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Sample records for rechazo vascular agudo

  1. Anticuerpos anti-HLA y rechazo agudo del injerto renal en los niños

    OpenAIRE

    Galeas, Rubén Arturo; Gomezchico-Velasco, Rebeca; Valverde, Saúl; Ramón-García, Guillermo; Velásquez-Jones, Luis; Romero-Navarro, Benjamín; Hernández, Ana María; Vargas, Arindal; Leo, Claudia de; Medeiros, Mara

    2010-01-01

    Introducción. A pesar de que las nuevas terapias inmunosupresoras han mejorado notablemente la evolución clínica de los trasplantes renales, los rechazos agudo y crónico siguen limitando la sobrevida a largo plazo del injerto. En base a lo anterior, el objetivo de este estudio fue determinar la presencia de anticuerpos séricos contra antígenos de histocompatibilidad (HLA) clase I y clase II en niños con rechazo agudo del injerto renal. Métodos. Se realizó un estudio clínico prospectivo en pac...

  2. Dcumento Rechazo MetaBiblioteca

    OpenAIRE

    prueba1, prueba; Informe actividades realizadas sobre OJS UPTC

    2016-01-01

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  3. Vivendo o acidente vascular encefálico agudo: significados da doença para pessoas hospitalizadas

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    Samia Jardelle Costa de Freitas Maniva

    2013-04-01

    Full Text Available Objetivou-se compreender o significado da experiência vivenciada pela pessoa adoecida por acidente vascular encefálico agudo. Trata-se de estudo qualitativo, fundamentado nos pressupostos teóricos do interacionismo simbólico, realizado em uma unidade especializada no tratamento de acidente vascular encefálico de um hospital terciário, situado na cidade de Fortaleza, CE. Participaram do estudo 10 pacientes. A coleta de dados ocorreu por meio de entrevista aberta e os dados foram organizados e analisados segundo a técnica de enunciação. Cumpriram-se todos os aspectos éticos. O significado da experiência de adoecimento foi construído com base na percepção dos sentimentos surgidos durante a hospitalização, caracterizados por medo da morte e das sequelas da doença; tristeza pelo distanciamento do lar; alívio, ao evidenciar-se melhora do quadro clínico, e desejo de mudança dos hábitos de vida. Apreendeu-se que a experiência de adoecimento por acidente vascular encefálico é complexa, e nela os significados são elaborados com base em sentimentos, ações e comportamentos dos sujeitos.

  4. Vivendo o acidente vascular encefálico agudo: significados da doença para pessoas hospitalizadas

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    Samia Jardelle Costa de Freitas Maniva

    Full Text Available Objetivou-se compreender o significado da experiência vivenciada pela pessoa adoecida por acidente vascular encefálico agudo. Trata-se de estudo qualitativo, fundamentado nos pressupostos teóricos do interacionismo simbólico, realizado em uma unidade especializada no tratamento de acidente vascular encefálico de um hospital terciário, situado na cidade de Fortaleza, CE. Participaram do estudo 10 pacientes. A coleta de dados ocorreu por meio de entrevista aberta e os dados foram organizados e analisados segundo a técnica de enunciação. Cumpriram-se todos os aspectos éticos. O significado da experiência de adoecimento foi construído com base na percepção dos sentimentos surgidos durante a hospitalização, caracterizados por medo da morte e das sequelas da doença; tristeza pelo distanciamento do lar; alívio, ao evidenciar-se melhora do quadro clínico, e desejo de mudança dos hábitos de vida. Apreendeu-se que a experiência de adoecimento por acidente vascular encefálico é complexa, e nela os significados são elaborados com base em sentimentos, ações e comportamentos dos sujeitos.

  5. Uso de alteplase no tratamento do acidente vascular encefálico isquêmico agudo: o que sabem os enfermeiros?

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    Samia Jardelle Costa de Freitas Maniva

    2012-06-01

    Full Text Available O estudo objetivou analisar o conhecimento de enfermeiros acerca do uso de alteplase no tratamento do acidente vascular encefálico (AVE isquêmico agudo. Estudo descritivo-exploratório realizado em uma unidade de AVE de um hospital público localizado na cidade de Fortaleza-CE, durante o mês de outubro de 2010. Participaram do estudo dez enfermeiros, com idade média de 25 anos. Os benefícios da medicação foram apresentados em justaposição com as limitações do uso. Estratégias para ampliar a utilização de alteplase foram apontadas pelos enfermeiros. O conhecimento da realidade investigada contribui na construção do saber de enfermagem e pode auxiliar o enfermeiro que presta assistência direta ao paciente que se submete a este tratamento.

  6. Identificación de síntomas relacionados al Síndrome de Apnea Obstructiva del sueño en historias clínicas de pacientes con eventos vasculares agudos.

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    Darwin Roger VIZCARRA ESCOBAR

    2006-07-01

    Full Text Available El síndrome de apnea obstructiva del sueño (SAOS se caracteriza por ronquidos, pausas en la respiración y somnolencia diurna excesiva entre los síntomas más relevantes. Se ha demostrado una asociación con incremento de riesgo vascular en pacientes con SAOS. Objetivo: Evaluar si el personal médico busca síntomas relacionados al SAOS en pacientes con un cuadro cerebrovascular o síndrome coronario agudo, en los servicios de Medicina del Hospital Nacional Cayetano Heredia en Lima, Perú, desde septiembre del 2003 hasta septiembre del 2004. Materiales y métodos: Se planteó un estudio observacional retrospectivo. Se revisaron historias clínicas de 291 pacientes con diagnóstico al ingreso de accidente cerebrovascular, ataque isquémico transitorio o síndrome coronario agudo, buscando información sobre síntomas relacionados al SAOS, incluyendo evaluación por especialidades y epicrisis, detallando los evaluadores que recogieron los datos. Resultados: En la evaluación de 291 pacientes participaron 1122 evaluadores, 0,98 % de ellos consignó descartar el SAOS, que correspondió a 9 pacientes. En sólo 1 paciente se sugirió realizar un estudio de polisomnografía para corroborar el diagnóstico, sin ofrecerse ninguna opción terapéutica. Del total de pacientes, en el 6,87 % se indagó por ronquidos durante el sueño, 28,52 % por somnolencia y 0,68 % por episodios de apneas durante el sueño. Conclusiones: No se realiza una adecuada búsqueda del SAOS en pacientes con un evento cardiovascular o cerebrovascular agudo. En los pocos pacientes en los que se sospecha esta patología no existe seguimiento clínico ni tampoco se ofrece opción diagnóstica ni terapéutica alguna. (Rev Med Hered 2006;17:148-155.

  7. Vivendo o acidente vascular encefálico agudo: significados da doença para pessoas hospitalizadas Viviendo el accidente cerebrovascular agudo: significado de la enfermedad para personas hospitalizadas Experiencing acute stroke: the meaning of the illness for hospitalized patients

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    Samia Jardelle Costa de Freitas Maniva

    2013-04-01

    Full Text Available Objetivou-se compreender o significado da experiência vivenciada pela pessoa adoecida por acidente vascular encefálico agudo. Trata-se de estudo qualitativo, fundamentado nos pressupostos teóricos do interacionismo simbólico, realizado em uma unidade especializada no tratamento de acidente vascular encefálico de um hospital terciário, situado na cidade de Fortaleza, CE. Participaram do estudo 10 pacientes. A coleta de dados ocorreu por meio de entrevista aberta e os dados foram organizados e analisados segundo a técnica de enunciação. Cumpriram-se todos os aspectos éticos. O significado da experiência de adoecimento foi construído com base na percepção dos sentimentos surgidos durante a hospitalização, caracterizados por medo da morte e das sequelas da doença; tristeza pelo distanciamento do lar; alívio, ao evidenciar-se melhora do quadro clínico, e desejo de mudança dos hábitos de vida. Apreendeu-se que a experiência de adoecimento por acidente vascular encefálico é complexa, e nela os significados são elaborados com base em sentimentos, ações e comportamentos dos sujeitos.Se objetivó comprender el significado de la experiencia de la persona que padeció accidente cerebrovascular agudo. Estudio cualitativo, fundamentado en los presupuestos teóricos del interaccionismo simbólico, realizado en unidad especializada en tratamiento de accidente cerebrovascular de un hospital terciario en Fortaleza-CE. Participaron diez pacientes. Datos recolectados mediante entrevista abierta, organizados y analizados según técnica de enunciación. Se cumplió con todos los aspectos éticos. El significado de la experiencia del padecimiento fue construido en base a la percepción de los sentimientos surgidos durante la internación, caracterizados por el miedo a la muerte y a las secuelas de la enfermedad; tristeza por alejarse del hogar; alivio al evidenciarse mejoras del cuadro clínico; e intención de cambio de hábitos de vida

  8. Efeitos agudos dos estrogênios associados a progestogênios sobre a trigliceridemia e reatividade vascular pós-prandial Acute effects of the use of estrogens in association with progestogens on postprandial triglyceridemia and vascular reactivity

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    Silvio C.M. Santos

    2004-11-01

    Full Text Available OBJETIVO: Avaliar se a terapia de reposição hormonal com estrogênios e progestogênios, em mulheres hipertensas na pós-menopausa, modifica a trigliceridemia e a reatividade vascular pós-prandial. MÉTODOS: Estudo controlado, duplo cego, cruzado contra placebo em 15 mulheres na pós-menopausa (idade de 50 a 70, média = 61,6 ± 6 anos, sorteadas para 2 semanas de placebo ou ingestão oral de 0,625 mg de estrogênios conjugados eqüinos e 2,5 mg de medroxiprogesterona e alimentadas com refeição rica em gorduras (897 calorias; 50,1% de gorduras. Foi medida a reatividade vascular (RV - % de variação dos diâmetros do vaso entre o jejum e 2h após a alimentação, usando-se método ultra-sonográfico automatizado. Foram também determinados o perfil lipídico e a glicose, em jejum e 2h após a alimentação rica em gorduras. RESULTADOS: Com o placebo, a reatividade vascular (RV diminuiu de 3,20 ± 17% em jejum para -2,1 ± 30%, 2h após a alimentação (p = 0,041, e com terapia de reposição hormonal, a reatividade vascular diminuiu de 6,14 ± 27% em jejum para -0,05±18%, 2h após a alimentação (p=NS. A trigliceridemia pós-prandial aumentou, 35 ± 25% com o placebo, e 12 ± 10% com a terapia de reposição hormonal (P OBJECTIVE: To assess whether hormone replacement therapy with estrogens in association with progestogens in postmenopausal hypertensive women alters postprandial triglyceridemia and vascular reactivity. METHODS: A double-blind, placebo-controlled, crossover study was carried out with 15 postmenopausal women (age range: 50 to 70 years, mean = 61.6 ± 6 years randomly assigned to 2 weeks of placebo or oral ingestion of 0.625 mg of equine conjugated estrogens and 2.5 mg of medroxyprogesterone, fed a high-fat diet (897 calories; 50.1% fat. Vascular reactivity (VR - % of vessel diameter variation in the fasting period and 2 hours after meals was measured by using the automated ultrasound method. Lipid profile and glycemia

  9. Rechazo y retrasplante corneal Corneal rejection and re-transplantation

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    Miguel O Mokey Castellanos

    2007-06-01

    Full Text Available Se efectuó una investigación observacional análítica retrospectiva, sobre los transplantes corneales efectuados en el Servicio de Oftalmología del Hospital "Hermanos Ameijeiras. Rechazaron 76 pacientes, que se compararon con un control de 89 pacientes, que en un período similar no tuvieron rechazo. El queratocono fue la afección corneal que predominó. El primer lugar en los rechazos correspondió a queratoherpes (43,5 %. El menor índice de rechazo fue para el queratocono (8,8 %. Se analizó la multiplicidad de rechazos; y fue frecuente que se presentara un solo rechazo, aunque sí hubo congruencia entre el número de rechazos y la necesidad de retrasplantes. Se encontró que los resultados de la conducta médica o quirúrgica se relacionaban con la causa. Se calcula un índice de supervivencia (Kaplan-Meier, que concluye que en los primeros dos años existe menos posibilidad de aparición de rechazoAn retrospective observational analytical research was conducted on corneal transplants performed at Ophthalmological Service in “Hermanos Ameijeiras” hospital . Seventy six patients had graft rejection and were compared to a control group of 89 patients that did not present rejection in the same period of time. Keratoconus was the prevailing corneal problem. The highest rejection rate corresponded to keratoherpes (43,5% whereas the lowest rate was for keratoconus (8,8%. Multiplicity of rejections was analyzed and it was found that mostly one graft rejection occured, but number of rejections was associated with the need of re-transplantation. It was found that the results of medical or surgical performance were related to the cause of graft rejection. A survival index (Kaplan-Meier was estimated, which showed that occurence of graf rejection is less probable in the first two years

  10. Terapéutica del dolor agudo

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    Alonso Babarro, Alberto

    2006-01-01

    El abordaje del dolor agudo en la práctica clínica debe empezar siempre por una correcta valoración. La evaluación debe incluir tanto la investigación sobre el probable origen del dolor, sus características y su mecanismo fisiopatológico como la determinación de la intensidad del dolor para facilitarnos el control del tratamiento propuesto. Numerosos trabajos han evaluado mediante revisiones sistemáticas la utilidad de los diferentes tratamientos en los distintos cuadros de dolor agudo. A par...

  11. Nuevos antiagregantes plaquetarios en síndrome coronario agudo

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    Andrés F Buitrago

    2013-06-01

    Full Text Available En la actualidad las enfermedades cardiovasculares son la principal causa de muerte en los países industrializados y para 2020, lo serán en países en vía de desarrollo. El síndrome coronario agudo se caracteriza por la ruptura o erosión de una placa aterosclerótica que trae consigo grados variables de trombosis y embolización distal, que llevan a una disminución en la perfusión miocárdica. Posterior a la disrupción vascular, empieza un proceso de agregación, activación y adhesión plaquetaria que inicia la formación del trombo mural. Dado que el primer paso en la formación del trombo coronario involucra la activación y la agregación plaquetaria, el tratamiento con medicamentos antiplaquetarios es una de las piedras angulares del síndrome coronario agudo. La antiagregación dual con ácido acetil salicílico y un inhibidor del receptor P2Y12, hacen parte del manejo actual de los pacientes con síndrome coronario agudo y de aquellos sometidos a intervención coronaria percutánea. El clopidogrel es el inhibidor del receptor P2Y12 más utilizado; sin embargo, sus beneficios clínicos se ven limitados por varios factores que interfieren con la conversión del medicamento a su metabolito activo. Es por esto que recientemente se han desarrollado nuevos inhibidores del receptor P2Y12, como prasugrel y ticagrelor, con un efecto antiplaquetario más potente y mayores beneficios clínicos. Las actualizaciones recientes de las guías de manejo basadas en la evidencia los han incluido como parte del tratamiento de esta patología con un grado de recomendación incluso mayor que el de clopidogrel.

  12. Edema pulmonar agudo neurogênico: relato de caso

    OpenAIRE

    Brito,José Correia De Farias; Diniz,Maria Cerly Almeida; Rosas,Roberto Ramalho; Silva,José Alberto Gonçalves Da

    1995-01-01

    Os autores apresentam um caso de edema pulmonar agudo numa paciente de 28 anos de idade acometida de hemorragia subaracnóidea secundária à rotura de aneurisma intracraniano. A sintomatologia respiratória ocorreu durante o agravamento do quadro neurológico. Alguns aspectos etiológicos e fisiopatogênicos do edema pulmonar agudo neurogênico são analisados.

  13. Duelo, tristeza y rechazo del inconsciente // Mourning, sadness and rejection of the subconscious

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    David Vargas Castro

    2011-06-01

    Full Text Available En el presente texto se articulan desarrollos realizados por Freud y Lacan a propósito del duelo con el fin de responder a la relación entre éste y lo que Lacan propone en Televisión sobre la tristeza y el rechazo del inconsciente. Para tales fines, se parte de las preguntas e intentos de respuestas dadas por Freud en el plano de la economía libidinal a propósito del duelo, para pasar a los desarrollos de orden ético y moral que Lacan plantea a propósito de la tristeza. De esta forma, el rechazo del inconsciente presente en las psicosis se distingue del que tiene lugar en el duelo, al considerar la tristeza un afecto que dará cuenta del rechazo del deseo del Otro. // This text articulates developments made by Freud and Lacan about mourning to attempt a response on how this relates to Lacan‟s proposal in Television about sadness and rejection of the unconscious. To do this, the text departs from the questions and answers given by Freud in the field of the economy of the libido referring to mourning and then moves on to the ethical and moral aspects that Lacan refers about sadness. Consequently, from this perspective the rejection of the unconscious in the psychosis is different from the one that takes place in mourning, considering sadness as an affection that will evidence the rejection of the desire of the Other.

  14. Papel de la experiencia en la aceptación vs. rechazo del paciente con esquizofrenia

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    Carmen Senra-Rivera; Alessandra de Arriba-Rossetto; Gloria Seoane-Pesqueira

    2008-01-01

    En esta investigación se analiza la influencia que pueden tener distintos tipos y grados de experiencia con la enfermedad mental en la aceptación vs. rechazo del paciente con esquizofrenia. Participaron en el estudio 236 estudiantes universitarios que cumplimentaron una escala de distancia social relacionada con una viñeta en la que se describe un episodio psicótico de un paciente (hombre o mujer) con esquizofrenia y una escala que evalúa distintos tipos y grados de experiencia co...

  15. EL BANANO VERDE DE RECHAZO EN LA PRODUCCIÓN DE ALCOHOL CARBURANTE

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    Angélica María Afanador

    Full Text Available Se describe el estado del conocimiento sobre la producción de alcohol anhidro a partir de banano de rechazo mediante un análisis comparativo de los estudios sobre el aprovechamiento de esta fruta en el Urabá antioqueño desde la década de 1980 hasta la actualidad. Contempla su disponibilidad como materia prima, su composición química, los procesos fisicoquímicos de transformación del banano en alcohol anhidro y los impactos ambientales potenciales de esta industria. Si bien es enorme el volumen de banano de rechazo, existe incertidumbre sobre su disponibilidad para la industria del alcohol, ya que se emplea en la producción de abonos y la alimentación animal. No obstante los avances y posibilidades de perfeccionar el proceso tradicional de producción de alcohol anhidro (hidrólisis ácida o enzimática y fermentación alcohólica, la fermentación ABE se perfila como un proceso industrial en el futuro cercano, apoyado en tecnologías de deshidratación como la pervaporación y bioadsorción. A la fecha no se conocen estudios de impacto ambiental de la producción de etanol a base de banano verde.

  16. Actitudes ante los impuestos en Roma : aceptación, resignación y rechazo

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    Carlos Jordán Reyes

    2007-01-01

    Full Text Available Las actitudes de los contribuyentes romanos ante los impuestos no fue siempre la misma. Variaron en función de la naturaleza de cada tributo, de los procedimientos recaudatorios de cada momento y lugar y de las circunstancias personales del contribuyente. El tributo en cuanto tal no siempre generó rechazo. A veces fue asumido como una contrapartida lógica del derecho de ciudadanía y a veces incluso era autoimpuesto voluntariamente. A su vez, el rechazo a los tributos se manifestaba de muy diversos modos —la evasión fiscal, la búsqueda del privilegio, la protesta colectiva y el recurso ante la autoridad judicial— cada uno con una gran variedad de matices.The attitudes of Roman contributors towards taxes were not always the same. They differed depending on the nature of each tax, on the tax collection procedures, on the moment and place and the personal circunstances of tax contributors. Taxes as such were not always rejected. Sometimes they were seen as a logical counterpart of the right to citizenship and some other times they were voluntarily self-imposed. At the same time, the rejection of taxes was shown in many different ways: tax evasion, the search for privilege, collective protest, and the appeal to the judicial authorities; all of these including in turn a great variety of forms.

  17. Comunicación interventricular post infarto agudo del miocardio

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    Fabián A. Ruiz, MD

    2013-11-01

    En este artículo se expone el caso de un paciente con síndrome coronario agudo sin terapia de reperfusión inicial, con posterior ruptura del septum interventricular, en quien se evidenció la utilidad de la ecocardiografía en el diagnóstico de dicha entidad.

  18. Oxcarbazepina para los episodios afectivos agudos en el trastorno bipolar

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    Akshya Vasudev

    2012-09-01

    Se necesitan ensayos controlados con asignación aleatoria con adecuado poder estadístico y de buena calidad metodológica para informar el potencial terapéutico de la oxcarbazepina a través del espectro de episodios agudos en el trastorno bipolar.

  19. Influencia del rechazo escolar sobre la alta ansiedad ante el castigo escolar en educación primaria

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    María Isabel Gómez-Núñez

    2017-12-01

    Full Text Available El objetivo de este estudio consistió en analizar la capacidad predictiva del rechazo escolar sobre los altos niveles de ansiedad ante el castigo escolar (ACE. Para ello, se reclutó una muestra de 1,003 estudiantes de Educación Primaria con edades comprendidas entre los 8 y los 12 años. Los instrumentos empleados fueron el Inventario de Ansiedad Escolar para Educación Primaria (IAEP y el School Refusal Assessment Scale-Revised for Children (SRAS-R-C. Los resultados del análisis de regresión logística revelaron que el rechazo escolar para evitar estímulos que provocan emociones negativas actuaba como una variable predictora estadísticamente significativa de la ACE en la muestra total, en las muestras por sexo (chicos y chicas y en las muestras por curso académico (3.°, 4.°, 5.° y 6.° de Educación Primaria. Por otro lado, el rechazo escolar para evitar situaciones sociales aversivas y/o de evaluación y el rechazo escolar para llamar la atención influían positivamente sobre la alta ACE en la muestra de chicos y en 4.° de Educación Primaria, respectivamente. Estos resultados muestran la importancia de valorar el rechazo escolar, por la influencia que podría ejercer en la aparición de altos niveles de ansiedad ante el castigo escolar.

  20. Manejo prehospitalario del síndrome coronario agudo

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    Borrego Alfaraz, Cristina

    2017-01-01

    [EN] La cardiopatía isquémica, concretamente el síndrome coronario agudo, es una de las principales causas de mortalidad a nivel mundial. Además, con el envejecimiento de la población, su incidencia aumentará en las próximas décadas. Es por ello por lo que el conocimiento sobre este tema y la mejora en su abordaje se tornan imprescindibles. De esta manera, el manejo prehospitalario del síndrome coronario agudo se caracteriza por su rápida detección a través de la interpretación de un el...

  1. Vasculites e eosinófilos em biópsia endomiocárdica, como preditores de rejeição em transplante cardíaco Vasculitis y eosinófilos en biopsia endomiocárdica, como predictores de rechazo en transplante cardíaco Vasculitides and eosinophils in emdomyocardial biopsies as rejection predictors in heart transplantation

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    Reginaldo Cipullo

    2011-08-01

    Full Text Available FUNDAMENTO: O significado clínico de vasculites, lesões isquêmicas, efeito Quilty e da presença de eosinófilos em biópsias endomiocárdicas de receptores de transplante cardíaco com rejeições leves não foi ainda estabelecido. OBJETIVO: Verificar se esses achados histológicos encontrados nas biópsias endomiocárdicas (eosinófilos, vasculites, efeito Quilty e lesões isquêmicas são capazes de predizer rejeição aguda do enxerto. MÉTODOS: Foram reavaliadas 1.012 biópsias endomiocárdicas consecutivas; dessas, 939 foram classificadas como OR ou 1R pela Nomenclatura da Sociedade Internacional de Transplante de Coração e Pulmão de 2005, e divididas em dois grupos: (1 Biópsias preditoras: aquelas que precederam rejeição aguda; e (2 Biópsias não preditoras: aquelas que não precederam rejeição aguda. Comparamos a ocorrência dos seguintes achados histológicos: vasculites, lesões isquêmicas, efeito Quilty e eosinófilos por análise uni e multivariada entre os grupos. RESULTADOS: Após análise estatística verificou-se a presença de vasculite intensa e de eosinófilos como maiores preditores para rejeição aguda futura, apresentando respectivamente as seguintes razões de chance: 10,60 (IC95%: 3,62 - 31,06. p FUNDAMENTO: El significado clínico de vasculitis, lesiones isquémicas, efecto Quilty y de la presencia de eosinófilos en biopsias endomiocárdicas de receptores de transplante cardíaco con rechazos leves no fue aun establecido. OBJETIVO: Verificar si esos hallazgos histológicos encontrados en las biopsias endomiocárdicas (eosinófilos, vasculitis, efecto Quilty y lesiones isquémicas son capaces de predecir rechazo agudo del injerto. MÉTODOS: Fueron reevaluadas 1.012 biopsias endomiocárdicas consecutivas; de esas, 939 fueron clasificadas como OR o 1R por la Nomenclatura de la Sociedad Internacional de Transplante de Corazón y Pulmón de 2005, y divididas en dos grupos: (1 Biopsias predictoras: aquellas que

  2. AISLAMIENTO Y CARACTERIZACION DE UNA LEVADURA FLOCULANTE PARA PRODUCIR ETANOL DEL BANANO DE RECHAZO

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    CARLOS GUEVARA-BRAVO

    Full Text Available Fue aislada y caracterizada una cepa de levadura Saccharomycescerevisiae LEG-06, con características floculantes para fermentar jugo de banano extraído bajo condiciones básicas. Los rendimientos de etanol fueron comparados con levaduras comerciales y además fueron evaluados los efectos del pH y del agente neutralizante. Adicionalmente se evaluó el efecto sobre la eficiencia de 10 fermentaciones sucesivas usando la misma levadura. Finalmente, se escaló la fermentación a 40 L en reactor tubular con agitación mecánica y se determinaron los parámetros cinéticos de la levadura. Las condiciones ideales fueron: pH 5,5 utilizando ácido cítrico como neutralizante, 23,8 g/L de levadura, 14,5°Brix. La eficiencia estuvo entre 82-84% y el pH óptimo de floculación entre 5,5 y 6,0. La concentración de etanol obtenido en las mejores condiciones alcanzó el 7,5%. Estos resultados demuestran la levadura como la metodología usada, presentan las características adecuadas y deseadas para desarrollar un proceso a nivel de planta piloto para la producción de etanol a partir de banano de rechazo.

  3. El Cristianismo en la metáfora del rechazo y la integración

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    Jaime ALVAR

    2009-10-01

    Full Text Available RESUMEN: En este artículo se analizan los documentos procedentes de la literatura neotestamentaria que permiten descubrir los mecanismos de integración social, así como del rechazo real y metafórico que suscita el cristianismo desde sus orígenes hasta el triunfo de la Iglesia. La extirpación de los primeros seguidores de su entorno social constituye un ejemplo referencial en la tensión desintegradora que, a la postre, habría de convertirse en una formulación retórica para el éxito del discurso cristiano en el marco ideológico del poder imperial refundado tras la Tretarquía. Al mismo tiempo, se analiza la función excluyente del cristianismo frente al judaísmo en el que nace y su posterior capacidad de integración social de los judíos de la diáspora, cuando el cristianismo se había reconvertido en romanitas.ABSTRACT: The New Testament texts allow searching the mechanism for the social integration, as well as the reject –real and metaphorical– raised by the Christianism from its origins until the Triumph of the Church. The extirpating of the first followers from their social environment is a basic reference for the disintegrating force that finally became mere rhetoric for the success of Christianism in the Tetrarchy’s aftermath. In addition this paper analyses the Christian refuse of the actual Judaism and its later ability to integrate in the Romanitas the Jewish diaspora.

  4. HIDRÓLISIS ENDO-ENZIMATICA Y PRODUCCION DE ETANOL A PARTIR DEL BANANO DE RECHAZO

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    CARLOS A GUEVARA-BRAVO

    Full Text Available Los polisacáridos del banano de rechazo verde (Variedad Cavendish AAA, de la zona de Urabá, fueron hidrolizados eficientemente, utilizando tratamiento endoenzimático a altas temperaturas. Posteriormente los azúcares simples fueron extraídos y los jugos resultantes fermentados con levaduras comerciales. Al final del proceso se determinó la concentración de etanol y se calcularon los rendimientos. Primero, se desarrollaron experimentos a escala de 1,0 Kg y se determinaron las mejores condiciones de hidrólisis: Concentración de etileno exógeno (50 ppm, temperatura (33°C y cantidad de Ca(OH2 (10 g/Kg de banano, adecuada para la extracción. Teniendo como referencias las condiciones anteriores, fue escalado el proceso a 40 Kg, para determinar la metodología de extracción de los azúcares (en contracorriente, mediante la utilización de lechada de cal (1,0%, para precipitar los sólidos, centrifugación y posterior neutralización con H2SO4 hasta pH 5,5. Finalmente los jugos ricos en azúcares fueron fermentados con levaduras a 5 g/L, donde se alcanzó un rendimiento de 52 mL de etanol/Kg de banano. Estos resultados indican que el proceso es promisorio para producir alcohol a gran escala, Sin embargo se debe mejorar, para que sea competitivo con los rendimientos obtenidos con de caña de azúcar (86 mL de etanol/Kg de caña.

  5. El sólido hiperbólico agudo

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    Rosa María Herrera

    2012-04-01

    Full Text Available Torricelli consideró el cálculo del volumen de sólido hiperbólico agudo como el mejor logro en sus trabajos con ‘indivisibles curvos’. Fue publicado en la Opera geometrica. Aquí se presenta como muestra del estilo de las demostraciones matemáticas (geométricas que se efectuaban en el siglo XVII, y por su valor precursor del cálculo infinitesimal. Es un ejemplo significativo para aproximarse al pensamiento torricelliano.

  6. Estado Confusional Agudo nas Unidades de Cuidados Intensivos

    OpenAIRE

    Santos, L; Alcântara, J

    1996-01-01

    As alterações do comportamento frequentemente observadas em doentes internados nas unidades de cuidados intensivos (UCI), podem ser adequadamente designadas, na maioria das vezes, por estado confusional agudo, o qual se caracteriza por: flutuação do estado de vigília, distúrbio do ciclo vigília-sono, défice de atenção e concentração, desorganização do pensamento, manifestado entre outras formas por discurso incoerente, distúrbios da percepção sob a forma de ilusões e/ou alucinações, desorient...

  7. Teoría de la Aceptación-Rechazo Interpersonal (IPARTheory: bases conceptuales, método y evidencia empírica

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    Ronald P. Rohner

    2014-12-01

    Full Text Available La teoría de aceptación-rechazo interpersonal (IPARTheory es una teoría basada en la evidencia que trata de predecir y explicar las principales causas, consecuencias y correlatos de la aceptación-rechazo -especialmente parental- a lo largo del ciclo vital. Esta teoría se divide en tres subteorías: subteoría de la personalidad (todos los niños y niñas independientemente de su contexto sociocultural, racial o étnico responden esencialmente en el mismo sentido cuando perciben que son rechazados o aceptados por sus padres u otras figuras de apego; subteoría del afrontamiento (determinados factores individuales proporcionan tanto a niños como a adultos la fortaleza de afrontar más eficazmente las experiencias de rechazo; y subteoría de los sistemas socioculturales (el rechazo parental ocurre en un contexto ecológico, más global, que abarca la familia, la comunidad y en un entorno sociocultural. El método en la IPARTheory se caracteriza por utilizar una estrategia multimétodo desde una perspectiva transcultural, y por proveer un marco conceptual para integrar los estudios empíricos sobre aceptación-rechazo interpersonal desde una perspectiva del ciclo vital.

  8. Tratamiento del dolor agudo en el paciente dependiente de sustancias

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    DR. B. Juan Pablo Acuña

    2014-07-01

    Full Text Available El manejo del dolor agudo del paciente dependiente de sustancias, es un desafío para el profesional encargado de otorgar alivio a su síntoma. La dependencia de sustancias es reconocida como una enfermedad cerebral primaria crónica y recurrente. Su neurobiología y mecanismos fisiopatológicos de adaptación a la sustancia generan cambios en la percepción del dolor, en la respuesta a analgésicos opioides y cambios conductuales que interfieren con el tratamiento del dolor. Un conocimiento básico y claro respecto de lo descrito permite diseñar estrategias seguras y eficaces de alivio del dolor, sin interferir el curso de la enfermedad adictiva. Artículos de revisión, recomendaciones y guías elaboradas por expertos coinciden en que el tratamiento más eficaz del dolor incluye un manejo multimodal, un enfoque multidisciplinario, mantención de la terapia de sustitución y una estrecha vigilancia durante el episodio agudo de dolor y su seguimiento posterior.

  9. Efeitos do exercicio agudo sobre biomarcadores sericos de ratos diabeticos

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    Fabio Milioni

    2014-01-01

    Full Text Available INTRODUÇÃO: As respostas ao exercício agudo dos biomarcadores, como a fosfatase alcalina (FA e a creatina quinase (CK séricas têm sido pouco investigadas em ratos diabéticos. OBJETIVOS: Verificar os efeitos do exercício físico aeróbio agudo sobre as concentrações de CK e FA, bem como, avaliar o estado hídrico em ratos diabéticos experimentais. MATERIAIS E MÉTODOS Foram utilizados ratos Wistar machos, adultos jovens, distribuídos em dois grupos: diabéticos (DA e controles (CA. O diabetes foi induzido por meio da administração de aloxana monoidratado Sigma(r (32 mg/kg de peso corporal. Duas semanas após confirmação do diabetes, ambos os grupos foram submetidos a uma sessão aguda de natação por 30 min, com carga aeróbia (4,5 % do peso corporal. Foram avaliados: glicose, hematócrito, CK, FA, albumina e a cinética de lactato durante o exercício por meio de coletas 25 µL de sangue da cauda dos animais, nos minutos 0, 10, 20 e 30 de exercício. RESULTADOS: ANOVA de dois fatores para medidas repetidas e o teste post hoc de Tukey apontaram diminuição significativa dos valores de glicemia após o exercício para o grupo DA, aumento significativo de CK pós-exercício para o grupo DA, aumento significativo de hematócrito para ambos os grupos após exercício e manutenção da FA após exercício para o grupo DA. CONCLUSÃO: O exercício agudo aeróbio foi eficiente no controle dos níveis glicêmicos de ratos diabéticos. Entretanto, deve ser aplicado com cautela, pois induziu altos valores de CK, sugerindo possíveis lesões teciduais.

  10. Doença periodontal e infarto agudo do miocardio

    OpenAIRE

    Coelho, Julita Maria Freitas

    2010-01-01

    p. 1-98 Dados epidemiológicos, experimentais e clínicos têm sugerido que a doença periodontal, especialmente a periodontite crônica, pode constituir um fator de risco para doenças cardiovasculares isquêmicas. A proposta deste estudo foi investigar a associação entre a doença periodontal e o infarto agudo do miocárdio (IAM) em indivíduos adultos. Uma revisão de literatura de estudos de caso-controle que estudaram essa associação foi sumarizada em uma meta-análise que demonstrou uma chance e...

  11. Efeitos agudos da corrente interferencial ganglionar em mulheres sadias

    OpenAIRE

    Nakata, Cláudio Hiroshi

    2014-01-01

    OBJETIVO: Analisar os efeitos agudos da corrente interferencial ganglionar em mulheres sadias. MATERIAIS E MÉTODOS: Estudo do tipo experimental aleatorizado e transversal. Vinte e uma mulheres militares do Exército Brasileiro divididas em dois grupos, conforme IPAQ, em ativas (média de idade de 32,80 ± 3,011 anos, massa 56,50 ± 5,523 Kg, estatura de 164,30 ± 6,993 cm e IMC de 20,90 ± 1,729 kg/m2 e 80% com conceito excelente no teste de aptidão física) e irregularmente ativas (média de idade d...

  12. Terapia com células-tronco na síndrome do desconforto respiratório agudo Stem cell therapy in acute respiratory distress syndrome

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    Tatiana Maron-Gutierrez

    2009-03-01

    Full Text Available A síndrome do desconforto respiratório agudo é caracterizada por uma reação inflamatória difusa do parênquima pulmonar, podendo ser induzida por um insulto direto ao epitélio alveolar (síndrome do desconforto respiratório agudo pulmonar ou indireto através do endotélio vascular (síndrome do desconforto respiratório agudo extrapulmonar. Acredita-se que uma terapia eficaz para o tratamento da síndrome do desconforto respiratório agudo deva atenuar a resposta inflamatória e promover adequado reparo da lesão pulmonar. O presente artigo apresenta uma breve revisão acerca do potencial terapêutico das células-tronco na síndrome do desconforto respiratório agudo. Essa revisão bibliográfica baseou-se em uma pesquisa sistemática de artigos experimentais e clínicos sobre terapia celular na síndrome do desconforto respiratório agudo incluídos nas bases de dados MedLine e SciELO nos últimos 10 anos. O transplante de células-tronco promove melhora da lesão inflamatória pulmonar e do conseqüente processo fibrótico, induzindo adequado reparo tecidual. Dentre os mecanismos envolvidos, podemos citar: diferenciação em células do epitélio alveolar e redução na liberação de mediadores inflamatórios e sistêmicos e fatores de crescimento. A terapia com células-tronco derivadas da medula óssea pode vir a ser uma opção eficaz e segura no tratamento da síndrome do desconforto respiratório agudo por acelerar o processo de reparo e atenuar a resposta inflamatória. Entretanto, os mecanismos relacionados à atividade antiinflamatória e antifibrogênica de tais células necessitam ser mais bem elucidados, limitando, assim, o seu uso clínico imediato.Acute respiratory distress syndrome is characterized by an acute pulmonary inflammatory process induced by the presence of a direct (pulmonary insult that affects lung parenchyma, or an indirect (extrapulmonary insult that results from an acute systemic inflammatory response

  13. Avaliação do peptídeo natriurético tipo B no diagnóstico de rejeição após transplante cardíaco pediátrico Evaluación del péptido natriurético tipo B en el diagnóstico de rechazo tras transplante cardiaco pediátrico B-type natriuretic peptide assessment in the diagnosis of rejection after pediatric heart transplant

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    Cristina de Sylos

    2009-03-01

    Full Text Available FUNDAMENTO: A rejeição constitui-se em uma das principais causas de mortalidade após o transplante cardíaco pediátrico. O peptídeo natriurético tipo B (BNP tem sido estudado como método no diagnóstico de rejeição aguda, especialmente em pacientes adultos submetidos a transplante cardíaco. OBJETIVO:Correlacionar o nível sérico de BNP à rejeição aguda diagnosticada pela biópsia endomiocárdica em pacientes do grupo de transplante cardíaco pediátrico. MÉTODOS:Foram coletadas 50 amostras de BNP de 33 crianças em pós-operatório de transplante cardíaco e analisados dados de idade, sexo, cor, grupo sangüíneo, painel imunológico, tempo de evolução após o transplante, classe funcional, imunossupressão utilizada e número de rejeições. RESULTADOS:Foram 33 crianças com idade mediana de 10,13 anos, predomínio do sexo feminino (54% e da cor branca (78%. No momento da dosagem de BNP o tempo médio de transplante foi 4,25 anos. A biópsia endomiocárdica diagnosticou nove rejeições em oito pacientes (27%, sendo três com grau 3 A, cinco com grau 2 e um com rejeição humoral. No momento da biópsia, a maioria dos pacientes encontrava-se assintomática. O nível sérico de BNP foi em média 77,18 pg/ml, sendo 144,22 pg/ml no grupo com rejeição e 62,46 pg/ml no grupo sem rejeição, com p = 0,02. CONCLUSÃO: Crianças assintomáticas podem apresentar rejeição aguda no pós-operatório de transplante cardíaco. O nível sérico de BNP apresentou diferença estatisticamente significante no grupo com rejeição, podendo ser método adicional no diagnóstico de rejeição cardíaca.FUNDAMENTO: El rechazo constituye una de las principales causas de mortalidad tras el transplante cardiaco pediátrico. El péptido natriurético tipo B (BNP ha sido estudiado como método en el diagnóstico de rechazo agudo, sobre todo en pacientes adultos sometidos a transplante cardiaco. OBJETIVO:Correlacionar el nivel sérico de BNP al rechazo

  14. Rechazo y victimización al alumnado con necesidad de apoyo educativo en primero de primaria

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    Mª Inés Monjas

    2014-05-01

    Full Text Available Este estudio pretende analizar el rechazo y victimización social que experimenta el alumnado con necesidad de apoyo educativo en comparación con sus compañeros. Participaron 1351 alumnos de primero de educación primaria de los que 253 (el 18.7% fueron etiquetados por sus profesores como alumnos con necesidad de apoyo educativo ya que presentaban dificultades que hicieron necesaria ayuda educativa especial y adicional al resto de compañeros. La información ha sido proporcionada por los iguales (tipología sociométrica, reputación social y calificación sociométrica, el profesorado (competencia social y el propio alumno (victimización y competencia percibida. Los resultados indican que los alumnos con necesidad de apoyo educativo son más rechazados, tienen peor reputación social (más agresivos, más aislados y menos prosociales y sus profesores les califican como menos competentes socialmente. Informan de que son victimizados con más frecuencia que sus compañeros y se autoperciben como menos competentes cognitivamente y menos aceptados por sus iguales. Todo ello revela una evidente caracterización de este alumnado como rechazado y excluido. Es más, los aspectos que definen el perfil del rechazo se ven intensificados cuando se trata de estos alumnos, motivos por los que se concluye con la necesidad de prestar especial atención y cuidado a este colectivo en riesgo.

  15. Controvérsias acerca da acidose hipercápnica na síndrome do desconforto respiratório agudo Controversies involving hypercapnic acidosis in acute respiratory distress syndrome

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    Liliane Nardelli

    2009-12-01

    Full Text Available A síndrome do desconforto respiratório agudo é caracterizada por uma reação inflamatória difusa do parênquima pulmonar induzida por um insulto direto ao epitélio alveolar (síndrome do desconforto respiratório agudo pulmonar ou indireto por meio do endotélio vascular (síndrome do desconforto respiratório agudo extrapulmonar. A principal estratégia terapêutica da síndrome do desconforto respiratório agudo é o suporte ventilatório. Entretanto, a ventilação mecânica pode agravar a lesão pulmonar. Nesse contexto, uma estratégia ventilatória protetora com baixo volume corrente foi proposta. Tal estratégia reduziu a taxa de mortalidade dos pacientes com síndrome do desconforto respiratório agudo, porém acarretou acidose hipercápnica. O presente artigo apresenta uma revisão da literatura acerca dos efeitos da acidose hipercápnica na síndrome do desconforto respiratório agudo. Para tal, realizou-se uma revisão sistemática da literatura científica conforme critérios já estabelecidos para análise documental incluindo artigos experimentais e clínicos sobre o tema, usando-se como bases de dados MedLine, LILACS, SciElo, PubMed, Cochrane. A acidose hipercápnica é defendida por alguns autores como moduladora do processo inflamatório da síndrome do desconforto respiratório agudo. Entretanto, estudos clínicos e experimentais acerca dos efeitos da acidose hipercápnica têm demonstrado resultados controversos. Logo, é fundamental a realização de mais pesquisas para elucidar o papel da acidose hipercápnica na síndrome do desconforto respiratório agudo.Acute respiratory distress syndrome is characterized by a diffuse inflammatory reaction of lung parenchyma induced by a direct insult to the alveolar epithelium (pulmonary acute respiratory distress syndrome or an indirect lesion through the vascular endothelium (extrapulmonary acute respiratory distress syndrome. The main therapeutic strategy for acute respiratory

  16. Infarto agudo de miocardio inducido por heroína

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    Beatriz Wills

    2014-09-01

    Full Text Available El uso mundial de drogas recreativas ha alcanzado proporciones preocupantes, al punto de amenazar la estabilidad socioeconómica de los países. Se estima que en los países desarrollados una de cada 4 personas ha utilizado drogas recreativas en algún momento de su vida. Por tanto, es frecuente que los médicos se enfrenten a cuadros de intoxicación secundaria al abuso de estas drogas. Además de sus efectos en el sistema nervioso central, también producen cambios significativos a nivel cardiovascular, responsables de una cantidad no despreciable de morbimortalidad relacionada con estas. En este artículo se expone un caso de infarto agudo de miocardio secundario al consumo de heroína, se revisan los efectos sistémicos de esta droga y se examinan el manejo y los mecanismos estudiados que explican esta relación.

  17. Síndrome coronario agudo con supradesnivel del ST asociado al feocromocitoma con las catecolaminas inicialmente normales

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    Jorge M. Pacheco

    2016-01-01

    Full Text Available Los feocromocitomas son tumores secretores de catecolaminas que cursan con paroxismos de hipertensión o hipotensión arterial y palpitaciones. Son una causa rara del síndrome coronario agudo. Presentamos el caso de una paciente con síndrome coronario agudo secundario a feocromocitoma que inicialmente tenía valores normales de catecolaminas.

  18. Síndrome coronario agudo con supradesnivel del ST asociado al feocromocitoma con las catecolaminas inicialmente normales

    OpenAIRE

    Pacheco, Jorge M.; Pérez Baztarrica, Gabriel; Díaz Bozio, Fernando; Jiménez, Andrés; Porcile, Rafael

    2016-01-01

    Los feocromocitomas son tumores secretores de catecolaminas que cursan con paroxismos de hipertensión o hipotensión arterial y palpitaciones. Son una causa rara del síndrome coronario agudo. Presentamos el caso de una paciente con síndrome coronario agudo secundario a feocromocitoma que inicialmente tenía valores normales de catecolaminas.

  19. Abdomen agudo quirúrgico en el anciano

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    Jesús M Valdés Jiménez

    2002-04-01

    Full Text Available Se presenta un estudio descriptivo retrospectivo de 156 enfermos mayores de 65 años, con diagnóstico de abdomen agudo quirúrgico (AAQ, operados en el Hospital Clinicoquirúrgico «Manuel Fajardo» e ingresados en la Unidad de Cuidados Intermedios Polivalente, durante el trienio comprendido entre 1995 y 1998. Las causas más frecuentes del síndrome fueron la oclusión intestinal (58,9 %, la colecistitis aguda (13,5 % y la úlcera péptica gastroduodenal perforada (10,9 %. Las enfermedades asociadas de mayor prevalencia eran la cardiopatía isquémica (62,2 % y la hipertensión arterial (48,7 %. La mortalidad aumentó con el avance de la edad, y alcanzó el 70,4 % en los mayores de 85 años. Entre las complicaciones predominaron la infección de la herida quirúrgica (12,8 % y la bronconeumonía (5,8 %. La principal causa de muerte fue la sepsis (10,3 %A descriptive and retrospective study of 156 patients over 65 with diagnosis of acute surgical abdomen (ASA that were operated on at "Manuel Fajardo" Clinical and Surgical Hospital and admitted at the Polyvalent Intermediate Care Unit, from 1995 to 1998, was conducted. The most common causes of the syndrome were intestinal occlusion (58.9 %, acute cholecystitis (13.5 % and the gastroduodenal perforated peptic ulcer (10.9 %. The associated diseases of highest prevalence were ischemic heart disease (62.2 % and arterial hypertension (48.7 %. Mortality increased with age and amounted to 70.4 % in patients over 85. The infection of the surgical wound (12.8 % and bronchopneumonia (5.8% prevailed among the complications. Sepsis (10.3 % was the main cause of death

  20. Abdome agudo por obstrução por ileobiliar

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    Márcia Cristina de Alencastro

    Full Text Available OBJETIVO: descrever a experiência na abordagem dos doentes com abdome agudo por obstrução por IB, desde o diagnóstico até o tratamento definitivo. MÉTODOS: estudo retrospectivo incluindo todos os casos de IB tratados em um período de 23 anos. De acordo com a abordagem cirúrgica realizada, os pacientes foram divididos em dois grupos (1 enterolitotomia com colecistectomia no segundo momento; e (2 enterolitotomia, colecistectomia e abordagem da fístula. RESULTADOS: Doze pacientes foram incluídos, sendo 11 mulheres (91,6%, com média de idade de 72,2 anos. Todos os pacientes apresentavam doenças associadas, principalmente hipertensão arterial sistêmica (75%. Dois pacientes não apresentavam sintomas significativos de obstrução intestinal. O diagnóstico de IB foi realizado em seis pacientes (50% antes da laparotomia. O grupo 1 foi constituído de oito pacientes e o grupo 2 de quatro, e a morbidade foi, respectivamente, 33,3% e 8,3%. A mortalidade foi 16,6% (um paciente de cada grupo. CONCLUSÃO: O manejo do IB deve ser individualizado. O tratamento da obstrução mediante remoção do cálculo biliar por enterotomia proximal é a escolha inicial para o tratamento do IB. A colecistectomia e a correção da fístula bilioentérica podem ser realizadas juntamente com a remoção do cálculo, no entanto, em pacientes com comorbidades significativas, esses procedimentos devem ser realizados posteriormente.

  1. Abdome agudo obstrutivo pela veia porta - relato de caso

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    Celeste Gomes Sardinha Oshiro

    2016-10-01

    Full Text Available Introdução: A veia porta pré-duodenal é uma anomalia congênita rara, sintomática em apenas 50% dos casos, sendo que seu diagnóstico é feito por laparotomia exploradora. O tratamento de escolha é cirúrgico, com bom prognóstico. Objetivo: Relatar um caso de Abdome Agudo Obstrutivo por Veia Porta Pré Doudenal (VPPD no período neonatal no Conjunto Hospitalar de Sorocaba. Metodologia: Descrição do referido caso e revisão de literatura. Relato de Caso: Recém-nascido de F.S.S., feminino, de parto normal em 30/05/2016, cuja mãe com 21 anos, apresentou durante pré-natal Diabetes Mellitus Gestacional e polihidrâmnio; negou consanguinidade, vícios e infecções. Ao nascimento, idade gestacional 38 1/7 semanas, peso 2865g, comprimento 47 cm, Apgar 9/9. Durante rotinas de sala de parto, à aspiração gástrica, saída de 55 ml de líquido claro com grumos (LCCG. No 4o dia de vida, episódios de vômito com sangue e distensão abdominal. No 11° dia de vida, realizada Laparotomia Exploradora que identificou dilatação gástrica e duodenal, principalmente na 3° porção, onde passa anteriormente a Veia Porta, comprimindo parcialmente a borda antimesentérica duodenal, o que comprometia seu esvaziamento. Realizada anastomose duodeno-jejunal. Recebeu alimentação parenteral por 15 dias. RN apresentou infecções fúngica e bacteriana, tratadas durante internação. Recebe alta com 46 dias de vida em aleitamento materno e boa recuperação clínica. Conclusão: Existem poucos relatos sobre a formação anômala da veia porta e suas consequências. O diagnóstico pré-natal ou pré-operatório de VPPD raramente é feito. Boa evolução pós correção cirúrgica.

  2. Trombolisis en el infarto agudo del miocardio en servicio de emergencias

    Directory of Open Access Journals (Sweden)

    Alexander del Toro Cámbara

    2013-12-01

    Full Text Available Introducción: las enfermedades cardiovasculares y dentro de estas, el infarto agudo del miocardio han sido el mayor problema de salud y la principal causa de muerte en muchos países del mundo durante varias décadas. Objetivo: determinar la efectividad de la estreptoquinasa recombinante cubana en la morbilidad y mortalidad del infarto agudo del miocardio. Material y método: se realizó una investigación observacional, descriptiva y transversal en los pacientes con diagnóstico de Infarto Agudo del Miocardio, que acudieron al servicio de emergencias del Policlínico Universitario Pedro Borrás, entre septiembre 2009 y agosto 2010. El universo lo integraron 56 pacientes con síndrome coronario agudo con elevación del ST, y la muestra 42 pacientes trombolizados. Las técnicas de procesamiento y análisis fueron la distribución en frecuencias absolutas y relativas y la prueba de ji cuadrado. Resultados: predominaron los pacientes del sexo masculino y edades comprendidas entre 45 y 60 años. Prevaleció la implantación del tratamiento por debajo de las seis horas, siendo tratados un número pequeño de pacientes durante la primera hora, efectiva en todos los casos. Sobresalieron como reacciones adversas la hipotensión arterial y las contracciones auriculares y ventriculares prematuras. Preponderó la desaparición del dolor y regresión de los cambios isquémicos electrocardiográficos como criterios de reperfusión. Conclusiones: el uso de la estreptoquinasa recombinante cubana contribuyó a disminuir la mortalidad en pacientes con infarto agudo al miocardio quedando así demostrado su efectividad.

  3. Procedimiento de obtención de materailes multifuncionales y renovables a partir del rechazo de pipa procedente de la producción de aceite de girasol

    OpenAIRE

    Martín-Luengo, María Ángeles; Yates Buxcey, Malcolm; Ramos, M.; Sáez Rojo, Eduardo; González Gil, Lorena; Martínez Serrano, Ana María; Martín-Aranda, Rosa María; Sanz Lázaro, Jesús

    2011-01-01

    Procedimiento de obtención de materiales multifuncionales y renovables a partir del rechazo de pipa procedente de la producción de aceite de girasol. La presente invención se refiere al procedimiento de obtención de materiales renovables, a partir de residuos precedentes de la fabricación de aceite de girasol, para su uso como matrices biocompatibles en ingeniería de tejidos, administración controlada de sustancias de interés biológico (drogas, proteínas, genes, etc...

  4. Complicaciones mecánicas del infarto agudo de miocardio: aunque infrecuentes, potencialmente letales

    Directory of Open Access Journals (Sweden)

    Jerson Quitian Moreno

    2017-09-01

    Full Text Available Aunque la incidencia de complicaciones mecánicas en el infarto agudo de miocardio ha descendido después de la era de la intervención coronaria percutánea, la mortalidad sigue siendo significativa. La ruptura septal ventricular, la regurgitación mitral aguda y la ruptura de la pared libre del ventrículo izquierdo conforman el espectro de complicaciones mecánicas posteriores al infarto agudo de miocardio. La reparación quirúrgica es el pilar del tratamiento; sin embargo, como puente para la cirugía, el manejo médico permite estabilizar al paciente.

  5. FRACASO RENAL AGUDO EN EL PACIENTE ONCOLOGICO. ANALISIS CLINICO Y PRONOSTICO.

    Directory of Open Access Journals (Sweden)

    Purroy A,

    2004-01-01

    Full Text Available RESUMEN: El fracaso renal agudo es un problema frecuente en el paciente oncológico, que plantea limitaciones en el pronóstico y en el planteamiento terapeútico. El desarrollo de registros de pacientes oncológicos con fracaso renal agudo permite analizar el perfil clínico y plantear aspectos a desarrollar desde el punto de vista terapeútico y sobre todo preventivo. El empleo de determinados índices pronósticos como el ISI (Liaño o el de fallo multiorgánico permite evaluar mejor este perfil clínico. En nuestra experiencia el fracaso renal agudo en el paciente oncológico es una complicación frecuente y relacionada con el proceso de base. Mediante este registro de pacientes hemos identificado un perfil clínico de alto riesgo consistente en un paciente con un fallo renal asociado a un proceso infeccioso, con insuficiencia respiratoria, oligúrico y con una puntuación elevada de esos índices pronósticos.

  6. Síndromes coronarios agudos: epidemiología y diagnóstico

    Directory of Open Access Journals (Sweden)

    Carlos A. Cassiani M.

    2009-01-01

    Full Text Available Los síndromes coronarios agudos son un problema mayor de salud pública en todo el mundo. El síndrome coronario agudo (SCA incluye infarto agudo de miocardio (IAM, con o sin elevación del ST y la angina inestable. La incidencia anual de IAM es 565.000 nuevos eventos y 300.000 ataques recurrentes cada año. Los factores de riesgo para enfermedad cardíaca isquémica (ECI incluyen: tabaquismo, niveles elevados de lípidos séricos, hipertensión arterial, diabetes mellitus, obesidad mórbida, sedentarismo, bajo consumo diario de frutas y vegetales, consumo problemático de alcohol e índice psicosocial. La evaluación inicial de un SCA debe enfocarse en el disconfort toráxico, signos y síntomas asociados y factores de riesgo para SCA. Los marcadores biológicos de lesión miocárdica hoy no son fundamentales para decidir el manejo inicial, aunque han contribuido a una mayor sensibilidad del abordaje diagnóstico y aportan datos para el pronóstico de los pacientes.

  7. Más allá de la unilateralidad de la violencia: el rechazo kantiano a un pretendido derecho a la revolución

    Directory of Open Access Journals (Sweden)

    Julia Muñoz Velasco

    2016-06-01

    Full Text Available El presente ensayo tiene por finalidad mostrar que el rechazo de Kant a un pretendido derecho a la revolución no implica que una situación de injusticia deba ser necesariamente tolerada. En su lugar, el rechazo kantiano a un derecho a la revolución es explicado aquí por medio de la categoría de comunidad entendida como una construcción de relaciones de coexistencia recíprocas. El énfasis sobre el tipo de vínculo que implica la categoría de comunidad permite sostener que el requisito para cualquier restitución de justicia legítima es que dicha acción debe considerar a todos los integrantes de la comunidad. La revolución no puede cumplir con este requisito pues siempre supone un uso unilateral de la violencia que, aunque cuente con el apoyo mayoritario de un determinado grupo social, es tan sólo un tipo de coacción parcial que no puede representar legítimamente a una comunidad

  8. Aceptación-rechazo parental y perfiles de victimización y agresión en situaciones de bullying

    Directory of Open Access Journals (Sweden)

    Benito León-del-Barco

    2015-05-01

    Full Text Available Un área de estudio importante en el acoso escolar continúa siendo el análisis de las causas del fenómeno y de los factores que actuarían como protección/riesgo en los ámbitos culturales, sociales, personales, escolares y familiares. La familia puede ser clave como factor de protección o de riesgo en la aparición de situaciones de violencia escolar. Con este estudio mediante un análisis discriminante pretendemos determinar las relaciones entre los diferentes perfiles de victimización y agresión implicados en la dinámica bullying y la aceptación-rechazo que perciben los participantes de sus padres. La muestra total estaba formada por 700 adolescentes estudiantes, 43% mujeres y 57% varones con una media de edad de 13.98. Hemos utilizado el Cuestionario de Convivencia Escolar (Defensor del Pueblo, 2006 y la Escala de Afecto versión hijos, EA-H (Bersabé, Fuentes y Motrico, 2001. Nuestros resultados confirman que las víctimas se caracterizarían por percibir un mayor afecto y comunicación de sus madres. Los agresores y los agresores/víctimas por percibir rechazo y crítica, especialmente del padre y poco afecto y comunicación de sus madres.

  9. Efeito Agudo da Pressao Positiva Continua sobre a Pressao de Pulso na Insuficiencia Cardiaca Cronica

    Directory of Open Access Journals (Sweden)

    Monica Quintao

    2014-03-01

    Full Text Available Fundamento: Pacientes com insuficiência cardíaca (IC apresentam disfunção ventricular esquerda e redução da pressão arterial média (PAM. O aumento do estímulo adrenérgico causa vasoconstrição e resistência dos vasos, mantendo a PAM, enquanto aumenta a resistência vascular periférica e a rigidez dos vasos condutores. O aumento da pressão de pulso (PP reflete a complexa interação do coração com os sistemas arteriais e venosos. O aumento da PP é um importante marcador de risco em pacientes com insuficiência cardíaca crônica (ICC. A ventilação não invasiva (VNI tem sido utilizada para IC aguda descompensada para melhorar a congestão e a ventilação pelos efeitos respiratórios e hemodinâmicos. No entanto, nenhum desses estudos relatou o efeito da VNI na PP. Objetivo: O objetivo deste estudo foi determinar os efeitos agudos da VNI com CPAP (pressão positiva contínua nas vias aéreas sobre a PP em pacientes ambulatoriais com ICC. Métodos: Seguindo um protocolo randomizado, duplo-cego, cruzado e controlado com placebo, 23 pacientes com ICC (17 homens, 60 ± 11 anos, IMC 29 ± 5 kg/cm2, classes II e III da NYHA foram submetidos à CPAP via máscara nasal durante 30 minutos na posição reclinada. A pressão da máscara foi de 6 cmH2O, enquanto o placebo foi fixado em 0-1 cmH2O. PP e outras variáveis hemodinâmicas não invasivas foram avaliadas antes, durante e depois do placebo e do modo CPAP. Resultados: A CPAP diminuiu a frequência cardíaca de repouso (pré: 72 ± 9; pós 5 min: 67 ± 10 bpm , p < 0,01 e PAM (CPAP: 87 ± 11; controle 96 ± 11 mmHg , p < 0,05 pós 5 min. A CPAP diminuiu a PP (CPAP: 47 ± 20 pré para 38 ± 19 mmHg pós; controle: 42 ± 12 mmHg, pré para 41 ± 18 pós p < 0,05 pós 5 min. Conclusão: A VNI com CPAP diminuiu a pressão de pulso em pacientes com ICC estável. Ensaios clínicos futuros devem investigar se esse efeito está associado com melhora no desfecho clínico.

  10. Beriberi cardiovascular agudo (Shoshin-Beriberi Acute cardiovascular beriberi (shoshin-beriberi

    Directory of Open Access Journals (Sweden)

    Osvaldo D. López Gastón

    2002-08-01

    Full Text Available El beriberi, la deficiencia de tiamina (B1, fue referido en el siglo XVII en la literatura asiática, y pue de manifestarse por síntomas neurológicos (beriberi «seco» donde la neuropatía periférica y la debilidad muscular son los más destacados y/o síntomas cardiovasculares (beriberi «húmedo», con una variante «clásica» donde es predominante la insuficiencia cardíaca derecha con índice cardíaco (IC normal o alto y otra aguda o «shoshin-beriberi», caracterizada por insuficiencia biventricular, acidosis láctica e IC variable y que sin tratamiento precoz evoluciona al colapso vascular y la muerte. Se presenta una paciente de 58 años y antecedente de enolismo, con disnea, oliguria, sígnos de fallo cardíaco biventricular con patrón hiperdinámico, acidosis metabólica, disfunción tubular renal y lactacidemia de 5.6 mEq/L. El exámen neurológico mostró una polineuropatía sensitiva, simétrica y distal en MMII y deterioro cognitivo con sígnos frontales. Horas después de la administración de 100 mg de tiamina ev. se observó una manifiesta mejoría de los valores hemodinámicos y el estado ácido-base. Se concluye que si bien el beriberi cardiovascular agudo es de presentación infrecuente hay consenso en que además es subdiagnosticado. La presencia de acidosis láctica o cuadro de insuficiencia cardíaca de alto volumen minuto sin etiología manifiesta, en pacientes con riesgo de deficiencia de B1, es suficiente para hacer la prueba terapéutica.Beriberi (BB, thiamine deficiency, has been described in the Asian literature in the 17th century and is characterized by peripheral neuropathy and muscle weakness, also called «dry» beriberi (BB to differentiate it from «wet» BB, with essentially cardiovascular manifestations. Wet can be either «classic» wet BB in which signs and symptons of right-sided heart failure with normal or high cardiac output are the presenting features or the «shoshin» BB variant with severe

  11. Aplicación de las escalas de estratificación del riesgo en el diagnóstico de los síndromes coronarios agudos

    Directory of Open Access Journals (Sweden)

    John Jaime Sprockel Díaz

    2017-09-01

    Conclusiones: En una población de pacientes con alta probabilidad para el síndrome coronario agudo, las escalas HEART y TIMI mostraron una mayor capacidad para discriminar el diagnóstico del síndrome coronario agudo.

  12. BIORREFINERIA A PARTIR DE BANANO DE RECHAZO: UN SISTEMA INTEGRADO PARA LA CO-PRODUCCIÓN DE ETANOL, PROTEÍNA UNICELULAR, BIOGÁS Y COMPOST

    OpenAIRE

    GUEVARA-BRAVO, CARLOS A; ACEVEDO-RUIZ, JOSÉ M; PELÁEZ-JARAMILLO, CARLOS A

    2016-01-01

    La producción de etanol, proteína unicelular, biogás y compost a partir de banano de rechazo de la zona de Urabá, fue realizada bajo el concepto de una biorrefineria. Inicialmente el banano verde fue sometido a hidrólisis endógena para degradar los polisacáridos, después los azúcares fermentables fueron extraídos para obtener jugos con un contenido de sólidos solubles entre 14 y 16 °Brix. La fracción insoluble fue utilizada para la producción de compost. Los jugos fueron fermentados para obte...

  13. Frecuencia de infección por VIH en pacientes con episodio agudo de herpes zoster

    Directory of Open Access Journals (Sweden)

    Susana Lazarte Heraud

    2005-01-01

    Full Text Available Objetivo: Evaluar la frecuencia de infección por VIH en pacientes que consultan por episodio agudo de herpes zoster. Material y Métodos: Se incluyeron a todos los pacientes entre 18 y 49 años, atendidos entre setiembre del 2001 y enero del 2003 en el Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas del Hospital Nacional Cayetano Heredia, por un cuadro agudo de herpes zoster, diagnosticado clínicamente. Los criterios de inclusión fueron: status VIH desconocido tanto del paciente como de su pareja; que no presentaran alguna complicación neurológica o presentación atípica de zoster y que no tuvieran signos ni síntomas compatibles con infección por VIH (muguet oral, diarrea crónica, síndrome de desgaste, etc.. Previa firma de consentimiento informado, se tomó muestra de sangre para prueba de ELISA para VIH1. A todos los pacientes con resultado positivo se les realizó western blot. Resultados: Veintiún pacientes cumplieron los criterios del estudio, 14 varones y 7 mujeres. Cinco pacientes (23,8% fueron VIH positivos. De éstos, 4 fueron varones (4/14 y 1 mujer (1/7. No se encontró diferencias significativas en cuanto a la conducta sexual de riesgo. Conclusiones: Se encuentra un porcentaje elevado de infección por VIH en adultos jóvenes que consultan en un hospital general por un cuadro agudo de herpes zoster, sin ningún otro signo ni síntoma de inmunosupresión, independientemente de conductas sexuales de riesgo. Nuestro hallazgo justifica un despistaje de VIH en adultos jóvenes con herpes zoster.

  14. Diagnóstico por imagem do tromboembolismo pulmonar agudo Imaging of acute pulmonary thromboembolism

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    C. Isabela S. Silva

    2004-10-01

    Full Text Available O diagnóstico do tromboembolismo pulmonar agudo é baseado na probabilidade clínica, uso do dímero D (quando disponível e na avaliação por imagem. Os principais métodos de imagem utilizados no diagnóstico são representados por cintilografia ventilação-perfusão, angiografia pulmonar e tomografia computadorizada (TC. Na última década vários estudos têm demonstrado que a TC espiral apresenta elevada sensibilidade e especificidade no diagnóstico de tromboembolismo pulmonar agudo. Uma melhor avaliação das artérias pulmonares tornou-se possível com a recente introdução dos equipamentos de TC espirais com multidetectores. Vários pesquisadores têm sugerido que a angiografia pulmonar por TC espiral deve substituir a cintilografia na avaliação de pacientes com suspeita clinica de tromboembolismo pulmonar agudo. Os autores discutem os principais métodos de imagem utilizados no diagnóstico de tromboembolismo pulmonar agudo enfatizando o papel da TC espiral.The diagnosis of acute pulmonary thromboembolism is based on the clinical probability, use of D-dimer (when available and imaging. The main imaging modalities used in the diagnosis are ventilation-perfusion (V/Q, scintigraphy, angiography, and computed tomography (CT. In the last decade several studies have demonstrated that spiral CT has a high sensitivity and specificity in the diagnosis of acute pulmonary thromboembolism. The evaluation of the pulmonary arteries has further improved with the recent introduction of multidetector spiral CT scanners. Various investigators have suggested that spiral CT pulmonary angiography should replace scintigraphy in the assessment of patients whose symptoms are suggestive of acute PE. This article discusses the role of the various imaging modalities in the diagnosis of acute pulmonary thromboembolism with emphasis on the role of spiral CT.

  15. Agentes trombolíticos en el infarto agudo del miocardio

    OpenAIRE

    Manuel Cué Brugueras

    1995-01-01

    Se presenta un revisión bibliográfica sobre los agentes trombolíticos y su uso en el infarto agudo del miocardio con el objetivo de actualizar a los farmacéuticos y otros profesionales de la salud en la terapéutica de este importante problema de salud a nivel internacional. Se revisaron las bases de datos MEDLINE (1985-9/1994), Excerpta Medica (1985-1993), Internacional Pharmaceutical Abstracts (1970-9/1993) y Predicast (1992-11/1993). En la revisión se abordan los beneficios y riesgos de la ...

  16. El infarto agudo de miocardio, un problema de salud pública

    OpenAIRE

    Caccavo, Alberto

    2010-01-01

    El infarto agudo de miocardio (IAM) es una causa importante de muerte en la Argentina. La mortalidad intrahospitalaria del IAM en la actualidad es de aproximadamente el 10%, al menos en los centros que participan en registros. Su tratamiento está orientado a la reperfusión de la arteria ocluida con angioplastia primaria o trombolíticos. Sin embargo, sólo un pequeño número de hospitales disponen de angioplastia primaria y reciben trombolíticos muchos menos pacientes que los que los requieren. ...

  17. El infarto agudo de miocardio, un problema de salud pública

    OpenAIRE

    Alberto Caccavo

    2010-01-01

    RESUMENEl infarto agudo de miocardio (IAM) es una causa importante de muerte en la Argentina. Lamortalidad intrahospitalaria del IAM en la actualidad es de aproximadamente el 10%, almenos en los centros que participan en registros.Su tratamiento está orientado a la reperfusión de la arteria ocluida con angioplastia primariao trombolíticos. Sin embargo, sólo un pequeño número de hospitales disponen deangioplastia primaria y reciben trombolíticos muchos menos pacientes que los que los requieren...

  18. Factores relacionados con la mortalidad intrahospitalaria en el infarto agudo del miocardio

    Directory of Open Access Journals (Sweden)

    Yanier Coll Muñoz

    2012-09-01

    Full Text Available Fundamento: la identificación de los factores relacionados con la mortalidad en el infarto agudo del miocardio representa un eslabón primordial en la evaluación inicial de los pacientes. Objetivo: identificar los factores relacionados con la mortalidad intrahospitalaria de los pacientes con infarto agudo del miocardio, ingresados en la Unidad de Cuidados Intensivos Coronarios de Cienfuegos durante el año 2010. Método: se realizó un estudio de serie de casos, que incluyó 241 pacientes con diagnóstico de infarto agudo del miocardio, ingresados en la Unidad de Cuidados Intensivos Coronarios del Hospital General Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos, en el año 2010. Las variables que se analizaron fueron: edad, sexo, antecedentes patológicos personales, tipo de infarto agudo del miocardio (según electrocardiograma y localización topográfica, frecuencia cardiaca y tensión arterial al ingreso, clasificación de la insuficiencia cardiaca según Killip Kimball, creatinina, glicemia, colesterol total, triglicéridos, CPK-MB, y eventos adversos cardiovasculares durante su estadía hospitalaria. Resultados: la edad media de los pacientes estudiados fue de 65,6 años, con predominio del sexo masculino. La hipertensión arterial, el tabaquismo y el infarto miocárdico previo fueron los antecedentes de mayor interés, predominan los pacientes sin insuficiencia cardiaca y fracción de eyección conservada. Los eventos adversos cardiovasculares más frecuentes fueron: la angina post-infarto, arritmias ventriculares malignas y el choque cardiogénico. Conclusiones: se encontró relación significativa con la mortalidad para la edad avanzada (>70 años, taquicardia, glicemia ≥7 mmol/l al ingreso, y la presentación de arritmias ventriculares y choque cardiogénico durante la evolución intrahospitalaria.

  19. Abdomen agudo ocasionado por apendicitis aguda de probable origen tuberculoso. Informe de un caso

    OpenAIRE

    Montiel-Jarquín, Álvaro José; Alvarado-Ortega, Iván; Romero-Figueroa, María del Socorro; Rodríguez-Pérez, Fabiola; Rodríguez-Lima, Felipe; Loria-Castellanos, Jorge

    2017-01-01

    RESUMEN Antecedentes: la apendicitis aguda tuberculosa es una enfermedad rara, constituye de 0,001 % a 0,01 % de las formas clínicas de tuberculosis. Se presenta un caso de apendicitis aguda probablemente tuberculosa como causa de abdomen agudo quirúrgico. Caso clínico: hombre de 29 años con cuadro de dolor abdominal leve a moderado que se intensificó y localizó en el hemiabdomen derecho, claudicación, febrícula, vómito, mal estado general, leucocitosis de 11 300/µL y neutrofilia de 91 %....

  20. INFARTO AGUDO DO MIOCÁRDIO: MANUAL DE ORIENTAÇÃO PARA O PACIENTE

    Directory of Open Access Journals (Sweden)

    Fernanda Carneiro Mussi

    Full Text Available Baseado em pesquisa das expectativas de 30 pacientes internados em unidade coronária, os autores apresentam um manual de orientação para o paciente com diagnóstico de Infarto Agudo do Miocárdio. O objetivo do manual é ser um complemento do tratamento dos pacientes com Infarto do Miocárdio, a principal causa de morte em nosso pais. É composto por informações sobre o que é a doença, os fatores de risco a ela associados, retorno as atividades e tratamento.

  1. Validez y confiabilidad de un instrumento de satisfacción del usuario con síndrome febril agudo

    OpenAIRE

    Tiga-Loza, Diana C; Villar-Centeno, Luis á; Güiza-Sanabria, Diana R; Martínez-Vega, Ruth A

    2010-01-01

    Objetivo Determinar la validez y la confiabilidad de un instrumento de satisfacción del paciente con Síndrome Febril Agudo en urgencias y consulta oportuna de la Red Pública de Bucaramanga. Métodos Estudio de evaluación de tecnologías diagnósticas en personas con Síndrome Febril Agudo entre el 2008 y 2009. Se diseñó un cuestionario telefónico a partir de 3 instrumentos en español. Se evaluó validez de contenido mediante sometimiento a expertos y a profesionales de salud y validez facial en un...

  2. Eficacia de la asociación paracetamol-metamizol vs. paracetamol-dexketoprofeno en manejo de dolor agudo postoperatorio

    OpenAIRE

    García Ramiro, M.; Alonso Guardo, L.; Matilla Álvarez, A.; Bartol Sevillano, R.; Vaquero Roncero, L. M.; Muriel Villoria, C.

    2013-01-01

    Objetivo: El uso de fármacos con mecanismos diferentes combinados entre sí para el tratamiento del dolor, en concreto del dolor agudo postoperatorio, forma parte fundamental de un tipo de analgesia llamada multimodal. El objetivo de este trabajo es evaluar la eficacia de la asociación de paracetamol más metamizol y compararla con la asociación de paracetamol más dexketoprofeno en dolor agudo postoperatorio. Métodos: Diseñamos un estudio prospectivo de intervención en el que se incluyeron 42 p...

  3. Síndrome coronario agudo y enfermedad de Erdheim-Chester. Patogénesis e implicaciones terapéuticas

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    José Carlos Alarcón-García

    2017-05-01

    Full Text Available La enfermedad de Erdheim-Chester es una histiocitosis celular diferente a la histiocitosis de Langerhans, de origen incierto. Se caracteriza por una implicación multi-orgánica debida a la infiltración de los histiocitos CD68+/CD1a-, en forma de xantogranulomas, que afectan principal y comúnmente a la metáfisis y diáfisis de huesos largos. El diagnóstico se realiza mediante biopsia, donde se revelan histiocitos CD68+/CD1a-, carencia de proteína S, y presencia de gránulos de Birbeck. Se ha subestimado la implicación cardiovascular. Reportamos un caso de un varón de 67 años con la enfermedad de Erdheim-Chester e infarto de miocardio agudo, debido a implicación coronaria, además de enfermedad ósea, vascular, pituitaria y retroperitoneal. Revisamos la literatura relevante y describimos el tratamiento clínico de estos pacientes.

  4. Hiperglucemia en el síndrome coronario agudo: informe científico multidisciplinario

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    Patricia Blanco

    2012-04-01

    Full Text Available La hiperglucemia con o sin diabetes preexistente es un hallazgo frecuente en pacientes que cursan un síndrome coronario agudo. Estudios previos han demostrado que la hiperglucemia es altamente prevalente y se asocia a un mayor riesgo de muerte y complicaciones hospitalarias. Los mecanismos fisiopatológicos mediante los cuales la hiperglucemia provoca resultados adversos no son claros, y se desconoce si es un marcador de eventos o su causa. Los efectos perjudiciales de la hiperglucemia en el sistema cardiovascular son múltiples, y el control de los niveles de glucosa con insulina parece mejorar el pronóstico en estos pacientes. Se han desarrollado numerosos protocolos para el control de glucemia que demostraron ser seguros y efectivos. En una iniciativa originada en el Consejo de Emergencias de la Sociedad Argentina de Cardiología, se convocó a expertos de nuestro medio con el propósito de debatir estrategias para el control de la glucemia en pacientes que cursan un síndrome coronario agudo. Este documento refleja lo discutido en este evento académico con la intención de resumir los principales aspectos del control de la glucemia y ofrecer recomendaciones generales de tratamiento en la Unidad Coronaria.

  5. VASCULAR SURGERY

    African Journals Online (AJOL)

    2016-06-02

    Jun 2, 2016 ... with the literature from South Africa over the last four decades, and reflects the high rate of interpersonal violence in the country.14,15 As expected, cervical ... via the intact circle of Willis in young patients is the most likely explanation for the lack of strokes. Five patients were referred to the Durban vascular ...

  6. Vascular Disorders

    Science.gov (United States)

    ... All Topics A-Z Videos Infographics Symptom Picker Anatomy Bones Joints Muscles Nerves Vessels Tendons About Hand Surgery What is a Hand Surgeon? What is a Hand Therapist? Media Find a Hand Surgeon Home Anatomy Vascular Disorders Email to a friend * required fields ...

  7. Modelos de serviços hospitalares para casos agudos em idosos

    Directory of Open Access Journals (Sweden)

    Coelho Filho João Macedo

    2000-01-01

    Full Text Available Embora a atenção ao idoso seja uma prioridade emergente no Brasil, pouca ênfase tem sido dada a modelos de organização de serviços hospitalares para pacientes geriátricos. São revisados modelos de serviços hospitalares para admissão e manuseio de casos agudos em idosos, com ênfase na discussão sobre o papel e o posicionamento da medicina geriátrica (incluindo sua interface com especialidades e com a clínica médica no âmbito da atenção hospitalar. Foi realizada pesquisa na base de dados Medline (1989-1999, bem como nos principais livros-texto de geriatria e de gerontologia, buscando identificar descrições de serviços hospitalares para cuidado agudo de pacientes idosos. As características dos modelos identificados foram compiladas e descritas à luz de sua adequação à realidade dos serviços de saúde no Brasil. Exemplos de intervenções em geriatria, com efetividade demonstrada através de revisões sistemáticas, foram também citadas. Os modelos mais freqüentemente relatados foram cuidado prolongado, tradicional, baseado na idade cronológica, não especializado e integrado. Adaptações e variantes de alguns desses modelos foram freqüentemente relatadas, assim como seu impacto potencial na efetividade do cuidado geriátrico. Evidências sobre o melhor modelo a seguir não foram identificadas, mas aqueles modelos favorecendo a integração da geriatria com a clínica geral pareceram mais adequados à nossa realidade. Ressalta a necessidade de reestruturação de serviços de saúde para responder às novas demandas que surgem com o envelhecimento da população, bem como do delineamento de serviços hospitalares para casos agudos, importantes para a efetividade do cuidado geriátrico e que devem ser objeto de maior debate e pesquisa no Brasil.

  8. Tratamiento del adulto mayor con síndrome coronario agudo

    Directory of Open Access Journals (Sweden)

    Carolina Pemberthy-López

    2016-11-01

    Full Text Available El adulto mayor se encuentra en una etapa de la vida con cambios fisiológicos importantes que posee repercusiones directas e indirectas sobre su estado clínico, es así como el enfoque diagnóstico y terapéutico de sus patologías debe ser abordado desde una perspectiva diferente, con consideraciones especiales para este grupo poblacional. Lamentablemente, este grupo no ha sido bien representado en los diferentes estudios y por tanto, es mucho lo que desconocemos; su comportamiento y la eficacia de las distintas terapias no están bien establecidos. Teniendo de referencia el síndrome coronario agudo como principal causa de mortalidad en pacientes mayores de 65 años de edad, abordaremos esta entidad desde la evidencia que nos aportan algunos de los registros más importantes al respecto en adultos mayores.

  9. Hepatocarcinoma como causa de abdome agudo em adolescente: relato de caso

    Directory of Open Access Journals (Sweden)

    João Augusto dos Santos Martines

    2012-08-01

    Full Text Available O carcinoma hepatocelular (CHC é pouco prevalente nos países ocidentais, porém é um dos tumores mais freqüentes na Ásia e a quinta causa de câncer no mundo.É relatado um caso de adolescente do sexo feminino sem fatores de risco para um tumor extremamente agressivo, internada no Hospital Universitário da Universidade de São Paulo. A apresentação clínica foi de abdome agudo secundário a sangramento para cavidade peritoneal por ruptura do tumor evidenciado através de tomografia computorizada multidetectores (TCMD confirmado por laparotomia exploradora e biópsia hepática e tratada com rafia hemostática do parênquima hepático.

  10. BIORREFINERIA A PARTIR DE BANANO DE RECHAZO: UN SISTEMA INTEGRADO PARA LA CO-PRODUCCIÓN DE ETANOL, PROTEÍNA UNICELULAR, BIOGÁS Y COMPOST

    Directory of Open Access Journals (Sweden)

    CARLOS A GUEVARA-BRAVO

    Full Text Available La producción de etanol, proteína unicelular, biogás y compost a partir de banano de rechazo de la zona de Urabá, fue realizada bajo el concepto de una biorrefineria. Inicialmente el banano verde fue sometido a hidrólisis endógena para degradar los polisacáridos, después los azúcares fermentables fueron extraídos para obtener jugos con un contenido de sólidos solubles entre 14 y 16 °Brix. La fracción insoluble fue utilizada para la producción de compost. Los jugos fueron fermentados para obtener un fermento con contenidos de alcohol entre 7 y 8% v/v y adicionalmente proteína unicelular (levadura. La destilación del fermento produce una solución de etanol entre 40-50% como producto final y vinaza, que fue utilizada para la producción de biogás (3 m3 de biogás/m3 de vinaza. Este combustible, puede ser usado como fuente de energía en la misma destilación del fermento. Finalmente con los resultados, se realizaron estimaciones de la cantidad de los productos en un proceso a mayor escala.

  11. Variabilidad geográfica de las hospitalizaciones por infarto agudo al miocardio en Costa Rica

    Directory of Open Access Journals (Sweden)

    Melvin Morera Salas

    2014-01-01

    Full Text Available La presente investigación muestra los patrones geográficos de las hospitalizaciones por infarto agudo al miocardio en el seguro público de salud de Costa Rica en el trienio 2010-2012. Para el análisis geográfico por área de salud se utiliza un modelo bayesiano jerárquico espacial. Se estiman razones estandarizadas suavizadas y, como medida de precisión, la probabilidad de que cada área de salud registre un riesgo de hospitalización estadísticamente diferente al promedio nacional. En la determinación de presencia de autocorrelación espacial se utiliza el indicador de la I de Moran. La amplitud entre las variaciones observadas se estima mediante la razón interpercentil (percentil 95/percentil 5 y el coeficiente de variación. La tasa bruta de hospitalizaciones es de 5,8 por 10 mil habitantes en hombres y 2,6 / 10 mil en mujeres. Se registra un rango de variación de más de dos veces en las hospitalizaciones entre las áreas con mayores y menores egresos. Se presenta un patrón de bajas tasas de hospitalizaciones por infarto agudo al miocardio en áreas de salud fuera del Área Metropolitana, donde se encuentran los hospitales nacionales de mayor complejidad. Este elemento podría estar asociado a dificultades en el acceso de los servicios de hospitalización.

  12. Estreptoquinasa recombinante en pacientes con infarto agudo del miocardio. Cardiocentro de Camaguey, 2008

    Directory of Open Access Journals (Sweden)

    Héctor Mariño Cano

    2015-12-01

    Full Text Available Se realizó un estudio descriptivo longitudinal, con el objetivo de valorar la eficacia de la utilización de la Estreptoquinasa Recombinante en pacientes con Infarto Agudo de Miocardio (IMA en el Cardiocentro del Hospital Provincial Docente “Manuel Ascunce Doménech” en la provincia de Camagüey, en el período comprendido de enero a diciembre del 2008. El universo estuvo constituido por 200 pacientes, a los que se les diagnosticó Infarto Agudo de Miocardio y la muestra quedó formada por 80 pacientes que recibieron tratamiento trombolítico, las historias clínicas de los pacientes fueron la principal fuente de obtención de la información, utilizando  las  siguientes  variables: resultados criterio de perfusión, evolución clínica, criterio de reacciones adversas y la influencia que ejerce el tiempo puerta-aguja,  así como los cuidados de enfermería. Al terminar se observó que  el criterio de repercusión de mayor incidencia fue el eléctrico; la mayor cantidad de pacientes tuvieron buena evolución clínica; la hipotensión fue la reacción adversa más frecuente; el tiempo de puerta-aguja  que más incidió  fue el menor, de 3h; a todos los pacientes diagnosticados con infarto, que recibieron tratamiento trombolítico, se les  brindaron  cuidados de enfermería.

  13. Vascular ultrasound.

    Science.gov (United States)

    Pilcher, D B; Ricci, M A

    1998-04-01

    Surgeon-interpreted diagnostic ultrasound has become the preferred screening test and often the definitive test for the diagnosis of arterial stenosis, aneurysm, and venous thrombosis. As a modality for surveillance, its noninvasive quality makes it particularly appealing as the test of choice to screen patients for abdominal aortic aneurysms or to perform follow-up examinations on those patients with a carotid endartectomy or in situ bypass grafts. The increasing reliance on intraoperative duplex imaging of vascular procedures demands that the surgeon learn the skills to perform the studies without a technologist or radiologist to interpret the examination.

  14. Inestabilidad en múltiples placas ateroescleróticas en pacientes fallecidos por infarto agudo de miocardio

    Directory of Open Access Journals (Sweden)

    Ricardo A. Sarmiento

    2011-08-01

    Full Text Available Los procesos inflamatorios en los síndromes coronarios agudos juegan un rol importante en la inestabilidad de la placa ateroesclerótica. Nuestro objetivo fue evaluar la presencia y distribución de placas vulnerables e infiltrados inflamatorios en pacientes fallecidos por infarto agudo de miocardio y su comparación con los hallazgos en pacientes fallecidos por cuadros no coronarios. Se analizaron los estudios anatomopatológicos de corazón de 68 pacientes fallecidos por infarto agudo de miocardio y 15 fallecidos por causa no coronaria. Se registró la presencia de trombo, hemorragia intraplaca, ruptura endotelial e infiltrado inflamatorio. Al evaluar los pacientes fallecidos por IAM, encontramos trombo en 73.5% de las arterias responsables del IAM y en 28.7% de las no responsables (p < 0.0001. La hemorragia intraplaca se halló en el 70.5% de las arterias responsables y en 39.7% de las no responsables, p < 0.0001; ruptura endotelial en el 29.4% de las arterias responsables y en 3.7% de las no responsables, p < 0.0001. No encontramos diferencias en la presencia de infiltrado inflamatorio (76.5% versus 68.4%. Comparando con los fallecidos por causas no coronarias, la presencia de trombo fue significativamente superior (73.5% vs. 13.3%; p < 0.0001, así como la de hemorragia intraplaca (70.5% vs. 0%; p < 0.0001 y de infiltrado inflamatorio en las placas ateroescleroticas (76.5% vs. 46.6%; p = 0.021. En los pacientes fallecidos por infarto agudo de miocardio se observa inestabilidad de placa y actividad inflamatoria, no sólo en la arteria responsable del infarto sino también en las arterias no responsables del infarto.

  15. Actividad inflamatoria en múltiples placas ateroscleróticas en pacientes fallecidos por infarto agudo de miocardio

    Directory of Open Access Journals (Sweden)

    Alejandro García Escudero

    2009-01-01

    Full Text Available IntroducciónEstudios clínicos y anatomopatológicos sugieren que los procesos inflamatorios tienen un papel importante en la inestabilidad de la placa aterosclerótica, dado que en pacientes con síndromes coronarios agudos se observan infiltrados inflamatorios difusos en las arterias coronarias.ObjetivosEvaluar y localizar la distribución de placas vulnerables e infiltrados inflamatorios en pacientes fallecidos por infarto agudo de miocardio.Material y métodosMediante microscopia óptica se estudiaron las arterias coronarias de 58 pacientes fallecidos por infarto de miocardio. En las arterias coronarias relacionadas con el infarto y en las no relacionadas se registraron las siguientes variables: presencia de trombo, rotura de placa, hemorragia intraplaca y presencia de infiltrado inflamatorio.ResultadosAl analizar las diferencias existentes entre las arterias responsables del infarto y en las no responsables se encontraron diferencias significativas con respecto a la presencia de trombo (69% versus 38%; p < 0,008 y de hemorragia intraplaca (69% versus 50%; p < 0,03. No se encontró una diferencia significativa entre la arteria responsable y la no responsable al evaluar la presencia de infiltrado inflamatorio en las placas ateroscleróticas (77% versus 71%; p = ns.ConclusiónEn el infarto agudo de miocardio se comprobó la presencia de actividad inflamatoria que afectaba a más de un vaso, con compromiso de otras arterias además de la responsable del infarto. Se detectó también accidente agudo de placa en más de una arteria coronaria.REV ARGENT CARDIOL 2009;77:81-87.

  16. Hematoma subdural agudo espontâneo e hemorragia intracerebral em paciente com microangiopatia trombótica gestacional

    Directory of Open Access Journals (Sweden)

    Sâmia Yasin Wayhs

    2013-06-01

    Full Text Available Pré-eclâmpsia, síndrome HELLP (hemólise, elevação de enzimas hepáticas e plaquetopenia e fígado gorduroso agudo da gestação são as principais causas de microangiopatia trombótica e disfunção hepática grave durante a gestação, representando um spectrum do mesmo processo patológico. Relatou-se aqui o caso de uma gestante com 35 semanas internada em unidade de terapia intensiva no pós-operatório imediato de cesariana por morte fetal, com náuseas, vômitos e icterícia. Diagnosticaram-se pré-eclâmpsia pós-parto e fígado gorduroso agudo da gestação. Houve evolução tardia com hematoma subdural agudo e hemorragia intracerebral, sendo realizado tratamento neurocirúrgico. A paciente foi a óbito por anemia hemolítica refratária, com sangramento espontâneo em múltiplos órgãos. Pré-eclâmpsia, síndrome HELLP e fígado gorduroso agudo da gestação são processos patológicos que podem se sobrepor e se associar a complicações potencialmente fatais, como a hemorragia intracraniana aqui descrita. Sua detecção e diagnóstico precoces são fundamentais para a instituição de manejo adequado e sucesso do tratamento.

  17. Rotura de la pared libre del ventrículo izquierdo secundaria a infarto agudo de miocardio

    Directory of Open Access Journals (Sweden)

    Claudio Solís

    2009-01-01

    Full Text Available RESUMENAunque la terapia trombolítica y la angioplastia primaria han cambiado radicalmente elmanejo, la evolución y el pronóstico del infarto agudo de miocardio, la rotura de la paredlibre del ventrículo izquierdo todavía implica una tasa elevada de mortalidad.Si bien la mayoría de los pacientes con esta complicación presentan un cuadro agudo ycatastrófico, que se caracteriza por taponamiento cardíaco, disociación electromecánica ymuerte en pocos minutos, aproximadamente un tercio de ellos tienen una evolución subagudacon hipotensión sostenida y diversos grados de derrame pericárdico, lo que posibilita laimplementación de medidas terapéuticas necesarias como puente al tratamiento quirúrgicoresolutivo.En este trabajo se presenta una revisión actualizada de las características clínicas yecocardiográficas de los pacientes con rotura de la pared libre del ventrículo izquierdo asociadacon infarto agudo de miocardio, con el objetivo de destacar los puntos clave del diagnóstico e incrementar la sospecha clínica de una entidad grave, no siempre fatal.REV ARGENT CARDIOL 2009;77:395-404.

  18. Infarto Miocárdico Agudo: una perspectiva desde la Atención Primaria de Salud

    Directory of Open Access Journals (Sweden)

    Lianne Ramos Marrero

    Full Text Available Introducción: las enfermedades del corazón constituyen la primera causa de muerte a nivel mundial. Durante más de cuatro décadas, Cuba comportó similar estadística hasta el año 2012, a partir del cual el cáncer se situó como la primera causa de muerte; no obstante la enfermedades cardiovasculares constituyen un problema de salud de segundo orden para Cuba y dentro de este ítem el infarto miocárdico agudo como la principal causa de muerte. Objetivo: profundizar en el conocimiento sobre los elementos diagnósticos y de la conducta ante un infarto miocárdico agudo en el nivel primario de atención. Desarrollo: se hace especial énfasis en los elementos diagnósticos y la conducta recomendada ajustada a las posibilidades del nivel primario de atención. Conclusiones: el Infarto miocárdico agudo aporta la mayor mortalidad dentro de las enfermedades cardiacas, de causa multifactorial, su diagnóstico en la atención primaria de salud se basa en el cuadro clínico y cambios electrocardiográficos. La trombólisis es piedra angular en el tratamiento temprano de reperfusión.

  19. Infarto agudo do miocárdio na 31ª semana de gravidez: relato de caso

    Directory of Open Access Journals (Sweden)

    Filipa Pires Duarte

    2011-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A ocorrência de infarto agudo do miocárdio (IAM durante a gravidez é rara. Os autores descrevem o caso de IAM numa grávida de 31 semanas e a importância da existência de uma equipe multidisciplinar para sua abordagem. RELATO DO CASO: Grávida de 31 semanas, com antecedentes de tabagismo, alcoolismo e hipertensão, internada após um episódio de síncope. Na admissão, encontrava-se consciente e assintomática, embora hipotensa. O eletrocardiograma evidenciou marcada elevação do segmento ST em DI, AVL, V1-V6. Pesquisa de enzimas cardíacas foi positiva. O ecocardiograma transtorácico demonstrou redução da contratilidade ventricular esquerda e septal e uma fração de ejeção de 30%. A angiografia revelou oclusão proximal da artéria descendente anterior. Por insucesso da angioplastia por balão, foi colocado um stent metálico. A paciente iniciou terapêutica com b-bloqueadores, aspirina e clopidogrel. Em relação ao parto, optou-se por realizar cesariana eletiva, quatro semanas após o IAM. Suspendeu-se o clopidogrel sete dias antes do parto. A função cardíaca pré-operatória foi otimizada com infusão de levosimendana iniciada no dia anterior. A cesariana decorreu sob bloqueio peridural. O período intraoperatório decorreu sem complicações, à exceção de moderada hipotensão facilmente corrigida com fenilefrina. O índice de Apgar do recém-nascido foi de 9/10. CONCLUSÕES: Este é um dos poucos casos de infarto agudo do miocárdio e angioplastia descritos durante a gravidez. Os autores discutem as decisões tomadas pela equipe multidisciplinar, constituída por anestesiologistas, obstetras, cardiologistas e neonatologistas, notadamente no que se refere à dupla antiagregação plaquetária, ao tipo de parto e à anestesia.

  20. Manejo do paciente com infarto agudo do miocárdio atendido no SUS

    Directory of Open Access Journals (Sweden)

    Emerson de Albuquerque Seixas

    2016-10-01

    Full Text Available Introdução: O Infarto Agudo do Miocárdio (IAM é causado pela interrupção do fluxo sanguíneo nas artérias coronárias que irrigam o miocárdio. Trata-se de um evento com alta prevalência, que necessita de internação hospitalar e rápido tratamento. Objetivos: Descrever um caso de IAM que recebeu terapia trombolítica incompleta e realizou angioplastia parcial; Metodologia: Relato de caso de paciente internado no Conjunto Hospitalar de Sorocaba; Relato de Caso: SSA, 74anos, masculino, hipertenso e diabético há 20 anos, procurou o Pronto-Socorro na origem no dia 01/09/2015 com quadro de dor precordial intensa, após realização de esforço físico. Ao exame físico, apresentava-se taquicárdico (FC:150bpm e hipertenso (PA:230X120mmHg.Foi realizado ECG, que evidenciou supradesnivelamento do segmento ST em parede anterior extensa (de V1 a V5,DI e aVL. Foi optado pelo tratamento com agente trombolítico, porém o local só dispunha de metade da dose recomendada. Então foi transferido para o Conjunto Hospitalar de Sorocaba, onde foi optado por não realizar o restante da medicação. Cateterismo cardíaco realizado somente 14 dias depois, evidenciando 4 lesões. Realizada uma angioplastia com implante de apenas 2 stents. Foi solicitado nova angioplastia, que foi negada. Recebeu alta e atualmente aguarda a liberação do procedimento via ambulatorial, com quadro de angina estável. Conclusões: O relato reforça a necessidade da melhoria das condições de atendimento e tratamento de pacientes vítimas de infarto agudo do miocárdio no SUS.

  1. Sindrome confusional agudo por abstinencia aguda de nicotina Delirium due to acute nicotine withdrawal

    Directory of Open Access Journals (Sweden)

    Manuel Klein

    2002-08-01

    Full Text Available El síndrome confusional agudo (SCA o delirium en pacientes hospitalizados es un problema frecuente y grave. Se caracteriza por síntomas de comienzo agudo y curso fluctuante con inatención, pensamiento desorganizado, y con distintos niveles de alteración de la conciencia.En la bibliografía consultada, el SCA como manifestación de un síndrome de abstinencia aguda nicotínica fue descripto en solo ocho casos. Presentamos el caso de un tabaquista grave que, internado por una reagudización de su enfermedad pulmonar obstructiva crónica (EPOC, presentó un cuadro de SCA al tercer día de abstinencia tabacal, cediendo los síntomas tras la administración de un parche de nicotina. Lo descripto sugiere que en pacientes internados que presentan SCA y agitación, con fuertes antecedentes de tabaquismo, un simple ensayo con un parche de nicotina puede ofrecer en pocas horas una notable respuesta terapéutica y a su vez un test confirmatorio. El reconocimiento del SCA como forma de presentación de la abstinencia nicotínica permitirá identificar casos habitualmente complejos en los que se podrá implementar una sencilla y eficaz alternativa terapéutica.Delirium or acute confusional state among hospitalized patients is a frequent and serious problem. It is characterized by acute onset symptoms, fluctuating course, impaired attention, unorganized thinking, and altered level of conciousness. Delirium, as a manifestation of acute nicotine withdrawal syndrome has been reported in the reviewed literature only in eight cases. We report the case of a heavy smoker admitted because of a reagudization of his chronic obstructive pulmonary disease. At the third day of nicotine abstinence, he developed delirium with a rapid improvement of his symptoms after treatment with a transdermal nicotine patch. This description suggests that in hospitalized heavy smokers who develop delirium with agitation, a simple trial with a nicotine patch can offer a dramatic

  2. Current perspectives of acute pain treatment Perspectivas actuales de tratamiento del paciente con dolor agudo

    Directory of Open Access Journals (Sweden)

    Tiberio Alvarez Echeverri

    1993-03-01

    Full Text Available

    In the last years opioids have become of great importance in the relief of postoperative and other forms of acute pain. Reasons for this trend have been the availability of agonist opioids like phentanyl. sulphentanyl and alphentanyl and the results of research on the physlology. The pharmacology and the chemistry of drug receptors and neurotransmitters. The studies on chemicals other than opioids that contribute to pain relief when administered through different ways. specially the spinal. Have also influenced such a trend.

    En los últimos años los opiáceos han adquirido gran importancia en el alivio del dolor agudo especialmente del tipo postoperatorio. Una de las razones ha sido la disponibilidad de morfínicos agonistas como el fentanil, el sufentanil y el alfentanil; otra es la investigación de la fisiología, la farmacología y la química de los receptores y los neurotransmisores como de sustancias diferentes a los opláceos, aplicadas por diferentes vías en especial la espinal, que coadyuvan al alivio del dolor.

  3. RELACIONES FAMILIARES EN LA ADOLESCENCIA. Estudio piloto sobre la aceptación / rechazo parental en función del sexo y la edad en una muestra de adolescentes extremeños.

    OpenAIRE

    Martín-López, Eva

    2012-01-01

    Este trabajo se enmarca dentro de una investigación más amplia relacionada con la convivencia escolar y bullying en centros de Educación Primaria y Secundaria de la Comunidad Autónoma de Extremadura y pretende evaluar la percepción de los hijos acerca de los estilos educativos parentales, en concreto la aceptación/rechazo parental para obtener así información sobre variables moduladoras como son el sexo y la edad en una muestra de 700 adolescentes, estudiantes de Educación Secundaria Obligato...

  4. Construcción y explotación de una planta piloto de electrodiálisis para concentración de salmuera de rechazo de desalación

    OpenAIRE

    Lourenço Luis, Sérgio Miguel

    2009-01-01

    Actualmente, la escasez de agua para consumo humano generó una búsqueda por novas tecnologías que permitan satisfacer las necesidades humanas. Las tecnologías de desalinización presentan una solución, el agua de mar es un bien abundante en nuestro planeta, así que la desalinización es una plus valía, entre muchas otras tecnologías de desalinización encontramos la osmosis inversa, esta es ampliamente usada, sin embrago esta genera un rechazo o vertido que tiene que ser tratado. Entonces surge ...

  5. Frecuencia de secuela renal pos evento agudo en síndrome urémico hemolítico

    Directory of Open Access Journals (Sweden)

    Jose Antonio Lulli-Cantoni

    2015-04-01

    Full Text Available Objetivos: Determinar la frecuencia de secuela renal después del evento agudo de Síndrome Urémico Hemolítico (SUH en niños y los factores asociados a la presencia de secuelas. Material y métodos: Estudio descriptivo y retrospectivo. Se revisaron las historias clínicas de los pacientes con SUH en el HNCH de 1997 al 2012, y se registraron datos de características clínicas, hallazgos de laboratorio y parámetros de función renal al ingreso, al alta y a los seis meses después del alta. En los casos que no contaban con control a los 6 meses, se intentó contactar a los pacientes para tomar nuevos controles. Resultados: Siete de 12 pacientes presentaron disminución en la tasa de filtración glomerular (TFG o proteinuria o hipertensión a los 6 meses o más después del episodio agudo, con un promedio de 30,75 meses de seguimiento. Tanto en los pacientes con secuelas como con recuperación renal se encontró una distribución similar de los factores asociados a secuelas como hipertensión al alta, proteinuria al alta, necesidad de diálisis, oligoanuria, leucocitosis > 20 000 cel/mm3 y síntomas neurológicos. Sin embargo algunas variables como oligoanuria y necesidad de diálisis se encontraron a niveles por debajo de los descritos en la literatura. Conclusiones: Es claro que existen pacientes con secuelas renales luego del episodio agudo de SUH que además presentan varios factores predictores de secuelas descritos en la literatura.

  6. Grupos de utilizacion de recursos en unidades de agudos y media estancia de servicios de geriatria

    Directory of Open Access Journals (Sweden)

    Solano Jaurrieta Juan José

    2001-01-01

    Full Text Available Fundamentos: En los últimos años se han implantado en nuestro país Sistemas de Clasificación de Pacientes (SCP con objeto de medir el «producto hospitalario». Sin embargo los sistemas más tradicionales resultan poco adecuados para la población anciana, en los que la incapacidad asociada a la enfermedad resulta determinante para explicar el consumo de recursos y los resultados asistenciales. Por ello, nos planteamos aplicar en servicios especializados de atención al anciano un sistema que contempla este parámetro, los Grupos de Utilización de Recursos (RUG, analizando las características y diferencias en la distribución en función de RUG en cuatro Servicios de Geriatría. Métodos: Se estudian transversalmente, mediante cortes sucesivos en períodos superiores a la estancia media en cada unidad, los pacientes ingresados en las unidades de agudos y media estancia de los Servicios de Geriatría del Hospital Monte Naranco (HMN (n=318, Hospital Central de la Cruz Roja (HCCR (n=384, Hospital General de Guadalajara (HG (n=272 y Hospital Virgen del Valle (HVV (n=390, en lo relativo a su distribución según la clasificación RUG-T18. Las posibles diferencias entre los centros se analizaron mediante el test estadístico chi-cuadrado (SPSS para windows Resultados: Para el conjunto de la muestra los pacientes se concentran en los grupos R, S y C de la clasificación, con muy escasa representación de los grupos P y B, detectándose diferencias entre los centros. Así, el HCCR es el que maneja una mayor proporción de pacientes del grupo R (47,64% vs. 23,66% en el HMN, 20,57% en el HG y 20,53% en el HVV y una menor proporción de pacientes del grupo S (3,12% vs 6,40% en el HMN, 9,92% en el HG y 9,76% en el HVV y C (48,94% vs 76,29% en el HMN, 66,89% en el HG y 68,36% en el HVV. Igualmente es posible detectar diferencias en el análisis individual para las unidades de agudos y media estancia. Conclusiones: Los grupos de utilización de recursos

  7. GRUPOS DE UTILIZACION DE RECURSOS EN UNIDADES DE AGUDOS Y MEDIA ESTANCIA DE SERVICIOS DE GERIATRIA

    Directory of Open Access Journals (Sweden)

    Juan José Solano Jaurrieta

    2001-01-01

    Full Text Available Fundamentos: En los últimos años se han implantado en nuestro país Sistemas de Clasificación de Pacientes (SCP con objeto de medir el «producto hospitalario». Sin embargo los sistemas más tradicionales resultan poco adecuados para la población anciana, en los que la incapacidad asociada a la enfermedad resulta determinante para explicar el consumo de recursos y los resultados asistenciales. Por ello, nos planteamos aplicar en servicios especializados de atención al anciano un sistema que contempla este parámetro, los Grupos de Utilización de Recursos (RUG, analizando las características y diferencias en la distribución en función de RUG en cuatro Servicios de Geriatría. Métodos: Se estudian transversalmente, mediante cortes sucesivos en períodos superiores a la estancia media en cada unidad, los pacientes ingresados en las unidades de agudos y media estancia de los Servicios de Geriatría del Hospital Monte Naranco (HMN (n=318, Hospital Central de la Cruz Roja (HCCR (n=384, Hospital General de Guadalajara (HG (n=272 y Hospital Virgen del Valle (HVV (n=390, en lo relativo a su distribución según la clasificación RUG-T18. Las posibles diferencias entre los centros se analizaron mediante el test estadístico chi-cuadrado (SPSS para windows Resultados: Para el conjunto de la muestra los pacientes se concentran en los grupos R, S y C de la clasificación, con muy escasa representación de los grupos P y B, detectándose diferencias entre los centros. Así, el HCCR es el que maneja una mayor proporción de pacientes del grupo R (47,64% vs. 23,66% en el HMN, 20,57% en el HG y 20,53% en el HVV y una menor proporción de pacientes del grupo S (3,12% vs 6,40% en el HMN, 9,92% en el HG y 9,76% en el HVV y C (48,94% vs 76,29% en el HMN, 66,89% en el HG y 68,36% en el HVV. Igualmente es posible detectar diferencias en el análisis individual para las unidades de agudos y media estancia. Conclusiones: Los grupos de utilización de recursos

  8. Morbilidad y mortalidad en pacientes con infarto agudo de miocardio ST elevado en un hospital general

    Directory of Open Access Journals (Sweden)

    Eduardo Carcausto

    2010-10-01

    Full Text Available Objetivo: Determinar la morbilidad y mortalidad de los pacientes con infarto agudo de miocardio ST elevado (IMA STE atendidos en un hospital general y describir sus características demográficas, clínicas y epidemiológicas. Material y métodos: Estudio descriptivo, serie de casos, retrospectivo, en pacientes con IMA STE en el Hospital Nacional Cayetano Heredia, del 1 de enero a 31 de diciembre del 2007. Se registraron variables clínicas y de laboratorio. Resultados: Se incluyeron 30 casos. El 86,7% fueron varones. La edad media fue de 62,8±12,6 años. El antecedente de hipertensión arterial se encontró en 57%, obesidad en 40%, tabaquismo en 40%, y de diabetes mellitus en 30%. El dolor torácico típico ocurrió en 75% de pacientes. El 50% de pacientes tuvieron hipertensión no controlada a la admisión, 33% leucocitosis, y 46% glicemia >110 mg/dl. Sólo 25% recibió terapia de reperfusión, 33,3% de casos de forma exitosa, siendo el tiempo puerta-aguja de 250 ± 114 minutos. Las complicaciones ocurrieron en 26,6% de pacientes, siendo la mortalidad de 13,3%. El 76% ingresó al hospital con un tiempo de dolor menor de 3 horas, Conclusiones: Los pacientes con IMA ST elevado fueron predominantemente varones, mayores de 60 años, ingresaron al hospital con un tiempo de dolor torácico menor de tres horas y un mínimo porcentaje recibió terapia de repercusión. Las arritmias fueron las complicaciones más frecuentes y la mortalidad post IMA alcanzó 13,3 % de los casos.(Rev Med Hered 2010;21:202-207.

  9. Adherencia al tratamiento y calidad de vida en personas con infarto agudo de miocardio

    Directory of Open Access Journals (Sweden)

    Jennifer Rojas-Reyes

    2016-01-01

    Full Text Available Objetivo: identificar la asociación entre adherencia al tratamiento y calidad de vida relacionada con la salud (CVRS en población con infarto agudo de miocardio (IAM. Materiales y método: estudio cuantitativo de diseño descriptivo correlacional de corte transversal. Se eligieron 180 participantes por muestreo de tipo probabilístico con selección aleatoria simple. Para el análisis estadístico, se utilizó estadística no paramétrica con correlación de Spearman. Resultados: la edad media fue de 63 años, el promedio de tiempo transcurrido después del infarto fue de 35 meses. Frente al nivel de adherencia al tratamiento, predominó la adherencia total (54 %, adherencia parcial (45%; en cuanto a la calidad de vida relacionada con la salud, el 27 % tuvo un bajo nivel; respecto a la correlación de Spearman, se estableció un coeficiente de -0,315 con una significancia de p=0,00, donde el número negativo es reflejo de la naturaleza de las escalas con las que fueron medidas las variables, por lo que la correlación es positiva, significativa, pero numéricamente modesta. Conclusión: la asociación entre adherencia al tratamiento y calidad de vida relacionada con la salud evidencia en una correlación estadísticamente significativa, pero catalogada como modesta, siendo estos resultados coherentes con la multidimensionalidad de los fenómenos.

  10. Terapia trombolítica en pacientes con infarto agudo de miocardio en Cienfuegos

    Directory of Open Access Journals (Sweden)

    Lázaro Abilio Hernández Rodríguez

    2014-03-01

    Full Text Available Fundamento: el tratamiento trombolítico practicado a menos de dos horas, tras el inicio del infarto tiene resultados similares a la reperfusión mecánica. Objetivo: describir aspectos relevantes de la terapia trombolítica en pacientes con infarto agudo de miocardio con elevación del segmento ST en Cienfuegos. Métodos: estudio descriptivo, prospectivo, en 225 pacientes egresados (vivos y fallecidos desde el 1o de abril de 2012 al 31 marzo de 2013, de la Unidad de Cuidados Integrales del Corazón y la Unidad de Cuidados Intensivos Polivalentes, del Hospital Dr. Gustavo Aldereguía Lima. Las variables estudiadas se obtuvieron de la revisión de las historias clínicas e incluyeron: variables demográficas y clínicas, tiempos de demora, sitio, motivo de exclusión y nivel de prioridad para la trombolisis. Resultados: la media de edad superó los 60 años. Predominaron los hombres, hipertensos y de alto riesgo según la escala GRACE. El 29,7 % de los pacientes no recibió terapia trombolítica, debido mayormente al factor tiempo y la mayoría (82,3 % se trató en el Hospital. Las medianas de los tiempos de demora: síntomas-puerta, puerta-droga y síntomas-droga fueron 90, 35 y 140 minutos respectivamente. Conclusiones: la trombolisis extrahospitalaria acorta el tiempo total de isquemia, pero pocos pacientes se beneficiaron de ella. Los retrasos para la terapia trombolítica en Cienfuegos continúan por encima de los estándares requeridos.

  11. Radicales libres de oxígeno y distress respiratorio agudo

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    Aracelis E. Dorado Lambert

    2000-09-01

    Full Text Available Se realizó una revisión acerca de la formación de radicales libres de oxígeno en el organismo, así como el aumento exagerado de su génesis durante la exposición a altas concentraciones de oxígeno y en el desarrollo de la explosión respiratoria que acompaña la fagocitosis. Se analiza además la formación de estos radicales en el pulmón durante la evolución del distress respiratorio agudo. Se abordó, posteriormente, el uso actual, sobre todo en el ámbito internacional, de los antioxidantes y bloqueadores de la lipoperoxidación para disminuir los efectos adversos de los radicales libres. A pesar de estas nuevas medidas, se corrobora que la disminución experimentada en la mortalidad por esta entidad, obedece a la optimización de los cuidados respiratorios, en especial la ventilación mecánica.The formation of free oxygen radicals in the body and the excessive increase of its genesis during exposure to high concentrations of oxygen and in the development of respiratory burst accompanying phagocytosis were reviewed. Also the formation of these radicals in lung during acute respiratory distress was analyzed. Similarly, the present use at the international level of antioxidants and lipoperoxidation blockers to diminish adverse effects of free radicals are addressed in this paper. In spite of these new measures, it was confirmed that the reduction of mortality rate from this disease was due to the improvement of respiratory care particularly the mechanical ventilation.

  12. Daño pulmonar agudo asociada a transfusión en el embarazo

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    Silvia María Melians Abreu

    2014-06-01

    Full Text Available Introducción: el daño pulmonar agudo asociado a la transfusión es una reacción adversa a la transfusión poco frecuente, la mortalidad se ha estimado entre 1-10 %. Su diagnóstico es clínico e infrecuentemente sospechado, su incidencia es baja. Presentación del caso: se presentaron dos transfusión-related-acute-lunginjury en dos gestantes con 28,5 y 32 semanas de embarazo respectivamente, hospitalizadas en la salas de cuidados materno perinatales con enfermedades asociadas al embarazo, a quienes se le administraron componentes sanguíneos, ambas a las 5 horas de transfundidas; presentaron el síndrome clínico con hipoxemia moderada y necesitaron ventilación; con estos hallazgos y la relación temporal con la transfusión. Se realizó el diagnóstico de síndrome de dificultad respiratoria aguda moderada asociada a transfusión. Conclusiones: el resultado fue óptimo con resolución completa del evento respiratorio. Se considera importante reportar ambos casos dado su aparición en embarazadas, causa poco frecuente informada en la literatura y la importancia de conservar la salud de la madre del niño y la niña e incentivar la notificación de esta reacción adversa a la transfusión al banco de sangre para fortalecer el sistema de hemovigilancia.

  13. Nefropatía por contraste en el síndrome coronario agudo

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    Mariana Carnevalini

    2011-10-01

    Full Text Available La nefropatía inducida por contraste (NIC es una de las causas más frecuentes de insuficiencia renal en pacientes internados. En el síndrome coronario agudo (SCA, la presencia de NIC aumenta la morbimortalidad. Las medidas de profilaxis y los factores de riesgo intervinientes de NIC en SCA no han sido determinados con exactitud. El objetivo de este estudio fue evaluar la incidencia de NIC y los factores asociados a su desarrollo en pacientes ingresados en unidad coronaria con requerimiento de cinecoronariografía (CCG. Se realizó un estudio de cohorte retrospectivo. Se incluyeron pacientes consecutivos cursando SCA estudiados con CCG dentro de las 72 horas de su admisión. Se definió NIC al aumento del 25% del valor de creatinina a las 48 h sobre el nivel basal de ingreso. El período de inclusión fue entre el 1° de enero de 2004 hasta el 30 de junio de 2010. Se analizaron 125 casos. La incidencia de NIC fue del 10.4% (n = 13. En el análisis multivariado, los factores asociados independientemente a su desarrollo fueron la edad [OR 1.05 (IC 95% 1.004 - 1.11 p = 0.034], la angioplastia a múltiple vaso [OR 2.2 (IC 95% 1.07 - 4.8, p = 0.03] y el volumen de contraste utilizado [OR 1.007 (IC 95% 1.001 - 1.01, p = 0.014].

  14. Descripción de un brote de enfisema y edema pulmonar agudo del bovino (EPAB) en Parral (Chile)

    OpenAIRE

    URRUTIA, H.; BREVIS, C.; QUEZADA, M.; DONOSO, S.

    1997-01-01

    Se describe un brote de enfisema y edema alveolar agudo del bovino (EPAB) ocurrido en la zona centro-sur a fines del verano de 1995. Los animales Frisón negro, de aproximadamente 2 años de edad, fueron afectados después de cambiarse de una pradera fibrosa a una suculenta de alfalfa. La mortalidad por esta causa fue de un 23%. Las principales lesiones encontradas en la necropsia fueron enfisema y edema intersticial intenso del pulmón, lo cual fue corroborado histopatológicamente, encontrándos...

  15. Fisiopatología del dolor agudo: alteraciones cardiovasculares, respiratorias y de otros sistemas y órganos

    OpenAIRE

    Pérez-Castañeda Jorge, Tania

    2012-01-01

    Introducción: El dolor agudo constituye una compleja constelación de experiencias sensoriales y emocionales, relacionadas con respuestas autónomas producidas por daño a estructuras somáticas o viscerales. Las vías del dolor transmiten la información nociceptiva a través del sistema nervioso periférico y central y están plenamente integradas con el sistema motor y simpático a nivel medular y de los centros nerviosos superiores y dan lugar a actividad motora refleja, hiperactividad simpática y ...

  16. Descripción de un brote de enfisema y edema pulmonar agudo del bovino (EPAB) en Parral (Chile)

    OpenAIRE

    H. URRUTIA; C. BREVIS; M. QUEZADA; S. DONOSO

    1997-01-01

    Se describe un brote de enfisema y edema alveolar agudo del bovino (EPAB) ocurrido en la zona centro-sur a fines del verano de 1995. Los animales Frisón negro, de aproximadamente 2 años de edad, fueron afectados después de cambiarse de una pradera fibrosa a una suculenta de alfalfa. La mortalidad por esta causa fue de un 23%. Las principales lesiones encontradas en la necropsia fueron enfisema y edema intersticial intenso del pulmón, lo cual fue corroborado histopatológicamente, encontrándose...

  17. Sistema informático para la gestión de la información hospitalaria del infarto agudo de miocardio (RHIMA)

    OpenAIRE

    Yanier Coll Muñoz; Francisco Valladares Carvajal; Jorge L. Fernández Curbelo; Ing. Luis E. Fernández Curbelo

    2015-01-01

    Introducción: La difícil recopilación de información sobre la prevalencia y desarrollo del infarto agudo de miocardio imposibilita medir la calidad del tratamiento durante la evolución de la enfermedad en un determinado grupo de pacientes.Objetivo: Desarrollar un sistema informático que permita la gestión de la información hospitalaria del infarto agudo de miocardio en el Servicio de Cardiología.Método: Se identificaron las variables necesarias para la confección del registro, divididas por b...

  18. Características clínicas y diagnósticas en infarto renal agudo en una serie clínica

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    C. Juan Alberto Fierro, Dr.

    2010-07-01

    Full Text Available El infarto renal agudo constituye un diagnóstico infrecuente. Ello puede deberse a que sus síntomas son similares a los de los cálculos renales o la pielonefritis aguda. Por esa razón, el síntoma cardinal de dolor de flanco debe ser investigado en forma muy acabada. Esta serie clínica revisa seis casos de infarto renal agudo vistos en esta institución durante el año 2007.

  19. Occurrence of uranium in the itabiritic iron ore of Morro Agudo on the NE border of the iron Quadrangle/Minas Gerais, Brasilien

    International Nuclear Information System (INIS)

    Guba, I.

    1982-01-01

    The precambrian itabirites and hematite ores of the Morro Agudo iron ore mine on the NE border of the Quadrilatero Ferrifero in Minas Gerais/Brazil contain uranium-bearing minerals and rare-earth elements. In association with phosphates they occupy planes of joints, fractures and cleavage in the area of amphibolitic schist which is intercalated in the s 1 -planes of the itabirites and hematite ores. Preliminary analyses of the uranium-bearing minerals were made by energy dispersive X-ray spectrometry and electron microscopy. The results are presented in connection with the lithologic and tectonic features of the Morro Agudo mine. (orig.) [de

  20. Bioprinting for vascular and vascularized tissue biofabrication.

    Science.gov (United States)

    Datta, Pallab; Ayan, Bugra; Ozbolat, Ibrahim T

    2017-03-15

    Bioprinting is a promising technology to fabricate design-specific tissue constructs due to its ability to create complex, heterocellular structures with anatomical precision. Bioprinting enables the deposition of various biologics including growth factors, cells, genes, neo-tissues and extra-cellular matrix-like hydrogels. Benefits of bioprinting have started to make a mark in the fields of tissue engineering, regenerative medicine and pharmaceutics. Specifically, in the field of tissue engineering, the creation of vascularized tissue constructs has remained a principal challenge till date. However, given the myriad advantages over other biofabrication methods, it becomes organic to expect that bioprinting can provide a viable solution for the vascularization problem, and facilitate the clinical translation of tissue engineered constructs. This article provides a comprehensive account of bioprinting of vascular and vascularized tissue constructs. The review is structured as introducing the scope of bioprinting in tissue engineering applications, key vascular anatomical features and then a thorough coverage of 3D bioprinting using extrusion-, droplet- and laser-based bioprinting for fabrication of vascular tissue constructs. The review then provides the reader with the use of bioprinting for obtaining thick vascularized tissues using sacrificial bioink materials. Current challenges are discussed, a comparative evaluation of different bioprinting modalities is presented and future prospects are provided to the reader. Biofabrication of living tissues and organs at the clinically-relevant volumes vitally depends on the integration of vascular network. Despite the great progress in traditional biofabrication approaches, building perfusable hierarchical vascular network is a major challenge. Bioprinting is an emerging technology to fabricate design-specific tissue constructs due to its ability to create complex, heterocellular structures with anatomical precision

  1. Alimentación de bovinos con ensilado de mezclas de banano de rechazo y ráquis en diferentes proporciones

    Directory of Open Access Journals (Sweden)

    J. C. De la Cruz-Hernández

    2006-01-01

    Full Text Available Con el propósito de evaluar el comportamiento productivo de bovinos consumiendo ensilado de mezclas de banano de rechazo como fruta y ráquis en diferentes proporciones, se realizó una prueba de alimentación con 12 bovinos cebú comercial, machos, enteros, con un peso promedio de 168±17 kg, a los que se les asignó, de manera aleatoria, cada uno de los siguientes tratamientos: I ensilado con 50% banano y 50% ráquis; II ensilado con 75% banano y 25% ráquis; y III un grupo testigo con zacate Taiwán (Pennisetum purpureum. Los animales recibieron, además, 1.1 kg de pasta de soya como fuente proteica y 50 g de una premezcla comercial de minerales y sal común. La prueba tuvo una duración de 120 días, más un tiempo de adaptación de 15, periodo en el que las dietas se ofrecieron a libertad. Los animales fueron pesados cada 30 días y se les llevó diariamente el control de consumo de alimento. Las mejores (P0.05 entre ellos. El consumo de alimento base húmeda (CABH no presentó diferencias significativas (P>0.05 entre tratamientos; sin embargo, el consumo de alimento base seca (CABS fue mayor (P<0.05 en el tratamiento ensilado de banano-ráquis 75:25 comparado con el de 50:50 (6.433 vs. 4.308 kg. El consumo de materia seca/100 kg de peso vivo fue mayor (P<0.05 para los animales que consumieron zacate Taiwán y ensilado de banano-ráquis 75:25 (2.334 y 1.990, comparados con los del ensilado 50:50 (1.413. El consumo de proteína cruda en kg fue mayor (P<0.05 para los animales alimentados con zacate Taiwán. Porcentualmente, el consumo de proteína cruda fue mayor (P<0.05 en los animales que consumieron zacate Taiwán y ensilado de banano-ráquis 50:50 (16.99 y 17.36 %. La mayor eficiencia alimenticia (P<0.05 la obtuvieron los animales que consumieron el ensilado de banano-ráquis 50:50. El análisis económico de este sistema de alimentación nos indica que se obtuvieron las mayores ganancias con el uso de los ensilados, siendo el mejor

  2. Caracterización del infarto agudo del miocardio en mujeres atendidas en el hospital Ernesto Guevara

    Directory of Open Access Journals (Sweden)

    Zailit González Cruz

    2014-08-01

    Full Text Available En Las Tunas han aumentado las cifras de mujeres afectadas por infarto agudo del miocardio (IMA, con una tasa de mortalidad superior a la media nacional. A pesar de ello, no existen estudios publicados que describan el comportamiento de esta entidad en las mujeres tuneras. Se realizó un estudio transversal descriptivo en el servicio de cardiología del hospital provincial de Las Tunas, “Dr. Ernesto Guevara de la Serna”, entre los años 2009 al 2011, con el objetivo de caracterizar el infarto agudo del miocardio en el sexo femenino. La muestra estuvo constituida por 181 mujeres admitidas en el servicio por esta entidad, diagnosticadas según los criterios establecidos. Para el análisis de los resultados se utilizó la estadística descriptiva, con valores absolutos y porcientos. En la muestra de estudio prevaleció el IMA CEST, de topografía anterior y no trombolizado. La disfunción ventricular izquierda constituyó la complicación más frecuente. Predominaron como factores de riesgo asociados la hipertensión arterial, las dislipidemias, el hábito de fumar y la diabetes mellitus.

  3. COMPARTIMENTAÇÃO DE UNIDADES GEOMORFOLÓGICAS DO MUNICÍPIO DE AGUDO-RS

    Directory of Open Access Journals (Sweden)

    Gerson Jonas Schirmer

    2013-12-01

    Full Text Available Este artigo apresenta um mapeamento geomorfológico do município de Agudo-RS, onde as unidades geomorfológicas representam a integração dos elementos físicos da área de estudo, frente aos processos envolvidos na organização da paisagem local. A metodologia é fundamentada nas contribuições da ciência geográfica, utilizando como ferramenta SIGs (Sistemas de Informação Geográfica.  Através de uma representação de síntese, foram definidos cinco unidades geomorfológicas, Rampas deColúvio-Aluvio do Rio Jacuí, Rampas de Colúvio-Alúvio de Arroios, Colinas Alúvio-Coluvionar, Colinas Vulcânicas do Planalto Serra Geral e Associação de Morros e Morrotes do Rebordo do Planalto, que caracterizam a paisagem do município de Agudo.

  4. Fisiopatología, evaluación y manejo del dolor agudo en pediatría

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    Tatiana Pabón-Henao

    2015-12-01

    Full Text Available El manejo del dolor agudo en los niños es deficiente, como lo afirma en el 2013 un estudio de la AMA (American Medical Association: la población pediátrica recibe entre 50% y 90% menos analgésicos que los adultos, es decir, no se tiene claridad en la fisiopatología, abordaje y manejo del dolor en los niños. El dolor puede clasificarse según su tiempo de duración, intensidad y mecanismo fisiopatoló-gico que lo desencadena (nociceptivo y neuropático. Teniendo en cuenta que la fisiopatología del dolor no varía con la edad pero sí como el paciente pediátrico lo manifieste, se requiere conocer el abordaje y manejo según su intensidad. Por lo tanto, el objetivo de esta revisión se enfoca en el estado del arte y en generar claridad de los aspectos críticos como son el conocimiento de la fisiopatología, valoración adecuada y el manejo no farmacológico y farmacológico del dolor agudo en pediatría.

  5. Mapping of micro and Small branch of industrial enterprises located in the cities of Agudo and Silveira Martins – RS

    Directory of Open Access Journals (Sweden)

    Carla Hartmann Sturm

    2016-06-01

    Full Text Available In the development of a country are the companies responsible for creating jobs, pay taxes and thus cause the economic and regional development. In Brazil, most of these institutions is made up of micro enterprises and small that often struggling to survive in the market. Therefore, it is necessary investments and public incentives to encourage their development making them competitive. In this sense, this article aims to develop a mapping of micro and small enterprises in the industrial sector in the cities of Agudo and Silveira Martins – Rio Grande do Sul (RS. For this, we used a descriptive research on the purposes and literature as to the means being prepared a questionnaire for collecting data from the sample studied. As results obtained ten micro companies and three small businesses were found in Agudo – RS, and the main industries are the timber industry and the manufacture of bakery products, influenced 65.5% of the employees of micro and small companies analyzed in the municipality. Already in Silveira Martins – RS were found seven micro and small enterprises, where six are classified as micro company and only one as small business. It was found also that the main industrial branch is the timber sector (six companies, in which 96% of employees work in any activity related to wood processing.

  6. Traumatismos vasculares revisão de 5 anos Vascular Trauma a five year review

    Directory of Open Access Journals (Sweden)

    Luís F. Antunes

    2011-06-01

    Full Text Available O presente trabalho pretende avaliar a casuística dos traumatismos vasculares agudos admitidos no Serviço de Cirurgia Vascular dos Hospitais da Universidade de Coimbra (HUC durante o período de 5 anos, compreendido entre Julho de 2004 e Junho de 2009. Foram avaliados 97 doentes, sendo a principal causa de traumatismo as lesões iatrogénicas, seguida dos acidentes de viação. No grupo de doentes não relacionados com procedimentos coronários percutâneos verificou-se que no membro superior as artérias umeral e radial foram as mais afectadas, enquanto no membro inferior foram as artérias femoral superficial e poplítea. A isquémia aguda foi a principal forma de apresentação. Relativamente ao tratamento deste grupo de doentes, a RATT (ressecção e anastomose topo-topo e o enxerto foram os mais utlizados no membro superior, enquanto a trombectomia e o bypass foram as técnicas mais aplicadas a nível do membro inferior. Não houve mortalidade mas a morbilidade foi elevada, predominando as lesões neurológicas nos traumatismos do membro superior, e a amputação nos do membro inferior. Os resultados deste trabalho foram concordantes com o que está publicado na literatura em que se demonstra um aumento progressivo dos traumatismos de origem iatrogénica.This review intended to evaluate the series of acute vascular trauma in the Vascular Surgery Service of the Coimbra University Hospital in the period between July 2004 and June 2009. A total of 97 patients were evaluated with iatrogenic lesions being the main cause of trauma injuries, followed by traffic accidents. In group of patients not related with percutaneous coronary angioplasty, it was found that brachial and radial arteries were the most affected in upper limb, while in the lower limb were the superficial femoral and popliteal arteries. The main clinical manifestation was acute ischemic limb. In this group, resection with end-to-end anastomosis and grafts were the main treatment

  7. Sobrecarga en el cuidador de paciente con infarto agudo al miocardio

    Directory of Open Access Journals (Sweden)

    Norma Lizbeth Ávila Estrada

    2012-12-01

    Full Text Available Introducción: Las enfermedades cardiovasculares constituyen la primera causa de muerte en México, generando un impacto social persistente que involucra tanto a quien lo padece como a quienes lo rodean. Objetivo: Determinar el nivel de sobrecarga en el cuidador con pacientes de infarto agudo miocardio (IAM en el Hospital General de Durango. Materiales y Métodos: Estudio descriptivo no experimental, transversal; 54 familiares de pacientes hospitalizados con diagnóstico de IAM en el Hospital General Durango, no probabilístico por conveniencia. Resultados: La edad promedio en el estudio es de 18 a 25 años correspondiendo al 37%, de los cuales el 66.7% es femenino, 59.3% tiene escolaridad de medios superior, el 72.2% son de procedencia de la ciudad de Durango, con respecto al parentesco del cuidador con la persona que demanda cuidado esta es en su mayoría hijo con un porcentaje de 20.4%; también un alto porcentaje 81.5 % convive con el enfermo y un 63.0% trabaja fuera del hogar, y un 27.8% ha dejado el trabajo parcialmente; el resultado revelo que existe un nivel medio de sobrecarga del 44.2% en el cuidador primario. Discusión y Conclusiones: Son identificables los niveles de sobrecarga en cuidadores de pacientes con IAM generando una serie de variables que alteran la relación cuidador-paciente trayendo consigo una sobrecarga de tipo medio. (Rev Cuid 2012;3(3:342-8.Palabras clave: Cuidados Posteriores, Absentismo Familiar, Atención no Remunerada. (Fuente: DeCS BIREME.

  8. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    Science.gov (United States)

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  9. EFECTO AGUDO DEL EJERCICIO FISICO EN LA INTELIGENCIA Y LA MEMORIA EN HOMBRES, SEGUN LA EDAD

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    Yorleny Alfaro Chavarría

    2001-12-01

    Full Text Available Con muy diversas investigaciones se han demostrado los efectos agudos del ejercicio físico en los procesos cognitivos (memoria, inteligencia, tiempo de reacción, creatividad, etc. según la edad. Sin embargo, gran cantidad de variables se ven involucradas en los diferentes tratamientos. Es, por esto, que se pretendió realizar una investigación específica y homogénea, de manera que los cambios obtenidos en la inteligencia y la memoria en las diferentes edades se deban al tratamiento en sí, y no a la influencia de otros factores. Para esto, se aplicó un tratamiento que consistió en realizar ejercicio aeróbico subiendo y bajando una grada de 27 cm. de alto x 30 cm. de ancho, durante 10 minutos, a una intensidad del 60% de la frecuencia cardíaca máxima. Los sujetos fueron 100 hombres con edades entre la niñez y la edad avanzada. Se ubicaron en 5 subgrupos que realizaron un 'pretest', el tratamiento indicado y un 'postest'. Las pruebas fueron el test de Raven para la inteligencia y el Verbal Script Digit Span para medir la memoria auditiva. Para conocer los resultados se realizó un análisis de varianza Anova 5x2x2 para grupos independientes, utilizando los puntajes obtenidos en las diferencias entre 'pretest' y 'postest', para ambas variables, con su respectivo 'post-hoc' en los casos requeridos. Y para determinar la magnitud del cambio, se obtuvo los tamaños del efecto. Se encontró que con ejercicio aeróbico submaximal, la totalidad de los grupos etarios mejoraron sus resultados en el test de memoria con mejor resultado los de edades promedio de 25.5 y 63.25 años. Para la variable de inteligencia los sujetos de 34.75 y 52.4 años en promedio lograron los mejores resultados, mientras que los jóvenes de 25.5 años y los adultos mayores no tuvieron cambio significativo en este aspecto.

  10. Edad avanzada y factores de riesgo para infarto agudo de miocardio

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    M. A. Ciruzzi

    2002-12-01

    Full Text Available Este estudio caso-control analizó en los sujetos añosos el rol de los factores de riesgo coronario en el desarrollo del infarto agudo de miocardio (IAM, estableció la naturaleza de esta asociación y el grado de riesgo. Los datos fueron obtenidos en una investigación que incluyó 1060 casos y 1071 controles, realizada en 35 unidades coronarias de centros médicos de Argentina entre noviembre de 1991 y agosto de 1994. Nuestro análisis se basó en la información de los sujetos mayores de 65 años. Los casos fueron 427 pacientes con un primer IAM. Los controles fueron 396 sujetos sin evidencias clinicas de enfermedad cardiovascular, seleccionados en los mismos centros que los casos. Los Odds Ratios (OR y su intervalo de confianza del 95% (IC 95% se obtuvieron mediante un análisis de regresión logística, incluyendo variables como la edad, educación, clase social, tabaquismo, antecedente de diabetes o hipertensión arterial, índice de masa corporal e historia familiar de enfermedad coronaria. Los factores de riesgo relacionados independientemente con IAM fueron los siguientes: hipercolesterolemia (colesterol sérico > 240 mg/dl: OR=1.76 (IC 95%: 1.25-2.49, tabaquismo: OR=1.6 (IC 95%: 1.06-2.4, hipertensión arterial: OR=2.05 (IC 95%: 1.51-2.73, diabetes OR=1.71 (IC 95%: 1.12-2.70, historia de un familiar con enfermedad coronaria: OR=1.36 (IC 95%: 0.93-1.97 y de dos o más familiares: OR=2.63 (IC 95%: 1.21-5.71. Este estudio, confirma en los sujetos de edad avanzada la importancia de la hipercolesterolemia, del tabaquismo, la hipertesión arterial, la diabetes y la historia familiar de enfermedad coronaria como factores de riesgo de IAM

  11. Decúbito prono en pacientes con síndrome de distrés respiratorio agudo

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    Mariano Setten

    Full Text Available RESUMEN El síndrome de distrés respiratorio agudo ocupa gran atención en la unidad de cuidados intensivos. A pesar del amplio conocimiento alcanzado sobre la fisiopatología de éste síndrome, el enfoque en la unidad de cuidados intensivos consiste, en gran parte, en un tratamiento de soporte vital y en evitar los efectos secundarios de las terapéuticas invasivas. Si bien, durante los últimos 20 años, se generaron grandes avances en ventilación mecánica con un impacto importante sobre la mortalidad, ésta continúa siendo elevada. Una característica de los pacientes con síndrome de distrés respiratorio agudo, sobre todo los más severos, es la presencia de hipoxemia refractaria debido a la existencia de shunt, pudiendo requerir tratamientos adicionales a la ventilación mecánica, entre ellos la ventilación mecánica en decúbito prono. Este método, recomendado para mejorar la oxigenación por primera vez en 1974, puede ser implementado fácilmente en cualquier unidad de cuidados intensivos con personal entrenado. El decúbito prono tiene un sustento bibliográfico sumamente robusto. Varios ensayos clínicos randomizados han demostrado el efecto del decúbito prono sobre la oxigenación en pacientes con síndrome de distrés respiratorio agudo medida a través de la relación PaO2/FiO2 e incluso su impacto en el aumento de la sobrevida de estos pacientes. Los integrantes del Comité de Kinesiología Intensivista de la Sociedad Argentina de Terapia Intensiva realizaron una revisión narrativa con el objetivo de exponer la evidencia disponible en relación a la implementación del decúbito prono, los cambios producidos en el sistema respiratorio por la aplicación de la maniobra y su impacto sobre la mortalidad. Por último, se sugerirán lineamientos para la toma de decisiones.

  12. Diagnósticos de enfermería al alta hospitalaria en personas con Síndrome Coronario Agudo

    Directory of Open Access Journals (Sweden)

    Clara Inés Padilla García

    2017-04-01

    Full Text Available Introducción: Enfermería juega un rol fundamental en las diferentes etapas de la atención de las personas con síndrome coronario agudo, entre ellas el egreso hospitalario. Brindar cuidado acorde a las necesidades propias de estas personas, requiere de la identificación de los principales diagnósticos de enfermería. Objetivo: Determinar la prevalencia de diagnósticos de Enfermería de las personas con síndrome coronario agudo al momento del alta hospitalaria. Metodología: Estudio de corte transversal en 196 personas hospitalizadas por el evento de interés, se utilizó instrumento de valoración focalizada que evaluaba las características definitorias de los diagnósticos de enfermería: ansiedad, afrontamiento ineficaz, disposición para mejorar la religiosidad, disposición para mejorar los conocimientos, intolerancia a la actividad; los cuales fueron identificados como prioritarios según la literatura científica y por consenso de expertos. Para determinar la prevalencia de los diagnósticos se realizó análisis de definición y características definitorias. Resultados: Se evidenció como principal problema de la población de estudio los conocimientos deficientes, seguido de la intolerancia a la actividad y la ansiedad. De igual forma se logró identificar diagnósticos positivos como la disposición para mejorar los conocimientos y la religiosidad. Conclusiones: El presente trabajo nos permitió identificar necesidades reales y reconocer factores protectores al momento del alta hospitalaria en personas que han vivido un evento coronario agudo, lo cual constituye un punto de partida para el diseño de planes de cuidado y la puesta en marcha de intervenciones que conduzcan a mejorar la situación de salud de este grupo de personas.

  13. ANALISIS COSTE-EFECTIVIDAD DE DISTINTOS MÉTODOS DE DIAGNÓSTICO POR IMAGEN DEL TROMBOEMBOLISMO PULMONAR AGUDO

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    Stella Maris Batallés

    2009-01-01

    Full Text Available La técnica diagnóstica óptima para detectar tromboembolismo pulmonar agudo (TEP continúa en discusión. La gammagrafía pulmonar de ventilación/perfusión ha sido el examen preferido durante décadas, pero con el advenimiento de nuevas pruebas de imágenes las posibilidades diagnósticas se ampliaron, siendo necesario evaluarlas desde la perspectiva del coste y de la efectividad. El objetivo de este trabajo fue evaluar distintos métodos de diagnóstico por imagen para detectar TEP agudo para determinar el más coste-efectivo. Métodos. Análisis de coste-efectividad (CE empleando un árbol de decisiones para modelar distintas pruebas (centellograma V/Q, TC helicoidal, angiografía por tomografía computada multidetector (TCMD, resonancia magnética por imágenes (RMI y arteriografía convencional. Se obtuvieron valores de sensibilidad, especificidad, valor predictivo positivo (VPP y negativo (VPN de las pruebas diagnósticas. Resultado medido: "caso detectado de TEP". Los costes evaluados fueron los directos, expresados en euros (t, incluyendo los secundarios a las complicaciones de los métodos diagnósticos. Se realizó un análisis de sensibilidad de una vía para evaluar la robustez de las conclusiones. Resultados. No se eliminaron pruebas por dominancia extendida. La tasa cruda de CE para TCMD fue de 486 t por cada caso de TEP detectado. El coste marginal entre la TC helicoidal y el centellograma V/Q fue de 103 t para detectar 8 casos adicionales de TEP, mientras que el coste marginal entre la TCMD y la TC helicoidal fue de 229 t para detectar un caso adicional de TEP. Conclusiones. La prueba diagnóstica más coste-efectiva fue la TCMD, hallazgo que mostró robustez en el análisis de sensibilidad. Sin embargo, el análisis de C-E incremental nos mostró que la TCMD costó 229 t más respeto a la TC helicoidal para lograr una mínima mejora en la efectividad de la prueba (detección de TEP agudo. El alto valor predictivo negativo de

  14. Qualidade de vida de clientes pós-infarto agudo do miocárdio Calidad de vida de los clientes pós-infarto agudo del miocardio Client's quality of life after myocardial infarction

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    Joselany Afio Caetano

    2007-03-01

    Full Text Available Objetivou-se neste estudo avaliar a qualidade de vida de clientes que sofreram infarto agudo do miocárdio. A amostra constou de 30 clientes selecionados pela busca em prontuários de uma unidade cardiológica, que nos permitiu a identificação e localização desses clientes, internados no ano de 2004. Para coleta de dados utilizamos a Escala de Qualidade de Vida de Flanagan e o tratamento estatístico com desvio-padrão. Os resultados mostraram maior índice de respostas nos níveis "indiferentes" a "pouco satisfeitos" em suas qualidades de vida. A relação interpessoal apresentou o mais alto índice de satisfação, contrariando o bem-estar físico e material, com o mais baixo índice de satisfação. Concluiu-se que a avaliação da qualidade de vida de clientes que sofreram infarto agudo do miocárdio se mostra comprometida, o que vem corroborar outros estudos anteriormente realizados.El objetivo del estudio fue evaluar la calidad de vida de los clientes que han sufrido infarto agudo del miocardio. La muestra ha consistido de 30 pacientes escogidos por la búsqueda en historias clínicas de una unidad cardiológica, que nos permitió la identificación y localización de estos clientes, internados en el año 2004. Para la colecta de los datos utilizamos la Escala de Calidad de Vida de Flanagan y el tratamiento estadístico con desvío medio. Los resultados muestran mayor índice de respuestas en los niveles "indiferentes" a "poco satisfechos" en sus calidades de vida. La relación interpersonal presentó el más alto índice de satisfacción, contrariando el bienestar físico y material, con el más bajo índice de satisfacción. Ha concluído que la evaluación de la calidad de vida de clientes que sufrieron infarto agudo del miocardio muéstrase comprometida, lo que viene a confirmar otros estudios anteriormente realizados.This study evaluates the quality of life of clients who suffered myocardial infarction. The sample consisted of 30

  15. EFEITO AGUDO DOS EXERCÍCIOS INTERMITENTES SOBRE A GLICEMIA DE ADOLESCENTES COM DIABETES TIPO 1

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    Valderi Abreu de Lima

    Full Text Available RESUMO Introdução: O exercício físico é um fator importante do tratamento do diabetes mellitus. Objetivo: Verificar o efeito agudo dos exercícios intermitentes sobre glicemia e oxidação de substratos energéticos em adolescentes com diabetes tipo 1. Métodos: Foram avaliados 10 adolescentes diabéticos com idade entre 10 e 15 anos. Foram avaliadas as medidas antropométricas, hemoglobina glicosilada (HbA1c, VO2máx e o teste de exercício intermitente. Nesse teste, os indivíduos permaneceram pedalando por 30 minutos em cicloergômetro com carga de 60% do VO2máx, intercalados com tiros de intensidades máximas de 10 segundos a cada 5 minutos. Os substratos energéticos foram avaliados durante o teste e a glicemia capilar foi medida antes, imediatamente após o exercício e 30 minutos depois. Foi observada redução média da glicemia de 39,2 ± 41,92 mg/dl, isto é, média de 21,61% da glicemia inicial. Ocorreu diferença significativa (0,0001 entre os substratos energéticos oxidados, com predominância da utilização de CHO. Há uma forte correlação direta entre a HbA1c e o escore z do IMC (r = 0,821, p = 0,004 e entre HbA1c e glicose observadas pós-exercício (r = 0,702, p = 0,024 e também há forte correlação entre os níveis de glicose pré-exercício e pós-exercício (r = 0,851, p = 0,002 e entre pós-exercício e 30 minutos depois do exercício (r = 0,874, p = 0,001. O teste de regressão linear mostrou que o escore z do IMC explica 67% dos valores de HbA1c (r² = 0,675. Resultados: De acordo com os resultados observados, 30 minutos de exercícios aeróbicos intermitentes intercalados com tiros curtos de 10 segundos promovem redução média de 21% da glicemia, com tendência de aumento na fase de recuperação. O substrato energético predominante na atividade são os carboidratos (CHO. Conclusão: Quanto melhor for o escore z do IMC do adolescente, espera-se melhor controle glicêmico em adolescentes com diabetes tipo 1.

  16. ESTRUTURA E VÍNCULOS DE UMA FAMÍLIA APÓS INFARTO AGUDO DO MIOCÁRDIO

    OpenAIRE

    Garcia, Raquel Pötter; Budó, Maria de Lourdes Denardin; Viegas, Aline da Costa; Cardoso, Daniela Habekost; Schwartz, Eda; Muniz, Rosani Manfrin

    2015-01-01

    Introdução: Conhecer os vínculos e a estrutura de uma família após episódio de Infarto Agudo do Miocárdio. Materiais e Métodos: Pesquisa qualitativa e exploratória que representa um estudo de caso desenvolvido com uma das famílias participantes. A coleta de dados ocorreu no período de fevereiro a maio de 2012, por meio de observação no domicílio e entrevista com construção do genograma e ecomapa. A intensidade dos vínculos foi definida pela família conforme legenda do ecomapa. Resultados e Di...

  17. Efeitos agudos do exercício resistido sobre marcadores da resposta inflamatória e imune

    OpenAIRE

    Guilherme Borges Pereira

    2012-01-01

    O objetivo dos pesquisadores do presente estudo foi examinar os efeitos agudos do Exercício Resistido (ER) sobre a apoptose (Anexina V+) e a migração (CX3CR1) de linfócitos T CD4+ e CD8+. 12 sujeitos adultos realizaram duas sessões de ER (3 séries em 9 exercícios) com 1 minuto (Hiper-1) e 3 minutos (Hiper-3) de intervalo entre as séries e exercícios. Não foi observada alteração significativa na contagem celular de linfócitos CD4+ e CD8+ após os protocolos Hiper-1 e Hiper-3 (p > 0,05). Foi obs...

  18. SÍNDROME CORONARIO AGUDO DE CAUSA NO ATEROESCLERÓTICA / Acute coronary syndrome of non-atherosclerotic origin

    Directory of Open Access Journals (Sweden)

    Yuri Medrano Plana

    2013-10-01

    Full Text Available Resumen La embolia coronaria es una causa poco frecuente de síndrome coronario agudo. Dentro de los varios tipos de material embólico se encuentra el de origen tumoral. Estos émbolos pueden ocasionar isquemia miocárdica de intensidad variable, desde angina de pecho hasta infarto agudo de miocardio o incluso, muerte súbita. Se presenta una mujer de 58 años de edad, que presentó episodios de angina inestable con cambios eléctricos sin factores de riesgo y sin antecedentes de cardiopatía isquémica, que en la coronariografía se demostró la presencia de arterias coronarias normales. El ecocardiograma transesofágico informó imagen ecogénica polilobulada y pediculada hacia la superficie septal de la aurícula izquierda (posible mixoma, sin observarse trombos en las cavidades cardíacas. La paciente fue operada (exéresis quirúrgica del tumor, evolucionó favorablemente y fue trasladada a su hospital de origen 72 horas después. / Abstract Coronary embolism is a rare cause of acute coronary syndrome. Among the various types of embolic material is that of tumoral origin. These emboli can cause myocardial ischemia of varying intensity, from angina to acute myocardial infarction or even sudden death. The case of a 58-year-old woman who presented unstable angina episodes with electrical changes with no risk factors and no history of ischemic heart disease is presented. By means of coronary angiography, the presence of normal coronary arteries was showed. Transesophageal echocardiography showed the echogenic polylobulated and pedicled image towards the septal surface of the left atrium (possible myxoma; thrombi in the cardiac chambers were not observed. The patient underwent surgery (surgical removal of the tumor, had a good progress and was transferred to her hospital of origin 72 hours later.

  19. O que todo intensivista deve saber a respeito da síndrome do desconforto respiratório agudo e dano alveolar difuso?

    Directory of Open Access Journals (Sweden)

    Fernando Rios

    2017-09-01

    Full Text Available RESUMO A síndrome do desconforto respiratório agudo é um desafio para o intensivista. A característica principal desta doença aguda é o dano alveolar difuso, presente em cerca de metade dos pacientes com a síndrome. É claro que o suporte respiratório à síndrome do desconforto respiratório agudo tem melhorado gradualmente nas últimas décadas. É também evidente que todos estes procedimentos são benéficos, já que reduzem a lesão pulmonar e mantêm o paciente vivo. Isto deve ser interpretado como uma estratégia de ganho de tempo, até que o fator desencadeante ou de risco causal melhore, assim como a tempestade inflamatória diminua e o pulmão se cure. Por outro lado, todos - exceto dois tratamentos farmacológicos (bloqueadores neuromusculares e esteroides - são incapazes de melhorar o desfecho da síndrome do desconforto respiratório agudo. A hipótese de que os resultados farmacológicos negativos podem ser explicados pela heterogeneidade histológica da síndrome do desconforto respiratório agudo tem sido apoiada pelas recentes demonstrações de que a síndrome com dano alveolar difuso tem característica clínico-patológica específica. O dano alveolar difuso é um diagnóstico patológico, e a biópsia pulmonar a céu aberto (a técnica mais comum para obtenção de tecido pulmonar tem efeitos colaterais graves, sendo necessário que se desenvolvam biomarcadores substitutos para o dano alveolar difuso. O objetivo desta revisão é discutir três tópicos relacionados à síndrome do desconforto respiratório agudo: o relacionamento entre a síndrome do desconforto respiratório agudo e o dano alveolar difuso; como o dano alveolar difuso pode ser representado no quadro clínico; e como o enriquecimento pode melhorar os resultados de estudos clínicos farmacológicos realizados com pacientes com a síndrome e com dano alveolar difuso.

  20. Vascular grading of angiogenesis

    DEFF Research Database (Denmark)

    Hansen, S; Grabau, D A; Sørensen, Flemming Brandt

    2000-01-01

    The study aimed to evaluate the prognostic value of angiogenesis by vascular grading of primary breast tumours, and to evaluate the prognostic impact of adding the vascular grade to the Nottingham Prognostic Index (NPI). The investigation included 836 patients. The median follow-up time was 11...... years and 4 months. The microvessels were immunohistochemically stained by antibodies against CD34. Angiogenesis was graded semiquantitatively by subjective scoring into three groups according to the expected number of microvessels in the most vascular tumour area. The vascular grading between observers...... for 24% of the patients, who had a shift in prognostic group, as compared to NPI, and implied a better prognostic dissemination. We concluded that the angiogenesis determined by vascular grading has independent prognostic value of clinical relevance for patients with breast cancer....

  1. Vascular grading of angiogenesis

    DEFF Research Database (Denmark)

    Hansen, S; Grabau, D A; Sørensen, Flemming Brandt

    2000-01-01

    The study aimed to evaluate the prognostic value of angiogenesis by vascular grading of primary breast tumours, and to evaluate the prognostic impact of adding the vascular grade to the Nottingham Prognostic Index (NPI). The investigation included 836 patients. The median follow-up time was 11...... years and 4 months. The microvessels were immunohistochemically stained by antibodies against CD34. Angiogenesis was graded semiquantitatively by subjective scoring into three groups according to the expected number of microvessels in the most vascular tumour area. The vascular grading between observers...... impact for 24% of the patients, who had a shift in prognostic group, as compared to NPI, and implied a better prognostic dissemination. We concluded that the angiogenesis determined by vascular grading has independent prognostic value of clinical relevance for patients with breast cancer....

  2. Efecto de un tratamiento intensivo con insulina sobre la reactividad plaquetaria en pacientes con hiperglucemia que ingresan con un síndrome coronario agudo

    OpenAIRE

    Vivas Balcones, Luis David

    2011-01-01

    El objetivo primario de este trabajo ha sido la valoración del efecto que produce el control estricto de la glucemia mediante un tratamiento intensivo y precoz con insulina sobre la reactividad plaquetaria durante la fase hospitalaria en pacientes que ingresan en una unidad de cuidados intensivos cardiológicos con un síndrome coronario agudo e hiperglucemia, respecto a un tratamiento convencional.

  3. Presencia y severidad de calcio coronario: su relación con la aparición de eventos coronarios agudos

    Directory of Open Access Journals (Sweden)

    Lázaro E. de la Cruz Avilés

    2012-03-01

    Full Text Available Fundamento: la detección de calcio en las arterias coronarias confirma la presencia de aterosclerosis y ha demostrado ser una herramienta útil para estratificar el riesgo cardiovascular. Objetivo: determinar la relación entre la presencia y severidad de calcio coronario con la aparición de eventos coronarios agudos. Métodos: se realizó un estudio observacional, descriptivo, prospectivo, tipo serie de casos, en el Hospital Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos, entre enero y diciembre de 2008. La serie estuvo conformada por 137 pacientes, en los que se estudió: sexo, antecedentes patológicos personales, cifras de glucemia en ayunas, creatinina, colesterol total y triglicéridos. Los pacientes fueron seguidos durante dos años para evaluar la aparición de eventos coronarios agudos. Resultados: La edad media fue de 53,2±7,4 años, con predominio del sexo masculino (52,5 %. El mayor porciento de pacientes clasificados como de alto riesgo, según la cuantificación del calcio coronario (16,8 % perteneció al sexo masculino, predominando en los mayores de 70 años. La diabetes se relacionó de forma significativa con la severidad del puntaje de calcio. El infarto agudo del miocardio fue más frecuente en pacientes con puntaje de calcio mayor de 400 unidades Agatston. Conclusiones: la aparición de eventos coronarios agudos fue más frecuente en los pacientes de alto riesgo según cuantificación del calcio coronario.

  4. Diagnóstico automático del síndrome coronario agudo utilizando un sistema multiagente basado en redes neuronales

    Directory of Open Access Journals (Sweden)

    John Jaime Sprockel Díaz

    2017-05-01

    Conclusiones: Es posible desarrollar una herramienta para el diagnóstico automático del síndrome coronario agudo a partir de un sistema multiagente que ensamble la disposición tomada por un conjunto de redes neuronales artificiales, cuyo rendimiento permite su consideración para su implementación dentro de un sistema de soporte a las decisiones clínicas.

  5. Hematologia de tilápia-do-nilo alimentada com suplemento à base de algas frente a desafios de estresse agudo e crônico

    Directory of Open Access Journals (Sweden)

    F. Garcia

    2012-02-01

    Full Text Available Avaliou-se o efeito da suplementação com produto à base de algas, ergosan, em dietas para tilápias Oreochromis niloticus, submetidas ao desafio de estresse agudo e crônico sobre as características hematológicas. O ensaio foi realizado com tilápias jovens (15g em caixas de 500L de capacidade de estocagem, em sistema com recirculação da água, com fluxo constante, na densidade de 35 peixes por caixa. Os peixes foram alimentados com as dietas-teste durante 10 dias e, ao final deste período, voltaram a receber dieta isenta de ergosan, quando foram submetidos aos desafios de estresses agudo e crônico. Utilizou-se o delineamento inteiramente ao acaso (DIC, em esquema fatorial 4x2, sendo testados: quatro porcentagens do suplemento 0; 0,25; 0,5 e 1% de ergosan na ração em dois tipos de estresse, agudo e crônico. Os resultados permitem concluir que os estímulos de estresse aplicados foram capazes de provocar alterações fisiológicas nos peixes, incluindo redução no número de eritrócitos, eritroblastos e leucócitos e aumento do volume corpuscular médio dos eritrócitos. A administração oral de 1% de suplemento durante 10 dias para juvenis de tilápia-do-nilo, em condição de estresse agudo, induz o incremento de 69% no número de trombócitos circulantes.

  6. Rechazo al cuidado de la salud por motivaciones del paciente Rejeição ao cuidado da saúde por motivações do paciente Health care rejection due to patient motivations

    Directory of Open Access Journals (Sweden)

    Oscar Alberto Beltrán Salazar

    2010-07-01

    Full Text Available Objetivo. Describir el significado que tiene para los pacientes del rechazo al cuidado de la salud. Metodología. Investigación cualitativa con enfoque fenomenológico realizada en Medellín (Colombia entre 2008 y 2009. Incluyó a 12 adultos hospitalizados. La entrevista en profundidad se utilizó para la recolección de información. Los datos se analizaron según el esquema propuesto por Cohen, Kahan y Steeves. Resultados. El temor, el sufrimiento, la dependencia así como el desconocimiento y la "mala fama" de profesionales, instituciones o procedimientos contribuyen a la respuesta de rechazo al cuidado. Los pacientes rechazan la enfermedad por el dolor y el sufrimiento. El conocimiento juega un doble papel en el cuidado de la salud porque ayuda a aceptar o rechazar el cuidado y a promover aceptación y satisfacción de los pacientes. Conclusión. El rechazo es una decisión de los pacientes en respuesta a situaciones relacionadas con la enfermedad, el conocimiento y los comportamientos de los enfermeros y debe ser tenido en cuenta por los enfermeros.Objetivo. descrever o significado que tem para os pacientes da rejeição ao cuidado da saúde. Metodologia. investigação qualitativa com enfoque fenomenológico realizada em Medellín (Colômbia entre 2008 e 2009. Incluiu a 12 adultos hospitalizados. A entrevista em profundidade se utilizou para recolher informação. Os dados se analisaram segundo o esquema proposto por Cohen, Kahan e Steeves. Resultados. o temor, o sofrimento, a dependência bem como o desconhecimento e a "má fama" de profissionais, instituições ou procedimentos contribuem à resposta de rejeição ao cuidado. Os pacientes recusam a doença pela dor e o sofrimento. O conhecimento joga um duplo papel no cuidado da saúde porque ajuda a aceitar ou recusar o cuidado e a promover aceitação e satisfação dos pacientes. Conclusão. A rejeição é uma decisão dos pacientes em resposta a situações relacionadas com a doen

  7. Análise das barreiras à utilização de trombolíticos em casos de acidente vascular cerebral isquêmico em um hospital privado do Rio de Janeiro, Brasil

    OpenAIRE

    Fonseca,Luiz Henrique de Oliveira; Rosa,Maria Luiza Garcia; Silva,Arthur Carvalho; Maciel,Renan Marchesi; Volschan,André; Mesquita,Evandro Tinoco

    2013-01-01

    O acidente vascular cerebral isquêmico (AVCi) é uma importante causa de sequela e morte. A correta utilização do trombolítico enfrenta várias barreiras. O objetivo foi discutir as barreiras à terapia trombolítica em pacientes que chegam, com sintomas de AVCi agudo, à emergência de um hospital privado do Rio de Janeiro, Brasil. Coorte retrospectiva de pacientes entre 2009 e 2011. Foram admitidos 257 pacientes com suspeita de AVCi. Dos pacientes com diagnóstico confirmado (156), 11,5% (18) fora...

  8. Vascular Access in Children

    International Nuclear Information System (INIS)

    Krishnamurthy, Ganesh; Keller, Marc S.

    2011-01-01

    Establishment of stable vascular access is one of the essential and most challenging procedures in a pediatric hospital. Many clinical specialties provide vascular service in a pediatric hospital. At the top of the “expert procedural pyramid” is the pediatric interventional radiologist, who is best suited and trained to deliver this service. Growing awareness regarding the safety and high success rate of vascular access using image guidance has led to increased demand from clinicians to provide around-the-clock vascular access service by pediatric interventional radiologists. Hence, the success of a vascular access program, with the pediatric interventional radiologist as the key provider, is challenging, and a coordinated multidisciplinary team effort is essential for success. However, there are few dedicated pediatric interventional radiologists across the globe, and also only a couple of training programs exist for pediatric interventions. This article gives an overview of the technical aspects of pediatric vascular access and provides useful tips for obtaining vascular access in children safely and successfully using image guidance.

  9. Pediatric vascular access

    International Nuclear Information System (INIS)

    Donaldson, James S.

    2006-01-01

    Pediatric interventional radiologists are ideally suited to provide vascular access services to children because of inherent safety advantages and higher success from using image-guided techniques. The performance of vascular access procedures has become routine at many adult interventional radiology practices, but this service is not as widely developed at pediatric institutions. Although interventional radiologists at some children's hospitals offer full-service vascular access, there is little or none at others. Developing and maintaining a pediatric vascular access service is a challenge. Interventionalists skilled in performing such procedures are limited at pediatric institutions, and institutional support from clerical staff, nursing staff, and technologists might not be sufficiently available to fulfill the needs of such a service. There must also be a strong commitment by all members of the team to support such a demanding service. There is a slippery slope of expected services that becomes steeper and steeper as the vascular access service grows. This review is intended primarily as general education for pediatric radiologists learning vascular access techniques. Additionally, the pediatric or adult interventional radiologist seeking to expand services might find helpful tips. The article also provides education for the diagnostic radiologist who routinely interprets radiographs containing vascular access devices. (orig.)

  10. Modelos de serviços hospitalares para casos agudos em idosos Hospital services for acute care of elderly people

    Directory of Open Access Journals (Sweden)

    João Macedo Coelho Filho

    2000-12-01

    Full Text Available Embora a atenção ao idoso seja uma prioridade emergente no Brasil, pouca ênfase tem sido dada a modelos de organização de serviços hospitalares para pacientes geriátricos. São revisados modelos de serviços hospitalares para admissão e manuseio de casos agudos em idosos, com ênfase na discussão sobre o papel e o posicionamento da medicina geriátrica (incluindo sua interface com especialidades e com a clínica médica no âmbito da atenção hospitalar. Foi realizada pesquisa na base de dados Medline (1989-1999, bem como nos principais livros-texto de geriatria e de gerontologia, buscando identificar descrições de serviços hospitalares para cuidado agudo de pacientes idosos. As características dos modelos identificados foram compiladas e descritas à luz de sua adequação à realidade dos serviços de saúde no Brasil. Exemplos de intervenções em geriatria, com efetividade demonstrada através de revisões sistemáticas, foram também citadas. Os modelos mais freqüentemente relatados foram cuidado prolongado, tradicional, baseado na idade cronológica, não especializado e integrado. Adaptações e variantes de alguns desses modelos foram freqüentemente relatadas, assim como seu impacto potencial na efetividade do cuidado geriátrico. Evidências sobre o melhor modelo a seguir não foram identificadas, mas aqueles modelos favorecendo a integração da geriatria com a clínica geral pareceram mais adequados à nossa realidade. Ressalta a necessidade de reestruturação de serviços de saúde para responder às novas demandas que surgem com o envelhecimento da população, bem como do delineamento de serviços hospitalares para casos agudos, importantes para a efetividade do cuidado geriátrico e que devem ser objeto de maior debate e pesquisa no Brasil.Although the implementation of geriatric services is an emerging priority in Brazil, little emphasis has been put on the type of acute care that should be provided for elderly

  11. Vascular malformations in pediatrics

    International Nuclear Information System (INIS)

    Reith, W.; Shamdeen, M.G.

    2003-01-01

    Vascular malformations are the cause of nearly all non-traumatic intracranial hemorrhage in children beyond the neonatal stage. Therefore, any child presenting with spontaneous intracranial hemorrhage should be evaluated for child abuse and for vascular malformations. Intracerebral malformations of the cerebral vasculature include vein of Galen malformations, arteriovenous malformation (AVM), cavernomas, dural arteriovenous fistulas, venous anomalies (DVA), and capillary teleangiectasies. Although a few familial vascular malformation have been reported, the majority are sporadic. Clinical symptoms, diagnostic and therapeutic options are discussed. (orig.) [de

  12. EFEITO AGUDO DO LASER DE BAIXA POTÊNCIA NA FADIGA DO BÍCEPS BRAQUIAL DE ATLETAS DE VOLEIBOL

    Directory of Open Access Journals (Sweden)

    Juliana Lôbo Froio

    Full Text Available RESUMO Introdução: A laserterapia de baixa potência tem entre seus propósitos auxiliar a recuperação de tecidos biológicos, atenuando os efeitos da fadiga muscular e contribuindo com a melhora do desempenho em atletas. Aspectos metodológicos ainda limitam as conclusões do efeito agudo da laserterapia sobre o desempenho muscular. Objetivo: Verificar o efeito agudo do laser terapêutico de baixa potência na fadiga induzida do bíceps braquial de atletas de voleibol. Métodos: Este foi um estudo randomizado e duplo-cego, aprovado pelo Comitê de Ética da UNESP de Marília. Participaram do estudo 19 atletas de voleibol de ambos os sexos. Realizou-se coleta de dados eletromiográficos do músculo bíceps braquial no exercício isométrico de flexão de cotovelo antes e após a aplicação do laser terapêutico. Um haltere com 75% do pico de força, obtido por uma célula de carga, foi utilizado para o protocolo de fadiga. Em seguida, os voluntários foram submetidos à aplicação do laser (ativo ou placebo em seis pontos do músculo bíceps braquial. Os dados eletromiográficos foram analisados no domínio da frequência, utilizando-se o software Myosystem®. Verificou-se a distribuição de normalidade dos dados pelo teste de Shapiro-Wilk, e utilizou-se Anova (split plot de medidas repetidas a fim de testar a interação entre tempo e grupo. Resultados: Para nenhuma das variáveis analisadas foi observada interação significativa entre grupo e tempo, indicando que o grupo irradiado não apresentou vantagens com relação ao grupo placebo. Conclusão: Após o protocolo de fadiga proposto, uma única aplicação de laser de baixa potência não foi suficiente para produzir efeitos positivos no desempenho de força e no sinal eletromiográfico do músculo bíceps braquial de atletas de voleibol.

  13. Prevalência de fatores de risco em pacientes com infarto agudo do miocárdio

    Directory of Open Access Journals (Sweden)

    Simone Mathioni Mertins

    2016-01-01

    Full Text Available Objetivo: Identificar a prevalência de fatores de risco em pacientes com infarto agudo do miocárdio, internados em uma Unidade de Terapia Intensiva Coronariana de um hospital da região noroeste do estado do Rio Grande do Sul ̸ Brasil. Metodologia: Estudo quantitativo, descritivo e transversal, realizado no período compreendido entre 25 de abril a 25 de junho de 2012, com 48 pacientes. As variáveis de interesse para este estudo foram as condições sociodemográficas, dados antropométricos, hábitos alimentares e fatores de risco cardiovascular. Resultados: A idade média foi de 59,9 ± 11,55 anos, com predominância do sexo masculino (81,3%, de cor branca (83,3%, casados (70,8%, ensino fundamental incompleto (72,9%, aposentados (37,5%, renda menor que três salários mínimos (58,3% e procedentes da região urbana (72,9%. A prevalência dos fatores de risco se distribuiu da seguinte forma: sedentarismo (91,7%, hipertensão arterial sistêmica (63,8%, estresse (50%, circunferência abdominal alterada (50%, história familiar (43,7%, tabagismo (41,7%, sobrepeso (35,5%, obesidade (33,4%, dislipidemia (23%, diabetes mellitus (20,8% e consumo de álcool (12,5%. Conclusão: Os dados apresentados mostram a elevada prevalência de fatores de risco em pacientes que tiveram infarto agudo do miocárdio e nos direcionam a entender o papel da educação em saúde como estratégia para reduzir as causas de morbimortalidade, além de propor ações de cuidado e autocuidado e mudanças nos hábitos de vida.  Descritores: Fatores de Risco; Infarto do Miocárdio; Educação em Saúde (Fontes: DeCS e BIREME.

  14. EFECTO DE LA COLOCACIÓN DE DISPOSITIVOS ELÁSTICOS DE HULE, EN LAS MANOS SUPERIORES DEL RACIMO DE BANANO, SOBRE LA CONFORMACIÓN DE LA MANO, EL RECHAZO DE FRUTOS Y LA RELACIÓN CAJAS-RACIMO

    Directory of Open Access Journals (Sweden)

    Alfonso Vargas

    2012-01-01

    rechazo de frutos, en especial aquellos correspondientes a frutos deformes o a lesiones por el roce entre ellos durante su crecimiento en el racimo (cicatriz de crecimiento, no fueron afectados por el uso o no de la BEH en ninguno de los experimentos en donde ello se evaluó. El número de cajas obtenidas a partir de las 5 manos superiores del racimo no permitió definir la superioridad entre el uso o no de la BEH.

  15. Troponina T vs Troponina I como Valor Predictivo para Síndrome Coronario Agudo en menores de 80 Años

    Directory of Open Access Journals (Sweden)

    PE Pla Cala

    2015-07-01

    Full Text Available Resumen – Actualmente en la injuria miocárdica, ha tenido gran relevancia clínica la utilidad de las troponinas como método diagnóstico, repercutiendo en el manejo del síndrome coronario agudo. Objetivo: Analizar la importancia de los biomarcadores troponina T e I y otros elementos adyuvantes que cumplen un papel trascendental como es el electrocardiograma y los diferentes métodos invasivos, el cual brinda una orientación para la concepción de un diagnóstico oportuno que permita tomar las acciones pertinentes en un paciente con síndrome coronario agudo. Materiales y Métodos: Estudio descriptivo comparativo en 35 pacientes, adultos mayores de 21 años y menores 80 años, que se encontraban hospitalizados en la Empresa Social del Estado Centro de Atención y Rehabilitación Integral - E.S.E CARI de Alta complejidad, en el periodo comprendido entre el año 2012 a 2014. Resultados: Los pacientes presentaron síndrome coronario agudo (infarto agudo de miocardio con o sin elevación del ST, con factores de riesgo cardiovascular tales como: sedentarismo, tabaquismo, hipertensión arterial, diabetes, valvulopatías, dislipidemia y antecedentes de cardiopatía isquémica. El punto a analizar fue la elevación de los biomarcadores troponina T y troponina I en un periodo menor y mayor a 3 horas, desde el inicio de los síntomas (dolor torácico, criodiaforesis, disnea hasta el ingreso a la institución hospitalaria. Se compararon los resultados obtenidos de cada uno de estos biomarcadores en el diagnóstico precoz y oportuno del síndrome coronario agudo. De las muestra analizada (n=35 pacientes se obtuvo que la troponina T< 3 horas se elevó un 76.4% en rangos de edad entre los 60-80 años en contraste con troponina I < 3 horas en ese mismo grupo etario que fue de 70.5%. Conclusiones: se evidenció que ambos biomarcadores son equiparables con una ligera ventaja de la troponina T con respecto a la I.

  16. Uterine Vascular Lesions

    Science.gov (United States)

    Vijayakumar, Abhishek; Srinivas, Amruthashree; Chandrashekar, Babitha Moogali; Vijayakumar, Avinash

    2013-01-01

    Vascular lesions of the uterus are rare; most reported in the literature are arteriovenous malformations (AVMs). Uterine AVMs can be congenital or acquired. In recent years, there has been an increasing number of reports of acquired vascular lesions of the uterus following pregnancy, abortion, cesarean delivery, and curettage. It can be seen from these reports that there is confusion concerning the terminology of uterine vascular lesions. There is also a lack of diagnostic criteria and management guidelines, which has led to an increased number of unnecessary invasive procedures (eg, angiography, uterine artery embolization, hysterectomy for abnormal vaginal bleeding). This article familiarizes readers with various vascular lesions of the uterus and their management. PMID:24340126

  17. Magnetic resonance vascular imaging

    International Nuclear Information System (INIS)

    Axel, L

    1989-01-01

    The basis principles of MRI are reviewed in order to understand how blood flow effects arise in conventional imaging. Then some of the ways these effects have ben used in MRI techniques specifically designed for vascular imaging, are considered. (author)

  18. Infarto agudo de miocardio. Guía de práctica clínica

    Directory of Open Access Journals (Sweden)

    Yanier Coll Muñoz

    2011-08-01

    Full Text Available

    La elaboración de esta Guía de Práctica Clínica se justifica, en primer lugar, por la elevada frecuencia de presentación y mortalidad del infarto agudo del miocardio en la población general. Las enfermedades cardiovasculares constituyen en la actualidad la principal causa de muerte en los países industrializados, y se espera que también lo sean en los países en vías de desarrollo en el año 2020.  La presente guía se refiere a los pacientes que presentan síntomas isquémicos o sus equivalentes, y una elevación persistente del segmento ST en el electrocardiograma, o cambios del electrocardiograma de infradesnivel del ST o de la onda T, compatibles con el diagnóstico de IAM sin elevación del ST. Esta Guía no aborda los elementos relacionados directamente con los procedimientos de intervencionismo coronario percutáneo ni la revascularización miocárdica quirúrgica.

  19. Efeito agudo do método de facilitação neuromuscular proprioceptiva na flexibilidade de bailarinas

    Directory of Open Access Journals (Sweden)

    Giane Andreia Souza Siqueira

    2013-11-01

    Full Text Available Objetivo: Verificar a resposta aguda do método de Facilitação Neuromuscular Proprioceptiva (FNP na flexibilidade e a influência das variáveis idade, peso, estatura em praticantes de Ballet Clássico. Método: A amostra foi composta por 11 bailarinas, com média de idade de 10,91 ± 0,79 anos praticantes regularmente de Ballet clássico duas vezes por semana com no mínimo de 5 anos de experiência. Foi utilizado o método de FNP nas bailarinas. Para avaliação da flexibilidade foi utilizado o Banco de Wells. Para analise estatística utilizou o teste de “t” de Student para amostras dependentes e análise de regressão Stepwise Forward com p≤0,05. Resultado:A diferença média de amplitude de movimento foi 4,81 ± 1,99 cm. Já a variável estatura demonstrou-se influenciar significativamente na flexibilidade. O método FNP demonstrou efeito agudo significativo na flexão de quadril em bailarinas.

  20. Overview of vascular disease

    International Nuclear Information System (INIS)

    Bisset, G.S. III

    1998-01-01

    Vascular disease in the pediatric population is a poorly understood process which is often underestimated in its incidence. The common beginnings of such ubiquitous diseases as atherosclerosis manifest themselves at a cellular level shortly after birth. Other common systemic disorders, including congestive heart failure and sepsis, are also intricately associated with dysfunctional vasculature. Progress in the understanding of normal and pathophysiologic processes within the vascular system begins with the 'control center' - the endothelial cell. The purpose of this review is to consolidate a body of knowledge on the processes that occur at the cellular level within the blood vessel wall, and to simplify the understanding of how imbalances in these physiologic parameters result in vascular disease. (orig.)

  1. Atención farmacéutica en personas que han sufrido episodios coronarios agudos (estudio TOMCOR

    Directory of Open Access Journals (Sweden)

    Álvarez de Toledo Flor

    2001-01-01

    Full Text Available Fundamento: Este estudio valora los efectos de un nuevo modelo de trabajo en las farmacias, denominado Atención Farmacéutica, frente al modelo tradicional. Se pretende conocer su factibilidad y las diferencias, potencialmente debidas a la Atención Farmacéutica, respecto de los resultados de salud de la farmacoterapia usada, en una muestra de pacientes que han sufrido episodios coronarios agudos. Métodos: Es un estudio prospectivo con un grupo de intervención (330 personas y un grupo control (405 personas, realizado en 83 farmacias de Asturias, Barcelona, Madrid y Vizcaya, en las que se hizo seguimiento durante un año del uso de medicamentos en 735 personas, de las cuales finalizaron el estudio 600. Resultados: Hubo diferencias favorables al grupo intervención, respecto de: a uso de servicios sanitarios indicativos de mayor morbilidad, tales como la frecuencia de consultas hospitalarias urgentes por paciente 1,27Interv. (IC95 %:1,10 a 1,44 y 1,63Contr.(IC95 %:1,36 a 1,90 o los días promedio de UCI por paciente hospitalizado: 2,46Interv.(IC95 %:1,56 a 3,36 y 5,87Contr.(IC95 %: 3,57 a 8,17, por causa cardiológica; b calidad de vida con diferencia de 4,7 (p < 0,05 en la dimensión de función física; c conocimiento de factores de riesgo de enfermedad coronaria, promedio de +10 % (p < 0,02 - 0,07, según dimensión; d identificación nominal de los medicamentos usados +10 % (p < 0,01; importancia subjetiva otorgada a los antiagregantes + 12 % (p < 0,009, los beta-bloqueantes, así como sus efectos +25 % (p < 0,02; y e satisfacción con la AF y percepción de la competencia profesional, promedio de + 12 % (p < 0,000 - 0,05, según dimensión. Conclusiones: Los valores menores de: demanda individual urgente coronaria, frecuencia de hospitalizaciones y número de días de Unidad de Cuidados Intensivos coronaria por hospitalización, sugerirían que los pacientes que tras un episodio coronario agudo reciben Atención Farmacéutica tienden a

  2. Atención farmacéutica en personas que han sufrido episodios coronarios agudos (estudio tomcor

    Directory of Open Access Journals (Sweden)

    Flor Álvarez de Toledo

    2001-01-01

    Full Text Available Fundamento: Este estudio valora los efectos de un nuevo modelo de trabajo en las farmacias, denominado Atención Farmacéutica, frente al modelo tradicional. Se pretende conocer su factibilidad y las diferencias, potencialmente debidas a la Atención Farmacéutica, respecto de los resultados de salud de la farmacoterapia usada, en una muestra de pacientes que han sufrido episodios coronarios agudos. Métodos: Es un estudio prospectivo con un grupo de intervención (330 personas y un grupo control (405 personas, realizado en 83 farmacias de Asturias, Barcelona, Madrid y Vizcaya, en las que se hizo seguimiento durante un año del uso de medicamentos en 735 personas, de las cuales finalizaron el estudio 600. Resultados: Hubo diferencias favorables al grupo intervención, respecto de: a uso de servicios sanitarios indicativos de mayor morbilidad, tales como la frecuencia de consultas hospitalarias urgentes por paciente 1,27Interv. (IC95 %:1,10 a 1,44 y 1,63Contr.(IC95 %:1,36 a 1,90 o los días promedio de UCI por paciente hospitalizado: 2,46Interv.(IC95 %:1,56 a 3,36 y 5,87Contr.(IC95 %: 3,57 a 8,17, por causa cardiológica; b calidad de vida con diferencia de 4,7 (p < 0,05 en la dimensión de función física; c conocimiento de factores de riesgo de enfermedad coronaria, promedio de +10 % (p < 0,02 - 0,07, según dimensión; d identificación nominal de los medicamentos usados +10 % (p < 0,01; importancia subjetiva otorgada a los antiagregantes + 12 % (p < 0,009, los beta-bloqueantes, así como sus efectos +25 % (p < 0,02; y e satisfacción con la AF y percepción de la competencia profesional, promedio de + 12 % (p < 0,000 – 0,05, según dimensión. Conclusiones: Los valores menores de: demanda individual urgente coronaria, frecuencia de hospitalizaciones y número de días de Unidad de Cuidados Intensivos coronaria por hospitalización, sugerirían que los pacientes que tras un episodio coronario agudo reciben Atención Farmacéutica tienden a

  3. La vivencia del rechazo en homosexuales universitarios de la Ciudad de México y situaciones de riesgo para VIH/sida The experience of rejection in homosexual university students from Mexico City and risk situations for HIV/AIDS.

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    José Arturo Granados-Cosme

    2009-12-01

    Full Text Available OBJETIVO: Describir la relación que establece un grupo de varones homosexuales entre la percepción del rechazo social a su homosexualidad, sus prácticas sexuales y el riesgo de VIH/sida. MATERIAL Y MÉTODOS: Se aplicaron entrevistas a profundidad a homosexuales de una universidad de la Ciudad de México reclutados mediante la técnica de "bola de nieve". Las entrevistas se grabaron y procesaron en el programa Atlas.ti y el análisis del discurso se realizó con el método denominado "teoría fundamentada". RESULTADOS: La experiencia de la homofobia que manifestaron los entrevistados generó sufrimiento psíquico, incluidos tristeza, miedo y conducta suicida, asociado con situaciones de riesgo para VIH/sida: escasa comunicación, baja negociación para usar el condón y prácticas de riesgo como la penetración anal. CONCLUSIONES: La homofobia, traducida en discriminación, incrementa la vulnerabilidad a la transmisión sexual del VIH.OBJETIVES: To describe the relationship established by a male homosexual group between the perception of social rejection towards their homosexuality, sexual practices and risk of HIV/AIDS. MATERIAL AND METHODS: In-depth interviews were administered to homosexual men at a Mexico City university by means of a snowball technique. The interviews were recorded and processed with Atlas.ti software and the analysis of the discourse was made using the Grounded Theory method. RESULTS: The experience of homophobia as expressed by the interviewees resulted in psychological suffering, including sadness, fear, loneliness and suicidal behavior associated with risk situations for HIV/AIDS. CONCLUSIONS: Homophobia, translated into discrimination, contributes to an increased vulnerability to the sexual transmission of HIV.

  4. ¿Aceptación o rechazo de la estandarización clínica? Médicos chilenos hablan de las guías clínicas y canastas de prestaciones

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    Sebastián Lemp

    2012-01-01

    Full Text Available Este estudio analiza la aceptación de los médicos respecto de la estandarización de la atención clínica que conlleva la reforma de Acceso Universal con Garantías Explícitas (AUGE y de Garantías Explícitas en Salud (GES iniciada en el año 2005 en Chile. Se realizaron 18 entrevistas semiestructuradas, en las que se exploran cuatro hipótesis vinculadas al nivel de aceptación de la estandarización y su variación según los años de práctica clínica, el tipo de instrumento (guía clínica o canasta de prestaciones y la especialidad (médica o quirúrgica. Los resultados sugieren que no existe un rechazo generalizado hacia la estandarización de los procesos clínicos, sino importantes diferencias en el discurso de los médicos. El grado de aceptación depende tanto de los años de experiencia clínica como del tipo de instrumento evaluado. Se discute la implicancia de estos resultados para diseñar e implementar reformas de salud exitosas, que consideren la racionalidad de la profesión médica y su énfasis en la discrecionalidad individual, variabilidad terapéutica y capacidad para adecuarse a las circunstancias particulares de su práctica.

  5. Daño pulmonar agudo relacionado con la transfusión (Trali y Bartonelosis aguda

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    Douglas López de Guimaraes

    2006-07-01

    Full Text Available Se presenta el caso de un varón de 22 años procedente de la periferia de la ciudad de Huaraz, Perú, que acude al Hospital "Victor Ramos Guardia" de Huaraz con un tiempo de enfermedad de 14 días, febril, pálido e ictérico, en el frotis de sangre periférica se encuentran formas bacilares de Bartonella bacilliformis en 99% de la lámina; se inicia tratamiento antibiótico con ceftriaxona y ciprofloxacino. Al día siguiente se le indica transfusión de dos paquetes globulares (puesto que tenía 6,2 g/dL de Hb, dos horas después presenta dolor toráxico, tos seca exigente, vómitos, dificultad respiratoria y cianosis, en la auscultación se encuentran roncantes y crepitantes, la radiografía de tórax muestra infiltrado alveolar difuso a predominio derecho. Es trasladado a la UCI donde recibe oxígeno con máscara de reservorio, dopamina, corticoides y se inicia el monitoreo hemodinámico; responde en forma satisfactoria, sale de alta con frotis negativo a Bartonella bacilliformis. Es el primer caso de daño pulmonar agudo relacionado con la transfusión (TRALI asociado con Bartonelosis aguda con cuadro clínico - radiológico y evolución compatible, es importante distinguir entre la complicación pulmonar debido a la sepsis grave por Bartonelosis aguda, que puede producir un cuadro clínico similar y el TRALI.

  6. Terapia ocupacional en un hospital general de pacientes agudos = Occupational therapy in a general hospital for acute pacients

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    Ocello, M. G

    2006-09-01

    Full Text Available RESUMEN Desde su creación, el Hospital Provincial “Dr. José María Cullen” posee la característica de ser un hospital de emergencias, sostenido por la Sociedad de Beneficencia y la Hermanas de la Caridad.Su funcionamiento responde a un Modelo Clínico-Asistencial, lo cual influye en la inserción de Terapia Ocupacional debiendo adaptar sus funciones a las características de la Institución.Los marcos de referencia teóricos y programas que se implementandeber ser acordes con las necesidades surgidas de un Hospital General de Agudos y de emergencias.En el Sector de Terapia Ocupacional se desarrolla la actividad docente cumpliendo con los requisitos reglamentados por el Ministerio de Salud de la Provincia de Santa Fe.ABSTRACT Ever since its start the Provincial Hospital “Dr. José María Cullen” is characterised for being an emergency hospital under the guidance of the Benfit Society of Hermanas de la Caridad.Its function responds to a Clinical Assistential Model, which influences the insertion of Occupational Therapy, adapting its functiones to the characteristics of the Institution as and when called for.The theoretical points of reference and programmes that are used must be in accordance with tehe necessities that appear in an Acute and Emergency General Hospital.In the Occupational Therapy Sector the teaching activity is developed as required by rules and regulations of the Ministry of Health for the Province of Santa Fe.

  7. Fibrilação atrial, infarto agudo do miocárdio e oclusão arterial aguda em paciente jovem com hipertireoidismo

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    Fabrício Thebit Bortolon

    2009-09-01

    Full Text Available Relato de caso de paciente jovem com hipertireoidismo não diagnosticado, apresentando quadro de fibrilação atrial, infarto agudo do miocárdio e oclusão arterial aguda de perna direita. Submetido à trombólise, embolectomia e iniciado tratamento para hipertireoidismo com tapazol. A evolução foi satisfatória, com reversão da alteração eletrocardiográfica isquêmica, melhora dos sintomas de oclusão arterial, controle do ritmo cardíaco e da função tireoidiana.

  8. Sistema informático para la gestión de la información hospitalaria del infarto agudo de miocardio (RHIMA

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    Yanier Coll Muñoz

    2015-10-01

    Full Text Available Introducción: La difícil recopilación de información sobre la prevalencia y desarrollo del infarto agudo de miocardio imposibilita medir la calidad del tratamiento durante la evolución de la enfermedad en un determinado grupo de pacientes.Objetivo: Desarrollar un sistema informático que permita la gestión de la información hospitalaria del infarto agudo de miocardio en el Servicio de Cardiología.Método: Se identificaron las variables necesarias para la confección del registro, divididas por bloques relacionados con la atención prehospitalaria, el síndrome coronario agudo, la atención en Unidades de Cuidados Coronarios y el egreso. Se creó un sistema informático que utiliza NetBeans como IDE de programación, Apache como servidor web y la base de datos en MySQL; como lenguaje de programación se utilizó PHP con la infraestructura digital (framework Yii del lado del servidor y JavaScript con el framework ExtJs 4.1.1 del lado del cliente. Como modelador de base de datos se utilizó ER/Studio.Resultados: Se conformó el Registro Hospitalario de Infarto Agudo de Miocardio (RHIMA para su aplicación en el Hospital Gustavo Aldereguía Lima de Cienfuegos, Cuba; se lograron obtener datos estadísticos inmediatos que permitieron realizar un análisis de la atención a los pacientes con esta enfermedad.Conclusiones: Se desarrolló un sistema informático web capaz de gestionar la información del IAM. Su diseño, acorde al Sistema Nacional de Salud de Cuba, tiene en cuenta las características epidemiológicas y demográficas de la población cubana y brindan indicadores de calidad en la terapéutica para el registro de la información del IAM, ajustadas a las recomendaciones de las principales Guías de Práctica Clínica.

  9. O problema do trabalho infantil na agricultura familiar: o caso da produção de tabaco em Agudo-RS

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    Joel Orlando Bevilaqua Marin

    2012-12-01

    Full Text Available O objetivo do artigo é analisar a emergência do problema do trabalho infantil no cultivo de tabaco em Agudo, desencadeado pela promulgação do Decreto n. 6.481/2008, que trata das piores formas de trabalho infantil. Os procedimentos metodológicos utilizados foram a revisão bibliográfica, pesquisa documental e um estudo de caso, realizado no município de Agudo, Rio Grande do Sul. No estudo de caso, procurou-se obter dados quantitativos e qualitativos, por meio de questionários e entrevistas abertas, dirigidos para 27 agricultores familiares fumicultores, com filhos com menos de 18 anos de idade. Os resultados da pesquisa indicam a existência de um confronto entre diferentes concepções sobre o trabalho da criança no âmbito da agricultura familiar. Os dispositivos legais, os termos de compromissos e os contratos de integração na cadeia produtiva do fumo proíbem o trabalho de menores de 18 anos, fundamentando-se nos princípios internacionais da garantia do pleno desenvolvimento das crianças. Na perspectiva das famílias, o trabalho das crianças é entendido como "ajuda", forma de socialização e formação dos herdeiros. Portanto, os pais não concordam que se trata de uma forma perversa de exploração do trabalho dos próprios filhos.The aim of this paper is to analyze the emergence of the child labor problem in tobacco growing in Agudo (Rio Grande do Sul state, triggered by the promulgation of Act 6.481/2008, which addresses the worst child labor conditions. The methodological procedures used were the literature review, desk research and a case study, conducted in the municipality of Agudo. In the case study, we have tried to obtain quantitative and qualitative data through questionnaires and open interviews directed to 27 tobacco growers, and with teenagers and children under 18 years old. The survey results indicate the existence of a clash between different conceptions of child labor in small scale family farmers. The legal

  10. Impacto Pronóstico de los Síndromes Geriátricos en Pacientes Ancianos con Síndrome Coronario Agudo

    OpenAIRE

    Bonanad Lozano, Clara

    2015-01-01

    Los síndromes geriátricos pueden predecir eventos adversos en el contexto del síndrome coronario agudo más allá de la propia edad y de los clásicos factores de riesgo cardiovascular. El objetivo de la presente tesis doctoral fue cuantificar y evaluar un amplio espectro de síndromes geriátricos en pacientes supervivientes a la fase aguda de un síndrome coronario. Se incluyeron un total de 342 pacientes mayores de 65 años que ingresaron de forma consecutiva en el servicio de Cardiología de un ú...

  11. Hiperalimentação enteral em traumatismos crânio-encefálicos agudos reposição ou dietoterapia?

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    Arthur Schelp

    1992-06-01

    Full Text Available Os autores apresentam revisão geral sobre a fisiopatogenia do trauma, ressaltando os estados de hipereatabolismo e hipermetabolismo, suas consequências nutricionais, com as particularidades do trauma encefálico. São feitas, também, considerações sobre as vias, composição e volumes das dietas enterais a serem administradas a pacientes com trauma agudo encefálico, assim como são apontadas questões a serem melhor elucidadas.

  12. Fluidoterapia entérica versus fluidoterapia endovenosa em casos de síndrome de abdómen agudo em equinos

    OpenAIRE

    Mancha, Dora Alexandra Inácio

    2009-01-01

    Dissertação de Mestrado Integrado em Medicina Veterinária O Síndrome de Abdómen Agudo é uma patologia muito frequentemente encontrada na prática clínica de equinos. A hidratação dos cavalos com dor abdominal aguda é extremamente importante. Por este motivo, a abordagem terapêutica médica destes animais inclui quase invariavelmente a administração de fluidos. O médico veterinário pode recorrer à fluidoterapia entérica e à fluidoterapia endovenosa para o tratamento destes animais...

  13. Mortalidad por enfermedad de Chagas: A propósito de los brotes de Chagas agudo como enfermedad reemergente de transmisión alimentaria

    OpenAIRE

    Rísquez, Alejandro

    2009-01-01

    Tras la ocurrencia de los primeros brotes de Chagas agudos en la capital (diciembre 2007) y Estado Vargas (marzo 2009) por trasmisión oral, se procedió a una revisión de la mortalidad por la enfermedad registrada entre 1997 y 2006, cuyos datos se analizaron de acuerdo a la edad, sexo y forma de presentación. El número absoluto de muertes sigue siendo elevado con promedio de 796 muertes anuales, de predominio en el sexo masculino, la mayoría en después de los 60 años de edad. Llama la atención...

  14. Efectos agudos de la actividad física y los videojuegos activos sobre las funciones cognitivas en jóvenes y adultos mayores

    OpenAIRE

    López García, Jesús

    2017-01-01

    La presente tesis doctoral consiste en intentar aportar nuevas evidencias científicas que traten de ampliar y clarificar el conocimiento existente referente a los efectos agudos de la actividad física aeróbica y los videojuegos activos sobre las funciones cognitivas en dos muestras poblacionales diferentes: los jóvenes adultos y los adultos mayores. Como síntesis general, podríamos indicar que el fin de las series experimentales desarrolladas en esta tesis tratan de estudiar si la práctic...

  15. Comportamiento del infarto agudo del miocardio en personas con diabetes mellitus de la provincia Granma Situation of the acute myocardial infarction in persons with diabetes mellitus in Granma province

    OpenAIRE

    Eduardo René Valdés Ramos; Marjoris Rivera Chávez; Niurka Bencosme Rodríguez

    2012-01-01

    Antecedentes: la diabetes mellitus, además de ser un factor de riesgo para el infarto agudo del miocardio, parece conferir per se un peor pronóstico en los pacientes con esta entidad. Objetivo: evaluar el comportamiento del infarto agudo del miocardio en personas con diabetes mellitus de la provincia de Granma. Métodos: se realizó un estudio transversal y descriptivo con 159 pacientes que ingresaron en la Unidad de Cuidados Intensivos Coronarios del Hospital "Carlos Manuel de Céspedes", de Ba...

  16. Renal posttransplant's vascular complications

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    Bašić Dragoslav

    2003-01-01

    Full Text Available INTRODUCTION Despite high graft and recipient survival figures worldwide today, a variety of technical complications can threaten the transplant in the postoperative period. Vascular complications are commonly related to technical problems in establishing vascular continuity or to damage that occurs during donor nephrectomy or preservation [13]. AIM The aim of the presenting study is to evaluate counts and rates of vascular complications after renal transplantation and to compare the outcome by donor type. MATERIAL AND METHODS A total of 463 kidneys (319 from living related donor LD and 144 from cadaveric donor - CD were transplanted during the period between June 1975 and December 1998 at the Urology & Nephrology Institute of Clinical Centre of Serbia in Belgrade. Average recipients' age was 33.7 years (15-54 in LD group and 39.8 (19-62 in CD group. Retrospectively, we analyzed medical records of all recipients. Statistical analysis is estimated using Hi-squared test and Fischer's test of exact probability. RESULTS Major vascular complications including vascular anastomosis thrombosis, internal iliac artery stenosis, internal iliac artery rupture obliterant vasculitis and external iliac vein rupture were analyzed. In 25 recipients (5.4% some of major vascular complications were detected. Among these cases, 22 of them were from CD group vs. three from LD group. Relative rate of these complications was higher in CD group vs. LD group (p<0.0001. Among these complications dominant one was vascular anastomosis thrombosis which occurred in 18 recipients (17 from CD vs. one from LD. Of these recipients 16 from CD lost the graft, while the rest of two (one from each group had lethal outcome. DISCUSSION Thrombosis of renal allograft vascular anastomosis site is the most severe complication following renal transplantation. In the literature, renal allograft thrombosis is reported with different incidence rates, from 0.5-4% [14, 15, 16]. Data from the

  17. Major Vascular Neurocognitive Disorder: A Reappraisal to Vascular Dementia

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    Emre Kumral

    2017-03-01

    Full Text Available Major vascular neurocognitive disorder (NCD is the second leading form of dementia after Alzheimer’s disease, accounting for 17-20% of all dementias. Vascular NCD is a progressive disease caused by reduced cerebral blood flow related to multiple large volume or lacunar infarcts that induce a sudden onset and stepwise decline in cognitive abilities. Despite its prevalence and clinical importance, there is still controversy in the terminology of vascular NCD. Only after the release of Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5 (2013 did the American Psychiatric Association define vascular dementia as “major vascular NCD”. This review includes an overview of risk factors, pathophysiology, types, diagnostic and clinical features of major vascular NCD, and current treatment options of vascular NCD regarding to DSM-5 criteria

  18. Miocárdio não compactado em paciente com infarto agudo do miocárdio Miocardio no compactado en paciente con infarto agudo de miocardio Noncompaction of the myocardium in a patient with acute myocardial infarction

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    Emanuel Correia

    2010-05-01

    Full Text Available Miocárdio não compactado (MCNC é uma cardiopatia congênita rara, resultado da falha na compactação do miocárdio, levando à persistência de trabeculações numerosas e profundas, comunicantes com a cavidade ventricular. Tem como principais manifestações clínicas: insuficiência cardíaca, eventos arrítmicos (supraventriculares ou ventriculares e episódios de embolismo arterial. Apresenta-se o caso de um cidadão brasileiro residente em Portugal internado por infarto agudo do miocárdio, do qual resultou disfunção sistólica severa do ventrículo esquerdo. No decorrer do estudo diagnosticou-se MCNC. Descreve-se a apresentação clínica, ecocardiográfica (bidimensional e tridimensional, imagem de ressonância magnética nuclear (RMN e ventriculografia. Discutem-se os critérios diagnósticos e opções terapêuticas.El miocardio no compactado (MCNC es una cardiopatía congénita rara, resultado de la falla en la compactación del miocardio, y ocasiona la persistencia de trabeculaciones numerosas y profundas, comunicantes con la cavidad ventricular. Tiene como principales manifestaciones clínicas: insuficiencia cardiaca, eventos arrítmicos (supraventriculares o ventriculares y episodios de embolismo arterial.Left-ventricular non-compaction (LVNC is a rare congenital cardiopathy, which results from the failure of the myocardial compaction process, leading to the persistence of numerous and deep trabeculations communicating with the ventricular cavity. Its main clinical manifestations are heart failure, arrhythmias (supraventricular or ventricular and episodes of arterial embolism. The present case reports on a Brazilian patient living in Portugal, who was hospitalized due to acute myocardial infarction, which resulted in severe LV systolic dysfunction. During the patient's assessment, LVNC was diagnosed. The clinical presentation is described, as well as the echocardiographic evaluation (two-dimensional and three

  19. Edema agudo hemorrágico da infância: relato de três casos Acute hemorrhagic edema of infancy: report of three cases

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    Paulo Sergio Emerich

    2011-12-01

    Full Text Available O Edema Agudo Hemorrágico da Infância é uma vasculite leucocitoclástica pouco frequente, que ocorre, quase exclusivamente, em crianças entre 4 meses e 2 anos de idade. Caracteriza-se, clinicamente, pela tríade febre, lesões purpúricas na face, pavilhões auriculares e extremidades e edema. Embora os achados cutâneos sejam dramáticos e de surgimento rápido, o prognóstico é favorável, com resolução espontânea dentro de 1 a 3 semanas. Descrevem-se três casos cujos achados clínicos e histopatológicos são característicos de edema agudo hemorrágico da infância.Acute Hemorrhagic Edema of Infancy is an infrequent leukocytoclastic vasculitis which occurs almost exclusively in children between 4 months and 2 years of age. It is clinically characterized by the triad fever, purpuric lesions on the face, auricular pinna and extremities, and edema. Although the cutaneous findings are dramatic and of rapid onset, the prognosis is favorable, with spontaneous resolution within 1 to 3 weeks. Three cases are described in which clinical and histopathological findings are characteristic of acute hemorrhagic edema of infancy.

  20. Trastornos psiquiátricos frecuentes post infarto agudo al miocardio y su relación pronóstica. Revisión de la literatura.

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    Manuel Mallol Simmonds

    2017-07-01

    Full Text Available La enfermedad cardiovascular es la principal causa de muerte a nivel mundial. De ella, el Infarto Agudo al Miocardio (IAM y el Accidente Cerebrovascular (AVC se encuentran fuertemente asociados a los cambios ambientales y sociales del último tiempo, tales como aumento de ingesta de comida rápida, sedentarismo, tabaquismo, entre otros. Algunos trastornos psiquiátricos que aparecen a corto y largo plazo posterior al evento coronario agudo tienen una implicancia directa en la morbimortalidad cardiovascular y global. De ellos, la depresión representa el trastorno psiquiátrico más frecuente, pudiendo encontrarse en 3 de cada 10 pacientes que tuvieron un IAM. La depresión aumenta las hospitalizaciones, disminuye la adherencia terapéutica y empeora el pronóstico cardiovascular a largo plazo.  La fisiopatología en lo anterior es explicada en parte por alteraciones en el eje neuroendocrino y la respuesta al estrés, mientras que otros fenómenos permanecen aún desconocidos. Dentro de otros trastornos psiquiátricos asociados a un IAM se encuentran el delirium, ansiedad y trastornos de la personalidad. En función de lo anterior, se hace necesaria la incorporación de un sistema continuo de monitoreo y apoyo en salud mental en este grupo de pacientes para mejorar tanto su pronóstico como la calidad de vida.

  1. Efectividad del modelo de cuidado de enfermería para la familia de paciente con infarto agudo al miocardio en la unidad de cuidados intensivos

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    David Jahel Garcia Avendaño

    2015-05-01

    Full Text Available Introducción: Este protocolo de investigación tiene la finalidad de intervenir con la familia y determinar la efectividad del Modelo de Cuidado de Enfermería para la Familia de Paciente con Infarto Agudo al Miocardio (IAM en la Unidad de Cuidados Intensivos (UCI. Materiales y Métodos: Estudio descriptivo de intervención familiar. Resultados y Discusión: El 100% de las familias respondió afirmativamente que la enfermera familiar les informo sobre los cuidados a realizar en la familia según las necesidades detectadas, estableció un plan de intervención en la familia mismo que cumplió y se interesó para que dentro de lo posible la estancia en la familia sea agradable. Conclusiones: Los resultados de esta investigación de intervención a las familias de paciente con IAM en las UCI aporta resultados que apoyan la importancia de aplicar un Modelo de Cuidado de Enfermería Familiar en dichas unidades.Cómo citar este artículo: García DJ, Estrada MC, Gallegos M, Antuna AB. Efectividad del modelo de cuidado de enfermería para la familia de paciente con infarto agudo al miocardio en la unidad de cuidados intensivos. Rev Cuid. 2015; 6(1: 923-31. http://dx.doi.org/10.15649/cuidarte.v6i1.166

  2. Investigación de vectores y reservorios en brote de Chagas agudo por posible transmisión oral en Aguachica, Cesar, Colombia

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    Hugo Soto

    2014-04-01

    Full Text Available Colombia tiene un registro de 11 casos de Chagas agudo y 80 casos por contaminación oral con Trypanosoma cruzi. Este trabajo analiza los hallazgos entomológicos y parasitológicos del brote de Aguachica, Cesar, en 2010. Un grupo interdisciplinario de profesionales de la salud y de universidades regionales realizó las pruebas de laboratorio a los pacientes y el estudio del foco de transmisión. Se detectaron 11 casos agudos de enfermedad de Chagas en una sola familia con vivienda sin triatominos domiciliados y, Rhodnius pallescens, Pantrongylus geniculatus, Eratyrus cuspidatus y dos Didelphis marsupialis infectados con T. cruzi en palmas de Attalea butyracea y Elaeis oleifera del área urbana de Aguachica. Se analiza la participación del R. pallescens y el rol de las palmas en el ciclo silvestre de T. cruzi y para la transmisión oral de la enfermedad de Chagas. Incursiones esporádicas de R. pallescens, P. geniculatus y E. cuspidatus silvestres desde palmas cercanas al domicilio humano pueden provocar brotes cada vez más frecuentes de Chagas oral.

  3. Plant Vascular Biology 2010

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Biao

    2014-11-17

    This grant supported the Second International Conference on Plant Vascular Biology (PVB 2010) held July 24-28, 2010 on the campus of Ohio State University, Columbus, Ohio. Biao Ding (Ohio State University; OSU) and David Hannapel (Iowa State University; ISU) served as co-chairs of this conference. Biao Ding served as the local organizer. PVB is defined broadly here to include studies on the biogenesis, structure and function of transport systems in plants, under conditions of normal plant growth and development as well as of plant interactions with pathogens. The transport systems cover broadly the xylem, phloem, plasmodesmata and vascular cell membranes. The PVB concept has emerged in recent years to emphasize the integrative nature of the transport systems and approaches to investigate them.

  4. Vascular cognitive impairment

    Directory of Open Access Journals (Sweden)

    N.V. Vakhnina

    2014-01-01

    Full Text Available Vascular pathology of the brain is the second most common cause of cognitive impairment after Alzheimer's disease. The article describes the modern concepts of etiology, pathogenetic mechanisms, clinical features and approaches to diagnosis and therapy of vascular cognitive impairment (VCI. Cerebrovascular accident, chronic cerebral circulatory insufficiency and their combination, sometimes in combination with a concomitant neurodegenerative process, are shown to be the major types of brain lesions leading to VCI. The clinical presentation of VCI is characterized by the neuropsychological status dominated by impairment of the executive frontal functions (planning, control, attention in combination with focal neurological symptoms. The diagnosis is based on comparing of the revealed neuropsychological and neurological features with neuroimaging data. Neurometabolic, acetylcholinergic, glutamatergic, and other vasoactive drugs and non-pharmacological methods are widely used to treat VCI. 

  5. Vascular Surgery and Robotics

    Directory of Open Access Journals (Sweden)

    Indrani Sen

    2016-01-01

    Full Text Available The application of robotics to Vascular surgery has not progressed as rapidly as of endovascular technology, but this is changing with the amalgamation of these two fields. The advent of Endovascular robotics is an exciting field which overcomes many of the limitations of endovascular therapy like vessel tortuosity and operator fatigue. This has much clinical appeal for the surgeon and hold significant promise of better patient outcomes. As with most newer technological advances, it is still limited by cost and availability. However, this field has seen some rapid progress in the last decade with the technology moving into the clinical realm. This review details the development of robotics, applications, outcomes, advantages, disadvantages and current advances focussing on Vascular and Endovascular robotics

  6. Vascular lesions following radiation

    International Nuclear Information System (INIS)

    Fajardo, L.F.; Berthrong, M.

    1988-01-01

    The special radiation sensitivity of the vascular system is mainly linked to that of endothelial cells, which are perhaps the most radiation-vulnerable elements of mesenchymal tissues. Within the vascular tree, radiation injures most often capillaries, sinusoids, and small arteries, in that order. Lesions of veins are observed less often, but in certain tissues the veins are regularly damaged (e.g., intestine) or are the most affected structures (i.e., liver). Large arteries do suffer the least; however, when significant damage does occur in an elastic artery (e.g., thrombosis or rupture), it tends to be clinically significant and even fatal. Although not always demonstrable in human tissues, radiation vasculopathy generally is dose and time dependent. Like other radiation-induced lesions, the morphology in the vessels is not specific, but it is characteristic enough to be often recognizable. Vascular injury, especially by therapeutic radiation is not just a morphologic marker. It is a mediator of tissue damage; perhaps the most consistent pathogenetic mechanism in delayed radiation injury

  7. Vascular lumen formation.

    Science.gov (United States)

    Lammert, Eckhard; Axnick, Jennifer

    2012-04-01

    The vascular system developed early in evolution. It is required in large multicellular organisms for the transport of nutrients, oxygen, and waste products to and from tissues. The vascular system is composed of hollow tubes, which have a high level of complexity in vertebrates. Vasculogenesis describes the de novo formation of blood vessels, e.g., aorta formation in vertebrate embryogenesis. In contrast, angiogenesis is the formation of blood vessels from preexisting ones, e.g., sprouting of intersomitic blood vessels from the aorta. Importantly, the lumen of all blood vessels in vertebrates is lined and formed by endothelial cells. In both vasculogenesis and angiogenesis, lumen formation takes place in a cord of endothelial cells. It involves a complex molecular mechanism composed of endothelial cell repulsion at the cell-cell contacts within the endothelial cell cords, junctional rearrangement, and endothelial cell shape change. As the vascular system also participates in the course of many diseases, such as cancer, stroke, and myocardial infarction, it is important to understand and make use of the molecular mechanisms of blood vessel formation to better understand and manipulate the pathomechanisms involved.

  8. Pulmonary vascular imaging

    International Nuclear Information System (INIS)

    Fedullo, P.F.; Shure, D.

    1987-01-01

    A wide range of pulmonary vascular imaging techniques are available for the diagnostic evaluation of patients with suspected pulmonary vascular disease. The characteristics of any ideal technique would include high sensitivity and specificity, safety, simplicity, and sequential applicability. To date, no single technique meets these ideal characteristics. Conventional pulmonary angiography remains the gold standard for the diagnosis of acute thromboembolic disease despite the introduction of newer techniques such as digital subtraction angiography and magnetic resonance imaging. Improved noninvasive lower extremity venous testing methods, particularly impedance plethysmography, and ventilation-perfusion scanning can play significant roles in the noninvasive diagnosis of acute pulmonary emboli when properly applied. Ventilation-perfusion scanning may also be useful as a screening test to differentiate possible primary pulmonary hypertension from chronic thromboembolic pulmonary hypertension. And, finally, angioscopy may be a useful adjunctive technique to detect chronic thromboembolic disease and determine operability. Optimal clinical decision-making, however, will continue to require the proper interpretation of adjunctive information obtained from the less-invasive techniques, applied with an understanding of the natural history of the various forms of pulmonary vascular disease and with a knowledge of the capabilities and shortcomings of the individual techniques

  9. Percepción de autoeficacia vs. rechazo del uso del condón en las prácticas sexuales de mujeres y hombres jóvenes/Self-efficacy perception vs. rejection of condom use in the sexual practices of young women and men.

    OpenAIRE

    J. Isaac Uribe Alvarado; Manuel E. Riaño Garzón; Nidia J. Bonilla Cruz; Sandra M. Carrillo Sierra; Yurley Hernández Peña; Marly Johana Bahamón Muñetón

    2017-01-01

    Resumen En las relaciones sexuales de jóvenes, las variables asociadas al uso del condón son diversas y comúnmente se presentan con otras variables que, a su vez, se asocian con la práctica sexual desprotegida. Los objetivos de este estudio consistieron en determinar en qué medida la percepción de autoeficacia, la baja percepción de riesgo y el rechazo del uso del condón se relacionan con el uso del condón en las relaciones sexuales de jóvenes colombianos. Participaron en él 308 estu diantes ...

  10. Diseño de una máquina para la producción de espacatos, a partir del uso de adoquines de rechazo, en una fábrica de productos de arcilla de la ciudad de Guayaquil

    OpenAIRE

    Ponce Gaibor, Luis Eduardo

    2017-01-01

    La fábrica de productos de arcilla objeto de estudio muestra un elevado costo de almacenamiento debido a la presencia de un alto inventario de adoquines que no tienen salida al mercado dado el incumplimiento de ciertas conformidades de calidad. En este contexto, este trabajo presenta una propuesta que parte de la utilización de los adoquines de rechazo para transformarlos en espacatos, que es un elemento decorativo muy usado en la actualidad. El proyecto buscó diseñar una máquina que permita ...

  11. Calidad de la atención médica a pacientes con infarto agudo del miocardio. Cienfuegos 2011

    Directory of Open Access Journals (Sweden)

    Hilda María Delgado Acosta

    2013-09-01

    Full Text Available Fundamento: la evaluación constituye una herramienta para mejorar la calidad de la atención a los pacientes. Objetivo: evaluar la calidad de la atención médica a pacientes con infarto agudo de miocardio admitidos en el Hospital General Universitario Dr. Gustavo Aldereguía Lima de Cienfuegos en junio de 2011. Métodos: se realizó una investigación de sistemas y servicios de salud en la que se analizaron como variables: las relacionadas con estructura (recursos humanos y materiales, procesos (cumplimiento de los protocolos establecidos para la atención y resultados (impacto en la mortalidad. Se aplicó un formulario a los 22 pacientes estudiados, se utilizó una guía de observación que evaluó la existencia de recursos humanos y materiales necesarios para la atención en el hospital. Los datos se procesaron en el programa SPSS 15,0 y se expresaron en números absolutos y porcientos. Resultados: en la dimensión estructura no se encontraron carencias de recursos materiales esenciales para la atención, hubo dificultades con la cobertura de enfermería en el Servicio de Cardiología. En la atención prehospitalaria hubo demora en acudir a consulta, dificultades en la prescripción de aspirina y la no realización de trombólisis. En la posthospitalaria se centraron en la rehabilitación y trabajo en la modificación de los factores de riesgo asociados. En el hospital hubo dificultades en la realización de las pruebas ergométricas al alta y en la remisión para la rehabilitación en el Área de Salud. Conclusiones: existen dificultades en la calidad de atención a los pacientes, dificultades que se hacen más evidentes en la Atención Primaria de Salud.

  12. 123. Intervención quirúrgica urgente en paciente varón joven con angiosarcoma primario cardíaco con diagnóstico de tromboembolismo pulmonar agudo

    Directory of Open Access Journals (Sweden)

    N. Miranda

    2012-04-01

    Conclusiones: Son infrecuentes los casos de sarcoma cardíaco primario publicados en la bibliografía y muy pocos los que han cursado como tromboembolismo pulmonar agudo. Este caso ilustra la enorme dificultad que presentan para un diagnóstico y tratamiento precoz que ofrezca unas mínimas expectativas de vida a medio plazo.

  13. Prevalencia y curso clínico de la infección por dengue en adultos mayores con cuadro febril agudo en un hospital de alta complejidad en Cali, Colombia

    Directory of Open Access Journals (Sweden)

    Fernando Rosso

    2016-08-01

    Conclusión. La infección por dengue fue frecuente en adultos mayores como causa de síndrome febril agudo. Una importante proporción requirió hospitalización y presentó complicaciones, sin embargo, el manejo adecuado evitó los casos fatales.

  14. La supuesta asociación entre la vacuna triple vírica y el autismo y el rechazo a la vacunación The putative link between the MMR vaccine and autism and refusal to vaccinate

    Directory of Open Access Journals (Sweden)

    Andreu Segura Benedicto

    2012-08-01

    Full Text Available La publicación del artículo de Wakefield et al. en The Lancet desencadenó una reacción de rechazo a la vacuna triple vírica, a pesar de que se trataba solo de una serie de casos y la asociación entre la vacunación y el autismo hubiera podido muy bien ser anecdótica. Sin embargo, más tarde se comprobó que tal asociación era espuria, debido no solo a sesgos ocultados sino también a alteraciones interesadas de los datos y a otros comportamientos impropios de dos de los autores que por ello fueron expulsados del colegio de médicos. Finalmente el artículo fue retirado de la revista. Este episodio invita a reflexionar sobre la credibilidad y la confianza que merecen las autoridades y los profesionales a la población, así como sobre los recelos que pueden plantearse cuando se producen potenciales conflictos de intereses entre los profesionales, la industria, las revistas y la población. Un aspecto de particular interés es el de las expectativas distorsionadas sobre las posibilidades de las intervenciones sanitarias, incluida la vacunación, especialmente respecto de la dimensión individual y la colectiva de la prevención.The paper of Wakefield et al. in The Lancet, triggered a negative reaction to the MMR vaccine, even though it was just a series of cases and the association between vaccination and autism could well be anecdotal. However, it was found that this association was spurious, not only because of hidden biases but also to alterations of the data and other improper behavior of the two authors that they were expelled from medical council. Finally, the article was removed from the magazine. This episode invites to think about the credibility and trust in the authorities and professionals to the population, as well as the suspicions that may arise when there are potential conflicts of interest among professionals, industry magazines and the population. A special area of interest is on the distorted expectations of health

  15. Vascular remodeling and mineralocorticoids.

    Science.gov (United States)

    Weber, K T; Sun, Y; Campbell, S E; Slight, S H; Ganjam, V K

    1995-01-01

    Circulating mineralocorticoid hormones are so named because of their important homeostatic properties that regulate salt and water balance via their action on epithelial cells. A broader range of functions in nonclassic target cellular sites has been proposed for these steroids and includes their contribution to wound healing following injury. A chronic, inappropriate (relative to intravascular volume and dietary sodium intake) elevation of these circulating hormones evokes a wound healing response in the absence of tissue injury--a wound healing response gone awry. The adverse remodeling of vascularized tissues seen in association with chronic mineralocorticoid excess is the focus of this review.

  16. Características clínico epidemiológicas de pacientes con infarto miocárdico agudo

    Directory of Open Access Journals (Sweden)

    Omar Lóriga García

    2013-12-01

    Full Text Available Introducción: la cardiopatía isquémica, y entre estas el Infarto Agudo del Miocardio con elevación del segmento ST, es la primera causa de muerte a nivel mundial. Objetivo: describir las características clínico epidemiológicas de pacientes con infarto agudo del miocardio de la unidad de cuidados coronarios del Hospital General Docente Abel Santamaría Cuadrado de Pinar del Río, en 2011 y 2012. Material y Método: estudio observacional, descriptivo, retrospectivo transversal; universo 644 pacientes ingresados con elevación del ST. Los datos se tomaron de las historias clínicas. Resultados: 62% tenían entre 60- 79 años. 84.5% de los pacientes entre 30 y 49 años eran hombres. 81,6% fumaba y el 45,5% era diabético. La localización topográfica del infarto fue: inferior el 70,8%, anterior el 22,9% y anterior extensa el 6,2% de los pacientes. Como complicación, la arritmia se presentó en el 34% de los pacientes, la insuficiencia cardiaca en el 14,9% y la muerte en 7,7%. El 68,5% de los pacientes con arritmias tuvo fibrilación auricular. La trombolisis se empleó en el 55,2% de los pacientes apareciendo, entre las complicaciones, la hipotensión en el 30,7%. Conclusiones: el infarto miocárdico agudo fue más frecuente en pacientes de mayor edad, siendo antes de los 50 años cinco veces más frecuente entre los hombres. Los factores de riesgo más representados fueron el hábito de fumar y la diabetes mellitus. La localización más frecuente fue la inferior y la complicación las arritmias y dentro de estas la fibrilación auricular. La trombolisis se complica principalmente con hipotensión, pudiendo ser más empleada.

  17. Perfil etiológico del síndrome febril icterohemorrágico agudo y síndrome febril ictérico agudo en los valles del Apurímac, Quillabamba, Chanchamayo y Alto Huallaga, Perú, 1999-2000.

    Directory of Open Access Journals (Sweden)

    2003-07-01

    Full Text Available Objetivos: Conocer el perfil etiológico del síndrome febril hemorrágico agudo (SFHA y del síndrome febril ictérico agudo (SFIA en los valles del Río Apurímac (Ayacucho, Quillabamba (Cusco, Chanchamayo (Junín y Alto Huallaga (Huánuco. Materiales y métodos: Estudio longitudinal descriptivo realizado entre junio de 1999 y mayo de 2000, en 146 establecimientos de salud de los cuatro valles involucrados. Fueron incluidos pacientes que cumplieron con las definiciones de caso para la vigilancia del síndrome febril hemorrágico agudo y el síndrome febril ictérico agudo. Las muestras obtenidas se procesaron por ELISA IgM de captura para fiebre amarilla; IgM anti-HBc ELISA y HBsAg ELISA para hepatitis B; Ig anti-VHD ELISA para hepatitis D; e IgM ELISA para leptospirosis. Resultados: Fueron incluidos 63 casos: 98,4% con SFIA y 1,6% con SFHA. La letalidad fue de 16% y el tiempo entre inicio de síntomas y la obtención de la muestra de 7,2 ±5,1 días. Los casos que tuvieron confirmación diagnóstica fueron 31 (49,2%, hepatitis B (23,8%, hepatitis D (15,6%, fiebre amarilla (4,8% y leptospirosis (4,8%. Cusco tuvo el mayor porcentaje de casos confirmados por laboratorio, siendo la mayoría hepatitis B y D. Conclusiones: El estudio de la etiología de SFIA y SFHA ha permitido identificar tres brotes de fiebre amarilla en Cusco, Junín y Huánuco, y conocer la importancia de la hepatitis B, D y leptospirosis en el diagnóstico diferencial de estos síndromes. Si bien las definiciones usadas apuntan a detectar enfermedades severas, la vigilancia de ambos síndromes es complementaria y totalmente compatible con los sistemas de enfermedad específica y por el laboratorio.

  18. Interventional vascular radiology

    International Nuclear Information System (INIS)

    Yune, H.Y.

    1984-01-01

    The papers published during this past year in the area of interventional vascular radiology presented some useful modifications and further experiences both in the area of thromboembolic therapy and in dilation and thrombolysis, but no new techniques. As an introductory subject, an excellent monograph reviewing the current spectrum of pharmacoangiography was presented in Radiographics. Although the presented material is primarily in diagnostic application of various pharmacologic agents used today to facilitate demonstration of certain diagnostic criteria of various disease processes, both vasodilatory and vasoconstrictive reaction to these agents are widely used in various therapeutic vascular procedures. This monograph should be reviewed by every angiographer whether or not he or she performs interventional procedures, and it would be very convenient to have this table available in the angiography suite. In a related subject, Bookstein and co-workers have written an excellent review concerning pharmacologic manipulations of various blood coagulative parameters during angiography. Understanding the proper method of manipulation of the bloodclotting factors during angiography, and especially during interventional angiography, is extremely important. Particularly, the method of manipulating the coagulation with the use of heparin and protamine and modification of the platelet activity by using aspirin and dipyridamole are succinctly reviewed. The systemic and selective thrombolytic activities of streptokianse are also discussed

  19. Vascular dysfunction in preeclampsia.

    Science.gov (United States)

    Brennan, Lesley J; Morton, Jude S; Davidge, Sandra T

    2014-01-01

    Preeclampsia is a complex disorder which affects an estimated 5% of all pregnancies worldwide. It is diagnosed by hypertension in the presence of proteinuria after the 20th week of pregnancy and is a prominent cause of maternal morbidity and mortality. As delivery is currently the only known treatment, preeclampsia is also a leading cause of preterm delivery. Preeclampsia is associated with maternal vascular dysfunction, leading to serious cardiovascular risk both during and following pregnancy. Endothelial dysfunction, resulting in increased peripheral resistance, is an integral part of the maternal syndrome. While the cause of preeclampsia remains unknown, placental ischemia resulting from aberrant placentation is a fundamental characteristic of the disorder. Poor placentation is believed to stimulate the release of a number of factors including pro- and antiangiogenic factors and inflammatory activators into the maternal systemic circulation. These factors are critical mediators of vascular function and impact the endothelium in distinctive ways, including enhanced endothelial oxidative stress. The mechanisms of action and the consequences on the maternal vasculature will be discussed in this review. © 2013 John Wiley & Sons Ltd.

  20. Vascular Remodeling in Experimental Hypertension

    Directory of Open Access Journals (Sweden)

    Norma R. Risler

    2005-01-01

    Full Text Available The basic hemodynamic abnormality in hypertension is an increased peripheral resistance that is due mainly to a decreased vascular lumen derived from structural changes in the small arteries wall, named (as a whole vascular remodeling. The vascular wall is an active, flexible, and integrated organ made up of cellular (endothelial cells, smooth muscle cells, adventitia cells, and fibroblasts and noncellular (extracellular matrix components, which in a dynamic way change shape or number, or reorganize in response to physiological and pathological stimuli, maintaining the integrity of the vessel wall in physiological conditions or participating in the vascular changes in cardiovascular diseases such as hypertension. Research focused on new signaling pathways and molecules that can participate in the mechanisms of vascular remodeling has provided evidence showing that vascular structure is not only affected by blood pressure, but also by mechanisms that are independent of the increased pressure. This review will provide an overview of the evidence, explaining some of the pathophysiologic mechanisms participating in the development of the vascular remodeling, in experimental models of hypertension, with special reference to the findings in spontaneously hypertensive rats as a model of essential hypertension, and in fructose-fed rats as a model of secondary hypertension, in the context of the metabolic syndrome. The understanding of the mechanisms producing the vascular alterations will allow the development of novel pharmacological tools for vascular protection in hypertensive disease.

  1. Vascular pattern formation in plants.

    Science.gov (United States)

    Scarpella, Enrico; Helariutta, Ykä

    2010-01-01

    Reticulate tissue systems exist in most multicellular organisms, and the principles underlying the formation of cellular networks have fascinated philosophers, mathematicians, and biologists for centuries. In particular, the beautiful and varied arrangements of vascular tissues in plants have intrigued mankind since antiquity, yet the organizing signals have remained elusive. Plant vascular tissues form systems of interconnected cell files throughout the plant body. Vascular cells are aligned with one another along continuous lines, and vascular tissues differentiate at reproducible positions within organ environments. However, neither the precise path of vascular differentiation nor the exact geometry of vascular networks is fixed or immutable. Several recent advances converge to reconcile the seemingly conflicting predictability and plasticity of vascular tissue patterns. A control mechanism in which an apical-basal flow of signal establishes a basic coordinate system for body axis formation and vascular strand differentiation, and in which a superimposed level of radial organizing cues elaborates cell patterns, would generate a reproducible tissue configuration in the context of an underlying robust, self-organizing structure, and account for the simultaneous regularity and flexibility of vascular tissue patterns. Copyright 2010 Elsevier Inc. All rights reserved.

  2. Additive Manufacturing of Vascular Grafts and Vascularized Tissue Constructs.

    Science.gov (United States)

    Elomaa, Laura; Yang, Yunzhi Peter

    2017-10-01

    There is a great need for engineered vascular grafts among patients with cardiovascular diseases who are in need of bypass therapy and lack autologous healthy blood vessels. In addition, because of the severe worldwide shortage of organ donors, there is an increasing need for engineered vascularized tissue constructs as an alternative to organ transplants. Additive manufacturing (AM) offers great advantages and flexibility of fabrication of cell-laden, multimaterial, and anatomically shaped vascular grafts and vascularized tissue constructs. Various inkjet-, extrusion-, and photocrosslinking-based AM techniques have been applied to the fabrication of both self-standing vascular grafts and porous, vascularized tissue constructs. This review discusses the state-of-the-art research on the use of AM for vascular applications and the key criteria for biomaterials in the AM of both acellular and cellular constructs. We envision that new smart printing materials that can adapt to their environment and encourage rapid endothelialization and remodeling will be the key factor in the future for the successful AM of personalized and dynamic vascular tissue applications.

  3. Hematoma subdural agudo traumático: estudo de 110 pacientes Acute traumatic subdural haematomas: study of 110 cases

    Directory of Open Access Journals (Sweden)

    Nicandro de Figueiredo Neto

    1996-06-01

    Full Text Available Apresentamos uma série consecutiva de 110 pacientes com hematoma subdural agudo traumático (HSDA admitidos no serviço de emergência do HBDF no período de 1°-janeiro a 1°-dezembro-1994. Todos os pacientes foram atendidos de acordo com o mesmo protocolo. Houve predominância do sexo masculino (79%, com idade variando entre 14 e 70 anos, sendo os atropelamentos (34% e os acidentes automobilísticos (20% as causas mais comuns. A maioria dos pacientes (85,7% foi admitida muito grave, com 8 pontos ou menos na Escala de Coma Glasgow (ECG, o que influenciou diretamente na mortalidade. A tomografia computadorizada de crânio foi o exame diagnóstico de escolha que mostrou serem as contusões e o inchaço cerebral ("swelling" as lesões intracranianas associadas mais freqüentes. A cirurgia foi realizada em 45,1% dos pacientes, e, em sua maioria, através de craniotomia fronto-têmporo-parietal ampla, com drenagem do hematoma, seguida de plástica da dura-mater. Em 54,9% as condições clínicas não permitiram a realização da cirurgia; neste grupo, cerca de 69,6% estavam em coma profundo à admissão, com 3 pontos na ECG. A letalidade cirúrgica foi de 61,2% e esteve diretamente relacionada à condição clínica inicial e à idade do paciente. A letalidade, incluindo todos os pacientes cirúrgicos e não cirúrgicos com HSDA, mesmo aqueles admitidos já com sinais de falência de tronco cerebral, foi de 79,5%. Além destes pacientes que faleceram, cerca de 7% evoluíram sem seqüelas ou com seqüelas mínimas; outros 11,4% com seqüelas de moderadas a paves e 2,1 % permaneceram em estado vegetativo persistente. Nossos dados estão de acordo com os da literatura no que se refere a elevada taxa de morbidade e mortalidade dos pacientes com HSDA.We report a series of 110 patients with acute traumatic subdural hematoma (ASDH admitted at HBDF emergency within 1994 (January Is1 to December PJ.All patients were treated according to the same protocol

  4. Años de vida perdidos por infarto agudo de miocardio en la Argentina entre 1991 y 2005

    Directory of Open Access Journals (Sweden)

    Fernando Botto

    2008-01-01

    Full Text Available IntroducciónLos años potenciales de vida perdidos (APVP son uno de los indicadores utilizados para determinar las muertes tempranas. A diferencia de las tasas de mortalidad, crudas y ajustadas por edad, este indicador, que cuantifica los años que teóricamente una persona deja de vivir si la muerte se presenta en forma prematura (o sea antes de cumplir su esperanza de vida, da una visión más amplia de la importancia relativa que tienen las causas más relevantes de mortalidad prematura, por lo que su uso se justifica en la planificación y en la definición de prioridades en salud.ObjetivosDescribir la evolución de la mortalidad por infarto agudo de miocardio (IAM en términos de tasas de mortalidad (TM y de años potenciales de vida perdidos (APVP para el período 1991-2005, identificar diferencias en relación con el sexo y comparar la media de APVP por muerto (MAPVP entre los registros SAC y los de la Dirección de Estadística e Información de Salud del Ministerio de Salud y Acción Social (DEIS.Material y métodosLas defunciones por IAM, distribuidas por edad y sexo, se obtuvieron de la DEIS y de los registros SAC. Los APVP se calcularon según la fórmula de Romeder y Mc Whinnie y también sobre la base de la esperanza de vida al nacer, además de la MAPVP con su intervalo de confianza del 95%.ResultadosLa TM por IAM según la DEIS descendió de 50 en 1991 a 38 por 100.000 habitantes en 2005 (pendiente [slope] -3,7; p < 0,001. La tasa de APVP disminuyó de 516 a 314 años por 100.000 en igual período. A nivel nacional, la MAPVP fue de 11,3 (11,1-11,5, 11,4 (11,2- 11,6, 11,5 (11,3-11,7, 11,1 (10,8-11,3 para 1991, 1996, 2000 y 2005, respectivamente (pendiente 0,0. Se observaron resultados similares a los de la SAC -10,8 (8,22-13,5, 10,4 (6,86- 14,0, 7,50 (4,67-10,3, 14,0 (10,3-17,7- para los años mencionados (pendiente +0,67. En relación con el sexo tampoco hubo diferencias, excepto para el caso de las mujeres en el año 2000 (p

  5. Edad avanzada y factores de riesgo para infarto agudo de miocardio Risk factors for acute myocardial infarction in the elderly

    Directory of Open Access Journals (Sweden)

    M. A. Ciruzzi

    2002-12-01

    Full Text Available Este estudio caso-control analizó en los sujetos añosos el rol de los factores de riesgo coronario en el desarrollo del infarto agudo de miocardio (IAM, estableció la naturaleza de esta asociación y el grado de riesgo. Los datos fueron obtenidos en una investigación que incluyó 1060 casos y 1071 controles, realizada en 35 unidades coronarias de centros médicos de Argentina entre noviembre de 1991 y agosto de 1994. Nuestro análisis se basó en la información de los sujetos mayores de 65 años. Los casos fueron 427 pacientes con un primer IAM. Los controles fueron 396 sujetos sin evidencias clinicas de enfermedad cardiovascular, seleccionados en los mismos centros que los casos. Los Odds Ratios (OR y su intervalo de confianza del 95% (IC 95% se obtuvieron mediante un análisis de regresión logística, incluyendo variables como la edad, educación, clase social, tabaquismo, antecedente de diabetes o hipertensión arterial, índice de masa corporal e historia familiar de enfermedad coronaria. Los factores de riesgo relacionados independientemente con IAM fueron los siguientes: hipercolesterolemia (colesterol sérico > 240 mg/dl: OR=1.76 (IC 95%: 1.25-2.49, tabaquismo: OR=1.6 (IC 95%: 1.06-2.4, hipertensión arterial: OR=2.05 (IC 95%: 1.51-2.73, diabetes OR=1.71 (IC 95%: 1.12-2.70, historia de un familiar con enfermedad coronaria: OR=1.36 (IC 95%: 0.93-1.97 y de dos o más familiares: OR=2.63 (IC 95%: 1.21-5.71. Este estudio, confirma en los sujetos de edad avanzada la importancia de la hipercolesterolemia, del tabaquismo, la hipertesión arterial, la diabetes y la historia familiar de enfermedad coronaria como factores de riesgo de IAMThis case-control study, analized the role of coronary risk factors in acute myocardial infarction (AMI in the elderly, and established the nature of this association and the degree of risk. Data were derived from an investigation (1060 cases and 1071 controls conducted in 35 coronary care units from clinical

  6. Edema agudo hemorrágico da infância: relato de três casos Acute hemorrhagic edema of infancy: report of three cases

    OpenAIRE

    Paulo Sergio Emerich; Patricia Almeida Prebianchi; Luciene Lage da Motta; Elton Almeida Lucas; Leonardo Mello Ferreira

    2011-01-01

    O Edema Agudo Hemorrágico da Infância é uma vasculite leucocitoclástica pouco frequente, que ocorre, quase exclusivamente, em crianças entre 4 meses e 2 anos de idade. Caracteriza-se, clinicamente, pela tríade febre, lesões purpúricas na face, pavilhões auriculares e extremidades e edema. Embora os achados cutâneos sejam dramáticos e de surgimento rápido, o prognóstico é favorável, com resolução espontânea dentro de 1 a 3 semanas. Descrevem-se três casos cujos achados clínicos e histopatológi...

  7. CARACTERIZACIÓN DEL SÍNDROME CORONARIO AGUDO SIN ELEVACIÓN DEL ST EN EL CENTRO DIAGNÓSTICO INTEGRAL

    Directory of Open Access Journals (Sweden)

    Rider Piñeiro López

    2012-03-01

    Full Text Available Resumen Introducción y objetivos: El síndrome coronario agudo presenta una elevada incidencia en el cuadro de morbilidad y mortalidad de los países del mundo desarrollado. El objetivo de esta investigación fue determinar la morbilidad por síndrome coronario agudo y su relación con algunas variables. Método: Se realizó un estudio epidemiológico, observacional, descriptivo, en 30 pacientes con el diagnóstico de síndrome coronario agudo sin elevación del ST, atendidos en la Unidad de Terapia Intensiva del Centro Diagnóstico Integral “José Gregorio Hernández”, municipio Ortiz, estado Guárico, República Bolivariana de Venezuela; en el período del 1 de enero al 31 de diciembre de 2007. Resultados: La angina inestable fue la enfermedad más frecuente (80,0 % en estos pacientes. Predominaron los mayores de 49 años (80 %, del sexo femenino (63,3 %, color negro de piel, procedencia urbana y escolaridad secundaria. El tabaquismo constituyó el factor de riesgo más frecuente (56,6 %, seguido de hipertensión arterial (43,3 % y obesidad (26,6 %. Las arritmias y el fallo de bomba fueron frecuentes en pacientes con infarto; el dolor precordial mantenido, en enfermos con angina inestable. Hubo un fallecido por infarto agudo de miocardio, con más de sesenta años y menos de tres días de estadía. Conclusiones: Predominó la angina inestable, y los factores de riesgo más frecuentemente asociados, fueron la hipertensión arterial y el hábito de fumar. Abstract Introduction and objectives: Acute coronary syndrome has a high impact on morbidity and mortality rates of the developed world. The objective of this research was to determine the morbidity for acute coronary syndrome and its relation to some variables. Method: An epidemiological, observational, descriptive study was performed in 30 patients with the diagnosis of acute coronary syndrome without ST elevation, treated at the Intensive Care Unit of the Integral Diagnostic Center "Jos

  8. Infarto agudo del miocardio en los centros diagnósticos integrales de Vargas, Venezuela Myocardial acute infarction in integral diagnosis centers of Vargas, Venezuela

    Directory of Open Access Journals (Sweden)

    Ana Rosa Jorna Calixto

    2010-12-01

    Full Text Available INTRODUCCIÓN: el infarto agudo del miocardio constituyó más del 12 % de los fallecimientos por cardiopatía isquémica en Venezuela en 2006, sin evidenciarse disminución en la mortalidad a pesar del mejoramiento tecnológico de los servicios de urgencias. OBJETIVO: caracterizar su comportamiento en los centros de diagnóstico integrales del Estado de Vargas, en el período comprendido de junio de 2006 a junio de 2009. MÉTODOS: se realizó un estudio descriptivo, retrospectivo para caracterizar el comportamiento del infarto agudo del miocardio en los servicios de urgencia y emergencia de los centros de diagnóstico integrales utilizando las estadísticas de la Misión Barrio Adentro. RESULTADOS: fueron atendidos 186 pacientes por infarto agudo del miocardio, predominaron los ingresos en la terapia intensiva (2,4 % sobre los servicios de hospitalización. Los fallecidos por esta causa fueron 35 personas, 17,1 % del total de fallecidos. Fueron trombolizados el 39,2 %, con el mayor número alcanzado en el 2008 con 51,2 %. La letalidad por infarto agudo del miocardio osciló entre tasas de 17,3 y 20 por cada 100 pacientes vistos. La tasa de mortalidad bruta fue de 9,58 x 100 000 habitantes. CONCLUSIONES: el número de casos atendidos por infarto tuvo un comportamiento ascendente de manera estable, representaron el 0,7 % del total de ingresos en estos centros, con predominio de los ingresos en la terapia intensiva sobre los servicios de hospitalización. Se le aplicó el tratamiento trombolítico con estreptoquinasa recombinante a un por ciento importante de enfermos. En los servicios de hospitalización fue superior la letalidad por esta causa. No disminuyó el riesgo de morir para los pacientes con esta enfermedad y la mortalidad general en el período estudiado fue de 35 pacientes para una tasa de 9,58 × 100 000 habitantes.INTRODUCTION: the acute myocardial infarction was over the 12 % of deceased from ischemic heart disease in Venezuela in

  9. Neumonía eosinofílica: presentación de dos casos, agudo y crónico

    Directory of Open Access Journals (Sweden)

    Oscar Pamo Reyna

    2007-01-01

    Full Text Available Se presenta dos casos de neumonía eosinofílica idiopática, uno crónico y otro agudo. En el caso clínico 1 se realizó una confirmación anatomopatológica de neumonía eosinofílica idiopática y en el caso clínico 2 se tuvo una neumonia eosinofílica aguda probable. Ambos presentaron tos, fiebre y disnea. El estudio radiográfico reveló lesiones alveolares bilaterales con tendencia a la consolidación. La marcada eosinofilia en sangre periférica fue un dato resaltante que facilitó el diagnóstico. Ambos casos tuvieron muy buena respuesta a la corticoterapia.(Rev Med Hered 2007;18:39-44.

  10. Correlación clínica, laparoscópica e histológica en el abdomen agudo

    Directory of Open Access Journals (Sweden)

    María Elena Trujillo Toledo

    1995-12-01

    Full Text Available Se presentan 132 pacientes con diagnóstico clínico de abdomen agudo durante 1991 a 1993, a quienes se les realizó laparoscopia de urgencia. Las afecciones más frecuentes en que se realizó laparoscopia fueron: apendicitis aguda y las enfermedades ginecológicas. La efectividad de la laparoscopia en relación con el resultado histológico fue del 97,1 %, y no coincidió en 3 pacientes con diagnóstico laparoscópico de apendicitis aguda, hematosalpinx derecho y peritonitis pélvica, sin especificar factor causal. En el 19,6 % la conclusión laparoscópica evitó una intervención quirúrgica

  11. Abdome agudo em pós-operatório tardio de apendicite aguda: pode não ser bridas

    Directory of Open Access Journals (Sweden)

    Bruno Castro Fernandes

    2014-10-01

    Full Text Available As ressecções intestinais em países desenvolvidos ocorrem devido às malformações congênitas. Em países em desenvolvimento essas resseções ocorrem por causas potencialmente evitáveis, como invaginação intestinal irredutível, trauma abdominal fechado, volvo de jejuno-íleo, enterocolite necrosante, hérnia inguinal estrangulada e obstrução por bridas pós-operatórias. O volvo intestinal na infância é raro e geralmente de causas iatrogênicas causado, por exemplo, pela presença de grampos soltos a cavidade intestinal após apendicectomia laparoscópica. O volvo de jejuno-íleo pode ser secundário à isquemia nos casos de gastrosquise tratadas com silo ou mesmo pela colocação de banda gástrica pós-laparoscopia, ou ainda pela presença de lipoma mesentérico. Não foi identificado trabalho na literatura recente sobre volvo jejuno-íleo e isquemia e necrose de segmento de alça intestinal. O autores relatam um caso de abdome agudo obstrutivo em criança de 6 anos, em pós-operatório tardio (4 anos de apendicectomia aberta e cuja ressecção de segmento de Alça intestinal foi necessária nas duas oportunidades mas por motivos diferentes. Situações adversas em abdome agudo pós-operatório podem não ser por aderências intestinais, mas por situações mais graves e o cirurgião deve estar preparado para corrigir sua tática operatória.

  12. Etiología del síndrome febril agudo en la provincia de Jaén, Perú 2004-2005

    Directory of Open Access Journals (Sweden)

    Lucinda Troyes R

    2006-01-01

    Full Text Available Objetivo: Conocer a tiología el Síndrome febril agudo en nacientes que acudieron a tres establecimientos de salud de la provincia de Jaén entre mayo de 2004 y abril de 2005. Materiales y métodos: Estudio descriptivo prospectivo realizado en tres establecimientos de salud: Hospital General de Jaén, Hospital de Apoyo Bellavista y Centro de Salud Morro Solar. Se incluyeron pacientes entre 5 y 65 años con fiebre de menos de ocho días de evolución y sin foco infeccioso aparente. Inicialmente se les realizó gota gruesa para malaria y frotis sanguíneo para Bartonelosis; de los casos negativos se obtuvo una segunda muestra de sangre para la búsqueda de ELISA IgM y microaglutinación para el diagnóstico de leptospirosis, ELISA IgM para dengue, Mayaro, Oropuche y encefalitis equina venezolana, e inmunofluorescencia indirecta para Rickettsiosis. Resultados: De 1039 febriles incluidos, se determinó la etiología en 680 (65,4%casos, malaria por P.falciparum 312 (30,0%, leptospirosis 115 (11,1%, dengue 105 (10,1%, malaria por P. vivax 76 (7,3%,leptospirosis más dengue 30 (2,9%, Rickettsiosis 15 (1,4%,Bartonelosis 17 (1,6%,leptospirosis más Rickettsiosis 7 (0,7%, y leptospirosis, dengue más Rickettsiosis 3 (0,3%. Los serovares de Leptospira más frecuentes fueron varilla (35,7%y bratislava (32,5%. Conclusión: La malaria es la principal causa de síndrome febril agudo en Jaén, se destaca la presencia de la leptospirosis como segunda causa,por delante del dengue; es necesario considerar dentro del diagnóstico diferencial Rickettsiosis y Bartonelosis.

  13. Cardiac and vascular malformations

    International Nuclear Information System (INIS)

    Ley, S.; Ley-Zaporozhan, J.

    2015-01-01

    Malformations of the heart and great vessels show a high degree of variation. There are numerous variants and defects with only few clinical manifestations and are only detected by chance, such as a persistent left superior vena cava or a partial anomalous pulmonary venous connection. Other cardiovascular malformations are manifested directly after birth and need prompt mostly surgical interventions. At this point in time echocardiography is the diagnostic modality of choice for morphological and functional characterization of malformations. Additional imaging using computed tomography (CT) or magnetic resonance imaging (MRI) is only required in a minority of cases. If so, the small anatomical structures, the physiological tachycardia and tachypnea are a challenge for imaging modalities and strategies. This review article presents the most frequent vascular, cardiac and complex cardiovascular malformations independent of the first line diagnostic imaging modality. (orig.) [de

  14. CIRSE Vascular Closure Device Registry

    NARCIS (Netherlands)

    Reekers, Jim A.; Müller-Hülsbeck, Stefan; Libicher, Martin; Atar, Eli; Trentmann, Jens; Goffette, Pierre; Borggrefe, Jan; Zeleňák, Kamil; Hooijboer, Pieter; Belli, Anna-Maria

    2011-01-01

    Vascular closure devices are routinely used after many vascular interventional radiology procedures. However, there have been no major multicenter studies to assess the safety and effectiveness of the routine use of closure devices in interventional radiology. The CIRSE registry of closure devices

  15. Dynamic adaption of vascular morphology

    DEFF Research Database (Denmark)

    Okkels, Fridolin; Jacobsen, Jens Christian Brings

    2012-01-01

    The structure of vascular networks adapts continuously to meet changes in demand of the surrounding tissue. Most of the known vascular adaptation mechanisms are based on local reactions to local stimuli such as pressure and flow, which in turn reflects influence from the surrounding tissue. Here ...

  16. Diagnostic criteria for vascular dementia

    NARCIS (Netherlands)

    Scheltens, P.; Hijdra, A. H.

    1998-01-01

    The term vascular dementia implies the presence of a clinical syndrome (dementia) caused by, or at least assumed to be caused by, a specific disorder (cerebrovascular disease). In this review, the various sets of criteria used to define vascular dementia are outlined. The various sets of criteria

  17. The vascular secret of Klotho

    DEFF Research Database (Denmark)

    Lewin, Ewa; Olgaard, Klaus

    2015-01-01

    Klotho is an evolutionarily highly conserved protein related to longevity. Increasing evidence of a vascular protecting effect of the Klotho protein has emerged and might be important for future treatments of uremic vascular calcification. It is still disputed whether Klotho is locally expressed ...

  18. Social media in vascular surgery.

    Science.gov (United States)

    Indes, Jeffrey E; Gates, Lindsay; Mitchell, Erica L; Muhs, Bart E

    2013-04-01

    There has been a tremendous growth in the use of social media to expand the visibility of various specialties in medicine. The purpose of this paper is to describe the latest updates on some current applications of social media in the practice of vascular surgery as well as existing limitations of use. This investigation demonstrates that the use of social networking sites appears to have a positive impact on vascular practice, as is evident through the incorporation of this technology at the Cleveland Clinic and by the Society for Vascular Surgery into their approach to patient care and physician communication. Overall, integration of social networking technology has current and future potential to be used to promote goals, patient awareness, recruitment for clinical trials, and professionalism within the specialty of vascular surgery. Copyright © 2013 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.

  19. Síndrome torácico agudo en pacientes con anemia de células falciformes.

    Directory of Open Access Journals (Sweden)

    Paula ECKARDT

    1997-07-01

    Full Text Available We report an unusual lethal complication of sickle cell anemia. The patient was admitted with a diagnosis of acute chest syndrome and died shortly thereafter of respiratory failure. Autopsy revealed numerous deposits of bone marrow hematopoietic tissue occluding the microvascular circulation of the lung. Numerous causes of acute chest syndrome in sickle cell anemia have been identified, including pulmonary embolism from infartion of bone marrow. However, the release of bone marrow hematopoietic tissue leading to pulmonary vascular occlusion is not generally recognized pre-mortem by treating physicians. (Rev Med Hered 1997; 8:112-115.

  20. Vascular disease in cocaine addiction.

    Science.gov (United States)

    Bachi, Keren; Mani, Venkatesh; Jeyachandran, Devi; Fayad, Zahi A; Goldstein, Rita Z; Alia-Klein, Nelly

    2017-07-01

    Cocaine, a powerful vasoconstrictor, induces immune responses including cytokine elevations. Chronic cocaine use is associated with functional brain impairments potentially mediated by vascular pathology. Although the Crack-Cocaine epidemic has declined, its vascular consequences are increasingly becoming evident among individuals with cocaine use disorder of that period, now aging. Paradoxically, during the period when prevention efforts could make a difference, this population receives psychosocial treatment at best. We review major postmortem and in vitro studies documenting cocaine-induced vascular toxicity. PubMed and Academic Search Complete were used with relevant terms. Findings consist of the major mechanisms of cocaine-induced vasoconstriction, endothelial dysfunction, and accelerated atherosclerosis, emphasizing acute, chronic, and secondary effects of cocaine. The etiology underlying cocaine's acute and chronic vascular effects is multifactorial, spanning hypertension, impaired homeostasis and platelet function, thrombosis, thromboembolism, and alterations in blood flow. Early detection of vascular disease in cocaine addiction by multimodality imaging is discussed. Treatment may be similar to indications in patients with traditional risk-factors, with few exceptions such as enhanced supportive care and use of benzodiazepines and phentolamine for sedation, and avoiding β-blockers. Given the vascular toxicity cocaine induces, further compounded by smoking and alcohol comorbidity, and interacting with aging of the crack generation, there is a public health imperative to identify pre-symptomatic markers of vascular impairments in cocaine addiction and employ preventive treatment to reduce silent disease progression. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. [The future of vascular medicine].

    Science.gov (United States)

    Kroeger, K; Luther, B

    2014-10-01

    In the future vascular medicine will still have a great impact on health of people. It should be noted that the aging of the population does not lead to a dramatic increase in patient numbers, but will be associated with a changing spectrum of co-morbidities. In addition, vascular medical research has to include the intensive care special features of vascular patients, the involvement of vascular medicine in a holistic concept of fast-track surgery, a geriatric-oriented intensive monitoring and early geriatric rehabilitation. For the future acceptance of vascular medicine as a separate subject area under delimitation of cardiology and radiology is important. On the other hand, the subject is so complex and will become more complex in future specialisations that mixing of surgery and angiology is desirable, with the aim to preserve the vascular surgical knowledge and skills on par with the medical and interventional measures and further develop them. Only large, interdisciplinary guided vascular centres will be able to provide timely diagnosis and therapy, to deal with the growing multi-morbidity of the patient, to perform complex therapies even in an acute emergency and due to sufficient number of cases to present with well-trained and experienced teams. These requirements are mandatory to decrease patients' mortality step by step. Georg Thieme Verlag KG Stuttgart · New York.

  2. Contemporary vascular smartphone medical applications.

    Science.gov (United States)

    Carter, Thomas; O'Neill, Stephen; Johns, Neil; Brady, Richard R W

    2013-08-01

    Use of smartphones and medical mHealth applications (apps) within the clinical environment provides a potential means for delivering elements of vascular care. This article reviews the contemporary availability of apps specifically themed to major vascular diseases and the opportunities and concerns regarding their integration into practice. Smartphone apps relating to major vascular diseases were identified from the app stores for the 6 most popular smartphone platforms, including iPhone, Android, Blackberry, Nokia, Windows, and Samsung. Search terms included peripheral artery (arterial) disease, varicose veins, aortic aneurysm, carotid artery disease, amputation, ulcers, hyperhydrosis, thoracic outlet syndrome, vascular malformation, and lymphatic disorders. Forty-nine vascular-themed apps were identified. Sixteen (33%) were free of charge. Fifteen apps (31%) had customer satisfaction ratings, but only 3 (6%) had greater than 100. Only 13 apps (27%) had documented medical professional involvement in their design or content. The integration of apps into the delivery of care has the potential to benefit vascular health care workers and patients. However, high-quality apps designed by clinicians with vascular expertise are currently lacking and represent an area of concern in the mHealth market. Improvement in the quality and reliability of these apps will require the development of robust regulation. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Constructal vascularized structures

    Science.gov (United States)

    Cetkin, Erdal

    2015-06-01

    Smart features such as self-healing and selfcooling require bathing the entire volume with a coolant or/and healing agent. Bathing the entire volume is an example of point to area (or volume) flows. Point to area flows cover all the distributing and collecting kinds of flows, i.e. inhaling and exhaling, mining, river deltas, energy distribution, distribution of products on the landscape and so on. The flow resistances of a point to area flow can be decreased by changing the design with the guidance of the constructal law, which is the law of the design evolution in time. In this paper, how the flow resistances (heat, fluid and stress) can be decreased by using the constructal law is shown with examples. First, the validity of two assumptions is surveyed: using temperature independent Hess-Murray rule and using constant diameter ducts where the duct discharges fluid along its edge. Then, point to area types of flows are explained by illustrating the results of two examples: fluid networks and heating an area. Last, how the structures should be vascularized for cooling and mechanical strength is documented. This paper shows that flow resistances can be decreased by morphing the shape freely without any restrictions or generic algorithms.

  4. Evaluación económica del stent medicado vs. convencional para pacientes con infarto agudo de miocardio con elevación del ST en Colombia

    Directory of Open Access Journals (Sweden)

    Mateo Ceballos

    2014-11-01

    Conclusiones: El stent medicado con sirolimus no es costo-efectivo para pacientes con infarto agudo de miocardio con elevación del ST en Colombia. Se recomienda mayor investigación futura sobre la probabilidad de muerte y trombosis muy tardía del stent, así como en subgrupos específicos de pacientes y stents medicados de segunda generación.

  5. Diabetes and Retinal Vascular Dysfunction

    Directory of Open Access Journals (Sweden)

    Eui Seok Shin

    2014-01-01

    Full Text Available Diabetes predominantly affects the microvascular circulation of the retina resulting in a range of structural changes unique to this tissue. These changes ultimately lead to altered permeability, hyperproliferation of endothelial cells and edema, and abnormal vascularization of the retina with resulting loss of vision. Enhanced production of inflammatory mediators and oxidative stress are primary insults with significant contribution to the pathogenesis of diabetic retinopathy (DR. We have determined the identity of the retinal vascular cells affected by hyperglycemia, and have delineated the cell autonomous impact of high glucose on function of these cells. We discuss some of the high glucose specific changes in retinal vascular cells and their contribution to retinal vascular dysfunction. This knowledge provides novel insight into the molecular and cellular defects contributing to the development and progression of diabetic retinopathy, and will aid in the development of innovative, as well as target specific therapeutic approaches for prevention and treatment of DR.

  6. Vascular graft infections with Mycoplasma

    DEFF Research Database (Denmark)

    Levi-Mazloum, Niels Donald; Skov Jensen, J; Prag, J

    1995-01-01

    laboratory techniques, the percentage of culture-negative yet grossly infected vascular grafts seems to be increasing and is not adequately explained by the prior use of antibiotics. We have recently reported the first case of aortic graft infection with Mycoplasma. We therefore suggest the hypothesis...... that the large number of culture-negative yet grossly infected vascular grafts may be due to Mycoplasma infection not detected with conventional laboratory technique....

  7. Limb vascular function in women

    DEFF Research Database (Denmark)

    Hellsten, Ylva; Gliemann, Lasse

    2018-01-01

    Throughout life, women are subjected to both acute fluctuations in sex hormones, associated with the menstrual cycle, and chronic changes following the onset of menopause. Female sex hormones, and in particular estrogen, strongly influence cardiovascular function such as the regulation of vascular...... studies. Physical activity should be recommended for women of all ages, but the most essential timing for maintenance of vascular health may be from menopause and onwards....

  8. Facial vascular malformations in children

    International Nuclear Information System (INIS)

    Brunelle, F.O.; Lallemand, D.; Chaumont, P.; Teillac, D.; Manach, Y.

    1988-01-01

    The authors present their experience with conventional and digital angiography of vascular malformations of the head and neck in children. 22 hemangioendotheliomas, 8 venous angiomas, and 3 arteriovenous fistula were studied. 22 patients were embolised. DSA offers many advantages during the diagnostic as well as during the therapeutic phase of angiography. Embolization appears to have a major role in treatment of such vascular malformations. (orig.)

  9. Demoras en la realización de la angioplastia primaria en los pacientes trasladados con infarto agudo de miocardio: un problema médico-asistencial

    Directory of Open Access Journals (Sweden)

    Rodrigo Blanco

    2009-01-01

    Full Text Available IntroducciónEn el infarto agudo de miocardio (IAM está comprobado que cuanto más tempranamente se realice la reperfusión, mejores serán sus resultados a corto y a largo plazos, por lo que el tiempo entre el inicio de los síntomas y la reperfusión coronaria es un elemento de gran importancia en la estrategia de su tratamiento. Este lapso se encuentra conformado por dos períodos: “tiempo paciente” y “tiempo médico-asistencial”. En la angioplastia primaria, el análisis de estos tiempos y sus intervalos es el paso obligado para lograr una reducción de la demora a la reperfusión.ObjetivosAnalizar los tiempos en cada etapa del proceso traslado-realización de una angioplastia, ya sea primaria o de rescate, en pacientes con infarto agudo de miocardio con elevación del segmento ST (IAMEST que debieron ser trasladados desde un hospital derivador a un centro de referencia en el ámbito de la ciudad de Buenos Aires para someterse al procedimiento, como primer paso para un programa de optimización de los tiempos.Material y métodosEstudio prospectivo, observacional, de pacientes derivados al Hospital General de Agudos “Dr. Cosme Argerich” con diagnóstico de IAMEST e indicación de ATC. Se analizaron los tiempos parciales desde el inicio de los síntomas hasta la reperfusión coronaria, para lo cual se consideró “tiempo paciente” desde el inicio de los síntomas hasta la llegada al hospital derivador y “tiempo médico-asistencial” al comprendido entre la llegada al hospital derivador y la insuflación del balón.ResultadosSe incluyeron 313 pacientes, 225 (72% con angioplastia primaria (ATCP y 88 (28% con angioplastia de rescate (ATCR. Las medianas (cuartiles de tiempo en ATCP fueron: tiempo paciente: 90’ (40-240, llegada al hospital derivador-llamada al Equipo de Hemodinamia Cardiovascular de Urgencia (EHCU: 80’ (35-150, llamada EHCU-ingreso hemodinamia: 75’ (55-100, ingreso hemodinamia-balón: 35’ (23-52, tiempo m

  10. Angiogenesis, Cancer, and Vascular Aging

    Directory of Open Access Journals (Sweden)

    Junji Moriya

    2017-10-01

    Full Text Available Several lines of evidence have revealed that the angiogenic response to ischemic injury declines with age, which might account for the increased morbidity and mortality of cardiovascular disease (CVD among the elderly. While impairment of angiogenesis with aging leads to delayed wound healing or exacerbation of atherosclerotic ischemic diseases, it also inhibits the progression of cancer. Age-related changes of angiogenesis have been considered to at least partly result from vascular aging or endothelial cell senescence. There is considerable evidence supporting the hypothesis that vascular cell senescence contributes to the pathogenesis of age-related CVD, suggesting that vascular aging could be an important therapeutic target. Since therapeutic angiogenesis is now regarded as a promising concept for patients with ischemic CVD, it has become even more important to understand the detailed molecular mechanisms underlying impairment of angiogenesis in older patients. To improve the usefulness of therapeutic angiogenesis, approaches are needed that can compensate for impaired angiogenic capacity in the elderly while not promoting the development or progression of malignancy. In this review, we briefly outline the mechanisms of angiogenesis and vascular aging, followed by a description of how vascular aging leads to impairment of angiogenesis. We also examine potential therapeutic approaches that could enhance angiogenesis and/or vascular function in the elderly, as well as discussing the possibility of anti-senescence therapy or reversal of endothelial cell senescence.

  11. Implementación y resultados de un nuevo programa de ECMO para trasplante de pulmón y distrés respiratorio agudo

    Directory of Open Access Journals (Sweden)

    Eduardo San Roman

    2015-06-01

    Full Text Available RESUMEN Objetivo: El desarrollo de la membrana de oxigenación extracorpórea en América Latina representa un desafío para la especialidad. El objetivo de este artículo fue describir los resultados de un nuevo programa de membrana de oxigenación extracorpórea en una unidad de cuidados intensivos. Métodos: Estudio de cohorte retrospectivo. Incluye 22 pacientes que requirieron membrana de oxigenación extracorpórea desde Enero de 2011 hasta Junio de 2014. Se evaluaron características basales, indicaciones, duración de la corrida, días de ventilación mecánica, días de unidad de cuidados intensivos, complicaciones y mortalidad hospitalaria. Resultados: Quince pacientes requirieron membrana de oxigenación extracorpórea post-trasplante pulmonar y 7 pacientes por distrés respiratorio agudo. Todos los pacientes trasplantados fueron destetados de membrana de oxigenación extracorpórea, con una duración mediana de 3 días (Rango intercuantil - IQR: 2 - 5, de ventilación mecánica 15,5 días (IQR: 3 - 35, de estadía unidad de cuidados intensivos 31,5 días (IQR: 19 - 53 y de estadía hospitalaria 60 días (IQR: 36 - 89, con una mortalidad de 20%. Los pacientes con distrés respiratorio agudo tuvieron una mediana de duración de membrana de oxigenación extracorpórea de 9 días (IQR: 3 - 14, mediana de ventilación mecánica 25 días (IQR: 13 - 37, de estadía en terapia 31 días (IQR: 11 - 38, y hospitalaria 32 días (IQR: 11 - 41, y 57% de mortalidad. Las principales complicaciones fueron infecciones (80%, insuficiencia renal aguda (43%, sangrados en sitio quirúrgico y de inserción de cánulas (22%, plaquetopenia (60% y coagulopatía (30%. Conclusión: A pesar de encontrarnos transitando una curva de aprendizaje, consideramos la experiencia satisfactoria, con resultados y complicaciones comparables a las reportadas en la literatura.

  12. Hiperglucemia en el síndrome coronario agudo: informe científico multidisciplinario Hyperglycemia in acute coronary syndrome: multidisciplinary scientific report

    Directory of Open Access Journals (Sweden)

    Patricia Blanco

    2012-04-01

    Full Text Available La hiperglucemia con o sin diabetes preexistente es un hallazgo frecuente en pacientes que cursan un síndrome coronario agudo. Estudios previos han demostrado que la hiperglucemia es altamente prevalente y se asocia a un mayor riesgo de muerte y complicaciones hospitalarias. Los mecanismos fisiopatológicos mediante los cuales la hiperglucemia provoca resultados adversos no son claros, y se desconoce si es un marcador de eventos o su causa. Los efectos perjudiciales de la hiperglucemia en el sistema cardiovascular son múltiples, y el control de los niveles de glucosa con insulina parece mejorar el pronóstico en estos pacientes. Se han desarrollado numerosos protocolos para el control de glucemia que demostraron ser seguros y efectivos. En una iniciativa originada en el Consejo de Emergencias de la Sociedad Argentina de Cardiología, se convocó a expertos de nuestro medio con el propósito de debatir estrategias para el control de la glucemia en pacientes que cursan un síndrome coronario agudo. Este documento refleja lo discutido en este evento académico con la intención de resumir los principales aspectos del control de la glucemia y ofrecer recomendaciones generales de tratamiento en la Unidad Coronaria.Hyperglycemia with or without pre-existing diabetes mellitus, occurs frequently in the setting of acute coronary syndrome. Previous studies have demonstrated that hyperglycemia is highly prevalent and is associated with an increased risk of hospital complications and death. The underlying pathophysiology related an adverse clinical outcome to hyperglycemia is unclear, and it is uncertain whether increased serum glucose is simply a marker of adverse outcomes or their cause. Detrimental effects of hyperglycemia on the cardiovascular system are multiple. Glycemia control with insulin would prevent adverse outcomes. Numerous glucose-control protocols have been developed and tested proving to be safe and effective. In an initiative from the

  13. Efecto diurético agudo de los extractos etanólico y acuoso de Ceratopteris pteridoides (Hook en ratas normales

    Directory of Open Access Journals (Sweden)

    Antistio Aníbal Alviz

    2013-03-01

    Full Text Available Introducción. Ceratopteris pteridoides es un helecho semiacuático de la familia Parkeriacea, ampliamente utilizado en la medicina popular colombiana como diurético y colelitiásico, sobre el cual no existen reportes científicos que avalen su uso popular como diurético. Objetivo. Evaluar el efecto diurético agudo en dosis única y dosis repetidas a corto plazo, de los extractos etanólico y acuoso de C. pteridoides en un modelo in vivo. Materiales y métodos. El extracto etanólico total fue obtenido por maceración de la planta entera de C. pteridoides con etanol y el extracto acuoso fue obtenido por decocción a 60 °C por 15 minutos. Ambos extractos se sometieron a análisis fitoquímico preliminar y estudio histológico posterior a la administración de los extractos durante ocho días consecutivos (1.000 mg/kg. El efecto diurético se evaluó en ratas Wistar, tratadas con los extractos (500 mg/kg, en forma aguda y en dosis repetidas a corto plazo, cuantificando la eliminación de agua y la excreción renal de sodio y potasio por espectrofotometría de absorción atómica y, de cloruros, por titulación mercurimétrica. Resultados. En el modelo agudo, ambos extractos mostraron un significativo efecto diurético y de excreción renal de sodio y potasio en comparación con el control, mientras que con la administración en dosis repetidas a corto plazo mostraron efecto diurético sin eliminación de electrolitos. El estudio histopatológico no sugirió efectos tóxicos hepáticos o renales. Conclusión. Los resultados demuestran la actividad diurética de C. pteridoides y sustentan el uso popular dado a esta planta como diurético en la costa norte colombiana. Se requieren estudios posteriores que permitan aislar e identificar los compuestos responsables de la actividad y los mecanismos de acción involucrados.   doi: http://dx.doi.org/10.7705/biomedica.v33i1.611

  14. Calcium dynamics in vascular smooth muscle

    OpenAIRE

    Amberg, Gregory C.; Navedo, Manuel F.

    2013-01-01

    Smooth muscle cells are ultimately responsible for determining vascular luminal diameter and blood flow. Dynamic changes in intracellular calcium are a critical mechanism regulating vascular smooth muscle contractility. Processes influencing intracellular calcium are therefore important regulators of vascular function with physiological and pathophysiological consequences. In this review we discuss the major dynamic calcium signals identified and characterized in vascular smooth muscle cells....

  15. Injuries to the vascular endothelium: vascular wall and endothelial dysfunction.

    Science.gov (United States)

    Fisher, Mark

    2008-01-01

    Vascular endothelial injury has multiple elements, and this article focuses on ischemia-related processes that have particular relevance to ischemic stroke. Distinctions between necrotic and apoptotic cell death provide a basic science context in which to better understand the significance of classical core and penumbra concepts of acute stroke, with apoptotic processes particularly prominent in the penumbra. The mitochondria are understood to serve as a reservoir of proteins that mediate apoptosis. Oxidative stress pathways generating reactive oxygen species (ROS) are prominent in endothelial injury, both ischemic and nonischemic, with prominent roles of enzyme- and nonenzymemediated pathways; mitochondria once again have a critical role, particularly in the nonenzymatic pathways generating ROS. Inflammation also contributes to vascular endothelial injury, and endothelial cells have the capacity to rapidly increase expression of inflammatory mediators following ischemic challenge; this leads to enhanced leukocyte-endothelial interactions mediated by selectins and adhesion molecules. Preconditioning consists of a minor version of an injurious event, which in turn may protect vascular endothelium from injury following a more substantial event. Presence of the blood-brain barrier creates unique responses to endothelial injury, with permeability changes due to impairment of endothelial-matrix interactions compounding altered vasomotor tone and tissue perfusion mediated by nitric oxide. Pharmacological protection against vascular endothelial injury can be provided by several of the phosphodiesterases (cilostazol and dipyridamole), along with statins. Optimal clinical responses for protection of brain vascular endothelium may use preconditioning as a model, and will likely require combined protection against apoptosis, ROS, and inflammation.

  16. Non-invasive vascular imaging: assessing tumour vascularity

    International Nuclear Information System (INIS)

    Delorme, S.; Knopp, M.V.

    1998-01-01

    Non-invasive assessment of vascularity is a new diagnostic approach to characterise tumours. Vascular assessment is based on the pathophysiology of tumour angiogenesis and its diagnostic implications for tumour biology, prognosis and therapy response. Two current techniques investigating vascular features in addition to morphology are Doppler ultrasonography and contrast-enhanced MRI. Diagnostic differentiation has been shown to be possible with Doppler, and a high degree of observed vascularity could be linked to an aggressive course of the disease. Dynamic MRI using gadolinium chelates is already used clinically to detect and differentiate tumours. The histological correlation shows that capillary permeability is increased in malignant tumours and is the best criterion for differentiation from benign processes. Permeability and perfusion factors seem to be more diagnostic than overall vessel density. New clinical applications are currently being established for therapy monitoring. Further instrumental developments will bring harmonic imaging in Doppler, and faster imaging techniques, higher spatial resolution and novel pharmacokinetic concepts in MRI. Upcoming contrast agents for both Doppler and MRI will further improve estimation of intratumoural blood volume and vascular permeability. (orig.)

  17. Edema agudo pulmonar associado à obstrução das vias aéreas: relato de caso Edema agudo pulmonar asociado a la obstrucción de las vías aéreas: relato de caso Acute pulmonary edema associated with obstruction of the airways: case report

    Directory of Open Access Journals (Sweden)

    Flora Margarida Barra Bisinotto

    2008-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O edema pulmonar por pressão negativa tem sido definido como edema não-cardiogênico, com transudação de líquido para o interstício pulmonar, por aumento na pressão negativa intratorácica, ocasionado pela obstrução das vias aéreas superiores. Descreveu-se o caso de paciente hígida, submetida à anestesia geral, que apresentou edema agudo pulmonar após a extubação traqueal. RELATO DO CASO: Paciente de 23 anos, sexo feminino, estado físico ASA II, submetida à anestesia geral para videolaparoscopia ginecológica. O procedimento durou 3 horas, sem intercorrências. Após a extubação, a paciente apresentou laringoespasmo e diminuição da saturação de oxigênio. Houve melhora após colocação de cânula oral e administração de oxigênio, sob pressão positiva, com máscara facial. Estabilizado o quadro, foi encaminhada à sala de recuperação pós-anestésica, onde, logo após a admissão, apresentou edema agudo de pulmão com eliminação de secreção serossanguinolenta. O tratamento constou de elevação do dorso, oxigênio sob máscara, furosemida e restrição hídrica. A radiografia torácica mostrou imagem compatível com edema agudo pulmonar e área cardíaca normal. O eletrocardiograma (ECG, ecocardiografia e enzimas cardíacas estavam normais. A paciente apresentou boa evolução, recebendo alta hospitalar no dia seguinte, assintomática. CONCLUSÕES: O edema agudo de pulmão associado à obstrução das vias aéreas superiores é condição clínica que pode agravar procedimentos cirúrgicos de baixa morbidade e que aparece sobretudo em pacientes jovens. O tratamento deve ser instituído precocemente, pois a resolução também é rápida e, na maioria das vezes, sem seqüelas.JUSTIFICATIVA Y OBJETIVOS: El edema pulmonar por presión negativa ha sido definido como edema no cardiogénico, con transudación de líquido para el intersticio pulmonar, por aumento en la presión negativa

  18. Pediatric interventional radiology: vascular interventions

    International Nuclear Information System (INIS)

    Kandasamy, Devasenathipathy; Gamanagatti, Shivanand; Gupta, Arun Kumar

    2016-01-01

    Pediatric interventional radiology (PIR) comprises a range of minimally invasive diagnostic and therapeutic procedures that are performed using image guidance. PIR has emerged as an essential adjunct to various surgical and medical conditions. Over the years, technology has undergone dramatic and continuous evolution, making this speciality grow. In this review, the authors will discuss various vascular interventional procedures undertaken in pediatric patients. It is challenging for the interventional radiologist to accomplish a successful interventional procedure. There are many vascular interventional radiology procedures which are being performed and have changed the way the diseases are managed. Some of the procedures are life saving and have become the treatment of choice in those patients. The future is indeed bright for the practice and practitioners of pediatric vascular and non-vascular interventions. As more and more of the procedures that are currently being performed in adults get gradually adapted for use in the pediatric population, it may be possible to perform safe and successful interventions in many of the pediatric vascular lesions that are otherwise being referred for surgery. (author)

  19. Detecção de Treponema denticola em casos de abscesso perirradicular agudo Detection of Treponema denticola in cases of acute periradicular abscesses

    Directory of Open Access Journals (Sweden)

    Isabela das Neves RÔÇAS

    2000-09-01

    Full Text Available Nosso objetivo foi detectar Treponema denticola em casos de abscesso perirradicular agudo. O DNA extraído das amostras de pus foi examinado pelo método da "Polymerase Chain Reaction" direcionada para o gene do RNAr (fração 16S. A amplificação usando o "primer" da espécie Treponema denticola permitiu detectá-la em 5 dos 6 casos de abscessos examinados. Apenas uma banda de tamanho esperado foi observada para as amostras positivas para esta bactéria, o que foi confirmado pela comparação com o DNA de referência do Treponema denticola (controle positivo. Até o momento, este é o primeiro relato da presença desta espiroqueta, considerada um importante patógeno periodontal em infecções endodônticas. Os resultados sugerem que Treponema denticola também pode ser um importante patógeno endodôntico.The purpose of this study was to report the detection of Treponema denticola in five out of six cases of acute periradicular abscesses. The 16S rRNA gene directed Polymerase Chain Reaction was the method utilized. This is probably the first report hitherto of the occurrence of this spirochete in acute periradicular abscesses.

  20. Precisión diagnóstica de un modelo de redes bayesianas en los síndromes coronarios agudos

    Directory of Open Access Journals (Sweden)

    John Sprockel

    2015-08-01

    Full Text Available Introducción: La caracterización diagnóstica del dolor torácico, con énfasis en los síndromes coronarios agudos (SCA es un requerimiento primordial para los médicos del área de urgencias. Objetivos: En el presente estudio se busca diseñar y evaluar el desempeño de las redes bayesianas en el apoyo al diagnóstico de los SCA. Metodología: Se trata de un estudio de pruebas diagnósticas en el cual se diseñaron dos modelos de redes bayesianas entrenadas en el framework OpenMarkov, a partir de las variables de la escala de probabilidad de Braunwald de angina en un grupo de 159 pacientes que luego se validó en una cohorte de 108 pacientes adultos hospitalizados con sospecha de un SCA en un hospital de tercer nivel de atención. Resultados: Se obtuvo una sensibilidad baja aunque con especificidad y valor predictivo positivo adecuados (62, 86 y 87% respectivamente. El rendimiento fue mejor en los casos que tuvieron electrocardiograma y biomarcadores negativos. Conclusiones: Un modelo de redes Bayesianas entrenado a partir de las variables de la escala de probabilidad de angina inestable de Braunwald, presenta un rendimiento aceptable para el diagnóstico de los SCA.

  1. Tomografia computadorizada sem contraste intravenoso no abdome agudo: quando e por que usar When and why use unenhanced computed tomography in patients with acute abdomen

    Directory of Open Access Journals (Sweden)

    Edison de Oliveira Freire Filho

    2006-02-01

    Full Text Available A tomografia computadorizada sem contraste intravenoso tem sido freqüentemente proposta na avaliação inicial de pacientes com suspeita de abdome agudo, ocupando o espaço de outros métodos diagnósticos. Os autores apresentam uma revisão bibliográfica dos principais aspectos e eficácia da tomografia computadorizada sem contraste intravenoso no diagnóstico de apendicite aguda, cólica nefrética, diverticulite, pancreatite aguda, apendicite epiplóica, pneumoperitônio e obstrução intestinal. Discutem quais as vantagens e limitações desta técnica de exame, bem como seus aspectos práticos.The use of unenhanced computed tomography has been frequently recommended for the initial assessment of patients with clinical suspicion of acute abdomen instead of other diagnostic methods. The authors present a review of the literature on the main aspects, advantages, limitations and efficacy of unenhanced computed tomography for the diagnosis of acute appendicitis, renal colic, diverticulitis, acute pancreatitis, primary epiploic appendicitis, pneumoperitoneum and small bowel obstruction. The advantages and limitations of this technique are also discussed.

  2. Acute gastric volvulus: report of a case Vólvulo gástrico agudo: etiopatogénesis, diagnóstico y tratamiento

    Directory of Open Access Journals (Sweden)

    Sergio Hoyos

    1997-03-01

    Full Text Available This paper presents a case of acute gastric volvulus related to diaphragmatic elevation due to a lung resection performed twenty eight years before, as a consequence of pulmonary tuberculosis. Gastric volvulus is rarely found; the disorder is usually chronic and originales from concurrent diaphragmatic defects or derangements. Pathogenesis and diagnosis of acute gastric volvulus as well as different treatment alternatives are discussed. Se presenta un caso de vólvulo gástrico agudo asociado a elevación del diafragma, secundaria a una neumonectomía practicada 28 años antes por tuberculosis pulmonar. El vólvulo gástrico es una entidad clínica poco frecuente que ocurre, en general, en forma crónica y secundaria a patología diafragmática. Se discuten la etiopatogénesis, el diagnóstico y las diferentes alternativas de tratamiento en pacientes con esta entidad.

  3. ANÁLISIS COMPARATIVO DE LOS EFECTOS AGUDOS DE SESIONES DE ENTRENAMIENTO DE FUERZA CON CARGAS DEL 90 Y 30% 1 RM.

    Directory of Open Access Journals (Sweden)

    Jorge Dopico Calvo

    2010-10-01

    Full Text Available En una medición inicial (Pretest se obtuvo la 1RM de 23 sujetos masculinos en el ejercicio press banca, así como la potencia y fuerza media aplicada al 90 y 30% de 1RM (PMED90, FMED90, PMED30, FMED 30. Posteriormente 11 sujetos (Gr90 llevaron a cabo 2 sesiones de entrenamiento con cargas del 90%, mientras los 12 sujetos restantes (Gr30 lo hacían con cargas del 30%. Inmediatamente finalizada cada una de las sesiones se valoraba nuevamente PMED90, FMED90, PMED30, FMED30. Una semana después de la finalización de los entrenamientos se efectuó un Postest. Los resultados mostraron una mejora estadísticamente significativa del rendimiento de Gr30 al final de cada una de las sesiones de entrenamiento, respecto a Pretest y Postest, con el 90% de 1RM, mientras que Gr90 obtuvo mejoras significativas con el 30% respecto a Pretest, pero no respecto a Postest.
    PALABRAS CLAVE: fuerza, potencia, medición, efecto agudo.

  4. Fetal origin of vascular aging

    Directory of Open Access Journals (Sweden)

    Shailesh Pitale

    2011-01-01

    Full Text Available Aging is increasingly regarded as an independent risk factor for development of cardiovascular diseases such as atherosclerosis and hypertension and their complications (e.g. MI and Stroke. It is well known that vascular disease evolve over decades with progressive accumulation of cellular and extracellular materials and many inflammatory processes. Metabolic syndrome, obesity and diabetes are conventionally recognized as risk factors for development of coronary vascular disease (CVD. These conditions are known to accelerate ageing process in general and vascular ageing in particular. Adverse events during intrauterine life may programme organ growth and favour disease later in life, popularly known as, ′Barker′s Hypothesis′. The notion of fetal programming implies that during critical periods of prenatal growth, changes in the hormonal and nutritional milieu of the conceptus may alter the full expression of the fetal genome, leading to permanent effects on a range of physiological.

  5. Imaging after vascular gene therapy

    International Nuclear Information System (INIS)

    Manninen, Hannu I.; Yang, Xiaoming

    2005-01-01

    Targets for cardiovascular gene therapy currently include limiting restenosis after balloon angioplasty and stent placement, inhibiting vein bypass graft intimal hyperplasia/stenosis, therapeutic angiogenesis for cardiac and lower-limb ischemia, and prevention of thrombus formation. While catheter angiography is still standard method to follow-up vascular gene transfer, other modern imaging techniques, especially intravascular ultrasound (IVUS), magnetic resonance (MR), and positron emission tomography (PET) imaging provide complementary information about the therapeutic effect of vascular gene transfer in humans. Although molecular imaging of therapeutic gene expression in the vasculatures is still in its technical development phase, it has already offered basic medical science an extremely useful in vivo evaluation tool for non- or minimally invasive imaging of vascular gene therapy

  6. Vascular Gene Expression: A Hypothesis

    Directory of Open Access Journals (Sweden)

    Angélica Concepción eMartínez-Navarro

    2013-07-01

    Full Text Available The phloem is the conduit through which photoassimilates are distributed from autotrophic to heterotrophic tissues and is involved in the distribution of signaling molecules that coordinate plant growth and responses to the environment. Phloem function depends on the coordinate expression of a large array of genes. We have previously identified conserved motifs in upstream regions of the Arabidopsis genes, encoding the homologs of pumpkin phloem sap mRNAs, displaying expression in vascular tissues. This tissue-specific expression in Arabidopsis is predicted by the overrepresentation of GA/CT-rich motifs in gene promoters. In this work we have searched for common motifs in upstream regions of the homologous genes from plants considered to possess a primitive vascular tissue (a lycophyte, as well as from others that lack a true vascular tissue (a bryophyte, and finally from chlorophytes. Both lycophyte and bryophyte display motifs similar to those found in Arabidopsis with a significantly low E-value, while the chlorophytes showed either a different conserved motif or no conserved motif at all. These results suggest that these same genes are expressed coordinately in non- vascular plants; this coordinate expression may have been one of the prerequisites for the development of conducting tissues in plants. We have also analyzed the phylogeny of conserved proteins that may be involved in phloem function and development. The presence of CmPP16, APL, FT and YDA in chlorophytes suggests the recruitment of ancient regulatory networks for the development of the vascular tissue during evolution while OPS is a novel protein specific to vascular plants.

  7. [Vascular Calcification - Pathological Mechanism and Clinical Application - . Role of vascular smooth muscle cells in vascular calcification].

    Science.gov (United States)

    Kurabayashi, Masahiko

    2015-05-01

    Vascular calcification is commonly seen with aging, chronic kidney disese (CKD), diabetes, and atherosclerosis, and is closely associated with cardiovascular morbidity and mortality. Vascular calcification has long been regarded as the final stage of degeneration and necrosis of arterial wall and a passive, unregulated process. However, it is now known to be an active and tightly regulated process involved with phenotypic transition of vascular smooth muscle cells (VSMC) that resembles bone mineralization. Briefly, calcium deposits of atherosclerotic plaque consist of hydroxyapatite and may appear identical to fully formed lamellar bone. By using a genetic fate mapping strategy, VSMC of the vascular media give rise to the majority of the osteochondrogenic precursor- and chondrocyte-like cells observed in the calcified arterial media of MGP (- / -) mice. Osteogenic differentiation of VSMC is characterized by the expression of bone-related molecules including bone morphogenetic protein (BMP) -2, Msx2 and osteopontin, which are produced by osteoblasts and chondrocytes. Our recent findings are that (i) Runx2 and Notch1 induce osteogenic differentiation, and (ii) advanced glycation end-product (AGE) /receptor for AGE (RAGE) and palmitic acid promote osteogenic differentiation of VSMC. To understand of the molecular mechanisms of vascular calcification is now under intensive research area.

  8. Vascular malforma- tions part 1 — normal and abnormal vascular ...

    African Journals Online (AJOL)

    Enrique

    to form the primitive vascular plexus. Angiogenesis is the formation of new vessels by sprouting or splitting of ... The differentiation of primitive vessels into arteries, veins or capillaries is determined by flow patterns .... identify, but it is probable that as time progresses further specific genetic defects related to the development ...

  9. Genetic Regulation of Vascular Development: Building the Zebrafish Vascular Tree

    NARCIS (Netherlands)

    R.L.J.M. Herpers (Robert)

    2010-01-01

    textabstractThe extensive networks of blood and lymphatic vessels within the vertebrate body are essential for the transport and delivery of fluids, gases, macromolecules and cells, and play important roles in facilitating immune responses. The development of the vascular tree requires a highly

  10. [Vascular access guidelines for hemodialysis].

    Science.gov (United States)

    Rodríguez Hernández, J A; González Parra, E; Julián Gutiérrez, J M; Segarra Medrano, A; Almirante, B; Martínez, M T; Arrieta, J; Fernández Rivera, C; Galera, A; Gallego Beuter, J; Górriz, J L; Herrero, J A; López Menchero, R; Ochando, A; Pérez Bañasco, V; Polo, J R; Pueyo, J; Ruiz, Camps I; Segura Iglesias, R

    2005-01-01

    Quality of vascular access (VA) has a remarkable influence in hemodialysis patients outcomes. Dysfunction of VA represents a capital cause of morbi-mortality of these patients as well an increase in economical. Spanish Society of Neprhology, aware of the problem, has decided to carry out a revision of the issue with the aim of providing help in comprehensión and treatment related with VA problems, and achieving an homogenization of practices in three mayor aspects: to increase arteriovenous fistula utilization as first vascular access, to increment vascular access monitoring practice and rationalise central catheters use. We present a consensus document elaborated by a multidisciplinar group composed by nephrologists, vascular surgeons, interventional radiologysts, infectious diseases specialists and nephrological nurses. Along six chapters that cover patient education, creation of VA, care, monitoring, complications and central catheters, we present the state of the art and propose guidelines for the best practice, according different evidence based degrees, with the intention to provide help at the professionals in order to make aproppiate decissions. Several quality standars are also included.

  11. Image Quality in Vascular Radiology

    International Nuclear Information System (INIS)

    Vanhavere, F.; Struelens, L.

    2005-01-01

    In vascular radiology, the radiologists use the radiological image to diagnose or treat a specific vascular structure. From literature, we know that related doses are high and that large dose variability exists between different hospitals. The application of the optimization principle is therefore necessary and is obliged by the new legislation. So far, very little fieldwork has been performed and no practical instructions are available to do the necessary work. It's indisputable that obtaining quantitative data is of great interest for optimization purposes. In order to gain insight into these doses and the possible measures for dose reduction, we performed a comparative study in 7 hospitals. Patient doses will be measured and calculated for specific procedures in vascular radiology and evaluated against their most influencing parameters. In view of optimization purposes, a protocol for dose audit will be set-up. From the results and conclusions in this study, experimentally based guidelines will be proposed, in order to improve clinical practice in vascular radiology

  12. Vascular aspects of multiple sclerosis

    NARCIS (Netherlands)

    D'haeseleer, Miguel; Cambron, Melissa; Vanopdenbosch, Ludo; De Keyser, Jacques

    Three types of vascular dysfunction have been described in multiple sclerosis (MS). First, findings from epidemiological studies suggest that patients with MS have a higher risk for ischaemic stroke than people who do not have MS. The underlying mechanism is unknown, but might involve endothelial

  13. Subclinical hypothyroidism after vascular complicated pregnancy

    NARCIS (Netherlands)

    Zanden, M. van der; Hop-de Groot, R.J.; Sweep, F.C.; Ross, H.A.; Heijer, M. den; Spaanderman, M.E.A.

    2013-01-01

    OBJECTIVE: Women with a history of vascular complicated pregnancy are at risk for developing remote cardiovascular disease. It is associated with underlying cardiovascular risk factors both jeopardizing trophoblast and vascular function. Subclinical hypothyroidism may relate to both conditions.

  14. Pediatric central nervous system vascular malformations

    International Nuclear Information System (INIS)

    Burch, Ezra A.; Orbach, Darren B.

    2015-01-01

    Pediatric central nervous system (CNS) vascular anomalies include lesions found only in the pediatric population and also the full gamut of vascular lesions found in adults. Pediatric-specific lesions discussed here include infantile hemangioma, vein of Galen malformation and dural sinus malformation. Some CNS vascular lesions that occur in adults, such as arteriovenous malformation, have somewhat distinct manifestations in children, and those are also discussed. Additionally, children with CNS vascular malformations often have associated broader vascular conditions, e.g., PHACES (posterior fossa anomalies, hemangioma, arterial anomalies, cardiac anomalies, eye anomalies and sternal anomalies), hereditary hemorrhagic telangiectasia, and capillary malformation-arteriovenous malformation syndrome (related to the RASA1 mutation). The treatment of pediatric CNS vascular malformations has greatly benefited from advances in endovascular therapy, including technical advances in adult interventional neuroradiology. Dramatic advances in therapy are expected to stem from increased understanding of the genetics and vascular biology that underlie pediatric CNS vascular malformations. (orig.)

  15. Pediatric central nervous system vascular malformations

    Energy Technology Data Exchange (ETDEWEB)

    Burch, Ezra A. [Brigham and Women' s Hospital, Department of Radiology, Boston, MA (United States); Orbach, Darren B. [Boston Children' s Hospital, Neurointerventional Radiology, Boston, MA (United States)

    2015-09-15

    Pediatric central nervous system (CNS) vascular anomalies include lesions found only in the pediatric population and also the full gamut of vascular lesions found in adults. Pediatric-specific lesions discussed here include infantile hemangioma, vein of Galen malformation and dural sinus malformation. Some CNS vascular lesions that occur in adults, such as arteriovenous malformation, have somewhat distinct manifestations in children, and those are also discussed. Additionally, children with CNS vascular malformations often have associated broader vascular conditions, e.g., PHACES (posterior fossa anomalies, hemangioma, arterial anomalies, cardiac anomalies, eye anomalies and sternal anomalies), hereditary hemorrhagic telangiectasia, and capillary malformation-arteriovenous malformation syndrome (related to the RASA1 mutation). The treatment of pediatric CNS vascular malformations has greatly benefited from advances in endovascular therapy, including technical advances in adult interventional neuroradiology. Dramatic advances in therapy are expected to stem from increased understanding of the genetics and vascular biology that underlie pediatric CNS vascular malformations. (orig.)

  16. ESRD QIP - Vascular Access - Payment Year 2018

    Data.gov (United States)

    U.S. Department of Health & Human Services — This dataset includes facility details, performance rates, vascular access topic measure score, and the state and national average measure scores for the vascular...

  17. Acute clinical events in patients with sickle cell disease: epidemiology and treatment Eventos agudos em doença falciforme: epidemiologia e tratamento

    Directory of Open Access Journals (Sweden)

    Monique M. Loureiro

    2008-04-01

    Full Text Available Sickle cell disease is a hereditary illness of high prevalence in black population, and involved patients frequently have multiple hospitalizations. Our objective was to describe and to analyze the clinical course of hospitalizations in patients with sickle cell disease. Cross-sectional study of 78 patients submitted to 230 hospital admissions due to acute complications of sickle cell disease, from 2000 to 2004 in a public teaching hospital in Rio de Janeiro city, RJ, Brazil. Outcomes variables were length of hospital stay and death. Main covariables were age, gender, chronic renal failure, causes of hospitalization and use of medicines. Proportions were compared using the chi-square or the Fischer test, and for the continuous variables, Mann-Whitney test was used. The median age in years was 20.3 (15-53 and the most frequent clinical event was acute painful episode (73.5%. Mean length of stay was significantly higher in admissions caused by different reasons than acute painful episode (p A doença falciforme é uma doença hereditária, de alta prevalência na população negra, que leva a múltiplas internações hospitalares. Nosso objetivo foi descrever e analisar o curso clínico de pacientes com doença falciforme hospitalizados.Realizou-se estudo transversal de 78 pacientes submetidos a 230 internações hospitalares devido a complicações agudas da doença falciforme, de 2000 a 2004, em um hospital universitário no Rio de Janeiro-RJ, Brasil. Os desfechos estudados foram tempo de permanência hospitalar e óbito. As principais co-variáveis foram idade, sexo, presença de insuficiência renal crônica, causas de hospitalização e uso de medicamentos. Proporções foram comparadas utilizando-se o teste qui-quadrado ou teste de Fischer, e, para as variáveis contínuas, o teste de Mann-Whitney foi utilizado. A mediana da idade foi 20,3 anos (15-23 e o evento clínico mais freqüente foi o episódio doloroso agudo (73,5%. O tempo m

  18. Síndrome de Distrés Respiratorio Agudo: Utilidad de los Corticoides Acute respiratory distress syndrome: Role of steroids

    Directory of Open Access Journals (Sweden)

    Célica L. Irrazábal

    2004-06-01

    Full Text Available En Argentina, el síndrome de distrés respiratorio agudo (SDRA representa el 7.7% de las admisiones en terapia intensiva y está asociado con una alta morbilidad y mortalidad (58%. Con frecuencia la muerte puede ser atribuida a más de una causa. La hipoxemia refractaria es una causa de muerte poco frecuente (15% y en muchos casos puede coexistir con disfunción multiorgánica, sepsis o shock séptico. La utilidad de los esteroides como parte del tratamiento es aún motivo de debate a pesar de las múltiples series de casos y estudios clínicos publicados. En el artículo se evalúa la utilidad de los esteroides en el SDRA a través de la revisión de la bibliografía disponible. Se concluye que los esteroides estarían indicados en un pequeño subgrupo de pacientes con SDRA no resuelto o tardío, después de descartar o controlar una infección activa.The acute respiratory distress syndrome (ARDS represents 7.7% of the intensive care population, and is associated with great morbidity and mortality (58%. Frequently, the mortality can be attributed to more than one cause. Refractory hypoxemia is uncommon (15% and most of the patients also have multiple organic dysfunction, sepsis or septic shock. Although there are many publications concerning series of cases and clinical trials using steroids as a part of the treatment of ARDS, this issue remains controversial. In this article the role of steroids in the ARDS is evaluated by analysis of the available literature. We conclude that steroids are useful in a subgroup of patients with unresolving ARDS, after ruling out an active infection or after treatment with antibiotics.

  19. Efeitos cardiovasculares agudos do exercício resistido em idosas hipertensas = Cute cardiovascular effects of resistence exercise on hypertensive elderly women

    Directory of Open Access Journals (Sweden)

    Kleverton Krinski

    2008-07-01

    Full Text Available O objetivo deste estudo foi avaliar os efeitos cardiovasculares agudos do exercício resistido (ER em idosas com hipertensão estágio I. Participaram 24 hipertensas (63,7 ± 3,7 anos, submetidas a uma sessão de ER, constituída por oito estações (três séries,12 repetições, 50% 1 RM. A frequência cardíaca (FC, a pressão arterial sistólica (PAS e a diastólica (PAD foram mensuradas anteriormente ao início dos exercícios (A, imediatamente após a quinta estação (B e 10 min. após a sessão de exercícios (C. Anova demedidas repetidas e post-hoc Tukey (p The aim of this study was to evaluate the effect of acute cardiovascular responses of resistance exercise (RE on stage I hypertensive elderly women. Twenty four hypertensive women (63.7 ± 3.7 years were subjected a session of RE, with eight stations(3 sets, 12 repetitions, 50% 1 RM. The heart rate (HR, systolic blood pressure (SBP and blood pressure (DBP were measured before the exercise sessions (A, immediately after the fifth station (B, and 10 minutes after the exercise sessions (C. Repeated measuresAnova and post-hoc Tukey test (p < 0.05 were performed. The results demonstrated significant increase in SBP, DBP and HR (p < 0.05 between the A and B conditions. Subsequently, SBP and DBP decreased significantly for the C condition as compared to the B condition (p < 0.05; however, only DBP decreased significantly for the A condition (p < 0.05. Although the results demonstrated that acute cardiovascular modifications are associated with RE, hypotensive effects were only verified on DBP.

  20. Comportamiento del Intervalo QT corregido prolongado en el síndrome coronario agudo, sin elevación del segmento ST

    Directory of Open Access Journals (Sweden)

    Amauris Modesto Valera Sales

    2015-12-01

    Full Text Available Se realizó un estudio descriptivo transversal prospectivo, para determinar el comportamiento del intervalo QT corregido prolongado, en pacientes con síndrome coronario agudo sin elevación del segmento ST, en el Centro Diagnóstico Integral “Los Arales”, San Diego, año 2009. El universo fue de 48 pacientes y la muestra incluyó a 29 pacientes con ECG normal o sin nuevos cambios isquémicos. Al ingreso se determinaron los valores del intervalo QT corregido, las variables demográficas, antecedentes personales, niveles enzimáticos de CK-MB y el score TIMI. Estos resultados se correlacionaron con la aparición de eventos clínicos (muerte, infarto no fatal y revascularización un mes después del ingreso. De los 29 pacientes analizados sólo 11 (38% presentaron eventos clínicos, mientras que los restantes 18 (62% no los tuvieron. Los pacientes con eventos presentaron valores del iQTc más prolongados por encima del punto de corte. En ambos grupos predominó el sexo masculino y el grupo de edad más frecuente fue el de 60 a 69 años. El tabaquismo, la hipertensión y la hipercolesterolemia fueron los más prevalentes para ambos grupos, así como el uso previo de aspirina. La estratificación de riesgo TIMI y los parámetros basales en los pacientes estudiados fueron mayores y revelan un mayor porcentaje en el grupo con eventos clínicos. Los resultados demuestran que el iQTc predice eventos adversos cardiovasculares hasta 30 días después del ingreso.

  1. Acute psychotic disorders induced by topiramate: report of two cases Episódio psicótico agudo induzido por topiramato: relato de dois casos

    Directory of Open Access Journals (Sweden)

    Florindo Stella

    2002-06-01

    Full Text Available We report on two epileptic patients who developed acute psychosis after the use of topiramate (TPM. One patient exhibited severe psychomotor agitation, heteroaggressiveness, auditory and visual hallucinations as well as severe paranoid and mystic delusions. The other patient had psychomotor agitation, depersonalization, derealization, severe anxiety and deluded that he was losing his memory. Both patients had to be taken to the casualty room. After interruption of TPM in one patient and reduction of dose in the other, a full remission of the psychotic symptoms was obtained without the need of antipsychotic drugs. Clinicians should be aware of the possibility of development of acute psychotic symptoms in patients undergoing TPM treatment.Relatamos dois pacientes epilépticos que manifestaram quadro psicótico agudo induzido por topiramato (TPM. Um paciente apresentou agitação psicomotora grave, heteroagressividade, alucinações auditivas e visuais, e delírios de conteúdo paranóide e místico. O outro paciente apresentou agitação psicomotora, despersonalização, desrealização, ansiedade intensa e delírio de que estava perdendo a memória. Ambos os pacientes foram conduzidos ao serviço de emergência e, após a interrupção do TPM em um deles e redução da droga em outro, houve remissão total dos sintomas psicóticos sem necessidade de medicação antipsicótica. Alertamos os clínicos para o risco de surgimento de sintomas psicóticos em pacientes em uso do TPM.

  2. Riesgo familiar total en salud y grado de salud familiar en las familias de los pacientes con diagnostico de síndrome coronario agudo

    Directory of Open Access Journals (Sweden)

    Ruby Elizabeth Vargas-Toloza

    2012-12-01

    Full Text Available Objetivo: identificar el riesgo familiar total en salud y grado de salud familiar en las familias de los pacientes con diagnóstico de síndrome coronario agudo de la Clínica San José de Cúcuta. Materiales y Métodos: Estudio cuantitativo, de tipo descriptivo transversal; en el que se calculó una muestra de 165 familias por muestreo no probabilístico. La recolección de la información se realizo por medio de los instrumentos RFT: 5-33 y ISF GEN-21 donde se clasifico el riesgo familiar total y se percibió el grado de salud familiar. Resultados: se evidencia que las familias están conformes con el modelo habitual de organización familiar en función de cada uno de los integrantes y del grupo como tal. Lo cual nos indica que toda la familia del paciente coronario lo ayuda a sobrellevar el proceso de salud-enfermedad y tiene claro el papel que juega dentro de ella permitiendo así la funcionalidad y la unidad que requiere este tipo de pacientes para su rehabilitación. Conclusiones: los factores de riesgo biológicos, sociales y del medio ambiente que clasifican a la población estudiada dentro de riesgo familiar bajo. Se evidenció un alto grado de organización y satisfacción asegurando en gran medida la adaptación y el éxito de las familias frente al proceso de salud- enfermedad por la que atraviesan algunos de los miembros especialmente si es un paciente coronario.

  3. Los efectos agudos de la contaminación del aire en la salud de la población: evidencias de estudios epidemiológicos

    Directory of Open Access Journals (Sweden)

    Rosales-Castillo José Alberto

    2001-01-01

    Full Text Available Objetivo. Sintetizar las evidencias de los efectos en la salud de la población por la exposición a contaminación del aire por ozono y partículas suspendidas. Material y métodos. A partir de las principales publicaciones internacionales y mexicanas, publicadas y referidas hasta junio del año 2000, se realizó un metanálisis para resumir los efectos reportados a través del empleo de modelos de efectos aleatorios. Resultados. Los resultados se expresaron como porcentajes de incremento por 10 unidades de concentración de PM10 (µg/m³ y ozono (ppb. Entre los efectos de PM10 cabe destacar el efecto agudo en la mortalidad (0.96%, hospitalizaciones (1.39%, visitas a salas de urgencias (3.11%, síntomas respiratorios (7.72%, parámetros de función pulmonar (1.42%, para capacidad vital forzada (CVF y días de actividad restringida (7.74%. Los efectos de la exposición a ozono son igualmente significativos. Conclusiones. Estos resultados muestran el gran impacto que las concentraciones de contaminantes del aire podrían tener en la salud de las poblaciones urbanas de las grandes metrópolis. El texto completo en inglés de este artículo está disponible en: http://www.insp.mx/salud/index.html

  4. Efeito agudo da imagética no desempenho de lances livres e percepção de autoeficácia em atletas

    Directory of Open Access Journals (Sweden)

    Thiago Ferreira Dias Kanthack

    2013-12-01

    Full Text Available DOI: http://dx.doi.org/10.5007/1980-0037.2014v16n1p47 O esporte cada vez mais diferencia vencedores e perdedores por mínimos detalhes. No basquetebol um fator diferenciador é o lance livre. Sessões de imagética motora (IMA vêm sendo estudada como um ergogênico sobre o desempenho de lance livre, porém, pouco se estuda o seu efeito agudo, principalmente, em atletas. O objetivo desse estudo foi verificar o efeito de uma sessão prévia de treinamento mental sobre o desempenho no lance livre e na percepção de autoeficácia de jovens atletas. Participaram do estudo 11 atletas juvenis da Federação Paulista de Basquete. Na condição IMA, foram submetidos a 1 minuto de vídeo + 3 minutos de imagética, seguidos de 10 lances livres, e no controle, 4 minutos de repouso seguidos de 10 lances livres. O questionário de autoeficácia foi preenchido antes e após a intervenção. Para análise estatística, foram utilizados os testes U de Mann-Withney, Wilcoxon e o Smallest Wothwhille Change (SWC. Não foi encontrada diferença entre a mediana dos grupos, porém, o SWC apontou uma possibilidade de 84% de efeito benéfico do treinamento mental sobre o desempenho para até 2 lances livres. Concluiu-se que a imagética motora prévia tem 84% de chance de causar um efeito benéfico sobre o desempenho de lance livre em até 2 arremessos.

  5. El estrés agudo modifica la recuperación y la extinción de la memoria espacial en función de su intensidad

    OpenAIRE

    Cuestas Diana Marcela; Troncoso Julieta

    2007-01-01

    Para evaluar los efectos del estrés agudo por restricción de movimientos sobre la recuperación y la extinción
    de la memoria espacial sin sobreentrenamiento, se utilizaron tres grupos de ratas: control, estrés una hora
    y estrés cuatro horas. Todos los animales fueron entrenados en el laberinto circular de Barnes. El protocolo
    de entrenamiento constaba de ocho ensayos de adquisición (intervalo entre ensayos, IEE; 5 min). Los animales de todos los grupos experime...

  6. Ablación miocárdica septal transluminal percutánea en pacientes con miocardiopatía hipertrófica septal obstructiva: Resultados agudos y seguimiento a 3 años

    OpenAIRE

    Llamas-Esperón,Guillermo A.; Loera Pinales,Armando; Sandoval Navarrete,Santiago; Zamora Muciño,Alberto; Ramírez Robledo,Miguel A.; Varela Ortiz,Samuel; Casas Juárez,Ulices; Fuantos Delgado,María de la Luz; Albarrán Domínguez,Javier; Muñoz Sandoval,Rocío; Sandoval Rodríguez,Eufracino; Ruiz Esparza,M. Eugenia

    2009-01-01

    Objetivo: Reportar los resultados agudos y a largo plazo de la ablación miocárdica septal transluminal percutánea (AMSTP) como tratamiento de la miocardiopatía hipertrófica septal obstructiva (MHSO). La AMSTP se considera una alternativa del tratamiento quirúrgico en pacientes con MHSO y sintomatología refractaria a otras opciones de tratamiento. La respuesta aguda suele ser satisfactoria, pero los resultados a largo plazo no se han descrito de forma suficiente. Métodos: Realizamos AMSTP en 8...

  7. Diferencias en tiempos de incapacidad según el tipo de manejo (convencional o temprano), en pacientes con dolor lumbar agudo secundario a accidentes de trabajo en una aseguradora de riesgos profesionales (ARP) de Bogotá, Colombia

    OpenAIRE

    Cortes Iza, Sandra Catalina; Espinosa Muñoz, Yiseth Andrea; Montenegro Castillo, María Juliana

    2010-01-01

    A lo largo de la historia se ha encontrado que el dolor lumbar agudo es una patología de alta prevalencia y costo, lo ha llevado a varios países a considerarlo un problema de salud pública, Sin embargo ha sido subvalorada y aun no se toman las medidas preventivas lo que aumenta los costos de atención para los servicios de salud y para las empresas es una causa importante de disminución de la producción por días de incapacidad. Con el fin de establecer si el tiempo de inicio y tipo del trat...

  8. Efectividad y seguridad de la laparotomía vs laparoscopía en abdomen agudo de origen gineco-obstétrico causado por embarazo ectópico roto y quiste de ovario roto.

    OpenAIRE

    Luna Aveiga, Cristhian

    2014-01-01

    Comparar efectividad, tiempo y sangrado operatorio, estadía y complicaciones entre laparotomía y laparoscopía en abdomen agudo (AA) por embarazo ectópico roto (EER) y quiste de ovario roto (QOR). Métodos: Estudio retrospectivo en el Hospital de Santa Elena y Clínica Granados de Enero 2010-Diciembre 2011. Se obtuvieron las causas, procedimientos, edad, hemoglobina, edad gestacional, antecedentes personales y complicaciones. Tiempo, sangrado operatorio y estadía fueron comparadas por T de stud...

  9. Vascular neurocognitive disorders and the vascular risk factors

    Directory of Open Access Journals (Sweden)

    Carmen V. Albu

    2018-04-01

    Full Text Available Dementias are clinical neurodegenerative diseases characterized by permanent and progressive transformation of cognitive functions such as memory, learning capacity, attention, thinking, language, passing judgments, calculation or orientation. Dementias represent a relatively frequent pathology, encountered at about 10% of the population of 65-year olds and 20% of the population of 80-year olds. This review presents the main etiological forms of dementia, which include Alzheimer form of dementia, vascular dementia, dementia associated with alpha-synucleionopathies, and mixed forms. Regarding vascular dementia, the risk factors are similar to those for an ischemic or hemorrhagic cerebrovascular accident: arterial hypertension, diabetes mellitus, dyslipidemia, smoking, obesity, age, alcohol consumption, cerebral atherosclerosis/ arteriosclerosis. Several studies show that efficient management of the vascular risk factors can prevent the expression and/ or progression of dementia. Thus, lifestyle changes such as stress reduction, regular physical exercise, decreasing dietary fat, multivitamin supplementation, adequate control of blood pressure and serum cholesterol, and social integration and mental stimulation in the elderly population are important factors in preventing or limiting the symptoms of dementia, a disease with significant individual, social, and economic implications.

  10. Regarding the rejection performance of a polymeric reverse osmosis membrane for the final purification of two-phase olive mill effluents previously treated by an advanced oxidation process; Sobre la eficiencia del rechazo de una membrana polimérica de ósmosis inversa para la purificación del agua residual de almazara de dos fases, previamente tratada mediante un proceso avanzado de oxidación

    Energy Technology Data Exchange (ETDEWEB)

    Ochando-Pulido, J.M.; Martínez-Férez, A.

    2017-07-01

    In previous works on olive mill wastewater (OMW), secondary advanced oxidation treatment solved the problem related to the presence of phenolic compounds and considerable chemical oxygen demand. However, the effluent presented a significant salinity after this treatment. In this work, an adequate operation of a reverse osmosis (RO) membrane is addressed to ensure constant performance over a long period of time. In this paper, the effect of the operating parameters on the dynamic membrane rejection performance towards the target species was examined and discussed. Rejection efficiencies of all species were observed to follow a similar pattern, which consisted of slight initial improvement that further decreased over time. Rejection of both divalent ions remained constant at over 99% regardless of the operating conditions. Rejections were noticed to follow the order SO42−> Cl−> NO3− and Ca2+> Mg2+> K+> Na+, as a rule. Divalent species were moderately more highly rejected than monovalent ones, in accordance with their higher charge and molecular size, and sulfate anions were consistently rejected by over 99%. Finally, the RO membrane exiting treated effluent was depleted of the high electro conductivity initially present (above 97% rejection), permitting its re-use as good quality irrigation water (below 1 mS/cm). [Spanish] En trabajos previos con agua residual de almazara, se solucionó el problema en relación a la presencia de compuestos fenólicos y la considerable concentración de material orgánico. Sin embargo, el efluente presentaba una salinidad significativa tras éste. Este trabajo tiene por objetivo estudiar la adecuada operación de una membrana de ósmosis inversa (OI) para asegurar rendimientos constantes por largos períodos de tiempo de operación. Se examina y discute el efecto de los parámetros de operación en el rendimiento dinámico del rechazo de especies diana. Se observó que la eficiencia de rechazo de todas las especies siguió un

  11. Vascularized osseous graft for scaphoid

    International Nuclear Information System (INIS)

    Mendez Daza, Carlos Hernan; Mathoulin, Cristophe

    2004-01-01

    The most commonly used technique for treatment of pseudo-arthrosis of the scaphoid is osteo-synthesis with Kirschnet wires and cortical sponge grafts. Results reported by different teams using this procedure show no more than 90% osseous consolidation, especially in cases where vascularisation of the proximal fragment of the scaphoid is compromised. Here we present a series of ten cases of pseudo-arthrosis of the scaphoid, treated using a new surgical technique involving a vascularized osseous graft of the distal radius. Using this procedure we obtained 100% consolidation, with no complications either during the procedure or immediately post-operatively. Patients returned to work in week 15 on average. In 4 cases we observed discomfort in the area of the scar, which was successfully treated using local cortisone injection. The results obtained are very similar to those seen in the literature on the different techniques for vascularized osseous grafts for pseudo-arthrosis of the scaphoid

  12. [Menopause: Hypertension and vascular disease].

    Science.gov (United States)

    Zilberman, J M

    Hypertension is the main cardiovascular risk factor affecting 25% of women. Hormone changes and hypertension after menopause may lead to higher target organ damage and cardiovascular disease such as increased arterial stiffness, coronary diseases, chronic heart failure and stroke. The physiopathological mechanisms involved in the development of hypertension and cardiovascular diseases in menopausal women are controversial. There are pharmacokinetic and pharmacodynamic differences in both sexes, the women have more coughing when using the converting-enzyme inhibitors, more cramps when using thiazide diuretics and more oedema in the inferior limbs when using calcium antagonists. The aim of this review is to analyse possible physiopathological mechanisms involved in hypertension after menopause and to gain a better understanding of the biological effects mediated by vascular ageing in women when the level of oestrogen protective effect decreases over the vascular system. Copyright © 2017 SEH-LELHA. Publicado por Elsevier España, S.L.U. All rights reserved.

  13. Vascular diagnostics for Raynaud's phenomenon

    Directory of Open Access Journals (Sweden)

    Dinsdale G

    2014-10-01

    Full Text Available Graham Dinsdale, Ariane L Herrick Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Salford Royal NHS Foundation Trust, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK Abstract: Raynaud's phenomenon (RP is common, and in most patients is primary (idiopathic when due to reversible vasospasm and does not progress to irreversible tissue injury. However, in those patients for whom RP is secondary to an underlying disease (eg, systemic sclerosis or atherosclerosis, progression to digital ulceration or critical ischemia can occur. Therefore, the key question for the clinician is “Why does this patient have RP?” Vascular diagnostics play a key role in answering this. In this review, we firstly discuss the different vascular investigations relevant to clinical practice: nail fold capillaroscopy (including the different methodologies for examining the nail fold capillaries, and the role of capillaroscopy in helping to differentiate between primary and systemic sclerosis-related RP, thermography (available in specialist centers, and evaluation of large vessel disease (for example, due to atherosclerosis. We then discuss research tools, mainly laser Doppler methods, including laser Doppler imaging and laser speckle contrast imaging. These are commercially available as complete imaging systems and are (relatively easy to use. The main current goal in vascular imaging research is to validate these novel state-of-the-art techniques as outcome measures of digital vascular disease, and then apply them in early and later phase studies of new treatment approaches, thus facilitating drug development programs. Keywords: Raynaud's phenomenon, systemic sclerosis, nail fold capillaroscopy, thermography, laser Doppler, angiography

  14. Cardiomiopatia de Takotsubo: uma causa rara de choque cardiogênico simulando infarto agudo do miocárdio Takotsubo cardiomiopathy: a rare cause of cardiogenic shock simulating acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Jayro Thadeu Paiva de Vasconcelos

    2005-08-01

    Full Text Available Cardiomiopatia de Takotsubo é uma causa rara de aneurisma ventricular esquerdo agudo, na ausência de coronariopatia, só recentemente descrita na literatura mundial. Os sintomas podem assemelhar-se aos do infarto agudo do miocárdio com dor torácica típica. A imagem do balonamento ventricular sugestivo de haltere ou "Takotsubo" (dispositivo utilizado no Japão para prender Octopus é característico desta nova síndrome e usualmente há desaparecimento do movimento discinético até o 18º dia do início dos sintomas, em média.Takotsubo Cardiomiopathy is a rare cause of acute left ventricular aneurysm, in the absence of coronariopathy, only recently described in world literature. Symptoms may be similar to those from acute myocardial infarction with typical thoracic pain. The image of dumbbell or Takotsubo (a device used in Japan to capture octopus suggestive ventricular ballooning is characteristic of that new syndrome and there is usually the disappearing of dyskinetic movement up to the 18th day from the beginning of the symptoms, in average.

  15. Apendicitis epiploica. Causa poco común de abdomen agudo en niños. Presentación de un caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    SA Solórzano-Morales

    2016-04-01

    requiere tratamiento con analgésicos. La mayoría de los casos han sido descritos en pacientes adultos; sin embargo, el caso que presentamos es el segundo diagnosticado en el Instituto Nacional de Pediatría.   CASO CLÍNICO: niño de 9 años con diagnóstico clínico presuntivo de apendicitis, se diagnosticó por ultrasonido y tomografía computada como apendicitis epiploica, lo que se corroboró en la pieza anatomopatológica.   CONCLUSIONES: nuestro propósito es describir la apendicitis epiploica en niños como causa de abdomen agudo, así como los hallazgos clínicos, ultrasonográficos, de tomografía computada e histopatológicos de esta patología como causa rara de abdomen agudo. Es importante que se conozca el valor de los estudios de imagen de esta entidad a fin de evitar tratamientos invasivos innecesarios.

  16. Escore TIMI no infarto agudo do miocárdio conforme níveis de estratificação de prognóstico Score TIMI en el infarto agudo de miocardio según niveles de estratificación de pronóstico TIMI risk score for acute myocardial infarction according to prognostic stratification

    Directory of Open Access Journals (Sweden)

    Jaqueline Locks Pereira

    2009-08-01

    Full Text Available FUNDAMENTO: O escore de risco TIMI (thrombolysis in myocardial infarction é derivado de ensaio clínico envolvendo pacientes elegíveis para fibrinólise. Como o perfil de risco desses casos difere do encontrado em populações não selecionadas, é importante que se analise a aplicabilidade do escore em condições clínicas habituais. OBJETIVO: Avaliar o manejo e a evolução hospitalar de pacientes internados com infarto agudo do miocárdio conforme estratificação de risco pelo escore TIMI. MÉTODOS: Foram avaliados, retrospectivamente, 103 casos de infarto agudo do miocárdio com supradesnivelamento do segmento ST, admitidos no Hospital Nossa Senhora da Conceição, em Tubarão, nos anos de 2004 e 2005. Os casos foram analisados em três grupos de risco de acordo com o escore TIMI. RESULTADOS: A mortalidade hospitalar pós-infarto foi de 17,5%. No grupo de baixo risco não houve óbito. A mortalidade foi de 8,1% no grupo de médio risco e de 55,6% no de alto risco. O risco de morte para casos de alto risco foi 14,1 vezes maior em relação aos casos de médio e baixo risco (IC95% = 4,4 a 44,1 e pFUNDAMENTO: El score de riesgo TIMI (thrombolysis in myocardial infarction se derivó de ensayo clínico que implicó a pacientes elegibles para fibrinólisis. Como el perfil de riesgo de esos casos difiere del encontrado en poblaciones no seleccionadas, es importante que se analice la aplicabilidad del score en condiciones clínicas habituales. OBJETIVO: Evaluar el manejo y la evolución hospitalaria de pacientes internados con infarto agudo de miocardio de acuerdo con la estratificación de riesgo mediante la puntuación TIMI. MÉTODOS: Se evaluaron, retrospectivamente, 103 casos de infarto agudo de miocardio con supradesnivelamiento del segmento ST, ingresados en el Hospital Nossa Senhora da Conceição, en Tubarão, en los años de 2004 y 2005. Se analizaron los casos en tres grupos de riesgo según el score TIMI. RESULTADOS: La mortalidad

  17. Ghrelin improves vascular autophagy in rats with vascular calcification.

    Science.gov (United States)

    Xu, Mingming; Liu, Lin; Song, Chenfang; Chen, Wei; Gui, Shuyan

    2017-06-15

    This study aimed to investigate whether ghrelin ameliorated vascular calcification (VC) through improving autophagy. VC model was induced by nicotine plus vitamin D 3 in rats and β-glycerophosphate in vascular smooth muscle cell (VSMC). Calcium deposition was detected by von Kossa staining or alizarin red S staining. ALP activity was also detected. Western blot was used to assess the protein expression. Ghrelin treatment attenuated the elevation of calcium deposition and ALP activity in VC model both in vivo and in vitro. Interesting, the protein levels of autophagy markers, LC3 and beclin1 were significantly upregulated by ghrelin in VC model. An autophagy inhibitor, 3-methyladenine blocks the ameliorative effect of ghrelin on VC. Furthermore, protein expressions of phosphate-AMPK were increased by ghrelin treatment both in calcified aorta and VSMC. The effect of ghrelin on autophagy induction and VC attenuation was prevented by AMPK inhibitor, compound C. Our results suggested that ghrelin improved autophagy through AMPK activation, which was resulted in VC amelioration. These data maybe throw light on prevention and therapy of VC. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. A diferenciação da dor do infarto agudo do miocárdio entre pacientes diabéticos e não-diabéticos Diferenciación del dolor del infarto agudo de miocardio entre pacientes diabéticos y no diabéticos The difference in acute myocardial infarction pain between diabetic and non diabetic patients

    Directory of Open Access Journals (Sweden)

    Leandra de Gouveia Pacheco Gondim

    2003-12-01

    Full Text Available O estudo teve como objetivo comparar a dor do infarto agudo do miocárdio (IAM entre pacientes diabéticos e não-diabéticos. Uma amostra de 80 pacientes com IAM, divididos em 2 grupos com e sem diabetes mellitus (DM, sendo 29% diabéticos e 71% não-diabéticos. Os pacientes com DM referiram ausência de dor (pEl objetivo de este estudio fue comparar el dolor del infarto agudo de miocardio (IAM entre pacientes diabéticos y no diabéticos. La muestra la conformaron 80 pacientes con IAM divididos en dos grupos: con y sin diabetes mellitus (DM, siendo el 29% diabéticos y el 71% no diabéticos. Los pacientes con DM manifestaron ausencia de dolor (pThe goal of this study was to compare the acute myocardial infarction (AMI pain between diabetic and non diabetic patients. A sample of 80 AMI patients was divided in two groups, with and without diabetes mellitus (DM, being 29% diabetic and 71% non diabetic patients. The patients with DM said they had no pain (p<0.05 and gave lower scores for pain when compared with patients without DM. There was a significant difference between average scores for pain among diabetic and non diabetic patients (p<0.001. In conclusion, the diabetic patients presented no pain or diminished pain when compared with patients without diabetes.

  19. Vascular dementia: Facts and controversies

    Directory of Open Access Journals (Sweden)

    Pavlović Aleksandra

    2013-01-01

    Full Text Available Vascular dementia (VaD is the second most frequent dementia after Alzheimer’s disease, and is diagnosed during lifetime in 20% of demented patients. Five­year survival rate in VaD is 39%, while it is estimated to be 75% in healthy persons of the same age. It is therefore important to make correct diagnosis of VaD early in the course of the disease. Risk factors for VaD are identical to stroke risk factors, and there are significant possibilities for the prevention of vascular cognitive decline. Cognitive decline develops acutely or step­by­step within three months after stroke, but more gradual progression of intellectual decline is also possible. Neurological examination can reveal pyramidal and extrapyramidal signs, pseudobulbar palsy, gait disturbance and urinary incontinence. Neuropsychological profile comprises the loss of cognitive set shifting, decline in word fluency, verbal learning difficulties, perseverations, difficulties in complex figure copying, and in patients with cortically located lesions also problems with speech and praxia. The basis of the diagnosis is, besides history, neurological examination and neuropsychological assessment, computed tomography and/ or magnetic resonance brain imaging. Vascular risk factors control is the most important measure in VaD prevention. Modern guidelines for the treatment of cognitive decline in VaD emphasize that donepezil can be useful in the improvement of cognitive status at the level of Class IIa recommendation at the level of evidence A, while memantine may be useful in patients with mixed VaD and Alzheimer’s disease dementia. [Projekat Ministarstva nauke Republike Srbije, br. 175022 i br. 175033

  20. EL ESTRÉS AGUDO INTERFIERE CON LA EVOCACIÓN Y PROMUEVE LA EXTINCIÓN DE LA MEMORIA ESPACIAL EN EL LABERINTO DE BARNES

    Directory of Open Access Journals (Sweden)

    Julieta Troncoso

    2010-01-01

    Full Text Available Para evaluar los efectos del estrés agudo sobre la recuperación y la extinción de la memoria espacial, se utilizaron ratas entrenadas en el laberinto circular de Barnes. El entrenamiento consistió de 8 ensayos de adquisición (intervalo entre ensayos, IEE, de 5 min en donde los animales debían aprender a encontrar una caja meta ubicada en uno de los 18 agujeros del laberinto. Todos los animales adquirieron el aprendizaje espacial, ya que invirtieron menos tiempo en encontrar la caja meta y cometieron menos errores a medida que se sucedían los ensayos de entrenamiento. Veinticuatro horas después del entrenamiento se evaluó la retención y extinción del aprendizaje espacial mediante una prueba con caja meta (PCC seguida de siete pruebas sin caja (PSC, con un IEE de 5 min. Una hora y media antes de la sesión de evaluación de la memoria un grupo de animales fue sometido a estrés por restricción de movimientos durante una hora, permitiéndoles un período de recuperación de 30 min y otro grupo permaneció en su caja hogar sin manipulación (control. Los resultados indican que el estrés deteriora el proceso de evocación de la memoria espacial, ya que los animales estresados cometieron un mayor número de errores y demoraron más tiempo en encontrar la caja meta durante la PCC, respecto de los controles. Además, el estrés facilita el proceso de extinción, ya que, durante las PSCs los animales estresados no mostraron una persistencia en la exploración del agujero que, en el entrenamiento, conducía a la caja meta.

  1. Efeitos agudos de diferentes métodos de treinamento com pesos sobre o gasto energético em homens treinados

    Directory of Open Access Journals (Sweden)

    Rodrigo Ramalho Aniceto

    2013-06-01

    Full Text Available INTRODUÇÃO: O treinamento com pesos vem sendo amplamente utilizado como estratégia de controle e redução ponderal, assim o gasto energético (GE contribui de forma significativa para este processo. OBJETIVO: Comparar os efeitos agudos do método circuito (MC com o método tradicional (MT sobre o GE. MÉTODOS: Trata-se de uma pesquisa com delineamento crossover e aleatorizado, a amostra foi composta por 10 homens adultos treinados com idade entre 18 e 29 anos. Foram realizadas duas sessões experimentais com wash out de sete dias: no MC os exercícios foram realizados alternados por segmento em forma de estações, durante o MT os exercícios foram realizados em séries consecutivas. Ambos os métodos seguiram a mesma sequência de oito exercícios com o mesmo trabalho total: 60% de 1RM, 24 séries/estações e 10 repetições. O lactato sanguíneo foi coletado em repouso e a cada três séries/estações. O ar expirado foi coletado por 30 minutos antes e ~31 minutos durante todas as sessões de treinamento. O GE aeróbio de exercício (GEAE, kj e do intervalo de recuperação (GEAIR, kj foram estimados pela calorimetria indireta através da medida do consumo de oxigênio e o GE anaeróbio (GEA, kj pela concentração de lactato sanguíneo ([La]. O GE total (GET, kj foi registrado pelo somatório do GEA, GEAE e GEAIR. RESULTADOS: Os dados demonstraram que o GEA foi maior no MT do que o MC, no entanto, o GEAE, GEAIR e o GET não foram diferentes significativamente entre os métodos. O MT apresentou maior [La] do que o MC. CONCLUSÃO: Conclui-se que o MC e o MT produzem similar GET, contudo, percebe-se que o MT utiliza mais a via anaeróbia do que o MC.

  2. Modelo experimental de trauma medular agudo produzido por aparelho estereotáxico modificado Experimental model of acute spinal cord injury produced by modified steriotaxic equipment

    Directory of Open Access Journals (Sweden)

    B.B.J. Torres

    2010-02-01

    Full Text Available Foram utilizados 55 ratos machos da espécie Rattus novergicus, variedade Wistar, com o objetivo de propor um modelo experimental de trauma medular produzido por aparelho estereotáxico modificado, capaz de reproduzir clinicamente lesões medulares padronizadas. Após realização de laminectomia dorsal de T13, utilizou-se peso compressivo de 50,5g (25 animais - grupo I ou 70,5g (30 animais - grupo II, durante cinco minutos, comprimindo a medula espinhal. Os animais foram assistidos durante oito dias, por meio de testes comportamentais para avaliar a sensibilidade dolorosa, a capacidade motora, o posicionamento tátil e proprioceptivo e a capacidade de manter-se em plano inclinado. No grupo I, observaram-se déficits neurológicos moderados e transitórios, que variaram entre os animais. No grupo II, foi possível obter um trauma padronizado, caracterizado por paraplegia bilateral e simétrica dos membros posteriores, perda de propriocepção e da sensibilidade dolorosa de todos os animais. A utilização do aparelho estereotáxico desenvolvido permite reproduzir clinicamente trauma medular padronizado em ratos, de maneira simples, econômica e satisfatória, o que poderá proporcionar avanços nas investigações terapêuticas, abrangendo doenças neurodegenerativas, como é o caso do trauma medular agudo.Fifty-five male rats (Rattus novergicus, Wistar variety, were used with the purpose of suggesting an experimental model of spinal cord trauma performed by using a modified stereotaxic equipment capable to reproduce clinically (standardized pattern spinal cord injury. After dorsal laminectomy of T13, a compression was performed with 50.5g (25 animals - group I or 70.5g (30 animals - group II during five minutes on spinal cord. The animals were assisted during eight days by behavioral tests to evaluate painful sensibility, motor capacity, proprioceptive and tactil placing, and stability on inclined plan. In the group I, moderate and transitory

  3. ANESTESIA PARA AMPUTACIÓN SUPRACONDÍLEA EN PACIENTE CON SÍNDROME CORONARIO AGUDO / Anesthesia for supracondylar amputation in patient with acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Marilyn Ramírez Méndez

    2012-03-01

    Full Text Available Resumen La insuficiencia arterial periférica es una enfermedad que se asocia a factores de riesgo aterogénico reconocidos, y es más frecuente en personas con hiperlipidemia, diabetes mellitus y hábito de fumar. Se presenta el caso de una mujer de 67 años de edad, con antecedentes de hipertensión arterial, diabetes mellitus e infarto de miocardio antiguo, que ingresa por signos de inflamación aguda del miembro inferior derecho como consecuencia de una insuficiencia arterial periférica. A los 8 días del ingreso presentó un síndrome coronario agudo sin elevación del segmento ST, con fallo de bomba Killip II, y una vez compensada fue anunciada para amputación supracondílea de urgencia, debido a una gangrena isquémica. Se decidió utilizar anestesia espinal subaracnoidea selectiva del miembro inferior derecho, a cual se aplicó sin complicaciones y favoreció el adecuado desarrollo de la cirugía planificada. A las 72 horas la paciente fue egresada de la UCI, sin síntomas cardiovasculares y compensación metabólica. / Abstract Peripheral arterial insufficiency is a disease that is associated with known atherogenic risk factors, and is more common in people with hyperlipidemia, diabetes mellitus and smoking habit. A case of a 67-year-old woman with a history of hypertension, diabetes mellitus and old myocardial infarction is presented. She was admitted for signs of acute inflammation of the right leg due to peripheral arterial insufficiency. 8 days after admission she presented an acute coronary syndrome without ST segment elevation with pump failure (Killip class II, and once compensated she was scheduled for emergency supracondylar amputation due to ischemic gangrene. It was decided to use selective spinal subarachnoid from the right leg, which was applied without complications and favored the proper development of the planned surgery. At 72 hours, the patient was discharged from the ICU, with metabolic compensation and without

  4. Efeito agudo dos extensores do joelho unilateral na cadeira extensora com e sem estímulos na plataforma vibratória

    Directory of Open Access Journals (Sweden)

    Fernando Roberto Ferreira

    2013-10-01

    Full Text Available INTRODUÇÃO: Nos últimos anos muitos estudos foram feitos com o objetivo de avaliar a utilização da vibração mecânica como parte de treinamento para melhora do condicionamento físico. Entretanto, a maioria avaliou os efeitos dos exercícios em conjunto com o treinamento vibratório para determinar se havia melhora após o treinamento, sem avaliar os efeitos dos exercícios realizados na plataforma com e sem vibração. OBJETIVO: Avaliar o efeito agudo do exercício nos extensores do joelho, com e sem o estímulo da plataforma vibratória. MÉTODOS: Trinta indivíduos ativos, do sexo masculino, com idades entre 18 e 45 anos, realizaram, de forma randomizada, três protocolos: grupo plataforma ligada (GPL, grupo plataforma desligada (GPD e grupo controle (GC. Cada protocolo começava com aquecimento de cinco minutos em bicicleta ergométrica, com carga entre 75 e 100 watts e 70 rotações por minuto, seguido por seis séries de 10 movimentos de agachamento unilateral com intervalo de um minuto entre elas, com ou sem vibração mecânica, e terminava com o Work Test, realizado apenas no membro inferior dominante para determinação das valências físicas: trabalho, força, potência e velocidade. O grupo controle realizou apenas o Work Test após o aquecimento. RESULTADOS: Apenas a variável velocidade apresentou diferença estatisticamente significante (p < 0,05 quando comparado o GPL ao GC. CONCLUSÃO: O estímulo na plataforma vibratória não exerceu influência nas variáveis trabalho e potência dos extensores do joelho unilateral, mas, na velocidade do movimento, exerceu influência negativa causando fadiga.

  5. Implantação da linha de cuidado do infarto agudo do miocárdio no município de Belo Horizonte

    Directory of Open Access Journals (Sweden)

    Milena Soriano Marcolino

    2013-04-01

    Full Text Available FUNDAMENTO: A criação de sistemas ou linhas de cuidado ao infarto agudo do miocárdio (IAM tem o objetivo de otimizar o atendimento ao paciente, desde o diagnóstico precoce até o tratamento adequado e em tempo hábil. OBJETIVO: Avaliar a implantação da linha de cuidado do IAM, em Belo Horizonte, Minas Gerais, e seu impacto na mortalidade hospitalar por IAM. MÉTODOS: A linha de cuidado do IAM foi implantada em Belo Horizonte entre 2010 e 2011 com intuito de ampliar o acesso dos pacientes do sistema público de saúde ao tratamento preconizado pelas diretrizes vigentes. As equipes das unidades de pronto atendimento foram treinadas e foi implantado sistema de tele-eletrocardiografia nessas unidades. Os desfechos primários deste estudo observacional retrospectivo foram o número de internações e a mortalidade hospitalar por IAM, de 2009 a 2011. RESULTADOS: No período avaliado, 294 profissionais foram treinados e 563 ECGs foram transmitidos das unidades de pronto atendimento para as unidades coronarianas. Houve redução importante da taxa de mortalidade hospitalar (12,3% em 2009 versus 7,1% em 2011, p < 0,001, enquanto o número de internações por IAM permaneceu estável. Ocorreu aumento do custo médio de internação (média R$ 2.480,00 versus R$ 3.501,00, p < 0,001, aumento da proporção de internações contemplando diárias de terapia intensiva (32,4% em 2009 versus 66,1% em 2011, p < 0,001 e de pacientes internados em hospitais de alta complexidade (47,0% versus 69,6%, p < 0,001. CONCLUSÃO: A implantação da linha de cuidado do IAM permitiu maior acesso da população ao tratamento adequado e, consequentemente, redução na mortalidade hospitalar por IAM.

  6. Efeitos agudos no desempenho do salto vertical após o agachamento com banda elástica de joelho

    Directory of Open Access Journals (Sweden)

    Willy Andrade Gomes

    2015-08-01

    Full Text Available INTRODUÇÃO: A banda elástica pode afetar o desempenho durante exercícios de alta intensidade, reduzindo a ativação muscular, o que pode influenciar o efeito de potencialização pós-ativação, que depende de alta intensidade para o exercício subsequente que visa potência. Objetivo: Verificar os efeitos agudos no desempenho do salto com contramovimento (SCM após o agachamento em alta intensidade com e sem o uso da banda elástica de joelhos em sujeitos treinados em força.MÉTODOS: Participaram do estudo 14 homens (idade: 24 ± 4 anos, estatura: 176 ± 6 cm, massa corporal: 81 ± 11 kg, 1RM: 107 ± 30 kgf, treinados em força (>3 anos. Foram realizados três SCM antes e após três meio-agachamentos a 90% de 1RM nas condições com e sem a banda elástica de joelhos. Durante o SCM foram avaliados ativação muscular (IEMG do vasto lateral (VL, glúteo máximo (GM, tempo de salto (TS e impulso (IMP por meio da força vertical de reação do solo (FRSv.RESULTADOS: Os resultados mostraram que para o TS foi verificada diferença significante entre as condições pós-meio-agachamento (com e sem banda (P= 0,044, TE = 1,02, sendo que os maiores valores foram observados para a condição sem banda. Para a IEMG de VL foi verificada diferença significante entre as condições pré e pós o meio-agachamento (com banda (P= 0,029, TE = 1,68, sendo que os maiores valores foram observados para a IEMG com banda. Para a IEMG de GM e para o IMP não foram verificadas diferenças significantes entre as condições.CONCLUSÃO: Após a utilização da banda elástica de joelhos durante o exercício agachamento, ocorreu uma redução na participação do vasto lateral durante o salto com contramovimento, afetando o tempo de contato, mas não a produção de impulso, e consequente desempenho.

  7. Tratamiento del episodio agudo de asma bronquial en los servicios de urgencias pediátricos: Guía clínica práctica Treatment of the acute episode of bronchial asthma at the pediatric emergency services: Practical clinical guide

    Directory of Open Access Journals (Sweden)

    Roberto Razón Behar

    2005-12-01

    Full Text Available Por lo general, no existe una sistematización para clasificar y tratar el episodio agudo de asma bronquial ni para evaluar la evolución de los pacientes. Se realizó un estudio en 142 pacientes de 6 a 15 años de edad, que presentaron episodios agudos de asma bronquial y acudieron a los servicios de urgencias de los Hospitales Pediátricos «William Soler» y «Leonor Pérez», y del Policlínico «Federico Capdevila». A estos pacientes se les aplicó una guía clínica práctica, que incluyó la clasificación de la severidad del episodio agudo y un esquema de tratamiento, basado en la utilización de oxígeno, broncodilatadores inhalados y esteroides orales. Durante el tratamiento, los pacientes se evaluaron con periodicidad. La respuesta al tratamiento fue buena en la mayoría de los casos y el resultado final fue el egreso domiciliario. Ocho de los pacientes requirieron ingreso hospitalario por respuestas al tratamiento incompletas o pobres. La atención del episodio agudo de asma bronquial puede mejorarse con el uso de guías clínicas prácticas de diagnóstico y tratamiento.

  8. Non-vascular surgical mediastinum

    International Nuclear Information System (INIS)

    Schiavon, S.; Trenaghi, P.; Nardini, S.; Pagan, V.

    1989-01-01

    A review was made of the chest X-ray features of 120 patients who underwent surgical treatment for mediastinal non-vascular pathologies over the past 12 years in the Mestre Hospital. A method of analysis is proposed which takes into account not only the differences between the immediate post-operative period and the follow-up, but also the anatomotopographic partition and the surgical practice. Normal and pathological patterns for both of the above periods are described. The ''dimness'' of the arial tracheogram is emphasized as a usefull and early sign of mediastinal recurrence

  9. Vascular comorbidities in multiple sclerosis

    DEFF Research Database (Denmark)

    Thormann, Anja; Magyari, Melinda; Koch-Henriksen, Nils

    2016-01-01

    To investigate the occurrence of vascular comorbidities before and after the clinical onset of multiple sclerosis. In this combined case-control and cohort study, all Danish born citizens with onset of multiple sclerosis 1980-2005 were identified from the Danish Multiple Sclerosis Registry...... and randomly matched with controls regarding year of birth, gender, and municipality on January 1st in the year of multiple sclerosis (MS) onset (index date). Individual-level information on comorbidities was obtained from several independent nationwide registries and linked to the study population by unique...

  10. Heritability of Retinal Vascular Fractals

    DEFF Research Database (Denmark)

    Vergmann, Anna Stage; Broe, Rebecca; Kessel, Line

    2017-01-01

    , the retinal vascular fractal dimension was measured using the box-counting method and compared within monozygotic and dizygotic twin pairs using Pearson correlation coefficients. Falconer's formula and quantitative genetic models were used to determine the genetic component of variation. Results: The mean...... fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, P = 0...

  11. O efeito agudo do chocolate amargo sob a função endotelial é dependente da idade em hipertensos com baixo risco cardiovascular

    OpenAIRE

    Jenifer Palma dEl-Rei Pinto

    2011-01-01

    Dados recentes indicam uma relação inversa entre doença cardiovascular e consumo de flavonóides. O objetivo do estudo foi identificar parâmetros clínicos e vasculares de pacientes hipertensos tratados que apresentaram efeitos benéficos na função vascular após o consumo de chocolate amargo com 70% de cacau por sete dias. Vinte e um pacientes hipertensos em tratamento medicamentoso, ambos os sexos, com idades entre 40-65 anos, foram incluídos em um ensaio clínico intervencional com aferição de...

  12. CIRSE Vascular Closure Device Registry

    International Nuclear Information System (INIS)

    Reekers, Jim A.; Müller-Hülsbeck, Stefan; Libicher, Martin; Atar, Eli; Trentmann, Jens; Goffette, Pierre; Borggrefe, Jan; Zeleňák, Kamil; Hooijboer, Pieter; Belli, Anna-Maria

    2011-01-01

    Purpose: Vascular closure devices are routinely used after many vascular interventional radiology procedures. However, there have been no major multicenter studies to assess the safety and effectiveness of the routine use of closure devices in interventional radiology. Methods: The CIRSE registry of closure devices with an anchor and a plug started in January 2009 and ended in August 2009. A total of 1,107 patients were included in the registry. Results: Deployment success was 97.2%. Deployment failure specified to access type was 8.8% [95% confidence interval (95% CI) 5.0–14.5] for antegrade access and 1.8% (95% CI 1.1–2.9) for retrograde access (P = 0.001). There was no difference in deployment failure related to local PVD at the access site. Calcification was a reason for deployment failure in only 5.9 cm, and two vessel occlusions. Conclusion: The conclusion of this registry of closure devices with an anchor and a plug is that the use of this device in interventional radiology procedures is safe, with a low incidence of serious access site complications. There seems to be no difference in complications between antegrade and retrograde access and other parameters.

  13. Neuroradiological findings in vascular dementia

    Energy Technology Data Exchange (ETDEWEB)

    Guermazi, Ali; Miaux, Yves; Suhy, Joyce; Pauls, Jon; Lopez, Ria [Synarc, Inc., Department of Radiology Services, San Francisco, CA (United States); Rovira-Canellas, Alex [Hospital General Universitari Vall d' Hebron, Unita de Resonancia Magnetica, Barcelona (Spain); Posner, Holly [Eisai, Inc., Teaneck, NJ (United States)

    2007-01-15

    There are multiple diagnostic criteria for vascular dementia (VaD) that may define different populations. Utilizing the criteria of the National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et l'Enseignement en Neurosciences (NINDS-AIREN) has provided improved consistency in the diagnosis of VaD. The criteria include a table listing brain imaging lesions associated with VaD. The different neuroradiological aspects of the criteria are reviewed based on the imaging data from an ongoing large-scale clinical trial testing a new treatment for VaD. The NINDS-AIREN criteria were applied by a centralized imaging rater to determine eligibility for enrollment in 1,202 patients using brain CT or MRI. Based on the above data set, the neuroradiological features that are associated with VaD and that can result from cerebral small-vessel disease with extensive leukoencephalopathy or lacunae (basal ganglia or frontal white matter), or may be the consequence of single strategically located infarcts or multiple infarcts in large-vessel territories, are illustrated. These features may also be the consequence of global cerebral hypoperfusion, intracerebral hemorrhage, or other mechanisms such as genetically determined arteriopathies. Neuroimaging confirmation of cerebrovascular disease in VaD provides information about the topography and severity of vascular lesions. Neuroimaging may also assist with the differential diagnosis of dementia associated with normal pressure hydrocephalus, chronic subdural hematoma, arteriovenous malformation or tumoral diseases. (orig.)

  14. Diffuse and vascular hepatic diseases

    International Nuclear Information System (INIS)

    Kreimeyer, S.; Grenacher, L.

    2011-01-01

    In addition to focal liver lesions, diffuse and vascular disorders of the liver represent a wide spectrum of liver diseases which are from the radiological point of view often difficult or nearly impossible to diagnose. Classical diagnostic methods are computed tomography and magnetic resonance imaging in addition to ultrasound. Diffuse parenchymal damage caused by diseases of various etiologies is therefore difficult to evaluate because it often lacks characteristic morphological features. For hepatic steatosis, hemochromatosis/siderosis as an example of a diffuse storage disease and sarcoidosis and candidiasis as infectious/inflammatory diseases, an image-based diagnosis is appropriate in some cases. For most diffuse liver diseases, however only nonspecific changes are visualized. Vascular pathologies of the liver, such as the Budd-Chiari syndrome and portal vein thrombosis, however, can usually be diagnosed very clearly using radiology and there is also a very effective interventional radiological treatment. Chronic diseases very often culminate in liver cirrhosis which is highly associated with an increased risk of liver cancer. (orig.) [de

  15. CIRSE Vascular Closure Device Registry

    Science.gov (United States)

    Müller-Hülsbeck, Stefan; Libicher, Martin; Atar, Eli; Trentmann, Jens; Goffette, Pierre; Borggrefe, Jan; Zeleňák, Kamil; Hooijboer, Pieter; Belli, Anna-Maria

    2010-01-01

    Purpose Vascular closure devices are routinely used after many vascular interventional radiology procedures. However, there have been no major multicenter studies to assess the safety and effectiveness of the routine use of closure devices in interventional radiology. Methods The CIRSE registry of closure devices with an anchor and a plug started in January 2009 and ended in August 2009. A total of 1,107 patients were included in the registry. Results Deployment success was 97.2%. Deployment failure specified to access type was 8.8% [95% confidence interval (95% CI) 5.0–14.5] for antegrade access and 1.8% (95% CI 1.1–2.9) for retrograde access (P = 0.001). There was no difference in deployment failure related to local PVD at the access site. Calcification was a reason for deployment failure in only 5.9 cm, and two vessel occlusions. Conclusion The conclusion of this registry of closure devices with an anchor and a plug is that the use of this device in interventional radiology procedures is safe, with a low incidence of serious access site complications. There seems to be no difference in complications between antegrade and retrograde access and other parameters. PMID:20981425

  16. Enhanced Recovery after Vascular Surgery

    Directory of Open Access Journals (Sweden)

    Milena D. Stojanovic

    2018-01-01

    Full Text Available The beginnings of the enhanced recovery after surgery (ERAS program were first developed for patients in colorectal surgery, and after it was established as the standard of care in this surgical field, it began to be applied in many others surgical areas. This is multimodal, evidence-based approach program and includes simultaneous optimization of preoperative status of patients, adequate selection of surgical procedure and postoperative management. The aim of this program is to reduce complications, the length of hospital stay and to improve the patients outcome. Over the past decades, special attention was directed to the postoperative management in vascular surgery, especially after major vascular surgery because of the great risk of multiorgan failure, such as: respiratory failure, myocardial infarction, hemodynamic instability, coagulopathy, renal failure, neurological disorders, and intra-abdominal complications. Although a lot of effort was put into it, there is no unique acceptable program for ERAS in this surgical field, and there is still a need to point out the factors responsible for postoperative outcomes of these patients. So far, it is known that special attention should be paid to already existing diseases, type and the duration of the surgical intervention, hemodynamic and fluid management, nutrition, pain management, and early mobilization of patients.

  17. Vascular access for home haemodialysis.

    Science.gov (United States)

    Al Shakarchi, Julien; Day, C; Inston, N

    2018-03-01

    Home haemodialysis has been advocated due to improved quality of life. However, there are very little data on the optimum vascular access for it. A retrospective cohort study was carried on all patients who initiated home haemodialysis between 2011 and 2016 at a large university hospital. Access-related hospital admissions and interventions were used as primary outcome measures. Our cohort consisted of 74 patients. On initiation of home haemodialysis, 62 individuals were using an arteriovenous fistula as vascular access, while the remaining were on a tunnelled dialysis catheter. Of the 12 patients who started on a tunnelled dialysis catheter, 5 were subsequently converted to either an arteriovenous fistula ( n = 4) or an arteriovenous graft ( n = 1). During the period of home haemodialysis use, four arteriovenous fistula failed or thrombosed with patients continuing on home haemodialysis using an arteriovenous graft ( n = 3) or a tunnelled dialysis catheter ( n = 1). To maintain uninterrupted home haemodialysis, interventional rates were 0.32 per arteriovenous fistula/arteriovenous graft access-year and 0.4 per tunnelled dialysis catheter access-year. Hospital admission rates for patients on home haemodialysis were 0.33 per patient-year. Our study has shown that home haemodialysis can be safely and independently performed at home within a closely managed home haemodialysis programme. The authors also advocate the use of arteriovenous fistulas for this cohort of patients due to both low complication and intervention rates.

  18. Vascular emergencies in liver trauma

    Energy Technology Data Exchange (ETDEWEB)

    Taourel, P. [Centre Hospitalier Universitaire Lapeyronie, Montpellier (France)], E-mail: p-taourel@chu-montpellier.fr; Vernhet, H. [Centre Hospitalier Universitaire Arnaud de Villeneuve, Montpellier (France); Suau, A.; Granier, C. [Centre Hospitalier Universitaire Lapeyronie, Montpellier (France); Lopez, F.M. [Centre Hospitalier Universitaire, Nimes (France); Aufort, S. [Centre Hospitalier Universitaire Lapeyronie, Montpellier (France)

    2007-10-15

    The use of CT in the diagnosis and management of liver trauma is responsible for the shift from routine surgical versus non-surgical treatment in the management of traumatic liver injuries, even when they are of high grade. The main cause of compli cation and of death in liver trauma is related to vascular injury. The goal of this review focussed on the vascular complications of liver trauma is to describe the elementary lesions shown by CT in liver trauma including laceration, parenchymal hematoma and contusions, partial devascularisation, subcapsular hematomas, hemoperitoneum, active bleeding, pseudoaneurysm of the hepatic artery, bile leak, and periportal oedema, to illustrate the possible pitfalls in CT diagnosis of liver trauma and to underline the key-points which may absolutely be present in a CT report of liver trauma. Then we will remind the grading system based on the CT features and we will analyze the interest and limitations of such grading systems. Last we will discuss the diagnostic strategy at the early phase in patients with suspected liver trauma according to their clinical conditions and underline the conditions of arterial embolization, and then we will discuss the diagnosis strategy at the delayed phase according to the suspected complications.

  19. Vascular emergencies in liver trauma

    International Nuclear Information System (INIS)

    Taourel, P.; Vernhet, H.; Suau, A.; Granier, C.; Lopez, F.M.; Aufort, S.

    2007-01-01

    The use of CT in the diagnosis and management of liver trauma is responsible for the shift from routine surgical versus non-surgical treatment in the management of traumatic liver injuries, even when they are of high grade. The main cause of compli cation and of death in liver trauma is related to vascular injury. The goal of this review focussed on the vascular complications of liver trauma is to describe the elementary lesions shown by CT in liver trauma including laceration, parenchymal hematoma and contusions, partial devascularisation, subcapsular hematomas, hemoperitoneum, active bleeding, pseudoaneurysm of the hepatic artery, bile leak, and periportal oedema, to illustrate the possible pitfalls in CT diagnosis of liver trauma and to underline the key-points which may absolutely be present in a CT report of liver trauma. Then we will remind the grading system based on the CT features and we will analyze the interest and limitations of such grading systems. Last we will discuss the diagnostic strategy at the early phase in patients with suspected liver trauma according to their clinical conditions and underline the conditions of arterial embolization, and then we will discuss the diagnosis strategy at the delayed phase according to the suspected complications

  20. Vascularized bone transplant chimerism mediated by vascular endothelial growth factor.

    Science.gov (United States)

    Willems, Wouter F; Larsen, Mikko; Friedrich, Patricia F; Bishop, Allen T

    2015-01-01

    Vascular endothelial growth factor (VEGF) induces angiogenesis and osteogenesis in bone allotransplants. We aim to determine whether bone remodeling in VEGF-treated bone allotransplants results from repopulation with circulation-derived autogenous cells or survival of allogenic transplant-derived cells. Vascularized femoral bone transplants were transplanted from female Dark Agouti rats (DA;RT1(a) ) to male Piebald Viral Glaxo (PVG;RT1(c) ). Arteriovenous bundle implantation and short-term immunosuppression were used to maintain cellular viability. VEGF was encapsulated in biodegradable microspheres and delivered intramedullary in the experimental group (n = 22). In the control group (n = 22), no VEGF was delivered. Rats were sacrificed at 4 or 18 weeks. Laser capture microdissection of bone remodeling areas was performed at the inner and outer cortex. Sex-mismatched genes were quantified with reverse transcription-polymerase chain reaction to determine the amount of male cells to total cells, defined as the relative expression ratio (rER). At 4 weeks, rER was significantly higher at the inner cortex in VEGF-treated transplants as compared to untreated transplants (0.622 ± 0.225 vs. 0.362 ± 0.081, P = 0.043). At 4 weeks, the outer cortex in the control group had a significantly higher rER (P = 0.038), whereas in the VEGF group, the inner cortex had a higher rER (P = 0.015). Over time, in the outer cortex the rER significantly increased to 0.634 ± 0.106 at 18 weeks in VEGF-treated rats (P = 0.049). At 18 weeks, the rER was >0.5 at all cortical areas in both groups. These in vivo findings suggest a chemotactic effect of intramedullary applied VEGF on recipient-derived bone and could imply that more rapid angiogenesis of vascularized allotransplants can be established with microencapsulated VEGF. © 2014 Wiley Periodicals, Inc.

  1. Proatherogenic pathways leading to vascular calcification

    International Nuclear Information System (INIS)

    Mazzini, Michael J.; Schulze, P. Christian

    2006-01-01

    Cardiovascular disease is the leading cause of morbidity and mortality in the western world and atherosclerosis is the major common underlying disease. The pathogenesis of atherosclerosis involves local vascular injury, inflammation and oxidative stress as well as vascular calcification. Vascular calcification has long been regarded as a degenerative process leading to mineral deposition in the vascular wall characteristic for late stages of atherosclerosis. However, recent studies identified vascular calcification in early stages of atherosclerosis and its occurrence has been linked to clinical events in patients with cardiovascular disease. Its degree correlates with local vascular inflammation and with the overall impact and the progression of atherosclerosis. Over the last decade, diverse and highly regulated molecular signaling cascades controlling vascular calcification have been described. Local and circulating molecules such as osteopontin, osteoprogerin, leptin and matrix Gla protein were identified as critical regulators of vascular calcification. We here review the current knowledge on molecular pathways of vascular calcification and their relevance for the progression of cardiovascular disease

  2. World Federation of Vascular Societies: presidential address

    DEFF Research Database (Denmark)

    Sillesen, Henrik Hegaard

    2010-01-01

    The presidential address describes briefly the history of the World Federation for Vascular Societies (WFVS) and its objectives. Vascular Surgery today includes interventional procedures (open surgical and endovascular) in addition to risk factor reduction and medical treatment. It is equally imp...... throughout the world. In addition, for introduction of new treatments, training issues and dissemination of science a global organisation like the WFVS is needed.......The presidential address describes briefly the history of the World Federation for Vascular Societies (WFVS) and its objectives. Vascular Surgery today includes interventional procedures (open surgical and endovascular) in addition to risk factor reduction and medical treatment. It is equally...

  3. Edema agudo do pulmão pós-extubação traqueal – Caso clínico

    Directory of Open Access Journals (Sweden)

    Maria de Lurdes Castro

    2009-05-01

    Full Text Available Resumo: O edema agudo do pulmão pós-extubação traqueal é um acontecimento raro (≈ 0,1%1. A etiologia é multifactorial, sendo a obstrução da via aérea superior o factor desencadeante principal. O esforço inspiratório contra a glote encerrada causa pressões intratorácicas muito negativas, que se transmitem ao interstício pul-monar, condicionando uma transudação de fluidos a partir dos vasos capilares pulmonares1−5. Relatamos um caso de edema agudo do pulmão pós-extubação num doente de quinze anos, operado no serviço de urgência por amputação traumática da perna esquer-da. Revemos a fisiopatologia, o padrão radiológico, potenciais factores de risco e medidas preventivas des-ta complicação respiratória pós-anestésica.Rev Port Pneumol 2009; XV (3: 537-541 Abstract: Negative pressure pulmonary oedema is an uncommon complication of traqueal extubation (≈ 0,1% mostly caused by acute upper airway obstruction. Upper airway obstruction from glottis closure leads to marked inspiratory effort, which generates negative intrathoracic pressure transmitting to pulmonary interstitium, and inducing fluid transudation from pulmonary capillary bed1−5. We report a case of post-extubation pulmonary oedema in a fifteen years old patient, submitted to surgery following traumatic amputation of his left leg. We review the pathophysiology, radiological findings, potential risk factors and preventive measures of this post-anaesthetic respiratory complication.Rev Port Pneumol 2009; XV (3: 537-541 Palavras-chave: Edema agudo do pulmão pós-extubação traqueal, obstrução da via aérea superior, laringospasmo, pressão negativa intratorácica, Key-words: Post-extubation pulmonary oedema, upper airway obstruction, laryngospasm, intra-thoracic negative pressure

  4. Mobilization and early hospital discharge for patients with acute myocardial infarction: literature review Movilización y alta precoz en pacientes con infarto agudo del miocardio: revisión de lieratura Mobilização e alta precoce em pacientes com infarto agudo do miocárdio: revisão de literatura

    Directory of Open Access Journals (Sweden)

    Juliana de Lima Lopes

    2008-01-01

    Full Text Available OBJECTIVE: This study was a literature review with the purpose of analyzing articles comparing early and late mobilization and those comparing early and late discharge for patients with acute myocardial infarction. METHODS: The literature review was performed using the Lilacs and Medline databases (1966-2007, and the length of the resting period, the hospitalization and possible complications were analyzed. RESULTS: We selected 18 articles; 11 of them compared early and late mobilization and 7 compared early and late discharge. The length of the resting period in the early mobilization group varied from 2 to 10 days and 5 to 28 days for the longest resting period. The early discharge group stayed in the hospital from 3 to 14 days and the late discharge group stayed in the hospital from 5 to 21 days. CONCLUSION: The studies show that there is no evidence of complications related to short periods of bed rest and hospitalization.OBJETIVO: Analizar los artículos que comparaban la movilización precoz con la tardía, así como aquellos que comparaban el alta precoz con la tardía en pacientes con infarto agudo del miocardio. MÉTODOS: La revisión bibliográfica fue realizada en las Bases de Datos Lilacs y Medline, y fueron analizados el tiempo de reposo y de hospitalización y las complicaciones observadas en los estudios. RESULTADOS: Fueron seleccionados 18 artículos, difundidos entre 1996 y 2007, de los cuales 11 comparaban la movilización precoz con la tardía y 7 el alta precoz con la tardía. El período de reposo en la cama para la movilización precoz varió de 2 a 10 días y de 5 a 28 días para la movilización tardía. Con relación al tiempo de hospitalización se observó que el período de alta precoz varió de 3 a 14 días y de 5 a 21 días para el alta tardía. CONCLUSIÓN: Los estudios muestran que no hay evidencias de mayores complicaciones relacionadas a los cortos períodos de reposo y de hospitalización.OBJETIVO: Analisar os

  5. Os significados da palavra conforto segundo a perspectiva do paciente com infarto agudo do miocárdio Los significados de la palabra bienestar según la perspectiva del paciente con infarto agudo del miocardio The meaning of the word comfort from the point of view of patients with acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Fernanda Carneiro Mussi

    1996-12-01

    Full Text Available O estudo objetivou identificar o significado da palavra conforto conferido por pacientes com infarto agudo do miocárdio, do sexo masculino, internados numa Unidade Coronariana do município de São Paulo. A coleta de dados foi realizada por meio de formulário específico. As respostas às questões abertas foram tratadas utilizando-se o método de análise de conteúdo de BARDIN², e os resultados basicamente analisados sob a forma de números absolutos percentuais. O conforto enquanto significado foi expressado com vários sentidos, relacionando-se com as condições materiais ou financeiras (29,4%, o desfrutar das interações pessoais (21,6%, as sensações de bem-estar psicológico (13,7%, físico (11,8% e espiritual (9,8%, o funcionar normalmente (13,7%, isto é, Ter expectativas de recuperação, estar livre de doenças e poder desempenhar as atividades habituais.El objetivo del estudio fue identificar cuál es el significado que los pacientes de sexo masculino diagnosticado con infarto agudo del miocardio, internados en una unidad coronaria del municipio de São Paulo, le dan a la palabra bienestar. La fuente de los datos fue obtenida por medio de un formulario específico. Las respuestas a las preguntas abiertas fueron tratadas utilizándose en método de análisis de contenido de BARDIN² y los resultados básicamente analizados sobre la forma de números absolutos y porcentuales. En cuanto el significado de bienestar fue expresado con varios sentidos, relacionándose con las condiciones materiales o financieras (29,4%, el disfrute de las interacciones personales (21,6% las sensaciones del bienestar psicológico (13,7%, físico (11,8% y espiritual (9,8%, el funcionar normalmente (13,7% esto es, tener expectativa de recuperación, estar libre de enfermedad y poder desempeñar las actividades habituales. Además de las conclusiones relacionadas directamente a los objetivos, los resultados del presente estudio permiten decir también: a

  6. Perda da espontaneidade da ação: o desconforto de homens que sofreram infarto agudo do miocardio Perdida de la expontaneidad de la accion: el desconforto de hombres que sufrieron infarto agudo del miocardio Undergoing loss of spontaneous action: the discomfort experienced by men having suffered acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Fernanda Carneiro Mussi

    2002-06-01

    Full Text Available Considerando que conforto - cuja promoção é uma das metas centrais da enfermagem -- e desconforto devem ser entendidos àluz das interações vivenciadas pelo paciente - e, portanto, vinculadas aos fatores objetivos das instituições, da nacionalidade epráticas que as fundamentam - este estudo investigou os significados de conforto e desconforto na perspectiva de homens quesofreram infarto agudo do miocárdio (IAM. Recorrendo ao Interacionismo Simbólico eàmetodologia da Teoria Fundamentadanos Dados, entrevistas foram feitas com 13 homens que sofreram IAM, em duas unidades de saúde na cidade de São Paulo. Aanálise permitiu construir um modelo teórico daqueles significados nessa experiência, caracterizada por três fenômenos eessencialmente permeada pelo desconforto de "padecer a perda da espontaneidade daação ".Este artigo resume o processopsicossocial básico da experiência, discutindo suas implicações para questionar o modelo clínico de intervenção, apontando apossibilidade de a enfermagem atuar na prevenção e propondo questões para aprimorar a formação do enfermeiro.Considerando que conforto - cuya promoción es una de las metas centralés de la enfermeria - y desconforto deven ser entendidos a la luz de las interacciones vivenciadas por el paciente e por lo tanto, vinculadas a los factores objetivos de las instituciones, dela racionalidad y de las prácticas que las fundamentan - este estudio investigo los significados de conforto e desconforto en la prespectiva de hombres que sufrieron infarto agudo del miocardio (IAM. Acudiendo al Interaccionismo SimbólicoYala meto-dologia de la Teoria Fudamentada en los datos, fueron realizadas entrevistas com 13 hombres que sufrieron IAM en dos unida-des de salud en la cuidad de São Paulo. El análisis permitio construir um modelo teórico de aquellos significados en esa experi-encia, caracterizada por tres fenómenos y esencialmente condicionada por el desconforto de "padecer

  7. [Immunologic problems in vascular homografts].

    Science.gov (United States)

    D'Addato, M; Mirelli, M

    2001-01-01

    Fresh arterial homografts are immunogenic, inducing in recipient a strong immune response specifically directed against the antigens of the donor graft. The initial immune response seems to be cellular (lymphocytotoxic) and the late reaction humoral (antibody), even if they are strictly correlated. Immunosuppressive therapy reduce the immune reaction, but this response is dose-related. Implanted arterial homografts induce a donor-specific response similar to chronic reaction, which occurs in the recipients of vascularized solid-organ allografts. Therefore, in arterial transplantation, ABO compatibility and negative crossmatch should be respected. Effort should be made to curb the immune response by prospective cross-matching, immunosuppressive therapy and preoperative manipulation of homografts to reduce their antigenicity.

  8. Heritability of Retinal Vascular Fractals

    DEFF Research Database (Denmark)

    Vergmann, Anna Stage; Broe, Rebecca; Kessel, Line

    2017-01-01

    Purpose: To determine the genetic contribution to the pattern of retinal vascular branching expressed by its fractal dimension. Methods: This was a cross-sectional study of 50 monozygotic and 49 dizygotic, same-sex twin pairs aged 20 to 46 years. In 50°, disc-centered fundus photographs, the reti...... fractal dimension did not differ statistically significantly between monozygotic and dizygotic twin pairs (1.505 vs. 1.495, P = 0.06), supporting that the study population was suitable for quantitative analysis of heritability. The intrapair correlation was markedly higher (0.505, P = 0.......0002) in monozygotic twins than in dizygotic twins (0.108, P = 0.46), corresponding to a heritability h2 for the fractal dimension of 0.79. In quantitative genetic models, dominant genetic effects explained 54% of the variation and 46% was individually environmentally determined. Conclusions: In young adult twins...

  9. Vascular anastomosis by Argon Laser

    International Nuclear Information System (INIS)

    Gomes, O.M.; Macruz, R.; Armelin, E.; Brum, J.M.G.; Ribeiro, M.P.; Mnitentog, J.; Verginelli, G.; Pileggi, F.; Zerbini, E.J.

    1982-01-01

    Twenty four mongrel dogs, wheighing 13 to 24 kilograms were studied. After anesthesia, intubation and controlled ventilation, they were submitted to three types of vascular anastomosis: Group I - eight dogs with saphenous vein inter-carotid arteries by-pass: Group II - eight dogs with left mammary artery - left anterior descending coronary artery by-pass; Group III - eight dogs with venovenous anastomosis. In all groups 0.8 to 15 watts of Argon Laser power was applied to a total time of 90 to 300 seconds. The lower power for venovenous anastomosis and the greater for the arterial ones. The mean valves of resistence of the Laser anastomosis to pressure induced rupture was 730 mmHg in the immediate post operative study, and superior to 2.500 mmHg 30 days after. No signs of occlusion was demonstrated at the anastomosis sites by the angiographic and anathomo-patological study performed. (Author) [pt

  10. Vascular targeting with peptide libraries

    Energy Technology Data Exchange (ETDEWEB)

    Pasqualini, R. [La Jolla Cancer Research Center The Burnham Inst., La Jolla CA (United States)

    1999-06-01

    The authors have developed an 'in vivo' selection system in which phage capable of selective homing to different tissues are recovered from a phage display peptide library following intravenous administration. Using this strategy, they have isolate several organ and tumor-homing peptides. They have shown that each of those peptides binds of different receptors that are selectively expressed on the vasculature of the target tissue. The tumor-homing peptides bind to receptors that are up regulated in tumor angiogenic vasculature. Targeted delivery of doxorubicin to angiogenic vasculature using these peptides in animals models decrease toxicity and increased the therapeutic efficacy of the drug. Vascular targeting may facilitate the development of other treatment strategies that rely on inhibition of angio genesis and lead to advances to extend the potential for targeting of drugs, genes and radionuclides in the context of many diseases.

  11. Vascular Morphodynamics During Secondary Growth.

    Science.gov (United States)

    de Reuille, Pierre Barbier; Ragni, Laura

    2017-01-01

    Quantification of vascular morphodynamics during secondary growth has been hampered by the scale of the process. Even in the tiny model plant Arabidopsis thaliana, the xylem can include more than 2000 cells in a single cross section, rendering manual counting impractical. Moreover, due to its deep location, xylem is an inaccessible tissue, limiting live imaging. A novel method to visualize and measure secondary growth progression has been proposed: "the Quantitative Histology" approach. This method is based on a detailed anatomical atlas, and image segmentation coupled with machine learning to automatically extract cell shapes and identify cell type. Here we present a new version of this approach, with a user-friendly interface implemented in the open source software LithoGraphX.

  12. Adiposity, adipocytokines & microvesicles in the etiology of vascular disease

    NARCIS (Netherlands)

    Kanhai, D.A.N.I.S.

    2013-01-01

    Vascular disease, in this thesis the terms vascular and cardiovascular are used interchangeably, is the number 1 cause of death worldwide. In 2008, 30% of all mortality had a vascular origin. Vascular mortality rates after a first manifestation of vascular disease are decreasing in Western society,

  13. FPGA controlled artificial vascular system

    Directory of Open Access Journals (Sweden)

    Laqua D.

    2015-09-01

    Full Text Available Monitoring the oxygen saturation of an unborn child is an invasive procedure, so far. Transabdominal fetal pulse oximetry is a promising method under research, used to estimate the oxygen saturation of a fetus noninvasively. Due to the nature of the method, the fetal information needs to be extracted from a mixed signal. To properly evaluate signal processing algorithms, a phantom modeling fetal and maternal blood circuits and tissue layers is necessary. This paper presents an improved hardware concept for an artificial vascular system, utilizing an FPGA based CompactRIO System from National Instruments. The experimental model to simulate the maternal and fetal blood pressure curve consists of two identical hydraulic circuits. Each of these circuits consists of a pre-pressure system and an artificial vascular system. Pulse curves are generated by proportional valves, separating these two systems. The dilation of the fetal and maternal artificial vessels in tissue substitutes is measured by transmissive and reflective photoplethysmography. The measurement results from the pressure sensors and the transmissive optical sensors are visualized to show the functionality of the pulse generating systems. The trigger frequency for the maternal valve was set to 1 per second, the fetal valve was actuated at 0.7 per second for validation. The reflective curve, capturing pulsations of the fetal and maternal circuit, was obtained with a high power LED (905 nm as light source. The results show that the system generates pulse curves, similar to its physiological equivalent. Further, the acquired reflective optical signal is modulated by the alternating diameter of the tubes of both circuits, allowing for tests of signal processing algorithms.

  14. Dynamics of nephron-vascular network

    DEFF Research Database (Denmark)

    Postnov, Dmitry; Postnov, D E; Marsh, D J

    2012-01-01

    The paper presents a modeling study of the spatial dynamics of a nephro-vascular network consisting of individual nephrons connected via a tree-like vascular branching structure. We focus on the effects of nonlinear mechanisms that are responsible for the formation of synchronous patterns in order...

  15. Imaging of the peripheral vascular system

    International Nuclear Information System (INIS)

    Gould, S.A.; Pond, G.D.; Pinsky, S.; Moss, G.S.; Srikantaswamy, S.; Ryo, U.Y.

    1984-01-01

    This book is limited neither to the peripheral vascular system nor to diagnostic imaging techniques. Its 18 chapters cover nonimaging blood-flow techniques (Doppler ultrasound, plethysmography) as well as noninvasive and invasive imaging techniques (ultrasound, computed tomography, radionuclide digital-subtraction angiography, and contrast angiography). These are applied not only to the peripheral vascular system but also to the aorta and vena cava

  16. Biomarkers of drug-induced vascular injury

    International Nuclear Information System (INIS)

    Brott, D.; Gould, S.; Jones, H.; Schofield, J.; Prior, H.; Valentin, J.P; Bjurstrom, S.; Kenne, K.; Schuppe-Koistinen, I.; Katein, A.; Foster-Brown, L.; Betton, G.; Richardson, R.; Evans, G.; Louden, C.

    2005-01-01

    In pre-clinical safety studies, drug-induced vascular injury is an issue of concern because there are no obvious diagnostic markers for pre-clinical or clinical monitoring and there is an intellectual gap in our understanding of the pathogenesis of this lesion. While vasodilatation and increased shear stress appear to play a role, the exact mechanism(s) of injury to the primary targets, smooth muscle and endothelial cells are unknown. However, evaluation of novel markers for potential clinical monitoring with a mechanistic underpinning would add value in risk assessment and management. This mini review focuses on the progress to identify diagnostic markers of drug-induced vascular injury. Von Willebrand factor (vWF), released upon perturbation of endothelial cells, is transiently increased in plasma prior to morphological evidence of damage in dogs or rats treated with vascular toxicants. Therefore, vWF might be a predictive biomarker of vascular injury. However, vWF is not an appropriate biomarker of lesion progression or severity since levels return to baseline values when there is morphological evidence of injury. A potential mechanistically linked biomarker of vascular injury is caveolin-1. Expression of this protein, localized primarily to smooth muscle and endothelial cells, decreases with the onset of vascular damage. Since vascular injury involves multiple mediators and cell types, evaluation of a panel rather than a single biomarker may be more useful in monitoring early and severe progressive vascular injury

  17. Reconstructive vascular surgery below the knee

    DEFF Research Database (Denmark)

    Rasmussen, L B; Jelnes, R; Sager, P

    1986-01-01

    In a series of 38 consecutive patients with advanced peripheral vascular disease (i.e. rest pain) reconstructive vascular surgery was performed with the distal anastomosis below the knee. Ankle/arm pressure index (AAI) was 0.28 (0.11-0.47) preoperatively; accumulated graft patency rate was 0.47 (SD...

  18. Vascular dementia | Connor | African Journal of Psychiatry

    African Journals Online (AJOL)

    Vascular dementia (VaD) is a common but heterogeneous condition in which there is a clear temporal relationship between the dementia and vascular disease. It may result from multiple large or small vessel strokes or a single strategic stroke. Subcortical ischaemic VaD includes multiple lacunes and subcortical ...

  19. PanVascular medicine. 2. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Lanzer, Peter (ed.) [Health Care Center Bitterfeld (Germany). Division of Cardiovascular Disease

    2015-06-01

    Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.

  20. Using Polymeric Scaffolds for Vascular Tissue Engineering

    Directory of Open Access Journals (Sweden)

    Alida Abruzzo

    2014-01-01

    Full Text Available With the high occurrence of cardiovascular disease and increasing numbers of patients requiring vascular access, there is a significant need for small-diameter (<6 mm inner diameter vascular graft that can provide long-term patency. Despite the technological improvements, restenosis and graft thrombosis continue to hamper the success of the implants. Vascular tissue engineering is a new field that has undergone enormous growth over the last decade and has proposed valid solutions for blood vessels repair. The goal of vascular tissue engineering is to produce neovessels and neoorgan tissue from autologous cells using a biodegradable polymer as a scaffold. The most important advantage of tissue-engineered implants is that these tissues can grow, remodel, rebuild, and respond to injury. This review describes the development of polymeric materials over the years and current tissue engineering strategies for the improvement of vascular conduits.

  1. Postoperative radiographic evaluation of vascularized fibular grafts

    International Nuclear Information System (INIS)

    Manaster, B.J.; Coleman, D.A.; Bell, D.A.

    1989-01-01

    This paper reports on thirty-five patients with free vascularized fibular grafts examined postoperatively with plain radiography. Early graft incorporation is seen as a fuzziness of the cortex at the site of its insertion into the host bone. Causes of failure in grafting for bone defects include graft fracture, hardware failure, and infection. A high percentage of complications or at least delayed unions occurred when vascularized fibular grafts were used to fill defects in the lower extremity. Conversely, upper extremity defects bridged by vascularized grafts heal quickly and hypertrophy. Vascularized grafts placed in the femoral head and neck for a vascular necrosis incorporate early on their superior aspect. The osseous tunnel in which they are placed is normally wider than the graft and often becomes sclerotic; this appearance does not represent nonunion

  2. PanVascular medicine. 2. ed.

    International Nuclear Information System (INIS)

    Lanzer, Peter

    2015-01-01

    Vascular management and care has become a truly multidisciplinary enterprise as the number of specialists involved in the treatment of patients with vascular diseases has steadily increased. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. Pan Vascular Medicine, 2nd edition has been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.

  3. O manejo da síndrome do desconforto respiratório agudo Management of the acute respiratory distress syndrome

    Directory of Open Access Journals (Sweden)

    Alexandre Tellechea Rotta

    2003-11-01

    Full Text Available OBJETIVO: Revisar as atuais estratégias de suporte e de tratamento da síndrome do desconforto respiratório agudo (SDRA. FONTE DOS DADOS: Dados próprios de nosso laboratório de pesquisa e bibliografia relacionada às áreas de SDRA e lesão pulmonar aguda, pesquisados através do Medline. SÍNTESE DOS DADOS: Apesar de avanços no entendimento da sua patogênese, a SDRA ainda resulta em significativa morbidade e mortalidade. A ventilação mecânica é a principal modalidade terapêutica na SDRA, sendo atualmente considerada não mais apenas uma medida de suporte, mas sim uma terapia capaz de alterar o curso da patologia. Novas estratégias ventilatórias, como a ventilação oscilatória de alta freqüência (VOAF, têm-se mostrado promissoras. Neste texto, revisamos o conhecimento atual no manejo da SDRA, incluindo ventilação mecânica convencional e não convencional, uso de surfactante, óxido nítrico, moduladores do processo inflamatório, oxigenação extracorpórea e posição prona. CONCLUSÕES: A última década foi marcada por avanços significativos, como o conceito de ventilação mecânica protetora na SDRA. O benefício da aplicação de estratégias alternativas, como a VOAF, assim como do uso do surfactante exógeno e moduladores de inflamação continuam sendo alvo de estudo.OBJECTIVE: To review the current support and treatment strategies of the Acute Respiratory Distress Syndrome (ARDS DATA SOURCES: Original data from our research laboratory and from representative scientific articles on ARDS and acute lung Injury searched through Medline. SUMMARY OF THE FINDINGS: Despite advances in the understanding of the pathogenesis of ARDS, this syndrome still results in significant morbidity and mortality. Mechanical ventilation, the main therapeutic modality for ARDS, is no longer considered simply a support modality, but a therapy capable of influencing the course of the disease. New ventilation strategies, such as high

  4. Síndrome do desconforto respiratório agudo pulmonar e extrapulmonar: existem diferenças? Pulmonary and extrapulmonary acute respiratory distress syndrome: are they different?

    Directory of Open Access Journals (Sweden)

    Cristiane S. N. Baez Garcia

    2008-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A patogênese da síndrome do desconforto respiratório agudo (SDRA tem sido explicada pela presença de uma agressão direta (SDRA pulmonar e/ou indireta (SDRA extrapulmonar ao parênquima pulmonar. Evidências indicam que a fisiopatologia da doença pode diferir com o tipo de lesão. O objetivo deste estudo foi apresentar breve revisão das diferenças entre a SDRA pulmonar e a SDRA extrapulmonar e discutir as interações entre os aspectos morfofuncionais e a resposta aos diferentes tratamentos. CONTEÚDO: Esta revisão bibliográfica baseou-se em uma pesquisa sistemática de artigos experimentais e clínicos sobre SDRA incluídos nas bases de dados MedLine e SciElo nos últimos 20 anos. Muitos pesquisadores concordam, com base em estudos experimentais, que a SDRA pulmonar e a SDRA extrapulmonar não são idênticas no que diz respeito aos aspectos morfofuncionais, a resposta à pressão positiva ao final da expiração (PEEP, manobra de recrutamento alveolar, posição prona e outras terapias farmacológicas. Entretanto, os estudos clínicos têm descrito resultados contraditórios, os quais podem ser atribuídos à dificuldade de se classificar a SDRA em uma ou outra etiologia, e de se precisar o início, a fase e a gravidade da SDRA nos pacientes. CONCLUSÕES: Pacientes com SDRA de etiologias distintas perduram sendo considerados como pertencendo a uma mesma síndrome e, assim, são tratados da mesma forma. Logo, é fundamental entender as diferenças fisiopatológicas entre a SDRA pulmonar e extrapulmonar para que a terapia seja mais bem direcionada.BACKGROUND AND OBJECTIVES: The pathogenesis of acute respiratory distress syndrome (ARDS has been described by the presence of direct (pulmonary and/or indirect (extrapulmonary insult to the lung parenchyma. Evidence indicates that the pathophysiology of ARDS may differ according to the type of primary insult. This article presents a brief overview of differences

  5. Comportamiento del fallo renal agudo en niños con sepsis grave Behavior of acute renal failure in children presenting with severe sepsis

    Directory of Open Access Journals (Sweden)

    María del Carmen Saura Hernández

    2010-03-01

    Full Text Available INTRODUCCIÓN. El objetivo de esta investigación fue determinar los factores de riesgo asociados al fallo renal agudo (FRA en un grupo de niños con sepsis grave atendidos entre enero del 2004 y diciembre del 2008. MÉTODOS. Se realizó un estudio observacional y analítico con una muestra de 171 pacientes. Se constituyeron dos grupos: el de estudio, integrado por 38 pacientes con estado de choque séptico o disfunción múltiple de órganos (DMO y FRA, y un grupo control, conformado por 133 niños en igual estadio de sepsis pero con función renal normal. Se revisaron las historias clínicas y se tuvieron en cuenta variables epidemiológicas, factores de riesgo de FRA y evolución de los casos. RESULTADOS. La incidencia de FRA fue del 22,2 %, y aunque disminuyó considerablemente en los 3 últimos años del estudio, la mortalidad fue del 42,1 %, mayoritariamente en el DMO (89,5 %. Se encontró dependencia entre la insuficiencia renal y la respuesta diurética no adecuada a la fluidoterapia (51,2 %, la inestabilidad hemodinámica por más de 24 h (46,5 %, la disfunción miocárdica (43,3 % y el uso de medicamentos nefrotóxicos (42,8 %. CONCLUSIONES. La respuesta diurética no adecuada a la fluidoterapia, la inestabilidad hemodinámica por más de 24 h, la disfunción miocárdica y el uso de medicamentos nefrotóxicos incrementan el riesgo de FRA en la sepsis grave, la cual duplica la mortalidad en relación con los pacientes que conservan la función renal. No obstante, la prevención de las formas graves de sepsis y un tratamiento adecuado de ésta disminuyen la incidencia de FRA.INTRODUCTION: The aim of present research was to determine the risk factor associated with the acute renal failure (ARF in a group of children with severe sepsis seen between January, 2004 and December, 2008. METHODS: An analytical and observational study was conducted in a sample including 171 patients. There were two groups: the study-group with 138 patients with

  6. Ejercicio y la detección del mal agudo de montaña grave Exercise and the detection of severe acute mountain sickness

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    Adrián Garófoli

    2010-02-01

    Full Text Available El mal agudo de montaña (MAM es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2.700 m y 4 300 m en 63 sujetos que ascendían al cerro Aconcagua (6 962 m. Se consideró desaturación de oxígeno con ejercicio a una disminución = 5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. Seis sujetos presentaron MAM grave (9.5% y requirieron evacuación. La saturación de oxígeno en reposo a 2.700 m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2.700 m más la saturación inapropiada en reposo a 4.300 m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave.Acute mountain sickness (AMS is a group of non-specific symptoms, seen in subjects that ascend from low to high altitude too quickly, without allowing sufficient time to acclimatize. Usually it is self-limiting, but the severe forms (pulmonary and cerebral edema can be fatal. Exaggerated hypoxemia at rest is related to later development of AMS but its predictive value is limited. Since exercise at altitude induces greater hypoxemia and

  7. Nefropatía por contraste en el síndrome coronario agudo Contrast induced nephropathy in acute coronary syndrome

    Directory of Open Access Journals (Sweden)

    Mariana Carnevalini

    2011-10-01

    Full Text Available La nefropatía inducida por contraste (NIC es una de las causas más frecuentes de insuficiencia renal en pacientes internados. En el síndrome coronario agudo (SCA, la presencia de NIC aumenta la morbimortalidad. Las medidas de profilaxis y los factores de riesgo intervinientes de NIC en SCA no han sido determinados con exactitud. El objetivo de este estudio fue evaluar la incidencia de NIC y los factores asociados a su desarrollo en pacientes ingresados en unidad coronaria con requerimiento de cinecoronariografía (CCG. Se realizó un estudio de cohorte retrospectivo. Se incluyeron pacientes consecutivos cursando SCA estudiados con CCG dentro de las 72 horas de su admisión. Se definió NIC al aumento del 25% del valor de creatinina a las 48 h sobre el nivel basal de ingreso. El período de inclusión fue entre el 1° de enero de 2004 hasta el 30 de junio de 2010. Se analizaron 125 casos. La incidencia de NIC fue del 10.4% (n = 13. En el análisis multivariado, los factores asociados independientemente a su desarrollo fueron la edad [OR 1.05 (IC 95% 1.004 - 1.11 p = 0.034], la angioplastia a múltiple vaso [OR 2.2 (IC 95% 1.07 - 4.8, p = 0.03] y el volumen de contraste utilizado [OR 1.007 (IC 95% 1.001 - 1.01, p = 0.014].Contrast induced nephropathy (CIN is one of the most frequent causes of acute renal failure in hospitalized patients. It is associated with an increase in morbidity and mortality in patients hospitalized for acute coronary syndrome (ACS undergoing percutaneous coronary intervention (PCI. Risk factors and prevention strategies are not well defined. The aim of this study was to assess the incidence and clinical risk factors associated to the development of contrast induced nephropathy in patients hospitalized for ACS. In a retrospective cohort we analyzed consecutive patients hospitalized for ACS undergoing urgent PCI within 72 hours from the admission. CIN was defined as a 25% increase of creatinine levels from baseline at 48

  8. Caracterización de la calidad de sedimentos afectados por vertidos de petróleo: comparación entre casos de vertidos accidentales (impacto agudo) frente a derrames continuos (impacto crónico)

    OpenAIRE

    Morales Caselles, Carmen

    2007-01-01

    La tesis presenta un estudio integral para carácterizar la calidad de sedimentos de dos áreas dél litoral españól afectadas por vertidos¿ de hidrocarburos. A finales del 2002 el accidente del petrolero monocasco Prestige provocó un vertido de 63000 toneladas de fuel oil pesado que se esparció en manchas, más o menos compactas y que supuso un impacto agudo de contaminación provocando una de las "mareas negras' más dañinas de las ocurridas en Galicia en los, últimos años Por-otra parte, la Babi...

  9. Efecto agudo del entrenamiento muscular excéntrico sobre la estabilidad del miembro inferior durante el aterrizaje después de caida desde diferentes alturas en jóvenes futbolistas de élite

    OpenAIRE

    Mateo Cortés, Jesús

    2013-01-01

    El objetivo principal de la presente investigación fue analizar el efecto agudo de una sesión de entrenamiento de fuerza con sobrecarga excéntrica sobre la estabilidad del miembro inferior tras aterrizaje después de caída desde altura de 30 cm y 50 cm. La muestra estuvo constituida por un total de dieciocho jugadores de fútbol (edad = 17 ± 1.2 años; altura = 178 ± 2,34 cm; peso = 71 ± 4.56 kg; IMC = 19.12 ± 2.45) pertenecientes a la cantera de un equipo profesional de fútbol de la liga españo...

  10. Síndrome do desconforto respiratório agudo relacionada à sepse em crianças com câncer: dinâmica respiratória de uma condição devastadora

    Directory of Open Access Journals (Sweden)

    Rodrigo Genaro Arduini

    Full Text Available RESUMO Objetivo: Avaliar a evolução clínica e os parâmetros respiratórios de crianças com câncer submetidas à ventilação mecânica que apresentavam síndrome do desconforto respiratório agudo relacionada à sepse. Métodos: Este estudo longitudinal, prospectivo e observacional de coorte com duração de 2 anos incluiu 29 crianças e adolescentes. Dados clínicos, avaliações de gasometria sanguínea e parâmetros ventilatórios foram coletados em quatro momentos diferentes. As flutuações entre as avaliações e as diferenças entre as médias estimadas foram analisadas por meio de modelos lineares mistos, tendo como parâmetro primário (endpoint a ocorrência de óbito dentro de 28 dias após o início da síndrome do desconforto respiratório agudo. Resultados: Ocorreram 17 óbitos dentro de 28 dias após o início da síndrome do desconforto respiratório agudo, e outros 7 entre 29 e 60 dias. Apenas cinco pacientes sobreviveram por mais de 60 dias. Nove (31% pacientes faleceram como consequência direta de hipoxemia refratária, e os demais em razão de falência de múltiplos órgãos e choque refratário a catecolaminas. Em 66% das avaliações, o volume corrente demandado para obter saturação de oxigênio igual ou acima de 90% foi superior a 7mL/kg. As médias estimadas de complacência dinâmica foram baixas e similares para sobreviventes e não sobreviventes, porém com inclinação negativa da reta entre a primeira e última avaliações, acompanhada por uma inclinação negativa da reta para volume corrente nos não sobreviventes. Os não sobreviventes tiveram significantemente mais hipoxemia, com relações PaO2/FiO2 que demonstravam médias mais baixas e inclinação negativa da reta nas quatro avaliações. As pressões pico, expiratória e média das vias aéreas demonstraram inclinações positivas na reta para os não sobreviventes, que também apresentaram mais acidose metabólica. Conclusões: Na maioria de

  11. Método de las invariantes en la conducta a seguir ante un paciente con abdomen agudo quirúrgico en el nivel primario de atención

    Directory of Open Access Journals (Sweden)

    Esteban Regalado García

    2003-08-01

    Full Text Available El médico que hoy formamos tiene una visión más integral de los problemas de salud del ser humano. En nuestro sistema de salud, el nivel primario constituye, en gran medida, su puerta de entrada. Los profesionales que laboran en este nivel deben estar preparados para resolver los problemas de salud propios de su especialidad e identificar aquellas entidades que deben ser resueltas en los otros niveles del sistema. El abdomen agudo quirúrgico es de los problemas de salud que deben ser atendidos oportunamente para evitar complicaciones, incluso fatales, en nuestros pacientes. Un método pedagógico para aprender los conocimientos necesarios, con calidad y que orienta la conducta correcta ante cada paciente, es el método de las invariantes. El concepto de invariante contempla la identificación de aquellas cuestiones fundamentales, esenciales y necesarias para poder sospechar un diagnóstico. Cuando el Médico General Integral conoce las invariantes de una entidad, puede tomar decisiones con un elevado margen de seguridad. Un abdomen agudo quirúrgico puede ser producido por cientos de enfermedades y estudiarlas una por una sería interminable; dada su gravedad, cualquier error que se cometa en su manejo puede ser fatal. Hemos identificado 7 signos invariantes en el abdomen agudo quirúrgico, estos signos que presentamos en este trabajo, pueden ser reconocidos en 9 de cada 10 pacientes que consultan con un dolor abdominal agudo. Existen dificultades para su identificación en un pequeño número de pacientes, a lo que hemos llamado "Situaciones Especiales".The physicians that we are preparing today have more comprehensive vision of the health problems of the human being. In our health care system, the primary health care level constitutes, in a greater extent, an entry door. Health professionals working at this level should be ready to solve health problems inherent to their specialty and to identify those entities that should be resolved at

  12. Efecto de un tratamiento agudo con norgestomet en la dinámica folicular de vacas Cebú x Holstein sincronizadas con implantes de norgestomet y eCG

    Directory of Open Access Journals (Sweden)

    R. Páez

    2005-01-01

    Full Text Available El objetivo del presente estudio fue evaluar el efecto de una inyección de norgestomet en la dinámica folicular de vacas Cebú x Holstein sincronizadas con implantes de norgestomet. Se utilizaron 50 vacas en lactación con más de 60 días posparto, las cuales recibieron un implante de 3 mg de norgestomet y una dosis luteolítica de PGF2a (día cero. El día cinco, a 25 vacas (grupo Norg, se les administraron 1.8 mg de norgestomet intramuscular (IM y 25 vacas (grupo testigo, recibieron 3 ml de solución salina. El noveno día se retiró el implante, se realizó un destete temporal por 72 h y los animales fueron divididos al azar dentro de sus tratamientos para recibir (n = 23 o no (n = 27 500 UI de eCG. Posteriormente, las vacas fueron observadas durante cinco días en forma continua para la detección de signos de estro. Se realizaron diariamente ecografías de los ovarios desde el día de la inserción del implante hasta la presentación de estro. El tratamiento agudo con norgestomet provocó recambio del folículo dominante (FD en 40% (10/25 de las vacas, contra 16% (4/25 del grupo testigo (P 0.05 el porcentaje de vacas que presentaron estro ni el tiempo de presentación del mismo. Se concluye que el tratamiento agudo con norgestomet, durante la sincronización del estro con progestágenos, provoca atresia y recambio folicular. Sin embargo, este efecto depende de la etapa de desarrollo del folículo dominante al momento del tratamiento.

  13. Edema agudo do pulmão pós-extubação traqueal - Caso clínico Post-tracheal extubation pulmonary oedema - Case report

    Directory of Open Access Journals (Sweden)

    Maria de Lurdes Castro

    2009-05-01

    Full Text Available O edema agudo do pulmão pós-extubação traqueal é um acontecimento raro (≈ 0,1%¹. A etiologia e multifactorial, sendo a obstrução da via aérea superior o factor desencadeante principal. O esforço inspiratório contra a glote encerrada causa pressões intratorácicas muito negativas, que se transmitem ao interstício pulmonar, condicionando uma transudação de fluidos a partir dos vasos capilares pulmonares1-5. Relatamos um caso de edema agudo do pulmão pós-extubação num doente de quinze anos, operado no serviço de urgência por amputação traumática da perna esquerda. Revemos a fisiopatologia, o padrão radiológico, potenciais factores de risco e medidas preventivas desta complicação respiratória pós-anestésica.Negative pressure pulmonary oedema is an uncommon complication of traqueal extubation (≈ 0,1%¹ mostly caused by acute upper airway obs truction. Upper airway obstruction from glottis closure leads to marked inspiratory effort, which generates negative intrathoracic pressure transmitting to pulmonary interstitium, and inducing fluid transudation from pulmonary capillary bed1-5. We report a case of post-extubation pulmonary oedema in a fifteen years old patient, submitted to surgery following traumatic amputation of his left leg. We review the pathophysiology, radiological findings, potential risk factors and preventive measures of this post-anaesthetic respiratory complication.

  14. [Gastric vascular lesions in cirrhosis: gastropathy and antral vascular ectasia].

    Science.gov (United States)

    Casas, Meritxell; Calvet, Xavier; Vergara, Mercedes; Bella, Maria Rosa; Junquera, Félix; Martinez-Bauer, Eva; Campo, Rafael

    2015-02-01

    Portal hypertensive gastropathy (GHP) is a complication of portal hypertension usually associated with liver cirrhosis. The pathogenesis is unclear but the presence of portal hypertension is an essential factor for its development. GHP may be asymptomatic or present as gastrointestinal bleeding or iron deficiency anemia. Endoscopic lesions vary from a mosaic pattern to diffuse red spots; the most common location is the fundus. Treatment is indicated when there is acute or chronic bleeding, as secondary prophylaxis. There is insufficient evidence to recommend primary prophylaxis in patients who have never bled. Drugs that decrease portal pressure, such as non-cardioselective beta-blockers, and/or endoscopic ablative treatments, such as argon-beam coagulation, may be used. The role of transarterial intrahepatic portosystemic shunt) or bypass surgery has been insufficiently analyzed. Antral vascular ectasia (EVA) is a rare entity in liver cirrhosis, whose pathophysiology is still unknown. Clinical presentation is similar to that of GHP and endoscopy usually shows red spots in the antrum. Biopsy is often required to differentiate EVA from GHP. There is no effective medical therapy, so endoscopic ablative therapy and, in severe cases, antrectomy are recommended. Copyright © 2014 Elsevier España, S.L.U. and AEEH y AEG. All rights reserved.

  15. Comportamiento del infarto agudo del miocardio en personas con diabetes mellitus de la provincia Granma Situation of the acute myocardial infarction in persons with diabetes mellitus in Granma province

    Directory of Open Access Journals (Sweden)

    Eduardo René Valdés Ramos

    2012-08-01

    Full Text Available Antecedentes: la diabetes mellitus, además de ser un factor de riesgo para el infarto agudo del miocardio, parece conferir per se un peor pronóstico en los pacientes con esta entidad. Objetivo: evaluar el comportamiento del infarto agudo del miocardio en personas con diabetes mellitus de la provincia de Granma. Métodos: se realizó un estudio transversal y descriptivo con 159 pacientes que ingresaron en la Unidad de Cuidados Intensivos Coronarios del Hospital "Carlos Manuel de Céspedes", de Bayamo, Granma, con diagnóstico de infarto agudo del miocardio, en el período comprendido entre enero de 2010 y junio de 2011. De ellos, 39 con diabetes mellitus y 120 sin ella. De las historias clínicas se extrajeron los datos de las variables demográficas, clínicas y metabólicas estudiadas. Resultados: en los casos con diabetes mellitus el porcentaje de infartos extensos y sin dolor precordial fue superior a los no diabéticos, sin llegar a ser estadísticamente significativo (p= 0,3283 y p= 0,1066. Los pacientes diabéticos presentaron 2,8 veces más posibilidad de sufrir una complicación eléctrica que aquellos sin diabetes mellitus (p= 0,0121. No hubo relación significativa entre las complicaciones mecánicas del infarto agudo del miocardio y la presencia de diabetes mellitus (p= 0,4104. El número de defunciones fue significativamente mayor en los casos con diabetes mellitus, que en los no diabéticos (p= 0,0124. Los niveles de glucemia al ingreso estuvieron significativamente más elevados en los casos complicados y fallecidos, tanto en los diabéticos como en los no diabéticos. Conclusiones: el infarto agudo del miocardio, en los pacientes diabéticos de nuestro medio, con frecuencia se presenta sin dolor precordial, extenso, con complicaciones eléctricas y asociado con una elevada mortalidad. La hiperglucemia al ingreso está relacionada con un incremento de la morbilidad y la mortalidad del infarto agudo del miocardio

  16. Comparing Levels of Anxiety During Bed and Shower Baths in Patients with Acute Myocardial Infarction Comparación del nivel de ansiedad entre el baño de aspersión y el realizado en la cama en pacientes con infarto agudo del miocardio Comparação do nível de ansiedade entre o banho de aspersão e o de leito em pacientes com infarto agudo do miocárdio

    Directory of Open Access Journals (Sweden)

    Juliana de Lima Lopes

    2010-04-01

    Full Text Available This study compared the levels of anxiety presented by patients with acute myocardial infarction in bed and shower baths and the influence of antecedent variables: age, gender, medications, previous hospitalization and/or bed bath, patients' preference regarding the professional's gender, risk factors and anxiety-traits. This crossover study was conducted between February and August 2007 in coronary units. The sample was composed of 71 patients with acute myocardial infarction. The State-Trait Anxiety Inventory (STAI was applied before the baths (bed and shower baths, immediately after the baths and twenty minutes after the second evaluation. Results revealed that patients were more anxious in the bed bath than in the shower in the three assessments (p Este estudio tuvo como objetivo comparar los niveles de ansiedad, generados en el baño en la cama y en el de aspersión, en pacientes con infarto agudo del miocardio, así como la influencia de las variables antecedentes: edad, sexo, medicaciones, internación y/o baño en la cama previo, preferencia del paciente en cuanto al sexo del profesional, factores de riesgo y la ansiedad de trazo. Esta investigación es un estudio cross-over, realizado entre febrero y agosto de 2007, en Unidades Coronarias. La muestra fue constituida por 71 pacientes con infarto agudo del miocardio. El instrumento utilizado fue el IDATE-estado, siendo aplicado antes de los baños (cama y aspersión, inmediatamente después de los baños y veinte minutos después de la segunda evaluación. Los resultados mostraron que los pacientes quedaron más ansiosos cuando realizaron su baño en la cama que cuando realizaron el baño de aspersión, en las tres evaluaciones (pEste estudo teve como objetivo comparar os níveis de ansiedade, gerados no banho no leito e naquele de aspersão, em pacientes com infarto agudo do miocárdio, bem como a influência de variáveis antecedentes: idade, sexo, medicações, internação e/ou banho

  17. Vascular elastic photoacoustic tomography in humans

    Science.gov (United States)

    Hai, Pengfei; Zhou, Yong; Liang, Jinyang; Li, Chiye; Wang, Lihong V.

    2016-03-01

    Quantification of vascular elasticity can help detect thrombosis and prevent life-threatening conditions such as acute myocardial infarction or stroke. Here, we propose vascular elastic photoacoustic tomography (VE-PAT) to measure vascular elasticity in humans. VE-PAT was developed by incorporating a linear-array-based photoacoustic computed tomography system with a customized compression stage. By measuring the deformation of blood vessels under uniaxial loading, VE-PAT was able to quantify the vascular compliance. We first demonstrated the feasibility of VE-PAT in blood vessel phantoms. In large vessel phantoms, VE-PAT detected a decrease in vascular compliance due to simulated thrombosis, which was validated by a standard compression test. In small blood vessel phantoms embedded 3 mm deep in gelatin, VE-PAT detected elasticity changes at depths that are difficult to image using other elasticity imaging techniques. We then applied VE-PAT to assess vascular compliance in a human subject and detected a decrease in vascular compliance when an occlusion occurred downstream from the measurement point, demonstrating the potential of VE-PAT in clinical applications such as detection of deep venous thrombosis.

  18. [A new specialty is born: Vascular medicine].

    Science.gov (United States)

    Laroche, J-P

    2016-05-01

    On the 4th of December 2015, the French authorities officially recognized the birth of a specialty in vascular medicine entitled CO-DES cardiology-vascular/vascular Medicine. France is the 7th country to obtain this specialty after Switzerland, Germany, Austria, Czech Republic, Slovakia and Slovenia, six countries in the EEC. It has taken years to achieve a long but exciting experience: we went from hopes to disappointments, sometimes with the blues, but lobbying helping… with sustained confidence. This article tells the story of 30 years of struggle to achieve this vascular medicine specialty. Gaston Bachelard wrote: "Nothing is obvious, nothing is given, all is built." For the construction of vascular medicine, we had to overcome many obstacles, nothing was given to us, everything was conquered. Beware "The specialist is one who knows more and more things about an increasingly restricted field, up to 'knowing everything about nothing"' recalled Ralph Barton Ferry, philosopher; so there is room for modesty and humility but also convictions. The physical examination will remain the basis of our exercise. But let us recall the contributions of all those vascular physicians who practiced in the past, together with those currently active, who built day after day, year after year, a vascular medicine of quality. It is because of the trust of our colleagues and our patients that we can occupy the place that is ours today. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  19. Diagnosis and management of vascular diseases

    International Nuclear Information System (INIS)

    Fan Xindong; Zheng Lianzhou

    2011-01-01

    Vascular disorders mainly include hemangiomas and vascular malformations, and constitute some of the most difficult diagnostic and therapeutic enigmas that can be encountered in the clinical practice. The clinical presentations are extremely variable and can range from an asymptomatic birthmark to life-threatening congestive heart failure. Attributing any of these extremely varied symptoms that a patients may present with to a vascular malformation may be a challenge to the most experienced clinical. This problem is compounded by the extreme rarity of these vascular lesions. If a clinician meets such a patient once every few years, it will be extremely difficult for the physicians to gain a steep learning curve. In such circumstances, it is difficult to formulate a standard of diagnosis and treatment for these vascular disorders. This paper aims to make a comprehensive and detailed description of the classification and diagnosis of the vascular disorders, the common used embolization agents, the concepts of interventional diagnosis and management and the therapies of various hemangiomas and vascular malformations. (authors)

  20. Vascular inflammatory cells in hypertension

    Directory of Open Access Journals (Sweden)

    David G. Harrison

    2012-05-01

    Full Text Available Hypertension is a common disorder with uncertain etiology. In the last several years, it has become evident that components of both the innate and adaptive immune system play an essential role in hypertension. Macrophages and T cells accumulate in the perivascular fat, the heart and the kidney of hypertensive patients and in animals with experimental hypertension. Various immunosuppressive agents lower blood pressure and prevent end-organ damage. Mice lacking lymphocytes are protected against hypertension, and adoptive transfer of T cells, but not B cells in the animals restores their blood pressure response to stimuli such as angiotensin II or high salt. Recent studies have shown that mice lacking macrophages have blunted hypertension in response to angiotensin II and that genetic deletion of macrophages markedly reduces experimental hypertension. Dendritic cells have also been implicated in this disease. Many hypertensive stimuli have triggering effects on the central nervous system and signals arising from the circumventricular organ seem to promote inflammation. Studies have suggested that central signals activate macrophages and T cells, which home to the kidney and vasculature and release cytokines, including IL-6 and IL-17, which in turn cause renal and vascular dysfunction and lead to blood pressure elevation. These recent discoveries provide a new understanding of hypertension and provide novel therapeutic opportunities for treatment of this serious disease.

  1. Imaging evaluation of fetal vascular anomalies

    International Nuclear Information System (INIS)

    Calvo-Garcia, Maria A.; Kline-Fath, Beth M.; Koch, Bernadette L.; Laor, Tal; Adams, Denise M.; Gupta, Anita; Lim, Foong-Yen

    2015-01-01

    Vascular anomalies can be detected in utero and should be considered in the setting of solid, mixed or cystic lesions in the fetus. Evaluation of the gray-scale and color Doppler US and MRI characteristics can guide diagnosis. We present a case-based pictorial essay to illustrate the prenatal imaging characteristics in 11 pregnancies with vascular malformations (5 lymphatic malformations, 2 Klippel-Trenaunay syndrome, 1 venous-lymphatic malformation, 1 Parkes-Weber syndrome) and vascular tumors (1 congenital hemangioma, 1 kaposiform hemangioendothelioma). Concordance between prenatal and postnatal diagnoses is analyzed, with further discussion regarding potential pitfalls in identification. (orig.)

  2. Imaging evaluation of fetal vascular anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Calvo-Garcia, Maria A.; Kline-Fath, Beth M.; Koch, Bernadette L.; Laor, Tal [MLC 5031 Cincinnati Children' s Hospital Medical Center, Department of Radiology, Cincinnati, OH (United States); Adams, Denise M. [Cincinnati Children' s Hospital Medical Center, Department of Pediatrics and Hemangioma and Vascular Malformation Center, Cincinnati, OH (United States); Gupta, Anita [Cincinnati Children' s Hospital Medical Center, Department of Pathology, Cincinnati, OH (United States); Lim, Foong-Yen [Cincinnati Children' s Hospital Medical Center, Pediatric Surgery and Fetal Center of Cincinnati, Cincinnati, OH (United States)

    2015-08-15

    Vascular anomalies can be detected in utero and should be considered in the setting of solid, mixed or cystic lesions in the fetus. Evaluation of the gray-scale and color Doppler US and MRI characteristics can guide diagnosis. We present a case-based pictorial essay to illustrate the prenatal imaging characteristics in 11 pregnancies with vascular malformations (5 lymphatic malformations, 2 Klippel-Trenaunay syndrome, 1 venous-lymphatic malformation, 1 Parkes-Weber syndrome) and vascular tumors (1 congenital hemangioma, 1 kaposiform hemangioendothelioma). Concordance between prenatal and postnatal diagnoses is analyzed, with further discussion regarding potential pitfalls in identification. (orig.)

  3. Vascular ring complicates accidental button battery ingestion.

    Science.gov (United States)

    Mercer, Ronald W; Schwartz, Matthew C; Stephany, Joshua; Donnelly, Lane F; Franciosi, James P; Epelman, Monica

    2015-01-01

    Button battery ingestion can lead to dangerous complications, including vasculoesophageal fistula formation. The presence of a vascular ring may complicate battery ingestion if the battery lodges at the level of the ring and its important vascular structures. We report a 4-year-old boy with trisomy 21 who was diagnosed with a vascular ring at the time of button battery ingestion and died 9 days after presentation due to massive upper gastrointestinal bleeding from esophageal erosion and vasculoesophageal fistula formation. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. [Localized purpura revealing vascular prosthetic graft infection].

    Science.gov (United States)

    Boureau, A S; Lescalie, F; Cassagnau, E; Clairand, R; Connault, J

    2013-07-01

    Prosthetic graft infection after vascular reconstruction is a rare but serious complication. We report a case of infection occurring late after implantation of an iliofemoral prosthetic vascular graft. The Staphylococcus aureus infection was revealed by vascular purpura localized on the right leg 7 years after implantation of a vascular prosthesis. This case illustrates an uncommonly late clinical manifestation presenting as an acute infection 7 years after the primary operation. In this situation, the presentation differs from early infection, which generally occurs within the first four postoperative months. Diagnosis and treatment remain a difficult challenge because prosthetic graft infection is a potentially life-threatening complication. Morbidity and mortality rates are high. Here we detail specific aspects of the clinical and radiological presentation. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  5. Vascular function in health, hypertension, and diabetes

    DEFF Research Database (Denmark)

    Nyberg, Michael Permin; Gliemann, Lasse; Hellsten, Ylva

    2015-01-01

    muscle, which can affect muscle function. Central aspects in the vascular impairments are alterations in the formation of prostacyclin, the bioavailability of NO and an increased formation of vasoconstrictors and reactive oxygen species (ROS). Regular physical activity effectively improves vascular......, the increase in muscle blood flow required for oxygen supply during exercise is achieved through a substantial increase in vasodilators locally formed in the active muscle tissue that overcome the vasoconstrictor signals. Most of the vasodilator signals are mediated via endothelial cells, which lead...... to the formation of vasodilators such as nitric oxide (NO) and prostacyclin. In essential hypertension and type II diabetes, the endothelial function and regulation of vascular tone is impaired with consequent increases in peripheral vascular resistance and inadequate regulation of oxygen supply to the skeletal...

  6. Human genetics of diabetic vascular complications

    Indian Academy of Sciences (India)

    Abstract. Diabetic vascular complications (DVC) affecting several important organ systems of human body such as the ..... cohort with nominal significance, and a recent meta-analysis ..... Whereas it is generally thought that lysine acetylation is.

  7. Incorporating simulation in vascular surgery education.

    Science.gov (United States)

    Bismuth, Jean; Donovan, Michael A; O'Malley, Marcia K; El Sayed, Hosam F; Naoum, Joseph J; Peden, Eric K; Davies, Mark G; Lumsden, Alan B

    2010-10-01

    The traditional apprenticeship model introduced by Halsted of "learning by doing" may just not be valid in the modern practice of vascular surgery. The model is often criticized for being somewhat unstructured because a resident's experience is based on what comes through the "door." In an attempt to promote uniformity of training, multiple national organizations are currently delineating standard curricula for each trainee to govern the knowledge and cases required in a vascular residency. However, the outcomes are anything but uniform. This means that we graduate vascular specialists with a surprisingly wide spectrum of abilities. Use of simulation may benefit trainees in attaining a level of technical expertise that will benefit themselves and their patients. Furthermore, there is likely a need to establish a simulation-based certification process for graduating trainees to further ascertain minimum technical abilities. Copyright © 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.

  8. Audit of the Danish national vascular database

    DEFF Research Database (Denmark)

    Levi-Mazloum, Niels Donald; Jensen, L P; Schroeder, T V

    1996-01-01

    The accuracy of data contained in the Danish vascular database was compared with the case notes. A total of 100 case notes were reviewed for 11 pertinent variables in the database. A high error rate ranging from 2 to 34% was found. Also, approximately 10% of patients had never been entered into t...... into the vascular database. Further improvement of the Danish vascular database is necessary for its use as basis for reporting results.......The accuracy of data contained in the Danish vascular database was compared with the case notes. A total of 100 case notes were reviewed for 11 pertinent variables in the database. A high error rate ranging from 2 to 34% was found. Also, approximately 10% of patients had never been entered...

  9. Vascular adaptation to physical inactivity in humans.

    NARCIS (Netherlands)

    Bleeker, M.W.P.

    2006-01-01

    This thesis presents studies on vascular adaptation to physical inactivity and deconditioning. Although it is clear that physical inactivity is an important risk factor for cardiovascular disease, the underlying physiological mechanisms have not yet been elucidated. In contrast to physical

  10. Extracellular Matrix Molecules Facilitating Vascular Biointegration

    Directory of Open Access Journals (Sweden)

    Martin K.C. Ng

    2012-08-01

    Full Text Available All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy. A range of biomolecules in the subendothelial space have been shown to play critical roles in local regulation of thrombosis, endothelial growth and smooth muscle cell proliferation, making these attractive candidates for modulation of vascular device biointegration. However, classically used biomaterial coatings, such as fibronectin and laminin, modulate only one of these components; enhancing endothelial cell attachment, but also activating platelets and triggering thrombosis. This review examines a subset of extracellular matrix molecules that have demonstrated multi-faceted vascular compatibility and accordingly are promising candidates to improve the biointegration of vascular biomaterials.

  11. Lipidomics in vascular health: current perspectives.

    Science.gov (United States)

    Kolovou, Genovefa; Kolovou, Vana; Mavrogeni, Sophie

    2015-01-01

    Identifying the mechanisms that convert a healthy vascular wall to an atherosclerotic wall is of major importance since the consequences may lead to a shortened lifespan. Classical risk factors (age, smoking, obesity, diabetes mellitus, hypertension, and dyslipidemia) may result in the progression of atherosclerotic lesions by processes including inflammation and lipid accumulation. Thus, the evaluation of blood lipids and the full lipid complement produced by cells, organisms, or tissues (lipidomics) is an issue of importance. In this review, we shall describe the recent progress in vascular health research using lipidomic advances. We will begin with an overview of vascular wall biology and lipids, followed by a short analysis of lipidomics. Finally, we shall focus on the clinical implications of lipidomics and studies that have examined lipidomic approaches and vascular health.

  12. Lower limb vascular dysfunction in cyclists

    Directory of Open Access Journals (Sweden)

    Thiago Ayala Melo Di Alencar

    2013-06-01

    Full Text Available Sports-related vascular insufficiency affecting the lower limbs is uncommon, and early signs and symptoms can be confused with musculoskeletal injuries. This is also the case among professional cyclists, who are always at the threshold between endurance and excess training. The aim of this review was to analyze the occurrence of vascular disorders in the lower limbs of cyclists and to discuss possible etiologies. Eighty-five texts, including papers and books, published from 1950 to 2012, were used. According to the literature reviewed, some cyclists receive a late diagnosis of vascular dysfunction due to a lack of familiarity of the medical team with this type of dysfunction. Data revealed that a reduced blood flow in the external iliac artery, especially on the left, is much more common than in the femoral and popliteal arteries, and that vascular impairment is responsible for the occurrence of early fatigue and reduced performance in cycling.

  13. Laser-assisted vascular anastomosis

    Science.gov (United States)

    Kao, Race L.; Tsao-Wu, George; Magovern, George J.

    1990-06-01

    The milliwatt CO2 laser and a thermal activated binding compound (20% serum albumin) were used for microvascular anastomoses. Under general anesthesia, the femoral arteries (0.7 to 1.0 mm diameter) of 6 rats were isolated. After the left femoral artery in each rat was clamped and transected, the vessel was held together with 3 equidistant 10-0 Xomed sutures. The cut edges were coated 3 to 4 times with the albumin solution and sealed with the CO2 laser (power density = 120 W/cm2). The binding compound solidified to a translucent tensile substance which supported the anastomosis until self healing and repair were achieved. The right femoral artery was used as sham operated control. Complete hemostasis and patency were observed in every case immediately and at 1, 3, and 6 months following surgery. The binding compound absorbed most of the laser energy thus minimizing thermal injury to the underlying tissue. Mongrel dogs weighing 28 to 33 kg were anesthetized and prepared for sterile surgical procedures. In 5 dogs, the femoral and jugular veins were exposed, transected, and anastomosed using a CO2 laser (Sharplan 1040) with the binding compound. In another 12 dogs, cephalic veins were isolated and used for aortocoronary artery bypass procedures. The Sharplan 1040 CO2 laser and 20% albumin solution were utilized to complete the coronary anastomoses in 6 dogs, and 6 dogs were used as controls by suturing the vessels. Again, hemostasis, patency, and minimal tissue damage were observed immediately and 6 weeks after the procedures. Improved surgical results, reduced operating time, minimized tissue damage, and enhanced anastomotic integrity are the advantages of laser assisted vascular anastomosis with a thermal activated binding compound.

  14. The vascular surgery workforce: a survey of consultant vascular surgeons in the UK, 2014.

    Science.gov (United States)

    Harkin, D W; Beard, J D; Shearman, C P; Wyatt, M G

    2015-04-01

    The purpose of this study was to describe the demographics, training, and practice characteristics of consultant vascular surgeons across the UK to provide an assessment of current, and inform future prediction of workforce needs. A questionnaire was developed using a modified Delphi process to generate questionnaire items. The questionnaire was emailed to all consultant vascular surgeons (n = 450) in the UK who were members of the Vascular Society of Great Britain & Ireland. 352 consultant vascular surgeons from 95 hospital trusts across the UK completed the survey (78% response rate). The mean age was 50.6 years old, the majority (62%) were mid-career, but 24% were above the age of 55. Currently, 92% are men and only 8% women. 93% work full-time, with 60% working >50 hours, and 21% working >60 hours per week. The average team was 5 to 6 (range 2-10) vascular surgeons, with 23% working in a large team of ≥8. 17% still work in small teams of ≤3. Over 90% of consultant vascular surgeons perform the major index vascular surgery procedures (aneurysm repair, carotid endarterectomy, infra-inguinal bypass, amputation). While 84% perform standard endovascular abdominal aortic aneurysm repair (EVAR), <50% perform more complex endovascular aortic therapy. The majority of vascular surgeons "like their job" (85%) and are "satisfied" (69%) with their job. 34% of consultant vascular surgeons indicated they were "extremely likely" to retire within the next 10 years. This study provides the first detailed analysis of the new specialty of vascular surgery as practiced in the UK. There is a need to plan for a significant expansion in the consultant vascular surgeon workforce in the UK over the next 10 years to maintain the status quo. Copyright © 2014 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

  15. Biomimicry, vascular restenosis and coronary stents.

    Science.gov (United States)

    Schwartz, R S; van der Giessen, W J; Holmes, D R

    1998-01-01

    Biomimicry is in its earliest stages and is being considered in the realm of tissue engineering. If arterial implants are to limit neointimal thickening, purely passive structures cannot succeed. Bioactivity must be present, either by pharmacologic intervention or by fabricating a 'living stent' that contains active cellular material. As tissue engineering evolves, useful solutions will emerge from applying this knowledge directly to vascular biologic problems resulting from angioplasty, stenting, and vascular prosthesis research.

  16. The current role of vascular stents.

    Science.gov (United States)

    Busquet, J

    1993-09-01

    The limitations of percutaneous balloon angioplasty have favoured the development and the use of vascular endoprostheses or stents. These thin-walled metal devices maintain after expansion, an optimal and constant diameter for the vascular lumen. Restenosis, dissection, abrupt closure, residual stenosis or re-opened total occlusion represent appropriate indications for stenting. A large experience with non-coronary application of stents is currently available in iliac, femoro-popliteal and renal arteries, aorta, large veins.

  17. Vascular colitis: a report of two cases

    Energy Technology Data Exchange (ETDEWEB)

    Park, Chan Il; Han, Chang Yul; Han, Man Chung; Choo, Dong Woon [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1973-04-15

    The authors report two cases of vascular colitis in Korean with a review of literature. Case I, 20 years old male had severe abdominal pain and bloody diarrhea. Case II was 57 years old male and complained severe abdominal pain. Barium enema colon study on each cases disclosed typical thumbprinting appearance of involved segment. Predisposing factor in case I appeared to be anaphylactoid purpura, and in case II distal obstruction due to adenocarcinoma. The mechanism of vascular was briefly discussed.

  18. Robotic vascular resections during Whipple procedure.

    Science.gov (United States)

    Allan, Bassan J; Novak, Stephanie M; Hogg, Melissa E; Zeh, Herbert J

    2018-01-01

    Indications for resection of pancreatic cancers have evolved to include selected patients with involvement of peri-pancreatic vascular structures. Open Whipple procedures have been the standard approach for patients requiring reconstruction of the portal vein (PV) or superior mesenteric vein (SMV). Recently, high-volume centers are performing minimally invasive Whipple procedures with portovenous resections. Our institution has performed seventy robotic Whipple procedures with concomitant vascular resections. This report outlines our technique.

  19. Effects of ouabain on vascular reactivity

    Directory of Open Access Journals (Sweden)

    Vassallo D.V.

    1997-04-01

    Full Text Available Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been proposed to increase vascular resistance and induce hypertension. This substance acts on the a-subunit of Na+,K+-ATPase inhibiting the Na+-pump activity. In the vascular smooth muscle this effect leads to intracellular Na+ accumulation that reduces the activity of the Na+/Ca2+ exchanger and to an increased vascular tone. It was also suggested that circulating ouabain, even in the nanomolar range, sensitizes the vascular smooth muscle to vasopressor substances. We tested the latter hypothesis by studying the effects of ouabain in the micromolar and nanomolar range on phenylephrine (PE-evoked pressor responses. The experiments were performed in normotensive and hypertensive rats in vivo, under anesthesia, and in perfused rat tail vascular beds. The results showed that ouabain pretreatment increased the vasopressor responses to PE in vitro and in vivo. This sensitization after ouabain treatment was also observed in hypertensive animals which presented an enhanced vasopressor response to PE in comparison to normotensive animals. It is suggested that ouabain at nanomolar concentrations can sensitize vascular smooth muscle to vasopressor stimuli possibly contributing to increased tone in hypertension

  20. 3D bioprinting for vascularized tissue fabrication

    Science.gov (United States)

    Richards, Dylan; Jia, Jia; Yost, Michael; Markwald, Roger; Mei, Ying

    2016-01-01

    3D bioprinting holds remarkable promise for rapid fabrication of 3D tissue engineering constructs. Given its scalability, reproducibility, and precise multi-dimensional control that traditional fabrication methods do not provide, 3D bioprinting provides a powerful means to address one of the major challenges in tissue engineering: vascularization. Moderate success of current tissue engineering strategies have been attributed to the current inability to fabricate thick tissue engineering constructs that contain endogenous, engineered vasculature or nutrient channels that can integrate with the host tissue. Successful fabrication of a vascularized tissue construct requires synergy between high throughput, high-resolution bioprinting of larger perfusable channels and instructive bioink that promotes angiogenic sprouting and neovascularization. This review aims to cover the recent progress in the field of 3D bioprinting of vascularized tissues. It will cover the methods of bioprinting vascularized constructs, bioink for vascularization, and perspectives on recent innovations in 3D printing and biomaterials for the next generation of 3D bioprinting for vascularized tissue fabrication. PMID:27230253

  1. Vascular retraction driven by matrix softening

    Science.gov (United States)

    Valentine, Megan

    We recently discovered we can directly apply physical forces and monitor the downstream responses in a living organism in real time through manipulation of the blood vessels of a marine organism called, Botryllus schlosseri. The extracellular matrix (ECM) plays a key role in regulating vascular growth and homeostasis in Botryllus,a basal chordate which has a large, transparent extracorporeal vascular network that can encompass areas >100 cm2. We have determined that lysyl oxidase 1 (LOX1), which is responsible for cross-linking collagen, is expressed in all vascular cells and is critically important for vascular maintenance. Inhibition of LOX1 activity in vivo by the addition of a specific inhibitor, ß-aminopropionitrile (BAPN), caused a rapid, global regression of the entire vascular bed, with some vessels regressing >10 mm within 16 hrs. In this talk, I will discuss the molecular and cellular origins of this systemic remodeling event, which hinges upon the ability of the vascular cells to sense and respond to mechanical signals, while introducing this exciting new model system for studies of biological physics and mechanobiology. Collaborators: Anthony DeTomaso, Delany Rodriguez, Aimal Khankhel (UCSB).

  2. [Vascular aging, arterial hypertension and physical activity].

    Science.gov (United States)

    Schmidt-Trucksäss, A; Weisser, B

    2011-11-01

    The present review delineates the significance of intima-media-thickness, arterial stiffness and endothelial function for vascular aging. There is profound evidence for an increase in intima-media-thickness and vascular stiffness not only during healthy aging but induced also by cardiovascular risk factors. There is a central role of arterial hypertension for this progression in both structural factors. In addition, both parameters are strongly associated with cardiovascular risk. Endothelial function measured as postischemic flow-mediated vasodilatation is a functional parameter which is decreased both in healthy aging and by cardiovascular risk factors. Physical activity modifies the influence of aging and risk factors on endothelial function. A positive influence of endurance exercise on vascular stiffness and endothelial function has been demonstrated in numerous studies. In long-term studies, regular physical activity has been shown to reduce the progression of intima-media-thickness. Thus, arterial hypertension accelerates vascular aging, while physical activity has a positive influence on a variety of vascular parameters associated with vascular aging. © Georg Thieme Verlag KG Stuttgart · New York.

  3. Vascular Adventitia Calcification and Its Underlying Mechanism.

    Directory of Open Access Journals (Sweden)

    Na Li

    Full Text Available Previous research on vascular calcification has mainly focused on the vascular intima and media. However, we show here that vascular calcification may also occur in the adventitia. The purpose of this work is to help elucidate the pathogenic mechanisms underlying vascular calcification. The calcified lesions were examined by Von Kossa staining in ApoE-/- mice which were fed high fat diets (HFD for 48 weeks and human subjects aged 60 years and older that had died of coronary heart disease, heart failure or acute renal failure. Explant cultured fibroblasts and smooth muscle cells (SMCswere obtained from rat adventitia and media, respectively. After calcification induction, cells were collected for Alizarin Red S staining. Calcified lesions were observed in the aorta adventitia and coronary artery adventitia of ApoE-/-mice, as well as in the aorta adventitia of human subjects examined. Explant culture of fibroblasts, the primary cell type comprising the adventitia, was successfully induced for calcification after incubation with TGF-β1 (20 ng/ml + mineralization media for 4 days, and the phenotype conversion vascular adventitia fibroblasts into myofibroblasts was identified. Culture of SMCs, which comprise only a small percentage of all cells in the adventitia, in calcifying medium for 14 days resulted in significant calcification.Vascular calcification can occur in the adventitia. Adventitia calcification may arise from the fibroblasts which were transformed into myofibroblasts or smooth muscle cells.

  4. Características clínicas, angiográficas y desenlaces clínicos en adultos mayores de 65 años con síndrome coronario agudo sin elevación del segmento ST

    Directory of Open Access Journals (Sweden)

    James Díaz

    2017-09-01

    Discusión: Los pacientes de edad mayor con síndrome coronario agudo sin elevación del ST tienen características similares a las reportadas en publicaciones de otras latitudes. Sin embargo, a diferencia de lo reportado en la literatura internacional no se logró demostrar que la edad mayor a 65 años constituya un factor de riesgo independiente para desenlaces clínicos adversos en esta población.

  5. Patterns of peripheral vascular diseases at Muhimbili National hospital

    African Journals Online (AJOL)

    diseases) and HIV- vasculitis. A total of 97 patients (63%) were surgically treated. Conclusion: Shortage of vascular surgeons and facilities in our. Country needs to be sorted out to save life to these patients with vascular disorders. Key Words: Peripheral Vascular Diseases, and Shortage of Vascular Services in Tanzania.

  6. Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension

    NARCIS (Netherlands)

    Ghobadi, G.; Bartelds, B.; van der Veen, S. J.; Dickinson, M. G.; Brandenburg, S.; Berger, R. M. F.; Langendijk, J. A.; Coppes, R. P.; van Luijk, P.

    Background Pulmonary arterial hypertension (PAH) is a commonly fatal pulmonary vascular disease that is often diagnosed late and is characterised by a progressive rise in pulmonary vascular resistance resulting from typical vascular remodelling. Recent data suggest that vascular damage plays an

  7. Vascular associated gene variants in patients with preeclampsia

    DEFF Research Database (Denmark)

    Lykke, Jacob A; Bare, Lance A; Olsen, Jørn

    2012-01-01

    Preeclampsia has been linked to subsequent vascular disease with many shared predisposing factors. We investigated the association between severe preeclampsia, and its subtypes, and specific vascular-related polymorphisms.......Preeclampsia has been linked to subsequent vascular disease with many shared predisposing factors. We investigated the association between severe preeclampsia, and its subtypes, and specific vascular-related polymorphisms....

  8. Talk shows, fascinación o rechazo

    Directory of Open Access Journals (Sweden)

    Jorge Acevedo Rojas

    2015-01-01

    Full Text Available Infidelidades, odio, violencia, alcoholismo, mentira y traiciones, entre otras debilidades humanas, han pasado a formar parte de las programaciones de televisión en América Latina, durante la década de los 90 a través de los programas de Talk Shows. Cristina, El Padre Alberto, Laura en América, Mary Tere, entre los más vistos. Da cuenta de lo que hay detrás de estos programas; por qué se muestra la vida íntima; por qué se los dirige a sectores socioeconómicos bajos; por qué los excesos y degradación humana. Será que esta televisión basura está al servicio del poder.

  9. Genes modificadores requeridos en el rechazo del polen en nicotiana /

    OpenAIRE

    Busot González, Grethel Yanet sustentante.

    2009-01-01

     tesis que para obtener el grado de Doctor en Ciencias Bioquímicas, presenta Grethel Yanet Busot González ; asesor Felipe Cruz García. 189, [16] páginas : ilustraciones. Doctorado en Ciencias Bioquímicas UNAM, Facultad de Química, 2009

  10. El vino en el Islam : rechazo y alabanza

    Directory of Open Access Journals (Sweden)

    Paulina López Pita

    2004-01-01

    Full Text Available Partiendo de la idea generalizada de que el vino era una bebida que estaba prohibida para los creyentes musulmanes, en este trabajo nos ocupamos de analizar qué es lo que ocurría en la realidad en el mundo islámico, pudiendo apreciar que era un elemento cuyo consumo ocupaba un lugar preferente entre todos los grupos de población.Assuming the widespread idea that the wine was a forbidden drink for the muslim believers, we analyze what happened in fact in the Islamic world, and realizing that it was a product which its consumption took up a relevant place among all the groups of population.

  11. Sirtuins, Cell Senescence, and Vascular Aging.

    Science.gov (United States)

    Kida, Yujiro; Goligorsky, Michael S

    2016-05-01

    The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT family members have been identified in mammals, from SIRT1, the best studied for its role in vascular aging, to SIRT7. SIRT1 and SIRT2 are localized in the nucleus and cytoplasm. SIRT3, SIRT4, and SIRT5 are mitochondrial, and SIRT6 and SIRT7 are nuclear. Extensive studies have clearly revealed that SIRT proteins regulate diverse cell functions and responses to stressors. Vascular aging involves the aging process (senescence) of endothelial and vascular smooth muscle cells. Two types of cell senescence have been identified: (1) replicative senescence with telomere attrition; and (2) stress-induced premature senescence without telomere involvement. Both types of senescence induce vascular cell growth arrest and loss of vascular homeostasis, and contribute to the initiation and progression of cardiovascular diseases. Previous mechanistic studies have revealed in detail that SIRT1, SIRT3, and SIRT6 show protective functions against vascular aging, and definite vascular function of other SIRTs is under investigation. Thus, direct SIRT modulation and nicotinamide adenine dinucleotide stimulation of SIRT are promising candidates for cardiovascular disease therapy. A small number of pilot studies have been conducted to assess SIRT modulation in humans. These clinical studies have not yet provided convincing evidence that SIRT proteins alleviate morbidity and mortality in patients with cardiovascular diseases. The outcomes of multiple ongoing clinical trials are awaited to define the efficacy of SIRT modulators and SIRT activators in cardiovascular diseases, along with the potential adverse effects of chronic SIRT modulation. Copyright © 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

  12. Progenitor cells in pulmonary vascular remodeling

    Science.gov (United States)

    Yeager, Michael E.; Frid, Maria G.; Stenmark, Kurt R.

    2011-01-01

    Pulmonary hypertension is characterized by cellular and structural changes in the walls of pulmonary arteries. Intimal thickening and fibrosis, medial hypertrophy and fibroproliferative changes in the adventitia are commonly observed, as is the extension of smooth muscle into the previously non-muscularized vessels. A majority of these changes are associated with the enhanced presence of α-SM-actin+ cells and inflammatory cells. Atypical abundances of functionally distinct endothelial cells, particularly in the intima (plexiform lesions), and also in the perivascular regions, are also described. At present, neither the origin(s) of these cells nor the molecular mechanisms responsible for their accumulation, in any of the three compartments of the vessel wall, have been fully elucidated. The possibility that they arise from either resident vascular progenitors or bone marrow–derived progenitor cells is now well established. Resident vascular progenitor cells have been demonstrated to exist within the vessel wall, and in response to certain stimuli, to expand and express myofibroblastic, endothelial or even hematopoietic markers. Bone marrow–derived or circulating progenitor cells have also been shown to be recruited to sites of vascular injury and to assume both endothelial and SM-like phenotypes. Here, we review the data supporting the contributory role of vascular progenitors (including endothelial progenitor cells, smooth muscle progenitor cells, pericytes, and fibrocytes) in vascular remodeling. A more complete understanding of the processes by which progenitor cells modulate pulmonary vascular remodeling will undoubtedly herald a renaissance of therapies extending beyond the control of vascular tonicity and reduction of pulmonary artery pressure. PMID:22034593

  13. Congenital vascular malformations in scintigraphic evaluation

    International Nuclear Information System (INIS)

    Pilecki, Stanisław; Gierach, Marcin; Gierach, Joanna; Świętaszczyk, Cyprian; Junik, Roman; Lasek, Władysław

    2014-01-01

    Congenital vascular malformations are tumour-like, non-neoplastic lesions caused by disorders of vascular tissue morphogenesis. They are characterised by a normal cell replacement cycle throughout all growth phases and do not undergo spontaneous involution. Here we present a scintigraphic image of familial congenital vascular malformations in two sisters. A 17-years-old young woman with a history of multiple hospitalisations for foci of vascular anomalies appearing progressively in the upper and lower right limbs, chest wall and spleen. A Parkes Weber syndrome was diagnosed based on the clinical picture. Due to the occurrence of new foci of malformations, a whole-body scintigraphic examination was performed. A 12-years-old girl reported a lump in the right lower limb present for approximately 2 years, which was clinically identified as a vascular lesion in the area of calcaneus and talus. Phleboscintigraphy visualized normal radiomarker outflow from the feet via the deep venous system, also observed in the superficial venous system once the tourniquets were released. In static and whole-body examinations vascular malformations were visualised in the area of the medial cuneiform, navicular and talus bones of the left foot, as well as in the projection of right calcaneus and above the right talocrural joint. People with undiagnosed disorders related to the presence of vascular malformations should undergo periodic follow-up to identify lesions that may be the cause of potentially serious complications and to assess the results of treatment. Presented scintigraphic methods may be used for both diagnosing and monitoring of disease progression

  14. Gene transfer therapy in vascular diseases.

    Science.gov (United States)

    McKay, M J; Gaballa, M A

    2001-01-01

    Somatic gene therapy of vascular diseases is a promising new field in modern medicine. Recent advancements in gene transfer technology have greatly evolved our understanding of the pathophysiologic role of candidate disease genes. With this knowledge, the expression of selective gene products provides the means to test the therapeutic use of gene therapy in a multitude of medical conditions. In addition, with the completion of genome sequencing programs, gene transfer can be used also to study the biologic function of novel genes in vivo. Novel genes are delivered to targeted tissue via several different vehicles. These vectors include adenoviruses, retroviruses, plasmids, plasmid/liposomes, and oligonucleotides. However, each one of these vectors has inherent limitations. Further investigations into developing delivery systems that not only allow for efficient, targeted gene transfer, but also are stable and nonimmunogenic, will optimize the clinical application of gene therapy in vascular diseases. This review further discusses the available mode of gene delivery and examines six major areas in vascular gene therapy, namely prevention of restenosis, thrombosis, hypertension, atherosclerosis, peripheral vascular disease in congestive heart failure, and ischemia. Although we highlight some of the recent advances in the use of gene therapy in treating vascular disease discovered primarily during the past two years, many excellent studies published during that period are not included in this review due to space limitations. The following is a selective review of practical uses of gene transfer therapy in vascular diseases. This review primarily covers work performed in the last 2 years. For earlier work, the reader may refer to several excellent review articles. For instance, Belalcazer et al. (6) reviewed general aspects of somatic gene therapy and the different vehicles used for the delivery of therapeutic genes. Gene therapy in restenosis and stimulation of

  15. Adiposity, adipocytokines & microvesicles in the etiology of vascular disease

    OpenAIRE

    Kanhai, D.A.N.I.S.

    2013-01-01

    Vascular disease, in this thesis the terms vascular and cardiovascular are used interchangeably, is the number 1 cause of death worldwide. In 2008, 30% of all mortality had a vascular origin. Vascular mortality rates after a first manifestation of vascular disease are decreasing in Western society, which is attributable to better disease awareness, better preventive strategies and better healthcare systems. As mortality rates are decreasing, the number of patients surviving their first vascul...

  16. Causas de la no-trombólisis en el infarto agudo del miocardio y beneficios de su uso Causes of non-thrombolysis in the acute myocardial infarction and benefits from its use

    Directory of Open Access Journals (Sweden)

    Christian Leyva de la Torre

    2005-08-01

    Full Text Available Se realizó un estudio descriptivo con enfoque de riesgo mediante la revisión de las 242 historias clínicas de todos los pacientes egresados vivos o fallecidos con diagnóstico de infarto agudo del miocardio en el Hospital Docente Clinicoquirúrgico "Dr. Salvador Allende" durante el 2002, a fin de determinar las causas principales por las que se difiere el tratamiento trombolítico en esta entidad. Se efectuó la trombólisis al 29,8 % de los pacientes con infarto agudo del miocardio que llegaron a dicha institución; sin embargo, para el 11,6 % de casos no hay justificación de la no aplicación de la trombólisis. Las principales causas de la no aplicación de esta fueron la llegada al hospital pasadas las primeras 12 h del inicio del dolor (17,4 % y la no elevación del segmento ST (11,2 %. La edad mayor de 75 años no constituyó un riesgo de no elección para el tratamiento trombolítico (OR= 1,45 [0,75-2,81 IC= 95 %]; p= 0,267. La mortalidad por infarto agudo del miocardio aun se mantiene elevada con el 26 %. La edad mayor de 75 años (OR= 3,41 (1,83-6,35 IC= 95 %]; p= 0,000, el tiempo de llegada al hospital mayor de 6 h (OR= 2,36 [1,17-4,75 IC= 95 %]; p= 0,014, y la no aplicación del tratamiento trombolítico (OR= 3,82 [1,71-8,53 IC= 95 %]; p= 0,001 constituyeron elementos de riesgo relacionados de forma estadísticamente significativa con la letalidad del infarto. El riego de morir se mantuvo aun en los pacientes en que no se aplicó la trombólisis del subgrupo de mayores de 75 años (OR= 8,04 [1,63-39,69 IC= 95 %]; p= 0,004.A descriptive study with risk approach was undertaken by reviewing 242 medical histories of the living discharged patients or dead patients with diagnosis of acute myocardial infarction at "Dr. Salvador Allende" Clinical and Surgical Teaching Hospital , aimed at determining the main causes for deferring the thrombolytic treatment in this entity. Thrombolysis was performed in 29.8 % of the patients with acute

  17. Acute and chronic pain: a narrative review of the literature Dolor agudo y crónico: revisión narrativa de la literatura Dor aguda e crônica: revisão narrativa da literatura

    Directory of Open Access Journals (Sweden)

    Ana Maria Calil Sallum

    2012-01-01

    Full Text Available The study objectives were to identify the organic, emotional and psychic prevalent consequences in patients with acute and chronic pain and punctuate the main assessment tools for these pains. A narrative review of the literature was conducted using descriptors related to pain measurement, signs and symptoms, totalizing 184 articles. The electronic databases MEDLINE and LILACS were searched from January 2000 to December 2010. The review pointed out a series of conclusive studies about the organic repercussions more frequent in acute and chronic pain conditions and the use of different rating scales for both situations. It is believed that these findings could be of great values for health teams, could contribute with a better practice and with customer satisfaction in the hospital scenario and at home.Los objetivos del estudio fueron identificar las repercusiones orgánicas, emocionales y psíquicas prevalentes en pacientes con dolor agudo y dolor crónico y puntuar los principales instrumentos de evaluación para esos dolores. Se realizó una revisión narrativa de la literatura, utilizándose descriptores relacionados a la medición del dolor, cuidados de enfermería, signos y síntomas, en un total de 184 artículos. Las bases electrónicas investigadas fueron LILACS y MEDLINE, entre enero de 2000 a diciembre de 2010. Esta revisión puntuó una serie de estudios conclusivos sobre las repercusiones orgánicas más frecuentes en los cuadros álgicos agudos y crónicos y el uso de escalas de evaluación distintas para ambas situaciones. Se cree que esos hallazgos podrán ser de gran valía para los equipos de salud y que contribuya con mejores prácticas y satisfacción del cliente en los escenarios intra hospitalario y domiciliario.Os objetivos do estudo foram identificar as repercussões orgânicas, emocionais e psíquicas prevalentes em pacientes com dor aguda e dor crônica e pontuar os principais instrumentos de avaliação para essas dores

  18. Open and endovascular aneurysm repair in the Society for Vascular Surgery Vascular Quality Initiative.

    Science.gov (United States)

    Spangler, Emily L; Beck, Adam W

    2017-12-01

    The Society for Vascular Surgery Vascular Quality Initiative is a patient safety organization and a collection of procedure-based registries that can be utilized for quality improvement initiatives and clinical outcomes research. The Vascular Quality Initiative consists of voluntary participation by centers to collect data prospectively on all consecutive cases within specific registries which physicians and centers elect to participate. The data capture extends from preoperative demographics and risk factors (including indications for operation), through the perioperative period, to outcomes data at up to 1-year of follow-up. Additionally, longer-term follow-up can be achieved by matching with Medicare claims data, providing long-term longitudinal follow-up for a majority of patients within the Vascular Quality Initiative registries. We present the unique characteristics of the Vascular Quality Initiative registries and highlight important insights gained specific to open and endovascular abdominal aortic aneurysm repair. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Preparation and features of polycaprolactone vascular grafts with the incorporated vascular endothelial growth factor

    Energy Technology Data Exchange (ETDEWEB)

    Sevostyanova, V. V., E-mail: sevostyanova.victoria@gmail.com; Khodyrevskaya, Y. I.; Glushkova, T. V.; Antonova, L. V.; Kudryavtseva, Y. A.; Barbarash, O. L.; Barbarash, L. S. [Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo (Russian Federation)

    2015-10-27

    The development of tissue-engineered small-diameter vascular grafts is an urgent issue in cardiovascular surgery. In this study, we assessed how the incorporation of the vascular endothelial growth factor (VEGF) affects morphological and mechanical properties of polycaprolactone (PCL) vascular grafts along with its release kinetics. Vascular grafts were prepared using two-phase electrospinning. In pursuing our aims, we performed scanning electron microscopy, mechanical testing, and enzyme-linked immunosorbent assay. Our results demonstrated the preservation of a highly porous structure and improvement of PCL/VEGF scaffold mechanical properties as compared to PCL grafts. A prolonged VEGF release testifies the use of this construct as a scaffold for tissue-engineered vascular grafts.

  20. Effects of PPARγ ligands on vascular tone.

    Science.gov (United States)

    Salomone, Salvatore; Drago, Filippo

    2012-06-01

    Peroxisome Proliferator-Activated Receptor γ (PPARγ), originally described as a transcription factor for genes of carbohydrate and lipid metabolism, has been more recently studied in the context of cardiovascular pathophysiology. Here, we review the available data on PPARγ ligands as modulator of vascular tone. PPARγ ligands include: thiazolidinediones (used in the treatment of type 2 diabetes mellitus), glitazars (bind and activate both PPARγ and PPARα), and other experimental drugs (still in development) that exploit the chemistry of thiazolidinediones as a scaffold for PPARγ-independent pharmacological properties. In this review, we examine both short (mostly from in vitro data)- and long (mostly from in vivo data)-term effects of PPARγ ligands that extend from PPARγ-independent vascular effects to PPARγ-dependent gene expression. Because endothelium is a master regulator of vascular tone, we have attempted to differentiate between endothelium-dependent and endothelium-independent effects of PPARγ ligands. Based on available data, we conclude that PPARγ ligands appear to influence vascular tone in different experimental paradigms, most often in terms of vasodilatation (potentially increasing blood flow to some tissues). These effects on vascular tone, although potentially beneficial, must be weighed against specific cardiovascular warnings that may apply to some drugs, such as rosiglitazone.

  1. Insulin resistance: vascular function and exercise

    Directory of Open Access Journals (Sweden)

    Moon-Hyon Hwang

    2016-09-01

    Full Text Available Insulin resistance associated with metabolic syndrome and Type 2 diabetes mellitus is an epidemic metabolic disorder, which increases the risk of cardiovascular complications. Impaired vascular endothelial function is an early marker for atherosclerosis, which causes cardiovascular complications. Both experimental and clinical studies indicate that endothelial dysfunction in vasculatures occurs with insulin resistance. The associated physiological mechanisms are not fully appreciated yet, however, it seems that augmented oxidative stress, a physiological imbalance between oxidants and antioxidants, in vascular cells is a possible mechanism involved in various vascular beds with insulin resistance and hyperglycemia. Regardless of the inclusion of resistance exercise, aerobic exercise seems to be beneficial for vascular endothelial function in both large conduit and small resistance vessels in both clinical and experimental studies with insulin resistance. In clinical cases, aerobic exercise over 8 weeks with higher intensity seems more beneficial than the cases with shorter duration and lower intensity. However, more studies are needed in the future to elucidate the physiological mechanisms by which vascular endothelial function is impaired in insulin resistance and improved with aerobic exercise.

  2. Vascular trauma: selected historical reflections from the

    Directory of Open Access Journals (Sweden)

    Rich Norman M

    2011-04-01

    Full Text Available 【Abstract】In the spirit of international exchanges of knowledge with colleagues from all over the world, who are interested in the care and treatment of vascular trauma, we offer selected historical reflections from the western world on vascular trauma. Whereas there are a number of key individuals and a variety of events that are important to us in our writing, we know essentially nothing about what is written by other cultures and, particularly, the Chinese. It is well recognized around the world that Chinese surgeons are among the first to be highly successful in re-plantation of severed extremities, repairing both injured arteries and veins. Also, we recognize that there are contributions in other parts of the world, which are not well known to us collectively. Contributions from the Arabic speaking part of the world come to mind because there is periodic brief reference. We offer our perspective hoping that there will be one or more Chinese surgeons who will offer us the benefit of sharing their perspective on important historical contributions to the managing of vascular trauma outside of the western world, and, particularly, the English speaking literature. Once again, we encourage our colleagues in the Arabic speaking world to provide us with their perspective of the development and management of vascular trauma. Key words: Vascular system injuries; History; Western world; International educational exchange

  3. Arteriographic evaluation, in the perispheric vascular trauma

    International Nuclear Information System (INIS)

    Patino, Jairo Hernando; Granados, Ana Maria; Lopera B, Jorge; Prada W, Angela Maria

    1993-01-01

    136 patients were angiographically studied under the suspicion of perispheric vascular lesion submitted to the radiology department of the San Vicente de Paul University Hospital (H.U.S.VP.) Medellin Colombia. The majority of the patients were young with wounds caused by gunshots (79.4%). the must frequent angiographic indication was the proximity of the wound to a vascular path (44.5%). 63% of the patients with angiography indicative of abnormality needed surgery from which 21% were because of the proximity of the wound to a vascular path and 76% because of the mayor findings when admitted to the hospital. the possible complications as a result of the angiographic procedure were revised only find inc two mayor reactions to the contrast media. there were no late complications. Angiography is highlighting sensitive (100%) specific (98.5%) and secure in the evaluation of patients with perispheric vascular trauma. Due to the high number of false negatives when the physical examination is performed, every patient with a wound near a vascular path must be evaluated angiographically

  4. Endothelial dysfunction in metabolic and vascular disorders.

    Science.gov (United States)

    Polovina, Marija M; Potpara, Tatjana S

    2014-03-01

    Vascular endothelium has important regulatory functions in the cardiovascular system and a pivotal role in the maintenance of vascular health and metabolic homeostasis. It has long been recognized that endothelial dysfunction participates in the pathogenesis of atherosclerosis from early, preclinical lesions to advanced, thrombotic complications. In addition, endothelial dysfunction has been recently implicated in the development of insulin resistance and type 2 diabetes mellitus (T2DM). Considering that states of insulin resistance (eg, metabolic syndrome, impaired fasting glucose, impaired glucose tolerance, and T2DM) represent the most prevalent metabolic disorders and risk factors for atherosclerosis, it is of considerable scientific and clinical interest that both metabolic and vascular disorders have endothelial dysfunction as a common background. Importantly, endothelial dysfunction has been associated with adverse outcomes in patients with established cardiovascular disease, and a growing body of evidence indicates that endothelial dysfunction also imparts adverse prognosis in states of insulin resistance. In this review, we discuss the association of insulin resistance and T2DM with endothelial dysfunction and vascular disease, with a focus on the underlying mechanisms and prognostic implications of the endothelial dysfunction in metabolic and vascular disorders. We also address current therapeutic strategies for the improvement of endothelial dysfunction.

  5. Nanomedicine approaches in vascular disease: a review.

    Science.gov (United States)

    Gupta, Anirban Sen

    2011-12-01

    Nanomedicine approaches have revolutionized the treatment of cancer and vascular diseases, where the limitations of rapid nonspecific clearance, poor biodistribution and harmful side effects associated with direct systemic drug administration can be overcome by packaging the agents within sterically stabilized, long-circulating nanovehicles that can be further surface-modified with ligands to actively target cellular/molecular components of the disease. With significant advancements in genetics, proteomics, cellular and molecular biology and biomaterials engineering, the nanomedicine strategies have become progressively refined regarding the modulation of surface and bulk chemistry of the nanovehicles, control of drug release kinetics, manipulation of nanoconstruct geometry and integration of multiple functionalities on single nanoplatforms. The current review aims to capture the various nanomedicine approaches directed specifically toward vascular diseases during the past two decades. Analysis of the promises and limitations of these approaches will help identify and optimize vascular nanomedicine systems to enhance their efficacy and clinical translation in the future. Nanomedicine-based approaches have had a major impact on the treatment and diagnosis of malignancies and vascular diseases. This review discusses various nanomedicine approaches directed specifically toward vascular diseases during the past two decades, highlighting their advantages, limitations and offering new perspectives on future applications. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Cirurgia de revascularização no infarto agudo do miocárdio Coronary artery bypass following acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Luiz Antônio Castilho Teno

    1990-04-01

    Full Text Available O tratamento do infarto agudo do miocárdio conta, hoje, com um leque de opções terapêuticas, sempre com o objetivo de reduzir o dano ao ventrículo esquerdo, Dentre as possibilidades, a revascularização cirúrgica encontra seu lugar, ligado, principalmente, à reperfusão após trombolíticos e às complicações da angioplastia. No Instituto do Coração da Santa Casa de Ribeirão Preto, no período de julho/87 a julho/89, foram realizadas 262 cirurgias de revascularização do miocárdio, sendo 23 (8,7% na fase aguda do infarto. Destes, 19 eram homens e quatro mulheres, com idade entre 42 e 75 anos, média de 58,5. A indicação cirúrgica compreendeu: persistência da dor em 15 (65% ocasiões, artéria reaberta após trombolítico em cinco (22%, artéria reaberta espontaneamente em dois (9% e comprometimento multiarterial em um (4%. Os fatores associados à precocidade do procedimento cirúrgico foram: ATP complicada com espasmo e oclusão arterial em oito pacientes, uso prévio de trombolítico em sete, ATP sem sucesso em quatro, arritmia cardíaca em dois e choque cardiogênico em um. A localização do IAM ao ECG foi de parede anterior em 14 (60,8% casos e parede inferior em nove (39,2%. Em 18 (78,4% havia presença de onda Q e, nos restantes, ausência. A dosagem de enzimas (CKMB variou de 15 a 104 U, média 58,7 U. A cineventriculografia demonstrou lesão isolada da artéria do IAM em nove (39,1% pacientes, lesão da artéria do IAM + lesão de outras artérias em oito (34,7%, lesão da artéria do IAM + infarto prévio de outra área em três (13% e obstrução total da artéria do IAM + lesão de outras artérias em três (13% casos. O período de tempo entre o início da dor e a cirurgia variou de duas horas a duas semanas, média 4,6 dias. O número de pontes, mamária ou safena, por paciente foi, em média, de 1,7, A proteção miocárdica foi realizada com hipotermia leve e solução cardioplégica cristalóide. A anoxia mioc

  7. The vascular pattern in the flower of some Mesembryanthemaceae: Aptenia cordifolia and Dorotheanthus bellidiformis. The effect of an ontogenetical shifting on the vascular pattern and vascular conservatism

    NARCIS (Netherlands)

    Meulen-Bruijns, van der C.

    1976-01-01

    1. The vascular pattern in the flower at various stages of maturity of Aptenia cordifolia and Dorotheanthus bellidiformis is examined. 2. The vascular pattern of Dorotheanthus has been compared with that of Aptenia: typologically, Dorotheanthus is derived from Aptenia. 3. The vascular pattern of

  8. Vascular training and endovascular practice in Europe

    DEFF Research Database (Denmark)

    Liapis, C.D.; Avgerinos, E.D.; Sillesen, H.

    2009-01-01

    specialties was distributed to a VS educator within 14 European countries. European Vascular and Endovascular Monitor (EVEM) data also were processed to correlate endovascular practice with training models. RESULTS: Fourteen questionnaires were gathered. Vascular training in Europe appears in 3 models: 1....... Mono-specialty (independence): 7 countries, 2. Subspecialty: 5 countries, 3. An existing specialty within general surgery: 2 countries. Independent compared to non-independent certification shortens overall training length (5.9 vs 7.9 years, p=0.006), while increasing overall training devoted......% respectively. Countries with independent vascular certification, despite their lower average endovascular index (procedures per 100,000 population), reported a higher growth rate of aortic endovascular procedures (VS independent 132% vs VS non-independent 87%), within a four-year period (2003-2007). Peripheral...

  9. Intraoperative digital angiography: Peripheral vascular applications

    International Nuclear Information System (INIS)

    Bell, K.; Reifsteck, J.E.; Binet, E.F.; Fleisher, H.J.

    1986-01-01

    Intraoperative digital angiography is the procedure of choice for the peripheral vascular surgeon who wishes to evaluate his results before terminating anesthesia. Two operating suites at the John L. McClellan Memorial Veterans Hospital are equipped with permanent ceiling-mounted Philips C-arm fluoroscopes and share an ADAC 4100 digital angiographic system. In the last 18 months, 40 peripheral vascular intraoperative digital angiographic procedures have been performed, in all but two cases using direct arterial puncture. In 65% of cases, the intraoperative study showed no significant abnormality. In 12.5%, minor abnormalities not requiring reoperation were seen. In 22.5% of cases, the intraoperative digital angiogram revealed a significant abnormality requiring immediate operative revision. None of the patients who underwent reoperation experienced postoperative sequelae. Intraoperative digital angiography is useful in identifying complications of peripheral vascular operations

  10. Viral haemorrhagic fever and vascular alterations.

    Science.gov (United States)

    Aleksandrowicz, P; Wolf, K; Falzarano, D; Feldmann, H; Seebach, J; Schnittler, H

    2008-02-01

    Pathogenesis of viral haemorrhagic fever (VHF) is closely associated with alterations of the vascular system. Among the virus families causing VHF, filoviruses (Marburg and Ebola) are the most fatal, and will be focused on here. After entering the body, Ebola primarily targets monocytes/macrophages and dendritic cells. Infected dendritic cells are largely impaired in their activation potency, likely contributing to the immune suppression that occurs during filovirus infection. Monocytes/macrophages, however, immediately activate after viral contact and release reasonable amounts of cytokines that target the vascular system, particularly the endothelial cells. Some underlying molecular mechanisms such as alteration of the vascular endothelial cadherin/catenin complex, tyrosine phosphorylation, expression of cell adhesion molecules, tissue factor and the effect of soluble viral proteins released from infected cells to the blood stream will be discussed.

  11. Vacuum assisted closure in vascular surgery.

    Science.gov (United States)

    Beno, M; Martin, J; Sager, P

    2011-01-01

    Vacuum assisted closure (VAC-therapy) is a well established method in nearly all surgical disciplines. The aim is to present the efficiency of vacuum assisted closure in the treatment of acute and chronic wounds in patients admitted in the department of vascular surgery. Within the year 2008 there were 59 patients (44 men, 15 women) treated with VAC therapy in our Department of Vascular surgery (Landshut, Germany). VAC was used 22x (37.28 %) in therapy of ulcus cruris (venous, arterial, mixed genesis), 15x (25.42%) in patients with diabetic foot syndrome, 12x (20.33%) in secondary healing wounds and infected wounds, 5x (8.47%) in wounds after several injuries and soft skin tissue infections and 5x (8.47%) in wound infections connected with vascular graft infections after vascular revascularization. VAC therapy seems to be very effective in the management of patients with venous ulcers, especially after a proper surgical treatment (100%), patients with soft skin tissue infections (100%) and secondary healing wounds (100%) especially in combination with MESH-Grafting. In patients with diabetic foot syndrome (80%) and peripheral arterial occlusive disease (72.7%), an evaluation of peripheral blood perfusion and revascularization prior to VAC therapy is often necessary. Although VAC was used 5x in the therapy of infected vascular grafts, successful preservation of infected graft material was observed in only one case (infection of PTFE femoro-popliteal bypass graft). Vacuum assisted closure in vascular surgery proved to be simple and efficient method in therapy of acute and chronic wounds. The efficiency of VAC systems in therapy of infected graft material after revascularization needs further studies (Tab. 3, Ref. 10).

  12. The pathology and pathophysiology of vascular dementia.

    Science.gov (United States)

    Kalaria, Raj N

    2017-12-19

    Vascular dementia (VaD) is widely recognised as the second most common type of dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on wide-ranging clinical, neuropsychological and neuroimaging measures in life but more importantly pathological confirmation. Factors defining subtypes of VaD include the nature and extent of vascular pathologies, degree of involvement of extra and intracranial vessels and the anatomical location of tissue changes as well as time after the initial vascular event. Atherosclerotic and cardioembolic diseases combined appear the most common subtypes of vascular brain injury. In recent years, cerebral small vessel disease (SVD) has gained prominence worldwide as an important substrate of cognitive impairment. SVD is characterised by arteriolosclerosis, lacunar infarcts and cortical and subcortical microinfarcts and diffuse white matter changes, which involve myelin loss and axonal abnormalities. Global brain atrophy and focal degeneration of the cerebrum including medial temporal lobe atrophy are also features of VaD similar to Alzheimer's disease. Hereditary arteriopathies have provided insights into the mechanisms of dementia particularly how arteriolosclerosis, a major contributor of SVD promotes cognitive impairment. Recently developed and validated neuropathology guidelines indicated that the best predictors of vascular cognitive impairment were small or lacunar infarcts, microinfarcts, perivascular space dilation, myelin loss, arteriolosclerosis and leptomeningeal cerebral amyloid angiopathy. While these substrates do not suggest high specificity, VaD is likely defined by key neuronal and dendro-synaptic changes resulting in executive dysfunction and related cognitive deficits. Greater understanding of the molecular pathology is needed to clearly define microvascular disease and vascular substrates of dementia. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Tratamento de uma coorte de pacientes com infarto agudo do miocárdio com supradesnivelamento do segmento ST Tratamiento de una cohorte de pacientes con infarto agudo de miocardio con supradesnivel del segmento ST Treatment of a cohort of patients with acute myocardial infarction and ST-segment elevation

    Directory of Open Access Journals (Sweden)

    Jamil da Silva Soares

    2009-06-01

    Full Text Available FUNDAMENTO: Trombólise e angioplastia transluminal coronariana (ATC primária são técnicas bem estabelecidas, mas grande parte dos pacientes com infarto agudo do miocárdio com supradesnivelamento do segmento ST (IAM com SST não as recebem quando do atendimento hospitalar. OBJETIVO: Descrever tratamentos inicial e final e desfechos de uma coorte com IAM com SST. MÉTODOS: Analisados, da internação até a alta, 158 pacientes com IAM com SST, de uma população total de 351 pacientes internados com (SCA nos hospitais de Campos dos Goytacazes, entre 2004 e 2006. RESULTADOS: Dos 158 pacientes com IAM com SST, 67,7% chegaram ao hospital nos primeiros 180 minutos, 81,3% em 360 minutos e 8,4% após doze horas. Realizados 148 estudos cinecoronariográficos (93,7%. Observadas lesões de mais de 70% em 266 territórios arteriais. Tratamento inicial foi ATC em 41(26%, trombolíticos em 50 (32%, com 80% de sucesso. Tratamento clínico em 67 (42%. Cerca de 35% dos pacientes deveriam ser trombolizados mas não o foram. No tratamento final foram 93 ATCs, 89 delas com sucesso angiográfico (95,7, sangramento 2 (2,2, oclusão subaguda 2 (2,2%, dissecção tronco 1 (1,1, pseudo aneurisma 1 (1,1. Nenhum óbito durante angioplastia; na evolução, houve dois óbitos (2,1%. Doze pacientes submetidos a cirurgia de revascularização miocárdica (CRM. Tratamento clínico 53 (33%, com 11 óbitos (20,7%. Letalidade global 9,5%, consideradas as três formas de tratamento. CONCLUSÃO: Pacientes atendidos em tempo adequado para reperfusão, porém 1/3 deles não recebeu o procedimento. Tratamento predominante foi ATC, com baixa morbidade. Dois óbitos na evolução. Baixa letalidade global.FUNDAMENTO: La trombólisis y la angioplastia transluminal coronaria (ATC primaria son técnicas bien establecidas, sin embargo gran parte de los pacientes con infarto agudo de miocardio con supradesnivel del segmento ST (IAM con SST no las reciben cuando de la atenci

  14. Efeitos agudos de levosimendana e dobutamina na duração do QRS em Pacientes com insuficiência cardíaca Efectos agudos de levosimendana y dobutamina en la duración del QRS en pacientes con insuficiencia cardíaca Acute effects of levosimendan and dobutamine on QRS duration in patients with heart failure

    Directory of Open Access Journals (Sweden)

    Osman Can Yontar

    2010-12-01

    Full Text Available FUNDAMENTO: A levosimendana é um novo agente inotrópico que aumenta a contratilidade cardíaca sem aumentar a captação celular de cálcio, de forma a não causar sobrecarga de cálcio e arritmias relacionadas. Em pacientes com insuficiência cardíaca (IC, a duração prolongada do QRS está associada com um aumento no risco de mortalidade e morte súbita cardíaca. Mudanças estruturais no ventrículo esquerdo podem levar à contração assíncrona, causando atraso de condução e um QRS prolongado no ECG de superfície. OBJETIVO: O objetivo do presente estudo foi comparar os efeitos agudos de levosimendana e dobutamina na duração do QRS em pacientes com IC grave e ritmo sinusal. MÉTODOS: 60 pacientes consecutivos com IC isquêmica foram incluídos no estudo e randomizados em dois grupos para infusão de levosimendana (n=37 ou dobutamina (n=23. 67,2 % eram homens; a média da idade era 66,4 ± 9,2 anos para todos os pacientes. A duração basal do QRS nos grupos levosimendana e dobutamina foi 120,44 ± 23,82 ms vs 116,59 ± 13,80 ms respectivamente. A fração de ejeção do ventrículo esquerdo (FEVE estava diminuída em ambos os grupos (23,15 ± 8,3 vs 24,56 ± 7,5%. RESULTADOS: No grupo levosimendana, a duração do QRS diminuiu do valor basal para 116,47 ± 24,56 ms (p=0,006, enquanto não houve diferença significante no grupo dobutamina (p=0,605. Ambos os medicamentos causaram um aumento na FEVE, mas este foi significante apenas no grupo levosimendana (27,95 ± 8,9% p=0,003 vs 26,67 ± 7,6%, p=0,315. CONCLUSÃO: O estudo sugere que a administração de levosimendana, mas não de dobutamina, encurta a duração do QRS no ECG de superfície, possivelmente por causar uma contração coletiva nas fibras do músculo do ventrículo esquerdo. A base molecular desse efeito ainda precisa ser esclarecida.FUNDAMENTO: La levosimendana es un nuevo agente inotrópico que aumenta la contractibilidad cardíaca sin aumentar la captación celular de

  15. Perioperative smoking cessation in vascular surgery

    DEFF Research Database (Denmark)

    Kehlet, M.; Heesemann, Sabine; Tonnesen, H.

    2015-01-01

    Background: The effect of intensive smoking cessation programs on postoperative complications has never before been assessed in soft tissue surgery when smoking cessation is initiated on the day of surgery. Methods: A single-blinded randomized clinical trial conducted at two vascular surgery...... departments in Denmark. The intervention group was offered the Gold Standard Program (GSP) for smoking cessation intervention. The control group was offered the departments' standard care. Inclusion criteria were patients with planned open peripheral vascular surgery and who were daily smokers. According...

  16. Genealogy of training in vascular neurosurgery.

    Science.gov (United States)

    Chowdhry, Shakeel A; Spetzler, Robert F

    2014-02-01

    Remarkable advances and changes in the landscape of neurovascular disease have occurred recently. Concurrently, a paradigm shift in training and resident education is underway. This crossroad of unique opportunities and pressures necessitates creative change in the training of future vascular neurosurgeons to allow incorporation of surgical advances, new technology, and supplementary treatment modalities in a setting of reduced work hours and increased public scrutiny. This article discusses the changing landscape in neurovascular disease treatment, followed by the recent changes in resident training, and concludes with our view of the future of training in vascular neurosurgery.

  17. Vascularized Composite Allografts: Procurement, Allocation, and Implementation.

    Science.gov (United States)

    Rahmel, Axel

    Vascularized composite allotransplantation is a continuously evolving area of modern transplant medicine. Recently, vascularized composite allografts (VCAs) have been formally classified as 'organs'. In this review, key aspects of VCA procurement are discussed, with a special focus on interaction with the procurement of classical solid organs. In addition, options for a matching and allocation system that ensures VCA donor organs are allocated to the best-suited recipients are looked at. Finally, the different steps needed to promote VCA transplantation in society in general and in the medical community in particular are highlighted.

  18. Early vascular plants in the Czech Republic

    OpenAIRE

    Uhlířová, Monika

    2017-01-01

    Vascular plants are characterized as a group of plants, which are already fully adapted to live on the land. Their evolution is a result of a set of adaptations that have required the necessary changes at anatomical and morphological level. Some evidences about the rise of vascular plants appear in the fossil record from the Middle Ordovician in the form of spores and later also from the Early Silurian in the form of megafossils. The aim of the thesis is to briefly describe and discuss the mo...

  19. Radiological study of cerebro-vascular accidents

    International Nuclear Information System (INIS)

    Misri, H.T.; Kabawe, Bassam

    1991-01-01

    The role of computerized tomography scanner in studying the cerebro-vascular accidents has been discussed. One hundred fifty patients with cerebro-vascular accidents were studied at Aleppo University Hospital between 1989-1990. Clinical history and physical examination were recorded, as well as, computerized tomography scanning in all cases without using the contrast media mostly. Relationship between the density of the lesion (inforctionor hemorrhage) and the time has been found. This relationship can help in forensic medicine. (author). 29 refs., 5 tabs., 2 figs

  20. Angiogenesis and vascular targeting: Relevance for hyperthermia

    DEFF Research Database (Denmark)

    Horsman, Michael R

    2008-01-01

    The creation of a functional blood supply from the normal tissue vasculature via the process of angiogenesis is critical for the continued growth and development of solid tumours. This importance has led to the concept of targeting the tumour vasculature as a therapeutic strategy, and two major...... types of vascular targeting agents (VTAs) have developed; those that inhibit the angiogenic process-angiogenesis inhibiting agents (AIAs)-and those that specifically damage the already established neovasculature-vascular disrupting agents (VDAs). The tumour vasculature also plays a critical role...

  1. Age related changes in tumor vascularity

    International Nuclear Information System (INIS)

    Loerelius, L.E.; Stridbeck, H.

    1984-01-01

    VX 2 tumors in the rabbit hind leg were investigated at one, two and three weeks of age. Angiograms were compared with vascular casts. The tumors grew rapidly the first two weeks of age. Large variations in vascularity were noted between tumors of different ages. With increasing age arteriovenous shunts at the tumor periphery and areas of avascularity of necrosis in the tumor center increased in size. Possible reasons for tumor necrosis are increased tissue pressure, anoxia caused by arteriovenous shunts and elevation in venous pressure. The natural history of the VX 2 tumor must be considered in every experimental study of the effect of any treatment. (orig.)

  2. Improving Technology for Vascular Imaging

    Science.gov (United States)

    Rana, Raman

    Neuro-endovascular image guided interventions (Neuro-EIGIs) is a minimally invasive procedure that require micro catheters and endovascular devices be inserted into the vasculature via an incision near the femoral artery and guided under low dose fluoroscopy to the vasculature of the head and neck. However, the endovascular devices used for the purpose are of very small size (stents are of the order of 50mum to 100mum) and the success of these EIGIs depends a lot on the accurate placement of these devices. In order to accurately place these devices inside the patient, the interventionalist should be able to see them clearly. Hence, high resolution capabilities are of immense importance in neuro-EIGIs. The high-resolution detectors, MAF-CCD and MAF-CMOS, at the Toshiba Stroke and Vascular Research Center at the University at Buffalo are capable of presenting improved images for better patient care. Focal spot of an x-ray tube plays an important role in performance of these high resolution detectors. The finite size of the focal spot results into the blurriness around the edges of the image of the object resulting in reduced spatial resolution. Hence, knowledge of accurate size of the focal spot of the x-ray tube is very essential for the evaluation of the total system performance. Importance of magnification and image detector blur deconvolution was demonstrated to carry out the more accurate measurement of x-ray focal spot using a pinhole camera. A 30 micron pinhole was used to obtain the focal spot images using flat panel detector (FPD) and different source to image distances (SIDs) were used to achieve different magnifications (3.16, 2.66 and 2.16). These focal spot images were deconvolved with a 2-D modulation transfer function (MTF), obtained using noise response (NR) method, to remove the detector blur present in the images. Using these corrected images, the accurate size of all the three focal spots were obtained and it was also established that effect of

  3. Engineering the mechanical and biological properties of nanofibrous vascular grafts for in situ vascular tissue engineering.

    Science.gov (United States)

    Henry, Jeffrey J D; Yu, Jian; Wang, Aijun; Lee, Randall; Fang, Jun; Li, Song

    2017-08-17

    Synthetic small diameter vascular grafts have a high failure rate, and endothelialization is critical for preventing thrombosis and graft occlusion. A promising approach is in situ tissue engineering, whereby an acellular scaffold is implanted and provides stimulatory cues to guide the in situ remodeling into a functional blood vessel. An ideal scaffold should have sufficient binding sites for biomolecule immobilization and a mechanical property similar to native tissue. Here we developed a novel method to blend low molecular weight (LMW) elastic polymer during electrospinning process to increase conjugation sites and to improve the mechanical property of vascular grafts. LMW elastic polymer improved the elasticity of the scaffolds, and significantly increased the amount of heparin conjugated to the micro/nanofibrous scaffolds, which in turn increased the loading capacity of vascular endothelial growth factor (VEGF) and prolonged the release of VEGF. Vascular grafts were implanted into the carotid artery of rats to evaluate the in vivo performance. VEGF treatment significantly enhanced endothelium formation and the overall patency of vascular grafts. Heparin coating also increased cell infiltration into the electrospun grafts, thus increasing the production of collagen and elastin within the graft wall. This work demonstrates that LMW elastic polymer blending is an approach to engineer the mechanical and biological property of micro/nanofibrous vascular grafts for in situ vascular tissue engineering.

  4. Vascular plugs - A key companion to Interventionists - 'Just Plug it'.

    Science.gov (United States)

    Ramakrishnan, Sivasubramanian

    2015-01-01

    Vascular plugs are ideally suited to close extra-cardiac, high flowing vascular communications. The family of vascular plugs has expanded. Vascular plugs in general have a lower profile and the newer variants can be delivered even through a diagnostic catheter. These features make them versatile and easy to use. The Amplatzer vascular plugs are also used for closing intracardiac defects including coronary arterio-venous fistula and paravalvular leakage in an off-label fashion. In this review, the features of currently available vascular plugs are reviewed along with tips and tricks of using them in the cardiac catheterization laboratory. Copyright © 2015. Published by Elsevier B.V.

  5. Oscillation of Angiogenesis and Vascular Dropout in Progressive Human Vascular Disease. [Vascular Pattern as Useful Read-Out of Complex Molecular Signaling

    Science.gov (United States)

    Parsons-Wingerter, Patricia

    2010-01-01

    When analyzed by VESsel GENeration Analysis (VESGEN) software, vascular patterns provide useful integrative read-outs of complex, interacting molecular signaling pathways. Using VESGEN, we recently discovered and published our innovative, surprising findings that angiogenesis oscillated with vascular dropout throughout progression of diabetic retinopathy, a blinding vascular disease. Our findings provide a potential paradigm shift in the current prevailing view on progression and treatment of this disease, and a new early-stage window of regenerative therapeutic opportunities. The findings also suggest that angiogenesis may oscillate with vascular disease in a homeostatic-like manner during early stages of other inflammatory progressive diseases such as cancer and coronary vascular disease.

  6. Evolución del deterioro cognitivo y el nivel de dependencia en pacientes mayores de 65 años ingresados en un hospital de agudos: relación con las variables sociodemográficas

    Directory of Open Access Journals (Sweden)

    Mª José Calero-García

    2014-04-01

    Full Text Available El primer objetivo de este trabajo es establecer y estudiar la evolución de las etapas de deterioro cognitivo y los niveles de dependencia en pacientes mayores de 65 años, ingresados en un hospital de agudos, así como la relación entre estos dos factores y las diferentes variables demográficas. Los resultados muestran que el nivel de dependencia experimenta una caída repentina en el momento de la admisión, que evoluciona hacia una recuperación leve en el momento del alta, continuando esta recuperación en el domicilio posteriormente al alta, pero sin llegar a los niveles independentistas antes de la admisión. Además, se encontraron diferencias significativas en cuanto a edad, estado civil y nivel educativo. De una manera general, nuestros resultados proporcionan evidencia sobre el hecho de que las personas especialmente propensas al aumento de la dependencia funcional y el deterioro cognitivo severo durante el ingreso hospitalario son los ancianos hombres, mayores de 80 años de edad, sin estudios y viudos.

  7. O polimorfismo A1166C do receptor tipo 1 da angiotensina II no infarto agudo do miocárdio The A1166C polymorphism of the angiotensin II type-1 receptor in acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Messias Antônio de Araújo

    2004-11-01

    Full Text Available RESUMO OBJETIVO:Avaliar a associação do polimorfismo A1166C do gene do receptor AT1 da angiotensina II (AT1R com o infarto agudo do miocárdio e a severidade da doença arterial coronariana. MÉTODOS: Estudo prospectivo, transversal de 110 pacientes com infarto agudo do miocárdio submetidos à angiografia coronariana com lesão significante (> 50% avaliada por três critérios de severidade: número de vasos lesados, morfologia da placa aterosclerótica e escore de risco coronariano. Sem lesões coronarianas 104 indivíduos controles. O polimorfismo A1166C do gene do AT1R foi determinado pela reação em cadeia da polimerase no DNA dos leucócitos do sangue periférico. Os fatores de risco coronariano clássicos foram analisados em todos os indivíduos. RESULTADOS: Na estratificação dos genótipos em relação aos fatores de risco apenas o tabagismo teve predominância nos heterozigotos AC (p = 0,02. A freqüência dos genótipos nos pacientes infartados foi de AA = 54,5%; AC = 35,5% e CC = 10%, sendo similar e não significativa em relação aos controles (p = 0,83. Não houve aumento do risco de infarto agudo do miocárdio nas comparações dos genótipos CC vs AA (OR = 1,35; IC-95% = 0,50 - 3,59, AC vs AA (OR = 1,03; IC-95% = 0,58 - 1,84 e AA+AC vs AA (OR = 1,33; IC-95% = 0,51 - 3,45. Nenhum dos critérios de severidade teve associação significativa com os genótipos. CONCLUSÃO: Os nossos resultados indicam não haver associação do polimorfismo A1166C do AT1R com o infarto agudo do miocárdio e nem com a severidade da doença arterial coronariana segundo nossos resultados.OBJECTIVE: To assess the association of the A1166C polymorphism of the angiotensin II type-1 receptor (AT1R gene with acute myocardial infarction and also with the severity of coronary artery disease. METHODS: A prospective, cross-sectional study was carried out with 110 patients with acute myocardial infarction, who, on coronary angiography, had significant

  8. Infarto agudo del miocardio sin elevación del segmento T: Consideraciones fisiopatológicas y clínicas Heart attack without an elevation of the T segment: Clinical and pathophysiological

    Directory of Open Access Journals (Sweden)

    Maikel Rodulfo García

    2010-09-01

    Full Text Available Se revisaron numerosos documentos (impresos y electrónicos sobre afecciones cardiovasculares, particularmente acerca del infarto agudo del miocardio sin elevación del segmento T, teniendo en cuenta que la mortalidad hospitalaria es menor cuando se produce un síndrome coronario con esa característica. Para actualizar el tema se valoraron diversos aspectos relacionados con concepto, clasificación, fisiopatología, diagnóstico, cuadro clínico, exámenes complementarios y factores de riesgo, puesto que las enfermedades del corazón son actualmente la principal causa de muerte en naciones industrializadas y se espera que también lo sean en los países en vías de desarrollo para el 2020, entre ellos Cuba.Several documents (printed and electronic about cardiovascular diseases were reviewed, particularly heart attack without an elevation of the T-segment, taking into account that the hospital mortality is lower when a coronary syndrome with that characteristic occurs. To update the topic several aspects related to concept, classification, pathophysiology, diagnosis, clinical pattern, laboratory tests and risk factors were valued since heart diseases are actually the main cause of death in industrialized nations and it is expected that they will also be the same cause of death in developing countries for 2020, among them, Cuba.

  9. Análise das barreiras à utilização de trombolíticos em casos de acidente vascular cerebral isquêmico em um hospital privado do Rio de Janeiro, Brasil

    Directory of Open Access Journals (Sweden)

    Luiz Henrique de Oliveira Fonseca

    2013-12-01

    Full Text Available O acidente vascular cerebral isquêmico (AVCi é uma importante causa de sequela e morte. A correta utilização do trombolítico enfrenta várias barreiras. O objetivo foi discutir as barreiras à terapia trombolítica em pacientes que chegam, com sintomas de AVCi agudo, à emergência de um hospital privado do Rio de Janeiro, Brasil. Coorte retrospectiva de pacientes entre 2009 e 2011. Foram admitidos 257 pacientes com suspeita de AVCi. Dos pacientes com diagnóstico confirmado (156, 11,5% (18 foram trombolisados. Dos 30 pacientes com diagnóstico de AVCi, dentro da janela terapêutica e com NIHSS na faixa para trombólise, 20 não foram trombolisados, 9 por barreiras administrativas (45%. Neste trabalho o percentual de trombólise foi superior ao observado nos Estados Unidos, mas barreiras impediram o tratamento de 45% dos pacientes com indicação à trombólise. Imagina-se que na rede pública brasileira a situação seja ainda mais desfavorável.

  10. Vascular risk factors, cognitve decline, and dementia

    Directory of Open Access Journals (Sweden)

    E Duron

    2008-04-01

    Full Text Available E Duron, Olivier HanonBroca Hospital, Paris, FranceAbstract: Dementia is one of the most important neurological disorders in the elderly. Aging is associated with a large increase in the prevalence and incidence of degenerative (Alzheimer’s disease and vascular dementia, leading to a devastating loss of autonomy. In view of the increasing longevity of populations worldwide, prevention of dementia has turned into a major public health challenge. In the past decade, several vascular risk factors have been found to be associated with vascular dementia but also Alzheimer’s disease. Some longitudinal studies, have found significant associations between hypertension, diabetus mellitus, and metabolic syndrome, assessed at middle age, and dementia. Studies assessing the link between hypercholesterolemia, atrial fibrillation, smoking, and dementia have given more conflicting results. Furthermore, some studies have highlighted the possible protective effect of antihypertensive therapy on cognition and some trials are evaluating the effects of statins and treatments for insulin resistance. Vascular risk factors and their treatments are a promising avenue of research for prevention of dementia, and further long-term, placebo-controlled, randomized studies, need to be performed.Keywords: dementia, hypertension, diabetus mellitus, hypercholesterolemia, metabolic syndrome

  11. Vascular anatomy in angiography for magnetic resonance

    International Nuclear Information System (INIS)

    Charry Lopez, Marco Luciano; Rivera Gomez, Juan Enrique

    1998-01-01

    A review of basic anatomical concepts and main variants, as well as some anatomical anomalies of the central nervous system vascularity, these concepts are considered essential for the interpretation of magnetic resonance angiography with time-of-flight (TOF) and phase-contrast (PC) methods

  12. CT imaging of cervical spinal vascular malformation

    International Nuclear Information System (INIS)

    Ueda, Takashi; Iwamoto, Munehisa; Miyamoto, Etsuo; Kuriyama, Tsuyoshi; Hayama, Tsuneto

    1982-01-01

    The patient had a history of the onset of motor paralysis of the right upper and lower extremities. Eight years later, numbness of the right upper extremity and a severe neck pain developed, and transverse paralysis of the lower extremities appeared in about 10 hours. CT demonstrated the presence of spinal vascular abnormality. Angiography suggested arteriovenous malformation of glomus type. (Chiba, N.)

  13. NEURO-VASCULAR INJURIES ASSOCIATED WITH LIMB ...

    African Journals Online (AJOL)

    hi-tech

    2000-12-01

    Dec 1, 2000 ... Subjects: Forty three patients with bone fractures associated with vascular and peripheral nerve injury seen at the Emergency Room of Assir Central Hospital from 1990 to 1999. There were 39 males and four females. Thirty five of these patients (81.4%) were Saudi nationals and the rest were non-Saudi.

  14. B vitamins influence vascular cognitive impairment

    Science.gov (United States)

    As the number of elderly in the USA and globally continues to increase, age-related neurological disorders, such as Alzheimer's disease and vascular dementia, are a growing concern. The loss of memory, emotional changes, and impairments in general cognitive functioning frequently result in social is...

  15. Quality Estimation for Vascular Pattern Recognition

    DEFF Research Database (Denmark)

    Hartung, Daniel; Martin, Sophie; Busch, Christoph

    2011-01-01

    The quality of captured samples is a critical aspect in biometric systems. In this paper we present a quality estimation algorithm for vascular images, which uses global and local features based on a Grey Level Co-Occurrence Matrix (GLCM) and optionally available metadata. An evaluation of the al...

  16. Self-management of vascular risk factors

    NARCIS (Netherlands)

    Sol-de Rijk, B.G.M.

    2009-01-01

    Summary The aim of this thesis was to provide insight into the potential of a self-management approach in treatment of vascular risk factors and to develop a self-management intervention. Furthermore to examine if this intervention, based on self-efficacy promoting theory, is effective in reducing

  17. Human genetics of diabetic vascular complications

    Indian Academy of Sciences (India)

    Diabetic vascular complications (DVC) affecting several important organ systems of human body such as the cardiovascular system constitute a major public health problem. There is evidence demonstrating that genetic factors contribute to the risk of DVC genetic variants, structural variants, and epigenetic changes play ...

  18. CT imaging of cervical spinal vascular malformation

    Energy Technology Data Exchange (ETDEWEB)

    Ueda, Takashi; Iwamoto, Munehisa; Miyamoto, Etsuo; Kuriyama, Tsuyoshi; Hayama, Tsuneto [Wakayama Red Cross Hospital, Wakayama (Japan)

    1982-05-01

    The patient had a history of the onset of motor paralysis of the right upper and lower extremities. Eight years later, numbness of the right upper extremity and a severe neck pain developed, and transverse paralysis of the lower extremities appeared in about 10 hours. CT demonstrated the presence of spinal vascular abnormality. Angiography suggested arteriovenous malformation of glomus type.

  19. LASER TREATMENT OF BENIGN CUTANEOUS VASCULAR LESIONS

    Directory of Open Access Journals (Sweden)

    Uroš Ahčan

    2004-07-01

    Full Text Available Background. Congenital and acquired vascular lesions of the skin and subcutis are a common health problem from aesthetic and also from psycho-social point of view. However, recent advances in laser technology have enabled an efficient and safe treatment. This study presents our experience with treatment of cutaneous vascular lesions using modern laser systems. Most common benign cutaneous vascular lesions are described.Patients and methods. In years 2002 and 2003, 109 patients, 4 to 80 (mean 39 years old, Fitzpatrick skin type 1–4, with 210 benign cutaneous vascular lesions were treated using the Dualis VP® laser system (Fotona, Slovenia which incorporates the KTP and Nd:YAG lasers. Vascular lesions in the upper layers of the skin with diameter up to 1 mm were treated with the KTP laser (wavelength 532 nm. For larger vessels in deeper layer we used the Nd:YAG laser (wavelength 1064 nm. Patients graded the pain during treatment on a scale of 1–10. Clinical outcomes were evaluated 1–3 months after the last treatment: according to the percentage of clearance of the lesion compared to the adjacent normal skin and for the presence of adverse effects. According to these criteria each lesion was assigned a score: poor (0–25%, fair (26–50%, good (51–75%, excellent (76–100%.Results. Immediate response after application of a laser beam with proper characteristics was whitish-grey discoloration of treated area. Treatment results after 1–3 months were excellent in 48.1%, good 40.9%, fair in 8.6% and poor in 2.4%. Patients without prior anaesthesia graded pain during treatment from 1 to 8 (mean 4.0 and patients with EMLA® anaesthesia from 1 to 6 (mean 2.6. Side effects were frequent but minimal and transient. Erythema disappeared in several days after treatment while crusting persisted for 14 days. 3 permanent hyperpigmentations, 2 permanent hypopigmentations, 2 hypertrophic scars and 1 beam sized atrophic scar were detected at last follow

  20. Vascular Contributions to Cognitive Impairment and Dementia

    Science.gov (United States)

    Gorelick, Philip B.; Scuteri, Angelo; Black, Sandra E.; DeCarli, Charles; Greenberg, Steven M.; Iadecola, Costantino; Launer, Lenore J.; Laurent, Stephane; Lopez, Oscar L.; Nyenhuis, David; Petersen, Ronald C.; Schneider, Julie A.; Tzourio, Christophe; Arnett, Donna K.; Bennett, David A.; Chui, Helena C.; Higashida, Randall T.; Lindquist, Ruth; Nilsson, Peter M.; Roman, Gustavo C.; Sellke, Frank W.; Seshadri, Sudha

    2013-01-01

    Background and Purpose This scientific statement provides an overview of the evidence on vascular contributions to cognitive impairment and dementia. Vascular contributions to cognitive impairment and dementia of later life are common. Definitions of vascular cognitive impairment (VCI), neuropathology, basic science and pathophysiological aspects, role of neuroimaging and vascular and other associated risk factors, and potential opportunities for prevention and treatment are reviewed. This statement serves as an overall guide for practitioners to gain a better understanding of VCI and dementia, prevention, and treatment. Methods Writing group members were nominated by the writing group co-chairs on the basis of their previous work in relevant topic areas and were approved by the American Heart Association Stroke Council Scientific Statement Oversight Committee, the Council on Epidemiology and Prevention, and the Manuscript Oversight Committee. The writing group used systematic literature reviews (primarily covering publications from 1990 to May 1, 2010), previously published guidelines, personal files, and expert opinion to summarize existing evidence, indicate gaps in current knowledge, and, when appropriate, formulate recommendations using standard American Heart Association criteria. All members of the writing group had the opportunity to comment on the recommendations and approved the final version of this document. After peer review by the American Heart Association, as well as review by the Stroke Council leadership, Council on Epidemiology and Prevention Council, and Scientific Statements Oversight Committee, the statement was approved by the American Heart Association Science Advisory and Coordinating Committee. Results The construct of VCI has been introduced to capture the entire spectrum of cognitive disorders associated with all forms of cerebral vascular brain injury—not solely stroke—ranging from mild cognitive impairment through fully developed

  1. Coexistence of pheochromocytoma with uncommon vascular lesions

    Directory of Open Access Journals (Sweden)

    Sunil Kumar Kota

    2012-01-01

    Full Text Available Background: Pheochromocytoma/paragangliomas have been described to be associated with rare vascular abnormalities like renal artery stenosis. Coexistence of physiologically significant renal artery lesions is a compounding factor that alters management and prognosis of pheochromocytoma patients. Apart from individual case reports, data on such association in Indian population is not available. The aim of this study is to find the nature and prevalence of associated vascular abnormalities. Materials and Methods: From 1990 to 2010, a total of 50 patients were diagnosed with pheochromocytoma/paragangliomas. Hospital charts of these patients were reviewed retrospectively to identify those with unusual vascular abnormalities. Available literature was also reviewed. Results: Of the 50 patients with pheochromocytoma, 7 (14% had coexisting vascular lesions including renal artery stenosis in 4, aortoarteritis in 1, aortic aneurysm in 1 and inferior vena cava thrombosis in 1. Pheochromocytoma was adrenal in 42 and extra adrenal in 8. Laparoscopic adrenalectomy was done in the patients. One patient with renal artery stenosis due to intimal fibrosis was subjected to percutaneous balloon angioplasty; the other three improved after adrenalectomy and lysis of fibrous adhesive bands. The patient with aortoarteritos was treated with oral steroids. Inferior vena cava thrombosis was reversed with anticoagulants. The patient with abdominal aortic aneurysm was advised for annual follow-up on account of its size of 4.5 cm and asymptomatic presentation. Conclusion: There are multiple mechanisms that can lead to renal artery stenosis and other vascular abnormalities in a case of pheochromocytoma. A high index of suspicion is necessary to enable both entities to be diagnosed preoperatively and allow proper planning of surgical therapy. Incomplete diagnosis may lead to persistent hypertension postoperatively in a case of associated renal artery stenosis.

  2. The making of indigenous vascular prosthesis

    Directory of Open Access Journals (Sweden)

    Madathipat Unnikrishnan

    2016-01-01

    Full Text Available Background & objectives: Vascular illnesses are on the rise in India, due to increase in lifestyle diseases and demographic transition, requiring intervention to save life, organ or limbs using vascular prosthesis. The aim of this study was to develop indigenous large diameter vascular graft for treatment of patients with vascular pathologies. Methods: The South India Textile Research Association, at Coimbatore, Tamil Nadu, India, developed seamless woven polyester (Polyethylene terephthalate graft at its research wing. Further characterization and testing followed by clinical trials were conducted at Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India. Fifteen in vivo experiments were carried out in 1992-1994 in pigs as animal model. Controlled (phase I clinical trial in ten patients was performed along with control graft. Thereafter, phase II trial involved 22 patients who underwent multi-centre clinical trial in four centres across India. Results: Laboratory testing showed that polyester graft was non-toxic, non-leeching and non-haemolytic with preserved long-term quality, further confirming in pigs by implanting in thoracic aorta, comparable to control Dacron grafts. Perigraft incorporation and smooth neointima formation which are prime features of excellent healing characteristics, were noted at explantation at planned intervals. Subsequently in the phase I and II clinical trials, all patients had excellent recovery without mortality or device-related adverse events. Patients receiving the test graft were followed up for 10 and 5 years, respectively. Serial clinical, duplex scans and CT angiograms performed periodically confirmed excellent graft performance. Interpretation & conclusions: Indigenously developed Chitra vascular graft was comparable to commercially available Dacron graft, ready for clinical use at affordable cost to patients as against costly imported grafts.

  3. A biodegradable vascularizing membrane: a feasibility study.

    Science.gov (United States)

    Kaushiva, Anchal; Turzhitsky, Vladimir M; Darmoc, Marissa; Backman, Vadim; Ameer, Guillermo A

    2007-09-01

    Regenerative medicine and in vivo biosensor applications require the formation of mature vascular networks for long-term success. This study investigated whether biodegradable porous membranes could induce the formation of a vascularized fibrous capsule and, if so, the effect of degradation kinetics on neovascularization. Poly(l-lactic acid) (PLLA) and poly(dl-lactic-co-glycolic) acid (PLGA) membranes were created by a solvent casting/salt leaching method. Specifically, PLLA, PLGA 75:25 and PLGA 50:50 polymers were used to vary degradation kinetics. The membranes were designed to have an average 60mum pore diameter, as this pore size has been shown to be optimal for inducing blood vessel formation around nondegradable polymer materials. Membrane samples were imaged by scanning electron microscopy at several time points during in vitro degradation to assess any changes in pore structure. The in vivo performance of the membranes was assessed in Sprague-Dawley rats by measuring vascularization within the fibrous capsule that forms adjacent to implants. The vascular density within 100microm of the membranes was compared with that seen in normal tissue, and to that surrounding the commercially available vascularizing membrane TheraCyte. The hemoglobin content of tissue containing the membranes was measured by four-dimensional elastic light scattering as a novel method to assess tissue perfusion. Results from this study show that slow-degrading membranes induce greater amounts of neovascularization and a thinner fibrous capsule relative to fast degrading membranes. These results may be due both to an initially increased number of macrophages surrounding the slower degrading membranes and to the maintenance of their initial pore structure.

  4. Advanced Maternal Age Worsens Postpartum Vascular Function

    Directory of Open Access Journals (Sweden)

    Jude S. Morton

    2017-06-01

    Full Text Available The age at which women experience their first pregnancy has increased throughout the decades. Pregnancy has an important influence on maternal short- and long-term cardiovascular outcomes. Pregnancy at an advanced maternal age increases maternal risk of gestational diabetes, preeclampsia, placenta previa and caesarian delivery; complications which predict worsened cardiovascular health in later years. Aging also independently increases the risk of cardiovascular disease; therefore, combined risk in women of advanced maternal age may lead to detrimental cardiovascular outcomes later in life. We hypothesized that pregnancy at an advanced maternal age would lead to postpartum vascular dysfunction. We used a reproductively aged rat model to investigate vascular function in never pregnant (virgin, previously pregnant (postpartum and previously mated but never delivered (nulliparous rats at approximately 13.5 months of age (3 months postpartum or equivalent. Nulliparous rats, in which pregnancy was spontaneously lost, demonstrated significantly reduced aortic relaxation responses (methylcholine [MCh] Emax: 54.2 ± 12.6% vs. virgin and postpartum rats (MCh Emax: 84.8 ± 3.5% and 84.7 ± 3.2% respectively; suggesting pregnancy loss causes a worsened vascular pathology. Oxidized LDL reduced relaxation to MCh in aorta from virgin and postpartum, but not nulliparous rats, with an increased contribution of the LOX-1 receptor in the postpartum group. Further, in mesenteric arteries from postpartum rats, endothelium-derived hyperpolarization (EDH-mediated vasodilation was reduced and a constrictive prostaglandin effect was apparent. In conclusion, aged postpartum rats exhibited vascular dysfunction, while rats which had pregnancy loss demonstrated a distinct vascular pathology. These data demonstrate mechanisms which may lead to worsened outcomes at an advanced maternal age; including early pregnancy loss and later life cardiovascular dysfunction.

  5. Endovascular Management of Vascular Injury during Transsphenoidal Surgery

    OpenAIRE

    Çinar, C.; Bozkaya, H.; Parildar, M.; Oran, I.

    2013-01-01

    Vascular injury is an unusual and serious complication of transsphenoidal surgery. We aimed to define the role of angiography and endovascular treatment in patients with vascular injuries occurring during transsphenoidal surgery.

  6. Vascular effects of a single high salt meal

    Directory of Open Access Journals (Sweden)

    Mohamed Abdel Kader Abdel Wahab

    2016-09-01

    Conclusion: High salt intake may acutely impair vascular function in different vascular beds independent of the increase of blood pressure. Plasma sodium increase may be one of the underlying mechanisms.

  7. Vascular surgery research in the Gulf Cooperation Council countries

    Directory of Open Access Journals (Sweden)

    Ali Jawas

    2014-04-01

    Conclusion: The quality and quantity of vascular surgery research in the GCC countries should be improved to answer important local questions related to vascular diseases. This needs better strategic planning and more collaboration between various institutions.

  8. Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease.

    Science.gov (United States)

    Khalil, Raouf A

    2013-12-15

    Cardiovascular disease (CVD) is less common in premenopausal women than men of the same age or postmenopausal women, suggesting vascular benefits of estrogen. Estrogen activates estrogen receptors ERα, ERβ and GPR30 in endothelium and vascular smooth muscle (VSM), which trigger downstream signaling pathways and lead to genomic and non-genomic vascular effects such as vasodilation, decreased VSM contraction and growth and reduced vascular remodeling. However, randomized clinical trials (RCTs), such as the Women's Health Initiative (WHI) and Heart and Estrogen/progestin Replacement Study (HERS), have shown little vascular benefits and even adverse events with menopausal hormone therapy (MHT), likely due to factors related to the MHT used, ER profile, and RCT design. Some MHT forms, dose, combinations or route of administration may have inadequate vascular effects. Age-related changes in ER amount, distribution, integrity and post-ER signaling could alter the vascular response to MHT. The subject's age, preexisting CVD, and hormone environment could also reduce the effects of MHT. Further evaluation of natural and synthetic estrogens, phytoestrogens, and selective estrogen-receptor modulators (SERMs), and the design of appropriate MHT combinations, dose, route and 'timing' could improve the effectiveness of conventional MHT and provide alternative therapies in the peri-menopausal period. Targeting ER using specific ER agonists, localized MHT delivery, and activation of specific post-ER signaling pathways could counter age-related changes in ER. Examination of the hormone environment and conditions associated with hormone imbalance such as polycystic ovary syndrome may reveal the causes of abnormal hormone-receptor interactions. Consideration of these factors in new RCTs such as the Kronos Early Estrogen Prevention Study (KEEPS) could enhance the vascular benefits of estrogen in postmenopausal CVD. Copyright © 2013 Elsevier Inc. All rights reserved.

  9. Cell sheet engineering using the stromal vascular fraction of adipose tissue as a vascularization strategy

    OpenAIRE

    Costa, M.; Cerqueira, Mariana Teixeira; Santos, T. C.; Marques, Belém Sampaio; Ludovico, Paula; Marques, A. P.; Pirraco, Rogério P.; Reis, R. L.

    2017-01-01

    Current vascularization strategies for Tissue Engineering constructs, in particular cell sheet-based, are limited by time-consuming and expensive endothelial cell isolation and/or by the complexity of using extrinsic growth factors. Herein, we propose an alternative strategy using angiogenic cell sheets (CS) obtained from the stromal vascular fraction (SVF) of adipose tissue that can be incorporated into more complex constructs. Cells from the SVF were cultured in normoxic and hypoxic conditi...

  10. Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia.

    Directory of Open Access Journals (Sweden)

    Sanjana Dayal

    Full Text Available There is an emerging consensus that hyperhomocysteinemia is an independent risk factor for cerebral vascular disease and that homocysteine-lowering therapy protects from ischemic stroke. However, the mechanisms by which hyperhomocysteinemia produces abnormalities of cerebral vascular structure and function remain largely undefined. Our objective in this study was to define the mechanistic role of superoxide in hyperhomocysteinemia-induced cerebral vascular dysfunction and hypertrophy. Unlike previous studies, our experimental design included a genetic approach to alter superoxide levels by using superoxide dismutase 1 (SOD1-deficient mice fed a high methionine/low folate diet to produce hyperhomocysteinemia. In wild-type mice, the hyperhomocysteinemic diet caused elevated superoxide levels and impaired responses to endothelium-dependent vasodilators in cerebral arterioles, and SOD1 deficiency compounded the severity of these effects. The cross-sectional area of the pial arteriolar wall was markedly increased in mice with SOD1 deficiency, and the hyperhomocysteinemic diet sensitized SOD1-deficient mice to this hypertrophic effect. Analysis of individual components of the vascular wall demonstrated a significant increase in the content of smooth muscle and elastin. We conclude that superoxide is a key driver of both cerebral vascular hypertrophy and vasomotor dysfunction in this model of dietary hyperhomocysteinemia. These findings provide insight into the mechanisms by which hyperhomocysteinemia promotes cerebral vascular disease and ischemic stroke.

  11. Using biplanar fluoroscopy to guide radiopaque vascular injections: a new method for vascular imaging.

    Directory of Open Access Journals (Sweden)

    Haley D O'Brien

    Full Text Available Studying vascular anatomy, especially in the context of relationships with hard tissues, is of great interest to biologists. Vascular studies have provided significant insight into physiology, function, phylogenetic relationships, and evolutionary patterns. Injection of resin or latex into the vascular system has been a standard technique for decades. There has been a recent surge in popularity of more modern methods, especially radiopaque latex vascular injection followed by CT scanning and digital "dissection." This technique best displays both blood vessels and bone, and allows injections to be performed on cadaveric specimens. Vascular injection is risky, however, because it is not a standardizable technique, as each specimen is variable with regard to injection pressure and timing. Moreover, it is not possible to view the perfusion of injection medium throughout the vascular system of interest. Both data and rare specimens can therefore be lost due to poor or excessive perfusion. Here, we use biplanar video fluoroscopy as a technique to guide craniovascular radiopaque latex injection. Cadaveric domestic pigs (Sus scrofa domestica and white-tailed deer (Odocoileus virginianus were injected with radiopaque latex under guidance of fluoroscopy. This method was found to enable adjustments, in real-time, to the rate, location, and pressure at which latex is injected in order to avoid data and specimen loss. In addition to visualizing the injection process, this technique can be used to determine flow patterns, and has facilitated the development of consistent markers for complete perfusion.

  12. Joint Global War on Terror (GWOT) Vascular Injury Study 2

    Science.gov (United States)

    2017-02-01

    acquired in Iraq and Afghanistan, Society for Trauma Nurse, 2-4 April 2014, poster presentation o Vascular discharge education and follow-up care...eventual quality of limb and psychological recovery or well-being. 15. SUBJECT TERMS extremity vascular injury, extremity, vascular injury, vascular... psychological recovery or well-being. Finally, this program aims to characterize and compare the physical and emotional burden in large cohorts of US

  13. Childhood Vascular Tumors Treatment (PDQ®)—Patient Version

    Science.gov (United States)

    Childhood vascular tumors form from cells that make blood vessels or lymph vessels. They can be benign (not cancer) or malignant (cancer). Get information about the symptoms, tests to diagnose, prognosis, and treatment of the most common type of vascular tumor, infantile hemangioma, and other vascular tumors in this expert-reviewed summary.

  14. The evolution of development of vascular cambia and secondary growth

    Science.gov (United States)

    Andrew Groover; Rachel Spicer

    2010-01-01

    Secondary growth from vascular cambia results in radial, woody growth of stems. The innovation of secondary vascular development during plant evolution allowed the production of novel plant forms ranging from massive forest trees to flexible, woody lianas. We present examples of the extensive phylogenetic variation in secondary vascular growth and discuss current...

  15. Development of the Australasian vascular surgical audit.

    Science.gov (United States)

    Bourke, Bernie M; Beiles, Charles Barry; Thomson, Ian A; Grigg, Michael J; Fitridge, Rob

    2012-01-01

    The purpose of this study was to describe the development of the Australasian Vascular Audit that was created to unify audit activities under the umbrella of the Australian and New Zealand Society for Vascular Surgery as a Web-based application. Constitutional change in late 2008 deemed participation in this audit compulsory for Society members. The Web-based application was developed and tested during 2009. Data for all open vascular surgery and for all endovascular procedures are collected at two points in the admission episode: at the time of operation and at discharge, and entered into the application. Data are analyzed to produce risk-adjusted outcomes. An algorithm has been developed to deal with outliers according to natural justice and to comply with the requirements of regulatory bodies. The Audit is protected by legislated privilege and is officially endorsed and indemnified by the Royal Australasian College of Surgeons. Confidentiality of surgeons and patients alike is ensured by a legally protected coding system and computer encryption system. Validation is by a verification process of 5% of members per year who are randomly selected. The application is completely funded by the Society. Data entry commenced on January 1, 2010. Over 40,000 vascular procedures were entered in the first year. The Audit application allows instantaneous on-line access to individual data and to deidentified group data and specific reports. It also allows real-time instantaneous production of log books for vascular trainees. The Audit has already gained recognition in the Australasian public arena during its first year of operation as an important benchmark of correct professional surgical behavior. Compliance has been extremely high in public hospitals but less so in private hospitals such that only 60% of members received a certificate of complete participation at the end of its first year of operation. An Internet-based compulsory audit of complete surgical practice is

  16. Management of vascular trauma from dog bites.

    Science.gov (United States)

    Akingba, A George; Robinson, Eric A; Jester, Andrea L; Rapp, Brian M; Tsai, Anthony; Motaganahalli, Raghu L; Dalsing, Michael C; Murphy, Michael P

    2013-11-01

    Vascular trauma from large-dog bites present with a combination of crush and lacerating injuries to the vessel, as well as significant adjacent soft tissue injury and a high potential for wound complications. This retrospective case series evaluates our 15 years of experience in managing this uncommonly seen injury into suggested treatment recommendations. From our database, 371 adult patients presented with dog bites between July 1997 and June 2012. Twenty (5.4%) of those patients had vascular injuries requiring surgical intervention. Patient demographics, anatomic location of injury, clinical presentation, imaging modality, method of repair, and complication rates were reviewed to assess efficacy in preserving limb function. Pediatric patients were managed at the regional children's hospital and, therefore, not included in this study. Among the 20 surgically treated vascular injuries, there were 13 arterial-only injuries, two venous-only injuries, and five combination arterial and venous injuries. Seventeen patients (85%) had upper extremity injuries; three patients had lower extremity injuries (15%). The axillobrachial artery was the most commonly injured single vessel (n = 9/20; 45%), followed by the radial artery (n = 4/20; 20%). Surgical repair of vascular injuries consisted of resection and primary anastomosis (four), interposition bypass of artery with autogenous vein (13), and ligation (two), with (one) being a combination of bypass and ligation. All patients had debridement of devitalized tissue combined with pulse lavage irrigation and perioperative antibiotics. Associated injuries requiring repair included muscle and skin (n = 10/20; 50%), bone (n = 1/20; 5%), nerve (n = 1/20; 5%), and combinations of the three (n = 5/20; 25%). Postoperative antibiotic therapy was administered for 14.7 ± 8.2 days in all 20 patients. Four patients (20%) developed postoperative wound infections, although this did not compromise their vascular repair. Of the patients

  17. Multinephron dynamics on the renal vascular network

    DEFF Research Database (Denmark)

    Marsh, Donald J; Wexler, Anthony S; Brazhe, Alexey

    2012-01-01

    Tubuloglomerular feedback (TGF) and the myogenic mechanism combine in each nephron to regulate blood flow and glomerular filtration rate. Both mechanisms are non-linear, generate self-sustained oscillations, and interact as their signals converge on arteriolar smooth muscle, forming a regulatory...... clusters. In-phase synchronization predominated among nephrons separated by 1 or 3 vascular nodes, and anti-phase synchronization for 5 or 7 nodes of separation. Nephron dynamics were irregular and contained low frequency fluctuations. Results are consistent with simultaneous blood flow measurements...... of both mechanisms in the regulatory ensemble, to examine the effects of network structure on nephron synchronization. Symmetry, as a property of a network, facilitates synchronization. Nephrons received blood from a symmetric electrically conductive vascular tree. Symmetry was created by using identical...

  18. Cocoa, Blood Pressure, and Vascular Function

    Science.gov (United States)

    Ludovici, Valeria; Barthelmes, Jens; Nägele, Matthias P.; Enseleit, Frank; Ferri, Claudio; Flammer, Andreas J.; Ruschitzka, Frank; Sudano, Isabella

    2017-01-01

    Cardiovascular disease (CVD) represents the most common cause of death worldwide. The consumption of natural polyphenol-rich foods, and cocoa in particular, has been related to a reduced risk of CVD, including coronary heart disease and stroke. Intervention studies strongly suggest that cocoa exerts a beneficial impact on cardiovascular health, through the reduction of blood pressure (BP), improvement of vascular function, modulation of lipid and glucose metabolism, and reduction of platelet aggregation. These potentially beneficial effects have been shown in healthy subjects as well as in patients with risk factors (arterial hypertension, diabetes, and smoking) or established CVD (coronary heart disease or heart failure). Several potential mechanisms are supposed to be responsible for the positive effect of cocoa; among them activation of nitric oxide (NO) synthase, increased bioavailability of NO as well as antioxidant, and anti-inflammatory properties. It is the aim of this review to summarize the findings of cocoa and chocolate on BP and vascular function. PMID:28824916

  19. Vascular anatomy of the spinal cord

    International Nuclear Information System (INIS)

    Thron, A.K.

    1988-01-01

    The book summarizes the anatomic guidelines of external blood supply to the spinal cord. The basic principles of arterial supply and venous drainage are illustrated by explicit schemes for quick orientation. In the first part of the book, systematic radiologic-anatomic investigations of the superficial and deep vessels of all segments of the spinal cord are introduced. The microvascular morphology is portrayed by numerous microradiographic sections in all three dimensions without overshadowing. The three-dimensional representation of the vascular architecture illustrates elementary outlines and details of arterial territories, anastomotic cross-linking as well as the capillary system, particularly the hitherto unknown structure of the medullary venous system with its functionally important anastomoses and varying regional structures. These often now radiologic-anatomic findings are discussed as to their functional and pathophysiologic impact and constitute the basic on which to improve one's understanding of vascular syndromes of the spinal cord

  20. Features and selection of vascular access devices.

    Science.gov (United States)

    Sansivero, Gail Egan

    2010-05-01

    To review venous anatomy and physiology, discuss assessment parameters before vascular access device (VAD) placement, and review VAD options. Journal articles, personal experience. A number of VAD options are available in clinical practice. Access planning should include comprehensive assessment, with attention to patient participation in the planning and selection process. Careful consideration should be given to long-term access needs and preservation of access sites. Oncology nurses are uniquely suited to perform a key role in VAD planning and placement. With knowledge of infusion therapy, anatomy and physiology, device options, and community resources, nurses can be key leaders in preserving vascular access and improving the safety and comfort of infusion therapy. Copyright 2010 Elsevier Inc. All rights reserved.

  1. Ample spectrum of vascular hepatic disease

    International Nuclear Information System (INIS)

    Camacho, Juan C; Marquez Adriana; Romero, Javier; Aguirre Diego

    2010-01-01

    Hepatic vascular diseases (HVD) are a broad spectrum of entities of low prevalence but with different clinical manifestations that may even lead to death. Its early detection and timely treatment may change the prognosis. Diagnostic imaging plays a key role and imaging findings may be typical. However, in most cases, radiologists must take into account a wide range of differential diagnosis. Computed tomography (CT) of the abdomen is one of the most useful tools for the diagnosis of HVD taking also into account the value of other imaging methods such as Doppler Ultrasound and Magnetic Resonance Imaging (MRI). HVD can be classified according to the compromised vascular structure and can be divided into venous, portal, arterial, sinusoidal and others disorders. The objective of this review is to describe the most common presentation HVD. The major imaging findings and differential diagnosis recognizing its correlation with the pathophysiological mechanisms.

  2. Cocoa, blood pressure, and vascular function.

    Science.gov (United States)

    Sudano, Isabella; Flammer, Andreas J; Roas, Susanne; Enseleit, Frank; Ruschitzka, Frank; Corti, Roberto; Noll, Georg

    2012-08-01

    The consumption of a high amount of fruits and vegetables was found to be associated with a lower risk of coronary heart disease and stroke. Epidemiologically, a similar relationship has been found with cocoa, a naturally polyphenol-rich food. Obviously, double blind randomized studies are difficult to perform with cocoa and chocolate, respectively. However, intervention studies strongly suggest that cocoa has several beneficial effects on cardiovascular health, including the lowering of blood pressure, the improvement of vascular function and glucose metabolism, and the reduction of platelet aggregation and adhesion. Several potential mechanisms through which cocoa might exert its positive effects have been proposed, among them activation of nitric oxide synthase, increased bioavailability of nitric oxide as well as antioxidant, and anti-inflammatory properties. It is the aim of this review to summarize the findings of cocoa and chocolate on blood pressure and vascular function.

  3. Vascularization of soft tissue engineering constructs

    DEFF Research Database (Denmark)

    Pimentel Carletto, Rodrigo

    nanotechnology-based paradigm for engineering vascularised liver tissue for transplantation”) and the Danish National Research Foundation and Villum Foundation’s Center for Intelligent Drug delivery and sensing Using microcontainers and Nanomechanics (Danish National Research Foundation (DNRF122).......Vascularization is recognized to be the biggest challenge for the fabrication of tissues and finally, organs in vitro. So far, several fabrication techniques have been proposed to create a perfusable vasculature within hydrogels, however, the vascularization and perfusion of hydrogels...... with mechanical properties in the range of soft tissues has not been fully achieved. My project focused on the fabrication and the active perfusion of hydrogel constructs with multi-dimensional vasculature and controlled mechanical properties targeting soft tissues. Specifically, the initial part of the research...

  4. Cocoa, Blood Pressure, and Vascular Function

    Directory of Open Access Journals (Sweden)

    Valeria Ludovici

    2017-08-01

    Full Text Available Cardiovascular disease (CVD represents the most common cause of death worldwide. The consumption of natural polyphenol-rich foods, and cocoa in particular, has been related to a reduced risk of CVD, including coronary heart disease and stroke. Intervention studies strongly suggest that cocoa exerts a beneficial impact on cardiovascular health, through the reduction of blood pressure (BP, improvement of vascular function, modulation of lipid and glucose metabolism, and reduction of platelet aggregation. These potentially beneficial effects have been shown in healthy subjects as well as in patients with risk factors (arterial hypertension, diabetes, and smoking or established CVD (coronary heart disease or heart failure. Several potential mechanisms are supposed to be responsible for the positive effect of cocoa; among them activation of nitric oxide (NO synthase, increased bioavailability of NO as well as antioxidant, and anti-inflammatory properties. It is the aim of this review to summarize the findings of cocoa and chocolate on BP and vascular function.

  5. Noninvasive studies of peripheral vascular disease

    International Nuclear Information System (INIS)

    Yao, J.S.T.

    1987-01-01

    Plethysmography probably is the oldest method for measuring blood flow. In this method, measurements are made of changes in volume of an organ or region of tissue. In the modern practice of vascular surgery, the use of plethysmography has been expanded to include detection of not only arterial occlusive disease but also carotid artery disease and venous problems. Several types of plethysmographs are now available for clinical use in the evaluation of arterial occlusions. These are volume, strain-gauge, and photoelectric plethysmographs. The water-filled volume recorder, popular in the early use of plethysmography, is now obsolete and has been replaced by the air-filled volume plethysmograph, notably, the pulse-volume recorder. For clinical application, the newer plethysmographs, such as the strain-gauge, photopletyhsmograph, and pulse-volume recorder, are now standard equipment in many vascular laboratories. They are discussed in this article

  6. Biophysical Regulation of Vascular Differentiation and Assembly

    CERN Document Server

    Gerecht, Sharon

    2011-01-01

    The ability to grow stem cells in the laboratory and to guide their maturation to functional cells allows us to study the underlying mechanisms that govern vasculature differentiation and assembly in health and disease. Accumulating evidence suggests that early stages of vascular growth are exquisitely tuned by biophysical cues from the microenvironment, yet the scientific understanding of such cellular environments is still in its infancy. Comprehending these processes sufficiently to manipulate them would pave the way to controlling blood vessel growth in therapeutic applications. This book assembles the works and views of experts from various disciplines to provide a unique perspective on how different aspects of its microenvironment regulate the differentiation and assembly of the vasculature. In particular, it describes recent efforts to exploit modern engineering techniques to study and manipulate various biophysical cues. Biophysical Regulation of Vascular Differentiation and Assembly provides an inter...

  7. Vascular endothelium receptors and transduction mechanisms

    CERN Document Server

    Gillis, C; Ryan, Una; Proceedings of the Advanced Studies Institute on "Vascular Endothelium: Receptors and Transduction Mechanisms"

    1989-01-01

    Beyond their obvious role of a barrier between blood and tissue, vascular endothelial cells are now firmly established as active and essential participants in a host of crucial physiological and pathophysiological functions. Probably the two most important factors responsible for promoting the current knowledge of endothelial functions are 1) observations in the late sixties-early seventies that many non-ventilatory properties of the lung could be attributed to the pulmonary endothelium and 2) the establishment, in the early and mid-seventies of procedures for routine culture of vascular endothelial cells. Many of these endothelial functions require the presence of receptors on the surface of the plasma membrane. There is now evidence for the existence among others of muscarinic, a-and /3-adrenergic, purine, insulin, histamine, bradykinin, lipoprotein, thrombin, paf, fibronectin, vitronectin, interleukin and albumin receptors. For some of these ligands, there is evidence only for the existence of endothelial ...

  8. Vascular anomalies of the cerebellopontine angle

    International Nuclear Information System (INIS)

    Papanagiotou, P.; Grunwald, I.Q.; Politi, M.; Struffert, T.; Ahlhelm, F.; Reith, W.

    2006-01-01

    Vascular anomalies of the cerebellopontine angle are rare compared to tumors in this area. Irritation of the trigeminal, facial, or vestibulocochlear nerve may cause trigeminal neuralgia, hemifacial spasm and vertigo, or tinnitus accordingly. Vessel loops in the cerebellopontine cisterns may cause compression at the root entry or exit zone of the cranial nerves V, VII, and VIII, a phenomenon which is called ''vascular loop syndrome.'' Megadolichobasilar artery and aneurysms of the vertebrobasilar system can also lead to dislocation and compression of the cranial nerves and brain stem. Three-dimensional CISS MR imaging and MR angiography are useful in the detection of neurovascular compression. Microvascular decompression is an effective surgical procedure in the management of compression syndromes of the cranial nerves V, VII, and VIII. (orig.) [de

  9. Molecular parallels between neural and vascular development.

    Science.gov (United States)

    Eichmann, Anne; Thomas, Jean-Léon

    2013-01-01

    The human central nervous system (CNS) features a network of ~400 miles of blood vessels that receives >20% of the body's cardiac output and uses most of its blood glucose. Many human diseases, including stroke, retinopathy, and cancer, are associated with the biology of CNS blood vessels. These vessels originate from extrinsic cell populations, including endothelial cells and pericytes that colonize the CNS and interact with glia and neurons to establish the blood-brain barrier and control cerebrovascular exchanges. Neurovascular interactions also play important roles in adult neurogenic niches, which harbor a unique population of neural stem cells that are intimately associated with blood vessels. We here review the cellular and molecular mechanisms required to establish the CNS vascular network, with a special focus on neurovascular interactions and the functions of vascular endothelial growth factors.

  10. Treatment of hemobilia by transcatheter vascular occlusion

    International Nuclear Information System (INIS)

    Vaughan, R.; Roesch, J.; Keller, F.S.; Antonovic, R.; Veterans Administration Medical Center, Portland, OR

    1984-01-01

    Four cases of hemobilia treated by transcatheter arterial occlusion are presented and reviewed with 30 similar cases reported in the literature. Transcatheter vascular occlusion successfully controlled hemorrhage in all 34 patients. No obvious liver parenchymal damage appeared in 26 patients; transient elevation of liver enzymes occurred in 6 patients (18%) including one in our series; two of the patients reviewed died of acute hepatic insufficiency following nonselective hepatic artery embolization. Hemobilia should be considered when gastrointestinal hemorrhage occurs after abdominal trauma, liver biopsy or other manipulative liver procedures. Hepatic angiography establishes the diagnosis and selective vascular occlusion is the treatment of choice for control of intractable or recurrent hemorrhage. Techniques and precautions for the diagnosis and transcatheter therapy of hemobilia are discussed. (orig.)

  11. Prediction of Major Vascular Events after Stroke

    DEFF Research Database (Denmark)

    Ovbiagele, Bruce; Goldstein, Larry B.; Amarenco, Pierre

    2014-01-01

    BACKGROUND: Identifying patients with recent stroke or transient ischemic attack (TIA) at high risk of major vascular events (MVEs; stroke, myocardial infarction, or vascular death) may help optimize the intensity of secondary preventive interventions. We evaluated the relationships between...... the baseline Framingham Coronary Risk Score (FCRS) and a novel risk prediction model and with the occurrence of MVEs after stroke or TIA in subjects enrolled in the Stroke Prevention by Aggressive Reduction in Cholesterol Level (SPARCL) trial. METHODS: Data from the 4731 subjects enrolled in the SPARCL study...... were analyzed. Hazard ratios (HRs) from Cox regression models were used to determine the risk of subsequent MVEs based on the FCRS predicting 20% or more 10-year coronary heart disease risk. The novel risk model was derived based on multivariable modeling with backward selection. Model discrimination...

  12. Vascular lesions of the vocal fold.

    Science.gov (United States)

    Gökcan, Kürşat Mustafa; Dursun, Gürsel

    2009-04-01

    The aim of the study was to present symptoms, laryngological findings, clinical course, management modalities, and consequences of vascular lesions of vocal fold. This study examined 162 patients, the majority professional voice users, with vascular lesions regarding their presenting symptoms, laryngological findings, clinical courses and treatment results. The most common complaint was sudden hoarseness with hemorrhagic polyp. Microlaryngoscopic surgery was performed in 108 cases and the main indication of surgery was the presence of vocal fold mass or development of vocal polyp during clinical course. Cold microsurgery was utilized for removal of vocal fold masses and feeding vessels cauterized using low power, pulsed CO(2) laser. Acoustic analysis of patients revealed a significant improvement of jitter, shimmer and harmonics/noise ratio values after treatment. Depending on our clinical findings, we propose treatment algorithm where voice rest and behavioral therapy is the integral part and indications of surgery are individualized for each patient.

  13. Protein Kinase C Inhibitors as Modulators of Vascular Function and Their Application in Vascular Disease

    Directory of Open Access Journals (Sweden)

    Raouf A. Khalil

    2013-03-01

    Full Text Available Blood pressure (BP is regulated by multiple neuronal, hormonal, renal and vascular control mechanisms. Changes in signaling mechanisms in the endothelium, vascular smooth muscle (VSM and extracellular matrix cause alterations in vascular tone and blood vessel remodeling and may lead to persistent increases in vascular resistance and hypertension (HTN. In VSM, activation of surface receptors by vasoconstrictor stimuli causes an increase in intracellular free Ca2+ concentration ([Ca2+]i, which forms a complex with calmodulin, activates myosin light chain (MLC kinase and leads to MLC phosphorylation, actin-myosin interaction and VSM contraction. Vasoconstrictor agonists could also increase the production of diacylglycerol which activates protein kinase C (PKC. PKC is a family of Ca2+-dependent and Ca2+-independent isozymes that have different distributions in various blood vessels, and undergo translocation from the cytosol to the plasma membrane, cytoskeleton or the nucleus during cell activation. In VSM, PKC translocation to the cell surface may trigger a cascade of biochemical events leading to activation of mitogen-activated protein kinase (MAPK and MAPK kinase (MEK, a pathway that ultimately increases the myofilament force sensitivity to [Ca2+]i, and enhances actin-myosin interaction and VSM contraction. PKC translocation to the nucleus may induce transactivation of various genes and promote VSM growth and proliferation. PKC could also affect endothelium-derived relaxing and contracting factors as well as matrix metalloproteinases (MMPs in the extracellular matrix further affecting vascular reactivity and remodeling. In addition to vasoactive factors, reactive oxygen species, inflammatory cytokines and other metabolic factors could affect PKC activity. Increased PKC expression and activity have been observed in vascular disease and in certain forms of experimental and human HTN. Targeting of vascular PKC using PKC inhibitors may function in

  14. Improved vascularization of planar membrane diffusion devices following continuous infusion of vascular endothelial growth factor.

    Science.gov (United States)

    Trivedi, N; Steil, G M; Colton, C K; Bonner-Weir, S; Weir, G C

    2000-01-01

    Improving blood vessel formation around an immunobarrier device should improve the survival of the encapsulated tissue. In the present study we investigated the formation of new blood vessels around a planar membrane diffusion device (the Baxter Theracyte System) undergoing a continuous infusion of vascular endothelial growth factor through the membranes and into the surrounding tissue. Each device (20 microl) had both an inner immunoisolation membrane and an outer vascularizing membrane. Human recombinant vascular endothelial growth factor-165 was infused at 100 ng/day (low dose: n = 6) and 500 ng/day (high dose: n = 7) for 10 days into devices implanted s.c. in Sprague-Dawley rats; noninfused devices transplanted for an identical period were used as controls (n = 5). Two days following the termination of VEGF infusion, devices were loaded with 20 microl of Lispro insulin (1 U/kg) and the kinetics of insulin release from the lumen of the device was assessed. Devices were then explanted and the number of blood vessels (capillary and noncapillary) was quantified using morphometry. High-dose vascular endothelial growth factor infusion resulted in two- to threefold more blood vessels around the device than that obtained with the noninfused devices and devices infused with low-dose vascular endothelial growth factor. This increase in the number of blood vessels was accompanied by a modest increase in insulin diffusion from the device in the high-dose vascular endothelial growth factor infusion group. We conclude that vascular endothelial growth factor can be used to improve blood vessel formation adjacent to planar membrane diffusion devices.

  15. NF1 Signal Transduction and Vascular Dysfunction

    Science.gov (United States)

    2015-05-01

    microenvironment that promotes much of the pathology associated with the disease . Moreover we hypothesize that a mechanistic consequence of the loss...obliteration of the normal red pulp architecture. In addition, we found significant peri-aveolar and peri-vascular inflammatory infiltrates in the lung...the mouse model of NF1 disease in the endothelium we proposed and have done experiments investigating the loss of endothelial NF1 in the adult

  16. Role of endovascular treatment in vascular injuries

    International Nuclear Information System (INIS)

    Tahir, M.M.; Haq, T.U.

    2012-01-01

    Objective: To evaluate retrospectively the results, complications and follow-up of patients after endovascular treatment of vascular injuries. Methods: Fifty transcatheter embolisation procedures (TCE) were performed in 46 patients between 1999 and 2008 at the Aga Khan University Hospital, Karachi. Injuries in 14 (30.4%) patients were due to road traffic accident; iatrogenic in 13 (28%); accidental in 6 (13%). Firearms, bomb blasts and earthquake contributed to injuries in 8(17%), 4(8.8%) and 1(2.2%) patients respectively. All patients underwent angiography and had evidence of either active haemorrhage, pseudo-aneurysm, abnormal vascularity or arteriovenous fistula. Follow-up ranged from 1 day to 6 years with mean of 10.5 months. Medical record files, lab results and imaging reports were utilised for the study. Procedure was declared as technically successful when there was cessation of extravasation, occlusion of fistula or exclusion of pseudo-aneurysm in the post-embolisation angiograms. Treatment was deemed clinically successful if there was resolution of the indication for which the procedure was done. Results: Transcatheter embolisation was technically successful in occluding vascular lesions in all 46 (100%) patients. Lesions recurred in 4 (9%) patients who underwent initially successful TCE. These patients were treated effectively with repeated TCE. Three patients died during the same hospital stay and 3 patients died after being discharged from the hospital. All these patients were treated successfully with TCE and had factors other then TCE contributing to their mortality. Conclusion: Transcatheter embolisation for vascular injuries was found to be a satisfactory procedure, with low morbidity and mortality rates. (author)

  17. Vascular access: the impact of ultrasonography

    Science.gov (United States)

    de Almeida, Carlos Eduardo Saldanha

    2016-01-01

    ABSTRACT Vascular punctures are often necessary in critically ill patients. They are secure, but not free of complications. Ultrasonography enhances safety of the procedure by decreasing puncture attempts, complications and costs. This study reviews important publications and the puncture technique using ultrasound, bringing part of the experience of the intensive care unit of the Hospital Israelita Albert Einstein, São Paulo (SP), Brazil, and discussing issues that should be considered in future studies. PMID:28076607

  18. Vascular Dysfunction in Horses with Endocrinopathic Laminitis.

    Directory of Open Access Journals (Sweden)

    Ruth A Morgan

    Full Text Available Endocrinopathic laminitis (EL is a vascular condition of the equine hoof resulting in severe lameness with both welfare and economic implications. EL occurs in association with equine metabolic syndrome and equine Cushing's disease. Vascular dysfunction, most commonly due to endothelial dysfunction, is associated with cardiovascular risk in people with metabolic syndrome and Cushing's syndrome. We tested the hypothesis that horses with EL have vascular, specifically endothelial, dysfunction. Healthy horses (n = 6 and horses with EL (n = 6 destined for euthanasia were recruited. We studied vessels from the hooves (laminar artery, laminar vein and the facial skin (facial skin arteries by small vessel wire myography. The response to vasoconstrictors phenylephrine (10-9-10-5M and 5-hydroxytryptamine (5HT; 10-9-10-5M and the vasodilator acetylcholine (10-9-10-5M was determined. In comparison with healthy controls, acetylcholine-induced relaxation was dramatically reduced in all intact vessels from horses with EL (% relaxation of healthy laminar arteries 323.5 ± 94.1% v EL 90.8 ± 4.4%, P = 0.01, laminar veins 129.4 ± 14.8% v EL 71.2 ± 4.1%, P = 0.005 and facial skin arteries 182.0 ± 40.7% v EL 91.4 ± 4.5%, P = 0.01. In addition, contractile responses to phenylephrine and 5HT were increased in intact laminar veins from horses with EL compared with healthy horses; these differences were endothelium-independent. Sensitivity to phenylephrine was reduced in intact laminar arteries (P = 0.006 and veins (P = 0.009 from horses with EL. Horses with EL exhibit significant vascular dysfunction in laminar vessels and in facial skin arteries. The systemic nature of the abnormalities suggest this dysfunction is associated with the underlying endocrinopathy and not local changes to the hoof.

  19. Role of vascular physiology in hyperthermia

    International Nuclear Information System (INIS)

    Song, C.W.

    1987-01-01

    The rate of blood supply to tumors significantly varies depending on the tumor type, site of tumor growth, and the stage of tumor growth. Even in the same tumor, blood flow is rather heterogeneous. The peripheral area of the tumors where the tissue pressure is relatively low is usually well perfused. Blood flow in the tumors may or may not be greater than that in the adjacent normal tissues. The response of newly formed tumor blood vessels to external stress, such as heat, it different from that in the normal tissues. Blood flow in the experimental rodent tumors initially increases up to twofold of control when heated at relatively low temperatures but tends to decrease when heated at temperatures above 42 0 -43 0 C. On the contrary, blood flow in the skin and muscle of rodents increases up to 20-fold before vascular damage occurs on heating at 43 0 -45 0 C. It thus appears that the vascular beds in tumors are more vulnerable to heat than those in normal tissues. Because of the large increase in blood flow in normal tissue on heating, heat dissipation by blood flow is usually greater in normal tissues than that in tumors during heating. Consequently, the temperature of tumors may rise higher than that in normal tissues. Preferential heating of tumors, however, may not be achieved all the time because the relative blood perfusion in some tumors or in parts of a tumor remains greater than that in the surrounding normal tissues. The intrinsically acidic intratumor environment becomes further acidic on heating owing to an increase in the synthesis of acidic metabolites and retarded removal of them as a result of heat-induced vascular damage. The intratumor environment also becomes hypoxic as a result of retardation of blood flow and vascular damage after heating

  20. Analgesics and sedatives in vascular interventionist radiologic

    International Nuclear Information System (INIS)

    Gregorio, M.A. de; Opta, J.M.; Pulido, J.M.; Encarnacion, C.E.; Arino, I., Fernandez, J.A.; Alfonso, E.R.

    1993-01-01

    Interventionist radiology routinely requires the use of different drugs (analgesics and sedatives) in the course of a procedure. Aside from their therapeutic action, these drugs can produce secondary or undesirable effects, making necessary an in-depth knowledge of them to assure their safe and efficient management. The aim of this work is to provide the vascular interventionist radiologist with additional information on the management of those drugs that contribute to minimizing patient discomfort and pain in interventionist procedures. Author

  1. Robotic vascular resections during Whipple procedure

    OpenAIRE

    Allan, Bassan J.; Novak, Stephanie M.; Hogg, Melissa E.; Zeh, Herbert J.

    2018-01-01

    Indications for resection of pancreatic cancers have evolved to include selected patients with involvement of peri-pancreatic vascular structures. Open Whipple procedures have been the standard approach for patients requiring reconstruction of the portal vein (PV) or superior mesenteric vein (SMV). Recently, high-volume centers are performing minimally invasive Whipple procedures with portovenous resections. Our institution has performed seventy robotic Whipple procedures with concomitant vas...

  2. Endothelial microparticles: Sophisticated vesicles modulating vascular function

    Science.gov (United States)

    Curtis, Anne M; Edelberg, Jay; Jonas, Rebecca; Rogers, Wade T; Moore, Jonni S; Syed, Wajihuddin; Mohler, Emile R

    2015-01-01

    Endothelial microparticles (EMPs) belong to a family of extracellular vesicles that are dynamic, mobile, biological effectors capable of mediating vascular physiology and function. The release of EMPs can impart autocrine and paracrine effects on target cells through surface interaction, cellular fusion, and, possibly, the delivery of intra-vesicular cargo. A greater understanding of the formation, composition, and function of EMPs will broaden our understanding of endothelial communication and may expose new pathways amenable for therapeutic manipulation. PMID:23892447

  3. New molecular probes of vascular inflammation

    International Nuclear Information System (INIS)

    Molecular Cardiovascular Imaging, Westfälische Wilhelms University Münster, Münster, (Germany))" data-affiliation=" (Department of Nuclear Medicine, University Hospital Münster, Münster, and DFG CRC 656 Molecular Cardiovascular Imaging, Westfälische Wilhelms University Münster, Münster, (Germany))" >VRACHIMIS, Alexis; HONOLD, Lisa; Cells in Motion Cluster of Excellence, Westfälische Wilhelms University Münster, Münster, (Germany))" data-affiliation=" (European Institute of Molecular Imaging, Westfälische Wilhelms University Münster, Münster, and DFG EXC 1003 Cells in Motion Cluster of Excellence, Westfälische Wilhelms University Münster, Münster, (Germany))" >FAUST, Andreas; Cells in Motion Cluster of Excellence, Westfälische Wilhelms University Münster, Münster, (Germany))" data-affiliation=" (European Institute of Molecular Imaging, Westfälische Wilhelms University Münster, Münster, and DFG EXC 1003 Cells in Motion Cluster of Excellence, Westfälische Wilhelms University Münster, Münster, (Germany))" >HERMANN, Sven; SCHÄFERS, Michael

    2016-01-01

    New molecular imaging approaches featuring the assessment of inflammatory processes in the vascular wall on top of existing anatomic and functional vessel imaging procedures could emerge as decisive tools for the understanding and prevention of cardiovascular events. In this respect imaging approaches addressing specific molecular and cellular targets in atherosclerosis are of high interest. This review summarizes the rationale and current status of nuclear imaging probes which possess high translational potential.

  4. Early Vascular Ageing - A Concept in Development.

    Science.gov (United States)

    M Nilsson, Peter

    2015-04-01

    Cardiovascular disease (CVD) is a prevalent condition in the elderly, often associated with metabolic disturbance and type 2 diabetes. For a number of years, research dedicated to understand atherosclerosis dominated, and for many good reasons, this pathophysiological process being proximal to the CVD events. In recent years, research has been devoted to an earlier stage of vascular pathology named arteriosclerosis (arterial stiffness) and the new concept of early vascular ageing (EVA), developed by a group of mostly European researchers. This overview describes recent developments in research dedicated to EVA and new emerging aspects found in studies of families at high cardiovascular risk. There are new aspects related to genetics, telomere biology and the role of gut microbiota. However, there is still no unifying definition available of EVA and no direct treatment, but rather only recommendations for conventional cardiovascular risk factor control. New interventions are being developed - not only new antihypertensive drugs, but also new drugs for vascular protection - the selective angiotensin-II (AT2) agonist Compound 21 (C21). Human studies are eagerly awaited. Even new functional food products could have the potential to positively influence cardiometabolic regulation, to be confirmed.

  5. Altos custos financeiros do trauma vascular

    Directory of Open Access Journals (Sweden)

    Ricardo Costa-Val

    Full Text Available OBJETIVO: Demonstrar o custo e impacto financeiro referente à primeira abordagem cirúrgica das lesões vasculares em pacientes admitidos no Hospital João XXIII/FHEMIG, entre os anos de 2004 a 2006. MéTODOS: Trata-se de um estudo com aprovação ética, retrospectivo, de coorte e descritivo realizado a partir da auditoria de contas hospitalares referentes a 70 prontuários catalogados pelo Serviço de Trauma Cardiovascular. RESULTADOS: Cinco (7,14% prontuários foram excluídos por má qualidade técnica. O valor monetário repassado pelo Sistema Único de Saúde e pelo setor privado foram de R$ 103.614,96 (US$ 60.949,97 e de R$ 185.888,21 (US$ 109.346,0, respectivamente, implicando em defasagem potencial de 44%. Houve correlação direta entre custos e topografia anatômica das lesões e exponencial em relação às variáveis hemoderivados e próteses vasculares. CONCLUSÃO: Este estudo corrobora os altos custos do trauma vascular e fortalece a importância da auditoria de contas para as tomadas de decisões médicas.

  6. Pancreatic transplantation: Radiologic evaluation of vascular complications

    International Nuclear Information System (INIS)

    Snider, J.F.; Hunter, D.W.; Kuni, C.C.; Castaneda-Zuniga, W.R.; Letourneau, J.G.

    1991-01-01

    Transplantation of the pancreas is an increasingly common therapeutic option for preventing or delaying complications of type I diabetes mellitus. The authors studied the relative roles of various radiologic examinations in diagnosing vascular complications in these grafts including arterial and venous thrombosis, stenosis, and anastomotic leak (the most common vascular factors that necessitate pancreatectomy of the transplant), as defined with pathologic or arteriographic data. The results of 78 scintigraphic flow studies, 40 abdominal and pelvic computed tomographic (CT) scans, 27 sonograms, and eight color Doppler studies were evaluated in 52 patients who received a total of 27 cadaveric and 26 living-donor grafts over a 12-year period. These results were correlated with the data from 45 gross and microscopic pathologic studies and 37 arteriograms to determine their relative value in enabling detection of graft thrombosis and other vascular complications. Scintigraphy, CT, sonography, and color Doppler were all sensitive in detection of generalized graft abnormalities but lacked specificity in defining the underlying etiologic factors

  7. Pancreatic transplantation: Radiologic evaluation of vascular complications

    Energy Technology Data Exchange (ETDEWEB)

    Snider, J.F.; Hunter, D.W.; Kuni, C.C.; Castaneda-Zuniga, W.R.; Letourneau, J.G. (Univ. of Minnesota Hospital and Clinic, Minneapolis (USA))

    1991-03-01

    Transplantation of the pancreas is an increasingly common therapeutic option for preventing or delaying complications of type I diabetes mellitus. The authors studied the relative roles of various radiologic examinations in diagnosing vascular complications in these grafts including arterial and venous thrombosis, stenosis, and anastomotic leak (the most common vascular factors that necessitate pancreatectomy of the transplant), as defined with pathologic or arteriographic data. The results of 78 scintigraphic flow studies, 40 abdominal and pelvic computed tomographic (CT) scans, 27 sonograms, and eight color Doppler studies were evaluated in 52 patients who received a total of 27 cadaveric and 26 living-donor grafts over a 12-year period. These results were correlated with the data from 45 gross and microscopic pathologic studies and 37 arteriograms to determine their relative value in enabling detection of graft thrombosis and other vascular complications. Scintigraphy, CT, sonography, and color Doppler were all sensitive in detection of generalized graft abnormalities but lacked specificity in defining the underlying etiologic factors.

  8. Arterial vascularization of the pineal gland.

    Science.gov (United States)

    Kahilogullari, Gokmen; Ugur, Hasan Caglar; Comert, Ayhan; Brohi, Recep Ali; Ozgural, Onur; Ozdemir, Mevci; Karahan, Suleyman Tuna

    2013-10-01

    The arterial vascularization of the pineal gland (PG) remains a debatable subject. This study aims to provide detailed information about the arterial vascularization of the PG. Thirty adult human brains were obtained from routine autopsies. Cerebral arteries were separately cannulated and injected with colored latex. The dissections were carried out using a surgical microscope. The diameters of the branches supplying the PG at their origin and vascularization areas of the branches of the arteries were investigated. The main artery of the PG was the lateral pineal artery, and it originated from the posterior circulation. The other arteries included the medial pineal artery from the posterior circulation and the rostral pineal artery mainly from the anterior circulation. Posteromedial choroidal artery was an important artery that branched to the PG. The arterial supply to the PG was studied comprehensively considering the debate and inadequacy of previously published studies on this issue available in the literature. This anatomical knowledge may be helpful for surgical treatment of pathologies of the PG, especially in children who develop more pathology in this region than adults.

  9. VASCULAR REMODELING IN HYPERTENSION: ANGIOGENESIS FEATURES

    Directory of Open Access Journals (Sweden)

    L. A. Haisheva

    2014-07-01

    Full Text Available Aim — cross-sectional study of changes in various segments of the vascular bed in arterial hypertension (AH, defining the role of inducers and inhibitors of angiogenesis in these processes.Materials and methods. The study included 99 patients with arterial hypertension of I–II degree, average age of 63.2 ± 2.6 years, diseaseduration 9.2 ± 7.2 years.Results. It was found that patients with arterial hypertension have disorders in all segments of vascular bed: endothelial dysfunction (highvWF, microcirculatory disorders, and increased pulse wave velocity (PWV of elastic-type vessels. The level of angioginesis factors doesnot depend on such parameters as gender, age, body mass index. Smoking and duration of hypertension influence on vascular endothelialgrowth factor raise and endostatin levels are higher in patients with family history of cardiovascular diseases. Duration of disease is directlycorrelated with microcirculatory disorders and the PWV, correlation between microcirculatory disorders and pulse wave velocity indicatetheir common processes.

  10. Amplatzer vascular plugs in congenital cardiovascular malformations

    International Nuclear Information System (INIS)

    Barwad, Parag; Ramakrishnan, Sivasubramanian; Kothari, Shyam S; Saxena, Anita; Gupta, Saurabh K; Juneja, Rajnish; Gulati, Gurpreet Singh; Jagia, Priya; Sharma, Sanjiv

    2013-01-01

    Amplatzer vascular plugs (AVPs) are devices ideally suited to close medium-to-large vascular communications. There is limited published literature regarding the utility of AVPs in congenital cardiovascular malformations (CCVMs). To describe the use of AVPs in different CCVMs and to evaluate their safety and efficacy. All patients who required an AVP for the closure of CCVM were included in this retrospective review of our catheterization laboratory data. The efficacy and safety of AVPs are reported. A total of 39 AVPs were implanted in 31 patients. Thirteen (33%) were AVP type I and 23 (59%) were AVP type II. AVP type III were implanted in two patients and type IV in one patient. The major indications for their use included closure of pulmonary arteriovenous malformation (AVM) (n = 7), aortopulmonary collaterals (n = 7), closure of a patent Blalock-Taussig shunt (n = 5), systemic AVM (n = 5), coronary AVM (n = 4), patent ductus arteriosus (PDA) (n = 3), pulmonary artery aneurysms (n = 3), and venovenous collaterals (n = 2). Deployment of the AVP was done predominantly via the 5 – 7F Judkin's right coronary guide catheter. Overall 92% of the AVPs could be successfully deployed and resulted in occlusion of the target vessel in all cases, within 10 minutes. No procedure-related or access site complication occurred. AVPs are versatile, easy to use, and effective devices to occlude the vascular communications in a variety of settings. AVP II is especially useful in the closure of tubular structures with a high flow

  11. Vascular development in the vertebrate pancreas

    Science.gov (United States)

    Azizoglu, D. Berfin; Chong, Diana C.; Villasenor, Alethia; Magenheim, Judith; Barry, David M.; Lee, Simon; Marty-Santos, Leilani; Fu, Stephen; Dor, Yuval; Cleaver, Ondine

    2016-01-01

    The vertebrate pancreas is comprised of a highly branched tubular epithelium, which is intimately associated with an extensive and specialized vasculature. While we know a great deal about basic vascular anatomy of the adult pancreas, as well as islet capillaries, surprisingly little is known about the ontogeny of its blood vessels. Here, we analyze development of the pancreatic vasculature in the mouse embryo. We show that pancreatic epithelial branches intercalate with the fine capillary plexus of the surrounding pancreatic mesenchyme. Endothelial cells (ECs) within this mesenchyme are heterogeneous from the onset of organogenesis. Pancreatic arteries take shape before veins, in a manner analogous to early embryonic vessels. The main central artery forms during mid-gestation, as a result of vessel coalescence and remodeling of a vascular plexus. In addition, we show that vessels in the forming pancreas display a predictable architecture that is dependent on VEGF signaling. Over-expression of VEGF disrupts vascular patterning and arteriovenous differentiation within the developing pancreas. This study constitutes a first-time cellular and molecular characterization of pancreatic blood vessels, as they coordinately grow along with the pancreatic epithelium. PMID:27789228

  12. Vascularized nerve grafts: an experimental study.

    Science.gov (United States)

    Donzelli, Renato; Capone, Crescenzo; Sgulò, Francesco Giovanni; Mariniello, Giuseppe; Maiuri, Francesco

    2016-08-01

    The aim of this study is to define an experimental model in order to promote the functional recovery of the nerves using grafts with vascular support (Vascular Nerve Grafts - VNG). The aim of this study is to define, on an experimental model in normal recipient bed, whether the functional recovery with VNG is superior to that obtained non-vascularized graft (NNG). Twenty male rabbits, which underwent dissection of sciatic nerve, were later treated by reinnervation through an autograft. In 10 animals the reconstruction of sciatic nerve was realized with VNG; in 10 control animals the reconstruction of sciatic nerve was realized with NNG. The VNG group showed a better axonal organization and a significantly higher number of regenerated axons in the early phases (after 30 days) than the NNG group, whereas the difference in the axonal number at day 90 was less significant; besides, the axon diameter and the myelin thickness were not significantly improved by VNG group. Our data suggests that the use of VNG leads to a faster regeneration process and a better functional recovery, although the final results are comparable to those of the NNG. VNG improve the quality of the axonal regeneration (axonal diameter and Schwann cells), although the increase in the axonal number is not significant and does not improve the long-term functional outcome.

  13. Vascular nitric oxide: Beyond eNOS

    Directory of Open Access Journals (Sweden)

    Yingzi Zhao

    2015-10-01

    Full Text Available As the first discovered gaseous signaling molecule, nitric oxide (NO affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources in the blood vessel wall. NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC to produce cyclic guanosine monophosphate (cGMP, although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA or production of cyclic inosine monophosphate (cIMP] also can be involved. In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite. Dysfunction in the production and/or the bioavailability of NO characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis.

  14. Vascular development in the vertebrate pancreas.

    Science.gov (United States)

    Azizoglu, D Berfin; Chong, Diana C; Villasenor, Alethia; Magenheim, Judith; Barry, David M; Lee, Simon; Marty-Santos, Leilani; Fu, Stephen; Dor, Yuval; Cleaver, Ondine

    2016-12-01

    The vertebrate pancreas is comprised of a highly branched tubular epithelium, which is intimately associated with an extensive and specialized vasculature. While we know a great deal about basic vascular anatomy of the adult pancreas, as well as islet capillaries, surprisingly little is known about the ontogeny of its blood vessels. Here, we analyze development of the pancreatic vasculature in the mouse embryo. We show that pancreatic epithelial branches intercalate with the fine capillary plexus of the surrounding pancreatic mesenchyme. Endothelial cells (ECs) within this mesenchyme are heterogeneous from the onset of organogenesis. Pancreatic arteries take shape before veins, in a manner analogous to early embryonic vessels. The main central artery forms during mid-gestation, as a result of vessel coalescence and remodeling of a vascular plexus. In addition, we show that vessels in the forming pancreas display a predictable architecture that is dependent on VEGF signaling. Over-expression of VEGF disrupts vascular patterning and arteriovenous differentiation within the developing pancreas. This study constitutes a first-time in-depth cellular and molecular characterization of pancreatic blood vessels, as they coordinately grow along with the pancreatic epithelium. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Electrotonic vascular signal conduction and nephron synchronization

    DEFF Research Database (Denmark)

    Marsh, D.J.; Toma, I.; Sosnovtseva, Olga

    2009-01-01

    Marsh DJ, Toma I, Sosnovtseva OV, Peti-Peterdi J, Holstein-Rathlou NH. Electrotonic vascular signal conduction and nephron synchronization. Am J Physiol Renal Physiol 296: F751-F761, 2009. First published December 30, 2008; doi:10.1152/ajprenal.90669.2008.-Tubuloglomerular feedback (TGF) and the ......Marsh DJ, Toma I, Sosnovtseva OV, Peti-Peterdi J, Holstein-Rathlou NH. Electrotonic vascular signal conduction and nephron synchronization. Am J Physiol Renal Physiol 296: F751-F761, 2009. First published December 30, 2008; doi:10.1152/ajprenal.90669.2008.-Tubuloglomerular feedback (TGF......) and the myogenic mechanism control afferent arteriolar diameter in each nephron and regulate blood flow. Both mechanisms generate self-sustained oscillations, the oscillations interact, TGF modulates the frequency and amplitude of the myogenic oscillation, and the oscillations synchronize; a 5: 1 frequency ratio...... is the most frequent. TGF oscillations synchronize in nephron pairs supplied from a common cortical radial artery, as do myogenic oscillations. We propose that electrotonic vascular signal propagation from one juxtaglomerular apparatus interacts with similar signals from other nephrons to produce...

  16. Efecto agudo y retardado de siete tipos de estímulos diferentes sobre la capacidad de salto y efecto de ocho estímulos diferentes sobre la capacidad de salto y la velocidad de desplazamiento

    Directory of Open Access Journals (Sweden)

    Eduardo Sáez Sáez de Villarreal

    2008-06-01

    Full Text Available Se realizaron 3 estudios experimentales para determinar el efecto agudo y retardado de diferentes estímulos sobre la capacidad de salto (CSV y velocidad de desplazamiento (VD. En el primer estudio comprobamos el efecto de 7 tipos de estímulos de activación muscular sobre la CSV a corto y largo plazo (5 min-6 h. 12 jugadores de voleibol de 1ª división, realizaron diferentes estímulos de activación aleatoriamente. La utilización de movimientos dinámicos con cargas de alta intensidad (80-95% 1RMSP así como protocolos de calentamiento específicos para el voleibol generaron mejores efectos neuromusculares sobre las acciones explosivas realizadas a corto plazo (5 min.. Los efectos agudos positivos sobre la CSV tras una óptima activación fueron mantenidos después de largos periodos de descanso (6 horas, cuando se realizaron acciones dinámicas de alta intensidad. En el segundo estudio examinamos el efecto de tres frecuencias de entrenamiento pliométrico (1, 2 y 4 días/sem durante un programa de 7 semanas, sobre la CSV, la VD la fuerza máxima (FM y explosiva (FE. 42 estudiantes fueron aleatoriamente asignados en 4 grupos experimentales. El entrenamiento incluía saltos drop jump (DJ desde 20-40-60 cm. El tratamiento (2 días/sem, 840 saltos produjo similares mejoras en la CSV, aunque fue más eficiente (~12% y 0,014%/salto cuando se comparó con un volumen de (4 días/sem, 1.680 saltos (~18% y 0,011%/saltos. Se observaron mejoras similares en la VD en 20m y en la FM tanto utilizando un moderado o bajo como un alto volumen de entrenamiento, a pesar de que el número medio de saltos realizados por el grupo 7S (420 saltos y 14S (840 saltos fue un 25% y un 50% de los realizados por el grupo 28S (1680 saltos. En el tercer estudio examinamos el efecto retardado de 5 estímulos diferentes sobre la CSV y la VD después de 7 semanas de entrenamiento. 63 estudiantes fueron aleatoriamente asignados en 5 grupos experimentales. Se produjo una mejora

  17. Acute splenic sequestration in a pregnant woman with homozygous sickle-cell anemia Sequestro esplênico agudo em uma mulher grávida com anemia falciforme homozigótica

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    Carolina Bastos Maia

    2013-04-01

    Full Text Available CONTEXT Homozygous (SS sickle-cell anemia complicated by acute splenic sequestration in adults is a rare event, and it has never been reported during pregnancy. CASE REPORT A 25-year-old woman with homozygous (SS sickle-cell disease was hospitalized at 32 weeks' of gestation presenting weakness, abdominal pain, fever and hemoglobin of 2.4 g/dl. Abnormal fetal heart rate was detected by means of cardiotocography, and 5 units of packed red cells were transfused. Cesarean was performed at 37 weeks. Both mother and baby were discharged in a good general condition. CONCLUSION This case report demonstrates the importance of immediate blood transfusion for treatment of fetal distress in cases of splenic sequestration during pregnancy. This treatment is essential for avoiding maternal and fetal complications. CONTEXTO Anemia falciforme homozigótica (SS complicada por sequestro esplênico agudo em adultos é evento raro, e nunca foi relatado durante a gravidez. RELATO DO CASO Uma mulher de 25 anos, portadora de doença falciforme homozigótica (SS, com 32 semanas de gestação, foi internada apresentando fraqueza, dor abdominal, febre e hemoglobina de 2,4 g/dl. Frequência cardíaca fetal anormal foi detectada pela cardiotocografia e a paciente recebeu 5 unidades de concentrado de hemácias. Cesariana foi realizada com 37 semanas. Mãe e filho receberam alta em bom estado geral. CONCLUSÃO Este relato de caso demonstra a importância da transfusão imediata para o tratamento de sofrimento fetal nos casos de sequestro esplênico durante a gestação. Este tratamento é imprescindível para se evitarem complicações maternas e fetais.

  18. Pseudo-aneurisma de ventrículo esquerdo por rotura cardíaca após infarto agudo do miocárdio: tratamento cirúrgico

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    GOMES Maurício de Castro

    1997-01-01

    Full Text Available O pseudo-aneurisma de ventrículo esquerdo após infarto agudo do miocárdio é entidade rara. Quando diagnosticado, deverá ser operado logo que possível, devido ao risco aumentado de rotura de sua parede. No período de novembro de 1992 a junho de 1995, foram encaminhados ao nosso Serviço 3 pacientes com suspeita clínica de pseudo-aneurisma de ventrículo esquerdo (VE, com sinais clínicos, radiológicos, ecocardiográficos e angiográficos característicos da lesão. O objetivo do trabalho é discutir o diagnóstico, a indicação cirúrgica, as técnicas e táticas empregadas, as complicações e os resultados cirúrgicos. Todos os pacientes foram submetidos ao ecodopplercardiograma transtorácico, que foi suficiente para o diagnóstico. Após propedêutica adequada, com realização de angiografia e ventriculografia, os pacientes foram submetidos à correção utilização de pericárdio bovino. Um dos pacientes apresentava comunicação interventricular (CIV, que foi corrigida no mesmo ato cirúrgico. Os pacientes receberam alta em bom estado geral, com controle ecocardiográfico evidenciando a correção do pseudo-aneurisma.

  19. Trastorno de estrés agudo y episodio depresivo mayor en víctimas de una inundación en Tingo María: prevalencia y efectos de su desplazamiento a un alberg

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    Yliana Rojas-Medina

    2008-01-01

    Full Text Available Objetivos. Determinar la prevalencia del trastorno de estrés agudo (TEA y comorbilidad con episodio depresivo mayor (TEA+EDM en víctimas de la inundación de la ciudad Tingo María-Huánuco, 20 días después del evento traumático. Materiales y métodos. Ciento veinte damnificados (personas del albergue y 110 afectados (personas en sus viviendas fueron encuestados y comparados. Se aplicó la entrevista clínica estructurada para los trastornos del Eje I del DSM-IV, versión clínica. Las prevalencias de los trastornos estudiados fueron estratificadas por edad, ser mujer, tener una pareja al tiempo de ocurrencia del desastre, estar desempleado cuando ocurrió el desastre, no hablar castellano y tener un nivel de instrucción bajo. Los datos fueron analizados en STATA v.8.0. Resultados. El 64,8% (IC95%: 58,6 -71,0 de la población estudiada fue diagnosticada con TEA y un 28,3% (IC95%: 22,4 - 34,1 tuvo TEA+EDM. Los damnificados mostraron prevalencias mayores de TEA, 80%, frente a 48,2% en los afectados (p<0,001. Para el caso de TEA+EDM las prevalencias fueron 40,0% y 15,5%, respectivamente (p<0,001. Las mujeres tienen mayor riesgo de desarrollar TEA (OR: 4,3; IC 95% 1,6-11,2 y TEA + EDM (OR: 8,7; IC 95% 1,9-40,9 independientemente de los otros factores. Conclusiones. Existe diferencias importantes entre las prevalencias de trastornos mentales de las personas que habitan en un albergue o en su vivienda; siendo mayor en quienes se ven obligados a vivir temporalmente en albergues. Las mujeres son más propensas a sufrir estos trastornos mentales.

  20. Morphoquantitative effects of acute diabetes on the myenteric neurons of the proximal colon of adult rats Efeitos morfoquantitativos do diabetes agudo sobre os neurônios mioentéricos do colo proximal de ratos adultos

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    Maria Montserrat D.P. Furlan

    2002-09-01

    Full Text Available The effects of acute diabetes on the density and size of the myenteric neurons of the proximal colon of adult rats were investigated. The injection of streptozotocin was followed by a period of observation of seven days, during which the diabetic animals showed weight loss, excessive food and water intake, large urinary debt and hyperglicemia. The whole-mounts from the proximal colon were stained with the techniques of Giemsa and of the NADH-diaphorase, and the employment of these techniques made it possible to verify a decrease on the neuronal density and on the cell body size of the myenteric neurons in the colon of the diabetic rats. These observations were discussed in terms of the pathophysiology of the diabetes and the experimental protocol.Foram investigados os efeitos do diabetes agudo sobre a densidade e o tamanho dos neurônios mioentéricos do colo proximal de ratos adultos. À injeção de estreptozootocina seguiu-se um período de observação de sete dias, durante os quais os animais diabéticos apresentaram perda de peso, ingestão excessiva de alimento e água, grande débito urinário e hiperglicemia. Os preparados de membrana do colo proximal foram corados pelas técnicas de Giemsa e da NADH-diaforase. A aplicação dessas técnicas permitiu constatar uma redução da densidade neuronal e do tamanho do corpo celular dos neurônios mioentéricos no colo dos ratos diabéticos. Essas observações foram discutidas em termos da patofisiologia do diabetes e do protocolo experimental.

  1. Infarto agudo del miocardio como primera manifestación del síndrome antifosfolípido primario en un paciente de veinticuatro años Acute myocardial infarction as first manifestation of primary antiphospholipid syndrome in a twenty-four years old patient

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    Carlos E Uribe

    2005-09-01

    Full Text Available El síndrome antifosfolípido primario usualmente se manifiesta como trombosis venosa profunda, tromboembolismo pulmonar y como evento cerebrovascular en la circulación arterial. Se presenta el caso de un paciente joven previamente sano, con infarto agudo del miocardio como primera manifestación del síndrome antifosfolípido primario.Primary antiphospholipid syndrome is usually manifested with deep venous thrombosis, pulmonary thromboembolism and arterial thrombosis, including cerebrovascular accidents. We report the case of a previously healthy young patient who suffered an acute myocardial infarction as the first manifestation of a primary antiphospholipid syndrome.

  2. Efecto de la Exposición a un Protocolo de Estrés Social Agudo sobre los Niveles Sistémicos de Cortisol y la Ejecución de una Tarea de Atención Sostenida y Dividida

    OpenAIRE

    OLGA TARAZONA; JEIMMY CERÓN; MARISOL LAMPREA

    2013-01-01

    La presente investigación tuvo como objetivo determinar los efectos del estrés social agudo inducido experimentalmente con una versión modificada del TSST (Trier Social Stress Test), en los niveles sistémicos de la hormona cortisol y en la ejecución de una tarea de atención sostenida y dividida, en estudiantes universitarios de ambos sexos. Los resultados mostraron que el protocolo modificado del TSST produjo incrementos en los niveles sistémicos de cortisol en los participantes de sexo mascu...

  3. Escore de risco Dante Pazzanese para síndrome coronariana aguda sem supradesnivelamento do segmento ST Score de riesgo dante pazzanese para síndrome coronario agudo sin supradesnivel del segmento ST Dante Pazzanese risk score for non-st-segment elevation acute coronary syndrome

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    Elizabete Silva dos Santos

    2009-10-01

    Full Text Available FUNDAMENTO: Em síndrome coronariana aguda (SCA, é importante estimar a probabilidade de eventos adversos. OBJETIVO: Desenvolver um escore de risco em uma população brasileira com SCA sem supradesnivelamento do segmento ST (SST. MÉTODOS: Foram avaliados prospectivamente 1.027 pacientes em um centro brasileiro de cardiologia. Um modelo de regressão logística múltipla foi desenvolvido para prever o risco de morte ou de (reinfarto em 30 dias. A acurácia preditiva do modelo foi determinada pelo C statistic. RESULTADOS: O evento combinado ocorreu em 54 pacientes (5,3%. O escore foi criado pela soma aritmética de pontos dos preditores independentes, cujas pontuações foram designadas pelas respectivas probabilidades de ocorrência do evento. As seguintes variáveis foram identificadas: aumento da idade (0 a 9 pontos; antecedente de diabete melito (2 pontos ou de acidente vascular cerebral (4 pontos; não utilização prévia de inibidor da enzima conversora da angiotensina (1 ponto; elevação da creatinina (0 a 10 pontos; e combinação de elevação da troponina I cardíaca e depressão do segmento ST (0 a 4 pontos. Foram definidos quatro grupos de risco: muito baixo (até 5 pontos; baixo (6 a 10 pontos; intermediário (11 a 15 pontos; e alto risco (16 a 30 pontos. O C statistic para a probabilidade do evento foi de 0,78 e para o escore de risco em pontuação de 0,74. CONCLUSÃO: Um escore de risco foi desenvolvido para prever morte ou (reinfarto em 30 dias em uma população brasileira com SCA sem SST, podendo facilmente ser aplicável no departamento de emergência.FUNDAMENTO: En el síndrome coronario agudo (SCA, es importante estimar la probabilidad de eventos adversos. OBJETIVO: Desarrollar un score de riesgo en una población brasileña con SCA sin supradesnivel del segmento ST (SST. MÉTODOS: Se evaluaron prospectivamente 1.027 pacientes en un centro brasileño de cardiología. Un modelo de regresión logística múltiple se

  4. Watermelon stomach: clinical aspects and treatment with argon plasma coagulation Ectasia vascular do antro gástrico ("watermelon stomach": aspectos clínicos e tratamento com coagulação com plasma de argônio

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    Dalton M. Chaves

    2006-09-01

    exibiam ectasia vascular do antro gástrico de aspecto difuso confluente ou estriado. Grupo II - 10 pacientes que apresentavam aspecto difuso pontilhado não-confluente. RESULTADOS: Todos os pacientes do grupo I apresentavam auto-anticorpos, exceto um paciente no qual não foi pesquisado. Três eram cirróticos, três tinham hipotireoidismo e todos apresentavam gastrite atrófica. No grupo II, todos tinham doença hepática não-autoimune, com plaquetas menores que 90.000. Dez pacientes foram submetidos a tratamento com coagulação com plasma de argônio, com 2 a 36 meses de seguimento. A ectasia vascular do antro gástrico recorreu em todos os pacientes que continuaram em acompanhamento e um paciente não respondeu ao tratamento para controle de sangramento agudo. CONCLUSÃO: Observou-se a existência de dois grupos distintos de pacientes com ectasia vascular do antro gástrico: um grupo associado a distúrbios imunológicos e outro com doença hepática não auto-imune e plaquetopenia. O tratamento com coagulação com plasma de argônio apresentou alta recurrência das ectasias vasculares.

  5. Contribuição do cuidado clínico de enfermagem para o conforto psicoespiritual de mulheres com infarto agudo do miocárdio Contribución del cuidado clínico de enfermería para el confort psicoespiritual de mujeres con infarto agudo de miocardio Contribution of nursing clinical care for psycho-spiritual comfort of women with acute myocardial infarction

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    Keila Maria de Azevedo Ponte

    2012-12-01

    Full Text Available Objetivou-se analisar a contribuição do cuidado clínico de enfermagem para o conforto psicoespiritual de mulheres com Infarto Agudo do Miocárdio (IAM, mediado pela pesquisa-cuidado com base na Teoria do Conforto. Os sujeitos foram nove mulheres admitidas com IAM no período de abril a junho de 2011 em um hospital de Cardiologia em Sobral - Ceará, Brasil. O primeiro encontro ocorreu na admissão e durou em média seis horas; depois ocorreram mais três encontros. Para coleta e análise das informações, foram empregados entrevista individual semiestruturada, diário de campo, observação participante e análise temática categorial de conteúdo. Os cuidados implementados no contexto psicoespiritual foram: fortalecer a espiritualidade, esclarecer sobre o adoecimento, ajudar no enfrentamento da nova condição de saúde e nas situações de confusão mental e desorientação. A percepção do conforto psicoespiritual ocorreu por meio da implementação de cuidados clínicos neste contexto, utilizando-se pesquisa-cuidado com base na Teoria do Conforto.El objetivo del estudio fue analizar la contribución de la atención clínica de enfermería para el confort psicoespiritual de mujeres con Infarto Agudo del Miocardio (IAM, mediada por la investigación-atención basada en la Teoría del Confort. Participaron nueve mujeres que ingresaron con IAM entre abril y junio de 2011 en el hospital de Cardiología de Sobral, Ceará, Brasil. El primer encuentro ocurrió en la admisión y duró alrededor de seis horas, después ocurrieron más tres encuentros. Para recolección y análisis de las informaciones, se utilizaron entrevista semi-estructurada, diarios de campo, observación participante y análisis temático categorial de contenido. Las atenciones psicoespirituales fueron: fortalecer la espiritualidad, aclarar las dudas sobre la enfermedad, ayudar a enfrentarse el nuevo estado de salud y las situaciones de confusión mental y desorientación. La

  6. Expression of Vascular Endothelial Growth Factor Receptors in Benign Vascular Lesions of the Orbit: A Case Series.

    Science.gov (United States)

    Atchison, Elizabeth A; Garrity, James A; Castillo, Francisco; Engman, Steven J; Couch, Steven M; Salomão, Diva R

    2016-01-01

    Vascular lesions of the orbit, although not malignant, can cause morbidity because of their location near critical structures in the orbit. For the same reason, they can be challenging to remove surgically. Anti-vascular endothelial growth factor (VEGF) drugs are increasingly being used to treat diseases with prominent angiogenesis. Our study aimed to determine to what extent VEGF receptors and their subtypes are expressed on selected vascular lesions of the orbit. Retrospective case series of all orbital vascular lesions removed by one of the authors (JAG) at the Mayo Clinic. A total of 52 patients who underwent removal of vascular orbital lesions. The pathology specimens from the patients were retrieved, their pathologic diagnosis was confirmed, demographic and clinical information were gathered, and sections from vascular tumors were stained with vascular endothelial growth factor receptor (VEGFR), vascular endothelial growth factor receptor type 1 (VEGFR1), vascular endothelial growth factor receptor type 2 (VEGFR2), and vascular endothelial growth factor receptor type 3 (VEGFR3). The existence and pattern of staining with VEGF and its subtypes on these lesions. There were 28 specimens of venous malformations, 4 capillary hemangiomas, 7 lymphatic malformations, and 6 lymphaticovenous malformations. All samples stained with VEGF, 55% stained with VEGFR1, 98% stained with VEGFR2, and 96% stained with VEGFR3. Most (94%) of the VEGFR2 staining was diffuse. Most orbital vascular lesions express VEGF receptors, which may suggest a future target for nonsurgical treatment. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

  7. Ecocardiografia por Doppler tecidual no diagnóstico de rejeição após transplante cardíaco Ecocardiografía con Doppler tisular en el diagnóstico de rechazo después de transplante cardíaco Tissue doppler echocardiography in the diagnosis of heart transplantation rejection

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    Marcos Valério Coimbra Resende

    2011-07-01

    Full Text Available FUNDAMENTO: A biópsia endomiocárdica (BEM é o método padrão-ouro para o diagnóstico de rejeição celular (RC após transplante cardíaco (TC. OBJETIVO: Testar a hipótese de que o exame de imagem por Doppler tecidual (IDT pode detectar RC > 3A e agregar informação diagnóstica, comparado ao Doppler convencional. MÉTODOS: Cinquenta e quatro pacientes com TC foram submetidos à BEM e estudo ecocardiográfico através de IDT em até 24 horas. Comparamos os pacientes com TC e RC > 3A com pacientes com TC e RC 3A em 39/129 (30,2% das BEM. O melhor preditor isolado para o diagnóstico de RC foi a a'LAT, com sensibilidade de 76,3%, especificidade de 73,8% (p = 0,001. Na análise multivariada, a a'LAT (p = 0,001, a'SEP (p = 0,002, relação e'/a' LAT (p = 0,006, relação e'Mitral/ e'LAT (p = 0,014, SINF (p = 0,009 foram preditores de RC > 3A. Obtivemos um escore com sensibilidade de 88,2%, acurácia de 79,6%, e valor preditivo negativo de 92,9% para diagnosticar RC > 3A. O Doppler convencional (fluxo mitral e pulmonar venoso não foi relevante para predizer a RC > 3A. CONCLUSÃO: O estudo de IDT agregou informação diagnóstica para predizer RC > 3A quando comparado ao Doppler convencional. O modelo baseado em IDT pode ser tornar um método em potencial para detectar RC > 3A após TC.FUNDAMENTO: La biopsia endomiocárdica (BEM es el método gold standard para el diagnóstico de rechazo celular (RC después de transplante cardíaco (TC. OBJETIVO: Testear la hipótesis de que el examen de imagen con Doppler tisular (IDT puede detectar RC > 3A y agregar información diagnóstica, comparado al Doppler convencional. MÉTODOS: Cincuenta y cuatro pacientes con TC fueron sometidos a BEM y estudio ecocardiográfico a través de IDT en hasta 24 horas. Comparamos los pacientes con TC y RC > 3A con pacientes con TC y RC 3A en 39/129 (30,2% de las BEM. El mejor predictor aislado para el diagnóstico de RC fue la a'LAT, con sensibilidad de 76

  8. Retinal vascular segmentation using superpixel-based line operator and its application to vascular topology estimation.

    Science.gov (United States)

    Na, Tong; Xie, Jianyang; Zhao, Yitian; Zhao, Yifan; Liu, Yue; Wang, Yongtian; Liu, Jiang

    2018-05-09

    Automatic methods of analyzing of retinal vascular networks, such as retinal blood vessel detection, vascular network topology estimation, and arteries/veins classification are of great assistance to the ophthalmologist in terms of diagnosis and treatment of a wide spectrum of diseases. We propose a new framework for precisely segmenting retinal vasculatures, constructing retinal vascular network topology, and separating the arteries and veins. A nonlocal total variation inspired Retinex model is employed to remove the image intensity inhomogeneities and relatively poor contrast. For better generalizability and segmentation performance, a superpixel-based line operator is proposed as to distinguish between lines and the edges, thus allowing more tolerance in the position of the respective contours. The concept of dominant sets clustering is adopted to estimate retinal vessel topology and classify the vessel network into arteries and veins. The proposed segmentation method yields competitive results on three public data sets (STARE, DRIVE, and IOSTAR), and it has superior performance when compared with unsupervised segmentation methods, with accuracy of 0.954, 0.957, and 0.964, respectively. The topology estimation approach has been applied to five public databases (DRIVE,STARE, INSPIRE, IOSTAR, and VICAVR) and achieved high accuracy of 0.830, 0.910, 0.915, 0.928, and 0.889, respectively. The accuracies of arteries/veins classification based on the estimated vascular topology on three public databases (INSPIRE, DRIVE and VICAVR) are 0.90.9, 0.910, and 0.907, respectively. The experimental results show that the proposed framework has effectively addressed crossover problem, a bottleneck issue in segmentation and vascular topology reconstruction. The vascular topology information significantly improves the accuracy on arteries/veins classification. © 2018 American Association of Physicists in Medicine.

  9. Accelerated Vascular Aging as a Paradigm for Hypertensive Vascular Disease: Prevention and Therapy.

    Science.gov (United States)

    Barton, Matthias; Husmann, Marc; Meyer, Matthias R

    2016-05-01

    Aging is considered the most important nonmodifiable risk factor for cardiovascular disease and death after age 28 years. Because of demographic changes the world population is expected to increase to 9 billion by the year 2050 and up to 12 billion by 2100, with several-fold increases among those 65 years of age and older. Healthy aging and prevention of aging-related diseases and associated health costs have become part of political agendas of governments around the world. Atherosclerotic vascular burden increases with age; accordingly, patients with progeria (premature aging) syndromes die from myocardial infarctions or stroke as teenagers or young adults. The incidence and prevalence of arterial hypertension also increases with age. Arterial hypertension-like diabetes and chronic renal failure-shares numerous pathologies and underlying mechanisms with the vascular aging process. In this article, we review how arterial hypertension resembles premature vascular aging, including the mechanisms by which arterial hypertension (as well as other risk factors such as diabetes mellitus, dyslipidemia, or chronic renal failure) accelerates the vascular aging process. We will also address the importance of cardiovascular risk factor control-including antihypertensive therapy-as a powerful intervention to interfere with premature vascular aging to reduce the age-associated prevalence of diseases such as myocardial infarction, heart failure, hypertensive nephropathy, and vascular dementia due to cerebrovascular disease. Finally, we will discuss the implementation of endothelial therapy, which aims at active patient participation to improve primary and secondary prevention of cardiovascular disease. Copyright © 2016 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

  10. Revascularization of diaphyseal bone segments by vascular bundle implantation.

    Science.gov (United States)

    Nagi, O N

    2005-11-01

    Vascularized bone transfer is an effective, established treatment for avascular necrosis and atrophic or infected nonunions. However, limited donor sites and technical difficulty limit its application. Vascular bundle transplantation may provide an alternative. However, even if vascular ingrowth is presumed to occur in such situations, its extent in aiding revascularization for ultimate graft incorporation is not well understood. A rabbit tibia model was used to study and compare vascularized, segmental, diaphyseal, nonvascularized conventional, and vascular bundle-implanted grafts with a combination of angiographic, radiographic, histopathologic, and bone scanning techniques. Complete graft incorporation in conventional grafts was observed at 6 months, whereas it was 8 to 12 weeks with either of the vascularized grafts. The pattern of radionuclide uptake and the duration of graft incorporation between vascular segmental bone grafts (with intact endosteal blood supply) and vascular bundle-implanted segmental grafts were similar. A vascular bundle implanted in the recipient bone was found to anastomose extensively with the intraosseous circulation at 6 weeks. Effective revascularization of bone could be seen when a simple vascular bundle was introduced into a segment of bone deprived of its normal blood supply. This simple technique offers promise for improvement of bone graft survival in clinical circumstances.

  11. Vascular Variations Associated with Intracranial Aneurysms.

    Science.gov (United States)

    Orakdogen, Metin; Emon, Selin Tural; Somay, Hakan; Engin, Taner; Is, Merih; Hakan, Tayfun

    2017-01-01

    To investigate the vascular variations in patients with intracranial aneurysm in circle of Willis. We used the data on 128 consecutive intracranial aneurysm cases. Cerebral angiography images were analyzed retrospectively. Arteries were grouped as anterior cerebral arterial system (ACS), posterior cerebral arterial system (PCS) and middle cerebral arterial system (MCS) for grouping vascular variations. Lateralization, being single/multiple, gender; and also any connection with accompanying aneurysms" number, localization, dimension, whether bleeding/incidental aneurysm has been inspected. Variations were demonstrated in 57.8% of the cases. The most common variation was A1 variation (34.4%). The rate of variations was 36.7%, 24.2% and 10.2% respectively in ACS, PCS and MCS. MCS variations were significantly higher in males. Anterior communicating artery (ACoA) aneurysm observance rates were significantly higher and posterior communicating artery (PCoA) aneurysm and middle cerebral artery (MCA) aneurysm observance rates were significantly lower when compared to "no ACS variation detected" cases. In "PCS variation detected" cases, PCoA aneurysm observance rates and coexistence of multiple variations were significantly higher. The rate of vascular variations in patients with aneurysms was 57.8%. Arterial hypoplasia and aplasia were the most common variations. ACS was the most common region that variations were located in; they were mostly detected on the right side. Coexistence of ACoA aneurysm was higher than PCoA and MCA aneurysms. In the PCS variations group, PCoA aneurysms were the most common aneurysms that accompanying the variation and multiple variations were more common than in the other two groups. The variations in MCS were most common in males.

  12. T cells in vascular inflammatory diseases

    Directory of Open Access Journals (Sweden)

    Lucas L Lintermans

    2014-10-01

    Full Text Available Inflammation of the human vasculature is a manifestation of many different diseases ranging from systemic autoimmune diseases to chronic inflammatory diseases, in which multiple types of immune cells are involved. For both autoimmune diseases and chronic inflammatory diseases several observations support a key role for T lymphocytes in these disease pathologies, but the underlying mechanisms are poorly understood. Previous studies in several autoimmune diseases have demonstrated a significant role for a specific subset of CD4+ T cells termed effector memory T cells. This expanded population of effector memory T cells may contribute to tissue injury and disease progression. These cells exert multiple pro-inflammatory functions through the release of effector cytokines. Many of these cytokines have been detected in the inflammatory lesions and participate in the vasculitic reaction, contributing to recruitment of macrophages, neutrophils, dendritic cells, NK cells, B cells and T cells. In addition, functional impairment of regulatory T cells paralyzes anti-inflammatory effects in vasculitic disorders. Interestingly, activation of effector memory T cells in uniquely dependent on the voltage-gated Kv1.3 potassium channel providing an anchor for specific drug targeting. In this review, we focus on the CD4+ T cells in the context of vascular inflammation and describe the evidence supporting the role of different T cell subsets in vascular inflammation. Selective targeting of pathogenic effector memory T cells might enable a more tailored therapeutic approach that avoids unwanted adverse side effects of generalized immunosuppression by modulating the effector functions of T cell responses to inhibit the development of vascular inflammation.

  13. Extraglandular and intraglandular vascularization of canine prostate.

    Science.gov (United States)

    Stefanov, Miroslav

    2004-03-01

    The literature on the vascularization of the canine prostate is reviewed and the clinical significance of prostate morphology is described. Scanning Electron Microscopy (SEM), combined with improved corrosion casting methods, reveal new morphological details that promise better diagnostics and treatment but also require expansion of clinical nomenclature. A proposal is made for including two previously unnamed veins in Nomina Anatomica Veterinaria (NAV). The canine prostate has two lobes with independent vascularization. Each lobe is supplied through the left and right a. prostatica, respectively. The a. prostatica sprouts three small vessels (cranial, middle, and caudal) towards the prostate gland. A. prostatica is a small-size artery whose wall structure is similar to the arteries of the muscular type. V. prostatica is a small-size valved vein. The canine prostate has capsular, parenchymal, and urethral vascular zones. The surface vessels of the capsule are predominantly veins and the diameter of arterial vessels is larger than that of the veins. The trabecular vessels are of two types: direct and branched. The prostate parenchyma is supplied by branches of the trabecular vessels. The periacinary capillaries are fenestrated and form a net in a circular pattern. The processes of the myoepithelial cells embrace both the acins and the periacinar capillaries. In the prostate ductal system. there are spermatozoa. The prostatic part of the urethra is supplied by an independent branch of a. prostatica. The prostatic urethral part is drained by v. prostatica, the vein of the urethral bulb and the ventral prostate veins. M. urethralis begins as early as the urethral prostatic part. The greater part of the white muscle fibers in m. urethralis suggest an enhanced anaerobic metabolism. Copyright 2004 Wiley-Liss, Inc.

  14. Management of bleeding in vascular surgery.

    Science.gov (United States)

    Chee, Y E; Liu, S E; Irwin, M G

    2016-09-01

    Management of acute coagulopathy and blood loss during major vascular procedures poses a significant haemostatic challenge to anaesthetists. The acute coagulopathy is multifactorial in origin with tissue injury and hypotension as the precipitating factors, followed by dilution, hypothermia, acidemia, hyperfibrinolysis and systemic inflammatory response, all acting as a self-perpetuating spiral of events. The problem is confounded by the high prevalence of antithrombotic agent use in these patients and intraoperative heparin administration. Trials specifically examining bleeding management in vascular surgery are lacking, and much of the literature and guidelines are derived from studies on patients with trauma. In general, it is recommended to adopt permissive hypotension with a restrictive fluid strategy, using a combination of crystalloid and colloid solutions up to one litre during the initial resuscitation, after which blood products should be administered. A restrictive transfusion trigger for red cells remains the mainstay of treatment except for the high-risk patients, where the trigger should be individualized. Transfusion of blood components should be initiated by clinical evidence of coagulopathy such as diffuse microvascular bleeding, and then guided by either laboratory or point-of-care coagulation testing. Prophylactic antifibrinolytic use is recommended for all surgery where excessive bleeding is anticipated. Fibrinogen and prothrombin complex concentrates administration are recommended during massive transfusion, whereas rFVIIa should be reserved until all means have failed. While debates over the ideal resuscitative strategy continue, the approach to vascular haemostasis should be scientific, rational, and structured. As far as possible, therapy should be monitored and goal directed. © The Author 2016. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  15. BOLD Granger causality reflects vascular anatomy.

    Directory of Open Access Journals (Sweden)

    J Taylor Webb

    Full Text Available A number of studies have tried to exploit subtle phase differences in BOLD time series to resolve the order of sequential activation of brain regions, or more generally the ability of signal in one region to predict subsequent signal in another region. More recently, such lag-based measures have been applied to investigate directed functional connectivity, although this application has been controversial. We attempted to use large publicly available datasets (FCON 1000, ADHD 200, Human Connectome Project to determine whether consistent spatial patterns of Granger Causality are observed in typical fMRI data. For BOLD datasets from 1,240 typically developing subjects ages 7-40, we measured Granger causality between time series for every pair of 7,266 spherical ROIs covering the gray matter and 264 seed ROIs at hubs of the brain's functional network architecture. Granger causality estimates were strongly reproducible for connections in a test and replication sample (n=620 subjects for each group, as well as in data from a single subject scanned repeatedly, both during resting and passive video viewing. The same effect was even stronger in high temporal resolution fMRI data from the Human Connectome Project, and was observed independently in data collected during performance of 7 task paradigms. The spatial distribution of Granger causality reflected vascular anatomy with a progression from Granger causality sources, in Circle of Willis arterial inflow distributions, to sinks, near large venous vascular structures such as dural venous sinuses and at the periphery of the brain. Attempts to resolve BOLD phase differences with Granger causality should consider the possibility of reproducible vascular confounds, a problem that is independent of the known regional variability of the hemodynamic response.

  16. Cell lineage in vascularized bone transplantation.

    Science.gov (United States)

    Willems, Wouter F; Larsen, Mikko; Friedrich, Patricia F; Bishop, Allen T

    2014-01-01

    The biology behind vascularized bone allotransplantation remains largely unknown. We aim to study cell traffic between donor and recipient following bone auto-, and allografting. Vascularized femoral transplantation was performed with arteriovenous bundle implantation and short-term immunosuppression. Twenty male Piebald Virol Glaxo (PVG; RT1(c) ) rats received isotransplants from female PVG (RT1(c) ) rats and 22 male PVG rats received allografts from female Dark Agouti rats (DA, RT1(a) ), representing a major histocompatibility mismatch. Both groups were randomly analyzed at 4 or 18 weeks. Bone remodeling areas (inner and outer cortical samples) were labeled and laser capture microdissected. Analysis of sex-mismatch genes by real-time reverse transcription-polymerase chain reaction provided the relative Expression Ratio (rER) of donor (female) to recipient (male) cells. The rER was 0.456 ± 0.266 at 4 weeks and 0.749 ± 0.387 at 18 weeks (p = 0.09) in allotransplants. In isotransplants, the rER was 0.412 ± 0.239 and 0.467 ± 0.252 at 4 and 18 weeks, respectively (p = 0.21). At 4 weeks, the rER at the outer cortical area of isotransplants was significantly lower in isotransplants as compared with allotransplants (0.247 ± 0.181 vs. 0.549 ± 0.184, p = 0.007). Cells in the inner and outer cortical bone remodeling areas in isotransplants were mainly donor derived (rER 0.5) at 18 weeks. Applying novel methodology, we describe detailed cell traffic in vascularized bone transplants, elaborating our comprehension on bone transplantation. Copyright © 2013 Wiley Periodicals, Inc.

  17. Amplatzer vascular plugs in congenital cardiovascular malformations

    Directory of Open Access Journals (Sweden)

    Parag Barwad

    2013-01-01

    Full Text Available Background: Amplatzer vascular plugs (AVPs are devices ideally suited to close medium-to-large vascular communications. There is limited published literature regarding the utility of AVPs in congenital cardiovascular malformations (CCVMs. Aims: To describe the use of AVPs in different CCVMs and to evaluate their safety and efficacy. Materials and Methods: All patients who required an AVP for the closure of CCVM were included in this retrospective review of our catheterization laboratory data. The efficacy and safety of AVPs are reported. Results: A total of 39 AVPs were implanted in 31 patients. Thirteen (33% were AVP type I and 23 (59% were AVP type II. AVP type III were implanted in two patients and type IV in one patient. The major indications for their use included closure of pulmonary arteriovenous malformation (AVM (n = 7, aortopulmonary collaterals (n = 7, closure of a patent Blalock-Taussig shunt (n = 5, systemic AVM (n = 5, coronary AVM (n = 4, patent ductus arteriosus (PDA (n = 3, pulmonary artery aneurysms (n = 3, and venovenous collaterals (n = 2. Deployment of the AVP was done predominantly via the 5 - 7F Judkin′s right coronary guide catheter. Overall 92% of the AVPs could be successfully deployed and resulted in occlusion of the target vessel in all cases, within 10 minutes. No procedure-related or access site complication occurred. Conclusions: AVPs are versatile, easy to use, and effective devices to occlude the vascular communications in a variety of settings. AVP II is especially useful in the closure of tubular structures with a high flow.

  18. Percutaneous Cryotherapy of Vascular Malformation: Initial Experience

    Energy Technology Data Exchange (ETDEWEB)

    Cornelis, F., E-mail: francoiscornelis@hotmail.com [Institut Bergonie, Department of Radiology (France); Neuville, A. [Institut Bergonie, Department of Pathology (France); Labreze, C. [Pellegrin Hospital, Department of Pediatric Dermatology (France); Kind, M. [Institut Bergonie, Department of Radiology (France); Bui, B. [Institut Bergonie, Department of Oncology (France); Midy, D. [Pellegrin Hospital, Department of Vascular Surgery (France); Palussiere, J. [Institut Bergonie, Department of Radiology (France); Grenier, N. [Pellegrin Hospital, Department of Radiology (France)

    2013-06-15

    The present report describes a case of percutaneous cryotherapy in a 36-year-old woman with a large and painful pectoral venous malformation. Cryoablation was performed in a single session for this 9-cm mass with 24 h hospitalisation. At 2- and 6-month follow-up, the pain had completely disappeared, and magnetic resonance imaging demonstrated a significant decrease in size. Percutaneous cryoablation shows promise as a feasible and apparently safe method for local control in patients with symptomatic venous vascular malformations.

  19. The evolving integrated vascular surgery residency curriculum.

    Science.gov (United States)

    Smith, Brigitte K; Greenberg, Jacob A; Mitchell, Erica L

    2014-10-01

    Since their introduction several years ago, integrated (0 + 5) vascular surgery residency programs are being increasingly developed across the country. To date, however, there is no defined "universal" curriculum for these programs and each program is responsible for creating its own curriculum. The aim of this study was to review the experiences of current 0 + 5 program directors (PDs) to determine what factors contributed to the curricular development within their institution. Semistructured interviews were conducted with 0 + 5 PDs to explore their experiences with program development, factors influencing the latter, and rationale for current curricula. The interview script was loosely structured to explore several factors including time of incoming residents' first exposure to the vascular surgical service, timing and rationale behind the timing of core surgical rotations throughout the 5 year program, educational value of nonsurgical rotations, opportunities for leadership and scholarly activity, and influence the general surgery program and institutional climate had on curricular structure. All interviews were conducted by a single interviewer. All interviews were qualitatively analyzed using emergent theme analysis. Twenty-six 0 + 5 PDs participated in the study. A total of 69% believed establishing professional identity early reduces resident attrition and recommend starting incoming trainees on vascular surgical services. Sixty-two percent spread core surgical rotations over the first 3 years to optimize general surgical exposure and most of the programs have eliminated specific rotations, as they were not considered valuable to the goals of training. Factors considered most important by PDs in curricular development include building on existing institutional opportunities (96%), avoiding rotations considered unsuccessful by "experienced" programs (92%), and maintaining a good working relationship with general surgery (77%). Fifty-eight percent of

  20. Percutaneous Cryotherapy of Vascular Malformation: Initial Experience

    International Nuclear Information System (INIS)

    Cornelis, F.; Neuville, A.; Labrèze, C.; Kind, M.; Bui, B.; Midy, D.; Palussière, J.; Grenier, N.

    2013-01-01

    The present report describes a case of percutaneous cryotherapy in a 36-year-old woman with a large and painful pectoral venous malformation. Cryoablation was performed in a single session for this 9-cm mass with 24 h hospitalisation. At 2- and 6-month follow-up, the pain had completely disappeared, and magnetic resonance imaging demonstrated a significant decrease in size. Percutaneous cryoablation shows promise as a feasible and apparently safe method for local control in patients with symptomatic venous vascular malformations.

  1. Vascular access: a never-ending story.

    Science.gov (United States)

    Hedin, U

    2014-12-01

    Vascular surgeons are more and more becoming responsible for "life-line" creation well functioning and maintenance of hemodialysis patients and to provide a well functioning and multidisciplinary access service together with nefrologists, dialysis staff, and interventional radiology. For many, this sometimes arduous surgery with associated complicated clinical decision making, becomes a constant and challenging burden but much through the appearance of national and international guidelines and especially the endovascular technology, feasible solutions are easily at hand and the life as an access surgeon more pleasant. Here, basics in dialysis access care are presented together with some examples of novel available solutions to troublesome clinical problems.

  2. Vascular Plants of the Chimbote Wetlands, Peru

    OpenAIRE

    Arana, César; Salinas, Letty

    2013-01-01

    Los humedales de Chimbote (09°05’51"S; 78°32’52"O) presentan una flora vascular compuesta por 41 especies en 18 familias. El 61% magnoliópsidas y el 39% liliópsidas. Las familias con mayor número de especies fueron Poaceae, Cyperaceae y Asteraceae. Las formas de crecimiento dominantes fueron las hierbas (85%) seguidas de arbustos (10%). En comparación con los humedales costeros de Lima, en Chimbote se presenta mayor riqueza de especies que en Medio Mundo (16 especies) y El Paraíso (25), aunqu...

  3. Contrast-Enhanced Ultrasound in Vascular Surgery

    DEFF Research Database (Denmark)

    Bredahl, Kim; Mestre, Xavier Marti; Coll, Ramon Vila

    2017-01-01

    modalities. Ultrasound has only challenged these methods in assessment of carotid disease, aortic aneurysms, venous insufficiency, and thromboembolism and in surveillance of in situ bypasses. These practice patterns may change with the introduction of second-generation ultrasound contrast agents which...... are easy to use, manageable, and safe. This topical review attempts to summarize and highlight the current evidence and future prospects for contrast-enhanced ultrasound in vascular surgery, with a particular focus on opportunities in carotid and lower limb arteriosclerotic disease and surveillance after...

  4. Abdominal vascular syndromes: characteristic imaging findings

    International Nuclear Information System (INIS)

    Cardarelli-Leite, Leandro; Velloni, Fernanda Garozzo; Salvadori, Priscila Silveira; Lemos, Marcelo Delboni; D'Ippolito, Giuseppe

    2016-01-01

    Abdominal vascular syndromes are rare diseases. Although such syndromes vary widely in terms of symptoms and etiologies, certain imaging findings are characteristic. Depending on their etiology, they can be categorized as congenital - including blue rubber bleb nevus syndrome, Klippel-Trenaunay syndrome, and hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome) - compressive - including 'nutcracker' syndrome, median arcuate ligament syndrome, Cockett syndrome (also known as May-Thurner syndrome), and superior mesenteric artery syndrome. In this article, we aimed to illustrate imaging findings that are characteristic of these syndromes, through studies conducted at our institution, as well as to perform a brief review of the literature on this topic. (author)

  5. Acute cerebral vascular accident associated with hyperperfusion

    International Nuclear Information System (INIS)

    Soin, J.S.; Burdine, J.A.

    1976-01-01

    Cerebral radionuclide angiography can demonstrate decreased or normal radioactivity in the affected region during the arterial phase in patients who have sustained a cerebral vascular accident and thus enhances the diagnostic specificity of the static brain image. In an occasional patient, however, a seemingly paradoxical pattern of regional hyperperfusion with a return to normal or subnormal perfusion following the acute phase has been observed. This phenomenon, called luxury perfusion, has been defined using intra-arterial 133 Xe for semiquantitative cerebral blood flow measurements and should be kept in mind as a potentially misleading cerebral imaging pattern

  6. Abdominal vascular syndromes: characteristic imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Cardarelli-Leite, Leandro; Velloni, Fernanda Garozzo; Salvadori, Priscila Silveira; Lemos, Marcelo Delboni; D' Ippolito, Giuseppe, E-mail: leandrocleite@gmail.com [Universidade Federal de Sao Paulo (EPM/UNIFESP), Sao Paulo, SP (Brazil). Escola Paulista de Mediciana. Departmento de Diagnostico por Imagem

    2016-07-15

    Abdominal vascular syndromes are rare diseases. Although such syndromes vary widely in terms of symptoms and etiologies, certain imaging findings are characteristic. Depending on their etiology, they can be categorized as congenital - including blue rubber bleb nevus syndrome, Klippel-Trenaunay syndrome, and hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome) - compressive - including 'nutcracker' syndrome, median arcuate ligament syndrome, Cockett syndrome (also known as May-Thurner syndrome), and superior mesenteric artery syndrome. In this article, we aimed to illustrate imaging findings that are characteristic of these syndromes, through studies conducted at our institution, as well as to perform a brief review of the literature on this topic. (author)

  7. Cerebral radiation necrosis: vascular and glial features

    Energy Technology Data Exchange (ETDEWEB)

    Husain, M M; Garcia, J H

    1976-12-21

    Glial and vascular abnormalities in brain, simulating intracranial neoplasia, are described in a patient who received radiation to the pituitary region for treatment of an adenoma, 13 months before death. In addition to the expected changes of cerebral radionecrosis, four interesting features are cited: (1) diffuse hyperplasia of capillaries in the cerebral cortex with marked endothelial hypertrophy; (2) abundant, large multipolar bizarre cells in the perivascular connective tissues; (3) focal astrocytic proliferation with many cells resembling either Alzheimer type I astrocytes or neoplastic cells, and (4) radiation changes in the non-irradiated brain.

  8. Dramatic Vascular Course of Behcet's Disease

    International Nuclear Information System (INIS)

    Elsharawy, Mohamed A.; Hassan, Khairi A.; Al-Awami, Majed; Al-Mulhim, Fatma A.

    2004-01-01

    Vascular involvement in Behcet's disease is rare (approximately 14% venous and 1.6% arterial), serious and recurrent. We report a case of Behcet's disease with deep venous thrombosis and right iliac pseudoaneurysm which was repaired with polytetrafluoroethylene (PTFE) graft. The patient received warfarin, aspirin, clopidogrel, immunosupressive and corticosteroids. Two months later the patient developed manifestations of superior vena cava thrombosis and the graft was blocked. Three months later, ischemia of the right foot deteriorated and left femoral artery crossover (PTFE) graft was performed. (author)

  9. Structural and functional imaging for vascular targeted photodynamic therapy

    Science.gov (United States)

    Li, Buhong; Gu, Ying; Wilson, Brian C.

    2017-02-01

    Vascular targeted photodynamic therapy (V-PDT) has been widely used for the prevention or treatment of vascular-related diseases, such as localized prostate cancer, wet age-related macular degeneration, port wine stains, esophageal varices and bleeding gastrointestinal mucosal lesions. In this study, the fundamental mechanisms of vascular responses during and after V-PDT will be introduced. Based on the V-PDT treatment of blood vessels in dorsal skinfold window chamber model, the structural and functional imaging, which including white light microscopy, laser speckle imaging, singlet oxygen luminescence imaging, and fluorescence imaging for evaluating vascular damage will be presented, respectively. The results indicate that vessel constriction and blood flow dynamics could be considered as the crucial biomarkers for quantitative evaluation of vascular damage. In addition, future perspectives of non-invasive optical imaging for evaluating vascular damage of V-PDT will be discussed.

  10. Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells

    Directory of Open Access Journals (Sweden)

    Jie Su

    2015-01-01

    Full Text Available Objectives. Preliminary researches showed that luteolin was used to treat hypertension. However, it is still unclear whether luteolin has effect on the hypertensive complication such as vascular remodeling. The present study was designed to investigate the effect of luteolin on the hypertensive vascular remodeling and its molecular mechanism. Method and Results. We evaluated the effect of luteolin on aorta thickening of hypertension in spontaneous hypertensive rats (SHRs and found that luteolin could significantly decrease the blood pressure and media thickness of aorta in vivo. Luteolin could inhibit angiotensin II- (Ang II- induced proliferation and migration of vascular smooth muscle cells (VSMCs. Dichlorofluorescein diacetate (DCFH-DA staining result showed that luteolin reduced Ang II-stimulated ROS production in VSMCs. Furthermore, western blot and gelatin zymography results showed that luteolin treatment leaded to a decrease in ERK1/2, p-ERK1/2, p-p38, MMP2, and proliferating cell nuclear antigen (PCNA protein level. Conclusion. These data support that luteolin can ameliorate hypertensive vascular remodeling by inhibiting the proliferation and migration of Ang II-induced VSMCs. Its mechanism is mediated by the regulation of MAPK signaling pathway and the production of ROS.

  11. HMGB1 in vascular diseases : Its role in vascular inflammation and atherosclerosis

    NARCIS (Netherlands)

    de Souza, A. W. S.; Westra, J.; Limburg, P. C.; Bijl, M.; Kallenberg, C. G. M.

    2012-01-01

    The nuclear protein high mobility group box 1 (HMGB1) has been suggested to be involved in the pathogenesis of several vascular diseases such as systemic vasculitis and atherosclerosis. In systemic vasculitides including ANCA-associated vasculitis and Kawasaki disease, serum HMGB1 levels are higher

  12. New aspects of vascular remodelling: the involvement of all vascular cell types.

    Science.gov (United States)

    McGrath, John C; Deighan, Clare; Briones, Ana M; Shafaroudi, Majid Malekzadeh; McBride, Melissa; Adler, Jeremy; Arribas, Silvia M; Vila, Elisabet; Daly, Craig J

    2005-07-01

    Conventionally, the architecture of arteries is based around the close-packed smooth muscle cells and extracellular matrix. However, the adventitia and endothelium are now viewed as key players in vascular growth and repair. A new dynamic picture has emerged of blood vessels in a constant state of self-maintenance. Recent work raises fundamental questions about the cellular heterogeneity of arteries and the time course and triggering of normal and pathological remodelling. A common denominator emerging in hypertensive remodelling is an early increase in adventitial cell density suggesting that adventitial cells drive remodelling and may initiate subsequent changes such as re-arrangement of smooth muscle cells and extracellular matrix. The organization of vascular smooth muscle cells follows regular arrangements that can be modelled mathematically. In hypertension, new patterns can be quantified in these terms and give insights to how structure affects function. As with smooth muscle, little is known about the organization of the vascular endothelium, or its role in vascular remodelling. Current observations suggest that there may be a close relationship between the helical organization of smooth muscle cells and the underlying pattern of endothelial cells. The function of myoendothelial connections is a topic of great current interest and may relate to the structure of the internal elastic lamina through which the connections must pass. In hypertensive remodelling this must present an organizational challenge. The objective of this paper is to show how the functions of blood vessels depend on their architecture and a continuous interaction of different cell types and extracellular proteins.

  13. Vascular complications of prosthetic inter-vertebral discs

    OpenAIRE

    Daly, Kevin J.; Ross, E. Raymond S.; Norris, Heather; McCollum, Charles N.

    2006-01-01

    Five consecutive cases of prosthetic inter-vertebral disc displacement with severe vascular complications on revisional surgery are described. The objective of this case report is to warn spinal surgeons that major vascular complications are likely with anterior displacement of inter-vertebral discs. We have not been able to find a previous report on vascular complications associated with anterior displacement of prosthetic inter-vertebral discs. In all five patients the prosthetic disc had e...

  14. Brain Arterial Diameters as a Risk Factor for Vascular Events.

    Science.gov (United States)

    Gutierrez, Jose; Cheung, Ken; Bagci, Ahmet; Rundek, Tatjana; Alperin, Noam; Sacco, Ralph L; Wright, Clinton B; Elkind, Mitchell S V

    2015-08-06

    Arterial luminal diameters are routinely used to assess for vascular disease. Although small diameters are typically considered pathological, arterial dilatation has also been associated with disease. We hypothesize that extreme arterial diameters are biomarkers of the risk of vascular events. Participants in the Northern Manhattan Study who had a time-of-flight magnetic resonance angiography were included in this analysis (N=1034). A global arterial Z-score, called the brain arterial remodeling (BAR) score, was obtained by averaging the measured diameters within each individual. Individuals with a BAR score -2 and 2 SDs had the largest diameters. All vascular events were recorded prospectively after the brain magnetic resonance imaging. Spline curves and incidence rates were used to test our hypothesis. The association of the BAR score with death (P=0.001), vascular death (P=0.02), any vascular event (P=0.05), and myocardial infarction (P=0.10) was U-shaped except for ischemic stroke (P=0.74). Consequently, incidence rates for death, vascular death, myocardial infarction, and any vascular event were higher in individuals with the largest diameters, whereas individuals with the smallest diameters had a higher incidence of death, vascular death, any vascular event, and ischemic stroke compared with individuals with average diameters. The risk of death, vascular death, and any vascular event increased at both extremes of brain arterial diameters. The pathophysiology linking brain arterial remodeling to systemic vascular events needs further research. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  15. 3D-Printed Biodegradable Polymeric Vascular Grafts.

    Science.gov (United States)

    Melchiorri, A J; Hibino, N; Best, C A; Yi, T; Lee, Y U; Kraynak, C A; Kimerer, L K; Krieger, A; Kim, P; Breuer, C K; Fisher, J P

    2016-02-04

    Congenital heart defect interventions may benefit from the fabrication of patient-specific vascular grafts because of the wide array of anatomies present in children with cardiovascular defects. 3D printing is used to establish a platform for the production of custom vascular grafts, which are biodegradable, mechanically compatible with vascular tissues, and support neotissue formation and growth. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Pathophysiology of Headaches with a Prominent Vascular Component

    Directory of Open Access Journals (Sweden)

    Juan A Pareja

    1996-01-01

    Full Text Available Vascular changes, whether preliminary or secondary, seem to accompany most headaches. The literature concerning pathophysiological mechanisms in headaches where vascular phenomena are a major, integral part, ie, migraine and cluster headache syndrome, is reviewed and the most common forms of headache associated with cerebrovascular disease are discussed. Emphasis is placed on the vascular phenomena and on the abundant hypotheses and theories regarding headache mechanisms. This review also presents alternative explanatory models, and compares the available anatomical, physiological and biochemical results.

  17. Vascular hemichorea: case report and review

    Directory of Open Access Journals (Sweden)

    Bárbara Martínez Alfonzo

    2014-04-01

    Full Text Available Chorea rarely complicates ischemic or hemorrhagic cerebral vascular lesions. Clinical symptoms usually involve one side of the body while the injury is situated on the contralateral cerebral hemisphere. Spontaneous remission is the norm, but sometimes symptomatic treatment is required. A 58-year-old male patient who suffers from untreated high blood pressure, type II obesity, smokes 6 packs of cigarettes per year and has a moderate intake of alcohol is presented. The patient’s recent history began three days before he appeared at the Emergency Department. His symptoms were ceaseless, involuntary movements in his left arm and foot during day and night with no restriction of voluntary movements. Physical examination and laboratory tests revealed no other findings. Magnetic resonance imaging of the brain showed hyperintensity in the right posterolateral thalamic region consistent with ischemic cerebrovascular disease. Symptomatic therapy was indicated and his underlying conditions were addressed. The importance of this case lies on the low prevalence as well as the scarcity of publications regarding vascular causes of hemichorea, including diagnosis, therapy and prognosis.

  18. Connections matter: channeled hydrogels to improve vascularization

    Directory of Open Access Journals (Sweden)

    Severin eMuehleder

    2014-11-01

    Full Text Available The use of cell-laden hydrogels to engineer soft tissue has been emerging within the past years. Despite several newly developed and sophisticated techniques to encapsulate different cell types the importance of vascularization of the engineered constructs is often underestimated. As a result, cell death within a construct leads to impaired function and inclusion of the implant. Here, we discuss the fabrication of hollow channels within hydrogels as a promising strategy to facilitate vascularization. Furthermore, we present an overview on the feasible use of removable spacers, 3D laser- and planar processing strategies to create channels within hydrogels. The implementation of these structures promotes control over cell distribution and increases oxygen transport and nutrient supply in vitro. However, many studies lack the use of endothelial cells in their approaches leaving out an important factor to enhance vessel ingrowth and anastomosis formation upon implantation. In addition, the adequate endothelial cell type needs to be considered to make these approaches bridge the gap to in vivo applications.

  19. Connections matter: channeled hydrogels to improve vascularization.

    Science.gov (United States)

    Muehleder, Severin; Ovsianikov, Aleksandr; Zipperle, Johannes; Redl, Heinz; Holnthoner, Wolfgang

    2014-01-01

    The use of cell-laden hydrogels to engineer soft tissue has been emerging within the past years. Despite, several newly developed and sophisticated techniques to encapsulate different cell types the importance of vascularization of the engineered constructs is often underestimated. As a result, cell death within a construct leads to impaired function and inclusion of the implant. Here, we discuss the fabrication of hollow channels within hydrogels as a promising strategy to facilitate vascularization. Furthermore, we present an overview on the feasible use of removable spacers, 3D laser-, and planar processing strategies to create channels within hydrogels. The implementation of these structures promotes control over cell distribution and increases oxygen transport and nutrient supply in vitro. However, many studies lack the use of endothelial cells in their approaches leaving out an important factor to enhance vessel ingrowth and anastomosis formation upon implantation. In addition, the adequate endothelial cell type needs to be considered to make these approaches bridge the gap to in vivo applications.

  20. Maintenance of vascular access patency in pediatrics

    International Nuclear Information System (INIS)

    Hoffer, F.A.; Wyly, J.B.; Fellows, K.E.; Harmon, W.; Levey, R.H.

    1986-01-01

    The patency of vascular access shunts and fistulae has been prolonged by a combined surgical and radiological approach that includes percutaneous transluminal angioplasty (PTA), surgical revision, thrombectomy, and thrombolysis. Over the last 3 years, 35 vascular accesses in 27 patients were found to have angiographic abnormality. PTA was performed 32 times of 19 accesses and 7 PTAs resulted in patent accesses by the end of the study. Surgical revision was performed 9 times on 8 accesses and 2 of the surgical revisions resulted in a patent access by the end of the study. Concerning Thomas femoral shunts, PTA prolonged the patency by 2.2 months and surgical revision by 3.8 months per procedure. Concerning arteriovenous (AV) fistulae, PTA prolonged the patency by 4.3 months and surgical revision by 3.5 months per procedure. A combination of procedures effectively doubles the duration of patency of Thomas femoral shunts and almost triples the duration of patency of AV fistulae in children. Forty-one percent of these accesses remain open 1 year following the initiation of these procedures. (orig.)