Yeomans, R.; O' Donnell, T.; Wagaarachchi, S.L. [University of California, Department of Physics, Berkeley, CA (United States); Lawrence Berkeley National Laboratory, Nuclear Science Division, Berkeley, CA (United States); Bari, G.; Deninno, M.M. [INFN-Sezione di Bologna, Bologna (Italy); Beeman, J.W. [Lawrence Berkeley National Laboratory, Materials Science Division, Berkeley, CA (United States); Bellini, F.; Cardani, L.; Casali, N.; Cosmelli, C.; Ferroni, F. [Sapienza Universita di Roma, Dipartimento di Fisica, Rome (Italy); INFN-Sezione di Roma, Rome (Italy); Bersani, A.; Caminata, A. [INFN-Sezione di Genova, Genova (Italy); Biassoni, M.; Carbone, L.; Cremonesi, O.; Ferri, E.; Giachero, A.; Pessina, G.; Previtali, E.; Rusconi, C. [INFN-Sezione di Milano Bicocca, Milan (Italy); Brofferio, C.; Capelli, S.; Carniti, P.; Cassina, L.; Chiesa, D.; Clemenza, M.; Faverzani, M.; Fiorini, E.; Gironi, L.; Gotti, C.; Maino, M.; Nucciotti, A.; Pavan, M.; Pozzi, S.; Sisti, M.; Terranova, F.; Zanotti, L. [Universita di Milano-Bicocca, Dipartimento di Fisica, Milan (Italy); INFN-Sezione di Milano Bicocca, Milan (Italy); Bucci, C.; Cappelli, L.; D' Addabbo, A.; Di Vacri, M.L.; Gorla, P.; Pattavina, L.; Pirro, S. [INFN-Laboratori Nazionali del Gran Sasso, Assergi, L' Aquila (Italy); Canonica, L. [INFN-Laboratori Nazionali del Gran Sasso, Assergi, L' Aquila (Italy); Massachusetts Institute of Technology, Cambridge, MA (United States); Cao, X.G.; Fang, D.Q.; Ma, Y.G.; Wang, H.W.; Zhang, G.Q. [Chinese Academy of Sciences, Shanghai Institute of Applied Physics, Shanghai (China); Copello, S.; Di Domizio, S.; Fernandes, G.; Marini, L.; Pallavicini, M. [INFN-Sezione di Genova, Genova (Italy); Universita di Genova, Dipartimento di Fisica, Genova (Italy); Cushman, J.S.; Davis, C.J.; Heeger, K.M.; Lim, K.E.; Maruyama, R.H. [Yale University, Department of Physics, New Haven, CT (United States); Dafinei, I.; Morganti, S.; Mosteiro, P.J.; Orio, F.; Pettinacci, V.; Tomei, C.; Vignati, M. [INFN-Sezione di Roma, Rome (Italy); Dell' Oro, S. [INFN-Laboratori Nazionali del Gran Sasso, Assergi, L' Aquila (Italy); INFN-Gran Sasso Science Institute, L' Aquila (Italy); Feintzeig, J.; Fujikawa, B.K.; Mei, Y.; Smith, A.R. [Lawrence Berkeley National Laboratory, Nuclear Science Division, Berkeley, CA (United States); Franceschi, M.A.; Ligi, C.; Napolitano, T.; Piperno, G. [INFN-Laboratori Nazionali di Frascati, Frascati, Rome (Italy); Giuliani, A.; Tenconi, M. [Universite Paris-Saclay, CSNSM, Univ. Paris-Sud, CNRS/IN2P3, Orsay (France); Gladstone, L.; Leder, A.; Winslow, L.A. [Massachusetts Institute of Technology, Cambridge, MA (United States); Gutierrez, T.D. [California Polytechnic State University, Physics Department, San Luis Obispo, CA (United States); Haller, E.E. [Lawrence Berkeley National Laboratory, Materials Science Division, Berkeley, CA (United States); University of California, Department of Materials Science and Engineering, Berkeley, CA (United States); Han, K. [Yale University, Department of Physics, New Haven, CT (United States); Shanghai Jiao Tong University, Department of Physics and Astronomy, Shanghai (China); Hansen, E. [University of California, Department of Physics and Astronomy, Los Angeles, CA (United States); Massachusetts Institute of Technology, Cambridge, MA (United States); Kadel, R. [Lawrence Berkeley National Laboratory, Physics Division, Berkeley, CA (United States); Kolomensky, Yu.G. [University of California, Department of Physics, Berkeley, CA (United States); Lawrence Berkeley National Laboratory, Nuclear Science Division, Berkeley, CA (United States); Lawrence Berkeley National Laboratory, Physics Division, Berkeley, CA (United States); Martinez, M. [Sapienza Universita di Roma, Dipartimento di Fisica, Rome (Italy); INFN-Sezione di Roma, Rome (Italy); Universidad de Zaragoza, Laboratorio de Fisica Nuclear y Astroparticulas, Zaragoza (Spain); Moggi, N. [INFN-Sezione di Bologna, Bologna (Italy); Alma Mater Studiorum-Universita di Bologna, Dipartimento di Scienze per la Qualita della Vita, Bologna (Italy); Nones, C. [Service de Physique des Particules, CEA/Saclay, Gif-sur-Yvette (France); Norman, E.B.; Wang, B.S. [Lawrence Livermore National Laboratory, Livermore, CA (United States); University of California, Department of Nuclear Engineering, Berkeley, CA (United States); Ouellet, J.L. [University of California, Department of Physics, Berkeley, CA (United States); Lawrence Berkeley National Laboratory, Nuclear Science Division, Berkeley, CA (United States); Massachusetts Institute of Technology, Cambridge, MA (United States); Pagliarone, C.E. [INFN-Laboratori Nazionali del Gran Sasso, Assergi, L' Aquila (Italy); Universita degli Studi di Cassino e del Lazio Meridionale, Dipartimento di Ingegneria Civile e Meccanica, Cassino (Italy); Sangiorgio, S.; Scielzo, N.D. [Lawrence Livermore National Laboratory, Livermore, CA (United States); Santone, D. [INFN-Laboratori Nazionali del Gran Sasso, Assergi, L' Aquila (Italy); Universita dell' Aquila, Dipartimento di Scienze Fisiche e Chimiche, L' Aquila (Italy); Singh, V. [University of California, Department of Physics, Berkeley, CA (US); Taffarello, L. [INFN-Sezione di Padova, Padova (IT); Wise, T. [Yale University, Department of Physics, New Haven, CT (US); University of Wisconsin, Department of Physics, Madison, WI (US); Woodcraft, A. [University of Edinburgh, SUPA, Institute for Astronomy, Edinburgh (GB); Zimmermann, S. [Lawrence Berkeley National Laboratory, Engineering Division, Berkeley, CA (US); Zucchelli, S. [INFN-Sezione di Bologna, Bologna (IT); Alma Mater Studiorum-Universita di Bologna, Dipartimento di Fisica e Astronomia, Bologna (IT)

    2017-01-15

    We report on the measurement of the two-neutrino double-beta decay half-life of {sup 130}Te with the CUORE-0 detector. From an exposure of 33.4 kg year of TeO{sub 2}, the half-life is determined to be T{sub 1/2}{sup 2ν} = [8.2 ± 0.2 (stat.) ± 0.6 (syst.)] x 10{sup 20} year. This result is obtained after a detailed reconstruction of the sources responsible for the CUORE-0 counting rate, with a specific study of those contributing to the {sup 130}Te neutrinoless double-beta decay region of interest. (orig.)

  18. Measurement of the half-life of the two-neutrino double beta decay of Ge-76 with the Gerda experiment

    CERN Document Server

    Agostini, M; Andreotti, E; Bakalyarov, A M; Balata, M; Barabanov, I; Heider, M Barnabe; Barros, N; Baudis, L; Bauer, C; Becerici-Schmidt, N; Bellotti, E; Belogurov, S; Belyaev, S T; Benato, G; Bettini, A; Bezrukov, L; Bode, T; Brudanin, V; Brugnera, R; Budjas, D; Caldwell, A; Cattadori, C; Chernogorov, A; Cossavella, F; Demidova, E V; Denisov, A; Domula, A; Egorov, V; Falkenstein, R; Ferella, A D; Freund, K; Froborg, F; Frodyma, N; Gangapshev, A; Garfagnini, A; Gazzana, S; Grambayr, P; Gurentsov, V; Gusev, K; Guthikonda, K K; Hampel, W; Hegai, A; Heisel, M; Hemmer, S; Heusser, G; Hofmann, W; Hult, M; Inzhechik, L V; Ioannucci, L; Csathy, J Janicsko; Jochum, J; Junker, M; Kianovsky, S; Kirpichnikov, I V; Kirsch, A; Klimenko, A; Knoepfle, K T; Kochetov, O; Kornoukhov, V N; Kusminov, V; Laubenstein, M; Lazzaro, A; Lebedev, V I; Lehnert, B; Liao, H Y; Lindner, M; Lippi, I; Liu, X; Lubashevskiy, A; Lubsandorzhiev, B; Lutter, G; Machado, A A; Majorovits, B; Maneschg, W; Nemchenok, I; Nisi, S; O'Shaughnessy, C; Pandola, L; Pelczar, K; Peraro, L; Pullia, A; Riboldi, S; Ritter, F; Sada, C; Salathe, M; Schmitt, C; Schoenert, S; Schreiner, J; Schulz, O; Schwingenheuer, B; Shevchik, E; Shirchenko, M; Simgen, H; Smolnikov, A; Stanco, L; Strecker, H; Tarka, M; Ur, C A; Vasenko, A A; Volynets, O; von Sturm, K; Walter, M; Wegmann, A; Wojcik, M; Yanovich, E; Zavarise, P; Zhitnikov, I; Zhukov, S V; Zinatulina, D; Zuber, K; Zuzel, G

    2012-01-01

    The primary goal of the GERmanium Detector Array (Gerda) experiment at the Laboratori Nazionali del Gran Sasso of INFN is the search for the neutrinoless double beta decay of Ge-76. High-purity germanium detectors made from material enriched in Ge-76 are operated directly immersed in liquid argon, allowing for a substantial reduction of the background with respect to predecessor experiments. The first 5.04 kg yr of data collected in Phase I of the experiment have been analyzed to measure the half-life of the neutrino-accompanied double beta decay of Ge-76. The observed spectrum in the energy range between 600 and 1800 keV is dominated by the double beta decay of Ge-76. The half-life extracted from Gerda data is T(1/2) = (1.84 +0.14 -0.10) 10^{21} yr.

  19. Measurement of the two-neutrino double-beta decay half-life of $^{130}$ Te with the CUORE-0 experiment

    Energy Technology Data Exchange (ETDEWEB)

    Alduino, C.; Alfonso, K.; Artusa, D. R.; Avignone, F. T.; Azzolini, O.; Banks, T. I.; Bari, G.; Beeman, J. W.; Bellini, F.; Bersani, A.; Biassoni, M.; Brofferio, C.; Bucci, C.; Camacho, A.; Caminata, A.; Canonica, L.; Cao, X. G.; Capelli, S.; Cappelli, L.; Carbone, L.; Cardani, L.; Carniti, P.; Casali, N.; Cassina, L.; Chiesa, D.; Chott, N.; Clemenza, M.; Copello, S.; Cosmelli, C.; Cremonesi, O.; Creswick, R. J.; Cushman, J. S.; D’Addabbo, A.; Dafinei, I.; Davis, C. J.; Dell’Oro, S.; Deninno, M. M.; Di Domizio, S.; Di Vacri, M. L.; Drobizhev, A.; Fang, D. Q.; Faverzani, M.; Feintzeig, J.; Fernandes, G.; Ferri, E.; Ferroni, F.; Fiorini, E.; Franceschi, M. A.; Freedman, S. J.; Fujikawa, B. K.; Giachero, A.; Gironi, L.; Giuliani, A.; Gladstone, L.; Gorla, P.; Gotti, C.; Gutierrez, T. D.; Haller, E. E.; Han, K.; Hansen, E.; Heeger, K. M.; Hennings-Yeomans, R.; Hickerson, K. P.; Huang, H. Z.; Kadel, R.; Keppel, G.; Kolomensky, Yu. G.; Leder, A.; Ligi, C.; Lim, K. E.; Liu, X.; Ma, Y. G.; Maino, M.; Marini, L.; Martinez, M.; Maruyama, R. H.; Mei, Y.; Moggi, N.; Morganti, S.; Mosteiro, P. J.; Napolitano, T.; Nones, C.; Norman, E. B.; Nucciotti, A.; O’Donnell, T.; Orio, F.; Ouellet, J. L.; Pagliarone, C. E.; Pallavicini, M.; Palmieri, V.; Pattavina, L.; Pavan, M.; Pessina, G.; Pettinacci, V.; Piperno, G.; Pira, C.; Pirro, S.; Pozzi, S.; Previtali, E.; Rosenfeld, C.; Rusconi, C.; Sangiorgio, S.; Santone, D.; Scielzo, N. D.; Singh, V.; Sisti, M.; Smith, A. R.; Taffarello, L.; Tenconi, M.; Terranova, F.; Tomei, C.; Trentalange, S.; Vignati, M.; Wagaarachchi, S. L.; Wang, B. S.; Wang, H. W.; Wilson, J.; Winslow, L. A.; Wise, T.; Woodcraft, A.; Zanotti, L.; Zhang, G. Q.; Zhu, B. X.; Zimmermann, S.; Zucchelli, S.

    2017-01-01

    We report on the measurement of the two-neutrino double-beta decay half-life of 130 Te with the CUORE-0 detector. From an exposure of 33.4 kg year of TeO 22 , the half-life is determined to be T$2ν\\atop{1/2}$ = [8.2 ± 0.2 (stat.) ± 0.6 (syst.)] ×× 10 20 year. This result is obtained after a detailed reconstruction of the sources responsible for the CUORE-0 counting rate, with a specific study of those contributing to the 130130 Te neutrinoless double-beta decay region of interest.

  20. A novel exendin-4 human serum albumin fusion protein, E2HSA, with an extended half-life and good glucoregulatory effect in healthy rhesus monkeys

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Ling; Wang, Lin; Meng, Zhiyun; Gan, Hui; Gu, Ruolan; Wu, Zhuona; Gao, Lei; Zhu, Xiaoxia; Sun, Wenzhong; Li, Jian; Zheng, Ying; Dou, Guifang, E-mail: douguifang@vip.163.com

    2014-03-07

    Highlights: • E2HSA has an extended half-life and good plasma stability. • E2HSA could improve glucose-dependent insulin secretion. • E2HSA has excellent glucoregulatory effects in vivo. • E2HSA could potentially be used as a new long-acting GLP-1 receptor agonist for type 2 diabetes management. - Abstract: Glucagon-like peptide-1 (GLP-1) has attracted considerable research interest in terms of the treatment of type 2 diabetes due to their multiple glucoregulatory functions. However, the short half-life, rapid inactivation by dipeptidyl peptidase-IV (DPP-IV) and excretion, limits the therapeutic potential of the native incretin hormone. Therefore, efforts are being made to develop the long-acting incretin mimetics via modifying its structure. Here we report a novel recombinant exendin-4 human serum albumin fusion protein E2HSA with HSA molecule extends their circulatory half-life in vivo while still retaining exendin-4 biological activity and therapeutic properties. In vitro comparisons of E2HSA and exendin-4 showed similar insulinotropic activity on rat pancreatic islets and GLP-1R-dependent biological activity on RIN-m5F cells, although E2HSA was less potent than exendin-4. E2HSA had a terminal elimation half-life of approximate 54 h in healthy rhesus monkeys. Furthermore, E2HSA could reduce postprandial glucose excursion and control fasting glucose level, dose-dependent suppress food intake. Improvement in glucose-dependent insulin secretion and control serum glucose excursions were observed during hyperglycemic clamp test (18 h) and oral glucose tolerance test (42 h) respectively. Thus the improved physiological characterization of E2HSA make it a new potent anti-diabetic drug for type 2 diabetes therapy.

  1. Nicotinic stimulation modulates tyrosine hydroxylase mRNA half-life and protein binding to the 3'UTR in a manner that requires transcription.

    Science.gov (United States)

    Roe, David F; Craviso, Gale L; Waymire, Jack C

    2004-01-05

    Tyrosine hydroxylase (TH) expression increases in adrenal chromaffin cells treated with the nicotinic agonist, dimethylphenylpiperazinium (DMPP; 1 microM). We are using this response as a model of the changes in TH level that occur during increased cholinergic neural activity. Here we report a 4-fold increase in TH mRNA half-life in DMPP-treated cells chromaffin cells that is apparent when using a pulse-chase analysis to measure TH mRNA half-life. No increase is apparent using actinomycin D to measure half-life, indicating a requirement for ongoing transcription. Characterization of protein binding to the TH 3'UTR responsible for stabilization using labeled TH 3'UTR probes and electro-mobility shift assays shows the presence of two complexes both of which are increased by DMPP-treatment. The faster migrating complex (FMC) increases 2.5-fold and the slower migrating complex (SMC) increases 1.5-fold. Both changes are prevented by actinomycin D. Characterization of the protein binding to the TH UTR probes indicates SMC is disrupted by polyribonucleotides, poly (A) and poly (U), while binding to FMC is reduced by poly (CU). Separation of UV crosslinked RNA-protein complexes on SDS polyacrylamide gels shows FMC to contain a single protein whereas SMC contains three proteins. Northwesterns yielded similar results. Comparison of DMPP-induced protein binding with the poly C binding protein (PCBP) involved in hypoxia induced rat PC12 TH mRNA stability indicates none of the bovine UTR binding proteins are the PCBP. Thus, nicotinic stimulation produces a transcription-dependent increase in TH mRNA half-life that is mediated by previously unrecognized TH mRNA binding proteins.

  2. The New SI and the CODATA recommended values of the fundamental constants 2014 (arXiv:1507.07956)

    CERN Document Server

    Pavese, Franco

    2015-01-01

    This note's aim is to point out some standing features of the present CODATA method in the light of the recent CODATA table of the 2014 recommended values for the fundamental constants published on paper arXiv:1507.07956. A comprehensive discussion on this and related issues is becoming very important in view of the foreseen revision of the SI, presently planned for 2018. These features may raise doubts on a possible mixing of physical reasons of general validity in science with some needs specific of metrology concerning the base units of the International System (SI) of measurement units.

  3. Recommendations for the measurement of FIV(1) values in chronic obstructive pulmonary disease.

    Science.gov (United States)

    Visser, Frank J; Ramlal, Sunil; Dekhuijzen, P N Richard; Heijdra, Yvonne F

    2008-01-01

    In contrast to static inspiratory parameters such as vital capacity and inspiratory capacity, information on forced inspiratory volume in 1 s (FIV(1)) in patients with chronic obstructive pulmonary disease (COPD) is limited. It was the aim of this study to investigate the influence of the preceding expiratory manoeuvre and the optimal number of manoeuvres on FIV(1) values. In 169 patients with COPD, FIV(1) manoeuvres were performed after a forced (FIV(1)-Fe) and a slow (FIV(1)-Se) expiration. To investigate the optimal number of the FIV(1)-Se manoeuvres, 8 attempts were performed. The variability of FIV(1)-Fe was greater than that of FIV(1)-Se. The mean difference between FIV(1)-Se and FIV(1)-Fe was 0.21 litres (p Obstructive Lung Disease (GOLD) stage. The higher the GOLD stage, the greater the difference between the 2 techniques. The correlation coefficient between FIV(1)-Se and FIV(1)-Fe was high (r = 0.89, p = 0.01), but there was a poor agreement between these parameters (limits of agreement -0.52 to 0.94 litres). Five manoeuvres were needed to obtain an optimal FIV(1)-Se. There was no association with the GOLD stage. In COPD patients, FIV(1)-Se are less variable than FIV(1)-Fe, the agreement between the 2 manoeuvres is poor, and at least 5 FIV(1)-Se manoeuvres are needed to get an acceptable FIV(1). This holds for all GOLD stages. 2007 S. Karger AG, Basel.

  4. Pile-up corrections for high-precision superallowed {beta} decay half-life measurements via {gamma}-ray photopeak counting

    Energy Technology Data Exchange (ETDEWEB)

    Grinyer, G.F. [Department of Physics, University of Guelph, Guelph, Ont, N1G 2W1 (Canada)], E-mail: ggrinyer@physics.uoguelph.ca; Svensson, C.E.; Andreoiu, C. [Department of Physics, University of Guelph, Guelph, Ont, N1G 2W1 (Canada); Andreyev, A.N. [TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, V6T 2A3 (Canada); Austin, R.A.E. [Department of Astronomy and Physics, St. Mary' s University, Halifax, NS, B3H 3C3 (Canada); Ball, G.C. [TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, V6T 2A3 (Canada); Bandyopadhyay, D. [Department of Physics, University of Guelph, Guelph, Ont, N1G 2W1 (Canada); Chakrawarthy, R.S. [TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, V6T 2A3 (Canada); Finlay, P. [Department of Physics, University of Guelph, Guelph, Ont, N1G 2W1 (Canada); Garrett, P.E. [Department of Physics, University of Guelph, Guelph, Ont, Canada N1G 2W1 (Canada); TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, V6T 2A3 (Canada); Hackman, G. [TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, V6T 2A3 (Canada); Hyland, B. [Department of Physics, University of Guelph, Guelph, Ont, N1G 2W1 (Canada); Kulp, W.D. [School of Physics, Georgia Institute of Technology, Atlanta, GA 30332 0430 (United States); Leach, K.G. [Department of Physics, University of Guelph, Guelph, Ont, N1G 2W1 (Canada); Leslie, J.R. [Department of Physics, Queen' s University, Kingston, Ont., K7L 3N6 (Canada); Morton, A.C.; Pearson, C.J. [TRIUMF, 4004 Wesbrook Mall, Vancouver, BC, V6T 2A3 (Canada); Phillips, A.A. [Department of Physics, University of Guelph, Guelph, Ont, N1G 2W1 (Canada); Sarazin, F. [Department of Physics, Colorado School of Mines, Golden, CO 80401 (United States); Schumaker, M.A. [Department of Physics, University of Guelph, Guelph, Ont, N1G 2W1 (Canada)] (and others)

    2007-09-11

    A general technique that corrects {gamma}-ray gated {beta} decay-curve data for detector pulse pile-up is presented. The method includes corrections for non-zero time-resolution and energy-threshold effects in addition to a special treatment of saturating events due to cosmic rays. This technique is verified through a Monte Carlo simulation and experimental data using radioactive beams of {sup 26}Na implanted at the center of the 8{pi}{gamma}-ray spectrometer at the ISAC facility at TRIUMF in Vancouver, Canada. The {beta}-decay half-life of {sup 26}Na obtained from counting 1809-keV {gamma}-ray photopeaks emitted by the daughter {sup 26}Mg was determined to be T{sub 1/2}=1.07167{+-}0.00055s following a 27{sigma} correction for detector pulse pile-up. This result is in excellent agreement with the result of a previous measurement that employed direct {beta} counting and demonstrates the feasibility of high-precision {beta}-decay half-life measurements through the use of high-purity germanium {gamma}-ray detectors. The technique presented here, while motivated by superallowed-Fermi {beta} decay studies, is general and can be used for all half-life determinations (e.g. {alpha}-, {beta}-, X-ray, fission) in which a {gamma}-ray photopeak is used to select the decays of a particular isotope.

  5. Recommendations on adopting the values and correlations for calculating the thermophysical and kinetic properties of liquid lead

    Science.gov (United States)

    Savchenko, I. V.; Lezhnin, S. I.; Mosunova, N. A.

    2015-06-01

    Recent years have seen an essentially increased interest in studying the properties of liquid lead, which is primarily connected with the possibility of using it as coolant in nuclear power installations, first of all, in reactors based on fission of heavy nuclei by fast neutrons. The article presents an analysis of published data on the thermophysical and kinetic properties of lead in liquid state, the results of which served as a basis for selecting and recommending correlations to be used in carrying out scientific and engineering calculations. A general assessment of the state of experimental investigations into the thermophysical properties of liquid lead is presented. The presented value of lead solidification temperature is the maximally reliable one. The data on the boiling temperature, melting and vaporization enthalpies, and saturated vapor pressure have been determined with satisfactory accuracy. The published data on the liquid lead heat capacity differ considerably from each other; therefore, the recommended values should be experimentally checked and determined more exactly. The available experimental data on surface tension density, volumetric expansion coefficient, sound velocity, viscosity, and thermal conductivity do not cover the entire range of liquid phase existence temperatures. The temperature region above 1200 K and the crystal-liquid phase transition region are the least studied ones. Additional investigations of these properties in the above-mentioned temperature intervals are necessary. The question about the influence of impurities on the thermophysical properties of lead still remains to be answered and requires experimental investigations.

  6. Sailing From the Seas of Chaos Into the Corridor of Stability: Practical Recommendations to Increase the Informational Value of Studies.

    Science.gov (United States)

    Lakens, Daniël; Evers, Ellen R K

    2014-05-01

    Recent events have led psychologists to acknowledge that the inherent uncertainty encapsulated in an inductive science is amplified by problematic research practices. In this article, we provide a practical introduction to recently developed statistical tools that can be used to deal with these uncertainties when performing and evaluating research. In Part 1, we discuss the importance of accurate and stable effect size estimates as well as how to design studies to reach a corridor of stability around effect size estimates. In Part 2, we explain how, given uncertain effect size estimates, well-powered studies can be designed with sequential analyses. In Part 3, we (a) explain what p values convey about the likelihood that an effect is true, (b) illustrate how the v statistic can be used to evaluate the accuracy of individual studies, and (c) show how the evidential value of multiple studies can be examined with a p-curve analysis. We end by discussing the consequences of incorporating our recommendations in terms of a reduced quantity, but increased quality, of the research output. We hope that the practical recommendations discussed in this article will provide researchers with the tools to make important steps toward a psychological science that allows researchers to differentiate among all possible truths on the basis of their likelihood.

  7. Comparison of herbage yield, nutritive value and ensilability traits of three ryegrass species evaluated for the Irish Recommended List

    Directory of Open Access Journals (Sweden)

    Burns G. A.

    2015-06-01

    Full Text Available This study examined 169 of the newest varieties of three ryegrass species, perennial (Lolium perenne L., Italian (Lolium multiflorum Lam. and hybrid (Lolium boucheanum Kunth, from Recommended List trials in Ireland. The traits examined were yield, dry matter concentration, three nutritive value traits (in vitro dry matter digestibility, water-soluble carbohydrate on a dry matter basis and crude protein concentration and two ensilability traits (buffering capacity and water soluble carbohydrate concentration on an aqueous phase basis. Varietal monocultures of each species underwent a six cut combined simulated grazing and silage management in each of two years following sowing. Perennial ryegrass yielded less than both other species in one-year-old swards, but less than only Italian ryegrass in two-year-old swards, but generally had the higher in vitro dry matter digestibility and crude protein values. Italian ryegrass displayed the most favourable ensilability characteristics of the three species with perennial ryegrass less favourable and hybrid ryegrass intermediate. Overall, despite the high yields and favourable nutritive value and ensilability traits recorded, the general differences between the three ryegrass species studied were in line with industry expectations. These findings justify assessing the nutritive value and ensilability of ryegrass species, in addition to yield, to allow farmers select species that match farming enterprise requirements.

  8. Recommendations from the European Working Group for Value Assessment and Funding Processes in Rare Diseases (ORPH-VAL).

    Science.gov (United States)

    Annemans, Lieven; Aymé, Ségolène; Le Cam, Yann; Facey, Karen; Gunther, Penilla; Nicod, Elena; Reni, Michele; Roux, Jean-Louis; Schlander, Michael; Taylor, David; Tomino, Carlo; Torrent-Farnell, Josep; Upadhyaya, Sheela; Hutchings, Adam; Le Dez, Lugdivine

    2017-03-10

    Rare diseases are an important public health issue with high unmet need. The introduction of the EU Regulation on orphan medicinal products (OMP) has been successful in stimulating investment in the research and development of OMPs. Despite this advancement, patients do not have universal access to these new medicines. There are many factors that affect OMP uptake, but one of the most important is the difficulty of making pricing and reimbursement (P&R) decisions in rare diseases. Until now, there has been little consensus on the most appropriate assessment criteria, perspective or appraisal process. This paper proposes nine principles to help improve the consistency of OMP P&R assessment in Europe and ensure that value assessment, pricing and funding processes reflect the specificities of rare diseases and contribute to both the sustainability of healthcare systems and the sustainability of innovation in this field. These recommendations are the output of the European Working Group for Value Assessment and Funding Processes in Rare Diseases (ORPH-VAL), a collaboration between rare disease experts, patient representatives, academics, health technology assessment (HTA) practitioners, politicians and industry representatives. ORPH-VAL reached its recommendations through careful consideration of existing OMP P&R literature and through a wide consultation with expert stakeholders, including payers, regulators and patients. The principles cover four areas: OMP decision criteria, OMP decision process, OMP sustainable funding systems and European co-ordination. This paper also presents a guide to the core elements of value relevant to OMPs that should be consistently considered in all OMP appraisals. The principles outlined in this paper may be helpful in drawing together an emerging consensus on this topic and identifying areas where consistency in payer approach could be achievable and beneficial. All stakeholders have an obligation to work together to ensure

  9. Developing clinical practice guidelines: types of evidence and outcomes; values and economics, synthesis, grading, and presentation and deriving recommendations.

    Science.gov (United States)

    Woolf, Steven; Schünemann, Holger J; Eccles, Martin P; Grimshaw, Jeremy M; Shekelle, Paul

    2012-07-04

    Clinical practice guidelines are one of the foundations of efforts to improve healthcare. In 1999, we authored a paper about methods to develop guidelines. Since it was published, the methods of guideline development have progressed both in terms of methods and necessary procedures and the context for guideline development has changed with the emergence of guideline clearinghouses and large scale guideline production organisations (such as the UK National Institute for Health and Clinical Excellence). It therefore seems timely to, in a series of three articles, update and extend our earlier paper. In this second paper, we discuss issues of identifying and synthesizing evidence: deciding what type of evidence and outcomes to include in guidelines; integrating values into a guideline; incorporating economic considerations; synthesis, grading, and presentation of evidence; and moving from evidence to recommendations.

  10. Clinical utility and patient perspectives on the use of extended half-life rFIXFc in the management of hemophilia B

    Directory of Open Access Journals (Sweden)

    Miguelino MG

    2014-08-01

    Full Text Available Maricel G Miguelino, Jerry S Powell Division of Hematology and Oncology, University of California Davis Medical Center, Sacramento, CA, USA Abstract: Hemophilia B is an X-linked genetic disease caused by mutation of the gene for coagulation protein factor IX (FIX, with an incidence of approximately once every 30,000 male births in all populations and ethnic groups. When severe, the disease leads to spontaneous life threatening bleeding episodes. When untreated, most patients die from bleeding complications before 25 years of age. Current therapy requires frequent intravenous infusions of therapeutic recombinant or plasma-derived protein concentrates containing FIX. Most patients administer the infusions at home every few days, and must limit their physical activities to avoid abnormal bleeding when the FIX activity levels are below normal. After completing the pivotal Phase III clinical trial, a new therapeutic FIX preparation that has been engineered for an extended half-life in circulation, received regulatory approval in March 2014 in Canada and the US. This new FIX represents a major therapeutic advance for patients with hemophilia B. The half-life is prolonged due to fusion of the native FIX molecule with the normal constant region of immunoglobulin G. This fusion molecule then follows the normal immunoglobulin recirculation pathways through endothelial cells, resulting in prolonged times in circulation. In the clinical trials, over 150 patients successfully used eftrenonacog alfa regularly for more than 1 year to prevent spontaneous bleeding, to successfully treat any bleeding episodes, and to provide effective coagulation for major surgery. All infusions were well tolerated and effective, with no inhibitors detected and no safety concerns. This promising therapy should allow patients to use fewer infusions to maintain appropriate FIX activity levels in all clinical settings. Keywords: factor IX, hemophilia B, prophylaxis, genetic

  11. Measurement of the Double-Beta Decay Half-Life and Search for the Neutrinoless Double-Beta Decay of $^{48}{\\rm Ca}$ with the NEMO-3 Detector

    CERN Document Server

    :,; Augier, C; Bakalyarov, A M; Baker, J D; Barabash, A S; Basharina-Freshville, A; Blondel, S; Blot, S; Bongrand, M; Brudanin, V; Busto, J; Caffrey, A J; Calvez, S; Cascella, M; Cerna, C; Cesar, J P; Chapon, A; Chauveau, E; Chopra, A; Duchesneau, D; Durand, D; Egorov, V; Eurin, G; Evans, J J; Fajt, L; Filosofov, D; Flack, R; Garrido, X; Gómez, H; Guillon, B; Guzowski, P; Hodák, R; Huber, A; Hubert, P; Hugon, C; Jullian, S; Klimenko, A; Kochetov, O; Konovalov, S I; Kovalenko, V; Lalanne, D; Lang, K; Lebedev, V I; Lemière, Y; Noblet, T Le; Liptak, Z; Liu, X R; Loaiza, P; Lutter, G; Mamedov, F; Marquet, C; Mauger, F; Morgan, B; Mott, J; Nemchenok, I; Nomachi, M; Nova, F; Nowacki, F; Ohsumi, H; Pahlka, R B; Perrot, F; Piquemal, F; Povinec, P; Přidal, P; Ramachers, Y A; Remoto, A; Reyss, J L; Richards, B; Riddle, C L; Rukhadze, E; Rukhadze, N I; Saakyan, R; Salazar, R; Sarazin, X; Shitov, Yu; Simard, L; Šimkovic, F; Smetana, A; Smolek, K; Smolnikov, A; Söldner-Rembold, S; Soulé, B; Štekl, I; Suhonen, J; Sutton, C S; Szklarz, G; Thomas, J; Timkin, V; Torre, S; Tretyak, Vl I; Tretyak, V I; Umatov, V I; Vanushin, I; Vilela, C; Vorobel, V; Waters, D; Zhukov, S V; Žukauskas, A

    2016-01-01

    The NEMO-3 experiment at the Modane Underground Laboratory has investigated the double-$\\beta$ decay of $^{48}{\\rm Ca}$. Using $5.25$\\,yr of data recorded with a $6.99\\,{\\rm g}$ sample of $^{48}{\\rm Ca}$, approximately $150$ double-$\\beta$ decay candidate events have been selected with a signal-to-background ratio greater than $3$. The half-life for the two-neutrino double-$\\beta$ decay of $^{48}{\\rm Ca}$ has been measured to be \\mbox{$T^{2\

  12. An Integrated Approach to Moral, Value, and Civic Education with Adolescents: An Analysis of Current Theory and Practice and Recommendations for Program Implementation.

    Science.gov (United States)

    Lickona, Thomas

    Six value education methodologies for use on the secondary level are described and recommendations for implementing values/moral/civic education are presented. The first and second sections describe Lawrence Kohlberg's six-stage moral development approach to value education. The use of moral dilemma discussions to develop moral reasoning is…

  13. In silico prediction of brain exposure: drug free fraction, unbound brain to plasma concentration ratio and equilibrium half-life

    Science.gov (United States)

    Spreafico, Morena; Jacobson, Matthew P.

    2014-01-01

    The focus of CNS drug pharmacokinetics programs has recently shifted from determining the total concentrations in brain and blood to considering also unbound fractions and concentrations. Unfortunately, assessing unbound brain exposure experimentally requires demanding in vivo and in vitro studies. We propose a physical model, based on lipid binding and pH partitioning, to predict in silico the unbound volume of distribution in the brain. The model takes into account the partition of a drug into lipids, interstitial fluid and intracellular compartments of the brain. The results are in good agreement with the experimental data, suggesting that the contributions of lipid binding and pH partitioning are important in determining drug exposure in brain. The predicted values are used, together with predictions for plasma protein binding, as corrective terms in a second model to derive the unbound brain to plasma concentration ratio starting from experimental values of total concentration ratio. The calculated values of brain free fraction and passive permeability are also used to qualitatively determine the brain to plasma equilibration time in a model that shows promising results but is limited to a very small set of compounds. The models we propose are a step forward in understanding and predicting pharmacologically relevant exposure in brain starting from compounds’ chemical structure and neuropharmacokinetics, by using experimental total brain to plasma ratios, in silico calculated properties and simple physics-based approaches. The models can be used in central nervous system drug discovery programs for a fast and cheap assessment of unbound brain exposure. For existing compounds, the unbound ratios can be derived from experimental values of total brain to plasma ratios. For both existing and hypothetical compounds, the unbound volume of distribution due to lipid binding and pH partitioning can be calculated starting only from the chemical structure. PMID:23578025

  14. 裂变产物94Y和95Y半衰期的测定%Half-life determination of fission products 94Y and95Y

    Institute of Scientific and Technical Information of China (English)

    王世联; 白涛; 师全林; 张小林; 凡金龙; 李奇; 刘杰; 卢嘉春; 常永福

    2009-01-01

    用脉冲反应堆热中子辐照浓缩235U溶液靶,经快速放射化学分离纯化出94Y和95Y溶液,稀释并制备放射性浓度依次相差~10倍的3个测量源.将测量源放置在井式HPGe探测器井内,采用质量归一法测得94Y和95Y的半衰期分别为(19.16±0.05)min和(10.36±0.03)min.%Solutions of enriched235U were irradiated in thermal-neutron flux producedby apulsed reactor,and 94Yand 95Y werc separated chemically from the fission products immediately.The purified solution of 94Y and 95Y is diluted aboutten timgs in sequence to three concentration solutions.Three Sources were prepared with the solutions.The sources are measured,from the lower concentration to higher onc,with a well-type HPGe detector to determine the half-life of94Y and95Y.The determined half-life results arg(19.16±0.05)min and(10.35±0.04)min for94Y and 95Y respectively.

  15. Differential regulation of p21 (waf1) protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications.

    Science.gov (United States)

    Chang, Li-Ju; Eastman, Alan

    2012-09-01

    DNA damage induces the canonical p53 pathway including elevation of p21 (waf1) resulting in arrest of cell cycle progression. This can protect cells from subsequent Chk1 inhibition. Some p53 wild-type cancer cells such as HCT116 and U2OS exhibit attenuated p21 (waf1) induction upon DNA damage due to translational inhibition, and are incapable of maintaining arrest upon Chk1 inhibition. The purpose of this study was to determine whether this attenuated p21 (waf1) induction also occurred with the non-DNA damaging agent Nutlin-3 which induces p53 by disrupting binding to its negative regulator MDM2. We find that Nutlin-3 circumvented the attenuated induction of p21 (waf1) protein by increasing its half-life which led to G 1 and G 2 arrest in both cell lines. Interestingly, the p21 (waf1) protein half-life remained short on Nutlin-3 in p53 wild-type MCF10A cells; these cells achieve high p21 (waf1) levels through transcriptional upregulation. Consequently, all three p53 wild-type cells but not p53 mutant MDA-MB-231 cancer cells were protected from subsequent incubation with a combination of DNA damage plus a checkpoint inhibitor.

  16. Esculetin Downregulates the Expression of AML1-ETO and C-Kit in Kasumi-1 Cell Line by Decreasing Half-Life of mRNA.

    Science.gov (United States)

    Sawney, Sharad; Arora, Rashi; Aggarwal, Kamal K; Saluja, Daman

    2015-01-01

    One of the most frequent genetic aberrations in acute myeloid leukemia (AML) is chromosomal translocation between AML1/RUNX1 on chromosome 21 and ETO gene on chromosome 8 resulting in the expression of chimeric oncogene AML1-ETO. Although patients with t(8;21) translocation have good prognosis, 5-year survival is observed only in 50% of the cases. AML1-ETO translocation is usually accompanied by overexpression of mutant C-Kit, a tyrosine kinase, which contributes to uncontrolled proliferation of premature blood cells leading to relapse and poor prognosis. We illustrate the potential use of esculetin on leukemic cell line, Kasumi-1, bearing t(8;21) translocation and mutated C-Kit gene. Esculetin decreases the expression of AML1-ETO at both protein and transcript level within 24 hours of treatment. Half-life of AML1-ETO mRNA was reduced from 7 hours to 1.5 hours. Similarly half-life of C-Kit mRNA was reduced to 2 hours from 5 hours in esculetin treated cells. Esculetin also perturbed the expression of ectopically expressed AML1-ETO in U937 cells. The decreased expression of AML1-ETO chimeric gene was associated with increased expression of LAT1 and RUNX3 genes, targets of AML1. We envisage that discovery of a drug candidate which could target both these mutated genes would be a considerable breakthrough for future application.

  17. Esculetin Downregulates the Expression of AML1-ETO and C-Kit in Kasumi-1 Cell Line by Decreasing Half-Life of mRNA

    Directory of Open Access Journals (Sweden)

    Sharad Sawney

    2015-01-01

    Full Text Available One of the most frequent genetic aberrations in acute myeloid leukemia (AML is chromosomal translocation between AML1/RUNX1 on chromosome 21 and ETO gene on chromosome 8 resulting in the expression of chimeric oncogene AML1-ETO. Although patients with t(8;21 translocation have good prognosis, 5-year survival is observed only in 50% of the cases. AML1-ETO translocation is usually accompanied by overexpression of mutant C-Kit, a tyrosine kinase, which contributes to uncontrolled proliferation of premature blood cells leading to relapse and poor prognosis. We illustrate the potential use of esculetin on leukemic cell line, Kasumi-1, bearing t(8;21 translocation and mutated C-Kit gene. Esculetin decreases the expression of AML1-ETO at both protein and transcript level within 24 hours of treatment. Half-life of AML1-ETO mRNA was reduced from 7 hours to 1.5 hours. Similarly half-life of C-Kit mRNA was reduced to 2 hours from 5 hours in esculetin treated cells. Esculetin also perturbed the expression of ectopically expressed AML1-ETO in U937 cells. The decreased expression of AML1-ETO chimeric gene was associated with increased expression of LAT1 and RUNX3 genes, targets of AML1. We envisage that discovery of a drug candidate which could target both these mutated genes would be a considerable breakthrough for future application.

  18. New AMS method to measure the atom ratio {sup 146}Sm/{sup 147}Sm for a half-life determination of {sup 146}Sm

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, N. [Tandem Accelerator Complex, Research Facility Center for Science and Technology, University of Tsukuba (Japan); Paul, M., E-mail: paul@vms.huji.ac.il [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel); Alcorta, M. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Bowers, M.; Collon, P. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556-5670 (United States); Deibel, C.M. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Joint Institute for Nuclear Astrophysics, Michigan State University, East Lansing, MI 46624 (United States); DiGiovine, B. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Goriely, S. [Universite Libre de Bruxelles, CP-226, Brussels 1050 (Belgium); Greene, J.P.; Henderson, D.J.; Jiang, C.L. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Kashiv, Y. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556-5670 (United States); Kay, B.P.; Lee, H.Y.; Marley, S.T. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Nakanishi, T. [Faculty of Chemistry, Institute of Science and Engineering, Kanazawa University (Japan); Pardo, R.C.; Patel, N.; Rehm, K.E. [Physics Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Robertson, D. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556-5670 (United States); and others

    2013-01-15

    The extinct p-process nuclide {sup 146}Sm (t{sub 1/2} = 103 {+-} 5 Myr) is known to have been present in the Early-Solar System and has been proposed as an astrophysical chronometer. {sup 146}Sm is also intensely used to date meteorite and planetary differentiation processes, enhancing the importance of an accurate knowledge of the {sup 146}Sm half-life. We are engaged in a new determination of the {sup 146}Sm half-life in which the {sup 146}Sm/{sup 147}Sm atom ratio is determined by accelerator mass spectrometry at the ATLAS facility of Argonne National Laboratory. In order to reduce systematic errors in the AMS determination of the {sup 146}Sm/{sup 147}Sm ratios (in the range of 10{sup -7}-10{sup -9}), {sup 146}Sm and {sup 147}Sm ions were alternately counted in the same detector in the focal plane of a gas-filled magnet, respectively in continuous-wave and attenuated mode. Quantitative attenuation is obtained with the 12 MHz pulsed and ns-bunched ATLAS beam by chopping beam pulses with an RF sweeper in a ratio (digitally determined) down to 1:10{sup 6}. The experiments and preliminary results are discussed.

  19. Valuing the scholarship of integration and the scholarship of application in the academy for health sciences scholars: recommended methods

    Directory of Open Access Journals (Sweden)

    Newton Mandi

    2007-05-01

    Full Text Available Abstract In the landmark 1990 publication Scholarship Reconsidered, Boyer challenged the 'teaching verses research debates' by advocating for the scholarship of discovery, teaching, integration, and application. The scholarship of discovery considers publications and research as the yardstick in the merit, promotion and tenure system the world over. But this narrow view of scholarship does not fully support the obligations of universities to serve global societies and to improve health and health equity. Mechanisms to report the scholarship of teaching have been developed and adopted by some universities. In this article, we contribute to the less developed areas of scholarship, i.e. integration and application. We firstly situate the scholarship of discovery, teaching, integration and application within the interprofessional and knowledge exchange debates. Second, we propose a means for health science scholars to report the process and outcomes of the scholarship of integration and application with other disciplines, decision-makers and communities. We conclude with recommendations for structural and process change in faculty merit, tenure, and promotion systems so that health science scholars with varied academic portfolios are valued and many forms of academic scholarship are sustained. It is vital academic institutions remain relevant in an era when the production of knowledge is increasingly recognized as a social collaborative activity.

  20. Valuing the scholarship of integration and the scholarship of application in the academy for health sciences scholars: recommended methods.

    Science.gov (United States)

    Hofmeyer, Anne; Newton, Mandi; Scott, Cathie

    2007-05-29

    In the landmark 1990 publication Scholarship Reconsidered, Boyer challenged the 'teaching verses research debates' by advocating for the scholarship of discovery, teaching, integration, and application. The scholarship of discovery considers publications and research as the yardstick in the merit, promotion and tenure system the world over. But this narrow view of scholarship does not fully support the obligations of universities to serve global societies and to improve health and health equity. Mechanisms to report the scholarship of teaching have been developed and adopted by some universities. In this article, we contribute to the less developed areas of scholarship, i.e. integration and application. We firstly situate the scholarship of discovery, teaching, integration and application within the interprofessional and knowledge exchange debates. Second, we propose a means for health science scholars to report the process and outcomes of the scholarship of integration and application with other disciplines, decision-makers and communities. We conclude with recommendations for structural and process change in faculty merit, tenure, and promotion systems so that health science scholars with varied academic portfolios are valued and many forms of academic scholarship are sustained. It is vital academic institutions remain relevant in an era when the production of knowledge is increasingly recognized as a social collaborative activity.

  1. THE FIRST ISOLATION OF AMERICIUM IN THE FORM OF PURE COMPOUNDS - THE SPECIFIC ALPHA-ACTIVITY AND HALF-LIFE OF Am241

    Energy Technology Data Exchange (ETDEWEB)

    Cunningham, B.B.; Asprey, L.B.

    1950-07-20

    The microgram scale isolation and preparation of pure compounds of americium is described. Data are presented to show that the alpha-half-life of the isotope Am{sup 241} is 490 {+-} 14 years. The absorption spectrum of Am(III) in 1M nitric acid in the range 3500-8000 mu is given. The wave lengths of 10 of the most prominent lines in the copper spark emission spectrum of americium are given to the nearest 0.01 {angstrom}. Evidence is presented to show that the potential for the Am(III)-Am(IV) couple in acid solution is more negative than -2v and that the potential for the Am(II)-Am(III) couple is more positive than +0.9v.

  2. The effective and environmental half-life of {sup 137}Cs at Coral Islands at the former US nuclear test site

    Energy Technology Data Exchange (ETDEWEB)

    Robison, William L. E-mail: robison1@llnl.gov; Conrado, Cynthia L.; Bogen, Kenneth T.; Stoker, A. Carol

    2003-07-01

    The United States (US) conducted nuclear weapons testing from 1946 to 1958 at Bikini and Enewetak Atolls in the northern Marshall Islands. Based on previous detailed dose assessments for Bikini, Enewetak, Rongelap, and Utirik Atolls over a period of 28 years, cesium-137 ({sup 137}Cs) at Bikini Atoll contributes about 85-89% of the total estimated dose through the terrestrial food chain as a result of uptake of {sup 137}Cs by food crops. The estimated integral 30, 50, and 70-year doses were based on the radiological decay of {sup 137}Cs (30-year half-life) and other radionuclides. However, there is a continuing inventory of {sup 137}Cs and {sup 90}Sr in the fresh water portion of the groundwater at all contaminated atolls even though the turnover rate of the fresh groundwater is about 5 years. This is evidence that a portion of the soluble fraction of {sup 137}Cs and {sup 90}Sr inventory in the soil is lost by transport to groundwater when rainfall is heavy enough to cause recharge of the lens, resulting in loss of {sup 137}Cs from the soil column and root zone of the plants. This loss is in addition to that caused by radioactive decay. The effective rate of loss was determined by two methods: (1) indirectly, from time-dependent studies of the {sup 137}Cs concentration in leaves of Pisonia grandis, Guettarda specosia, Tournefortia argentea (also called Messerschmidia), Scaevola taccada, and fruit from Pandanus and coconut trees (Cocos nucifera L.), and (2) more directly, by evaluating the {sup 137}Cs/{sup 90}Sr ratios at Bikini Atoll. The mean (and its lower and upper 95% confidence limits) for effective half-life and for environmental-loss half-life (ELH) based on all the trees studied on Rongelap, Bikini, and Enewetak Atolls are 8.5 years (8.0 years, 9.8 years), and 12 years (11 years, 15 years), respectively. The ELH based on the {sup 137}Cs/{sup 90}Sr ratios in soil in 1987 relative to the{sup 137}Cs/{sup 90}Sr ratios at the time of deposition in 1954 is less

  3. Orthogonal assembly of a designed ankyrin repeat protein-cytotoxin conjugate with a clickable serum albumin module for half-life extension.

    Science.gov (United States)

    Simon, Manuel; Frey, Raphael; Zangemeister-Wittke, Uwe; Plückthun, Andreas

    2013-11-20

    The generation of drug conjugates for safe and effective tumor targeting requires binding proteins tolerant to functionalization by rational engineering. Here, we show that Designed Ankyrin Repeat Proteins (DARPins), a novel class of binding proteins not derived from antibodies, can be used as building blocks for facile orthogonal assembly of bioconjugates for tumor targeting with tailored properties. DARPin Ec1, which targets the Epithelial Cell Adhesion Molecule (EpCAM), was genetically modified with a C-terminal cysteine for conjugation of the small molecule cytotoxin monomethylauristatin F (MMAF). In addition, it was N-terminally functionalized by metabolic introduction of the non-natural amino acid azidohomoalanine to enable linkage of site-specifically dibenzocyclooctyne-modified mouse serum albumin (MSA) for half-life extension using Cu(I)-free click chemistry. The conjugate MSA-Ec1-MMAF was assembled to obtain high yields of a pure and stable drug conjugate as confirmed by various analytical methods and in functional assays. The orthogonality of the assembly led to a defined reaction product and preserved the functional properties of all modules, including EpCAM-specific binding and internalization, FcRn binding mediated by MSA, and cytotoxic potency. Linkage of MMAF to the DARPin increased receptor-specific uptake of the drug while decreasing nonspecific uptake, and further coupling of the conjugate to MSA enhanced this effect. In mice, albumin conjugation increased the serum half-life from 11 min to 17.4 h, resulting in a more than 22-fold increase in the area-under-the-curve (AUC). Our data demonstrate the promise of the DARPin format for facile modular assembly of drug conjugates with improved pharmacokinetic performance for tumor targeting.

  4. Investigation of temperature effect on half-life periods of long-lived isomer sup 1 sup 8 sup 0 sup m Hf and sup 8 sup 7 sup m Sr

    CERN Document Server

    Alpatov, V G; Davydov, A V; Isaev, Y N; Kartashov, G R; Korotkov, M M; Samojlov, V M

    2001-01-01

    The experiments on measuring the half-life periods of the sup 1 sup 8 sup 0 sup m Hf and sup 8 sup 7 sup m Sr long-lived isomers at the room temperature and at 77 K with application of the HfO sub 2 , Sr(NO sub 3) sub 2 and SrCO sub 3 massive samples are described. The isomer states of the corresponding nuclei were formed by the samples irradiation through neutrons from the Pu-Be source. According to the Vysotski theory and other authors the surrounding of the gamma-active nuclei by a large number of the same nuclei in the basic state should lead to the T sub 1 sub / sub 2 growth due to distortion of the zero electromagnetic vacuum oscillations near the nuclear energy level value. Decrease in the sample temperature leads to the narrowing of the gamma-lines, especially for the Moessbauer low-energy transitions, which increases the resonance effect on the zero oscillations spectrum. Increase in the T sub 1 sub / sub 2 by 2.99 +- 0.87% was observed by cooling the sup 1 sup 8 sup 0 sup m Hf isomer sample, in the ...

  5. Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life

    Directory of Open Access Journals (Sweden)

    Glen Daniel

    2009-05-01

    -lysine-bradykinin and labradimil increased the blood half-life of Gd-DTPA sufficiently enough to increase significantly the tumor tissue Gd-DTPA area under the time-concentration curve. Conclusion Metabolically stable bradykinin B2 receptor agonists, methionine-lysine-bradykinin and labradimil, enhance the transvascular delivery of small chemotherapy drugs across the BBTB of malignant gliomas by increasing the blood half-life of the co-infused drug. The selectivity of the increase in drug delivery into the malignant glioma tissue, but not into normal brain tissue or skeletal muscle tissue, is due to the inherent porous nature of the BBTB of malignant glioma microvasculature.

  6. An Intelligent Method for Data Classification by Proposing a Value for Fields Missing Any Values On The Basis Of Recommendation Systems and K-Means Clustering

    Directory of Open Access Journals (Sweden)

    Elham Bozorgzadeh

    2016-06-01

    Full Text Available Data-mining is a procedure to extract knowledge from available data, and it has been taken into account in various sciences. All sciences dealing with Data-mining suffer from fields missing the value. when a field misses a value, it is difficulty considered in the algorithms. In other words, when a classifier is designed to locate the samples in their own classification, this feature missing the value creates some problems. Therefore, a procedure must be taken into account to solve this problem, and to increase classification precision. The method proposed in this article ties to fill the fields missing the value. The method proposed in this article includes three basic steps that involve finding similar samples, estimating the fields missing the value and computing the classification precisely after completing the fields missing the value. The results show that the values obtained by proposed method are more efficient than previous methods.

  7. New limit for the half-life of double beta decay of $^{94}$Zr to the first excited state of $^{94}$Mo

    CERN Document Server

    Dokania, N; Gupta, G; Pal, S; Pillay, R G; Rath, P K; Tretyak, V I; Garai, A; Krishnamoorthy, H; Ghosh, C; Raina, P K; Bhushan, K G

    2016-01-01

    Double Beta Decay is a phenomenon of fundamental interest for particle physics and the study of these transitions to the excited states is of relevance to the calculation of Nuclear Transition Matrix Element for the process. In the present work, double beta decay of $^{94}$Zr to the $2^{+}_{1}$ excited state of $^{94}$Mo at 871.1 keV is studied using a low background $\\sim$ 250 cm$^3$ HPGe detector. No evidence of this decay was found with a 232 g.y exposure of natural Zirconium. The lower half-life limit obtained for the double beta decay of $\\rm^{94}Zr$ to the $2^{+}_{1}$ excited state of $\\rm^{94}Mo$ is $T_{1/2} > 6.1 \\times 10^{19}$ y at 90\\% C.L. ($T_{1/2} > 2.0 \\times 10^{20}$ y at 68\\% C.L.), a significant improvement by an order of magnitude over the existing experimental limit at 68\\% C.L.

  8. Upregulation of the mammalian X chromosome is associated with enhanced transcription initiation, MOF-mediated H4K16 acetylation, and longer RNA half-life

    Science.gov (United States)

    Deng, Xinxian; Berletch, Joel B.; Ma, Wenxiu; Nguyen, Di Kim; Noble, William S.; Shendure, Jay; Disteche, Christine M.

    2013-01-01

    SUMMARY X upregulation in mammals increases levels of expressed X-linked transcripts to compensate for autosomal bi-allelic expression. Here, we present molecular mechanisms that enhance X expression at transcriptional and posttranscriptional levels. Active mouse X-linked promoters are enriched in the initiation form of RNA polymerase II (PolII-S5p) and in specific histone marks including H4K16ac and histone variant H2AZ. The H4K16 acetyltransferase MOF, known to mediate the Drosophila X upregulation, is also enriched on the mammalian X. Depletion of MOF or MSL1 in mouse ES cells causes a specific decrease in PolII-S5p and in expression of a subset of X-linked genes. Analyses of RNA half-life datasets show increased stability of mammalian X-linked transcripts. Both ancestral X-linked genes, defined as those conserved on chicken autosomes, and newly acquired X-linked genes are upregulated by similar mechanisms but to a different extent, suggesting that subsets of genes are distinctly regulated dependent on their evolutionary history. PMID:23523075

  9. pH-selective mutagenesis of protein-protein interfaces: in silico design of therapeutic antibodies with prolonged half-life.

    Science.gov (United States)

    Spassov, Velin Z; Yan, Lisa

    2013-04-01

    Understanding the effects of mutation on pH-dependent protein binding affinity is important in protein design, especially in the area of protein therapeutics. We propose a novel method for fast in silico mutagenesis of protein-protein complexes to calculate the effect of mutation as a function of pH. The free energy differences between the wild type and mutants are evaluated from a molecular mechanics model, combined with calculations of the equilibria of proton binding. The predicted pH-dependent energy profiles demonstrate excellent agreement with experimentally measured pH-dependency of the effect of mutations on the dissociation constants for the complex of turkey ovomucoid third domain (OMTKY3) and proteinase B. The virtual scanning mutagenesis identifies all hotspots responsible for pH-dependent binding of immunoglobulin G (IgG) to neonatal Fc receptor (FcRn) and the results support the current understanding of the salvage mechanism of the antibody by FcRn based on pH-selective binding. The method can be used to select mutations that change the pH-dependent binding profiles of proteins and guide the time consuming and expensive protein engineering experiments. As an application of this method, we propose a computational strategy to search for mutations that can alter the pH-dependent binding behavior of IgG to FcRn with the aim of improving the half-life of therapeutic antibodies in the target organism.

  10. Ligand-substitution mode capillary electrophoretic reactor: extending capillary electrophoretic reactor toward measurement of slow dissociation kinetics with a half-life of hours.

    Science.gov (United States)

    Iki, Nobuhiko; Takahashi, Mariko; Takahashi, Toru; Hoshino, Hitoshi

    2009-09-15

    A method employing capillary electrophoresis (CE) was developed to determine the rate constant of the very slow spontaneous dissociation of a complex species. The method uses a CE reactor (CER) to electrophoretically separate components from a complex zone and, thus, spontaneously dissociate a complex. The dissociation is accelerated by ligand substitution (LS) involving a competing ligand added to the electrophoretic buffer. The LS-CER method is validated using the dissociation of a Ti(IV)-catechin complex and EDTA as a competing ligand. There is good agreement between the spontaneous dissociation rate constant (k(d) = (1.64 +/- 0.63) x 10(-4) s(-1)) and the rate constant obtained by a conventional batchwise LS reaction (k(d) = (1.43 +/- 0.04) x 10(-4) s(-1)). Furthermore, the usefulness of the method is demonstrated using a Ti(IV)-tiron complex, for which k(d) = (0.51 +/- 0.43) x 10(-4) s(-1), corresponding to a half-life (t(1/2)) of 3.8 h. Notably, a single run of LS-CER for the Ti(IV) complex is completed within 40 min, implying that LS-CER requires a considerably shorter measurement time (roughly equal to t(1/2)) than conventional CER. LS-CER can be widely applied to determine the spontaneous dissociation rates of inorganic diagnostic and therapeutic reagents as well as of biomolecular complexes.

  11. Research on Half-life Measuring Index of Chinese Psychology Science Based on Bibliometrics%基于文献计量学的我国心理学学科半衰期分析

    Institute of Scientific and Technical Information of China (English)

    张艳琼

    2014-01-01

    文章对心理学学科文献的引用和被引情况进行统计分析,通过学科文献被引半衰期和引用半衰期指标及其相关影响因素的分析,发现:心理学学科引用半衰期明显长于被引半衰期;心理学学科非常注重参考和借鉴国外的研究成果,但引用外文文献的时效相对滞后,说明我国心理学研究落后于国际水平;基础心理学半衰期最长,发展与教育心理学半衰期最短,比较符合偏理论的学科半衰期较长,偏应用的学科半衰期较短的规律。%This paper makes a statistical analysis of research papers' citation. Through analyzing the indexes of half- life of literature and the reference factors, it is found that citing half-life is longer than cited half-life in psychology. It is important to take reference of foreign research achievements in psychology, but the cited foreign papers are lagging, which shows psychology in China lags behind international level. The half-life of basic psychology is longest, while the half-life of development and education psychology is shortest, which shows the rule that half-life of discipline that focus more on theory is longer than the discipline that focus more on application.

  12. Defining competencies for education in health care value: recommendations from the University of California, San Francisco Center for Healthcare Value Training Initiative.

    Science.gov (United States)

    Moriates, Christopher; Dohan, Daniel; Spetz, Joanne; Sawaya, George F

    2015-04-01

    Leaders in medical education have increasingly called for the incorporation of cost awareness and health care value into health professions curricula. Emerging efforts have thus far focused on physicians, but foundational competencies need to be defined related to health care value that span all health professions and stages of training. The University of California, San Francisco (UCSF) Center for Healthcare Value launched an initiative in 2012 that engaged a group of educators from all four health professions schools at UCSF: Dentistry, Medicine, Nursing, and Pharmacy. This group created and agreed on a multidisciplinary set of comprehensive competencies related to health care value. The term "competency" was used to describe components within the larger domain of providing high-value care. The group then classified the competencies as beginner, proficient, or expert level through an iterative process and group consensus. The group articulated 21 competencies. The beginner competencies include basic principles of health policy, health care delivery, health costs, and insurance. Proficient competencies include real-world applications of concepts to clinical situations, primarily related to the care of individual patients. The expert competencies focus primarily on systems-level design, advocacy, mentorship, and policy. These competencies aim to identify a standard that may help inform the development of curricula across health professions training. These competencies could be translated into the learning objectives and evaluation methods of resources to teach health care value, and they should be considered in educational settings for health care professionals at all levels of training and across a variety of specialties.

  13. Alterative application of five anticonvulsants according to the half life for the treatment of status epilepticus in children with severe viral encephalitis

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: Traditional subhibernation therapy may easily cause complications, such as respiratory depression and hyportension because of application of chlorpromazine hydrochloride and promethazine in a large dosage.OBJECTIVE: To observe therapeutic effect of modified subhibernation therapy (alterative application of five anticonvulsants according to the half life) on status epilepticus in children with severe viral encephalitis (VE).DESIGN: Contrast observation.SETTING: Department of Pediatrics, the First Hospital of Jilin University.PARTICIPANTS: The participants in present study were 96 patients withsevere viral encephalitis including 52 boys and 44 girls who received treatment in the Department of Pediatrics, the First Hospital of Jilin University from February 2000 to March 2006. All children met the diagnostic criteria of Zhufutong Practice Pediatrics (the seventh edition). Two weeks ago, they ever got upper respiratory infection or enteronitis and so on before the onset, spirit abnormal, behavior disorder, limbs act disorder, vomit, headache, convulsion,nervous system masculine signs such as limbs act disord, autonomic nerve damage manifestation, brain nerve palsy, dysreflexia, meningeal irritation sign, cerebrospinal fluid and electroencephalography (EEG)abnormity. All parents provided the confirmed consent. The patients were randomly divided into control group (n =40) and experimental group (n =56).METHODS: Patients in the control group received anticonvulsion, ice compress and routine treatment. The convulsion was treated with five drugs: 0.5 mg/kg wintermin and phenergan, respectively, 100 g/L chlorpromazine hydrochloride (0.5 mL/kg), 5 mg/kg luminal, 0.3 mg/kg ansiolin. When convulsion attacked,those five drugs were given alternatively; however, those were not given if the convulsion did not attack.Children in the experimental group were treated with improved subhibernation therapy based on routine treatment. The dosages of anticonvulsants were as the

  14. Studies on the mechanism of the epileptiform activity induced by U18666A. II. concentration, half-life and distribution of radiolabeled U18666A in the brain

    Energy Technology Data Exchange (ETDEWEB)

    Cenedella, R.J.; Sarkar, C.P.; Towns, L.

    1982-06-01

    The concentration, half-life, and distribution in brain of U18666A, a drug that can drastically alter cerebral lipids and induce a chronic epileptiform state, was determined following both acute and chronic drug administration. U18666A specifically labeled with tritium was prepared by custom synthesis. Brain levels of 1 x 10(-6)M and higher were reached soon after giving an acute 10-mg/kg dose (i.p. or s.c.) of U18666A containing 7-/sup 3/H-U18666A of known specific activity. A steady state concentration of 1 to 2 x 10(-6)M was reached with chronic injection of 10 mg/kg every 4th day, a treatment schedule that results in altered brain lipids and induction of epilepsy if begun soon after birth. The disappearance of U18666A from both brain and serum was described by two similar biexponential processes, a brief rapid clearance (t1/2 . 10 h) and a sustained and much slower one (t1/2 . 65 h). Brain levels of the drug were about 10 times higher than serum at all times examined. Few differences were seen in the regional distribution of radiolabeled drug in brain as determined by both direct analysis and by autoradiographic examination; but the drug did concentrate in lipid-rich subcellular fractions. For example, the synaptosome and myelin fractions each contained about 25-35% of both the total /sup 3/H-labeled drug and total lipid in whole brain. The lipid composition of these fractions was drastically altered in treated animals. In conclusion, the chronic epileptiform state induced by U18666A does not appear to involve localization of the drug in a specific brain region or particular cell type. Rather, the condition could involve localization of the drug in lipid-rich membranes and marked changes in the composition of these membranes.

  15. Long circulating half-life and high tumor selectivity of the photosensitizer meta-tetrahydroxyphenylchlorin conjugated to polyethylene glycol in nude mice grafted with a human colon carcinoma.

    Science.gov (United States)

    Westerman, P; Glanzmann, T; Andrejevic, S; Braichotte, D R; Forrer, M; Wagnieres, G A; Monnier, P; van den Bergh, H; Mach, J P; Folli, S

    1998-06-10

    In a mode of nude mice bearing a human colon carcinoma xenograft, the biodistribution and tumor localization of metatetrahydroxyphenylchlorin (m-THPC) coupled to polyethylene glycol (PEG) were compared with those of the free form of this photosensitizer used in photodynamic therapy (PDT). At different times after i.v. injection of both forms of 125I-labeled photosensitizer, m-THPC-PEG gave on average a 2-fold higher tumor uptake than free m-THPC. In addition, at early times after injection, m-THPC-PEG showed a 2-fold longer blood circulating half-life and a 4-fold lower liver uptake than free m-THPC. The tumor to normal tissue ratios of radioactivity concentrations were always higher for m-THPC-PEG than for free m-THPC at any time point studied from 2 to 96 hr post-injection. Significant coefficients of correlation between direct fluorescence measurements and radioactivity counting were obtained within each organ tested. Fluorescence microscopy studies showed that m-THPC-PEG was preferentially localized near the tumor vessels, whereas m-THPC was more diffusely distributed inside the tumor tissue. To verify whether m-THPC-PEG conjugate remained phototoxic in vivo, PDT experiments were performed 72 hr after injection and showed that m-THPC-PEG was as potent as free m-THPC in the induction of tumor regression provided that the irradiation does for m-THPC-PEG conjugate was adapted to a well-tolerated 2-fold higher level. The overall results demonstrate first the possibility of improving the in vivo tumor localization of a hydrophobic dye used for PDT by coupling it to PEG and second that a photosensitizer conjugated to a macromolecule can remain phototoxic in vivo.

  16. Effect of Truncating AUC at 12, 24 and 48 hr When Evaluating the Bioequivalence of Drugs with a Long Half-Life.

    Science.gov (United States)

    Moreno, Isabel; Ochoa, Dolores; Román, Manuel; Cabaleiro, Teresa; Abad-Santos, Francisco

    2016-01-01

    Bioequivalence studies of drugs with a long half-life require long periods of time for pharmacokinetic sampling. The latest update of the European guideline allows the area under the curve (AUC) truncated at 72 hr to be used as an alternative to AUC0-t as the primary parameter. The objective of this study was to evaluate the effect of truncating the AUC at 48, 24 and 12 hr on the acceptance of the bioequivalence criterion as compared with truncation at 72 hr in bioequivalence trials. The effect of truncated AUC on the within-individual coefficient of variation (CVw) and on the ratio of the formulations was also analysed. Twenty-eight drugs were selected from bioequivalence trials. Pharmacokinetic data were analysed using WinNonLin 2.0 based on the trapezoidal method. Analysis of variance (ANOVA) was performed to obtain the ratios and 90% confidence intervals for AUC at different time-points. The degree of agreement of AUC0-72 in relation to AUC0-48 and AUC0-24, according to the Landis and Koch classification, was 'almost perfect'. Statistically significant differences were observed when the CVw of AUC truncated at 72, 48 and 24 hr was compared with the CVw of AUC0-12. There were no statistically significant differences in the AUC ratio at any time-point. Compared to AUC0-72, Pearson's correlation coefficient for mean AUC, AUC ratio and AUC CVw was worse for AUC0-12 than AUC0-24 or AUC0-48. These preliminary results could suggest that AUC truncation at 24 or 48 hr is adequate to determine whether two formulations are bioequivalent.

  17. Use of expression-enhancing terminators in Saccharomyces cerevisiae to increase mRNA half-life and improve gene expression control for metabolic engineering applications.

    Science.gov (United States)

    Curran, Kathleen A; Karim, Ashty S; Gupta, Akash; Alper, Hal S

    2013-09-01

    Control of gene and protein expression of both endogenous and heterologous genes is a key component of metabolic engineering. While a large amount of work has been published characterizing promoters for this purpose, less effort has been exerted to elucidate the role of terminators in yeast. In this study, we characterize over 30 terminators for use in metabolic engineering applications in Saccharomyces cerevisiae and determine mRNA half-life changes to be the major cause of the varied protein and transcript expression level. We demonstrate that the difference in transcript level can be over 6.5-fold even for high strength promoters. The influence of terminator selection is magnified when coupled with a low-expression promoter, with a maximum difference in protein expression of 11-fold between an expression-enhancing terminator and the parent plasmid terminator and over 35-fold difference when compared with a no-terminator baseline. This is the first time that terminators have been investigated in the context of multiple promoters spanning orders of magnitude in activity. Finally, we demonstrate the utility of terminator selection for metabolic engineering by using a mutant xylose isomerase gene as a proof-of-concept. Through pairing an expression-enhancing terminator with a low-expression promoter, we were able to achieve the same phenotypic result as with a promoter considerably higher in strength. Moreover, we can further boost the phenotype of the high-strength promoter by pairing it with an expression-enhancing terminator. This work highlights how terminator elements can be used to control metabolic pathways in the same way that promoters are traditionally used in yeast. Together, this work demonstrates that terminators will be an important part of heterologous gene expression and metabolic engineering for yeast in the future.

  18. First measurements on how pressure affects the half-life of 22Na: Comparison to theory and analog to 40K

    Science.gov (United States)

    Lee, K. K.; Nelson, R. O.; Rundberg, R.; Steinle-Neumann, G.

    2007-12-01

    Radioactive decay plays a central role in planetary sciences as appropriate decay schemes are used to date geological and astronomical processes and radioactivity provides an important source of heat in planetary bodies, both in their early history during accretion and differentiation and also over geological times. The most important isotopes that currently heat the Earth are 40K, 232Th, 235U and 238U. As radioactive decay is a nuclear process it is considered to be insensitive to external factors such as pressure or chemical environment. This has been shown to be true for α, β+ and β- processes, however, electron capture decay is dependent on the electron charge density at the nucleus of a compound, which is sensitive to the external environment. Using high-resolution Ge gamma-ray detectors to make relative measurements with 137Cs and the positron decay of 22Na, we measure how pressure affects the half-life of 22Na due to electron-capture decay. Our systematics look favorable for observing this small effect. We will compare our preliminary measurements with complementary ab-initio all-electron computations using the linearized augmented plane wave method (LAPW). Using 22Na as an analog for 40K, our results suggest that the pressure effect for 40K, combined with the opposing effects of high temperatures, will have little, discernible effect on the heat production in the deep Earth as our predicted changes are smaller than the uncertainties in the total decay constant for 40K. This work was supported in part by the Carnegie/DOE Alliance Center (CDAC), through the Stewardship Science Academic Alliances Program of the U.S. Department of Energy. The LANSCE facility is operated, and portions of this work were performed, by Los Alamos National Security, LLC, funded by the U.S. Department of Energy under Contract No. DE-AC52- 06NA25396.

  19. Environmental Metabolic Footprinting (EMF) vs. half-life: a new and integrative proxy for the discrimination between control and pesticides exposed sediments in order to further characterise pesticides' environmental impact.

    Science.gov (United States)

    Salvia, Marie-Virginie; Ben Jrad, Amani; Raviglione, Delphine; Zhou, Yuxiang; Bertrand, Cédric

    2017-06-28

    Pesticides are regularly used for a variety of applications and are disseminated throughout the environment. These substances may have significant negative impacts. To date, the half-life, t1/2, was often used to study the fate of pesticides in environmental matrices (water, soil, sediment). However, this value gives limited information. First, it does not evaluate the formation of by-products, resulting in the need for additional experiments to be performed to evaluate biodegradation and biotransformation products. T1/2 also fails to consider the chemical's impact on biodiversity. Resilience time, a new and integrative proxy, was recently proposed as an alternative to t1/2, with the potential to evaluate all the post-application effects of the chemical on the environment. The 'Environmental Metabolic Footprinting' (EMF) approach, giving an idea of the resilience time, was used to evaluate the impact of botanicals on soil. The goal is to optimise the EMF to study the impact of a microbial insecticide, the Bacillus thuringiensis israelensis (Bti), on sediment. The difficulty of this work lies in the commercial solution of Bti that is really complex, and this complexity yields chromatograms that are extremely difficult to interpret; t1/2 cannot be used. No methodologies currently exist to monitor the impact of these compounds on the environment. We will test the EMF to determine if it is sensitive enough to tolerate such complex mixtures. A pure chemical insecticide, the α-cypermethrin, will be also studied. The article shows that the EMF is able to distinguish meta-metabolome differences between control and exposed (with Bti) sediments.

  20. The value of ProMED-mail for the Early Warning Committee in the Netherlands : more specific approach recommended

    NARCIS (Netherlands)

    Zeldenrust, M E; Rahamat-Langendoen, J C; Postma, M.J.; van Vliet, J A

    2008-01-01

    This article describes a retrospective and descriptive study into the added value of ProMED-mail--the global electronic reporting system for outbreaks of emerging infectious diseases and toxins maintained by the International Society for Infectious Diseases--as an early warning system for The Nether

  1. The value of ProMED-mail for the Early Warning Committee in the Netherlands : more specific approach recommended

    NARCIS (Netherlands)

    Zeldenrust, M E; Rahamat-Langendoen, J C; Postma, M.J.; van Vliet, J A

    2008-01-01

    This article describes a retrospective and descriptive study into the added value of ProMED-mail--the global electronic reporting system for outbreaks of emerging infectious diseases and toxins maintained by the International Society for Infectious Diseases--as an early warning system for The

  2. The Value of Energy Performance and Green Attributes in Buildings: A Review of Existing Literature and Recommendations for Future Research

    Energy Technology Data Exchange (ETDEWEB)

    Stuart, Elizabeth

    2011-09-07

    Labels, certifications, and rating systems for energy efficiency performance and “green” attributes of buildings have been available in the U.S. for over 10 years, and used extensively in the European Union and Australia for longer. Such certifications and ratings can make energy efficiency more visible, and could help spur demand for energy efficiency if these designations are shown to have a positive impact on sales or rental prices. This policy brief discusses the findings and methodologies from recent studies on this topic, and suggests recommendations for future research. Although there have been just a handful of studies within the last 10 years that have investigated these effects, a few key findings emerge: To maximize sales price impact, label or rating information must be disclosed early and visibly in the sales process; The approach to evaluating energy efficiency labels (e.g., ENERGY STAR) and general “green” certifications (e.g., LEED or GreenPoint Rated) may need to be different, depending on the type, vintage and market penetration of the label; Collaborative efforts to promote label adoption and build a large dataset of labeled buildings will be required to produce reliable study results.

  3. The Value of Energy Performance and Green Attributes in Buildings: A Review of Existing Literature and Recommendations for Future Research

    Energy Technology Data Exchange (ETDEWEB)

    Stuart, Elizabeth

    2011-09-07

    Labels, certifications, and rating systems for energy efficiency performance and “green” attributes of buildings have been available in the U.S. for over 10 years, and used extensively in the European Union and Australia for longer. Such certifications and ratings can make energy efficiency more visible, and could help spur demand for energy efficiency if these designations are shown to have a positive impact on sales or rental prices. This policy brief discusses the findings and methodologies from recent studies on this topic, and suggests recommendations for future research. Although there have been just a handful of studies within the last 10 years that have investigated these effects, a few key findings emerge: To maximize sales price impact, label or rating information must be disclosed early and visibly in the sales process; The approach to evaluating energy efficiency labels (e.g., ENERGY STAR) and general “green” certifications (e.g., LEED or GreenPoint Rated) may need to be different, depending on the type, vintage and market penetration of the label; Collaborative efforts to promote label adoption and build a large dataset of labeled buildings will be required to produce reliable study results.

  4. IMPACT OF THE SELECTIVITY AND HALF-LIFE OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ON THE DEVELOPMENT OF SUBCLINICAL KIDNEY INJURY

    Directory of Open Access Journals (Sweden)

    S. A. Zhigalov

    2016-01-01

    Full Text Available Objective: to investigate the impact of the selectivity and half-life of nonsteroidal anti-inflammatory drugs (NSAIDs on the development of subclinical kidney injury (SKI. A standard physical examination was made.Patients and methods. The study included 80 patients with a verified rheumatoid arthritis (RA diagnosis. The patients filled in a specially designed questionnaire to explore a history of drug use. As markers of SKI, the investigators determined the concentrations of albumin, α1-microglobulin (α1-MG, alanine aminotransferase (ALT, and alkaline phosphatase (ALP in urine. A control group consisted of 20 apparently healthy individuals matched for age and gender.Results. 80 patients suffering from RA received drug therapy. Of them, 82.5% and 87.5% took NSAIDs and disease-modifying antirheumatic drugs, respectively. The levels of SKI markers were compared in three groups of the examinees: 1 NSAID-treated patients; 2 NSAID-untreated patients; 3 a control group. There were statistically significant differences between all the groups (p<0.05. Comparison of the levels of SKI markers revealed no statistically significant difference in the groups receiving selective cyclooxygenase-2 (COX-2 inhibitors (n=18.6%, in those taking nonselective ones (n=68.6%, and the control group. Comparison of the levels of SKI markers demonstrated significantly higher >< 0.05. Comparison of the levels of SKI markers revealed no statistically significant difference in the groups receiving selective cyclooxygenase-2 (COX-2 inhibitors (n=18.6%, in those taking nonselective ones (n=68.6%, and the control group. Comparison of the levels of SKI markers demonstrated significantly higher α1-MG levels in the long-acting NSAID groups (n=8.6% than in the short-acting NSAID group (n=80%. ALT, ALP, and microalbuminuria showed a similar trend that failed to reach statistical significance.Conclusion: NSAIDs remain a group of medications with a certain nephrotoxic effect. At the

  5. [Search for convergence between values of indicators for evaluating oral cavity status as recommended by WHO and presence of fungi or Trichomonas tenax].

    Science.gov (United States)

    Kurnatowska, A J

    1993-01-01

    There is a lack in the literature of publications analyzing values of indicators for evaluation of oral cavity status, namely: PUW number (cariogenic indicator), Russell's indicator (changes in the paradontium) and Greene-Vermillion indicator (hygiene) recommended by WHO. This prompted the study for search of convergence between values of listed indicators and presence of fungi in ontocenosis of oral cavity in patients reporting to the stomatologist because of several reasons. Among 355 patients in oral cavity of whom presence of fungi was detected, the highest frequency of this invasion was noted in patients with diseases of the paradontium, while lowest percentage was noted in patients with confirmed caries. Convergence between values of tested indicators and presence of fungi was evaluated by application of convergence coefficient of Yule and the Pearson's test (Chi2). No significant correlation between presence of fungi and changes in the oral cavity was found.

  6. 长效人白细胞介素4拮抗剂的研究%Interleukin-4 antagonists with longer half-life in plasma

    Institute of Scientific and Technical Information of China (English)

    宋西勇; 唱韶红; 刘波; 巩新; 吴军

    2014-01-01

    Objective To develop an interleukin-4(IL-4) antagonist named M5-IgG1Fc protein constructed by genetic engineering of antibody Fc fragment-cytokine mutein fusion protein which has a long half-life time in plasma.M5-IgG1 Fc protein binds to IL-4 receptor but cannot activate downstream signalling pathway , which provides a basis for drug develop-ment for allergic diseases .Methods The synthesized interleukin-4 mutant gene ( named M5 ) was cloned into the expres-sion vector pBV220 and transformed into E.coli DH5α.Chimeric gene M5-IgG1Fc obtained by overlap extension (SOE) method was transformed into glycoengineered Pichia pastoris GJK01 through expression vector pPICZαA .Then M5-IgGFc fusion protein was obtained by protein purification after being induced by methanol in 72 hours.The anti-IL-4 biologicial ac-tivity assay of M5 and M5-IgG1 Fc was performed with CTLL-2/IL-4R cells and detected with MTT colormetry .Finally,the half-life time of M5 and M5-IgG1 Fc protein in mice was compared by detecting the remaining amount in plasma with ELISA kit.Results The M5 protein expressed in E.coli and M5-IgG1 Fc fusion protein expressed in P.pastoris GJK01 both had IL-4 antagonistic bioactivity .The EC50 of both, which inhibited 5.6 ×10 -2 nmol/ml of IL-4, were 0.31 ±0.05 and 0.77 ± 0.03 nmol/ml,respectively.The maximum of M5 in plasma at 0.5 h was 5.8 ×10 -2 nmol/ml but the remaining amount was 2.8%of the maximum at 2 h.M5 protein could not be detected after administration at 8 h because of the detection line . The maximum of M5-IgG1 Fc fusion protein was 4.7 ×10 -2 nmol/ml,while fusion protein M5-IgG1 Fc decreased to 4.3%of its maximum at 120 h and could not be detected at 168 h.Conclusion M5 protein has IL-4 antagonistic bioactivity .M5-IgG1 Fc fusion protein expressed in glycoengineered P.pastoris GJK01 has IL-4 antagonistic bioactivity and long retention time in mice,which can be potentially used for treatment of allergic diseases .%目的

  7. 基于Vague值的非个性化产品推荐研究%Study of non-personalized recommender systems based on vague value

    Institute of Scientific and Technical Information of China (English)

    崔春生; 苏白云

    2012-01-01

    Non-personalized recommender systems has become a popular online advertising method due to the comprehensive applications of users and products. In the previous research, Vague value method has been used to study the recommender system, which is approved to be used in this field. The general characteristics and advantages of non-personalized recommender are reviewed. Hence, the feasibilities of using eigenvalue method and the "Matthew Effect" score function method in products-ranking are studied based on description of products by Vague set. The effectiveness and coconscious of two methods are then proved with examples.%在网络用户和网络产品急剧攀升的背景下,非个性化产品推荐成为一种很好的网络广告手段,已有的研究中,Vague集方法已被应用于推荐系统中,并取得了较好的效果.分析了非个性化产品推荐的一般特征和优点;借助Vague值描述的产品,研究了特征值方法和“马太效应”记分函数方法运用于产品排序的可行性;最后,通过实例验证了两种方法的在非个性化产品推荐中的有效性和一致性.

  8. Shiga toxin type 2 (Stx2), a potential agent of bioterrorism, has a short distribution and a long elimination half-life, and induces kidney and thymus lesions in rats.

    Science.gov (United States)

    Liu, Yue-Nan; Wang, Sheng-Han; Li, Tao; Wang, Qin; Tu, Wei; Cai, Kun; Hou, Xiao-Jun; Tian, Ren-Mao; Gao, Xiang; Liu, Hao; Xiao, Le; Shi, Jing; Cheng, Yuan-Guo; Li, Jian-Chun; Wang, Hui

    2011-09-01

    Shiga toxin type 2, a major virulence factor produced by the Shiga toxin-producing Escherichia coli, is a potential toxin agent of bioterrorism. In this study, iodine-125 (125I) was used as an indicator to describe the in vivo Stx2 biodistribution profile. The rats were injected intravenously (i.v.) with 125I-Stx2 at three doses of 5.1-127.5 μg/kg body weight. Stx2 had a short distribution half-life (t (1/2)α, less than 6 min) and a long elimination half-life in rat. The toxicokinetics of Stx2 in rats was dose dependent and nonlinear. Stx2 concentrations in various tissues were detected at 5-min, 0.5-h, and 72-h postinjection. High radioactivity was found in the lungs, kidneys, nasal turbinates, and sometimes in the eyes, which has never been reported in previous studies. In a preliminary assessment, lesions were found in the kidney and thymus.

  9. Measurement of the double-β decay half-life and search for the neutrinoless double-β decay of 48Ca with the NEMO-3 detector

    Science.gov (United States)

    Waters, David; Vilela, Cristóvão; NEMO-3 collaboration

    2017-09-01

    Neutrinoless double-β decay is a powerful probe of lepton number violating processes that may arise from Majorana terms in neutrino masses, or from supersymmetric, left-right symmetric, and other extensions of the Standard Model. Of the candidate isotopes for the observation of this process, 48Ca has the highest Qββ -value, resulting in decays with energies significantly above most naturally occurring backgrounds. The nucleus also lends itself to precise matrix element calculations within the nuclear shell model. We present the world’s best measurement of the two-neutrino double-β decay of 48Ca, obtained by the NEMO-3 collaboration using 5.25 yr of data recorded with a 6.99 g sample of isotope, yielding ≈ 150 events with a signal to background ratio larger than 3. Neutrinoless modes of double-β decay are also investigated, with no evidence of new physics. Furthermore, these results indicate that two-neutrino double-β decay would be the main source of background for similar future searches using 48Ca with significantly larger exposures.

  10. The recommended Threshold Limit Values for heat exposure fail to maintain body core temperature within safe limits in older working adults.

    Science.gov (United States)

    Lamarche, Dallon T; Meade, Robert D; D'Souza, Andrew W; Flouris, Andreas D; Hardcastle, Stephen G; Sigal, Ronald J; Boulay, Pierre; Kenny, Glen P

    2017-09-01

    The American Conference of Governmental and Industrial Hygienists (ACGIH®) Threshold Limit Values (TLV® guidelines) for work in the heat consist of work-rest (WR) allocations designed to ensure a stable core temperature that does not exceed 38°C. However, the TLV® guidelines have not been validated in older workers. This is an important shortcoming given that adults as young as 40 years demonstrate impairments in their ability to dissipate heat. We therefore evaluated body temperature responses in older adults during work performed in accordance to the TLV® recommended guidelines. On three occasions, 9 healthy older (58 ± 5 years) males performed a 120-min work-simulated protocol in accordance with the TLV® guidelines for moderate-to-heavy intensity work (360 W fixed rate of heat production) in different wet-bulb globe temperatures (WBGT). The first was 120 min of continuous (CON) cycling at 28.0°C WBGT (CON[28°C]). The other two protocols were 15-min intermittent work bouts performed with different WR cycles and WBGT: (i) WR of 3:1 at 29.0°C (WR3:1[29°C]) and (ii) WR of 1:1 at 30.0°C (WR1:1[30°C]). Rectal temperature was measured continuously. The rate of change in mean body temperature was determined via thermometry (weighting coefficients: rectal, 0.9; mean skin temperature, 0.1) and direct calorimetry. Rectal temperature exceeded 38°C in all participants in CON[28°C] and WR3:1[29°C] whereas a statistically similar proportion of workers exceeded 38°C in WR1:1[30°C] (χ(2); P = 0.32). The average time for rectal temperature to reach 38°C was: CON[28°C], 53 ± 7; WR3:1[29°C], 79 ± 11; and WR1:1[30°C], 100 ± 29 min. Finally, while a stable mean body temperature was not achieved in any work condition as measured by thermometry (i.e., >0°C·min(-1); all Pheat balance as determined by direct calorimetry was achieved in WR3:1[29°C] and WR1:1[30°C] (both P ≥ 0.08). Our findings indicate that the TLV® guidelines do not prevent body core

  11. Recommender Systems

    CERN Document Server

    Lü, Linyuan; Yeung, Chi Ho; Zhang, Yi-Cheng; Zhang, Zi-Ke; Zhou, Tao

    2012-01-01

    The ongoing rapid expansion of the Internet greatly increases the necessity of effective recommender systems for filtering the abundant information. Extensive research for recommender systems is conducted by a broad range of communities including social and computer scientists, physicists, and interdisciplinary researchers. Despite substantial theoretical and practical achievements, unification and comparison of different approaches are lacking, which impedes further advances. In this article, we review recent developments in recommender systems and discuss the major challenges. We compare and evaluate available algorithms and examine their roles in the future developments. In addition to algorithms, physical aspects are described to illustrate macroscopic behavior of recommender systems. Potential impacts and future directions are discussed. We emphasize that recommendation has a great scientific depth and combines diverse research fields which makes it of interests for physicists as well as interdisciplinar...

  12. A comparison of food-based recommendations and nutrient values of three food guides: USDA's MyPyramid, NHLBI's Dietary Approaches to Stop Hypertension Eating Plan, and Harvard's Healthy Eating Pyramid.

    Science.gov (United States)

    Reedy, Jill; Krebs-Smith, Susan M

    2008-03-01

    The purpose of this research was to compare food-based recommendations and nutrient values of three food guides: the US Department of Agriculture's MyPyramid; the National Heart, Lung, and Blood Institute's Dietary Approaches to Stop Hypertension Eating Plan, and Harvard University's Healthy Eating Pyramid. Estimates of nutrient values associated with following each of the food guides at the 2,000-calorie level were made using a composite approach. This approach calculates population-weighted nutrient composites for each food group and subgroup, assuming average choices within food groups. Nutrient estimates were compared to the Dietary Reference Intakes and other goals and limits. Recommendations were similar regarding almost all food groups for both the type and amount of foods. Primary differences were seen in the types of vegetables and protein sources recommended and the amount of dairy products and total oil recommended. Overall nutrient values were also similar for most nutrients, except vitamin A, vitamin E, and calcium. These food guides were derived from different types of nutrition research, yet they share consistent messages: eat more fruits, vegetables, legumes, and whole grains; eat less added sugar and saturated fat; and emphasize plant oils.

  13. Modification of the Fc Region of a Human Anti-oncostatin M Monoclonal Antibody for Higher Affinity to FcRn Receptor and Extension of Half-life in Cynomolgus Monkeys.

    Science.gov (United States)

    Nnane, Ivo P; Han, Chao; Jiao, Qun; Tam, Susan H; Davis, Hugh M; Xu, Zhenhua

    2017-01-28

    The purpose of this study was to evaluate the pharmacokinetics (PK) of anti-oncostatin M (OSM) IgG1 monoclonal antibodies, CNTO 1119 and its Fc variant (CNTO 8212), which incorporates the LS(Xtend) mutation to extend terminal half-life (T1/2 ), after a single intravenous (IV) or subcutaneous (SC) administration in cynomolgus monkeys, and to predict human PK. In study 1, single doses of CNTO 1119 and CNTO 8212 were administered IV or SC at 3 mg/kg to cynomolgus monkeys (n = 3 per group). In study 2, single doses of CNTO 8212 were administered IV at 1, 5 or 20 mg/kg, or SC at 5 mg/kg to cynomolgus monkeys (n = 5 per group). Serial blood samples were collected for assessment of serum concentrations of CNTO 1119 and/or CNTO 8212. A two-compartment population PK model with first-order elimination was utilized to simultaneously describe the serum concentrations of CNTO 1119 and CNTO 8212 over time after IV and SC administration in cynomolgus monkeys. The typical population PK parameter estimates for CNTO 1119 in cynomolgus monkeys were clearance (CL) = 2.81 mL/day/kg, volume of distribution of central compartment (V1 ) = 31.3 mL/kg, volume of distribution of peripheral compartment (V2 ) = 23.3 mL/kg, absolute bioavailability (F) = 0.84 and T1/2 = 13.4 days. In comparison, the typical population PK parameter estimates for CNTO 8212 in cynomolgus monkeys were CL = 1.41 mL/day/kg, V1 = 39.8 mL/kg, V2 = 32.6 mL/kg, F = 0.75 and T1/2 = 35.7 days. The mean CL of CNTO 8212 was ~50% lower compared with that for CNTO 1119 in cynomolgus monkeys. The overall volume of distribution (V1 +V2 ) for CNTO 8212 was about 32% larger compared with that for CNTO 1119, but generally similar to the vascular volume in cynomolgus monkeys. The T1/2 of CNTO 8212 was significantly (p monkeys. Thus, the modification of the Fc portion of an anti-OSM IgG1 mAb for higher FcRn binding affinity resulted in lower systemic clearance and a longer terminal half-life in cynomolgus monkeys. CNTO 8212

  14. Recommended Wilderness

    Data.gov (United States)

    National Park Service, Department of the Interior — Recommended wilderness is an Arcview shapefile representing the porposed wilderness areas throughout the park. The boundaries for this data set were digitized by...

  15. Recommender systems

    CERN Document Server

    Kembellec, Gérald; Saleh, Imad

    2014-01-01

    Acclaimed by various content platforms (books, music, movies) and auction sites online, recommendation systems are key elements of digital strategies. If development was originally intended for the performance of information systems, the issues are now massively moved on logical optimization of the customer relationship, with the main objective to maximize potential sales. On the transdisciplinary approach, engines and recommender systems brings together contributions linking information science and communications, marketing, sociology, mathematics and computing. It deals with the understan

  16. Cinacalcet and achievement of the NKF/K-DOQI recommended target values for bone and mineral metabolism in real-world clinical practice--the ECHO observational study

    DEFF Research Database (Denmark)

    Urena, P.; Jacobson, S.H.; Zitt, E.

    2009-01-01

    /dl) at baseline, despite being prescribed conventional therapies. The proportions of patients achieving the recommended [NKF-K/DOQI(TM) (KDOQI(TM))] targets increased from baseline [4%, 39%, 40% and 46% for iPTH, phosphorus, calcium and calcium-phosphorus product (Ca x P), respectively] to Month 12 (28%, 48%, 51......% and 68%, respectively). At Month 12, 18% of patients had achieved the combined target for iPTH + Ca x P compared with 2% at baseline. Most patients (65%) received ... sevelamer; use of calcium-based phosphate binders increased by 5.6%. There was no unexpected safety or tolerability concerns. CONCLUSION: This analysis of current European clinical practice shows that-consistent with findings from randomized controlled trials and retrospective observational studies...

  17. "Pulmonary embolism diagnostics of pregnant patients: What is the recommended clinical pathway considering the clinical value and associated radiation risks of available imaging tests?"

    Science.gov (United States)

    Papadakis, Georgios Z; Karantanas, Apostolos H; Perisinakis, Kostas

    2017-07-28

    Pulmonary embolism (PE) during pregnancy remains the leading preventable cause of maternal morbidity and mortality in the developed countries. Diagnosis of PE in pregnant patients is a challenging clinical problem, since pregnancy-related physiologic changes can mimic signs and symptoms of PE. Patient mismanagement may result into unjustified anticoagulant treatment or unnecessary imaging tests involving contrast-related or/and radiation-related risks for both the expectant mother and embryo/fetus. On the other hand, missing or delaying diagnosis of PE could lead to life-threatening conditions for both the mother and the embryo/fetus. Thus, a timely and accurate diagnostic approach is required for the optimal management of pregnant patients with suspected PE. Aim of the current review is to discuss a pregnancy-specific clinical pathway for the early diagnosis of PE with non-ionizing radiation- and ionizing radiation-based imaging modalities taking into account previously reported data on diagnostic value of available imaging tests, and radiation related concerns. Copyright © 2017 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  18. The Result of Multiple I-131 Treatments on the Effective Half-Life of Retained Radioactivity in Patients Ablated for Differentiated Thyroid Cancer: Possible Evidence for Thyroid Remnant Function Impairment.

    Science.gov (United States)

    Okkalides, Demetrios

    2016-03-01

    The ablation of differentiated thyroid cancer by ingested I-131 depends on the activity absorbed by the remnant. This depends on the function of the thyroid cells and on the rate that radioactivity is excreted from the blood. The reduction of radioiodine is described by the effective half-life (EHL), which is the time taken to half the retained radioactivity. If the tumor recurs, more treatments are prescribed, often with escalating activities. Patients may receive several treatments during the evolution of the disease, and the total radioactivity administered (TRA) is the sum of all such activities. The patients' archived information permitted the calculation of EHL and TRA. The patient cohort processed here comprised 274 females and 101 males treated during 1997 to 2015. The TRA to the patients ranged between 1.1 and 129.5 GBq (average = 7.93 ± 9.9 GBq) and the EHL varied between 5.06 and 43.87 hours (average = 14.13 ± 5.7 hours). The data were processed as follows: (a) the EHL corresponding to the last treatment of each patient was plotted against TRA to patients who were treated once and to those treated several times for comparison and (b) using a small subgroup of 16 patients who were treated at least 5 times, the EHL and TRA corresponding to each treatment of each patient were plotted. A function of the form y = p-k·ln(x) was fitted on the data in all graphs and k was calculated. For patients treated once, EHL was independent of TRA. A decrease was seen in (a) multitreated patients, with the gradient (k) ranging between -0.541 and -13.880 and (b) 13 out of 16 patients, with the gradient (k) ranging between -5.55 and -31.17, both indicating an impairment of the remnant function, perhaps identified as "stunning." Since this is not avoidable, the uptake may be boosted by splitting the prescribed activity into low radioactivity fractions, which will also reduce patient hospitalization.

  19. Oncology Journals Cited Half - life and Its Connection with Other Indicators Such as Impact Factors and Total Cited Frequen%肿瘤医学期刊被引半衰期及其与影响因子、总被引频次等计量指标的关系

    Institute of Scientific and Technical Information of China (English)

    戴丽琼

    2012-01-01

    对《2011年版中国期刊引证报告(扩刊版)》中肿瘤医学期刊被引半衰期、影响因子、引用半衰期、总被引频次、平均引文数等的相关关系进行分析,并对期刊编辑和期刊管理工作提出建议。%The paper analyzes the connection among citated half - life, impact factors, citation half - life, total cited frequency of oncology journals included in " Chinese S & T Journal Citation Report (2011 )", proposes advices on journal editing and management work.

  20. Measurement of the double- β decay half-life of 136Xe with the KamLAND-Zen experiment

    Energy Technology Data Exchange (ETDEWEB)

    Gando, A.; Gando, Y.; Hanakago, H.; Ikeda, H.; Inoue, K.; Kato, R.; Koga, M.; Matsuda, S.; Mitsui, T.; Nakada, T.; Nakamura, K.; Obata, A.; Oki, A.; Ono, Y.; Shimizu, I.; Shirai, J.; Suzuki, A.; Takemoto, Y.; Tamae, K.; Ueshima, K.; Watanabe, H.; Xu, B. D.; Yamada, S.; Yoshida, H.; Kozlov, A.; Yoshida, S.; Banks, T. I.; Detwiler, J. A.; Freedman, S. J.; Fujikawa, B. K.; Han, K.; O’Donnell, T.; Berger, B. E.; Efremenko, Y.; Karwowski, H. J.; Markoff, D. M.; Tornow, W.; Enomoto, S.; Decowski, M. P.

    2012-04-19

    We present results from the KamLAND-Zen double-beta decay experiment based on an exposure of 77.6 days with 129 kg of 136Xe. The measured two-neutrino double-beta decay half-life of 136Xe is T$2ν\\atop{1/2}$ = 2.38 ± 0.02(stat) ± 0.14(syst) x1021 yr, consistent with a recent measurement by EXO-200. We also obtain a lower limit for the neutrinoless double-beta decay half-life, T$0ν\\atop{1/2}$ > 5.7 x 1024 yr at 90% C.L.

  1. Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR.

    Science.gov (United States)

    Suzuki, Takuo; Ishii-Watabe, Akiko; Tada, Minoru; Kobayashi, Tetsu; Kanayasu-Toyoda, Toshie; Kawanishi, Toru; Yamaguchi, Teruhide

    2010-02-15

    The neonatal FcR (FcRn) binds to the Fc domain of IgG at acidic pH in the endosome and protects IgG from degradation, thereby contributing to the long serum half-life of IgG. To date, more than 20 mAb products and 5 Fc-fusion protein products have received marketing authorization approval in the United States, the European Union, or Japan. Many of these therapeutic proteins have the Fc domain of human IgG1; however, the serum half-lives differ in each protein. To elucidate the role of FcRn in the pharmacokinetics of Fc domain-containing therapeutic proteins, we evaluated the affinity of the clinically used human, humanized, chimeric, or mouse mAbs and Fc-fusion proteins to recombinant human FcRn by surface plasmon resonance analysis. The affinities of these therapeutic proteins to FcRn were found to be closely correlated with the serum half-lives reported from clinical studies, suggesting the important role of FcRn in regulating their serum half-lives. The relatively short serum half-life of Fc-fusion proteins was thought to arise from the low affinity to FcRn. The existence of some mAbs having high affinity to FcRn and a short serum half-life, however, suggested the involvement of other critical factor(s) in determining the serum half-life of such Abs. We further investigated the reason for the relatively low affinity of Fc-fusion proteins to FcRn and suggested the possibility that the receptor domain of Fc-fusion protein influences the structural environment of the FcRn binding region but not of the FcgammaRI binding region of the Fc domain.

  2. Semiperiodo de la literatura científica en Biblioteconomía y Documentación y la influencia de los aspectos temáticos The half-life of scientific literature in library and information science and the influence of thematic issues

    Directory of Open Access Journals (Sweden)

    J.A. Martínez-Comeche

    2010-08-01

    Full Text Available Este trabajo presenta el cálculo del semiperiodo o vida media de las referencias en 28 revistas españolas y anglosajonas de Biblioteconomía y Documentación siguiendo la fórmula de Burton y Kebler, durante el año 2006. Se analiza posteriormente la posible relación con los contenidos presentes en las revistas, y se extraen conclusiones sobre qué temas nucleares del área imponen básicamente dicho semiperiodo, dando lugar a lo que puede considerarse como el semiperiodo de la literatura científica en Biblioteconomía y Documentación, y señalando qué temas tienden a aumentar o disminuir dicho semiperiodo cuando están presentes en una determinada revista. De esta forma el semiperiodo podría considerarse un indicio del contenido temático de la revista.Following the formula developed by Burton and Kebler, this paper presents a calculation of the half-life of bibliographical references appearing in twenty-eight English- and Spanish-language Library and Information Science journals in the year 2006. An analysis of the relationship of this phenomenon to content is carried out in order to identify the nuclear topic areas that in turn determine this half-life. Moreover, the paper provides an assessment of those subject areas for each of the journals studied that tend to lengthen or shorten the half-life of a given bibliographic reference. As such, the bibliographic half-life may be considered an indicator of the thematic inclination of a given journal.

  3. 半衰期为数天的惰性气体和卤素裂变产物在UO2颗粒中的扩散与释放%Diffusion and Release of Noble Gas and Halogen Fission Products With Several Days Half-Life in UO2 Particle

    Institute of Scientific and Technical Information of China (English)

    房超

    2013-01-01

    在考虑吸附效应等物理过程的基础上,得到了裂变产物在UO2颗粒中扩散与释放模型的严格解,并导出了不同反应堆运行状态下裂变产物累积释放份额F(t)、释放-产出比R(t)/B(t)的严格表达式.利用上述结果以及相应的近似解、数值解,对半衰期为数天的惰性气体和卤素裂变产物(131I、131Xem、133Xe和133Xem)在不同堆芯历史条件下的F(t)和R(t)/B(t)进行了比较计算.分析表明,F(t)与R(t)/B(t)的结果均有所差别,但当反应堆运行时间达一定长度后,它们的数值相等.此外,严格解去掉了近似解中不必要的保守性,也比数值解更符合物理实际.%The exact solutions of diffusion and release model of noble gas and halogen fission products in UO2 particle of HTGR were built under the conditions of adsorption effect and other physical processes. The corresponding release fractions (F(t)) and the ratio of release and productive amounts (R (t)/B (t)) of fission products were also derived. Furthermore, the F(t) and R(t)/B(t) of 131I, 131Xem, 133Xe and 133Xem whose half-lifes are several days in UO2 particle with the exact solutions, approximate solutions and corresponding numerical solutions under different temperature histories of reactor core were investigated. The results show that the F(t) and R(t)/B(t) are different in numerical values unless the time of release is long enough. The properties of conservation of exact solutions are much more reasonable than the ones of approximate solutions. It is also found that the results of exact solutions approach the actual working conditions more than the approximate and numerical solutions.

  4. The ICRP 2007 recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Streffer, C. [Chairman of ICRP Committee 2, Institute of Science and Ethics, University Duisburg-Essen, 45117 Essen (Germany)

    2007-07-01

    The last comprehensive International Commission on Radiological Protection (ICRP) recommendations have been published in 1991(1). Since that time new data in physics and biology that are relevant for radiological protection have appeared in the scientific literature. Also, the general thinking about safety standards at the workplace as well as for the protection of the public has developed. Thus, a review of the recommendations is needed. However, as the present standards have worked well, these new recommendations should build on the present ones. Only a process of further development should take place allowing for the following key points: - new biological and physical information and trends in the setting of safety standards; - improvement in the presentation of the recommendations; as much stability in the recommendations as is consistent with the new information and environmental aspects will be included. The fundamental principles of radiological protection will remain the same as they have been described in ICRP publication 60(1): Justification: Actions involving new exposures or changes in exposures of individuals have to be justified in advance. A positive net benefit must result. Optimisation: Exposures should be as low as reasonably achievable and should be optimised in relation to with dose constraints. Dose limits: The values will not to be changed from Publication 60. Dose constraints: Development of the concept proposed in Publication 60 will be explained. The ICRP Committees have prepared foundation documents in the fields for which they are responsible and their members have the corresponding expertise. These foundation documents will support the decisions and explain the various statements of the Main Commission in a broader sense. Some of them will be published as Annexes to the recommendations (Annex A: Biological and Epidemiological Information on Health Risks Attributable to Ionising Radiation; Annex B: Quantities used in Radiological

  5. The Universal Recommender

    CERN Document Server

    Kunegis, Jérôme; Umbrath, Winfried

    2009-01-01

    We describe the Universal Recommender, a recommender system for semantic datasets that generalizes domain-specific recommenders such a content-based, collaborative, social, bibliographic, lexicographic, hybrid and other recommenders. In contrast to existing recommender systems, the Universal Recommender applies to any dataset that allows a semantic representation. We describe the scalable three-stage architecture of the Universal Recommender and its application to Internet Protocol Television (IPTV). To achieve good recommendation accuracy, several novel machine learning and optimization problems are identified. We finally give a brief argument supporting the need for machine learning recommenders.

  6. On Imprecise Investment Recommendations

    Directory of Open Access Journals (Sweden)

    Piasecki Krzysztof

    2014-08-01

    Full Text Available The return rate is considered here as a fuzzy probabilistic set. Then the expected return is obtained as a fuzzy subset in the real line. This result is a theoretical foundation for new investment strategies. All considered strategies result of comparison profit fuzzy index and limit value. In this way we obtain an imprecise investment recommendation. Financial equilibrium criteria are a special case of comparison of the profit index and the limit value. The following criteria are generalized here: the Sharpe's Ratio, the Jensen's Alpha and the Treynor's Ratio. Moreover, the safety-first criteria are generalized here for the fuzzy case. The Roy Criterion, the Kataoka Criterion and the Telser Criterion are also generalized. Obtained results show that proposed theory is useful for the investment applications.

  7. Analytical studies by activation. Part A and B: Counting of short half-life radio-nuclides. Part C: Analytical programs for decay curves; Etudes d'analyse par activation. Parties A et B: le comptage des radio-nucleides de periodes courtes. Partie C: programme de depouillement des courbes de decroissance

    Energy Technology Data Exchange (ETDEWEB)

    Junod, E. [Commissariat a l' Energie Atomique Grenoble (France). Centre d' Etudes Nucleaires

    1966-03-01

    Part A and B: Since a radio-nuclide of short half-life is characterized essentially by the decrease in its activity even while it is being measured, the report begins by recalling the basic relationships linking the half-life the counting time, the counting rate and the number of particles recorded. The second part is devoted to the problem of corrections for counting losses due to the idle period of multichannel analyzers. Exact correction formulae have been drawn up for the case where the short half-life radionuclide is pure or contains only a long half-life radio-nuclide. By comparison, charts have been drawn up showing the approximations given by the so-called 'active time' counting and by the counting involving the real time associated with a measurement of the overall idle period, this latter method proving to be more valid than the former. A method is given for reducing the case of a complex mixture to that of a two-component mixture. Part C: The problems connected with the qualitative and quantitative analysis of the decay curves of a mixture of radioactive sources of which one at least has a short half-life are presented. A mathematical description is given of six basic processes for which some elements of Fortran programs are proposed. Two supplementary programs are drawn up for giving an overall treatment of problems of dosage in activation analysis: one on the basis of a simultaneous irradiation of the sample and of one or several known samples, the other with separate irradiation of the unknown and known samples, a dosimeter (activation, or external) being used for normalizing the irradiation flux conditions. (author) [French] Parties A et B: Un radionucleide de periode courte etant defini specialement par la decroissance de son activite pendant la duree meme du comptage, on rappelle en premiere partie de ce rapport les relations fondamentales qui lient periode, temps de comptage, taux de comptage et nombre d'impulsions enregistrees. La

  8. An absolute determination of the 14O ( β+) Fermi decay Q-value

    Science.gov (United States)

    White, R. E.; Naylor, H.; Barker, P. H.; Lovelock, D. M. J.; Smythe, R. M.

    1981-10-01

    The threshold energy for the reaction 14N(p, n) 14O has been determined to be 6353.02±0.08keV, yielding a corresponding energy release of 1808.25±0.10keV for the superallowed 14O decay. Using recent half-life values an ƒ Rt- value of 3084.4±1.1 s. is obtained for this decay.

  9. Quantum Yields of Decomposition and Homo-Dimerization of Solid L-Alanine Induced by 7.2 eV Vacuum Ultraviolet Light Irradiation: An Estimate of the Half-Life of L-Alanine on the Surface of Space Objects

    Science.gov (United States)

    Izumi, Yudai; Nakagawa, Kazumichi

    2011-08-01

    One of the leading hypotheses regarding the origin of prebiotic molecules on primitive Earth is that they formed from inorganic molecules in extraterrestrial environments and were delivered by meteorites, space dust and comets. To evaluate the availability of extraterrestrial amino acids, it is necessary to examine their decomposition and oligomerization rates as induced by extraterrestrial energy sources, such as vacuum ultraviolet (VUV) and X-ray photons and high energy particles. This paper reports the quantum yields of decomposition ((8.2 ± 0.7) × 10-2 photon-1) and homo-dimerization ((1.2 ± 0.3) × 10-3 photon-1) and decomposition of the dimer (0.24 ± 0.06 photon-1) of solid l-alanine (Ala) induced by VUV light with an energy of 7.2 eV. Using these quantum yields, the half-life of l-Ala on the surface of a space object in the present earth orbit was estimated to be about 52 days, even when only photons with an energy of 7.2 eV emitted from the present Sun were considered. The actual half-life of solid l-Ala on the surface of a space object orbit around the present day Earth would certainly be much shorter than our estimate, because of the added effect of photons and particles of other energies. Thus, we propose that l-Ala needs to be shielded from solar VUV in protected environments, such as the interior of a meteorite, within a time scale of days after synthesis to ensure its arrival on the primitive Earth.

  10. OARSI Clinical Trials Recommendations

    DEFF Research Database (Denmark)

    McAlindon, T. E.; Driban, J. B.; Henrotin, Y.;

    2015-01-01

    The goal of this document is to update the original OARSI recommendations specifically for the design, conduct, and reporting of clinical trials that target symptom or structure modification among individuals with knee osteoarthritis (OA). To develop recommendations for the design, conduct...... and index knee, describing interventions, patient-reported and physical performance measures, structural outcome measures, biochemical biomarkers, and reporting recommendations. In summary, the working group identified 25 recommendations that represent the current best practices regarding clinical trials...... that target symptom or structure modification among individuals with knee OA. These updated recommendations incorporate novel technologies (e.g., magnetic resonance imaging (MRI)) and strategies to address the heterogeneity of knee OA....

  11. Trust for intelligent recommendation

    CERN Document Server

    Bhuiyan, Touhid

    2013-01-01

    Recommender systems are one of the recent inventions to deal with the ever-growing information overload in relation to the selection of goods and services in a global economy. Collaborative Filtering (CF) is one of the most popular techniques in recommender systems. The CF recommends items to a target user based on the preferences of a set of similar users known as the neighbors, generated from a database made up of the preferences of past users. In the absence of these ratings, trust between the users could be used to choose the neighbor for recommendation making. Better recommendations can b

  12. What Is the Half-Life of Basketball Teams?

    Science.gov (United States)

    Hrepic, Zdeslav

    2013-01-01

    What do basketball teams have in common with radioactive nuclei? It turns out, there is more here than first meets the eye. The National Collegiate Athletic Association (NCAA) basketball tournaments feeds fans' craving when NBA competitions are not in swing, and the college tournament time has been referred to as "March Madness" or…

  13. Using an Authentic Radioisotope to Teach Half-Life

    Science.gov (United States)

    Liddicoat, Scott; Sebranek, John

    2005-01-01

    Traditionally nuclear chemistry appears in the last few chapters of chemistry textbooks and is not normally considered a mainstream topic. In addition, some science teachers lack the training or equipment to teach nuclear chemistry. Yet nuclear chemistry is a very important topic that should be taught in all chemistry classrooms. Learning about…

  14. Half Life - The divided life of Bruno Maximovitch Pontecorvo

    CERN Document Server

    CERN. Geneva

    2016-01-01

    When Bruno Pontecorvo fled to the USSR at the height of the Cold War in 1950, half way through his life, the British Government, MI5 and FBI tried to portray him as scientifically insignificant, and to imply that his disappearance posed no threat to the West. In reality Pontecorvo was already one of the leading experts in nuclear physics, and recently declassified papers reveal that a prime agenda of FBI and MI5 was to cover up their errors. . During his time in the USSR he made major contributions to physics, and justified the sobriquet: "Mr Neutrino". This talk will reveal the background to his sudden flight, and also evaluate his work in theoretical physics in the aftermath of his arrival in Dubna. Previously secret documents now show that he proposed the concept of associated production before Gell Mann and Pais, and he had an idea to discover the neutrino at a reactor. He may be considered the father of neutrino astronomy with his successful prediction that neutrinos from a supernova could be detected, b...

  15. What Is the Half-Life of Basketball Teams?

    Science.gov (United States)

    Hrepic, Zdeslav

    2013-01-01

    What do basketball teams have in common with radioactive nuclei? It turns out, there is more here than first meets the eye. The National Collegiate Athletic Association (NCAA) basketball tournaments feeds fans' craving when NBA competitions are not in swing, and the college tournament time has been referred to as "March Madness" or…

  16. Cosmic-ray half-life of {sup 144}Pm

    Energy Technology Data Exchange (ETDEWEB)

    Zaerpoor, K.; Dragowsky, M.R.; Krane, K.S. [Physics Department, Oregon State University, Corvallis, Oregon97331 (United States); Chan, Y.D.; Isaac, M.C.; Larimer, R.M.; Macchiavelli, A.O.; Macleod, R.W.; Norman, E.B. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, California94720 (United States); DiGregorio, D.E. [Laboratorio TANDAR-CNEA, Buenos Aires, 1429 (Argentina); Hindi, M.M.; Robinson, S.J. [Physics Department, Tennessee Technological University, Cookeville, Tennessee38505 (United States); Miocinovic, P. [Physics Department, University of California, Berkeley, California94720 (United States)

    1998-04-01

    In order to test the possibility of using {sup 144}Pm as a clock to measure the mean cosmic-ray confinement time in the Galaxy, we counted a highly purified 1.4 {mu}Ci source of this isotope in GAMMASPHERE and searched for its astrophysically interesting {beta}{sup +} decay branch through the observation of positron-annihilation {gamma} rays in coincidence with the characteristic 697-keV {gamma} ray. Analysis of 57 h of source counting and 15 h of background shows no net signal and results in an upper limit of 3.7 of 511-511-697 keV coincident events. From this result we establish a 90{percent} confidence level upper limit on the branch for this decay mode to be 7.4{times}10{sup {minus}6}{percent}. The implications of this result for the {sup 144}Pm cosmic-ray chronometer problem are discussed. {copyright} {ital 1998} {ital The American Physical Society}

  17. The Definition of Novelty in Recommendation System

    Directory of Open Access Journals (Sweden)

    Liang Zhang

    2013-01-01

    Full Text Available With the development of information technology and application of the Internet, People gradually entered the time of information overload from information scarcity. User satisfaction with recommender systems is related not only to how accurately the system recommends but also to how much it supports the user’s decision making. Novelty is one of the important metrics of customer satisfaction. There is an increasing realization in the Recommender Systems (RS field that novelty is fundamental qualities of recommendation effectiveness and added-value. This paper combed research results about definition and algorithm of novel recommendation, and starting from the meaning of "novel", defined novelty of item in recommendation system. Experiment proved using the definition of novelty to recommend can effectively recognize the item that the user is familiar with and ensure certain accuracy.

  18. Juvenile Spondyloarthritis Treatment Recommendations

    OpenAIRE

    Tse, Shirley; Burgos-Vargas, Ruben; Colbert, Robert A

    2012-01-01

    No specific recommendations for the treatment of juvenile spondyloarthritis have been established. Important differences exist in how spondyloarthritis begins and progresses in children and adults, supporting the need for pediatric-specific recommendations. Recently published recommendations for the treatment of juvenile arthritis consider children with sacroiliitis in a separate group, and allow for more accelerated institution of a TNF inhibitor depending on disease activity and prognostic ...

  19. Efficiently Computing Private Recommendations

    NARCIS (Netherlands)

    Erkin, Z.; Beye, M.; Veugen, P.J.M.; Lagendijk, R.L.

    2011-01-01

    Online recommender systems enable personalized service to users. The underlying collaborative filtering techniques operate on privacy sensitive user data, which could be misused by the service provider. To protect user privacy, we propose to encrypt the data and generate recommendations by processin

  20. Efficiently computing private recommendations

    NARCIS (Netherlands)

    Erkin, Z.; Beye, M.; Veugen, T.; Lagendijk, R.L.

    2011-01-01

    Online recommender systems enable personalized service to users. The underlying collaborative filtering techniques operate on privacy sensitive user data, which could be misused by the service provider. To protect user privacy, we propose to encrypt the data and generate recommendations by processin

  1. Search and Recommendation

    DEFF Research Database (Denmark)

    Bogers, Toine

    2014-01-01

    -scale application by companies like Amazon, Facebook, and Netflix. But are search and recommendation really two different fields of research that address different problems with different sets of algorithms in papers published at distinct conferences? In my talk, I want to argue that search and recommendation...

  2. Development of controller of acquisition and sample positioner for activation for use in measurements of short half-life radioisotopes; Desenvolvimento de dispositivo movimentador automatizado de amostras com vista a aplicacao em medidas de radioisotopos que possuem curto tempo de meia-vida

    Energy Technology Data Exchange (ETDEWEB)

    Secco, Marcello

    2016-08-01

    High resolution gamma spectroscopy measurements have several applications. Those involving short half-life radioisotope measurements may present low precision problems when the radioactive source is far from detector end cup and in the very high activity situations also can present accuracy loss due to dead time and pile-up effects. A way to overcome these problems is changing the source detector distance as the activity is decreasing, and thereby maximizing the statistical counting. In the present study, the Controller of Acquisition and Sample Positioner for Activation (CASPA) was developed. It is a low cost and weight device, made with low atomic number materials designed to assist gamma spectroscopy measurements, which is able to control the distance between the source and the detector, even allowing that there is a change of this distance during the measurement process. Because it is automated it optimizes the time of the operator, who has complete freedom to program their routine measurements in the device besides minimizing the radiation dose in the operator. An interface that allow the user control the CASPA system and to program the acquisition system was created. Tests aiming to optimize the operation of CASPA system were carried out and the safety of the CASPA operation was verified, it was not presented any failure during their tests. It was applied the repeatability tests by the acquisition {sup 60}Co standard source and was found that the positioning of automated system has reproduced the results of static system with a 95% of confidence level. (author)

  3. Recommender Systems for Learning

    CERN Document Server

    Manouselis, Nikos; Verbert, Katrien; Duval, Erik

    2013-01-01

    Technology enhanced learning (TEL) aims to design, develop and test sociotechnical innovations that will support and enhance learning practices of both individuals and organisations. It is therefore an application domain that generally covers technologies that support all forms of teaching and learning activities. Since information retrieval (in terms of searching for relevant learning resources to support teachers or learners) is a pivotal activity in TEL, the deployment of recommender systems has attracted increased interest. This brief attempts to provide an introduction to recommender systems for TEL settings, as well as to highlight their particularities compared to recommender systems for other application domains.

  4. Management recommendations: Tewaukon Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a review of land management practices at the Tewaukon Complex, by a land use specialist. Recommendations, time frame and additional comments are...

  5. Recommended Textbooks (Booksearch).

    Science.gov (United States)

    English Journal, 1988

    1988-01-01

    Evaluates four textbooks recommended by junior high and high school teachers for teaching writing and literature: "Enjoying Literature" (published by Macmillan, 1985); "Exposition: Critical Writing and Thinking" (Robert J. Gula); "Situational Writing" (Gene Krupa); and "Double Exposure: Composing through Writing…

  6. Management recommendations: Kirwin Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a review of land management practices at the Kirwin National Wildlife Refuge, by a land use specialist. Recommendations, time frame and additional...

  7. Probabilistic approaches to recommendations

    CERN Document Server

    Barbieri, Nicola; Ritacco, Ettore

    2014-01-01

    The importance of accurate recommender systems has been widely recognized by academia and industry, and recommendation is rapidly becoming one of the most successful applications of data mining and machine learning. Understanding and predicting the choices and preferences of users is a challenging task: real-world scenarios involve users behaving in complex situations, where prior beliefs, specific tendencies, and reciprocal influences jointly contribute to determining the preferences of users toward huge amounts of information, services, and products. Probabilistic modeling represents a robus

  8. New Insulin Delivery Recommendations.

    Science.gov (United States)

    Frid, Anders H; Kreugel, Gillian; Grassi, Giorgio; Halimi, Serge; Hicks, Debbie; Hirsch, Laurence J; Smith, Mike J; Wellhoener, Regine; Bode, Bruce W; Hirsch, Irl B; Kalra, Sanjay; Ji, Linong; Strauss, Kenneth W

    2016-09-01

    Many primary care professionals manage injection or infusion therapies in patients with diabetes. Few published guidelines have been available to help such professionals and their patients manage these therapies. Herein, we present new, practical, and comprehensive recommendations for diabetes injections and infusions. These recommendations were informed by a large international survey of current practice and were written and vetted by 183 diabetes experts from 54 countries at the Forum for Injection Technique and Therapy: Expert Recommendations (FITTER) workshop held in Rome, Italy, in 2015. Recommendations are organized around the themes of anatomy, physiology, pathology, psychology, and technology. Key among the recommendations are that the shortest needles (currently the 4-mm pen and 6-mm syringe needles) are safe, effective, and less painful and should be the first-line choice in all patient categories; intramuscular injections should be avoided, especially with long-acting insulins, because severe hypoglycemia may result; lipohypertrophy is a frequent complication of therapy that distorts insulin absorption, and, therefore, injections and infusions should not be given into these lesions and correct site rotation will help prevent them; effective long-term therapy with insulin is critically dependent on addressing psychological hurdles upstream, even before insulin has been started; inappropriate disposal of used sharps poses a risk of infection with blood-borne pathogens; and mitigation is possible with proper training, effective disposal strategies, and the use of safety devices. Adherence to these new recommendations should lead to more effective therapies, improved outcomes, and lower costs for patients with diabetes.

  9. 顶级券商的明星分析师荐股评级更有价值么?——基于券商声誉、分析师声誉的实证研究%Do Star Analysts' Recommendations from Top Brokers have more Investment Value?An Empirical Study Based on Reputation

    Institute of Scientific and Technical Information of China (English)

    王宇熹; 洪剑峭; 肖峻

    2012-01-01

    利用2003-2009年《新财富》杂志评选作为分析师声誉和券商声誉代理变量,结合超过54000条分析师推荐评级样本,从投资者角度检验了券商声誉、分析师声誉与分析师荐股评级价值之间的短期关系和长期关系,研究结果发现:在评级公告日,“买入/增持”,“中性”,“减持/卖出”评级分组的超常收益率与分析师声誉和券商声誉之间存在不同的影响规律.通过长期关系检验还发现牛市阶段,非顶级券商明星分析师“买入/增持”评级的投资价值高于顶级券商明星分析师,但在熊市阶段,非顶级券商非明星分析师“买入/增持”评级投资价值最高,顶级券商明星分析师投资价值最低.顶级券商和非顶级券商的明星分析师“中性”评级投资价值低,投资者容易错失投资机会.顶级券商明星分析师“减持/卖出”评级投资价值最高;非顶级券商明星分析师“减持/卖出”评级投资价值最低.最后提出了维护分析师证券研究报告独立性的四条政策建议.%Using the New Fortune Magazine's star analysts ranking as the agent of reputation, combined with analysts' stock rating samples exceeding 54000, this paper tests short-term and long-term relationship between analyst reputation and the investment value of the recommendation. The results show that the investment value from different groups of recommendation samples take on different correlation with brokers' reputation and analysts' reputation. In the first part, the short-term model examines the relationship between analyst recommendation performance and reputation. Market-adjusted return of recommended stock on the announcement day is adopted as the agent of analyst' s recommendation performance to regress on specific explanatory and control variables. If more than one analyst recommendation on a particular stock, then this stock will appear multiple times in the regression, once for each

  10. Distributed Deliberative Recommender Systems

    Science.gov (United States)

    Recio-García, Juan A.; Díaz-Agudo, Belén; González-Sanz, Sergio; Sanchez, Lara Quijano

    Case-Based Reasoning (CBR) is one of most successful applied AI technologies of recent years. Although many CBR systems reason locally on a previous experience base to solve new problems, in this paper we focus on distributed retrieval processes working on a network of collaborating CBR systems. In such systems, each node in a network of CBR agents collaborates, arguments and counterarguments its local results with other nodes to improve the performance of the system's global response. We describe D2ISCO: a framework to design and implement deliberative and collaborative CBR systems that is integrated as a part of jcolibritwo an established framework in the CBR community. We apply D2ISCO to one particular simplified type of CBR systems: recommender systems. We perform a first case study for a collaborative music recommender system and present the results of an experiment of the accuracy of the system results using a fuzzy version of the argumentation system AMAL and a network topology based on a social network. Besides individual recommendation we also discuss how D2ISCO can be used to improve recommendations to groups and we present a second case of study based on the movie recommendation domain with heterogeneous groups according to the group personality composition and a group topology based on a social network.

  11. The Value of Value

    DEFF Research Database (Denmark)

    Sørensen, Asger

    parts of business ethics given prominence to especially one term, namely `value'. The question that interests me is the following: What does the articulation of ethics and morality in terms of values mean for ethics and morality as such. Or, to put the question in a more fashionably way: What...... is the value of value for morality and ethics?To make things a bit more precise, we can make use of the common distinction between ethics and morality, i.e. that morality is the immediate, collective and unconscious employment of morals, whereas ethics is the systematic, individual and conscious reflections...

  12. Order Theoretical Semantic Recommendation

    Energy Technology Data Exchange (ETDEWEB)

    Joslyn, Cliff A.; Hogan, Emilie A.; Paulson, Patrick R.; Peterson, Elena S.; Stephan, Eric G.; Thomas, Dennis G.

    2013-07-23

    Mathematical concepts of order and ordering relations play multiple roles in semantic technologies. Discrete totally ordered data characterize both input streams and top-k rank-ordered recommendations and query output, while temporal attributes establish numerical total orders, either over time points or in the more complex case of startend temporal intervals. But also of note are the fully partially ordered data, including both lattices and non-lattices, which actually dominate the semantic strcuture of ontological systems. Scalar semantic similarities over partially-ordered semantic data are traditionally used to return rank-ordered recommendations, but these require complementation with true metrics available over partially ordered sets. In this paper we report on our work in the foundations of partial order measurement in ontologies, with application to top-k semantic recommendation in workflows.

  13. Archetypal Game Recommender Systems

    DEFF Research Database (Denmark)

    Sifa, Rafet; Bauckhage, C.; Drachen, Anders

    2014-01-01

    feedback are presented: factor- and neighborhood-oriented models. These form the rst application of rec- ommender systems to digital games. Both models are tested on a dataset of 500,000 users of the game distribution platform Steam, covering game ownership and playtime data across more than 3000 games....... Compared to four other recommender models (nearest neighbor, two popularity mod- els, random baseline), the archetype based models provide the highest recall rates showing that Archetypal Analysis can be successfully applied for Top-L recommendation purposes...

  14. Adding value(s)

    DEFF Research Database (Denmark)

    Carré, David

    2015-01-01

    , 1992). In response, behavioral economics (Camerer, 1999) has shown that agents have values other than optimization underpinning their decisions. Therefore, concerns arose regarding which values are guiding the agent but not about how such values became relevant for the agent. In this presentation, I......Most economic inquires revolve around agents making decisions. Getting the ‘best value’, it is assumed, drives such decisions: gaining most while risking least. This assumption has been debunked by showing that people does not always choose neither maximum benefit nor less risk (Kahneman & Tversky...... will explore the consequences of shifting to the latter perspective, i.e. looking for the generative framework of values. Here I argue that economic behavior should also be seen as a sense-making process, guided by values that are chosen/rejected along with fellow human beings, in specific socio...

  15. Towards Geosocial Recommender Systems

    NARCIS (Netherlands)

    Graaff, de Victor; Keulen, van Maurice; By, de Rolf A.

    2012-01-01

    The usage of social networks sites (SNSs), such as Facebook, and geosocial networks (GSNs), such as Foursquare, has increased tremendously over the past years. The willingness of users to share their current locations and experiences facilitate the creation of geographical recommender systems based

  16. OARSI Clinical Trials Recommendations

    DEFF Research Database (Denmark)

    Emery, C. A.; Roos, Ewa M.; Verhagen, E.;

    2015-01-01

    The risk of post-traumatic osteoarthritis (PTOA) substantially increases following joint injury. Research efforts should focus on investigating the efficacy of preventative strategies in high quality randomized controlled trials (RCT). The objective of these OARSI RCT recommendations is to inform...

  17. ICRS Recommendation Document

    DEFF Research Database (Denmark)

    Roos, Ewa M.; Engelhart, Luella; Ranstam, Jonas

    2011-01-01

    Abstract Objective: The purpose of this article is to describe and recommend patient-reported outcome instruments for use in patients with articular cartilage lesions undergoing cartilage repair interventions. Methods: Nonsystematic literature search identifying measures addressing pain and funct......Abstract Objective: The purpose of this article is to describe and recommend patient-reported outcome instruments for use in patients with articular cartilage lesions undergoing cartilage repair interventions. Methods: Nonsystematic literature search identifying measures addressing pain...... constructs at all levels according to the International Classification of Functioning. Conclusions: Because there is no obvious superiority of either instrument at this time, both outcome measures are recommended for use in cartilage repair. Rescaling of the Lysholm Scoring Scale has been suggested......, and confirmatory longitudinal studies are needed prior to recommending this scale for use in cartilage repair. Inclusion of a generic measure is feasible in cartilage repair studies and allows analysis of health-related quality of life and health economic outcomes. The Marx or Tegner Activity Rating Scales...

  18. Privacy in recommender systems

    NARCIS (Netherlands)

    Jeckmans, Arjan; Beye, Michael; Erkin, Zekeriya; Hartel, Pieter; Lagendijk, Reginald; Tang, Qiang; Ramzan, Naeem; Zwol, van Roelof; Lee, Jong-Seok; Clüver, Kai; Hua, Xian-Sheng

    2013-01-01

    In many online applications, the range of content that is offered to users is so wide that a need for automated recommender systems arises. Such systems can provide a personalized selection of relevant items to users. In practice, this can help people find entertaining movies, boost sales through ta

  19. Value Chain Engineering

    DEFF Research Database (Denmark)

    Wæhrens, Brian Vejrum; Slepniov, Dmitrij

    2015-01-01

    This workbook is recommended for the attention of students of and managers in Danish small and medium sized enterprises (SMEs). Danish SMEs are currently facing a number of key challenges related to their position in global value chains. This book provides an insight into value chain management t...

  20. Rheumatologic rehabilitation: towards recommendations

    Directory of Open Access Journals (Sweden)

    S. Maddali Bongi

    2014-11-01

    Full Text Available Rheumatic patients are highly complex and often affected by chronic diseases. Rehabilitation is generally needed for proper management of the underlying disease. This article describes the characteristics of an effective rheumatologic rehabilitation, takes into account data published in international literature, suggests recommendations based on scientific evidence to develop a correct rehabilitation plan for rheumatic patients and proposes the basis to draw up guidelines in the field of rheumatologic rehabilitation.

  1. Recommending Given Names

    CERN Document Server

    Mitzlaff, Folke

    2013-01-01

    All over the world, future parents are facing the task of finding a suitable given name for their child. This choice is influenced by different factors, such as the social context, language, cultural background and especially personal taste. Although this task is omnipresent, little research has been conducted on the analysis and application of interrelations among given names from a data mining perspective. The present work tackles the problem of recommending given names, by firstly mining for inter-name relatedness in data from the Social Web. Based on these results, the name search engine "Nameling" was built, which attracted more than 35,000 users within less than six months, underpinning the relevance of the underlying recommendation task. The accruing usage data is then used for evaluating different state-of-the-art recommendation systems, as well our new \\NR algorithm which we adopted from our previous work on folksonomies and which yields the best results, considering the trade-off between prediction ...

  2. RECOMMENDED TRITIUM OXIDE DEPOSITION VELOCITY FOR USE IN SAVANNAH RIVER SITE SAFETY ANALYSES

    Energy Technology Data Exchange (ETDEWEB)

    Lee, P.; Murphy, C.; Viner, B.; Hunter, C.; Jannik, T.

    2012-04-03

    The Defense Nuclear Facilities Safety Board (DNFSB) has recently questioned the appropriate value for tritium deposition velocity used in the MELCOR Accident Consequence Code System Ver. 2 (Chanin and Young 1998) code when estimating bounding dose (95th percentile) for safety analysis (DNFSB 2011). The purpose of this paper is to provide appropriate, defensible values of the tritium deposition velocity for use in Savannah River Site (SRS) safety analyses. To accomplish this, consideration must be given to the re-emission of tritium after deposition. Approximately 85% of the surface area of the SRS is forested. The majority of the forests are pine plantations, 68%. The remaining forest area is 6% mixed pine and hardwood and 26% swamp hardwood. Most of the path from potential release points to the site boundary is through forested land. A search of published studies indicate daylight, tritiated water (HTO) vapor deposition velocities in forest vegetation can range from 0.07 to 2.8 cm/s. Analysis of the results of studies done on an SRS pine plantation and climatological data from the SRS meteorological network indicate that the average deposition velocity during daylight periods is around 0.42 cm/s. The minimum deposition velocity was determined to be about 0.1 cm/s, which is the recommended bounding value. Deposition velocity and residence time (half-life) of HTO in vegetation are related by the leaf area and leaf water volume in the forest. For the characteristics of the pine plantation at SRS the residence time corresponding to the average, daylight deposition velocity is 0.4 hours. The residence time corresponding to the night-time deposition velocity of 0.1 cm/s is around 2 hours. A simple dispersion model which accounts for deposition and re-emission of HTO vapor was used to evaluate the impact on exposure to the maximally exposed offsite individual (MOI) at the SRS boundary (Viner 2012). Under conditions that produce the bounding, 95th percentile MOI exposure

  3. Estimating Probabilities in Recommendation Systems

    CERN Document Server

    Sun, Mingxuan; Kidwell, Paul

    2010-01-01

    Recommendation systems are emerging as an important business application with significant economic impact. Currently popular systems include Amazon's book recommendations, Netflix's movie recommendations, and Pandora's music recommendations. In this paper we address the problem of estimating probabilities associated with recommendation system data using non-parametric kernel smoothing. In our estimation we interpret missing items as randomly censored observations and obtain efficient computation schemes using combinatorial properties of generating functions. We demonstrate our approach with several case studies involving real world movie recommendation data. The results are comparable with state-of-the-art techniques while also providing probabilistic preference estimates outside the scope of traditional recommender systems.

  4. Personalized professional content recommendation

    Science.gov (United States)

    Xu, Songhua

    2015-10-27

    A personalized content recommendation system includes a client interface configured to automatically monitor a user's information data stream transmitted on the Internet. A hybrid contextual behavioral and collaborative personal interest inference engine resident to a non-transient media generates automatic predictions about the interests of individual users of the system. A database server retains the user's personal interest profile based on a plurality of monitored information. The system also includes a server programmed to filter items in an incoming information stream with the personal interest profile and is further programmed to identify only those items of the incoming information stream that substantially match the personal interest profile.

  5. Clinical Recommendation: Vulvovaginitis.

    Science.gov (United States)

    Zuckerman, Andrea; Romano, Mary

    2016-12-01

    Vulvovaginitis is a commonly encountered condition among prepubertal and adolescent females. The objective of this report is to provide the latest evidence regarding the diagnosis and management of vulvovaginitis in prepubertal and adolescent females. In this systematic review we used the Grading of Recommendations Assessment, Development and Evaluation evidence system. Vulvovaginal complaints are common in the pediatric and adolescent age group. The patient's age in conjunction with history and associated complaints will guide evaluation, diagnosis, and treatment. Treatment should include counseling on hygiene and voiding techniques as well as therapy for any specific pathogens identified.

  6. Archetypal Game Recommender Systems

    DEFF Research Database (Denmark)

    Sifa, Rafet; Bauckhage, C.; Drachen, Anders

    2014-01-01

    Contemporary users (players, consumers) of digital games have thousands of products to choose from, which makes nding games that t their interests challenging. Towards addressing this challenge, in this paper two dierent formulations of Archetypal Analysis for Top-L recommender tasks using implicit...... feedback are presented: factor- and neighborhood-oriented models. These form the rst application of rec- ommender systems to digital games. Both models are tested on a dataset of 500,000 users of the game distribution platform Steam, covering game ownership and playtime data across more than 3000 games...

  7. Mining and representing recommendations in actively evolving recommender systems

    DEFF Research Database (Denmark)

    Assent, Ira

    2010-01-01

    ) recommender connections. In this work, we propose mining such active systems to generate easily understandable representations of the recommender network. Users may review these representations to provide active feedback. This approach further enhances the quality of recommendations, especially as topics......Recommender systems provide an automatic means of filtering out interesting items, usually based on past similarity of user ratings. In previous work, we have suggested a model that allows users to actively build a recommender network. Users express trust, obtain transparency, and grow (anonymous...... of interest change over time. Most notably, it extends the amount of control users have over the model that the recommender network builds of their interests....

  8. Ebola virus: recommendations

    CERN Multimedia

    CERN Medical Service

    2014-01-01

    The CERN Medical Service has been closely following, in particular via the WHO, the development of the Ebola virus outbreak currently affecting some African countries. This infectious disease may be passed on through direct contact with the bodily fluids of a sick person.   Based on the recommendations of the WHO and the two Host States, Switzerland and France, as updated on their respective websites, so far there has been no ban on travel to the countries concerned. However, unless it is absolutely essential, you are advised not to visit any of the countries affected by Ebola (Guinea, Republic of Sierra Leone, Liberia, Nigeria). The two Host States have established an alert system, and a check is carried out on departure from the airports of those countries. It is strongly recommended that you contact the Medical Service if you are travelling to those countries. We remind you to observe the basic rules of hygiene such as frequent hand washing, whatever your destination. The Medical Service is...

  9. Secondary prophylaxis with rFVIIa in hemophilia and inhibitors: Recommendations from an Experts Committee from Argentina

    Directory of Open Access Journals (Sweden)

    Raúl Pérez Bianco

    2010-06-01

    Full Text Available Secondary prophylaxis with rFVIIa has been the subject of several publications in the past few years. However, there is no general consensus on how this treatment should be put into practice, as publications have been very heterogeneous in the dosing schedule they report. Furthermore, the mechanism of action of rFVIIa and its short half life have been used as arguments against its role in prophylaxis. There have been a series of recent publications that show that rFVIIa can traffic through the intact endothelium and be stored in the subendothelium of several organs for a prolonged period of time. In order to consensuate the role of rFVIIa in prophylaxis, a group of experts from Argentina, resumed available information regarding pharmacology and clinical experience with this treatment, and developed a series of recommendations to use this drug in the prophylaxis setting.

  10. Maximizing profit using recommender systems

    CERN Document Server

    Das, Aparna; Ricketts, Daniel

    2009-01-01

    Traditional recommendation systems make recommendations based solely on the customer's past purchases, product ratings and demographic data without considering the profitability the items being recommended. In this work we study the question of how a vendor can directly incorporate the profitability of items into its recommender so as to maximize its expected profit while still providing accurate recommendations. Our approach uses the output of any traditional recommender system and adjust them according to item profitabilities. Our approach is parameterized so the vendor can control how much the recommendation incorporating profits can deviate from the traditional recommendation. We study our approach under two settings and show that it achieves approximately 22% more profit than traditional recommendations.

  11. Preventing Recommendation Attack in Trust-Based Recommender Systems

    Institute of Scientific and Technical Information of China (English)

    Fu-Guo Zhang

    2011-01-01

    Despite its success,similarity-based collaborative filtering suffers from some limitations,such as scalability,sparsity and recommendation attack.Prior work has shown incorporating trust mechanism into traditional collaborative filtering recommender systems can improve these limitations.We argue that trust-based recommender systems are facing novel recommendation attack which is different from the profile injection attacks in traditional recommender system.To the best of our knowledge,there has not any prior study on recommendation attack in a trust-based recommender system.We analyze the attack problem,and find that "victim" nodes play a significant role in the attack.Furthermore,we propose a data provenance method to trace malicious users and identify the "victim" nodes as distrust users of recommender system.Feasibility study of the defend method is done with the dataset crawled from Epinions website.

  12. Wind Farm Recommendation Report

    Energy Technology Data Exchange (ETDEWEB)

    John Reisenauer

    2011-05-01

    On April 21, 2011, an Idaho National Laboratory (INL) Land Use Committee meeting was convened to develop a wind farm recommendation for the Executive Council and a list of proposed actions for proceeding with the recommendation. In terms of land use, the INL Land Use Committee unanimously agrees that Site 6 is the preferred location of the alternatives presented for an INL wind farm. However, further studies and resolution to questions raised (stated in this report) by the INL Land Use Committee are needed for the preferred location. Studies include, but are not limited to, wind viability (6 months), bats (2 years), and the visual impact of the wind farm. In addition, cultural resource surveys and consultation (1 month) and the National Environmental Policy Act process (9 to 12 months) need to be completed. Furthermore, there is no documented evidence of developers expressing interest in constructing a small wind farm on INL, nor a specific list of expectations or concessions for which a developer might expect INL to cover the cost. To date, INL assumes the National Environmental Policy Act activities will be paid for by the Department of Energy and INL (the environmental assessment has only received partial funding). However, other concessions also may be expected by developers such as roads, fencing, power line installation, tie-ins to substations, annual maintenance, snow removal, access control, down-time, and remediation. These types of concessions have not been documented, as a request, from a developer and INL has not identified the short and long-term cost liabilities for such concessions should a developer expect INL to cover these costs. INL has not identified a go-no-go funding level or the priority this Wind Farm Project might have with respect to other nuclear-related projects, should the wind farm remain an unfunded mandate. The Land Use Committee recommends Legal be consulted to determine what, if any, liabilities exist with the Wind Farm Project and

  13. [GRADE guidelines 15: going from evidence to recommendation - determinants of a recommendation's direction and strength].

    Science.gov (United States)

    Nußbaumer, Barbara; Gartlehner, Gerald; Kien, Christina; Kaminski-Hartenthaler, Angela; Langer, Gero; Meerpohl, Joerg J; Schünemann, Holger J

    2014-01-01

    In the GRADE approach, the strength of a recommendation reflects the extent to which we can be confident that the composite desirable effects of a management strategy outweigh the composite undesirable effects. This article addresses GRADE's approach to determining the direction and strength of a recommendation. The GRADE describes the balance of desirable and undesirable outcomes of interest among alternative management strategies depending on four domains, namely estimates of effect for desirable and undesirable outcomes of interest, confidence in the estimates of effect, estimates of values and preferences, and resource use. Ultimately, guideline panels must use judgment in integrating these factors to make a strong or weak recommendation for or against an intervention.

  14. Recommendation Process in SR1 Web Document Recommender System

    OpenAIRE

    Munteanu, Dan

    2008-01-01

    This paper presents a recommender system for web documents (given as bookmarks). The system uses for classification a combination of content, event and collaborative filters and for recommendation a modified Pearson-r algorithm. The algorithm for recommendation is using not only the correlation between users but also the similarity between classes. Some experimental results that support this approach are also presented.

  15. Personalized professional content recommendation

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Songhua

    2015-10-27

    A personalized content recommendation system includes a client interface configured to automatically monitor a user's information data stream transmitted on the Internet. A hybrid contextual behavioral and collaborative personal interest inference engine resident to a non-transient media generates automatic predictions about the interests of individual users of the system. A database server retains the user's personal interest profile based on a plurality of monitored information. The system also includes a server programmed to filter items in an incoming information stream with the personal interest profile and is further programmed to identify only those items of the incoming information stream that substantially match the personal interest profile.

  16. "Highly recommended introduction"

    DEFF Research Database (Denmark)

    Christiansen, Ask Vest

    2009-01-01

    by detachment, normatively and morally. Besides researching the actual abuse, individually and in aggregate, they also study structural circumstances that promote the use of drugs in sports; besides evaluations of the efficacy of the anti-doping efforts, they consider the effects of various anti-doping schemes...... on the integrity and privacy of the athletes. Ask Vest Christiansen, himself an internationally renowned scholar in the field, has read a recent, thus detached, introduction to drug use in sports, An Introduction to Drugs in Sport: Addicted to Winning by Ivan Waddington and Andy Smith (Routledge). Christiansen...... finds much to appreciate in the book, and a couple of disconcerting mistakes and misjudgments notwithstanding, he recommends the book as a solid introduction to the problem of doping – knowledgeable, well written and easy to read....

  17. OARSI Clinical Trials Recommendations

    DEFF Research Database (Denmark)

    Kraus, V B; Blanco, F J; Englund, M

    2015-01-01

    The objective of this work was to describe requirements for inclusion of soluble biomarkers in osteoarthritis (OA) clinical trials and progress toward OA-related biomarker qualification. The Guidelines for Biomarkers Working Group, representing experts in the field of OA biomarker research from...... of reasons but in particular, to determine whether biomarkers are useful in identifying those individuals most likely to receive clinically important benefits from an intervention; and to determine whether biomarkers are useful for identifying individuals at earlier stages of OA in order to institute...... both academia and industry, convened to discuss issues related to soluble biomarkers and to make recommendations for their use in OA clinical trials based on current knowledge and anticipated benefits. This document summarizes current guidance on use of biomarkers in OA clinical trials...

  18. Recommendation in evolving online networks

    Science.gov (United States)

    Hu, Xiao; Zeng, An; Shang, Ming-Sheng

    2016-02-01

    Recommender system is an effective tool to find the most relevant information for online users. By analyzing the historical selection records of users, recommender system predicts the most likely future links in the user-item network and accordingly constructs a personalized recommendation list for each user. So far, the recommendation process is mostly investigated in static user-item networks. In this paper, we propose a model which allows us to examine the performance of the state-of-the-art recommendation algorithms in evolving networks. We find that the recommendation accuracy in general decreases with time if the evolution of the online network fully depends on the recommendation. Interestingly, some randomness in users' choice can significantly improve the long-term accuracy of the recommendation algorithm. When a hybrid recommendation algorithm is applied, we find that the optimal parameter gradually shifts towards the diversity-favoring recommendation algorithm, indicating that recommendation diversity is essential to keep a high long-term recommendation accuracy. Finally, we confirm our conclusions by studying the recommendation on networks with the real evolution data.

  19. Research of influential factors on elimination half life of vancomycin in children with severe pneumonia%万古霉素在重症肺炎患儿体内消除半衰期影响因素的研究

    Institute of Scientific and Technical Information of China (English)

    汪洋; 宋新文; 许琼; 张华年; 徐华

    2011-01-01

    目的:探讨万古霉素在重症肺炎患儿体内消除半衰期的影响因素.方法:测定29例重症肺炎患儿静滴万古霉素后在消除相两个时间点的血药浓度,并以此估算每位患儿万古霉素的消除半衰期t1/2(β).进一步利用SPSS 13.0软件作多元线性回归分析来考察t1/2(β)与患儿性别、年龄、身高、体质量、给药量及各生化指标之间的相关性.结果:万古霉素t1/2(β)与血清肌酐(CRE,X)及天门冬酸氨基转移酶(AST,Y)浓度呈正相关(P<0.05),与其他统计数据无显著相关性.回归方程为:t1/2(β)=0.360X+0.043Y-6.316(r=0.851,P<0.01).结论:万古霉素在重症肺炎患儿体内的消除速率与肝、肾功能密切相关,应监测血药浓度并根据患儿的自身状况来制订个体化给药方案.%OBJECTIVE To investigate the influential factors on elimination half life of vancomycin in children with severe pneumonia. METHODS The serum vancomycin concentrations at two time points on elimination phase after intravenous drip in each one of 29 children with severe pneumonia were determined, and which were used to calculate the elimination half lives of vancomycin (t1/2beta). The correlation between vancomycin t1/2beta and sex, age, body height, body weight and biochemical indexes of patients was analyzed with multiple linear regression method by SPSS (13. 0) software. RESULTS Vancomycin t1/2betawas positive correlated with serum creatinine concentration(CRE) and AST (P<0. 05), but no significant correlation was noted between t1/2beta and other statistical data. The regression equation was t1/2beta = 0. 360CRE + 0. 043AST - 6. 316(r = 0. 851, P>0. 000). CONCLUSION The elimination rate of vancomycin in children with severe pneumonia was closely correlated with liver and kidney functions, so it's necessary to monitor the serum vancomycin concentration and draw up individualized therapy according the body condition of every patient.

  20. National Recommended Water Quality Criteria

    Data.gov (United States)

    U.S. Environmental Protection Agency — The National Recommended Water Quality Criteria is a compilation of national recommended water quality criteria for the protection of aquatic life and human health...

  1. Classification of Recommender Expertise in the Wikipedia Recommender System

    DEFF Research Database (Denmark)

    Jensen, Christian D.; Pilkauskas, Povilas; Lefévre, Thomas

    2011-01-01

    feedback from recommenders that the user has agreed with in the past. This exposes the problem that most recommenders are not equally competent in all subject areas. The first WRS prototype did not include an evaluation of the areas of expertise of recommenders, so the trust metric used in the article...... ratings reflected the average competence of recommenders across all subject areas. We have now developed a new version of the WRS, which evaluates the expertise of recommenders within different subject areas. In order to do this, we need to identify a way to classify the subject area of all the articles...

  2. Urgent recommendation. Interim report

    Energy Technology Data Exchange (ETDEWEB)

    Nakano, Masayuki [International Affairs and Safeguards Division, Atomic Energy Bureau, Science and Technology Agency, Tokyo (Japan)

    2000-12-01

    The Investigation Committee for Critical Accident at Uranium Processing Plant was founded immediately after the accident to investigate the cause of the accident and to establish measures to prevent the similar accident. On September 30, 1999 around 10:35, the Japan's first criticality accident occurred at JCO Co. Ltd. Uranium processing plant (auxiliary conversion plant) located at Tokai-mura Ibaraki-ken. The criticality continued on and off for approximately 20 hours after the first instantaneous criticality. The accident led the recommendation of tentative evacuation and sheltering indoors for residents living in the neighborhood. The serious exposure to neutrons happened to three workers. The dominant effect is dose due to neutrons and gamma rays from the precipitation tank. When the accident took place, three workers dissolved sequentially about 2.4 kg uranium powder with 18.8 % enrichment in the 10-litter bucket with nitric acid. The procedure of homogenization of uranium nitrate was supposed to be controlled using the shape-limited narrow storage column. Actually, however, the thick and large precipitation tank was used. As a result, about 16.6 kg of uranium was fed into the tank, which presumably caused criticality. The first notification by JCO was delayed and the following communication was not smooth. This led to the delay of correct understanding of the situation and made the initial proper response difficult, then followed by insufficient communication between the nation, prefecture, and local authority. Urgent recommendations were made on the following items; (1) Safety measures to be taken at the accident site, (2) health cares for residents and others, (3) Comprehensive safety securing at nuclear operators such as Establishment of the effective audit system, Safety education for employees and Qualification and licensing system, Safety related documents, etc. (4) Reconstruction of the government's safety regulations such as How safety

  3. Algorithms for Academic Search and Recommendation Systems

    DEFF Research Database (Denmark)

    Amolochitis, Emmanouil

    2014-01-01

    In this work we present novel algorithms for academic search, recommendation and association rules mining. In the first part of the work we introduce a novel hierarchical heuristic scheme for re-ranking academic publications. The scheme is based on the hierarchical combination of a custom...... are part of a developed Movie Recommendation system, the first such system to be commercially deployed in Greece by a major Triple Play services provider. In the third part of the work we present the design of a quantitative association rule mining algorithm. The introduced mining algorithm processes...... a specific number of user histories in order to generate a set of association rules with a minimally required support and confidence value. We have introduced a post processor that uses the generated association rules and improves the quality (in terms of recall) of the original recommendation functionality....

  4. Do recommender systems benefit users?

    CERN Document Server

    Yeung, Chi Ho

    2015-01-01

    Recommender systems are present in many web applications to guide our choices. They increase sales and benefit sellers, but whether they benefit customers by providing relevant products is questionable. Here we introduce a model to examine the benefit of recommender systems for users, and found that recommendations from the system can be equivalent to random draws if one relies too strongly on the system. Nevertheless, with sufficient information about user preferences, recommendations become accurate and an abrupt transition to this accurate regime is observed for some algorithms. On the other hand, we found that a high accuracy evaluated by common accuracy metrics does not necessarily correspond to a high real accuracy nor a benefit for users, which serves as an alarm for operators and researchers of recommender systems. We tested our model with a real dataset and observed similar behaviors. Finally, a recommendation approach with improved accuracy is suggested. These results imply that recommender systems ...

  5. [Recommendations for neonatal transport].

    Science.gov (United States)

    Moreno Hernando, J; Thió Lluch, M; Salguero García, E; Rite Gracia, S; Fernández Lorenzo, J R; Echaniz Urcelay, I; Botet Mussons, F; Herranz Carrillo, G; Sánchez Luna, M

    2013-08-01

    During pregnancy, it is not always possible to identify maternal or foetal risk factors. Infants requiring specialised medical care are not always born in centres providing intensive care and will need to be transferred to a referral centre where intensive care can be provided. Therefore Neonatal Transport needs to be considered as part of the organisation of perinatal health care. The aim of Neonatal Transport is to transfer a newborn infant requiring intensive care to a centre where specialised resources and experience can be provided for the appropriate assessment and continuing treatment of a sick newborn infant. Intrauterine transfer is the ideal mode of transport when the birth of an infant with risk factors is diagnosed. Unfortunately, not all problems can be detected in advance with enough time to safely transfer a pregnant woman. Around 30- 50% of risk factors will be diagnosed during labour or soon after birth. Therefore, it is important to have the knowledge and resources to resuscitate and stabilise a newborn infant, as well as a specialised neonatal transport system. With this specialised transport it is possible to transfer newly born infants with the same level of care that they would receive if they had been born in a referral hospital, without increasing their risks or affecting the wellbeing of the newborn. The Standards Committee of the Spanish Society of Neonatology reviewed and updated recommendations for intrauterine transport and indications for neonatal transfer. They also reviewed organisational and logistic factors involved with performing neonatal transport. The Committee review included the type of personnel who should be involved; communication between referral and receiving hospitals; documentation; mode of transport; equipment to stabilise newly born infants; management during transfer, and admission at the referral hospital.

  6. Classification of Recommender Expertise in the Wikipedia Recommender System

    DEFF Research Database (Denmark)

    Jensen, Christian D.; Pilkauskas, Povilas; Lefevre, Thomas

    2011-01-01

    to the quality of articles. The Wikipedia Recommender System (WRS) was developed to help users determine the credibility of articles based on feedback from other Wikipedia users. The WRS implements a collaborative filtering system with trust metrics, i.e., it provides a rating of articles "which emphasizes...... feedback from recommenders that the user has agreed with in the past. This exposes the problem that most recommenders are not equally competent in all subject areas. The first WRS prototype did not include an evaluation of the areas of expertise of recommenders, so the trust metric used in the article...... ratings reflected the average competence of recommenders across all subject areas. We have now developed a new version of the WRS, which evaluates the expertise of recommenders within different subject areas. In order to do this, we need to identify a way to classify the subject area of all the articles...

  7. Recommendation Process in SR1 Web Document Recommender System

    Directory of Open Access Journals (Sweden)

    Dan MUNTEANU

    2008-12-01

    Full Text Available This paper presents a recommender system for web documents (given as bookmarks. The system uses for classification a combination of content, event and collaborative filters and for recommendation a modified Pearson-r algorithm. The algorithm for recommendation is using not only the correlation between users but also the similarity between classes. Some experimental results that support this approach are also presented.

  8. Economic assessment of nutritional recommendations.

    Science.gov (United States)

    Irz, Xavier; Leroy, Pascal; Réquillart, Vincent; Soler, Louis-Georges

    2015-01-01

    The effect of consumers' compliance with nutritional recommendations is uncertain because of potentially complex substitutions. To lift this uncertainty, we adapt a model of consumer behaviour under rationing to the case of linear nutritional constraints. Dietary adjustments are derived from information on consumer preferences, consumption levels, and nutritional contents of foods. A calibration exercise simulates, for different income groups, how the French diet would respond to various nutrition recommendations, and those behavioural adjustments are translated into health outcomes through the DIETRON epidemiological model. This allows for the ex-ante comparison of the efficiency, equity and health effects of ten nutritional recommendations. Although most recommendations impose significant taste costs on consumers, they are highly cost-effective, with the recommendations targeting salt, saturated fat, and fruits and vegetables (F&V) ranking highest in terms of efficiency. Most recommendations are also economically progressive, with the exception of that targeting F&V.

  9. Recommender systems in industrial contexts

    CERN Document Server

    Meyer, Frank

    2012-01-01

    This thesis consists of four parts: - An analysis of the core functions and the prerequisites for recommender systems in an industrial context: we identify four core functions for recommendation systems: Help do Decide, Help to Compare, Help to Explore, Help to Discover. The implementation of these functions has implications for the choices at the heart of algorithmic recommender systems. - A state of the art, which deals with the main techniques used in automated recommendation system: the two most commonly used algorithmic methods, the K-Nearest-Neighbor methods (KNN) and the fast factorization methods are detailed. The state of the art presents also purely content-based methods, hybridization techniques, and the classical performance metrics used to evaluate the recommender systems. This state of the art then gives an overview of several systems, both from academia and industry (Amazon, Google ...). - An analysis of the performances and implications of a recommendation system developed during this thesis: ...

  10. Recommendation systems in software engineering

    CERN Document Server

    Robillard, Martin P; Walker, Robert J; Zimmermann, Thomas

    2014-01-01

    With the growth of public and private data stores and the emergence of off-the-shelf data-mining technology, recommendation systems have emerged that specifically address the unique challenges of navigating and interpreting software engineering data.This book collects, structures and formalizes knowledge on recommendation systems in software engineering. It adopts a pragmatic approach with an explicit focus on system design, implementation, and evaluation. The book is divided into three parts: "Part I - Techniques" introduces basics for building recommenders in software engineering, including techniques for collecting and processing software engineering data, but also for presenting recommendations to users as part of their workflow.?"Part II - Evaluation" summarizes methods and experimental designs for evaluating recommendations in software engineering.?"Part III - Applications" describes needs, issues and solution concepts involved in entire recommendation systems for specific software engineering tasks, fo...

  11. Public Values

    DEFF Research Database (Denmark)

    Beck Jørgensen, Torben; Rutgers, Mark R.

    2015-01-01

    administration is approached in terms of processes guided or restricted by public values and as public value creating: public management and public policy-making are both concerned with establishing, following and realizing public values. To study public values a broad perspective is needed. The article suggest......This article provides the introduction to a symposium on contemporary public values research. It is argued that the contribution to this symposium represent a Public Values Perspective, distinct from other specific lines of research that also use public value as a core concept. Public...... a research agenda for this encompasing kind of public values research. Finally the contributions to the symposium are introduced....

  12. Recommendation Sets and Choice Queries

    DEFF Research Database (Denmark)

    Viappiani, Paolo Renato; Boutilier, Craig

    2011-01-01

    Utility elicitation is an important component of many applications, such as decision support systems and recommender systems. Such systems query users about their preferences and offer recommendations based on the system's belief about the user's utility function. We analyze the connection between...... the problem of generating optimal recommendation sets and the problem of generating optimal choice queries, considering both Bayesian and regret-based elicitation. Our results show that, somewhat surprisingly, under very general circumstances, the optimal recommendation set coincides with the optimal query....

  13. A fuzzy recommendation system for daily water intake

    Directory of Open Access Journals (Sweden)

    Bin Dai

    2016-05-01

    Full Text Available Water is one of the most important constituents of the human body. Daily consumption of water is thus necessary to protect human health. Daily water consumption is related to several factors such as age, ambient temperature, and degree of physical activity. These factors are generally difficult to express with exact numerical values. The main objective of this article is to build a daily water intake recommendation system using fuzzy methods. This system will use age, physical activity, and ambient temperature as the input factors and daily water intake values as the output factor. The reasoning mechanism of the fuzzy system can calculate the recommended value of daily water intake. Finally, the system will compare the actual recommended values with our system to determine the usefulness. The experimental results show that this recommendation system is effective in actual application.

  14. Feature Analysis of Recommender Techniques Employed in the Recommendation Engines

    Directory of Open Access Journals (Sweden)

    Gopinath Ganapathy

    2010-01-01

    Full Text Available Problem statement: Recommender Systems (RS have become a widely researched area as it is extensively used in web usage mining and E-commerce platforms. Approach: There were a number of recommender systems available to suggest the web pages for the web users. Results: A recommender system acted as an intelligent intermediary that automatically generates and predicts information and web pages, which suit the users’ behavior and users’ needs. Conclusion: The various recommender models and analyzing the key features of those models and analyzing the features of portal sites that employ recommender systems to help the research community are the key features of this study and survey.

  15. Context-Aware Recommender Systems

    Science.gov (United States)

    Adomavicius, Gediminas; Tuzhilin, Alexander

    The importance of contextual information has been recognized by researchers and practitioners in many disciplines, including e-commerce personalization, information retrieval, ubiquitous and mobile computing, data mining, marketing, and management. While a substantial amount of research has already been performed in the area of recommender systems, most existing approaches focus on recommending the most relevant items to users without taking into account any additional contextual information, such as time, location, or the company of other people (e.g., for watching movies or dining out). In this chapter we argue that relevant contextual information does matter in recommender systems and that it is important to take this information into account when providing recommendations. We discuss the general notion of context and how it can be modeled in recommender systems. Furthermore, we introduce three different algorithmic paradigms - contextual prefiltering, post-filtering, and modeling - for incorporating contextual information into the recommendation process, discuss the possibilities of combining several contextaware recommendation techniques into a single unifying approach, and provide a case study of one such combined approach. Finally, we present additional capabilities for context-aware recommenders and discuss important and promising directions for future research.

  16. From micronutrient recommendations to policy

    DEFF Research Database (Denmark)

    Timotijevic, Lada; Raats, Monique M.; Barnett, Julie

    2010-01-01

    Background/Objectives: To achieve the nutritional goals stipulated by micronutrient recommendations, greater attention must be paid to the behavioural routes to such nutritional outcomes. Coopting stakeholders and consumers into decisions regarding micronutrient recommendations is an important step...... towards achieving a greater link between micronutrient recommendations and behaviour. This study aims to examine the rationale and processes associated with consumer and stakeholder involvement in setting micronutrient recommendations across Europe. Subjects/Methods: Using the contacts established through...... the Eurreca network of excellence (commissioned by the European Commission), the research involved in-depth desk research of key documents and communication channels linked to the process of setting micronutrient recommendations across seven countries: the United Kingdom, Norway, Denmark, Germany, Spain...

  17. Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity.

    Science.gov (United States)

    Xie, Fang; Ke, Alice B; Bowers, Gary D; Zamek-Gliszczynski, Maciej J

    2015-08-01

    Blood cells are considered an important distributional compartment for metformin based on the high blood-to-plasma partition ratio (B/P) in humans (>10 at Cmin). However, literature reports of metformin's intrinsic in vitro B/P values are lacking. At present, the extent and rate of metformin cellular partitioning was determined in incubations of fresh human and rat blood with [(14)C]metformin for up to 1 week at concentrations spanning steady-state plasma Cmin, Cmax, and a concentration associated with lactic acidosis. The results showed that metformin's intrinsic equilibrium B/P was ∼0.8-1.4 in blood, which is <10% of the reported clinical value. Kinetics of metformin partitioning into human blood cells and repartitioning back into plasma were slow (repartitioning half-life ∼32-39 hours). These data, along with in vivo rapid and efficient renal clearance of plasma metformin (plasma renal extraction ratio ∼90%-100%), explain why the clinical terminal half-life of metformin in plasma (6 hours) is 3- to 4-fold shorter than the half-life in whole blood (18 hours) and erythrocytes (23 hours). The rate constant for metformin repartitioning from blood cells to plasma (∼0.02 h(-1)) is far slower than the clinical renal elimination rate constant (0.3 h(-1)). Blood distributional rate constants were incorporated into a metformin physiologically-based pharmacokinetic model, which predicted the differential elimination half-life in plasma and blood. The present study demonstrates that the extent of cellular drug partitioning in blood observed in a dynamic in vivo system may be very different from the static in vitro values when repartitioning from blood cells is far slower than clearance of drug in plasma.

  18. Qualitative Value Profiling

    DEFF Research Database (Denmark)

    Duus, Henrik Johannsen; Bjerre, Mogens

    2015-01-01

    Qualitative value profiling (QVP) is a relatively unknown method of strategic analysis for companies in international business-to-business settings. The purpose of QVP is to reduce the information complexity that is faced by international companies in dealing with business partners. The QVP method...... and consequently, for the advancement of international development. Further use of QVP is recommended and suggestions for future research are provided....

  19. 76 FR 81 - Adoption of Recommendation

    Science.gov (United States)

    2011-01-03

    ...; ] ADMINISTRATIVE CONFERENCE OF THE UNITED STATES Adoption of Recommendation AGENCY: Administrative Conference of... the attached recommendation at its Fifty-third Plenary Session. The recommendation addresses issues... makes recommendations for improvements to the agencies, collectively or individually, and to...

  20. Values Research

    Science.gov (United States)

    2009-10-01

    horizontal vs. vertical. • According to the theory of Planned Behavior ( Ajzen , 1988, 2002) attitude, subjective norms and perceived control...determines intention which may end in behavior . 7 Defining Human Values Cross-cultural theories on values emerged in the 80s developed by three main...attitudes with social structure. 4 Defining Human Values • According to Parsons (Parsons & Shils, 1951), values instigate behavior . • In line

  1. Management recommendations: Lee Metcalf Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a review of land management practices at the Lee Metcalf National Wildlife Refuge, by a land use specialist. Recommendations, time frame and...

  2. Disability: recommendations for eye programmes

    Directory of Open Access Journals (Sweden)

    2013-05-01

    Full Text Available In 2012, CBM’s Medical Eye Care Advisory Working Group met in Hyderabad, India to discuss the inclusion of people with disabilities in eye care.As a result of these discussions, recommendations were made.

  3. Management recommendations: Sand Lake Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a review of land management practices at the Sand Lake National Wildlife Refuge, by a land use specialist. Recommendations, time frame and...

  4. Strategic Arrivals Recommendation Tool Project

    Data.gov (United States)

    National Aeronautics and Space Administration — During the conduct of a NASA Research Announcement (NRA) in 2012 and 2013, the Mosaic ATM team first developed the Strategic Arrivals Recommendation Tool concept, or...

  5. Management recommendations: Benton Lake Complex

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a review of land management practices at the Benton Lake Complex, by a land use specialist. Recommendations, time frame and additional comments are...

  6. Dietary Recommendations for Healthy Children

    Science.gov (United States)

    ... Restaurant Deciphering the Menu Ordering Your Meal Eating Fast Food Dining Out Tips by Cuisine Physical Activity Fitness ... Food and Beverage Toolkit Dietary Recommendations for Healthy Children Updated:Jul 22,2016 The American Heart Association ...

  7. RECOMMENDER SYSTEMS IN SOCIAL NETWORKS

    Directory of Open Access Journals (Sweden)

    Cleomar Valois Batista Jr

    2011-12-01

    Full Text Available The continued and diversified growth of social networks has changed the way in which users interact with them. With these changes, what once was limited to social contact is now used for exchanging ideas and opinions, creating the need for new features. Users have so much information at their fingertips that they are unable to process it by themselves; hence, the need to develop new tools. Recommender systems were developed to address this need and many techniques were used for different approaches to the problem. To make relevant recommendations, these systems use large sets of data, not taking the social network of the user into consideration. Developing a recommender system that takes into account the social network of the user is another way of tackling the problem. The purpose of this project is to use the theory of six degrees of separation (Watts 2003 amongst users of a social network to enhance existing recommender systems.

  8. Recommended Practices for Spreadsheet Testing

    CERN Document Server

    Panko, Raymond R

    2006-01-01

    This paper presents the authors recommended practices for spreadsheet testing. Documented spreadsheet error rates are unacceptable in corporations today. Although improvements are needed throughout the systems development life cycle, credible improvement programs must include comprehensive testing. Several forms of testing are possible, but logic inspection is recommended for module testing. Logic inspection appears to be feasible for spreadsheet developers to do, and logic inspection appears to be safe and effective.

  9. Tourism recommendation system: empirical investigation

    OpenAIRE

    Petrevska, Biljana; Saso KOCESKI

    2012-01-01

    The paper makes an attempt to justify the necessity of implementing recommendation system which will assist tourists in identification of their ideal holiday. The proposed recommendation system based on collaborative filtering notes positive impulses in the case of Macedonia. A software module is developed being capable to generate a personalized list of favorable and tailor-made items. The research outcomes indicate that the designed national tourism web portal can provide satisfactory perfo...

  10. User Profiling for Recommendation System

    OpenAIRE

    Kanoje, Sumitkumar; Girase, Sheetal; Mukhopadhyay, Debajyoti

    2015-01-01

    Recommendation system is a type of information filtering systems that recommend various objects from a vast variety and quantity of items which are of the user interest. This results in guiding an individual in personalized way to interesting or useful objects in a large space of possible options. Such systems also help many businesses to achieve more profits to sustain in their filed against their rivals. But looking at the amount of information which a business holds it becomes difficult to...

  11. Introduction on health recommender systems.

    Science.gov (United States)

    Sanchez-Bocanegra, C L; Sanchez-Laguna, F; Sevillano, J L

    2015-01-01

    People are looking for appropriate health information which they are concerned about. The Internet is a great resource of this kind of information, but we have to be careful if we don't want to get harmful info. Health recommender systems are becoming a new wave for apt health information as systems suggest the best data according to the patients' needs.The main goals of health recommender systems are to retrieve trusted health information from the Internet, to analyse which is suitable for the user profile and select the best that can be recommended, to adapt their selection methods according to the knowledge domain and to learn from the best recommendations.A brief definition of recommender systems will be given and an explanation of how are they incorporated in the health sector. A description of the main elementary recommender methods as well as their most important problems will also be made. And, to finish, the state of the art will be described.

  12. Recommendations

    DEFF Research Database (Denmark)

    Baumeister, Ruth

    2016-01-01

    This article discusses three book publications: C. Kerez: Uncertain Certainty, Tokyo, 2013 H. Hertzberger: Lessons for students in architecture, Rotterdam, 2006, (1991) A. Jorn: Om Formen, Silkeborg, 2014, (1958)...

  13. Dynamic Recommendation: Disease Prediction and Prevention Using Recommender System

    Directory of Open Access Journals (Sweden)

    Mahdi Nasiri

    2016-06-01

    Full Text Available Background: In today’s world, chronic diseases are predominant health problems and cause heavy burden on society; therefore early diagnosis and even prediction of the disease is a way to reduce this burden. In this project, we tried to use recommender system to predict which other diseases a chronic patient is susceptible for. Methods: In this study, through a dynamic recommender system, we evaluated patients’ treatment destiny during the time. Results: It was shown that our method increased accuracy and reduced error compared with other recommendation methods in disease prediction. Conclusion: Compared to current usual methods, in our method we used previous patients’ characteristics as one of the factorization variables to predict destiny of future patients. Furthermore, using this method, we can predict which complication or disease the patient would suffer from first in future. Therefore, we can manage policies toward disease burden reduction by implementing prevention programs.

  14. Classification of Recommender Expertise in the Wikipedia Recommender System

    DEFF Research Database (Denmark)

    Jensen, Christian D.; Pilkauskas, Povilas; Lefévre, Thomas

    2011-01-01

    to the quality of articles. The Wikipedia Recommender System (WRS) was developed to help users determine the credibility of articles based on feedback from other Wikipedia users. The WRS implements a collaborative filtering system with trust metrics, i.e., it provides a rating of articles which emphasizes...... ratings reflected the average competence of recommenders across all subject areas. We have now developed a new version of the WRS, which evaluates the expertise of recommenders within different subject areas. In order to do this, we need to identify a way to classify the subject area of all the articles......The Wikipedia is a web-based encyclopedia, written and edited collaboratively by Internet users. The Wikipedia has an extremely open editorial policy that allows anybody, to create or modify articles. This has promoted a broad and detailed coverage of subjects, but also introduced problems relating...

  15. Improving Tensor Based Recommenders with Clustering

    DEFF Research Database (Denmark)

    Leginus, Martin; Dolog, Peter; Zemaitis, Valdas

    2012-01-01

    Social tagging systems (STS) model three types of entities (i.e. tag-user-item) and relationships between them are encoded into a 3-order tensor. Latent relationships and patterns can be discovered by applying tensor factorization techniques like Higher Order Singular Value Decomposition (HOSVD),...... of the recommendations and execution time are improved and memory requirements are decreased. The clustering is motivated by the fact that many tags in a tag space are semantically similar thus the tags can be grouped. Finally, promising experimental results are presented...

  16. Matching the decay half-life with the biological half-life: ImmunoPET imaging with (44)Sc-labeled cetuximab Fab fragment.

    Science.gov (United States)

    Chakravarty, Rubel; Goel, Shreya; Valdovinos, Hector F; Hernandez, Reinier; Hong, Hao; Nickles, Robert J; Cai, Weibo

    2014-12-17

    Scandium-44 (t1/2 = 3.9 h) is a relatively new radioisotope of potential interest for use in clinical positron emission tomography (PET). Herein, we report, for the first time, the room-temperature radiolabeling of proteins with (44)Sc for in vivo PET imaging. For this purpose, the Fab fragment of Cetuximab, a monoclonal antibody that binds with high affinity to epidermal growth factor receptor (EGFR), was generated and conjugated with N-[(R)-2-amino-3-(para-isothiocyanato-phenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-N,N,N',N″,N″-pentaacetic acid (CHX-A″-DTPA). The high purity of Cetuximab-Fab was confirmed by SDS-PAGE and mass spectrometry. The potential of the bioconjugate for PET imaging of EGFR expression in human glioblastoma (U87MG) tumor-bearing mice was investigated after (44)Sc labeling. PET imaging revealed rapid tumor uptake (maximum uptake of ∼12% ID/g at 4 h postinjection) of (44)Sc-CHX-A″-DTPA-Cetuximab-Fab with excellent tumor-to-background ratio, which might allow for same day PET imaging in future clinical studies. Immunofluorescence staining was conducted to correlate tracer uptake in the tumor and normal tissues with EGFR expression. This successful strategy for immunoPET imaging of EGFR expression using (44)Sc-CHX-A″-DTPA-Cetuximab-Fab can make clinically translatable advances to select the right population of patients for EGFR-targeted therapy and also to monitor the therapeutic efficacy of anti-EGFR treatments.

  17. Recommender Systems using Graph Theory

    Directory of Open Access Journals (Sweden)

    Vishal Venkatraman

    2013-08-01

    Full Text Available Recommender systems have become one of the important tools in E-Commerce. They combine the ratings of services or products by one user with the ratings from other users to answer similar interest queries with predictions and suggestions. The users thus receive anonymous recommendations from people similar interests. Even though this process seems unobjectionable, it aggregates user preferences, which can be tapped to recognise information about a particular user. Users who rate products or services across different types or domains in the systems are the major victims for this exploitation. We could determine the advantages and risks by performing a detailed analysis with a particular recommendation algorithm, but it would be difficult to draw general conclusions from this approach. In this paper, we aim for an algorithm independent analysis by applying a graph-theoretic model. By employing this model, we show that a user benefits most from recommendations based on similarity between the various products rated by the users. This paper tries to draw a graph through the various items rated by the users and finds the items that are most common among the user and his friends which is then recommended to him.

  18. Challenging the Long Tail Recommendation

    CERN Document Server

    Yin, Hongzhi; Li, Jing; Yao, Junjie; Chen, Chen

    2012-01-01

    The success of "infinite-inventory" retailers such as Amazon.com and Netflix has been largely attributed to a "long tail" phenomenon. Although the majority of their inventory is not in high demand, these niche products, unavailable at limited-inventory competitors, generate a significant fraction of total revenue in aggregate. In addition, tail product availability can boost head sales by offering consumers the convenience of "one-stop shopping" for both their mainstream and niche tastes. However, most of existing recommender systems, especially collaborative filter based methods, can not recommend tail products due to the data sparsity issue. It has been widely acknowledged that to recommend popular products is easier yet more trivial while to recommend long tail products adds more novelty yet it is also a more challenging task. In this paper, we propose a novel suite of graph-based algorithms for the long tail recommendation. We first represent user-item information with undirected edge-weighted graph and i...

  19. [Recommendations for antibiotic monitoring in ICU patients].

    Science.gov (United States)

    Alvarez, Francisco; Olaechea, Pedro; Grau, Santiago; Marín, Mónica; Domínguez, Alfonso; Martínez-Lanao, José; Soy, Dolors; Alos, Manuel; Victoria, María; Sádaba, Belén; Mediavilla, Africa; Fatela, Daniel

    2008-01-01

    Monitoring plasma concentrations of antimicrobial agents used to treat infection in critically ill patients is one of the recommended strategies for improving clinical outcome. Drug monitoring has a double aim: to limit adverse events and to increase the effectiveness of the drugs. In clinical practice, however, this approach is mainly limited to monitoring plasma concentrations of vancomycin and aminoglycosides, although future extension to other antimicrobial agents would be desirable. Application of this technique varies considerably between hospitals, and this makes interpretation and comparison of the results obtained difficult. For this reason, representatives of various scientific societies related to the pharmacokinetic area have developed a series of recommendations for monitoring plasma concentrations of antimicrobials using vancomycin and several aminoglycosides as the reference. The recommendations are based on 14 questions encompassing all steps of the process: indication for the test, blood sampling (timing of blood collection, blood volume, tubes), transport to the laboratory, techniques applied, normal values, dose adjustment, and reporting the results. The purpose of these guidelines is to develop a process of monitoring plasma antimicrobial concentrations that is as homogeneous as possible to facilitate the design of multicenter studies, as well as the interpretation and comparison of results.

  20. Customization Using Fuzzy Recommender Systems

    Institute of Scientific and Technical Information of China (English)

    Ronald R. Yager

    2004-01-01

    We discuss some methods for constructing recommender systems. An important feature of the methods studied here is that we assume the availability of a description, representation, of the objects being considered for recommendation. The approaches studied here differ from collaborative filtering in that we only use pReferences information from the individual for whom we are providing the recommendation and make no use the preferences of other collaborators. We provide a detailed discussion of the construction of the representation schema used. We consider two sources of information about the users preferences. The first are direct statements about the type of objects the user likes. The second source of information comes from ratings of objects which the user has experienced.

  1. When are recommender systems useful?

    CERN Document Server

    Blattner, Marcel; Laureti, Paolo

    2007-01-01

    Recommender systems are crucial tools to overcome the information overload brought about by the Internet. Rigorous tests are needed to establish to what extent sophisticated methods can improve the quality of the predictions. Here we analyse a refined correlation-based collaborative filtering algorithm and compare it with a novel spectral method for recommending. We test them on two databases that bear different statistical properties (MovieLens and Jester) without filtering out the less active users and ordering the opinions in time, whenever possible. We find that, when the distribution of user-user correlations is narrow, simple averages work nearly as well as advanced methods. Recommender systems can, on the other hand, exploit a great deal of additional information in systems where external influence is negligible and peoples' tastes emerge entirely. These findings are validated by simulations with artificially generated data.

  2. Recommended Practices in Thrust Measurements

    Science.gov (United States)

    Polk, James E.; Pancotti, Anthony; Haag, Thomas; King, Scott; Walker, Mitchell; Blakely, Joseph; Ziemer, John

    2013-01-01

    Accurate, direct measurement of thrust or impulse is one of the most critical elements of electric thruster characterization, and one of the most difficult measurements to make. The American Institute of Aeronautics and Astronautics has started an initiative to develop standards for many important measurement processes in electric propulsion, including thrust measurements. This paper summarizes recommended practices for the design, calibration, and operation of pendulum thrust stands, which are widely recognized as the best approach for measuring micro N- to mN-level thrust and micro Ns-level impulse bits. The fundamentals of pendulum thrust stand operation are reviewed, along with its implementation in hanging pendulum, inverted pendulum, and torsional balance configurations. Methods of calibration and recommendations for calibration processes are presented. Sources of error are identified and methods for data processing and uncertainty analysis are discussed. This review is intended to be the first step toward a recommended practices document to help the community produce high quality thrust measurements.

  3. The value of value congruence.

    Science.gov (United States)

    Edwards, Jeffrey R; Cable, Daniel M

    2009-05-01

    Research on value congruence has attempted to explain why value congruence leads to positive outcomes, but few of these explanations have been tested empirically. In this article, the authors develop and test a theoretical model that integrates 4 key explanations of value congruence effects, which are framed in terms of communication, predictability, interpersonal attraction, and trust. These constructs are used to explain the process by which value congruence relates to job satisfaction, organizational identification, and intent to stay in the organization, after taking psychological need fulfillment into account. Data from a heterogeneous sample of employees from 4 organizations indicate that the relationships that link individual and organizational values to outcomes are explained primarily by the trust that employees place in the organization and its members, followed by communication, and, to a lesser extent, interpersonal attraction. Polynomial regression analyses reveal that the relationships emanating from individual and organizational values often deviated from the idealized value congruence relationship that underlies previous theory and research. The authors' results also show that individual and organizational values exhibited small but significant relationships with job satisfaction and organizational identification that bypassed the mediators in their model, indicating that additional explanations of value congruence effects should be pursued in future research. (c) 2009 APA, all rights reserved.

  4. TOURISM RECOMMENDATION SYSTEM: EMPIRICAL INVESTIGATION

    Directory of Open Access Journals (Sweden)

    Biljana PETREVSKA

    2012-12-01

    Full Text Available The paper makes an attempt to justify the necessity of implementing recommendation system which will assist tourists in identification of their ideal holiday. The proposed recommendation system based on collaborative filtering notes positive impulses in the case of Macedonia. A software module is developed being capable to generate a personalized list of favorable and tailor-made items. The research outcomes indicate that the designed national tourism web portal can provide satisfactory performance and may be of high importance to all key-tourism actors in the process of identifying measures necessary for creating competitive tourism product.

  5. Value Representations

    DEFF Research Database (Denmark)

    Rasmussen, Majken Kirkegaard; Petersen, Marianne Graves

    2011-01-01

    Stereotypic presumptions about gender affect the design process, both in relation to how users are understood and how products are designed. As a way to decrease the influence of stereotypic presumptions in design process, we propose not to disregard the aspect of gender in the design process......, as the perspective brings valuable insights on different approaches to technology, but instead to view gender through a value lens. Contributing to this perspective, we have developed Value Representations as a design-oriented instrument for staging a reflective dialogue with users. Value Representations...

  6. Recommender System for Personalised Wellness Therapy

    Directory of Open Access Journals (Sweden)

    Thean Pheng Lim

    2013-10-01

    Full Text Available rising costs and risks in health care have shifted the preference of individuals from health treatment to disease prevention. This prevention treatment is known as wellness. In recent years, the Internet has become a popular place for wellness-conscious users to search for wellness-related information and solutions. As the user community becomes more wellness conscious, service improvement is needed to help users find relevant personalised wellness solutions. Due to rapid development in the wellness market, users value convenient access to wellness services. Most wellness websites reflect common health informatics approaches; these amount to more than 70,000 sites worldwide. Thus, the wellness industry should improve its Internet services in order to provide better and more convenient customer service. This paper discusses the development of a wellness recommender system that would help users find and adapt suitable personalised wellness therapy treatments based on their individual needs. This paper introduces new approaches that enhance the convenience and quality of wellness information delivery on the Internet. The wellness recommendation task is performed using an Artificial Intelligence technique of hybrid case-based reasoning (HCBR. HCBR solves users’ current wellness problems by applying solutions from similar cases in the past. From the evaluation results for our prototype wellness recommendation system, we conclude that wellness consultants are using consistent wellness knowledge to recommend solutions for sample wellness cases generated through an online consultation form. Thus, the proposed model can be integrated into wellness websites to enable users to search for suitable personalized wellness therapy treatment based on their health condition.

  7. Understanding Recommender Dynamics driving Box Office Revenues

    CERN Document Server

    Yeung, C H; Jin, C -H

    2010-01-01

    We introduce a simple model to investigate the underlying dynamics driving movie box office. Without an explicit reliance on time, the box office of movies evolves naturally by movie-movie competition through reviews listed on a centralized recommender system. A simple mean-field approximation is employed which assumes an average interaction between the competing movies, and describes the interesting box office dynamics. Box office hits are found for movies with quality beyond a critical value, leading to booms in gross box office. Such critical value is dependent on the reviewing behaviors, intention of movie goers for new movies, and the quality of the peer competing movies. Finally we compare our analytical results with simulations and real system and obtain qualitative agreements, suggesting the present model in describing the fundamental dynamics of box office.

  8. User Modeling for Personalized Recommender Systems

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    This paper models a user's interest and value related characteristics based on the extension by using neural networks and econometric techniques to the concept of user model in recommender systems. A two-dimensional taxonomy of user model was proposed in terms of the content and persistence of user characteristics. A user interest model and a customer lifetime value model were developed for the proposed taxonomy framework, to capture the time-dependent evolving nature of user's interests and his/her long-term profitability. The proposed models were empirically validated by using real customer data from a bee product company in health care industry. The experimental results show that these models provide effective assistant tools for the company to target its most valuable customers and implement one-to-one personalized services.

  9. Valor nutricional da merenda e sua contribuição para as recomendações nutricionais do pré-escolar, matriculado em CEAPE The nutritional value of the school lunch and its contribution to the fulfilling of the nutritional recommendations of preschoolers enrolled in the Center for Education and Feeding of the Preschooler

    Directory of Open Access Journals (Sweden)

    Rosa Nilda Mazzilli

    1987-06-01

    Full Text Available Estudou-se o valor nutricional da merenda escolar e os vários tipos de preparações oferecidas aos pré-escolares, matriculados nos Centros de Educação e Alimentação do Pré-Escolar (CEAPEs. Analisou-se sua contribuição para satisfazer as recomendações diárias de energia e de nutrientes desse grupo etário da população. O estudo abrangeu 346 pré-escolares de CEAPEs implantados em 6 cidades do interior do Estado de São Paulo. As preparações servidas com maior freqüência em todos os CEAPEs foram: leite enriquecido, proteína testurizada de soja, sopas e mingaus de produtos à base dessa leguminosa. O valor energético médio variou de 210 a 403 calorias, e o de proteínas, de 5,7 a 12,0 g. Em relação a vitaminas e minerais, a merenda mostrou-se deficiente na maioria desses nutrientes e em todas as cidades estudadas. A contribuição da merenda para as recomendações diárias de energia e de proteína ficou entre 21 e 44% e de 13 a 26%, respectivamente. Quanto ao teor vitamínico, a merenda atendeu ao previsto pelo PNAE em relação às vitaminas A, B1 e B2, apenas em três cidades; quanto aos minerais, somente o cálcio, em uma localidade, atingiu o estabelecido pelo Programa. A merenda ainda que não seja expressiva sua contribuição para as recomendações nutricionais diárias, constitui suplemento na dieta habitual do pré-escolar.The present paper studied the nutritional value of the school lunch and the variety of the preparations offered to preschool children drawn from Preschool Education and Feeding Centres (CEAPE. Its contribution to the energy and nutrients intake of this population group was analysed. Three hundred and forty six preschool children belonging to six towns of the State of S. Paulo were studied. The preparations most often served in all the CEAPEs studied were enriched milk, soy texturized protein, soups and mushes including soy bean. The average energy value of the school lunch varied between 210

  10. Recommending Peers for Learning: Matching on Dissimilarity in Interpretations to Provoke Breakdown

    Science.gov (United States)

    Rajagopal, Kamakshi; van Bruggen, Jan M.; Sloep, Peter B.

    2017-01-01

    People recommenders are a widespread feature of social networking sites and educational social learning platforms alike. However, when these systems are used to extend learners' Personal Learning Networks, they often fall short of providing recommendations of learning value to their users. This paper proposes a design of a people recommender based…

  11. Office lighting: A review of 80 years of standards and recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Osterhaus, W.K.E.

    1993-05-01

    This paper traces the development of quantitative office lighting standards from its beginnings to the present. It discusses the sources of recommended lighting practice, the nature of the quantitative recommendations, and trends in recommended values on a comparative basis. A critical assessment of contemporary standards is provided within this historical context.

  12. Recommending Peers for Learning: Matching on Dissimilarity in Interpretations to Provoke Breakdown

    Science.gov (United States)

    Rajagopal, Kamakshi; van Bruggen, Jan M.; Sloep, Peter B.

    2017-01-01

    People recommenders are a widespread feature of social networking sites and educational social learning platforms alike. However, when these systems are used to extend learners' Personal Learning Networks, they often fall short of providing recommendations of learning value to their users. This paper proposes a design of a people recommender based…

  13. The ageing practitioner: ANZCA's recommendations.

    Science.gov (United States)

    Baker, A B

    2016-04-01

    The aim is to present recommendations of the Australian and New Zealand College of Anaesthetists (ANZCA) with respect to practice implications for ageing specialists, together with brief discussion of effects of ageing on professional medical capabilities and recommendations on preparing to retire from medical practice. Practitioners should recognise that planning for retirement is part of good management of a medical career, and that the ageing process will inevitably compromise their ability to treat patients safely unless they retire at the appropriate time. Planning should include adequate financial preparation, and cultivation of interests and friends outside medicine. Practitioners should also realise that insight is likely to be compromised, so that they should seek colleagues who are trusted to advise them if/when they begin to lose competency. Lastly all practitioners should ensure that they consult a General Practitioner frequently, and that they have arranged all the proper legal instructions such as a Will, a Power of Attorney and an Advanced Health Directive.The ANZCA recommendations concerning ageing specialists have wide application to all medical specialties, not just for anaesthetists, and therefore all Medical Colleges should generate their own specific recommendations for ageing practitioners and the general effects of fatigue particularly for aged practitioners. © The Royal Australian and New Zealand College of Psychiatrists 2015.

  14. Ubiquitous Multicriteria Clinic Recommendation System.

    Science.gov (United States)

    Chen, Toly

    2016-05-01

    Advancements in information, communication, and sensor technologies have led to new opportunities in medical care and education. Patients in general prefer visiting the nearest clinic, attempt to avoid waiting for treatment, and have unequal preferences for different clinics and doctors. Therefore, to enable patients to compare multiple clinics, this study proposes a ubiquitous multicriteria clinic recommendation system. In this system, patients can send requests through their cell phones to the system server to obtain a clinic recommendation. Once the patient sends this information to the system, the system server first estimates the patient's speed according to the detection results of a global positioning system. It then applies a fuzzy integer nonlinear programming-ordered weighted average approach to assess four criteria and finally recommends a clinic with maximal utility to the patient. The proposed methodology was tested in a field experiment, and the experimental results showed that it is advantageous over two existing methods in elevating the utilities of recommendations. In addition, such an advantage was shown to be statistically significant.

  15. A Flexible Electronic Commerce Recommendation System

    Science.gov (United States)

    Gong, Songjie

    Recommendation systems have become very popular in E-commerce websites. Many of the largest commerce websites are already using recommender technologies to help their customers find products to purchase. An electronic commerce recommendation system learns from a customer and recommends products that the customer will find most valuable from among the available products. But most recommendation methods are hard-wired into the system and they support only fixed recommendations. This paper presented a framework of flexible electronic commerce recommendation system. The framework is composed by user model interface, recommendation engine, recommendation strategy model, recommendation technology group, user interest model and database interface. In the recommender strategy model, the method can be collaborative filtering, content-based filtering, mining associate rules method, knowledge-based filtering method or the mixed method. The system mapped the implementation and demand through strategy model, and the whole system would be design as standard parts to adapt to the change of the recommendation strategy.

  16. The Value of Value Sets

    DEFF Research Database (Denmark)

    Sløk-Madsen, Stefan Kirkegaard; Christensen, Jesper

    The world over classrooms in business schools are being taught that corporate values can impact performance. The argument is typically that culture matter more than strategy plans and culture can be influenced and indeed changed by a shared corporate value set. While the claim seems intuitively a...... a unique contribution to the effects of investment in shared company values, and to whether agent rationality can be fundamentally changed by committed organizational efforts.......The world over classrooms in business schools are being taught that corporate values can impact performance. The argument is typically that culture matter more than strategy plans and culture can be influenced and indeed changed by a shared corporate value set. While the claim seems intuitively...... and anecdotally true surprisingly little hard evidence has been produced either for or against. This study attempts to rectify this. The study claims that for corporate values to matter they must at least align, and potentially alter, employee decision-making hence their concept of optimality and rational...

  17. Economic value of walkability

    Energy Technology Data Exchange (ETDEWEB)

    Litman, T.

    2004-10-12

    Traditional transportation planning and evaluation practices treat walking as a minor transport mode. However, it is evident that walking is a critical component of the transport system. This paper presents a series of methods to evaluate the value of walking and walkability, which is defined as the quality of walking conditions, including safety, comfort and convenience. The socio-economic benefits of walking and walkability were discussed, including basic mobility, consumer cost savings and reduced external costs. Efficient land use, community livability, improved public health, economic development and support for equity objectives were also presented as potential benefits. It was concluded that walking receives less than its appropriate share of transportation resources, and that improvements in walkability can provide a high economic return on investment. Increased government funding to walking facilities and programs was recommended. Other recommendations included: shifting road space from traffic and parking lanes to sidewalks and paths; and policies to create more walkable safety and comfort. These recommendations comply with other transport and land use management reforms to reduce automobile dependency and create greater accessibility. refs., tabs., figs.

  18. IVOA Recommendation: IVOA Support Interfaces

    CERN Document Server

    Graham, Matthew; Grid,

    2011-01-01

    This document describes the minimum interface that a (SOAP- or REST-based) web service requires to participate in the IVOA. Note that this is not required of standard VO services developed prior to this specification, although uptake is strongly encouraged on any subsequent revision. All new standard VO services, however, must feature a VOSI-compliant interface. This document has been produced by the Grid and Web Services Working Group. It has been reviewed by IVOA Members and other interested parties, and has been endorsed by the IVOA Executive Committee as an IVOA Recommendation. It is a stable document and may be used as reference material or cited as a normative reference from another document. IVOA's role in making the Recommendation is to draw attention to the specification and to promote its widespread deployment. This enhances the functionality and interoperability inside the Astronomical Community.

  19. Scientific and educational recommender systems

    Science.gov (United States)

    Guseva, A. I.; Kireev, V. S.; Bochkarev, P. V.; Kuznetsov, I. A.; Philippov, S. A.

    2017-01-01

    This article discusses the questions associated with the use of reference systems in the preparation of graduates in physical function. The objective of this research is creation of model of recommender system user from the sphere of science and education. The detailed review of current scientific and social network for scientists and the problem of constructing recommender systems in this area. The result of this study is to research user information model systems. The model is presented in two versions: the full one - in the form of a semantic network, and short - in a relational form. The relational model is the projection in the form of semantic network, taking into account the restrictions on the amount of bonds that characterize the number of information items (research results), which interact with the system user.

  20. EURRECA: development of tools to improve the alignment of micronutrient recommendations

    NARCIS (Netherlands)

    Matthys, C.; Bucchini, L.; Busstra, M.C.; Cavelaars, A.J.E.M.; Eleftheriou, P.; Garcia-Alvarez, A.; Fairweather-Tait, S.; Gurinovic, M.; Ommen, van B.; Contor, L.

    2010-01-01

    Approaches through which reference values for micronutrients are derived, as well as the reference values themselves, vary considerably across countries. Harmonisation is needed to improve nutrition policy and public health strategies. The EURRECA (EURopean micronutrient RECommendations Aligned, htt

  1. Recommendation system for trip planning

    OpenAIRE

    Hlupič, Marko

    2011-01-01

    The thesis describes a web application used for recommending tourist destinations and trip planning. Given that one location offers several tourist attractions and activities, the destination is divided into a location, containing only the name and the corresponding region, and the possible activity that could take place in that location. The users choose some activities and later on decide whether these locations met their expectations or not. The application is divided into two parts: the f...

  2. Finding and Recommending Scholarly Articles

    Science.gov (United States)

    Kurtz, Michael J.; Henneken, Edwin A.

    2014-05-01

    The rate at which scholarly literature is being produced has been increasing at approximately 3.5 percent per year for decades. This means that during a typical 40 year career the amount of new literature produced each year increases by a factor of four. The methods scholars use to discover relevant literature must change. Just like everybody else involved in information discovery, scholars are confronted with information overload. Two decades ago, this discovery process essentially consisted of paging through abstract books, talking to colleagues and librarians, and browsing journals. A time-consuming process, which could even be longer if material had to be shipped from elsewhere. Now much of this discovery process is mediated by online scholarly information systems. All these systems are relatively new, and all are still changing. They all share a common goal: to provide their users with access to the literature relevant to their specific needs. To achieve this each system responds to actions by the user by displaying articles which the system judges relevant to the user's current needs. Recently search systems which use particularly sophisticated methodologies to recommend a few specific papers to the user have been called "recommender systems". These methods are in line with the current use of the term "recommender system" in computer science. We do not adopt this definition, rather we view systems like these as components in a larger whole, which is presented by the scholarly information systems themselves. In what follows we view the recommender system as an aspect of the entire information system; one which combines the massive memory capacities of the machine with the cognitive abilities of the human user to achieve a human-machine synergy.

  3. High flow air sampling for determination of alpha long half-life emitters: area monitoring of a radioactive material disposal; Amostragem de ar de alto fluxo para determinacao de alfa emissores de meia vida longa: monitoracao de area em um deposito de material radioativo

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, W.S. [Industrias Nucleares do Brasil (SR/FCN/INB), Itatiaia, RJ (Brazil). Servico de Radioprotecao. Fabrica do Combustivel Nuclear; Kelecom, A. [Universidade Federal Fluminense (LARARA-PLS/GETA/UFF), Niteroi, RJ (Brazil). Lab. de Radiobiologia e Radiometria Pedro Lopes dos Santos. Grupo de Estudos em Temas Ambientais

    2015-07-01

    The Ore Treatment Unit (UTM) is a mine and closed uranium plant, located in Caldas, Minas Gerais, Brazil. It has a radioactive material disposal composed primarily of pie II and mesothorium. It is stored in six sheds designated C-01, C-02, C-05, C-06, C-07 and C-09. This study aims to present the high flow area monitoring program and results obtained in 2009. The threshold derived from concentration in the air was 0.25 Bq m{sup -3}. The average of the activity concentrations in 2009 were: for C-01 1.17 Bq m{sup -3}; C-02 0.006 Bq m{sup -3}; C-05 1.98 Bq m{sup -3}; C-06 2.14 Bq m{sup -3}; C-07 0.34 Bq m{sup -3} and C-09 0,025 Bq m{sup -3}. Such values indicate that the control stay is an important factor in occupational workers' control, as well as the use of EPI's and behavioral care, besides radioprotection training to allow the access to the areas. No worker, supervisor or visitor reached the limit research.

  4. APLAR rheumatoid arthritis treatment recommendations.

    Science.gov (United States)

    Lau, Chak Sing; Chia, Faith; Harrison, Andrew; Hsieh, Tsu-Yi; Jain, Rahul; Jung, Seung Min; Kishimoto, Mitsumasa; Kumar, Ashok; Leong, Khai Pang; Li, Zhanguo; Lichauco, Juan Javier; Louthrenoo, Worawit; Luo, Shue-Fen; Nash, Peter; Ng, Chin Teck; Park, Sung-Hwan; Suryana, Bagus Putu Putra; Suwannalai, Parawee; Wijaya, Linda Kurniaty; Yamamoto, Kazuhiko; Yang, Yue; Yeap, Swan Sim

    2015-09-01

    Rheumatoid arthritis is a chronic inflammatory condition that affects approximately 1% of the world's population. There are a wide number of guidelines and recommendations available to support the treatment of rheumatoid arthritis; however, the evidence used for these guidelines is predominantly based on studies in Caucasian subjects and may not be relevant for rheumatoid arthritis patients in the Asia-Pacific region. Therefore, the Asia Pacific League of Associations for Rheumatology established a Steering Committee in 2013 to address this issue. The AGREE II instrument and the ADAPTE Collaboration framework were applied to systematically identify, appraise, synthesize, and adapt international rheumatoid arthritis guidelines for use in the Asia-Pacific region. Forty rheumatoid arthritis treatment recommendations, based on evidence and expert opinion, were drafted and are presented in this report. The Asia Pacific of Associations for Rheumatology rheumatoid arthritis treatment recommendations are intended to serve as a reference for best practice management of rheumatoid arthritis in Asia-Pacific, focusing on local issues to ensure the delivery of basic care for these patients, and to improve their outcomes. In addition, the document will serve as a reference for national rheumatology associations in Asia-Pacific for developing guidelines in their respective countries. © 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  5. Value system for distruptive innovation

    DEFF Research Database (Denmark)

    Li, Jizhen; Zhang, Si; Hu, Yimei

    After reviewing the theory of disruptive innovation, this paper forms a new framework for analyzing disruptive innovation from the perspective of value system, which suggests that the technology per se is the value source, industrial Ecosystem is the carrier, business model is the instrument...... hopefully find its root. According to the framework, it summarizes different types of disruption that LED brings to traditional lighting industry in Guangdong Province, and proposes policy recommendations to accelerate the development of LED lighting industry in Guangdong Province....

  6. Towards Information Enrichment through Recommendation Sharing

    Science.gov (United States)

    Weng, Li-Tung; Xu, Yue; Li, Yuefeng; Nayak, Richi

    Nowadays most existing recommender systems operate in a single organisational basis, i.e. a recommender system recommends items to customers of one organisation based on the organisation's datasets only. Very often the datasets of a single organisation do not have sufficient resources to be used to generate quality recommendations. Therefore, it would be beneficial if recommender systems of different organisations with similar nature can cooperate together to share their resources and recommendations. In this chapter, we present an Ecommerce-oriented Distributed Recommender System (EDRS) that consists of multiple recommender systems from different organisations. By sharing resources and recommendations with each other, these recommenders in the distributed recommendation system can provide better recommendation service to their users. As for most of the distributed systems, peer selection is often an important aspect. This chapter also presents a recommender selection technique for the proposed EDRS, and it selects and profiles recommenders based on their stability, average performance and selection frequency. Based on our experiments, it is shown that recommenders' recommendation quality can be effectively improved by adopting the proposed EDRS and the associated peer selection technique.

  7. Cohesion Based Personalized Community Recommendation System

    Directory of Open Access Journals (Sweden)

    Md Mamunur Rashid

    2016-08-01

    Full Text Available Our life is totally engaged by the progressive growth of online social networking. Because, millions of users are interconnecting with each other using different social media sites like Facebook, Twitter, LinkedIn, Google+, Pinterest, Instagram etc. Most of the social sites like Facebook, Google+ allow users to join different groups or communities where people can share their common interests and express opinions around a common cause, problem or activity. However, an information overloading issue has disturbed users as thousands of communities or groups are creating each day. To resolve this problem, we have presented a community or group recommendation system centered on cohesion where cohesion represents high degree of connectedness among users in social network. In this paper, we emphasis on suggesting useful communities (or groups in term of Facebook that users personally attracted in to join; reducing the effort to find useful information based on cohesion. Our projected framework contains of the steps like: extracting sub-network from a social networking site (SNS, computing the impact of amity(both real-life or social and SNS connected, measuring user proclivity factor, calculating threshold from existing communities or groups of a user and lastly recommending community or group based on derived threshold. In result analysis part, we consider the precision-recall values by discarding community or group one at a time from the list of communities or groups of a certain user and checking whether the removed community or group is recommended by our proposed system. We have evaluated our system with 20 users and found 76% F1 accuracy measure.

  8. Recommender systems in knowledge-mining

    Science.gov (United States)

    Volna, Eva

    2017-07-01

    The subject of the paper is to analyse the possibilities of application of recommender systems in the field of data mining. The work focuses on three basic types of recommender systems (collaborative, content-based and hybrid). The goal of the article is to evaluate which of these three concepts of recommender systems provides forecast with the lowest error rate in the domain of recommending movies. This target is fulfilled by the practical part of the work - at first, the own recommender system was designed and created, capable of obtaining movies recommendation from the database based on the user's preferences. Next, we verified experimentally which recommender system produces more accurate results.

  9. European recommendations for antimicrobial resistance surveillance.

    Science.gov (United States)

    Cornaglia, G; Hryniewicz, W; Jarlier, V; Kahlmeter, G; Mittermayer, H; Stratchounski, L; Baquero, F

    2004-04-01

    The problem of antimicrobial resistance surveillance in Europe has been debated extensively in many excellent documents issued by national committees that often assume the value of national guidelines. However, a comprehensive document addressing the whole matter from a European perspective, as well as reviewing its present status and drafting future perspectives, has been lacking. The present recommendations have been produced by the ESCMID Study Group for Antimicrobial Resistance Surveillance (ESGARS) through a consensus process involving all members of the Study Group. The recommendations focus on the detection of bacterial resistance and its reporting to clinicians, public health officers and a wider-and ever-increasing-audience. The leading concept is that the basis for resistance monitoring is microbiological diagnostics. The prerequisites for resistance monitoring are findings of adequate quality and quantity, which have been recorded properly and evaluated correctly. Different types of surveillance studies should fulfil different requirements with regard to data collection and reporting, the expected use of data, and the prerequisites for networking such activities. To generate relevant indicators, bacterial resistance data should be reported using adequate denominators and stratification. Reporting of antimicrobial resistance data is necessary for selection of empirical therapy at the local level, for assessing the scale of the resistance problem at the local, national or international levels, for monitoring changes in resistance rates, and for detecting the emergence and spread of new resistances types. Any type of surveillance study should conclude, where appropriate, with a proposal for intervention based on the data obtained.

  10. Recommender Systems by means of Information Retrieval

    CERN Document Server

    Costa, Alberto

    2010-01-01

    In this paper we present a method for reformulating the Recommender Systems problem in an Information Retrieval one. In our tests we have a dataset of users who give ratings for some movies; we hide some values from the dataset, and we try to predict them again using its remaining portion (the so-called "leave-n-out approach"). In order to use an Information Retrieval algorithm, we reformulate this Recommender Systems problem in this way: a user corresponds to a document, a movie corresponds to a term, the active user (whose rating we want to predict) plays the role of the query, and the ratings are used as weigths, in place of the weighting schema of the original IR algorithm. The output is the ranking list of the documents ("users") relevant for the query ("active user"). We use the ratings of these users, weighted according to the rank, to predict the rating of the active user. We carry out the comparison by means of a typical metric, namely the accuracy of the predictions returned by the algorithm, and we...

  11. Recommended vaccines for international travelers to India.

    Science.gov (United States)

    Verma, Ramesh; Khanna, Pardeep; Chawla, Suraj

    2015-01-01

    India's tourism industry generated 6.6% of the nation's Gross Domestic Product (GDP) during 2012. International travel to India is predicted to grow at an average annual rate of ∼ 8% over the next decade. The number of foreign tourists has increased by 9% to 5.8 million. Approximately 8% of travelers to developing countries require medical care during or after travel; the main diagnoses are vaccine-preventable diseases. Travelers to India can be exposed to various infectious diseases; water-borne, water-related, and zoonotic diseases may be imported to India where the disease is not endemic. The World Health Organization (WHO) emphasizes that all international travelers should be up to date with routine vaccinations. The recommended vaccinations for travelers to India vary according to the traveler's age, immunization history, existing medical conditions, duration, legal requirements for entry into countries being visited, travelers preferences, and values. Travelers should consult with a doctor so that there is sufficient time for completion of optimal vaccination schedules. No matter where traveling, one should be aware of potential exposure to certain organisms that can cause severely illnesses, even death. There is no doubt that vaccines have reduced or virtually eliminated many diseases that killed or severely disabled children and adults just a few generations ago. Thus, travelers must take recommended vaccines per schedule before traveling to India.

  12. Research of intelligent recommendation for mobile reading

    Science.gov (United States)

    Li, Qu

    2013-07-01

    Mobile reading is the trend of current publishing industry. Intelligent Recommendation system is useful and profitable for mobile reading platforms. Currently, intelligent recommendation systems mainly focus on news recommendation or production recommendation in e-commerce. In this paper, we designed and implemented an intelligent recommendation system based on slope one algorithm. Results show that our algorithm can help the users to find their interested books and thus greatly improve the income of mobile reading platform.

  13. Physical Exercise and MS Recommendations

    DEFF Research Database (Denmark)

    Dalgas, U; Ingemann-Hansen, T; Stenager, E

    2009-01-01

    The use of physical exercise programmes in the rehabilitation of patients with multiple sclerosis (MS) has been a controversial issue for many years. During the last decade, however, evidence from a number of studies has suggested that exercise is a safe and efficient way to induce improvements...... in a number of physiological functions, which ultimately can lead to functional improvements that have a positive effect on a patients daily life. The purpose of this review is, based on the existing research, to provide clinicians with some easily administrable recommendations for the application of exercise...

  14. Clinical recommendation: pediatric lichen sclerosus.

    Science.gov (United States)

    Bercaw-Pratt, Jennifer L; Boardman, Lori A; Simms-Cendan, Judith S

    2014-04-01

    Lichen sclerosus is a chronic inflammatory condition affecting the anogenital region that may present in the prepubertal or adolescent patient. Clinical presentations include significant pruritus, labial adhesions, and loss of pigmentation. Treatment includes topical anti-inflammatory agents and long-term follow-up as there is a high risk of recurrence and an increased risk of vulvar cancer in adult women with history of lichen sclerosus. These recommendations are intended for pediatricians, gynecologists, nurse practitioners and others who care for pediatric/adolescent girls in order to facilitate diagnosis and treatment.

  15. Dietetic recommendations in rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    María Rosa Alhambra-Expósito

    2013-12-01

    Full Text Available Rheumatoid arthritis (RA is a chronic autoimmune disease that has a significant effect on patients’ physical, emotional, and social functioning. For decades, patients have used different diets to try to improve the symptoms of RA. The possible benefits of dietary therapy for rheumatoid arthritis are reviewed in this article. Nutritional objectives for RA, are to halt the loss of bone mass, promote healing of bone fractures and improving bone-associated inflammatory disorders and joints. In general, diets low in saturated fat, rich in polyunsaturated fats: omega 3 and omega 6, rich in complex carbohydrates and fiber are recommended.

  16. WRS: The Wikipedia Recommender System

    Science.gov (United States)

    Lefévre, Thomas; Jensen, Christian Damsgaard; Korsgaard, Thomas Rune

    In 2005, the Wikipedia became the most popular reference website on the Internet and it has continued to grow in size and popularity ever since. With the increasing reliance on the Wikipedia comes issues of the credibility and provenance of content. In order to address these issues, we have developed a Recommender System for the Wikipedia, which allows the users of the Wikipedia to rate articles in order to guide other users about the quality of articles. This rating system provides both an incentive for authors to improve articles and a quantifiable measure of the perceived quality of articles.

  17. Fair Value or Market Value?

    OpenAIRE

    Bogdan Cosmin Gomoi; Lavinia Denisia Cuc; Robert Almaşi

    2014-01-01

    When taking into consideration the issue of defining the “fair value” concept, those less experimented in the area often fall in the “price trap”, which is considered as an equivalent of the fair value of financial structures. This valuation basis appears as a consequence of the trial to provide an “accurate image” by the financial statements and, also, as an opportunity for the premises offered by the activity continuing principle. The specialized literature generates ample controversies reg...

  18. Analysis and recommendations for DPA calculations in SiC

    Energy Technology Data Exchange (ETDEWEB)

    Heinisch, H.L. [Pacific Northwest National Lab., Richland, WA (United States)

    1998-09-01

    Recent modeling results, coupled with the implications of available experimental results, provide sufficient information to achieve consensus on the values of threshold displacement energies to use in displacements per atom (DPA) calculations. The values recommended here, 20 eV for C and 35 eV for Si, will be presented for adoption by the international fusion materials community at the next IEA SiC/SiC workshop.

  19. Ontological Matchmaking in Recommender Systems

    CERN Document Server

    Bonifati, Angela; Sileo, Domenica; Summa, Gianvito

    2010-01-01

    The electronic marketplace offers great potential for the recommendation of supplies. In the so called recommender systems, it is crucial to apply matchmaking strategies that faithfully satisfy the predicates specified in the demand, and take into account as much as possible the user preferences. We focus on real-life ontology-driven matchmaking scenarios and identify a number of challenges, being inspired by such scenarios. A key challenge is that of presenting the results to the users in an understandable and clear-cut fashion in order to facilitate the analysis of the results. Indeed, such scenarios evoke the opportunity to rank and group the results according to specific criteria. A further challenge consists of presenting the results to the user in an asynchronous fashion, i.e. the 'push' mode, along with the 'pull' mode, in which the user explicitly issues a query, and displays the results. Moreover, an important issue to consider in real-life cases is the possibility of submitting a query to multiple p...

  20. Personalized Social Recommendations - Accurate or Private?

    CERN Document Server

    Machanavajjhala, Ashwin; Sarma, Atish Das

    2011-01-01

    With the recent surge of social networks like Facebook, new forms of recommendations have become possible - personalized recommendations of ads, content, and even new friend and product connections based on one's social interactions. Since recommendations may use sensitive social information, it is speculated that these recommendations are associated with privacy risks. The main contribution of this work is in formalizing these expected trade-offs between the accuracy and privacy of personalized social recommendations. In this paper, we study whether "social recommendations", or recommendations that are solely based on a user's social network, can be made without disclosing sensitive links in the social graph. More precisely, we quantify the loss in utility when existing recommendation algorithms are modified to satisfy a strong notion of privacy, called differential privacy. We prove lower bounds on the minimum loss in utility for any recommendation algorithm that is differentially private. We adapt two priv...

  1. Valuing hope.

    Science.gov (United States)

    McMillan, John; Walker, Simon; Hope, Tony

    2014-01-01

    This article argues that hope is of value in clinical ethics and that it can be important for clinicians to be sensitive to both the risks of false hope and the importance of retaining hope. However, this sensitivity requires an understanding of the complexity of hope and how it bears on different aspects of a well-functioning doctor-patient relationship. We discuss hopefulness and distinguish it, from three different kinds of hope, or 'hopes for', and then relate these distinctions back to differing accounts of autonomy. This analysis matters because it shows how an overly narrow view of the ethical obligations of a clinician to their patient, and autonomy, might lead to scenarios where patients regret the choices they make.

  2. Fair Value or Market Value?

    Directory of Open Access Journals (Sweden)

    Bogdan Cosmin Gomoi

    2014-12-01

    Full Text Available When taking into consideration the issue of defining the “fair value” concept, those less experimented in the area often fall in the “price trap”, which is considered as an equivalent of the fair value of financial structures. This valuation basis appears as a consequence of the trial to provide an “accurate image” by the financial statements and, also, as an opportunity for the premises offered by the activity continuing principle. The specialized literature generates ample controversies regarding the “fair value” concept and the “market value” concept. The paper aims to debate this issue, taking into account various opinions.

  3. SYNTHETIC SLING FAILURE - EVALUATIONS & RECOMMENDATIONS

    Energy Technology Data Exchange (ETDEWEB)

    MACKEY TC; HENDERSON CS

    2009-10-26

    The information and evaluations provided in this report were compiled to address the recurring problem of synthetic sling failure. As safety is the number one priority in all work aspects, a solution must be devised to prevent accidents from occurring. A total of thirteen cases regarding synthetic sling failure were evaluated in order to determine their causes, effects, and preventative measures. From the collected data, it was found that all cases in which the synthetic sling contacted the edge of its load resulted in sling failure. It is required that adequate synthetic sling protection devices be used to protect slings in any lift where the sling comes in direct contact with the edge or corner of its load. However, there are no consensus codes or standards stating the type, material, or purpose of the type of protective device used to protect the sling from being cut. Numerous industry standards and codes provide vague descriptions on how to protect synthetic slings. Without a clear, concise statement of how to protect synthetic slings, it is common for inadequate materials and sling protection devices to be used in an attempt to meet the intent of these requirements. The use of an inadequate sling protection device is the main cause of synthetic sling failure in all researched cases. Commercial sling protection devices come in many shapes and sizes, and have a variety of names, as well as advertised uses. 'Abrasion pads' and 'wear protectors' are two different names for products with the same intended purpose. There is no distinguishable way to determine the extent of sling protection which these devices will provide, or what specific scenarios they are made for. This creates room for error in a field where error is unacceptable. This report provides a recommended action for hoisting and rigging activities which require synthetic slings to contact a load, as well as recommended changes to industry standards which will benefit overall

  4. Valuing vaccination

    Science.gov (United States)

    Bärnighausen, Till; Bloom, David E.; Cafiero-Fonseca, Elizabeth T.; O’Brien, Jennifer Carroll

    2014-01-01

    Vaccination has led to remarkable health gains over the last century. However, large coverage gaps remain, which will require significant financial resources and political will to address. In recent years, a compelling line of inquiry has established the economic benefits of health, at both the individual and aggregate levels. Most existing economic evaluations of particular health interventions fail to account for this new research, leading to potentially sizable undervaluation of those interventions. In line with this new research, we set forth a framework for conceptualizing the full benefits of vaccination, including avoided medical care costs, outcome-related productivity gains, behavior-related productivity gains, community health externalities, community economic externalities, and the value of risk reduction and pure health gains. We also review literature highlighting the magnitude of these sources of benefit for different vaccinations. Finally, we outline the steps that need to be taken to implement a broad-approach economic evaluation and discuss the implications of this work for research, policy, and resource allocation for vaccine development and delivery. PMID:25136129

  5. N-glycosylation increases the circulatory half-life of human growth hormone

    DEFF Research Database (Denmark)

    Flintegaard, Thomas V; Thygesen, Peter; Rahbek-Nielsen, Henrik

    2010-01-01

    Therapeutic use of recombinant GH typically involves daily sc injections. We examined the possibilities for prolonging the in vivo circulation of GH by introducing N-glycans. Human GH variants with a single potential N-glycosylation site (N-X-S/T) introduced by site-directed mutagenesis were...

  6. Endogenous compounds labeled with radionuclides of short half-life-some perspectives

    DEFF Research Database (Denmark)

    Roland Långström, Bengt; Karimi, F; Watanabe, Y

    2013-01-01

    In the article, the strategy and synthesis of some endogenous compounds labeled mainly with (11) C are presented. There are some examples illustrating how endogenous labeled compounds in connection with positron emission tomography have unique properties to describe various biological processes......, and a few examples of the use of tracers labeled with (13) N and (15) O are also discussed. Labeled endogenous compounds may be an important asset to describe the conditions and the status of biological systems and might therefore be a key for the future search of individualized medicine....

  7. The mysteriously variable half-life of dissolved organic matter in aquatic ecosystems: artefact or insight?

    Science.gov (United States)

    Evans, Chris; Fovet, Ophelie; Jones, Tim; Jones, Davey; Moldan, Filip; Futter, Martyn

    2016-04-01

    Dissolved organic matter (DOM) fluxes from land to water represent an important loss term in the terrestrial carbon balance, a major pathway in the global carbon cycle, a significant influence on aquatic light, nutrient and energy regimes, and an important concern for drinking water production. Although freshwaters are now recognised as zones of active carbon cycling, rather than passive conduits for carbon transport, evidence regarding the magnitude of, and controls on, DOM cycling in aquatic systems is incomplete and in some cases seemingly contradictory, with DOM 'half-lives' ranging from a few days to many years. Bringing together experimental, isotopic, catchment mass balance and modelling data, we suggest that apparently conflicting results can be reconciled through understanding of differences in: i) the terrestrial sources of DOM within heterogeneous landscapes, and consequent differences in its reactivity and stoichiometry; ii) experimental methodologies (i.e. which reactions are actually being measured), and iii) the extent of prior transformation of DOM upstream of the point of study. We argue that rapid photo-degradation, particularly of peat-derived DOM, is a key process in headwaters, whilst apparently slow DOM turnover in downstream, agriculturally-influenced lakes and rivers can partly be explained by the offsetting effect of in situ DOM production. This production appears to be strongly constrained by nutrient supply, thus linking DOM turnover and composition to the supply of inorganic nutrient inputs from diffuse agricultural pollution, and also providing a possible mechanistic link between aquatic DOM production and terrestrial DOM breakdown via the mineralisation and re-assimilation of organic nutrients. A more complete conceptual understanding of these interlinked processes will provide an improved understanding of the sources and fate of aquatic DOM, its role in the global carbon cycle, and the impact of anthropogenic activities, for example in relation to drinking water supplies and land management.

  8. Surfactant phosphatidylcholine half-life and pool size measurements in premature baboons developing bronchopulmonary dysplasia

    NARCIS (Netherlands)

    D.J. Janssen; V.P. Carnielli (Virgilio); P.E. Cogo (Paola); S.R. Seidner; I.H.I. Luijendijk; J.L.D. Wattimena (Josias); A.H. Jobe (Alan); L.J.I. Zimmermann (Luc)

    2002-01-01

    textabstractBecause minimal information is available about surfactant metabolism in bronchopulmonary dysplasia, we measured half-lives and pool sizes of surfactant phosphatidylcholine in very preterm baboons recovering from respiratory distress syndrome and developing

  9. Half-Life Learning Curves in the Defense Acquisition Life Cycle

    Science.gov (United States)

    2012-07-01

    learning include Smith (1989); Belkaoui (1976, 1986); Nanda (1979); Pegels (1976); Richardson (1978); Towill, and Kaloo (1978); Womer (1979, 1981, 1984...analysis adjusted for learning. Management Science, 24(2), 149–160. Nanda , R. (1979). Using learning curves in integration of production resources

  10. "半条命"当选最佳%Half-Life 2 Voted Best

    Institute of Scientific and Technical Information of China (English)

    张静

    2003-01-01

    @@ As much as Hollywood critics tend to spurn(弃绝)movies involving exploding zombies(巫毒崇拜), video game critics appear to love them. A game centered on the adventures of a scientist who blasts( 毁灭 ) an invading army of zombies has bested a field of rival offerings-including a driving adventure and a game first developed as a U. S. Army training tool-to win a coveted(觊觎的) award from game commentators.

  11. The half-life of the moral dilemma task : A case study in experimental (neuro-) philosophy

    NARCIS (Netherlands)

    Schleim, Stephan; Clausen, Jens; Levy, Neil

    2015-01-01

    The pioneering neuroscience of moral decisions studies implementing the moral dilemma task by Joshua Greene and colleagues stimulated interdisciplinary experimental research on moral cognition as well as a philosophical debate on its normative implications. This chapter emphasizes the influence thes

  12. The half-life of the moral dilemma task : A case study in experimental (neuro-) philosophy

    NARCIS (Netherlands)

    Schleim, Stephan; Clausen, Jens; Levy, Neil

    2015-01-01

    The pioneering neuroscience of moral decisions studies implementing the moral dilemma task by Joshua Greene and colleagues stimulated interdisciplinary experimental research on moral cognition as well as a philosophical debate on its normative implications. This chapter emphasizes the influence

  13. Systematics of alpha decay half-life: new evaluations for alpha-emitter nuclides

    Energy Technology Data Exchange (ETDEWEB)

    Medeiros, E.L.; Rodrigues, M.M.N.; Duarte, S.B.; Tavares, O.A.P. E-mail: emil.cbpf.br

    2006-06-15

    A semiempirical model based on the quantum mechanical tunnelling mechanism of alpha emission from nuclei has been used to systematize the alpha decay half-lives of a set of 336 nuclides, comprising all the alpha-emitter nuclides whose T{sub 1/2} {sup a}lpha-data for ground-state to ground-state transitions of mutual angular momentum l = 0 are known. With a minimum of data rejection (only {approx} 5% of cases), the procedure has been successful in reproducing quite satisfactorily (within a factor {approx} 2) most of the cases ({approx} 80%) investigated. The few significant discrepancies found between measured and calculated results are analysed and discussed. Also reported is the prediction from the model for possible new alpha-emitter nuclides, namely {sup 180} W, {sup 184} Os, and {sup 228} Ra for which cases the calculated partial alpha decay half-lives fall within the range of half-lives measurable by the current techniques. (author)

  14. Focus on the legislative approach to short half life radioactive hospital waste releasing.

    Science.gov (United States)

    Petrucci, Caterina; Traino, Antonio Claudio

    2015-11-01

    We propose to summarize the advancements introduced by the new Directive 2013/59/Euratom concerning the concept of clearance, for which the radioactive medical waste represents a typical candidate. We also intend to spotlight disputable points in the regulatory scheme in force in Italy, as well to make a contribution to evaluate whether the practice of patients' urine storing, stated by it, can be regarded to be proper. With directing our interest to radionuclides used in Nuclear Medicine, we first present an overview of how the clearance concept, and that of exemption closely related to it, have been developed from the previous Directive 96/29 to the new one; then we describe the implementation of these concepts in the Italian legislation. Subsequently we estimate the exposure due both to keeping the effluent on site and to direct discharging it to the environment. In line with a well established international consensus, the Directive 2013/59 drives simple and harmonized regulation of clearance. On the contrary, some complexity and lack of consistency can be found in the framework of the national legislation affecting the radioactive medical waste handling. In addition the practice of excreta storing is disputed not to be really beneficial. The opportunity should be taken to make the whole system of these requirements simpler and more consistent and effective when it is revised to transpose the new Directive. Copyright © 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

  15. Can soda fountains be recommended in hospitals?

    Science.gov (United States)

    Chaberny, Iris F; Kaiser, Peter; Sonntag, Hans-Günther

    2006-09-01

    Mineral water (soda water) is very popular in Germany. Therefore, soda fountains were developed as alternatives to the traditional deposit bottle system. Nowadays, different systems of these devices are commercially available. For several years, soda fountains produced by different companies have been examined at the University Hospital of Heidelberg. In 1998, it was possible for the first time to observe and evaluate one of these systems over a period of 320 days in a series of microbiological examinations. The evaluation was implemented on the basis of the German drinking water regulation (Anonymous, 1990. Gesetz über Trinkwasser und Wasser für Lebensmittelbetriebe (Trinkwasserverordnung - TrinkwV) vom 12. Dezember 1990. Bundesgesetzblatt 66, 2613ff). Initially, the bacteria counts exceeded the reference values imposed by the German drinking water regulation in almost 50% of the analyses. Pseudomonas aeruginosa was also detected in almost 38% of the samples. After a re-arrangement of the disinfection procedure and the removal of the charcoal filter, Pseudomonas aeruginosa was not detectable any more. However, the bacteria counts still frequently exceeded the reference values of the German drinking water regulation. Following our long-term analysis, we would not recommend soda fountains in high-risk areas of hospitals. If these devices are to be used in hospitals, the disinfection procedures should be executed in weekly or fortnightly intervals and the water quality should be examined periodically.

  16. A Survey Paper on Recommender Systems

    CERN Document Server

    Almazro, Dhoha; Albdulkarim, Lamia; Kherees, Mona; Martinez, Romy; Nzoukou, William

    2010-01-01

    Recommender systems apply data mining techniques and prediction algorithms to predict users' interest on information, products and services among the tremendous amount of available items. The vast growth of information on the Internet as well as number of visitors to websites add some key challenges to recommender systems. These are: producing accurate recommendation, handling many recommendations efficiently and coping with the vast growth of number of participants in the system. Therefore, new recommender system technologies are needed that can quickly produce high quality recommendations even for huge data sets. To address these issues we have explored several collaborative filtering techniques such as the item based approach, which identify relationship between items and indirectly compute recommendations for users based on these relationships. The user based approach was also studied, it identifies relationships between users of similar tastes and computes recommendations based on these relationships. In...

  17. Treatment of psoriatic arthritis: management recommendations.

    Science.gov (United States)

    Gossec, Laure; Smolen, Josef S

    2015-01-01

    Given the varied therapeutic options available for the management of psoriatic arthritis (PsA), recommendations for the management of PsA have been developed by several expert groups. These recommendations deal mainly with pharmacological treatments. At the international level, 2 recommendations sets are available: these have been developed by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and by the European League against Rheumatism (EULAR). These recommendations were published in 2009 and in 2012, respectively; and updates of these recommendations are currently ongoing. The first sets of recommendations dealt with non-steroidal anti-inflammatory drugs, glucocorticoids, conventional synthetic disease modifying drugs and tumour necrosis factor inhibitors; the 2015 sets of recommendations also deal with new drugs with other mechanisms of action, namely ustekinumab, secukinumab and apremilast. In the present paper, we will review these management recommendations.

  18. Back Bay Wilderness study : Proposed recommendations

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a list of recommendations for the proposed wilderness area on the Back Bay National Wildlife Refuge. The recommendations come as a result of the...

  19. On Differentially Private Online Collaborative Recommendation Systems

    OpenAIRE

    Gilbert, Seth; Liu, Xiao; Yu, Haifeng

    2015-01-01

    In collaborative recommendation systems, privacy may be compromised, as users' opinions are used to generate recommendations for others. In this paper, we consider an online collaborative recommendation system, and we measure users' privacy in terms of the standard differential privacy. We give the first quantitative analysis of the trade-offs between recommendation quality and users' privacy in such a system by showing a lower bound on the best achievable privacy for any non-trivial algorith...

  20. Personalized recommendation against crowd's popular selection

    CERN Document Server

    Zhu, Xuzhen; Liu, Haifeng

    2014-01-01

    The problem of personalized recommendation in an ocean of data attracts more and more attention recently. Most traditional researches ignore the popularity of the recommended object, which resulting in low personality and accuracy. In this Letter, we proposed a personalized recommendation method based on weighted object network, punishing the recommended object that is the crowd's popular selection, namely, Anti-popularity index(AP), which can give enhanced personality, accuracy and diversity in contrast to mainstream baselines with a low computational complexity.

  1. Panorama of Recommender Systems to Support Learning

    NARCIS (Netherlands)

    Drachsler, Hendrik; Verbert, Katrien; Santos, Olga C.; Manouselis, Nikos

    2015-01-01

    This chapter presents an analysis of recommender systems in TechnologyEnhanced Learning along their 15 years existence (2000-2014). All recommender systems considered for the review aim to support educational stakeholders by personalising the learning process. In this meta-review 82 recommender syst

  2. 5 CFR 2638.506 - Director's recommendation.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Director's recommendation. 2638.506... Cases Involving Individual Executive Agency Employees § 2638.506 Director's recommendation. (a) Where... employee is the head of an agency, the Director shall make any such recommendation to the President and...

  3. 22 CFR 909.3 - Board recommendation.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Board recommendation. 909.3 Section 909.3 Foreign Relations FOREIGN SERVICE GRIEVANCE BOARD DECISIONMAKING § 909.3 Board recommendation. Where the Board's decision is a recommendation, it shall be directed to the head of the Agency. A copy of...

  4. 7 CFR 1.420 - Consent recommendation.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Consent recommendation. 1.420 Section 1.420... Conservation and Shortage Relief Act of 1990 (16 U.S.C. 620 et seq.) § 1.420 Consent recommendation. Any time before the Judge files the decision, the parties of record may enter a consent recommendation....

  5. Cryptographically-enhanced privacy for recommender systems

    NARCIS (Netherlands)

    Jeckmans, Adrianus Johannus Paulus

    2014-01-01

    Automated recommender systems are used to help people find interesting content or persons in the vast amount of information available via the internet. There are different types of recommender systems, for example collaborative filtering systems and content-based recommender systems. However, all re

  6. Epilepsy surgery: Recommendations for India

    Directory of Open Access Journals (Sweden)

    Chandra P

    2010-01-01

    Full Text Available The following article recommends guidelines for epilepsy surgery for India. This article reviews the indications, the various surgical options available and the outcome of surgery for drug resistant epilepsy based on current evidence. Epilepsy surgery is a well-established option for patients who have been diagnosed to have drug resistant epilepsy (DRE (on at least two appropriate, adequate anti-epileptic drugs (AEDs (either in monotherapy or in combination with continuing seizures, where the presurgical work-up has shown concordance of structural imaging (magnetic resonance imaging and electrical mapping data (electroencephalography (EEG, video EEG. There may be a requirement of functional imaging techniques in a certain number of DRE like positron emission tomography (PET, single photon emission tomography, (SPECT. Invasive monitoring should be restricted to a few when all noninvasive investigations are inconclusive, there is a dual pathology or there is a discordance of noninvasive data. The types of surgery could be curative (resective surgeries: amygdalo hippocampectomy, lesionectomy and multilobar resections; functional surgeries: hemispherotomy and palliative (multiple subpial transaction, corpus callosotomy, vagal nerve stimulation. Epilepsy surgery in indicated cases has a success range from 50 to 86% in achieving seizure freedom as compared with < 5% success rate with AEDs only in persons with DRE. Centers performing surgery should be categorized into Level I and Level II.

  7. Nutritional recommendations for synchronized swimming.

    Science.gov (United States)

    Robertson, Sherry; Benardot, Dan; Mountjoy, Margo

    2014-08-01

    The sport of synchronized swimming is unique, because it combines speed, power, and endurance with precise synchronized movements and high-risk acrobatic maneuvers. Athletes must train and compete while spending a great amount of time underwater, upside down, and without the luxury of easily available oxygen. This review assesses the scientific evidence with respect to the physiological demands, energy expenditure, and body composition in these athletes. The role of appropriate energy requirements and guidelines for carbohydrate, protein, fat, and micronutrients for elite synchronized swimmers are reviewed. Because of the aesthetic nature of the sport, which prioritizes leanness, the risks of energy and macronutrient deficiencies are of significant concern. Relative Energy Deficiency in Sport and disordered eating/eating disorders are also of concern for these female athletes. An approach to the healthy management of body composition in synchronized swimming is outlined. Synchronized swimmers should be encouraged to consume a well-balanced diet with sufficient energy to meet demands and to time the intake of carbohydrate, protein, and fat to optimize performance and body composition. Micronutrients of concern for this female athlete population include iron, calcium, and vitamin D. This article reviews the physiological demands of synchronized swimming and makes nutritional recommendations for recovery, training, and competition to help optimize athletic performance and to reduce risks for weight-related medical issues that are of particular concern for elite synchronized swimmers.

  8. Vietnam recommended dietary allowances 2007.

    Science.gov (United States)

    Khan, Nguyen Cong; Hoan, Pham Van

    2008-01-01

    It has been well acknowledged that Vietnam is undergoing a nutrition transition. With a rapid change in the country's reform and economic growth, food supply at the macronutrient level has improved. Changes of the Vietnamese diet include significantly more foods of animal origin, and an increase of fat/oils, and ripe fruits. Consequently, nutritional problems in Vietnam now include not only malnutrition but also overweight/obesity, metabolic syndrome and other chronic diseases related to nutrition and lifestyles. The recognition of these shifts, which is also associated with morbidity and mortality, was a major factor in the need to review and update the Recommended Dietary Allowances (RDA) for the Vietnamese population. This revised RDA established an important science-based tool for evaluation of nutrition adequacy, for teaching, and for scientific communications within Vietnam. It is expected that the 2007 Vietnam RDA and its conversion to food-based dietary guidelines will facilitate education to the public, as well as the policy implementation of programs for prevention of non-communicable chronic diseases and addressing the double burden of both under and over nutrition.

  9. Recommendations for pathology peer review.

    Science.gov (United States)

    Morton, Daniel; Sellers, Rani S; Barale-Thomas, Erio; Bolon, Brad; George, Catherine; Hardisty, Jerry F; Irizarry, Armando; McKay, Jennifer S; Odin, Marielle; Teranishi, Munehiro

    2010-12-01

    Pathology peer review verifies and improves the accuracy and quality of pathology diagnoses and interpretations. Pathology peer review is recommended when important risk assessment or business decisions are based on nonclinical studies. For pathology peer review conducted before study completion, the peer-review pathologist reviews sufficient slides and pathology data to assist the study pathologist in refining pathology diagnoses and interpretations. Materials to be reviewed are selected by the peer-review pathologist. Consultations with additional experts or a formal (documented) pathology working group may be used to resolve discrepancies. The study pathologist is solely responsible for the content of the final pathology data and report, makes changes resulting from peer-review discussions, initiates the audit trail for microscopic observations after all changes resulting from peer-review have been made, and signs the final pathologist's report. The peer-review pathologist creates a signed peer-review memo describing the peer-review process and confirming that the study pathologist's report accurately and appropriately reflects the pathology data. The study pathologist also may sign a statement of consensus. It is not necessary to archive working notes created during the peer-review process.

  10. An Automated Recommender System for Course Selection

    Directory of Open Access Journals (Sweden)

    Amer Al-Badarenah

    2016-03-01

    Full Text Available Most of electronic commerce and knowledge management` systems use recommender systems as the underling tools for identifying a set of items that will be of interest to a certain user. Collaborative recommender systems recommend items based on similarities and dissimilarities among users’ preferences. This paper presents a collaborative recommender system that recommends university elective courses to students by exploiting courses that other similar students had taken. The proposed system employs an association rules mining algorithm as an underlying technique to discover patterns between courses. Experiments were conducted with real datasets to assess the overall performance of the proposed approach.

  11. Interest-based Recommendation in Digital Library

    Directory of Open Access Journals (Sweden)

    Yan Yang

    2005-01-01

    Full Text Available With the huge amount and large variety of information available in a digital library, it’s becoming harder and harder for users to identify and get hold of their interested documents. To alleviate the difficulty, personalized recommendation techniques have been developed. Current recommendation techniques rely on similarity between documents. In our work, recommendations are made based on three factors: similarity between documents, information amount, and information novelty. With the introduction of degree of interest, users’ interests can be better characterized. Theoretical analysis and experimental evaluations demonstrate that our techniques can improve both the recommendation recall and recommendation precision.

  12. Four simple recommendations to encourage best practices in research software

    Science.gov (United States)

    Jiménez, Rafael C.; Kuzak, Mateusz; Alhamdoosh, Monther; Barker, Michelle; Batut, Bérénice; Borg, Mikael; Capella-Gutierrez, Salvador; Chue Hong, Neil; Cook, Martin; Corpas, Manuel; Flannery, Madison; Garcia, Leyla; Gelpí, Josep Ll.; Gladman, Simon; Goble, Carole; González Ferreiro, Montserrat; Gonzalez-Beltran, Alejandra; Griffin, Philippa C.; Grüning, Björn; Hagberg, Jonas; Holub, Petr; Hooft, Rob; Ison, Jon; Katz, Daniel S.; Leskošek, Brane; López Gómez, Federico; Oliveira, Luis J.; Mellor, David; Mosbergen, Rowland; Mulder, Nicola; Perez-Riverol, Yasset; Pergl, Robert; Pichler, Horst; Pope, Bernard; Sanz, Ferran; Schneider, Maria V.; Stodden, Victoria; Suchecki, Radosław; Svobodová Vařeková, Radka; Talvik, Harry-Anton; Todorov, Ilian; Treloar, Andrew; Tyagi, Sonika; van Gompel, Maarten; Vaughan, Daniel; Via, Allegra; Wang, Xiaochuan; Watson-Haigh, Nathan S.; Crouch, Steve

    2017-01-01

    Scientific research relies on computer software, yet software is not always developed following practices that ensure its quality and sustainability. This manuscript does not aim to propose new software development best practices, but rather to provide simple recommendations that encourage the adoption of existing best practices. Software development best practices promote better quality software, and better quality software improves the reproducibility and reusability of research. These recommendations are designed around Open Source values, and provide practical suggestions that contribute to making research software and its source code more discoverable, reusable and transparent. This manuscript is aimed at developers, but also at organisations, projects, journals and funders that can increase the quality and sustainability of research software by encouraging the adoption of these recommendations. PMID:28751965

  13. Diffusion-like recommendation with enhanced similarity of objects

    Science.gov (United States)

    An, Ya-Hui; Dong, Qiang; Sun, Chong-Jing; Nie, Da-Cheng; Fu, Yan

    2016-11-01

    In the last decade, diversity and accuracy have been regarded as two important measures in evaluating a recommendation model. However, a clear concern is that a model focusing excessively on one measure will put the other one at risk, thus it is not easy to greatly improve diversity and accuracy simultaneously. In this paper, we propose to enhance the Resource-Allocation (RA) similarity in resource transfer equations of diffusion-like models, by giving a tunable exponent to the RA similarity, and traversing the value of this exponent to achieve the optimal recommendation results. In this way, we can increase the recommendation scores (allocated resource) of many unpopular objects. Experiments on three benchmark data sets, MovieLens, Netflix and RateYourMusic show that the modified models can yield remarkable performance improvement compared with the original ones.

  14. Board advice following publication of the 1990 Recommendations of ICRP

    CERN Document Server

    United Kingdom. At. Energy Res. Establ. Nat. Radiolog. Protect. Board. Harwell

    1991-01-01

    The International Commission on Radiological Protection (ICRP) has published new Recommendations and the board has a statutory duty to advise Government and those with responsibilities for radiation protection on the acceptability to and the applicability in the UK of those Recommendations. The Board wishes to consult widely before finalising the advice which is proposed in this document. In general, the Board endorses the conceptual framework for radiological protection recommended by ICRP. In particular, the distinction between practices and intervention is useful and is consistent with the way in which the Board has presented its recent advice. A major new concept is that of a constraint. The Board believes that the introduction of constraints provides a powerful method for improving protection against ionising radiation. The advice in this consultative document is for maximum generic values of dose constraints for both workers and the public. Finally the Board proposes to endorse the use of the radiologic...

  15. Four simple recommendations to encourage best practices in research software.

    Science.gov (United States)

    Jiménez, Rafael C; Kuzak, Mateusz; Alhamdoosh, Monther; Barker, Michelle; Batut, Bérénice; Borg, Mikael; Capella-Gutierrez, Salvador; Chue Hong, Neil; Cook, Martin; Corpas, Manuel; Flannery, Madison; Garcia, Leyla; Gelpí, Josep Ll; Gladman, Simon; Goble, Carole; González Ferreiro, Montserrat; Gonzalez-Beltran, Alejandra; Griffin, Philippa C; Grüning, Björn; Hagberg, Jonas; Holub, Petr; Hooft, Rob; Ison, Jon; Katz, Daniel S; Leskošek, Brane; López Gómez, Federico; Oliveira, Luis J; Mellor, David; Mosbergen, Rowland; Mulder, Nicola; Perez-Riverol, Yasset; Pergl, Robert; Pichler, Horst; Pope, Bernard; Sanz, Ferran; Schneider, Maria V; Stodden, Victoria; Suchecki, Radosław; Svobodová Vařeková, Radka; Talvik, Harry-Anton; Todorov, Ilian; Treloar, Andrew; Tyagi, Sonika; van Gompel, Maarten; Vaughan, Daniel; Via, Allegra; Wang, Xiaochuan; Watson-Haigh, Nathan S; Crouch, Steve

    2017-01-01

    Scientific research relies on computer software, yet software is not always developed following practices that ensure its quality and sustainability. This manuscript does not aim to propose new software development best practices, but rather to provide simple recommendations that encourage the adoption of existing best practices. Software development best practices promote better quality software, and better quality software improves the reproducibility and reusability of research. These recommendations are designed around Open Source values, and provide practical suggestions that contribute to making research software and its source code more discoverable, reusable and transparent. This manuscript is aimed at developers, but also at organisations, projects, journals and funders that can increase the quality and sustainability of research software by encouraging the adoption of these recommendations.

  16. An Agent Framework of Tourism Recommender System

    Directory of Open Access Journals (Sweden)

    Jia Zhi Yang

    2016-01-01

    Full Text Available This paper proposes the development of an Agent framework for tourism recommender system. The recommender system can be featured as an online web application which is capable of generating a personalized list of preference attractions for tourists. Traditional technologies of classical recommender system application domains, such as collaborative filtering, content-based filtering and content-based filtering are effectively adopted in the framework. In the framework they are constructed as Agents that can generate recommendations respectively. Recommender Agent can generate recommender information by integrating the recommendations of Content-based Agent, collaborative filtering-based Agent and constraint-based Agent. In order to make the performance more effective, linear combination method of data fusion is applied. User interface is provided by the tourist Agent in form of webpages and mobile app.

  17. Persuasive Recommender Systems Conceptual Background and Implications

    CERN Document Server

    Yoo, Kyung-Hyan; Zanker, Markus

    2013-01-01

    Whether users are likely to accept the recommendations provided by a recommender system is of utmost importance to system designers and the marketers who implement them. By conceptualizing the advice seeking and giving relationship as a fundamentally social process, important avenues for understanding the persuasiveness of recommender systems open up. Specifically, research regarding influential factors in advice seeking relationships, which is abundant in the context of human-human relationships, can provide an important framework for identifying potential influence factors in recommender system context. This book reviews the existing literature on the factors in advice seeking relationships in the context of human-human, human-computer, and human-recommender system interactions. It concludes that many social cues that have been identified as influential in other contexts have yet to be implemented and tested with respect to recommender systems. Implications for recommender system research and design are dis...

  18. Hybrid recommendation methods in complex networks

    CERN Document Server

    Fiasconaro, A; Nicosia, V; Latora, V; Mantegna, R N

    2014-01-01

    We propose here two new recommendation methods, based on the appropriate normalization of already existing similarity measures, and on the convex combination of the recommendation scores derived from similarity between users and between objects. We validate the proposed measures on three relevant data sets, and we compare their performance with several recommendation systems recently proposed in the literature. We show that the proposed similarity measures allow to attain an improvement of performances of up to 20\\% with respect to existing non-parametric methods, and that the accuracy of a recommendation can vary widely from one specific bipartite network to another, which suggests that a careful choice of the most suitable method is highly relevant for an effective recommendation on a given system. Finally, we studied how an increasing presence of random links in the network affects the recommendation scores, and we found that one of the two recommendation algorithms introduced here can systematically outpe...

  19. Hybrid recommendation methods in complex networks

    Science.gov (United States)

    Fiasconaro, A.; Tumminello, M.; Nicosia, V.; Latora, V.; Mantegna, R. N.

    2015-07-01

    We propose two recommendation methods, based on the appropriate normalization of already existing similarity measures, and on the convex combination of the recommendation scores derived from similarity between users and between objects. We validate the proposed measures on three data sets, and we compare the performance of our methods to other recommendation systems recently proposed in the literature. We show that the proposed similarity measures allow us to attain an improvement of performances of up to 20% with respect to existing nonparametric methods, and that the accuracy of a recommendation can vary widely from one specific bipartite network to another, which suggests that a careful choice of the most suitable method is highly relevant for an effective recommendation on a given system. Finally, we study how an increasing presence of random links in the network affects the recommendation scores, finding that one of the two recommendation algorithms introduced here can systematically outperform the others in noisy data sets.

  20. Hybrid recommendation methods in complex networks.

    Science.gov (United States)

    Fiasconaro, A; Tumminello, M; Nicosia, V; Latora, V; Mantegna, R N

    2015-07-01

    We propose two recommendation methods, based on the appropriate normalization of already existing similarity measures, and on the convex combination of the recommendation scores derived from similarity between users and between objects. We validate the proposed measures on three data sets, and we compare the performance of our methods to other recommendation systems recently proposed in the literature. We show that the proposed similarity measures allow us to attain an improvement of performances of up to 20% with respect to existing nonparametric methods, and that the accuracy of a recommendation can vary widely from one specific bipartite network to another, which suggests that a careful choice of the most suitable method is highly relevant for an effective recommendation on a given system. Finally, we study how an increasing presence of random links in the network affects the recommendation scores, finding that one of the two recommendation algorithms introduced here can systematically outperform the others in noisy data sets.

  1. Human Genetic Engineering: A Survey of Student Value Stances

    Science.gov (United States)

    Wilson, Sara McCormack; And Others

    1975-01-01

    Assesses the values of high school and college students relative to human genetic engineering and recommends that biology educators explore instructional strategies merging human genetic information with value clarification techniques. (LS)

  2. Vitamin D recommendations, fortification in France, and communication

    Directory of Open Access Journals (Sweden)

    Dhaussy Amélie

    2014-05-01

    Full Text Available The vitamin D has recently been the subject of many researches, demonstrating new effects, reinforcing the interest for this molecule. The interest to develop products fortified with vitamin D is thus very important. Regarding references values, it is necessary to distinguish the RDAs (Recommended Daily Allowances, single value set up at 5 μg/d for vitamin D at the European level, in order to be a reference and a labeling value, from the nutritional recommendations. These recommendations are defined by groups of population. The values vary according to the countries and the dates on which they were set, the most recent being usually higher. The vitamin D fortification is less constrained in France today than before 2006. To fortify a food with vitamin D, it is necessary to follow the rules set by the Regulation 1925/2006/EC, and use the formulations authorized, demonstrate the nutritional benefit of the fortification, and ensure that the fortification does not lead to a risk for the health of the consumers. In some countries, the vitamin D fortification has been made mandatory for some foods. In France, several products are fortified with vitamin D, especially dairy products, but also some breakfast cereals and vegetable oils. Finally, the communication that can be made on vitamin D in food or advertising is strictly regulated by the Regulation 1924/2006/EC.

  3. Values Education and Some Suggestions to Teachers

    Science.gov (United States)

    Demirhan Iscan, Canay

    2011-01-01

    This paper focuses on the process, approaches and teacher roles in values education and offers recommendations for teachers. It uses print materials and Internet sources on values education. These sources were analyzed and synthesized to reveal certain cases and/or opinions. In addition to contemporary sources, older reference materials were also…

  4. NUTRITION FOR TENNIS: PRACTICAL RECOMMENDATIONS

    Directory of Open Access Journals (Sweden)

    Mayur K. Ranchordas

    2013-06-01

    Full Text Available Tennis is a pan-global sport that is played year-round in both hemispheres. This places notable demands on the physical and psychological preparation of players and included in these demands are nutritional and fluid requirements both of training and match- play. Thus, the purpose of this article is to review nutritional recommendations for tennis. Notably, tennis players do not excel in any particular physiological or anthropometric characteristic but are well adapted in all areas which is probably a result of the varied nature of the training demands of tennis match play. Energy expenditures of 30.9 ± 5.5 and 45.3 ± 7.3 kJ·min-1 have been reported in women and men players respectively regardless of court surface. Tennis players should follow a habitually high carbohydrate diet of between 6-10 g·kg-1·d-1 to ensure adequate glycogen stores, with women generally requiring slightly less than men. Protein intake guidelines for tennis players training at a high intensity and duration on a daily basis should be ~1.6 g·kg-1·d-1 and dietary fat intake should not exceed 2 g·kg-1·d-1. Caffeine in doses of 3 mg·kg-1 provides ergogenic benefit when taken before and/or during tennis match play. Depending on environmental conditions, sweat rates of 0.5 to and over 5 L·hr-1 and sodium losses of 0.5 - 1.8 g have been recorded in men and women players. 200 mL of fluid containing electrolytes should be consumed every change-over in mild to moderate temperatures of 400 mL. 30-60 g·hr-1 of carbohydrate should be ingested when match play exceeds 2 hours.

  5. Ambulatory Blood Pressure Monitoring – Clinical Practice Recommendations

    Directory of Open Access Journals (Sweden)

    Katalin Mako

    2016-09-01

    Full Text Available Ambulatory blood pressure monitoring (ABPM became a subject of considerable scientific interest. Due to the increasing use of the ABPM in everyday clinical practice it is important that all the users have a correct knowledge on the clinical indications, the methodology of using the device including some technical issues and the interpretation of results. In the last years several guidelines and position papers have been published with recommendations for the monitoring process, reference values, for clinical practice and research. This paper represents a summary of the most important aspects related to the use of ABPM in daily practice, being a synthesis of recommendations from the recent published guidelines and position papers. This reference article presents the practical and technical issues of ABPM, the use of this method in special situations, the clinical interpretation of measured values including the presentation of different ABPM patterns, derived parameters, the prognostic significance and the limitations of this method.

  6. Recommendation System Based on Fuzzy Cognitive Map

    Directory of Open Access Journals (Sweden)

    Wei Liu

    2014-07-01

    Full Text Available With the increase of data volume and visitor volume, the website faces great challenge in the environment of network. How to know the users’ requirements rapidly and effectively and recommend the required information to the user becomes the research direction of all websites. The researchers of recommendation system propose a series of recommendation system models and algorithms for the user. The common challenge faced by these algorithms is how to judge the user intention and recommend the relevant content by little user action. The paper proposes the user situation awareness and information recommendation system based on fuzzy clustering analysis and fuzzy cognitive maps, and verifies the validity of the algorithm by the application to recommendation site of academic thesis.

  7. Recommender Systems for the Social Web

    CERN Document Server

    Pazos Arias, José J; Díaz Redondo, Rebeca P

    2012-01-01

    The recommendation of products, content and services cannot be considered newly born, although its widespread application is still in full swing. While its growing success in numerous sectors, the progress of the  Social Web has revolutionized the architecture of participation and relationship in the Web, making it necessary to restate recommendation and reconciling it with Collaborative Tagging, as the popularization of authoring in the Web, and  Social Networking, as the translation of personal relationships to the Web. Precisely, the convergence of recommendation with the above Social Web pillars is what motivates this book, which has collected contributions from well-known experts in the academy and the industry to provide a broader view of the problems that Social Recommenders might face with.  If recommender systems have proven their key role in facilitating the user access to resources on the Web, when sharing resources has become social, it is natural for recommendation strategies in the Social Web...

  8. Network-based recommendation algorithms: A review

    CERN Document Server

    Yu, Fei; Gillard, Sebastien; Medo, Matus

    2015-01-01

    Recommender systems are a vital tool that helps us to overcome the information overload problem. They are being used by most e-commerce web sites and attract the interest of a broad scientific community. A recommender system uses data on users' past preferences to choose new items that might be appreciated by a given individual user. While many approaches to recommendation exist, the approach based on a network representation of the input data has gained considerable attention in the past. We review here a broad range of network-based recommendation algorithms and for the first time compare their performance on three distinct real datasets. We present recommendation topics that go beyond the mere question of which algorithm to use - such as the possible influence of recommendation on the evolution of systems that use it - and finally discuss open research directions and challenges.

  9. Network-based recommendation algorithms: A review

    Science.gov (United States)

    Yu, Fei; Zeng, An; Gillard, Sébastien; Medo, Matúš

    2016-06-01

    Recommender systems are a vital tool that helps us to overcome the information overload problem. They are being used by most e-commerce web sites and attract the interest of a broad scientific community. A recommender system uses data on users' past preferences to choose new items that might be appreciated by a given individual user. While many approaches to recommendation exist, the approach based on a network representation of the input data has gained considerable attention in the past. We review here a broad range of network-based recommendation algorithms and for the first time compare their performance on three distinct real datasets. We present recommendation topics that go beyond the mere question of which algorithm to use-such as the possible influence of recommendation on the evolution of systems that use it-and finally discuss open research directions and challenges.

  10. Kernel based collaborative recommender system for -purchasing

    Indian Academy of Sciences (India)

    M K Kavitha Devi; P Venkatesh

    2010-10-01

    Recommender system a new marketing strategy plays an important role particularly in an electronic commerce environment. Among the various recommender systems, collaborative recommender system (CRS) is widely used in a number of different applications such as recommending web pages, movies, tapes and items. CRS suffers from scalability, sparsity, and cold start problems. An intelligent integrated recommendation approach using radial basis function network (RBFN) and collaborative filtering (CF), based on Cover’s theorem, is proposed in order to overcome the traditional problems of CRS. The proposed system predicts the trend by considering both likes and dislikes of the active user. The empirical evaluation results reveal that the proposed approach is more effective than other existing approaches in terms of accuracy and relevance measure of recommendations.

  11. RECOMMENDER SYSTEMS IN E-COMMERCE APPLICATIONS

    Directory of Open Access Journals (Sweden)

    Gyöngyvér KOVÁCS

    2016-12-01

    Full Text Available One of the major problem with online shopping is finingd the right product, because finding the right product presumes that we know its name, but in most cases it is not so. For this reason the users need help in the process of online searching/shopping. Recommender systems have became a popular technique and strategy for helping users to select desirable products or services. In the past few years the recommender systems have changed from novelties used by a few big e-commerce sites, to serious business tools that are re-shaping the world of e-commerce. In this paper, we provide a brief overview of the classification of recommendation systems based on technology used to create recommendations, and inputs they need from the customers. Furthermore we analyze a few algorithms used by recommender systems and we will also present some marketing recommender systems and their comparative analysis.

  12. On the Evolution of Critiquing Recommenders

    Science.gov (United States)

    McGinty, Lorraine; Reilly, James

    Over the past decade a significant amount of recommender systems research has demonstrated the benefits of conversational architectures that employ critique-based interfacing (e.g., Show me more like item A, but cheaper). The critiquing phenomenon has attracted great interest in line with the growing need for more sophisticated decision/recommendation support systems to assist online users who are overwhelmed by multiple product alternatives. Originally proposed as a powerful yet practical solution to the preference elicitation problem central to many conversational recommenders, critiquing has proved to be a popular topic in a variety of related areas (e.g., group recommendation, mixed-initiative recommendation, adaptive user interfacing, recommendation explanation). This chapter aims to provide a comprehensive, yet concise, source of reference for researchers and practitioners starting out in this area. Specifically, we present a deliberately non-technical overview of the critiquing research which has been covered in recent years.

  13. Arterial Stiffness: Recommendations and Standardization

    Science.gov (United States)

    Townsend, Raymond R.

    2017-01-01

    The use of arterial stiffness measurements in longitudinal cohorts of normal populations, hypertensive patients, diabetic patients, healthy elderly, and patients on hemodialysis have confirmed the value of this important measure of arterial health, and established its complementary role to measures of blood pressure. Its contribution to understanding cardiovascular and mortality risk beyond blood pressure measurements has moved measures of arterial stiffness into the ranks of factors such as elevated cholesterol, diabetes, and left ventricular hypertrophy in considering cardiovascular risk. The recent international collaboration's publication of reference ranges for normal people and those with hypertension, along with the American Heart Association's recent scientific statement on standardizing arterial stiffness measurements are important aspects to consider in future studies employing these valuable methods, particularly as interventions that not only lower blood pressure but improve arterial function are tested in the clinical arena. PMID:28275588

  14. 2 × 2 Tables: a note on Campbell's recommendation.

    Science.gov (United States)

    Busing, F M T A; Weaver, B; Dubois, S

    2016-04-15

    For 2 × 2 tables, Egon Pearson's N - 1 chi-squared statistic is theoretically more sound than Karl Pearson's chi-squared statistic, and provides more accurate p values. Moreover, Egon Pearson's N - 1 chi-squared statistic is equal to the Mantel-Haenszel chi-squared statistic for a single 2 × 2 table, and as such, is often available in statistical software packages like SPSS, SAS, Stata, or R, which facilitates compliance with Ian Campbell's recommendations.

  15. DEVELOPING SAFETY INDICATORS ON THE BASIS OF THE ICAO RECOMMENDATIONS

    Directory of Open Access Journals (Sweden)

    V. D. Sharov

    2014-01-01

    Full Text Available The article offers direct use of the recommendations of SMM ICAO Doc.9859, 3rd ed. 2013, for calculation the target and alert levels of safety indicators. Examples of calculation based on data of 2011 and monitoring of the current indicators during 2012 are presented. Safety indicators for airlines in terms of “numbers of incidents per 1000 flight hours” could be calculated on the basis of the state values through the «coefficient of conformity».

  16. Privacy Preserving Recommendation System Based on Groups

    OpenAIRE

    Shang, Shang; Hui, Yuk; Hui, Pan; Cuff, Paul; Kulkarni, Sanjeev

    2013-01-01

    Recommendation systems have received considerable attention in the recent decades. Yet with the development of information technology and social media, the risk in revealing private data to service providers has been a growing concern to more and more users. Trade-offs between quality and privacy in recommendation systems naturally arise. In this paper, we present a privacy preserving recommendation framework based on groups. The main idea is to use groups as a natural middleware to preserve ...

  17. Recommendation advertising method based on behavior retargeting

    Science.gov (United States)

    Zhao, Yao; YIN, Xin-Chun; CHEN, Zhi-Min

    2011-10-01

    Online advertising has become an important business in e-commerce. Ad recommended algorithms are the most critical part in recommendation systems. We propose a recommendation advertising method based on behavior retargeting which can avoid leakage click of advertising due to objective reasons and can observe the changes of the user's interest in time. Experiments show that our new method can have a significant effect and can be further to apply to online system.

  18. Using social ties in group recommendation

    OpenAIRE

    Bourke, Steven; McCarthy, Kevin; Smyth, Barry

    2011-01-01

    The social web is a mass of activity, petabytes of data are generated yearly. The social web has proven to be a great resource for new recommender system techniques and ideas. However it would appear that typically these techniques are not so social, as they only generate recommendations for a user acting alone. In this paper we take the social graph data and preference content (via Facebook) of 94 user study participants and generate social group recommendations for them and their friends. W...

  19. TALYS/TENDL verification and validation processes: Outcomes and recommendations

    Science.gov (United States)

    Fleming, Michael; Sublet, Jean-Christophe; Gilbert, Mark R.; Koning, Arjan; Rochman, Dimitri

    2017-09-01

    The TALYS-generated Evaluated Nuclear Data Libraries (TENDL) provide truly general-purpose nuclear data files assembled from the outputs of the T6 nuclear model codes system for direct use in both basic physics and engineering applications. The most recent TENDL-2015 version is based on both default and adjusted parameters of the most recent TALYS, TAFIS, TANES, TARES, TEFAL, TASMAN codes wrapped into a Total Monte Carlo loop for uncertainty quantification. TENDL-2015 contains complete neutron-incident evaluations for all target nuclides with Z ≤116 with half-life longer than 1 second (2809 isotopes with 544 isomeric states), up to 200 MeV, with covariances and all reaction daughter products including isomers of half-life greater than 100 milliseconds. With the added High Fidelity Resonance (HFR) approach, all resonances are unique, following statistical rules. The validation of the TENDL-2014/2015 libraries against standard, evaluated, microscopic and integral cross sections has been performed against a newly compiled UKAEA database of thermal, resonance integral, Maxwellian averages, 14 MeV and various accelerator-driven neutron source spectra. This has been assembled using the most up-to-date, internationally-recognised data sources including the Atlas of Resonances, CRC, evaluated EXFOR, activation databases, fusion, fission and MACS. Excellent agreement was found with a small set of errors within the reference databases and TENDL-2014 predictions.

  20. TALYS/TENDL verification and validation processes: Outcomes and recommendations

    Directory of Open Access Journals (Sweden)

    Fleming Michael

    2017-01-01

    Full Text Available The TALYS-generated Evaluated Nuclear Data Libraries (TENDL provide truly general-purpose nuclear data files assembled from the outputs of the T6 nuclear model codes system for direct use in both basic physics and engineering applications. The most recent TENDL-2015 version is based on both default and adjusted parameters of the most recent TALYS, TAFIS, TANES, TARES, TEFAL, TASMAN codes wrapped into a Total Monte Carlo loop for uncertainty quantification. TENDL-2015 contains complete neutron-incident evaluations for all target nuclides with Z ≤116 with half-life longer than 1 second (2809 isotopes with 544 isomeric states, up to 200 MeV, with covariances and all reaction daughter products including isomers of half-life greater than 100 milliseconds. With the added High Fidelity Resonance (HFR approach, all resonances are unique, following statistical rules. The validation of the TENDL-2014/2015 libraries against standard, evaluated, microscopic and integral cross sections has been performed against a newly compiled UKAEA database of thermal, resonance integral, Maxwellian averages, 14 MeV and various accelerator-driven neutron source spectra. This has been assembled using the most up-to-date, internationally-recognised data sources including the Atlas of Resonances, CRC, evaluated EXFOR, activation databases, fusion, fission and MACS. Excellent agreement was found with a small set of errors within the reference databases and TENDL-2014 predictions.

  1. Uncovering the information core in recommender systems

    Science.gov (United States)

    Zeng, Wei; Zeng, An; Liu, Hao; Shang, Ming-Sheng; Zhou, Tao

    2014-08-01

    With the rapid growth of the Internet and overwhelming amount of information that people are confronted with, recommender systems have been developed to effectively support users' decision-making process in online systems. So far, much attention has been paid to designing new recommendation algorithms and improving existent ones. However, few works considered the different contributions from different users to the performance of a recommender system. Such studies can help us improve the recommendation efficiency by excluding irrelevant users. In this paper, we argue that in each online system there exists a group of core users who carry most of the information for recommendation. With them, the recommender systems can already generate satisfactory recommendation. Our core user extraction method enables the recommender systems to achieve 90% of the accuracy of the top-L recommendation by taking only 20% of the users into account. A detailed investigation reveals that these core users are not necessarily the large-degree users. Moreover, they tend to select high quality objects and their selections are well diversified.

  2. A Study about Personalized Content Recommendation

    Directory of Open Access Journals (Sweden)

    BRITO, J. F.

    2013-12-01

    Full Text Available Recommendation systems have been proposed as efficient strategies to deal with the information overload which is an Internet reality. In order to study personalized content recommendation, this paper aims at identifying and analyzing, systematically, methods and techniques adopted in the recommendation context. In the systematic review process, 22 papers have been accepted from the main digital databases in the area. The final results suggest a tendency in the use of strategies to reduce the limitations and to increase the efficiency of the recommendation methods.

  3. Web Page Recommendation Using Web Mining

    Directory of Open Access Journals (Sweden)

    Modraj Bhavsar

    2014-07-01

    Full Text Available On World Wide Web various kind of content are generated in huge amount, so to give relevant result to user web recommendation become important part of web application. On web different kind of web recommendation are made available to user every day that includes Image, Video, Audio, query suggestion and web page. In this paper we are aiming at providing framework for web page recommendation. 1 First we describe the basics of web mining, types of web mining. 2 Details of each web mining technique.3We propose the architecture for the personalized web page recommendation.

  4. ISFG: Recommendations on biostatistics in paternity testing.

    Science.gov (United States)

    Gjertson, David W; Brenner, Charles H; Baur, Max P; Carracedo, Angel; Guidet, Francois; Luque, Juan A; Lessig, Rüdiger; Mayr, Wolfgang R; Pascali, Vince L; Prinz, Mechthild; Schneider, Peter M; Morling, Niels

    2007-12-01

    The Paternity Testing Commission (PTC) of the International Society for Forensic Genetics has taken up the task of establishing the biostatistical recommendations in accordance with the ISO 17025 standards and a previous set of ISFG recommendations specific to the genetic investigations in paternity cases. In the initial set, the PTC recommended that biostatistical evaluations of paternity are based on a likelihood ratio principle - yielding the paternity index, PI. Here, we have made five supplementary biostatistical recommendations. The first recommendation clarifies and defines basic concepts of genetic hypotheses and calculation concerns needed to produce valid PIs. The second and third recommendations address issues associated with population genetics (allele probabilities, Y-chromosome markers, mtDNA, and population substructuring) and special circumstances (deficiency/reconstruction and immigration cases), respectively. The fourth recommendation considers strategies regarding genetic evidence against paternity. The fifth recommendation covers necessary documentation, reporting details and assumptions underlying calculations. The PTC strongly suggests that these recommendations should be adopted by all laboratories involved in paternity testing as the basis for their biostatistical analysis.

  5. ISFG: Recommendations on biostatistics in paternity testing

    DEFF Research Database (Denmark)

    Gjertson, David W; Brenner, Charles H; Baur, Max P

    2007-01-01

    The Paternity Testing Commission (PTC) of the International Society for Forensic Genetics has taken up the task of establishing the biostatistical recommendations in accordance with the ISO 17025 standards and a previous set of ISFG recommendations specific to the genetic investigations in patern......The Paternity Testing Commission (PTC) of the International Society for Forensic Genetics has taken up the task of establishing the biostatistical recommendations in accordance with the ISO 17025 standards and a previous set of ISFG recommendations specific to the genetic investigations...

  6. OMB Recommended vs Approved Operating Budget

    Data.gov (United States)

    Montgomery County of Maryland — This dataset includes the Fiscal Year 2015 County Executive Recommended and County Council Approved operating budgets for Montgomery County, for comparison purposes....

  7. Social Trust Aware Item Recommendation for Implicit Feedback

    Institute of Scientific and Technical Information of China (English)

    郭磊; 马军; 姜浩然; 陈竹敏; 邢长明

    2015-01-01

    Social trust aware recommender systems have been well studied in recent years. However, most of existing methods focus on the recommendation scenarios where users can provide explicit feedback to items. But in most cases, the feedback is not explicit but implicit. Moreover, most of trust aware methods assume the trust relationships among users are single and homogeneous, whereas trust as a social concept is intrinsically multi-faceted and heterogeneous. Simply exploiting the raw values of trust relations cannot get satisfactory results. Based on the above observations, we propose to learn a trust aware personalized ranking method with multi-faceted trust relations for implicit feedback. Specifically, we first introduce the social trust assumption — a user’s taste is close to the neighbors he/she trusts — into the Bayesian Personalized Ranking model. To explore the impact of users’ multi-faceted trust relations, we further propose a category-sensitive random walk method CRWR to infer the true trust value on each trust link. Finally, we arrive at our trust strength aware item recommendation method SocialBPRCRWR by replacing the raw binary trust matrix with the derived real-valued trust strength. Data analysis and experimental results on two real-world datasets demonstrate the existence of social trust influence and the effectiveness of our social based ranking method SocialBPRCRWR in terms of AUC (area under the receiver operating characteristic curve).

  8. Recommended values of the humidity correction factor k{sub n} for determining exposure in an X-ray beam with free-air chambers; Valores recomendados del factor de correccion por humedad, k{sub h} para la determinacion de la exposicion en un haz de rayos X usando camaras de paredes de aire

    Energy Technology Data Exchange (ETDEWEB)

    Los Arcos, J.M.; Brosed, A.

    1983-07-01

    The experimental values stated by CCEMRI (Section I) concerning the humidity correction factor k{sub h} required for determining exposure in an X-ray beam with free-air chambers are commented and a method to estimate k{sub n} numerically, at any particular combination of relative humidity, pressure and temperature, la explained. A table of k{sub h}, calculated for relative humidity varying from 0% to 90%, for pressures in the range of 70 kPa to 104kPa and temperatures between 15 degree centigree and 30 degree centigree, is included. (Author) 10 refs.

  9. 40 CFR 231.5 - Recommended determination.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended determination. 231.5... 404(c) PROCEDURES § 231.5 Recommended determination. (a) The Regional Administrator or his designee... public notice of the proposed determination, either withdraw the proposed determination or prepare a...

  10. Culinary Occupations. Instructional Materials Committee Recommendations Report.

    Science.gov (United States)

    Louisiana State Technical Resource Center, Natchitoches.

    This resource listing contains those culinary occupations instructional materials given a rating of "highly recommended" or "recommended" by a committee of instructors. Titles are arranged alphabetically by title within each of the following Classification of Instructional Programs (CIP) categories: institutional management;…

  11. DEVELOPMENT OF A GENERIC RECOMMENDER SYSTEM

    Directory of Open Access Journals (Sweden)

    Dan Munteanu

    2004-12-01

    Full Text Available his paper presents a recommender system for textual documents taken from web (given as bookmarks. The system uses for classification a combination of content, event and collaborative filters and for recommendation a modified Pearson-r algorithm. It uses implicit and explicit feedback for evaluating documents.

  12. Electrochemical biosensors: recommended definitions and classification

    OpenAIRE

    Thevenot, Daniel,; Toth, Klara; Durst, Richard; Wilson, George

    2001-01-01

    International audience; Two Divisions of the International Union of Pure and Applied Chemistry (IUPAC), namely Physical Chemistry (Commission I.7 on Biophysical Chemistry formerly Steering Committee on Biophysical Chemistry) and Analytical Chemistry (Commission V.5 on Electroanalytical Chemistry) have prepared recommendations on the definition, classification and nomenclature related to electrochemical biosensors; these recommendations could, in the future, be extended to other types of biose...

  13. The seniorgezond recommender: exploration put into practice

    NARCIS (Netherlands)

    Hollink, V.; Someren, M. van; Hagen, S. ten; Hilgersom, M.J.C.; Rovekamp, T.J.M.

    2007-01-01

    Recommender systems suggest objects to users navigating a web site. They observe the pages that a user visits and predict which other pages may be of interest. On the basis of these predictions recommenders select a number of pages that are suggested to the user. By far the most popular recommendati

  14. Fusing Recommendations for Social Bookmarking Websites

    DEFF Research Database (Denmark)

    Bogers, Toine; van den Bosch, Antal

    2011-01-01

    preferences. Most previous work in recommendation for social bookmarking suffers from a lack of comparisons between the different available approaches. In this article, we address this issue by comparing and evaluating eight recommendation approaches on four data sets from two domains. We find that approaches...

  15. Semantic Grounding Strategies for Tagbased Recommender Systems

    CERN Document Server

    Durao, Frederico

    2011-01-01

    Recommender systems usually operate on similarities between recommended items or users. Tag based recommender systems utilize similarities on tags. The tags are however mostly free user entered phrases. Therefore, similarities computed without their semantic groundings might lead to less relevant recommendations. In this paper, we study a semantic grounding used for tag similarity calculus. We show a comprehensive analysis of semantic grounding given by 20 ontologies from different domains. The study besides other things reveals that currently available OWL ontologies are very narrow and the percentage of the similarity expansions is rather small. WordNet scores slightly better as it is broader but not much as it does not support several semantic relationships. Furthermore, the study reveals that even with such number of expansions, the recommendations change considerably.

  16. A Personalized Word of Mouth Recommender Model

    Directory of Open Access Journals (Sweden)

    Chihli Hung

    2008-09-01

    Full Text Available Word of mouth (WOM has a powerful effect on consumer behavior. Manually collecting WOM is very time-consuming in the era of the Internet. An automatic WOM recommender model is useful for both marketers and consumers. There are many different product features and thus many consumer choices. Each individual consumer has different preferences and these preferences may be changed deliberately or unwittingly. However, most existing WOM recommender models do not adapt to user preferences. This study proposes a conceptual WOM recommender model, which contains WOM collecting, document processing, recommending and user preference processing phases. More specifically, the self-organizing map (SOM is used to store and abstract user preferences. This proposed WOM model makes recommendations to consumers or users according to their adaptive preferences.

  17. Recommendation-Aware Smartphone Sensing System

    Directory of Open Access Journals (Sweden)

    Mu-Yen Chen

    2014-12-01

    Full Text Available The context-aware concept is to reduce the gap between users and information systems so that the information systems actively get to understand users’ context and demand and in return provide users with better experience. This study integrates the concept of context-aware with association algorithms to establish the context-aware recommendation systems (CARS. The CARS contains three modules and provides the product recommendations for users with their smartphone. First, the simple RSSI Indoor localization module (SRILM locates the user position and detects the context information surrounding around users. Second, the Apriori recommendation module (ARM provides effective recommended product information for users through association rules mining. The appropriate product information can be received effectiveness and greatly enhanced the recommendation service.

  18. Diagnose nutricional para nitrogênio e potássio em bananeira por meio do sistema integrado de diagnose e recomendação (DRIS e de níveis críticos The N and K diagnosis on banana plants using the diagnosis and recommendation integrated system (DRIS and critical value approach

    Directory of Open Access Journals (Sweden)

    LUIZ ANTONIO JUNQUEIRA TEIXEIRA

    2002-08-01

    Full Text Available A partir de resultados de um experimento de campo com arranjo fatorial, no qual foi estudada a resposta à aplicação de N e K em bananeira, em dois ciclos de cultivo, avaliou-se o desempenho do diagnóstico nutricional para esses nutrientes, empregando-se o sistema integrado de diagnose e recomendação (DRIS e o critério de níveis críticos (NC. As situações nas quais se diagnosticou deficiência, foram classificadas como positivas (+, aquelas cujo diagnóstico indicou suficiência, como negativas (-. Em função da resposta na produção de frutos à aplicação de N ou K, classificaram-se os diagnósticos como verdadeiros (V ou falsos (F, resultando nas quatro possibilidades V+, V-, F+ e F-. Em relação ao N, a eficiência (%V+ e %V- dos diagnósticos baseados em NC foi de 48%; com o DRIS, foi de 69%. Para K, a eficiência dos diagnósticos feitos a partir do DRIS e NC foi de 63%. A proporção de diagnósticos de deficiência que se confirmaram com respostas positivas à aplicação de N em relação aos falsos positivos (%V+¸%F+, foi de 1,50 para o DRIS e de 0,68 para NC. Para os diagnósticos de deficiência de K, essa proporção foi de 1,67 para DRIS e NC. A variação líquida no rendimento (48 casos decorrente da aplicação de N associada a diagnósticos corretos foi de 124 t ha¹ para o DRIS e de 20 t ha¹ para NC. Para K, essa variação foi de 70 t ha¹ para o DRIS e NC.The Performance of DRIS and critical value approach (CVA diagnostics were evaluated based on leaf analysis from a field experiment on a factorial design to study the yield response of banana to N and K applications during two crop seasons. The situations identified as deficient were classified as positives (+ and those diagnosed as sufficient, were classified as negatives (-. According to the response on yield due the application of N or K, the diagnostics were classified as true (V or false (F. Four combinations were possible: V+, V-, F+ and F-. The

  19. A Novel Mobile Personalized Recommended Method Based on Money Flow Model for Stock Exchange

    Directory of Open Access Journals (Sweden)

    Qingzhen Xu

    2014-01-01

    Full Text Available Personalized recommended method is widely used to recommend commodities for target customers in e-commerce sector. The core idea of merchandise personalized recommendation can be applied to financial field, which can also achieve stock personalized recommendation. This paper proposes a new recommended method using collaborative filtering based on user fuzzy clustering and predicts the trend of those stocks based on money flow. We use M/G/1 queue system with multiple vacations and server close-down time to measure practical money flow. Based on the indicated results of money flow, we can select the more valued stock to recommend to investors. The experimental results show that the proposed method provides investors with reliable practical investment guidance and receiving more returns.

  20. Factors associated with knowledge of personal gestational weight gain recommendations.

    Science.gov (United States)

    Ledoux, Tracey; Van Den Berg, Patricia; Leung, Patrick; Berens, Pamela D

    2015-08-13

    Excess adiposity (obesity and excess gestational weight gain, GWG) during pregnancy (EADP) increases risk for gestational diabetes, preeclampsia, and child and maternal obesity. Personal GWG goals predict total GWG. Some estimates suggest only 30% of pregnant women have personal GWG goals that are congruent with Institute of Medicine GWG recommendations. The primary purpose of this study was to determine the extent to which perceived pre-pregnancy weight status, healthcare provider advice, knowledge of EADP risks, and value for healthy GWG predicted knowledge of GWG recommendations. The secondary purpose was to determine sources of GWG information among pregnant women. Pregnant women with a confirmed singleton pregnancy completed a one-time survey in obstetric clinic waiting rooms. Logistic regression analysis was used. 246 predominantly African American, low income, overweight/obese women completed surveys. Average age was 25 (SD 5.3) and gestation age ranged from 7 to 40 weeks. Knowledge of pre-pregnancy weight status was the only unique predictor of GWG recommendation knowledge (B = .642, p = .03). The top three sources of GWG information were physicians, internet, and books. The least frequently reported sources of GWG information were other healthcare providers, community programs, and television. In low income diverse overweight/obese pregnant women, accurate pre-pregnancy weight status perception was the only significant unique predictor of knowledge of GWG recommendations. Physicians were the preferred source of GWG information. Clinicians should have frequent, ongoing conversations about weight status with women before, during, and after pregnancy.

  1. When are Analyst Recommendation Changes Influential?

    OpenAIRE

    Roger K. Loh; Stulz, René M.

    2009-01-01

    Not all stock recommendation changes are equal. In a sample constructed to minimize the impact of confounding news, relatively few analyst recommendation changes are influential in the sense that they impact investors' beliefs about a firm in a way that could be noticed in that firm's stock returns. More than one-third of the stock-price reactions to analyst recommendation changes have the wrong sign and only approximately 10% have significant stock-price reactions at the 5% level using an ex...

  2. Leveraging position bias to improve peer recommendation.

    Directory of Open Access Journals (Sweden)

    Kristina Lerman

    Full Text Available With the advent of social media and peer production, the amount of new online content has grown dramatically. To identify interesting items in the vast stream of new content, providers must rely on peer recommendation to aggregate opinions of their many users. Due to human cognitive biases, the presentation order strongly affects how people allocate attention to the available content. Moreover, we can manipulate attention through the presentation order of items to change the way peer recommendation works. We experimentally evaluate this effect using Amazon Mechanical Turk. We find that different policies for ordering content can steer user attention so as to improve the outcomes of peer recommendation.

  3. Effective Personalized Recommendation in Collaborative Tagging Systems

    CERN Document Server

    Zhang, Zi-Ke

    2009-01-01

    Recently, collaborative tagging systems have attracted more and more attention and have been widely applied in web systems. Tags provide highly abstracted information about personal preferences and item content, and are therefore potential to help in improving better personalized recommendations. In this paper, we propose a tag-based recommendation algorithm considering the personal vocabulary and evaluate it in a real-world dataset: Del.icio.us. Experimental results demonstrate that the usage of tag information can significantly improve the accuracy of personalized recommendations.

  4. Mobile Recommendation Based on Link Community Detection

    Directory of Open Access Journals (Sweden)

    Kun Deng

    2014-01-01

    Full Text Available Since traditional mobile recommendation systems have difficulty in acquiring complete and accurate user information in mobile networks, the accuracy of recommendation is not high. In order to solve this problem, this paper proposes a novel mobile recommendation algorithm based on link community detection (MRLD. MRLD executes link label diffusion algorithm and maximal extended modularity (EQ of greedy search to obtain the link community structure, and overlapping nodes belonging analysis (ONBA is adopted to adjust the overlapping nodes in order to get the more accurate community structure. MRLD is tested on both synthetic and real-world networks, and the experimental results show that our approach is valid and feasible.

  5. Traffic management system: Recommendations. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-30

    This report identifies the primary and secondary air traffic networks inside and outside Buenos Aires Metropolitan Area where particular safety and traffic problems exist. The Consortium Louis Berger International, Inc.-IBI Group-UBATEC provides recommendations divided into two groups: one based on engineering aspects for each identified deficiency in the selected routes; and a second group that is based on the results of the evaluations of needs. This is Volume 5, Recommendations Final Report, and it provides recommendations to optimize transportation in the city of Buenos Aires.

  6. Generating Private Recommendations Efficiently Using Homomorphic Encryption and Data Packing

    DEFF Research Database (Denmark)

    Erkin, Zekeriya; Veugen, Thijs; Toft, Tomas

    2012-01-01

    security only against malicious third parties, but not the service provider. This creates a serious privacy risk for the users. In this paper, we aim to protect the private data against the service provider while preserving the functionality of the system. We propose encrypting private data and processing...... them under encryption to generate recommendations. By introducing a semitrusted third party and using data packing, we construct a highly efficient system that does not require the active participation of the user. We also present a comparison protocol, which is the first one to the best of our...... knowledge, that compares multiple values that are packed in one encryption. Conducted experiments show that this work opens a door to generate private recommendations in a privacy-preserving manner...

  7. Gender bias found in recommendation letters

    Science.gov (United States)

    Kruesi, Liz

    2016-11-01

    Female postdoctoral fellowship applicants are half as likely as their male counterparts to receive glowing recommendation letters, according to a study by researchers at Columbia University's Lamont-Doherty Earth Observatory (LDEO).

  8. EURRECA—Framework for Aligning Micronutrient Recommendations

    NARCIS (Netherlands)

    Veer, van 't P.; Grammatikaki, E.; Matthys, C.; Raats, M.M.; Contor, L.

    2013-01-01

    There is currently no standard approach for deriving micronutrient recommendations, and large variations exist across Europe, causing confusion among consumers, food producers, and policy makers. More aligned information could influence dietary behaviors and potentially lead to a healthier populatio

  9. 2016 Updated MASCC/ESMO Consensus Recommendations

    DEFF Research Database (Denmark)

    Herrstedt, Jørn; Roila, Fausto; Warr, David

    2017-01-01

    PURPOSE: This review summarizes the recommendations for the prophylaxis of nausea and vomiting in adults receiving highly emetogenic chemotherapy (HEC) which includes cisplatin, mechlorethamine, streptozocin, cyclophosphamide >1500 mg/m(2), carmustine, dacarbazine, and the combination of an anthr...

  10. Consistence beats causality in recommender systems

    CERN Document Server

    Zhu, Xuzhen; Hu, Zheng; Zhang, Ping; Zhou, Tao

    2015-01-01

    The explosive growth of information challenges people's capability in finding out items fitting to their own interests. Recommender systems provide an efficient solution by automatically push possibly relevant items to users according to their past preferences. Recommendation algorithms usually embody the causality from what having been collected to what should be recommended. In this article, we argue that in many cases, a user's interests are stable, and thus the previous and future preferences are highly consistent. The temporal order of collections then does not necessarily imply a causality relationship. We further propose a consistence-based algorithm that outperforms the state-of-the-art recommendation algorithms in disparate real data sets, including \\textit{Netflix}, \\textit{MovieLens}, \\textit{Amazon} and \\textit{Rate Your Music}.

  11. Personalized recommendation based on unbiased consistence

    Science.gov (United States)

    Zhu, Xuzhen; Tian, Hui; Zhang, Ping; Hu, Zheng; Zhou, Tao

    2015-08-01

    Recently, in physical dynamics, mass-diffusion-based recommendation algorithms on bipartite network provide an efficient solution by automatically pushing possible relevant items to users according to their past preferences. However, traditional mass-diffusion-based algorithms just focus on unidirectional mass diffusion from objects having been collected to those which should be recommended, resulting in a biased causal similarity estimation and not-so-good performance. In this letter, we argue that in many cases, a user's interests are stable, and thus bidirectional mass diffusion abilities, no matter originated from objects having been collected or from those which should be recommended, should be consistently powerful, showing unbiased consistence. We further propose a consistence-based mass diffusion algorithm via bidirectional diffusion against biased causality, outperforming the state-of-the-art recommendation algorithms in disparate real data sets, including Netflix, MovieLens, Amazon and Rate Your Music.

  12. Management Recommendations: Native Adaptive Management Program (NPAM)

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Management recommendations are a product of the decision support tool for the Native Adaptive Management Program (NPAM). The provides tall and mixed grass management...

  13. Machine learning paradigms applications in recommender systems

    CERN Document Server

    Lampropoulos, Aristomenis S

    2015-01-01

    This timely book presents Applications in Recommender Systems which are making recommendations using machine learning algorithms trained via examples of content the user likes or dislikes. Recommender systems built on the assumption of availability of both positive and negative examples do not perform well when negative examples are rare. It is exactly this problem that the authors address in the monograph at hand. Specifically, the books approach is based on one-class classification methodologies that have been appearing in recent machine learning research. The blending of recommender systems and one-class classification provides a new very fertile field for research, innovation and development with potential applications in “big data” as well as “sparse data” problems. The book will be useful to researchers, practitioners and graduate students dealing with problems of extensive and complex data. It is intended for both the expert/researcher in the fields of Pattern Recognition, Machine Learning and ...

  14. Preventive Care Recommendations for Adults with MS

    Science.gov (United States)

    ... often per physician recommend ation. Over age 40 Cardiovascular Disease Men over age 45 and women over age ... older should consume 1200-1500 mg daily. n Vitamin D. Many American adults are at risk of ...

  15. Final wilderness recommendation : Mattamuskeet National Wildlife Refuge

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This document is a letter to the legislative counsel containing a final recommendation of wilderness designation for part of the Mattamuskeet National Wildlife Refuge.

  16. Personalized Academic Research Paper Recommendation System

    OpenAIRE

    Lee, Joonseok; Lee, Kisung; Kim, Jennifer G.

    2013-01-01

    A huge number of academic papers are coming out from a lot of conferences and journals these days. In these circumstances, most researchers rely on key-based search or browsing through proceedings of top conferences and journals to find their related work. To ease this difficulty, we propose a Personalized Academic Research Paper Recommendation System, which recommends related articles, for each researcher, that may be interesting to her/him. In this paper, we first introduce our web crawler ...

  17. A Flexible Recommendation System for Cable TV

    OpenAIRE

    Goncalves, Diogo; Costa, Miguel; Couto, Francisco M.

    2016-01-01

    Recommendation systems are being explored by Cable TV operators to improve user satisfaction with services, such as Live TV and Video on Demand (VOD) services. More recently, Catch-up TV has been introduced, allowing users to watch recent broadcast content whenever they want to. These services give users a large set of options from which they can choose from, creating an information overflow problem. Thus, recommendation systems arise as essential tools to solve this problem by helping users ...

  18. WWW COLLABORATIVE RECOMMENDATION BASED ON RELIABILITY

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Collaborative filtering recommender systems often suffer from the "Matchmaker" problem, which comes from the false assumption that users are counted only based on their similarity, and high similarity means good advisers. In order to find good advisers for every user, a matchmaker's reliability mode based on the algorithm deriving from Hits is constructed, and it is applied in the proposed World Wide Web (WWW)collaborative recommendation system. Comparative experimental results also show that our approach obviously improves the substantial performance.

  19. Concept-based Recommendations for Internet Advertisement

    CERN Document Server

    Ignatov, Dmitry I

    2009-01-01

    The problem of detecting terms that can be interesting to the advertiser is considered. If a company has already bought some advertising terms which describe certain services, it is reasonable to find out the terms bought by competing companies. A part of them can be recommended as future advertising terms to the company. The goal of this work is to propose better interpretable recommendations based on FCA and association rules.

  20. RECOMMENDATION SYSTEM USING BLOOM FILTER IN MAPREDUCE

    Directory of Open Access Journals (Sweden)

    Reena Pagare

    2013-11-01

    Full Text Available Many clients like to use the Web to discover product details in the form of online reviews. The reviews are provided by other clients and specialists. Recommender systems provide an important response to the information overload problem as it presents users more practical and personalized information facilities. Collaborative filtering methods are vital component in recommender systems as they generate high-quality recommendations by influencing the likings of society of similar users. The collaborative filtering method has assumption that people having same tastes choose the same items. The conventional collaborative filtering system has drawbacks as sparse data problem & lack of scalability. A new recommender system is required to deal with the sparse data problem & produce high quality recommendations in large scale mobile environment. MapReduce is a programming model which is widely used for large-scale data analysis. The described algorithm of recommendation mechanism for mobile commerce is user based collaborative filtering using MapReduce which reduces scalability problem in conventional CF system. One of the essential operations for the data analysis is join operation. But MapReduce is not very competent to execute the join operation as it always uses all records in the datasets where only small fraction of datasets are applicable for the join operation. This problem can be reduced by applying bloomjoin algorithm. The bloom filters are constructed and used to filter out redundant intermediate records. The proposed algorithm using bloom filter will reduce the number of intermediate results and will improve the join performance.

  1. Recent developments in affective recommender systems

    Science.gov (United States)

    Katarya, Rahul; Verma, Om Prakash

    2016-11-01

    Recommender systems (RSs) are playing a significant role since 1990s as they provide relevant, personalized information to the users over the internet. Lots of work have been done in information filtering, utilization, and application related to RS. However, an important area recently draws our attention which is affective recommender system. Affective recommender system (ARS) is latest trending area of research, as publication in this domain are few and recently published. ARS is associated with human behaviour, human factors, mood, senses, emotions, facial expressions, body gesture and physiological with human-computer interaction (HCI). Due to this assortment and various interests, more explanation is required, as it is in premature phase and growing as compared to other fields. So we have done literature review (LR) in the affective recommender systems by doing classification, incorporate reputed articles published from the year 2003 to February 2016. We include articles which highlight, analyse, and perform a study on affective recommender systems. This article categorizes, synthesizes, and discusses the research and development in ARS. We have classified and managed ARS papers according to different perspectives: research gaps, nature, algorithm or method adopted, datasets, the platform on executed, types of information and evaluation techniques applied. The researchers and professionals will positively support this survey article for understanding the current position, research in affective recommender systems and will guide future trends, opportunity and research focus in ARS.

  2. Content recommendation, a challenge for television

    Directory of Open Access Journals (Sweden)

    Joëlle Farchy

    2016-07-01

    Full Text Available In this article, we use the term recommendation in order to analyze every apparatus aimed at guiding the Internet user toward a specific content, surrounded by an overabundant and profuse offer. For the purpose of the analysis, we distinguish four types of recommendation: on the one hand, editorial and contributive recommendation, based either on experts or users’ judgments and opinions, and on the other hand, aggregative and personalized. The latter appear to be more and more central, based on users’ online behaviour. With the algorithmic recommendation, alleged, declared or observed users’ preferences form the material of predictive recommendation in apparatuses developed by different operators of legacy media. This step is the almost final one in a process of delinearization and individualization. However, despite its efficiency, this form of recommendation raises a number of questions. More than the risk of confinement and filter bubble, the biggest problem seems to be related to the oligopolistic power of a few players, controlling consumer behaviour data.

  3. Recommendations for reducing ambiguity in written procedures.

    Energy Technology Data Exchange (ETDEWEB)

    Matzen, Laura E.

    2009-11-01

    Previous studies in the nuclear weapons complex have shown that ambiguous work instructions (WIs) and operating procedures (OPs) can lead to human error, which is a major cause for concern. This report outlines some of the sources of ambiguity in written English and describes three recommendations for reducing ambiguity in WIs and OPs. The recommendations are based on commonly used research techniques in the fields of linguistics and cognitive psychology. The first recommendation is to gather empirical data that can be used to improve the recommended word lists that are provided to technical writers. The second recommendation is to have a review in which new WIs and OPs and checked for ambiguities and clarity. The third recommendation is to use self-paced reading time studies to identify any remaining ambiguities before the new WIs and OPs are put into use. If these three steps are followed for new WIs and OPs, the likelihood of human errors related to ambiguity could be greatly reduced.

  4. Tier 3 Toxicity Value White Paper

    Science.gov (United States)

    The purpose of this white paper is to articulate the issues pertaining to Tier 3 toxicity values and provide recommendations on processes that will improve the transparency and consistency of identifying, evaluating, selecting, and documenting Tier 3 toxicity values for use in the Superfund and Resource Conservation and Recovery Act (RCRA) programs. This white paper will be used to assist regional risk assessors in selecting Tier 3 toxicity values as well as provide the foundation for future regional and national efforts to improve guidance and policy on Tier 3 toxicity values.

  5. On the Eff ects of Exploring Historical Commit Messages for Develop er Recommendation

    Institute of Scientific and Technical Information of China (English)

    YANG Hui; SUN Xiaobing; DUAN Yucong; LI Bin

    2016-01-01

    Many developer recommendation tech-niques have been developed in the literature. Among exist-ing studies, most of them are performed based on exploring the historical commit repository. The thought behind them is that developers who submit similar historical commits relevant to the incoming issue are more probably to be the candidates for the current issue resolution. But whether such a thought is always useful for developer recommen-dation? This paper aims at this problem by conducting a set of empirical studies on four real open-source projects. The results show that, 1) historical commit messages do well reflect the historical experience of the maintenance task of developers and can be used for developer recom-mendation in most of the time; 2) the number of historical commits submitted by the recommended developer(s) and the similarity value used to select the relevant historical commits should be carefully considered to recommend de-velopers for issue resolution; 3) The efficiency of issue res-olution process can be improved if some associated source code files relevant to this issue can be also recommended;and 4) developer recommendation techniques that rank the recommended developers based on the times of co-changed source code files cannot always produce correct recommen-dation results.

  6. Application of bioassay technique to determine onduty herbicide resistance in soil

    Science.gov (United States)

    Bakar, F. A. A.; Ismail, B. S.; Bajrai, F. S. M.

    2016-11-01

    A study was conducted to determine the resistance of OnDuty herbicide in paddy soil with different concentrations by using a broadleaf plant, Brassica juncea. The herbicide was used in the Clearfield® Production System that was adopted in Malaysia to overcome problems mainly caused by weedy rice. Evaluation of herbicide half-life was based on bioassay technique with different concentrations, i.e 0% (control), 50% (half dose), 100% (recommended dose) and 200% (double dose). The study was done in three replicates and followed the Complete Randomized Block Design (CRBD). Results showed that there was a correlation between the amount of herbicide doses and degradation period. The highest half-life value was shown by root inhibition in the double dose concentration of 33 days half-life, followed by the recommended dose with 23 days half-life. Meanwhile, the half dose treatment indicated a half-life value of 17 days for root and 11 days for shoot. Therefore, application of herbicides should follow the recommended dose as the degradation period will not be too long, hence providing maximum effectiveness of the herbicide to overcome weed infestation problems.

  7. Customer value in a credence service context

    NARCIS (Netherlands)

    Josje Dikkers; Dr. Gerrita van der Veen; Esther Verboon

    2014-01-01

    accepted abstract Quis14 conference Field findings show that value dimensions in legal services are functional, social and emotional. The last category emerges not only within but also outside the interaction with the lawyer. Recommendation of others or the trackrecord of lawyers for example, which

  8. Projects as value constellations

    DEFF Research Database (Denmark)

    Laursen, Markus

    Creating value has been outlined as very central to projects applying the organizational perspective to projects. It has been suggested that value is created in value constellations or project networks, where actors work together to create value. However, research on the value creation process...... in value constellations is scarce, and through an exploratory study of two project networks in a cultural setting we investigate how value is created in value constellations. We outline how each project may be a distinct type of value constellation, one project creates value for the partners of the network...... as a consortium, and the project creates value primarily for others as a facilitator....

  9. Recommending blood glucose monitors, a pharmacy perspective.

    Science.gov (United States)

    Carter, Alan

    2007-03-01

    Selection of what blood glucose monitoring system to utilize has become an issue for physicians, diabetes educators, pharmacists, and patients. The field of competing makes and models of blood glucose monitoring systems has become crowded, with manufacturers touting improvements in accuracy, ease of use/alternate site options, stored results capacity, software evaluation tools, and/or price point. Personal interviews of 12 pharmacists from community and academic practice settings about monitor preference, as well as results from a national survey of pharmacist recommendations, were compared to actual wholesale sales data to estimate the impact of such recommendations on final monitor selection by the patient. Accu-Chek monitors were recommended 34.65% of the time and represented 28.58% of sales, with a success rate of 82.48% of being the monitor selected. OneTouch monitors had 27.72% of recommendations but represented 31.43% of sales, indicating possible patient brand loyalty or formulary preference for that product. FreeStyle(R) monitors came in third for pharmacist recommendations and were selected by the patient 61.68% of the time when recommended. The category of "other monitor" choices was selected 60.89% of the time by patients given those suggestions. Included in the "other monitor" category was the new disposable monitor marketed as the Sidekick. Based on sales data provided, the Sidekick made up 2.87% of "other monitor" category sales, representing 68% of the "other monitor" segment. While patients frequently follow pharmacist monitoring system suggestions, the ultimate deciding factor is most often the final out-of-pocket cost to the patient. As a result, cost of supplies often becomes the most important determining factor in final monitor selection at the patient level. If the patient cannot afford to perform the recommended daily testing intervals, all other determining factors and suggestions become moot.

  10. Evidence-informed recommendations for rehabilitation with older adults living with HIV: a knowledge synthesis

    Science.gov (United States)

    O'Brien, Kelly K; Solomon, Patricia; Trentham, Barry; MacLachlan, Duncan; MacDermid, Joy; Tynan, Anne-Marie; Baxter, Larry; Casey, Alan; Chegwidden, William; Robinson, Greg; Tran, Todd; Wu, Janet; Zack, Elisse

    2014-01-01

    Objective Our aim was to develop evidence-informed recommendations for rehabilitation with older adults living with HIV. Design We conducted a knowledge synthesis, combining research evidence specific to HIV, rehabilitation and ageing, with evidence on rehabilitation interventions for common comorbidities experienced by older adults with HIV. Methods We included highly relevant HIV-specific research addressing rehabilitation and ageing (stream A) and high-quality evidence on the effectiveness of rehabilitation interventions for common comorbidities experienced by older adults ageing with HIV (stream B). We extracted and synthesised relevant data from the evidence to draft evidence-informed recommendations for rehabilitation. Draft recommendations were refined based on people living with HIV (PLHIV) and clinician experience, values and preferences, reviewed by an interprofessional team for Grading of Recommendations Assessment, Development, and Evaluation (GRADE) (quality) rating and revision and then circulated to PLHIV and clinicians for external endorsement and final refinement. We then devised overarching recommendations to broadly guide rehabilitation with older adults living with HIV. Results This synthesis yielded 8 overarching and 52 specific recommendations. Thirty-six specific recommendations were derived from 108 moderate-level or high-level research articles (meta-analyses and systematic reviews) that described the effectiveness of rehabilitation interventions for comorbidities that may be experienced by older adults with HIV. Recommendations addressed rehabilitation interventions across eight health conditions: bone and joint disorders, cancer, stroke, cardiovascular disease, mental health challenges, cognitive impairments, chronic obstructive pulmonary disease and diabetes. Sixteen specific recommendations were derived from 42 research articles specific to rehabilitation with older adults with HIV. The quality of evidence from which these

  11. The Value of Reciprocity

    Science.gov (United States)

    Molm, Linda D.; Schaefer, David R.; Collett, Jessica L.

    2007-01-01

    The value of reciprocity in social exchange potentially comprises both instrumental value (the value of the actual benefits received from exchange) and communicative or symbolic value (the expressive and uncertainty reduction value conveyed by features of the act of reciprocity itself). While all forms of exchange provide instrumental value, we…

  12. Recommendations on Model Fidelity for Wind Turbine Gearbox Simulations: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Y.; Keller, J.; La Cava, W.; Austin, J.; Nejad, A. R.; Halse, C.; Bastard, L.; Helsen, J.

    2015-01-01

    This work investigates the minimum level of fidelity required to accurately simulate wind turbine gearboxes using state-of-the-art design tools. Excessive model fidelity including drivetrain complexity, gearbox complexity, excitation sources, and imperfections, significantly increases computational time, but may not provide a commensurate increase in the value of the results. Essential design parameters are evaluated, including the planetary load-sharing factor, gear tooth load distribution, and sun orbit motion. Based on the sensitivity study results, recommendations for the minimum model fidelities are provided.

  13. Recommending randomized trials for pediatric leukemia: observer and physician report of recommendations.

    Science.gov (United States)

    Hazen, Rebecca; Greenley, Rachel Neff; Drotar, Dennis; Kodish, Eric

    2007-06-01

    Physicians' presentation of treatment options in a non-coercive manner is critical for informed consent for participation in randomized clinical trials (RCTs). This study examined discrepancies between observer and physician report of treatment recommendations for pediatric leukemia RCTs. This study also assessed relationships between recommendations and decisions to participate in RCTs. Participants were 104 parents of children with leukemia and the treating physicians. Measures included observations of informed consent conferences (ICCs), physician report of treatment recommendations, and parent report of trial participation. Observation revealed that physicians recommended RCTs in 38% of ICCs, while physicians reported recommending RCTs in 73% of ICCs. Treatment recommendations were unrelated to decisions to participate in RCTs. Results highlight the importance of enhancing parent-physician communication regarding RCT participation.

  14. Heterogeneity of Rabies Vaccination Recommendations across Asia

    Directory of Open Access Journals (Sweden)

    Philippe Buchy

    2017-07-01

    Full Text Available Asian countries bear the greatest burden of the disease, with a majority (59% of rabies-related deaths occurring in Asia. In order to promote best practices, we summarized national human vaccination guidelines across this region, to highlight differences and similarities and to discuss the aspects that would benefit from updates. National management guidelines for rabies were retrieved from various sources to extract information on rabies pre- and post-exposure prophylaxis (PrEP, and PEP, booster vaccination, and route of administration. Rabies guidelines recommendations for wound management and PrEP across Asia are broadly aligned to the World Health Organization (WHO guidelines. For PEP, the 5-dose Essen, and the 4-dose Zagreb are the regimens of choice for intramuscular (IM, and the Thai Red Cross regimen for intradermal (ID, administration. Several national guidelines have yet to endorse ID vaccine administration. Most guidelines recommend rabies immunoglobulin in category III exposures. Booster recommendations are not included in all guidelines, with limited clarity on booster requirement across the spectrum of risk of rabies exposure. In conclusion, national recommendations across Asian countries differ and while some guidelines are closely aligned to the WHO recommendations, resource-saving ID administration and use of rational abbreviated schedules have yet to be endorsed.

  15. Growing Wikipedia Across Languages via Recommendation

    Science.gov (United States)

    Wulczyn, Ellery; West, Robert; Zia, Leila; Leskovec, Jure

    2016-01-01

    The different Wikipedia language editions vary dramatically in how comprehensive they are. As a result, most language editions contain only a small fraction of the sum of information that exists across all Wikipedias. In this paper, we present an approach to filling gaps in article coverage across different Wikipedia editions. Our main contribution is an end-to-end system for recommending articles for creation that exist in one language but are missing in another. The system involves identifying missing articles, ranking the missing articles according to their importance, and recommending important missing articles to editors based on their interests. We empirically validate our models in a controlled experiment involving 12,000 French Wikipedia editors. We find that personalizing recommendations increases editor engagement by a factor of two. Moreover, recommending articles increases their chance of being created by a factor of 3.2. Finally, articles created as a result of our recommendations are of comparable quality to organically created articles. Overall, our system leads to more engaged editors and faster growth of Wikipedia with no effect on its quality.

  16. [The latest in paediatric resuscitation recommendations].

    Science.gov (United States)

    López-Herce, Jesús; Rodríguez, Antonio; Carrillo, Angel; de Lucas, Nieves; Calvo, Custodio; Civantos, Eva; Suárez, Eva; Pons, Sara; Manrique, Ignacio

    2017-04-01

    Cardiac arrest has a high mortality in children. To improve the performance of cardiopulmonary resuscitation, it is essential to disseminate the international recommendations and the training of health professionals and the general population in resuscitation. This article summarises the 2015 European Paediatric Cardiopulmonary Resuscitation recommendations, which are based on a review of the advances in cardiopulmonary resuscitation and consensus in the science and treatment by the International Council on Resuscitation. The Spanish Paediatric Cardiopulmonary Resuscitation recommendations, developed by the Spanish Group of Paediatric and Neonatal Resuscitation, are an adaptation of the European recommendations, and will be used for training health professionals and the general population in resuscitation. This article highlights the main changes from the previous 2010 recommendations on prevention of cardiac arrest, the diagnosis of cardiac arrest, basic life support, advanced life support and post-resuscitation care, as well as reviewing the algorithms of treatment of basic life support, obstruction of the airway and advanced life support. Copyright © 2016. Publicado por Elsevier España, S.L.U.

  17. CONSTRAINT INFORMATIVE RULES FOR GENETIC ALGORITHM-BASED WEB PAGE RECOMMENDATION SYSTEM

    Directory of Open Access Journals (Sweden)

    S. Prince Mary

    2013-01-01

    Full Text Available To predict the users navigation using web usage mining is the primary motto of the web page recommendation. Currently, researchers are trying to develop a web page recommendation using pattern mining technique. Here, we propose a technique for web page recommendation using genetic algorithm. It consists of three phases as data preparation, mining of informative rules and recommendation. The data preparation contains data preprocessing and user identification. The genetic algorithm is used to mine the informative rule. The genetic algorithm involves three processes which are calculating the fitness values, crossover and mutation. We use three different constraints as time duration, quality and recent visit to allow the process for next stage after the initial fitness calculation. We have to repeat these processes to find the best solution. To form the recommendation tree, we use the best solution which we obtain by means of genetic algorithm.

  18. The Study of Bogor Botanical Garden Ecotourism Value Chain

    OpenAIRE

    Doni Yusri; Arief Daryanto; Hadi K. Purwadaria

    2012-01-01

    The objective of this study were : 1) to improve development of Bogor Botanical Garden ecotourism value chain, 2) to recommend strategies of development for Bogor Botanical Garden ecotourism value chain, and 3) to formulate programs that increase value added for Bogor Botanical Garden value chain, especially for involved SME’s. Data collected from survey, in depth interview, and literature was analyzed using descriptive analysis, value chain analysis, SWOT analysis. The results of SWOT analys...

  19. Neural bases of recommendations differ according to social network structure.

    Science.gov (United States)

    O'Donnell, Matthew Brook; Bayer, Joseph B; Cascio, Christopher N; Falk, Emily B

    2017-01-01

    Ideas spread across social networks, but not everyone is equally positioned to be a successful recommender. Do individuals with more opportunities to connect otherwise unconnected others-high information brokers-use their brains differently than low information brokers when making recommendations? We test the hypothesis that those with more opportunities for information brokerage may use brain systems implicated in considering the thoughts, perspectives, and mental states of others (i.e. 'mentalizing') more when spreading ideas. We used social network analysis to quantify individuals' opportunities for information brokerage. This served as a predictor of activity within meta-analytically defined neural regions associated with mentalizing (dorsomedial prefrontal cortex, temporal parietal junction, medial prefrontal cortex, /posterior cingulate cortex, middle temporal gyrus) as participants received feedback about peer opinions of mobile game apps. Higher information brokers exhibited more activity in this mentalizing network when receiving divergent peer feedback and updating their recommendation. These data support the idea that those in different network positions may use their brains differently to perform social tasks. Different social network positions might provide more opportunities to engage specific psychological processes. Or those who tend to engage such processes more may place themselves in systematically different network positions. These data highlight the value of integrating levels of analysis, from brain networks to social networks. © The Author (2017). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  20. Location-aware News Recommendation System with Using Fuzzy Logic

    Directory of Open Access Journals (Sweden)

    Mehdi Nejati

    2016-10-01

    Full Text Available with release of a huge amount of news on the Internet and the trend of users to Web-based news services.it is necessary to have a recommendation system. To grab attentions to news, news services use a number of criteria that called news values and user location is an important factor for it. In this paper, LONEF is proposed as a tow stage recommendation system. In first stage news are ranked by user’s locations and in second stage news are recommended by location Preferences, recency, Trustworthiness, groups priorities and popularity. To reduce ambiguity these properties is used tow Mamdani fuzzy interference and case-based decision systems. In Mamdani fuzzy interference system, it is tried to increase the system speed by optimizing selection of rules and membership functions and because of ambiguous feedback implementation, a decision making system is used to enable better simulation of user’s activities. Performance of our proposed approach is demonstrated in the experiments on different news groups.