A new frequency-domain criterion for elimination of limit cycles in fixed-point state-space digital filters using saturation arithmetic

International Nuclear Information System (INIS)

Singh, Vimal

2007-01-01

In [Singh V. Elimination of overflow oscillations in fixed-point state-space digital filters using saturation arithmetic. IEEE Trans Circ Syst 1990;37(6):814-8], a frequency-domain criterion for the suppression of limit cycles in fixed-point state-space digital filters using saturation overflow arithmetic was presented. The passivity property owing to the presence of multiple saturation nonlinearities was exploited therein. In the present paper, a new notion of passivity, namely, that involving the state variables is considered, thereby arriving at an entirely new frequency-domain criterion for the suppression of limit cycles in such filters

Cosmiclike domain walls in superfluid 3He-B: Instantons and diabolical points in (k,r) space

International Nuclear Information System (INIS)

Salomaa, M.M.; Volovik, G.E.

1988-01-01

The possible planar superfluid B-B boundaries between inequivalent B-phase vacua are considered; such B-B interfaces provide an analogy with the cosmic domain walls that are believed to have precipitated in the phase transitions of the early Universe. Several of them display nontrivial structure in (k,r) space (i.e., the union of the momentum and real spaces). Such a wall represents an instanton connecting two B-phase vacua with different k-space topology. The transition between the vacua occurs through the formation of a pointlike defect either in the (k,r) space, or in the (k,t) space. These defects are so-called diabolical points of codimension 4, at which the fermionic energy tends to zero, thus providing the fermionic zero modes. Such points are new examples (within condensed-matter physics) of the peculiar diabolical points, which are characterized by the occurrence of a contact between the different branches of the quasiparticle spectra; in the present case, the branches of particles and holes, respectively. These points are here discussed for the case of the superfluid phases of liquid 3 He in close analogy with the quantum field theory of fermions interacting with classical bosonic fields. The cosmiclike domain walls in superfluid 3 He-B are observable in principle; in particular, the motion of the superfluid A-B interface is governed at low temperatures by the periodical emission of these topological excitation planes

Integrated performance of a frequency domain multiplexing readout in the SPT-3G receiver

Science.gov (United States)

Bender, A. N.; Ade, P. A. R.; Anderson, A. J.; Avva, J.; Ahmed, Z.; Arnold, K.; Austermann, J. E.; Basu Thakur, R.; Benson, B. A.; Bleem, L. E.; Byrum, K.; Carlstrom, J. E.; Carter, F. W.; Chang, C. L.; Cho, H. M.; Cliche, J. F.; Crawford, T. M.; Cukierman, A.; Czaplewski, D. A.; Ding, J.; Divan, R.; de Haan, T.; Dobbs, M. A.; Dutcher, D.; Everett, W.; Gilbert, A.; Groh, J. C.; Guyser, R.; Halverson, N. W.; Harke-Hosemann, A.; Harrington, N. L.; Hattori, K.; Henning, J. W.; Hilton, G. C.; Holzapfel, W. L.; Huang, N.; Irwin, K. D.; Jeong, O.; Khaire, T.; Korman, M.; Kubik, D.; Kuo, C. L.; Lee, A. T.; Leitch, E. M.; Lendinez, S.; Meyer, S. S.; Miller, C. S.; Montgomery, J.; Nadolski, A.; Natoli, T.; Nguyen, H.; Novosad, V.; Padin, S.; Pan, Z.; Pearson, J.; Posada, C. M.; Rahlin, A.; Reichardt, C. L.; Ruhl, J. E.; Saliwanchik, B. R.; Sayre, J. T.; Shariff, J. A.; Shirley, Ian; Shirokoff, E.; Smecher, G.; Sobrin, J.; Stan, L.; Stark, A. A.; Story, K.; Suzuki, A.; Tang, Q. Y.; Thompson, K. L.; Tucker, C.; Vanderlinde, K.; Vieira, J. D.; Wang, G.; Whitehorn, N.; Yefremenko, V.; Yoon, K. W.

2016-07-01

The third generation receiver for the South Pole Telescope, SPT-3G, will make extremely deep, arcminuteresolution maps of the temperature and polarization of the cosmic microwave background. The SPT-3G maps will enable studies of the B-mode polarization signature, constraining primordial gravitational waves as well as the effect of massive neutrinos on structure formation in the late universe. The SPT-3G receiver will achieve exceptional sensitivity through a focal plane of 16,000 transition-edge sensor bolometers, an order of magnitude more than the current SPTpol receiver. SPT-3G uses a frequency domain multiplexing (fMux) scheme to read out the focal plane, combining the signals from 64 bolometers onto a single pair of wires. The fMux readout facilitates the large number of detectors in the SPT-3G focal plane by limiting the thermal load due to readout wiring on the 250 millikelvin cryogenic stage. A second advantage of the fMux system is that the operation of each bolometer can be optimized. In addition to these benefits, the fMux readout introduces new challenges into the design and operation of the receiver. The bolometers are operated at a range of frequencies up to 5 MHz, requiring control of stray reactances over a large bandwidth. Additionally, crosstalk between multiplexed detectors will inject large false signals into the data if not adequately mitigated. SPT-3G is scheduled to deploy to the South Pole Telescope in late 2016. Here, we present the pre-deployment performance of the fMux readout system with the SPT-3G focal plane.

Structural studies of the activation of the two component receiver domain NTRC by multidimensional heteronuclear NMR

Energy Technology Data Exchange (ETDEWEB)

Nohaile, Michael James [Univ. of California, Berkeley, CA (United States). Dept. of Chemistry

1996-05-01

Multidimensional heteronuclear NMR spectroscopy was used to investigate the N-terminal domain of the transcriptional enhancer NTRC (NiTrogen Regulatory protein C). This domain belongs to the family of receiver domains of two-component regulatory systems involved in signal transduction. Phosphorylation of NTRC at D54 leads to an activated form of the molecule which stimulates transcription of genes involved in nitrogen regulation. Three and four dimensional NMR techniques were used to determine an intermediate resolution structure of the unphosphorylated, inactive form of the N-terminal domain of NTRC. The structure is comprised of five α-helices and a five-stranded β-sheet in a (β/α)₅ topology. Analysis of the backbone dynamics of NTRC indicate that helix 4 and strand 5 are significantly more flexible than the rest of the secondary structure of the protein and that the loops making up the active site are flexible. The short lifetime of phospho-NTRC hampers the study of this form. However, conditions for determining the resonance assignments and, possibly, the three dimensional structure of phosphorylated NTRC have been obtained. Tentative assignments of the phosphorylated form indicate that the majority of the changes that NTRC experiences upon phosphorylation occur in helix 3, strand 4, helix 4, strand 5, and the loop between strand 5 and helix 5 (the 3445 face of NTRC) as well as near the site of phosphorylation. In order to examine a stable, activated form of the protein, constitutively active mutants of NTRC were investigated.

Structural modeling of the N-terminal signal–receiving domain of IκBα

Directory of Open Access Journals (Sweden)

Samira eYazdi

2015-06-01

Full Text Available The transcription factor nuclear factor-κB (NF-κB exerts essential roles in many biological processes including cell growth, apoptosis and innate and adaptive immunity. The NF-kB inhibitor (IκBα retains NF-κB in the cytoplasm and thus inhibits nuclear localization of NF-κB and its association with DNA. Recent protein crystal structures of the C-terminal part of IκBα in complex with NF-κB provided insights into the protein-protein interactions but could not reveal structural details about the N-terminal signal receiving domain (SRD. The SRD of IκBα contains a degron, formed following phosphorylation by IκB kinases (IKK. In current protein X-ray structures, however, the SRD is not resolved and assumed to be disordered. Here, we combined secondary structure annotation and domain threading followed by long molecular dynamics (MD simulations and showed that the SRD possesses well-defined secondary structure elements. We show that the SRD contains 3 additional stable α-helices supplementing the six ARDs present in crystallized IκBα. The IκBα/NF-κB protein-protein complex remained intact and stable during the entire simulations. Also in solution, free IκBα retains its structural integrity. Differences in structural topology and dynamics were observed by comparing the structures of NF-κB free and NF-κB bound IκBα-complex. This study paves the way for investigating the signaling properties of the SRD in the IκBα degron. A detailed atomic scale understanding of molecular mechanism of NF-κB activation, regulation and the protein-protein interactions may assist to design and develop novel chronic inflammation modulators.

A time domain inverse dynamic method for the end point tracking control of a flexible manipulator

Science.gov (United States)

Kwon, Dong-Soo; Book, Wayne J.

1991-01-01

The inverse dynamic equation of a flexible manipulator was solved in the time domain. By dividing the inverse system equation into the causal part and the anticausal part, we calculated the torque and the trajectories of all state variables for a given end point trajectory. The interpretation of this method in the frequency domain was explained in detail using the two-sided Laplace transform and the convolution integral. The open loop control of the inverse dynamic method shows an excellent result in simulation. For real applications, a practical control strategy is proposed by adding a feedback tracking control loop to the inverse dynamic feedforward control, and its good experimental performance is presented.

Measurements of the Received Signal Level and Service Coverage Area at the IEEE 802.11 Access Point in the Building

Science.gov (United States)

Gunantara, N.; Sudiarta, P. K.; Prasetya, AAN A. I.; Dharma, A.; Gde Antara, I. N.

2018-04-01

Access point (AP) is part of a Wireless Local Access Network (WLAN) with its communications using WiFi. AP is used to transmit and receive data to users/clients. The ability of AP to serve users/clients depends on many factors. Moreover, if AP is applied in conditions inside the building. In this study, AP is installed at two points inside the building and then measured in the form of the received signal level (RSL) and service coverage area. One AP measured its performance by 26 measurement points and the other AP measured its performance by 20 measurement points. When AP has measured its performance then another AP position is switched off. Based on the measurement result, the received signal level value is the highest value is about -47 dBm at a distance of 3.2 m, while the lowest is about -79 dBm at a 9.21 m because it is on barrier 2 walls. While based on service coverage area, the area which is far away from the AP then the quality of service becomes bad because the transmitted signal is weakening caused by the distance and the loss of the wall.

Evaluation of magnetic helicity density in the wave number domain using multi-point measurements in space

Directory of Open Access Journals (Sweden)

Y. Narita

2009-10-01

Full Text Available We develop an estimator for the magnetic helicity density, a measure of the spiral geometry of magnetic field lines, in the wave number domain as a wave diagnostic tool based on multi-point measurements in space. The estimator is numerically tested with a synthetic data set and then applied to an observation of magnetic field fluctuations in the Earth foreshock region provided by the four-point measurements of the Cluster spacecraft. The energy and the magnetic helicity density are determined in the frequency and the wave number domain, which allows us to identify the wave properties in the plasma rest frame correcting for the Doppler shift. In the analyzed time interval, dominant wave components have parallel propagation to the mean magnetic field, away from the shock at about Alfvén speed and a left-hand spatial rotation sense of helicity with respect to the propagation direction, which means a right-hand temporal rotation sense of polarization. These wave properties are well explained by the right-hand resonant beam instability as the driving mechanism in the foreshock. Cluster observations allow therefore detailed comparisons with various theories of waves and instabilities.

Resource Unavailability (RU) Per Domain Behavior

NARCIS (Netherlands)

Karagiannis, Georgios; Westberg, L.; Bader, A.; Tschofenig, Hannes; Tschofenig, H.

2006-01-01

This draft specifies a Per Domain Behavior that provides the ability to Diffserv nodes located outside Diffserv domain(s), e.g., receiver or other Diffserv enabled router to detect when the resources provided by the Diffserv domain(s) are not available. The unavailability of resources in the domain

Domain-specific languages in perspective

NARCIS (Netherlands)

J. Heering (Jan); M. Mernik (Marjan)

2007-01-01

textabstractDomain-specific languages (DSLs) are languages tailored to a specific application domain. They offer substantial gains in expressiveness and ease of use compared with general-purpose languages in their domain of application. Although the use of DSLs is by no means new, it is receiving

Digital processing optical transmission and coherent receiving techniques

CERN Document Server

Binh, Le Nguyen

2013-01-01

With coherent mixing in the optical domain and processing in the digital domain, advanced receiving techniques employing ultra-high speed sampling rates have progressed tremendously over the last few years. These advances have brought coherent reception systems for lightwave-carried information to the next stage, resulting in ultra-high capacity global internetworking. Digital Processing: Optical Transmission and Coherent Receiving Techniques describes modern coherent receiving techniques for optical transmission and aspects of modern digital optical communications in the most basic lines. The

Studies on scaling of flow noise received at the stagnation point of an axisymmetric body

Science.gov (United States)

Arakeri, V. H.; Satyanarayana, S. G.; Mani, K.; Sharma, S. D.

1991-05-01

A description of the studies related to the problem of scaling of flow noise received at the stagnation point of axisymmetric bodies is provided. The source of flow noise under consideration is the transitional/turbulent regions of the boundary layer flow on the axisymmetric body. Lauchle has recently shown that the noise measured in the laminar region (including the stagnation point) corresponds closely to the noise measured in the transition region, provided that the acoustic losses due to diffraction are accounted for. The present study includes experimental measurement of flow noise at the stagnation point of three different shaped axisymmetric headforms. One of the body shapes chosen is that used by Lauchle in similar studies. This was done to establish the effect of body size on flow noise. The results of the experimental investigations clearly show that the flow noise received at the stagnation point is a strong function of free stream velocity, a moderately strong function of body scale but a weak function of boundary layer thickness. In addition, there is evidence that when body scale change is involved, flow noise amplitude scales but no frequency shift is involved. A scaling procedure is proposed based on the present observations along with those of Lauchle. At a given frequency, the amplitude of noise level obtained under model testing conditions is first scaled to account for differences in the velocity and size corresponding to the prototype conditions; then a correction to this is applied to account for losses due to diffraction, which are estimated on the basis of the geometric theory of diffraction (GTD) with the source being located at the predicted position of turbulent transition. Use of the proposed scaling law to extrapolate presently obtained noise levels to two other conditions involving larger-scale bodies show good agreement with actually measured levels, in particular at higher frequencies. Since model scale results have been used

An ontological approach to domain engineering

NARCIS (Netherlands)

Falbo, R.A.; Guizzardi, G.; Duarte, K.

2002-01-01

Domain engineering aims to support systematic reuse, focusing on modeling common knowledge in a problem domain. Ontologies have also been pointed as holding great promise for software reuse. In this paper, we present ODE (Ontology-based Domain Engineering), an ontological approach for domain

Antibodies against CKI1(RD), a receiver domain of the sensor histidine kinase in Arabidopsis thaliana: From antigen preparation to in planta immunolocalization

Czech Academy of Sciences Publication Activity Database

Borkovcová, P.; Pekárová, B.; Válková, M.; Dopitová, R.; Brzobohatý, Břetislav; Janda, L.; Hejatko, J.

2014-01-01

Roč. 100, APR 2014 (2014), s. 6-15 ISSN 0031-9422 R&D Projects: GA MŠk(CZ) ED1.1.00/02.0068 Grant - others:GA ČR(CZ) GAP501/11/1150; GA ČR(CZ) GA13-25280S Program:GA; GA Institutional support: RVO:68081707 Keywords : Receiver domain * Polyclonal antibodies * Immunoprecipitation Subject RIV: BO - Biophysics Impact factor: 2.547, year: 2014

Terahertz time-domain spectroscopy of edible oils

Science.gov (United States)

Dinovitser, Alex; Valchev, Dimitar G.; Abbott, Derek

2017-06-01

Chemical degradation of edible oils has been studied using conventional spectroscopic methods spanning the spectrum from ultraviolet to mid-IR. However, the possibility of morphological changes of oil molecules that can be detected at terahertz frequencies is beginning to receive some attention. Furthermore, the rapidly decreasing cost of this technology and its capability for convenient, in situ measurement of material properties, raises the possibility of monitoring oil during cooking and processing at production facilities, and more generally within the food industry. In this paper, we test the hypothesis that oil undergoes chemical and physical changes when heated above the smoke point, which can be detected in the 0.05-2 THz spectral range, measured using the conventional terahertz time-domain spectroscopy technique. The measurements demonstrate a null result in that there is no significant change in the spectra of terahertz optical parameters after heating above the smoke point for 5 min.

Thermal Power Systems, Point-Focusing Distributed Receiver Technology Project. Annual technical report, Fiscal Year 1978. Volume II. Detailed report

Energy Technology Data Exchange (ETDEWEB)

1979-03-15

Thermal or electrical power from the sun's radiated energy through Point-Focusing Distributed Receiver technology is the goal of this Project. The energy thus produced must be economically competitive with other sources. This Project supports the industrial development of technology and hardware for extracting energy from solar power to achieve the stated goal. Present studies are working to concentrate the solar energy through mirrors or lenses, to a working fluid or gas, and through a power converter change it to an energy source useful to man. Rankine-cycle and Brayton-cycle engines are currently being developed as the most promising energy converters for our near future needs. Accomplishments on point-focusing technology in FY 1978 are detailed.

Domain Specificity between Peer Support and Self-Concept

Science.gov (United States)

Leung, Kim Chau; Marsh, Herbert W.; Craven, Rhonda G.; Yeung, Alexander S.; Abduljabbar, Adel S.

2013-01-01

Peer support interventions have mostly neglected the domain specificity of intervention effects. In two studies, the present investigation examined the domain specificity of peer support interventions targeting specific domains of self-concept. In Study 1, participants ("n" = 50) who had received an academically oriented peer support…

Terahertz time domain interferometry of a SIS tunnel junction and a quantum point contact

Energy Technology Data Exchange (ETDEWEB)

Karadi, Chandu [Univ. of California, Berkeley, CA (United States). Dept. of Physics

1995-09-01

The author has applied the Terahertz Time Domain Interferometric (THz-TDI) technique to probe the ultrafast dynamic response of a Superconducting-Insulating-Superconducting (SIS) tunnel junction and a Quantum Point Contact (QPC). The THz-TDI technique involves monitoring changes in the dc current induced by interfering two picosecond electrical pulses on the junction as a function of time delay between them. Measurements of the response of the Nb/AlO_xNb SIS tunnel junction from 75--200 GHz are in full agreement with the linear theory for photon-assisted tunneling. Likewise, measurements of the induced current in a QPC as a function of source-drain voltage, gate voltage, frequency, and magnetic field also show strong evidence for photon-assisted transport. These experiments together demonstrate the general applicability of the THz-TDI technique to the characterization of the dynamic response of any micron or nanometer scale device that exhibits a non-linear I-V characteristic.

Terahertz time domain interferometry of a SIS tunnel junction and a quantum point contact

International Nuclear Information System (INIS)

Karadi, C.; Lawrence Berkeley Lab., CA

1995-09-01

The author has applied the Terahertz Time Domain Interferometric (THz-TDI) technique to probe the ultrafast dynamic response of a Superconducting-Insulating-Superconducting (SIS) tunnel junction and a Quantum Point Contact (QPC). The THz-TDI technique involves monitoring changes in the dc current induced by interfering two picosecond electrical pulses on the junction as a function of time delay between them. Measurements of the response of the Nb/AlO x /Nb SIS tunnel junction from 75--200 GHz are in full agreement with the linear theory for photon-assisted tunneling. Likewise, measurements of the induced current in a QPC as a function of source-drain voltage, gate voltage, frequency, and magnetic field also show strong evidence for photon-assisted transport. These experiments together demonstrate the general applicability of the THz-TDI technique to the characterization of the dynamic response of any micron or nanometer scale device that exhibits a non-linear I-V characteristic. 133 refs., 49 figs

Receiver Operating Characteristic (ROC to Determine Cut-Off Points of Biomarkers in Lung Cancer Patients

Directory of Open Access Journals (Sweden)

Heidi L. Weiss

2004-01-01

Full Text Available The role of biomarkers in disease prognosis continues to be an important investigation in many cancer studies. In order for these biomarkers to have practical application in clinical decision making regarding patient treatment and follow-up, it is common to dichotomize patients into those with low vs. high expression levels. In this study, receiver operating characteristic (ROC curves, area under the curve (AUC of the ROC, sensitivity, specificity, as well as likelihood ratios were calculated to determine levels of growth factor biomarkers that best differentiate lung cancer cases versus control subjects. Selected cut-off points for p185erbB-2 and EGFR membrane appear to have good discriminating power to differentiate control tissues versus uninvolved tissues from patients with lung cancer (AUC = 89% and 90%, respectively; while AUC increased to at least 90% for selected cut-off points for p185erbB-2 membrane, EGFR membrane, and FASE when comparing between control versus carcinoma tissues from lung cancer cases. Using data from control subjects compared to patients with lung cancer, we presented a simple and intuitive approach to determine dichotomized levels of biomarkers and validated the value of these biomarkers as surrogate endpoints for cancer outcome.

Asymptotic behaviour of solutions of the first boundary-value problem for strongly hyperbolic systems near a conical point at the boundary of the domain

International Nuclear Information System (INIS)

Hung, Nguyen M

1999-01-01

An existence and uniqueness theorem for generalized solutions of the first initial-boundary-value problem for strongly hyperbolic systems in bounded domains is established. The question of estimates in Sobolev spaces of the derivatives with respect to time of the generalized solution is discussed. It is shown that the smoothness of generalized solutions with respect to time is independent of the structure of the boundary of the domain but depends on the coefficients of the right-hand side. Results on the smoothness of the generalized solution and its asymptotic behaviour in a neighbourhood of a conical boundary point are also obtained

Comprehensive Interpretation of a Three-Point Gauss Quadrature with Variable Sampling Points and Its Application to Integration for Discrete Data

Directory of Open Access Journals (Sweden)

Young-Doo Kwon

2013-01-01

Full Text Available This study examined the characteristics of a variable three-point Gauss quadrature using a variable set of weighting factors and corresponding optimal sampling points. The major findings were as follows. The one-point, two-point, and three-point Gauss quadratures that adopt the Legendre sampling points and the well-known Simpson’s 1/3 rule were found to be special cases of the variable three-point Gauss quadrature. In addition, the three-point Gauss quadrature may have out-of-domain sampling points beyond the domain end points. By applying the quadratically extrapolated integrals and nonlinearity index, the accuracy of the integration could be increased significantly for evenly acquired data, which is popular with modern sophisticated digital data acquisition systems, without using higher-order extrapolation polynomials.

Receiver function estimated by maximum entropy deconvolution

Institute of Scientific and Technical Information of China (English)

吴庆举; 田小波; 张乃铃; 李卫平; 曾融生

2003-01-01

Maximum entropy deconvolution is presented to estimate receiver function, with the maximum entropy as the rule to determine auto-correlation and cross-correlation functions. The Toeplitz equation and Levinson algorithm are used to calculate the iterative formula of error-predicting filter, and receiver function is then estimated. During extrapolation, reflective coefficient is always less than 1, which keeps maximum entropy deconvolution stable. The maximum entropy of the data outside window increases the resolution of receiver function. Both synthetic and real seismograms show that maximum entropy deconvolution is an effective method to measure receiver function in time-domain.

Glycogen synthase kinase 3-{beta} phosphorylates novel S/T-P-S/T domains in Notch1 intracellular domain and induces its nuclear localization

Energy Technology Data Exchange (ETDEWEB)

Han, Xiangzi [Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 133-791 (Korea, Republic of); Department of Preventive Medicine, Yanbian University College of Medicine, Yanji (China); Ju, Ji-hyun [Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 133-791 (Korea, Republic of); Shin, Incheol, E-mail: incheol@hanyang.ac.kr [Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 133-791 (Korea, Republic of)

2012-06-29

Highlights: Black-Right-Pointing-Pointer Novel S/T-P-S/T domains were identified in NICD. Black-Right-Pointing-Pointer Phosphorylation of NICD on the S/T-P-S/T domains induced nuclear localization. Black-Right-Pointing-Pointer GSK-3{beta} phosphorylated S and T residues in NICD S/T-P-S/T domains. -- Abstract: We identified two S/T-P-S/T domains (2122-2124, 2126-2128) inducing Notch intracellular domain (NICD) nuclear localization. The GFP-NICD (1963-2145) fusion protein deletion mutant without classical NLS was localized in the nucleus like the full length GFP-NICD. However, quadruple substitution mutant (T2122A T2124A S2126A T2128A) showed increased cytoplasmic localization. GSK-3{beta} enhanced nuclear localization and transcriptional activity of WT NICD but not of quadruple substitution mutant. In vitro kinase assays revealed that GSK-3{beta} phosphorylated S and T residues in NICD S/T-P-S/T domains. These results suggest that the novel S/T-P-S/T domain, phosphorylated by GSK-3{beta} is also involved in the nuclear localization of NICD as well as classical NLS.

Cumulative effective radiation dose received by blunt trauma patients arriving to a military level I trauma center from point of injury and interhospital transfers.

Science.gov (United States)

Van Arnem, Kerri A; Supinski, David P; Tucker, Jonathan E; Varney, Shawn

2016-12-01

Trauma patients sustaining blunt injuries are exposed to multiple radiologic studies. Evidence indicates that the risk of cancer from exposure to ionizing radiation rises in direct proportion to the cumulative effective dose (CED) received. The purpose of this study is to quantify the amount of ionizing radiation accumulated when arriving directly from point of injury to San Antonio Military Medical Center (SAMMC), a level I trauma center, compared with those transferred from other facilities. A retrospective record review was conducted from 1st January 2010 through 31st December 2012. The SAMMC trauma registry, electronic medical records, and the digital radiology imaging system were searched for possible candidates. The medical records were then analyzed for sex, age, mechanism of injury, received directly from point of injury (direct group), transfer from another medical facility (transfer group), computed tomographic scans received, dose-length product, CED of radiation, and injury severity score. A diagnostic imaging physicist then calculated the estimated CED each subject received based on the dose-length product of each computed tomographic scan. A total of 300 patients were analyzed, with 150 patients in the direct group and 150 patients in the transfer group. Both groups were similar in age and sex. Patients in the transfer group received a significantly greater CED of radiation compared with the direct group (mean, 37.6 mSv vs 28 mSv; P=.001). The radiation received in the direct group correlates with a lifetime attributable risk (LAR) of 1 in 357 compared with the transfer group with an increase in LAR to 1 in 266. Patients transferred to our facility received a 34% increase in ionizing radiation compared with patients brought directly from the injury scene. This increased dose of ionizing radiation contributes to the LAR of cancer and needs to be considered before repeating imaging studies. III. Published by Elsevier Inc.

320 Gb/s Nyquist OTDM received by polarization-insensitive time-domain OFT

DEFF Research Database (Denmark)

Hu, Hao; Kong, Deming; Palushani, Evarist

2014-01-01

We have demonstrated the generation of a 320 Gb/s Nyquist-OTDM signal by rectangular filtering on an RZ-OTDM signal with the filter bandwidth (320 GHz) equal to the baud rate (320 Gbaud) and the reception of such a Nyquist-OTDM signal using polarization-insensitive time-domain optical Fourier tra...

A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves` ophthalmopathy

Energy Technology Data Exchange (ETDEWEB)

Bahn, R.S.; Dutton, C.M.; Heufelder, A.E.; Sarkar, G. [Mayo Clinic/Foundation, Rochester, MN (United States)]|[Ludwig-Maximilians-Universitat, Munich (Germany)

1994-02-01

Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves` ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves` disease and the reason for the association of GO and PTD with hyperthyroidism are unknown. RNA encoding the full-length extracellular domain of the TSH receptor has been demonstrated in orbital and dermal fibroblasts from patients with GO and normal subjects, suggesting a possible antigenic link between fibroblasts and thyrocytes. RNA was isolated from cultured orbital, pretibial, and abdominal fibroblasts obtained from patients with severe GO (n = 22) and normal subjects (n = 5). RNA was reverse transcribed, and the resulting cDNA was amplified by the polymerase chain reaction, using primers spanning overlapping regions of the entire extracellular domain of the TSH receptor. Nucleotide sequence analysis showed an A for C substitution in the first position of codon 52 in 2 of the patients, both of whom had GO, PTD, and acropachy. Genomic DNA isolated from the 2 affected patients, and not from an additional 12 normal subjects, revealed the codon 52 mutation by direct sequencing and AciI restriction enzyme digestions. In conclusion, the authors have demonstrated the presence of a genomic point mutation, leading to a threonine for proline amino acid shift in the predicted peptide, in the extracellular domain of the TSH receptor in two patients with severe GO, PTD, acropachy, and high thyroid-stimulating immunoglobulin levels. RNA encoding this mutant product was demonstrated in the fibroblasts of these patients. They suggest that the TSH receptor may be an important fibroblast autoantigen in GO and PTD, and that this mutant form of the receptor may have unique immunogenic properties. 28 refs., 3 figs., 2 tabs.

Demerit points systems.

NARCIS (Netherlands)

2006-01-01

In 2012, 21 of the 27 EU Member States had some form of demerit points system. In theory, demerit points systems contribute to road safety through three mechanisms: 1) prevention of unsafe behaviour through the risk of receiving penalty points, 2) selection and suspension of the most frequent

A localized interaction surface for voltage-sensing domains on the pore domain of a K+ channel.

Science.gov (United States)

Li-Smerin, Y; Hackos, D H; Swartz, K J

2000-02-01

Voltage-gated K+ channels contain a central pore domain and four surrounding voltage-sensing domains. How and where changes in the structure of the voltage-sensing domains couple to the pore domain so as to gate ion conduction is not understood. The crystal structure of KcsA, a bacterial K+ channel homologous to the pore domain of voltage-gated K+ channels, provides a starting point for addressing this question. Guided by this structure, we used tryptophan-scanning mutagenesis on the transmembrane shell of the pore domain in the Shaker voltage-gated K+ channel to localize potential protein-protein and protein-lipid interfaces. Some mutants cause only minor changes in gating and when mapped onto the KcsA structure cluster away from the interface between pore domain subunits. In contrast, mutants producing large changes in gating tend to cluster near this interface. These results imply that voltage-sensing domains interact with localized regions near the interface between adjacent pore domain subunits.

The Distributed-SDF Domain

DEFF Research Database (Denmark)

Cuadrado, Daniel Lázaro; Ravn, Anders Peter; Koch, Peter

2005-01-01

The purpose of the Distributed-SDF domain for Ptolemy II is to allow distributed simulation of SDF models. It builds on top of the existing SDF domain by extending it. From the user’s point of view, using the Distributed-SDF director is sufficient to run the distributed version. It provides optio...... distributed nature. First of all, known memory bounds of the JVM can be overcome. Second, it yields smaller simulation times, mainly for models with high degree of parallelism and granularity....

A Highly Accurate Regular Domain Collocation Method for Solving Potential Problems in the Irregular Doubly Connected Domains

Directory of Open Access Journals (Sweden)

Zhao-Qing Wang

2014-01-01

Full Text Available Embedding the irregular doubly connected domain into an annular regular region, the unknown functions can be approximated by the barycentric Lagrange interpolation in the regular region. A highly accurate regular domain collocation method is proposed for solving potential problems on the irregular doubly connected domain in polar coordinate system. The formulations of regular domain collocation method are constructed by using barycentric Lagrange interpolation collocation method on the regular domain in polar coordinate system. The boundary conditions are discretized by barycentric Lagrange interpolation within the regular domain. An additional method is used to impose the boundary conditions. The least square method can be used to solve the overconstrained equations. The function values of points in the irregular doubly connected domain can be calculated by barycentric Lagrange interpolation within the regular domain. Some numerical examples demonstrate the effectiveness and accuracy of the presented method.

Principles of Eliminating Access Control Lists within a Domain

Directory of Open Access Journals (Sweden)

Vic Grout

2012-04-01

Full Text Available The infrastructure of large networks is broken down into areas that have a common security policy called a domain. Security within a domain is commonly implemented at all nodes. However this can have a negative effect on performance since it introduces a delay associated with packet filtering. When Access Control Lists (ACLs are used within a router for this purpose then a significant overhead is introduced associated with this process. It is likely that identical checks are made at multiple points within a domain prior to a packet reaching its destination. Therefore by eliminating ACLs within a domain by modifying the ingress/egress points with equivalent functionality an improvement in the overall performance can be obtained. This paper considers the effect of the delays when using router operating systems offering different levels of functionality. It considers factors which contribute to the delay particularly due to ACLs and by using theoretical principles modified by practical calculation a model is created. Additionally this paper provides an example of an optimized solution which reduces the delay through network routers by distributing the security rules to the ingress/egress points of the domain without affecting the security policy.

Exploiting Redundancy in an OFDM SDR Receiver

Directory of Open Access Journals (Sweden)

Tomas Palenik

2009-01-01

Full Text Available Common OFDM system contains redundancy necessary to mitigate interblock interference and allows computationally effective single-tap frequency domain equalization in receiver. Assuming the system implements an outer error correcting code and channel state information is available in the receiver, we show that it is possible to understand the cyclic prefix insertion as a weak inner ECC encoding and exploit the introduced redundancy to slightly improve error performance of such a system. In this paper, an easy way to implement modification to an existing SDR OFDM receiver is presented. This modification enables the utilization of prefix redundancy, while preserving full compatibility with existing OFDM-based communication standards.

Axion-dilaton domain walls and fake supergravity

International Nuclear Information System (INIS)

Sonner, Julian; Townsend, Paul K

2007-01-01

Dynamical systems methods are used to investigate domain-wall solutions of a two-parameter family of models in which gravity is coupled to an axion and to a dilaton with an exponential potential of either sign. A complete global analysis is presented for (i) constant axion and (ii) flat walls, including a study of bifurcations and a new exact domain-wall solution with non-constant axion. We reconsider 'fake-supergravity' issues in light of these results. We show, by example, how domain walls determine multi-valued superpotentials that branch at stationary points that are not stationary points of the potential, and we apply this result to potentials with anti-de Sitter vacua. We also show by example that 'adapted' truncation to a single-scalar model may be inconsistent, and we propose a 'generalized' fake-supergravity formalism that applies in some such cases

Ultrasound sounding in air by fast-moving receiver

Science.gov (United States)

Sukhanov, D.; Erzakova, N.

2018-05-01

A method of ultrasound imaging in the air for a fast receiver. The case, when the speed of movement of the receiver can not be neglected with respect to the speed of sound. In this case, the Doppler effect is significant, making it difficult for matched filtering of the backscattered signal. The proposed method does not use a continuous repetitive noise-sounding signal. generalized approach applies spatial matched filtering in the time domain to recover the ultrasonic tomographic images.

Reduced Complexity Detection in MIMO Systems with SC-FDE Modulations and Iterative DFE Receivers

Directory of Open Access Journals (Sweden)

Filipe Casal Ribeiro

2018-04-01

Full Text Available This paper considers a Multiple-Input Multiple-Output (MIMO system with P transmitting and R receiving antennas and different overall noise characteristics on the different receiver antennas (e.g., due to nonlinear effects at the receiver side. Each communication link employs a Single-Carrier with Frequency-Domain Equalization (SC-FDE modulation scheme, and the receiver is based on robust iterative frequency-domain multi-user detectors based on the Iterative Block Decision Feedback Equalization (IB-DFE concept. We present low complexity efficient receivers that can employ low resolution Analog-to-Digital Converters (ADCs and require the inversion of matrices with reduced dimension when the number of receive antennas is larger than the number of independent data streams. The advantages of the proposed techniques are particularly high for highly unbalanced MIMO systems, such as in the uplink of Base Station (BS cooperation systems that aim for Single-Frequency Network (SFN operation or massive MIMO systems with much more antennas at the receiver side.

Imaging Crustal Structure of East Central United States using receiver function and implications for the accretion of juvenile crust

Science.gov (United States)

Deng, S.; Levander, A.

2017-12-01

Almost half of the North American continental plate is formed by the juvenile terrane accretion between 1.8-1.0 Ga, therefore, the suturing process of juvenile crust in East Central United States, not receiving as much attention probably due to low station coverage before the deployment of US transportable array, is of great importance to better understand the evolution of North American Plate. The Yavapai province is formed by the accretion of juvenile crust during 1.8-1.7 Ga. The northeastern part of Yavapai province is accreted to the Superior province along the Spirit Lake Tectonic Zone (SLTZ). During the period of 1.7-1.6 Ga, the Mazatzal Province, bounded the south of Yavapai Province, was added to Laurentia. The previous research mainly focuses on the southwestern Yavapai-Mazatzal boundary (Karlstrom et.al 2002, Magnani et.al 2004) but less in the northeastern area that we are interested in. The Granite-Rhyolite province is the product of the suturing event of juvenile arc crust reoccurring along the southeast margin of Laurentia between 1.55-1.35 Ga, which has been proved by the Nd model age (Whitmeyer et.al 2007). Here we will select the Mw>=5.5 teleseismic events with epicenter distance between 35 and 90 recorded by 300 available seismic stations in our study region. The receiver functions will be calculated by the water-level deconvolution in frequency domain (Langston 1979) and iterative deconvolution in time domain (Ligorria et.al 1999). The common conversion point (CCP) stacking method will then be applied to the receiver functions to create the 3-D image volume by imaging the conversion points in space from the time domain signals (Levander and Miller 2012). The preliminary results show that the accretion process of the tectonic provinces may have different models. The profiles of CCP image volume will inform us the seismic evidence to model the suturing process of juvenile Yavapai, Mozatzal and Granite-Rhyolite crust, hence providing great

1.28 Tbaud Nyquist Signal Transmission using Time-Domain Optical Fourier Transformation based Receiver

DEFF Research Database (Denmark)

Hu, Hao; Kong, Deming; Palushani, Evarist

2013-01-01

We demonstrate transmission of a 1.28-Tbaud Nyquist-OTDM signal over a record distance of 100 km with detection by time-domain optical Fourier transformation followed by FEC decoding, resulting in error-free performance for all tributaries....

Domain Discretization and Circle Packings

DEFF Research Database (Denmark)

Dias, Kealey

A circle packing is a configuration of circles which are tangent with one another in a prescribed pattern determined by a combinatorial triangulation, where the configuration fills a planar domain or a two-dimensional surface. The vertices in the triangulation correspond to centers of circles...... to domain discretization problems such as triangulation and unstructured mesh generation techniques. We wish to ask ourselves the question: given a cloud of points in the plane (we restrict ourselves to planar domains), is it possible to construct a circle packing preserving the positions of the vertices...... and constrained meshes having predefined vertices as constraints. A standard method of two-dimensional mesh generation involves conformal mapping of the surface or domain to standardized shapes, such as a disk. Since circle packing is a new technique for constructing discrete conformal mappings, it is possible...

The Pervasive Power of PowerPoint

DEFF Research Database (Denmark)

Schoeneborn, Dennis

2013-01-01

This paper examines the pervasive role of Microsoft’s presentation software PowerPoint as a genre of professional and organizational communication. Frequently, PowerPoint is not only used for the primary function it was initially designed for, i.e., facilitating live presentations, but also...... for alternative purposes such as project documentation. Its application in a neighboring domain, however, poses a functional dilemma: does the PowerPoint genre preserve the features of its primary function, i.e., presentation, or rather adapt to the new function, i.e., documentation? By drawing on a communication......-centered perspective, this paper examines PowerPoint’s role in the domain of project documentation as a clash between the constitutive affordances of professional and of organizational communication. To investigate this issue empirically, I conducted a case study at a multinational business consulting firm. The study...

An Array of Optical Receivers for Deep-Space Communications

Science.gov (United States)

Vilnrotter, Chi-Wung; Srinivasan, Meera; Andrews, Kenneth

2007-01-01

An array of small optical receivers is proposed as an alternative to a single large optical receiver for high-data-rate communications in NASA s Deep Space Network (DSN). Because the telescope for a single receiver capable of satisfying DSN requirements must be greater than 10 m in diameter, the design, building, and testing of the telescope would be very difficult and expensive. The proposed array would utilize commercially available telescopes of 1-m or smaller diameter and, therefore, could be developed and verified with considerably less difficulty and expense. The essential difference between a single-aperture optical-communications receiver and an optical-array receiver is that a single-aperture receiver focuses all of the light energy it collects onto the surface of an optical detector, whereas an array receiver focuses portions of the total collected energy onto separate detectors, optically detects each fractional energy component, then combines the electrical signal from the array of detector outputs to form the observable, or "decision statistic," used to decode the transmitted data. A conceptual block diagram identifying the key components of the optical-array receiver suitable for deep-space telemetry reception is shown in the figure. The most conspicuous feature of the receiver is the large number of small- to medium-size telescopes, with individual apertures and number of telescopes selected to make up the desired total collecting area. This array of telescopes is envisioned to be fully computer- controlled via the user interface and prediction-driven to achieve rough pointing and tracking of the desired spacecraft. Fine-pointing and tracking functions then take over to keep each telescope pointed toward the source, despite imperfect pointing predictions, telescope-drive errors, and vibration caused by wind.

A Novel Transfer Learning Method Based on Common Space Mapping and Weighted Domain Matching

KAUST Repository

Liang, Ru-Ze; Xie, Wei; Li, Weizhi; Wang, Hongqi; Wang, Jim Jing-Yan; Taylor, Lisa

2017-01-01

In this paper, we propose a novel learning framework for the problem of domain transfer learning. We map the data of two domains to one single common space, and learn a classifier in this common space. Then we adapt the common classifier to the two domains by adding two adaptive functions to it respectively. In the common space, the target domain data points are weighted and matched to the target domain in term of distributions. The weighting terms of source domain data points and the target domain classification responses are also regularized by the local reconstruction coefficients. The novel transfer learning framework is evaluated over some benchmark cross-domain data sets, and it outperforms the existing state-of-the-art transfer learning methods.

A Novel Transfer Learning Method Based on Common Space Mapping and Weighted Domain Matching

KAUST Repository

Liang, Ru-Ze

2017-01-17

In this paper, we propose a novel learning framework for the problem of domain transfer learning. We map the data of two domains to one single common space, and learn a classifier in this common space. Then we adapt the common classifier to the two domains by adding two adaptive functions to it respectively. In the common space, the target domain data points are weighted and matched to the target domain in term of distributions. The weighting terms of source domain data points and the target domain classification responses are also regularized by the local reconstruction coefficients. The novel transfer learning framework is evaluated over some benchmark cross-domain data sets, and it outperforms the existing state-of-the-art transfer learning methods.

Domain Adaptation for Machine Translation with Instance Selection

Directory of Open Access Journals (Sweden)

Biçici Ergun

2015-04-01

Full Text Available Domain adaptation for machine translation (MT can be achieved by selecting training instances close to the test set from a larger set of instances. We consider 7 different domain adaptation strategies and answer 7 research questions, which give us a recipe for domain adaptation in MT. We perform English to German statistical MT (SMT experiments in a setting where test and training sentences can come from different corpora and one of our goals is to learn the parameters of the sampling process. Domain adaptation with training instance selection can obtain 22% increase in target 2-gram recall and can gain up to 3:55 BLEU points compared with random selection. Domain adaptation with feature decay algorithm (FDA not only achieves the highest target 2-gram recall and BLEU performance but also perfectly learns the test sample distribution parameter with correlation 0:99. Moses SMT systems built with FDA selected 10K training sentences is able to obtain F1 results as good as the baselines that use up to 2M sentences. Moses SMT systems built with FDA selected 50K training sentences is able to obtain F1 point better results than the baselines.

Adaptive spatial filtering of daytime sky noise in a satellite quantum key distribution downlink receiver

Science.gov (United States)

Gruneisen, Mark T.; Sickmiller, Brett A.; Flanagan, Michael B.; Black, James P.; Stoltenberg, Kurt E.; Duchane, Alexander W.

2016-02-01

Spatial filtering is an important technique for reducing sky background noise in a satellite quantum key distribution downlink receiver. Atmospheric turbulence limits the extent to which spatial filtering can reduce sky noise without introducing signal losses. Using atmospheric propagation and compensation simulations, the potential benefit of adaptive optics (AO) to secure key generation (SKG) is quantified. Simulations are performed assuming optical propagation from a low-Earth-orbit satellite to a terrestrial receiver that includes AO. Higher-order AO correction is modeled assuming a Shack-Hartmann wavefront sensor and a continuous-face-sheet deformable mirror. The effects of atmospheric turbulence, tracking, and higher-order AO on the photon capture efficiency are simulated using statistical representations of turbulence and a time-domain wave-optics hardware emulator. SKG rates are calculated for a decoy-state protocol as a function of the receiver field of view for various strengths of turbulence, sky radiances, and pointing angles. The results show that at fields of view smaller than those discussed by others, AO technologies can enhance SKG rates in daylight and enable SKG where it would otherwise be prohibited as a consequence of background optical noise and signal loss due to propagation and turbulence effects.

The Consequences of Chronic Stereotype Threat: Domain Disidentification and Abandonment

OpenAIRE

Woodcock, Anna; Hernandez, Paul R.; Estrada, Mica; Schultz, P. Wesley

2012-01-01

Stereotype threat impairs performance across many domains. Despite a wealth of research, the long-term consequences of chronic stereotype threat have received little empirical attention. Beyond the immediate impact on performance, the experience of chronic stereotype threat is hypothesized to lead to domain disidentification and eventual domain abandonment. Stereotype threat is 1 explanation why African Americans and Hispanic/Latino(a)s “leak” from each juncture of the academic scientific pip...

Some asymptotic properties of functions holomorphic in tubular domains

International Nuclear Information System (INIS)

Zavialov, B.I.

1988-10-01

For the function holomorphic in curved tubular domain the connection between asymptotic behaviour of real part of its boundary value at a given point of base manifold and asymptotic behaviour of the whole function from the inside of this domain is studied. (author). 3 refs

Fourier transform coupled tryptophan scanning mutagenesis identifies a bending point on the lipid-exposed δM3 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor

Science.gov (United States)

Caballero-Rivera, Daniel; Cruz-Nieves, Omar A; Oyola-Cintrón, Jessica; Torres-Núñez, David A; Otero-Cruz, José D

2011-01-01

The nicotinic acetylcholine receptor (nAChR) is a member of a family of ligand-gated ion channels that mediate diverse physiological functions, including fast synaptic transmission along the peripheral and central nervous systems. Several studies have made significant advances toward determining the structure and dynamics of the lipid-exposed domains of the nAChR. However, a high-resolution atomic structure of the nAChR still remains elusive. In this study, we extended the Fourier transform coupled tryptophan scanning mutagenesis (FT-TrpScanM) approach to gain insight into the secondary structure of the δM3 transmembrane domain of the Torpedo californica nAChR, to monitor conformational changes experienced by this domain during channel gating, and to identify which lipid-exposed positions are linked to the regulation of ion channel kinetics. The perturbations produced by periodic tryptophan substitutions along the δM3 transmembrane domain were characterized by two-electrode voltage clamp and 125I-labeled α-bungarotoxin binding assays. The periodicity profiles and Fourier transform spectra of this domain revealed similar helical structures for the closed- and open-channel states. However, changes in the oscillation patterns observed between positions Val-299 and Val-304 during transition between the closed- and open-channel states can be explained by the structural effects caused by the presence of a bending point introduced by a Thr-Gly motif at positions 300–301. The changes in periodicity and localization of residues between the closed-and open-channel states could indicate a structural transition between helix types in this segment of the domain. Overall, the data further demonstrate a functional link between the lipid-exposed transmembrane domain and the nAChR gating machinery. PMID:21785268

Growth of solid domains in model membranes: quantitative image analysis reveals a strong correlation between domain shape and spatial position

DEFF Research Database (Denmark)

Bernchou, Uffe; Ipsen, John Hjort; Simonsen, Adam Cohen

2009-01-01

. To analyze this effect, the nucleation points were used as generators in a Voronoi construction. Associated with each generator is a Voronoi polygon that contains all points closer to this generator than to any other. Through a detailed quantitative analysis of the Voronoi cells and the domains, we have...

[The treatment received by public health services users in Mexico].

Science.gov (United States)

Puentes Rosas, Esteban; Gómez Dantés, Octavio; Garrido Latorre, Francisco

2006-06-01

To document the fact that differences in the treatment received by health services users in Mexico are mainly dependent on the type of provider, regardless of the users' socioeconomic status. The data were obtained by means of a survey of 18 018 users who visited 73 health services in 13 states within Mexico. They were asked to grade the way the institution had performed in seven of the eight domains that define appropriate user treatment (autonomy, confidentiality, communication, respectful manner, condition of basic facilities, access to social assistance networks, and free user choice). The questionnaire included some vignettes to help determine user expectations. A composite ordinal probit model was applied; the perception of quality in connection with each of the appropriate treatment domains was the independent variable, whereas gender, educational level, age, type of provider, and user expectations were used as control variables. The type of provider was the main factor that determined users' perceptions regarding the treatment they received when visiting health services in Mexico. Institutions belonging to the social security system performed the worst, while the services provided under the program targeting the rural population (IMSS Oportunidades) received the highest scores. Overall, the domain that was most highly ranked was respectful manner, whereas the lowest score was given to the ability to choose the provider. Men felt they had been able to communicate better than women, while respectful manner, communication, and social support showed a significant negative association with educational level (P < 0.05). Differences were noted in the way different public health service providers in Mexico treat their users, regardless of the latter's socioeconomic status. Social security system providers showed the greatest deficiencies in this respect. Respectful manner was the domain that received the highest scores in the case of all providers. Organizational

Efficient triangulation of Poisson-disk sampled point sets

KAUST Repository

Guo, Jianwei

2014-05-06

In this paper, we present a simple yet efficient algorithm for triangulating a 2D input domain containing a Poisson-disk sampled point set. The proposed algorithm combines a regular grid and a discrete clustering approach to speedup the triangulation. Moreover, our triangulation algorithm is flexible and performs well on more general point sets such as adaptive, non-maximal Poisson-disk sets. The experimental results demonstrate that our algorithm is robust for a wide range of input domains and achieves significant performance improvement compared to the current state-of-the-art approaches. © 2014 Springer-Verlag Berlin Heidelberg.

Compressed sensing techniques for receiver based post-compensation of transmitter's nonlinear distortions in OFDM systems

KAUST Repository

Owodunni, Damilola S.; Ali, Anum Z.; Quadeer, Ahmed Abdul; Al-Safadi, Ebrahim B.; Hammi, Oualid; Al-Naffouri, Tareq Y.

2014-01-01

-domain, and three compressed sensing based algorithms are presented to estimate and compensate for these distortions at the receiver using a few and, at times, even no frequency-domain free carriers (i.e. pilot carriers). The first technique is a conventional

Differences between time domain and Fourier domain optical coherence tomography in imaging tissues.

Science.gov (United States)

Gao, W; Wu, X

2017-11-01

It has been numerously demonstrated that both time domain and Fourier domain optical coherence tomography (OCT) can generate high-resolution depth-resolved images of living tissues and cells. In this work, we compare the common points and differences between two methods when the continuous and random properties of live tissue are taken into account. It is found that when relationships that exist between the scattered light and tissue structures are taken into account, spectral interference measurements in Fourier domain OCT (FDOCT) is more advantageous than interference fringe envelope measurements in time domain OCT (TDOCT) in the cases where continuous property of tissue is taken into account. It is also demonstrated that when random property of tissue is taken into account FDOCT measures the Fourier transform of the spatial correlation function of the refractive index and speckle phenomena will limit the effective limiting imaging resolution in both TDOCT and FDOCT. Finally, the effective limiting resolution of both TDOCT and FDOCT are given which can be used to estimate the effective limiting resolution in various practical applications. © 2017 The Authors Journal of Microscopy © 2017 Royal Microscopical Society.

Controlling Pulsed EM Scattering of a One-Port Receiving Antenna

Science.gov (United States)

Štumpf, Martin

2017-12-01

A time domain compensation theorem concerning electromagnetic (EM) scattering of a one-port antenna system is derived with the aid of the reciprocity theorem of the time convolution type. The theorem describes the impact of a change in the antenna load on receiving antenna scattering properties. The compensation theorem is next applied to express the change of the copolarized backscattered far-field amplitude in terms of (local) Kirchhoff circuit quantities excited in the corresponding receiving scenarios. Applications of the results can be found in controlling the pulsed echo of a receiving antenna as well as in related theoretical aspects of receiving antenna scattering theory. Illustrative numerical results are given for both linear and nonlinear antenna loads.

On the Required Number of Antennas in a Point-to-Point Large-but-Finite MIMO System

KAUST Repository

Makki, Behrooz; Svensson, Tommy; Eriksson, Thomas; Alouini, Mohamed-Slim

2015-01-01

In this paper, we investigate the performance of the point-to-point multiple-input-multiple-output (MIMO) systems in the presence of a large but finite numbers of antennas at the transmitters and/or receivers. Considering the cases with and without hybrid automatic repeat request (HARQ) feedback, we determine the minimum numbers of the transmit/receive antennas which are required to satisfy different outage probability constraints. We study the effect of the spatial correlation between the antennas on the system performance. Also, the required number of antennas are obtained for different fading conditions. Our results show that different outage requirements can be satisfied with relatively few transmit/receive antennas. © 2015 IEEE.

On the Required Number of Antennas in a Point-to-Point Large-but-Finite MIMO System

KAUST Repository

Makki, Behrooz

2015-11-12

In this paper, we investigate the performance of the point-to-point multiple-input-multiple-output (MIMO) systems in the presence of a large but finite numbers of antennas at the transmitters and/or receivers. Considering the cases with and without hybrid automatic repeat request (HARQ) feedback, we determine the minimum numbers of the transmit/receive antennas which are required to satisfy different outage probability constraints. We study the effect of the spatial correlation between the antennas on the system performance. Also, the required number of antennas are obtained for different fading conditions. Our results show that different outage requirements can be satisfied with relatively few transmit/receive antennas. © 2015 IEEE.

Full traveltime inversion in source domain

KAUST Repository

Liu, Lu

2017-06-01

This paper presents a new method of source-domain full traveltime inversion (FTI). The objective of this study is automatically building near-surface velocity using the early arrivals of seismic data. This method can generate the inverted velocity that can kinetically best match the reconstructed plane-wave source of early arrivals with true source in source domain. It does not require picking first arrivals for tomography, which is one of the most challenging aspects of ray-based tomographic inversion. Besides, this method does not need estimate the source wavelet, which is a necessity for receiver-domain wave-equation velocity inversion. Furthermore, we applied our method on one synthetic dataset; the results show our method could generate a reasonable background velocity even when shingling first arrivals exist and could provide a good initial velocity for the conventional full waveform inversion (FWI).

Kinematics of reflections in subsurface offset and angle-domain image gathers

Science.gov (United States)

Dafni, Raanan; Symes, William W.

2018-05-01

Seismic migration in the angle-domain generates multiple images of the earth's interior in which reflection takes place at different scattering-angles. Mechanically, the angle-dependent reflection is restricted to happen instantaneously and at a fixed point in space: Incident wave hits a discontinuity in the subsurface media and instantly generates a scattered wave at the same common point of interaction. Alternatively, the angle-domain image may be associated with space-shift (regarded as subsurface offset) extended migration that artificially splits the reflection geometry. Meaning that, incident and scattered waves interact at some offset distance. The geometric differences between the two approaches amount to a contradictory angle-domain behaviour, and unlike kinematic description. We present a phase space depiction of migration methods extended by the peculiar subsurface offset split and stress its profound dissimilarity. In spite of being in radical contradiction with the general physics, the subsurface offset reveals a link to some valuable angle-domain quantities, via post-migration transformations. The angle quantities are indicated by the direction normal to the subsurface offset extended image. They specifically define the local dip and scattering angles if the velocity at the split reflection coordinates is the same for incident and scattered wave pairs. Otherwise, the reflector normal is not a bisector of the opening angle, but of the corresponding slowness vectors. This evidence, together with the distinguished geometry configuration, fundamentally differentiates the angle-domain decomposition based on the subsurface offset split from the conventional decomposition at a common reflection point. An asymptotic simulation of angle-domain moveout curves in layered media exposes the notion of split versus common reflection point geometry. Traveltime inversion methods that involve the subsurface offset extended migration must accommodate the split geometry

Structural stability of human protein tyrosine phosphatase ρ catalytic domain: effect of point mutations.

Directory of Open Access Journals (Sweden)

Alessandra Pasquo

Full Text Available Protein tyrosine phosphatase ρ (PTPρ belongs to the classical receptor type IIB family of protein tyrosine phosphatase, the most frequently mutated tyrosine phosphatase in human cancer. There are evidences to suggest that PTPρ may act as a tumor suppressor gene and dysregulation of Tyr phosphorylation can be observed in diverse diseases, such as diabetes, immune deficiencies and cancer. PTPρ variants in the catalytic domain have been identified in cancer tissues. These natural variants are nonsynonymous single nucleotide polymorphisms, variations of a single nucleotide occurring in the coding region and leading to amino acid substitutions. In this study we investigated the effect of amino acid substitution on the structural stability and on the activity of the membrane-proximal catalytic domain of PTPρ. We expressed and purified as soluble recombinant proteins some of the mutants of the membrane-proximal catalytic domain of PTPρ identified in colorectal cancer and in the single nucleotide polymorphisms database. The mutants show a decreased thermal and thermodynamic stability and decreased activation energy relative to phosphatase activity, when compared to wild- type. All the variants show three-state equilibrium unfolding transitions similar to that of the wild- type, with the accumulation of a folding intermediate populated at ~4.0 M urea.

The ethnographic method and its relationship with the domain analysis

Directory of Open Access Journals (Sweden)

Manuel Alejandro Romero Quesada

2016-03-01

Full Text Available This paper analyzes the theoretical and conceptual relationship of the ethnographic method with domain analysis. A documentary analysis was performed, exploring the categories of domain analysis and ethnographic method.It was obtained as a result: the analysis of the points of contact between domain analysis and the ethnographic method from an epistemological, methodological and procedural terms. It is concluded that the ethnographic method is an important research tool to scan the turbulent socio-cultural scenarios that occur within discursive communities that constitute the domains of knowledge.

Analysis of the Diffuse Domain Method for Second Order Elliptic Boundary Value Problems

NARCIS (Netherlands)

Burger, Martin; Elvetun, Ole; Schlottbom, Matthias

2017-01-01

The diffuse domain method for partial differential equations on complicated geometries recently received strong attention in particular from practitioners, but many fundamental issues in the analysis are still widely open. In this paper, we study the diffuse domain method for approximating second

An Interoperability Consideration in Selecting Domain Parameters for Elliptic Curve Cryptography

Science.gov (United States)

Ivancic, Will (Technical Monitor); Eddy, Wesley M.

2005-01-01

Elliptic curve cryptography (ECC) will be an important technology for electronic privacy and authentication in the near future. There are many published specifications for elliptic curve cryptosystems, most of which contain detailed descriptions of the process for the selection of domain parameters. Selecting strong domain parameters ensures that the cryptosystem is robust to attacks. Due to a limitation in several published algorithms for doubling points on elliptic curves, some ECC implementations may produce incorrect, inconsistent, and incompatible results if domain parameters are not carefully chosen under a criterion that we describe. Few documents specify the addition or doubling of points in such a manner as to avoid this problematic situation. The safety criterion we present is not listed in any ECC specification we are aware of, although several other guidelines for domain selection are discussed in the literature. We provide a simple example of how a set of domain parameters not meeting this criterion can produce catastrophic results, and outline a simple means of testing curve parameters for interoperable safety over doubling.

A protein-targeting strategy used to develop a selective inhibitor of the E17K point mutation in the PH domain of Akt1

Science.gov (United States)

Deyle, Kaycie M.; Farrow, Blake; Qiao Hee, Ying; Work, Jeremy; Wong, Michelle; Lai, Bert; Umeda, Aiko; Millward, Steven W.; Nag, Arundhati; Das, Samir; Heath, James R.

2015-05-01

Ligands that can bind selectively to proteins with single amino-acid point mutations offer the potential to detect or treat an abnormal protein in the presence of the wild type (WT). However, it is difficult to develop a selective ligand if the point mutation is not associated with an addressable location, such as a binding pocket. Here we report an all-chemical synthetic epitope-targeting strategy that we used to discover a 5-mer peptide with selectivity for the E17K-transforming point mutation in the pleckstrin homology domain of the Akt1 oncoprotein. A fragment of Akt1 that contained the E17K mutation and an I19[propargylglycine] substitution was synthesized to form an addressable synthetic epitope. Azide-presenting peptides that clicked covalently onto this alkyne-presenting epitope were selected from a library using in situ screening. One peptide exhibits a 10:1 in vitro selectivity for the oncoprotein relative to the WT, with a similar selectivity in cells. This 5-mer peptide was expanded into a larger ligand that selectively blocks the E17K Akt1 interaction with its PIP3 (phosphatidylinositol (3,4,5)-trisphosphate) substrate.

Domain-wall dynamics in glass-coated magnetic microwires

International Nuclear Information System (INIS)

Varga, R.; Zhukov, A.; Usov, N.; Blanco, J.M.; Gonzalez, J.; Zhukova, V.; Vojtanik, P.

2007-01-01

Glass-coated magnetic microwires with positive magnetostriction show peculiar domain structure that consists mostly of one large domain with magnetization-oriented axially. It was shown that small closure domains appear at the end of the microwire in order to decrease the stray fields. As a result of such domain structure, the magnetization reversal in axial direction runs through the depinning of one of such closure domains and subsequent propagation of the corresponding domain wall. Quite unusual domain-wall (DW) dynamics of the DW propagation predicted previously from the theory has been found in such amorphous microwires. In this paper, we are dealing with the DW dynamics of glass-coated microwires with small positive magnetostriction. The DW damping coming from the structural relaxation dominates at low temperatures as a result of the decrease of the mobility of the structural atomic-level defects. Negative critical propagation field points to the possible DW propagation without applied magnetic field. Probable explanation could be in terms of the effective mass of the DW

DC-SIGN neck domain is a pH-sensor controlling oligomerization: SAXS and hydrodynamic studies of extracellular domain.

Science.gov (United States)

Tabarani, Georges; Thépaut, Michel; Stroebel, David; Ebel, Christine; Vivès, Corinne; Vachette, Patrice; Durand, Dominique; Fieschi, Franck

2009-08-07

DC-SIGN is a C-type lectin receptor of dendritic cells and is involved in the early stages of numerous infectious diseases. DC-SIGN is organized into a tetramer enabling multivalent interaction with pathogens. Once formed, the DC-SIGN-pathogen complex can be internalized into compartments of increasing acidity. We have studied the pH dependence of the oligomerization state and conformation of the entire extracellular domain and neck region. We present evidence for equilibrium between the monomeric and tetrameric states of the extracellular domain, which exhibits a marked dependence with respect to both pH and ionic strength. Using solution x-ray scattering we have obtained a molecular envelope of the extracellular domain in which a model has been built. Our results highlight the central role of the neck domain in the pH-sensitive control of the oligomerization state, in the extended conformation of the protein, and in carbohydrate recognition domain organization and presentation. This work opens new insight into the molecular mechanism of ligand release and points to new avenues to block the first step of this important infection pathway.

Finding Commonalities: Social Information Processing and Domain Theory in the Study of Aggression

Science.gov (United States)

Nucci, Larry

2004-01-01

The Arsenio and Lemerise (this issue) proposal integrating social information processing (SIP) and domain theory to study children's aggression is evaluated from a domain theory perspective. Basic tenets of domain theory rendering it compatible with SIP are discussed as well as points of divergence. Focus is directed to the proposition that…

Localization of Point Sources for Poisson Equation using State Observers

KAUST Repository

Majeed, Muhammad Usman

2016-08-09

A method based On iterative observer design is presented to solve point source localization problem for Poisson equation with riven boundary data. The procedure involves solution of multiple boundary estimation sub problems using the available Dirichlet and Neumann data from different parts of the boundary. A weighted sum of these solution profiles of sub-problems localizes point sources inside the domain. Method to compute these weights is also provided. Numerical results are presented using finite differences in a rectangular domain. (C) 2016, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

Localization of Point Sources for Poisson Equation using State Observers

KAUST Repository

Majeed, Muhammad Usman; Laleg-Kirati, Taous-Meriem

2016-01-01

A method based On iterative observer design is presented to solve point source localization problem for Poisson equation with riven boundary data. The procedure involves solution of multiple boundary estimation sub problems using the available Dirichlet and Neumann data from different parts of the boundary. A weighted sum of these solution profiles of sub-problems localizes point sources inside the domain. Method to compute these weights is also provided. Numerical results are presented using finite differences in a rectangular domain. (C) 2016, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

Broadband direct RF digitization receivers

CERN Document Server

Jamin, Olivier

2014-01-01

This book discusses the trade-offs involved in designing direct RF digitization receivers for the radio frequency and digital signal processing domains.  A system-level framework is developed, quantifying the relevant impairments of the signal processing chain, through a comprehensive system-level analysis.  Special focus is given to noise analysis (thermal noise, quantization noise, saturation noise, signal-dependent noise), broadband non-linear distortion analysis, including the impact of the sampling strategy (low-pass, band-pass), analysis of time-interleaved ADC channel mismatches, sampling clock purity and digital channel selection. The system-level framework described is applied to the design of a cable multi-channel RF direct digitization receiver. An optimum RF signal conditioning, and some algorithms (automatic gain control loop, RF front-end amplitude equalization control loop) are used to relax the requirements of a 2.7GHz 11-bit ADC. A two-chip implementation is presented, using BiCMOS and 65nm...

Clock domain crossing modules for OCP-style read/write interfaces

DEFF Research Database (Denmark)

Herlev, Mathias; Sparsø, Jens

The open core protocol (OCP) is an openly licensed, configurable, and scalable interface protocol for on-chip subsystem communications. The protocol defines read and write transactions from a master towards a slave across a point-to-point connection and the protocol assumes a single common clock....... This paper presents the design of two OCP clock domain crossing interface modules, that can be used to construct systems with multiple clock domains. One module (called OCPio) supports a single word read-write interface and the other module (called OCPburst) supports a four word burst read-write interface......-style read-write transaction interfaces. An OCP interface typically has control signals related to both the master issuing a read or write request and the slave producing a response. If all these control signals are passed across the clock domain boundary and synchronized it may add significant latency...

Performance Evaluation of Irbene RT-16 Radio Telescope Receiving System

Directory of Open Access Journals (Sweden)

Bleiders M.

2017-12-01

Full Text Available In the present paper, recent measurement results of refurbished Irbene RT-16 radio telescope receiving system performance are presented. The aim of the research is to evaluate characteristics of RT-16, which will allow carrying out necessary amplitude calibration in both single dish and VLBI observations, to improve the performance of existing system as well as to monitor, control and compare performance if possible changes in the receiving system will occur in future. The evaluated receiving system is 16 m Cassegrain antenna equipped with a cryogenic receiver with frequency range from 4.5 to 8.8 GHz, which is divided into four sub-bands. Multiple calibration sessions have been carried out by observing stable astronomical sources with known flux density by using in-house made total power registration backend. First, pointing offset calibration has been carried out and pointing model coefficients calculated and applied. Then, amplitude calibration, namely antenna sensitivity, calibration diode equivalent flux density and gain curve measurements have been carried out by observing calibration sources at different antenna elevations at each of the receiver sub-bands. Beam patterns have also been evaluated at different frequency bands. As a whole, acquired data will serve as a reference point for comparison in future performance evaluation of RT-16.

Monolithic optoelectronic integrated broadband optical receiver with graphene photodetectors

Directory of Open Access Journals (Sweden)

Cheng Chuantong

2017-07-01

Full Text Available Optical receivers with potentially high operation bandwidth and low cost have received considerable interest due to rapidly growing data traffic and potential Tb/s optical interconnect requirements. Experimental realization of 65 GHz optical signal detection and 262 GHz intrinsic operation speed reveals the significance role of graphene photodetectors (PDs in optical interconnect domains. In this work, a novel complementary metal oxide semiconductor post-backend process has been developed for integrating graphene PDs onto silicon integrated circuit chips. A prototype monolithic optoelectronic integrated optical receiver has been successfully demonstrated for the first time. Moreover, this is a firstly reported broadband optical receiver benefiting from natural broadband light absorption features of graphene material. This work is a perfect exhibition of the concept of monolithic optoelectronic integration and will pave way to monolithically integrated graphene optoelectronic devices with silicon ICs for three-dimensional optoelectronic integrated circuit chips.

Monolithic optoelectronic integrated broadband optical receiver with graphene photodetectors

Science.gov (United States)

Cheng, Chuantong; Huang, Beiju; Mao, Xurui; Zhang, Zanyun; Zhang, Zan; Geng, Zhaoxin; Xue, Ping; Chen, Hongda

2017-07-01

Optical receivers with potentially high operation bandwidth and low cost have received considerable interest due to rapidly growing data traffic and potential Tb/s optical interconnect requirements. Experimental realization of 65 GHz optical signal detection and 262 GHz intrinsic operation speed reveals the significance role of graphene photodetectors (PDs) in optical interconnect domains. In this work, a novel complementary metal oxide semiconductor post-backend process has been developed for integrating graphene PDs onto silicon integrated circuit chips. A prototype monolithic optoelectronic integrated optical receiver has been successfully demonstrated for the first time. Moreover, this is a firstly reported broadband optical receiver benefiting from natural broadband light absorption features of graphene material. This work is a perfect exhibition of the concept of monolithic optoelectronic integration and will pave way to monolithically integrated graphene optoelectronic devices with silicon ICs for three-dimensional optoelectronic integrated circuit chips.

Fixed points of quantum gravity in extra dimensions

International Nuclear Information System (INIS)

Fischer, Peter; Litim, Daniel F.

2006-01-01

We study quantum gravity in more than four dimensions with renormalisation group methods. We find a non-trivial ultraviolet fixed point in the Einstein-Hilbert action. The fixed point connects with the perturbative infrared domain through finite renormalisation group trajectories. We show that our results for fixed points and related scaling exponents are stable. If this picture persists at higher order, quantum gravity in the metric field is asymptotically safe. We discuss signatures of the gravitational fixed point in models with low scale quantum gravity and compact extra dimensions

Domain walls in single-chain magnets

Science.gov (United States)

Pianet, Vivien; Urdampilleta, Matias; Colin, Thierry; Clérac, Rodolphe; Coulon, Claude

2017-12-01

The topology and creation energy of domain walls in different magnetic chains (called Single-Chain Magnets or SCMs) are discussed. As these domain walls, that can be seen as "defects", are known to control both static and dynamic properties of these one-dimensional systems, their study and understanding are necessary first steps before a deeper discussion of the SCM properties at finite temperature. The starting point of the paper is the simple regular ferromagnetic chain for which the characteristics of the domain walls are well known. Then two cases will be discussed (i) the "mixed chains" in which isotropic and anisotropic classical spins alternate, and (ii) the so-called "canted chains" where two different easy axis directions are present. In particular, we show that "strictly narrow" domain walls no longer exist in these more complex cases, while a cascade of phase transitions is found for canted chains as the canting angle approaches 45∘. The consequence for thermodynamic properties is briefly discussed in the last part of the paper.

Architecture for time or transform domain decoding of reed-solomon codes

Science.gov (United States)

Shao, Howard M. (Inventor); Truong, Trieu-Kie (Inventor); Hsu, In-Shek (Inventor); Deutsch, Leslie J. (Inventor)

1989-01-01

Two pipeline (255,233) RS decoders, one a time domain decoder and the other a transform domain decoder, use the same first part to develop an errata locator polynomial .tau.(x), and an errata evaluator polynominal A(x). Both the time domain decoder and transform domain decoder have a modified GCD that uses an input multiplexer and an output demultiplexer to reduce the number of GCD cells required. The time domain decoder uses a Chien search and polynomial evaluator on the GCD outputs .tau.(x) and A(x), for the final decoding steps, while the transform domain decoder uses a transform error pattern algorithm operating on .tau.(x) and the initial syndrome computation S(x), followed by an inverse transform algorithm in sequence for the final decoding steps prior to adding the received RS coded message to produce a decoded output message.

The method of images and Green's function for spherical domains

International Nuclear Information System (INIS)

Gutkin, Eugene; Newton, Paul K

2004-01-01

Motivated by problems in electrostatics and vortex dynamics, we develop two general methods for constructing Green's function for simply connected domains on the surface of the unit sphere. We prove a Riemann mapping theorem showing that such domains can be conformally mapped to the upper hemisphere. We then categorize all domains on the sphere for which Green's function can be constructed by an extension of the classical method of images. We illustrate our methods by several examples, such as the upper hemisphere, geodesic triangles, and latitudinal rectangles. We describe the point vortex motion in these domains, which is governed by a Hamiltonian determined by the Dirichlet Green's function

Domain specific MT in use

DEFF Research Database (Denmark)

Offersgaard, Lene; Povlsen, Claus; Almsten, Lisbeth Kjeldgaard

2008-01-01

point scale evaluate the sentence from the point of view of the post-editor. The post-editor profile defined by the LSP is based on the experiences of introducing MT in the LSP workflow. The relation between the Translation Edit Rate (TER) scores and “Usability” scores is tested. We find TER a candidate......The paper focuses on domain specific use of MT with a special focus on SMT in the workflow of a Language Service Provider (LSP). We report on the feedback of post-editors using fluency/adequacy evaluation and the evaluation metric ’Usability’, understood in this context as where users on a three...

High-capacity method for hiding data in the discrete cosine transform domain

Science.gov (United States)

Qazanfari, Kazem; Safabakhsh, Reza

2013-10-01

Steganography is the art and science of hiding data in different media such as texts, audios, images, and videos. Data hiding techniques are generally divided into two groups: spatial and frequency domain techniques. Spatial domain methods generally have low security and, as a result, are less attractive to researchers. Discrete cosine transform (DCT) is the most common transform domain used in steganography and JPEG compression. Since a large number of the DCT coefficients of JPEG images are zero, the capacity of DCT domain-based steganography methods is not very high. We present a high-capacity method for hiding messages in the DCT domain. We describe the method in two classes where the receiver has and where the receiver does not have the cover image. In each class, we consider three cases for each coefficient. By considering n coefficients, there are 3n different situations. The method embeds ⌊log2 3n⌋ bits in these n coefficients. We show that the maximum reachable capacity by our method is 58% higher than the other general steganography methods. Experimental results show that the histogram-based steganalysis methods cannot detect the stego images produced by the proposed method while the capacity is increased significantly.

SharePoint User's Guide

CERN Document Server

Corporation, Infusion Development

2009-01-01

This straightforward guide shows SharePoint users how to create and use web sites for sharing and collaboration. Learn to use the document and picture libraries for adding and editing content, add discussion boards and surveys, receive alerts when documents and information have been added or changed, and enhance security. Designed to help you find answers quickly, the book shows how to make the most of SharePoint for productivity and collaboration.

Implicit function with natural behavior over entire domain

International Nuclear Information System (INIS)

Itoh, Taku; Saitoh, Ayumu; Kamitani, Atsushi; Nakamura, Hiroaki

2012-01-01

To generate a smooth implicit function that behaves naturally over an entire domain, a method to smoothly combine an implicit function f(x) with a global support function g(x) has been proposed. The proposed method can be applied to large scattered point data, since the implicit function f(x) is generated by a partition-of-unity-based method. The global support function g(x) is generated by a radial basis function-based method or by the least-squares method. To ensure a smooth combination of f(x) and g(x), an appropriate weight function is employed. In numerical experiments, the proposed method is applied to large point data. The results illustrate that the proposed method can generate a smooth implicit function F(x) with natural behavior over the entire domain. In addition, on the given points, the accuracy of F(x) is exactly the same as that of f(x). Furthermore, the computational cost for generation of F(x) is almost the same as that of f(x). (author)

On the Technology Roadmap of Free-Viewpoint 3DTV Receivers

NARCIS (Netherlands)

Bondarev, E.; Miquel, R.; Imbert, M.; Zinger, S.; With, de P.H.N.

2011-01-01

This paper presents the architecture of an innovative 3DTV receiver system, enabling Free-ViewPoint (FVP) interpolation and rendering functionality. We outline the hardware architecture of the receiver, and specify how the design decisions address the extremely high processing requirements of the

Ethics in Knowledge Organization: Two Conferences Point to a New Core in the Domain

Directory of Open Access Journals (Sweden)

Richard P. Smiraglia

2015-01-01

Full Text Available http://dx.doi.org/10.5007/1518-2924.2015v20nesp1p1 Two conferences called "Ethics in Information Organization (EIO," held in 2009 and 2013, brought together practitioners and scholars in knowledge organization (KO to discuss ethical decision-making for the organization of knowledge. Traditionally the notion of ethics as a component of knowledge organization has occupied a sort of background position. Concepts of cultural warrant clash with concepts of literary warrant to produce harmful knowledge organization systems. Here tools of domain analytical visualization are applied to the two EIO conferences to demonstrate the potential intension of ethics for KO. Co-word analysis helps to visualize the thematic core in the most frequently used terms: user, ethical, knowledge, national, description, and access. There clearly is a meta-level trajectory incorporating ethics and the user, while the intension includes all applied approaches to KO as well as strong recognition of national, regional, and social cultural identities. Another approach to domain analysis is to examine the social semantics (by analyzing the public record of discourse through citation patterns. Author co-citation analysis shows work anchored in the basic theoretical premises of KO, but also bringing ideas from outside the domain to bear on the problems of objective violence. A network visualization shows how the work on ethics in KO is based on the core principles of KO, but relies also on evidence from librarianship and philosophical guidance to bring forward the issues surrounding objective violence in KOS. The authors contributing to this small pair of conferences have laid out a pathway for expanding understanding of the role of ethics in KO.

Structural domain walls in polar hexagonal manganites

Science.gov (United States)

Kumagai, Yu

2014-03-01

The domain structure in the multiferroic hexagonal manganites is currently intensely investigated, motivated by the observation of intriguing sixfold topological defects at their meeting points [Choi, T. et al,. Nature Mater. 9, 253 (2010).] and nanoscale electrical conductivity at the domain walls [Wu, W. et al., Phys. Rev. Lett. 108, 077203 (2012).; Meier, D. et al., Nature Mater. 11, 284 (2012).], as well as reports of coupling between ferroelectricity, magnetism and structural antiphase domains [Geng, Y. et al., Nano Lett. 12, 6055 (2012).]. The detailed structure of the domain walls, as well as the origin of such couplings, however, was previously not fully understood. In the present study, we have used first-principles density functional theory to calculate the structure and properties of the low-energy structural domain walls in the hexagonal manganites [Kumagai, Y. and Spaldin, N. A., Nature Commun. 4, 1540 (2013).]. We find that the lowest energy domain walls are atomically sharp, with {210}orientation, explaining the orientation of recently observed stripe domains and suggesting their topological protection [Chae, S. C. et al., Phys. Rev. Lett. 108, 167603 (2012).]. We also explain why ferroelectric domain walls are always simultaneously antiphase walls, propose a mechanism for ferroelectric switching through domain-wall motion, and suggest an atomistic structure for the cores of the sixfold topological defects. This work was supported by ETH Zurich, the European Research Council FP7 Advanced Grants program me (grant number 291151), the JSPS Postdoctoral Fellowships for Research Abroad, and the MEXT Elements Strategy Initiative to Form Core Research Center TIES.

Monopoles, vortices, domain walls and D-branes: The rules of interaction

International Nuclear Information System (INIS)

Sakai, Norisuke; Tong, David

2005-01-01

Non-abelian gauge theories in the Higgs phase admit a startling variety of BPS solitons. These include domain walls, vortex strings, confined monopoles threaded on vortex strings, vortex strings ending on domain walls, monopoles threaded on strings ending on domain walls, and more. After presenting a self-contained review of these objects, including several new results on the dynamics of domain walls, we go on to examine the possible interactions of solitons of various types. We point out the existence of a classical binding energy when the string ends on the domain wall which can be thought of as a BPS boojum with negative mass. We present an index theorem for domain walls in non-abelian gauge theories. We also answer questions such as: Which strings can end on which walls? What happens when monopoles pass through domain walls? What happens when domain walls pass through each other? (author)

Performance of Closely Spaced Point Absorbers with Constrained Floater Motion

DEFF Research Database (Denmark)

De Backer, G.; Vantorre, M.; Beels, C.

2009-01-01

The performance of a wave energy converter array of twelve heaving point absorbers has been assessed numerically in a frequency domain model. Each point absorber is assumed to have its own linear power take-off. The impact of slamming, stroke and force restrictions on the power absorption...

Infrared maritime target detection using a probabilistic single Gaussian model of sea clutter in Fourier domain

Science.gov (United States)

Zhou, Anran; Xie, Weixin; Pei, Jihong; Chen, Yapei

2018-02-01

For ship targets detection in cluttered infrared image sequences, a robust detection method, based on the probabilistic single Gaussian model of sea background in Fourier domain, is put forward. The amplitude spectrum sequences at each frequency point of the pure seawater images in Fourier domain, being more stable than the gray value sequences of each background pixel in the spatial domain, are regarded as a Gaussian model. Next, a probability weighted matrix is built based on the stability of the pure seawater's total energy spectrum in the row direction, to make the Gaussian model more accurate. Then, the foreground frequency points are separated from the background frequency points by the model. Finally, the false-alarm points are removed utilizing ships' shape features. The performance of the proposed method is tested by visual and quantitative comparisons with others.

A Model of Inter and Multi Disciplinary Domains, and their Mutual Interactions

Directory of Open Access Journals (Sweden)

Ophir Dan

2014-02-01

Full Text Available The Melvil Dewey Decimal Classification system maps the human knowledge domains into a library classification decimal system, which means that the knowledge is discretized. The domains are countable similarly to how Cantor proved the countability of the fractions' domain. The debate about the "inter-" and "multi-" disciplinary domains may also be extended into "sub-domains" or from another point of view – into "super-domains". However, Science and Technology has rapidly developed after it was classified. If at the beginning, two decimal digits were enough to classify the world's knowledge into a knowledge domain, today we need more digits – about five. This means we are able to display about a million domains of knowledge. The decimal point indicates the sub-division in the zooming-in; the number of such decimal points is unlimited. Thus, the number of hierarchical levels in the knowledge-tree is unlimited. The maximal level is unreachable since it propagates in time. This intriguing issue raises doubts whether the tree is the most appropriate structure in the current state of the knowledge classification. However, I believe that the knowledge tree is a convenient way of expressing various connections between the knowledge domains. There are other models such as multi-level graph-networks that approximate closer to reality. These models can be further visualized by graph diagrams. The knowledge diagram is more complicated, considering the interaction between science and industry relative to each domain. The model of reality might be compared to the object-oriented programming languages approximating reality in order to construct more naturally computer programs that can model the world. The mutual correspondence of the knowledge domains is dynamic. Some examples of relatively new domains are as follows: biotechnology, bioinformatics, nanotechnology, integro-differential equations, data warehouse, data mining, requirements engineering, micro

AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA.

Science.gov (United States)

Götz, Frank; Roske, Yvette; Schulz, Maike Svenja; Autenrieth, Karolin; Bertinetti, Daniela; Faelber, Katja; Zühlke, Kerstin; Kreuchwig, Annika; Kennedy, Eileen J; Krause, Gerd; Daumke, Oliver; Herberg, Friedrich W; Heinemann, Udo; Klussmann, Enno

2016-07-01

A-kinase anchoring proteins (AKAPs) interact with the dimerization/docking (D/D) domains of regulatory subunits of the ubiquitous protein kinase A (PKA). AKAPs tether PKA to defined cellular compartments establishing distinct pools to increase the specificity of PKA signalling. Here, we elucidated the structure of an extended PKA-binding domain of AKAP18β bound to the D/D domain of the regulatory RIIα subunits of PKA. We identified three hydrophilic anchor points in AKAP18β outside the core PKA-binding domain, which mediate contacts with the D/D domain. Such anchor points are conserved within AKAPs that bind regulatory RII subunits of PKA. We derived a different set of anchor points in AKAPs binding regulatory RI subunits of PKA. In vitro and cell-based experiments confirm the relevance of these sites for the interaction of RII subunits with AKAP18 and of RI subunits with the RI-specific smAKAP. Thus we report a novel mechanism governing interactions of AKAPs with PKA. The sequence specificity of each AKAP around the anchor points and the requirement of these points for the tight binding of PKA allow the development of selective inhibitors to unequivocally ascribe cellular functions to the AKAP18-PKA and other AKAP-PKA interactions. © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.

Source-receiver two-way wave extrapolation for prestack exploding-reflector modelling and migration

KAUST Repository

Alkhalifah, Tariq Ali; Fomel, Sergey; Wu, Zedong

2014-01-01

or backward in time. This approach has the potential for generating accurate images free of artiefacts associated with conventional approaches. We derive novel high-order partial differential equations in the source-receiver time domain. The fourth

A Probabilistic Graphical Model to Detect Chromosomal Domains

Science.gov (United States)

Heermann, Dieter; Hofmann, Andreas; Weber, Eva

To understand the nature of a cell, one needs to understand the structure of its genome. For this purpose, experimental techniques such as Hi-C detecting chromosomal contacts are used to probe the three-dimensional genomic structure. These experiments yield topological information, consistently showing a hierarchical subdivision of the genome into self-interacting domains across many organisms. Current methods for detecting these domains using the Hi-C contact matrix, i.e. a doubly-stochastic matrix, are mostly based on the assumption that the domains are distinct, thus non-overlapping. For overcoming this simplification and for being able to unravel a possible nested domain structure, we developed a probabilistic graphical model that makes no a priori assumptions on the domain structure. Within this approach, the Hi-C contact matrix is analyzed using an Ising like probabilistic graphical model whose coupling constant is proportional to each lattice point (entry in the contact matrix). The results show clear boundaries between identified domains and the background. These domain boundaries are dependent on the coupling constant, so that one matrix yields several clusters of different sizes, which show the self-interaction of the genome on different scales. This work was supported by a Grant from the International Human Frontier Science Program Organization (RGP0014/2014).

Sectio Aurea Conditions for Mityuk's Radius of Two-Connected Domains

Directory of Open Access Journals (Sweden)

A.V. Kazantsev

2017-03-01

Full Text Available Connection of an exterior inverse boundary value problem with the critical points of some surface is one of the central themes in the theory of exterior inverse boundary value problems for analytic functions. In the simply connected case, such a surface is defined by the inner mapping radius; in the multiply connected one, by the function Ω(w such that M(w = (2π–1ln Ω(w is Mityuk's version of a generalized reduced module. In the present paper, the relation between the curvature of the surface Ω = Ω(w with the Schwarzian derivatives of the mapping functions and with the Bergman kernel functions k0(w,ω and l0(w,ω is established for an arbitrary multiply connected domain. When passing to two-connected domains, due to the choice of the ring as a canonical domain, we construct the conditions for the critical points of Mityuk's radius to concentrate on the golden section circle of the ring. Finally, we show that the minimal collection of the critical points of the Mityuk radius in the two-connected case, consisting of one maximum and one saddle, is attained for the linear-fractional solution of the exterior inverse boundary value problem.

Bit Error Rate Due to Misalignment of Earth Station Antenna Pointing to Satellite

Directory of Open Access Journals (Sweden)

Wahyu Pamungkas

2010-04-01

Full Text Available One problem causing reduction of energy in satellite communications system is the misalignment of earth station antenna pointing to satellite. Error in pointing would affect the quality of information signal to energy bit in earth station. In this research, error in pointing angle occurred only at receiver (Rx antenna, while the transmitter (Tx antennas precisely point to satellite. The research was conducted towards two satellites, namely TELKOM-1 and TELKOM-2. At first, measurement was made by directing Tx antenna precisely to satellite, resulting in an antenna pattern shown by spectrum analyzer. The output from spectrum analyzers is drawn with the right scale to describe swift of azimuth and elevation pointing angle towards satellite. Due to drifting from the precise pointing, it influenced the received link budget indicated by pattern antenna. This antenna pattern shows reduction of power level received as a result of pointing misalignment. As a conclusion, the increasing misalignment of pointing to satellite would affect in the reduction of received signal parameters link budget of down-link traffic.

Evaluation of bispectrum in the wave number domain based on multi-point measurements

Directory of Open Access Journals (Sweden)

Y. Narita

2008-10-01

Full Text Available We present an estimator of the bispectrum, a measure of three-wave couplings. It is evaluated directly in the wave number domain using a limited number of detectors. The ability of the bispectrum estimator is examined numerically and then it is applied to fluctuations of magnetic field and electron density in the terrestrial foreshock region observed by the four Cluster spacecraft, which indicates the presence of a three-wave coupling in space plasma.

Compressed Sensing-Based Direct Conversion Receiver

DEFF Research Database (Denmark)

Pierzchlewski, Jacek; Arildsen, Thomas; Larsen, Torben

2012-01-01

Due to the continuously increasing computational power of modern data receivers it is possible to move more and more processing from the analog to the digital domain. This paper presents a compressed sensing approach to relaxing the analog filtering requirements prior to the ADCs in a direct......-converted radio signals. As shown in an experiment presented in the article, when the proposed method is used, it is possible to relax the requirements for the quadrature down-converter filters. A random sampling device and an additional digital signal processing module is the price to pay for these relaxed...

Moho map of South America from receiver functions and surface waves

Science.gov (United States)

Lloyd, Simon; van der Lee, Suzan; FrançA, George Sand; AssumpçãO, Marcelo; Feng, Mei

2010-11-01

We estimate crustal structure and thickness of South America north of roughly 40°S. To this end, we analyzed receiver functions from 20 relatively new temporary broadband seismic stations deployed across eastern Brazil. In the analysis we include teleseismic and some regional events, particularly for stations that recorded few suitable earthquakes. We first estimate crustal thickness and average Poisson's ratio using two different stacking methods. We then combine the new crustal constraints with results from previous receiver function studies. To interpolate the crustal thickness between the station locations, we jointly invert these Moho point constraints, Rayleigh wave group velocities, and regional S and Rayleigh waveforms for a continuous map of Moho depth. The new tomographic Moho map suggests that Moho depth and Moho relief vary slightly with age within the Precambrian crust. Whether or not a positive correlation between crustal thickness and geologic age is derived from the pre-interpolation point constraints depends strongly on the selected subset of receiver functions. This implies that using only pre-interpolation point constraints (receiver functions) inadequately samples the spatial variation in geologic age. The new Moho map also reveals an anomalously deep Moho beneath the oldest core of the Amazonian Craton.

Identifying Domain-General and Domain-Specific Predictors of Low Mathematics Performance: A Classification and Regression Tree Analysis

Directory of Open Access Journals (Sweden)

David J. Purpura

2017-12-01

Full Text Available Many children struggle to successfully acquire early mathematics skills. Theoretical and empirical evidence has pointed to deficits in domain-specific skills (e.g., non-symbolic mathematics skills or domain-general skills (e.g., executive functioning and language as underlying low mathematical performance. In the current study, we assessed a sample of 113 three- to five-year old preschool children on a battery of domain-specific and domain-general factors in the fall and spring of their preschool year to identify Time 1 (fall factors associated with low performance in mathematics knowledge at Time 2 (spring. We used the exploratory approach of classification and regression tree analyses, a strategy that uses step-wise partitioning to create subgroups from a larger sample using multiple predictors, to identify the factors that were the strongest classifiers of low performance for younger and older preschool children. Results indicated that the most consistent classifier of low mathematics performance at Time 2 was children’s Time 1 mathematical language skills. Further, other distinct classifiers of low performance emerged for younger and older children. These findings suggest that risk classification for low mathematics performance may differ depending on children’s age.

Feasibility and Domain Validation of Rheumatoid Arthritis (RA) Flare Core Domain Set

DEFF Research Database (Denmark)

Bartlett, Susan J; Bykerk, Vivian P; Cooksey, Roxanne

2015-01-01

, and stiffness scores averaged ≥ 2 times higher (2 of 11 points) in flaring individuals. Correlations between flare domains and corresponding legacy instruments were obtained: r = 0.46 to 0.93. A combined definition (patient report of flare and 28-joint Disease Activity Score increase) was evaluated in 2 other...... provided input for stiffness, self-management, contextual factors, and measurement considerations. RESULTS: Flare data from 501 patients in an observational study indicated 39% were in flare, with mean (SD) severity of 6.0 (2.6) and 55% lasting > 14 days. Pain, physical function, fatigue, participation...

Microscopic return point memory in Co/Pd multilayer films

Energy Technology Data Exchange (ETDEWEB)

Seu, K.A.; Su, R.; Roy, S.; Parks, D.; Shipton, E.; Fullerton, E.E.; Kevan, S.D.

2009-10-01

We report soft x-ray speckle metrology measurements of microscopic return point and complementary point memory in Co/Pd magnetic films having perpendicular anisotropy. We observe that the domains assemble into a common labyrinth phase with a period that varies by nearly a factor of two between initial reversal and fields near saturation. Unlike previous studies of similar systems, the ability of the film to reproduce its domain structure after magnetic cycling through saturation varies from loop to loop, from position to position on the sample, and with the part of the speckle pattern used in the metrology measurements. We report the distribution of memory as a function of field and discuss these results in terms of the reversal process.

Analog fourier transform channelizer and OFDM receiver

OpenAIRE

2007-01-01

An OFDM receiver having an analog multiplier based I-Q channelizing filter, samples and holds consecutive analog I-Q samples of an I-Q baseband, the I-Q basebands having OFDM sub-channels. A lattice of analog I-Q multipliers and analog I-Q summers concurrently receives the held analog I-Q samples, performs analog I-Q multiplications and analog I-Q additions to concurrently generate a plurality of analog I-Q output signals, representing an N-point discrete Fourier transform of the held analog ...

FHA domains as phospho-threonine binding modules in cell signaling.

Science.gov (United States)

Hammet, Andrew; Pike, Brietta L; McNees, Carolyn J; Conlan, Lindus A; Tenis, Nora; Heierhorst, Jörg

2003-01-01

Forkhead-associated (FHA) domains are present in >200 diverse proteins in all phyla from bacteria to mammals and seem to be particularly prevalent in proteins with cell cycle control functions. Recent work from several laboratories has considerably improved our understanding of the structure and function of these domains that were virtually unknown a few years ago, and the first disease associations of FHA domains have now emerged. FHA domains form 11-stranded beta-sandwiches that contain some 100-180 amino acid residues with a high degree of sequence diversity. FHA domains act as phosphorylation-dependent protein-protein interaction modules that preferentially bind to phospho-threonine residues in their targets. Interestingly, point mutations in the human CHK2 gene that lead to single-residue amino acid substitutions in the FHA domain of this cell cycle checkpoint kinase have been found to cause a subset of cases of the Li-Fraumeni multi-cancer syndrome.

Robust exponential stability and domains of attraction in a class of interval neural networks

International Nuclear Information System (INIS)

Yang Xiaofan; Liao Xiaofeng; Bai Sen; Evans, David J

2005-01-01

This paper addresses robust exponential stability as well as domains of attraction in a class of interval neural networks. A sufficient condition for an equilibrium point to be exponentially stable is established. And an estimate on the domains of attraction of exponentially stable equilibrium points is presented. Both the condition and the estimate are formulated in terms of the parameter intervals, the neurons' activation functions and the equilibrium point. Hence, they are easily checkable. In addition, our results neither depend on monotonicity of the activation functions nor on coupling conditions between the neurons. Consequently, these results are of practical importance in evaluating the performance of interval associative memory networks

Fabrication of Detector Arrays for the SPT-3G Receiver

Science.gov (United States)

Posada, C. M.; Ade, P. A. R.; Ahmed, Z.; Anderson, A. J.; Austermann, J. E.; Avva, J. S.; Thakur, R. Basu; Bender, A. N.; Benson, B. A.; Carlstrom, J. E.; Carter, F. W.; Cecil, T.; Chang, C. L.; Cliche, J. F.; Cukierman, A.; Denison, E. V.; de Haan, T.; Ding, J.; Divan, R.; Dobbs, M. A.; Dutcher, D.; Everett, W.; Foster, A.; Gannon, R. N.; Gilbert, A.; Groh, J. C.; Halverson, N. W.; Harke-Hosemann, A. H.; Harrington, N. L.; Henning, J. W.; Hilton, G. C.; Holzapfel, W. L.; Huang, N.; Irwin, K. D.; Jeong, O. B.; Jonas, M.; Khaire, T.; Kofman, A. M.; Korman, M.; Kubik, D.; Kuhlmann, S.; Kuo, C. L.; Lee, A. T.; Lowitz, A. E.; Meyer, S. S.; Michalik, D.; Miller, C. S.; Montgomery, J.; Nadolski, A.; Natoli, T.; Nguyen, H.; Noble, G. I.; Novosad, V.; Padin, S.; Pan, Z.; Pearson, J.; Rahlin, A.; Ruhl, J. E.; Saunders, L. J.; Sayre, J. T.; Shirley, I.; Shirokoff, E.; Smecher, G.; Sobrin, J. A.; Stan, L.; Stark, A. A.; Story, K. T.; Suzuki, A.; Tang, Q. Y.; Thompson, K. L.; Tucker, C.; Vale, L. R.; Vanderlinde, K.; Vieira, J. D.; Wang, G.; Whitehorn, N.; Yefremenko, V.; Yoon, K. W.; Young, M. R.

2018-05-01

The South Pole Telescope third-generation (SPT-3G) receiver was installed during the austral summer of 2016-2017. It is designed to measure the cosmic microwave background across three frequency bands centered at 95, 150, and 220 GHz. The SPT-3G receiver has ten focal plane modules, each with 269 pixels. Each pixel features a broadband sinuous antenna coupled to a niobium microstrip transmission line. In-line filters define the desired band-passes before the signal is coupled to six bolometers with Ti/Au/Ti/Au transition edge sensors (three bands × two polarizations). In total, the SPT-3G receiver is composed of 16,000 detectors, which are read out using a 68× frequency-domain multiplexing scheme. In this paper, we present the process employed in fabricating the detector arrays.

Charm physics with physical light and strange quarks using domain wall fermions

CERN Document Server

Boyle, Peter A; Garron, Nicolas; Khamseh, Ava; Marinkovic, Marina; Sanfilippo, Francesco; Tsang, Justus Tobias; Boyle, Peter A.

2015-01-01

We present a study of charm physics using RBC/UKQCD 2+1 flavour physical point domain wall fermion ensembles for the light quarks as well as for the valence charm quark. After a brief motivation of domain wall fermions as a suitable heavy quark discretisation we will show first results for masses and matrix elements.

Solutions to second order non-homogeneous multi-point BVPs using a fixed-point theorem

Directory of Open Access Journals (Sweden)

Yuji Liu

2008-07-01

Full Text Available In this article, we study five non-homogeneous multi-point boundary-value problems (BVPs of second order differential equations with the one-dimensional p-Laplacian. These problems have a common equation (in different function domains and different boundary conditions. We find conditions that guarantee the existence of at least three positive solutions. The results obtained generalize several known ones and are illustrated by examples. It is also shown that the approach for getting three positive solutions by using multi-fixed-point theorems can be extended to nonhomogeneous BVPs. The emphasis is on the nonhomogeneous boundary conditions and the nonlinear term involving first order derivative of the unknown. Some open problems are also proposed.

Beyond cross-domain learning: Multiple-domain nonnegative matrix factorization

KAUST Repository

Wang, Jim Jing-Yan; Gao, Xin

2014-01-01

Traditional cross-domain learning methods transfer learning from a source domain to a target domain. In this paper, we propose the multiple-domain learning problem for several equally treated domains. The multiple-domain learning problem assumes that samples from different domains have different distributions, but share the same feature and class label spaces. Each domain could be a target domain, while also be a source domain for other domains. A novel multiple-domain representation method is proposed for the multiple-domain learning problem. This method is based on nonnegative matrix factorization (NMF), and tries to learn a basis matrix and coding vectors for samples, so that the domain distribution mismatch among different domains will be reduced under an extended variation of the maximum mean discrepancy (MMD) criterion. The novel algorithm - multiple-domain NMF (MDNMF) - was evaluated on two challenging multiple-domain learning problems - multiple user spam email detection and multiple-domain glioma diagnosis. The effectiveness of the proposed algorithm is experimentally verified. © 2013 Elsevier Ltd. All rights reserved.

Beyond cross-domain learning: Multiple-domain nonnegative matrix factorization

KAUST Repository

Wang, Jim Jing-Yan

2014-02-01

Traditional cross-domain learning methods transfer learning from a source domain to a target domain. In this paper, we propose the multiple-domain learning problem for several equally treated domains. The multiple-domain learning problem assumes that samples from different domains have different distributions, but share the same feature and class label spaces. Each domain could be a target domain, while also be a source domain for other domains. A novel multiple-domain representation method is proposed for the multiple-domain learning problem. This method is based on nonnegative matrix factorization (NMF), and tries to learn a basis matrix and coding vectors for samples, so that the domain distribution mismatch among different domains will be reduced under an extended variation of the maximum mean discrepancy (MMD) criterion. The novel algorithm - multiple-domain NMF (MDNMF) - was evaluated on two challenging multiple-domain learning problems - multiple user spam email detection and multiple-domain glioma diagnosis. The effectiveness of the proposed algorithm is experimentally verified. © 2013 Elsevier Ltd. All rights reserved.

Creativity as Action: Findings from Five Creative Domains

Directory of Open Access Journals (Sweden)

Vlad eGlaveanu

2013-04-01

Full Text Available The present paper outlines an action theory of creativity and substantiates this approach by investigating creative expression in five different domains. We propose an action framework for the analysis of creative acts built on the assumption that creativity is a relational, inter-subjective phenomenon. This framework, drawing extensively from the work of Dewey (1934 on art as experience, is used to derive a coding frame for the analysis of interview material. The article reports findings from the analysis of 60 interviews with recognised French creators in five creative domains: art, design, science, scriptwriting, and music. Results point to complex models of action and inter-action specific for each domain and also to interesting patterns of similarity and differences between domains. These findings highlight the fact that creative action takes place not ‘inside’ individual creators but ‘in between’ actors and their environment. Implications for the field of educational psychology are discussed.

Study of time dependence and spectral composition of the signal in circuit of ac electric point motors

Directory of Open Access Journals (Sweden)

S. Yu. Buryak

2014-12-01

Full Text Available Purpose. The paper is aimed to establish the dependence of changes in the time domain and spectral components of the current in the circuit of the AC electric point motor on its technical condition, to identify the common features for the same type of damage. It is necessary using the analysis of the received signals to carry out the remote diagnosis and determination of faults and defects of electric point motors. In addition it suggested to accelerate the process of the failure, malfunction and damage search. Authors propose the automated approach to the service of remote floor automation equipment, which is located in the envelope of trains. Reduction of the threat to life and health of staff by reducing the residence time in the zone of train movement. Reduce the impact of human factors on the result of service. Methodology. The paper studies the structure, parameters and characteristics, the operation and maintenance characteristics of the AC electric point motors. Determination of the main types of possible faults in the process depending on the operating conditions. Presentation of the electric motor as an object of diagnosis. Findings. The time dependences of the current in the circuit of electric point motor for its various states was obtained. The connection between the technical condition of electric point motor and the performance of current curve in time and spectral domains was established. The revealed deviations from the reference signal were justified. According to the obtained results it was made the conclusion. Originality. A method for diagnosing the state of the AC electric point motor by the time dependence and the spectral composition of the current in its circuit was proposed. The connection diagram to the motor windings based on non-infringement of electric parameters of connection circuit in the actual operating conditions was applied. Practical value. The obtained results suggest the possibility and feasibility of

Adaptation of interoperability standards for cross domain usage

Science.gov (United States)

Essendorfer, B.; Kerth, Christian; Zaschke, Christian

2017-05-01

As globalization affects most aspects of modern life, challenges of quick and flexible data sharing apply to many different domains. To protect a nation's security for example, one has to look well beyond borders and understand economical, ecological, cultural as well as historical influences. Most of the time information is produced and stored digitally and one of the biggest challenges is to receive relevant readable information applicable to a specific problem out of a large data stock at the right time. These challenges to enable data sharing across national, organizational and systems borders are known to other domains (e.g., ecology or medicine) as well. Solutions like specific standards have been worked on for the specific problems. The question is: what can the different domains learn from each other and do we have solutions when we need to interlink the information produced in these domains? A known problem is to make civil security data available to the military domain and vice versa in collaborative operations. But what happens if an environmental crisis leads to the need to quickly cooperate with civil or military security in order to save lives? How can we achieve interoperability in such complex scenarios? The paper introduces an approach to adapt standards from one domain to another and lines out problems that have to be overcome and limitations that may apply.

Border collisions inside the stability domain of a fixed point

DEFF Research Database (Denmark)

Avrutin, Viktor; Zhusubaliyev, Zhanybai T.; Mosekilde, Erik

2016-01-01

a complicated interior structure formed by boundaries defined by persistence border collisions. We describe a simple approach that is based on symbolic dynamics and makes it possible to detect such boundaries numerically. Using this approach we describe several regions in the parameter space leading......Recent studies on a power electronic DC/AC converter (inverter) have demonstrated that such systems may undergo a transition from regular dynamics (associated with a globally attracting fixed point of a suitable stroboscopic map) to chaos through an irregular sequence of border-collision events...

Conceptual model of the globalization for domain-specific languages

NARCIS (Netherlands)

Clark, T.; van den Brand, M.; Combemale, B.; Rumpe, B.; Combemale, B.

2015-01-01

Domain Specific Languages (DSL) have received some prominence recently. Designing a DSL and all their tools is still cumbersome and lots of work. Engineering of DSLs is still at infancy, not even the terms have been coined and agreed on. In particular globalization and all its consequences need to

Post-Processing in the Material-Point Method

DEFF Research Database (Denmark)

Andersen, Søren; Andersen, Lars Vabbersgaard

The material-point method (MPM) is a numerical method for dynamic or static analysis of solids using a discretization in time and space. The method has shown to be successful in modelling physical problems involving large deformations, which are difficult to model with traditional numerical tools...... such as the finite element method. In the material-point method, a set of material points is utilized to track the problem in time and space, while a computational background grid is utilized to obtain spatial derivatives relevant to the physical problem. Currently, the research within the material-point method......-point method. The first idea involves associating a volume with each material point and displaying the deformation of this volume. In the discretization process, the physical domain is divided into a number of smaller volumes each represented by a simple shape; here quadrilaterals are chosen for the presented...

Classical solutions of mixed problems for quasilinear first order PFDEs on a cylindrical domain

Directory of Open Access Journals (Sweden)

Wojciech Czernous

2014-01-01

Full Text Available We abandon the setting of the domain as a Cartesian product of real intervals, customary for first order PFDEs (partial functional differential equations with initial boundary conditions. We give a new set of conditions on the possibly unbounded domain \\(\\Omega\\ with Lipschitz differentiable boundary. Well-posedness is then reliant on a variant of the normal vector condition. There is a neighbourhood of \\(\\partial\\Omega\\ with the property that if a characteristic trajectory has a point therein, then its every earlier point lies there as well. With local assumptions on coefficients and on the free term, we prove existence and Lipschitz dependence on data of classical solutions on \\((0,c\\times\\Omega\\ to the initial boundary value problem, for small \\(c\\. Regularity of solutions matches this domain, and the proof uses the Banach fixed-point theorem. Our general model of functional dependence covers problems with deviating arguments and integro-differential equations.

Neutron transport solver parallelization using a Domain Decomposition method

International Nuclear Information System (INIS)

Van Criekingen, S.; Nataf, F.; Have, P.

2008-01-01

A domain decomposition (DD) method is investigated for the parallel solution of the second-order even-parity form of the time-independent Boltzmann transport equation. The spatial discretization is performed using finite elements, and the angular discretization using spherical harmonic expansions (P N method). The main idea developed here is due to P.L. Lions. It consists in having sub-domains exchanging not only interface point flux values, but also interface flux 'derivative' values. (The word 'derivative' is here used with quotes, because in the case considered here, it in fact consists in the Ω.∇ operator, with Ω the angular variable vector and ∇ the spatial gradient operator.) A parameter α is introduced, as proportionality coefficient between point flux and 'derivative' values. This parameter can be tuned - so far heuristically - to optimize the method. (authors)

Quadratic polynomial interpolation on triangular domain

Science.gov (United States)

Li, Ying; Zhang, Congcong; Yu, Qian

2018-04-01

In the simulation of natural terrain, the continuity of sample points are not in consonance with each other always, traditional interpolation methods often can't faithfully reflect the shape information which lie in data points. So, a new method for constructing the polynomial interpolation surface on triangular domain is proposed. Firstly, projected the spatial scattered data points onto a plane and then triangulated them; Secondly, A C1 continuous piecewise quadric polynomial patch was constructed on each vertex, all patches were required to be closed to the line-interpolation one as far as possible. Lastly, the unknown quantities were gotten by minimizing the object functions, and the boundary points were treated specially. The result surfaces preserve as many properties of data points as possible under conditions of satisfying certain accuracy and continuity requirements, not too convex meantime. New method is simple to compute and has a good local property, applicable to shape fitting of mines and exploratory wells and so on. The result of new surface is given in experiments.

Experimentally achieving borehole antenna radar directivity in the time domain in the presence of strong mutual coupling

CSIR Research Space (South Africa)

Vogt, D

2008-06-01

Full Text Available published borehole radar antennas have achieved directivity by post processing data received in the frequency domain, or by constructing an aperture antenna, where borehole dimensions allowed this. In this paper, a time-domain technique is investigated...

Critical Point in Self-Organized Tissue Growth

Science.gov (United States)

Aguilar-Hidalgo, Daniel; Werner, Steffen; Wartlick, Ortrud; González-Gaitán, Marcos; Friedrich, Benjamin M.; Jülicher, Frank

2018-05-01

We present a theory of pattern formation in growing domains inspired by biological examples of tissue development. Gradients of signaling molecules regulate growth, while growth changes these graded chemical patterns by dilution and advection. We identify a critical point of this feedback dynamics, which is characterized by spatially homogeneous growth and proportional scaling of patterns with tissue length. We apply this theory to the biological model system of the developing wing of the fruit fly Drosophila melanogaster and quantitatively identify signatures of the critical point.

Receiver function structure beneath a broad-band seismic station in south Sumatra

Science.gov (United States)

MacPherson, K. A.; Hidayat, D.; Goh, S.

2010-12-01

We estimated the one-dimensional velocity structure beneath a broad-band station in south Sumatra by the forward modeling and inversion of receiver functions. Station PMBI belongs to the GEOFON seismic network maintained by GFZ-Potsdam, and at a longitude of 104.77° and latitude of -2.93°, sits atop the south Sumatran basin. This station is of interest to researchers at the Earth Observatory of Singapore, as data from it and other stations in Sumatra and Singapore will be incorporated into a regional velocity model for use in seismic hazard analyses. Three-component records from 193 events at teleseismic distances and Mw ≥ 5.0 were examined for this study and 67 records were deemed to have sufficient signal to noise characteristics to be retained for analysis. Observations are primarily from source zones in the Bougainville trench with back-azimuths to the east-south-east, the Japan and Kurile trenches with back-azimuths to the northeast, and a scattering of observations from other azimuths. Due to the level of noise present in even the higher-quality records, the usual frequency-domain deconvolution method of computing receiver functions was ineffective, and a time-domain iterative deconvolution was employed to obtain usable wave forms. Receiver functions with similar back-azimuths were stacked in order to improve their signal to noise ratios. The resulting wave forms are relatively complex, with significant energy being present in the tangential components, indicating heterogeneity in the underlying structure. A dip analysis was undertaken but no clear pattern was observed. However, it is apparent that polarities of the tangential components were generally reversed for records that sample the Sunda trench. Forward modeling of the receiver functions indicates the presence of a near-surface low-velocity layer (Vp≈1.9 km/s) and a Moho depth of ~31 km. Details of the crustal structure were investigated by employing time-domain inversions of the receiver

Gaining industrial confidence for the introduction of domain-specific languages

NARCIS (Netherlands)

Mooij, A.J.; Hooman, J.; Albers, R.

2013-01-01

Domain-Specific Languages (DSLs) receive attention as the possible next abstraction step in programming. Despite the benefits of using DSLs, in the industry there is also some reluctance against their introduction in product development. We address a number of issues that are important to gain

An information theory framework for dynamic functional domain connectivity.

Science.gov (United States)

Vergara, Victor M; Miller, Robyn; Calhoun, Vince

2017-06-01

Dynamic functional network connectivity (dFNC) analyzes time evolution of coherent activity in the brain. In this technique dynamic changes are considered for the whole brain. This paper proposes an information theory framework to measure information flowing among subsets of functional networks call functional domains. Our method aims at estimating bits of information contained and shared among domains. The succession of dynamic functional states is estimated at the domain level. Information quantity is based on the probabilities of observing each dynamic state. Mutual information measurement is then obtained from probabilities across domains. Thus, we named this value the cross domain mutual information (CDMI). Strong CDMIs were observed in relation to the subcortical domain. Domains related to sensorial input, motor control and cerebellum form another CDMI cluster. Information flow among other domains was seldom found. Other methods of dynamic connectivity focus on whole brain dFNC matrices. In the current framework, information theory is applied to states estimated from pairs of multi-network functional domains. In this context, we apply information theory to measure information flow across functional domains. Identified CDMI clusters point to known information pathways in the basal ganglia and also among areas of sensorial input, patterns found in static functional connectivity. In contrast, CDMI across brain areas of higher level cognitive processing follow a different pattern that indicates scarce information sharing. These findings show that employing information theory to formally measured information flow through brain domains reveals additional features of functional connectivity. Copyright © 2017 Elsevier B.V. All rights reserved.

BOUNDARY VALUE PROBLEM FOR A LOADED EQUATION ELLIPTIC-HYPERBOLIC TYPE IN A DOUBLY CONNECTED DOMAIN

Directory of Open Access Journals (Sweden)

O.Kh. Abdullaev

2014-06-01

Full Text Available We study the existence and uniqueness of the solution of one boundary value problem for the loaded elliptic-hyperbolic equation of the second order with two lines of change of type in double-connected domain. Similar results have been received by D.M.Kuryhazov, when investigated domain is one-connected.

Transmit/Receive Spatial Smoothing with Improved Effective Array Aperture for Angle and Mutual Coupling Estimation in Bistatic MIMO Radar

Directory of Open Access Journals (Sweden)

Haomiao Liu

2016-01-01

Full Text Available We proposed a transmit/receive spatial smoothing with improved effective aperture approach for angle and mutual coupling estimation in bistatic MIMO radar. Firstly, the noise in each channel is restrained, by exploiting its independency, in both the spatial domain and temporal domain. Then the augmented transmit and receive spatial smoothing matrices with improved effective aperture are obtained, by exploiting the Vandermonde structure of steering vector with uniform linear array. The DOD and DOA can be estimated by utilizing the unitary ESPRIT algorithm. Finally, the mutual coupling coefficients of both the transmitter and the receiver can be figured out with the estimated angles of DOD and DOA. Numerical examples are presented to verify the effectiveness of the proposed method.

The Radiation Problem from a Vertical Hertzian Dipole Antenna above Flat and Lossy Ground: Novel Formulation in the Spectral Domain with Closed-Form Analytical Solution in the High Frequency Regime

Directory of Open Access Journals (Sweden)

K. Ioannidi

2014-01-01

Full Text Available We consider the problem of radiation from a vertical short (Hertzian dipole above flat lossy ground, which represents the well-known “Sommerfeld radiation problem” in the literature. The problem is formulated in a novel spectral domain approach, and by inverse three-dimensional Fourier transformation the expressions for the received electric and magnetic (EM field in the physical space are derived as one-dimensional integrals over the radial component of wavevector, in cylindrical coordinates. This formulation appears to have inherent advantages over the classical formulation by Sommerfeld, performed in the spatial domain, since it avoids the use of the so-called Hertz potential and its subsequent differentiation for the calculation of the received EM field. Subsequent use of the stationary phase method in the high frequency regime yields closed-form analytical solutions for the received EM field vectors, which coincide with the corresponding reflected EM field originating from the image point. In this way, we conclude that the so-called “space wave” in the literature represents the total solution of the Sommerfeld problem in the high frequency regime, in which case the surface wave can be ignored. Finally, numerical results are presented, in comparison with corresponding numerical results based on Norton’s solution of the problem.

Work domain constraints for modelling surgical performance.

Science.gov (United States)

Morineau, Thierry; Riffaud, Laurent; Morandi, Xavier; Villain, Jonathan; Jannin, Pierre

2015-10-01

Three main approaches can be identified for modelling surgical performance: a competency-based approach, a task-based approach, both largely explored in the literature, and a less known work domain-based approach. The work domain-based approach first describes the work domain properties that constrain the agent's actions and shape the performance. This paper presents a work domain-based approach for modelling performance during cervical spine surgery, based on the idea that anatomical structures delineate the surgical performance. This model was evaluated through an analysis of junior and senior surgeons' actions. Twenty-four cervical spine surgeries performed by two junior and two senior surgeons were recorded in real time by an expert surgeon. According to a work domain-based model describing an optimal progression through anatomical structures, the degree of adjustment of each surgical procedure to a statistical polynomial function was assessed. Each surgical procedure showed a significant suitability with the model and regression coefficient values around 0.9. However, the surgeries performed by senior surgeons fitted this model significantly better than those performed by junior surgeons. Analysis of the relative frequencies of actions on anatomical structures showed that some specific anatomical structures discriminate senior from junior performances. The work domain-based modelling approach can provide an overall statistical indicator of surgical performance, but in particular, it can highlight specific points of interest among anatomical structures that the surgeons dwelled on according to their level of expertise.

Domains and domain loss

DEFF Research Database (Denmark)

Haberland, Hartmut

2005-01-01

politicians and in the media, especially in the discussion whether some languages undergo ‘domain loss’ vis-à-vis powerful international languages like English. An objection that has been raised here is that domains, as originally conceived, are parameters of language choice and not properties of languages...

Improving the performance of DomainDiscovery of protein domain boundary assignment using inter-domain linker index

Directory of Open Access Journals (Sweden)

Zomaya Albert Y

2006-12-01

Full Text Available Abstract Background Knowledge of protein domain boundaries is critical for the characterisation and understanding of protein function. The ability to identify domains without the knowledge of the structure – by using sequence information only – is an essential step in many types of protein analyses. In this present study, we demonstrate that the performance of DomainDiscovery is improved significantly by including the inter-domain linker index value for domain identification from sequence-based information. Improved DomainDiscovery uses a Support Vector Machine (SVM approach and a unique training dataset built on the principle of consensus among experts in defining domains in protein structure. The SVM was trained using a PSSM (Position Specific Scoring Matrix, secondary structure, solvent accessibility information and inter-domain linker index to detect possible domain boundaries for a target sequence. Results Improved DomainDiscovery is compared with other methods by benchmarking against a structurally non-redundant dataset and also CASP5 targets. Improved DomainDiscovery achieves 70% accuracy for domain boundary identification in multi-domains proteins. Conclusion Improved DomainDiscovery compares favourably to the performance of other methods and excels in the identification of domain boundaries for multi-domain proteins as a result of introducing support vector machine with benchmark_2 dataset.

Electronic warfare receivers and receiving systems

CERN Document Server

Poisel, Richard A

2014-01-01

Receivers systems are considered the core of electronic warfare (EW) intercept systems. Without them, the fundamental purpose of such systems is null and void. This book considers the major elements that make up receiver systems and the receivers that go in them.This resource provides system design engineers with techniques for design and development of EW receivers for modern modulations (spread spectrum) in addition to receivers for older, common modulation formats. Each major module in these receivers is considered in detail. Design information is included as well as performance tradeoffs o

D Semantic Labeling of ALS Data Based on Domain Adaption by Transferring and Fusing Random Forest Models

Science.gov (United States)

Wu, J.; Yao, W.; Zhang, J.; Li, Y.

2018-04-01

Labeling 3D point cloud data with traditional supervised learning methods requires considerable labelled samples, the collection of which is cost and time expensive. This work focuses on adopting domain adaption concept to transfer existing trained random forest classifiers (based on source domain) to new data scenes (target domain), which aims at reducing the dependence of accurate 3D semantic labeling in point clouds on training samples from the new data scene. Firstly, two random forest classifiers were firstly trained with existing samples previously collected for other data. They were different from each other by using two different decision tree construction algorithms: C4.5 with information gain ratio and CART with Gini index. Secondly, four random forest classifiers adapted to the target domain are derived through transferring each tree in the source random forest models with two types of operations: structure expansion and reduction-SER and structure transfer-STRUT. Finally, points in target domain are labelled by fusing the four newly derived random forest classifiers using weights of evidence based fusion model. To validate our method, experimental analysis was conducted using 3 datasets: one is used as the source domain data (Vaihingen data for 3D Semantic Labelling); another two are used as the target domain data from two cities in China (Jinmen city and Dunhuang city). Overall accuracies of 85.5 % and 83.3 % for 3D labelling were achieved for Jinmen city and Dunhuang city data respectively, with only 1/3 newly labelled samples compared to the cases without domain adaption.

Model for Semantically Rich Point Cloud Data

Science.gov (United States)

Poux, F.; Neuville, R.; Hallot, P.; Billen, R.

2017-10-01

This paper proposes an interoperable model for managing high dimensional point clouds while integrating semantics. Point clouds from sensors are a direct source of information physically describing a 3D state of the recorded environment. As such, they are an exhaustive representation of the real world at every scale: 3D reality-based spatial data. Their generation is increasingly fast but processing routines and data models lack of knowledge to reason from information extraction rather than interpretation. The enhanced smart point cloud developed model allows to bring intelligence to point clouds via 3 connected meta-models while linking available knowledge and classification procedures that permits semantic injection. Interoperability drives the model adaptation to potentially many applications through specialized domain ontologies. A first prototype is implemented in Python and PostgreSQL database and allows to combine semantic and spatial concepts for basic hybrid queries on different point clouds.

MODEL FOR SEMANTICALLY RICH POINT CLOUD DATA

Directory of Open Access Journals (Sweden)

F. Poux

2017-10-01

Full Text Available This paper proposes an interoperable model for managing high dimensional point clouds while integrating semantics. Point clouds from sensors are a direct source of information physically describing a 3D state of the recorded environment. As such, they are an exhaustive representation of the real world at every scale: 3D reality-based spatial data. Their generation is increasingly fast but processing routines and data models lack of knowledge to reason from information extraction rather than interpretation. The enhanced smart point cloud developed model allows to bring intelligence to point clouds via 3 connected meta-models while linking available knowledge and classification procedures that permits semantic injection. Interoperability drives the model adaptation to potentially many applications through specialized domain ontologies. A first prototype is implemented in Python and PostgreSQL database and allows to combine semantic and spatial concepts for basic hybrid queries on different point clouds.

Nanomagnetic domains of chromium deposited on vertically-aligned carbon nanotubes

Energy Technology Data Exchange (ETDEWEB)

Wright, Andrew C., E-mail: a.wright@glyndwr.ac.uk [Advanced Materials Research Laboratory, Materials Science Research Center, Glyndwr University, Wrexham LL11 2AW (United Kingdom); Faulkner, Michael K., E-mail: m.faulkner@manchester.ac.uk [Manchester Materials Science Centre, University of Manchester, Grosvenor Street, Manchester M13 9PL (United Kingdom); Harris, Robert C.; Goddard, Alex; Abbott, Andrew P., E-mail: apa1@le.ac.uk [Department of Chemistry, University of Leicester, Leicester LE1 7RH (United Kingdom)

2012-12-15

The drive to create ever smaller magnetic memory devices has led to the development of new nanomagnetic domains on surfaces. This paper reports the development of nano-chromium magnetic domains obtained using electrodeposition on vertically aligned carbon nanofibers arrays. Attempts to achieve this using conventional aqueous solutions were unsuccessful even after thin nickel underlayers were applied. The use of a novel electrolyte, a deep eutectic solvent, made from choline chloride: chromium (III) chloride enabled highly conformal overcoatings of chromium on individual bare carbon nanotubes to be obtained. Very high aspect ratio metal microstructures could be obtained by this novel technology. Magnetic imaging of the coated nanoarrays showed there to be clear magnetic character to the coating when the thin coatings were applied but this disappeared when the deposits were thicker and more contiguous. - Highlights: Black-Right-Pointing-Pointer Nanoscale chromium deposited from non-aqueous electrolyte shows magnetic behavior. Black-Right-Pointing-Pointer Vertically aligned carbon nanotubes conformally coated with chromium metal. Black-Right-Pointing-Pointer Ionic liquid electrolyte superior to chromic acid for plating high aspect ratio structures.

Volume of the domain visited by N spherical Brownian particles

International Nuclear Information System (INIS)

Berezhkovskii, A.M.

1994-01-01

The average value and variance of the volume of the domain visited in time t by N spherical Brownian particles starting initially at the same point are presented as quadratures of the solutions of simple diffusion problems of the survival of a point Brownian particle in the presence of one and two spherical traps. As an illustration, explicit time dependences are obtained for the average volume in one and three dimensions

A Frequency Domain Design Method For Sampled-Data Compensators

DEFF Research Database (Denmark)

Niemann, Hans Henrik; Jannerup, Ole Erik

1990-01-01

A new approach to the design of a sampled-data compensator in the frequency domain is investigated. The starting point is a continuous-time compensator for the continuous-time system which satisfy specific design criteria. The new design method will graphically show how the discrete...

Transformation of a wave energy spectrum from encounter to absolute domain when observing from an advancing ship

DEFF Research Database (Denmark)

Nielsen, Ulrik Dam

2017-01-01

directly in the encounter domain. The encounter domain is that observed from a ship when it advances in a seaway, whereas the absolute domain is that corresponding to making observations from a fixed point in the inertial frame. Spectrum transformation can be uniquely carried out if the ship sails ”against...

Training Peer-Feedback Skills on Geometric Construction Tasks: Role of Domain Knowledge and Peer-Feedback Levels

Science.gov (United States)

Alqassab, Maryam; Strijbos, Jan-Willem; Ufer, Stefan

2018-01-01

Peer feedback is widely used to train assessment skills and to support collaborative learning of various learning tasks, but research on peer feedback in the domain of mathematics is limited. Although domain knowledge seems to be a prerequisite for peer-feedback provision, it only recently received attention in the peer-feedback literature. In…

Wideband Impulse Modulation and Receiver Algorithms for Multiuser Power Line Communications

Directory of Open Access Journals (Sweden)

Andrea M. Tonello

2007-01-01

Full Text Available We consider a bit-interleaved coded wideband impulse-modulated system for power line communications. Impulse modulation is combined with direct-sequence code-division multiple access (DS-CDMA to obtain a form of orthogonal modulation and to multiplex the users. We focus on the receiver signal processing algorithms and derive a maximum likelihood frequency-domain detector that takes into account the presence of impulse noise as well as the intercode interference (ICI and the multiple-access interference (MAI that are generated by the frequency-selective power line channel. To reduce complexity, we propose several simplified frequency-domain receiver algorithms with different complexity and performance. We address the problem of the practical estimation of the channel frequency response as well as the estimation of the correlation of the ICI-MAI-plus-noise that is needed in the detection metric. To improve the estimators performance, a simple hard feedback from the channel decoder is also used. Simulation results show that the scheme provides robust performance as a result of spreading the symbol energy both in frequency (through the wideband pulse and in time (through the spreading code and the bit-interleaved convolutional code.

3D SEMANTIC LABELING OF ALS DATA BASED ON DOMAIN ADAPTION BY TRANSFERRING AND FUSING RANDOM FOREST MODELS

Directory of Open Access Journals (Sweden)

J. Wu

2018-04-01

Full Text Available Labeling 3D point cloud data with traditional supervised learning methods requires considerable labelled samples, the collection of which is cost and time expensive. This work focuses on adopting domain adaption concept to transfer existing trained random forest classifiers (based on source domain to new data scenes (target domain, which aims at reducing the dependence of accurate 3D semantic labeling in point clouds on training samples from the new data scene. Firstly, two random forest classifiers were firstly trained with existing samples previously collected for other data. They were different from each other by using two different decision tree construction algorithms: C4.5 with information gain ratio and CART with Gini index. Secondly, four random forest classifiers adapted to the target domain are derived through transferring each tree in the source random forest models with two types of operations: structure expansion and reduction-SER and structure transfer-STRUT. Finally, points in target domain are labelled by fusing the four newly derived random forest classifiers using weights of evidence based fusion model. To validate our method, experimental analysis was conducted using 3 datasets: one is used as the source domain data (Vaihingen data for 3D Semantic Labelling; another two are used as the target domain data from two cities in China (Jinmen city and Dunhuang city. Overall accuracies of 85.5 % and 83.3 % for 3D labelling were achieved for Jinmen city and Dunhuang city data respectively, with only 1/3 newly labelled samples compared to the cases without domain adaption.

Longitudinal analysis of domain-level breast cancer literacy among African-American women.

Science.gov (United States)

Mabiso, Athur; Williams, Karen Patricia; Todem, David; Templin, Thomas N

2010-02-01

Functional breast cancer literacy was assessed among African-American women and measured at the domain level over time. We used the Kin Keeper(SM) Cancer Prevention Intervention to educate 161 African-American women on three domains of breast cancer literacy: (i) cancer awareness, (ii) knowledge of breast cancer screening modalities and (iii) cancer prevention and control. A breast cancer literacy assessment was administered pre- and post-educational intervention at two time points followed by another assessment 12 months after the second intervention. Generalized estimating equations were specified to predict the probability of correctly answering questions in each domain over time. Domain-level literacy differentials exist; at baseline, women had higher test scores in the breast cancer prevention and control domain than the cancer awareness domain (odds ratio = 1.67, 95% confidence interval 1.19-2.34). After Kin Keeper(SM) Cancer Prevention Intervention, African-American women consistently improved their breast cancer literacy in all domains over the five time stages (P < 0.001) though at different rates for each domain. Differences in domain-level breast cancer literacy highlight the importance of assessing literacy at the domain level. Interventions to improve African-American women's breast cancer literacy should focus on knowledge of breast cancer screening modalities and cancer awareness domains.

Superbinder SH2 domains act as antagonists of cell signaling.

Science.gov (United States)

Kaneko, Tomonori; Huang, Haiming; Cao, Xuan; Li, Xing; Li, Chengjun; Voss, Courtney; Sidhu, Sachdev S; Li, Shawn S C

2012-09-25

Protein-ligand interactions mediated by modular domains, which often play important roles in regulating cellular functions, are generally of moderate affinities. We examined the Src homology 2 (SH2) domain, a modular domain that recognizes phosphorylated tyrosine (pTyr) residues, to investigate how the binding affinity of a modular domain for its ligand influences the structure and cellular function of the protein. We used the phage display method to perform directed evolution of the pTyr-binding residues in the SH2 domain of the tyrosine kinase Fyn and identified three amino acid substitutions that critically affected binding. We generated three SH2 domain triple-point mutants that were "superbinders" with much higher affinities for pTyr-containing peptides than the natural domain. Crystallographic analysis of one of these superbinders revealed that the superbinder SH2 domain recognized the pTyr moiety in a bipartite binding mode: A hydrophobic surface encompassed the phenyl ring, and a positively charged site engaged the phosphate. When expressed in mammalian cells, the superbinder SH2 domains blocked epidermal growth factor receptor signaling and inhibited anchorage-independent cell proliferation, suggesting that pTyr superbinders might be explored for therapeutic applications and useful as biological research tools. Although the SH2 domain fold can support much higher affinity for its ligand than is observed in nature, our results suggest that natural SH2 domains are not optimized for ligand binding but for specificity and flexibility, which are likely properties important for their function in signaling and regulatory processes.

Optical antenna for a visible light communications receiver

Science.gov (United States)

Valencia-Estrada, Juan Camilo; García-Márquez, Jorge; Topsu, Suat; Chassagne, Luc

2018-01-01

Visible Light Communications (VLC) receivers adapted to be used in high transmission rates will eventually use either, high aperture lenses or non-linear optical elements capable of converting light arriving to the receiver into an electric signal. The high aperture lens case, reveals a challenge from an optical designers point-of-view. As a matter of fact, the lens must collect a wide aperture intensity flux using a limited aperture as its use is intended to portable devices. This last also limits both, lens thickness and its focal length. Here, we show a first design to be adapted to a VLC receiver that take these constraints into account. This paper describes a method to design catadioptric and monolithic lenses to be used as an optical collector of light entering from a near point light source as a spherical fan L with a wide acceptance angle α° and high efficiency. These lenses can be mass produced and therefore one can find many practical applications in VLC equipped devices. We show a first design for a near light source without magnification, and second one with a detector's magnification in a meridional section. We utilize rigorous geometric optics, vector analysis and ordinary differential equations.

On the Required Number of Antennas in a Point-to-Point Large-but-Finite MIMO System: Outage-Limited Scenario

KAUST Repository

Makki, Behrooz

2016-03-22

This paper investigates the performance of the point-To-point multiple-input-multiple-output (MIMO) systems in the presence of a large but finite numbers of antennas at the transmitters and/or receivers. Considering the cases with and without hybrid automatic repeat request (HARQ) feedback, we determine the minimum numbers of the transmit/receive antennas, which are required to satisfy different outage probability constraints. Our results are obtained for different fading conditions and the effect of the power amplifiers efficiency/feedback error probability on the performance of the MIMO-HARQ systems is analyzed. Then, we use some recent results on the achievable rates of finite block-length codes, to analyze the effect of the codewords lengths on the system performance. Moreover, we derive closed-form expressions for the asymptotic performance of the MIMO-HARQ systems when the number of antennas increases. Our analytical and numerical results show that different outage requirements can be satisfied with relatively few transmit/receive antennas. © 1972-2012 IEEE.

Distributions of chain ends and junction points in ordered block copolymers

International Nuclear Information System (INIS)

Mayes, A.M.; Johnson, R.D.; Russell, T.P.; Smith, S.D.; Satija, S.K.; Majkrzak, C.F.

1993-01-01

Chain configurations in ordered symmetric poly(styrene-b-methyl methacrylate) diblock copolymers were examined by neutron reflectively. In a thin-film geometry the copolymers organize into lamellar microdomains oriented parallel to the substrate surface. The copolymers organize into lamellar microdomains oriented parallel to the substrate surface. The copolymers were synthesized with small fractions of deuterated segments at either the chain ends or centers. This selective labeling permitted characterization of the spatial distribution of chain ends and junction points normal to the plane of the film. From the reflectivity analysis, the junction points are found to be confined to the PS/PMMA interfacial regions. The chain ends, however, are well distributed through their respective domains, exhibiting only a weak maximum in concentration at the center of the domains

On the Restriction of the Location of Stable Points for Generalized Lotka-Volterra

OpenAIRE

Livesay, Michael Richard

2017-01-01

We develop tools to determine which fixed points in a generalized Lotka-Volterra system are stable, under certain non-degeneracy conditions. We characterize which faces of the boundary of the domain of the Lotka-Volterra system could contain a stable fixed point. Under various relaxed conditions, we show that whenever a face of the boundary contains a stable point there are no other stable points in any strictly larger face of the boundary.

Point-to-point microwave power transmission experiment; Maikuroha ni yoru denryoku yuso no kiso kenkyu

Energy Technology Data Exchange (ETDEWEB)

Shimokura, N.; Kirihara, T. [Kansai Electric Power Co. Inc., Osaka (Japan)

1997-09-30

In order to demonstrate the power transmission using microwave and arrange advantages and problems in the wireless power transmission, field tests of point-to-point power transmission were conducted. Microwave frequency of 2.45 GHz was used, which is assigned as the industrial, scientific and medical frequency. The transmission system is composed of generator, director tube, primary radiator, and transmission antenna. The maximum 5 kW of microwave power can be transmitted by combining a 3 m-diameter parabolic antenna and a magnetron. The receiving system is composed of devices called as RECTENNA (rectifying antenna). A large capacity and high efficiency RECTENNA was developed, by which the maximum 2.5 W of input power per single device can be provided. As a result of the experiments, efficiency at the transmission side was over 70%, and RF-DC efficiency at the receiving side was about 51%. At the open-air test site, however, the total efficiency of only 14.8% could be obtained. 8 refs., 12 figs.

Thermodynamic study of the native and phosphorylated regulatory domain of the CFTR

Energy Technology Data Exchange (ETDEWEB)

Marasini, Carlotta, E-mail: marasini@ge.ibf.cnr.it [Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via De Marini 6, 16149 Genova (Italy); Galeno, Lauretta; Moran, Oscar [Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via De Marini 6, 16149 Genova (Italy)

2012-07-06

Highlights: Black-Right-Pointing-Pointer CFTR mutations produce cystic fibrosis. Black-Right-Pointing-Pointer Chloride transport depends on the regulatory domain phosphorylation. Black-Right-Pointing-Pointer Regulatory domain is intrinsically disordered. Black-Right-Pointing-Pointer Secondary structure and protein stability change upon phosphorylation. -- Abstract: The regulatory domain (RD) of the cystic fibrosis transmembrane conductance regulator (CFTR), the defective protein in cystic fibrosis, is the region of the channel that regulates the CFTR activity with multiple phosphorylation sites. This domain is an intrinsically disordered protein, characterized by lack of stable or unique tertiary structure. The disordered character of a protein is directly correlated with its function. The flexibility of RD may be important for its regulatory role: the continuous conformational change may be necessary for the progressive phosphorylation, and thus activation, of the channel. However, the lack of a defined and stable structure results in a considerable limitation when trying to in build a unique molecular model for the RD. Moreover, several evidences indicate significant structural differences between the native, non-phosphorylated state, and the multiple phosphorylated state of the protein. The aim of our work is to provide data to describe the conformations and the thermodynamic properties in these two functional states of RD. We have done the circular dichroism (CD) spectra in samples with a different degree of phosphorylation, from the non-phosphorylated state to a bona fide completely phosphorylated state. Analysis of CD spectra showed that the random coil and {beta}-sheets secondary structure decreased with the polypeptide phosphorylation, at expenses of an increase of {alpha}-helix. This observation lead to interpret phosphorylation as a mechanism favoring a more structured state. We also studied the thermal denaturation curves of the protein in the two

Using a space filling curve approach for the management of dynamic point clouds

NARCIS (Netherlands)

Psomadaki, S; van Oosterom, P.J.M.; Tijssen, T.P.M.; Baart, F.

2016-01-01

Point cloud usage has increased over the years. The development of low-cost sensors makes it now possible to acquire frequent point cloud measurements on a short time period (day, hour, second). Based on the requirements coming from the coastal monitoring domain, we have developed, implemented and

Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster

Energy Technology Data Exchange (ETDEWEB)

Vognsen, Tina, E-mail: tv@farma.ku.dk [Biostructural Research, Department of Drug Design and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen (Denmark); Kristensen, Ole, E-mail: ok@farma.ku.dk [Biostructural Research, Department of Drug Design and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen (Denmark)

2012-03-30

Highlights: Black-Right-Pointing-Pointer The crystal structure of the NTF2-like domain of Rasputin protein is presented. Black-Right-Pointing-Pointer Differences to known ligand binding sites of nuclear transport factor 2 are discussed. Black-Right-Pointing-Pointer A new ligand binding site for the Rasputin and G3BP proteins is proposed. -- Abstract: The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7 A resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised of a {beta}-sheet and three {alpha}-helices forming a cone-like shape. However, known binding sites for RanGDP and FxFG containing peptides show electrostatic and steric differences compared to nuclear transport factor 2. A HEPES molecule bound in the structure suggests a new, and possibly physiologically relevant, ligand binding site.

On the Equational Definition of the Least Prefixed Point

DEFF Research Database (Denmark)

Santocanale, Luigi

2001-01-01

We show how to axiomatize by equations the least prefixed point of an order preserving function and discuss the domain of application of the proposed method. Thus, we generalize the well known equational axiomatization of Propositional Dynamic Logic to a complete equational axiomatization of the ...

Ketidakseimbangan Instrumen Penilaian Pada Domain Pembelajaran

Directory of Open Access Journals (Sweden)

Yuberti Yuberti

2015-04-01

Full Text Available Generally, the result of teaching and learning process pointed to three basic aspects, they are; cognitive, affective, and psycomotoric that must be achieved by the students. These three aspects can not be divided because they are a unity. Teaching and learning hold one important aspect in education, that is to develop and empower cognitive, affective, and psycomotoric to create students effectively. The three domains should be underwritten in teaching learning process they cover lesson planning, lesson implementation, the result of evaluation and supervision of teaching and learning process. Based on the concept result teaching and learning throughly, the teacher are obligated to make instruments for three domains in teaching and learning process and it’s application. Various kind of evaluation are made to get the responsibly result of students’ teaching and learning can describe students ability comprehensively. Secara umum, hasil pembelajaran mengarah pada tiga hal pokok yang harus mampu dicapai peserta didik, yaitu Afektif, Kognitif dan Psikomotorik. Ketiga hal ini tidak boleh dipisahkan karena merupakan satu kesatuan. Pembelajaran sebagai salah satu aspek penting dalam pendidikan memegang peranan mengembangkan dan memberdayakan domain kognitif, afektif, dan psikomotor bagi peserta didik secara seimbang. Keseimbangan pengembangan dan pemberdayaan ketiga domain tersebut harus tertuang dengan jelas dalam proses pembelajaran, meliputi perencanaan pembelajaran, pelaksanaan pembelajaran, penilaian hasil pembelajaran, dan pengawasan proses pembelajaran. Berdasarkan konsep hasil belajar yang bersifat menyeluruh, sudah menjadi keharusan bahwa guru harus membuat instrumen pada ketiga ranah dalam pembelajaran tersebut dan melakukan penerapan penilaiannya. Berbagai bentuk penilaian dibuat untuk memperoleh hasil belajar peserta didik yang dapat dipertanggungjawabkan serta benar-benar dapat menggambarkan kemampuan peserta didik secara komprehensif

Topography and instability of monolayers near domain boundaries

International Nuclear Information System (INIS)

Diamant, H.; Witten, T. A.; Ege, C.; Gopal, A.; Lee, K. Y. C.

2001-01-01

We theoretically study the topography of a biphasic surfactant monolayer in the vicinity of domain boundaries. The differing elastic properties of the two phases generally lead to a nonflat topography of 'mesas,' where domains of one phase are elevated with respect to the other phase. The mesas are steep but low, having heights of up to 10 nm. As the monolayer is laterally compressed, the mesas develop overhangs and eventually become unstable at a surface tension of about K(δc 0 ) 2 (δc 0 being the difference in spontaneous curvature and K a bending modulus). In addition, the boundary is found to undergo a topography-induced rippling instability upon compression, if its line tension is smaller than about Kδc 0 . The effect of diffuse boundaries on these features and the topographic behavior near a critical point are also examined. We discuss the relevance of our findings to several experimental observations related to surfactant monolayers: (i) small topographic features recently found near domain boundaries; (ii) folding behavior observed in mixed phospholipid monolayers and model lung surfactants; (iii) roughening of domain boundaries seen under lateral compression; (iv) the absence of biphasic structures in tensionless surfactant films

Receiver gain function: the actual NMR receiver gain

OpenAIRE

Mo, Huaping; Harwood, John S.; Raftery, Daniel

2010-01-01

The observed NMR signal size depends on the receiver gain parameter. We propose a receiver gain function to characterize how much the raw FID is amplified by the receiver as a function of the receiver gain setting. Although the receiver is linear for a fixed gain setting, the actual gain of the receiver may differ from what the gain setting suggests. Nevertheless, for a given receiver, we demonstrate that the receiver gain function can be calibrated. Such a calibration enables accurate compar...

Angle-domain inverse scattering migration/inversion in isotropic media

Science.gov (United States)

Li, Wuqun; Mao, Weijian; Li, Xuelei; Ouyang, Wei; Liang, Quan

2018-07-01

The classical seismic asymptotic inversion can be transformed into a problem of inversion of generalized Radon transform (GRT). In such methods, the combined parameters are linearly attached to the scattered wave-field by Born approximation and recovered by applying an inverse GRT operator to the scattered wave-field data. Typical GRT-style true-amplitude inversion procedure contains an amplitude compensation process after the weighted migration via dividing an illumination associated matrix whose elements are integrals of scattering angles. It is intuitional to some extent that performs the generalized linear inversion and the inversion of GRT together by this process for direct inversion. However, it is imprecise to carry out such operation when the illumination at the image point is limited, which easily leads to the inaccuracy and instability of the matrix. This paper formulates the GRT true-amplitude inversion framework in an angle-domain version, which naturally degrades the external integral term related to the illumination in the conventional case. We solve the linearized integral equation for combined parameters of different fixed scattering angle values. With this step, we obtain high-quality angle-domain common-image gathers (CIGs) in the migration loop which provide correct amplitude-versus-angle (AVA) behavior and reasonable illumination range for subsurface image points. Then we deal with the over-determined problem to solve each parameter in the combination by a standard optimization operation. The angle-domain GRT inversion method keeps away from calculating the inaccurate and unstable illumination matrix. Compared with the conventional method, the angle-domain method can obtain more accurate amplitude information and wider amplitude-preserved range. Several model tests demonstrate the effectiveness and practicability.

The BRCT domain is a phospho-protein binding domain.

Science.gov (United States)

Yu, Xiaochun; Chini, Claudia Christiano Silva; He, Miao; Mer, Georges; Chen, Junjie

2003-10-24

The carboxyl-terminal domain (BRCT) of the Breast Cancer Gene 1 (BRCA1) protein is an evolutionarily conserved module that exists in a large number of proteins from prokaryotes to eukaryotes. Although most BRCT domain-containing proteins participate in DNA-damage checkpoint or DNA-repair pathways, or both, the function of the BRCT domain is not fully understood. We show that the BRCA1 BRCT domain directly interacts with phosphorylated BRCA1-Associated Carboxyl-terminal Helicase (BACH1). This specific interaction between BRCA1 and phosphorylated BACH1 is cell cycle regulated and is required for DNA damage-induced checkpoint control during the transition from G2 to M phase of the cell cycle. Further, we show that two other BRCT domains interact with their respective physiological partners in a phosphorylation-dependent manner. Thirteen additional BRCT domains also preferentially bind phospho-peptides rather than nonphosphorylated control peptides. These data imply that the BRCT domain is a phospho-protein binding domain involved in cell cycle control.

Charge-Domain Signal Processing of Direct RF Sampling Mixer with Discrete-Time Filters in Bluetooth and GSM Receivers

Directory of Open Access Journals (Sweden)

2006-01-01

Full Text Available RF circuits for multi-GHz frequencies have recently migrated to low-cost digital deep-submicron CMOS processes. Unfortunately, this process environment, which is optimized only for digital logic and SRAM memory, is extremely unfriendly for conventional analog and RF designs. We present fundamental techniques recently developed that transform the RF and analog circuit design complexity to digitally intensive domain for a wireless RF transceiver, so that it enjoys benefits of digital and switched-capacitor approaches. Direct RF sampling techniques allow great flexibility in reconfigurable radio design. Digital signal processing concepts are used to help relieve analog design complexity, allowing one to reduce cost and power consumption in a reconfigurable design environment. The ideas presented have been used in Texas Instruments to develop two generations of commercial digital RF processors: a single-chip Bluetooth radio and a single-chip GSM radio. We further present details of the RF receiver front end for a GSM radio realized in a 90-nm digital CMOS technology. The circuit consisting of low-noise amplifier, transconductance amplifier, and switching mixer offers 32.5 dB dynamic range with digitally configurable voltage gain of 40 dB down to 7.5 dB. A series of decimation and discrete-time filtering follows the mixer and performs a highly linear second-order lowpass filtering to reject close-in interferers. The front-end gains can be configured with an automatic gain control to select an optimal setting to form a trade-off between noise figure and linearity and to compensate the process and temperature variations. Even under the digital switching activity, noise figure at the 40 dB maximum gain is 1.8 dB and +50 dBm IIP2 at the 34 dB gain. The variation of the input matching versus multiple gains is less than 1 dB. The circuit in total occupies 3.1 mm 2 . The LNA, TA, and mixer consume less than 15.3 mA at a supply voltage of 1.4 V.

Charge-Domain Signal Processing of Direct RF Sampling Mixer with Discrete-Time Filters in Bluetooth and GSM Receivers

Directory of Open Access Journals (Sweden)

Ho Yo-Chuol

2006-01-01

Full Text Available RF circuits for multi-GHz frequencies have recently migrated to low-cost digital deep-submicron CMOS processes. Unfortunately, this process environment, which is optimized only for digital logic and SRAM memory, is extremely unfriendly for conventional analog and RF designs. We present fundamental techniques recently developed that transform the RF and analog circuit design complexity to digitally intensive domain for a wireless RF transceiver, so that it enjoys benefits of digital and switched-capacitor approaches. Direct RF sampling techniques allow great flexibility in reconfigurable radio design. Digital signal processing concepts are used to help relieve analog design complexity, allowing one to reduce cost and power consumption in a reconfigurable design environment. The ideas presented have been used in Texas Instruments to develop two generations of commercial digital RF processors: a single-chip Bluetooth radio and a single-chip GSM radio. We further present details of the RF receiver front end for a GSM radio realized in a 90-nm digital CMOS technology. The circuit consisting of low-noise amplifier, transconductance amplifier, and switching mixer offers dB dynamic range with digitally configurable voltage gain of 40 dB down to dB. A series of decimation and discrete-time filtering follows the mixer and performs a highly linear second-order lowpass filtering to reject close-in interferers. The front-end gains can be configured with an automatic gain control to select an optimal setting to form a trade-off between noise figure and linearity and to compensate the process and temperature variations. Even under the digital switching activity, noise figure at the 40 dB maximum gain is 1.8 dB and dBm IIP2 at the 34 dB gain. The variation of the input matching versus multiple gains is less than 1 dB. The circuit in total occupies 3.1 . The LNA, TA, and mixer consume less than mA at a supply voltage of 1.4 V.

Algebraic and radical potential fields. Stability domains in coordinate and parametric space

Science.gov (United States)

Uteshev, Alexei Yu.

2018-05-01

A dynamical system d X/d t = F(X; A) is treated where F(X; A) is a polynomial (or some general type of radical contained) function in the vectors of state variables X ∈ ℝn and parameters A ∈ ℝm. We are looking for stability domains in both spaces, i.e. (a) domain ℙ ⊂ ℝm such that for any parameter vector specialization A ∈ ℙ, there exists a stable equilibrium for the dynamical system, and (b) domain 𝕊 ⊂ ℝn such that any point X* ∈ 𝕊 could be made a stable equilibrium by a suitable specialization of the parameter vector A.

Off the Trodden Path: Thinking Through the Military Exploration of the Information Domain

National Research Council Canada - National Science Library

O'Connell, Ed

1997-01-01

Trends in today's security environment point to a changed information domain on the horizon--a cyberspace of increased density, interconnectivity and collaboration, where links and nodes have disappeared...

Characterizing fixed points

Directory of Open Access Journals (Sweden)

Sanjo Zlobec

2017-04-01

Full Text Available A set of sufficient conditions which guarantee the existence of a point x⋆ such that f(x⋆ = x⋆ is called a "fixed point theorem". Many such theorems are named after well-known mathematicians and economists. Fixed point theorems are among most useful ones in applied mathematics, especially in economics and game theory. Particularly important theorem in these areas is Kakutani's fixed point theorem which ensures existence of fixed point for point-to-set mappings, e.g., [2, 3, 4]. John Nash developed and applied Kakutani's ideas to prove the existence of (what became known as "Nash equilibrium" for finite games with mixed strategies for any number of players. This work earned him a Nobel Prize in Economics that he shared with two mathematicians. Nash's life was dramatized in the movie "Beautiful Mind" in 2001. In this paper, we approach the system f(x = x differently. Instead of studying existence of its solutions our objective is to determine conditions which are both necessary and sufficient that an arbitrary point x⋆ is a fixed point, i.e., that it satisfies f(x⋆ = x⋆. The existence of solutions for continuous function f of the single variable is easy to establish using the Intermediate Value Theorem of Calculus. However, characterizing fixed points x⋆, i.e., providing answers to the question of finding both necessary and sufficient conditions for an arbitrary given x⋆ to satisfy f(x⋆ = x⋆, is not simple even for functions of the single variable. It is possible that constructive answers do not exist. Our objective is to find them. Our work may require some less familiar tools. One of these might be the "quadratic envelope characterization of zero-derivative point" recalled in the next section. The results are taken from the author's current research project "Studying the Essence of Fixed Points". They are believed to be original. The author has received several feedbacks on the preliminary report and on parts of the project

Calculations of received dose for different points in the enrichment uranium oxide warehouse at 4%

International Nuclear Information System (INIS)

Alonso V, G.

1990-06-01

In order to verifying that the received dose so much inside as outside of the warehouse of enriched uranium dioxide to 4% it doesn't represent risk to the personnel, the modelling of this and the corresponding calculations for the extreme case of dose at contact are made. (Author)

Toward 5G software defined radio receiver front-ends

CERN Document Server

Spiridon, Silvian

2016-01-01

This book introduces a new intuitive design methodology for the optimal design path for next-generation software defined radio front-ends (SDRXs). The methodology described empowers designers to "attack" the multi-standard environment in a parallel way rather than serially, providing a critical tool for any design methodology targeting 5G circuits and systems. Throughout the book the SDRX design follows the key wireless standards of the moment (i.e., GSM, WCDMA, LTE, Bluetooth, WLAN), since a receiver compatible with these standards is the most likely candidate for the first design iteration in a 5G deployment. The author explains the fundamental choice the designer has to make regarding the optimal channel selection: how much of the blockers/interferers will be filtered in the analog domain and how much will remain to be filtered in the digital domain. The system-level analysis the author describes entails the direct sampling architecture is treated as a particular case of mixer-based direct conversion archi...

Solar thermal power systems point-focusing thermal and electric applications projects. Volume 1: Executive summary

Science.gov (United States)

Marriott, A.

1980-01-01

The activities of the Point-Focusing Thermal and Electric Applications (PETEA) project for the fiscal year 1979 are summarized. The main thrust of the PFTEA Project, the small community solar thermal power experiment, was completed. Concept definition studies included a small central receiver approach, a point-focusing distributed receiver system with central power generation, and a point-focusing distributed receiver concept with distributed power generation. The first experiment in the Isolated Application Series was initiated. Planning for the third engineering experiment series, which addresses the industrial market sector, was also initiated. In addition to the experiment-related activities, several contracts to industry were let and studies were conducted to explore the market potential for point-focusing distributed receiver (PFDR) systems. System analysis studies were completed that looked at PFDR technology relative to other small power system technology candidates for the utility market sector.

SMART POINT CLOUD: DEFINITION AND REMAINING CHALLENGES

Directory of Open Access Journals (Sweden)

F. Poux

2016-10-01

Full Text Available Dealing with coloured point cloud acquired from terrestrial laser scanner, this paper identifies remaining challenges for a new data structure: the smart point cloud. This concept arises with the statement that massive and discretized spatial information from active remote sensing technology is often underused due to data mining limitations. The generalisation of point cloud data associated with the heterogeneity and temporality of such datasets is the main issue regarding structure, segmentation, classification, and interaction for an immediate understanding. We propose to use both point cloud properties and human knowledge through machine learning to rapidly extract pertinent information, using user-centered information (smart data rather than raw data. A review of feature detection, machine learning frameworks and database systems indexed both for mining queries and data visualisation is studied. Based on existing approaches, we propose a new 3-block flexible framework around device expertise, analytic expertise and domain base reflexion. This contribution serves as the first step for the realisation of a comprehensive smart point cloud data structure.

Comparison of Dose When Prescribed to Point A and Point H for Brachytherapy in Cervical Cancer

Energy Technology Data Exchange (ETDEWEB)

Gang, Ji Hyeong; Gim, Il Hwan; Hwang, Seon Boong; Kim, Woong; Im, Hyeong Seo; Gang, Jin Mook; Gim, Gi Hwan; Lee, Ah Ram [Dept. of Radiation Oncology, Korea Institute of Radiological and Medical Sciences, Seou (Korea, Republic of)

2012-09-15

The purpose of this study is to compare plans prescribed to point A with these prescribed to point H recommended by ABS (American Brachytherapy Society) in high dose rate intracavitary brachytherapy for cervical carcinoma. This study selected 103 patients who received HDR (High Dose Rate) brachytherapy using tandem and ovoids from March 2010 to January 2012. Point A, bladder point, and rectal point conform with Manchester System. Point H conforms with ABS recommendation. Also Sigmoid colon point, and vagina point were established arbitrarily. We examined distance between point A and point H. The percent dose at point A was calculated when 100% dose was prescribed to point H. Additionally, the percent dose at each reference points when dose is prescribed to point H and point A were calculated. The relative dose at point A was lower when point H was located inferior to point A. The relative doses at bladder, rectal, sigmoid colon, and vagina points were higher when point H was located superior to point A, and lower when point H was located inferior to point A. This study found out that as point H got located much superior to point A, the absorbed dose of surrounding normal organs became higher, and as point H got located much inferior to point A, the absorbed dose of surrounding normal organs became lower. This differences dose not seem to affect the treatment. However, we suggest this new point is worth being considered for the treatment of HDR if dose distribution and absorbed dose at normal organs have large differences between prescribed to point A and H.

Expanding the landscape of chromatin modification (CM-related functional domains and genes in human.

Directory of Open Access Journals (Sweden)

Shuye Pu

2010-11-01

Full Text Available Chromatin modification (CM plays a key role in regulating transcription, DNA replication, repair and recombination. However, our knowledge of these processes in humans remains very limited. Here we use computational approaches to study proteins and functional domains involved in CM in humans. We analyze the abundance and the pair-wise domain-domain co-occurrences of 25 well-documented CM domains in 5 model organisms: yeast, worm, fly, mouse and human. Results show that domains involved in histone methylation, DNA methylation, and histone variants are remarkably expanded in metazoan, reflecting the increased demand for cell type-specific gene regulation. We find that CM domains tend to co-occur with a limited number of partner domains and are hence not promiscuous. This property is exploited to identify 47 potentially novel CM domains, including 24 DNA-binding domains, whose role in CM has received little attention so far. Lastly, we use a consensus Machine Learning approach to predict 379 novel CM genes (coding for 329 proteins in humans based on domain compositions. Several of these predictions are supported by very recent experimental studies and others are slated for experimental verification. Identification of novel CM genes and domains in humans will aid our understanding of fundamental epigenetic processes that are important for stem cell differentiation and cancer biology. Information on all the candidate CM domains and genes reported here is publicly available.

Multifunction waveform generator for EM receiver testing

Science.gov (United States)

Chen, Kai; Jin, Sheng; Deng, Ming

2018-01-01

In many electromagnetic (EM) methods - such as magnetotelluric, spectral-induced polarization (SIP), time-domain-induced polarization (TDIP), and controlled-source audio magnetotelluric (CSAMT) methods - it is important to evaluate and test the EM receivers during their development stage. To assess the performance of the developed EM receivers, controlled synthetic data that simulate the observed signals in different modes are required. In CSAMT and SIP mode testing, the waveform generator should use the GPS time as the reference for repeating schedule. Based on our testing, the frequency range, frequency precision, and time synchronization of the currently available function waveform generators on the market are deficient. This paper presents a multifunction waveform generator with three waveforms: (1) a wideband, low-noise electromagnetic field signal to be used for magnetotelluric, audio-magnetotelluric, and long-period magnetotelluric studies; (2) a repeating frequency sweep square waveform for CSAMT and SIP studies; and (3) a positive-zero-negative-zero signal that contains primary and secondary fields for TDIP studies. In this paper, we provide the principles of the above three waveforms along with a hardware design for the generator. Furthermore, testing of the EM receiver was conducted with the waveform generator, and the results of the experiment were compared with those calculated from the simulation and theory in the frequency band of interest.

Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain

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Spaan Willy JM

2009-05-01

Full Text Available Abstract Background Hepatitis C virus (HCV induces membrane rearrangements during replication. All HCV proteins are associated to membranes, pointing out the importance of membranes for HCV. Non structural protein 4B (NS4B has been reported to induce cellular membrane alterations like the membranous web. Four transmembrane segments in the middle of the protein anchor NS4B to membranes. An amphipatic helix at the amino-terminus attaches to membranes as well. The carboxy-terminal domain (CTD of NS4B is highly conserved in Hepaciviruses, though its function remains unknown. Results A cytosolic localization is predicted for the NS4B-CTD. However, using membrane floatation assays and immunofluorescence, we now show targeting of the NS4B-CTD to membranes. Furthermore, a profile-profile search, with an HCV NS4B-CTD multiple sequence alignment, indicates sequence similarity to the membrane binding domain of prokaryotic D-lactate dehydrogenase (d-LDH. The crystal structure of E. coli d-LDH suggests that the region similar to NS4B-CTD is located in the membrane binding domain (MBD of d-LDH, implying analogy in membrane association. Targeting of d-LDH to membranes occurs via electrostatic interactions of positive residues on the outside of the protein with negative head groups of lipids. To verify that anchorage of d-LDH MBD and NS4B-CTD is analogous, NS4B-CTD mutants were designed to disrupt these electrostatic interactions. Membrane association was confirmed by swopping the membrane contacting helix of d-LDH with the corresponding domain of the 4B-CTD. Furthermore, the functionality of these residues was tested in the HCV replicon system. Conclusion Together these data show that NS4B-CTD is associated to membranes, similar to the prokaryotic d-LDH MBD, and is important for replication.

Domain analysis

DEFF Research Database (Denmark)

Hjørland, Birger

2017-01-01

The domain-analytic approach to knowledge organization (KO) (and to the broader field of library and information science, LIS) is outlined. The article reviews the discussions and proposals on the definition of domains, and provides an example of a domain-analytic study in the field of art studies....... Varieties of domain analysis as well as criticism and controversies are presented and discussed....

Energy landscape scheme for an intuitive understanding of complex domain dynamics in ferroelectric thin films

Science.gov (United States)

Heon Kim, Tae; Yoon, Jong-Gul; Hyub Baek, Seung; Park, Woong-Kyu; Mo Yang, Sang; Yup Jang, Seung; Min, Taeyuun; Chung, Jin-Seok; Eom, Chang-Beom; Won Noh, Tae

2015-07-01

Fundamental understanding of domain dynamics in ferroic materials has been a longstanding issue because of its relevance to many systems and to the design of nanoscale domain-wall devices. Despite many theoretical and experimental studies, a full understanding of domain dynamics still remains incomplete, partly due to complex interactions between domain-walls and disorder. We report domain-shape-preserving deterministic domain-wall motion, which directly confirms microscopic return point memory, by observing domain-wall breathing motion in ferroelectric BiFeO3 thin film using stroboscopic piezoresponse force microscopy. Spatial energy landscape that provides new insights into domain dynamics is also mapped based on the breathing motion of domain walls. The evolution of complex domain structure can be understood by the process of occupying the lowest available energy states of polarization in the energy landscape which is determined by defect-induced internal fields. Our result highlights a pathway for the novel design of ferroelectric domain-wall devices through the engineering of energy landscape using defect-induced internal fields such as flexoelectric fields.

Energy landscape scheme for an intuitive understanding of complex domain dynamics in ferroelectric thin films.

Science.gov (United States)

Kim, Tae Heon; Yoon, Jong-Gul; Baek, Seung Hyub; Park, Woong-kyu; Yang, Sang Mo; Yup Jang, Seung; Min, Taeyuun; Chung, Jin-Seok; Eom, Chang-Beom; Noh, Tae Won

2015-07-01

Fundamental understanding of domain dynamics in ferroic materials has been a longstanding issue because of its relevance to many systems and to the design of nanoscale domain-wall devices. Despite many theoretical and experimental studies, a full understanding of domain dynamics still remains incomplete, partly due to complex interactions between domain-walls and disorder. We report domain-shape-preserving deterministic domain-wall motion, which directly confirms microscopic return point memory, by observing domain-wall breathing motion in ferroelectric BiFeO3 thin film using stroboscopic piezoresponse force microscopy. Spatial energy landscape that provides new insights into domain dynamics is also mapped based on the breathing motion of domain walls. The evolution of complex domain structure can be understood by the process of occupying the lowest available energy states of polarization in the energy landscape which is determined by defect-induced internal fields. Our result highlights a pathway for the novel design of ferroelectric domain-wall devices through the engineering of energy landscape using defect-induced internal fields such as flexoelectric fields.

Inferring domain-domain interactions from protein-protein interactions with formal concept analysis.

Directory of Open Access Journals (Sweden)

Susan Khor

Full Text Available Identifying reliable domain-domain interactions will increase our ability to predict novel protein-protein interactions, to unravel interactions in protein complexes, and thus gain more information about the function and behavior of genes. One of the challenges of identifying reliable domain-domain interactions is domain promiscuity. Promiscuous domains are domains that can occur in many domain architectures and are therefore found in many proteins. This becomes a problem for a method where the score of a domain-pair is the ratio between observed and expected frequencies because the protein-protein interaction network is sparse. As such, many protein-pairs will be non-interacting and domain-pairs with promiscuous domains will be penalized. This domain promiscuity challenge to the problem of inferring reliable domain-domain interactions from protein-protein interactions has been recognized, and a number of work-arounds have been proposed. This paper reports on an application of Formal Concept Analysis to this problem. It is found that the relationship between formal concepts provides a natural way for rare domains to elevate the rank of promiscuous domain-pairs and enrich highly ranked domain-pairs with reliable domain-domain interactions. This piggybacking of promiscuous domain-pairs onto less promiscuous domain-pairs is possible only with concept lattices whose attribute-labels are not reduced and is enhanced by the presence of proteins that comprise both promiscuous and rare domains.

Inferring Domain-Domain Interactions from Protein-Protein Interactions with Formal Concept Analysis

Science.gov (United States)

Khor, Susan

2014-01-01

Identifying reliable domain-domain interactions will increase our ability to predict novel protein-protein interactions, to unravel interactions in protein complexes, and thus gain more information about the function and behavior of genes. One of the challenges of identifying reliable domain-domain interactions is domain promiscuity. Promiscuous domains are domains that can occur in many domain architectures and are therefore found in many proteins. This becomes a problem for a method where the score of a domain-pair is the ratio between observed and expected frequencies because the protein-protein interaction network is sparse. As such, many protein-pairs will be non-interacting and domain-pairs with promiscuous domains will be penalized. This domain promiscuity challenge to the problem of inferring reliable domain-domain interactions from protein-protein interactions has been recognized, and a number of work-arounds have been proposed. This paper reports on an application of Formal Concept Analysis to this problem. It is found that the relationship between formal concepts provides a natural way for rare domains to elevate the rank of promiscuous domain-pairs and enrich highly ranked domain-pairs with reliable domain-domain interactions. This piggybacking of promiscuous domain-pairs onto less promiscuous domain-pairs is possible only with concept lattices whose attribute-labels are not reduced and is enhanced by the presence of proteins that comprise both promiscuous and rare domains. PMID:24586450

A residue-specific shift in stability and amyloidogenicity of antibody variable domains.

Science.gov (United States)

Nokwe, Cardine N; Zacharias, Martin; Yagi, Hisashi; Hora, Manuel; Reif, Bernd; Goto, Yuji; Buchner, Johannes

2014-09-26

Variable (V) domains of antibodies are essential for antigen recognition by our adaptive immune system. However, some variants of the light chain V domains (VL) form pathogenic amyloid fibrils in patients. It is so far unclear which residues play a key role in governing these processes. Here, we show that the conserved residue 2 of VL domains is crucial for controlling its thermodynamic stability and fibril formation. Hydrophobic side chains at position 2 stabilize the domain, whereas charged residues destabilize and lead to amyloid fibril formation. NMR experiments identified several segments within the core of the VL domain to be affected by changes in residue 2. Furthermore, molecular dynamic simulations showed that hydrophobic side chains at position 2 remain buried in a hydrophobic pocket, and charged side chains show a high flexibility. This results in a predicted difference in the dissociation free energy of ∼10 kJ mol(-1), which is in excellent agreement with our experimental values. Interestingly, this switch point is found only in VL domains of the κ family and not in VLλ or in VH domains, despite a highly similar domain architecture. Our results reveal novel insight into the architecture of variable domains and the prerequisites for formation of amyloid fibrils. This might also contribute to the rational design of stable variable antibody domains. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Full-range k-domain linearization in spectral-domain optical coherence tomography.

Science.gov (United States)

Jeon, Mansik; Kim, Jeehyun; Jung, Unsang; Lee, Changho; Jung, Woonggyu; Boppart, Stephen A

2011-03-10

A full-bandwidth k-domain linearization method for spectral-domain optical coherence tomography (SD-OCT) is demonstrated. The method uses information of the wavenumber-pixel-position provided by a translating-slit-based wavelength filter. For calibration purposes, the filter is placed either after a broadband source or at the end of the sample path, and the filtered spectrum with a narrowed line width (∼0.5 nm) is incident on a line-scan camera in the detection path. The wavelength-swept spectra are co-registered with the pixel positions according to their central wavelengths, which can be automatically measured with an optical spectrum analyzer. For imaging, the method does not require a filter or a software recalibration algorithm; it simply resamples the OCT signal from the detector array without employing rescaling or interpolation methods. The accuracy of k-linearization is maximized by increasing the k-linearization order, which is known to be a crucial parameter for maintaining a narrow point-spread function (PSF) width at increasing depths. The broadening effect is studied by changing the k-linearization order by undersampling to search for the optimal value. The system provides more position information, surpassing the optimum without compromising the imaging speed. The proposed full-range k-domain linearization method can be applied to SD-OCT systems to simplify their hardware/software, increase their speed, and improve the axial image resolution. The experimentally measured width of PSF in air has an FWHM of 8 μm at the edge of the axial measurement range. At an imaging depth of 2.5 mm, the sensitivity of the full-range calibration case drops less than 10 dB compared with the uncompensated case.

Randomised clinical trial of five ear acupuncture points for the treatment of overweight people.

Science.gov (United States)

Yeo, Sujung; Kim, Kang Sik; Lim, Sabina

2014-04-01

To evaluate the efficacy of the five ear acupuncture points (Shen-men, Spleen, Stomach, Hunger, Endocrine), generally used in Korean clinics for treating obesity, and compare them with the Hunger acupuncture point. A randomised controlled clinical trial was conducted in 91 Koreans (16 male and 75 female, body mass index (BMI)≥23), who had not received any other weight control treatment within the past 6 months. Subjects were divided randomly into treatment I, treatment II or sham control groups and received unilateral auricular acupuncture with indwelling needles replaced weekly for 8 weeks. Treatment I group received acupuncture at the five ear acupuncture points, treatment II group at the Hunger acupuncture point only and the sham control group received acupuncture at the five ear acupuncture points used in treatment I, but the needles were removed immediately after insertion. BMI, waist circumference, weight, body fat mass (BFM), percentage body fat and blood pressure were measured at baseline and at 4 and 8 weeks after treatment. For the 58 participants who provided data at 8 weeks, significant differences in BMI, weight and BFM were found between the treatment and control groups. Treatment groups I and II showed 6.1% and 5.7% reduction in BMI, respectively (pfive ear acupuncture points, generally used in Korean clinics, and the Hunger point alone treatment are both effective for treating overweight people.

Regional climate model sensitivity to domain size

Science.gov (United States)

Leduc, Martin; Laprise, René

2009-05-01

Regional climate models are increasingly used to add small-scale features that are not present in their lateral boundary conditions (LBC). It is well known that the limited area over which a model is integrated must be large enough to allow the full development of small-scale features. On the other hand, integrations on very large domains have shown important departures from the driving data, unless large scale nudging is applied. The issue of domain size is studied here by using the “perfect model” approach. This method consists first of generating a high-resolution climatic simulation, nicknamed big brother (BB), over a large domain of integration. The next step is to degrade this dataset with a low-pass filter emulating the usual coarse-resolution LBC. The filtered nesting data (FBB) are hence used to drive a set of four simulations (LBs for Little Brothers), with the same model, but on progressively smaller domain sizes. The LB statistics for a climate sample of four winter months are compared with BB over a common region. The time average (stationary) and transient-eddy standard deviation patterns of the LB atmospheric fields generally improve in terms of spatial correlation with the reference (BB) when domain gets smaller. The extraction of the small-scale features by using a spectral filter allows detecting important underestimations of the transient-eddy variability in the vicinity of the inflow boundary, which can penalize the use of small domains (less than 100 × 100 grid points). The permanent “spatial spin-up” corresponds to the characteristic distance that the large-scale flow needs to travel before developing small-scale features. The spin-up distance tends to grow in size at higher levels in the atmosphere.

Regional climate model sensitivity to domain size

Energy Technology Data Exchange (ETDEWEB)

Leduc, Martin [Universite du Quebec a Montreal, Canadian Regional Climate Modelling and Diagnostics (CRCMD) Network, ESCER Centre, Montreal (Canada); UQAM/Ouranos, Montreal, QC (Canada); Laprise, Rene [Universite du Quebec a Montreal, Canadian Regional Climate Modelling and Diagnostics (CRCMD) Network, ESCER Centre, Montreal (Canada)

2009-05-15

Regional climate models are increasingly used to add small-scale features that are not present in their lateral boundary conditions (LBC). It is well known that the limited area over which a model is integrated must be large enough to allow the full development of small-scale features. On the other hand, integrations on very large domains have shown important departures from the driving data, unless large scale nudging is applied. The issue of domain size is studied here by using the ''perfect model'' approach. This method consists first of generating a high-resolution climatic simulation, nicknamed big brother (BB), over a large domain of integration. The next step is to degrade this dataset with a low-pass filter emulating the usual coarse-resolution LBC. The filtered nesting data (FBB) are hence used to drive a set of four simulations (LBs for Little Brothers), with the same model, but on progressively smaller domain sizes. The LB statistics for a climate sample of four winter months are compared with BB over a common region. The time average (stationary) and transient-eddy standard deviation patterns of the LB atmospheric fields generally improve in terms of spatial correlation with the reference (BB) when domain gets smaller. The extraction of the small-scale features by using a spectral filter allows detecting important underestimations of the transient-eddy variability in the vicinity of the inflow boundary, which can penalize the use of small domains (less than 100 x 100 grid points). The permanent ''spatial spin-up'' corresponds to the characteristic distance that the large-scale flow needs to travel before developing small-scale features. The spin-up distance tends to grow in size at higher levels in the atmosphere. (orig.)

Solution structure and dynamics of C-terminal regulatory domain of Vibrio vulnificus extracellular metalloprotease

Energy Technology Data Exchange (ETDEWEB)

Yun, Ji-Hye; Kim, Heeyoun [Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749 (Korea, Republic of); Park, Jung Eun [Department of Biotechnology, College of Natural Sciences, Chosun University, Gwangju 501-759 (Korea, Republic of); Lee, Jung Sup, E-mail: jsplee@mail.chosun.ac.kr [Department of Biotechnology, College of Natural Sciences, Chosun University, Gwangju 501-759 (Korea, Republic of); Lee, Weontae, E-mail: wlee@spin.yonsei.ac.kr [Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749 (Korea, Republic of)

2013-01-11

Highlights: Black-Right-Pointing-Pointer We have determined solution structures of vEP C-terminal regulatory domain. Black-Right-Pointing-Pointer vEP C-ter100 has a compact {beta}-barrel structure with eight anti-parallel {beta}-strands. Black-Right-Pointing-Pointer Solution structure of vEP C-ter100 shares its molecular topology with that of the collagen-binding domain of collagenase. Black-Right-Pointing-Pointer Residues in the {beta}3 region of vEP C-ter100 might be important in putative ligand/receptor binding. Black-Right-Pointing-Pointer vEP C-ter100 interacts strongly with iron ion. -- Abstract: An extracellular metalloprotease (vEP) secreted by Vibrio vulnificus ATCC29307 is a 45-kDa proteolytic enzyme that has prothrombin activation and fibrinolytic activities during bacterial infection. The action of vEP could result in clotting that could serve to protect the bacteria from the host defense machinery. Very recently, we showed that the C-terminal propeptide (C-ter100), which is unique to vEP, is involved in regulation of vEP activity. To understand the structural basis of this function of vEP C-ter100, we have determined the solution structure and backbone dynamics using multidimensional nuclear magnetic resonance spectroscopy. The solution structure shows that vEP C-ter100 is composed of eight anti-parallel {beta}-strands with a unique fold that has a compact {beta}-barrel formation which stabilized by hydrophobic and hydrogen bonding networks. Protein dynamics shows that the overall structure, including loops, is very rigid and stabilized. By structural database analysis, we found that vEP C-ter100 shares its topology with that of the collagen-binding domain of collagenase, despite low sequence homology between the two domains. Fluorescence assay reveals that vEP C-ter100 interacts strongly with iron (Fe{sup 3+}). These findings suggest that vEP protease might recruit substrate molecules, such as collagen, by binding at C-ter100 and that vEP participates

Structural Studies of the SET Domain from RIZ1 Tumor Suppressor

Energy Technology Data Exchange (ETDEWEB)

Briknarova, Klara; Zhou, Xinliang; Satterthwait, Arnold C.; Hoyt, David W.; Ely, Kathryn R.; Huang, Shi

2008-02-15

Histone lysine methyltransferases (HKMTs) are involved in regulation of chromatin structure, and, as such, are important for longterm gene activation and repression that is associated with cell memory and establishment of cell-type specific transcriptional programs. Most HKMTs contain a SET domain, which is responsible for their catalytic activity. RIZ1 is a transcription regulator and tumor suppressor that catalyzes methylation of lysine 9 of histone H3 and contains a rather distinct SET domain. Similar SET domains, sometimes refererred to as PR (PRDI-BF1 and RIZ1 homology) domains, are also found in other proteins including Blimp-1/PRDI-BF1, MDS1-EVI1 and Meisetz. We determined the solution structure of the PR domain from RIZ1 and characterized its interaction with S-adenosyl homocysteine (SAH) and a peptide from histone H3. Despite low sequence identity with canonical SET domains, the PR domain displays a typical SET fold including a pseudo-knot at the C-terminus. The N-flanking sequence of RIZ1 PR domain adopts a novel conformation and interacts closely with the SET fold. The C-flanking sequence contains an α-helix that exhibits higher mobility than the SET fold and points away from the protein face that harbors active site in other SET domains. Residues that interact with the methylation cofactor in SET domains are not conserved in RIZ1 or other PR domains, and the SET fold of RIZ1 does not bind SAH. However, the PR domain of RIZ1 interacts specifically with a synthetic peptide comprising residues 1-20 of histone H3.

The structure of a conserved Piezo channel domain reveals a novel beta sandwich fold

Science.gov (United States)

Kamajaya, Aron; Kaiser, Jens; Lee, Jonas; Reid, Michelle; Rees, Douglas C.

2014-01-01

Summary Piezo has recently been identified as a family of eukaryotic mechanosensitive channels composed of subunits containing over 2000 amino acids, without recognizable sequence similarity to other channels. Here, we present the crystal structure of a large, conserved extramembrane domain located just before the last predicted transmembrane helix of C. elegans PIEZO, which adopts a novel beta sandwich fold. The structure was also determined of a point mutation located on a conserved surface at the position equivalent to the human PIEZO1 mutation found in Dehydrated Hereditary Stomatocytosis (DHS) patients (M2225R). While the point mutation does not change the overall domain structure, it does alter the surface electrostatic potential that may perturb interactions with a yet-to-be identified ligand or protein. The lack of structural similarity between this domain and any previously characterized fold, including those of eukaryotic and bacterial channels, highlights the distinctive nature of the Piezo family of eukaryotic mechanosensitive channels. PMID:25242456

Making Sense of the Abstraction Hierarchy in the Power Plant Domain

DEFF Research Database (Denmark)

Lind, Morten

2003-01-01

The paper discusses the abstraction hierarchy proposed by Rasmussen [(1986) Information processing and human-machine interaction, North-Holland] for design of human-machine interfaces for supervisory control. The purpose of the abstraction hierarchy is to represent a work domain by multiple levels...... of means-end and part-whole abstractions. It is argued in the paper that the abstraction hierarchy suffers from both methodological and conceptual problems. A cluster of selected problems are analyzed and illustrated by concrete examples from the power plant domain. It is concluded that the semantics...... in the model-building process. It is also pointed out that attempts to clarify the semantics of the abstraction hierarchy will invariably reduce the range of work domains where it can be applied....

Development and testing of Band 10 receivers for the ALMA project

International Nuclear Information System (INIS)

Uzawa, Y.; Fujii, Y.; Gonzalez, A.; Kaneko, K.; Kroug, M.; Kojima, T.; Kuroiwa, K.; Miyachi, A.; Saito, S.; Makise, K.; Wang, Z.; Asayama, S.

2013-01-01

Highlights: •The ALMA Band 10 (787–950 GHz) SIS receivers have been developed. •The complex conductivity of NbTiN was measured by a THz-TDS for the mixer design. •Tens of Band 10 receivers have been produced and their performance was quite well. •The best achieved receiver noise temperature was 125 K corresponding to 3hf/k B . •Band 10 receiver installed in the ALMA antenna captured astronomical signals. -- Abstract: The production model of a dual polarization heterodyne receiver for the Atacama Large Millimeter/submillimteter Array (ALMA) telescope has been developed to operate in the 787–950 GHz frequency band. The receiver uses two double sideband (DSB) waveguide mixers with Nb/AlOx/Nb tunnel junctions and NbTiN/SiO 2 /Al microstrip tuning circuits on quartz substrate. A terahertz time domain spectrometer was used to characterize our NbTiN film for the tuning circuit design, which revealed that the complex conductivity of the film is described by the Mattis-Bardeen theory including a finite scattering time of 15 fs and a superconducting gap with a gap ratio 2Δ/k B T C ∼ 4.0. Tens of these receivers (out of the total production number of 73) have been successfully produced, and their performance is well within the stringent ALMA requirements. The best achieved DSB receiver noise temperature is 125 K, corresponding to about 3hf/k B for 4 K operation. One of Band 10 receivers has successfully been installed in the ALMA antenna for a test observation

Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects

Directory of Open Access Journals (Sweden)

Carmen L. Bayly

2017-02-01

Full Text Available Modular polyketide synthases (mPKSs build functionalized polymeric chains, some of which have become blockbuster therapeutics. Organized into repeating clusters (modules of independently-folding domains, these assembly-line-like megasynthases can be engineered by introducing non-native components. However, poor introduction points and incompatible domain combinations can cause both unintended products and dramatically reduced activity. This limits the engineering and combinatorial potential of mPKSs, precluding access to further potential therapeutics. Different regions on a given mPKS domain determine how it interacts both with its substrate and with other domains. Within the assembly line, these interactions are crucial to the proper ordering of reactions and efficient polyketide construction. Achieving control over these domain functions, through precision engineering at key regions, would greatly expand our catalogue of accessible polyketide products. Canonical mPKS domains, given that they are among the most well-characterized, are excellent candidates for such fine-tuning. The current minireview summarizes recent advances in the mechanistic understanding and subsequent precision engineering of canonical mPKS domains, focusing largely on developments in the past year.

Material-Point Analysis of Large-Strain Problems

DEFF Research Database (Denmark)

Andersen, Søren

The aim of this thesis is to apply and improve the material-point method for modelling of geotechnical problems. One of the geotechnical phenomena that is a subject of active research is the study of landslides. A large amount of research is focused on determining when slopes become unstable. Hence......, it is possible to predict if a certain slope is stable using commercial finite element or finite difference software such as PLAXIS, ABAQUS or FLAC. However, the dynamics during a landslide are less explored. The material-point method (MPM) is a novel numerical method aimed at analysing problems involving...... materials subjected to large strains in a dynamical time–space domain. This thesis explores the material-point method with the specific aim of improving the performance for geotechnical problems. Large-strain geotechnical problems such as landslides pose a major challenge to model numerically. Employing...

On the Equational Definition of the Least Prefixed Point

DEFF Research Database (Denmark)

Santocanale, Luigi

2003-01-01

We propose a method to axiomatize by equations the least prefixed point of an order preserving function. We discuss its domain of application and show that the Boolean modal μ-calculus has a complete equational axiomatization. The method relies on the existence of a “closed structure” and its rel...

76 FR 58122 - Defense Federal Acquisition Regulation Supplement; Material Inspection and Receiving Report...

Science.gov (United States)

2011-09-20

... acceptance point and replacing it with more specific data entries for inspection, acceptance, and ship to Do..., acceptance, and ship-to fields but kept the source, destination, and other inspection and acceptance points... Acquisition Regulation Supplement; Material Inspection and Receiving Report (DFARS Case 2009-D023) AGENCY...

Interest point detection for hyperspectral imagery

Science.gov (United States)

Dorado-Muñoz, Leidy P.; Vélez-Reyes, Miguel; Roysam, Badrinath; Mukherjee, Amit

2009-05-01

This paper presents an algorithm for automated extraction of interest points (IPs)in multispectral and hyperspectral images. Interest points are features of the image that capture information from its neighbours and they are distinctive and stable under transformations such as translation and rotation. Interest-point operators for monochromatic images were proposed more than a decade ago and have since been studied extensively. IPs have been applied to diverse problems in computer vision, including image matching, recognition, registration, 3D reconstruction, change detection, and content-based image retrieval. Interest points are helpful in data reduction, and reduce the computational burden of various algorithms (like registration, object detection, 3D reconstruction etc) by replacing an exhaustive search over the entire image domain by a probe into a concise set of highly informative points. An interest operator seeks out points in an image that are structurally distinct, invariant to imaging conditions, stable under geometric transformation, and interpretable which are good candidates for interest points. Our approach extends ideas from Lowe's keypoint operator that uses local extrema of Difference of Gaussian (DoG) operator at multiple scales to detect interest point in gray level images. The proposed approach extends Lowe's method by direct conversion of scalar operations such as scale-space generation, and extreme point detection into operations that take the vector nature of the image into consideration. Experimental results with RGB and hyperspectral images which demonstrate the potential of the method for this application and the potential improvements of a fully vectorial approach over band-by-band approaches described in the literature.

Receiver based PAPR reduction in OFDMA

KAUST Repository

Ali, Anum Z.; Al-Zahrani, Ali Y.; Al-Naffouri, Tareq Y.; Naguib, Ayman F.

2014-01-01

High peak-to-average power ratio is one of the major drawbacks of orthogonal frequency division multiplexing (OFDM). Clipping is the simplest peak reduction scheme, however, it requires clipping mitigation at the receiver. Recently compressed sensing has been used for clipping mitigation (by exploiting the sparse nature of clipping signal). However, clipping estimation in multi-user scenario (i.e., OFDMA) is not straightforward as clipping distortions overlap in frequency domain and one cannot distinguish between distortions from different users. In this work, a collaborative clipping removal strategy is proposed based on joint estimation of the clipping distortions from all users. Further, an effective data aided channel estimation strategy for clipped OFDM is also outlined. Simulation results are presented to justify the effectiveness of the proposed schemes. © 2014 IEEE.

Receiver based PAPR reduction in OFDMA

KAUST Repository

Ali, Anum Z.

2014-05-01

High peak-to-average power ratio is one of the major drawbacks of orthogonal frequency division multiplexing (OFDM). Clipping is the simplest peak reduction scheme, however, it requires clipping mitigation at the receiver. Recently compressed sensing has been used for clipping mitigation (by exploiting the sparse nature of clipping signal). However, clipping estimation in multi-user scenario (i.e., OFDMA) is not straightforward as clipping distortions overlap in frequency domain and one cannot distinguish between distortions from different users. In this work, a collaborative clipping removal strategy is proposed based on joint estimation of the clipping distortions from all users. Further, an effective data aided channel estimation strategy for clipped OFDM is also outlined. Simulation results are presented to justify the effectiveness of the proposed schemes. © 2014 IEEE.

A TR-UWB Downconversion Autocorrelation Receiver for Wireless Body Area Network

Directory of Open Access Journals (Sweden)

Islam SMRiazul

2009-01-01

Full Text Available Low power UWB receiver architecture is proposed for a Wireless Body Area Network (WBAN. This receiving technology is a synergy of existing downconversion-based narrowband rejection mechanism in RF front end and signal processing in frequency domain. Frequency components of converted and filtered UWB pulses are separated into real and imaginary parts, independently correlated and effectively combined to achieve an improved output Signal to noise ratio (SNR. An extensive mathematical analysis has been performed to formulate the close-form expressions for SNRs in order to compare system performances toward favorable BER under BPSK modulation scheme. Analysis shows that optimal rotation of coordination plays an important role for the enhancement of receiving SNR which is further confirmed by computer simulation. A wide range of link level simulation (LLS urges that the proposed system is more power efficient in higher-order modulation (HOM schemes. Transmitted Reference (TR scheme has been considered as the basis for wideband communication.

B-spline Collocation with Domain Decomposition Method

International Nuclear Information System (INIS)

Hidayat, M I P; Parman, S; Ariwahjoedi, B

2013-01-01

A global B-spline collocation method has been previously developed and successfully implemented by the present authors for solving elliptic partial differential equations in arbitrary complex domains. However, the global B-spline approximation, which is simply reduced to Bezier approximation of any degree p with C 0 continuity, has led to the use of B-spline basis of high order in order to achieve high accuracy. The need for B-spline bases of high order in the global method would be more prominent in domains of large dimension. For the increased collocation points, it may also lead to the ill-conditioning problem. In this study, overlapping domain decomposition of multiplicative Schwarz algorithm is combined with the global method. Our objective is two-fold that improving the accuracy with the combination technique, and also investigating influence of the combination technique to the employed B-spline basis orders with respect to the obtained accuracy. It was shown that the combination method produced higher accuracy with the B-spline basis of much lower order than that needed in implementation of the initial method. Hence, the approximation stability of the B-spline collocation method was also increased.

The consequences of chronic stereotype threat: domain disidentification and abandonment.

Science.gov (United States)

Woodcock, Anna; Hernandez, Paul R; Estrada, Mica; Schultz, P Wesley

2012-10-01

Stereotype threat impairs performance across many domains. Despite a wealth of research, the long-term consequences of chronic stereotype threat have received little empirical attention. Beyond the immediate impact on performance, the experience of chronic stereotype threat is hypothesized to lead to domain disidentification and eventual domain abandonment. Stereotype threat is 1 explanation why African Americans and Hispanic/Latino(a)s "leak" from each juncture of the academic scientific pipeline in disproportionately greater numbers than their White and Asian counterparts. Using structural equation modeling, we tested the stereotype threat-disidentification hypothesis across 3 academic years with a national longitudinal panel of undergraduate minority science students. Experience of stereotype threat was associated with scientific disidentification, which in turn predicted a significant decline in the intention to pursue a scientific career. Race/ethnicity moderated this effect, whereby the effect was evident for Hispanic/Latino(a) students but not for all African American students. We discuss findings in terms of understanding chronic stereotype threat.

Enhanced production of a single domain antibody with an engineered stabilizing extra disulfide bond.

Science.gov (United States)

Liu, Jinny L; Goldman, Ellen R; Zabetakis, Dan; Walper, Scott A; Turner, Kendrick B; Shriver-Lake, Lisa C; Anderson, George P

2015-10-09

Single domain antibodies derived from the variable region of the unique heavy chain antibodies found in camelids yield high affinity and regenerable recognition elements. Adding an additional disulfide bond that bridges framework regions is a proven method to increase their melting temperature, however often at the expense of protein production. To fulfill their full potential it is essential to achieve robust protein production of these stable binding elements. In this work, we tested the hypothesis that decreasing the isoelectric point of single domain antibody extra disulfide bond mutants whose production fell due to the incorporation of the extra disulfide bond would lead to recovery of the protein yield, while maintaining the favorable melting temperature and affinity. Introduction of negative charges into a disulfide bond mutant of a single domain antibody specific for the L1 antigen of the vaccinia virus led to approximately 3.5-fold increase of protein production to 14 mg/L, while affinity and melting temperature was maintained. In addition, refolding following heat denaturation improved from 15 to 70 %. It also maintained nearly 100 % of its binding function after heating to 85 °C for an hour at 1 mg/mL. Disappointingly, the replacement of neutral or positively charged amino acids with negatively charged ones to lower the isoelectric point of two anti-toxin single domain antibodies stabilized with a second disulfide bond yielded only slight increases in protein production. Nonetheless, for one of these binders the charge change itself stabilized the structure equivalent to disulfide bond addition, thus providing an alternative route to stabilization which is not accompanied by loss in production. The ability to produce high affinity, stable single domain antibodies is critical for their utility. While the addition of a second disulfide bond is a proven method for enhancing stability of single domain antibodies, it frequently comes at the cost of reduced

MIN-CUT BASED SEGMENTATION OF AIRBORNE LIDAR POINT CLOUDS

Directory of Open Access Journals (Sweden)

S. Ural

2012-07-01

Full Text Available Introducing an organization to the unstructured point cloud before extracting information from airborne lidar data is common in many applications. Aggregating the points with similar features into segments in 3-D which comply with the nature of actual objects is affected by the neighborhood, scale, features and noise among other aspects. In this study, we present a min-cut based method for segmenting the point cloud. We first assess the neighborhood of each point in 3-D by investigating the local geometric and statistical properties of the candidates. Neighborhood selection is essential since point features are calculated within their local neighborhood. Following neighborhood determination, we calculate point features and determine the clusters in the feature space. We adapt a graph representation from image processing which is especially used in pixel labeling problems and establish it for the unstructured 3-D point clouds. The edges of the graph that are connecting the points with each other and nodes representing feature clusters hold the smoothness costs in the spatial domain and data costs in the feature domain. Smoothness costs ensure spatial coherence, while data costs control the consistency with the representative feature clusters. This graph representation formalizes the segmentation task as an energy minimization problem. It allows the implementation of an approximate solution by min-cuts for a global minimum of this NP hard minimization problem in low order polynomial time. We test our method with airborne lidar point cloud acquired with maximum planned post spacing of 1.4 m and a vertical accuracy 10.5 cm as RMSE. We present the effects of neighborhood and feature determination in the segmentation results and assess the accuracy and efficiency of the implemented min-cut algorithm as well as its sensitivity to the parameters of the smoothness and data cost functions. We find that smoothness cost that only considers simple distance

Parallel finite elements with domain decomposition and its pre-processing

International Nuclear Information System (INIS)

Yoshida, A.; Yagawa, G.; Hamada, S.

1993-01-01

This paper describes a parallel finite element analysis using a domain decomposition method, and the pre-processing for the parallel calculation. Computer simulations are about to replace experiments in various fields, and the scale of model to be simulated tends to be extremely large. On the other hand, computational environment has drastically changed in these years. Especially, parallel processing on massively parallel computers or computer networks is considered to be promising techniques. In order to achieve high efficiency on such parallel computation environment, large granularity of tasks, a well-balanced workload distribution are key issues. It is also important to reduce the cost of pre-processing in such parallel FEM. From the point of view, the authors developed the domain decomposition FEM with the automatic and dynamic task-allocation mechanism and the automatic mesh generation/domain subdivision system for it. (author)

The YARHG domain: an extracellular domain in search of a function.

Directory of Open Access Journals (Sweden)

Penny Coggill

Full Text Available We have identified a new bacterial protein domain that we hypothesise binds to peptidoglycan. This domain is called the YARHG domain after the most highly conserved sequence-segment. The domain is found in the extracellular space and is likely to be composed of four alpha-helices. The domain is found associated with protein kinase domains, suggesting it is associated with signalling in some bacteria. The domain is also found associated with three different families of peptidases. The large number of different domains that are found associated with YARHG suggests that it is a useful functional module that nature has recombined multiple times.

Fate of triclosan in field soils receiving sewage sludge

Energy Technology Data Exchange (ETDEWEB)

Butler, E [Department of Environmental Science and Technology, School of Applied Sciences, Cranfield University, College Road, Cranfield, Bedfordshire MK43 0AL (United Kingdom); Whelan, M J; Sakrabani, R [Department of Environmental Science and Technology, School of Applied Sciences, Cranfield University, College Road, Cranfield, Bedfordshire MK43 0AL (United Kingdom); Egmond, R van [Safety and Environmental Assurance Centre, Unilever Colworth Laboratory, Colworth Park, Sharnbrook, Bedfordshire MK44 1LQ (United Kingdom)

2012-08-15

The anti-microbial substance triclosan can partition to sewage sludge during wastewater treatment and subsequently transfer to soil when applied to land. Here, we describe the fate of triclosan in a one-year plot experiment on three different soils receiving sludge. Triclosan and methyl-triclosan concentrations were measured in soil samples collected monthly from three depths. A large fraction of triclosan loss appeared to be explained by transformation to methyl-triclosan. After 12 months less than 20% of the initial triclosan was recovered from each soil. However, the majority was recovered as methyl-triclosan. Most of the chemical recovered at the end of the experiment (both triclosan and methyl-triclosan) was still in the top 10 cm layer, although there was translocation to lower soil horizons in all three soils. Between 16.5 and 50.6% of the applied triclosan was unaccounted for after 12 months either as a consequence of degradation or the formation of non-extractable residues. - Highlights: Black-Right-Pointing-Pointer We study the fate of triclosan in 3 different field soils amended with biosolids. Black-Right-Pointing-Pointer Triclosan concentrations were measured over 12 months at 3 depths of soil. Black-Right-Pointing-Pointer Methyl-triclosan was identified as a main biotransformation product. Black-Right-Pointing-Pointer There was very little movement of triclosan through the soil. Black-Right-Pointing-Pointer Only between 16 and 50% of triclosan applied was degraded or leached out of the soil. - This paper investigates the mobility and degradation of triclosan in three field soils after receiving an application of biosolids and the persistence of methyl-triclosan.

The local domain wall position in ferromagnetic thin wires: simultaneous measurement of resistive and transverse voltages at multiple points

International Nuclear Information System (INIS)

Hanada, R.; Sugawara, H.; Aoki, Y.; Sato, H.; Shigeto, K.; Shinjo, T.; Ono, T.; Miyajima, H.

2002-01-01

We have simultaneously measured the field dependences of voltages at multiple pairs of resistance and transverse voltage probes in ferromagnetic wires (with either magnetic or non-magnetic voltage probes). Both the resistive (through the giant magnetoresistance and anisotropic magnetoresistance) and transverse voltages (through the planar Hall effect) exhibit abrupt jumps, reflecting discrete motion of domain walls or rotations of magnetization. Voltage probes, even if non-magnetic, are found to affect the jump fields depending on the sample conditions. We demonstrate that the specific information on the domain (wall) motion along a thin ferromagnetic wire could be obtained from the jump fields. (author)

Super-Grid Modeling of the Elastic Wave Equation in Semi-Bounded Domains

Energy Technology Data Exchange (ETDEWEB)

Petersson, N. Anders; Sjögreen, Björn

2014-10-01

We develop a super-grid modeling technique for solving the elastic wave equation in semi-bounded two- and three-dimensional spatial domains. In this method, waves are slowed down and dissipated in sponge layers near the far-field boundaries. Mathematically, this is equivalent to a coordinate mapping that transforms a very large physical domain to a significantly smaller computational domain, where the elastic wave equation is solved numerically on a regular grid. To damp out waves that become poorly resolved because of the coordinate mapping, a high order artificial dissipation operator is added in layers near the boundaries of the computational domain. We prove by energy estimates that the super-grid modeling leads to a stable numerical method with decreasing energy, which is valid for heterogeneous material properties and a free surface boundary condition on one side of the domain. Our spatial discretization is based on a fourth order accurate finite difference method, which satisfies the principle of summation by parts. We show that the discrete energy estimate holds also when a centered finite difference stencil is combined with homogeneous Dirichlet conditions at several ghost points outside of the far-field boundaries. Therefore, the coefficients in the finite difference stencils need only be boundary modified near the free surface. This allows for improved computational efficiency and significant simplifications of the implementation of the proposed method in multi-dimensional domains. Numerical experiments in three space dimensions show that the modeling error from truncating the domain can be made very small by choosing a sufficiently wide super-grid damping layer. The numerical accuracy is first evaluated against analytical solutions of Lamb’s problem, where fourth order accuracy is observed with a sixth order artificial dissipation. We then use successive grid refinements to study the numerical accuracy in the more

Crystal structure of the Candida albicans Kar3 kinesin motor domain fused to maltose-binding protein

Energy Technology Data Exchange (ETDEWEB)

Delorme, Caroline; Joshi, Monika [Department of Biomedical and Molecular Sciences, Queen' s University, Kingston, ON, Canada K7L 3N6 (Canada); Allingham, John S., E-mail: allinghj@queensu.ca [Department of Biomedical and Molecular Sciences, Queen' s University, Kingston, ON, Canada K7L 3N6 (Canada)

2012-11-30

Highlights: Black-Right-Pointing-Pointer The Candida albicans Kar3 motor domain structure was solved as a maltose-binding protein fusion. Black-Right-Pointing-Pointer The electrostatic surface and part of the ATPase pocket of the motor domain differs markedly from other kinesins. Black-Right-Pointing-Pointer The MBP-Kar3 interface highlights a new site for intramolecular or intermolecular interactions. -- Abstract: In the human fungal pathogen Candida albicans, the Kinesin-14 motor protein Kar3 (CaKar3) is critical for normal mitotic division, nuclear fusion during mating, and morphogenic transition from the commensal yeast form to the virulent hyphal form. As a first step towards detailed characterization of this motor of potential medical significance, we have crystallized and determined the X-ray structure of the motor domain of CaKar3 as a maltose-binding protein (MBP) fusion. The structure shows strong conservation of overall motor domain topology to other Kar3 kinesins, but with some prominent differences in one of the motifs that compose the nucleotide-binding pocket and the surface charge distribution. The MBP and Kar3 modules are arranged such that MBP interacts with the Kar3 motor domain core at the same site where the neck linker of conventional kinesins docks during the 'ATP state' of the mechanochemical cycle. This site differs from the Kar3 neck-core interface in the recent structure of the ScKar3Vik1 heterodimer. The position of MBP is also completely distinct from the Vik1 subunit in this complex. This may suggest that the site of MBP interaction on the CaKar3 motor domain provides an interface for the neck, or perhaps a partner subunit, at an intermediate state of its motile cycle that has not yet been observed for Kinesin-14 motors.

Convergence of Wachspress coordinates: from polygons to curved domains

KAUST Repository

Kosinka, Jiří

2014-08-08

Given a smooth, strictly convex planar domain, we investigate point-wise convergence of the sequence of Wachspress coordinates defined over finer and finer inscribed polygonal approximations of the domain. Based on a relation between the discrete Wachspress case and the limit smooth case given by the Wachspress kernel defined by Warren et al., we show that the corresponding sequences of Wachspress interpolants and mappings converge as 𝓞(h2) for a sampling step size h of the boundary curve of the domain as h → 0. Several examples are shown to numerically validate the results and to visualise the behaviour of discrete interpolants and mappings as they converge to their smooth counterparts. Empirically, the same convergence order is observed also for mean value coordinates. Moreover, our numerical tests suggest that the convergence of interpolants and mappings is uniform both in the Wachspress and mean value cases. © 2014 Springer Science+Business Media New York.

Convergence of Wachspress coordinates: from polygons to curved domains

KAUST Repository

Kosinka, Jiří ; Barton, Michael

2014-01-01

Given a smooth, strictly convex planar domain, we investigate point-wise convergence of the sequence of Wachspress coordinates defined over finer and finer inscribed polygonal approximations of the domain. Based on a relation between the discrete Wachspress case and the limit smooth case given by the Wachspress kernel defined by Warren et al., we show that the corresponding sequences of Wachspress interpolants and mappings converge as 𝓞(h2) for a sampling step size h of the boundary curve of the domain as h → 0. Several examples are shown to numerically validate the results and to visualise the behaviour of discrete interpolants and mappings as they converge to their smooth counterparts. Empirically, the same convergence order is observed also for mean value coordinates. Moreover, our numerical tests suggest that the convergence of interpolants and mappings is uniform both in the Wachspress and mean value cases. © 2014 Springer Science+Business Media New York.

24 CFR 902.47 - Management operations portion of total PHAS points.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Management operations portion of... Operations § 902.47 Management operations portion of total PHAS points. Of the total 100 points available for a PHAS score, a PHA may receive up to 30 points based on the Management Operations Indicator. ...

.Gov Domains API

Data.gov (United States)

General Services Administration — This dataset offers the list of all .gov domains, including state, local, and tribal .gov domains. It does not include .mil domains, or other federal domains outside...

A Space Object Detection Algorithm using Fourier Domain Likelihood Ratio Test

Science.gov (United States)

Becker, D.; Cain, S.

Space object detection is of great importance in the highly dependent yet competitive and congested space domain. Detection algorithms employed play a crucial role in fulfilling the detection component in the situational awareness mission to detect, track, characterize and catalog unknown space objects. Many current space detection algorithms use a matched filter or a spatial correlator to make a detection decision at a single pixel point of a spatial image based on the assumption that the data follows a Gaussian distribution. This paper explores the potential for detection performance advantages when operating in the Fourier domain of long exposure images of small and/or dim space objects from ground based telescopes. A binary hypothesis test is developed based on the joint probability distribution function of the image under the hypothesis that an object is present and under the hypothesis that the image only contains background noise. The detection algorithm tests each pixel point of the Fourier transformed images to make the determination if an object is present based on the criteria threshold found in the likelihood ratio test. Using simulated data, the performance of the Fourier domain detection algorithm is compared to the current algorithm used in space situational awareness applications to evaluate its value.

The first transmembrane domain (TM1) of β2-subunit binds to the transmembrane domain S1 of α-subunit in BK potassium channels

Science.gov (United States)

Morera, Francisco J.; Alioua, Abderrahmane; Kundu, Pallob; Salazar, Marcelo; Gonzalez, Carlos; Martinez, Agustin D.; Stefani, Enrico; Toro, Ligia; Latorre, Ramon

2012-01-01

The BK channel is one of the most broadly expressed ion channels in mammals. In many tissues, the BK channel pore-forming α-subunit is associated to an auxiliary β-subunit that modulates the voltage- and Ca2+-dependent activation of the channel. Structural components present in β-subunits that are important for the physical association with the α-subunit are yet unknown. Here, we show through co-immunoprecipitation that the intracellular C-terminus, the second transmembrane domain (TM2) and the extracellular loop of the β2-subunit are dispensable for association with the α-subunit pointing transmembrane domain 1 (TM1) as responsible for the interaction. Indeed, the TOXCAT assay for transmembrane protein–protein interactions demonstrated for the first time that TM1 of the β2-subunit physically binds to the transmembrane S1 domain of the α-subunit. PMID:22710124

Discrete quark-lepton symmetry need not pose a cosmological domain wall problem

International Nuclear Information System (INIS)

Lew, H.; Volkas, R.R.

1992-01-01

Quarks and leptons may be related to each other through a spontaneously broken discrete symmetry. Models with acceptable and interesting collider phenomenology have been constructed which incorporate this idea. However, the standard Hot Big Bang model of cosmology is generally considered to eschew spontaneously broken discrete symmetries because they often lead to the formation of unacceptably massive domain walls. It is pointed out that there are a number of plausible quark-lepton symmetric models in nature which do not produce cosmologically troublesome domain walls. 30 refs

Books Received

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education. Books Received. Articles in Resonance – Journal of Science Education. Volume 1 Issue 1 January 1996 pp 118-118 Books Received. Books Received · More Details Fulltext PDF. Volume 1 Issue 2 February 1996 pp 120-120 Books Received. Books Received.

Same but not alike: Structure, flexibility and energetics of domains in multi-domain proteins are influenced by the presence of other domains.

Science.gov (United States)

Vishwanath, Sneha; de Brevern, Alexandre G; Srinivasan, Narayanaswamy

2018-02-01

The majority of the proteins encoded in the genomes of eukaryotes contain more than one domain. Reasons for high prevalence of multi-domain proteins in various organisms have been attributed to higher stability and functional and folding advantages over single-domain proteins. Despite these advantages, many proteins are composed of only one domain while their homologous domains are part of multi-domain proteins. In the study presented here, differences in the properties of protein domains in single-domain and multi-domain systems and their influence on functions are discussed. We studied 20 pairs of identical protein domains, which were crystallized in two forms (a) tethered to other proteins domains and (b) tethered to fewer protein domains than (a) or not tethered to any protein domain. Results suggest that tethering of domains in multi-domain proteins influences the structural, dynamic and energetic properties of the constituent protein domains. 50% of the protein domain pairs show significant structural deviations while 90% of the protein domain pairs show differences in dynamics and 12% of the residues show differences in the energetics. To gain further insights on the influence of tethering on the function of the domains, 4 pairs of homologous protein domains, where one of them is a full-length single-domain protein and the other protein domain is a part of a multi-domain protein, were studied. Analyses showed that identical and structurally equivalent functional residues show differential dynamics in homologous protein domains; though comparable dynamics between in-silico generated chimera protein and multi-domain proteins were observed. From these observations, the differences observed in the functions of homologous proteins could be attributed to the presence of tethered domain. Overall, we conclude that tethered domains in multi-domain proteins not only provide stability or folding advantages but also influence pathways resulting in differences in

On a Paneitz type equation in six dimensional domains

International Nuclear Information System (INIS)

Chtioui, Hichem; El Mehdi, Khalil

2003-09-01

In this paper, we consider the equation Δ 2 u = Ku 5 , u > 0 in Ω, u = Δu = 0 on ∂Ω, where K is a positive function and Ω is a bounded and smooth domain in R 6 . Using the theory of critical points at infinity, we give some topological conditions on K to ensure some existence results. (author)

Exceptional points near first- and second-order quantum phase transitions.

Science.gov (United States)

Stránský, Pavel; Dvořák, Martin; Cejnar, Pavel

2018-01-01

We study the impact of quantum phase transitions (QPTs) on the distribution of exceptional points (EPs) of the Hamiltonian in the complex-extended parameter domain. Analyzing first- and second-order QPTs in the Lipkin-Meshkov-Glick model we find an exponentially and polynomially close approach of EPs to the respective critical point with increasing size of the system. If the critical Hamiltonian is subject to random perturbations of various kinds, the averaged distribution of EPs close to the critical point still carries decisive information on the QPT type. We therefore claim that properties of the EP distribution represent a parametrization-independent signature of criticality in quantum systems.

Collaborative Indoor Access Point Localization Using Autonomous Mobile Robot Swarm.

Science.gov (United States)

Awad, Fahed; Naserllah, Muhammad; Omar, Ammar; Abu-Hantash, Alaa; Al-Taj, Abrar

2018-01-31

Localization of access points has become an important research problem due to the wide range of applications it addresses such as dismantling critical security threats caused by rogue access points or optimizing wireless coverage of access points within a service area. Existing proposed solutions have mostly relied on theoretical hypotheses or computer simulation to demonstrate the efficiency of their methods. The techniques that rely on estimating the distance using samples of the received signal strength usually assume prior knowledge of the signal propagation characteristics of the indoor environment in hand and tend to take a relatively large number of uniformly distributed random samples. This paper presents an efficient and practical collaborative approach to detect the location of an access point in an indoor environment without any prior knowledge of the environment. The proposed approach comprises a swarm of wirelessly connected mobile robots that collaboratively and autonomously collect a relatively small number of non-uniformly distributed random samples of the access point's received signal strength. These samples are used to efficiently and accurately estimate the location of the access point. The experimental testing verified that the proposed approach can identify the location of the access point in an accurate and efficient manner.

Theoretical study on phase coexistence in ferroelectric solid solutions near the tricritical point

Energy Technology Data Exchange (ETDEWEB)

Lu, Xiaoyan, E-mail: luxy@hit.edu.cn, E-mail: dzk@psu.edu; Li, Hui [Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education, School of Civil Engineering, Harbin Institute of Technology, Harbin 150001 (China); Zheng, Limei [Condensed Matter Science and Technology Institute, Harbin Institute of Technology, Harbin 150001 (China); Cao, Wenwu [Condensed Matter Science and Technology Institute, Harbin Institute of Technology, Harbin 150001 (China); Department of Mathematics and Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802 (United States)

2015-04-07

Phase coexistence in ferroelectric solid solutions near the tricritical point has been theoretically analyzed by using the Landau-Devonshire theory. Results revealed that different phases having similar potential wells could coexist in a narrow composition range near the tricritical point in the classical Pb(Zr{sub 1−x}Ti{sub x})O{sub 3} system. The potential barrier between potential wells increases with the decrease of temperature. Coexisting phases or different domains of the same phase can produce adaptive strains to maintain atomic coherency at the interfaces or domain walls. Such compatibility strains have influence on the energy potential as well as the stability of relative phases, leading to the appearance of energetically unfavorable monoclinic phases. Those competing and coexisting phases also construct an easy phase transition path with small energy barrier in between, so that very small stimuli can produce large response in compositions near the morphotropic phase boundary, especially near the tricritical point.

Theoretical study on phase coexistence in ferroelectric solid solutions near the tricritical point

International Nuclear Information System (INIS)

Lu, Xiaoyan; Li, Hui; Zheng, Limei; Cao, Wenwu

2015-01-01

Phase coexistence in ferroelectric solid solutions near the tricritical point has been theoretically analyzed by using the Landau-Devonshire theory. Results revealed that different phases having similar potential wells could coexist in a narrow composition range near the tricritical point in the classical Pb(Zr 1−x Ti x )O 3 system. The potential barrier between potential wells increases with the decrease of temperature. Coexisting phases or different domains of the same phase can produce adaptive strains to maintain atomic coherency at the interfaces or domain walls. Such compatibility strains have influence on the energy potential as well as the stability of relative phases, leading to the appearance of energetically unfavorable monoclinic phases. Those competing and coexisting phases also construct an easy phase transition path with small energy barrier in between, so that very small stimuli can produce large response in compositions near the morphotropic phase boundary, especially near the tricritical point

Assessment of spanwise domain size effect on the transitional flow past an airfoil

KAUST Repository

Zhang, Wei

2015-10-19

In most large-eddy and direct numerical simulations of flow past an isolated airfoil, the flow is assumed periodic in the spanwise direction. The size of the spanwise domain is an important geometrical parameter determining whether the turbulent flow is fully developed, and whether the separation and transition patterns are accurately modeled. In the present study, we investigate the incompressible flow past an isolated NACA0012 airfoil at the angle of attack of 5 degrees and Reynolds number 5 × 104. The spanwise domain size Lz, represented by the aspect ratio AR=Lz/C where C is the airfoil chord length, is varied in the range 0.1−0.80.1−0.8. The effect of varying the normalized spanwise domain size AR is examined via direct numerical simulation (DNS) on several aspects of the turbulent flow quantities including the time-averaged and time-dependent behavior as well as the spanwise variation of the selected statistical quantities. DNS results reveal that different aspect ratios result in close predictions of the time-averaged aerodynamic quantities, and the velocity field except for a slight difference in the separation bubble. Smaller aspect ratios tend to underpredict the turbulent fluctuations near the separation point but overpredict them inside the separation bubble. Large differences are observed for multiple statistical quantities near the reattachment point, especially the turbulent kinetic energy budget terms. The leading edge separation is notably three-dimensional for simulation at AR=0.8, while remaining quasi-2D for smaller aspect ratios. The spanwise two-point correlation coefficient shows significant dependence on the position of the probe and the velocity component analyzed: small aspect ratios do not produce uncorrelated results for all the velocity components. The simulation results demonstrate that examining only a few statistical quantities may result in a misleading conclusion regarding the sufficiency of the spanwise domain size. Reliable

Assessment of spanwise domain size effect on the transitional flow past an airfoil

KAUST Repository

Zhang, Wei; Samtaney, Ravi

2015-01-01

In most large-eddy and direct numerical simulations of flow past an isolated airfoil, the flow is assumed periodic in the spanwise direction. The size of the spanwise domain is an important geometrical parameter determining whether the turbulent flow is fully developed, and whether the separation and transition patterns are accurately modeled. In the present study, we investigate the incompressible flow past an isolated NACA0012 airfoil at the angle of attack of 5 degrees and Reynolds number 5 × 104. The spanwise domain size Lz, represented by the aspect ratio AR=Lz/C where C is the airfoil chord length, is varied in the range 0.1−0.80.1−0.8. The effect of varying the normalized spanwise domain size AR is examined via direct numerical simulation (DNS) on several aspects of the turbulent flow quantities including the time-averaged and time-dependent behavior as well as the spanwise variation of the selected statistical quantities. DNS results reveal that different aspect ratios result in close predictions of the time-averaged aerodynamic quantities, and the velocity field except for a slight difference in the separation bubble. Smaller aspect ratios tend to underpredict the turbulent fluctuations near the separation point but overpredict them inside the separation bubble. Large differences are observed for multiple statistical quantities near the reattachment point, especially the turbulent kinetic energy budget terms. The leading edge separation is notably three-dimensional for simulation at AR=0.8, while remaining quasi-2D for smaller aspect ratios. The spanwise two-point correlation coefficient shows significant dependence on the position of the probe and the velocity component analyzed: small aspect ratios do not produce uncorrelated results for all the velocity components. The simulation results demonstrate that examining only a few statistical quantities may result in a misleading conclusion regarding the sufficiency of the spanwise domain size. Reliable

Development and testing of Band 10 receivers for the ALMA project

Energy Technology Data Exchange (ETDEWEB)

Uzawa, Y., E-mail: y.uzawa@nao.ac.jp [National Astronomical Observatory, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Fujii, Y.; Gonzalez, A.; Kaneko, K.; Kroug, M.; Kojima, T.; Kuroiwa, K.; Miyachi, A. [National Astronomical Observatory, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Saito, S.; Makise, K.; Wang, Z. [National Institute of Information and Telecommunications Technology, 588-2 Iwaoka, Iwaoka-cho, Kobe, Hyogo 651-2492 (Japan); Asayama, S. [Joint ALMA Observatory, Alonso de Cordova 3107, Vitacura, Santiago (Chile)

2013-11-15

Highlights: •The ALMA Band 10 (787–950 GHz) SIS receivers have been developed. •The complex conductivity of NbTiN was measured by a THz-TDS for the mixer design. •Tens of Band 10 receivers have been produced and their performance was quite well. •The best achieved receiver noise temperature was 125 K corresponding to 3hf/k{sub B}. •Band 10 receiver installed in the ALMA antenna captured astronomical signals. -- Abstract: The production model of a dual polarization heterodyne receiver for the Atacama Large Millimeter/submillimteter Array (ALMA) telescope has been developed to operate in the 787–950 GHz frequency band. The receiver uses two double sideband (DSB) waveguide mixers with Nb/AlOx/Nb tunnel junctions and NbTiN/SiO{sub 2}/Al microstrip tuning circuits on quartz substrate. A terahertz time domain spectrometer was used to characterize our NbTiN film for the tuning circuit design, which revealed that the complex conductivity of the film is described by the Mattis-Bardeen theory including a finite scattering time of 15 fs and a superconducting gap with a gap ratio 2Δ/k{sub B}T{sub C} ∼ 4.0. Tens of these receivers (out of the total production number of 73) have been successfully produced, and their performance is well within the stringent ALMA requirements. The best achieved DSB receiver noise temperature is 125 K, corresponding to about 3hf/k{sub B} for 4 K operation. One of Band 10 receivers has successfully been installed in the ALMA antenna for a test observation.

The structure of a conserved piezo channel domain reveals a topologically distinct β sandwich fold.

Science.gov (United States)

Kamajaya, Aron; Kaiser, Jens T; Lee, Jonas; Reid, Michelle; Rees, Douglas C

2014-10-07

Piezo has recently been identified as a family of eukaryotic mechanosensitive channels composed of subunits containing over 2,000 amino acids, without recognizable sequence similarity to other channels. Here, we present the crystal structure of a large, conserved extramembrane domain located just before the last predicted transmembrane helix of C. elegans PIEZO, which adopts a topologically distinct β sandwich fold. The structure was also determined of a point mutation located on a conserved surface at the position equivalent to the human PIEZO1 mutation found in dehydrated hereditary stomatocytosis patients (M2225R). While the point mutation does not change the overall domain structure, it does alter the surface electrostatic potential that may perturb interactions with a yet-to-be-identified ligand or protein. The lack of structural similarity between this domain and any previously characterized fold, including those of eukaryotic and bacterial channels, highlights the distinctive nature of the Piezo family of eukaryotic mechanosensitive channels. Copyright © 2014 Elsevier Ltd. All rights reserved.

Easy-to-Build Satellite Beacon Receiver for Propagation Experimentation at Millimeter Bands

Directory of Open Access Journals (Sweden)

F. Machado

2014-04-01

Full Text Available This paper describes the design and development of a digital satellite beacon receiver for propagation experimentation. Satellite beacons are frequently available for pointing large antennas, but such signals can be used for measuring rain attenuation and other phenomena as, for example, tropospheric scintillation. A fairly inexpensive beacon receiver has been built using off-the-shelf parts. This instrument is not at all bulky making it suitable for easy transportation. This article analyzes the receiver specifications, describes in detail its structure and presents some operational test results.

Modulated Magnetic Nanowires for Controlling Domain Wall Motion: Toward 3D Magnetic Memories

KAUST Repository

Ivanov, Yurii P.; Chuvilin, Andrey; Lopatin, Sergei; Kosel, Jü rgen

2016-01-01

Cylindrical magnetic nanowires are attractive materials for next generation data storage devices owing to the theoretically achievable high domain wall velocity and their efficient fabrication in highly dense arrays. In order to obtain control over domain wall motion, reliable and well-defined pinning sites are required. Here, we show that modulated nanowires consisting of alternating nickel and cobalt sections facilitate efficient domain wall pinning at the interfaces of those sections. By combining electron holography with micromagnetic simulations, the pinning effect can be explained by the interaction of the stray fields generated at the interface and the domain wall. Utilizing a modified differential phase contrast imaging, we visualized the pinned domain wall with a high resolution, revealing its three-dimensional vortex structure with the previously predicted Bloch point at its center. These findings suggest the potential of modulated nanowires for the development of high-density, three-dimensional data storage devices. © 2016 American Chemical Society.

A study on group decision-making based fault multi-symptom-domain consensus diagnosis

International Nuclear Information System (INIS)

He Yongyong; Chu Fulei; Zhong Binglin

2001-01-01

In the field of fault diagnosis for rotating machines, the conventional methods or the neural network based methods are mainly single symptom domain based methods, and the diagnosis accuracy of which is not always satisfactory. In this paper, in order to utilize multiple symptom domains to improve the diagnosis accuracy, an idea of fault multi-symptom-domain consensus diagnosis is developed. From the point of view of the group decision-making, two particular multi-symptom-domain diagnosis strategies are proposed. The proposed strategies use BP (Back-Propagation) neural networks as diagnosis models in various symptom domains, and then combine the outputs of these networks by two combination schemes, which are based on Dempster-Shafer evidence theory and fuzzy integral theory, respectively. Finally, a case study pertaining to the fault diagnosis for rotor-bearing systems is given in detail, and the results show that the proposed diagnosis strategies are feasible and more efficient than conventional stacked-vector methods

Modulated Magnetic Nanowires for Controlling Domain Wall Motion: Toward 3D Magnetic Memories

KAUST Repository

Ivanov, Yurii P.

2016-05-03

Cylindrical magnetic nanowires are attractive materials for next generation data storage devices owing to the theoretically achievable high domain wall velocity and their efficient fabrication in highly dense arrays. In order to obtain control over domain wall motion, reliable and well-defined pinning sites are required. Here, we show that modulated nanowires consisting of alternating nickel and cobalt sections facilitate efficient domain wall pinning at the interfaces of those sections. By combining electron holography with micromagnetic simulations, the pinning effect can be explained by the interaction of the stray fields generated at the interface and the domain wall. Utilizing a modified differential phase contrast imaging, we visualized the pinned domain wall with a high resolution, revealing its three-dimensional vortex structure with the previously predicted Bloch point at its center. These findings suggest the potential of modulated nanowires for the development of high-density, three-dimensional data storage devices. © 2016 American Chemical Society.

Safety Culture Assessment Tools in Nuclear and Non-Nuclear Domains

International Nuclear Information System (INIS)

Mkrtchyan, L.; Turcanu, C.

2012-01-01

Over the last decades, in many domains especially in high risk industries, the authorities paid increasing attention to safety management systems and, in particular, to safety culture. Consequently, in the applied and academic literature a huge amount of studies explored the main challenges, issues and obstacles related with safety culture. We undertake a survey of safety culture experiences in the main safety-critical industries such as nuclear, railways, offshore, aviation, airlines, health care, etc. We review both academic and applied literature up to the year 2011. Our results help to establish a comprehensive view on the subject, its main terminologies, existing tools, and main difficulties. The purpose of this report is to raise awareness about the current tools of safety culture assessment, both in the nuclear as well as in the non-nuclear domain. The report provides also practical recommendations about the possible use of each tool given different circumstances and different factors. We do not aim to rank the tools pointing the best one, but we highlight instead the unique features of these tools, pointing their strong and weak sides

Safety Culture Assessment Tools in Nuclear and Non-Nuclear Domains

Energy Technology Data Exchange (ETDEWEB)

Mkrtchyan, L; Turcanu, C

2012-03-15

Over the last decades, in many domains especially in high risk industries, the authorities paid increasing attention to safety management systems and, in particular, to safety culture. Consequently, in the applied and academic literature a huge amount of studies explored the main challenges, issues and obstacles related with safety culture. We undertake a survey of safety culture experiences in the main safety-critical industries such as nuclear, railways, offshore, aviation, airlines, health care, etc. We review both academic and applied literature up to the year 2011. Our results help to establish a comprehensive view on the subject, its main terminologies, existing tools, and main difficulties. The purpose of this report is to raise awareness about the current tools of safety culture assessment, both in the nuclear as well as in the non-nuclear domain. The report provides also practical recommendations about the possible use of each tool given different circumstances and different factors. We do not aim to rank the tools pointing the best one, but we highlight instead the unique features of these tools, pointing their strong and weak sides.

Wall shear stress fixed points in blood flow

Science.gov (United States)

Arzani, Amirhossein; Shadden, Shawn

2017-11-01

Patient-specific computational fluid dynamics produces large datasets, and wall shear stress (WSS) is one of the most important parameters due to its close connection with the biological processes at the wall. While some studies have investigated WSS vectorial features, the WSS fixed points have not received much attention. In this talk, we will discuss the importance of WSS fixed points from three viewpoints. First, we will review how WSS fixed points relate to the flow physics away from the wall. Second, we will discuss how certain types of WSS fixed points lead to high biochemical surface concentration in cardiovascular mass transport problems. Finally, we will introduce a new measure to track the exposure of endothelial cells to WSS fixed points.

The insulin receptor substrate (IRS)-1 pleckstrin homology domain functions in downstream signaling.

Science.gov (United States)

Vainshtein, I; Kovacina, K S; Roth, R A

2001-03-16

The pleckstrin homology (PH) domain of the insulin receptor substrate-1 (IRS-1) plays a role in directing this molecule to the insulin receptor, thereby regulating its tyrosine phosphorylation. In this work, the role of the PH domain in subsequent signaling was studied by constructing constitutively active forms of IRS-1 in which the inter-SH2 domain of the p85 subunit of phosphatidylinositol 3-kinase was fused to portions of the IRS-1 molecule. Chimeric molecules containing the PH domain were found to activate the downstream response of stimulating the Ser/Thr kinase Akt. A chimera containing point mutations in the PH domain that abolished the ability of this domain to bind phosphatidylinositol 4,5-bisphosphate prevented these molecules from activating Akt. These mutations also decreased by about 70% the amount of the constructs present in a particulate fraction of the cells. These results indicate that the PH domain of IRS-1, in addition to directing this protein to the receptor for tyrosine phosphorylation, functions in the ability of this molecule to stimulate subsequent responses. Thus, compromising the function of the PH domain, e.g. in insulin-resistant states, could decrease both the ability of IRS-1 to be tyrosine phosphorylated by the insulin receptor and to link to subsequent downstream targets.

Functional Properties at Domain Walls in BiFeO3: Electrical, Magnetic, and Structural investigations

Science.gov (United States)

He, Qing; Yang, C.-H.; Yu, P.; Gajek, M.; Seidel, J.; Ramesh, R.; Wang, F.; Chu, Y.-H.; Martin, L. W.; Spaldin, N.; Rother, A.

2009-03-01

BiFeO3 (BFO) is a widely studied robust ferroelectric, antiferromagnetic multiferroic. Conducting-atomic force microscopy studies reveal the presence of enhanced conductivity at certain types of domain walls in BFO. We have completed detailed TEM studies of the physical structure at these domain walls as well as in-depth DFT calculations of the evolution of electronic structure at these domain walls. These studies reveal two major contributions to the observed conduction: the formation of an electrostatic potential at the domain walls as well as a structurally-driven change in the electronic structure (i.e., a lower band gap locally) at the domain walls. We will discuss the use of optical characterization techniques as a way of probing this change in electronic structure at domain walls as well as detailed IV characterization both in atmospheric and UHV environments. Finally, the evolution of magnetism at these domain walls has been studied through the use of photoemission measurements. Initial findings point to a significant change in the magnetic order at these domain walls in BFO.

Time Domain Induced Polarization

DEFF Research Database (Denmark)

Fiandaca, Gianluca; Auken, Esben; Christiansen, Anders Vest

2012-01-01

Time-domain-induced polarization has significantly broadened its field of reference during the last decade, from mineral exploration to environmental geophysics, e.g., for clay and peat identification and landfill characterization. Though, insufficient modeling tools have hitherto limited the use...... of time-domaininduced polarization for wider purposes. For these reasons, a new forward code and inversion algorithm have been developed using the full-time decay of the induced polarization response, together with an accurate description of the transmitter waveform and of the receiver transfer function......, to reconstruct the distribution of the Cole-Cole parameters of the earth. The accurate modeling of the transmitter waveform had a strong influence on the forward response, and we showed that the difference between a solution using a step response and a solution using the accurate modeling often is above 100...

Effect of point mutations on Herbaspirillum seropedicae NifA activity

International Nuclear Information System (INIS)

Aquino, B.; Stefanello, A.A.; Oliveira, M.A.S.; Pedrosa, F.O.; Souza, E.M.; Monteiro, R.A.; Chubatsu, L.S.

2015-01-01

NifA is the transcriptional activator of the nif genes in Proteobacteria. It is usually regulated by nitrogen and oxygen, allowing biological nitrogen fixation to occur under appropriate conditions. NifA proteins have a typical three-domain structure, including a regulatory N-terminal GAF domain, which is involved in control by fixed nitrogen and not strictly required for activity, a catalytic AAA+ central domain, which catalyzes open complex formation, and a C-terminal domain involved in DNA-binding. In Herbaspirillum seropedicae, a β-proteobacterium capable of colonizing Graminae of agricultural importance, NifA regulation by ammonium involves its N-terminal GAF domain and the signal transduction protein GlnK. When the GAF domain is removed, the protein can still activate nif genes transcription; however, ammonium regulation is lost. In this work, we generated eight constructs resulting in point mutations in H. seropedicae NifA and analyzed their effect on nifH transcription in Escherichia coli and H. seropedicae. Mutations K22V, T160E, M161V, L172R, and A215D resulted in inactive proteins. Mutations Q216I and S220I produced partially active proteins with activity control similar to wild-type NifA. However, mutation G25E, located in the GAF domain, resulted in an active protein that did not require GlnK for activity and was partially sensitive to ammonium. This suggested that G25E may affect the negative interaction between the N-terminal GAF domain and the catalytic central domain under high ammonium concentrations, thus rendering the protein constitutively active, or that G25E could lead to a conformational change comparable with that when GlnK interacts with the GAF domain

Effect of point mutations on Herbaspirillum seropedicae NifA activity

Directory of Open Access Journals (Sweden)

B. Aquino

2015-08-01

Full Text Available NifA is the transcriptional activator of the nif genes in Proteobacteria. It is usually regulated by nitrogen and oxygen, allowing biological nitrogen fixation to occur under appropriate conditions. NifA proteins have a typical three-domain structure, including a regulatory N-terminal GAF domain, which is involved in control by fixed nitrogen and not strictly required for activity, a catalytic AAA+ central domain, which catalyzes open complex formation, and a C-terminal domain involved in DNA-binding. In Herbaspirillum seropedicae, a β-proteobacterium capable of colonizing Graminae of agricultural importance, NifA regulation by ammonium involves its N-terminal GAF domain and the signal transduction protein GlnK. When the GAF domain is removed, the protein can still activate nif genes transcription; however, ammonium regulation is lost. In this work, we generated eight constructs resulting in point mutations in H. seropedicae NifA and analyzed their effect on nifH transcription in Escherichia coli and H. seropedicae. Mutations K22V, T160E, M161V, L172R, and A215D resulted in inactive proteins. Mutations Q216I and S220I produced partially active proteins with activity control similar to wild-type NifA. However, mutation G25E, located in the GAF domain, resulted in an active protein that did not require GlnK for activity and was partially sensitive to ammonium. This suggested that G25E may affect the negative interaction between the N-terminal GAF domain and the catalytic central domain under high ammonium concentrations, thus rendering the protein constitutively active, or that G25E could lead to a conformational change comparable with that when GlnK interacts with the GAF domain.

Effect of point mutations on Herbaspirillum seropedicae NifA activity.

Science.gov (United States)

Aquino, B; Stefanello, A A; Oliveira, M A S; Pedrosa, F O; Souza, E M; Monteiro, R A; Chubatsu, L S

2015-08-01

NifA is the transcriptional activator of the nif genes in Proteobacteria. It is usually regulated by nitrogen and oxygen, allowing biological nitrogen fixation to occur under appropriate conditions. NifA proteins have a typical three-domain structure, including a regulatory N-terminal GAF domain, which is involved in control by fixed nitrogen and not strictly required for activity, a catalytic AAA+ central domain, which catalyzes open complex formation, and a C-terminal domain involved in DNA-binding. In Herbaspirillum seropedicae, a β-proteobacterium capable of colonizing Graminae of agricultural importance, NifA regulation by ammonium involves its N-terminal GAF domain and the signal transduction protein GlnK. When the GAF domain is removed, the protein can still activate nif genes transcription; however, ammonium regulation is lost. In this work, we generated eight constructs resulting in point mutations in H. seropedicae NifA and analyzed their effect on nifH transcription in Escherichia coli and H. seropedicae. Mutations K22V, T160E, M161V, L172R, and A215D resulted in inactive proteins. Mutations Q216I and S220I produced partially active proteins with activity control similar to wild-type NifA. However, mutation G25E, located in the GAF domain, resulted in an active protein that did not require GlnK for activity and was partially sensitive to ammonium. This suggested that G25E may affect the negative interaction between the N-terminal GAF domain and the catalytic central domain under high ammonium concentrations, thus rendering the protein constitutively active, or that G25E could lead to a conformational change comparable with that when GlnK interacts with the GAF domain.

Effect of point mutations on Herbaspirillum seropedicae NifA activity

Energy Technology Data Exchange (ETDEWEB)

Aquino, B.; Stefanello, A.A.; Oliveira, M.A.S.; Pedrosa, F.O.; Souza, E.M.; Monteiro, R.A.; Chubatsu, L.S. [Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, PR (Brazil)

2015-07-10

NifA is the transcriptional activator of the nif genes in Proteobacteria. It is usually regulated by nitrogen and oxygen, allowing biological nitrogen fixation to occur under appropriate conditions. NifA proteins have a typical three-domain structure, including a regulatory N-terminal GAF domain, which is involved in control by fixed nitrogen and not strictly required for activity, a catalytic AAA+ central domain, which catalyzes open complex formation, and a C-terminal domain involved in DNA-binding. In Herbaspirillum seropedicae, a β-proteobacterium capable of colonizing Graminae of agricultural importance, NifA regulation by ammonium involves its N-terminal GAF domain and the signal transduction protein GlnK. When the GAF domain is removed, the protein can still activate nif genes transcription; however, ammonium regulation is lost. In this work, we generated eight constructs resulting in point mutations in H. seropedicae NifA and analyzed their effect on nifH transcription in Escherichia coli and H. seropedicae. Mutations K22V, T160E, M161V, L172R, and A215D resulted in inactive proteins. Mutations Q216I and S220I produced partially active proteins with activity control similar to wild-type NifA. However, mutation G25E, located in the GAF domain, resulted in an active protein that did not require GlnK for activity and was partially sensitive to ammonium. This suggested that G25E may affect the negative interaction between the N-terminal GAF domain and the catalytic central domain under high ammonium concentrations, thus rendering the protein constitutively active, or that G25E could lead to a conformational change comparable with that when GlnK interacts with the GAF domain.

On a Paneitz type equation in six dimensional domains

Energy Technology Data Exchange (ETDEWEB)

Chtioui, Hichem [Departement de Mathematiques, Faculte des Sciences de Sfax, Route Soukra, Sfax (Tunisia); El Mehdi, Khalil [Faculte des Sciences et Techniques, Universite de Nouakchott, Nouakchott (Morocco); [Abdus Salam International Centre for Theoretical Physics, Trieste (Italy)]. E-mail: khalil@univ-nkc.mr; it, elmehdik@ictp trieste

2003-09-01

In this paper, we consider the equation {delta}{sup 2}u = Ku{sup 5}, u > 0 in {omega}, u = {delta}u = 0 on {partial_derivative}{omega}, where K is a positive function and {omega} is a bounded and smooth domain in R{sup 6}. Using the theory of critical points at infinity, we give some topological conditions on K to ensure some existence results. (author)

Receiver IQ mismatch estimation in PDM CO-OFDM system using training symbol

Science.gov (United States)

Peng, Dandan; Ma, Xiurong; Yao, Xin; Zhang, Haoyuan

2017-07-01

Receiver in-phase/quadrature (IQ) mismatch is hard to mitigate at the receiver via using conventional method in polarization division multiplexed (PDM) coherent optical orthogonal frequency division multiplexing (CO-OFDM) system. In this paper, a novel training symbol structure is proposed to estimate IQ mismatch and channel distortion. Combined this structure with Gram Schmidt orthogonalization procedure (GSOP) algorithm, we can get lower bit error rate (BER). Meanwhile, based on this structure one estimation method is deduced in frequency domain which can achieve the estimation of IQ mismatch and channel distortion independently and improve the system performance obviously. Numerical simulation shows that the proposed two methods have better performance than compared method at 100 Gb/s after 480 km fiber transmission. Besides, the calculation complexity is also analyzed.

Domain Engineering

Science.gov (United States)

Bjørner, Dines

Before software can be designed we must know its requirements. Before requirements can be expressed we must understand the domain. So it follows, from our dogma, that we must first establish precise descriptions of domains; then, from such descriptions, “derive” at least domain and interface requirements; and from those and machine requirements design the software, or, more generally, the computing systems.

Optimal 25-Point Finite-Difference Subgridding Techniques for the 2D Helmholtz Equation

Directory of Open Access Journals (Sweden)

Tingting Wu

2016-01-01

Full Text Available We present an optimal 25-point finite-difference subgridding scheme for solving the 2D Helmholtz equation with perfectly matched layer (PML. This scheme is second order in accuracy and pointwise consistent with the equation. Subgrids are used to discretize the computational domain, including the interior domain and the PML. For the transitional node in the interior domain, the finite difference equation is formulated with ghost nodes, and its weight parameters are chosen by a refined choice strategy based on minimizing the numerical dispersion. Numerical experiments are given to illustrate that the newly proposed schemes can produce highly accurate seismic modeling results with enhanced efficiency.

Collaborative Indoor Access Point Localization Using Autonomous Mobile Robot Swarm

Directory of Open Access Journals (Sweden)

Fahed Awad

2018-01-01

Full Text Available Localization of access points has become an important research problem due to the wide range of applications it addresses such as dismantling critical security threats caused by rogue access points or optimizing wireless coverage of access points within a service area. Existing proposed solutions have mostly relied on theoretical hypotheses or computer simulation to demonstrate the efficiency of their methods. The techniques that rely on estimating the distance using samples of the received signal strength usually assume prior knowledge of the signal propagation characteristics of the indoor environment in hand and tend to take a relatively large number of uniformly distributed random samples. This paper presents an efficient and practical collaborative approach to detect the location of an access point in an indoor environment without any prior knowledge of the environment. The proposed approach comprises a swarm of wirelessly connected mobile robots that collaboratively and autonomously collect a relatively small number of non-uniformly distributed random samples of the access point’s received signal strength. These samples are used to efficiently and accurately estimate the location of the access point. The experimental testing verified that the proposed approach can identify the location of the access point in an accurate and efficient manner.

A two-domain elevator mechanism for sodium/proton antiport.

Science.gov (United States)

Lee, Chiara; Kang, Hae Joo; von Ballmoos, Christoph; Newstead, Simon; Uzdavinys, Povilas; Dotson, David L; Iwata, So; Beckstein, Oliver; Cameron, Alexander D; Drew, David

2013-09-26

Sodium/proton (Na(+)/H(+)) antiporters, located at the plasma membrane in every cell, are vital for cell homeostasis. In humans, their dysfunction has been linked to diseases, such as hypertension, heart failure and epilepsy, and they are well-established drug targets. The best understood model system for Na(+)/H(+) antiport is NhaA from Escherichia coli, for which both electron microscopy and crystal structures are available. NhaA is made up of two distinct domains: a core domain and a dimerization domain. In the NhaA crystal structure a cavity is located between the two domains, providing access to the ion-binding site from the inward-facing surface of the protein. Like many Na(+)/H(+) antiporters, the activity of NhaA is regulated by pH, only becoming active above pH 6.5, at which point a conformational change is thought to occur. The only reported NhaA crystal structure so far is of the low pH inactivated form. Here we describe the active-state structure of a Na(+)/H(+) antiporter, NapA from Thermus thermophilus, at 3 Å resolution, solved from crystals grown at pH 7.8. In the NapA structure, the core and dimerization domains are in different positions to those seen in NhaA, and a negatively charged cavity has now opened to the outside. The extracellular cavity allows access to a strictly conserved aspartate residue thought to coordinate ion binding directly, a role supported here by molecular dynamics simulations. To alternate access to this ion-binding site, however, requires a surprisingly large rotation of the core domain, some 20° against the dimerization interface. We conclude that despite their fast transport rates of up to 1,500 ions per second, Na(+)/H(+) antiporters operate by a two-domain rocking bundle model, revealing themes relevant to secondary-active transporters in general.

Power Absorption by Closely Spaced Point Absorbers in Constrained Conditions

DEFF Research Database (Denmark)

De Backer, G.; Vantorre, M.; Beels, C.

2010-01-01

The performance of an array of closely spaced point absorbers is numerically assessed in a frequency domain model Each point absorber is restricted to the heave mode and is assumed to have its own linear power take-off (PTO) system Unidirectional irregular incident waves are considered......, representing the wave climate at Westhinder on the Belgian Continental Shelf The impact of slamming, stroke and force restrictions on the power absorption is evaluated and optimal PTO parameters are determined For multiple bodies optimal control parameters (CP) are not only dependent on the incoming waves...

Testing for Granger Causality in the Frequency Domain: A Phase Resampling Method.

Science.gov (United States)

Liu, Siwei; Molenaar, Peter

2016-01-01

This article introduces phase resampling, an existing but rarely used surrogate data method for making statistical inferences of Granger causality in frequency domain time series analysis. Granger causality testing is essential for establishing causal relations among variables in multivariate dynamic processes. However, testing for Granger causality in the frequency domain is challenging due to the nonlinear relation between frequency domain measures (e.g., partial directed coherence, generalized partial directed coherence) and time domain data. Through a simulation study, we demonstrate that phase resampling is a general and robust method for making statistical inferences even with short time series. With Gaussian data, phase resampling yields satisfactory type I and type II error rates in all but one condition we examine: when a small effect size is combined with an insufficient number of data points. Violations of normality lead to slightly higher error rates but are mostly within acceptable ranges. We illustrate the utility of phase resampling with two empirical examples involving multivariate electroencephalography (EEG) and skin conductance data.

Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.

Directory of Open Access Journals (Sweden)

Jorge Fernández-Trillo

Full Text Available A conserved eag domain in the cytoplasmic amino terminus of the human ether-a-go-go-related gene (hERG potassium channel is critical for its slow deactivation gating. Introduction of gene fragments encoding the eag domain are able to restore normal deactivation properties of channels from which most of the amino terminus has been deleted, and also those lacking exclusively the eag domain or carrying a single point mutation in the initial residues of the N-terminus. Deactivation slowing in the presence of the recombinant domain is not observed with channels carrying a specific Y542C point mutation in the S4-S5 linker. On the other hand, mutations in some initial positions of the recombinant fragment also impair its ability to restore normal deactivation. Fluorescence resonance energy transfer (FRET analysis of fluorophore-tagged proteins under total internal reflection fluorescence (TIRF conditions revealed a substantial level of FRET between the introduced N-terminal eag fragments and the eag domain-deleted channels expressed at the membrane, but not between the recombinant eag domain and full-length channels with an intact amino terminus. The FRET signals were also minimized when the recombinant eag fragments carried single point mutations in the initial portion of their amino end, and when Y542C mutated channels were used. These data suggest that the restoration of normal deactivation gating by the N-terminal recombinant eag fragment is an intrinsic effect of this domain directed by the interaction of its N-terminal segment with the gating machinery, likely at the level of the S4-S5 linker.

Dental optical coherence domain reflectometry explorer

Energy Technology Data Exchange (ETDEWEB)

Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Pleasanton, CA)

2001-01-01

A hand-held, fiber optic based dental device with optical coherence domain reflectometry (OCDR) sensing capabilities provides a profile of optical scattering as a function of depth in the tissue at the point where the tip of the dental explorer touches the tissue. This system provides information on the internal structure of the dental tissue, which is then used to detect caries and periodontal disease. A series of profiles of optical scattering or tissue microstructure are generated by moving the explorer across the tooth or other tissue. The profiles are combined to form a cross-sectional, or optical coherence tomography (OCT), image.

High-resolution wave number spectrum using multi-point measurements in space – the Multi-point Signal Resonator (MSR technique

Directory of Open Access Journals (Sweden)

Y. Narita

2011-02-01

Full Text Available A new analysis method is presented that provides a high-resolution power spectrum in a broad wave number domain based on multi-point measurements. The analysis technique is referred to as the Multi-point Signal Resonator (MSR and it benefits from Capon's minimum variance method for obtaining the proper power spectral density of the signal as well as the MUSIC algorithm (Multiple Signal Classification for considerably reducing the noise part in the spectrum. The mathematical foundation of the analysis method is presented and it is applied to synthetic data as well as Cluster observations of the interplanetary magnetic field. Using the MSR technique for Cluster data we find a wave in the solar wind propagating parallel to the mean magnetic field with relatively small amplitude, which is not identified by the Capon spectrum. The Cluster data analysis shows the potential of the MSR technique for studying waves and turbulence using multi-point measurements.

Irregular Homogeneity Domains in Ternary Intermetallic Systems

Directory of Open Access Journals (Sweden)

Jean-Marc Joubert

2015-12-01

Full Text Available Ternary intermetallic A–B–C systems sometimes have unexpected behaviors. The present paper examines situations in which there is a tendency to simultaneously form the compounds ABx, ACx and BCx with the same crystal structure. This causes irregular shapes of the phase homogeneity domains and, from a structural point of view, a complete reversal of site occupancies for the B atom when crossing the homogeneity domain. This work reviews previous studies done in the systems Fe–Nb–Zr, Hf–Mo–Re, Hf–Re–W, Mo–Re–Zr, Re–W–Zr, Cr–Mn–Si, Cr–Mo–Re, and Mo–Ni–Re, and involving the topologically close-packed Laves, χ and σ phases. These systems have been studied using ternary isothermal section determination, DFT calculations, site occupancy measurement using joint X-ray, and neutron diffraction Rietveld refinement. Conclusions are drawn concerning this phenomenon. The paper also reports new experimental or calculated data on Co–Cr–Re and Fe–Nb–Zr systems.

Spatial and frequency domain ring source models for the single muscle fiber action potential

DEFF Research Database (Denmark)

Henneberg, Kaj-åge; R., Plonsey

1994-01-01

In the paper, single-fibre models for the extracellular action potential are developed that will allow the potential to the evaluated at an arbitrary field point in the extracellular space. Fourier-domain models are restricted in that they evaluate potentials at equidistant points along a line...... parallel to the fibre axis. Consequently, they cannot easily evaluate the potential at the boundary nodes of a boundary-element electrode model. The Fourier-domain models employ axial-symmetric ring source models, and thereby provide higher accuracy that the line source model, where the source is lumped...... including anisotropy show that the spatial models require extreme care in the integration procedure owing to the singularity in the weighting functions. With adequate sampling, the spatial models can evaluate extracellular potentials with high accuracy....

Domain decomposition method for solving elliptic problems in unbounded domains

International Nuclear Information System (INIS)

Khoromskij, B.N.; Mazurkevich, G.E.; Zhidkov, E.P.

1991-01-01

Computational aspects of the box domain decomposition (DD) method for solving boundary value problems in an unbounded domain are discussed. A new variant of the DD-method for elliptic problems in unbounded domains is suggested. It is based on the partitioning of an unbounded domain adapted to the given asymptotic decay of an unknown function at infinity. The comparison of computational expenditures is given for boundary integral method and the suggested DD-algorithm. 29 refs.; 2 figs.; 2 tabs

Assessment of Quality of Life of HIV-Positive People Receiving ART: An Indian Perspective.

Science.gov (United States)

Anand, Deepika; Puri, Seema; Mathew, Minnie

2012-07-01

HIV/AIDS is known to affect an individual not only physically but also mentally, socially, and financially. It is a syndrome that builds a vacuum in a person affecting his/her life as a whole. The purpose of the present study is to evaluate the quality of life (QOL) of people living with HIV/AIDS (PLHIV) receiving ART and its association with Body mass index (BMI) and CD4 count. An observational study was performed on PLHIV receiving ART in Orissa, India. Data on sociodemographic profile, BMI, and CD4 were gathered from 153 HIV-positive subjects. QOL was assessed using WHOQOL-HIV BREF scale. The overall QOL score of the subjects was moderate; PLHIV with lower BMI also had poorer QOL (P<0.05). Employment affected only the social health domain of the subjects. Men reported poorer level of independence and physical health while women reported poorer social relationships and environment. All the six domains correlated significantly with the overall QOL indicated by the G-facet. Attention toward improving the nutritional status of PLHIV should be accorded high priority to ensure improvement in the overall QOL of PLHIV.

The SHOCT domain: a widespread domain under-represented in model organisms.

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Ruth Y Eberhardt

Full Text Available We have identified a new protein domain, which we have named the SHOCT domain (Short C-terminal domain. This domain is widespread in bacteria with over a thousand examples. But we found it is missing from the most commonly studied model organisms, despite being present in closely related species. It's predominantly C-terminal location, co-occurrence with numerous other domains and short size is reminiscent of the Gram-positive anchor motif, however it is present in a much wider range of species. We suggest several hypotheses about the function of SHOCT, including oligomerisation and nucleic acid binding. Our initial experiments do not support its role as an oligomerisation domain.

Domain-to-domain coupling in voltage-sensing phosphatase.

Science.gov (United States)

Sakata, Souhei; Matsuda, Makoto; Kawanabe, Akira; Okamura, Yasushi

2017-01-01

Voltage-sensing phosphatase (VSP) consists of a transmembrane voltage sensor and a cytoplasmic enzyme region. The enzyme region contains the phosphatase and C2 domains, is structurally similar to the tumor suppressor phosphatase PTEN, and catalyzes the dephosphorylation of phosphoinositides. The transmembrane voltage sensor is connected to the phosphatase through a short linker region, and phosphatase activity is induced upon membrane depolarization. Although the detailed molecular characteristics of the voltage sensor domain and the enzyme region have been revealed, little is known how these two regions are coupled. In addition, it is important to know whether mechanism for coupling between the voltage sensor domain and downstream effector function is shared among other voltage sensor domain-containing proteins. Recent studies in which specific amino acid sites were genetically labeled using a fluorescent unnatural amino acid have enabled detection of the local structural changes in the cytoplasmic region of Ciona intestinalis VSP that occur with a change in membrane potential. The results of those studies provide novel insight into how the enzyme activity of the cytoplasmic region of VSP is regulated by the voltage sensor domain.

Stepwise withdrawal of inhaled corticosteroids in COPD patients receiving dual bronchodilation

DEFF Research Database (Denmark)

Magnussen, Helgo; Watz, Henrik; Kirsten, Anne

2014-01-01

-controlled fashion, one group of patients continues to receive tiotropium, salmeterol and fluticasone, while the second group initiates stepwise withdrawal of fluticasone. The primary end point is time to first moderate or severe exacerbation following randomized treatment over 52 weeks. Lung function, symptoms...

Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope-integrated spectral domain optical coherence tomography device.

Science.gov (United States)

Hahn, Paul; Migacz, Justin; O'Donnell, Rachelle; Day, Shelley; Lee, Annie; Lin, Phoebe; Vann, Robin; Kuo, Anthony; Fekrat, Sharon; Mruthyunjaya, Prithvi; Postel, Eric A; Izatt, Joseph A; Toth, Cynthia A

2013-01-01

The authors have recently developed a high-resolution microscope-integrated spectral domain optical coherence tomography (MIOCT) device designed to enable OCT acquisition simultaneous with surgical maneuvers. The purpose of this report is to describe translation of this device from preclinical testing into human intraoperative imaging. Before human imaging, surgical conditions were fully simulated for extensive preclinical MIOCT evaluation in a custom model eye system. Microscope-integrated spectral domain OCT images were then acquired in normal human volunteers and during vitreoretinal surgery in patients who consented to participate in a prospective institutional review board-approved study. Microscope-integrated spectral domain OCT images were obtained before and at pauses in surgical maneuvers and were compared based on predetermined diagnostic criteria to images obtained with a high-resolution spectral domain research handheld OCT system (HHOCT; Bioptigen, Inc) at the same time point. Cohorts of five consecutive patients were imaged. Successful end points were predefined, including ≥80% correlation in identification of pathology between MIOCT and HHOCT in ≥80% of the patients. Microscope-integrated spectral domain OCT was favorably evaluated by study surgeons and scrub nurses, all of whom responded that they would consider participating in human intraoperative imaging trials. The preclinical evaluation identified significant improvements that were made before MIOCT use during human surgery. The MIOCT transition into clinical human research was smooth. Microscope-integrated spectral domain OCT imaging in normal human volunteers demonstrated high resolution comparable to tabletop scanners. In the operating room, after an initial learning curve, surgeons successfully acquired human macular MIOCT images before and after surgical maneuvers. Microscope-integrated spectral domain OCT imaging confirmed preoperative diagnoses, such as full-thickness macular hole

MIT domain of Vps4 is a Ca2+-dependent phosphoinositide-binding domain.

Science.gov (United States)

Iwaya, Naoko; Takasu, Hirotoshi; Goda, Natsuko; Shirakawa, Masahiro; Tanaka, Toshiki; Hamada, Daizo; Hiroaki, Hidekazu

2013-05-01

The microtubule interacting and trafficking (MIT) domain is a small protein module that is conserved in proteins of diverged function, such as Vps4, spastin and sorting nexin 15 (SNX15). The molecular function of the MIT domain is protein-protein interaction, in which the domain recognizes peptides containing MIT-interacting motifs. Recently, we identified an evolutionarily related domain, 'variant' MIT domain at the N-terminal region of the microtubule severing enzyme katanin p60. We found that the domain was responsible for binding to microtubules and Ca(2+). Here, we have examined whether the authentic MIT domains also bind Ca(2+). We found that the loop between the first and second α-helices of the MIT domain binds a Ca(2+) ion. Furthermore, the MIT domains derived from Vps4b and SNX15a showed phosphoinositide-binding activities in a Ca(2+)-dependent manner. We propose that the MIT domain is a novel membrane-associating domain involved in endosomal trafficking.

A structural role for the PHP domain in E. coli DNA polymerase III.

Science.gov (United States)

Barros, Tiago; Guenther, Joel; Kelch, Brian; Anaya, Jordan; Prabhakar, Arjun; O'Donnell, Mike; Kuriyan, John; Lamers, Meindert H

2013-05-14

In addition to the core catalytic machinery, bacterial replicative DNA polymerases contain a Polymerase and Histidinol Phosphatase (PHP) domain whose function is not entirely understood. The PHP domains of some bacterial replicases are active metal-dependent nucleases that may play a role in proofreading. In E. coli DNA polymerase III, however, the PHP domain has lost several metal-coordinating residues and is likely to be catalytically inactive. Genomic searches show that the loss of metal-coordinating residues in polymerase PHP domains is likely to have coevolved with the presence of a separate proofreading exonuclease that works with the polymerase. Although the E. coli Pol III PHP domain has lost metal-coordinating residues, the structure of the domain has been conserved to a remarkable degree when compared to that of metal-binding PHP domains. This is demonstrated by our ability to restore metal binding with only three point mutations, as confirmed by the metal-bound crystal structure of this mutant determined at 2.9 Å resolution. We also show that Pol III, a large multi-domain protein, unfolds cooperatively and that mutations in the degenerate metal-binding site of the PHP domain decrease the overall stability of Pol III and reduce its activity. While the presence of a PHP domain in replicative bacterial polymerases is strictly conserved, its ability to coordinate metals and to perform proofreading exonuclease activity is not, suggesting additional non-enzymatic roles for the domain. Our results show that the PHP domain is a major structural element in Pol III and its integrity modulates both the stability and activity of the polymerase.

Radon-domain interferometric interpolation for reconstruction of the near-offset gap in marine seismic data

Science.gov (United States)

Xu, Zhuo; Sopher, Daniel; Juhlin, Christopher; Han, Liguo; Gong, Xiangbo

2018-04-01

In towed marine seismic data acquisition, a gap between the source and the nearest recording channel is typical. Therefore, extrapolation of the missing near-offset traces is often required to avoid unwanted effects in subsequent data processing steps. However, most existing interpolation methods perform poorly when extrapolating traces. Interferometric interpolation methods are one particular method that have been developed for filling in trace gaps in shot gathers. Interferometry-type interpolation methods differ from conventional interpolation methods as they utilize information from several adjacent shot records to fill in the missing traces. In this study, we aim to improve upon the results generated by conventional time-space domain interferometric interpolation by performing interferometric interpolation in the Radon domain, in order to overcome the effects of irregular data sampling and limited source-receiver aperture. We apply both time-space and Radon-domain interferometric interpolation methods to the Sigsbee2B synthetic dataset and a real towed marine dataset from the Baltic Sea with the primary aim to improve the image of the seabed through extrapolation into the near-offset gap. Radon-domain interferometric interpolation performs better at interpolating the missing near-offset traces than conventional interferometric interpolation when applied to data with irregular geometry and limited source-receiver aperture. We also compare the interferometric interpolated results with those obtained using solely Radon transform (RT) based interpolation and show that interferometry-type interpolation performs better than solely RT-based interpolation when extrapolating the missing near-offset traces. After data processing, we show that the image of the seabed is improved by performing interferometry-type interpolation, especially when Radon-domain interferometric interpolation is applied.

Transforming knowledge across domains in the temporary development spaces

DEFF Research Database (Denmark)

Brønnum, Louise

This paper addresses transformation of knowledge across different knowledge domains and competencies in the Front End of Innovation (FEI) [Koen 2002].We examine the temporary spaces [Clausen, Yoshinaka 2007] that emerge when different knowledge domains are brought into play (implicit or explicit......) in staging innovative concept development. FEI appears as temporary spaces for innovative processes; and studies have pointed out the limited uptake of user knowledge (Elgaard Jensen 2012). This paper will discuss the possibilities and barriers for uptake of user knowledge in FEI in relation...... to the constitutions of these temporary spaces. There seems to be a limited understanding of: how knowledge is transferred and transformed into design objects facilitating a process where knowledge enables innovative thinking across knowledge boundaries. The paper is based on empirical data primarily from case studies...

Infrared images target detection based on background modeling in the discrete cosine domain

Science.gov (United States)

Ye, Han; Pei, Jihong

2018-02-01

Background modeling is the critical technology to detect the moving target for video surveillance. Most background modeling techniques are aimed at land monitoring and operated in the spatial domain. A background establishment becomes difficult when the scene is a complex fluctuating sea surface. In this paper, the background stability and separability between target are analyzed deeply in the discrete cosine transform (DCT) domain, on this basis, we propose a background modeling method. The proposed method models each frequency point as a single Gaussian model to represent background, and the target is extracted by suppressing the background coefficients. Experimental results show that our approach can establish an accurate background model for seawater, and the detection results outperform other background modeling methods in the spatial domain.

Eigenvectors and fixed point of non-linear operators

Directory of Open Access Journals (Sweden)

Giulio Trombetta

2007-12-01

Full Text Available Let X be a real infinite-dimensional Banach space and ψ a measure of noncompactness on X. Let Ω be a bounded open subset of X and A : Ω → X a ψ-condensing operator, which has no fixed points on ∂Ω.Then the fixed point index, ind(A,Ω, of A on Ω is defined (see, for example, ([1] and [18]. In particular, if A is a compact operator ind(A,Ω agrees with the classical Leray-Schauder degree of I −A on Ω relative to the point 0, deg(I −A,Ω,0. The main aim of this note is to investigate boundary conditions, under which the fixed point index of strict- ψ-contractive or ψ-condensing operators A : Ω → X is equal to zero. Correspondingly, results on eigenvectors and nonzero fixed points of k-ψ-contractive and ψ-condensing operators are obtained. In particular we generalize the Birkhoff-Kellog theorem [4] and Guo’s domain compression and expansion theorem [17]. The note is based mainly on the results contained in [7] and [8].

Algorithm for determining two-periodic steady-states in AC machines directly in time domain

Directory of Open Access Journals (Sweden)

Sobczyk Tadeusz J.

2016-09-01

Full Text Available This paper describes an algorithm for finding steady states in AC machines for the cases of their two-periodic nature. The algorithm enables to specify the steady-state solution identified directly in time domain despite of the fact that two-periodic waveforms are not repeated in any finite time interval. The basis for such an algorithm is a discrete differential operator that specifies the temporary values of the derivative of the two-periodic function in the selected set of points on the basis of the values of that function in the same set of points. It allows to develop algebraic equations defining the steady state solution reached in a chosen point set for the nonlinear differential equations describing the AC machines when electrical and mechanical equations should be solved together. That set of those values allows determining the steady state solution at any time instant up to infinity. The algorithm described in this paper is competitive with respect to the one known in literature an approach based on the harmonic balance method operated in frequency domain.

Mechanical design of the third FnIII domain of tenascin-C.

Science.gov (United States)

Peng, Qing; Zhuang, Shulin; Wang, Meijia; Cao, Yi; Khor, Yuanai; Li, Hongbin

2009-03-13

By combining single-molecule atomic force microscopy (AFM), proline mutagenesis and steered molecular dynamics (SMD) simulations, we investigated the mechanical unfolding dynamics and mechanical design of the third fibronectin type III domain of tenascin-C (TNfn3) in detail. We found that the mechanical stability of TNfn3 is similar to that of other constituting FnIII domains of tenascin-C, and the unfolding process of TNfn3 is an apparent two-state process. By employing proline mutagenesis to block the formation of backbone hydrogen bonds and introduce structural disruption in beta sheet, we revealed that in addition to the important roles played by hydrophobic core packing, backbone hydrogen bonds in beta hairpins are also responsible for the overall mechanical stability of TNfn3. Furthermore, proline mutagenesis revealed that the mechanical design of TNfn3 is robust and the mechanical stability of TNfn3 is very resistant to structural disruptions caused by proline substitutions in beta sheets. Proline mutant F88P is one exception, as the proline mutation at position 88 reduced the mechanical stability of TNfn3 significantly and led to unfolding forces of < 20 pN. This result suggests that Phe88 is a weak point of the mechanical resistance for TNfn3. We used SMD simulations to understand the molecular details underlying the mechanical unfolding of TNfn3. The comparison between the AFM results and SMD simulations revealed similarities and discrepancies between the two. We compared the mechanical unfolding and design of TNfn3 and its structural homologue, the tenth FnIII domain from fibronectin. These results revealed the complexity underlying the mechanical design of FnIII domains and will serve as a starting point for systematically analyzing the mechanical architecture of other FnIII domains in tenascins-C, and will help to gain a better understanding of some of the complex features observed for the stretching of native tenascin-C.

Quality of life assessment in dogs and cats receiving chemotherapy

DEFF Research Database (Denmark)

Vøls, Kåre Kryger; Heden, Martin Anker; Kristensen, Annemarie Thuri

2017-01-01

This study aimed to review currently reported methods of assessing the effects of chemotherapy on the quality of life (QoL) of canine and feline patients and to explore novel ways to assess QoL in such patients in the light of the experience to date in human pediatric oncology. A qualitative comp...... of potentially relevant parameters in future QoL assessments may benefit owner decision making....... to assess QoL in toddlers. Each of the identified publications including QoL-assessment in dogs and cats receiving chemotherapy applied a different method of QoL-assessment. In addition, the veterinary QoL-assessments were mainly focused on physical clinical parameters, whereas the emotional (6/11), social...... (4/11) and role (4/11) domains were less represented. QoL-assessment of cats and dogs receiving chemotherapy is in its infancy. The most commonly reported method to assess QoL was questionnaire based and mostly included physical and clinical parameters. Standardizing and including a complete range...

Conversion of Dielectric Data from the Time Domain to the Frequency Domain

Directory of Open Access Journals (Sweden)

Vladimir Durman

2005-01-01

Full Text Available Polarisation and conduction processes in dielectric systems can be identified by the time domain or the frequency domain measurements. If the systems is a linear one, the results of the time domain measurements can be transformed into the frequency domain, and vice versa. Commonly, the time domain data of the absorption conductivity are transformed into the frequency domain data of the dielectric susceptibility. In practice, the relaxation are mainly evaluated by the frequency domain data. In the time domain, the absorption current measurement were prefered up to now. Recent methods are based on the recovery voltage measurements. In this paper a new method of the recovery data conversion from the time the frequency domain is proposed. The method is based on the analysis of the recovery voltage transient based on the Maxwell equation for the current density in a dielectric. Unlike the previous published solutions, the Laplace fransform was used to derive a formula suitable for practical purposes. the proposed procedure allows also calculating of the insulation resistance and separating the polarisation and conduction losses.

Predicting detection performance with model observers: Fourier domain or spatial domain?

Science.gov (United States)

Chen, Baiyu; Yu, Lifeng; Leng, Shuai; Kofler, James; Favazza, Christopher; Vrieze, Thomas; McCollough, Cynthia

2016-02-27

The use of Fourier domain model observer is challenged by iterative reconstruction (IR), because IR algorithms are nonlinear and IR images have noise texture different from that of FBP. A modified Fourier domain model observer, which incorporates nonlinear noise and resolution properties, has been proposed for IR and needs to be validated with human detection performance. On the other hand, the spatial domain model observer is theoretically applicable to IR, but more computationally intensive than the Fourier domain method. The purpose of this study is to compare the modified Fourier domain model observer to the spatial domain model observer with both FBP and IR images, using human detection performance as the gold standard. A phantom with inserts of various low contrast levels and sizes was repeatedly scanned 100 times on a third-generation, dual-source CT scanner at 5 dose levels and reconstructed using FBP and IR algorithms. The human detection performance of the inserts was measured via a 2-alternative-forced-choice (2AFC) test. In addition, two model observer performances were calculated, including a Fourier domain non-prewhitening model observer and a spatial domain channelized Hotelling observer. The performance of these two mode observers was compared in terms of how well they correlated with human observer performance. Our results demonstrated that the spatial domain model observer correlated well with human observers across various dose levels, object contrast levels, and object sizes. The Fourier domain observer correlated well with human observers using FBP images, but overestimated the detection performance using IR images.

Laplace-Fourier-domain dispersion analysis of an average derivative optimal scheme for scalar-wave equation

Science.gov (United States)

Chen, Jing-Bo

2014-06-01

By using low-frequency components of the damped wavefield, Laplace-Fourier-domain full waveform inversion (FWI) can recover a long-wavelength velocity model from the original undamped seismic data lacking low-frequency information. Laplace-Fourier-domain modelling is an important foundation of Laplace-Fourier-domain FWI. Based on the numerical phase velocity and the numerical attenuation propagation velocity, a method for performing Laplace-Fourier-domain numerical dispersion analysis is developed in this paper. This method is applied to an average-derivative optimal scheme. The results show that within the relative error of 1 per cent, the Laplace-Fourier-domain average-derivative optimal scheme requires seven gridpoints per smallest wavelength and smallest pseudo-wavelength for both equal and unequal directional sampling intervals. In contrast, the classical five-point scheme requires 23 gridpoints per smallest wavelength and smallest pseudo-wavelength to achieve the same accuracy. Numerical experiments demonstrate the theoretical analysis.

Evaluation of null-point detection methods on simulation data

Science.gov (United States)

Olshevsky, Vyacheslav; Fu, Huishan; Vaivads, Andris; Khotyaintsev, Yuri; Lapenta, Giovanni; Markidis, Stefano

2014-05-01

We model the measurements of artificial spacecraft that resemble the configuration of CLUSTER propagating in the particle-in-cell simulation of turbulent magnetic reconnection. The simulation domain contains multiple isolated X-type null-points, but the majority are O-type null-points. Simulations show that current pinches surrounded by twisted fields, analogous to laboratory pinches, are formed along the sequences of O-type nulls. In the simulation, the magnetic reconnection is mainly driven by the kinking of the pinches, at spatial scales of several ion inertial lentghs. We compute the locations of magnetic null-points and detect their type. When the satellites are separated by the fractions of ion inertial length, as it is for CLUSTER, they are able to locate both the isolated null-points, and the pinches. We apply the method to the real CLUSTER data and speculate how common are pinches in the magnetosphere, and whether they play a dominant role in the dissipation of magnetic energy.

Development of a point-kinetic verification scheme for nuclear reactor applications

Energy Technology Data Exchange (ETDEWEB)

Demazière, C., E-mail: demaz@chalmers.se; Dykin, V.; Jareteg, K.

2017-06-15

In this paper, a new method that can be used for checking the proper implementation of time- or frequency-dependent neutron transport models and for verifying their ability to recover some basic reactor physics properties is proposed. This method makes use of the application of a stationary perturbation to the system at a given frequency and extraction of the point-kinetic component of the system response. Even for strongly heterogeneous systems for which an analytical solution does not exist, the point-kinetic component follows, as a function of frequency, a simple analytical form. The comparison between the extracted point-kinetic component and its expected analytical form provides an opportunity to verify and validate neutron transport solvers. The proposed method is tested on two diffusion-based codes, one working in the time domain and the other working in the frequency domain. As long as the applied perturbation has a non-zero reactivity effect, it is demonstrated that the method can be successfully applied to verify and validate time- or frequency-dependent neutron transport solvers. Although the method is demonstrated in the present paper in a diffusion theory framework, higher order neutron transport methods could be verified based on the same principles.

The use of ZFP lossy floating point data compression in tornado-resolving thunderstorm simulations

Science.gov (United States)

Orf, L.

2017-12-01

In the field of atmospheric science, numerical models are used to produce forecasts of weather and climate and serve as virtual laboratories for scientists studying atmospheric phenomena. In both operational and research arenas, atmospheric simulations exploiting modern supercomputing hardware can produce a tremendous amount of data. During model execution, the transfer of floating point data from memory to the file system is often a significant bottleneck where I/O can dominate wallclock time. One way to reduce the I/O footprint is to compress the floating point data, which reduces amount of data saved to the file system. In this presentation we introduce LOFS, a file system developed specifically for use in three-dimensional numerical weather models that are run on massively parallel supercomputers. LOFS utilizes the core (in-memory buffered) HDF5 driver and includes compression options including ZFP, a lossy floating point data compression algorithm. ZFP offers several mechanisms for specifying the amount of lossy compression to be applied to floating point data, including the ability to specify the maximum absolute error allowed in each compressed 3D array. We explore different maximum error tolerances in a tornado-resolving supercell thunderstorm simulation for model variables including cloud and precipitation, temperature, wind velocity and vorticity magnitude. We find that average compression ratios exceeding 20:1 in scientifically interesting regions of the simulation domain produce visually identical results to uncompressed data in visualizations and plots. Since LOFS splits the model domain across many files, compression ratios for a given error tolerance can be compared across different locations within the model domain. We find that regions of high spatial variability (which tend to be where scientifically interesting things are occurring) show the lowest compression ratios, whereas regions of the domain with little spatial variability compress

Genetic and Non-genetic Factors Associated WithConstipation in Cancer Patients Receiving Opioids

OpenAIRE

Laugsand, Eivor Alette; Skorpen, Frank; Kaasa, Stein; Sabatowski, Rainer; Strasser, Florian; Fayers, Peter; Klepstad, Pål

2015-01-01

Objectives: To examine whether the inter-individual variation in constipation among patients receiving opioids for cancer pain is associated with genetic or non-genetic factors. Methods: Cancer patients receiving opioids were included from 17 centers in 11 European countries. Intensity of constipation was reported by 1,568 patients on a four-point categorical scale. Non-genetic factors were included as covariates in stratified regression analyses on the association between constipation a...

A Cartesian Grid Embedded Boundary Method for Poisson's Equation on Irregular Domains

Science.gov (United States)

Johansen, Hans; Colella, Phillip

1998-11-01

We present a numerical method for solving Poisson's equation, with variable coefficients and Dirichlet boundary conditions, on two-dimensional regions. The approach uses a finite-volume discretization, which embeds the domain in a regular Cartesian grid. We treat the solution as a cell-centered quantity, even when those centers are outside the domain. Cells that contain a portion of the domain boundary use conservative differencing of second-order accurate fluxes on each cell volume. The calculation of the boundary flux ensures that the conditioning of the matrix is relatively unaffected by small cell volumes. This allows us to use multigrid iterations with a simple point relaxation strategy. We have combined this with an adaptive mesh refinement (AMR) procedure. We provide evidence that the algorithm is second-order accurate on various exact solutions and compare the adaptive and nonadaptive calculations.

Probing SH2-domains using Inhibitor Affinity Purification (IAP).

Science.gov (United States)

Höfener, Michael; Heinzlmeir, Stephanie; Kuster, Bernhard; Sewald, Norbert

2014-01-01

Many human diseases are correlated with the dysregulation of signal transduction processes. One of the most important protein interaction domains in the context of signal transduction is the Src homology 2 (SH2) domain that binds phosphotyrosine residues. Hence, appropriate methods for the investigation of SH2 proteins are indispensable in diagnostics and medicinal chemistry. Therefore, an affinity resin for the enrichment of all SH2 proteins in one experiment would be desirable. However, current methods are unable to address all SH2 proteins simultaneously with a single compound or a small array of compounds. In order to overcome these limitations for the investigation of this particular protein family in future experiments, a dipeptide-derived probe has been designed, synthesized and evaluated. This probe successfully enriched 22 SH2 proteins from mixed cell lysates which contained 50 SH2 proteins. Further characterization of the SH2 binding properties of the probe using depletion and competition experiments indicated its ability to enrich complexes consisting of SH2 domain bearing regulatory PI3K subunits and catalytic phosphoinositide 3-kinase (PI3K) subunits that have no SH2 domain. The results make this probe a promising starting point for the development of a mixed affinity resin with complete SH2 protein coverage. Moreover, the additional findings render it a valuable tool for the evaluation of PI3K complex interrupting inhibitors.

ASH structure alignment package: Sensitivity and selectivity in domain classification

Directory of Open Access Journals (Sweden)

Toh Hiroyuki

2007-04-01

Full Text Available Abstract Background Structure alignment methods offer the possibility of measuring distant evolutionary relationships between proteins that are not visible by sequence-based analysis. However, the question of how structural differences and similarities ought to be quantified in this regard remains open. In this study we construct a training set of sequence-unique CATH and SCOP domains, from which we develop a scoring function that can reliably identify domains with the same CATH topology and SCOP fold classification. The score is implemented in the ASH structure alignment package, for which the source code and a web service are freely available from the PDBj website http://www.pdbj.org/ASH/. Results The new ASH score shows increased selectivity and sensitivity compared with values reported for several popular programs using the same test set of 4,298,905 structure pairs, yielding an area of .96 under the receiver operating characteristic (ROC curve. In addition, weak sequence homologies between similar domains are revealed that could not be detected by BLAST sequence alignment. Also, a subset of domain pairs is identified that exhibit high similarity, even though their CATH and SCOP classification differs. Finally, we show that the ranking of alignment programs based solely on geometric measures depends on the choice of the quality measure. Conclusion ASH shows high selectivity and sensitivity with regard to domain classification, an important step in defining distantly related protein sequence families. Moreover, the CPU cost per alignment is competitive with the fastest programs, making ASH a practical option for large-scale structure classification studies.

Concrete domains

OpenAIRE

Kahn, G.; Plotkin, G.D.

1993-01-01

This paper introduces the theory of a particular kind of computation domains called concrete domains. The purpose of this theory is to find a satisfactory framework for the notions of coroutine computation and sequentiality of evaluation.

A Logic for Inclusion of Administrative Domains and Administrators in Multi-domain Authorization

Science.gov (United States)

Iranmanesh, Zeinab; Amini, Morteza; Jalili, Rasool

Authorization policies for an administrative domain or a composition of multiple domains in multi-domain environments are determined by either one administrator or multiple administrators' cooperation. Several logic-based models for multi-domain environments' authorization have been proposed; however, they have not considered administrators and administrative domains in policies' representation. In this paper, we propose the syntax, proof theory, and semantics of a logic for multi-domain authorization policies including administrators and administrative domains. Considering administrators in policies provides the possibility of presenting composite administration having applicability in many collaborative applications. Indeed, administrators and administrative domains stated in policies can be used in authorization. The presented logic is based on modal logic and utilizes two calculi named the calculus of administrative domains and the calculus of administrators. It is also proved that the logic is sound. A case study is presented signifying the logic application in practical projects.

The nuclear flow and the mass number dependence of the balance point

International Nuclear Information System (INIS)

Sebille, F.; de la Mota, V.; Remaud, B.; Schuck, P.

1990-01-01

The nuclear flow is studied theoretically with the Landau Vlasov equation in the E/A = 50 to 150 MeV energy domain using the finite range Gogny force. For comparison also other equations of states based on velocity independent mean fields are used. In this paper the mass number dependence of the balance point is investigated. A sensitivity of the flow on the equation of state as a function of mass and energies around and above the balance point can tentatively be advanced

Inflection point of environmental Kuznets curve in Mainland China

International Nuclear Information System (INIS)

Song, Ma-Lin; Zhang, Wei; Wang, Shu-Hong

2013-01-01

As environmental problems in Mainland China are receiving global increasing attentions, environmental Kuznets curve (EKC) is adopted here to validate time route of improvement for its various areas. The results indicate that some areas, such as Shanghai, Tibet, Guizhou, Jilin and Beijing have overstepped their inflection points; Liaoning, Anhui, Fujian, Hainan and Qinghai have no inflection points, and meanwhile it is about seven years for the others areas take to reach their inflection points. Therefore, it is essential to lay down some policies to change or advance the process of reaching inflection point for each area respectively. - Highlights: ► This article focuses on inflection points of EKC in various areas of Mainland China. ► Shanghai, Tibet, Guizhou, Jilin and Beijing have overstepped their inflection points. ► The inflection points for Liaoning, Anhui, Fujian, Hainan and Qinghai do not exist. ► It is about to take 1–7 years for the others to reach their inflection points

Frequency-Domain Joint Motion and Disparity Estimation Using Steerable Filters

Directory of Open Access Journals (Sweden)

Dimitrios Alexiadis

2018-02-01

Full Text Available In this paper, the problem of joint disparity and motion estimation from stereo image sequences is formulated in the spatiotemporal frequency domain, and a novel steerable filter-based approach is proposed. Our rationale behind coupling the two problems is that according to experimental evidence in the literature, the biological visual mechanisms for depth and motion are not independent of each other. Furthermore, our motivation to study the problem in the frequency domain and search for a filter-based solution is based on the fact that, according to early experimental studies, the biological visual mechanisms can be modelled based on frequency-domain or filter-based considerations, for both the perception of depth and the perception of motion. The proposed framework constitutes the first attempt to solve the joint estimation problem through a filter-based solution, based on frequency-domain considerations. Thus, the presented ideas provide a new direction of work and could be the basis for further developments. From an algorithmic point of view, we additionally extend state-of-the-art ideas from the disparity estimation literature to handle the joint disparity-motion estimation problem and formulate an algorithm that is evaluated through a number of experimental results. Comparisons with state-of-the-art-methods demonstrate the accuracy of the proposed approach.

Feature-level domain adaptation

DEFF Research Database (Denmark)

Kouw, Wouter M.; Van Der Maaten, Laurens J P; Krijthe, Jesse H.

2016-01-01

-level domain adaptation (flda), that models the dependence between the two domains by means of a feature-level transfer model that is trained to describe the transfer from source to target domain. Subsequently, we train a domain-adapted classifier by minimizing the expected loss under the resulting transfer...... modeled via a dropout distribution, which allows the classiffier to adapt to differences in the marginal probability of features in the source and the target domain. Our experiments on several real-world problems show that flda performs on par with state-of-the-art domainadaptation techniques.......Domain adaptation is the supervised learning setting in which the training and test data are sampled from different distributions: training data is sampled from a source domain, whilst test data is sampled from a target domain. This paper proposes and studies an approach, called feature...

Cross-domain interference costs during concurrent verbal and spatial serial memory tasks are asymmetric

NARCIS (Netherlands)

Morey, Candice C.; Mall, Jonathan T.

2012-01-01

Some evidence suggests that memory for serial order is domain-general. Evidence also points to asymmetries in interference between verbal and visual-spatial tasks. We confirm that concurrently remembering verbal and spatial serial lists provokes substantial interference compared with remembering a

Zero-point length from string fluctuations

International Nuclear Information System (INIS)

Fontanini, Michele; Spallucci, Euro; Padmanabhan, T.

2006-01-01

One of the leading candidates for quantum gravity, viz. string theory, has the following features incorporated in it. (i) The full spacetime is higher-dimensional, with (possibly) compact extra-dimensions; (ii) there is a natural minimal length below which the concept of continuum spacetime needs to be modified by some deeper concept. On the other hand, the existence of a minimal length (zero-point length) in four-dimensional spacetime, with obvious implications as UV regulator, has been often conjectured as a natural aftermath of any correct quantum theory of gravity. We show that one can incorporate the apparently unrelated pieces of information-zero-point length, extra-dimensions, string T-duality-in a consistent framework. This is done in terms of a modified Kaluza-Klein theory that interpolates between (high-energy) string theory and (low-energy) quantum field theory. In this model, the zero-point length in four dimensions is a 'virtual memory' of the length scale of compact extra-dimensions. Such a scale turns out to be determined by T-duality inherited from the underlying fundamental string theory. From a low energy perspective short distance infinities are cutoff by a minimal length which is proportional to the square root of the string slope, i.e., α ' . Thus, we bridge the gap between the string theory domain and the low energy arena of point-particle quantum field theory

A preliminary examination of the validity and reliability of a new brief rating scale for symptom domains of psychosis: Brief Evaluation of Psychosis Symptom Domains (BE-PSD).

Science.gov (United States)

Takeuchi, Hiroyoshi; Fervaha, Gagan; Lee, Jimmy; Agid, Ofer; Remington, Gary

2016-09-01

Brief assessments have the potential to be widely adopted as outcome measures in research but also routine clinical practice. Existing brief rating scales that assess symptoms of schizophrenia or psychosis have a number of limitations including inability to capture five symptom domains of psychosis and a lack of clearly defined operational anchor points for scoring. We developed a new brief rating scale for five symptom domains of psychosis with clearly defined operational anchor points - the Brief Evaluation of Psychosis Symptom Domains (BE-PSD). To examine the psychometric properties of the BE-PSD, fifty patients with schizophrenia or schizoaffective disorder were included in this preliminary cross-sectional study. To test the convergent and discriminant validity of the BE-PSD, correlational analyses were employed using the consensus Positive and Negative Syndrome Scale (PANSS) five-factor model. To examine the inter-rater reliability of the BE-PSD, single measures intraclass correlation coefficients (ICCs) were calculated for 11 patients. The BE-PSD domain scores demonstrated high convergent validity with the corresponding PANSS factor score (rs = 0.81-0.93) as well as good discriminant validity, as evidenced by lower correlations with the other PANSS factors (rs = 0.23-0.62). The BE-PSD also demonstrated excellent inter-rater reliability for each of the domain scores and the total scores (ICC(2,1) = 0.79-0.96). The present preliminary study found the BE-PSD measure to be valid and reliable; however, further studies are needed to establish the psychometric properties of the BE-PSD because of the limitations such as the small sample size and lacking data on test-retest reliability or sensitivity to change. Copyright © 2016 Elsevier Ltd. All rights reserved.

The SACSESS hydrometallurgy domain - an overview

Energy Technology Data Exchange (ETDEWEB)

Geist, A. [Karlsruhe Institute of Technology - KIT, Institute for Nuclear Wsaste Disposal - INE, Karlsruhe (Germany); Taylor, R. [National Nuclear Laboratory, Central Laboratory, Sellafield, Seascale, CA20 1PG (United Kingdom); Ekberg, C. [Chalmers University of Technology, Nuclear Chemistry/Industrial Materials Recycling, SE-412 96 Goeteborg (Sweden); Guilbaud, P.; Bourg, S. [CEA, Centre de Marcoule, Nuclear Energy Division, F-30207 Bagnols-sur-Ceze (France); Modolo, G. [Forschungszentrum Juelich GmbH - FZJ, Institut fuer Energie- und Klimaforschung - IEK-6, Juelich (Germany)

2016-07-01

The EURATOM FP7 project SACSESS (Safety of Actinide Separation Processes) is in continuity of a long line of preceding EURATOM projects. SACSESS is organised along four domains, one of them related to the development of hydrometallurgical (i.e. solvent extraction based) actinide separations processes. Within this domain, the most promising processes developed in previous projects are further developed, improving their technology readiness level (TRL) towards the point at which safe industrial implementation will be achievable. The SACSESS reference compounds are: TODGA, CyMe{sub 4}-BTBP, SO{sub 3}-Ph-BTP, HEDTA and DTPA. TODGA is used to co-extract actinides and lanthanides from high-acidity raffinate solutions, separating from the non-lanthanide fission products. TODGA is also used to accelerate the extraction kinetics of CyMe{sub 4}-BTBP. CyMe{sub 4}-BTBP extracts actinides selectively over lanthanides and many other fission products. HEDTA and DTPA are used to strip actinides selectively over lanthanides from an organic phase containing both actinides and lanthanides. SO{sub 3}-Ph-BTP was developed to overcome some of the drawbacks of HEDTA and DTPA, such as the narrow pH window they are effective in.

Regulatory variants of FOXG1 in the context of its topological domain organisation

DEFF Research Database (Denmark)

Mehrjouy, Mana M; Fonseca, Ana Carolina S; Ehmke, Nadja

2018-01-01

FOXG1 syndrome is caused by FOXG1 intragenic point mutations, or by long-range position effects (LRPE) of intergenic structural variants. However, the size of the FOXG1 regulatory landscape is uncertain, because the associated topologically associating domain (TAD) in fibroblasts is split into tw...

An Ontology-Based Knowledge Modelling for a Sustainability Assessment Domain

Directory of Open Access Journals (Sweden)

Agnieszka Konys

2018-01-01

Full Text Available Sustainability assessment has received more and more attention from researchers and it offers a large number of opportunities to measure and evaluate the level of its accomplishment. However, proper selection of a particular sustainability assessment approach, reflecting problem properties and the evaluator’s preferences, is a complex and important issue. Due to an existing number of different approaches dedicated to assessing, supporting, or measuring the level of sustainability and their structure oriented on the particular domain usage, problems with accurate matching frequently occur. On the other hand, the efficiency of sustainability assessment depends on the available knowledge of the ongoing capabilities. Additionally, actual research trends confirm that knowledge engineering gives a method to handle domain knowledge practically and effectively. Unfortunately, literature studies confirm that there is a lack of knowledge systematization in the sustainability assessment domain, however. The practical application of knowledge-based mechanisms may cover this gap. In this paper, we provide formal, practical and technological guidance to a knowledge management-based approach to sustainability assessment. We propose ontology as a form of knowledge conceptualization and using knowledge engineering, we make gathered knowledge publicly available and reusable, especially in terms of interoperability of collected knowledge.

PREFACE: Domain wall dynamics in nanostructures Domain wall dynamics in nanostructures

Science.gov (United States)

Marrows, C. H.; Meier, G.

2012-01-01

Domain structures in magnetic materials are ubiquitous and have been studied for decades. The walls that separate them are topological defects in the magnetic order parameter and have a wide variety of complex forms. In general, their investigation is difficult in bulk materials since only the domain structure on the surface of a specimen is visible. Cutting the sample to reveal the interior causes a rearrangement of the domains into a new form. As with many other areas of magnetism, the study of domain wall physics has been revitalised by the advent of nanotechnology. The ability to fabricate nanoscale structures has permitted the formation of simplified and controlled domain patterns; the development of advanced microscopy methods has permitted them to be imaged and then modelled; subjecting them to ultrashort field and current pulses has permitted their dynamics to be explored. The latest results from all of these advances are described in this special issue. Not only has this led to results of great scientific beauty, but also to concepts of great applicability to future information technologies. In this issue the reader will find the latest results for these domain wall dynamics and the high-speed processes of topological structures such as domain walls and magnetic vortices. These dynamics can be driven by the application of magnetic fields, or by flowing currents through spintronic devices using the novel physics of spin-transfer torque. This complexity has been studied using a wide variety of experimental techniques at the edge of the spatial and temporal resolution currently available, and can be described using sophisticated analytical theory and computational modelling. As a result, the dynamics can be engineered to give rise to finely controlled memory and logic devices with new functionality. Moreover, the field is moving to study not only the conventional transition metal ferromagnets, but also complex heterostructures, novel magnets and even other

Time-domain modeling of electromagnetic diffusion with a frequency-domain code

NARCIS (Netherlands)

Mulder, W.A.; Wirianto, M.; Slob, E.C.

2007-01-01

We modeled time-domain EM measurements of induction currents for marine and land applications with a frequency-domain code. An analysis of the computational complexity of a number of numerical methods shows that frequency-domain modeling followed by a Fourier transform is an attractive choice if a

An air-based corrugated cavity-receiver for solar parabolic trough concentrators

International Nuclear Information System (INIS)

Bader, Roman; Pedretti, Andrea; Barbato, Maurizio; Steinfeld, Aldo

2015-01-01

Highlights: • We analyze a novel tubular cavity-receiver for solar parabolic trough collectors. • Four-fold solar concentration ratio is reached compared to conventional receivers. • Efficient operation at up to 500 °C is possible. • The pumping power requirement is found to be acceptably low. - Abstract: A tubular cavity-receiver that uses air as the heat transfer fluid is evaluated numerically using a validated heat transfer model. The receiver is designed for use on a large-span (9 m net concentrator aperture width) solar parabolic trough concentrator. Through the combination of a parabolic primary concentrator with a nonimaging secondary concentrator, the collector reaches a solar concentration ratio of 97.5. Four different receiver configurations are considered, with smooth or V-corrugated absorber tube and single- or double-glazed aperture window. The collector’s performance is characterized by its optical efficiency and heat loss. The optical efficiency is determined with the Monte Carlo ray-tracing method. Radiative heat exchange inside the receiver is calculated with the net radiation method. The 2D steady-state energy equation, which couples conductive, convective, and radiative heat transfer, is solved for the solid domains of the receiver cross-section, using finite-volume techniques. Simulations for Sevilla/Spain at the summer solstice at solar noon (direct normal solar irradiance: 847 W m −2 , solar incidence angle: 13.9°) yield collector efficiencies between 60% and 65% at a heat transfer fluid temperature of 125 °C and between 37% and 42% at 500 °C, depending on the receiver configuration. The optical losses amount to more than 30% of the incident solar radiation and constitute the largest source of energy loss. For a 200 m long collector module operated between 300 and 500 °C, the isentropic pumping power required to pump the HTF through the receiver is between 11 and 17 kW

Isothermal and aniso-thermal creep in the {alpha} phase domain, {beta} phase domain and {alpha}+{beta} two phase domain in a Zr-1%NbO alloy; Fluage isotherme et anisotherme dans les domaines monophases ({alpha} et {beta}) et biphases ({alpha} et {beta}) d'un alliage Zr-1%NbO

Energy Technology Data Exchange (ETDEWEB)

Kaddour, D

2004-12-15

The coupling between phase transformation and mechanical behaviour of a Zr-1%NbO alloy was studied using an original experimental device already used in a previous study devoted to the Zy-4 alloy. The Zr-1%NbO alloy undergoes a phase transformation {alpha} (hc) {r_reversible} (cc) typically between 750 and 1000 C. The transformation temperatures were measured in situ by using the resistivity and dilatometry techniques. The isothermal creep behaviour of fuel cladding tubes was studied, first after heating, in the {alpha} phase domain between 650 and 760 C, in the {beta} phase domain between 960 and 1100 C, as well as in the ({alpha} + {beta}) two phase domain between 800 and 900 C. The results are summarized in Ashby deformation mechanism maps. It is confirmed that the {beta} phase is much more sensitive to creep flow than the {alpha} phase. The effect of microstructure on the isothermal creep flow behaviour was then investigated by first applying a thermal cycle involving either a full or a partial transformation from {alpha} to {beta}. It was investigated both in the {alpha} phase domain, and after direct cooling into the ({alpha} + {beta}) phase domain. The behaviour in aniso-thermal conditions was finally studied at heating and cooling rates of 10 and 200 C/min. In both cases, we showed that there is no significant transformation plasticity in the stress range under investigation ({<=} 5 MPa). A finite element model using Voronoi polyhedra and eventually meshing a film of intergranular {beta} phase was used to describe the behaviour of material in the ({alpha} + {beta}) domain in various microstructural states. The model predictions are in good agreement with the experimental results for the microstructure obtained after cooling, but the model underestimates creep deformation in the as-received state. This difference is probably related to the fact that interface sliding is not taken into account in the model. (author)

Novel functions of CCM1 delimit the relationship of PTB/PH domains.

Science.gov (United States)

Zhang, Jun; Dubey, Pallavi; Padarti, Akhil; Zhang, Aileen; Patel, Rinkal; Patel, Vipulkumar; Cistola, David; Badr, Ahmed

2017-10-01

relationship of PTB, PH and FERM domains has been proposed, which extends the importance of the NPXY-PTB/PH interaction on the CSC signaling and/or other cell receptors with great potential pointing to new therapeutic strategies. The study provides new insight into the structural characteristics of PTB/PH domains, essential structural elements of PTB/PH domain required for NPXY motif-binding, and function and relationship among PTB, PH and FERM domains. Copyright © 2017 Elsevier B.V. All rights reserved.

Assessment of quality of life of HIV-positive people receiving art: An Indian perspective

Directory of Open Access Journals (Sweden)

Deepika Anand

2012-01-01

Full Text Available Context: HIV/AIDS is known to affect an individual not only physically but also mentally, socially, and financially. It is a syndrome that builds a vacuum in a person affecting his/her life as a whole. Aims: The purpose of the present study is to evaluate the quality of life (QOL of people living with HIV/AIDS (PLHIV receiving ART and its association with Body mass index (BMI and CD4 count. Study Design: An observational study was performed on PLHIV receiving ART in Orissa, India. Materials and Methods: Data on sociodemographic profile, BMI, and CD4 were gathered from 153 HIV-positive subjects. QOL was assessed using WHOQOL-HIV BREF scale. Results: The overall QOL score of the subjects was moderate; PLHIV with lower BMI also had poorer QOL (P<0.05. Employment affected only the social health domain of the subjects. Men reported poorer level of independence and physical health while women reported poorer social relationships and environment. All the six domains correlated significantly with the overall QOL indicated by the G-facet. Conclusion: Attention toward improving the nutritional status of PLHIV should be accorded high priority to ensure improvement in the overall QOL of PLHIV.

Separated matter and antimatter domains with vanishing domain walls

Energy Technology Data Exchange (ETDEWEB)

Dolgov, A.D.; Godunov, S.I.; Rudenko, A.S.; Tkachev, I.I., E-mail: dolgov@fe.infn.it, E-mail: sgodunov@itep.ru, E-mail: a.s.rudenko@inp.nsk.su, E-mail: tkachev@ms2.inr.ac.ru [Physics Department and Laboratory of Cosmology and Elementary Particle Physics, Novosibirsk State University, Pirogova st. 2, Novosibirsk, 630090 (Russian Federation)

2015-10-01

We present a model of spontaneous (or dynamical) C and CP violation where it is possible to generate domains of matter and antimatter separated by cosmologically large distances. Such C(CP) violation existed only in the early universe and later it disappeared with the only trace of generated baryonic and/or antibaryonic domains. So the problem of domain walls in this model does not exist. These features are achieved through a postulated form of interaction between inflaton and a new scalar field, realizing short time C(CP) violation.

Topological Luttinger liquids from decorated domain walls

Science.gov (United States)

Parker, Daniel E.; Scaffidi, Thomas; Vasseur, Romain

2018-04-01

We introduce a systematic construction of a gapless symmetry-protected topological phase in one dimension by "decorating" the domain walls of Luttinger liquids. The resulting strongly interacting phases provide a concrete example of a gapless symmetry-protected topological (gSPT) phase with robust symmetry-protected edge modes. Using boundary conformal field theory arguments, we show that while the bulks of such gSPT phases are identical to conventional Luttinger liquids, their boundary critical behavior is controlled by a different, strongly coupled renormalization group fixed point. Our results are checked against extensive density matrix renormalization group calculations.

Characterizing implicit mental health associations across clinical domains.

Science.gov (United States)

Werntz, Alexandra J; Steinman, Shari A; Glenn, Jeffrey J; Nock, Matthew K; Teachman, Bethany A

2016-09-01

Implicit associations are relatively uncontrollable associations between concepts in memory. The current investigation focuses on implicit associations in four mental health domains (alcohol use, anxiety, depression, and eating disorders) and how these implicit associations: a) relate to explicit associations and b) self-reported clinical symptoms within the same domains, and c) vary based on demographic characteristics (age, gender, race, ethnicity, and education). Participants (volunteers over age 18 to a research website) completed implicit association (Implicit Association Tests), explicit association (self + psychopathology or attitudes toward food, using semantic differential items), and symptom measures at the Project Implicit Mental Health website tied to: alcohol use (N = 12,387), anxiety (N = 21,304), depression (N = 24,126), or eating disorders (N = 10,115). Within each domain, implicit associations showed small to moderate associations with explicit associations and symptoms, and predicted self-reported symptoms beyond explicit associations. In general, implicit association strength varied little by race and ethnicity, but showed small ties to age, gender, and education. This research was conducted on a public research and education website, where participants could take more than one of the studies. Among a large and diverse sample, implicit associations in the four domains are congruent with explicit associations and self-reported symptoms, and also add to our prediction of self-reported symptoms over and above explicit associations, pointing to the potential future clinical utility and validity of using implicit association measures with diverse populations. Copyright © 2016 Elsevier Ltd. All rights reserved.

Detection of 320 Gb/s Nyquist OTDM by polarization-insensitive time-domain optical Fourier transformation

DEFF Research Database (Denmark)

Hu, Hao; Kong, Deming; Palushani, Evarist

2013-01-01

320 Gb/s Nyquist-OTDM is generated by rectangular filtering with a bandwidth of 320 GHz and received by polarization-insensitive time-domain optical Fourier transformation (TD-OFT) followed by passive filtering. After the time-to-frequency mapping in the TD-OFT, the Nyquist-OTDM is converted into...

Dynamic working memory performance in individuals with single-domain amnestic mild cognitive impairment.

Science.gov (United States)

Guild, Emma B; Vasquez, Brandon P; Maione, Andrea M; Mah, Linda; Ween, Jon; Anderson, Nicole D

2014-01-01

Previous studies have observed poorer working memory performance in individuals with amnestic mild cognitive impairment than in healthy older adults. It is unclear, however, whether these difficulties are true only of the multiple-domain clinical subtype in whom poorer executive functioning is common. The current study examined working memory, as measured by the self-ordered pointing task (SOPT) and an n-back task, in healthy older adults and adults with single-domain amnestic mild cognitive impairment (aMCI). Individuals with single-domain aMCI committed more errors and required longer to develop an organizational strategy on the SOPT. The single-domain aMCI group did not differ from healthy older adults on the 1-back or 2-back, but had poorer discrimination on the 3-back task. This is, to our knowledge, the first characterization of dynamic working memory performance in a single-domain aMCI group. These results lend support for the idea that clinical amnestic MCI subtypes may reflect different stages on a continuum of progression to dementia and question whether standardized measures of working memory (span tasks) are sensitive enough to capture subtle changes in performance.

Altruistic Backoff: Collision Avoidance for Receiver-Initiated MAC Protocols for Wireless Sensor Networks

DEFF Research Database (Denmark)

Fafoutis, Xenofon; Orfanidis, Charalampos; Dragoni, Nicola

2014-01-01

In receiver-initiated medium access control (MAC) protocols for wireless sensor networks, communication is initiated by the receiver node which transmits beacons indicating its availability to receive data. In the case of multiple senders having traffic for a given receiver, such beacons form...... points where collisions are likely to happen. In this paper, we present altruistic backoff (AB), a novel collision avoidance mechanism that aims to avoid collisions before the transmission of a beacon. As a result of an early backoff, senders spend less time in idle listening waiting for a beacon, thus...... saving significant amounts of energy. We present an implementation of AB for Texas Instruments' eZ430-rf2500 sensor nodes and we evaluate its performance with simulations and experiments....

Melting of Domain Wall in Charge Ordered Dirac Electron of Organic Conductor α-(BEDT-TTF)2I3

Science.gov (United States)

Ohki, Daigo; Matsuno, Genki; Omori, Yukiko; Kobayashi, Akito

2018-05-01

The origin of charge order melting is identified by using the real space dependent mean-field theory in the extended Hubbard model describing an organic Dirac electron system α-(BEDT-TTF)2I3. In this model, the width of a domain wall which arises between different types of the charge ordered phase exhibits a divergent increase with decreasing the strength of electron-electron correlations. By analyzing the finite-size effect carefully, it is shown that the divergence coincides with a topological transition where a pair of Dirac cones merges in keeping with a finite gap. It is also clarified that the gap opening point and the topological transition point are different, which leads to the existence of an exotic massive Dirac electron phase with melted-type domain wall and gapless edge states. The present result also indicated that multiple metastable states are emerged in massive Dirac Electron phase. In the trivial charge ordered phase, the gapless domain-wall bound state takes place instead of the gapless edge states, accompanying with a form change of the domain wall from melted-type into hyperbolic-tangent-type.

Field-driven sense elements for chirality-dependent domain wall detection and storage

Energy Technology Data Exchange (ETDEWEB)

Bowden, S. R. [Center for Nanoscale Science and Technology, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 (United States); Maryland Nanocenter, University of Maryland, College Park, Maryland 20742 (United States); Unguris, J. [Center for Nanoscale Science and Technology, National Institute of Standards and Technology, Gaithersburg, Maryland 20899 (United States)

2013-12-14

A method for locally sensing and storing data of transverse domain wall chirality in planar nanowire logic and memory systems is presented. Patterned elements, in close proximity to the nanowires, respond to the asymmetry in the stray field from the domain wall to produce a chirality-dependent response. When a bias field is applied, a stray field-assisted reversal of the element magnetization results in a reversed remanent state, measurable by scanning electron microscopy with polarization analysis (SEMPA). The elements are designed as triangles with tips pointing toward the nanowire, allowing the shape anisotropy to be dominated by the base but having a portion with lower volume and lower energy barrier closest to the domain wall. Micromagnetic modeling assists in the design of the nanowire-triangle systems and experiments using SEMPA confirm the importance of aspect ratio and spacing given a constant bias field magnitude.

Coding and decoding in a point-to-point communication using the polarization of the light beam.

Science.gov (United States)

Kavehvash, Z; Massoumian, F

2008-05-10

A new technique for coding and decoding of optical signals through the use of polarization is described. In this technique the concept of coding is translated to polarization. In other words, coding is done in such a way that each code represents a unique polarization. This is done by implementing a binary pattern on a spatial light modulator in such a way that the reflected light has the required polarization. Decoding is done by the detection of the received beam's polarization. By linking the concept of coding to polarization we can use each of these concepts in measuring the other one, attaining some gains. In this paper the construction of a simple point-to-point communication where coding and decoding is done through polarization will be discussed.

Unbound motion on a Schwarzschild background: Practical approaches to frequency domain computations

Science.gov (United States)

Hopper, Seth

2018-03-01

Gravitational perturbations due to a point particle moving on a static black hole background are naturally described in Regge-Wheeler gauge. The first-order field equations reduce to a single master wave equation for each radiative mode. The master function satisfying this wave equation is a linear combination of the metric perturbation amplitudes with a source term arising from the stress-energy tensor of the point particle. The original master functions were found by Regge and Wheeler (odd parity) and Zerilli (even parity). Subsequent work by Moncrief and then Cunningham, Price and Moncrief introduced new master variables which allow time domain reconstruction of the metric perturbation amplitudes. Here, I explore the relationship between these different functions and develop a general procedure for deriving new higher-order master functions from ones already known. The benefit of higher-order functions is that their source terms always converge faster at large distance than their lower-order counterparts. This makes for a dramatic improvement in both the speed and accuracy of frequency domain codes when analyzing unbound motion.

A developmental screening tool for toddlers with multiple domains based on Rasch analysis.

Science.gov (United States)

Hwang, Ai-Wen; Chou, Yeh-Tai; Hsieh, Ching-Lin; Hsieh, Wu-Shiun; Liao, Hua-Fang; Wong, Alice May-Kuen

2015-01-01

Using multidomain developmental screening tools is a feasible method for pediatric health care professionals to identify children at risk of developmental problems in multiple domains simultaneously. The purpose of this study was to develop a Rasch-based tool for Multidimensional Screening in Child Development (MuSiC) for children aged 0-3 years. The MuSic was developed by constructing items bank based on three commonly used screening tools, validating with developmental status (at risk for delay or not) on five developmental domains. Parents of a convenient sample of 632 children (aged 3-35.5 months) with and without developmental delays responded to items from the three screening tools funded by health authorities in Taiwan. Item bank was determined by item fit of Rasch analysis for each of the five developmental domains (cognitive skills, language skills, gross motor skills, fine motor skills, and socioadaptive skills). Children's performance scores in logits derived in Rasch analysis were validated with developmental status for each domain using the area under receiver operating characteristic curves. MuSiC, a 75-item developmental screening tool for five domains, was derived. The diagnostic validity of all five domains was acceptable for all stages of development, except for the infant stage (≤11 months and 15 days). MuSiC can be applied simultaneously to well-child care visits as a universal screening tool for children aged 1-3 years on multiple domains. Items with sound validity for infants need to be further developed. Copyright © 2014. Published by Elsevier B.V.

Bridges between multiple-point geostatistics and texture synthesis: Review and guidelines for future research

Science.gov (United States)

Mariethoz, Gregoire; Lefebvre, Sylvain

2014-05-01

Multiple-Point Simulations (MPS) is a family of geostatistical tools that has received a lot of attention in recent years for the characterization of spatial phenomena in geosciences. It relies on the definition of training images to represent a given type of spatial variability, or texture. We show that the algorithmic tools used are similar in many ways to techniques developed in computer graphics, where there is a need to generate large amounts of realistic textures for applications such as video games and animated movies. Similarly to MPS, these texture synthesis methods use training images, or exemplars, to generate realistic-looking graphical textures. Both domains of multiple-point geostatistics and example-based texture synthesis present similarities in their historic development and share similar concepts. These disciplines have however remained separated, and as a result significant algorithmic innovations in each discipline have not been universally adopted. Texture synthesis algorithms present drastically increased computational efficiency, patterns reproduction and user control. At the same time, MPS developed ways to condition models to spatial data and to produce 3D stochastic realizations, which have not been thoroughly investigated in the field of texture synthesis. In this paper we review the possible links between these disciplines and show the potential and limitations of using concepts and approaches from texture synthesis in MPS. We also provide guidelines on how recent developments could benefit both fields of research, and what challenges remain open.

Domain Walls and Matter-Antimatter Domains in the Early Universe

Directory of Open Access Journals (Sweden)

Dolgov A.D.

2017-01-01

Full Text Available We suggest a scenario of spontaneous (or dynamical C and CP violation according to which it is possible to generate domains of matter and antimatter separated by cosmologically large distances. Such C(CP violation existed only in the early universe and later it disappeared with the only trace of generated matter and antimatter domains. So this scenario does not suffer from the problem of domain walls. According to this scenario the width of the domain wall should grow exponentially to prevent annihilation at the domain boundaries. Though there is a classical result obtained by Basu and Vilenkin that the width of the wall tends to the one of the stationary solution (constant physical width. That is why we considered thick domain walls in a de Sitter universe following paper by Basu and Vilenkin. However, we were interested not only in stationary solutions found therein, but also investigated the general case of domain wall evolution with time. When the wall thickness parameter, δ0 , is smaller than H−1/2 where H is the Hubble parameter in de Sitter space-time, then the stationary solutions exist, and initial field configurations tend with time to the stationary ones. However, there are no stationary solutions for δ0>H−1/2 We have calculated numerically the rate of the wall expansion in this case and have found that the width of the wall grows exponentially fast for δ0≫H−1 An explanation for the critical value δ0c=H−1/2 is also proposed.

Customer Order Decoupling Point Selection Model in Mass Customization Based on MAS

Institute of Scientific and Technical Information of China (English)

XU Xuanguo; LI Xiangyang

2006-01-01

Mass customization relates to the ability of providing individually designed products or services to customer with high process flexibility or integration. Literatures on mass customization have been focused on mechanism of MC, but little on customer order decoupling point selection. The aim of this paper is to present a model for customer order decoupling point selection of domain knowledge interactions between enterprises and customers in mass customization. Based on the analysis of other researchers' achievements combining the demand problems of customer and enterprise, a model of group decision for customer order decoupling point selection is constructed based on quality function deployment and multi-agent system. Considering relatively the decision makers of independent functional departments as independent decision agents, a decision agent set is added as the third dimensionality to house of quality, the cubic quality function deployment is formed. The decision-making can be consisted of two procedures: the first one is to build each plane house of quality in various functional departments to express each opinions; the other is to evaluate and gather the foregoing sub-decisions by a new plane quality function deployment. Thus, department decision-making can well use its domain knowledge by ontology, and total decision-making can keep simple by avoiding too many customer requirements.

Compressed Sensing Methods in Radio Receivers Exposed to Noise and Interference

DEFF Research Database (Denmark)

Pierzchlewski, Jacek

, there is a problem of interference, which makes digitization of radio receivers even more dicult. High-order low-pass lters are needed to remove interfering signals and secure a high-quality reception. In the mid-2000s a new method of signal acquisition, called compressed sensing, emerged. Compressed sensing...... the downconverted baseband signal and interference, may be replaced by low-order lters. Additional digital signal processing is a price to pay for this feature. Hence, the signal processing is moved from the analog to the digital domain. Filtering compressed sensing, which is a new application of compressed sensing...

Graphene Dirac point tuned by ferroelectric polarization field

Science.gov (United States)

Wang, Xudong; Chen, Yan; Wu, Guangjian; Wang, Jianlu; Tian, Bobo; Sun, Shuo; Shen, Hong; Lin, Tie; Hu, Weida; Kang, Tingting; Tang, Minghua; Xiao, Yongguang; Sun, Jinglan; Meng, Xiangjian; Chu, Junhao

2018-04-01

Graphene has received numerous attention for future nanoelectronics and optoelectronics. The Dirac point is a key parameter of graphene that provides information about its carrier properties. There are lots of methods to tune the Dirac point of graphene, such as chemical doping, impurities, defects, and disorder. In this study, we report a different approach to tune the Dirac point of graphene using a ferroelectric polarization field. The Dirac point can be adjusted to near the ferroelectric coercive voltage regardless its original position. We have ensured this phenomenon by temperature-dependent experiments, and analyzed its mechanism with the theory of impurity correlation in graphene. Additionally, with the modulation of ferroelectric polymer, the current on/off ratio and mobility of graphene transistor both have been improved. This work provides an effective method to tune the Dirac point of graphene, which can be readily used to configure functional devices such as p-n junctions and inverters.

Cosmic bubble and domain wall instabilities II: fracturing of colliding walls

Energy Technology Data Exchange (ETDEWEB)

Braden, Jonathan [CITA, University of Toronto,60 St. George Street, Toronto, ON, M5S 3H8 (Canada); Department of Physics, University of Toronto,60 St. George Street, Toronto, ON, M5S 3H8 (Canada); Department of Physics and Astronomy, University College London,Gower Street, London, WC1E 6BT (United Kingdom); Bond, J. Richard [CITA, University of Toronto,60 St. George Street, Toronto, ON, M5S 3H8 (Canada); Mersini-Houghton, Laura [Department of Physics and Astronomy, University of North Carolina-Chapel Hill,1 Phillips Hall, 120 E. Cameron Avenue, Chapel Hill, NC 27599-3255 (United States)

2015-08-26

We study collisions between nearly planar domain walls including the effects of small initial nonplanar fluctuations. These perturbations represent the small fluctuations that must exist in a quantum treatment of the problem. In a previous paper, we demonstrated that at the linear level a subset of these fluctuations experience parametric amplification as a result of their coupling to the planar symmetric background. Here we study the full three-dimensional nonlinear dynamics using lattice simulations, including both the early time regime when the fluctuations are well described by linear perturbation theory as well as the subsequent stage of fully nonlinear evolution. We find that the nonplanar fluctuations have a dramatic effect on the overall evolution of the system. Specifically, once these fluctuations begin to interact nonlinearly the split into a planar symmetric part of the field and the nonplanar fluctuations loses its utility. At this point the colliding domain walls dissolve, with the endpoint of this being the creation of a population of oscillons in the collision region. The original (nearly) planar symmetry has been completely destroyed at this point and an accurate study of the system requires the full three-dimensional simulation.

Cosmic bubble and domain wall instabilities II: fracturing of colliding walls

Energy Technology Data Exchange (ETDEWEB)

Braden, Jonathan; Bond, J. Richard [CITA, University of Toronto, 60 St. George Street, Toronto, ON, M5S 3H8 (Canada); Mersini-Houghton, Laura, E-mail: j.braden@ucl.ac.uk, E-mail: bond@cita.utoronto.ca, E-mail: mersini@physics.unc.edu [Department of Physics and Astronomy, University of North Carolina-Chapel Hill, 1 Phillips Hall, 120 E. Cameron Avenue, Chapel Hill, NC 27599-3255 (United States)

2015-08-01

We study collisions between nearly planar domain walls including the effects of small initial nonplanar fluctuations. These perturbations represent the small fluctuations that must exist in a quantum treatment of the problem. In a previous paper, we demonstrated that at the linear level a subset of these fluctuations experience parametric amplification as a result of their coupling to the planar symmetric background. Here we study the full three-dimensional nonlinear dynamics using lattice simulations, including both the early time regime when the fluctuations are well described by linear perturbation theory as well as the subsequent stage of fully nonlinear evolution. We find that the nonplanar fluctuations have a dramatic effect on the overall evolution of the system. Specifically, once these fluctuations begin to interact nonlinearly the split into a planar symmetric part of the field and the nonplanar fluctuations loses its utility. At this point the colliding domain walls dissolve, with the endpoint of this being the creation of a population of oscillons in the collision region. The original (nearly) planar symmetry has been completely destroyed at this point and an accurate study of the system requires the full three-dimensional simulation.

Cosmic bubble and domain wall instabilities II: fracturing of colliding walls

International Nuclear Information System (INIS)

Braden, Jonathan; Bond, J. Richard; Mersini-Houghton, Laura

2015-01-01

We study collisions between nearly planar domain walls including the effects of small initial nonplanar fluctuations. These perturbations represent the small fluctuations that must exist in a quantum treatment of the problem. In a previous paper, we demonstrated that at the linear level a subset of these fluctuations experience parametric amplification as a result of their coupling to the planar symmetric background. Here we study the full three-dimensional nonlinear dynamics using lattice simulations, including both the early time regime when the fluctuations are well described by linear perturbation theory as well as the subsequent stage of fully nonlinear evolution. We find that the nonplanar fluctuations have a dramatic effect on the overall evolution of the system. Specifically, once these fluctuations begin to interact nonlinearly the split into a planar symmetric part of the field and the nonplanar fluctuations loses its utility. At this point the colliding domain walls dissolve, with the endpoint of this being the creation of a population of oscillons in the collision region. The original (nearly) planar symmetry has been completely destroyed at this point and an accurate study of the system requires the full three-dimensional simulation

A Bayesian Sampler for Optimization of Protein Domain Hierarchies

Science.gov (United States)

2014-01-01

Abstract The process of identifying and modeling functionally divergent subgroups for a specific protein domain class and arranging these subgroups hierarchically has, thus far, largely been done via manual curation. How to accomplish this automatically and optimally is an unsolved statistical and algorithmic problem that is addressed here via Markov chain Monte Carlo sampling. Taking as input a (typically very large) multiple-sequence alignment, the sampler creates and optimizes a hierarchy by adding and deleting leaf nodes, by moving nodes and subtrees up and down the hierarchy, by inserting or deleting internal nodes, and by redefining the sequences and conserved patterns associated with each node. All such operations are based on a probability distribution that models the conserved and divergent patterns defining each subgroup. When we view these patterns as sequence determinants of protein function, each node or subtree in such a hierarchy corresponds to a subgroup of sequences with similar biological properties. The sampler can be applied either de novo or to an existing hierarchy. When applied to 60 protein domains from multiple starting points in this way, it converged on similar solutions with nearly identical log-likelihood ratio scores, suggesting that it typically finds the optimal peak in the posterior probability distribution. Similarities and differences between independently generated, nearly optimal hierarchies for a given domain help distinguish robust from statistically uncertain features. Thus, a future application of the sampler is to provide confidence measures for various features of a domain hierarchy. PMID:24494927

Temperature-induced transitions between domain structures of ultrathin magnetic films

International Nuclear Information System (INIS)

Polyakova, T.; Zablotskii, V.

2005-01-01

Full text: Understanding of the influence of temperature on behavior of domain patterns of ultrathin magnetic films is of high significance for the fundamental physics of nanomagnetism as well as for technological applications. A thickness-dependent Curie temperature of ultrathin films may cause many interesting phenomena in the thermal evolution of domain structures (DS): i) nontrivial changes of the anisotropy constants as a function of the film thickness; ii) so-called inverse melting of DSs (processes where a more symmetric domain phase is found at lower temperatures than at higher temperatures - the inverse phase sequence) [1]; iii) temperature-induced transitions between domain structures. The possibility of such transitions is determined by lowering of the potential barriers separating different magnetization states as the film temperature approaches the Curie point. In this case with an increase of temperature, due to a significant decrease of the anisotropy constant, the domain wall energy is low enough and allows the system to reach equilibrium by a change of the domain wall number in the sample. This manifests itself in a transition from a metastable DS to a more stable DS which corresponds to new values of the anisotropy constant and magnetizations saturation. Thus, the temperature-induced transitions are driven by temperature changes of the magnetic parameters of the film. The key parameters controlling the DS geometry and period are the characteristic length, l c =σ/4πM S 2 (the ratio between the domain wall and demagnetization energies), and the quality factor Q =K/2πM S 2 (K is the first anisotropy constant). We show that for films with a pronounced nonmonotonic temperature dependence of l c one can expect a counter thermodynamic behavior: the inverse phase sequence and cooling-induced disordering. On changing temperature the existing domain structure should accommodate itself under new magnitudes of l c and Q. There are the two possible

Generalized Mann Iterations for Approximating Fixed Points of a Family of Hemicontractions

Directory of Open Access Journals (Sweden)

Jin Liang

2008-06-01

Full Text Available This paper concerns common fixed points for a finite family of hemicontractions or a finite family of strict pseudocontractions on uniformly convex Banach spaces. By introducing a new iteration process with error term, we obtain sufficient and necessary conditions, as well as sufficient conditions, for the existence of a fixed point. As one will see, we derive these strong convergence theorems in uniformly convex Banach spaces and without any requirement of the compactness on the domain of the mapping. The results given in this paper extend some previous theorems.

On the number of lattice points in three-dimensional solids of revolution

International Nuclear Information System (INIS)

Popov, D A

2000-01-01

We derive an accurate estimate for the order of magnitude of the remainder term in the problem of the number of lattice points in families of homothetic domains belonging to the class of three-dimensional solids of revolution with smooth boundaries (under certain additional conditions). This estimate is realized in the case of the solid bounded by a standardly embedded torus, for which the second term of the expansion, which describes the dependence of the number of lattice points on the dilation parameter, is written in explicit form

Gravitational waveforms from a point particle orbiting a Schwarzschild black hole

International Nuclear Information System (INIS)

Martel, Karl

2004-01-01

We numerically solve the inhomogeneous Zerilli-Moncrief and Regge-Wheeler equations in the time domain. We obtain the gravitational waveforms produced by a point particle of mass μ traveling around a Schwarzschild black hole of mass M on arbitrary bound and unbound orbits. Fluxes of energy and angular momentum at infinity and the event horizon are also calculated. Results for circular orbits, selected cases of eccentric orbits, and parabolic orbits are presented. The numerical results from the time-domain code indicate that, for all three types of orbital motion, black hole absorption contributes less than 1% of the total flux, so long as the orbital radius r p (t) satisfies r p (t)>5M at all times

Assessment of the impact of point source pollution from the ...

African Journals Online (AJOL)

Assessment of the impact of point source pollution from the Keiskammahoek Sewage ... Water SA. Journal Home · ABOUT THIS JOURNAL · Advanced Search ... Also, significant pollution of the receiving Keiskamma River was indicated for ...

Optimal convergence recovery for the Fourier-finite-element approximation of Maxwell's equations in non-smooth axisymmetric domains

International Nuclear Information System (INIS)

Nkemzi, B.

2005-10-01

Three-dimensional time-harmonic Maxwell's problems in axisymmetric domains Ω-circumflex with edges and conical points on the boundary are treated by means of the Fourier-finite-element method. The Fourier-fem combines the approximating Fourier series expansion of the solution with respect to the rotational angle using trigonometric polynomials of degree N (N → ∞), with the finite element approximation of the Fourier coefficients on the plane meridian domain Ω a is a subset of R + 2 of Ω-circumflex with mesh size h (h → 0). The singular behaviors of the Fourier coefficients near angular points of the domain Ω a are fully described by suitable singular functions and treated numerically by means of the singular function method with the finite element method on graded meshes. It is proved that the rate of convergence of the mixed approximations in H 1 (Ω-circumflex) 3 is of the order O (h+N -1 ) as known for the classical Fourier-finite-element approximation of problems with regular solutions. (author)

Higher-order triangular spectral element method with optimized cubature points for seismic wavefield modeling

Science.gov (United States)

Liu, Youshan; Teng, Jiwen; Xu, Tao; Badal, José

2017-05-01

The mass-lumped method avoids the cost of inverting the mass matrix and simultaneously maintains spatial accuracy by adopting additional interior integration points, known as cubature points. To date, such points are only known analytically in tensor domains, such as quadrilateral or hexahedral elements. Thus, the diagonal-mass-matrix spectral element method (SEM) in non-tensor domains always relies on numerically computed interpolation points or quadrature points. However, only the cubature points for degrees 1 to 6 are known, which is the reason that we have developed a p-norm-based optimization algorithm to obtain higher-order cubature points. In this way, we obtain and tabulate new cubature points with all positive integration weights for degrees 7 to 9. The dispersion analysis illustrates that the dispersion relation determined from the new optimized cubature points is comparable to that of the mass and stiffness matrices obtained by exact integration. Simultaneously, the Lebesgue constant for the new optimized cubature points indicates its surprisingly good interpolation properties. As a result, such points provide both good interpolation properties and integration accuracy. The Courant-Friedrichs-Lewy (CFL) numbers are tabulated for the conventional Fekete-based triangular spectral element (TSEM), the TSEM with exact integration, and the optimized cubature-based TSEM (OTSEM). A complementary study demonstrates the spectral convergence of the OTSEM. A numerical example conducted on a half-space model demonstrates that the OTSEM improves the accuracy by approximately one order of magnitude compared to the conventional Fekete-based TSEM. In particular, the accuracy of the 7th-order OTSEM is even higher than that of the 14th-order Fekete-based TSEM. Furthermore, the OTSEM produces a result that can compete in accuracy with the quadrilateral SEM (QSEM). The high accuracy of the OTSEM is also tested with a non-flat topography model. In terms of computational

Sheared Layers in the Continental Crust: Nonlinear and Linearized inversion for Ps receiver functions

Science.gov (United States)

Park, J. J.

2017-12-01

Sheared Layers in the Continental Crust: Nonlinear and Linearized inversion for Ps receiver functions Jeffrey Park, Yale University The interpretation of seismic receiver functions (RFs) in terms of isotropic and anisotropic layered structure can be complex. The relationship between structure and body-wave scattering is nonlinear. The anisotropy can involve more parameters than the observations can readily constrain. Finally, reflectivity-predicted layer reverberations are often not prominent in data, so that nonlinear waveform inversion can search in vain to match ghost signals. Multiple-taper correlation (MTC) receiver functions have uncertainties in the frequency domain that follow Gaussian statistics [Park and Levin, 2016a], so grid-searches for the best-fitting collections of interfaces can be performed rapidly to minimize weighted misfit variance. Tests for layer-reverberations can be performed in the frequency domain without reflectivity calculations, allowing flexible modelling of weak, but nonzero, reverberations. Park and Levin [2016b] linearized the hybridization of P and S body waves in an anisotropic layer to predict first-order Ps conversion amplitudes at crust and mantle interfaces. In an anisotropic layer, the P wave acquires small SV and SH components. To ensure continuity of displacement and traction at the top and bottom boundaries of the layer, shear waves are generated. Assuming hexagonal symmetry with an arbitrary symmetry axis, theory confirms the empirical stacking trick of phase-shifting transverse RFs by 90 degrees in back-azimuth [Shiomi and Park, 2008; Schulte-Pelkum and Mahan, 2014] to enhance 2-lobed and 4-lobed harmonic variation. Ps scattering is generated by sharp interfaces, so that RFs resemble the first derivative of the model. MTC RFs in the frequency domain can be manipulated to obtain a first-order reconstruction of the layered anisotropy, under the above modeling constraints and neglecting reverberations. Examples from long

Impact assessment of treated wastewater on water quality of the receiver using the Wilcoxon test

Directory of Open Access Journals (Sweden)

Ofman Piotr

2017-01-01

Full Text Available Wastewater treatment is a process which aims to reduce the concentration of pollutants in wastewater to the level allowed by current regulations. This is to protect the receivers which typically are rivers, streams, lakes. Examination of the quality of treated wastewater allows for quick elimination of possible negative effects, and the study of water receiver prevents from excessive contamination. The paper presents the results of selected physical and chemical parameters of treated wastewater from the largest on the region in north-eastern Poland city of Bialystok municipal wastewater treatment and Biała River, the receiver. The samples for research were taken 3–4 a month in 2015 from two points: before and after discharge. The impact of the wastewater treatment plant on the quality of the receiver waters was studied by using non-parametric Wilcoxon test. This test determined whether the analyzed indicators varied significantly depending on different sampling points of the river, above and below place of discharge of treated wastewater. These results prove that the treated wastewater does not affect the water quality in the Biała River.

PERFORMANCE ASSESSMENT OF INTEGRATED SENSOR ORIENTATION WITH A LOW-COST GNSS RECEIVER

Directory of Open Access Journals (Sweden)

M. Rehak

2017-08-01

Full Text Available Mapping with Micro Aerial Vehicles (MAVs whose weight does not exceed 5 kg is gaining importance in applications such as corridor mapping, road and pipeline inspections, or mapping of large areas with homogeneous surface structure, e.g. forest or agricultural fields. In these challenging scenarios, integrated sensor orientation (ISO improves effectiveness and accuracy. Furthermore, in block geometry configurations, this mode of operation allows mapping without ground control points (GCPs. Accurate camera positions are traditionally determined by carrier-phase GNSS (Global Navigation Satellite System positioning. However, such mode of positioning has strong requirements on receiver’s and antenna’s performance. In this article, we present a mapping project in which we employ a single-frequency, low-cost (< $100 GNSS receiver on a MAV. The performance of the low-cost receiver is assessed by comparing its trajectory with a reference trajectory obtained by a survey-grade, multi-frequency GNSS receiver. In addition, the camera positions derived from these two trajectories are used as observations in bundle adjustment (BA projects and mapping accuracy is evaluated at check points (ChP. Several BA scenarios are considered with absolute and relative aerial position control. Additionally, the presented experiments show the possibility of BA to determine a camera-antenna spatial offset, so-called lever-arm.

Domain Decomposition Solvers for Frequency-Domain Finite Element Equations

KAUST Repository

Copeland, Dylan

2010-10-05

The paper is devoted to fast iterative solvers for frequency-domain finite element equations approximating linear and nonlinear parabolic initial boundary value problems with time-harmonic excitations. Switching from the time domain to the frequency domain allows us to replace the expensive time-integration procedure by the solution of a simple linear elliptic system for the amplitudes belonging to the sine- and to the cosine-excitation or a large nonlinear elliptic system for the Fourier coefficients in the linear and nonlinear case, respectively. The fast solution of the corresponding linear and nonlinear system of finite element equations is crucial for the competitiveness of this method. © 2011 Springer-Verlag Berlin Heidelberg.

Domain Decomposition Solvers for Frequency-Domain Finite Element Equations

KAUST Repository

Copeland, Dylan; Kolmbauer, Michael; Langer, Ulrich

2010-01-01

The paper is devoted to fast iterative solvers for frequency-domain finite element equations approximating linear and nonlinear parabolic initial boundary value problems with time-harmonic excitations. Switching from the time domain to the frequency domain allows us to replace the expensive time-integration procedure by the solution of a simple linear elliptic system for the amplitudes belonging to the sine- and to the cosine-excitation or a large nonlinear elliptic system for the Fourier coefficients in the linear and nonlinear case, respectively. The fast solution of the corresponding linear and nonlinear system of finite element equations is crucial for the competitiveness of this method. © 2011 Springer-Verlag Berlin Heidelberg.

Regularity of p(ṡ)-superharmonic functions, the Kellogg property and semiregular boundary points

Science.gov (United States)

Adamowicz, Tomasz; Björn, Anders; Björn, Jana

2014-11-01

We study various boundary and inner regularity questions for $p(\\cdot)$-(super)harmonic functions in Euclidean domains. In particular, we prove the Kellogg property and introduce a classification of boundary points for $p(\\cdot)$-harmonic functions into three disjoint classes: regular, semiregular and strongly irregular points. Regular and especially semiregular points are characterized in many ways. The discussion is illustrated by examples. Along the way, we present a removability result for bounded $p(\\cdot)$-harmonic functions and give some new characterizations of $W^{1, p(\\cdot)}_0$ spaces. We also show that $p(\\cdot)$-superharmonic functions are lower semicontinuously regularized, and characterize them in terms of lower semicontinuously regularized supersolutions.

Intrabody construction and expression. I. The critical role of VL domain stability.

Science.gov (United States)

Ohage, E; Steipe, B

1999-09-03

We have constructed a panel of hyperstable immunoglobulin VL domains by a rational approach of consensus sequence engineering and combining stabilizing point mutations. These prototype domains unfold fully reversibly, even when the conserved structural disulfide bridge is reduced. This has allowed us to probe the factors that limit the expression yield of soluble immunoglobulin domains in the reducing environment of the cytoplasm (intrabodies). The most important factor is thermodynamic stability, and there is an excellent quantitative correlation between stability and yield. Surprisingly, an unprocessed N-terminal methionine residue can severely compromise VL stability, but this problem can be overcome by changing the amino acid following the initiator methionine residue. Transcription from the strong T7 promoter does not increase the amount of soluble material over that obtained from the tetA promoter, but large amounts of inclusions bodies can be obtained. Elevated temperature shifts protein from a productive folding pathway to aggregation. The structural disulfide bridge does not form in the cytoplasm, but the two consensus cysteine residues can be quantitatively oxidized in vitro. In summary, stability engineering provides a plannable route to the high-yield cytoplasmic expression of functional intrabody domains.

Defect-selective dry etching for quick and easy probing of hexagonal boron nitride domains

Science.gov (United States)

Wu, Qinke; Lee, Joohyun; Park, Sangwoo; Woo, Hwi Je; Lee, Sungjoo; Song, Young Jae

2018-03-01

In this study, we demonstrate a new method to selectively etch the point defects or the boundaries of as-grown hexagonal boron nitride (hBN) films and flakes in situ on copper substrates using hydrogen and argon gases. The initial quality of the chemical vapor deposition-grown hBN films and flakes was confirmed by UV-vis absorption spectroscopy, atomic force microscopy, and transmission electron microscopy. Different gas flow ratios of Ar/H2 were then employed to etch the same quality of samples and it was found that etching with hydrogen starts from the point defects and grows epitaxially, which helps in confirming crystalline orientations. However, etching with argon is sensitive to line defects (boundaries) and helps in visualizing the domain size. Finally, based on this defect-selective dry etching technique, it could be visualized that the domains of a polycrystalline hBN monolayer merged together with many parts, even with those that grew from a single nucleation seed.

Control systems using modal domain optical fiber sensors for smart structure applications

Science.gov (United States)

Lindner, Douglas K.; Reichard, Karl M.

1991-01-01

Recently, a new class of sensors has emerged for structural control which respond to environmental changes over a significant gauge length; these sensors are called distributed-effect sensors. These sensors can be fabricated with spatially varying sensitivity to the distributed measurand, and can be configured to measure a variety of structural parameters which can not be measured directly using point sensors. Examples of distributed-effect sensors include piezoelectric film, holographic sensors, and modal domain optical fiber sensors. Optical fiber sensors are particularly attractive for smart structure applications because they are flexible, have low mass, and can easily be embedded directly into materials. In this paper we describe the implementation of weighted modal domain optical fiber sensors. The mathematical model of the modal domain optical fiber sensor model is described and used to derive an expression for the sensor sensitivity. The effects of parameter variations on the sensor sensitivity are demonstrated to illustrate methods of spatially varying the sensor sensitivity.

Domain shape instabilities and dendrite domain growth in uniaxial ferroelectrics

Science.gov (United States)

Shur, Vladimir Ya.; Akhmatkhanov, Andrey R.

2018-01-01

The effects of domain wall shape instabilities and the formation of nanodomains in front of moving walls obtained in various uniaxial ferroelectrics are discussed. Special attention is paid to the formation of self-assembled nanoscale and dendrite domain structures under highly non-equilibrium switching conditions. All obtained results are considered in the framework of the unified kinetic approach to domain structure evolution based on the analogy with first-order phase transformation. This article is part of the theme issue `From atomistic interfaces to dendritic patterns'.

The Lithospheric Structure Beneath Canary Islands from Receiver Function Analysis

Science.gov (United States)

Martinez-Arevalo, C.; Mancilla, F.; Helffrich, G. R.; Garcia, A.

2009-12-01

The Canary Archipelago is located a few hundred kilometers off the western Moroccan coast, extending 450 km west-to-east. It is composed of seven main islands. All but one have been active in the last million years. The origin of the Canary Islands is not well established and local and regional geology features cannot be completely explained by the current models. The main aim of this study is to provide new data that help us to understand and constrain the archipelago's origin and tectonic evolution. The crustal structure under each station is obtained applying P-receiver function technique to the teleseismic P arrivals recorded by the broadband seismic network installed at the Canary Island by the Instituto Geográfico Nacional (IGN) and two temporary stations (MIDSEA and IRIS). We computed receiver functions using the Extended-Time Multitaper Frequency Domain Cross-Correlation Receiver Function (ET-MTRF) method. The results show that the crust is thicker, around 22 km, in the eastern islands (Fuerteventura and Lanzarote) than in the western ones (El Hierro, La Palma, Tenerife), around 17 km, with the exception of La Gomera island. This island, located in the west, exhibits similar crustal structure to Fuerteventura and Lanzarote. A discontinuity at 70-80 km, possibly the LAB (Lithosphere Asthenosphere Boundary) is clearly observed in all the stations. It appears that Moho depths do not track the LAB discontinuity.

Real-time multi-GNSS single-frequency precise point positioning

NARCIS (Netherlands)

de Bakker, P.F.; Tiberius, C.C.J.M.

2017-01-01

Precise Point Positioning (PPP) is a popular Global Positioning System (GPS) processing strategy, thanks to its high precision without requiring additional GPS infrastructure. Single-Frequency PPP (SF-PPP) takes this one step further by no longer relying on expensive dual-frequency GPS receivers,

Large Aperture "Photon Bucket" Optical Receiver Performance in High Background Environments

Science.gov (United States)

Vilnrotter, Victor A.; Hoppe, D.

2011-01-01

The potential development of large aperture groundbased "photon bucket" optical receivers for deep space communications, with acceptable performance even when pointing close to the sun, is receiving considerable attention. Sunlight scattered by the atmosphere becomes significant at micron wavelengths when pointing to a few degrees from the sun, even with the narrowest bandwidth optical filters. In addition, high quality optical apertures in the 10-30 meter range are costly and difficult to build with accurate surfaces to ensure narrow fields-of-view (FOV). One approach currently under consideration is to polish the aluminum reflector panels of large 34-meter microwave antennas to high reflectance, and accept the relatively large FOV generated by state-of-the-art polished aluminum panels with rms surface accuracies on the order of a few microns, corresponding to several-hundred micro-radian FOV, hence generating centimeter-diameter focused spots at the Cassegrain focus of 34-meter antennas. Assuming pulse-position modulation (PPM) and Poisson-distributed photon-counting detection, a "polished panel" photon-bucket receiver with large FOV will collect hundreds of background photons per PPM slot, along with comparable signal photons due to its large aperture. It is demonstrated that communications performance in terms of PPM symbol-error probability in high-background high-signal environments depends more strongly on signal than on background photons, implying that large increases in background energy can be compensated by a disproportionally small increase in signal energy. This surprising result suggests that large optical apertures with relatively poor surface quality may nevertheless provide acceptable performance for deep-space optical communications, potentially enabling the construction of cost-effective hybrid RF/optical receivers in the future.

Prevalence of major depressive disorder in patients receiving beta-blocker therapy versus other medications.

Science.gov (United States)

Carney, R M; Rich, M W; teVelde, A; Saini, J; Clark, K; Freedland, K E

1987-08-01

Depression is believed to be a common side effect in patients receiving beta-blocker therapy. However, diagnoses of depression defined by current diagnostic criteria may not be more common in patients receiving beta-blockers than in patients with the same medical disorder receiving other medications. Seventy-seven patients undergoing elective cardiac catheterization for evaluation of chest pain received a semi-structured diagnostic psychiatric interview. Twenty-one percent of the patients receiving beta-blockers and 33 percent of the patients receiving medications other than beta-blockers met the current American Psychiatric Association criteria for major depressive disorder (DSM-III) (p = NS). The mean heart rate and state anxiety scores for patients taking beta-blockers were significantly lower than those measured in patients taking medications other than beta-blockers. No other medical or demographic differences were observed between the two groups. Despite the methodologic limitations of the study, there does not appear to be a difference in the point prevalence of depression between patients receiving beta-blockers and those receiving other medications.

Expert Knowledge Influences Decision-Making for Couples Receiving Positive Prenatal Chromosomal Microarray Testing Results.

Science.gov (United States)

Rubel, M A; Werner-Lin, A; Barg, F K; Bernhardt, B A

2017-09-01

To assess how participants receiving abnormal prenatal genetic testing results seek information and understand the implications of results, 27 US female patients and 12 of their male partners receiving positive prenatal microarray testing results completed semi-structured phone interviews. These interviews documented participant experiences with chromosomal microarray testing, understanding of and emotional response to receiving results, factors affecting decision-making about testing and pregnancy termination, and psychosocial needs throughout the testing process. Interview data were analyzed using a modified grounded theory approach. In the absence of certainty about the implications of results, understanding of results is shaped by biomedical expert knowledge (BEK) and cultural expert knowledge (CEK). When there is a dearth of BEK, as in the case of receiving results of uncertain significance, participants rely on CEK, including religious/spiritual beliefs, "gut instinct," embodied knowledge, and social network informants. CEK is a powerful platform to guide understanding of prenatal genetic testing results. The utility of culturally situated expert knowledge during testing uncertainty emphasizes that decision-making occurs within discourses beyond the biomedical domain. These forms of "knowing" may be integrated into clinical consideration of efficacious patient assessment and counseling.

The Simulation Realization of Pavement Roughness in the Time Domain

Science.gov (United States)

XU, H. L.; He, L.; An, D.

2017-10-01

As the needs for the dynamic study on the vehicle-pavement system and the simulated vibration table test, how to simulate the pavement roughness actually is important guarantee for whether calculation and test can reflect the actual situation or not. Using the power spectral density function, the simulation of pavement roughness can be realized by Fourier inverse transform. The main idea of this method was that the spectrum amplitude and random phase were obtained separately according to the power spectrum, and then the simulation of pavement roughness was obtained in the time domain through the Fourier inverse transform (IFFT). In the process, the sampling interval (Δl) was 0.1m, and the sampling points(N) was 4096, which satisfied the accuracy requirements. Using this method, the simulate results of pavement roughness (A~H grades) were obtain in the time domain.

Inter-domain networking innovation on steroids: empowering ixps with SDN capabilities

KAUST Repository

Chiesa, Marco

2016-10-14

While innovation in inter-domain routing has remained stagnant for over a decade, Internet exchange points (IXPs) are consolidating their role as economically advantageous interconnection points for reducing path latencies and exchanging ever increasing amounts of traffic. As such, IXPs appear as a natural place to foster network innovation and assess the benefits of SDN, a recent technological trend that has already boosted innovation within data center networks. In this article, we give a comprehensive overview of use cases for SDN at IXPs, which leverage the superior vantage point of an IXP to introduce advanced features like load balancing and DDoS mitigation. We discuss the benefits of SDN solutions by analyzing real-world data from one of the largest IXPs. We also leverage insights into IXP operations to shape benefits not only for members but also for operators.

Privacy-Preserving Detection of Inter-Domain SDN Rules Overlaps

KAUST Repository

Dethise, Arnaud

2017-08-24

SDN approaches to inter-domain routing promise better traffic engineering, enhanced security, and higher automation. Yet, naïve deployment of SDN on the Internet is dangerous as the control-plane expressiveness of BGP is significantly more limited than the data-plane expressiveness of SDN, which allows fine-grained rules to deflect traffic from BGP\\'s default routes. This mismatch may lead to incorrect forwarding behaviors such as forwarding loops and blackholes, ultimately hindering SDN deployment at the inter-domain level. In this work, we make a first step towards verifying the correctness of inter-domain forwarding state with a focus on loop freedom while keeping private the SDN rules, as they comprise confidential routing information. To this end, we design a simple yet powerful primitive that allows two networks to verify whether their SDN rules overlap, i.e., the set of packets matched by these rules is non-empty, without leaking any information about the SDN rules. We propose an efficient implementation of this primitive by using recent advancements in Secure Multi-Party Computation and we then leverage it as the main building block for designing a system that detects Internet-wide forwarding loops among any set of SDN-enabled Internet eXchange Points.

Jahn-teller domains and magnetic domains in Mn2FeO4

NARCIS (Netherlands)

Kub, J.; Brabers, V.A.M.; Novák, P.; Gemperle, R.; Simsova, J.

2000-01-01

Elastic (Jahn–Teller) domains and magnetic domains in the tetragonal spinel Mn2FeO4 were studied using X-ray double-crystal topography, X-ray diffractometry and the colloid-SEM method. The Jahn–Teller domains of the measured samples are tetragonal with the [0 0 1] c-axis alternating perpendicularly

The extended-domain-eigenfunction method for solving elliptic boundary value problems with annular domains

Energy Technology Data Exchange (ETDEWEB)

Aarao, J; Bradshaw-Hajek, B H; Miklavcic, S J; Ward, D A, E-mail: Stan.Miklavcic@unisa.edu.a [School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095 (Australia)

2010-05-07

Standard analytical solutions to elliptic boundary value problems on asymmetric domains are rarely, if ever, obtainable. In this paper, we propose a solution technique wherein we embed the original domain into one with simple boundaries where the classical eigenfunction solution approach can be used. The solution in the larger domain, when restricted to the original domain, is then the solution of the original boundary value problem. We call this the extended-domain-eigenfunction method. To illustrate the method's strength and scope, we apply it to Laplace's equation on an annular-like domain.

Between-Domain Relations of Students’ Academic Emotions and Their Judgments of School Domain Similarity

Directory of Open Access Journals (Sweden)

Thomas eGoetz

2014-10-01

Full Text Available With the aim to deepen our understanding of the between-domain relations of academic emotions, a series of three studies was conducted. We theorized that between-domain relations of trait (i.e., habitual emotions reflected students’ judgments of domain similarities, whereas between-domain relations of state (i.e., momentary emotions did not. This supposition was based on the accessibility model of emotional self-report, according to which individuals’ beliefs tend to strongly impact trait, but not state emotions. The aim of Study 1 (interviews; N = 40; 8th and 11th graders was to gather salient characteristics of academic domains from students’ perspective. In Study 2 (N=1709; 8th and 11th graders the 13 characteristics identified in Study 1 were assessed along with academic emotions in four different domains (mathematics, physics, German, and English using a questionnaire-based trait assessment. With respect to the same domains, state emotions were assessed in Study 3 (N = 121; 8th and 11th graders by employing an experience sampling approach. In line with our initial assumptions, between-domain relations of trait but not state academic emotions reflected between-domain relations of domain characteristics. Implications for research and practice are discussed.

Between-domain relations of students' academic emotions and their judgments of school domain similarity

Science.gov (United States)

Goetz, Thomas; Haag, Ludwig; Lipnevich, Anastasiya A.; Keller, Melanie M.; Frenzel, Anne C.; Collier, Antonie P. M.

2014-01-01

With the aim to deepen our understanding of the between-domain relations of academic emotions, a series of three studies was conducted. We theorized that between-domain relations of trait (i.e., habitual) emotions reflected students' judgments of domain similarities, whereas between-domain relations of state (i.e., momentary) emotions did not. This supposition was based on the accessibility model of emotional self-report, according to which individuals' beliefs tend to strongly impact trait, but not state emotions. The aim of Study 1 (interviews; N = 40; 8th and 11th graders) was to gather salient characteristics of academic domains from students' perspective. In Study 2 (N = 1709; 8th and 11th graders) the 13 characteristics identified in Study 1 were assessed along with academic emotions in four different domains (mathematics, physics, German, and English) using a questionnaire-based trait assessment. With respect to the same domains, state emotions were assessed in Study 3 (N = 121; 8th and 11th graders) by employing an experience sampling approach. In line with our initial assumptions, between-domain relations of trait but not state academic emotions reflected between-domain relations of domain characteristics. Implications for research and practice are discussed. PMID:25374547

Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature.

Science.gov (United States)

Takemura, Kazuhiro; Hanawa-Suetsugu, Kyoko; Suetsugu, Shiro; Kitao, Akio

2017-07-28

The BAR domain superfamily proteins sense or induce curvature in membranes. The inverse-BAR domain (I-BAR) is a BAR domain that forms a straight "zeppelin-shaped" dimer. The mechanisms by which IRSp53 I-BAR binds to and deforms a lipid membrane are investigated here by all-atom molecular dynamics simulation (MD), binding energy analysis, and the effects of mutation experiments on filopodia on HeLa cells. I-BAR adopts a curved structure when crystallized, but adopts a flatter shape in MD. The binding of I-BAR to membrane was stabilized by ~30 salt bridges, consistent with experiments showing that point mutations of the interface residues have little effect on the binding affinity whereas multiple mutations have considerable effect. Salt bridge formation increases the local density of lipids and deforms the membrane into a concave shape. In addition, the point mutations that break key intra-molecular salt bridges within I-BAR reduce the binding affinity; this was confirmed by expressing these mutants in HeLa cells and observing their effects. The results indicate that the stiffness of I-BAR is important for membrane deformation, although I-BAR does not act as a completely rigid template.

Measuring diagnostic and predictive accuracy in disease management: an introduction to receiver operating characteristic (ROC) analysis.

Science.gov (United States)

Linden, Ariel

2006-04-01

Diagnostic or predictive accuracy concerns are common in all phases of a disease management (DM) programme, and ultimately play an influential role in the assessment of programme effectiveness. Areas, such as the identification of diseased patients, predictive modelling of future health status and costs and risk stratification, are just a few of the domains in which assessment of accuracy is beneficial, if not critical. The most commonly used analytical model for this purpose is the standard 2 x 2 table method in which sensitivity and specificity are calculated. However, there are several limitations to this approach, including the reliance on a single defined criterion or cut-off for determining a true-positive result, use of non-standardized measurement instruments and sensitivity to outcome prevalence. This paper introduces the receiver operator characteristic (ROC) analysis as a more appropriate and useful technique for assessing diagnostic and predictive accuracy in DM. Its advantages include; testing accuracy across the entire range of scores and thereby not requiring a predetermined cut-off point, easily examined visual and statistical comparisons across tests or scores, and independence from outcome prevalence. Therefore the implementation of ROC as an evaluation tool should be strongly considered in the various phases of a DM programme.

Expansion of protein domain repeats.

Directory of Open Access Journals (Sweden)

Asa K Björklund

2006-08-01

Full Text Available Many proteins, especially in eukaryotes, contain tandem repeats of several domains from the same family. These repeats have a variety of binding properties and are involved in protein-protein interactions as well as binding to other ligands such as DNA and RNA. The rapid expansion of protein domain repeats is assumed to have evolved through internal tandem duplications. However, the exact mechanisms behind these tandem duplications are not well-understood. Here, we have studied the evolution, function, protein structure, gene structure, and phylogenetic distribution of domain repeats. For this purpose we have assigned Pfam-A domain families to 24 proteomes with more sensitive domain assignments in the repeat regions. These assignments confirmed previous findings that eukaryotes, and in particular vertebrates, contain a much higher fraction of proteins with repeats compared with prokaryotes. The internal sequence similarity in each protein revealed that the domain repeats are often expanded through duplications of several domains at a time, while the duplication of one domain is less common. Many of the repeats appear to have been duplicated in the middle of the repeat region. This is in strong contrast to the evolution of other proteins that mainly works through additions of single domains at either terminus. Further, we found that some domain families show distinct duplication patterns, e.g., nebulin domains have mainly been expanded with a unit of seven domains at a time, while duplications of other domain families involve varying numbers of domains. Finally, no common mechanism for the expansion of all repeats could be detected. We found that the duplication patterns show no dependence on the size of the domains. Further, repeat expansion in some families can possibly be explained by shuffling of exons. However, exon shuffling could not have created all repeats.

Domain decomposition methods for flows in faulted porous media; Methodes de decomposition de domaine pour les ecoulements en milieux poreux failles

Energy Technology Data Exchange (ETDEWEB)

Flauraud, E.

2004-05-01

In this thesis, we are interested in using domain decomposition methods for solving fluid flows in faulted porous media. This study comes within the framework of sedimentary basin modeling which its aim is to predict the presence of possible oil fields in the subsoil. A sedimentary basin is regarded as a heterogeneous porous medium in which fluid flows (water, oil, gas) occur. It is often subdivided into several blocks separated by faults. These faults create discontinuities that have a tremendous effect on the fluid flow in the basin. In this work, we present two approaches to model faults from the mathematical point of view. The first approach consists in considering faults as sub-domains, in the same way as blocks but with their own geological properties. However, because of the very small width of the faults in comparison with the size of the basin, the second and new approach consists in considering faults no longer as sub-domains, but as interfaces between the blocks. A mathematical study of the two models is carried out in order to investigate the existence and the uniqueness of solutions. Then; we are interested in using domain decomposition methods for solving the previous models. The main part of this study is devoted to the design of Robin interface conditions and to the formulation of the interface problem. The Schwarz algorithm can be seen as a Jacobi method for solving the interface problem. In order to speed up the convergence, this problem can be solved by a Krylov type algorithm (BICGSTAB). We discretize the equations with a finite volume scheme, and perform extensive numerical tests to compare the different methods. (author)

The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding.

Science.gov (United States)

Chen, Shugui; Brier, Sébastien; Smithgall, Thomas E; Engen, John R

2007-04-01

The core of the Abelson tyrosine kinase (c-Abl) is structurally similar to Src-family kinases where SH3 and SH2 domains pack against the backside of the kinase domain in the down-regulated conformation. Both kinase families depend upon intramolecular association of SH3 with the linker joining the SH2 and kinase domains for suppression of kinase activity. Hydrogen deuterium exchange (HX) and mass spectrometry (MS) were used to probe intramolecular interaction of the c-Abl SH3 domain with the linker in recombinant constructs lacking the kinase domain. Under physiological conditions, the c-Abl SH3 domain undergoes partial unfolding, which is stabilized by ligand binding, providing a unique assay for SH3:linker interaction in solution. Using this approach, we observed dynamic association of the SH3 domain with the linker in the absence of the kinase domain. Truncation of the linker before W254 completely prevented cis-interaction with SH3, while constructs containing amino acids past this point showed SH3:linker interactions. The observation that the Abl linker sequence exhibits SH3-binding activity in the absence of the kinase domain is unique to Abl and was not observed with Src-family kinases. These results suggest that SH3:linker interactions may have a more prominent role in Abl regulation than in Src kinases, where the down-regulated conformation is further stabilized by a second intramolecular interaction between the C-terminal tail and the SH2 domain.

Computing fixed points of nonexpansive mappings by $\\alpha$-dense curves

Directory of Open Access Journals (Sweden)

G. García

2017-08-01

Full Text Available Given a multivalued nonexpansive mapping defined on a convex and compact set of a Banach space, with values in the class of convex and compact subsets of its domain, we present an iteration scheme which (under suitable conditions converges to a fixed point of such mapping. This new iteration provides us another method to approximate the fixed points of a singlevalued nonexpansive mapping, defined on a compact and convex set into itself. Moreover, the conditions for the singlevalued case are less restrictive than for the multivalued case. Our main tool will be the so called $\\alpha$-dense curves, which will allow us to construct such iterations. Some numerical examples are provided to illustrate our results.

Molecular dynamics simulations of site point mutations in the TPR domain of cyclophilin 40 identify conformational states with distinct dynamic and enzymatic properties

Science.gov (United States)

Gur, Mert; Blackburn, Elizabeth A.; Ning, Jia; Narayan, Vikram; Ball, Kathryn L.; Walkinshaw, Malcolm D.; Erman, Burak

2018-04-01

Cyclophilin 40 (Cyp40) is a member of the immunophilin family that acts as a peptidyl-prolyl-isomerase enzyme and binds to the heat shock protein 90 (Hsp90). Its structure comprises an N-terminal cyclophilin domain and a C-terminal tetratricopeptide (TPR) domain. Cyp40 is overexpressed in prostate cancer and certain T-cell lymphomas. The groove for Hsp90 binding on the TPR domain includes residues Lys227 and Lys308, referred to as the carboxylate clamp, and is essential for Cyp40-Hsp90 binding. In this study, the effect of two mutations, K227A and K308A, and their combinative mutant was investigated by performing a total of 5.76 μs of all-atom molecular dynamics (MD) simulations in explicit solvent. All simulations, except the K308A mutant, were found to adopt two distinct (extended or compact) conformers defined by different cyclophilin-TPR interdomain distances. The K308A mutant was only observed in the extended form which is observed in the Cyp40 X-ray structure. The wild-type, K227A, and combined mutant also showed bimodal distributions. The experimental melting temperature, Tm, values of the mutants correlate with the degree of compactness with the K308A extended mutant having a marginally lower melting temperature. Another novel measure of compactness determined from the MD data, the "coordination shell volume," also shows a direct correlation with Tm. In addition, the MD simulations show an allosteric effect with the mutations in the remote TPR domain having a pronounced effect on the molecular motions of the enzymatic cyclophilin domain which helps rationalise the experimentally observed increase in enzyme activity measured for all three mutations.

Interoperable domain models : The ISO land administration domain model LADM and its external classes

NARCIS (Netherlands)

Lemmen, C.H.J.; Van Oosterom, P.J.M.; Uitermark, H.T.; Zevenbergen, J.A.; Cooper, A.K.

2011-01-01

This paper provides a brief overview of one of the first spatial domain standards: a standard for the domain of Land Administration (LA). This standard is in the draft stage of development now (May 2011). The development of domain standards is a logical follow up after domain-independent standards,

Changes in cognitive domains during three years in patients with Alzheimer's disease treated with donepezil

Directory of Open Access Journals (Sweden)

Levander Sten

2009-02-01

Full Text Available Abstract Background The objective was to identify separate cognitive domains in the standard assessment tools (MMSE, ADAS-Cog and analyze the process of decline within domains during three years in Alzheimer's disease (AD patients with donepezil treatment. Method AD patients (n = 421 were recruited from a clinical multi-centre study program in Sweden. Patients were assessed every six months during three years. All patients received donepezil starting directly after study entry. After dropouts, 158 patients remained for analyses over three years. Data for the other patients were analysed until they dropped out (4 groups based on length in study. Results Factor analyses of all items suggested that there were three intercorrelated factors: a General, a Memory and a Spatial factor for which we constructed corresponding domains. Overall there was a cognitive improvement at six months followed by a linear drop over time for the three domains. Some group and domain differences were identified. Patients who remained longer in the study had better initial performance and a slower deterioration rate. The early dropouts showed no improvement at six months and many dropped out due to side effects. The other groups displayed a performance improvement at six months that was less pronounced in the Memory domain. Before dropping out, deterioration accelerated, particularly in the Spatial domain. Conclusion The course of illness in the three domains was heterogeneous among the patients. We were not able to identify any clinically relevant correlates of this heterogeneity. As an aid we constructed three algorithms corresponding to the cognitive domains, which can be used to characterize patients initially, identify rapid decliners and follow the course of the disease.

Validation of the facial dysfunction domain of the Penn Acoustic Neuroma Quality-of-Life (PANQOL) Scale.

Science.gov (United States)

Lodder, Wouter L; Adan, Guleed H; Chean, Chung S; Lesser, Tristram H; Leong, Samuel C

2017-06-01

The objective of this study is to evaluate the strength of content validity within the facial dysfunction domain of the Penn Acoustic Neuroma Quality-of-Life (PANQOL) Scale and to compare how it correlates with a facial dysfunction-specific QOL instrument (Facial Clinimetric Evaluation, FaCE). The study design is online questionnaire survey. Members of the British Acoustic Neuroma Association received both PANQOL questionnaires and the FaCE scale. 158 respondents with self-identified facial paralysis or dysfunction had completed PANQOL and FaCE data sets for analysis. The mean composite PANQOL score was 53.5 (range 19.2-93.5), whilst the mean total FaCE score was 50.9 (range 10-95). The total scores of the PANQOL and FaCE correlated moderate (r = 0.48). Strong correlation (r = 0.63) was observed between the PANQOL's facial dysfunction domain and the FaCE total score. Of all the FaCE domains, social function was strongly correlated with the PANQOL facial dysfunction domain (r = 0.66), whilst there was very weak-to-moderate correlation (range 0.01-0.43) to the other FaCE domains. The current study has demonstrated a strong correlation between the facial dysfunction domains of PANQOL with a facial paralysis-specific QOL instrument.

Workflow for near-surface velocity automatic estimation: Source-domain full-traveltime inversion followed by waveform inversion

KAUST Repository

Liu, Lu

2017-08-17

This paper presents a workflow for near-surface velocity automatic estimation using the early arrivals of seismic data. This workflow comprises two methods, source-domain full traveltime inversion (FTI) and early-arrival waveform inversion. Source-domain FTI is capable of automatically generating a background velocity that can kinematically match the reconstructed plane-wave sources of early arrivals with true plane-wave sources. This method does not require picking first arrivals for inversion, which is one of the most challenging aspects of ray-based first-arrival tomographic inversion. Moreover, compared with conventional Born-based methods, source-domain FTI can distinguish between slower or faster initial model errors via providing the correct sign of the model gradient. In addition, this method does not need estimation of the source wavelet, which is a requirement for receiver-domain wave-equation velocity inversion. The model derived from source-domain FTI is then used as input to early-arrival waveform inversion to obtain the short-wavelength velocity components. We have tested the workflow on synthetic and field seismic data sets. The results show source-domain FTI can generate reasonable background velocities for early-arrival waveform inversion even when subsurface velocity reversals are present and the workflow can produce a high-resolution near-surface velocity model.

Leveraging the Domain of Work to Improve Migrant Health.

Science.gov (United States)

Flynn, Michael A; Wickramage, Kolitha

2017-10-19

Work is a principal driver of current international migration, a primary social determinant of health, and a fundamental point of articulation between migrants and their host society. Efforts by international organizations to promote migrant health have traditionally focused on infectious diseases and access to healthcare, while international labor organizations have largely focused on issues of occupational health. The underutilization of the domain of work in addressing the health of migrants is truly a missed opportunity for influencing worker well-being and reducing societal economic burden. Understanding of the relationships among migration, work, and health would facilitate further integration of migrant health concerns into the policy agenda of governments and international agencies that work at the nexus of labor, health and development. The domain of work offers an opportunity to capitalize on the existing health and development infrastructure and leverage technical resources, programs and research to promote migrant health. It also provides the opportunity to advance migrant health through new and innovative approaches and partnerships.

Green's Kernels and meso-scale approximations in perforated domains

CERN Document Server

Maz'ya, Vladimir; Nieves, Michael

2013-01-01

There are a wide range of applications in physics and structural mechanics involving domains with singular perturbations of the boundary. Examples include perforated domains and bodies with defects of different types. The accurate direct numerical treatment of such problems remains a challenge. Asymptotic approximations offer an alternative, efficient solution. Green’s function is considered here as the main object of study rather than a tool for generating solutions of specific boundary value problems. The uniformity of the asymptotic approximations is the principal point of attention. We also show substantial links between Green’s functions and solutions of boundary value problems for meso-scale structures. Such systems involve a large number of small inclusions, so that a small parameter, the relative size of an inclusion, may compete with a large parameter, represented as an overall number of inclusions. The main focus of the present text is on two topics: (a) asymptotics of Green’s kernels in domai...

Domains of Daily Physical Activity in Children with Mitochondrial Disease: A 3D Accelerometry Approach

NARCIS (Netherlands)

Koene, S.; Dirks, I.; Mierlo, E. van; Vries, P.R. de; Janssen, A.J.W.M.; Smeitink, J.; Bergsma, A.; Essers, H.; Meijer, K.; Groot, I.J.M. de

2017-01-01

Feasible, sensitive and clinically relevant outcome measures are of extreme importance when designing clinical trials. For paediatric mitochondrial disease, no robust end point has been described to date. The aim of this study was to select the domains of daily physical activity, which can be

Time-Domain Diversity in Ultra-Wideband MIMO Communications

Directory of Open Access Journals (Sweden)

Alain Sibille

2005-03-01

Full Text Available The development of ultra-wideband (UWB communications is impeded by the drastic transmitted power limitations imposed by regulation authorities due to the “polluting” character of these radio emissions with respect to existing services. Technical solutions must be researched in order either to limit the level of spectral pollution by UWB devices or to increase their reception sensitivity. In the present work, we consider pulse-based modulations and investigate time-domain multiple-input multiple-output (MIMO diversity as one such possible solution. The basic principles of time-domain diversity in the extreme (low multipath density or intermediate (dense multipath UWB regimes are addressed, which predict the possibility of a MIMO gain equal to the product Nt×Nr of the numbers of transmit/receive antenna elements when the channel is not too severe. This analysis is confirmed by simulations using a parametric empirical stochastic double-directional channel model. They confirm the potential interest of MIMO approaches solutions in order to bring a valuable performance gain in UWB communications.

Fixed point of the parabolic renormalization operator

CERN Document Server

Lanford III, Oscar E

2014-01-01

This monograph grew out of the authors' efforts to provide a natural geometric description for the class of maps invariant under parabolic renormalization and for the Inou-Shishikura fixed point itself as well as to carry out a computer-assisted study of the parabolic renormalization operator. It introduces a renormalization-invariant class of analytic maps with a maximal domain of analyticity and rigid covering properties and presents a numerical scheme for computing parabolic renormalization of a germ, which is used to compute the Inou-Shishikura renormalization fixed point.   Inside, readers will find a detailed introduction into the theory of parabolic bifurcation,  Fatou coordinates, Écalle-Voronin conjugacy invariants of parabolic germs, and the definition and basic properties of parabolic renormalization.   The systematic view of parabolic renormalization developed in the book and the numerical approach to its study will be interesting to both experts in the field as well as graduate students wishi...

Comparing Two Approaches for Point-Like Scatterer Detection

Directory of Open Access Journals (Sweden)

Angela Dell’Aversano

2015-01-01

Full Text Available Many inverse scattering problems concern the detection and localisation of point-like scatterers which are sparsely enclosed within a prescribed investigation domain. Therefore, it looks like a good option to tackle the problem by applying reconstruction methods that are properly tailored for such a type of scatterers or that naturally enforce sparsity in the reconstructions. Accordingly, in this paper we compare the time reversal-MUSIC and the compressed sensing. The study develops through numerical examples and focuses on the role of noise in data and mutual coupling between the scatterers.

Domain architecture conservation in orthologs

Science.gov (United States)

2011-01-01

Background As orthologous proteins are expected to retain function more often than other homologs, they are often used for functional annotation transfer between species. However, ortholog identification methods do not take into account changes in domain architecture, which are likely to modify a protein's function. By domain architecture we refer to the sequential arrangement of domains along a protein sequence. To assess the level of domain architecture conservation among orthologs, we carried out a large-scale study of such events between human and 40 other species spanning the entire evolutionary range. We designed a score to measure domain architecture similarity and used it to analyze differences in domain architecture conservation between orthologs and paralogs relative to the conservation of primary sequence. We also statistically characterized the extents of different types of domain swapping events across pairs of orthologs and paralogs. Results The analysis shows that orthologs exhibit greater domain architecture conservation than paralogous homologs, even when differences in average sequence divergence are compensated for, for homologs that have diverged beyond a certain threshold. We interpret this as an indication of a stronger selective pressure on orthologs than paralogs to retain the domain architecture required for the proteins to perform a specific function. In general, orthologs as well as the closest paralogous homologs have very similar domain architectures, even at large evolutionary separation. The most common domain architecture changes observed in both ortholog and paralog pairs involved insertion/deletion of new domains, while domain shuffling and segment duplication/deletion were very infrequent. Conclusions On the whole, our results support the hypothesis that function conservation between orthologs demands higher domain architecture conservation than other types of homologs, relative to primary sequence conservation. This supports the

Effects of sub-domain structure on initial magnetization curve and domain size distribution of stacked media

International Nuclear Information System (INIS)

Sato, S.; Kumagai, S.; Sugita, R.

2015-01-01

In this paper, in order to confirm the sub-domain structure in stacked media demagnetized with in-plane field, initial magnetization curves and magnetic domain size distribution were investigated. Both experimental and simulation results showed that an initial magnetization curve for the medium demagnetized with in-plane field (MDI) initially rose faster than that for the medium demagnetized with perpendicular field (MDP). It is inferred that this is because the MDI has a larger number of domain walls than the MDP due to the existence of the sub-domains, resulting in an increase in the probability of domain wall motion. Dispersion of domain size for the MDI was larger than that for the MDP. This is because sub-domains are formed not only inside the domain but also at the domain boundary region, and they change the position of the domain boundary to affect the domain size. - Highlights: • An initial magnetization curve for MDI initially rose faster than that for MDP. • Dispersion of domain size for the MDI was larger than that for the MDP. • Experimental and simulation results can be explained by existence of sub-domains

THE ROLE OF GHEORGHE POPOVICI IN THE ADMINISTRATION OF SADOVA CROWN DOMAIN (1898-1942

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Narcisa Maria MITU

2016-10-01

Full Text Available For 44 years, Gheorghe Popovici, manged Sadova Crown Domain, a period in which he was preoccupied with the development of Sadova Domain, from all the points of view: organisational, economic and cultural. During the entire period of time, his main purpose was to stop the phenomenon of desertification, by fixing the sand with locust trees and vineyards, in order to make useful as much farm land as possible. So that to successfully accomplish this desire, he gathered around him a collective of young people, chief farmers and sylviculturists, graduates of the higher, prestigious agriculture schools, from Romania and from abroad. He did not neglect either the relations with the villagers, the main manpower from the Domain. For his activity, he was rewarded by the Kings of Romania with plenty of gratitude and honours.

Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation.

Science.gov (United States)

Ayrapetov, Marina K; Nam, Nguyen Hai; Ye, Guofeng; Kumar, Anil; Parang, Keykavous; Sun, Gongqin

2005-07-08

The C-terminal Src kinase (Csk) family of protein tyrosine kinases contains two members: Csk and Csk homologous kinase (Chk). Both phosphorylate and inactivate Src family kinases. Recent reports suggest that the Src homology (SH) 2 domains of Csk and Chk may bind to different phosphoproteins, which provides a basis for different cellular functions for Csk and Chk. To verify and characterize such a functional divergence, we compared the binding properties of the Csk, Chk, and Src SH2 domains and investigated the structural basis for the functional divergence. First, the study demonstrated striking functional differences between the Csk and Chk SH2 domains and revealed functional similarities between the Chk and Src SH2 domains. Second, structural analysis and mutagenic studies revealed that the functional differences among the three SH2 domains were largely controlled by one residue, Glu127 in Csk, Ile167 in Chk, and Lys200 in Src. Mutating these residues in the Csk or Chk SH2 domain to the Src counterpart resulted in dramatic gain of function similar to Src SH2 domain, whereas mutating Lys200 in Src SH2 domain to Glu (the Csk counterpart) resulted in loss of Src SH2 function. Third, a single point mutation of E127K rendered Csk responsive to activation by a Src SH2 domain ligand. Finally, the optimal phosphopeptide sequence for the Chk SH2 domain was determined. These results provide a compelling explanation for the functional differences between two homologous protein tyrosine kinases and reveal a new structure-function relationship for the SH2 domains.

A Review of Domain Modelling and Domain Imaging Techniques in Ferroelectric Crystals

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John E. Huber

2011-02-01

Full Text Available The present paper reviews models of domain structure in ferroelectric crystals, thin films and bulk materials. Common crystal structures in ferroelectric materials are described and the theory of compatible domain patterns is introduced. Applications to multi-rank laminates are presented. Alternative models employing phase-field and related techniques are reviewed. The paper then presents methods of observing ferroelectric domain structure, including optical, polarized light, scanning electron microscopy, X-ray and neutron diffraction, atomic force microscopy and piezo-force microscopy. Use of more than one technique for unambiguous identification of the domain structure is also described.

Establishing meaningful cut points for online user ratings.

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Hirschfeld, Gerrit; Thielsch, Meinald T

2015-01-01

Subjective perceptions of websites can be reliably measured with questionnaires. But it is unclear how such scores should be interpreted in practice, e.g. is an aesthetics score of 4 points on a seven-point-scale satisfactory? The current paper introduces a receiver-operating characteristic (ROC)-based methodology to establish meaningful cut points for the VisAWI (visual aesthetics of websites inventory) and its short form the VisAWI-S. In two studies we use users' global ratings (UGRs) and website rankings as anchors. A total of 972 participants took part in the studies which yielded similar results. First, one-item UGRs correlate highly with the VisAWI. Second, cut points on the VisAWI reliably differentiate between sites that are perceived as attractive versus unattractive. Third, these cut points are variable, but only within a certain range. Together the research presented here establishes a score of 4.5 on the VisAWI which is a reasonable goal for website designers and highlights the utility of the ROC methodology to derive relevant scores for rating scales.

Glaucoma diagnosis by mapping macula with Fourier domain optical coherence tomography

Science.gov (United States)

Tan, Ou; Lu, Ake; Chopra, Vik; Varma, Rohit; Hiroshi, Ishikawa; Schuman, Joel; Huang, David

2008-03-01

A new image segmentation method was developed to detect macular retinal sub-layers boundary on newly-developed Fourier-Domain Optical Coherence Tomography (FD-OCT) with macular grid scan pattern. The segmentation results were used to create thickness map of macular ganglion cell complex (GCC), which contains the ganglion cell dendrites, cell bodies and axons. Overall average and several pattern analysis parameters were defined on the GCC thickness map and compared for the diagnosis of glaucoma. Intraclass correlation (ICC) is used to compare the reproducibility of the parameters. Area under receiving operative characteristic curve (AROC) was calculated to compare the diagnostic power. The result is also compared to the output of clinical time-domain OCT (TD-OCT). We found that GCC based parameters had good repeatability and comparable diagnostic power with circumpapillary nerve fiber layer (cpNFL) thickness. Parameters based on pattern analysis can increase the diagnostic power of GCC macular mapping.

The retinal specific CD147 Ig0 domain: from molecular structure to biological activity

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Redzic, Jasmina S.; Armstrong, Geoffrey S.; Isern, Nancy. G.; Jones, David N.M.; Kieft, Jeffrey S.; Eisenmesser, Elan Zohar

2011-01-01

CD147 is a type I transmembrane protein that is involved in inflammatory diseases, cancer progression, and multiple human pathogens utilize CD147 for efficient infection. In several cancers, CD147 expression is so high that it is now used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified, differing in their number of immunoglobulin (Ig)-like domains. These include CD147 Ig1-Ig2 that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 that is retinal specific and implicated in retinoblastoma. However, little is known in regard to the retinal specific CD147 Ig0 domain despite its potential role in retinoblastoma. We present the first crystal structure of the human CD147 Ig0 domain and show that the CD147 Ig0 domain is a crystallographic dimer with an I-type domain structure, which is maintained in solution. Furthermore, we have utilized our structural data together with mutagenesis to probe the biological activity of CD147-containing proteins both with and without the CD147 Ig0 domain within several model cell lines. Our findings reveal that the CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 domain has its own receptor distinct from that of the other CD147 Ig-like domains, CD147 Ig1-Ig2. Finally, we show that the CD147 Ig0 dimer is the functional unit required for activity and can be disrupted by a single point mutation. PMID:21620857

Zidovudine (AZT monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase.

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Jessica H Brehm

Full Text Available We previously demonstrated in vitro that zidovudine (AZT selects for A371V in the connection domain and Q509L in ribonuclease H (RNase H domain of HIV-1 reverse transcriptase (RT which, together with the thymidine analog mutations D67N, K70R and T215F, confer greater than 100-fold AZT resistance. The goal of the current study was to determine whether AZT monotherapy in HIV-1 infected patients also selects the A371V, Q509L or other mutations in the C-terminal domains of HIV-1 RT.Full-length RT sequences in plasma obtained pre- and post-therapy were compared in 23 participants who received AZT monotherapy from the AIDS Clinical Trials Group study 175. Five of the 23 participants reached a primary study endpoint. Mutations significantly associated with AZT monotherapy included K70R (p = 0.003 and T215Y (p = 0.013 in the polymerase domain of HIV-1 RT, and A360V (p = 0.041 in the connection domain of HIV-1 RT. HIV-1 drug susceptibility assays demonstrated that A360V, either alone or in combination with thymidine analog mutations, decreased AZT susceptibility in recombinant viruses containing participant-derived full-length RT sequences or site-directed mutant RT. Biochemical studies revealed that A360V enhances the AZT-monophosphate excision activity of purified RT by significantly decreasing the frequency of secondary RNase H cleavage events that reduce the RNA/DNA duplex length and promote template/primer dissociation.The A360V mutation in the connection domain of RT was selected in HIV-infected individuals that received AZT monotherapy and contributed to AZT resistance.

Experimental Evaluation of the "Polished Panel Optical Receiver" Concept on the Deep Space Network's 34 Meter Antenna

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Vilnrotter, Victor A.

2012-01-01

The potential development of large aperture ground-based "photon bucket" optical receivers for deep space communications has received considerable attention recently. One approach currently under investigation proposes to polish the aluminum reflector panels of 34-meter microwave antennas to high reflectance, and accept the relatively large spotsize generated by even state-of-the-art polished aluminum panels. Here we describe the experimental effort currently underway at the Deep Space Network (DSN) Goldstone Communications Complex in California, to test and verify these concepts in a realistic operational environment. A custom designed aluminum panel has been mounted on the 34 meter research antenna at Deep-Space Station 13 (DSS-13), and a remotely controlled CCD camera with a large CCD sensor in a weather-proof container has been installed next to the subreflector, pointed directly at the custom polished panel. Using the planet Jupiter as the optical point-source, the point-spread function (PSF) generated by the polished panel has been characterized, the array data processed to determine the center of the intensity distribution, and expected communications performance of the proposed polished panel optical receiver has been evaluated.

Chemical Shift Assignments of the C-terminal Eps15 Homology Domain-3 EH Domain*

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Caplan, Steve; Sorgen, Paul L.

2013-01-01

The C-terminal Eps15 homology (EH) domain 3 (EHD3) belongs to a eukaryotic family of endocytic regulatory proteins and is involved in the recycling of various receptors from the early endosome to the endocytic recycling compartment or in retrograde transport from the endosomes to the Golgi. EH domains are highly conserved in the EHD family and function as protein-protein interaction units that bind to Asn-Pro-Phe (NPF) motif-containing proteins. The EH domain of EHD1 was the first C-terminal EH domain from the EHD family to be solved by NMR. The differences observed between this domain and proteins with N-terminal EH domains helped describe a mechanism for the differential binding of NPF-containing proteins. Here, structural studies were expanded to include the EHD3 EH domain. While the EHD1 and EHD3 EH domains are highly homologous, they have different protein partners. A comparison of these structures will help determine the selectivity in protein binding between the EHD family members and lead to a better understanding of their unique roles in endocytic regulation. PMID:23754701

Simplicity and Specificity in Language: Domain-General Biases Have Domain-Specific Effects

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Culbertson, Jennifer; Kirby, Simon

2016-01-01

The extent to which the linguistic system—its architecture, the representations it operates on, the constraints it is subject to—is specific to language has broad implications for cognitive science and its relation to evolutionary biology. Importantly, a given property of the linguistic system can be “specific” to the domain of language in several ways. For example, if the property evolved by natural selection under the pressure of the linguistic function it serves then the property is domain-specific in the sense that its design is tailored for language. Equally though, if that property evolved to serve a different function or if that property is domain-general, it may nevertheless interact with the linguistic system in a way that is unique. This gives a second sense in which a property can be thought of as specific to language. An evolutionary approach to the language faculty might at first blush appear to favor domain-specificity in the first sense, with individual properties of the language faculty being specifically linguistic adaptations. However, we argue that interactions between learning, culture, and biological evolution mean any domain-specific adaptations that evolve will take the form of weak biases rather than hard constraints. Turning to the latter sense of domain-specificity, we highlight a very general bias, simplicity, which operates widely in cognition and yet interacts with linguistic representations in domain-specific ways. PMID:26793132

Kinase impact assessment in the landscape of fusion genes that retain kinase domains: a pan-cancer study

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Kim, Pora; Jia, Peilin; Zhao, Zhongming

2018-01-01

Abstract Assessing the impact of kinase in gene fusion is essential for both identifying driver fusion genes (FGs) and developing molecular targeted therapies. Kinase domain retention is a crucial factor in kinase fusion genes (KFGs), but such a systematic investigation has not been done yet. To this end, we analyzed kinase domain retention (KDR) status in chimeric protein sequences of 914 KFGs covering 312 kinases across 13 major cancer types. Based on 171 kinase domain-retained KFGs including 101 kinases, we studied their recurrence, kinase groups, fusion partners, exon-based expression depth, short DNA motifs around the break points and networks. Our results, such as more KDR than 5′-kinase fusion genes, combinatorial effects between 3′-KDR kinases and their 5′-partners and a signal transduction-specific DNA sequence motif in the break point intronic sequences, supported positive selection on 3′-kinase fusion genes in cancer. We introduced a degree-of-frequency (DoF) score to measure the possible number of KFGs of a kinase. Interestingly, kinases with high DoF scores tended to undergo strong gene expression alteration at the break points. Furthermore, our KDR gene fusion network analysis revealed six of the seven kinases with the highest DoF scores (ALK, BRAF, MET, NTRK1, NTRK3 and RET) were all observed in thyroid carcinoma. Finally, we summarized common features of ‘effective’ (highly recurrent) kinases in gene fusions such as expression alteration at break point, redundant usage in multiple cancer types and 3′-location tendency. Collectively, our findings are useful for prioritizing driver kinases and FGs and provided insights into KFGs’ clinical implications. PMID:28013235

Multiple functions of the von Willebrand Factor A domain in matrilins: secretion, assembly, and proteolysis

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Kanbe Katsuaki

2008-06-01

Full Text Available Abstract The von Willebrand Factor A (vWF A domain is one of the most widely distributed structural modules in cell-matrix adhesive molecules such as intergrins and extracellular matrix proteins. Mutations in the vWF A domain of matrilin-3 cause multiple epiphyseal dysplasia (MED, however the pathological mechanism remains to be determined. Previously we showed that the vWF A domain in matrilin-1 mediates formation of a filamentous matrix network through metal-ion dependent adhesion sites in the domain. Here we show two new functions of the vWF A domain in cartilage-specific matrilins (1 and 3. First, vWF A domain regulates oligomerization of matrilins. Insertion of a vWF A domain into matrilin-3 converts the formation of a mixture of matrilin-3 tetramer, trimer, and dimer into a tetramer only, while deletion of a vWF A domain from matrilin-1 converts the formation of the native matrilin-1 trimer into a mixture of trimer and dimer. Second, the vWF A domain protects matrilin-1 from proteolysis. We identified a latent proteolytic site next to the vWF A2 domain in matrilin-1, which is sensitive to the inhibitors of matrix proteases. Deletion of the abutting vWF A domain results in degradation of matrilin-1, presumably by exposing the adjacent proteolytic site. In addition, we also confirmed the vWF A domain is vital for the secretion of matrilin-3. Secretion of the mutant matrilin-3 harbouring a point mutation within the vWF A domain, as occurred in MED patients, is markedly reduced and delayed, resulting from intracellular retention of the mutant matrilin-3. Taken together, our data suggest that different mutations/deletions of the vWF A domain in matrilins may lead to distinct pathological mechanisms due to the multiple functions of the vWF A domain.

Method of Check of Statistical Hypotheses for Revealing of “Fraud” Point of Sale

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T. M. Bolotskaya

2011-06-01

Full Text Available Application method checking of statistical hypotheses fraud Point of Sale working with purchasing cards and suspected of accomplishment of unauthorized operations is analyzed. On the basis of the received results the algorithm is developed, allowing receive an assessment of works of terminals in regime off-line.

Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy.

Science.gov (United States)

Kawara, Fumiaki; Fujita, Tsuyoshi; Morita, Yoshinori; Uda, Atsushi; Masuda, Atsuhiro; Saito, Masaya; Ooi, Makoto; Ishida, Tsukasa; Kondo, Yasuyuki; Yoshida, Shiei; Okuno, Tatsuya; Yano, Yoshihiko; Yoshida, Masaru; Kutsumi, Hiromu; Hayakumo, Takanobu; Yamashita, Kazuhiko; Hirano, Takeshi; Hirai, Midori; Azuma, Takeshi

2017-03-21

To elucidate the factors associated with residual gastroesophageal reflux disease (GERD) symptoms in patients receiving proton pump inhibitor (PPI) maintenance therapy in clinical practice. The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD (FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale (GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were analyzed. The FSSG scores ranged from 1 to 28 points (median score: 7.5 points), and 19 patients (48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores (correlation coefficient = 0.47, P reflux-related symptom scores: 12 ± 1.9 vs 2.5 ± 0.8, P reflux disease patients were significantly lower than those of the other patients (total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P < 0.05; dysmotility symptom-related scores: 1.0 ± 0.4 vs 6.0 ± 0.8, P < 0.01). Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms.

Seismic response of three-dimensional topographies using a time-domain boundary element method

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Janod, François; Coutant, Olivier

2000-08-01

We present a time-domain implementation for a boundary element method (BEM) to compute the diffraction of seismic waves by 3-D topographies overlying a homogeneous half-space. This implementation is chosen to overcome the memory limitations arising when solving the boundary conditions with a frequency-domain approach. This formulation is flexible because it allows one to make an adaptive use of the Green's function time translation properties: the boundary conditions solving scheme can be chosen as a trade-off between memory and cpu requirements. We explore here an explicit method of solution that requires little memory but a high cpu cost in order to run on a workstation computer. We obtain good results with four points per minimum wavelength discretization for various topographies and plane wave excitations. This implementation can be used for two different aims: the time-domain approach allows an easier implementation of the BEM in hybrid methods (e.g. coupling with finite differences), and it also allows one to run simple BEM models with reasonable computer requirements. In order to keep reasonable computation times, we do not introduce any interface and we only consider homogeneous models. Results are shown for different configurations: an explosion near a flat free surface, a plane wave vertically incident on a Gaussian hill and on a hemispherical cavity, and an explosion point below the surface of a Gaussian hill. Comparison is made with other numerical methods, such as finite difference methods (FDMs) and spectral elements.

The framing of scientific domains

DEFF Research Database (Denmark)

Dam Christensen, Hans

2014-01-01

domains, and UNISIST helps understanding this navigation. Design/methodology/approach The UNISIST models are tentatively applied to the domain of art history at three stages, respectively two modern, partially overlapping domains, as well as an outline of an art historical domain anno c1820...

Protein domain organisation: adding order.

Science.gov (United States)

Kummerfeld, Sarah K; Teichmann, Sarah A

2009-01-29

Domains are the building blocks of proteins. During evolution, they have been duplicated, fused and recombined, to produce proteins with novel structures and functions. Structural and genome-scale studies have shown that pairs or groups of domains observed together in a protein are almost always found in only one N to C terminal order and are the result of a single recombination event that has been propagated by duplication of the multi-domain unit. Previous studies of domain organisation have used graph theory to represent the co-occurrence of domains within proteins. We build on this approach by adding directionality to the graphs and connecting nodes based on their relative order in the protein. Most of the time, the linear order of domains is conserved. However, using the directed graph representation we have identified non-linear features of domain organization that are over-represented in genomes. Recognising these patterns and unravelling how they have arisen may allow us to understand the functional relationships between domains and understand how the protein repertoire has evolved. We identify groups of domains that are not linearly conserved, but instead have been shuffled during evolution so that they occur in multiple different orders. We consider 192 genomes across all three kingdoms of life and use domain and protein annotation to understand their functional significance. To identify these features and assess their statistical significance, we represent the linear order of domains in proteins as a directed graph and apply graph theoretical methods. We describe two higher-order patterns of domain organisation: clusters and bi-directionally associated domain pairs and explore their functional importance and phylogenetic conservation. Taking into account the order of domains, we have derived a novel picture of global protein organization. We found that all genomes have a higher than expected degree of clustering and more domain pairs in forward and

Protein domain organisation: adding order

Directory of Open Access Journals (Sweden)

Kummerfeld Sarah K

2009-01-01

Full Text Available Abstract Background Domains are the building blocks of proteins. During evolution, they have been duplicated, fused and recombined, to produce proteins with novel structures and functions. Structural and genome-scale studies have shown that pairs or groups of domains observed together in a protein are almost always found in only one N to C terminal order and are the result of a single recombination event that has been propagated by duplication of the multi-domain unit. Previous studies of domain organisation have used graph theory to represent the co-occurrence of domains within proteins. We build on this approach by adding directionality to the graphs and connecting nodes based on their relative order in the protein. Most of the time, the linear order of domains is conserved. However, using the directed graph representation we have identified non-linear features of domain organization that are over-represented in genomes. Recognising these patterns and unravelling how they have arisen may allow us to understand the functional relationships between domains and understand how the protein repertoire has evolved. Results We identify groups of domains that are not linearly conserved, but instead have been shuffled during evolution so that they occur in multiple different orders. We consider 192 genomes across all three kingdoms of life and use domain and protein annotation to understand their functional significance. To identify these features and assess their statistical significance, we represent the linear order of domains in proteins as a directed graph and apply graph theoretical methods. We describe two higher-order patterns of domain organisation: clusters and bi-directionally associated domain pairs and explore their functional importance and phylogenetic conservation. Conclusion Taking into account the order of domains, we have derived a novel picture of global protein organization. We found that all genomes have a higher than expected

Algebraic and analyticity properties of the n-point function in quantum field theory

International Nuclear Information System (INIS)

Bros, Jacques

1970-01-01

The general theory of quantized fields (axiomatic approach) is investigated. A systematic study of the algebraic properties of all the Green functions of a local field, which generalize the ordinary retarded and advanced functions, is presented. The notion emerges of a primitive analyticity domain of the n-point function, and of the existence of auxiliary analytic functions into which the various Green functions can be decomposed. Certain processes of analytic completion are described, and then applied to enlarging the primitive domain, particularly for the case n = 4; among the results the crossing property for all scattering amplitudes which involve two incoming and two outgoing particles is proved. (author) [fr

Ultra-low-power and ultra-low-cost short-range wireless receivers in nanoscale CMOS

CERN Document Server

Lin, Zhicheng; Martins, Rui Paulo

2016-01-01

This book provides readers with a description of state-of-the-art techniques to be used for ultra-low-power (ULP) and ultra-low-cost (ULC), short-range wireless receivers. Readers will learn what is required to deploy these receivers in short-range wireless sensor networks, which are proliferating widely to serve the internet of things (IoT) for “smart cities.” The authors address key challenges involved with the technology and the typical tradeoffs between ULP and ULC. Three design examples with advanced circuit techniques are described in order to address these trade-offs, which specially focus on cost minimization. These three techniques enable respectively, cascading of radio frequency (RF) and baseband (BB) circuits under an ultra-low-voltage (ULV) supply, cascoding of RF and BB circuits in current domain for current reuse, and a novel function-reuse receiver architecture, suitable for ULV and multi-band ULP applications such as the sub-GHz ZigBee. ·         Summarizes the state-of-the-art i...

Insights into function of PSI domains from structure of the Met receptor PSI domain

International Nuclear Information System (INIS)

Kozlov, Guennadi; Perreault, Audrey; Schrag, Joseph D.; Park, Morag; Cygler, Miroslaw; Gehring, Kalle; Ekiel, Irena

2004-01-01

PSI domains are cysteine-rich modules found in extracellular fragments of hundreds of signaling proteins, including plexins, semaphorins, integrins, and attractins. Here, we report the solution structure of the PSI domain from the human Met receptor, a receptor tyrosine kinase critical for proliferation, motility, and differentiation. The structure represents a cysteine knot with short regions of secondary structure including a three-stranded antiparallel β-sheet and two α-helices. All eight cysteines are involved in disulfide bonds with the pattern consistent with that for the PSI domain from Sema4D. Comparison with the Sema4D structure identifies a structurally conserved core comprising the N-terminal half of the PSI domain. Interestingly, this part links adjacent SEMA and immunoglobulin domains in the Sema4D structure, suggesting that the PSI domain serves as a wedge between propeller and immunoglobulin domains and is responsible for the correct positioning of the ligand-binding site of the receptor

Site-Directed Mutagenesis of the Fibronectin Domains in Insulin Receptor-Related Receptor

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Igor E. Deyev

2017-11-01

Full Text Available The orphan insulin receptor-related receptor (IRR, in contrast to its close homologs, the insulin receptor (IR and insulin-like growth factor receptor (IGF-IR can be activated by mildly alkaline extracellular medium. We have previously demonstrated that IRR activation is defined by its extracellular region, involves multiple domains, and shows positive cooperativity with two synergistic sites. By the analyses of point mutants and chimeras of IRR with IR in, we now address the role of the fibronectin type III (FnIII repeats in the IRR pH-sensing. The first activation site includes the intrinsically disordered subdomain ID (646–716 within the FnIII-2 domain at the C-terminus of IRR alpha subunit together with closely located residues L135, G188, R244, H318, and K319 of L1 and C domains of the second subunit. The second site involves residue T582 of FnIII-1 domain at the top of IRR lambda-shape pyramid together with M406, V407, and D408 from L2 domain within the second subunit. A possible importance of the IRR carbohydrate moiety for its activation was also assessed. IRR is normally less glycosylated than IR and IGF-IR. Swapping both FnIII-2 and FnIII-3 IRR domains with those of IR shifted beta-subunit mass from 68 kDa for IRR to about 100 kDa due to increased glycosylation and abolished the IRR pH response. However, mutations of four asparagine residues, potential glycosylation sites in chimera IRR with swapped FnIII-2/3 domains of IR, decreased the chimera glycosylation and resulted in a partial restoration of IRR pH-sensing activity, suggesting that the extensive glycosylation of FnIII-2/3 provides steric hindrance for the alkali-induced rearrangement of the IRR ectodomain.

Measuring cognition in teams: a cross-domain review.

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Wildman, Jessica L; Salas, Eduardo; Scott, Charles P R

2014-08-01

The purpose of this article is twofold: to provide a critical cross-domain evaluation of team cognition measurement options and to provide novice researchers with practical guidance when selecting a measurement method. A vast selection of measurement approaches exist for measuring team cognition constructs including team mental models, transactive memory systems, team situation awareness, strategic consensus, and cognitive processes. Empirical studies and theoretical articles were reviewed to identify all of the existing approaches for measuring team cognition. These approaches were evaluated based on theoretical perspective assumed, constructs studied, resources required, level of obtrusiveness, internal consistency reliability, and predictive validity. The evaluations suggest that all existing methods are viable options from the point of view of reliability and validity, and that there are potential opportunities for cross-domain use. For example, methods traditionally used only to measure mental models may be useful for examining transactive memory and situation awareness. The selection of team cognition measures requires researchers to answer several key questions regarding the theoretical nature of team cognition and the practical feasibility of each method. We provide novice researchers with guidance regarding how to begin the search for a team cognition measure and suggest several new ideas regarding future measurement research. We provide (1) a broad overview and evaluation of existing team cognition measurement methods, (2) suggestions for new uses of those methods across research domains, and (3) critical guidance for novice researchers looking to measure team cognition.

Delayed Recall and Working Memory MMSE Domains Predict Delirium following Cardiac Surgery.

Science.gov (United States)

Price, Catherine C; Garvan, Cynthia; Hizel, Loren P; Lopez, Marcos G; Billings, Frederic T

2017-01-01

Reduced preoperative cognition is a risk factor for postoperative delirium. The significance for type of preoperative cognitive deficit, however, has yet to be explored and could provide important insights into mechanisms and prediction of delirium. Our goal was to determine if certain cognitive domains from the general cognitive screener, the Mini-Mental State Exam (MMSE), predict delirium after cardiac surgery. Patients completed a preoperative MMSE prior to undergoing elective cardiac surgery. Following surgery, delirium was assessed throughout ICU stay using the Confusion Assessment Method for ICU delirium and the Richmond Agitation and Sedation Scale. Cardiac surgery patients who developed delirium (n = 137) had lower total MMSE scores than patients who did not develop delirium (n = 457). In particular, orientation to place, working memory, delayed recall, and language domain scores were lower. Of these, only the working memory and delayed recall domains predicted delirium in a regression model adjusting for history of chronic obstructive pulmonary disease, age, sex, and duration of cardiopulmonary bypass. For each word not recalled on the three-word delayed recall assessment, the odds of delirium increased by 50%. For each item missed on the working memory index, the odds of delirium increased by 36%. Of the patients who developed delirium, 47% had a primary impairment in memory, 21% in working memory, and 33% in both domains. The area under the receiver operating characteristics curve using only the working memory and delayed recall domains was 0.75, compared to 0.76 for total MMSE score. Delirium risk is greater for individuals with reduced MMSE scores on the delayed recall and working memory domains. Research should address why patients with memory and executive vulnerabilities are more prone to postoperative delirium than those with other cognitive limitations.

Time evolution of one-dimensional gapless models from a domain wall initial state: stochastic Loewner evolution continued?

International Nuclear Information System (INIS)

Calabrese, Pasquale; Hagendorf, Christian; Doussal, Pierre Le

2008-01-01

We study the time evolution of quantum one-dimensional gapless systems evolving from initial states with a domain wall. We generalize the path integral imaginary time approach that together with boundary conformal field theory allows us to derive the time and space dependence of general correlation functions. The latter are explicitly obtained for the Ising universality class, and the typical behavior of one- and two-point functions is derived for the general case. Possible connections with the stochastic Loewner evolution are discussed and explicit results for one-point time dependent averages are obtained for generic κ for boundary conditions corresponding to stochastic Loewner evolution. We use this set of results to predict the time evolution of the entanglement entropy and obtain the universal constant shift due to the presence of a domain wall in the initial state

Layered and Laterally Constrained 2D Inversion of Time Domain Induced Polarization Data

DEFF Research Database (Denmark)

Fiandaca, Gianluca; Ramm, James; Auken, Esben

description of the transmitter waveform and of the receiver transfer function allowing for a quantitative interpretation of the parameters. The code has been optimized for parallel computation and the inversion time is comparable to codes inverting just for direct current resistivity. The new inversion......In a sedimentary environment, quasi-layered models often represent the actual geology more accurately than smooth minimum-structure models. We have developed a new layered and laterally constrained inversion algorithm for time domain induced polarization data. The algorithm is based on the time...... transform of a complex resistivity forward response and the inversion extracts the spectral information of the time domain measures in terms of the Cole-Cole parameters. The developed forward code and inversion algorithm use the full time decay of the induced polarization response, together with an accurate...

Towards a minimal generic set of domains of functioning and health.

Science.gov (United States)

Cieza, Alarcos; Oberhauser, Cornelia; Bickenbach, Jerome; Chatterji, Somnath; Stucki, Gerold

2014-03-03

The World Health Organization (WHO) has argued that functioning, and, more concretely, functioning domains constitute the operationalization that best captures our intuitive notion of health. Functioning is, therefore, a major public-health goal. A great deal of data about functioning is already available. Nonetheless, it is not possible to compare and optimally utilize this information. One potential approach to address this challenge is to propose a generic and minimal set of functioning domains that captures the experience of individuals and populations with respect to functioning and health. The objective of this investigation was to identify a minimal generic set of ICF domains suitable for describing functioning in adults at both the individual and population levels. We performed a psychometric study using data from: 1) the German National Health Interview and Examination Survey 1998, 2) the United States National Health and Nutrition Examination Survey 2007/2008, and 3) the ICF Core Set studies. Random Forests and Group Lasso regression were applied using one self-reported general-health question as a dependent variable. The domains selected were compared to those of the World Health Survey (WHS) developed by the WHO. Seven domains of the International Classification of Functioning, Disability and Health (ICF) are proposed as a minimal generic set of functioning and health: energy and drive functions, emotional functions, sensation of pain, carrying out daily routine, walking, moving around, and remunerative employment. The WHS domains of self-care, cognition, interpersonal activities, and vision were not included in our selection. The minimal generic set proposed in this study is the starting point to address one of the most important challenges in health measurement--the comparability of data across studies and countries. It also represents the first step in developing a common metric of health to link information from the general population to information

Electrically continuous graphene from single crystal copper verified by terahertz conductance spectroscopy and micro four-point probe

DEFF Research Database (Denmark)

Buron, Jonas Christian Due; Pizzocchero, Filippo; Jessen, Bjarke Sørensen

2014-01-01

noninvasive conductance characterization methods: ultrabroadband terahertz time-domain spectroscopy and micro four-point probe, which probe the electrical properties of the graphene film on different length scales, 100 nm and 10 μm, respectively. Ultrabroadband terahertz time-domain spectroscopy allows......- and microscale electrical continuity of single layer graphene grown on centimeter-sized single crystal copper with that of previously studied graphene films, grown on commercially available copper foil, after transfer to SiO2 surfaces. The electrical continuity of the graphene films is analyzed using two....... Micro four-point probe resistance values measured on graphene grown on single crystalline copper in two different voltage-current configurations show close agreement with the expected distributions for a continuous 2D conductor, in contrast with previous observations on graphene grown on commercial...

Comparing interpolation schemes in dynamic receive ultrasound beamforming

DEFF Research Database (Denmark)

Kortbek, Jacob; Andresen, Henrik; Nikolov, Svetoslav

2005-01-01

In medical ultrasound interpolation schemes are of- ten applied in receive focusing for reconstruction of image points. This paper investigates the performance of various interpolation scheme by means of ultrasound simulations of point scatterers in Field II. The investigation includes conventional...... B-mode imaging and synthetic aperture (SA) imaging using a 192-element, 7 MHz linear array transducer with λ pitch as simulation model. The evaluation consists primarily of calculations of the side lobe to main lobe ratio, SLMLR, and the noise power of the interpolation error. When using...... conventional B-mode imaging and linear interpolation, the difference in mean SLMLR is 6.2 dB. With polynomial interpolation the ratio is in the range 6.2 dB to 0.3 dB using 2nd to 5th order polynomials, and with FIR interpolation the ratio is in the range 5.8 dB to 0.1 dB depending on the filter design...

Recovering protein-protein and domain-domain interactions from aggregation of IP-MS proteomics of coregulator complexes.

Directory of Open Access Journals (Sweden)

Amin R Mazloom

2011-12-01

Full Text Available Coregulator proteins (CoRegs are part of multi-protein complexes that transiently assemble with transcription factors and chromatin modifiers to regulate gene expression. In this study we analyzed data from 3,290 immuno-precipitations (IP followed by mass spectrometry (MS applied to human cell lines aimed at identifying CoRegs complexes. Using the semi-quantitative spectral counts, we scored binary protein-protein and domain-domain associations with several equations. Unlike previous applications, our methods scored prey-prey protein-protein interactions regardless of the baits used. We also predicted domain-domain interactions underlying predicted protein-protein interactions. The quality of predicted protein-protein and domain-domain interactions was evaluated using known binary interactions from the literature, whereas one protein-protein interaction, between STRN and CTTNBP2NL, was validated experimentally; and one domain-domain interaction, between the HEAT domain of PPP2R1A and the Pkinase domain of STK25, was validated using molecular docking simulations. The scoring schemes presented here recovered known, and predicted many new, complexes, protein-protein, and domain-domain interactions. The networks that resulted from the predictions are provided as a web-based interactive application at http://maayanlab.net/HT-IP-MS-2-PPI-DDI/.

The flow distribution in the parallel tubes of the cavity receiver under variable heat flux

International Nuclear Information System (INIS)

Hao, Yun; Wang, Yueshe; Hu, Tian

2016-01-01

Highlights: • An experimental loop is built to find the flow distribution in the parallel tubes. • With the concentration of heat flux, two-phase flow makes distribution more uneven. • The total flow rate is chosen appropriately for a wider heat flux distribution. • A suitable system pressure is essential for the optimization of flow distribution. - Abstract: As an optical component of tower solar thermal power station, the heliostat mirror reflects sunlight to one point of the heated surface in the solar cavity receiver, called as one-point focusing system. The radiation heat flux concentrated in the cavity receiver is always non-uniform temporally and spatially, which may lead to extremely local over-heat on the receiver evaporation panels. In this paper, an electrical heated evaporating experimental loop, including five parallel vertical tubes, is set up to evaluate the hydrodynamic characteristics of evaporation panels in a solar cavity receiver under various non-uniform heat flux. The influence of the heat flux concentration ratio, total flow rate, and system pressure on the flow distribution of parallel tubes is discussed. It is found that the flow distribution becomes significantly worse with the increase of heat flux and concentration ratio; and as the system pressure decreased, the flow distribution is improved. It is extremely important to obtain these interesting findings for the safe and stable operation of solar cavity receiver, and can also provide valuable references for the design and optimization of operating parameters solar tower power station system.

Full waveform inversion in the frequency domain using classified time-domain residual wavefields

Science.gov (United States)

Son, Woohyun; Koo, Nam-Hyung; Kim, Byoung-Yeop; Lee, Ho-Young; Joo, Yonghwan

2017-04-01

We perform the acoustic full waveform inversion in the frequency domain using residual wavefields that have been separated in the time domain. We sort the residual wavefields in the time domain according to the order of absolute amplitudes. Then, the residual wavefields are separated into several groups in the time domain. To analyze the characteristics of the residual wavefields, we compare the residual wavefields of conventional method with those of our residual separation method. From the residual analysis, the amplitude spectrum obtained from the trace before separation appears to have little energy at the lower frequency bands. However, the amplitude spectrum obtained from our strategy is regularized by the separation process, which means that the low-frequency components are emphasized. Therefore, our method helps to emphasize low-frequency components of residual wavefields. Then, we generate the frequency-domain residual wavefields by taking the Fourier transform of the separated time-domain residual wavefields. With these wavefields, we perform the gradient-based full waveform inversion in the frequency domain using back-propagation technique. Through a comparison of gradient directions, we confirm that our separation method can better describe the sub-salt image than the conventional approach. The proposed method is tested on the SEG/EAGE salt-dome model. The inversion results show that our algorithm is better than the conventional gradient based waveform inversion in the frequency domain, especially for deeper parts of the velocity model.

Apoplastic domains and sub-domains in the shoots of etiolated corn seedlings

Science.gov (United States)

Epel, B. L.; Bandurski, R. S.

1990-01-01

Light Green, an apoplastic probe, was applied to the cut mesocotyl base or to the cut coleoptile apex of etiolated seedlings of Zea mays L. cv. Silver Queen. Probe transport was measured and its tissue distribution determined. In the mesocotyl, there is an apoplastic barrier between cortex and stele. This barrier creates two apoplastic domains which are non-communicating. A kinetic barrier exists between the apoplast of the mesocotyl stele and that of the coleoptile. This kinetic barrier is not absolute and there is limited communication between the apoplasts of the two regions. This kinetic barrier effectively creates two sub-domains. In the coleoptile, there is communication between the apoplast of the vascular strands and that of the surrounding cortical tissue. No apoplastic communication was observed between the coleoptile cortex and the mesocotyl cortex. Thus, the apoplastic space of the coleoptile cortex is a sub-domain of the integrated coleoptile domain and is separate from that of the apoplastic domain of the mesocotyl cortex.

Derivation of GPS TEC and receiver bias for Langkawi station in Malaysia

International Nuclear Information System (INIS)

Teh, W L; Abdullah, M; Chen, W S

2017-01-01

This paper presents the polynomial-type TEC model to derive total electron content (TEC) and receiver bias for Langkawi (LGKW) station in Malaysia at geographic latitude of 6.32° and longitude of 99.85°. The model uses a polynomial function of coordinates of the ionospheric piercing point to describe the TEC distribution in space. In the model, six polynomial coefficients and a receiver bias are unknown which can be solved by the least squares method. A reasonable agreement is achieved for the derivation of TEC and receiver bias for IENG station in Italy, as compared with that derived by the IGS analysis center, CODE. We process one year of LGKW data in 2010 and show the monthly receiver bias and the seasonal TEC variation. The monthly receiver bias varies between −48 and −24 TECu (10 16 electrons/m 2 ), with the mean value at −37 TECu. Large variations happen in the monthly receiver biases due to the low data coverage of high satellite elevation angle (60° < α ≤ 90°). Post-processing TEC approach is implemented which can resolve the wavy pattern of the monthly TEC baseline resulted from the large variation of the receiver bias. The seasonal TEC variation at LGKW exhibits a semi-annual variation, where the peak occurs during equinoctial months, and the trough during summer and winter months. (paper)

DIMA 3.0: Domain Interaction Map.

Science.gov (United States)

Luo, Qibin; Pagel, Philipp; Vilne, Baiba; Frishman, Dmitrij

2011-01-01

Domain Interaction MAp (DIMA, available at http://webclu.bio.wzw.tum.de/dima) is a database of predicted and known interactions between protein domains. It integrates 5807 structurally known interactions imported from the iPfam and 3did databases and 46,900 domain interactions predicted by four computational methods: domain phylogenetic profiling, domain pair exclusion algorithm correlated mutations and domain interaction prediction in a discriminative way. Additionally predictions are filtered to exclude those domain pairs that are reported as non-interacting by the Negatome database. The DIMA Web site allows to calculate domain interaction networks either for a domain of interest or for entire organisms, and to explore them interactively using the Flash-based Cytoscape Web software.

Wall shear stress fixed points in cardiovascular fluid mechanics.

Science.gov (United States)

Arzani, Amirhossein; Shadden, Shawn C

2018-05-17

Complex blood flow in large arteries creates rich wall shear stress (WSS) vectorial features. WSS acts as a link between blood flow dynamics and the biology of various cardiovascular diseases. WSS has been of great interest in a wide range of studies and has been the most popular measure to correlate blood flow to cardiovascular disease. Recent studies have emphasized different vectorial features of WSS. However, fixed points in the WSS vector field have not received much attention. A WSS fixed point is a point on the vessel wall where the WSS vector vanishes. In this article, WSS fixed points are classified and the aspects by which they could influence cardiovascular disease are reviewed. First, the connection between WSS fixed points and the flow topology away from the vessel wall is discussed. Second, the potential role of time-averaged WSS fixed points in biochemical mass transport is demonstrated using the recent concept of Lagrangian WSS structures. Finally, simple measures are proposed to quantify the exposure of the endothelial cells to WSS fixed points. Examples from various arterial flow applications are demonstrated. Copyright © 2018 Elsevier Ltd. All rights reserved.

Domain fusion analysis by applying relational algebra to protein sequence and domain databases.

Science.gov (United States)

Truong, Kevin; Ikura, Mitsuhiko

2003-05-06

Domain fusion analysis is a useful method to predict functionally linked proteins that may be involved in direct protein-protein interactions or in the same metabolic or signaling pathway. As separate domain databases like BLOCKS, PROSITE, Pfam, SMART, PRINTS-S, ProDom, TIGRFAMs, and amalgamated domain databases like InterPro continue to grow in size and quality, a computational method to perform domain fusion analysis that leverages on these efforts will become increasingly powerful. This paper proposes a computational method employing relational algebra to find domain fusions in protein sequence databases. The feasibility of this method was illustrated on the SWISS-PROT+TrEMBL sequence database using domain predictions from the Pfam HMM (hidden Markov model) database. We identified 235 and 189 putative functionally linked protein partners in H. sapiens and S. cerevisiae, respectively. From scientific literature, we were able to confirm many of these functional linkages, while the remainder offer testable experimental hypothesis. Results can be viewed at http://calcium.uhnres.utoronto.ca/pi. As the analysis can be computed quickly on any relational database that supports standard SQL (structured query language), it can be dynamically updated along with the sequence and domain databases, thereby improving the quality of predictions over time.

Characterization of the Functional Domains of a Mammalian Voltage-Sensitive Phosphatase.

Science.gov (United States)

Rosasco, Mario G; Gordon, Sharona E; Bajjalieh, Sandra M

2015-12-15

Voltage-sensitive phosphatases (VSPs) are proteins that directly couple changes in membrane electrical potential to inositol lipid phosphatase activity. VSPs thus couple two signaling pathways that are critical for cellular functioning. Although a number of nonmammalian VSPs have been characterized biophysically, mammalian VSPs are less well understood at both the physiological and biophysical levels. In this study, we aimed to address this gap in knowledge by determining whether the VSP from mouse, Mm-VSP, is expressed in the brain and contains a functional voltage-sensing domain (VSD) and a phosphatase domain. We report that Mm-VSP is expressed in neurons and is developmentally regulated. To address whether the functions of the VSD and phosphatase domain are retained in Mm-VSP, we took advantage of the modular nature of these domains and expressed each independently as a chimeric protein in a heterologous expression system. We found that the Mm-VSP VSD, fused to a viral potassium channel, was able to drive voltage-dependent gating of the channel pore. The Mm-VSP phosphatase domain, fused to the VSD of a nonmammalian VSP, was also functional: activation resulted in PI(4,5)P2 depletion that was sufficient to inhibit the PI(4,5)P2-regulated KCNQ2/3 channels. While testing the functionality of the VSD and phosphatase domain, we observed slight differences between the activities of Mm-VSP-based chimeras and those of nonmammalian VSPs. Although the properties of VSP chimeras may not completely reflect the properties of native VSPs, the differences we observed in voltage-sensing and phosphatase activity provide a starting point for future experiments to investigate the function of Mm-VSP and other mammalian VSPs. In conclusion, our data reveal that both the VSD and the lipid phosphatase domain of Mm-VSP are functional, indicating that Mm-VSP likely plays an important role in mouse neurophysiology. Copyright © 2015 Biophysical Society. Published by Elsevier Inc. All

Single-domain versus two-domain configuration in thin ferromagnetic prisms

International Nuclear Information System (INIS)

Pini, Maria Gloria; Politi, Paolo

2007-01-01

Thin ferromagnetic elements in the form of rectangular prisms are theoretically investigated in order to study the transition from single-domain to two-domain state, with changing the in-plane aspect ratio p. We address two main questions: first, how general is the transition; second, how the critical value p c depends on the physical parameters. We use two complementary methods: discrete-lattice calculations and a micromagnetic continuum approach. Ultrathin films do not appear to split in two domains. Instead, thicker films may undergo the above transition. We have used the continuum approach to analyze recent magnetic force microscopy observations in 30nm-thick patterned permalloy elements, finding a good agreement for p c

Topological domain walls in helimagnets

Science.gov (United States)

Schoenherr, P.; Müller, J.; Köhler, L.; Rosch, A.; Kanazawa, N.; Tokura, Y.; Garst, M.; Meier, D.

2018-05-01

Domain walls naturally arise whenever a symmetry is spontaneously broken. They interconnect regions with different realizations of the broken symmetry, promoting structure formation from cosmological length scales to the atomic level1,2. In ferroelectric and ferromagnetic materials, domain walls with unique functionalities emerge, holding great promise for nanoelectronics and spintronics applications3-5. These walls are usually of Ising, Bloch or Néel type and separate homogeneously ordered domains. Here we demonstrate that a wide variety of new domain walls occurs in the presence of spatially modulated domain states. Using magnetic force microscopy and micromagnetic simulations, we show three fundamental classes of domain walls to arise in the near-room-temperature helimagnet iron germanium. In contrast to conventional ferroics, the domain walls exhibit a well-defined inner structure, which—analogous to cholesteric liquid crystals—consists of topological disclination and dislocation defects. Similar to the magnetic skyrmions that form in the same material6,7, the domain walls can carry a finite topological charge, permitting an efficient coupling to spin currents and contributions to a topological Hall effect. Our study establishes a new family of magnetic nano-objects with non-trivial topology, opening the door to innovative device concepts based on helimagnetic domain walls.

Scalable domain decomposition solvers for stochastic PDEs in high performance computing

International Nuclear Information System (INIS)

Desai, Ajit; Pettit, Chris; Poirel, Dominique; Sarkar, Abhijit

2017-01-01

Stochastic spectral finite element models of practical engineering systems may involve solutions of linear systems or linearized systems for non-linear problems with billions of unknowns. For stochastic modeling, it is therefore essential to design robust, parallel and scalable algorithms that can efficiently utilize high-performance computing to tackle such large-scale systems. Domain decomposition based iterative solvers can handle such systems. And though these algorithms exhibit excellent scalabilities, significant algorithmic and implementational challenges exist to extend them to solve extreme-scale stochastic systems using emerging computing platforms. Intrusive polynomial chaos expansion based domain decomposition algorithms are extended here to concurrently handle high resolution in both spatial and stochastic domains using an in-house implementation. Sparse iterative solvers with efficient preconditioners are employed to solve the resulting global and subdomain level local systems through multi-level iterative solvers. We also use parallel sparse matrix–vector operations to reduce the floating-point operations and memory requirements. Numerical and parallel scalabilities of these algorithms are presented for the diffusion equation having spatially varying diffusion coefficient modeled by a non-Gaussian stochastic process. Scalability of the solvers with respect to the number of random variables is also investigated.

Prediction Reweighting for Domain Adaptation.

Science.gov (United States)

Shuang Li; Shiji Song; Gao Huang

2017-07-01

There are plenty of classification methods that perform well when training and testing data are drawn from the same distribution. However, in real applications, this condition may be violated, which causes degradation of classification accuracy. Domain adaptation is an effective approach to address this problem. In this paper, we propose a general domain adaptation framework from the perspective of prediction reweighting, from which a novel approach is derived. Different from the major domain adaptation methods, our idea is to reweight predictions of the training classifier on testing data according to their signed distance to the domain separator, which is a classifier that distinguishes training data (from source domain) and testing data (from target domain). We then propagate the labels of target instances with larger weights to ones with smaller weights by introducing a manifold regularization method. It can be proved that our reweighting scheme effectively brings the source and target domains closer to each other in an appropriate sense, such that classification in target domain becomes easier. The proposed method can be implemented efficiently by a simple two-stage algorithm, and the target classifier has a closed-form solution. The effectiveness of our approach is verified by the experiments on artificial datasets and two standard benchmarks, a visual object recognition task and a cross-domain sentiment analysis of text. Experimental results demonstrate that our method is competitive with the state-of-the-art domain adaptation algorithms.

A Multistage Decision-Feedback Receiver Design for LTE Uplink in Mobile Time-Variant Environments

Directory of Open Access Journals (Sweden)

Juinn-Horng Deng

2012-01-01

Full Text Available Single-carrier-frequency division multiple access (SC-FDMA has recently become the preferred uplink transmission scheme in long-term evolution (LTE systems. Similar to orthogonal frequency division multiple access (OFDMA, SC-FDMA is highly sensitive to frequency offsets caused by oscillator inaccuracies and Doppler spread, which lead to intercarrier interference (ICI. This work proposes a multistage decision-feedback structure to mitigate the ICI effect and enhance system performance in time-variant environments. Based on the block-type pilot arrangement of the LTE uplink type 1 frame structure, the time-domain least squares (TDLS method and polynomial-based curve-fitting algorithm are employed for channel estimation. Instead of using a conventional equalizer, this work uses a group frequency-domain equalizer (GFDE to reduce computational complexity. Furthermore, this work utilizes a dual iterative structure of group parallel interference cancellation (GPIC and frequency-domain group parallel interference cancellation (FPIC to mitigate the ICI effect. Finally, to optimize system performance, this work applies a novel error-correction scheme. Simulation results demonstrate the bit error rate (BER performance is markedly superior to that of the conventional full-size receiver based on minimum mean square error (MMSE. This structure performs well and is a flexible choice in mobile environments using the SC-FDMA scheme.

Supersymmetric domain walls

NARCIS (Netherlands)

Bergshoeff, Eric A.; Kleinschmidt, Axel; Riccioni, Fabio

2012-01-01

We classify the half-supersymmetric "domain walls," i.e., branes of codimension one, in toroidally compactified IIA/IIB string theory and show to which gauged supergravity theory each of these domain walls belong. We use as input the requirement of supersymmetric Wess-Zumino terms, the properties of

Site-specific genomic (SSG and random domain-localized (RDL mutagenesis in yeast

Directory of Open Access Journals (Sweden)

Honigberg Saul M

2004-04-01

Full Text Available Abstract Background A valuable weapon in the arsenal available to yeast geneticists is the ability to introduce specific mutations into yeast genome. In particular, methods have been developed to introduce deletions into the yeast genome using PCR fragments. These methods are highly efficient because they do not require cloning in plasmids. Results We have modified the existing method for introducing deletions in the yeast (S. cerevisiae genome using PCR fragments in order to target point mutations to this genome. We describe two PCR-based methods for directing point mutations into the yeast genome such that the final product contains no other disruptions. In the first method, site-specific genomic (SSG mutagenesis, a specific point mutation is targeted into the genome. In the second method, random domain-localized (RDL mutagenesis, a mutation is introduced at random within a specific domain of a gene. Both methods require two sequential transformations, the first transformation integrates the URA3 marker into the targeted locus, and the second transformation replaces URA3 with a PCR fragment containing one or a few mutations. This PCR fragment is synthesized using a primer containing a mutation (SSG mutagenesis or is synthesized by error-prone PCR (RDL mutagenesis. In SSG mutagenesis, mutations that are proximal to the URA3 site are incorporated at higher frequencies than distal mutations, however mutations can be introduced efficiently at distances of at least 500 bp from the URA3 insertion. In RDL mutagenesis, to ensure that incorporation of mutations occurs at approximately equal frequencies throughout the targeted region, this region is deleted at the same time URA3 is integrated. Conclusion SSG and RDL mutagenesis allow point mutations to be easily and efficiently incorporated into the yeast genome without disrupting the native locus.

Diversity receiver

NARCIS (Netherlands)

2005-01-01

The invention is directed to the reception of high rate radio signals (for example DVB-T signals) while the receiver is moving at a high speed (for example in or with a car). Two or more antennas (12, 16) are closely spaced and arranged behind each other in the direction of motion (v) for receiving

Polarization Characteristics Inferred From the Radio Receiver Instrument on the Enhanced Polar Outflow Probe

Science.gov (United States)

Danskin, Donald W.; Hussey, Glenn C.; Gillies, Robert G.; James, H. Gordon; Fairbairn, David T.; Yau, Andrew W.

2018-02-01

The Radio Receiver Instrument (RRI) on the CAScade, Smallsat, and Ionospheric Polar Explorer/enhanced Polar Outflow Probe (CASSIOPE/e-POP) satellite was used to receive continuous wave and binary phase shift keyed transmissions from a high-frequency transmitter located in Ottawa, ON, Canada during April 2016 to investigate how the ionosphere affects the polarization characteristics of transionospheric high-frequency radio waves. The spacecraft orientation was continuously slewed to maintain the dipole orientation in a plane perpendicular to the direction toward the transmitter, enabling the first in situ planar polarization determination for continuous wave and binary phase shift keyed modulated radio waves from space at times when the wave frequency is at least 1.58 times the plasma frequency. The Stokes parameters and polarization characteristics were derived from the measured data and interpreted using an existing ray tracing model. For the southern part of the passes, the power was observed to oscillate between the two dipoles of RRI, which was attributed to Faraday rotation of the radio waves. For the first time, a reversal in the rate of change of orientation angle was observed where the minimum in modeled Faraday rotation occurred. The reversal point was poleward of the point of closest approach between the satellite and transmitter; this was explained by the variations of total electron content and component of magnetic field along the direction of propagation. The received signals show both quasi-longitudinal (QL) and quasi-transverse characteristics. South of the transmitter the QL regime is dominant. Around the reversal point, a combination of QL and quasi-transverse nature was observed.

Quality of life of elderly individuals receiving literacy training: a longitudinal study

Directory of Open Access Journals (Sweden)

Bruna Rodrigues dos Santos

2015-04-01

Full Text Available Because of population aging in Brazil, educational programs directed to young and adult individuals now have to absorb a large number of 60 year old or older individuals. Objectives: Identify the relationships among the variables quality of life, time attending the program, depressive symptoms, and cognitive status; and longitudinally compare the scores concerning the quality of life of these individuals. Method: Descriptive, correlational, comparative, longitudinal and quantitative study. The participants were elderly individuals who attended literacy training provided in a Brazilian city from 2012 to 2014. The instruments to collect data included sociodemographic characterization, the WHOQOL-bref, WHOQOL-old, the Geriatric Depression Scale (GDS, and the Mini Mental State Examination. Results: The participants were predominantly young-elderly women, with low incomes. Scores obtained on the GDS were related with the domains: Physical (p<0.05; Environment (p<0.01; Autonomy (p<0.01, Past, Present and Future Activities (p<0.05, Intimacy (p<0.01; and Social Relationships (p<0.01. The scores concerning cognition were related to the Autonomy domain (p<0.01. The physical domain of quality of life presented significant worsening in 2013 when compared to 2012 (M1=70.23; M2=61.20;M3=62.40. These results cannot be generalized because they concern only elderly individuals receiving literacy training provided in a midsized city in the interior of São Paulo, Brazil.

APP processing and the APP-KPI domain involvement in the amyloid cascade.

Science.gov (United States)

Menéndez-González, M; Pérez-Pinera, P; Martínez-Rivera, M; Calatayud, M T; Blázquez Menes, B

2005-01-01

Alternative APP mRNA splicing can generate isoforms of APP containing a Kunitz protease inhibitor (KPI) domain. KPI is one of the main serine protease inhibitors. Protein and mRNA KPI(+)APP levels are elevated in Alzheimer's disease (AD) brain and are associated with increased amyloid beta deposition. In the last years increasing evidence on multiple points in the amyloid cascade where KPI(+)APP is involved has been accumulated, admitting an outstanding position in the pathogenesis of AD to the KPI domain. This review focuses on the APP processing, the molecular activity of KPI and its physiological and pathological roles and the KPI involvement in the amyloid cascade through the nerve growth factor, the lipoprotein receptor-related protein, the tumor necrosis factor-alpha converting enzyme and the Notch1 protein.

MULTIPLE ACCESS POINTS WITHIN THE ONLINE CLASSROOM: WHERE STUDENTS LOOK FOR INFORMATION

Directory of Open Access Journals (Sweden)

John STEELE

2017-01-01

Full Text Available The purpose of this study is to examine the impact of information placement within the confines of the online classroom architecture. Also reviewed was the impact of other variables such as course design, teaching presence and student patterns in looking for information. The sample population included students from a major online university in their first year course sequence. Students were tasked with completing a survey at the end of the course, indicating their preference for accessing information within the online classroom. The qualitative data indicated that student preference is to receive information from multiple access points and sources within the online classroom architecture. Students also expressed a desire to have information delivered through the usage of technology such as email and text messaging. In addition to receiving information from multiple sources, the qualitative data indicated students were satisfied overall, with the current ways in which they received and accessed information within the online classroom setting. Major findings suggest that instructors teaching within the online classroom should have multiple data access points within the classroom architecture. Furthermore, instructors should use a variety of communication venues to enhance the ability for students to access and receive information pertinent to the course.

Domain walls of gauged supergravity, M-branes and algebraic curves

CERN Document Server

Bakas, I.; Sfetsos, K.

1999-01-01

We provide an algebraic classification of all supersymmetric domain wall solutions of maximal gauged supergravity in four and seven dimensions, in the presence of non-trivial scalar fields in the coset SL(8,R)/SO(8) and SL(5,R)/SO(5) respectively. These solutions satisfy first-order equations, which can be obtained using the method of Bogomol'nyi. From an eleven-dimensional point of view they correspond to various continuous distributions of M2- and M5-branes. The Christoffel-Schwarz transformation and the uniformization of the associated algebraic curves are used in order to determine the Schrodinger potential for the scalar and graviton fluctuations on the corresponding backgrounds. In many cases we explicitly solve the Schrodinger problem by employing techniques of supersymmetric quantum mechanics. The analysis is parallel to the construction of domain walls of five-dimensional gauged supergravity, with scalar fields in the coset SL(6,R)/SO(6), using algebraic curves or continuous distributions of D3-brane...

Bicontinuous structured liquids with sub-micrometre domains using nanoparticle surfactants

Science.gov (United States)

Huang, Caili; Forth, Joe; Wang, Weiyu; Hong, Kunlun; Smith, Gregory S.; Helms, Brett A.; Russell, Thomas P.

2017-11-01

Bicontinuous jammed emulsions (or bijels) are tortuous, interconnected structures of two immiscible liquids, kinetically trapped by colloidal particles that are irreversibly bound to the oil-water interface. A wealth of applications has been proposed for bijels in catalysis, energy storage and molecular encapsulation, but large domain sizes (on the order of 5 µm or larger) and difficulty in fabrication pose major barriers to their use. Here, we show that bijels with sub-micrometre domains can be formed via homogenization, rather than spinodal decomposition. We achieve this by using nanoparticle surfactants: polymers and nanoparticles of complementary functionality (for example, ion-pairing) that bind to one another at the oil-water interface. This allows the stabilization of the bijel far from the demixing point of the liquids, with interfacial tensions on the order of 20 mN m-1. Furthermore, our strategy is extremely versatile, as solvent, nanoparticle and ligand can all be varied.

A point-value enhanced finite volume method based on approximate delta functions

Science.gov (United States)

Xuan, Li-Jun; Majdalani, Joseph

2018-02-01

We revisit the concept of an approximate delta function (ADF), introduced by Huynh (2011) [1], in the form of a finite-order polynomial that holds identical integral properties to the Dirac delta function when used in conjunction with a finite-order polynomial integrand over a finite domain. We show that the use of generic ADF polynomials can be effective at recovering and generalizing several high-order methods, including Taylor-based and nodal-based Discontinuous Galerkin methods, as well as the Correction Procedure via Reconstruction. Based on the ADF concept, we then proceed to formulate a Point-value enhanced Finite Volume (PFV) method, which stores and updates the cell-averaged values inside each element as well as the unknown quantities and, if needed, their derivatives on nodal points. The sharing of nodal information with surrounding elements saves the number of degrees of freedom compared to other compact methods at the same order. To ensure conservation, cell-averaged values are updated using an identical approach to that adopted in the finite volume method. Here, the updating of nodal values and their derivatives is achieved through an ADF concept that leverages all of the elements within the domain of integration that share the same nodal point. The resulting scheme is shown to be very stable at successively increasing orders. Both accuracy and stability of the PFV method are verified using a Fourier analysis and through applications to the linear wave and nonlinear Burgers' equations in one-dimensional space.

Higher-order triangular spectral element method with optimized cubature points for seismic wavefield modeling

Energy Technology Data Exchange (ETDEWEB)

Liu, Youshan, E-mail: ysliu@mail.iggcas.ac.cn [State Key Laboratory of Lithospheric Evolution, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, 100029 (China); Teng, Jiwen, E-mail: jwteng@mail.iggcas.ac.cn [State Key Laboratory of Lithospheric Evolution, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, 100029 (China); Xu, Tao, E-mail: xutao@mail.iggcas.ac.cn [State Key Laboratory of Lithospheric Evolution, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, 100029 (China); CAS Center for Excellence in Tibetan Plateau Earth Sciences, Beijing, 100101 (China); Badal, José, E-mail: badal@unizar.es [Physics of the Earth, Sciences B, University of Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza (Spain)

2017-05-01

The mass-lumped method avoids the cost of inverting the mass matrix and simultaneously maintains spatial accuracy by adopting additional interior integration points, known as cubature points. To date, such points are only known analytically in tensor domains, such as quadrilateral or hexahedral elements. Thus, the diagonal-mass-matrix spectral element method (SEM) in non-tensor domains always relies on numerically computed interpolation points or quadrature points. However, only the cubature points for degrees 1 to 6 are known, which is the reason that we have developed a p-norm-based optimization algorithm to obtain higher-order cubature points. In this way, we obtain and tabulate new cubature points with all positive integration weights for degrees 7 to 9. The dispersion analysis illustrates that the dispersion relation determined from the new optimized cubature points is comparable to that of the mass and stiffness matrices obtained by exact integration. Simultaneously, the Lebesgue constant for the new optimized cubature points indicates its surprisingly good interpolation properties. As a result, such points provide both good interpolation properties and integration accuracy. The Courant–Friedrichs–Lewy (CFL) numbers are tabulated for the conventional Fekete-based triangular spectral element (TSEM), the TSEM with exact integration, and the optimized cubature-based TSEM (OTSEM). A complementary study demonstrates the spectral convergence of the OTSEM. A numerical example conducted on a half-space model demonstrates that the OTSEM improves the accuracy by approximately one order of magnitude compared to the conventional Fekete-based TSEM. In particular, the accuracy of the 7th-order OTSEM is even higher than that of the 14th-order Fekete-based TSEM. Furthermore, the OTSEM produces a result that can compete in accuracy with the quadrilateral SEM (QSEM). The high accuracy of the OTSEM is also tested with a non-flat topography model. In terms of computational

Higher-order triangular spectral element method with optimized cubature points for seismic wavefield modeling

International Nuclear Information System (INIS)

Liu, Youshan; Teng, Jiwen; Xu, Tao; Badal, José

2017-01-01

The mass-lumped method avoids the cost of inverting the mass matrix and simultaneously maintains spatial accuracy by adopting additional interior integration points, known as cubature points. To date, such points are only known analytically in tensor domains, such as quadrilateral or hexahedral elements. Thus, the diagonal-mass-matrix spectral element method (SEM) in non-tensor domains always relies on numerically computed interpolation points or quadrature points. However, only the cubature points for degrees 1 to 6 are known, which is the reason that we have developed a p-norm-based optimization algorithm to obtain higher-order cubature points. In this way, we obtain and tabulate new cubature points with all positive integration weights for degrees 7 to 9. The dispersion analysis illustrates that the dispersion relation determined from the new optimized cubature points is comparable to that of the mass and stiffness matrices obtained by exact integration. Simultaneously, the Lebesgue constant for the new optimized cubature points indicates its surprisingly good interpolation properties. As a result, such points provide both good interpolation properties and integration accuracy. The Courant–Friedrichs–Lewy (CFL) numbers are tabulated for the conventional Fekete-based triangular spectral element (TSEM), the TSEM with exact integration, and the optimized cubature-based TSEM (OTSEM). A complementary study demonstrates the spectral convergence of the OTSEM. A numerical example conducted on a half-space model demonstrates that the OTSEM improves the accuracy by approximately one order of magnitude compared to the conventional Fekete-based TSEM. In particular, the accuracy of the 7th-order OTSEM is even higher than that of the 14th-order Fekete-based TSEM. Furthermore, the OTSEM produces a result that can compete in accuracy with the quadrilateral SEM (QSEM). The high accuracy of the OTSEM is also tested with a non-flat topography model. In terms of computational

Some application of the model of partition points on a one-dimensional lattice

International Nuclear Information System (INIS)

Mejdani, R.

1991-07-01

We have shown that by using a model of the gas of partition points on one-dimensional lattice, we can find some results about the enzyme kinetics or the average domain-size, which we have obtained before by using a correlated Walks' theory or a probabilistic (combinatoric) way. We have discussed also the problem related with the spread of an infection of disease and the stochastic model of partition points. We think that this model, as a very simple model and mathematically transparent, can be advantageous for other theoretical investigations in chemistry or modern biology. (author). 14 refs, 6 figs, 1 tab

Interoperable domain models: the ISO land administration domain model LADM and its external classes

CSIR Research Space (South Africa)

Lemmen, CHJ

2011-09-01

Full Text Available This paper provides a brief overview of one of the first spatial domain standards: a standard for the domain of Land Administration (LA). This standard is in the draft stage of development now (May 2011). The development of domain standards is a...

Efficient 3D Volume Reconstruction from a Point Cloud Using a Phase-Field Method

Directory of Open Access Journals (Sweden)

Darae Jeong

2018-01-01

Full Text Available We propose an explicit hybrid numerical method for the efficient 3D volume reconstruction from unorganized point clouds using a phase-field method. The proposed three-dimensional volume reconstruction algorithm is based on the 3D binary image segmentation method. First, we define a narrow band domain embedding the unorganized point cloud and an edge indicating function. Second, we define a good initial phase-field function which speeds up the computation significantly. Third, we use a recently developed explicit hybrid numerical method for solving the three-dimensional image segmentation model to obtain efficient volume reconstruction from point cloud data. In order to demonstrate the practical applicability of the proposed method, we perform various numerical experiments.

Feature Extraction from 3D Point Cloud Data Based on Discrete Curves

Directory of Open Access Journals (Sweden)

Yi An

2013-01-01

Full Text Available Reliable feature extraction from 3D point cloud data is an important problem in many application domains, such as reverse engineering, object recognition, industrial inspection, and autonomous navigation. In this paper, a novel method is proposed for extracting the geometric features from 3D point cloud data based on discrete curves. We extract the discrete curves from 3D point cloud data and research the behaviors of chord lengths, angle variations, and principal curvatures at the geometric features in the discrete curves. Then, the corresponding similarity indicators are defined. Based on the similarity indicators, the geometric features can be extracted from the discrete curves, which are also the geometric features of 3D point cloud data. The threshold values of the similarity indicators are taken from [0,1], which characterize the relative relationship and make the threshold setting easier and more reasonable. The experimental results demonstrate that the proposed method is efficient and reliable.

Approximate controllability of a semilinear elliptic problem with Robin condition in a periodically perforated domain

Directory of Open Access Journals (Sweden)

Nikita Agarwal

2017-07-01

Full Text Available In this article, we study the approximate controllability and homegenization results of a semi-linear elliptic problem with Robin boundary condition in a periodically perforated domain. We prove the existence of minimal norm control using Lions constructive approach, which is based on Fenchel-Rockafeller duality theory, and by means of Zuazua's fixed point arguments. Then, as the homogenization parameter goes to zero, we link the limit of the optimal controls (the limit of fixed point of the controllability problems with the optimal control of the corresponding homogenized problem.

Domain-based small molecule binding site annotation

Directory of Open Access Journals (Sweden)

Dumontier Michel

2006-03-01

Full Text Available Abstract Background Accurate small molecule binding site information for a protein can facilitate studies in drug docking, drug discovery and function prediction, but small molecule binding site protein sequence annotation is sparse. The Small Molecule Interaction Database (SMID, a database of protein domain-small molecule interactions, was created using structural data from the Protein Data Bank (PDB. More importantly it provides a means to predict small molecule binding sites on proteins with a known or unknown structure and unlike prior approaches, removes large numbers of false positive hits arising from transitive alignment errors, non-biologically significant small molecules and crystallographic conditions that overpredict ion binding sites. Description Using a set of co-crystallized protein-small molecule structures as a starting point, SMID interactions were generated by identifying protein domains that bind to small molecules, using NCBI's Reverse Position Specific BLAST (RPS-BLAST algorithm. SMID records are available for viewing at http://smid.blueprint.org. The SMID-BLAST tool provides accurate transitive annotation of small-molecule binding sites for proteins not found in the PDB. Given a protein sequence, SMID-BLAST identifies domains using RPS-BLAST and then lists potential small molecule ligands based on SMID records, as well as their aligned binding sites. A heuristic ligand score is calculated based on E-value, ligand residue identity and domain entropy to assign a level of confidence to hits found. SMID-BLAST predictions were validated against a set of 793 experimental small molecule interactions from the PDB, of which 472 (60% of predicted interactions identically matched the experimental small molecule and of these, 344 had greater than 80% of the binding site residues correctly identified. Further, we estimate that 45% of predictions which were not observed in the PDB validation set may be true positives. Conclusion By

A study of the border between the domains of production and acquisition of knowledge in higher education

DEFF Research Database (Denmark)

Busch, Henrik

2001-01-01

This paper focuses on a common feature of most undergraduate studies in science - the pronounced border between the domains of production and acquisition of knowledge. Under¬graduate students' learning activities and settings are characterized by little inter¬action with the community of practicing...... scientists. Based on ongoing ethnographic field work, certain aspects of this division between the two domains are discussed from an educational point of view. A case study is presented and leads to considerations about undergraduate students' access to the culture of practicing physicists....

Multifunctionalities driven by ferroic domains

Science.gov (United States)

Yang, J. C.; Huang, Y. L.; He, Q.; Chu, Y. H.

2014-08-01

Considerable attention has been paid to ferroic systems in pursuit of advanced applications in past decades. Most recently, the emergence and development of multiferroics, which exhibit the coexistence of different ferroic natures, has offered a new route to create functionalities in the system. In this manuscript, we step from domain engineering to explore a roadmap for discovering intriguing phenomena and multifunctionalities driven by periodic domain patters. As-grown periodic domains, offering exotic order parameters, periodic local perturbations and the capability of tailoring local spin, charge, orbital and lattice degrees of freedom, are introduced as modeling templates for fundamental studies and novel applications. We discuss related significant findings on ferroic domain, nanoscopic domain walls, and conjunct heterostructures based on the well-organized domain patterns, and end with future prospects and challenges in the field.

Critical Point Cancellation in 3D Vector Fields: Robustness and Discussion.

Science.gov (United States)

Skraba, Primoz; Rosen, Paul; Wang, Bei; Chen, Guoning; Bhatia, Harsh; Pascucci, Valerio

2016-02-29

Vector field topology has been successfully applied to represent the structure of steady vector fields. Critical points, one of the essential components of vector field topology, play an important role in describing the complexity of the extracted structure. Simplifying vector fields via critical point cancellation has practical merit for interpreting the behaviors of complex vector fields such as turbulence. However, there is no effective technique that allows direct cancellation of critical points in 3D. This work fills this gap and introduces the first framework to directly cancel pairs or groups of 3D critical points in a hierarchical manner with a guaranteed minimum amount of perturbation based on their robustness, a quantitative measure of their stability. In addition, our framework does not require the extraction of the entire 3D topology, which contains non-trivial separation structures, and thus is computationally effective. Furthermore, our algorithm can remove critical points in any subregion of the domain whose degree is zero and handle complex boundary configurations, making it capable of addressing challenging scenarios that may not be resolved otherwise. We apply our method to synthetic and simulation datasets to demonstrate its effectiveness.

All-Digital Time-Domain CMOS Smart Temperature Sensor with On-Chip Linearity Enhancement.

Science.gov (United States)

Chen, Chun-Chi; Chen, Chao-Lieh; Lin, Yi

2016-01-30

This paper proposes the first all-digital on-chip linearity enhancement technique for improving the accuracy of the time-domain complementary metal-oxide semiconductor (CMOS) smart temperature sensor. To facilitate on-chip application and intellectual property reuse, an all-digital time-domain smart temperature sensor was implemented using 90 nm Field Programmable Gate Arrays (FPGAs). Although the inverter-based temperature sensor has a smaller circuit area and lower complexity, two-point calibration must be used to achieve an acceptable inaccuracy. With the help of a calibration circuit, the influence of process variations was reduced greatly for one-point calibration support, reducing the test costs and time. However, the sensor response still exhibited a large curvature, which substantially affected the accuracy of the sensor. Thus, an on-chip linearity-enhanced circuit is proposed to linearize the curve and achieve a new linearity-enhanced output. The sensor was implemented on eight different Xilinx FPGA using 118 slices per sensor in each FPGA to demonstrate the benefits of the linearization. Compared with the unlinearized version, the maximal inaccuracy of the linearized version decreased from 5 °C to 2.5 °C after one-point calibration in a range of -20 °C to 100 °C. The sensor consumed 95 μW using 1 kSa/s. The proposed linearity enhancement technique significantly improves temperature sensing accuracy, avoiding costly curvature compensation while it is fully synthesizable for future Very Large Scale Integration (VLSI) system.

Text Processing of Domain-Related Information for Individuals with High and Low Domain Knowledge.

Science.gov (United States)

Spilich, George J.; And Others

1979-01-01

The way in which previously acquired knowledge affects the processing on new domain-related information was investigated. Text processing was studied in two groups differing in knowledge of the domain of baseball. A knowledge structure for the domain was constructed, and text propositions were classified. (SW)

Receiving efficiency of monostatic pulsed coherent lidars. I - Theory. II - Applications

Science.gov (United States)

Zhao, Yanzeng; Post, Madison J.; Hardesty, Michael

1990-01-01

Pulsed coherent radars' receiving efficiency, eta, is presently investigated as a function of range z on the basis of a theory which relates eta(z) to both the transmitted laser intensity and the point-source receiving efficiency; this efficiency is calculated by a backward method employing the back-propagated local oscillator (BPLO) approach. The theory is applied to the ideal case, in order to study system optimization when both the transmitted and the BPLO fields at the antenna are Gaussian. In the second part of this work, eta(z) is calculated for various conditions of the NOAA/ERL Wave Propagation Laboratory CO2 Doppler lidar; the sensitivity of eta(z) to transmitted laser beam quality, telescope focal setting, telescope power, scanner astigmatism, and system misalignment.