WorldWideScience

Sample records for real-life exabyte-scale test-case

  1. Can Clouds Replace Grids? A Real-Life Exabyte-Scale Test-Case

    CERN Document Server

    Shiers, J

    2008-01-01

    The world’s largest scientific machine – comprising dual 27km circular proton accelerators cooled to 1.9oK and located some 100m underground – currently relies on major production Grid infrastructures for the offline computing needs of the 4 main experiments that will take data at this facility. After many years of sometimes difficult preparation the computing service has been declared â€ワopen” and ready to meet the challenges that will come shortly when the machine restarts in 2009. But the service is not without its problems: reliability – as seen by the experiments, as opposed to that measured by the official tools – still needs to be significantly improved. Prolonged downtimes or degradations of major services or even complete sites are still too common and the operational and coordination effort to keep the overall service running is probably not sustainable at this level. Recently â€ワCloud Computing” – in terms of pay-per-use fabric provisioning – has...

  2. Operation of ULCS - real life

    Directory of Open Access Journals (Sweden)

    Jasna Prpić-Oršić

    2014-12-01

    Full Text Available In this paper the real life operation of ULCS (Ultra Large Container Ships is presented from the point of view of shipmasters. The paper provides interpretation of results of questionnaire filled by masters of large container ships during Tools for Ultra Large Container Ships (TULC EUI FP7 project. This is done in a way that results of questionnaire are further reviewed and commented by experienced master of ULCS. Following phenomena are subject of questionnaire and further discussed in the paper: parametric rolling, slamming, whipping, springing, green water and rogue waves. Special attention is given to the definition of rough sea states as well as to measures that ship masters take to avoid them as well as to the manoeuvring in heavy seas. The role of the wave forecast and weather routing software is also discussed.

  3. Endangered Species: Real Life in Two Dimensions

    Science.gov (United States)

    Henderson, Lynette K.

    2012-01-01

    The focus of "Endangered Species: Real Life in Two Dimensions" is to create awareness about a critical environmental issue. There is a special urgency to this project because large numbers of animal species are currently endangered or on the brink of extinction. In addition to being enlightened about this important topic through research, students…

  4. Real-life applications with membrane computing

    CERN Document Server

    Zhang, Gexiang; Gheorghe, Marian

    2017-01-01

    This book thoroughly investigates the underlying theoretical basis of membrane computing models, and reveals their latest applications. In addition, to date there have been no illustrative case studies or complex real-life applications that capitalize on the full potential of the sophisticated membrane systems computational apparatus; gaps that this book remedies. By studying various complex applications – including engineering optimization, power systems fault diagnosis, mobile robot controller design, and complex biological systems involving data modeling and process interactions – the book also extends the capabilities of membrane systems models with features such as formal verification techniques, evolutionary approaches, and fuzzy reasoning methods. As such, the book offers a comprehensive and up-to-date guide for all researchers, PhDs and undergraduate students in the fields of computer science, engineering and the bio-sciences who are interested in the applications of natural computing models.

  5. Comparative Test Case Specification

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

     This document includes a definition of the comparative test cases DSF200_3 and DSF200_4, which previously described in the comparative test case specification for the test cases DSF100_3 and DSF200_3 [Ref.1]....... This document includes a definition of the comparative test cases DSF200_3 and DSF200_4, which previously described in the comparative test case specification for the test cases DSF100_3 and DSF200_3 [Ref.1]....

  6. Disease spreading in real-life networks

    Science.gov (United States)

    Gallos, Lazaros; Argyrakis, Panos

    2002-08-01

    In recent years the scientific community has shown a vivid interest in the network structure and dynamics of real-life organized systems. Many such systems, covering an extremely wide range of applications, have been recently shown to exhibit scale-free character in their connectivity distribution, meaning that they obey a power law. Modeling of epidemics on lattices and small-world networks suffers from the presence of a critical infection threshold, above which the entire population is infected. For scale-free networks, the original assumption was that the formation of a giant cluster would lead to an epidemic spreading in the same way as in simpler networks. Here we show that modeling epidemics on a scale-free network can greatly improve the predictions on the rate and efficiency of spreading, as compared to lattice models and small-world networks. We also show that the dynamics of a disease are greatly influenced by the underlying population structure. The exact same model can describe a plethora of networks, such as social networks, virus spreading in the Web, rumor spreading, signal transmission etc.

  7. Gamer Girls, Gold Farmers, and Activism "In Real Life"

    Science.gov (United States)

    Musgrave, Megan L.

    2016-01-01

    This essay analyzes the graphic novel "In Real Life" as an example of Cory Doctorow and Jen Wang's intention to raise young people's awareness about gender and economic disparities within the gaming industry. Broadly, "In Real Life" combats the pervasive cultural anxiety that Jane McGonigal challenges in her book "Reality…

  8. An adaptation framework for turning real life events into games

    DEFF Research Database (Denmark)

    Therkildsen, Sacha Kjærhus; Bunkenborg, Nanna Cassøe; Larsen, Lasse Juel

    2017-01-01

    Many games are inspired by real life events. The presented adaptation framework is based on the design of a board game with a companion app that addresses the Syrian refugee crisis. The aim of the game is to allow players to simulate the experience of being a Syrian refugee traveling through Europe....... We applied an agile development method and participatory design to achieve our ambition. In conclusion we found that turning real life events into board games can be advanced by the following game design adaptation framework, which balances four interrelated layers: (1) real life events (game fiction...

  9. Comparative Test Case Specification

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

    This document includes the specification on the IEA task of evaluation building energy simulation computer programs for the Double Skin Facades (DSF) constructions. There are two approaches involved into this procedure, one is the comparative approach and another is the empirical one. In the comp....... In the comparative approach the outcomes of different software tools are compared, while in the empirical approach the modelling results are compared with the results of experimental test cases. The comparative test cases include: ventilation, shading and geometry....

  10. Competence and Quality in Real-Life Decision Making

    OpenAIRE

    Geisler, Martin; Allwood, Carl Martin

    2015-01-01

    What distinguishes a competent decision maker and how should the issue of decision quality be approached in a real-life context? These questions were explored in three studies. In Study 1, using a web-based questionnaire and targeting a community sample, we investigated the relationships between objective and subjective indicators of real-life decision-making success. In Study 2 and 3, targeting two different samples of professionals, we explored if the prevalent cognitively oriented definiti...

  11. Empirical Test Case Specification

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

    This document includes the empirical specification on the IEA task of evaluation building energy simulation computer programs for the Double Skin Facades (DSF) constructions. There are two approaches involved into this procedure, one is the comparative approach and another is the empirical one. I....... In the comparative approach the outcomes of different software tools are compared, while in the empirical approach the modelling results are compared with the results of experimental test cases....

  12. Automated Test Case Generation

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    I would like to present the concept of automated test case generation. I work on it as part of my PhD and I think it would be interesting also for other people. It is also the topic of a workshop paper that I am introducing in Paris. (abstract below) Please note that the talk itself would be more general and not about the specifics of my PhD, but about the broad field of Automated Test Case Generation. I would introduce the main approaches (combinatorial testing, symbolic execution, adaptive random testing) and their advantages and problems. (oracle problem, combinatorial explosion, ...) Abstract of the paper: Over the last decade code-based test case generation techniques such as combinatorial testing or dynamic symbolic execution have seen growing research popularity. Most algorithms and tool implementations are based on finding assignments for input parameter values in order to maximise the execution branch coverage. Only few of them consider dependencies from outside the Code Under Test’s scope such...

  13. Real-Life Efficacy, Immunogenicity and Safety of Biosimilar Infliximab.

    Science.gov (United States)

    Vegh, Zsuzsanna; Kurti, Zsuzsanna; Lakatos, Peter L

    2017-01-01

    Recently, the use of biosimilar infliximab (IFX) in the treatment of inflammatory bowel diseases has become widespread in some European and non-European countries. Data on the efficacy, safety and immunogenicity from real-life cohorts are accumulating. The first reports showed similar outcomes in the induction and maintenance of remission, mucosal healing, safety and immunogenicity profile to the originator IFX. In the present review, we aimed to summarize the existing knowledge on the efficacy, safety and immunogenicity profile of biosimilar IFX reported from real-life cohorts. © 2017 S. Karger AG, Basel.

  14. Children's Eyewitness Memory for Multiple Real-Life Events

    Science.gov (United States)

    Odegard, Timothy N.; Cooper, Crystal M.; Lampinen, James M.; Reyna, Valerie F.; Brainerd, Charles J.

    2009-01-01

    The present research examined the influence of prior knowledge on children's free recall, cued recall, recognition memory, and source memory judgments for a series of similar real-life events. Forty children (5-12 years old) attended 4 thematic birthday parties and were later interviewed about the events that transpired during the parties using…

  15. Improvisation of Real-Life Scenarios through Intercultural Competence

    Science.gov (United States)

    Okten, Celile Eren; Griffin, Banu Ozer

    2016-01-01

    This paper describes tasks based on real-life scenarios, which triggered reflective thinking, verbalization, and writing, leading to the creation of natural dialogues rather than artificial, dull monologues. One of the main aims of this approach is to engage students in a dynamic process of both learning about multicultural participants and…

  16. Real Life Lab BIPV field testing in the Netherlands

    NARCIS (Netherlands)

    Ritzen, M.; Vroon, Z.; Rovers, R.; Geurts, C.; Blocken, B.

    2015-01-01

    Integration of PV in the Building Envelope (BIPV) is one of the four key developments necessary for large market PV penetration, together with PV efficiency improvement, price decrease and electricity storage [1]. In the course of BIPV development, Real-Life Lab demonstration projects are realized

  17. Real life lab BIPV field testing in the Netherlands

    NARCIS (Netherlands)

    Ritzen, M.J.; Vroon, Z.; Geurts, C.P.W.; Rovers, R.; Blocken, B.J.E.

    2015-01-01

    Integration of PV in the Building Envelope (BIPV) is one of the four key developments necessary for large market PV penetration, together with PV efficiency improvement, price decrease and electricity storage [1]. In the course of BIPV development, Real-Life Lab demonstration projects are realized

  18. Rendezvous with IQ: Metacognition in Real-Life Situations

    Science.gov (United States)

    Al-Hilawani, Yasser A.

    2018-01-01

    The purpose of this study was to examine the relationship between metacognition as measured in real-life situations and IQ scores as reflected by performance on the Raven Standard Progressive Matrices Scale. It is also intended in this study to report on whether or not there were significant differences in performance on the metacognitive…

  19. Competence and Quality in Real-Life Decision Making

    Science.gov (United States)

    2015-01-01

    What distinguishes a competent decision maker and how should the issue of decision quality be approached in a real-life context? These questions were explored in three studies. In Study 1, using a web-based questionnaire and targeting a community sample, we investigated the relationships between objective and subjective indicators of real-life decision-making success. In Study 2 and 3, targeting two different samples of professionals, we explored if the prevalent cognitively oriented definition of decision-making competence could be beneficially expanded by adding aspects of competence in terms of social skills and time-approach. The predictive power for each of these three aspects of decision-making competence was explored for different indicators of real-life decision-making success. Overall, our results suggest that research on decision-making competence would benefit by expanding the definition of competence, by including decision-related abilities in terms of social skills and time-approach. Finally, the results also indicate that individual differences in real-life decision-making success profitably can be approached and measured by different criteria. PMID:26545239

  20. Competence and Quality in Real-Life Decision Making.

    Science.gov (United States)

    Geisler, Martin; Allwood, Carl Martin

    2015-01-01

    What distinguishes a competent decision maker and how should the issue of decision quality be approached in a real-life context? These questions were explored in three studies. In Study 1, using a web-based questionnaire and targeting a community sample, we investigated the relationships between objective and subjective indicators of real-life decision-making success. In Study 2 and 3, targeting two different samples of professionals, we explored if the prevalent cognitively oriented definition of decision-making competence could be beneficially expanded by adding aspects of competence in terms of social skills and time-approach. The predictive power for each of these three aspects of decision-making competence was explored for different indicators of real-life decision-making success. Overall, our results suggest that research on decision-making competence would benefit by expanding the definition of competence, by including decision-related abilities in terms of social skills and time-approach. Finally, the results also indicate that individual differences in real-life decision-making success profitably can be approached and measured by different criteria.

  1. Real-Life Research: Project Runway Makeover Model

    Science.gov (United States)

    Jaeger, Paige; Nesi, Olga M.

    2014-01-01

    Real-life research is incredibly varied. We research cars. We research lawn problems. We research child behavior problems, health issues, possible vacation destinations, and prices to stretch our budgets. No two scenarios are ever alike, and no two health issues should be assumed to be the same. That is reality, and that is a picture of what the…

  2. Clinical and economic impact of etanercept in real-life

    DEFF Research Database (Denmark)

    Larsen, Christian Grønhøj; Andersen, Peter Hundevadt; Lorentzen, Henrik

    2013-01-01

    BACKGROUND: Real-life data on the therapeutic effectiveness and costs of etanercept are scarce. Objectives: To assess the clinical and economic impact of etanercept in patients with psoriasis in Denmark and Norway. MATERIAL & METHODS: This prospective, non-interventional study in a private...

  3. Mathematics and engineering in real life through mathematical competitions

    Science.gov (United States)

    More, M.

    2018-02-01

    We bring out an experience of organizing mathematical competitions that can be used as a medium to motivate the student and teacher minds in new directions of thinking. This can contribute to fostering research, innovation and provide a hands-on experience of mathematical concepts with the real world. Mathematical competitions can be used to build curiosity and give an understanding of mathematical applications in real life. Participation in the competition has been classified under four broad categories. Student can showcase their findings in various forms of expression like model, poster, soft presentation, animation, live performance, art and poetry. The basic focus of the competition is on using open source computation tools and modern technology, to emphasize the relationship of mathematical concepts with engineering applications in real life.

  4. Virtually numbed: immersive video gaming alters real-life experience.

    Science.gov (United States)

    Weger, Ulrich W; Loughnan, Stephen

    2014-04-01

    As actors in a highly mechanized environment, we are citizens of a world populated not only by fellow humans, but also by virtual characters (avatars). Does immersive video gaming, during which the player takes on the mantle of an avatar, prompt people to adopt the coldness and rigidity associated with robotic behavior and desensitize them to real-life experience? In one study, we correlated participants' reported video-gaming behavior with their emotional rigidity (as indicated by the number of paperclips that they removed from ice-cold water). In a second experiment, we manipulated immersive and nonimmersive gaming behavior and then likewise measured the extent of the participants' emotional rigidity. Both studies yielded reliable impacts, and thus suggest that immersion into a robotic viewpoint desensitizes people to real-life experiences in oneself and others.

  5. Real-Life Stories About Addiction Struggles | NIH MedlinePlus the Magazine

    Science.gov (United States)

    ... on. Feature: Preventing Drug Abuse and Addiction Real-Life Stories About Addiction Struggles Past Issues / Fall 2011 ... TO PLAY THE VIDEO NIHSeniorHealth Videos Offer Real-Life Stories About Addiction Struggles—and Much More Many ...

  6. Control of asthma in real life: still a valuable goal?

    Directory of Open Access Journals (Sweden)

    Andriana I. Papaioannou

    2015-06-01

    Full Text Available Although studies show that control of asthma can be achieved in the majority of patients, surveys repeatedly show that this is not the case in real life. Important measures to implement in order to achieve asthma control are trained healthcare professionals, a good patient–doctor relationship, patient education, avoidance of exposure to triggers, personalised management and adherence to treatment. These measures help the majority of asthma patients but have not yet been widely implemented and there should be a concerted action for their implementation. Moreover, further and focused research is needed in severe/refractory asthma.

  7. Online Game Player Personality and Real-life Need Fulfillment

    Directory of Open Access Journals (Sweden)

    Ching-I Teng

    2009-12-01

    Full Text Available This study investigates the relationship between personality and real-life need fulfillment of 114 online game adolescent players, who had an average of 14.86 years in age and a standard deviation of 1.40 years. Of the sample, 73.7% were male and 88.8% had a monthly income below US $90. Results indicate that openness negatively correlated to fulfillment of needs for achievement and affiliation. Conscientiousness positively correlated to fulfillment of needs for achievement, affiliation, autonomy, and dominance. Extraversion positively correlated to fulfillment of needs for affiliation and dominance.

  8. Speed Biases With Real-Life Video Clips

    Directory of Open Access Journals (Sweden)

    Federica Rossi

    2018-03-01

    Full Text Available We live almost literally immersed in an artificial visual world, especially motion pictures. In this exploratory study, we asked whether the best speed for reproducing a video is its original, shooting speed. By using adjustment and double staircase methods, we examined speed biases in viewing real-life video clips in three experiments, and assessed their robustness by manipulating visual and auditory factors. With the tested stimuli (short clips of human motion, mixed human-physical motion, physical motion and ego-motion, speed underestimation was the rule rather than the exception, although it depended largely on clip content, ranging on average from 2% (ego-motion to 32% (physical motion. Manipulating display size or adding arbitrary soundtracks did not modify these speed biases. Estimated speed was not correlated with estimated duration of these same video clips. These results indicate that the sense of speed for real-life video clips can be systematically biased, independently of the impression of elapsed time. Measuring subjective visual tempo may integrate traditional methods that assess time perception: speed biases may be exploited to develop a simple, objective test of reality flow, to be used for example in clinical and developmental contexts. From the perspective of video media, measuring speed biases may help to optimize video reproduction speed and validate “natural” video compression techniques based on sub-threshold temporal squeezing.

  9. Accounting Theory: An Ethical Perspective of Real Life Scenarios

    Directory of Open Access Journals (Sweden)

    Shivneil Kumar Raj

    2016-11-01

    Full Text Available Decisions are made daily in businesses and individuals do encounter situations where they are faced with ethical issues. The subject is how one evaluates whether an act is ethical or unethical. This research article discusses real life ethical dilemmas that could be faced in accounting or business environment and applicability of various theories of ethics that were taught in accounting theory course in the undergraduate accounting program. The researcher employs a number of case studies highlighting the stories related to ethics that have been experienced in the past working life. Teleological and deontological theories are being used to explain how one could identify that a particular act is ethical or unethical. The work of accountants requires them to maintain high level of ethics to ensure integrity of the profession.

  10. Temporal compression in episodic memory for real-life events.

    Science.gov (United States)

    Jeunehomme, Olivier; Folville, Adrien; Stawarczyk, David; Van der Linden, Martial; D'Argembeau, Arnaud

    2018-07-01

    Remembering an event typically takes less time than experiencing it, suggesting that episodic memory represents past experience in a temporally compressed way. Little is known, however, about how the continuous flow of real-life events is summarised in memory. Here we investigated the nature and determinants of temporal compression by directly comparing memory contents with the objective timing of events as measured by a wearable camera. We found that episodic memories consist of a succession of moments of prior experience that represent events with varying compression rates, such that the density of retrieved information is modulated by goal processing and perceptual changes. Furthermore, the results showed that temporal compression rates remain relatively stable over one week and increase after a one-month delay, particularly for goal-related events. These data shed new light on temporal compression in episodic memory and suggest that compression rates are adaptively modulated to maintain current goal-relevant information.

  11. Intriguingly Real Life of the Queen of Crime

    Directory of Open Access Journals (Sweden)

    Branka Kovačević

    2016-12-01

    Full Text Available This December it will be ninety years since Agatha Christie disappeared for eleven days and despite the fact that there are many biographical books about her life and work, nobody knows for sure what provoked her to vanish, sending shockwaves in British society in 1926. Whatever the cause may be, this disappearance has remained a mystery and inspired French authors Anne Martinetti and Guillaume Lebeau, along with the illustrator Alexandre Franc, to create a graphic novel: Agatha: The Real Life of Agatha Christie. Marinetti has also written a cookbook inspired by Agatha Christie, entitled Creams and Punishments, while together with Lebeau, she has co-authored the encyclopedia Agatha Christie from A to Z.Agatha: The Real Life of Agatha Christie was originally released in 2014 as a French-language Kindle edition and was first published in English in May, 2016 by the UK press SelfMadeHero, which specializes in graphic novels and manga adaptations of classic literature, like those of Shakespeare, Poe and Kafka. The story is told through 112 illustrated pages and concludes with a thorough timeline of key events in Agatha Christie’s life, as well as a complete bibliography. It is noticeable that novels and story collections featuring Hercule Poirot take up the greater part of her bibliography. The authors of this biography assume a similar approach in showing the significance of this fictional character in Christie's career (and life, representing Poirot throughout the text as her companion and advisor without using any graphic techniques to stress the fictionality of his character. The authors make strong attempts to convey the close relationship that Christie built with her most prominent character, one who always seems to appear in this biography during her moments of extreme loneliness, and one to whom Christie owed a great deal – as she admited herself when she decided to buy the Greenway House in December 1938 (Martinetti, Lebeau, and Franc

  12. "Real life" longevity of implantable cardioverter-defibrillator devices.

    Science.gov (United States)

    Manolis, Antonis S; Maounis, Themistoklis; Koulouris, Spyridon; Vassilikos, Vassilios

    2017-09-01

    Manufacturers of implantable cardioverter-defibrillators (ICDs) promise a 5- to 9-year projected longevity; however, real-life data indicate otherwise. The aim of the present study was to assess ICD longevity among 685 consecutive patients over the last 20 years. Real-life longevity of ICDs may differ from that stated by the manufacturers. The study included 601 men and 84 women (mean age, 63.1 ± 13.3 years). The underlying disease was coronary (n = 396) or valvular (n = 15) disease, cardiomyopathy (n = 220), or electrical disease (n = 54). The mean ejection fraction was 35%. Devices were implanted for secondary (n = 562) or primary (n = 123) prevention. Single- (n = 292) or dual-chamber (n = 269) or cardiac resynchronization therapy (CRT) devices (n = 124) were implanted in the abdomen (n = 17) or chest (n = 668). Over 20 years, ICD pulse generator replacements were performed in 238 patients (209 men; age 63.7 ± 13.9 years; ejection fraction, 37.7% ± 14.0%) who had an ICD for secondary (n = 210) or primary (n = 28) prevention. The mean ICD longevity was 58.3 ± 18.7 months. In 20 (8.4%) patients, devices exhibited premature battery depletion within 36 months. Most (94%) patients had none, minor, or modest use of ICD therapy. Longevity was longest for single-chamber devices and shortest for CRT devices. Latest-generation devices replaced over the second decade lasted longer compared with devices replaced during the first decade. When analyzed by manufacturer, Medtronic devices appeared to have longer longevity by 13 to 18 months. ICDs continue to have limited longevity of 4.9 ± 1.6 years, and 8% demonstrate premature battery depletion by 3 years. CRT devices have the shortest longevity (mean, 3.8 years) by 13 to 17 months, compared with other ICD devices. These findings have important implications, particularly in view of the high expense involved with this type of electrical

  13. "Real-life" treatment of chronic pain: Targets and goals.

    Science.gov (United States)

    Ablin, Jacob N; Buskila, Dan

    2015-02-01

    Treating chronic pain is a complex challenge. While textbooks and medical education classically categorize pain as originating from peripheral (nociceptive), neuropathic, or centralized origins, in real life each and every patient may present a combination of various pain sources, types, and mechanisms. Moreover, individual patients may evolve and develop differing types of pain throughout their clinical follow-up, further emphasizing the necessity to maintain clinical diligence during the evaluation and follow-up of these patients. Rational treatment of patients suffering from chronic pain must attempt at deconstructing complex pain cases, identifying variegate pain generators, and targeting them with appropriate interventions, while incorporating both pharmacological and non-pharmacological strategies, rather than focusing on the total pain level, which represents an integral of all pain types. Failing to recognize the coexistence of different types of pain in an individual patient and escalating medications only on the basis of total pain intensity are liable to lead to both ineffective control of pain and increased untoward effects. In the current review, we outline strategies for deconstructing complex pain and therapeutic suggestions. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Solving Real-Life Problems: Future Mobile Technology Sophistication

    Directory of Open Access Journals (Sweden)

    FARHAN SHAFIQ

    2016-07-01

    Full Text Available Almost all the human being real life concerned domains are taking advantage of latest technologies for enhancing their process, procedures and operations. This integration of technological innovations provides ease of access, flexibility, transparency, reliability and speed for the concerned process and procedures. Rapid growth of ICT (Information and Communication Technology and MT (Mobile Technology provides opportunity to redesign and reengineered the human routines? life activities process and procedures. Technology integration and adoption in routine life activities may serves compensatory mechanism to assist the population in different manner such as monitoring older adults and children at homes, provides security assistance, monitoring and recording patients vital signs automatically, controlling and monitoring equipments and devices, providing assistance in shopping, banking and education as well. Disasters happened suddenly, destroy everything indiscriminately. Adoption and integration of latest technologies including ICT and MT can enhance the current disaster management process, procedures and operations. This research study focuses the impacts of latest and emerging technology trends in routine life activities and surrounds their potential strength to improve and enhance disaster management activities. MT is providing a promising platform for facilitating people to enhance their routine life activities. This research argue that integration and adoption of mobile computing in disaster management domain can enhance disaster management activities with promising minimizing error, quick information assembling, quick response based on technology manipulation and prioritizing action.

  15. Safety and efficacy of venom immunotherapy: a real life study.

    Science.gov (United States)

    Kołaczek, Agnieszka; Skorupa, Dawid; Antczak-Marczak, Monika; Kuna, Piotr; Kupczyk, Maciej

    2017-04-01

    Venom immunotherapy (VIT) is recommended as the first-line treatment for patients allergic to Hymenoptera venom. To analyze the safety and efficacy of VIT in a real life setting. One hundred and eighty patients undergoing VIT were studied to evaluate the safety, efficacy, incidence and nature of symptoms after field stings and adverse reactions to VIT. Significantly more patients were allergic to wasp than bee venom (146 vs. 34, p bees, and were not associated with angiotensin convertase inhibitors (ACEi) or β-adrenergic antagonists use. Systemic reactions were observed in 4 individuals on wasp VIT (2.7%) and in 6 patients allergic to bees (17.65%). The VIT was efficacious as most patients reported no reactions (50%) or reported only mild local reactions (43.75%) to field stings. The decrease in sIgE at completion of VIT correlated with the dose of vaccine received ( r = 0.53, p = 0.004). Beekeeping (RR = 29.54, p venom allergy. Venom immunotherapy is highly efficacious and safe as most of the adverse events during the induction and maintenance phase are mild and local. Side effects of VIT are more common in subjects on bee VIT. Beekeeping and female sex are associated with a higher risk of allergy to Hymenoptera venom.

  16. Solving real-life problems: future mobile technology sophistication

    International Nuclear Information System (INIS)

    Shafiq, F.; Ahsan, K.; Nadeem, A.

    2016-01-01

    Almost all the human being real life concerned domains are taking advantage of latest technologies for enhancing their process, procedures and operations. This integration of technological innovations provides ease of access, flexibility, transparency, reliability and speed for the concerned process and procedures. Rapid growth of ICT (Information and Communication Technology) and MT (Mobile Technology) provides opportunity to redesign and re-engineered the human routines life activities process and procedures. Technology integration and adoption in routine life activities may serves compensatory mechanism to assist the population in different manner such as monitoring older adults and children at homes, provides security assistance, monitoring and recording patients vital signs automatically, controlling and monitoring equipments and devices, providing assistance in shopping, banking and education as well. Disasters happened suddenly, destroy everything indiscriminately. Adoption and integration of latest technologies including ICT and MT can enhance the current disaster management process, procedures and operations. This research study focuses the impacts of latest and emerging technology trends in routine life activities and surrounds their potential strength to improve and enhance disaster management activities. MT is providing a promising platform for facilitating people to enhance their routine life activities. This research argue that integration and adoption of mobile computing in disaster management domain can enhance disaster management activities with promising minimizing error, quick information assembling, quick response based on technology manipulation and prioritizing action. (author)

  17. Real life testing of a Hybrid PEM Fuel Cell Bus

    Science.gov (United States)

    Folkesson, Anders; Andersson, Christian; Alvfors, Per; Alaküla, Mats; Overgaard, Lars

    Fuel cells produce low quantities of local emissions, if any, and are therefore one of the most promising alternatives to internal combustion engines as the main power source in future vehicles. It is likely that urban buses will be among the first commercial applications for fuel cells in vehicles. This is due to the fact that urban buses are highly visible for the public, they contribute significantly to air pollution in urban areas, they have small limitations in weight and volume and fuelling is handled via a centralised infrastructure. Results and experiences from real life measurements of energy flows in a Scania Hybrid PEM Fuel Cell Concept Bus are presented in this paper. The tests consist of measurements during several standard duty cycles. The efficiency of the fuel cell system and of the complete vehicle are presented and discussed. The net efficiency of the fuel cell system was approximately 40% and the fuel consumption of the concept bus is between 42 and 48% lower compared to a standard Scania bus. Energy recovery by regenerative braking saves up 28% energy. Bus subsystems such as the pneumatic system for door opening, suspension and brakes, the hydraulic power steering, the 24 V grid, the water pump and the cooling fans consume approximately 7% of the energy in the fuel input or 17% of the net power output from the fuel cell system. The bus was built by a number of companies in a project partly financed by the European Commission's Joule programme. The comprehensive testing is partly financed by the Swedish programme "Den Gröna Bilen" (The Green Car). A 50 kW el fuel cell system is the power source and a high voltage battery pack works as an energy buffer and power booster. The fuel, compressed hydrogen, is stored in two high-pressure stainless steel vessels mounted on the roof of the bus. The bus has a series hybrid electric driveline with wheel hub motors with a maximum power of 100 kW. Hybrid Fuel Cell Buses have a big potential, but there are

  18. Learning based upon projects of architectural conservation: from university to real life

    OpenAIRE

    Mileto, Camilla; Vegas López-Manzanares, Fernando; Cristini, Valentina; Diodato, Maria

    2011-01-01

    Mileto, C.; Vegas López-Manzanares, F.; Cristini, V.; Diodato, M. (2011). Learning based upon projects of architectural conservation: from university to real life. IATED. 1-8. http://hdl.handle.net/10251/50072 Senia 1 8

  19. Social Anxiety in Online and Real-Life Interaction and Their Associated Factors

    OpenAIRE

    Yen, Ju-Yu; Yen, Cheng-Fang; Chen, Cheng-Sheng; Wang, Peng-Wei; Chang, Yi-Hsin; Ko, Chih-Hung

    2012-01-01

    Social anxiety was compared between online and real-life interaction in a sample of 2,348 college students. Severity of social anxiety in both real-life and online interaction was tested for associations with depression, Internet addiction, Internet activity type (gaming versus chatting), and scores on Behavioral Inhibition System (BIS)/Behavioral Activation System (BAS) scales. The results showed that social anxiety was lower when interacting online than when interacting offline. Depression,...

  20. In Patients with Cirrhosis, Driving Simulator Performance is Associated With Real-life Driving

    DEFF Research Database (Denmark)

    Lauridsen, Mette Enok Munk; Thacker, Leroy R; White, Melanie B

    2016-01-01

    BACKGROUND & AIMS: Minimal hepatic encephalopathy (MHE) has been linked to higher real-life rates of automobile crashes and poor performance in driving simulation studies, but the link between driving simulator performance and real-life automobile crashes has not been clearly established. Further......, not all patients with MHE are unsafe drivers, but it is unclear how to distinguish them from unsafe drivers. We investigated the link between performance on driving simulators and real-life automobile accidents and traffic violations. We also aimed to identify features of unsafe drivers with cirrhosis...... and evaluated changes in simulated driving skills and MHE status after 1 year. METHODS: We performed a study of outpatients with cirrhosis (n=205; median 55 years old; median model for end-stage liver disease score, 9.5; none with overt hepatic encephalopathy or alcohol or illicit drug use within previous 6...

  1. High correlation between performance on a virtual-reality simulator and real-life cataract surgery

    DEFF Research Database (Denmark)

    Thomsen, Ann Sofia Skou; Smith, Phillip; Subhi, Yousif

    2017-01-01

    -tracking software of cataract surgical videos with a Pearson correlation coefficient of -0.70 (p = 0.017). CONCLUSION: Performance on the EyeSi simulator is significantly and highly correlated to real-life surgical performance. However, it is recommended that performance assessments are made using multiple data......PURPOSE: To investigate the correlation in performance of cataract surgery between a virtual-reality simulator and real-life surgery using two objective assessment tools with evidence of validity. METHODS: Cataract surgeons with varying levels of experience were included in the study. All...... antitremor training, forceps training, bimanual training, capsulorhexis and phaco divide and conquer. RESULTS: Eleven surgeons were enrolled. After a designated warm-up period, the proficiency-based test on the EyeSi simulator was strongly correlated to real-life performance measured by motion...

  2. Emotional and Physiological Desensitization to Real-Life and Movie Violence

    Science.gov (United States)

    Mrug, Sylvie; Madan, Anjana; Cook, Edwin W.; Wright, Rex A.

    2014-01-01

    Youth are exposed to large amounts of violence in real life and media, which may lead to desensitization. Given evidence of curvilinear associations between exposure to violence and emotional distress, we examined linear and curvilinear associations of exposure to real-life and movie violence with PTSD symptoms, empathy, and physiological arousal, as well emotional and physiological reactivity to movie violence. College students (N=209; mean age=18.74) reported on their exposure to real-life and televised violence, PTSD symptoms, and empathy. Then, students were randomly assigned to view a series of violent or nonviolent high-action movie scenes, providing ratings of emotional distress after each clip. Blood pressure was measured at rest and during video viewing. Results showed that with increasing exposure to real-life violence, youth reported more PTSD symptoms and greater identification with fictional characters. Cognitive and emotional empathy increased from low to medium levels of exposure to violence, but declined at higher levels. For males, exposure to higher levels of real-life violence was associated with diminishing (vs. increasing) emotional distress when viewing violent videos. Exposure to televised violence was generally unrelated to emotional functioning. However, those with medium levels of exposure to TV/movie violence experienced lower elevations of blood pressure when viewing violent videos compared to those with low exposure, and those with higher levels of exposure evidenced rapid increase in blood pressure that quickly declined over time. The results point to diminished empathy and reduced emotional reactivity to violence as key aspects of desensitization to real-life violence, and more limited evidence of physiological desensitization to movie violence among those exposed to high levels of televised violence. PMID:25326900

  3. How Accumulated Real Life Stress Experience and Cognitive Speed Interact on Decision-Making Processes.

    Science.gov (United States)

    Friedel, Eva; Sebold, Miriam; Kuitunen-Paul, Sören; Nebe, Stephan; Veer, Ilya M; Zimmermann, Ulrich S; Schlagenhauf, Florian; Smolka, Michael N; Rapp, Michael; Walter, Henrik; Heinz, Andreas

    2017-01-01

    Rationale: Advances in neurocomputational modeling suggest that valuation systems for goal-directed (deliberative) on one side, and habitual (automatic) decision-making on the other side may rely on distinct computational strategies for reinforcement learning, namely model-free vs. model-based learning. As a key theoretical difference, the model-based system strongly demands cognitive functions to plan actions prospectively based on an internal cognitive model of the environment, whereas valuation in the model-free system relies on rather simple learning rules from operant conditioning to retrospectively associate actions with their outcomes and is thus cognitively less demanding. Acute stress reactivity is known to impair model-based but not model-free choice behavior, with higher working memory capacity protecting the model-based system from acute stress. However, it is not clear which impact accumulated real life stress has on model-free and model-based decision systems and how this influence interacts with cognitive abilities. Methods: We used a sequential decision-making task distinguishing relative contributions of both learning strategies to choice behavior, the Social Readjustment Rating Scale questionnaire to assess accumulated real life stress, and the Digit Symbol Substitution Test to test cognitive speed in 95 healthy subjects. Results: Individuals reporting high stress exposure who had low cognitive speed showed reduced model-based but increased model-free behavioral control. In contrast, subjects exposed to accumulated real life stress with high cognitive speed displayed increased model-based performance but reduced model-free control. Conclusion: These findings suggest that accumulated real life stress exposure can enhance reliance on cognitive speed for model-based computations, which may ultimately protect the model-based system from the detrimental influences of accumulated real life stress. The combination of accumulated real life stress exposure

  4. Efficient and Flexible KNN Query Processing in Real-Life Road Networks

    DEFF Research Database (Denmark)

    Lu, Yang; Bui, Bin; Zhao, Jiakui

    2008-01-01

    are included into the RNG index, which enables the index to support both distance-based and time-based KNN queries and continuous KNN queries. Our work extends previous ones by taking into account more practical scenarios, such as complexities in real-life road networks and time-based KNN queries. Extensive......Along with the developments of mobile services, effectively modeling road networks and efficiently indexing and querying network constrained objects has become a challenging problem. In this paper, we first introduce a road network model which captures real-life road networks better than previous...

  5. Creating Machinima (3D) and Real Life Videos in an ESP Classroom

    Science.gov (United States)

    Ochoa Alpala, Carol Anne; Ortíz García, William Ricardo

    2018-01-01

    This research paper reports on the development of oral presentation skills in a 3D virtual world called "Moviestorm" machinima, in contrast with real-life videos. In this way, the implementation of both types of videos sought to promote the improvement of oral communication skills, specifically oral presentations in a foreign language,…

  6. A novel dataset for real-life evaluation of facial expression recognition methodologies

    NARCIS (Netherlands)

    Siddiqi, Muhammad Hameed; Ali, Maqbool; Idris, Muhammad; Banos Legran, Oresti; Lee, Sungyoung; Choo, Hyunseung

    2016-01-01

    One limitation seen among most of the previous methods is that they were evaluated under settings that are far from real-life scenarios. The reason is that the existing facial expression recognition (FER) datasets are mostly pose-based and assume a predefined setup. The expressions in these datasets

  7. Center for Real Life Kitchen Design open house to showcase latest in residential kitchens

    OpenAIRE

    Elliott, Jean

    2007-01-01

    Virginia Tech will unveil its newly refurbished Center for Real Life Kitchen Design at an open house set for Monday, April 2. The 1,500-square foot center, located in 247 Wallace Hall, features six fully functional residential kitchen designs that reflect a variety of price levels, lifestyles, and use of space for today's homeowner.

  8. Reperfusion Treatment for STEMI in Age Over 75 Years: Unsatisfactory Real-Life Practice

    Czech Academy of Sciences Publication Activity Database

    Monhart, Z.; Grünfeldová, H.; Zvárová, Jana; Janský, P.

    2010-01-01

    Roč. 122, č. 2 (2010), e69 ISSN 0009-7322. [World Congress of Cardiology . 16.06.2010-19.06.2010, Beijing] Institutional research plan: CEZ:AV0Z10300504 Keywords : cardiology * reperfusion treatment * real-life practice Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery

  9. The Oral Language Process in Writing: A Real-Life Writing Session.

    Science.gov (United States)

    Shuy, Roger W.; Robinson, David G.

    1990-01-01

    Analyzes a real-life writing session involving a male executive in the construction business, his female secretary, and a male representing himself as a state official, working collaboratively to write a letter to a state official urging action on a long overdue claim. Discusses the quality of the drafts and the participants' roles. (KEH)

  10. Genetic influence on blood pressure measured in the office, under laboratory stress and during real life

    NARCIS (Netherlands)

    Wang, Xiaoling; Ding, Xiuhua; Su, Shaoyong; Harshfield, Gregory; Treiber, Frank; Snieder, Harold

    To determine to what extent the genetic influences on blood pressure (BP) measured in the office, under psychologically stressful conditions in the laboratory and during real life are different from each other. Office BP, BP during a video game challenge and a social stressor interview, and 24-h

  11. Group Creativity Development by Solving Real-life Project in Engineering Education

    DEFF Research Database (Denmark)

    Zhou, Chunfang; Kolmos, Anette; Du, Xiangyun

    2011-01-01

    In recent years, problem and project based learning (PBL) has been employed by a growing number of educational institutions to foster creative engineers. Among the diverse pedagogical practices of PBL, there has been an emergence of real-life project for students. Based on literature of creativity...... along with the learning activities etc., which are necessary for group creativity development in engineering students....

  12. Violence exposure in real-life, video games, television, movies, and the internet: is there desensitization?

    Science.gov (United States)

    Funk, Jeanne B; Baldacci, Heidi Bechtoldt; Pasold, Tracie; Baumgardner, Jennifer

    2004-02-01

    It is believed that repeated exposure to real-life and to entertainment violence may alter cognitive, affective, and behavioral processes, possibly leading to desensitization. The goal of the present study was to determine if there are relationships between real-life and media violence exposure and desensitization as reflected in related characteristics. One hundred fifty fourth and fifth graders completed measures of real-life violence exposure, media violence exposure, empathy, and attitudes towards violence. Regression analyses indicated that only exposure to video game violence was associated with (lower) empathy. Both video game and movie violence exposure were associated with stronger proviolence attitudes. The active nature of playing video games, intense engagement, and the tendency to be translated into fantasy play may explain negative impact, though causality was not investigated in the present design. The samples' relatively low exposure to real-life violence may have limited the identification of relationships. Although difficult to quantify, desensitization to violence should be further studied using related characteristics as in the present study. Individual differences and causal relationships should also be examined.

  13. The Forms and Functions of Real-Life Moral Decision-Making.

    Science.gov (United States)

    Krebs, Dennis L.; Denton, Kathy; Wark, Gillian

    1997-01-01

    Observes that the Kohlbergian model of morality does not give a good account of the ways in which people make moral decisions in their everyday lives. Argues that a functional model of moral judgment and moral behavior derived from evolutionary theory may supply a better account of real-life morality. (DSK)

  14. Engineers and the Web: An analysis of real life gaps in information usage

    NARCIS (Netherlands)

    Kraaijenbrink, Jeroen

    2007-01-01

    Engineers face a wide range of gaps when trying to identify, acquire, and utilize information from the Web. To be able to avoid creating such gaps, it is essential to understand them in detail. This paper reports the results of a study of the real life gaps in information usage processes of 17

  15. [The influences of interaction during online gaming on sociability and aggression in real life].

    Science.gov (United States)

    Fuji, Kei; Yoshida, Fujio

    2010-02-01

    This study examined the influences of online gaming on sociability and aggression in real life. It was hypothesized that the effects of online gaming would differ depending on the interaction style of the online-gamers. Online-gamers in Japan (n = 1 477) were asked to respond to questionnaires that measured interaction style during online gaming, the effects of sociability and aggression, as well as social and individual orientation in real life. Factor analysis of the scores for interaction style extracted five factors. Covariance structure analysis indicated that sociable interactions such as "Broadening relations" and "Feeling of belonging" promoted sociability in real life. In addition, "Release from daily hassles" promoted sociability and decreased aggression. In contrast, non-sociable and aggressive interactions decreased sociability and increased aggression. The results also suggested that a social orientation in real life promoted sociable interactions during game playing, while an individual orientation promoted non-sociable and aggressive interactions. These results supported the hypotheses and suggested that online gaming resulted in positive outcomes for those who are socially, but negative outcomes for those who are not.

  16. An adaptation framework for turning Real-Life Events into Games

    DEFF Research Database (Denmark)

    Kjærhus Therkildsen, Sacha; Cassøe Bunkenborg, Nanna; Larsen, Lasse Juel

    method and participatory design to achieve our ambition. In conclusion we found that a framework for persuasive board games can be advanced by balancing five interrelated layers: 1) real life events (game fiction), 2) rules (formal game elements), 3) movement system (game mechanisms), 4) destiny...

  17. Emotional Creativity and Real-Life Involvement in Different Types of Creative Leisure Activities

    Science.gov (United States)

    Trnka, Radek; Zahradnik, Martin; Kuška, Martin

    2016-01-01

    The role of emotional creativity in practicing creative leisure activities and in the preference of college majors remains unknown. This study aims to explore how emotional creativity measured by the Emotional Creativity Inventory (ECI; Averill, 1999) is interrelated with the real-life involvement in different types of specific creative leisure…

  18. Metacognition in Real Life Situations and Study Skills and Habits: Two Types of Processes

    Science.gov (United States)

    Al-Hilawani, Yasser A.

    2016-01-01

    The relationship between metacognition in real life situations and study skills and habits was examined using a sample of college students. Results showed no significant relationship between these two variables nor was there a significant relationship between study skills and reaction time as measured on the metacognitive test. However, there was…

  19. Children with Imaginary Companions Focus on Mental Characteristics When Describing Their Real-life Friends

    Science.gov (United States)

    Davis, Paige E.; Meins, Elizabeth; Fernyhough, Charles

    2014-01-01

    Relations between having an imaginary companion (IC) and (i) descriptions of a real-life friend, (ii) theory of mind performance, and (iii) reported prosocial behaviour and behavioural difficulties were investigated in a sample of 5-year-olds (N?=?159). Children who had an IC were more likely than their peers without an IC to describe their best…

  20. Quality of bystander cardiopulmonary resuscitation during real-life out-of-hospital cardiac arrest

    DEFF Research Database (Denmark)

    Gyllenborg, Tore; Granfeldt, Asger; Lippert, Freddy

    2017-01-01

    BACKGROUND: Cardiopulmonary resuscitation (CPR) can increase survival in out-of-hospital cardiac arrest (OHCA). However, little is known about bystander CPR quality in real-life OHCA. AIM: To describe bystander CPR quality based on automated external defibrillator (AED) CPR process data during OH...

  1. Development of a diagnostic decision tree for obstructive pulmonary diseases based on real-life data

    NARCIS (Netherlands)

    Metting, Esther I; In 't Veen, Johannes C C M; Dekhuijzen, P N Richard; van Heijst, Ellen; Kocks, Janwillem W H; Muilwijk-Kroes, Jacqueline B; Chavannes, Niels H; van der Molen, Thys

    2016-01-01

    The aim of this study was to develop and explore the diagnostic accuracy of a decision tree derived from a large real-life primary care population. Data from 9297 primary care patients (45% male, mean age 53±17 years) with suspicion of an obstructive pulmonary disease was derived from an

  2. How 4 Colleges Take on Veterans' Issues, in Research and Real Life

    Science.gov (United States)

    Sander, Libby

    2012-01-01

    This article features four colleges and how they take on veterans' issues in research and real life. These colleges are (1) Syracuse University; (2) Purdue University; (3) University of Southern California; and (4) University of North Carolina at Chapel Hill. Last year Syracuse established the Institute for Veterans and Military Families to focus…

  3. Moral Emotions and Moral Judgments in Children's Narratives: Comparing Real-Life and Hypothetical Transgressions

    Science.gov (United States)

    Gutzwiller-Helfenfinger, Eveline; Gasser, Luciano; Malti, Tina

    2010-01-01

    How children make meaning of their own social experiences in situations involving moral issues is central to their subsequent affective and cognitive moral learning. Our study of young children's narratives describing their interpersonal conflicts shows that the emotions and judgments constructed in the course of these real-life narratives differ…

  4. Real-life data for the optimization of the geometric layout of an intersection

    NARCIS (Netherlands)

    Fleuren, S.T.G.; Lefeber, A.A.J.

    2016-01-01

    This document contains the data of ten real-life intersections. This data can be used for the optimization of the geometric layout of the intersection, e.g., optimizing the arrival lanes, departure lanes and lane markings at the intersection.

  5. Ambiguity and risk measures in the lab and students’ real-life borrowing behavior

    NARCIS (Netherlands)

    Fairley, Kim; Weitzel, Utz

    This study analyzes the external validity of experimentally elicited ambiguity aversion, likelihood insensitivity and risk aversion on real-life decision-making in the field of student loans. Our main finding is that ambiguity aversion, likelihood insensitivity and risk aversion are not related to

  6. Real-Life Challenges in Using Augmentative and Alternative Communication by Persons with Amyotrophic Lateral Sclerosis

    Science.gov (United States)

    Ray, Jayanti

    2015-01-01

    Given the linguistic and cognitive demands of communication, adult Augmentative and Alternative Communication (AAC) users with acquired communication disorders may have difficulty using AAC systems consistently and effectively in "real-life" situations. The process of recommending AAC systems and strategies is an area of exploration,…

  7. Communication patterns and satisfaction levels in three-dimensional versus real-life intimate relationships.

    Science.gov (United States)

    Gilbert, Richard L; Murphy, Nora A; Ávalos, M Clementina

    2011-10-01

    The present study compared communication patterns and satisfaction levels between three-dimensional (3D) and real-life intimate relationships using a sample of 71 participants who were concurrently involved in an intimate relationship within Second Life and a separate real-life romantic relationship. Participants indicated that the quality of their communication was significantly better in their Second-Life relationship and that they experienced higher levels of satisfaction with their virtual partners. The more positive or idealized view of the 3D relationships may have been due to higher levels of focused interaction and reduced stressors in the virtual world and the greater length, and associated problems, in participant's real-life relationships. In addition, the presence of a concurrent relationship within Second Life could have negatively affected participant's judgments of their real-life relationships. These data offer the first detailed assessment of communication patterns and satisfaction levels in intimate relationships across the real and 3D virtual realms as the number of users and romantic partners in immersive virtual environments continue to grow.

  8. The Use of a Real Life Simulated Problem Based Learning Activity in a Corporate Environment

    Science.gov (United States)

    Laurent, Mark A.

    2013-01-01

    This narrative study examines using a real life simulated problem base learning activity during education of clinical staff, which is expected to design and develop clinically correct electronic charting systems. Expertise in healthcare does not readily transcend to the realm of manipulating software to collect patient data that is pertinent to…

  9. Bringing Reality into Calculus Classrooms: Mathematizing a Real-life Problem Simulated in a Virtual Environment

    Directory of Open Access Journals (Sweden)

    Olga V. Shipulina

    2013-01-01

    Full Text Available The study explores how students, who had completed the AP calculus course, mathematized the optimal navigation real-life problem simulated in the Second Life Virtual Environment. The particular research interest was to investigate whether/how students’ empirical activity in VE influences the way of their mathematizing.

  10. A Real-Life Case Study of Audit Interactions--Resolving Messy, Complex Problems

    Science.gov (United States)

    Beattie, Vivien; Fearnley, Stella; Hines, Tony

    2012-01-01

    Real-life accounting and auditing problems are often complex and messy, requiring the synthesis of technical knowledge in addition to the application of generic skills. To help students acquire the necessary skills to deal with these problems effectively, educators have called for the use of case-based methods. Cases based on real situations (such…

  11. AVEC 2017 - Real-life depression, and affect recognition workshop and challenge

    NARCIS (Netherlands)

    Ringeval, Fabien; Schuller, Bjorn; Valstar, Michel; Gratch, Jonathan; Cowie, Roddy; Scherer, Stefan; Mozgai, Sharon; Cummins, Nicholas; Schmitt, Maximilian; Pantic, Maja

    2017-01-01

    The Audio/Visual Emotion Challenge and Workshop (AVEC 2017) "Real-life depression, and affect" will be the seventh competition event aimed at comparison of multimedia processing and machine learning methods for automatic audiovisual depression and emotion analysis, with all participants competing

  12. Contextualizing Performances: Comparing Performances during TOEFL iBT™ and Real-Life Academic Speaking Activities

    Science.gov (United States)

    Brooks, Lindsay; Swain, Merrill

    2014-01-01

    In this study we compare test takers' performance on the Speaking section of the TOEFL iBT™and their performances during their real-life academic studies. Thirty international graduate students from mixed language backgrounds in two different disciplines (Sciences and Social Sciences) responded to two independent and four integrated speaking tasks…

  13. How Accumulated Real Life Stress Experience and Cognitive Speed Interact on Decision-Making Processes

    Directory of Open Access Journals (Sweden)

    Eva Friedel

    2017-06-01

    Full Text Available Rationale: Advances in neurocomputational modeling suggest that valuation systems for goal-directed (deliberative on one side, and habitual (automatic decision-making on the other side may rely on distinct computational strategies for reinforcement learning, namely model-free vs. model-based learning. As a key theoretical difference, the model-based system strongly demands cognitive functions to plan actions prospectively based on an internal cognitive model of the environment, whereas valuation in the model-free system relies on rather simple learning rules from operant conditioning to retrospectively associate actions with their outcomes and is thus cognitively less demanding. Acute stress reactivity is known to impair model-based but not model-free choice behavior, with higher working memory capacity protecting the model-based system from acute stress. However, it is not clear which impact accumulated real life stress has on model-free and model-based decision systems and how this influence interacts with cognitive abilities.Methods: We used a sequential decision-making task distinguishing relative contributions of both learning strategies to choice behavior, the Social Readjustment Rating Scale questionnaire to assess accumulated real life stress, and the Digit Symbol Substitution Test to test cognitive speed in 95 healthy subjects.Results: Individuals reporting high stress exposure who had low cognitive speed showed reduced model-based but increased model-free behavioral control. In contrast, subjects exposed to accumulated real life stress with high cognitive speed displayed increased model-based performance but reduced model-free control.Conclusion: These findings suggest that accumulated real life stress exposure can enhance reliance on cognitive speed for model-based computations, which may ultimately protect the model-based system from the detrimental influences of accumulated real life stress. The combination of accumulated real life

  14. In Patients With Cirrhosis, Driving Simulator Performance Is Associated With Real-life Driving.

    Science.gov (United States)

    Lauridsen, Mette M; Thacker, Leroy R; White, Melanie B; Unser, Ariel; Sterling, Richard K; Stravitz, Richard T; Matherly, Scott; Puri, Puneet; Sanyal, Arun J; Gavis, Edith A; Luketic, Velimir; Siddiqui, Muhammad S; Heuman, Douglas M; Fuchs, Michael; Bajaj, Jasmohan S

    2016-05-01

    Minimal hepatic encephalopathy (MHE) has been linked to higher real-life rates of automobile crashes and poor performance in driving simulation studies, but the link between driving simulator performance and real-life automobile crashes has not been clearly established. Furthermore, not all patients with MHE are unsafe drivers, but it is unclear how to distinguish them from unsafe drivers. We investigated the link between performance on driving simulators and real-life automobile accidents and traffic violations. We also aimed to identify features of unsafe drivers with cirrhosis and evaluated changes in simulated driving skills and MHE status after 1 year. We performed a study of outpatients with cirrhosis (n = 205; median 55 years old; median model for end-stage liver disease score, 9.5; none with overt hepatic encephalopathy or alcohol or illicit drug use within previous 6 months) seen at the Virginia Commonwealth University and McGuire Veterans Administration Medical Center, from November 2008 through April 2014. All participants were given paper-pencil tests to diagnose MHE (98 had MHE; 48%), and 163 patients completed a standardized driving simulation. Data were collected on traffic violations and automobile accidents from the Virginia Department of Motor Vehicles and from participants' self-assessments when they entered the study, and from 73 participants 1 year later. Participants also completed a questionnaire about alcohol use and cessation patterns. The driving simulator measured crashes, run-time, road center and edge excursions, and illegal turns during navigation; before and after each driving simulation session, patients were asked to rate their overall driving skills. Drivers were classified as safe or unsafe based on crashes and violations reported on official driving records; simulation results were compared with real-life driving records. Multivariable regression analyses of real-life crashes and violations was performed using data on

  15. Can virtual reality exposure therapy gains be generalized to real life? A meta-analysis of studies applying behavioral assessments

    NARCIS (Netherlands)

    Morina, N.; Ijntema, H.; Meyerbröker, K.; Emmelkamp, P.M.G.

    2015-01-01

    In virtual reality exposure therapy (VRET), patients are exposed to virtual environments that resemble feared real-life situations. The aim of the current study was to assess the extent to which VRET gains can be observed in real-life situations. We conducted a meta-analysis of clinical trials

  16. Social Anxiety in Online and Real-Life Interaction and Their Associated Factors

    Science.gov (United States)

    Yen, Ju-Yu; Yen, Cheng-Fang; Chen, Cheng-Sheng; Wang, Peng-Wei; Chang, Yi-Hsin

    2012-01-01

    Abstract Social anxiety was compared between online and real-life interaction in a sample of 2,348 college students. Severity of social anxiety in both real-life and online interaction was tested for associations with depression, Internet addiction, Internet activity type (gaming versus chatting), and scores on Behavioral Inhibition System (BIS)/Behavioral Activation System (BAS) scales. The results showed that social anxiety was lower when interacting online than when interacting offline. Depression, Internet addiction, and high BIS and BAS scores were associated with high social anxiety. The social anxiety decreased more in online interaction among subjects with high social anxiety, depression, BIS, and BAS. This result suggests that the Internet has good potential as an alternative medium for delivering interventions for social anxiety. Further, the effect of BIS on social anxiety is decreased in online interaction. More attention should be paid for BIS when the treatment for social anxiety is delivered online. PMID:22175853

  17. Assessing the Value of Real-life Brands in Virtual Worlds

    DEFF Research Database (Denmark)

    Mattsson, Jan; Barnes, Stuart; Hartley, Nicole

    2015-01-01

    World. A key finding is the difficulty in creating emotional brand value in Second Life which has serious implications for the sustainability of current real-life brands in Virtual Worlds. The paper rounds off with conclusions and implications for future research and practice in this very new area.......Virtual Worlds are a significant new market environment for brand-building through experiential customer service interactions. Using value theory, this paper aims to assess the experiential brand value of real-life brands that have moved to the Virtual World of Second Life. A key premise...... is that current brand offerings in Virtual Worlds do not offer consumers adequate experiential value. The results demonstrate both the validity of an axiological approach to examining brand value, and highlight significant problems in consumer perceptions of the experiential value of brands within the Virtual...

  18. Social anxiety in online and real-life interaction and their associated factors.

    Science.gov (United States)

    Yen, Ju-Yu; Yen, Cheng-Fang; Chen, Cheng-Sheng; Wang, Peng-Wei; Chang, Yi-Hsin; Ko, Chih-Hung

    2012-01-01

    Social anxiety was compared between online and real-life interaction in a sample of 2,348 college students. Severity of social anxiety in both real-life and online interaction was tested for associations with depression, Internet addiction, Internet activity type (gaming versus chatting), and scores on Behavioral Inhibition System (BIS)/Behavioral Activation System (BAS) scales. The results showed that social anxiety was lower when interacting online than when interacting offline. Depression, Internet addiction, and high BIS and BAS scores were associated with high social anxiety. The social anxiety decreased more in online interaction among subjects with high social anxiety, depression, BIS, and BAS. This result suggests that the Internet has good potential as an alternative medium for delivering interventions for social anxiety. Further, the effect of BIS on social anxiety is decreased in online interaction. More attention should be paid for BIS when the treatment for social anxiety is delivered online.

  19. The Couplex test cases: models and lessons

    International Nuclear Information System (INIS)

    Bourgeat, A.; Kern, M.; Schumacher, S.; Talandier, J.

    2003-01-01

    The Couplex test cases are a set of numerical test models for nuclear waste deep geological disposal simulation. They are centered around the numerical issues arising in the near and far field transport simulation. They were used in an international contest, and are now becoming a reference in the field. We present the models used in these test cases, and show sample results from the award winning teams. (authors)

  20. A Simple Method for Solving Fully Intuitionistic Fuzzy Real Life Assignment Problem

    OpenAIRE

    Senthil Kumar, P.; Jahir Hussain, R.

    2016-01-01

    In solving real life assignment problem we often face the state of uncertainty as well as hesitation due to various uncontrollable factors. To deal with uncertainty and hesitation many authors have suggested the intuitionistic fuzzy representations for the data. So, in this paper, the authors consider the assignment problem having uncertainty and hesitation in cost/time/profit. They formulate the problem and utilize triangular intuitionistic fuzzy numbers (TIFNs) to deal with uncertainty and ...

  1. Virginia Tech's Center For Real Life Kitchen Design Is A Success!

    OpenAIRE

    Todd, Jane Anne

    2003-01-01

    Explore Your Dream Kitchen, a two-day workshop offered in Virginia Tech's Center for Real Life Kitchen Design, will be offered twice in May to participants who want to learn about planning and designing a kitchen that really meets their needs. Attendees explore and experience kitchens with a wide variety of designs, products, materials, and technologies during this fun and interactive course. Participants are asked to bring plans, ideas, and questions about their homes and kitchens as everyon...

  2. Framing Mass Shootings: Fictional Depictions of Real-life Gun Massacres in American Cinema

    OpenAIRE

    Tryggeseid, Ane Johannessen

    2017-01-01

    This thesis examines the concept of real-life mass shootings and its depiction in American fictional cinema. The issue of mass shootings is a highly controversial subject of discussion, both within the public and political sphere, as it necessarily touches upon rigid perceptions of civil liberties – specifically those of the Second Amendment – which further permeates the field of fictional cinema. As opposed to assessing the issue of mass shootings as a product of a prevailing culture of guns...

  3. Development of a diagnostic decision tree for obstructive pulmonary diseases based on real-life data

    Directory of Open Access Journals (Sweden)

    Esther I. Metting

    2016-01-01

    Full Text Available The aim of this study was to develop and explore the diagnostic accuracy of a decision tree derived from a large real-life primary care population. Data from 9297 primary care patients (45% male, mean age 53±17 years with suspicion of an obstructive pulmonary disease was derived from an asthma/chronic obstructive pulmonary disease (COPD service where patients were assessed using spirometry, the Asthma Control Questionnaire, the Clinical COPD Questionnaire, history data and medication use. All patients were diagnosed through the Internet by a pulmonologist. The Chi-squared Automatic Interaction Detection method was used to build the decision tree. The tree was externally validated in another real-life primary care population (n=3215. Our tree correctly diagnosed 79% of the asthma patients, 85% of the COPD patients and 32% of the asthma–COPD overlap syndrome (ACOS patients. External validation showed a comparable pattern (correct: asthma 78%, COPD 83%, ACOS 24%. Our decision tree is considered to be promising because it was based on real-life primary care patients with a specialist's diagnosis. In most patients the diagnosis could be correctly predicted. Predicting ACOS, however, remained a challenge. The total decision tree can be implemented in computer-assisted diagnostic systems for individual patients. A simplified version of this tree can be used in daily clinical practice as a desk tool.

  4. Development of a diagnostic decision tree for obstructive pulmonary diseases based on real-life data

    Science.gov (United States)

    in ’t Veen, Johannes C.C.M.; Dekhuijzen, P.N. Richard; van Heijst, Ellen; Kocks, Janwillem W.H.; Muilwijk-Kroes, Jacqueline B.; Chavannes, Niels H.; van der Molen, Thys

    2016-01-01

    The aim of this study was to develop and explore the diagnostic accuracy of a decision tree derived from a large real-life primary care population. Data from 9297 primary care patients (45% male, mean age 53±17 years) with suspicion of an obstructive pulmonary disease was derived from an asthma/chronic obstructive pulmonary disease (COPD) service where patients were assessed using spirometry, the Asthma Control Questionnaire, the Clinical COPD Questionnaire, history data and medication use. All patients were diagnosed through the Internet by a pulmonologist. The Chi-squared Automatic Interaction Detection method was used to build the decision tree. The tree was externally validated in another real-life primary care population (n=3215). Our tree correctly diagnosed 79% of the asthma patients, 85% of the COPD patients and 32% of the asthma–COPD overlap syndrome (ACOS) patients. External validation showed a comparable pattern (correct: asthma 78%, COPD 83%, ACOS 24%). Our decision tree is considered to be promising because it was based on real-life primary care patients with a specialist's diagnosis. In most patients the diagnosis could be correctly predicted. Predicting ACOS, however, remained a challenge. The total decision tree can be implemented in computer-assisted diagnostic systems for individual patients. A simplified version of this tree can be used in daily clinical practice as a desk tool. PMID:27730177

  5. Idiopathic pulmonary fibrosis: from clinical trials to real-life experiences

    Directory of Open Access Journals (Sweden)

    Sergio Harari

    2015-09-01

    Full Text Available Randomised controlled clinical trials are fundamental in medicine to develop new effective drugs and new therapeutic regimens and are the strength of evidence-based medicine. These studies allow us to avoid the repetition of misleading experiences that have been reported in the past, where drugs or associations were utilised without compelling evidence and ultimately proven to be ineffective. In recent years, randomised clinical trials have been conducted and concluded for many rare diseases, including idiopathic pulmonary fibrosis. However, clinical trials do not always reflect the real-life scenario. Patients selected for clinical trials present fewer comorbidities, they fall between certain age limits, and the severity of their disease is defined; therefore, they do not always reflect the whole of the population affected by a specific disease. These are the reasons why we also need data that mirror real-life experience. The limitations that these kind of studies present are always several and the studies should be interpreted with caution, although they can fill the important gap between efficacy and effectiveness. In this article, we will review the existing clinical data on real-life treatment of idiopathic pulmonary fibrosis.

  6. Acoustic Coordinated Reset Neuromodulation in a Real Life Patient Population with Chronic Tonal Tinnitus

    Science.gov (United States)

    Hauptmann, Christian; Ströbel, Armin; Williams, Mark; Patel, Nitesh; Wurzer, Hannes; von Stackelberg, Tatjana; Brinkmann, Uwe; Langguth, Berthold; Tass, Peter A.

    2015-01-01

    Purpose. Primary tinnitus has a severe negative influence on the quality of life of a significant portion of the general population. Acoustic coordinated reset neuromodulation is designed to induce a long-lasting reduction of tinnitus symptoms. To test acoustic coordinated reset neuromodulation as a treatment for chronic, tonal tinnitus under real life conditions, an outpatient study “RESET Real Life” was commissioned by ANM GmbH. Herein we present the results of this study. Methods. In a prospective, open-label, nonrandomized, noncontrolled multicenter clinical study with 200 chronic tinnitus patients, tinnitus questionnaire TBF-12 and Global Clinical Improvement-Impression Scale (CGI-I7) are used to study the safety and efficacy of acoustic coordinated reset neuromodulation. 189 patients completed the last 12-month visit, 11 patients dropped out (8 because of nontreatment related reasons; 2 because tinnitus did not change; and 1 because tinnitus got louder). Results. Acoustic coordinated reset neuromodulation caused a statistically and clinically significant decrease in TBF-12 scores as well as in CGI-I7 after 12 months of therapy under real life conditions. There were no persistent adverse events reported that were related to the therapy. Conclusion. The field study “RESET Real Life” provides evidence for safety and efficacy of acoustic coordinated reset neuromodulation in a prospective, open-label, real life setting. PMID:26568958

  7. REAL-LIFE ACTIVITIES: BOOSTING MY STUDENTS’ AWARENESS OF HONESTY IN CREATING GENRE

    Directory of Open Access Journals (Sweden)

    Rr. Dewi Wahyu Mustikasari

    2017-04-01

    Full Text Available My students was strugled to write genre without copypasting sentences or texts from the internet. On the other hand, it was a huge challange for me to teach five big writing classes. Each class consisted of 25-30 students who tended (mostly collecting unoriginal writing works. This paper discusses the real-life activities that can be used to enhance my students’ aweareness of honesty in creating genre. My students must write some genres namely recount, descriptive (optional, spoof (optional, procedure, hortatory (optional and analytical exposition (optional text. I also took some benefits of ICT to equip the learning process. Browsing and experiencing the menu of premierskills.britishcouncil.org were the real-life activities that explore their personal memories to be told as the recount text. Then they defined the feature of one of the menu of the previous website to be informed as the descriptive text. Furthermore, they wrote their personal funny experiences which were related to the Indonesian culture as the spoof text. The procedure text can be produced by exploring the daily activities in the pictures such as how to make a cup of tea/coffee, cook a sunny side-up egg, insert sim card into mobile phone, etc. Next, my students visited the tourism and public places in Salatiga, and they observed the strength and weekness of those places as the production of hortatory or analytical exposition text. The real-life activities were able to foster my students’ awareness of honesty. It was fantastic that my students were able to create the genre honestly.

  8. Rehabilitation in the real-life environment of a shopping mall.

    Science.gov (United States)

    Labbé, Delphine; Poldma, Tiiu; Fichten, Catherine; Havel, Alice; Kehayia, Eva; Mazer, Barbara; McKinley, Patricia; Rochette, Annie; Swaine, Bonnie

    2018-04-01

    The aim of this study was to explore how shopping malls could be used during rehabilitation and to identify the facilitators and barriers to their use. Two focus groups, conducted with 15 rehabilitation professionals from various disciplines and working with people with disabilities of all ages were structured around two topics: (i) The usage of malls for rehabilitation and (ii) Factors that facilitate or limit rehabilitation professionals' use of the mall as an environment for clinical assessment and/or intervention. The thematic analysis revealed that shopping malls were used to achieve several rehabilitation goals targeting physical and cognitive skills, psychological health and socialization. This real-life environment is motivating and helps foster independence and normalization. Factors affecting mall use during rehabilitation included personal factors (e.g. clients' personality and level of readiness) and environmental factors (e.g. clinical context, accessibility of the mall and social attitudes of store owners). Shopping malls may be a relevant rehabilitation assessment and treatment environment that could contribute to optimizing community integration of people with disabilities. Implications for rehabilitation To ensure successful community reintegration, clients could be trained at some point during their rehabilitation, to perform activities in real-life settings, such as a shopping mall. Shopping malls appear to enable the attainment of rehabilitation goals targeting a variety of skills. This real-life environment appears to be motivating and helps foster independence and normalization. Factors felt to affect mall use during rehabilitation include personal factors (e.g. clients' personality and level of readiness) and environmental factors (e.g. clinical context, accessibility of the mall and social attitudes of store owners). The shopping mall may be an untapped resource as it appears to be a relevant rehabilitation assessment and treatment

  9. Electrochemical dehalogenisation of chlorinated aromatics - from model substances to practice-relevant ''real life'' samples

    International Nuclear Information System (INIS)

    Voss, I.; Altrogge, M.; Francke, W.

    1993-01-01

    Building on methods for the dehalogenisation of chlorinated benzoles known from the literature, an investigation was carried out whether polychlorinated biphenyls, dibenzo furane and dibenzo-p-dioxin can be dehalogenated electrochemically. The experiments were carried out with pure substances and transferred to mixed substances (real life samples). The investigations showed that both pure substances and complex mixtures can be dehalogenated without problems. Even in the presence of a clear oil matrix (e.g.: Oil trickled through a deposit), dehalogenisation of the xenobiotica present is possible. First attempts at 'scaling up' show that the method is also suitable in principle, for the disposal of large quantities of contaminated liquids. (BBR) [de

  10. Dried blood spots, valid screening for viral hepatitis and human immunodeficiency virus in real-life

    DEFF Research Database (Denmark)

    Mössner, Belinda K; Staugaard, Benjamin; Jensen, Janne

    2016-01-01

    AIM: To detect chronic hepatitis B (CHB), chronic hepatitis C (CHC) and human immunodeficiency virus (HIV) infections in dried blood spot (DBS) and compare these samples to venous blood sampling in real-life. METHODS: We included prospective patients with known viral infections from drug treatment......, but correctly classified 95% of the anti-HCV-positive patients with chronic and past infections. Anti-HBc and anti-HBS showed low sensitivity in DBS (68% and 42%). CONCLUSION: DBS sampling, combined with an automated analysis system, is a feasible screening method to diagnose chronic viral hepatitis and HIV...

  11. Real/Life: New British Art and the Reception of Contemporary British Art in Japan

    Directory of Open Access Journals (Sweden)

    Kajiya Kenji

    2016-07-01

    Full Text Available This essay explores the ways in which the exhibition Real/Life: New British Art was conceived and received in Japan, where contemporary British art has been shown since the 1960s. Taking place at five museums in the country between 1998 and 1999, the exhibition aimed to showhow British artists in the 1990s struggled with realities, internal and external, but its response was not as satisfactory as was expected. The essay examines the exhibition as a turning point for the transformation of exhibition culture in Japan from nationally themed exhibitions to showcases of contemporary art in the global context.

  12. Speech Recognition in Real-Life Background Noise by Young and Middle-Aged Adults with Normal Hearing

    OpenAIRE

    Lee, Ji Young; Lee, Jin Tae; Heo, Hye Jeong; Choi, Chul-Hee; Choi, Seong Hee; Lee, Kyungjae

    2015-01-01

    Background and Objectives People usually converse in real-life background noise. They experience more difficulty understanding speech in noise than in a quiet environment. The present study investigated how speech recognition in real-life background noise is affected by the type of noise, signal-to-noise ratio (SNR), and age. Subjects and Methods Eighteen young adults and fifteen middle-aged adults with normal hearing participated in the present study. Three types of noise [subway noise, vacu...

  13. Critical Care Nurses Inadequately Assess SAPS II Scores of Very Ill Patients in Real Life

    Directory of Open Access Journals (Sweden)

    Andreas Perren

    2012-01-01

    Full Text Available Background. Reliable ICU severity scores have been achieved by various healthcare workers but nothing is known regarding the accuracy in real life of severity scores registered by untrained nurses. Methods. In this retrospective multicentre audit, three reviewers independently reassessed 120 SAPS II scores. Correlation and agreement of the sum-scores/variables among reviewers and between nurses and the reviewers’ gold standard were assessed globally and for tertiles. Bland and Altman (gold standard—nurses of sum scores and regression of the difference were determined. A logistic regression model identifying risk factors for erroneous assessments was calculated. Results. Correlation for sum scores among reviewers was almost perfect (mean ICC = 0.985. The mean (±SD nurse-registered SAPS II sum score was 40.3±20.2 versus 44.2±24.9 of the gold standard (32 points scores. The lowest agreement was found in high SAPS II tertiles for haemodynamics (k = 0.45–0.51. Conclusions. In real life, nurse-registered SAPS II scores of very ill patients are inaccurate. Accuracy of scores was not associated with nurses’ characteristics.

  14. Mood effects on memory and executive control in a real-life situation.

    Science.gov (United States)

    Lagner, Prune; Kliegel, Matthias; Phillips, Louise H; Ihle, Andreas; Hering, Alexandra; Ballhausen, Nicola; Schnitzspahn, Katharina M

    2015-01-01

    In the laboratory, studies have shown an inconsistent pattern of whether, and how, mood may affect cognitive functions indicating both mood-related enhancement as well as decline. Surprisingly, little is known about whether there are similar effects in everyday life. Hence, the present study aimed to investigate possible mood effects on memory and executive control in a real-life situation. Mood effects were examined in the context of winning in a sports competition. Sixty-one male handball players were tested with an extensive cognitive test battery (comprising memory and executive control) both after winning a match and after training as neutral baseline. Mood differed significantly between the two testing situations, while physiological arousal and motivation were comparable. Results showed lowered performance after the win compared with training in selected cognitive measures. Specifically, short-term and episodic memory performance was poorer following a win, whereas executive control performance was unaffected by condition. Differences in memory disappeared when emotional states after the match were entered as covariates into the initial analyses. Thus, findings suggest mood-related impairments in memory, but not in executive control processes after a positive real-life event.

  15. Images of eyes enhance investments in a real-life public good.

    Directory of Open Access Journals (Sweden)

    Damien Francey

    Full Text Available A key issue in cooperation research is to determine the conditions under which individuals invest in a public good. Here, we tested whether cues of being watched increase investments in an anonymous public good situation in real life. We examined whether individuals would invest more by removing experimentally placed garbage (paper and plastic bottles from bus stop benches in Geneva in the presence of images of eyes compared to controls (images of flowers. We provided separate bins for each of both types of garbage to investigate whether individuals would deposit more items into the appropriate bin in the presence of eyes. The treatment had no effect on the likelihood that individuals present at the bus stop would remove garbage. However, those individuals that engaged in garbage clearing, and were thus likely affected by the treatment, invested more time to do so in the presence of eyes. Images of eyes had a direct effect on behaviour, rather than merely enhancing attention towards a symbolic sign requesting removal of garbage. These findings show that simple images of eyes can trigger reputational effects that significantly enhance on non-monetary investments in anonymous public goods under real life conditions. We discuss our results in the light of previous findings and suggest that human social behaviour may often be shaped by relatively simple and potentially unconscious mechanisms instead of very complex cognitive capacities.

  16. Desiderio e scrittura in "The Real Life of Sebastian Knight" di Vladimir Nabokov

    Directory of Open Access Journals (Sweden)

    Valeria Invernizzi

    2014-12-01

    This paper examines, from a psychoanalytic standpoint, the intersection between identity and writing in the novel The Real Life of Sebastian Knight (1941 by Vladimir Nabokov. In particular, in the wake of Freud and Lacan, the following contribution will take the notions of desire, signifier, and the process of sublimation involved in artistic creation as interpretative devices. The main focus of the analysis will be the relationship between the two half-brothers of the novel, V (the narrator and Sebastian. First, I will show that Sebastian Knight holds the role of the object of desire for the characters who have established a close relationship with him and, in particular, for V. Secondly, the paper will be devoted to the analysis of the trauma experienced by the characters because of Sebastian's death, with a particular focus on the narrator's mourning through writing (the fictional biography we read in the novel; in the end, I will give evidence of the so-called signifier’s fallacy, crucial episodes in which the narrator can experience an insight into the truth of desire. Because of the not negligible question of the fictional paternity of The Real Life and the equally essential matter of V’s ‘stylistic touch’, metaliterary aspects of the novel will also be part of the following reading of the text.

  17. Importance of leadership in cardiac arrest situations: from simulation to real life and back.

    Science.gov (United States)

    Hunziker, Sabnina; Tschan, Franziska; Semmer, Norbert K; Marsch, Stephan

    2013-04-18

    The 2010 American Heart Association guidelines now recommend leadership training in Advanced Cardiac Life Support courses. In this review we provide a comprehensive summary of data derived from clinical studies that investigated the importance of leadership in cardiopulmonary resuscitation (CPR). Only a few, mostly observational, studies have been conducted under real-life conditions because of the high heterogeneity of the situations, difficulties in capturing the initial phase of CPR, and ethical issues. Well-controlled studies in the human simulator can fill existing gaps and provide important insights. High-fidelity video-assisted simulator studies from different research groups have shown that a prolonged process of teambuilding is associated with significant shortcomings in CPR, whereas effective leadership improves team performance. In addition, randomised controlled studies have provided evidence that medical students receiving leadership training subsequently showed improved CPR performance, which was sustained after a follow up of 4 months. In addition, leadership is influenced by gender and other factors such as emotional stress. Future studies are needed to investigate cultural differences and how findings from the simulator can be transferred to real-life situations.

  18. Test case preparation using a prototype

    OpenAIRE

    Treharne, Helen; Draper, J.; Schneider, Steve A.

    1998-01-01

    This paper reports on the preparation of test cases using a prototype within the context of a formal development. It describes an approach to building a prototype using an example. It discusses how a prototype contributes to the testing activity as part of a lifecycle based on the use of formal methods. The results of applying the approach to an embedded avionics case study are also presented.

  19. Overvoltage Protection of Large Power Transformers - A Real-Life Study Case

    DEFF Research Database (Denmark)

    Bak, Claus Leth; Einarsdottir, K. E.; Andresson, E.

    2008-01-01

    This paper demonstrates the results from a detailed study of the overvoltage protection of a particular 400/150-kV 400-MVA power transformer. The work presented here is based on a real-life power system substation design and data and initiated by Danish TSO Energinet.dk as a consequence of serious...... transformer overvoltage damage. A simulation model for the entire system consisting of overhead line, transformer, surge arrester, and earth grid has been created in PSCAD/EMTDC. The main focus has been put on the earth grid, which has been submodeled in detail in MATLAB using an electromagnetic transient...... exceeded. It is clearly illustrated that the transient performance of the earth grid plays an important role in the overall overvoltage protection system design....

  20. Real life experimental determination of platinum group metals content in automotive catalytic converters

    Science.gov (United States)

    Yakoumis, I.; Moschovi, A. M.; Giannopoulou, I.; Panias, D.

    2018-03-01

    The real life experimental protocol for the preparation of spent automobile catalyst samples for elemental analysis is thoroughly described in the following study. Collection, sorting and dismantling, homogenization and sample preparation for X-Ray fluorescence spectroscopy and Atomic Adsorption Spectroscopy combined with Inductive coupled plasma mass spectrometry are discussed in detail for both ceramic and metallic spent catalysts. The concentrations of Platinum Group Metals (PGMs) in spent catalytic converters are presented based on typical consignments of recycled converters (more than 45,000 pieces) from the Greek Market. The conclusions clearly denoted commercial metallic catalytic foil contains higher PGMs loading than ceramic honeycombs. On the other hand, the total PGMs loading in spent ceramic catalytic converters has been found higher than the corresponding value for the metallic ones.

  1. Cyberbullying in Germany – an exploration of prevalence, overlapping with real life bullying and coping strategies

    Directory of Open Access Journals (Sweden)

    JULIA RIEBEL

    2009-09-01

    Full Text Available A new phenomenon of violence among pupils has been spreading over Europe in the last few years: Cyberbullying, the repeated and intended hurting of weaker schoolmates via modern communication technologies. This study shows (based on a sample of 1987 pupils, that cyberbullying exists in Germany, although the number of incidents is still rather small. It could also be shown, that the pupils who act as cyberbullies are the same as those who bully others in real life. The same overlap was found to be true for the victims. Cyberbullying can therefore be considered a subcategory of ordinary bullying instead of being considered a whole new phenomenon. The exploration of coping strategies showed, that a common factor structure underlies physical, verbal and cyberbullying. Considering the fact that the findings of the study are based on an online questionnaire with restricted representativeness, the results should however be interpreted carefully.

  2. Real life narratives enhance learning about the 'art and science' of midwifery practice.

    Science.gov (United States)

    Gilkison, Andrea; Giddings, Lynne; Smythe, Liz

    2016-03-01

    Health professional educators have long grappled with how to teach the more elusive art of practice alongside the science (a term that encompasses the sort of professional knowledge that can be directly passed on). A competent practitioner is one who knows when, how and for whom to apply knowledge and skills, thereby making the links between theory and practice. They combine art and science in such a way that integrates knowledge with insight. This participatory hermeneutic study explored the experience of teachers and students of implementing a narrative-centred curriculum in undergraduate midwifery education. It revealed that when real life narratives were central to the learning environment, students' learning about the art of midwifery practice was enhanced as they learned about midwifery decisions, reflected on their own values and beliefs and felt an emotional connection with the narrator. Further, art and science became melded together in the context specific wisdom of practice (phronesis).

  3. Evaluation of RPL-compliant routing solutions in real-life WSNs

    Directory of Open Access Journals (Sweden)

    Zahariadis Theodore

    2016-01-01

    Full Text Available Wireless Sensor Networks (WSN applications continue to expand and already cover almost all our daily activities improving from security and environmental efficiency to gaming experience. The diverse applications running on top of WSNs have led to the design of an immense number of routing protocols. Few years ago, the IETF standardized the IPv6 routing protocol for low-power and lossy networks (RPL which is based on routing metrics to build communication paths between a source and the destination node. While significant efforts have focused on the design of routing metrics that satisfy the various applications, limited work has been reported on validating their performance using real-life motes. In this paper, we focus on validating the simulation results (obtained through the JSim simulator using TelosB motes for a set of routing metrics that have been proposed in our previous articles.

  4. Chronic urticaria in the real-life clinical practice setting in Sweden, Norway and Denmark

    DEFF Research Database (Denmark)

    Thomsen, S F; Pritzier, E C; Anderson, C D

    2017-01-01

    ]; chronic urticaria quality of life questionnaire [CU-Q2 oL; Danish patients only]) and work productivity and activity impairment (WPAI) scores were also assessed. RESULTS: Overall, 158 CU patients from seven centres in Denmark (n = 80), Norway (n = 50) and Sweden (n = 28) were included in this baseline......BACKGROUND: Chronic urticaria (CU) is characterized by the recurrence of itchy hives and/or angioedema for more than 6 weeks. AWARE (A World-wide Antihistamine-Refractory Chronic Urticaria Patient Evaluation) is a multinational study designed to document the real-life treatment situation, burden...... (>2 months) that is refractory to H1-antihistamines. Baseline patient characteristics, disease activity (urticaria control test [UCT]), pharmacological treatment, comorbidities and healthcare usage were documented by the treating physician. Quality of life (QoL; dermatology life quality index [DLQI...

  5. Real-life decision making in college students. I: Consistency across specific decisions.

    Science.gov (United States)

    Galotti, Kathleen M; Wiener, Hillary J D; Tandler, Jane M

    2014-01-01

    First-year undergraduates participated in a short-term longitudinal study of real-life decision making over their first 14 months of college. They were surveyed about 7 different decisions: choosing courses for an upcoming term (3 different terms), choosing an academic major (twice), planning for the upcoming summer, and planning for sophomore-year housing. Participants showed moderate levels of consistency in the options they considered and in the criteria they used to decide between options, with about half of the options or criteria being used at 2 different points on the decision repeatedly studied. Participants varied somewhat in structural consistency, the tendency to consider the same number of options or criteria across decisions. They also varied in the way they integrated information across decision-making tasks. We suggest that people attempt to keep the information demands of the task within workable limits, sometimes sacrificing consistency as a result.

  6. Can the response to Omalizumab be influenced by treatment duration? A real-life study.

    Science.gov (United States)

    Sposato, Bruno; Scalese, Marco; Latorre, Manuela; Novelli, Federica; Scichilone, Nicola; Milanese, Manlio; Olivieri, Carmela; Perrella, Antonio; Paggiaro, Pierluigi

    2017-06-01

    It is unknown whether Omalizumab effectiveness changes over the course of time. Our retrospective real-life study tried to analyze whether Omalizumab response may be influenced by treatment duration. 340 severe asthmatics treated with Omalizumab for different periods of time were recruited. They were subdivided into 4 groups according to the Omalizumab treatment length: 60 months. Omalizumab treatment results (FEV 1 , exacerbations, ACT, SABA use, asthma control levels, medications used e and ICS doses) were compared. ACT, exacerbations, GINA control levels, ICS doses and SABA use were similar in all groups with different Omalizumab treatment durations. Using a linear regression model, corrected for all confounding variables, a higher significant positive increase in FEV 1 % in subjects treated for 12-24 (β = 9.49; p = 0.034) or 24-60 months (β = 8.56; p = 0.043) was found when compared with subjects treated for a shorter period. Treatment duration was positively associated with a step down of the other associated therapies (OR: 1.013; p = 0.019). This association was more relevant (OR: 4.167; p = 0.005) when we considered Omalizumab treatment duration >60 months compared to the shorter therapy. In particular, the percentage of subjects that were taking Montelukast, LABAs and oral corticosteroids was lower in the group treated with Omalizumab for a longer period of time. In real-life, the positive Omalizumab response remained stable for over 60 months. Long term Omalizumab treatment may lead to a discontinuation of some associated medications and to a slowing down of FEV 1 decline. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Real Life Active Gaming Practices of 7-11-Year-Old Children.

    Science.gov (United States)

    Allsop, Susan; Rumbold, Penny Louise Sheena; Debuse, Dorothée; Dodd-Reynolds, Caroline

    2013-12-01

    In the laboratory, active gaming has been shown to increase physical activity levels in children compared with seated media activities. The information is sparse, however, about children's real life active gaming practices, and the laboratory protocols used thus far might not be representative. The purpose of the present study was to establish the sociodemographic characteristics, real life active gaming practices, and reasons for gameplay, to later inform intervention studies. An "Active Gaming Questionnaire" was purposely developed and distributed to 44 7-11-year-old children and their parents. Forty questionnaires were completed and returned. Analysis found 95 percent of the children had access to active gaming consoles "at home." The favorite console was the Nintendo (Kyoto, Japan) Wii™, and the favorite game was Nintendo "Wii Sports." The majority of children frequently played active games against other people. The average reported gameplay time was 81 minutes on 1-2 days per week, usually on a Saturday. More than half of the children (52.5 percent) consumed foods and/or drinks during play, which was significantly associated (P=0.000) with an extended average gameplay time (increased by 25 minutes). The majority of participants (65 percent) considered active gaming to be an alternative form of exercise, and main reasons for active videogame play included for entertainment, health benefits, and the environment. In conclusion, children 9.3±1.4 years old typically play Nintendo "Wii Sports," once or twice per week for 81 minutes. Reported active gameplay time is extended by 25 minutes when food and/or drinks are consumed.

  8. Real-life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapy.

    Science.gov (United States)

    Kiel, Menno A; Röder, Esther; Gerth van Wijk, Roy; Al, Maiwenn J; Hop, Wim C J; Rutten-van Mölken, Maureen P M H

    2013-08-01

    Subcutaneous allergen immunotherapy (SCIT) and sublingual allergen immunotherapy (SLIT) are safe and effective treatments of allergic rhinitis, but high levels of compliance and persistence are crucial to achieving the desired clinical effects. Our objective was to assess levels and predictors of compliance and persistence among grass pollen, tree pollen, and house dust mite immunotherapy users in real life and to estimate the costs of premature discontinuation. We performed a retrospective analysis of a community pharmacy database from The Netherlands containing data from 6486 patients starting immunotherapy for 1 or more of the allergens of interest between 1994 and 2009. Two thousand seven hundred ninety-six patients received SCIT, and 3690 received SLIT. Time to treatment discontinuation was analyzed and included Cox proportional hazard models with time-dependent covariates, where appropriate. Overall, only 18% of users reached the minimally required duration of treatment of 3 years (SCIT, 23%; SLIT, 7%). Median durations for SCIT and SLIT users were 1.7 and 0.6 years, respectively (P < .001). Other independent predictors of premature discontinuation were prescriber, with patients of general practitioners demonstrating longer persistence than those of allergologists and other medical specialists; single-allergen immunotherapy, lower socioeconomic status; and younger age. Of the persistent patients, 56% were never late in picking up their medication from the pharmacy. Direct medication costs per nonpersistent patient discontinuing in the third year of treatment were €3800, an amount that was largely misspent. Real-life persistence is better in SCIT users than in SLIT users, although it is low overall. There is an urgent need for further identification of potential barriers and measures that will enhance persistence and compliance. Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

  9. Test case prioritization using Cuscuta search

    Directory of Open Access Journals (Sweden)

    Mukesh Mann

    2014-12-01

    Full Text Available Most companies are under heavy time and resource constraints when it comes to testing a software system. Test prioritization technique(s allows the most useful tests to be executed first, exposing faults earlier in the testing process. Thus makes software testing more efficient and cost effective by covering maximum faults in minimum time. But test case prioritization is not an easy and straightforward process and it requires huge efforts and time. Number of approaches is available with their proclaimed advantages and limitations, but accessibility of any one of them is a subject dependent. In this paper, artificial Cuscuta search algorithm (CSA inspired by real Cuscuta parasitism is used to solve time constraint prioritization problem. We have applied CSA for prioritizing test cases in an order of maximum fault coverage with minimum test suite execution and compare its effectiveness with different prioritization ordering. Taking into account the experimental results, we conclude that (i The average percentage of faults detection (APFD is 82.5% using our proposed CSA ordering which is equal to the APFD of optimal and ant colony based ordering whereas No ordering, Random ordering and Reverse ordering has 76.25%, 75%, 68.75% of APFD respectively.

  10. A Comparison of Online Social Networks and Real-Life Social Networks: A Study of Sina Microblogging

    Directory of Open Access Journals (Sweden)

    Dayong Zhang

    2014-01-01

    Full Text Available Online social networks appear to enrich our social life, which raises the question whether they remove cognitive constraints on human communication and improve human social capabilities. In this paper, we analyze the users' following and followed relationships based on the data of Sina Microblogging and reveal several structural properties of Sina Microblogging. Compared with real-life social networks, our results confirm some similar features. However, Sina Microblogging also shows its own specialties, such as hierarchical structure and degree disassortativity, which all mark a deviation from real-life social networks. The low cost of the online network forms a broader perspective, and the one-way link relationships make it easy to spread information, but the online social network does not make too much difference in the creation of strong interpersonal relationships. Finally, we describe the mechanisms for the formation of these characteristics and discuss the implications of these structural properties for the real-life social networks.

  11. Real-life effectiveness of smoking-cessation treatments in general practice clinics in Denmark. The Escape Smoke project

    DEFF Research Database (Denmark)

    Poulsen, Peter Bo; Spillemose, Heidi; Nielsen, Gerda

    2015-01-01

    BACKGROUND: The smoking prevalence has not decreased in the last years in Denmark. General practice (GP) offers smoking cessation (SC) treatment. Studies of real-life effectiveness of daily practice SC-activities from the GP-setting opposed to efficacy results from randomized clinical trials...... are few. The study aim was to evaluate the real-life effectiveness of SC-treatments for daily smokers among Danish GP-clinics. METHODS: In a multi-centre-based observational study design Danish GP-clinics with prior SC-activity recruited daily smokers motivated for quitting. As per usual clinical practice...

  12. Automation of Test Cases for Web Applications : Automation of CRM Test Cases

    OpenAIRE

    Seyoum, Alazar

    2012-01-01

    The main theme of this project was to design a test automation framework for automating web related test cases. Automating test cases designed for testing a web interface provide a means of improving a software development process by shortening the testing phase in the software development life cycle. In this project an existing AutoTester framework and iMacros test automation tools were used. CRM Test Agent was developed to integrate AutoTester to iMacros and to enable the AutoTester,...

  13. Process mining routinely collected electronic health records to define real-life clinical pathways during chemotherapy.

    Science.gov (United States)

    Baker, Karl; Dunwoodie, Elaine; Jones, Richard G; Newsham, Alex; Johnson, Owen; Price, Christopher P; Wolstenholme, Jane; Leal, Jose; McGinley, Patrick; Twelves, Chris; Hall, Geoff

    2017-07-01

    There is growing interest in the use of routinely collected electronic health records to enhance service delivery and facilitate clinical research. It should be possible to detect and measure patterns of care and use the data to monitor improvements but there are methodological and data quality challenges. Driven by the desire to model the impact of a patient self-test blood count monitoring service in patients on chemotherapy, we aimed to (i) establish reproducible methods of process-mining electronic health records, (ii) use the outputs derived to define and quantify patient pathways during chemotherapy, and (iii) to gather robust data which is structured to be able to inform a cost-effectiveness decision model of home monitoring of neutropenic status during chemotherapy. Electronic Health Records at a UK oncology centre were included if they had (i) a diagnosis of metastatic breast cancer and received adjuvant epirubicin and cyclosphosphamide chemotherapy or (ii) colorectal cancer and received palliative oxaliplatin and infusional 5-fluorouracil chemotherapy, and (iii) were first diagnosed with cancer between January 2004 and February 2013. Software and a Markov model were developed, producing a schematic of patient pathways during chemotherapy. Significant variance from the assumed care pathway was evident from the data. Of the 535 patients with breast cancer and 420 with colorectal cancer there were 474 and 329 pathway variants respectively. Only 27 (5%) and 26 (6%) completed the planned six cycles of chemotherapy without having unplanned hospital contact. Over the six cycles, 169 (31.6%) patients with breast cancer and 190 (45.2%) patients with colorectal cancer were admitted to hospital. The pathways of patients on chemotherapy are complex. An iterative approach to addressing semantic and data quality issues enabled the effective use of routinely collected patient records to produce accurate models of the real-life experiences of chemotherapy patients and

  14. Virtual Worlds: Relationship Between Real Life and Experience in Second Life

    Directory of Open Access Journals (Sweden)

    Scott P. Anstadt

    2013-09-01

    Full Text Available Due to the unique applications of virtual reality in many modern contexts, Second Life (SL offers inimitable opportunities for research and exploration and experiential learning as part of a distance learning curriculum assignment. A review of current research regarding SL examined real world social influences in online interactions and what the effects on users may be. This aids students in understanding the social constructionist perceptions and worldview of those persons they may serve in social services. This suggests the importance of developing an understanding of the relationship between users’ real life (RL and their SL. Some research has begun to reveal the effectiveness of telecommunication and computer simulation with certain clients in the fields of mental health and social work, yet there is a lack of sufficient research done within the context of virtual worlds. The current study surveyed users of several educationally and health focused SIMS (simulations as to what motivates their SL and RL interactions. The data explores associations between users’ RL and their SL in several areas,potentially addressing the future role of educating social work students regarding research methodology in online virtual reality interactions. Implications for social work are discussed including engaging clients using incentives for social participation built into the SL milieu.

  15. Regorafenib in the Real-Life Clinical Practice: Data from the Czech Registry.

    Science.gov (United States)

    Kopeckova, Katerina; Buchler, Tomas; Bortlicek, Zbynek; Hejduk, Karel; Chloupkova, Renata; Melichar, Bohuslav; Pokorna, Petra; Tomasek, Jiri; Linke, Zdenek; Petruzelka, Lubos; Kiss, Igor; Prausova, Jana

    2017-02-01

    To describe the use of regorafenib for the treatment of metastatic colorectal cancer (mCRC) in clinical practice in the Czech Republic, and to describe the clinical outcomes of patients in terms of safety and survival. The data of patients treated with regorafenib were extracted from the national CORECT registry. The CORECT registry is a non-interventional post-marketing database, gathering information about patients with CRC and treated with targeted agents. Twenty oncology centres in the Czech Republic contributed to this registry. Collected data included patients' characteristics, disease history, cancer treatments, response to treatments and safety. A total of 148 patients treated with regorafenib in clinical practice were analysed. At regorafenib initiation, almost all patients were fully active or slightly restricted in physical activity. Regorafenib was not administered as first-line treatment in any patient. Median progression-free survival was 3.5 months and median overall survival was 9.3 months. One-year survival rate was 44.6 %. Four partial responses were observed and 51 stable diseases. Progression was observed in 66 patients (44.6 %). The main reported adverse events were skin toxicity (5.4 %) and fatigue (2.0 %). Regorafenib is a well-established treatment for pretreated patients with mCRC, however real-life data are scarce. Our results demonstrated slightly better efficacy of regorafenib and better safety profile in patients with mCRC compared to the randomised trials.

  16. A real life clinical practice of neurologists in the ambulatory setting in Thailand: a pragmatic study

    Directory of Open Access Journals (Sweden)

    Kannikar Kongbunkiat

    2015-06-01

    Full Text Available The burden of neurological disorders is high in developing countries. Real life data from neurologists as to how they practice in Thailand are limited in literature. Practices of neurologists in a university hospital clinical setting in Thailand were studied. A prospective study was performed at the ambulatory neurology clinic, Khon Kaen University Hospital, between 1 February and 31 October 2009. The following data were recorded: numbers of patients, characteristics of patients, consultation notes, and time spent for each patient. There were three neurologists, each of whom ran one afternoon clinic, once a week. There were 6137 visits during the 9 months, with an average of 681 visits per month. The total number of patients was 2834. The three most common diseases were cerebrovascular diseases (33%, epilepsy (16%, and movement disorders (non-Parkinson’s disease, 12%. Neurologists spent an average of 6.34 minutes per patient. In conclusion, neurologists in medical schools have limited time to take care of each patient. Several strategies are needed in medical education and neurology training to improve the quality of care.

  17. Real-Life/Real-Time Elderly Fall Detection with a Triaxial Accelerometer.

    Science.gov (United States)

    Sucerquia, Angela; López, José David; Vargas-Bonilla, Jesús Francisco

    2018-04-05

    The consequences of a fall on an elderly person can be reduced if the accident is attended by medical personnel within the first hour. Independent elderly people often stay alone for long periods of time, being in more risk if they suffer a fall. The literature offers several approaches for detecting falls with embedded devices or smartphones using a triaxial accelerometer. Most of these approaches have not been tested with the target population or cannot be feasibly implemented in real-life conditions. In this work, we propose a fall detection methodology based on a non-linear classification feature and a Kalman filter with a periodicity detector to reduce the false positive rate. This methodology requires a sampling rate of only 25 Hz; it does not require large computations or memory and it is robust among devices. We tested our approach with the SisFall dataset achieving 99.4% of accuracy. We then validated it with a new round of simulated activities with young adults and an elderly person. Finally, we give the devices to three elderly persons for full-day validations. They continued with their normal life and the devices behaved as expected.

  18. 'Real-life' effectiveness studies of omalizumab in adult patients with severe allergic asthma: systematic review.

    Science.gov (United States)

    Abraham, I; Alhossan, A; Lee, C S; Kutbi, H; MacDonald, K

    2016-05-01

    We reviewed 24 'real-life' effectiveness studies of omalizumab in the treatment of severe allergic asthma that included 4117 unique patients from 32 countries with significant heterogeneity in patients, clinicians and settings. The evidence underscores the short- and long-term benefit of anti-IgE therapy in terms of the following: improving lung function; achieving asthma control and reducing symptomatology, severe exacerbations and associated work/school days lost; reducing healthcare resource utilizations, in particular hospitalizations, hospital lengths of stay and accident specialist or emergency department visits; reducing or discontinuing other asthma medications; and improving quality of life - thus confirming, complementing and extending evidence from randomized trials. Thus, omalizumab therapy is associated with signal improvements across the full objective and subjective burden of illness chain of severe allergic asthma. Benefits of omalizumab may extend up to 2-4 years, and the majority of omalizumab-treated patients may benefit for many years. Omalizumab has positive short- and long-term safety profiles similar to what is known from randomized clinical trials. Initiated patients should be monitored for treatment response at 16 weeks. Those showing positive response at that time are highly likely to show sustained treatment response and benefit in terms of clinical, quality of life and health resource utilization outcomes. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  19. Hearts and Minds: Real-Life Cardiotoxicity With Clozapine in Psychosis.

    Science.gov (United States)

    Joy, George; Whiskey, Eromona; Bolstridge, Mark; Porras-Segovia, Alejandro; McDonagh, Theresa A; Plymen, Carla M; Shergill, Sukhi S

    2017-12-01

    Schizophrenia has a 1% prevalence in the population; 30% of these patients are treatment refractory. Clozapine is the only drug licensed to treat treatment refractory psychosis, but concerns about potential adverse effects result in only a proportion of eligible patients being treated. Although a well-documented neutropenia risk is mitigated by routine blood testing, cardiac toxicity is a commonly cited reason to discontinue clozapine treatment. However, there is little data on the real-life cardiac outcomes in those receiving clozapine treatment. Retrospective review of electrocardiogram, echocardiogram, and clinical outcomes in 39 inpatients with treatment-refractory schizophrenia, treated with clozapine and other antipsychotic medication, referred for cardiology opinion. Commonest reasons for referral were development of left ventricular (LV) impairment or sinus tachycardia with normal LV function. Patients were reviewed by a range of cardiologists, receiving varied interventions.Median LV ejection fraction in the clozapine group was normal (52%). Serial echocardiograms demonstrated that clozapine-treated patients with LV impairment had no change in LV ejection fraction over a 4-month follow-up. Left ventricular ejection fraction did not differ between patients treated with clozapine and other antipsychotics. However, over an 11-year follow-up period, 48% of patients had discontinued clozapine treatment. This naturalistic study demonstrates that clozapine is not associated with significant cardiac mortality or morbidity. There is a real need for multidisciplinary working between specialist cardiologists and psychiatrists caring for these complex patients to facilitate optimal long-term physical and mental health outcomes.

  20. Exploring sustainability transitions in households: insights from real-life experiments

    Science.gov (United States)

    Baedeker, Carolin; Buhl, Johannes; Greiff, Kathrin; Hasselkuß, Marco; Liedtke, Christa; Lukas, Melanie

    2016-04-01

    Societal transformation towards sustainable consumption and production, especially in urban areas, is a key challenge. The design and implementation of sustainable product service systems (PSS) might be the initial point, in which private households play a major role. The Sustainable LivingLab research infrastructure was developed as an experimental setting for investigating consumption and production patterns in private households, especially to explore socio-technical innovations which are helpful to guide sustainability transitions. The suggested presentation describes results of several real-life experiments conducted in German households, e.g. the project SusLabNRW (North-Rhine Westphalia as part of the European SusLabNWE-Project), the EnerTransRuhr project as well as the PATHWAYS project that explore patterns of action, time use, social practices and the related resource use in private households. The presentation gives an overview of the employed methods and analysed data (qualitative interviews, social network analysis, survey on household activities and inventories and a sustainability assessment (resource profiles - MIPS household analysis). Households' resource consumption was calculated in all fields of activity to analyse social practices' impact. The presentation illustrates how aggregated data can inform scenario analysis and concludes with an outlook onto transition pathways at household level and socio-technical innovations in the fields of housing, nutrition and mobility.

  1. Ultrasonic wave propagation in real-life austenitic V-butt welds: Numerical modeling and validation

    International Nuclear Information System (INIS)

    Hannemann, R.; Marklein, R.; Langenberg, K. J.; Schurig, C.; Koehler, B.; Walte, F.

    2000-01-01

    In nondestructive testing the evaluation of austenitic steel welds with ultrasound is a commonly used method. But, since the wave propagation, scattering, and diffraction effects in such complicated media are hardly understood, computer simulations are very helpful to increase the knowledge of the physical phenomena in such samples. A particularly powerful numerical time domain modeling tool is the well established Elastodynamic Finite Integration Technique (EFIT). Recently, EFIT has been extended to simulate elastic waves in inhomogeneous anisotropic media. In this paper, the step-by-step evaluation of ultrasonic wave propagation in inhomogeneous anisotropic media will be described and the results will be validated against measurements. As a simplified model, a V-butt weld with perpendicular grain structure is investigated. The coincidence between the B Scans of the simulation and the measurement of an idealized V-butt weld is remarkable and even effects predicted by theory and simulation - the appearance of two coupled quasi-SV waves - can be observed. As a next step, an improved and more realistic model of the grain orientation inside the V-butt weld is introduced. This model has been implemented in the EFIT code and has been validated against measurements. For this verification, measured and simulated B-Scans for a real-life V-butt weld have been compared and a significant coincidence has been observed. Furthermore, the main pulses in the B-Scans are interpreted by analyzing the snapshot-movies of the wavefronts

  2. Moving through time: the role of personality in three real-life contexts.

    Science.gov (United States)

    Duffy, Sarah E; Feist, Michele I; McCarthy, Steven

    2014-01-01

    In English, two deictic space-time metaphors are in common usage: the Moving Ego metaphor conceptualizes the ego as moving forward through time and the Moving Time metaphor conceptualizes time as moving forward toward the ego (Clark, 1973). Although earlier research investigating the psychological reality of these metaphors has typically examined spatial influences on temporal reasoning (e.g., Boroditsky & Ramscar, 2002), recent lines of research have extended beyond this, providing initial evidence that personality differences and emotional experiences may also influence how people reason about events in time (Duffy & Feist, 2014; Hauser, Carter, & Meier, 2009; Richmond, Wilson, & Zinken, 2012). In this article, we investigate whether these relationships have force in real life. Building on the effects of individual differences in self-reported conscientiousness and procrastination found by Duffy and Feist (2014), we examined whether, in addition to self-reported conscientiousness and procrastination, there is a relationship between conscientious and procrastinating behaviors and temporal perspective. We found that participants who adopted the Moving Time perspective were more likely to exhibit conscientious behaviors, while those who adopted the Moving Ego perspective were more likely to procrastinate, suggesting that the earlier effects reach beyond the laboratory. Copyright © 2014 Cognitive Science Society, Inc.

  3. The impact of real life treatment strategies for Candida peritonitis-A retrospective analysis.

    Science.gov (United States)

    Dubler, S; Laun, M; Koch, C; Hecker, A; Weiterer, S; Siegler, B H; Röhrig, R; Weigand, M A; Lichtenstern, C

    2017-07-01

    Candida species are commonly detected isolates from abdominal foci. The question remains as to who would benefit from early empiric treatment in cases of Candida peritonitis. This study collected real-life data on critically ill patients with Candida peritonitis to estimate the relevance of the chosen treatment strategy on the outcome of these patients. One hundred and thirty-seven surgical intensive care unit (ICU) patients with intra-abdominal invasive Candidiasis were included in the study. Fifty-six patients did not get any antifungal agent. Twenty-nine patients were empirically treated, and 52 patients were specifically treated. In the group without, with empiric and with specific antifungal treatment, the 30-day mortality rate was 33.9, 48.3 and 44.2 respectively. Candida albicans was the most frequently found species. Seven patients in the specific treatment group and one patient in the empiric treatment group emerged with candidaemia. Age, leucocyte count, APACHE II Score and acute liver failure were independent predictors of 30-day mortality in patients with Candida peritonitis. Not all patients with Candida peritonitis received antifungal treatment in real clinical practice. Patients with higher morbidity more often got antifungals. Early empirical therapy has not been associated with a better 30-day mortality. © 2017 Blackwell Verlag GmbH.

  4. Emotive hemispheric differences measured in real-life portraits using pupil diameter and subjective aesthetic preferences.

    Science.gov (United States)

    Blackburn, Kelsey; Schirillo, James

    2012-06-01

    The biased positioning of faces exposed to viewers of Western portraiture has suggested there may be fundamental differences in the lateralized expression and perception of emotion. The present study investigates whether there are differences in the perception of the left and right sides of the face in real-life photographs of individuals. The study paired conscious aesthetic ratings of pleasantness with measurements of pupil size, which are thought to be a reliable unconscious measure of interest first tested by Hess. Images of 10 men and 10 women were taken from the left and right sides of the face. These images were also mirror-reversed. As expected, we found a strong preference for left-sided portraits (regardless of original or mirror-reversed orientation), such that left hemifaces elicited higher ratings and greater pupil dilation. Interestingly, this effect was true of both sexes. A positive linear relationship was also found between pupil size and aesthetic ratings such that pupil size increased with pleasantness ratings. These findings provide support for the notions of lateralized emotion, right-hemispheric dominance, pupillary dilation to pleasant images, and constriction to unpleasant images.

  5. Issues of Application of Machine Learning Models for Virtual and Real-Life Buildings

    Directory of Open Access Journals (Sweden)

    Young Min Kim

    2016-06-01

    Full Text Available The current Building Energy Performance Simulation (BEPS tools are based on first principles. For the correct use of BEPS tools, simulationists should have an in-depth understanding of building physics, numerical methods, control logics of building systems, etc. However, it takes significant time and effort to develop a first principles-based simulation model for existing buildings—mainly due to the laborious process of data gathering, uncertain inputs, model calibration, etc. Rather than resorting to an expert’s effort, a data-driven approach (so-called “inverse” approach has received growing attention for the simulation of existing buildings. This paper reports a cross-comparison of three popular machine learning models (Artificial Neural Network (ANN, Support Vector Machine (SVM, and Gaussian Process (GP for predicting a chiller’s energy consumption in a virtual and a real-life building. The predictions based on the three models are sufficiently accurate compared to the virtual and real measurements. This paper addresses the following issues for the successful development of machine learning models: reproducibility, selection of inputs, training period, outlying data obtained from the building energy management system (BEMS, and validation of the models. From the result of this comparative study, it was found that SVM has a disadvantage in computation time compared to ANN and GP. GP is the most sensitive to a training period among the three models.

  6. Real-life decision making in college students. II: Do individual differences show reliable effects?

    Science.gov (United States)

    Galotti, Kathleen M; Tandler, Jane M; Wiener, Hillary J D

    2014-01-01

    First-year undergraduates participated in a short-term longitudinal study of real-life decision making over their first 14 months of college. They were surveyed about 7 different decisions: choosing courses for upcoming terms (on 3 different occasions), choosing an academic major (twice), planning for the upcoming summer, and planning for sophomore-year housing. They also completed a survey of self-reported decision-making styles and the Need for Cognition survey (Cacioppo & Petty, 1982) to assess their focus on rationality and enjoyment of analytic thinking. Results showed few statistically significant correlations between stylistic measures and behavioral measures of decision making, in either the amount of information considered or the way in which the information integration tracked predictions of linear models of decision making applied to each participant's data. However, there were consistent correlations, across the 7 decisions, between stylistic measures and affective reactions to, or retrospective descriptions of, episodes of decision making. We suggest that decision-making styles instruments may better reflect the construction of narratives of self as a decision maker more than they do actual behavior during decision making.

  7. The use of questionnaires in colour research in real-life settings : In search of validity and methodological pitfalls

    NARCIS (Netherlands)

    Bakker, I.C.; van der Voordt, Theo; Vink, P.; de Boon, J

    2014-01-01

    This research discusses the validity of applying questionnaires in colour research in real life settings.
    In the literature the conclusions concerning the influences of colours on human performance and well-being are often conflicting. This can be caused by the artificial setting of the test

  8. Menu-engineering in restaurants - adapting portion sizes on plates to enhance vegetable consumption: a real-life experiment.

    NARCIS (Netherlands)

    Reinders, M.J.; Huitink, M.; Dijkstra, S.C.; Maaskant, A.J.; Heijnen, J.

    2017-01-01

    Background: The aim of this research was to investigate whether increased portion sizes of vegetables and decreased portion sizes of meat on main dishes increased the amount of vegetables consumed in a real-life restaurant setting without affecting customer satisfaction. The participants were

  9. Mapping real-life applications on run-time reconfigurable NoC-based MPSoC on FPGA.

    NARCIS (Netherlands)

    Singh, A.K.; Kumar, A.; Srikanthan, Th.; Ha, Y.

    2010-01-01

    Multiprocessor systems-on-chip (MPSoC) are required to fulfill the performance demand of modern real-life embedded applications. These MPSoCs are employing Network-on-Chip (NoC) for reasons of efficiency and scalability. Additionally, these systems need to support run-time reconfiguration of their

  10. Exploring Marine Ecosystems with Elementary School Portuguese Children: Inquiry-Based Project Activities Focused on "Real-Life" Contexts

    Science.gov (United States)

    Guilherme, Elsa; Faria, Cláudia; Boaventura, Diana

    2016-01-01

    The purpose of the study was to investigate how young students engage in an inquiry-based project driven by real-life contexts. Elementary school children were engaged in a small inquiry project centred on marine biodiversity and species adaptations. All activities included the exploration of an out-of-school setting as a learning context. A total…

  11. The fragrance hand immersion study - an experimental model simulating real-life exposure for allergic contact dermatitis on the hands

    DEFF Research Database (Denmark)

    Heydorn, S; Menné, T; Andersen, K E

    2003-01-01

    .p.m.), whilst during the following 2 weeks, the concentration was relatively high (approximately 250 p.p.m.), imitating real-life exposure to a household product like dishwashing liquid diluted in water and the undiluted product, respectively. Evaluation was made using a clinical scale and laser Doppler flow...

  12. Blue Tigers, Black Tapirs, & the Pied Raven of the Faroe Islands: Teaching Genetic Drift Using Real-Life Animal Examples

    Science.gov (United States)

    Robischon, Marcel

    2015-01-01

    Genetic drift is a concept of population genetics that is central to understanding evolutionary processes and aspects of conservation biology. It is frequently taught using rather abstract representations. I introduce three real-life zoological examples, based on historical and recent color morphs of tigers, tapirs, and ravens, that can complement…

  13. EDITORIAL Wireless sensor networks: design for real-life deployment and deployment experiences Wireless sensor networks: design for real-life deployment and deployment experiences

    Science.gov (United States)

    Gaura, Elena; Roedig, Utz; Brusey, James

    2010-12-01

    modalities and (iv) system solutions with high end-user added value and cost benefits. The common thread is deployment and deployment evaluation. In particular, satisfaction of application requirements, involvement of the end-user in the design and deployment process, satisfactory system performance and user acceptance are concerns addressed in many of the contributions. The contributions form a valuable set, which help to identify the priorities for research in this burgeoning area: Robust, reliable and efficient data collection in embedded wireless multi-hop networks are essential elements in creating a true deploy-and-forget user experience. Maintaining full connectivity within a WSN, in a real world environment populated by other WSNs, WiFi networks or Bluetooth devices that constitute sources of interference is a key element in any application, but more so for those that are safety-critical, such as disaster response. Awareness of the effects of wireless channel, physical position and line-of-sight on received signal strength in real-world, outdoor environments will shape the design of many outdoor applications. Thus, the quantification of such effects is valuable knowledge for designers. Sensors' failure detection, scalability and commercialization are common challenges in many long-term monitoring applications; transferable solutions are evidenced here in the context of pollutant detection and water quality. Innovative, alternative thinking is often needed to achieve the desired long-lived networks when power-hungry sensors are foreseen components; in some instances, the very problems of wireless technology, such as RF irregularity, can be transformed into advantages. The importance of an iterative design and evaluation methodology—from analysis to simulation to real-life deployment—should be well understood by all WSN developers. The value of this is highlighted in the context of a challenging WPAN video-surveillance application based on a novel Nomadic Access

  14. Adapting the SLIM diabetes prevention intervention to a Dutch real-life setting: joint decision making by science and practice.

    Science.gov (United States)

    Jansen, Sophia C; Haveman-Nies, Annemien; Duijzer, Geerke; Ter Beek, Josien; Hiddink, Gerrit J; Feskens, Edith J M

    2013-05-08

    Although many evidence-based diabetes prevention interventions exist, they are not easily applicable in real-life settings. Moreover, there is a lack of examples which describe the adaptation process of these interventions to practice. In this paper we present an example of such an adaptation. We adapted the SLIM (Study on Lifestyle intervention and Impaired glucose tolerance Maastricht) diabetes prevention intervention to a Dutch real-life setting, in a joint decision making process of intervention developers and local health care professionals. We used 3 adaptation steps in accordance with current adaptation frameworks. In the first step, the elements of the SLIM intervention were identified. In the second step, these elements were judged for their applicability in a real-life setting. In the third step, adaptations were proposed and discussed for those elements which were deemed not applicable. Participants invited for this process included intervention developers and local health care professionals (n=19). In the first adaptation step, a total of 22 intervention elements were identified. In the second step, 12 of these 22 intervention elements were judged as inapplicable. In the third step, a consensus was achieved for the adaptations of all 12 elements. The adapted elements were in the following categories: target population, techniques, intensity, delivery mode, materials, organisational structure, and political and financial conditions. The adaptations either lay in changing the SLIM protocol (6 elements) or the real-life working procedures (1 element), or a combination of both (4 elements). The positive result of this study is that a consensus was achieved within a relatively short time period (nine months) between the developers of the SLIM intervention and local health care professionals on the adaptations needed to make SLIM applicable in a Dutch real-life setting. Our example shows that it is possible to combine the perspectives of scientists and

  15. Motivational valence alters memory formation without altering exploration of a real-life spatial environment.

    Science.gov (United States)

    Chiew, Kimberly S; Hashemi, Jordan; Gans, Lee K; Lerebours, Laura; Clement, Nathaniel J; Vu, Mai-Anh T; Sapiro, Guillermo; Heller, Nicole E; Adcock, R Alison

    2018-01-01

    motivated learning implies that dissociable behavioral and biological mechanisms, here varying as a function of valence, contribute to memory outcomes in complex, real-life environments.

  16. Motivational valence alters memory formation without altering exploration of a real-life spatial environment.

    Directory of Open Access Journals (Sweden)

    Kimberly S Chiew

    characterization of motivated learning implies that dissociable behavioral and biological mechanisms, here varying as a function of valence, contribute to memory outcomes in complex, real-life environments.

  17. Immunosuppressive Drug Discontinuation in Noninfectious Uveitis From Real-Life Clinical Practice: A Survival Analysis.

    Science.gov (United States)

    Abásolo, Lydia; Rosales, Zulema; Díaz-Valle, David; Gómez-Gómez, Alejandro; Peña-Blanco, Rayma C; Prieto-García, Ángela; Benítez-Del-Castillo, José Manuel; Pato, Esperanza; García-Feijoo, Julián; Fernández-Gutiérrez, Benjamín; Rodriguez-Rodriguez, Luis

    2016-09-01

    To assess in uveitis patients the rate of immunosuppressive drug (ISD) discontinuation in real-life clinical practice, comparing this rate among ISDs. Longitudinal retrospective cohort study. We included uveitis patients attending a tertiary eye referral center from Madrid (Spain) between 1989 and 2015, prescribed any ISDs (cyclosporine, methotrexate, azathioprine, anti-TNF drugs, or others). Our main outcome was discontinuation of all ISDs owing to clinical efficacy, inefficacy, adverse drug reaction (ADR), and other medical causes. Discontinuation rates (DRs) per 100 patient-years were estimated. Variables associated with specific-cause discontinuations were analyzed using Cox bivariate and multivariate models. We analyzed 110 patients with 263 treatment courses and 665.2 patient-years of observation. Cyclosporine (66.4%), methotrexate (47.3%), azathioprine (30.9%), and anti-TNFs (30.9%) were the most frequently used ISDs. Treatment was suspended in 136 cases (mostly owing to clinical efficacy [38.2%], inefficacy [26.5%], and ADRs [22.8%]). All-cause DR with 95% confidence interval was 20.4 [17.3-24.2]. Retention rates at 1 and 10 years were 74% and 16%, respectively. In the multivariate analysis, combined treatment exhibited higher DRs owing to clinical efficacy than other ISDs in monotherapy. Conversely, nonbiologic combination therapy with azathioprine exhibited the highest DR owing to ADRs. Clinical efficacy was the most frequent cause for ISD discontinuation, followed by inefficacy and ADRs. DR owing to efficacy was higher for combination therapy. Furthermore, nonbiologic combination therapy with azathioprine was associated with a higher DR owing to ADRs. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Me, us, and them: Testing sociometer theory in a socially diverse real-life context.

    Science.gov (United States)

    Reitz, Anne K; Motti-Stefanidi, Frosso; Asendorpf, Jens B

    2016-06-01

    Although numerous studies have emphasized the role evaluations by others play for people's self-esteem, the perspective of others and the social diversity of real-life contexts have largely been ignored. In a large-scale longitudinal study, we examined the link between adolescents' self-esteem and their self- and peer-perceived popularity in socially diverse classrooms. First, we tested the competing directions of effects predicted by sociometer theory (i.e., peer-perceived popularity affects self-esteem, mediated by self-perceived popularity) and the self-broadcasting perspective (i.e., self-esteem affects peer-perceived popularity). Second, we examined differential effects of popularity in the own social group ("us") versus others ("them") by using immigrant status groups (i.e., immigrants versus host-nationals). We examined 1,057 13-year-old students in 3 annual waves. Cross-lagged analyses revealed that popularity among peers of the in-group but not among peers of the out-group prospectively predicted self-esteem, which was mediated by self-perceived popularity. Self-esteem in turn prospectively predicted self- but not peer-perceived popularity. In sum, the findings provide support for sociometer theory and a conscious sociometer mechanism but no support for the self-broadcasting perspective. The findings further demonstrate that the sociometer was more responsive to popularity in immigrant status in- than out-groups. In conclusion, the findings underscore the need to consider the perspective of others and their social group memberships to better understand the complexities of the link between self-esteem and popularity. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  19. Motivational valence alters memory formation without altering exploration of a real-life spatial environment

    Science.gov (United States)

    Hashemi, Jordan; Gans, Lee K.; Lerebours, Laura; Clement, Nathaniel J.; Vu, Mai-Anh T.; Sapiro, Guillermo; Heller, Nicole E.; Adcock, R. Alison

    2018-01-01

    motivated learning implies that dissociable behavioral and biological mechanisms, here varying as a function of valence, contribute to memory outcomes in complex, real-life environments. PMID:29558526

  20. Effects of omalizumab in severe asthmatics across ages: A real life Italian experience.

    Science.gov (United States)

    Sposato, B; Scalese, M; Latorre, M; Scichilone, N; Matucci, A; Milanese, M; Masieri, S; Rolla, G; Steinhilber, G; Rosati, Y; Vultaggio, A; Folletti, I; Baglioni, S; Bargagli, E; Di Tomassi, M; Pio, R; Pio, A; Maccari, U; Maggiorelli, C; Migliorini, M G; Vignale, L; Pulerà, N; Carpagnano, G E; Foschino Barbaro, M P; Perrella, A; Paggiaro, P L

    2016-10-01

    This retrospective study aimed at evaluating long-term effects of Omalizumab in elderly asthmatics in a real-life setting. 105 consecutive severe asthmatics (GINA step 4-5; mean FEV 1 % predicted:66 ± 15.7) treated with Omalizumab for at least 1 year (treatment mean duration 35.1 ± 21.7 months) were divided into 3 groups according to their age at Omalizumab treatment onset: 18-39, 40-64 and ≥ 65 years. Comorbidities, number of overweight/obese subjects and patients with late-onset asthma were more frequent among older people. A similar reduction of inhaled corticosteroids dosage and SABA on-demand therapy was observed in all groups during Omalizumab treatment; a similar FEV 1 increased was also observed. Asthma Control Test (ACT) improved significantly (p Omalizumab but the percentage of exacerbation-free patients was higher in younger people (76.9%) compared to middle aged patients (49.2%) and the elderly (29%) (p = 0.049). After Omalizumab treatment, the risk for exacerbations was lower in subjects aged 40-64 (OR = 0.284 [CI95% = 0.098-0.826], p = 0.021) and 18-39 (OR = 0.133 [CI95% = 0.026-0.678], p = 0.015), compared to elderly asthmatics. Also, a significantly reduced ACT improvement (β = -1.070; p = 0.046) passing from each age class was observed. Omalizumab improves all asthma outcomes independently of age, although the magnitude of the effects observed in the elderly seems to be lower than in the other age groups. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Get the most from your data: a propensity score model comparison on real-life data

    Directory of Open Access Journals (Sweden)

    Ferdin

    2016-05-01

    Full Text Available Dennis Ferdinand,1 Mirko Otto,2 Christel Weiss1 1Department of Biomathematics and Medical Statistics, 2Department of Surgery, University Medical Center Mannheim (UMM, University of Heidelberg, Mannheim, Germany Purpose: In the past, the propensity score has been in the middle of several discussions in terms of its abilities and limitations. With a comprehensive review and a practical example, this study examines the effect of propensity score analysis of real-life data and introduces a simple and effective clinical approach. Materials and methods: After the authors reviewed current publications, they applied their insights to the data of a nonrandomized clinical trial in bariatric surgery. This study examined weight loss in 173 patients where 127 patients received Roux-en-Y gastric bypass surgery and 46 patients sleeve gastrectomy. Both groups underwent analysis in terms of their covariate distribution using Mann–Whitney U and χ2 testing. Mean differences within excess weight loss in native data were examined with Student’s t-test. Three propensity score models were defined and matching was performed. Covariate distribution and mean differences in excess weight loss were checked with Mann–Whitney U and χ2 testing. Results: Native data implied a significant difference in excess weight loss. The propensity score models did not confirm this difference. All models proved that both surgical procedures were equal, due to their weight-loss induction. Covariate distribution improved after the matching procedure in terms of an equal distribution. Conclusion: It seemed that a practical clinical approach with outcome-related covariates as a propensity score base is the ideal midpoint between an equal distribution in covariates and an acceptable loss of data. Nevertheless, propensity score models designed with clinical intent seemed to be absolutely suitable for overcoming heterogeneity in covariate distribution. Keywords: nonrandomized clinical

  2. Get the most from your data: a propensity score model comparison on real-life data.

    Science.gov (United States)

    Ferdinand, Dennis; Otto, Mirko; Weiss, Christel

    2016-01-01

    In the past, the propensity score has been in the middle of several discussions in terms of its abilities and limitations. With a comprehensive review and a practical example, this study examines the effect of propensity score analysis of real-life data and introduces a simple and effective clinical approach. After the authors reviewed current publications, they applied their insights to the data of a nonrandomized clinical trial in bariatric surgery. This study examined weight loss in 173 patients where 127 patients received Roux-en-Y gastric bypass surgery and 46 patients sleeve gastrectomy. Both groups underwent analysis in terms of their covariate distribution using Mann-Whitney U and χ (2) testing. Mean differences within excess weight loss in native data were examined with Student's t-test. Three propensity score models were defined and matching was performed. Covariate distribution and mean differences in excess weight loss were checked with Mann-Whitney U and χ (2) testing. Native data implied a significant difference in excess weight loss. The propensity score models did not confirm this difference. All models proved that both surgical procedures were equal, due to their weight-loss induction. Covariate distribution improved after the matching procedure in terms of an equal distribution. It seemed that a practical clinical approach with outcome-related covariates as a propensity score base is the ideal midpoint between an equal distribution in covariates and an acceptable loss of data. Nevertheless, propensity score models designed with clinical intent seemed to be absolutely suitable for overcoming heterogeneity in covariate distribution.

  3. Local contextual processing of abstract and meaningful real-life images in professional athletes.

    Science.gov (United States)

    Fogelson, Noa; Fernandez-Del-Olmo, Miguel; Acero, Rafael Martín

    2012-05-01

    We investigated the effect of abstract versus real-life meaningful images from sports on local contextual processing in two groups of professional athletes. Local context was defined as the occurrence of a short predictive series of stimuli occurring before delivery of a target event. EEG was recorded in 10 professional basketball players and 9 professional athletes of individual sports during three sessions. In each session, a different set of visual stimuli were presented: triangles facing left, up, right, or down; four images of a basketball player throwing a ball; four images of a baseball player pitching a baseball. Stimuli consisted of 15 % targets and 85 % of equal numbers of three types of standards. Recording blocks consisted of targets preceded by randomized sequences of standards and by sequences including a predictive sequence signaling the occurrence of a subsequent target event. Subjects pressed a button in response to targets. In all three sessions, reaction times and peak P3b latencies were shorter for predicted targets compared with random targets, the last most informative stimulus of the predictive sequence induced a robust P3b, and N2 amplitude was larger for random targets compared with predicted targets. P3b and N2 peak amplitudes were larger in the professional basketball group in comparison with professional athletes of individual sports, across the three sessions. The findings of this study suggest that local contextual information is processed similarly for abstract and for meaningful images and that professional basketball players seem to allocate more attentional resources in the processing of these visual stimuli.

  4. Dietary supplementation contributes to lifestyle improvement in hypercholesterolemic patients in real-life contexts.

    Science.gov (United States)

    Bruckert, E; Masana, L; Chapman, M J; Descamps, O; Bosi, E; Allaert, F A

    2014-07-01

    Assess the evolution of cardiovascular lifestyle behaviors in hypercholesterolemic patients concomitantly with changes in their daily intake of phytosterol-supplemented yoghurt (Phyto-SY). Nationwide prospective observational study conducted in general practices across France and Spain. Each practitioner suggested lifestyle changes to five consecutive patients with hypercholesterolemia (whether or not they were taking hypocholesterolemic drugs) and recommended daily consumption of Phyto-SY. The study design involved an inclusion visit, a patient's self-monitoring assessment after 1 month, and a final visit after 4 months. Primary evaluation criterion: changes in dietary habits assessed by a standardized Nutritional Lifestyle score. Secondary criteria: changes in lipid profile, anthropometry (waist circumference) and lifestyle behavior. A total of 2376 hypercholesterolemic patients (of whom 54.8% were women) were included. The average age was 56.2 years old. The Nutritional Lifestyle score improved from 15.4 ± 5.4 to 8.7 ± 4.0 (p 30 min) increased from 59.3% to 78.3% (p < 0.0001). The overweight rate decreased from 22.8% to 17.5% (p < 0.0001) and waist circumference from 94.6 ± 13.3 cm to 93.0 ± 12.8 cm (p < 0.0001). Nutritional Lifestyles and other lifestyle markers' improvement were parallel to adherence to Phyto-SY adherence. Improvements in Nutritional Lifestyle scores, which included regular consumption of Phyto-SY over 4 months, was significantly linked to healthier lifestyles and to beneficial modifications in atherogenic lipid profiles, which reflected patient empowerment in a 'real life' context.

  5. Embracing the role of real life studies in the management of rare cancers

    Directory of Open Access Journals (Sweden)

    Omar Abdel-Rahman

    2016-10-01

    Full Text Available For commonly occurring cancers, as well as situations or conditions that are frequently encountered in oncological setting, plenty of prospective data are available to oncologists or medical practitioners to facilitate the decision making process. However, for rare cancers and atypical scenarios, there are limited references in the current literature. Understandably, this is attributed to the difficulty in recruiting enough patients to systematically study such rare manifestations. Under these circumstances, the importance of real life data that are collected via population-based studies, case series, and case reports is especially significant. In the current issue of AMOR, the journal features three case reports that describe distinctly uncommon oncological scenarios. In one report, Vafaii and Shao highlighted the stepwise development of classical Hodgkin lymphoma (cHL from diffuse large B cell lymphoma (DLBCL via precursor Reed-Sternberg/Hodgkin cells, as confirmed via multiple biopsies. They suggested that cHL and DLBCL can be clonally related, even when developing metachronously in the same patient, based on the presence of a hybrid intermediate stage. Meanwhile, Xian and colleagues reported the surgical management of brachial plexus pain that is caused by Pancoast tumor. According to them, the condition closely resembles the symptoms of brachial plexus injury and thus, the underlying cause is easily misdiagnosed. Finally, Coehlo and co-workers presented a report on the prolonged disease control of esthesioneuroblastoma using a multimodality approach, combining surgery, radiotherapy, and chemotherapy to derive an effective treatment strategy. It is noteworthy that despite an initial distant metastasis setback, the patient responded positively to palliative chemotherapy, thus proving the value of the much debated approach.In short, these case reports are an invaluable addition to existing medical literature concerning the diagnoses and

  6. Is fear in your head? A comparison of instructed and real-life expressions of emotion in the face and body.

    Science.gov (United States)

    Abramson, Lior; Marom, Inbal; Petranker, Rotem; Aviezer, Hillel

    2017-04-01

    The majority of emotion perception studies utilize instructed and stereotypical expressions of faces or bodies. While such stimuli are highly standardized and well-recognized, their resemblance to real-life expressions of emotion remains unknown. Here we examined facial and body expressions of fear and anger during real-life situations and compared their recognition to that of instructed expressions of the same emotions. In order to examine the source of the affective signal, expressions of emotion were presented as faces alone, bodies alone, and naturally, as faces with bodies. The results demonstrated striking deviations between recognition of instructed and real-life stimuli, which differed as a function of the emotion expressed. In real-life fearful expressions of emotion, bodies were far better recognized than faces, a pattern not found with instructed expressions of emotion. Anger reactions were better recognized from the body than from the face in both real-life and instructed stimuli. However, the real-life stimuli were overall better recognized than their instructed counterparts. These results indicate that differences between instructed and real-life expressions of emotion are prevalent and raise caution against an overreliance of researchers on instructed affective stimuli. The findings also demonstrate that in real life, facial expression perception may rely heavily on information from the contextualizing body. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  7. Long-term Course of Alzheimer Disease in Patients Treated According to the Dutch Dementia Guideline at a Memory Clinic A "Real-Life" Study

    NARCIS (Netherlands)

    Droogsma, Erika; van Asselt, Dieneke; van Steijn, Jolanda; Diekhuis, Marjolein; Veeger, Nic; De Deyn, Peter P.

    2016-01-01

    Introduction:There is little knowledge of the long-term course of Alzheimer disease (AD) in light of current pharmacological and nonpharmacological interventions provided in a real-life setting.Methods:The Frisian Alzheimer's Disease Cohort study is a real-life study of the course of AD in patients

  8. Can virtual reality exposure therapy gains be generalized to real-life? : A meta-analysis of studies applying behavioral assessments

    NARCIS (Netherlands)

    Morina, Nexhmedin; Ijntema, Hiske; Meyerbröker, Katharina; Emmelkamp, Paul M G

    2015-01-01

    In virtual reality exposure therapy (VRET), patients are exposed to virtual environments that resemble feared real-life situations. The aim of the current study was to assess the extent to which VRET gains can be observed in real-life situations. We conducted a meta-analysis of clinical trials

  9. Absent yet Present: On the Paradoxical Nature of Characters in Nabokov’s The Real Life of Sebastian Knight

    Directory of Open Access Journals (Sweden)

    Irina Marchesini

    2016-11-01

    Full Text Available The present research is focused on the theme of absence, an area of inquiry that might seem dominant in the field of Nabokov Studies. The analysis, which concentrates in particular on the key figures of the novel The Real Life of Sebastian Knight (1941, notably the narrator V. and the poet Sebastian Knight, interprets the characters’ construction through the paradigm of absence. Arguably, the construction of characters in The Real Life of Sebastian Knight is paradoxical: absence constitutes their essence at a core level, as it often happens in the context of the self-conscious genre. Moreover, absence plays a key role in characters’ design, linking them to all Nabokovian novels. However, despite their innermost ‘flatness’, to use Edward M. Forster’s terminology, they still appear to be ‘round’, i.e. plausible, mimetic figures.

  10. Real-life efficacy and safety of omalizumab in Portuguese patients with persistent uncontrolled asthma.

    Science.gov (United States)

    Pereira Barbosa, M; Bugalho de Almeida, A; Pereira, C; Chen, C-W; Georgiou, P; Peachey, G

    2015-01-01

    The real life effectiveness, safety and the use of omalizumab for Portuguese patients with uncontrolled persistent allergic asthma are not sufficiently well known. The objective of this report was to make an evaluation, in a post-marketing, non-interventional, observational registry, of the Portuguese population included in the eXpeRience study. The methods used in this report are the same as the global eXpeRience ones, applied to a Portuguese sub-population. Patients with uncontrolled allergic asthma who had started omalizumab within the previous 15 weeks were enrolled and received omalizumab add-on therapy for 24 months. The physicians' global evaluation of treatment effectiveness (GETE), asthma symptoms and control (ACT score), quality of life (mini-AQLQ score), exacerbations, and serious adverse events (SAE) were reported. Of the 943 patients recruited in the eXpeRience registry, 62 patients were from Portugal. 62.1% of them were observed to be responders with good/excellent GETE assessment at Week 16. Clinically meaningful improvements in asthma control (ACT score) and quality of life (mini-AQLQ score) were observed with omalizumab therapy at Months 12 (mean change: +7.7 [n=35]; +2.1 [n=20], respectively) and 24 (mean change: +7.0 [n=26]; +2.7 [n=13], respectively). Asthma symptoms and rescue medication usage were reduced to ≤1 day/week at Month 24 from a baseline of ≥3.5 days/week. The proportion of patients with no clinically significant exacerbations increased from 6.5% during pre-treatment (n=62) to 50% at Month 12 (n=54) and 60% at Month 24 (n=45). The findings from the Portugal subpopulation of eXpeRience registry confirm that omalizumab add-on therapy is efficacious and well tolerated in the management of uncontrolled persistent allergic asthma. Another pertinent issue is the fact that the Portuguese subpopulation response is similar to the international population average of the study. Copyright © 2014 Sociedade Portuguesa de Pneumologia

  11. Impact of motor fluctuations on real-life gait in Parkinson's patients.

    Science.gov (United States)

    Silva de Lima, Ana Lígia; Evers, Luc J W; Hahn, Tim; de Vries, Nienke M; Daeschler, Margaret; Boroojerdi, Babak; Terricabras, Dolors; Little, Max A; Bloem, Bastiaan R; Faber, Marjan J

    2018-05-01

    People with PD (PWP) have an increased risk of becoming inactive. Wearable sensors can provide insights into daily physical activity and walking patterns. (1) Is the severity of motor fluctuations associated with sensor-derived average daily walking quantity? (2) Is the severity of motor fluctuations associated with the amount of change in sensor-derived walking quantity after levodopa intake? 304 Dutch PWP from the Parkinson@Home study were included. At baseline, all participants received a clinical examination. During the follow-up period (median: 97 days; 25-Interquartile range-IQR: 91 days, 75-IQR: 188 days), participants used the Fox Wearable Companion app and streamed smartwatch accelerometer data to a cloud platform. The first research question was assessed by linear regression on the sensor-derived mean time spent walking/day with the severity of fluctuations (MDS-UPDRS item 4.4) as independent variable, controlled for age and MDS-UPDRS part-III score. The second research question was assessed by linear regression on the sensor-derived mean post-levodopa walking quantity, with the sensor-derived mean pre-levodopa walking quantity and severity of fluctuations as independent variables, controlled for mean time spent walking per day, age and MDS-UPDRS part-III score. PWP spent most time walking between 8am and 1pm, summing up to 72 ± 39 (mean ± standard deviation) minutes of walking/day. The severity of motor fluctuations did not influence the mean time spent walking (B = 2.4 ± 1.9, p = 0.20), but higher age (B = -1.3 ± 0.3, p = motor symptoms (B = -0.6 ± 0.2, p motor fluctuations is not associated with changes in real-life walking patterns in mildly to moderate affected PWP. Copyright © 2018 Elsevier B.V. All rights reserved.

  12. A New Cuffless Device for Measuring Blood Pressure: A Real-Life Validation Study.

    Science.gov (United States)

    Schoot, Tessa S; Weenk, Mariska; van de Belt, Tom H; Engelen, Lucien J L P G; van Goor, Harry; Bredie, Sebastian J H

    2016-05-05

    Cuffless blood pressure (BP) monitoring devices, based on pulse transit time, are being developed as an easy-to-use, more convenient, fast, and relatively cheap alternative to conventional BP measuring devices based on cuff occlusion. Thereby they may provide a great alternative to BP self-measurement. The objective of our study was to evaluate the performance of the first release of the Checkme Health Monitor (Viatom Technology), a cuffless BP monitor, in a real-life setting. Furthermore, we wanted to investigate whether the posture of the volunteer and the position of the device relative to the heart level would influence its outcomes. Study volunteers fell into 3 BP ranges: high (>160 mmHg), normal (130-160 mmHg), and low (measurements were met according to the European Society of Hypertension International Protocol (ESH-IP) for the validation of BP measurement devices. After calibrating the Checkme device, we measured systolic BP with Checkme and a validated, oscillometric reference BP monitor (RM). Measurements were performed in randomized order both in supine and in sitting position, and with Checkme at and above heart level. We recruited 52 volunteers, of whom we excluded 15 (12 due to calibration failure with Checkme, 3 due to a variety of reasons). The remaining 37 volunteers were divided into low (n=14), medium (n=13), and high (n=10) BP ranges. There were 18 men and 19 women, with a mean age of 54.1 (SD 14.5) years, and mean recruitment systolic BP of 141.7 (SD 24.7) mmHg. BP results obtained by RM and Checkme correlated well. In the supine position, the difference between the RM and Checkme was >5 mmHg in 17 of 37 volunteers (46%), of whom 9 of 37 (24%) had a difference >10 mmHg and 5 of 37 (14%) had a difference >15 mmHg. BP obtained with Checkme correlated well with RM BP, particularly in the position (supine) in which the device was calibrated. These preliminary results are promising for conducting further research on cuffless BP measurement in the

  13. Measurement of Walking Ground Reactions in Real-Life Environments: A Systematic Review of Techniques and Technologies.

    Science.gov (United States)

    Shahabpoor, Erfan; Pavic, Aleksandar

    2017-09-12

    Monitoring natural human gait in real-life environments is essential in many applications, including quantification of disease progression, monitoring the effects of treatment, and monitoring alteration of performance biomarkers in professional sports. Nevertheless, developing reliable and practical techniques and technologies necessary for continuous real-life monitoring of gait is still an open challenge. A systematic review of English-language articles from scientific databases including Scopus, ScienceDirect, Pubmed, IEEE Xplore, EBSCO and MEDLINE were carried out to analyse the 'accuracy' and 'practicality' of the current techniques and technologies for quantitative measurement of the tri-axial walking ground reactions outside the laboratory environment, and to highlight their strengths and shortcomings. In total, 679 relevant abstracts were identified, 54 full-text papers were included in the paper and the quantitative results of 17 papers were used for meta-analysis and comparison. Three classes of methods were reviewed: (1) methods based on measured kinematic data; (2) methods based on measured plantar pressure; and (3) methods based on direct measurement of ground reactions. It was found that all three classes of methods have competitive accuracy levels with methods based on direct measurement of the ground reactions showing highest accuracy while being least practical for long-term real-life measurement. On the other hand, methods that estimate ground reactions using measured body kinematics show highest practicality of the three classes of methods reviewed. Among the most prominent technical and technological challenges are: (1) reducing the size and price of tri-axial load-cells; (2) improving the accuracy of orientation measurement using IMUs; (3) minimizing the number and optimizing the location of required IMUs for kinematic measurement; (4) increasing the durability of pressure insole sensors, and (5) enhancing the robustness and versatility of the

  14. Measurement of Walking Ground Reactions in Real-Life Environments: A Systematic Review of Techniques and Technologies

    Directory of Open Access Journals (Sweden)

    Erfan Shahabpoor

    2017-09-01

    Full Text Available Monitoring natural human gait in real-life environments is essential in many applications, including quantification of disease progression, monitoring the effects of treatment, and monitoring alteration of performance biomarkers in professional sports. Nevertheless, developing reliable and practical techniques and technologies necessary for continuous real-life monitoring of gait is still an open challenge. A systematic review of English-language articles from scientific databases including Scopus, ScienceDirect, Pubmed, IEEE Xplore, EBSCO and MEDLINE were carried out to analyse the ‘accuracy’ and ‘practicality’ of the current techniques and technologies for quantitative measurement of the tri-axial walking ground reactions outside the laboratory environment, and to highlight their strengths and shortcomings. In total, 679 relevant abstracts were identified, 54 full-text papers were included in the paper and the quantitative results of 17 papers were used for meta-analysis and comparison. Three classes of methods were reviewed: (1 methods based on measured kinematic data; (2 methods based on measured plantar pressure; and (3 methods based on direct measurement of ground reactions. It was found that all three classes of methods have competitive accuracy levels with methods based on direct measurement of the ground reactions showing highest accuracy while being least practical for long-term real-life measurement. On the other hand, methods that estimate ground reactions using measured body kinematics show highest practicality of the three classes of methods reviewed. Among the most prominent technical and technological challenges are: (1 reducing the size and price of tri-axial load-cells; (2 improving the accuracy of orientation measurement using IMUs; (3 minimizing the number and optimizing the location of required IMUs for kinematic measurement; (4 increasing the durability of pressure insole sensors, and (5 enhancing the robustness and

  15. The Other Side of the Screen - Simultaneously maintaining social relationships in real life and on social media

    OpenAIRE

    Gruenke, Solveig Wiland

    2017-01-01

    Social media as a social concept is becoming a prominent fixture in social life and is taking on a significant increase in social relevance, both academically and in popular discourse. The academic research is often focused on either the online content itself or the macro societal implications, more than the real-life social aspect of social media. People using social media are now simultaneously producing content about their life online, whilst they are, in fact, living it. The new social fe...

  16. Nonlinear Heart Rate Variability features for real-life stress detection. Case study: students under stress due to university examination.

    Science.gov (United States)

    Melillo, Paolo; Bracale, Marcello; Pecchia, Leandro

    2011-11-07

    This study investigates the variations of Heart Rate Variability (HRV) due to a real-life stressor and proposes a classifier based on nonlinear features of HRV for automatic stress detection. 42 students volunteered to participate to the study about HRV and stress. For each student, two recordings were performed: one during an on-going university examination, assumed as a real-life stressor, and one after holidays. Nonlinear analysis of HRV was performed by using Poincaré Plot, Approximate Entropy, Correlation dimension, Detrended Fluctuation Analysis, Recurrence Plot. For statistical comparison, we adopted the Wilcoxon Signed Rank test and for development of a classifier we adopted the Linear Discriminant Analysis (LDA). Almost all HRV features measuring heart rate complexity were significantly decreased in the stress session. LDA generated a simple classifier based on the two Poincaré Plot parameters and Approximate Entropy, which enables stress detection with a total classification accuracy, a sensitivity and a specificity rate of 90%, 86%, and 95% respectively. The results of the current study suggest that nonlinear HRV analysis using short term ECG recording could be effective in automatically detecting real-life stress condition, such as a university examination.

  17. Drop-out rate among patients treated with omalizumab for severe asthma: Literature review and real-life experience.

    Science.gov (United States)

    Caminati, M; Senna, G; Stefanizzi, G; Bellamoli, R; Longhi, S; Chieco-Bianchi, F; Guarnieri, G; Tognella, S; Olivieri, M; Micheletto, C; Festi, G; Bertocco, E; Mazza, M; Rossi, A; Vianello, A

    2016-08-25

    In patients with asthma, particularly severe asthma, poor adherence to inhaled drugs negatively affects the achievement of disease control. A better adherence rate is expected in the case of injected drugs, such as omalizumab, as they are administered only in a hospital setting. However, adherence to omalizumab has never been systematically investigated. The aim of this study was to review the omalizumab drop-out rate in randomized controlled trials (RCTs) and real-life studies. A comparative analysis was performed between published data and the Italian North East Omalizumab Network (NEONet) database. In RCTs the drop-out rate ranged from 7.1 to 19.4 %. Although the reasons for withdrawal were only occasionally reported, patient decision and adverse events were the most frequently reported causes. In real-life studies the drop-out rate ranged from 0 to 45.5 %. In most cases lack of efficacy was responsible for treatment discontinuation. According to NEONet data, 32 % of treated patients dropped out, with an increasing number of drop outs observed over time. Patient decision and lack of efficacy accounted for most treatment withdrawals. Treatment adherence is particularly crucial in patients with severe asthma considering the clinical impact of the disease and the cost of non-adherence. The risk of treatment discontinuation has to be carefully considered both in the experimental and real-life settings. Increased knowledge regarding the main reasons for patient withdrawal is important to improve adherence in clinical practice.

  18. A Delphi Study to Detect Deficiencies and Propose Actions in Real Life Treatment of Neovascular Age-Related Macular Degeneration

    Directory of Open Access Journals (Sweden)

    Alfredo García-Layana

    2014-01-01

    Full Text Available Purpose. Spanish retina specialists were surveyed in order to propose actions to decrease deficiencies in real-life neovascular age macular degeneration treatment (nv-AMD. Methods. One hundred experts, members of the Spanish Vitreoretinal Society (SERV, were invited to complete an online survey of 52 statements about nv-AMD management with a modified Delphi methodology. Four rounds were performed using a 5-point Linkert scale. Recommendations were developed after analyzing the differences between the results and the SERV guidelines recommendations. Results. Eighty-seven specialists completed all the Delphi rounds. Once major potential deficiencies in real-life nv-AMD treatment were identified, 15 recommendations were developed with a high level of agreement. Consensus statements to reduce the burden of the disease included the use of treat and extend regimen and to reduce the amount of diagnostic tests during the loading phase and training technical staff to perform these tests and reduce the time between relapse detection and reinjection, as well as establishing patient referral protocols to outside general ophthalmology clinics. Conclusion. The level of agreement with the final recommendations for nv-AMD treatment among Spanish retinal specialist was high indicating that some actions could be applied in order to reduce the deficiencies in real-life nv-AMD treatment.

  19. Self-disclosure through weblogs and perceptions of online and "real-life" friendships among female bloggers.

    Science.gov (United States)

    Bane, Cynthia M H; Cornish, Marilyn; Erspamer, Nicole; Kampman, Lia

    2010-04-01

    The current study examined female bloggers' perceptions of online and "real-life" same-sex friendships and examined relationships between self-disclosure through blogs and perceptions of the two types of friendships. Three hundred seven female bloggers (M age = 34.56 years) completed an online survey regarding friendship satisfaction and perceptions of intimacy-promoting interaction patterns in friendships. One hundred respondents' weblogs were analyzed for self-disclosure. Self-reported self-disclosure was positively correlated with number of online friendships and satisfaction with online friendships. Although participants reported having close online friends, they perceived real-life friendships as more likely than online friendships to possess intimacy-promoting interaction patterns. These perceptions did not differ as a function of self-disclosure through blogging, although bloggers who were categorized as higher in disclosure were more satisfied with online friendships than were bloggers who were categorized as lower in disclosure. These results suggest a relationship between self-disclosure through blogging and online relationship satisfaction among women in middle adulthood but that these women perceive real-life friendships as more likely to offer interaction patterns that foster intimacy.

  20. Real-life memory and spatial navigation in patients with focal epilepsy: ecological validity of a virtual reality supermarket task.

    Science.gov (United States)

    Grewe, P; Lahr, D; Kohsik, A; Dyck, E; Markowitsch, H J; Bien, C G; Botsch, M; Piefke, M

    2014-02-01

    Ecological assessment and training of real-life cognitive functions such as visual-spatial abilities in patients with epilepsy remain challenging. Some studies have applied virtual reality (VR) paradigms, but external validity of VR programs has not sufficiently been proven. Patients with focal epilepsy (EG, n=14) accomplished an 8-day program in a VR supermarket, which consisted of learning and buying items on a shopping list. Performance of the EG was compared with that of healthy controls (HCG, n=19). A comprehensive neuropsychological examination was administered. Real-life performance was investigated in a real supermarket. Learning in the VR supermarket was significantly impaired in the EG on different VR measures. Delayed free recall of products did not differ between the EG and the HCG. Virtual reality scores were correlated with neuropsychological measures of visual-spatial cognition, subjective estimates of memory, and performance in the real supermarket. The data indicate that our VR approach allows for the assessment of real-life visual-spatial memory and cognition in patients with focal epilepsy. The multimodal, active, and complex VR paradigm may particularly enhance visual-spatial cognitive resources. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Effects of Healthy Aging and Mild Cognitive Impairment on a Real-Life Decision-Making Task.

    Science.gov (United States)

    Pertl, Marie-Theres; Benke, Thomas; Zamarian, Laura; Delazer, Margarete

    2017-01-01

    In this study, we investigated the effects of age and of mild cognitive impairment (MCI) on decision making under risk by adopting a task representing real-life health-related situations and involving complex numerical information. Moreover, we assessed the relationship of real-life decision making to other cognitive functions such as number processing, executive functions, language, memory, and attention. For this reason, we compared the performance of 19 healthy, relatively younger adults with that of 18 healthy older adults and the performance of the 18 healthy older adults with that of 17 patients with MCI. Results indicated difficulties in real-life decision making for the healthy older adults compared with the healthy, relatively younger adults. Difficulties of patients with MCI relative to the healthy older adults arose in particular in difficult items requiring processing of frequencies and fractions. Significant effects of age and of MCI in processing frequencies were also evident in a ratio number comparison task. Decision-making performance of healthy participants and of the patient group correlated significantly with number processing. There was a further significant correlation with executive functions for the healthy participants and with reading comprehension for the patients. Our results suggest that healthy older individuals and patients with MCI make less advantageous decisions when the information is complex and high demands are put on executive functions and numerical abilities. Moreover, we show that executive functions and numerical abilities are not only essential in laboratory gambling tasks but also in more realistic and ecological decision situations within the health context.

  2. Deceleration during 'real life' motor vehicle collisions – a sensitive predictor for the risk of sustaining a cervical spine injury?

    Directory of Open Access Journals (Sweden)

    Hartwig Erich

    2009-03-01

    Full Text Available Abstract Background The predictive value of trauma impact for the severity of whiplash injuries has mainly been investigated in sled- and crash-test studies. However, very little data exist for real-life accidents. Therefore, the predictive value of the trauma impact as assessed by the change in velocity of the car due to the collision (ΔV for the resulting cervical spine injuries were investigated in 57 cases after real-life car accidents. Methods ΔV was determined for every car and clinical findings related to the cervical spine were assessed and classified according to the Quebec Task Force (QTF. Results In our study, 32 (56% subjects did not complain about symptoms and were therefore classified as QTF grade 0; 25 (44% patients complained of neck pain: 8 (14% were classified as QTF grade I, 6 (10% as QTF grade II, and 11 (19% as QTF grade IV. Only a slight correlation (r = 0.55 was found between the reported pain and ΔV. No relevant correlation was found between ΔV and the neck disability index (r = 0.46 and between ΔV and the QTF grade (r = 0.45 for any of the collision types. There was no ΔV threshold associated with acceptable sensitivity and specificity for the prognosis of a cervical spine injury. Conclusion The results of this study indicate that ΔV is not a conclusive predictor for cervical spine injury in real-life motor vehicle accidents. This is of importance for surgeons involved in medicolegal expertise jobs as well as patients who suffer from whiplash-associated disorders (WADs after motor vehicle accidents. Trial registration The study complied with applicable German law and with the principles of the Helsinki Declaration and was approved by the institutional ethics commission.

  3. [Required Framework for the Collection of Real-life Data: An Example from University Eye Hospital Munich].

    Science.gov (United States)

    Kortüm, Karsten; Kern, Christoph; Meyer, Gerhard; Priglinger, Siegfried; Hirneiß, Christoph

    2017-12-01

    Background The importance of evaluating real-life data is constantly increasing. Currently available computer systems better allow for analyses of data, as more and more data is available in a digital form. Before a project for real-life data analyses is started, technical considerations and staff, legal, and data protection procedures need to be addressed. In this manuscript, experiences made at the University Eye Hospital in Munich will be shared. Materials and Methods Legal requirements, as found in laws and guidelines governing documentation and data privacy, are highlighted. Technical requirements for information technology infrastructure and software are defined. A survey conducted by the German Ophthalmological Society, among German eye hospitals investigating the current state of digitalization, was conducted. Also, staff requirements are outlined. Results A database comprising results of 330,801 patients was set up. It includes all diagnoses, procedures, clinical findings and results from diagnostic devices. This database was approved by the local data protection officer. In less than half of German eye hospitals (n = 21) that participated in the survey (n = 54), a complete electronic documentation is done. Fourteen institutions are completely paper-based, and the remainder of the hospitals used a mixed system. Conclusion In this work, we examined the framework that is required to develop a comprehensive database containing real-life data from clinics. In future, these databases will become increasingly important as more and more innovation are made in decision support systems. The base for this is comprehensive and well-curated databases. Georg Thieme Verlag KG Stuttgart · New York.

  4. Psychosocial stress based on public speech in humans: is there a real life/laboratory setting cross-adaptation?

    Science.gov (United States)

    Jezova, D; Hlavacova, N; Dicko, I; Solarikova, P; Brezina, I

    2016-07-01

    Repeated or chronic exposure to stressors is associated with changes in neuroendocrine responses depending on the type, intensity, number and frequency of stress exposure as well as previous stress experience. The aim of the study was to test the hypothesis that salivary cortisol and cardiovascular responses to real-life psychosocial stressors related to public performance can cross-adapt with responses to psychosocial stress induced by public speech under laboratory setting. The sample consisted of 22 healthy male volunteers, which were either actors, more precisely students of dramatic arts or non-actors, students of other fields. The stress task consisted of 15 min anticipatory preparation phase and 15 min of public speech on an emotionally charged topic. The actors, who were accustomed to public speaking, responded with a rise in salivary cortisol as well as blood pressure to laboratory public speech. The values of salivary cortisol, systolic blood pressure and state anxiety were lower in actors compared to non-actors. Unlike non-actors, subjects with experience in public speaking did not show stress-induced rise in the heart rate. Evaluation of personality traits revealed that actors scored significantly higher in extraversion than the subjects in the non-actor group. In conclusion, neuroendocrine responses to real-life stressors in actors can partially cross-adapt with responses to psychosocial stress under laboratory setting. The most evident adaptation was at the level of heart rate responses. The public speech tasks may be of help in evaluation of the ability to cope with stress in real life in artists by simple laboratory testing.

  5. Comparison of cortical activation during Mahjong game play in a video game setting and a real-life setting

    OpenAIRE

    Fujimori, Satomi; Terasawa, Koji; Murata, Yuki; Ogawa, Kishiko; Tabuchi, Hisaaki; Yanagisawa, Hiroki; Terasawa, Saiki; Shinohara, Kikunori; Yanagisawa, Akitaka

    2015-01-01

    The purpose of this study was to compare the hemodynamic changes that occur during Mahjong game play in virtual and real-life settings. Fourteen healthy right-handed men (average age ± standard deviation; 36.7 ± 14.9 years) played: 1) a Mahjong solitaire game on a video console against virtual rivals; 2) a Mahjong game against human opponents without conversation; and 3) a Mahjong game against human opponents with conversation. We measured oxygenated hemoglobin concentration at 44 locations o...

  6. Healthy food choices are happy food choices : evidence from a real life sample using smartphone based assessments

    OpenAIRE

    Wahl, Deborah R.; Villinger, Karoline; König, Laura M.; Ziesemer, Katrin; Schupp, Harald T.; Renner, Britta

    2017-01-01

    Research suggests that "healthy" food choices such as eating fruits and vegetables have not only physical but also mental health benefits and might be a long-term investment in future well-being. This view contrasts with the belief that high-caloric foods taste better, make us happy, and alleviate a negative mood. To provide a more comprehensive assessment of food choice and well-being, we investigated in-the-moment eating happiness by assessing complete, real life dietary behaviour across ei...

  7. Natalizumab treatment reduces fatigue in multiple sclerosis. Results from the TYNERGY trial; a study in the real life setting

    DEFF Research Database (Denmark)

    Svenningsson, Anders; Falk, Eva; Celius, Elisabeth G

    2013-01-01

    . The TYNERGY study aimed to further evaluate the effects of natalizumab treatment on MS-related fatigue. In this one-armed clinical trial including 195 MS patients, natalizumab was prescribed in a real-life setting, and a validated questionnaire, the Fatigue Scale for Motor and Cognitive functions (FSMC......), was used both before and after 12 months of treatment to evaluate a possible change in the fatigue experienced by the patients. In the treated cohort all measured variables, that is, fatigue score, quality of life, sleepiness, depression, cognition, and disability progression were improved from baseline...

  8. From real life to real life

    DEFF Research Database (Denmark)

    Svalgaard, Lotte

    2017-01-01

    In Action Learning programmes, it is held central to work on real business challenges (task) while learning about team and self (process); staying mindful aware of the process is referred to in this paper as ‘double awareness’, and emphasises noticing and acting on process cues while working on t...

  9. Personal attitudes toward time: The relationship between temporal focus, space-time mappings and real life experiences.

    Science.gov (United States)

    Li, Heng; Cao, Yu

    2017-06-01

    What influences how people implicitly associate "past" and "future" with "front" and "back?" Whereas previous research has shown that cultural attitudes toward time play a role in modulating space-time mappings in people's mental models (de la Fuente, Santiago, Román, Dumitrache & Casasanto, 2014), we investigated real life experiences as potential additional influences on these implicit associations. Participants within the same single culture, who are engaged in different intermediate-term educational experiences (Study 1), long-term living experiences (Study 2), and short-term visiting experiences (Study 3), showed their distinct differences in temporal focus, thereby influencing their implicit spatializations of time. Results across samples suggest that personal attitudes toward time related to real life experiences may influence people's space-time mappings. The findings we report on shed further light on the high flexibility of human conceptualization system. While culture may exert an important influence on temporal focus, a person's conceptualization of time may be attributed to a culmination of factors. © 2017 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

  10. Reversal of Dabigatran Using Idarucizumab in a Septic Patient with Impaired Kidney Function in Real-Life Practice

    Directory of Open Access Journals (Sweden)

    Thomas C. Sauter

    2016-01-01

    Full Text Available Background. Immediate reversal of anticoagulation is essential when facing severe bleeding or emergency surgery. Although idarucizumab is approved for the reversal of dabigatran in many countries, clinical experiences are lacking, particularly in special patient-populations such as sepsis and impaired renal function. Case Presentation. We present the case of a 67-year-old male septic patient with a multilocular facial abscess and chronic kidney disease (GFR 36.5 mL/min. Thrombin time (TT and activated partial thromboplastin time (aPTT 15 hours after the last intake of 150 mg dabigatran were both prolonged (>120 sec, resp., 61 sec, as well as unbound dabigatran concentration (119.05 ng/mL. Before immediate emergency surgery dabigatran was antagonised using idarucizumab 2 × 2.5 g. Dabigatran concentration was not detectable 10 min after idarucizumab administration (<30 ng/mL. TT and aPTT time were normalised (16.2 sec, resp., 30.2 sec. Sepsis was controlled after surgery and kidney function remained stable. In the absence of postoperative bleeding, dabigatran was restarted 36 hours after admission. Conclusion. Idarucizumab successfully reversed the effect of dabigatran in real-life practice in a patient with sepsis and renal impairment and allowed emergency surgery with normal haemostasis. Efficacy and safety in real-life practice will nevertheless require prospective registries monitoring.

  11. Description of Anomalous Noise Events for Reliable Dynamic Traffic Noise Mapping in Real-Life Urban and Suburban Soundscapes

    Directory of Open Access Journals (Sweden)

    Francesc Alías

    2017-02-01

    Full Text Available Traffic noise is one of the main pollutants in urban and suburban areas. European authorities have driven several initiatives to study, prevent and reduce the effects of exposure of population to traffic. Recent technological advances have allowed the dynamic computation of noise levels by means of Wireless Acoustic Sensor Networks (WASN such as that developed within the European LIFE DYNAMAP project. Those WASN should be capable of detecting and discarding non-desired sound sources from road traffic noise, denoted as anomalous noise events (ANE, in order to generate reliable noise level maps. Due to the local, occasional and diverse nature of ANE, some works have opted to artificially build ANE databases at the cost of misrepresentation. This work presents the production and analysis of a real-life environmental audio database in two urban and suburban areas specifically conceived for anomalous noise events’ collection. A total of 9 h 8 min of labelled audio data is obtained differentiating among road traffic noise, background city noise and ANE. After delimiting their boundaries manually, the acoustic salience of the ANE samples is automatically computed as a contextual signal-to-noise ratio (SNR. The analysis of the real-life environmental database shows high diversity of ANEs in terms of occurrences, durations and SNRs, as well as confirming both the expected differences between the urban and suburban soundscapes in terms of occurrences and SNRs, and the rare nature of ANE.

  12. Cybersex addiction: Experienced sexual arousal when watching pornography and not real-life sexual contacts makes the difference.

    Science.gov (United States)

    Laier, Christian; Pawlikowski, Mirko; Pekal, Jaro; Schulte, Frank P; Brand, Matthias

    2013-06-01

    Background and aims Cybersex addiction is discussed controversially, while empirical evidence is widely missing. With respect to its mechanisms of development and maintenance Brand et al. (2011) assume that reinforcement due to cybersex should lead to the development of cue-reactivity and craving explaining recurrent cybersex use in the face of growing but neglected negative consequences. To support this hypothesis, two experimental studies were conducted. Methods In a cue-reactivity paradigm 100 pornographic cues were presented to participants and indicators of sexual arousal and craving were assessed. The first study aimed at identifying predictors of cybersex addiction in a freely recruited sample of 171 heterosexual males. The aim of the second study was to verify the findings of the first study by comparing healthy (n = 25) and problematic (n = 25) cybersex users. Results The results show that indicators of sexual arousal and craving to Internet pornographic cues predicted tendencies towards cybersex addiction in the first study. Moreover, it was shown that problematic cybersex users report greater sexual arousal and craving reactions resulting from pornographic cue presentation. In both studies, the number and subjective quality of real-life sexual contacts were not associated to cybersex addiction. Discussion The results support the gratification hypothesis, which assumes reinforcement, learning mechanisms, and craving to be relevant processes in the development and maintenance of cybersex addiction. Poor or unsatisfying sexual real-life contacts cannot sufficiently explain cybersex addiction. Conclusions Positive reinforcement in terms of gratification plays a major role in cybersex addiction.

  13. Real-Life Treatment Paradigms Show Adalimumab Is Cost-Effective for the Management of Ulcerative Colitis

    Directory of Open Access Journals (Sweden)

    Candace L. Beilman

    2016-01-01

    Full Text Available Background. Adalimumab is effective for the maintenance of remission in patients with moderate-to-severe ulcerative colitis (UC. Currently, biologic therapies are used in cases where patients fail conventional medical therapies. If biologic therapies are not available, patients often choose to remain in an unwell state rather than undergo colectomy. Objective. The aim of the study was to evaluate the cost-effectiveness of adalimumab in patients with UC where adalimumab was readily available compared to not available. Methods. A previously validated Markov model was used to simulate disease progression of patients with UC who are corticosteroid-dependent and/or did not respond to thiopurine therapy. Utility scores and transition probabilities between health states were determined by using data from randomized controlled trials and real-life observational studies. Costs were obtained from the Ontario Case Costing Initiative and the Alberta Health Schedule of Medical Benefits. Results. The incremental cost-effectiveness ratios for readily available adalimumab treatment of UC were $40,000 and $59,000 per quality-adjusted life year, compared with ongoing medical therapy in an unwell state, at 5-year and 10-year treatment time horizons, respectively. Conclusion. Considering real-life patient preferences to avoid colectomy, adalimumab is cost-effective according to a willingness-to-pay threshold of $80,000 for treatment of UC.

  14. The Italian compassionate use of sofosbuvir in HCV patients waitlisted for liver transplantation: A national real-life experience.

    Science.gov (United States)

    Martini, Silvia; Donato, Maria Francesca; Mazzarelli, Chiara; Rendina, Maria; Visco-Comandini, Ubaldo; Filì, Daniela; Gianstefani, Alice; Fagiuoli, Stefano; Melazzini, Mario; Montilla, Simona; Pani, Luca; Petraglia, Sandra; Russo, Pierluigi; Trotta, Maria Paola; Carrai, Paola; Caraceni, Paolo

    2018-04-01

    This study aimed to assess the real-life clinical and virological outcomes of HCV waitlisted patients for liver transplantation (LT) who received sofosbuvir/ribavirin (SOF/R) within the Italian compassionate use program. Clinical and virological data were collected in 224 patients with decompensated cirrhosis and/or hepatocellular carcinoma (HCC) receiving daily SOF/R until LT or up a maximum of 48 weeks. Of 100 transplanted patients, 51 were HCV-RNA negative for >4 weeks before LT (SVR12: 88%) and 49 negative for <4 weeks or still viraemic at transplant: 34 patients continued treatment after LT (bridging therapy) (SVR12: 88%), while 15 stopped treatment (SVR12: 53%). 98 patients completed SOF/R without LT (SVR12: 73%). In patients with advanced decompensated cirrhosis (basal MELD ≥15 and/or C-P ≥B8), a marked improvement of the scores occurred in about 50% of cases and almost 20% of decompensated patients without HCC reached a condition suitable for inactivation and delisting. These real-life data indicate that in waitlisted patients: (i) bridging antiviral therapy can be an option for patients still viraemic or negative <4 weeks at LT; and (ii) clinical improvement to a condition suitable for delisting can occur even in patients with advanced decompensated cirrhosis. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Linking the microscopic view of chemistry to real-life experiences: Intertextuality in a high-school science classroom

    Science.gov (United States)

    Wu, Hsin-Kai

    2003-11-01

    Chemistry learning involves establishing conceptual relationships among macroscopic, microscopic, and symbolic representations. Employing the notion of intertextuality to conceptualize these relationships, this study investigates how class members interactionally construct meanings of chemical representations by connecting them to real-life experiences and how the teachers' content knowledge shapes their ways to coconstruct intertextual links with students. Multiple sources of data were collected over 7 weeks with a participation of 25 eleventh graders, an experienced teacher, and a student teacher. An examination of classroom discourse shows that the intertextual links between the microscopic view of chemistry and students' real-life experiences could be initiated by students and instigated by the teachers. The teachers applied several discursive strategies to scaffold students building meaningful links based on their prior knowledge and experiences. Additionally, the experienced teacher with stronger content knowledge tended to present links in both dialogic and monologic discourses. Yet, the relatively limited content knowledge did not necessarily constrain the student teacher's interactions with students. The findings of this study provide a backdrop for further research to explore how chemistry is learned and taught in a class through the social constructivist lens.

  16. The correlation between pedestrian injury severity in real-life crashes and Euro NCAP pedestrian test results.

    Science.gov (United States)

    Strandroth, Johan; Rizzi, Matteo; Sternlund, Simon; Lie, Anders; Tingvall, Claes

    2011-12-01

    The aim of the present study was to estimate the correlation between Euro NCAP pedestrian rating scores and injury outcome in real-life car-to-pedestrian crashes, with special focus on long-term disability. Another aim was to determine whether brake assist (BA) systems affect the injury outcome in real-life car-to-pedestrian crashes and to estimate the combined effects in injury reduction of a high Euro NCAP ranking score and BA. In the current study, the Euro NCAP pedestrian scoring was compared with the real-life outcome in pedestrian crashes that occurred in Sweden during 2003 to 2010. The real-life crash data were obtained from the data acquisition system Swedish Traffic Accident Data Acquisition (STRADA), which combines police records and hospital admission data. The medical data consisted of International Classification of Diseases (ICD) diagnoses and Abbreviated Injury Scale (AIS) scoring. In all, approximately 500 pedestrians submitted to hospital were included in the study. Each car model was coded according to Euro NCAP pedestrian scores. In addition, the presence or absence of BA was coded for each car involved. Cars were grouped according to their scoring. Injury outcomes were analyzed with AIS and, at the victim level, with permanent medical impairment. This was done by translating the injury scores for each individual to the risk of serious consequences (RSC) at 1, 5, and 10 percent risk of disability level. This indicates the total risk of a medical disability for each victim, given the severity and location of injuries. The mean RSC (mRSC) was then calculated for each car group and t-tests were conducted to falsify the null hypothesis at p ≤ .05 that the mRSC within the groups was equal. The results showed a significant reduction of injury severity for cars with better pedestrian scoring, although cars with a high score could not be studied due to lack of cases. The reduction in RSC for medium-performing cars in comparison with low-performing cars

  17. Test case for a near-surface repository

    International Nuclear Information System (INIS)

    Elert, M.; Jones, C.; Nilsson, L.B.; Skagius, K.; Wiborgh, M.

    1998-01-01

    A test case is presented for assessment of a near-surface disposal facility for radioactive waste. The case includes waste characterization and repository design, requirements and constraints in an assessment context, scenario development, model description and test calculations

  18. Sample test cases using the environmental computer code NECTAR

    International Nuclear Information System (INIS)

    Ponting, A.C.

    1984-06-01

    This note demonstrates a few of the many different ways in which the environmental computer code NECTAR may be used. Four sample test cases are presented and described to show how NECTAR input data are structured. Edited output is also presented to illustrate the format of the results. Two test cases demonstrate how NECTAR may be used to study radio-isotopes not explicitly included in the code. (U.K.)

  19. Sensitivity analysis methods and a biosphere test case implemented in EIKOS

    International Nuclear Information System (INIS)

    Ekstroem, P.A.; Broed, R.

    2006-05-01

    Computer-based models can be used to approximate real life processes. These models are usually based on mathematical equations, which are dependent on several variables. The predictive capability of models is therefore limited by the uncertainty in the value of these. Sensitivity analysis is used to apportion the relative importance each uncertain input parameter has on the output variation. Sensitivity analysis is therefore an essential tool in simulation modelling and for performing risk assessments. Simple sensitivity analysis techniques based on fitting the output to a linear equation are often used, for example correlation or linear regression coefficients. These methods work well for linear models, but for non-linear models their sensitivity estimations are not accurate. Usually models of complex natural systems are non-linear. Within the scope of this work, various sensitivity analysis methods, which can cope with linear, non-linear, as well as non-monotone problems, have been implemented, in a software package, EIKOS, written in Matlab language. The following sensitivity analysis methods are supported by EIKOS: Pearson product moment correlation coefficient (CC), Spearman Rank Correlation Coefficient (RCC), Partial (Rank) Correlation Coefficients (PCC), Standardized (Rank) Regression Coefficients (SRC), Sobol' method, Jansen's alternative, Extended Fourier Amplitude Sensitivity Test (EFAST) as well as the classical FAST method and the Smirnov and the Cramer-von Mises tests. A graphical user interface has also been developed, from which the user easily can load or call the model and perform a sensitivity analysis as well as uncertainty analysis. The implemented sensitivity analysis methods has been benchmarked with well-known test functions and compared with other sensitivity analysis software, with successful results. An illustration of the applicability of EIKOS is added to the report. The test case used is a landscape model consisting of several linked

  20. Sensitivity analysis methods and a biosphere test case implemented in EIKOS

    Energy Technology Data Exchange (ETDEWEB)

    Ekstroem, P.A.; Broed, R. [Facilia AB, Stockholm, (Sweden)

    2006-05-15

    Computer-based models can be used to approximate real life processes. These models are usually based on mathematical equations, which are dependent on several variables. The predictive capability of models is therefore limited by the uncertainty in the value of these. Sensitivity analysis is used to apportion the relative importance each uncertain input parameter has on the output variation. Sensitivity analysis is therefore an essential tool in simulation modelling and for performing risk assessments. Simple sensitivity analysis techniques based on fitting the output to a linear equation are often used, for example correlation or linear regression coefficients. These methods work well for linear models, but for non-linear models their sensitivity estimations are not accurate. Usually models of complex natural systems are non-linear. Within the scope of this work, various sensitivity analysis methods, which can cope with linear, non-linear, as well as non-monotone problems, have been implemented, in a software package, EIKOS, written in Matlab language. The following sensitivity analysis methods are supported by EIKOS: Pearson product moment correlation coefficient (CC), Spearman Rank Correlation Coefficient (RCC), Partial (Rank) Correlation Coefficients (PCC), Standardized (Rank) Regression Coefficients (SRC), Sobol' method, Jansen's alternative, Extended Fourier Amplitude Sensitivity Test (EFAST) as well as the classical FAST method and the Smirnov and the Cramer-von Mises tests. A graphical user interface has also been developed, from which the user easily can load or call the model and perform a sensitivity analysis as well as uncertainty analysis. The implemented sensitivity analysis methods has been benchmarked with well-known test functions and compared with other sensitivity analysis software, with successful results. An illustration of the applicability of EIKOS is added to the report. The test case used is a landscape model consisting of several

  1. Long-term treatment of ADHD with stimulants: A large observational study of real-life patients

    DEFF Research Database (Denmark)

    Powell, Shelagh G.; Thomsen, Per Hove; Frydenberg, Morten

    2011-01-01

    : The diversity of ADHD patients was evident from the comorbidity, age at start, comedication, and treatment needs over time. Dosages corresponded to guidelines in most patients, but some needed higher dosages or got along on lower dosages for long periods. Age at start and comorbidity influenced dosage......, and dosage was associated to differential outcome groups. Conclusion: The study findings underscored the diversity of ADHD patients and that individual factors should be taken into account when tailoring individual treatment schedules. Findings further showed that stimulant dosages are dynamic over time......Objective: To evaluate 410 real-life patients treated with stimulants and assessed systematically over several years. Method: Naturalistic observational study. A database was compiled on the basis of a review of the medical charts of patients attending a specialized ADHD clinic. Results...

  2. The real-life experience with cardiovascular complications in the first dose of fingolimod for multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Yara Dadalti Fragoso

    2014-09-01

    Full Text Available Fingolimod is a new and efficient treatment for multiple sclerosis (MS. The drug administration requires special attention to the first dose, since cardiovascular adverse events can be observed during the initial six hours of fingolimod ingestion. The present study consisted of a review of cardiovascular data on 180 patients with MS receiving the first dose of fingolimod. The rate of bradycardia in these patients was higher than that observed in clinical trials with very strict inclusion criteria for patients. There were less than 10% of cases requiring special attention, but no fatal cases. All but one patient continued the treatment after this initial dose. This is the first report on real-life administration of fingolimod to Brazilian patients with MS, and one of the few studies with these characteristics in the world.

  3. Productive criticism, Part 2: A new environment for criticism. Performance appraisals and other real-life situations.

    Science.gov (United States)

    Weisinger, H D

    1996-01-01

    Criticism affects almost all aspects of your job: the quality of work you do, how you feel about it, and your relationships with your boss, coworkers, and subordinates. Used productively, criticism is a powerful tool that helps you improve your work, enhance your working relationships, increase your job satisfaction, and achieve better overall results. Improperly used, it impedes performance, demoralizes you, discourages you from wanting to try again, and creates friction in the workplace. In short, the ability to give and take criticism significantly determines how well you do on the job. In Part 1, we explained how to use productive criticism as an opportunity for the growth and education of subordinates. In Part 2, we will examine how you can productively criticize superiors and peers. We will also offer new performance appraisal technics and examine real-life criticism situations.

  4. Healthy food choices are happy food choices: Evidence from a real life sample using smartphone based assessments.

    Science.gov (United States)

    Wahl, Deborah R; Villinger, Karoline; König, Laura M; Ziesemer, Katrin; Schupp, Harald T; Renner, Britta

    2017-12-06

    Research suggests that "healthy" food choices such as eating fruits and vegetables have not only physical but also mental health benefits and might be a long-term investment in future well-being. This view contrasts with the belief that high-caloric foods taste better, make us happy, and alleviate a negative mood. To provide a more comprehensive assessment of food choice and well-being, we investigated in-the-moment eating happiness by assessing complete, real life dietary behaviour across eight days using smartphone-based ecological momentary assessment. Three main findings emerged: First, of 14 different main food categories, vegetables consumption contributed the largest share to eating happiness measured across eight days. Second, sweets on average provided comparable induced eating happiness to "healthy" food choices such as fruits or vegetables. Third, dinner elicited comparable eating happiness to snacking. These findings are discussed within the "food as health" and "food as well-being" perspectives on eating behaviour.

  5. Grating-based guided-mode resonance devices and degradation of their performance in real-life conditions

    DEFF Research Database (Denmark)

    Ivinskaya, Aliaksandra; Bergmann, René; Kafka, Jan Robert

    2014-01-01

    Guided-mode resonances in structures having periodicity along at least one dimension were widely employed in the last decade in various optical devices. Initially it was shown that at frequencies close to the second order band gap periodic structures can feature total reflection of light due...... to the guided modes propagating along the surface of the grating. As an application, this allows to substitute a thick multilayer Bragg mirror in VCSELs by a thin grating-based mirror. Most devices utilizing guided-mode resonances were theoretically and numerically investigated with the idealized model...... of an infinite periodic structure illuminated by a plane wave. To see how grating-based components can perform in real life we take into account two critical factors: the finite size of the grating and the Gaussian shape of the light source replacing a plane wave. These factors can significantly change...

  6. The fragrance hand immersion study - an experimental model simulating real-life exposure for allergic contact dermatitis on the hands

    DEFF Research Database (Denmark)

    Heydorn, S; Menné, T; Andersen, K E

    2003-01-01

    previously diagnosed with hand eczema to explore whether immersion of fingers in a solution with or without the patch-test-positive fragrance allergen would cause or exacerbate hand eczema on the exposed finger. The study was double blinded and randomized. All participants had a positive patch test to either...... hydroxycitronellal or Lyral (hydroxyisohexyl 3-cyclohexene carboxaldehyde). Each participant immersed a finger from each hand, once a day, in a solution containing the fragrance allergen or placebo. During the first 2 weeks, the concentration of fragrance allergen in the solution was low (approximately 10 p...... meter. 3 of 15 hand eczema patients developed eczema on the finger immersed in the fragrance-containing solution, 3 of 15 on the placebo finger and 3 of 15 on both fingers. Using this experimental exposure model simulating real-life exposure, we found no association between immersion of a finger...

  7. Rehabilitation of Executive Functions in a Real-Life Setting: Goal Management Training Applied to a Person with Schizophrenia

    Directory of Open Access Journals (Sweden)

    M.-N. Levaux

    2012-01-01

    Full Text Available The aim was to assess the efficacy of a modified version of Goal Management Training (GMT in a person with schizophrenia who had difficulties in attaining the final goal for new and multitasking daily-life situations. GMT is designed to improve abilities in establishing goal-directed plans and carrying them out effectively. Beneficial effects of GMT were measured for several clinical questionnaires, laboratory tasks, and three real-life situations: meal preparation (trained, familiar; washing (nontrained, familiar; meeting preparation (nontrained, unfamiliar. The results revealed improvement in planning and on trained laboratory and meal preparation tasks and a generalization of GMT effects on nontrained laboratory and everyday tasks. Self-esteem also improved. Finally, a two-year followup indicated the durability of the beneficial effects.

  8. The fragrance hand immersion study - an experimental model simulating real-life exposure for allergic contact dermatitis on the hands.

    Science.gov (United States)

    Heydorn, S; Menné, T; Andersen, K E; Bruze, M; Svedman, C; Basketter, D; Johansen, J D

    2003-06-01

    Recently, we showed that 10 x 2% of consecutively patch-tested hand eczema patients had a positive patch test to a selection of fragrances containing fragrances relevant to hand exposure. In this study, we used repeated skin exposure to a patch test-positive fragrance allergen in patients previously diagnosed with hand eczema to explore whether immersion of fingers in a solution with or without the patch-test-positive fragrance allergen would cause or exacerbate hand eczema on the exposed finger. The study was double blinded and randomized. All participants had a positive patch test to either hydroxycitronellal or Lyral (hydroxyisohexyl 3-cyclohexene carboxaldehyde). Each participant immersed a finger from each hand, once a day, in a solution containing the fragrance allergen or placebo. During the first 2 weeks, the concentration of fragrance allergen in the solution was low (approximately 10 p.p.m.), whilst during the following 2 weeks, the concentration was relatively high (approximately 250 p.p.m.), imitating real-life exposure to a household product like dishwashing liquid diluted in water and the undiluted product, respectively. Evaluation was made using a clinical scale and laser Doppler flow meter. 3 of 15 hand eczema patients developed eczema on the finger immersed in the fragrance-containing solution, 3 of 15 on the placebo finger and 3 of 15 on both fingers. Using this experimental exposure model simulating real-life exposure, we found no association between immersion of a finger in a solution containing fragrance and development of clinically visible eczema on the finger in 15 participants previously diagnosed with hand eczema and with a positive patch test to the fragrance in question.

  9. A Novel Computational Tool for Mining Real-Life Data: Application in the Metastatic Colorectal Cancer Care Setting.

    Science.gov (United States)

    Siegelmann-Danieli, Nava; Farkash, Ariel; Katzir, Itzhak; Vesterman Landes, Janet; Rotem Rabinovich, Hadas; Lomnicky, Yossef; Carmeli, Boaz; Parush-Shear-Yashuv, Naama

    2016-01-01

    Randomized clinical trials constitute the gold-standard for evaluating new anti-cancer therapies; however, real-life data are key in complementing clinically useful information. We developed a computational tool for real-life data analysis and applied it to the metastatic colorectal cancer (mCRC) setting. This tool addressed the impact of oncology/non-oncology parameters on treatment patterns and clinical outcomes. The developed tool enables extraction of any computerized information including comorbidities and use of drugs (oncological/non-oncological) per individual HMO member. The study in which we evaluated this tool was a retrospective cohort study that included Maccabi Healthcare Services members with mCRC receiving bevacizumab with fluoropyrimidines (FP), FP plus oxaliplatin (FP-O), or FP plus irinotecan (FP-I) in the first-line between 9/2006 and 12/2013. The analysis included 753 patients of whom 15.4% underwent subsequent metastasectomy (the Surgery group). For the entire cohort, median overall survival (OS) was 20.5 months; in the Surgery group, median duration of bevacizumab-containing therapy (DOT) pre-surgery was 6.1 months; median OS was not reached. In the Non-surgery group, median OS and DOT were 18.7 and 11.4 months, respectively; no significant OS differences were noted between FP-O and FP-I, whereas FP use was associated with shorter OS (12.3 month; p controlling for age and gender) identified several non-oncology parameters associated with poorer clinical outcomes including concurrent use of diuretics and proton-pump inhibitors. Our tool provided insights that confirmed/complemented information gained from randomized-clinical trials. Prospective tool implementation is warranted.

  10. Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys.

    Science.gov (United States)

    Rannou, François; Pelletier, Jean-Pierre; Martel-Pelletier, Johanne

    2016-02-01

    Topical non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in international and national guidelines as an early treatment option for the symptomatic management of knee and hand osteoarthritis (OA), and may be used ahead of oral NSAIDs due to their superior safety profile. The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends topical NSAIDs for knee OA in addition to the pharmacological background of symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) and rescue analgesia with paracetamol and non-pharmacological treatment, if the patient is still symptomatic. Topical NSAIDs have a moderate effect on pain relief, with efficacy similar to that of oral NSAIDs, with the advantage of a better risk:benefit ratio. In real-life studies, topical and oral NSAIDs demonstrate an equivalent effect on knee pain over 1 year of treatment, with fewer adverse events due to lower systemic absorption of topical NSAIDs compared with oral NSAIDs. As a result, topical NSAIDs may be the preferred treatment option, especially in OA patients aged ≥75 years, and those with co-morbidities or at an increased risk of cardiovascular, gastrointestinal, or renal side effects. Furthermore, using topical NSAIDs in inflammatory rheumatic diseases leads to a 40% reduction in the need for concomitant oral NSAIDs. When selecting a topical NSAID, absorption and bioavailability are important because of heterogeneity among topical drug formulations. Molecules like etofenamate have a bioavailability of >20% and evidence for accumulation in synovial tissues, with efficacy demonstrated as improvement in pain and function in real-life studies of OA patients. Diclofenac also shows good efficacy alongside evidence that diclofenac accumulates in the synovium. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  11. Physiologically based pharmacokinetic toolkit to evaluate environmental exposures: Applications of the dioxin model to study real life exposures

    Energy Technology Data Exchange (ETDEWEB)

    Emond, Claude, E-mail: claude.emond@biosmc.com [BioSimulation Consulting Inc, Newark, DE (United States); Ruiz, Patricia; Mumtaz, Moiz [Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Atlanta, GA (United States)

    2017-01-15

    Chlorinated dibenzo-p-dioxins (CDDs) are a series of mono- to octa-chlorinated homologous chemicals commonly referred to as polychlorinated dioxins. One of the most potent, well-known, and persistent member of this family is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). As part of translational research to make computerized models accessible to health risk assessors, we present a Berkeley Madonna recoded version of the human physiologically based pharmacokinetic (PBPK) model used by the U.S. Environmental Protection Agency (EPA) in the recent dioxin assessment. This model incorporates CYP1A2 induction, which is an important metabolic vector that drives dioxin distribution in the human body, and it uses a variable elimination half-life that is body burden dependent. To evaluate the model accuracy, the recoded model predictions were compared with those of the original published model. The simulations performed with the recoded model matched well with those of the original model. The recoded model was then applied to available data sets of real life exposure studies. The recoded model can describe acute and chronic exposures and can be useful for interpreting human biomonitoring data as part of an overall dioxin and/or dioxin-like compounds risk assessment. - Highlights: • The best available dioxin PBPK model for interpreting human biomonitoring data is presented. • The original PBPK model was recoded from acslX to the Berkeley Madonna (BM) platform. • Comparisons were made of the accuracy of the recoded model with the original model. • The model is a useful addition to the ATSDR's BM based PBPK toolkit that supports risk assessors. • The application of the model to real-life exposure data sets is illustrated.

  12. Treatment Efficacy and Compliance in Patients with Diabetic Macular Edema Treated with Ranibizumab in a Real-Life Setting

    Directory of Open Access Journals (Sweden)

    Anne-Laurence Best

    2018-01-01

    Full Text Available Purpose. To assess real-life efficacy of ranibizumab and treatment compliance of patients with vision loss secondary to diabetic macular edema (DME. Methods. A retrospective study was conducted in DME patients treated with ranibizumab. Patients were monitored every 4 weeks for visual acuity (VA and central retinal thickness (CRT by SD-OCT. All patients received a loading dose of 3 monthly injections followed by retreatments on an as-needed basis. The primary endpoint was the change in VA at M12. Patient compliance to the follow-up and the correlation between the injection number and VA were also investigated. Compliance was compared to that of neovascular age-related macular degeneration (nAMD patients. Results. Seventy-two eyes of 55 consecutive DME patients were included. At baseline, the mean VA was 56.5 letters and CRT was 470 μm. At M12, the mean VA was 63.4 letters (p 70 letters, the mean VA change was +6.9 letters, and the mean CRT was 361.9 μm (p=0.0001 after a mean number of 5.33 intravitreal injections. In patients who received ≥7 injections, the VA gain and final VA were significantly higher than in patients who received <7 injections. At M12, 25.45% of DME patients were lost to follow-up versus 16.8% of nAMD patients (n=55. Discussion/Conclusion. Our study confirms the real-life efficacy of ranibizumab in DME at M12 and the need for a large number of injections to achieve better visual outcomes. We also showed a trend to a lower compliance in diabetic versus nAMD patients.

  13. The frequency and determinants of liver stiffness measurement failure: a retrospective study of "real-life" 38,464 examinations.

    Directory of Open Access Journals (Sweden)

    Dong Ji

    Full Text Available To investigate the frequency and determinants of liver stiffness measurement (LSM failure by means of FibroScan in "real-life" Chinese patients.A total of 38,464 "real-life" Chinese patients in 302 military hospital of China through the whole year of 2013, including asymptomatic carrier, chronic hepatitis B, chronic hepatitis C, liver cirrhosis (LC, alcoholic liver disease, autoimmune liver disease, hepatocellular carcinoma (HCC and other, were enrolled, their clinical and biological parameters were retrospectively investigated. Liver fibrosis was evaluated by FibroScan detection. S probe (for children with height less than 1.20 m and M probe (for adults were used. LSM failure defined as zero valid shots (unsuccessful LSM, or the ratio of the interquartile range to the median of 10 measurements (IQR/M greater than 0.30 plus median LSM greater or equal to 7.1 kPa (unreliable LSM.LSM failure occurred in 3.34% of all examinations (1286 patients out of 38,464, among them, there were 958 cases (2.49% with unsuccessful LSM, and 328 patients (0.85% with unreliable LSM. Statistical analyses showed that LSM failure was independently associated with body mass index (BMI greater than 30 kg/m(2, female sex, age greater than 50 years, intercostal spaces (IS less than 9 mm, decompensated liver cirrhosis and HCC patients. There were no significant differences among other diseases. By changing another skilled operator, success was achieved on 301 cases out of 1286, which reduced the failure rate to 2.56%, the decrease was significant (P<0.0001.The principal reasons of LSM failure are ascites, obesity and narrow of IS. The failure rates of HCC, decompensated LC, elder or female patients are higher. These results emphasize the need for adequate operator training, technological improvements and optimal criteria for specific patient subpopulations.

  14. Validation test case generation based on safety analysis ontology

    International Nuclear Information System (INIS)

    Fan, Chin-Feng; Wang, Wen-Shing

    2012-01-01

    Highlights: ► Current practice in validation test case generation for nuclear system is mainly ad hoc. ► This study designs a systematic approach to generate validation test cases from a Safety Analysis Report. ► It is based on a domain-specific ontology. ► Test coverage criteria have been defined and satisfied. ► A computerized toolset has been implemented to assist the proposed approach. - Abstract: Validation tests in the current nuclear industry practice are typically performed in an ad hoc fashion. This study presents a systematic and objective method of generating validation test cases from a Safety Analysis Report (SAR). A domain-specific ontology was designed and used to mark up a SAR; relevant information was then extracted from the marked-up document for use in automatically generating validation test cases that satisfy the proposed test coverage criteria; namely, single parameter coverage, use case coverage, abnormal condition coverage, and scenario coverage. The novelty of this technique is its systematic rather than ad hoc test case generation from a SAR to achieve high test coverage.

  15. Measuring Test Case Similarity to Support Test Suite Understanding

    NARCIS (Netherlands)

    Greiler, M.S.; Van Deursen, A.; Zaidman, A.E.

    2012-01-01

    Preprint of paper published in: TOOLS 2012 - Proceedings of the 50th International Conference, Prague, Czech Republic, May 29-31, 2012; doi:10.1007/978-3-642-30561-0_8 In order to support test suite understanding, we investigate whether we can automatically derive relations between test cases. In

  16. Test case for a near-surface repository

    Energy Technology Data Exchange (ETDEWEB)

    Elert, M.; Jones, C. [Kemakta Konsult AB, Stockholm (Sweden); Nilsson, L.B. [Swedish Nuclear Fuel and Waste Co, Stockholm (Sweden); Skagius, K.; Wiborgh, M. [Kemakta Konsult AB, Stockholm (Sweden)

    1998-09-01

    A test case is presented for assessment of a near-surface disposal facility for radioactive waste. The case includes waste characterization and repository design, requirements and constraints in an assessment context, scenario development, model description and test calculations 6 refs, 12 tabs, 16 figs

  17. Couplex1 test case nuclear - Waste disposal far field simulation

    International Nuclear Information System (INIS)

    2001-01-01

    This first COUPLEX test case is to compute a simplified Far Field model used in nuclear waste management simulation. From the mathematical point of view the problem is of convection diffusion type but the parameters are highly varying from one layer to another. Another particularity is the very concentrated nature of the source, both in space and in time. (author)

  18. Gifted and Talented Education: A National Test Case in Peoria.

    Science.gov (United States)

    Fetterman, David M.

    1986-01-01

    This article presents a study of a program in Peoria, Illinois, for the gifted and talented that serves as a national test case for gifted education and minority enrollment. It was concluded that referral, identification, and selection were appropriate for the program model but that inequalities resulted from socioeconomic variables. (Author/LMO)

  19. Test cases for interface tracking methods: methodology and current status

    International Nuclear Information System (INIS)

    Lebaigue, O.; Jamet, D.; Lemonnier, E.

    2004-01-01

    Full text of publication follows:In the past decade, a large number of new methods have been developed to deal with interfaces in the numerical simulation of two-phase flows. We have collected a set of 36 test cases, which can be seen as a tool to help engineers and researchers selecting the most appropriate method(s) for their specific fields of application. This set can be use: - To perform an initial evaluation of the capabilities of available methods with regard to the specificity of the final application and the most important features to be recovered from the simulation. - To measure the maximum mesh size to be used for a given physical problem in order to obtain an accurate enough solution. - To assess and quantify the performances of a selected method equipped with its set of physical models. The computation of a well-documented test case allows estimating the error due to the numerical technique by comparison with reference solutions. This process is compulsory to gain confidence and credibility on the prediction capabilities of a numerical method and its physical models. - To broaden the capabilities of a given numerical technique. The test cases may be used to identify the need for improvement of the overall numerical scheme or to determine the physical part of the model, which is responsible for the observed limitations. Each test case falls within one of the following categories: - Analytical solutions of well-known sets of equations corresponding to simple geometrical situations. - Reference numerical solutions of moderately complex problems, produced by accurate methods (e.g., boundary Fitted coordinate method) on refined meshes. - Separate effects analytical experiments. The presentation will suggest how to use the test cases for assessing the physical models and the numerical methods. The expected fallout of using test cases is indeed on the one hand to identify the merits of existing methods and on the other hand to orient further research towards

  20. The potential of clustering methods to define intersection test scenarios: Assessing real-life performance of AEB.

    Science.gov (United States)

    Sander, Ulrich; Lubbe, Nils

    2018-04-01

    Intersection accidents are frequent and harmful. The accident types 'straight crossing path' (SCP), 'left turn across path - oncoming direction' (LTAP/OD), and 'left-turn across path - lateral direction' (LTAP/LD) represent around 95% of all intersection accidents and one-third of all police-reported car-to-car accidents in Germany. The European New Car Assessment Program (Euro NCAP) have announced that intersection scenarios will be included in their rating from 2020; however, how these scenarios are to be tested has not been defined. This study investigates whether clustering methods can be used to identify a small number of test scenarios sufficiently representative of the accident dataset to evaluate Intersection Automated Emergency Braking (AEB). Data from the German In-Depth Accident Study (GIDAS) and the GIDAS-based Pre-Crash Matrix (PCM) from 1999 to 2016, containing 784 SCP and 453 LTAP/OD accidents, were analyzed with principal component methods to identify variables that account for the relevant total variances of the sample. Three different methods for data clustering were applied to each of the accident types, two similarity-based approaches, namely Hierarchical Clustering (HC) and Partitioning Around Medoids (PAM), and the probability-based Latent Class Clustering (LCC). The optimum number of clusters was derived for HC and PAM with the silhouette method. The PAM algorithm was both initiated with random start medoid selection and medoids from HC. For LCC, the Bayesian Information Criterion (BIC) was used to determine the optimal number of clusters. Test scenarios were defined from optimal cluster medoids weighted by their real-life representation in GIDAS. The set of variables for clustering was further varied to investigate the influence of variable type and character. We quantified how accurately each cluster variation represents real-life AEB performance using pre-crash simulations with PCM data and a generic algorithm for AEB intervention. The

  1. The International intraval project. Phase 1 test cases

    International Nuclear Information System (INIS)

    1992-01-01

    This report contains a description of the test cases adopted in Phase 1 of the international cooperation project INTRAVAL. Seventeen test cases based on bench-scale experiments in laboratory, field tests and natural analogue studies, have been included in the study. The test cases are described in terms of experimental design and types of available data. In addition, some quantitative examples of available data are given as well as references to more extensive documentation of the experiments on which the test cases are based. Fithteen test cases examples are given: 1 Mass transfer through clay by diffusion and advection. 2 Uranium migration in crystalline bore cores, small scale pressure infiltration experiments. 3 Radionuclide migration in single natural fractures in granite. 4 Tracer tests in a deep basalt flow top. 5 Flow and tracer experiment in crystalline rock based on the Stripa 3-D experiment. 6 Tracer experiment in a fracture zone at the Finnsjon research area. 7 Synthetic data base, based on single fracture migration experiments in Grimsel rock laboratory. 8 Natural analogue studies at Pocos de Caldas, Minais Gerais, Brazil. Redox-front and radionuclide movement in an open pit uranium mine. 9 Natural analogue studies at the Koongarra site in the Alligator Rivers area of the Northern Territory, Australia. 10 Large block migration experiments in a block of crystalline rock. 11 Unsaturated flow and transport experiments performed at Las Cruces, New Mexico. 12 Flow and transport experiment in unsaturated fractured rock performed at the Apache Leap Tuff site, Arizona. 13 Experiments in partially saturated tuffaceous rocks performed in the G-tunnel underground facility at the Nevada Test site, USA. 14 Experimental study of brine transport in porous media. 15 Groundwater flow in the vicinity of the Gorleben Salt Dome, Federal Republic of Germany

  2. A Novel Computational Tool for Mining Real-Life Data: Application in the Metastatic Colorectal Cancer Care Setting.

    Directory of Open Access Journals (Sweden)

    Nava Siegelmann-Danieli

    Full Text Available Randomized clinical trials constitute the gold-standard for evaluating new anti-cancer therapies; however, real-life data are key in complementing clinically useful information. We developed a computational tool for real-life data analysis and applied it to the metastatic colorectal cancer (mCRC setting. This tool addressed the impact of oncology/non-oncology parameters on treatment patterns and clinical outcomes.The developed tool enables extraction of any computerized information including comorbidities and use of drugs (oncological/non-oncological per individual HMO member. The study in which we evaluated this tool was a retrospective cohort study that included Maccabi Healthcare Services members with mCRC receiving bevacizumab with fluoropyrimidines (FP, FP plus oxaliplatin (FP-O, or FP plus irinotecan (FP-I in the first-line between 9/2006 and 12/2013.The analysis included 753 patients of whom 15.4% underwent subsequent metastasectomy (the Surgery group. For the entire cohort, median overall survival (OS was 20.5 months; in the Surgery group, median duration of bevacizumab-containing therapy (DOT pre-surgery was 6.1 months; median OS was not reached. In the Non-surgery group, median OS and DOT were 18.7 and 11.4 months, respectively; no significant OS differences were noted between FP-O and FP-I, whereas FP use was associated with shorter OS (12.3 month; p <0.002; notably, these patients were older. Patients who received both FP-O- and FP-I-based regimens achieved numerically longer OS vs. those who received only one of these regimens (22.1 [19.9-24.0] vs. 18.9 [15.5-21.9] months. Among patients assessed for wild-type KRAS and treated with subsequent anti-EGFR agent, OS was 25.4 months and 18.7 months for 124 treated vs. 37 non-treated patients (non-significant. Cox analysis (controlling for age and gender identified several non-oncology parameters associated with poorer clinical outcomes including concurrent use of diuretics and proton

  3. A Proficiency Based Stepwise Endovascular Curricular Training (PROSPECT) Program Enhances Operative Performance in Real Life: A Randomised Controlled Trial.

    Science.gov (United States)

    Maertens, H; Aggarwal, R; Moreels, N; Vermassen, F; Van Herzeele, I

    2017-09-01

    Healthcare evolution requires optimisation of surgical training to provide safe patient care. Operating room performance after completion of proficiency based training in vascular surgery has not been investigated. A randomised controlled trial evaluated the impact of a Proficiency based Stepwise Endovascular Curricular Training program (PROSPECT) on the acquisition of endovascular skills and the transferability of these skills to real life interventions. All subjects performed two endovascular interventions treating patients with symptomatic iliac and/or superficial femoral artery stenosis under supervision. Primary outcomes were technical performances (Global Rating Scale [GRS]; Examiner Checklist), operative metrics, and patient outcomes, adjusted for case difficulty and trainee experience. Secondary outcomes included knowledge and technical performance after 6 weeks and 3 months. Thirty-two general surgical trainees were randomised into three groups. Besides traditional training, the first group (n = 11) received e-learning and simulation training (PROSPECT), the second group (n = 10) only had access to e-learning, while controls (n = 11) did not receive supplementary training. Twenty-nine trainees (3 dropouts) performed 58 procedures. Trainees who completed PROSPECT showed superior technical performance (GRS 39.36 ± 2.05; Checklist 63.51 ± 3.18) in real life with significantly fewer supervisor takeovers compared with trainees receiving e-learning alone (GRS 28.42 ± 2.15; p = .001; Checklist 53.63 ± 3.34; p = .027) or traditional education (GRS 23.09 ± 2.18; p = .001; Checklist 38.72 ± 3.38; p = .001). Supervisors felt more confident in allowing PROSPECT trained physicians to perform basic (p = .006) and complex (p = .003) procedures. No differences were detected in procedural parameters (such as fluoroscopy time, DAP, procedure time, etc.) or complications. Proficiency levels were maintained up to 3 months. A structured

  4. Comparison of nocturia response to desmopressin treatment in elderly men with and without nocturnal polyuria in real-life practice.

    Science.gov (United States)

    Chen, S-L; Huang, Y-H; Hung, T-W; Ou, Y-C

    2016-05-01

    To evaluate the safety and efficacy of low-dose desmopressin in elderly men with and without nocturnal polyuria (NP) in real-life practice. Patients with lower urinary tract symptoms (LUTS)/ benign prostate hyperplasia (BPH) who were≧ 65 years old with refractory nocturia were enrolled in this study. We retrospectively analysed elderly men treated with adding desmopressin to current medications for nocturia according to category of the baseline nocturnal urine volume. The 48-h frequency volume chart (FVC), International Prostate Symptom Score (IPSS) and quality of life (QoL) were initially assessed and re-evaluated 12 weeks later. Serum sodium level was checked 1 week, 4 weeks, and 12 weeks after initiation of desmopressin therapy or suspected hyponatremia event. The mean change in numbers of nocturnal voids was evaluated for efficacy of treatment. A total of 136 patients were included with 55 in non-NP group and 81 in NP group. Hypertension was more common in NP group in regard of comorbidities. During treatment period, there were significant reductions of nocturnal voids from 4.22 ± 1.38 to 2.31 ± 0.98 (p < 0.001) in non-NP group and from 4.52 ± 1.23 to 2.07 ± 0.89 (p < 0.001) in NP group. The reduction in nocturnal voids was more significant in NP group (2.44 ± 1.15 vs. 1.91 ± 1.48, p = 0.003). The mean decrease in serum sodium levels were 3.89 ± 1.22 mmol/l (p < 0.001) in non-NP group and 4.69 ± 3.5 mmol/l (p < 0.001) in NP group at the extreme value. Long-term treatment with low-dose desmopressin is safe and effective for nocturia with or without NP in elderly patients with LUTS/BPH during real-life practice. Patients should be well informed about the disease and are closely followed. © 2016 John Wiley & Sons Ltd.

  5. Real-life effectiveness of spa therapy in rheumatic and musculoskeletal diseases: a retrospective study of 819 patients

    Science.gov (United States)

    Karagülle, Mine; Kardeş, Sinan; Karagülle, Müfit Zeki

    2017-11-01

    The objective of this study is to determine the use and efficacy of spa therapy in patients with a wide spectrum of rheumatic and musculoskeletal diseases under real-life clinical practice circumstances. In this retrospective observational study at the Medical Ecology and Hydroclimatology Department of Istanbul Faculty of Medicine, the records of all adult patients with rheumatic and musculoskeletal diseases who were prescribed a spa therapy in various health resorts in Turkey between 2002 and 2012 were analyzed. Patients sojourned to and stayed at a health resort and followed a usual 2-week course of spa therapy. The patients were examined within a week before and after the spa therapy at the department by the physicians and outcome measures were pain intensity (visual analog scale, VAS), patient's general evaluation (VAS), physician's general evaluation (VAS), Health Assessment Questionnaire (HAQ), Lequesne's Functional Index (LFI), Western Ontario and McMaster Universities Index (WOMAC), Waddell Index (WI), Neck Pain and Disability Scale (NPDS), Shoulder Disability Questionnaire (SDQ), Fibromyalgia Impact Questionnaire (FIQ), and Beck's Depression Inventory (BDI). In total, 819 patients were included in the analysis. The diagnoses were 536 osteoarthritis; 115 fibromyalgia; 50 lumbar disc herniation; 34 cervical disc herniation; 23 nonspecific low back pain; 22 ankylosing spondylitis; 16 rheumatoid arthritis; 9 rotator cuff tendinitis; and 14 other conditions/diseases including scoliosis, stenosing flexor tenosynovitis, congenital hip dislocation in adult, Behçet's disease, de Quervain tendinopathy, psoriatic arthritis, osteoporosis, fracture rehabilitation, and diffuse idiopathic skeletal hyperostosis. Statistically significant decrease in pain scores was found in all patients except hip osteoarthritis ( p = 0.063) and rheumatoid arthritis ( p = 0.134) subgroups; and statistically significant improvement in function in all patients except hip osteoarthritis ( p

  6. Story and Real Life

    Directory of Open Access Journals (Sweden)

    Robert P. Waxler

    2013-06-01

    Full Text Available Why should we be concerned about the fate of literature as we move from a book culture to a screen culture in the digital age? Not primarily because we are losing our sense of story, but because we are losing our sense of the central importance of linguistic narrative. There is a difference. The technologies creating the digital revolution seem to devalue language and increasingly to do away with boundaries, celebrating instead speed and boundless exhilaration. The visual trumps the linguistic, the image and the screen trump the word and the book. As a result, we no longer seem to engage deeply with others or ourselves. We are beginning to move, in other words, from “a reading brain” to “a digital brain,” from a brain capable of deep reading and deep thinking to a brain increasingly addled by spectacle and surface sensation. We are losing our standing as “linguistic beings.”

  7. Learning motivational interviewing in a real-life setting: a randomised controlled trial in the Swedish Prison Service.

    Science.gov (United States)

    Forsberg, Lars; Ernst, Denise; Farbring, Carl Åke

    2011-07-01

    Motivational interviewing (MI) is a client-centred, directive counselling style for helping people to explore and resolve ambivalence about behaviour change and shown to decrease drug and alcohol use. A five-session semi-structured MI intervention [Beteende, Samtal, Förändring (BSF; Behaviour, Counselling, Change)] was implemented in Swedish prisons. To examine whether, in a real-life implementation of semi-structured MI, staff receiving ongoing MI training, based on audio-recorded feedback in peer groups (BSF+), possess greater MI skill compared with staff receiving workshop-only MI training (BSF), and staff conducting usual prison planning interviews (UPI). Prisoners were randomised to one of the three interventions. The fi rst sessions between staff and prisoner with complete data were assessed with the Motivational Interviewing Treatment Integrity Code 3.0. Content analysis of 45 staff: prisoner sessions revealed that counsellors in the BSF+ group were significantly more competent in MI than those in the UPI group, but there was no difference in MI competency between the BSF and UPI groups. Overall, staff were rated as not having achieved beginning proficiency. Our findings suggest that staff delivering motivational interviewing programmes for substance-misusing prisoners in Sweden are not being given sufficient training for the task. Previous literature has suggested that staff need more than a basic 3- to 5-day workshop training, but our findings suggest that they may need longer-term continuing supervision and support than previously recognised.

  8. Occupation embedded in a real life: interweaving occupational science and occupational therapy. 1993 Eleanor Clarke Slagle Lecture.

    Science.gov (United States)

    Clark, F

    1993-12-01

    This lecture presents an example of research in the genre of interpretive occupational science and demonstrates how occupational science can inform clinical practice. The innovative qualitative methodology used blended elements of the anthropological tradition of life history ethnography, ethnomethodology, the naturalistic methods used by Mattingly and Schön to study practice, and especially narrative analysis as described by Polkinghorne. The bulk of the paper is presented in the form of a narrative analysis that provides an account of a stroke survivor's personal struggle for recovery, a story that emerged from transcription, coding, and analysis of transcripts from approximately 20 hours of interview time. First, this narrative analysis provides an example of how the occupational science framework can evoke a particular kind of storytelling in which childhood occupation can be related to adult character. Storytelling of this kind is later shown to be therapeutic for the stroke survivor. Next, the narrative illustrates how rehabilitation can be experienced by the survivor as a rite of passage in which a person is moved to disability status and then abandoned. Finally, a picture is given of how occupational story making and occupational storytelling embedded in real life can nurture the human spirit to act and can become the core of clinical practice.

  9. Power requirements and environmental impact of a pedelec. A case study based on real-life applications

    Energy Technology Data Exchange (ETDEWEB)

    Abagnale, Carmelina, E-mail: c.abagnale@unina.it; Cardone, Massimo, E-mail: massimo.cardone@unina.it; Iodice, Paolo, E-mail: paolo.iodice@unina.it; Strano, Salvatore, E-mail: salvatore.strano@unina.it; Terzo, Mario, E-mail: m.terzo@unina.it; Vorraro, Giovanni, E-mail: giovanni.vorraro@unina.it

    2015-07-15

    This paper describes the methodologies to appraise the power requests and environmental analysis of an electrically assisted bicycle under real driving conditions, also containing regulations and technical-science-related aspects. For this purpose, in this study, the on-road test program of an electrically assisted bicycle was executed in the urban area of Naples on different test tracks, so a general assessment about its driving behavior under several driving conditions was performed. The power requirements in different typical riding situations were estimated by a procedure based on the experimental kinematic parameters that characterize the driving dynamics collected during the real-life applications. An environmental analysis was also performed, with a methodology that takes into account the environmental assessment of a moped by measuring the experimental moped exhaust emissions of the regulated pollutants. Starting from the results acquired during the different test samples, besides, an assessment of the electric traction offered by this pedelec on the driving comfort was evaluated for different riding situations. - Highlights: • The power requirements of a pedelec in typical riding conditions were identified. • The estimated electricity consumption for battery recharging was defined. • An environmental valuation of the tested pedelec and of a moped was performed. • Emissions that could be saved utilizing a pedelec instead of a moped were derived.

  10. How real-life health messages engage our brains: Shared processing of effective anti-alcohol videos.

    Science.gov (United States)

    Imhof, Martin A; Schmälzle, Ralf; Renner, Britta; Schupp, Harald T

    2017-07-01

    Health communication via mass media is an important strategy when targeting risky drinking, but many questions remain about how health messages are processed and how they unfold their effects within receivers. Here we examine how the brains of young adults-a key target group for alcohol prevention-'tune in' to real-life health prevention messages about risky alcohol use. In a first study, a large sample of authentic public service announcements (PSAs) targeting the risks of alcohol was characterized using established measures of message effectiveness. In the main study, we used inter-subject correlation analysis of fMRI data to examine brain responses to more and less effective PSAs in a sample of young adults. We find that more effective messages command more similar responses within widespread brain regions, including the dorsomedial prefrontal cortex, insulae and precuneus. In previous research, these regions have been related to processing narratives, emotional stimuli, self-relevance and attention towards salient stimuli. The present study thus suggests that more effective health prevention messages have greater 'neural reach', i.e. they engage the brains of audience members' more widely. This work outlines a promising strategy for assessing the effects of health communication at a neural level. © The Author (2017). Published by Oxford University Press.

  11. Comparison between particulate matter and ultrafine particle emission by electronic and normal cigarettes in real-life conditions.

    Science.gov (United States)

    Ruprecht, Ario Alberto; De Marco, Cinzia; Pozzi, Paolo; Munarini, Elena; Mazza, Roberto; Angellotti, Giorgia; Turla, Francesca; Boffi, Roberto

    2014-01-01

    Electronic cigarettes may be safer than conventional cigarettes as they generate less indoor pollution in terms of particulate matter (PM); however, recent findings in experimental conditions demonstrated that secondhand exposure to PM may be expected from e-cigarette smoking. The aim of the present study was to investigate the emission of PM generated by e-cigarettes and normal cigarettes under real-life conditions. Real-time measurement and comparison of PM and ultrafine particles (UFP) generated by electronic cigarettes with and without nicotine and by normal cigarettes in a 50 m3 office of an Italian comprehensive cancer center was performed. PM mass as PM1, PM2.5, PM7, PM10, total suspended particles (TSP) in μg/m³ and UFP in number of particles per cubic centimeter from 10 to 1,000 nanometers were measured. Outdoor concentrations were measured contemporaneously to compensate for urban background changes. Regardless of their nicotine content, e-cigarettes generated lower PM levels than conventional cigarettes. Notably, nicotine-enriched e-cigarettes produced lower PM levels than their nicotine-free counterparts. E-cigarettes appear to generate less indoor pollution than normal cigarettes and may therefore be safer. Further studies are required to investigate the long-term health-related effects of secondhand e-cigarette exposure.

  12. VALIDITATION OF A LIGHT QUESTIONNAIRE WITH REAL-LIFE PHOTOPIC ILLUMINANCE MEASUREMENTS: THE HARVARD LIGHT EXPOSURE ASSESSMENT QUESTIONNAIRE

    Science.gov (United States)

    Bajaj, Archna; Rosner, Bernard; Lockley, Steven; Schernhammer, Eva S.

    2011-01-01

    Background Light exposure at night is now considered a probable carcinogen. To study the effects of light on chronic diseases like cancer, methods to measure light exposure in large observational studies are needed. We aimed to investigate the validity of self-reported current light exposure. Methods We developed a self-administered semiquantitative light questionnaire, the Harvard Light Exposure Assessment (H-LEA) questionnaire, and compared photopic scores derived from this questionnaire with actual photopic and circadian measures obtained from a real-life 7-day light meter application among 132 women (85 rotating night shift workers and 47 day workers) participating in the Nurses' Health Study II. Results After adjustment for age, BMI, collection day, and night work status, the overall partial Spearman correlation between self-report of light exposure and actual photopic light measurements was 0.72 (P<0.001; Kendall τ =0.57) and 0.73 (P<0.0001; Kendall τ =0.58) when correlating circadian light measurements. There were only minimal differences in accuracy of self-report of light exposure and photopic or circadian light measurement between day (r=0.77 and 0.78, respectively) and rotating night shift workers (r=0.68 and 0.69, respectively). Conclusions The results of this study provide evidence of the criterion validity of self-reported light exposure using the H-LEA questionnaire. Impact: This questionnaire is a practical method of assessing light exposure in large scale epidemiologic studies. PMID:21737411

  13. The Impact of Bottom-Up Parking Information Provision in a Real-Life Context: The Case of Antwerp

    Directory of Open Access Journals (Sweden)

    Geert Tasseron

    2017-01-01

    Full Text Available A number of studies have analyzed the possible impacts of bottom-up parking information or parking reservation systems on parking dynamics in abstract simulation environments. In this paper, we take these efforts one step further by investigating the impacts of these systems in a real-life context: the center of the city of Antwerp, Belgium. In our simulation, we assume that all on-street and off-street parking places are equipped with technology able to transmit their occupancy status to so-called smart cars, which can receive information and reserve a parking place. We employ PARKAGENT, an agent-based simulation model, to simulate the behavior of smart and regular cars. We obtain detailed data on parking demand from FEATHERS, an activity-based transport model. The simulation results show that parking information and reservation hardly impact search time but do reduce walking distance for smart cars, leading to a reduction in total parking time, that is, the sum of search time and walking time. Reductions in search time occur only in zones with high occupancy rates, while a drop in walking distance is especially observed in low occupancy areas. Societal benefits of parking information and reservation are limited, because of the low impact on search time and the possible negative health effects of reduced walking distance.

  14. Risk taking and adult attention deficit/hyperactivity disorder: A gap between real life behavior and experimental decision making.

    Science.gov (United States)

    Pollak, Yehuda; Shalit, Reut; Aran, Adi

    2018-01-01

    Adults with attention deficit/hyperactivity disorder (ADHD) are prone to suboptimal decision making and risk taking. The aim of this study was to test performance on a theoretically-based probabilistic decision making task in well-characterized adults with and without ADHD, and examine the relation between experimental risk taking and history of real-life risk-taking behavior, defined as cigarette, alcohol, and street drug use. University students with and without ADHD completed a modified version of the Cambridge Gambling Test, in which they had to choose between alternatives varied by level of risk, and reported their history of substance use. Both groups showed similar patterns of risk taking on the experimental decision making task, suggesting that ADHD is not linked to low sensitivity to risk. Past and present substance use was more prevalent in adults with ADHD. These finding question the validity of experimental probabilistic decision making task as a valid model for ADHD-related risk-taking behavior. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Dose uniformity of budesonide Easyhaler® under simulated real-life conditions and with low inspiration flow rates.

    Science.gov (United States)

    Haikarainen, Jussi; Rytilä, Paula; Roos, Sirkku; Metsärinne, Sirpa; Happonen, Anita

    2017-01-01

    Budesonide Easyhaler® multidose dry powder inhaler is approved for the treatment of asthma. Objectives were to determine the delivered dose (DD) uniformity of budesonide Easyhaler® in simulated real-world conditions and with different inspiration flow rates (IFRs). Three dose delivery studies were performed using 100, 200, and 400 µg/dose strengths of budesonide. Dose uniformity was assessed during in-use periods of 4-6 months after exposure to high temperature (30°C) and humidity (60% relative humidity) and after dropping and vibration testing. The influence of various IFRs (31, 43, and 54 L/min) on the DD was also investigated. Acceptable dose uniformity was declared when mean DD were within 80-120% of expected dose; all data reported descriptively. DD was constant (range: 93-109% of expected dose) at all in-use periods and after exposure to high temperature and humidity for a duration of up to 6 months. DD post-dropping and -vibration were unaffected (range 98-105% of expected dose). Similarly, DD was constant and within 10% of expected dose across all IFRs. Results indicate that budesonide Easyhaler® delivers consistently accurate doses in various real-life conditions. Budesonide Easyhaler® can be expected to consistently deliver a uniform dose and improve asthma control regardless of high temperature and humidity or varying IFR.

  16. Power requirements and environmental impact of a pedelec. A case study based on real-life applications

    International Nuclear Information System (INIS)

    Abagnale, Carmelina; Cardone, Massimo; Iodice, Paolo; Strano, Salvatore; Terzo, Mario; Vorraro, Giovanni

    2015-01-01

    This paper describes the methodologies to appraise the power requests and environmental analysis of an electrically assisted bicycle under real driving conditions, also containing regulations and technical-science-related aspects. For this purpose, in this study, the on-road test program of an electrically assisted bicycle was executed in the urban area of Naples on different test tracks, so a general assessment about its driving behavior under several driving conditions was performed. The power requirements in different typical riding situations were estimated by a procedure based on the experimental kinematic parameters that characterize the driving dynamics collected during the real-life applications. An environmental analysis was also performed, with a methodology that takes into account the environmental assessment of a moped by measuring the experimental moped exhaust emissions of the regulated pollutants. Starting from the results acquired during the different test samples, besides, an assessment of the electric traction offered by this pedelec on the driving comfort was evaluated for different riding situations. - Highlights: • The power requirements of a pedelec in typical riding conditions were identified. • The estimated electricity consumption for battery recharging was defined. • An environmental valuation of the tested pedelec and of a moped was performed. • Emissions that could be saved utilizing a pedelec instead of a moped were derived

  17. 'Real-life' study of imatinib therapy in chronic phase-chronic myeloid leukemia: A novel retrospective observational longitudinal analysis.

    Science.gov (United States)

    Merante, Serena; Ferretti, Virginia; Elena, Chiara; Calvello, Celeste; Rocca, Barbara; Zappatore, Rita; Cavigliano, Paola; Orlandi, Ester

    2017-01-01

    Imatinib is a cornerstone of treatment of chronic myeloid leukemia. It remains unclear whether transient treatment discontinuation or dose changes affect outcome and this approach has not yet been approved for use outside clinical trials. We conducted a retrospective single-institution observational study to evaluate factors affecting response in 'real-life' clinical practice in 138 chronic myeloid leukemia patients in chronic phase treated with imatinib. We used a novel longitudinal data analytical model, with a generalized estimating equation model, to study BCR-ABL variation according to continuous standard dose, change in dose or discontinuation; BCR-ABL transcript levels were recorded. Treatment history was subdivided into time periods for which treatment was given at constant dosage (total 483 time periods). Molecular and cytogenetic complete response was observed after 154 (32%) and 358 (74%) time periods, respectively. After adjusting for length of time period, no association between dose and cytogenetic complete response rate was observed. There was a significantly lower molecular complete response rate after time periods at a high imatinib dosage. This statistical approach can identify individual patient variation in longitudinal data collected over time and suggests that changes in dose or discontinuation of therapy could be considered in patients with appropriate biological characteristics.

  18. [Use of rivaroxaban in real-life treatment of venous thromboembolism: results of the TEV Survey, an Italian epidemiological study].

    Science.gov (United States)

    Pesavento, Raffaele; Iori, Ido

    2017-03-01

    Rivaroxaban is a direct and selective inhibitor of factor Xa. The randomized clinical trials EINSTEIN evaluated the efficacy and safety of rivaroxaban for the treatment of venous thromboembolism (VTE) proving that the drug was non-inferior to standard treatment. The aim of this survey was to describe how rivaroxaban was used in a group of "real-life" patients with VTE. Between June and October 2014, physicians collected aggregate data, through an online questionnaire, on consecutive patients affected by VTE and treated with rivaroxaban in the previous 6 months. Descriptive statistics were performed on the collected data. A total of 345 questionnaires were filled out. The mean age of patients was 62 years, with a low prevalence of concomitant diseases and/or pharmacological treatments. Deep vein thrombosis was diagnosed in 90% of patients and pulmonary embolism in 47%; only 48% was hospitalized. Rivaroxaban was prescribed at the recommended doses and/or regimen in no more than 60% of cases. In 96% of patients, the initial therapeutic plan did not require changes. Adherence to the therapeutic plan and overall patient satisfaction with therapy were high. Rivaroxaban was found easy to use and was highly appreciated by patients.

  19. Is it time for studying real-life debiasing? Evaluation of the effectiveness of an analogical intervention technique

    Directory of Open Access Journals (Sweden)

    Balazs eAczel

    2015-08-01

    Full Text Available The aim of this study was to initiate the exploration of debiasing methods applicable in real-life settings for achieving lasting improvement in decision-making competence regarding multiple decision biases. Here, we tested the potentials of the analogical encoding method for decision debiasing. The advantage of this method is that it can foster the transfer from learning abstract principles to improving behavioral performance. For the purpose of the study, we devised an analogical debiasing technique for ten biases (covariation detection, insensitivity to sample size, base rate neglect, regression to the mean, outcome bias, sunk cost fallacy, framing effect, anchoring bias, overconfidence bias, planning fallacy and assessed the susceptibility of the participants (N = 154 to these biases before and four weeks after the training. We also compared the effect of the analogical training to the effect of an ‘awareness training’ and a ‘no-training’ control group. Results suggested improved performance of the analogical training group only on tasks where the violations of statistical principles are measured. The interpretation of these findings require further investigation, yet it is possible that analogical training may be the most effective in the case of learning abstract concepts, such as statistical principles, which are otherwise difficult to master. The study encourages a systematic research of debiasing trainings and the development of intervention assessment methods to measure the endurance of behavior change in decision debiasing.

  20. Evaluation of Virological Microparticle Enzyme Immunoassay According to the ISO 15189: Real-Life Experience in a University Hospital.

    Science.gov (United States)

    Lafontaine, Sophie; Prin-Mathieu, Christine; Velay, Aurélie; Agulles, Odette; Schvoerer, Evelyne; Jeulin, Hélène

    2016-01-01

    The International Standard ISO 15189 based on the ISO 9001:2008 emphasizes specific requirements for quality and ability of medical laboratories. The accreditation of medical laboratories according to ISO 15189 includes the validation of biological methods, which depends on collection of bibliographic data and experimental proofs. Moreover, these results must be compared to provider data sheets and independent scientific data. In the immunodiagnostic field, independent published data are deeply lacking. The aim of our work was to share experience of method validation for virological immune markers on the widely used Architect i2000sr. After risk analysis, intra- and inter-assay variability, and inter-sample contamination were evaluated for each method, and sensitivity was investigated for antigen detection tests. A comparison between the two Architect i2000sr available in our laboratory was also performed. All tested methods were consistent with the manufacturer data (from the data sheet). No inter-sample contamination was observed. Both devices are broadly equivalent and can be used indifferently or as a backup solution of the other. To our knowledge, those results are the first independent complete data on the reliability of the Architect i2000sr in real-life experience. These data are needed to the accreditation of our platform and potentially useful for the accreditation of other laboratories using the same equipment.

  1. Son, you’re smoking on Facebook! College students’ disclosures on social networking sites as indicators of real-life risk behaviors

    NARCIS (Netherlands)

    van Hoof, Joris Jasper; Bekkers, Jeroen; van Vuuren, Hubrecht A.

    2014-01-01

    Health risk behavior in student populations is an issue of major concern, and students’ risk levels are difficult to determine. In this study, we explore the extent to which information disclosed publicly on Facebook provides reliable indications of five real-life health behaviors. Questionnaire

  2. Can You Tell Me Something about Yourself?: Self-Presentation in Children and Adolescents with High Functioning Autism Spectrum Disorder in Hypothetical and Real Life Situations

    Science.gov (United States)

    Scheeren, Anke M.; Begeer, Sander; Banerjee, Robin; Terwogt, Mark Meerum; Koot, Hans M.

    2010-01-01

    The self-presentation skills of children and adolescents with high-functioning autistic spectrum disorder (HFASD) and typically developing (TD) controls were compared, in response to both hypothetical and real life situations. In both situations, 26 HFASD and 26 TD participants were prompted to describe themselves twice, first in a baseline…

  3. Can virtual reality exposure therapy gains be generalized to real-life? A meta-analysis of studies applying behavioral assessments.

    Science.gov (United States)

    Morina, Nexhmedin; Ijntema, Hiske; Meyerbröker, Katharina; Emmelkamp, Paul M G

    2015-11-01

    In virtual reality exposure therapy (VRET), patients are exposed to virtual environments that resemble feared real-life situations. The aim of the current study was to assess the extent to which VRET gains can be observed in real-life situations. We conducted a meta-analysis of clinical trials applying VRET to specific phobias and measuring treatment outcome by means of behavioral laboratory tests or recordings of behavioral activities in real-life. Data sources were searches of databases (Medline, PsycInfo, and Cochrane). We included in total 14 clinical trials on specific phobias. Results revealed that patients undergoing VRET did significantly better on behavioral assessments following treatment than before treatment, with an aggregated uncontrolled effect size of g = 1.23. Furthermore, patients undergoing VRET performed better on behavioral assessments at post-treatment than patients on wait-list (g = 1.41). Additionally, results of behavioral assessment at post-treatment and at follow-up revealed no significant differences between VRET and exposure in vivo (g = -0.09 and 0.53, respectively). Finally, behavioral measurement effect sizes were similar to those calculated from self-report measures. The findings demonstrate that VRET can produce significant behavior change in real-life situations and support its application in treating specific phobias. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Off the fence, onto the bandwagon? A large-scale survey experiment on effect of real-life poll outcomes on subsequent vote intentions

    NARCIS (Netherlands)

    van der Meer, T.W.G.; Hakhverdian, A.; Aaldering, L.

    2016-01-01

    Despite decades of scholarly inquiry, the debate on the existence of a bandwagon effect in politics remains undecided. This article aims to overcome the limitations of previous experimental and survey research. We test to what extent success in real-life polling outcomes of the previous weeks

  5. Do Children Do What They Say? Responses to Hypothetical and Real-Life Social Problems in Children with Mild Intellectual Disabilities and Behaviour Problems

    Science.gov (United States)

    van Nieuwenhuijzen, M.; Bijman, E. R.; Lamberix, I. C. W.; Wijnroks, L.; de Castro, B. Orobio; Vermeer, A.; Matthys, W.

    2005-01-01

    Abstract: Background Most research on children's social problem-solving skills is based on responses to hypothetical vignettes. Just how these responses relate to actual behaviour in real-life social situations is, however, unclear, particularly for children with mild intellectual disabilities (MID). Method: In the present study, the spontaneous…

  6. Do children do what they say? Responses to hypothetical and real-life social problems in children with mild intellectual disabilities and behaviour problems

    NARCIS (Netherlands)

    van Nieuwenhuijzen, M; Bijman, ER; Lamberix, ICW; Wijnroks, L; de Castro, BO; Vermeer, A; Matthys, W

    Background Most research on children's social problem-solving skills is based on responses to hypothetical vignettes. Just how these responses relate to actual behaviour in real-life social situations is, however, unclear, particularly for children with mild intellectual disabilities (MID). Method

  7. The Cost of Your Shirt. A Simulation Exercise for Secondary Students and Adults, Based on the Real-Life Drama of Guatemalan Textile Workers.

    Science.gov (United States)

    Swenson, Mary, Comp.; Austin, Jane, Comp.

    This simulation exercise requires participants to practice critical thinking, problem solving, and negotiating skills as they role play real-life conflicts concerning working conditions in a factory in Guatemala City, Guatemala. Participants also learn about Guatemala's history, its social, economic, and political status as of April 1994. Based on…

  8. OCL-BASED TEST CASE GENERATION USING CATEGORY PARTITIONING METHOD

    Directory of Open Access Journals (Sweden)

    A. Jalila

    2015-10-01

    Full Text Available The adoption of fault detection techniques during initial stages of software development life cycle urges to improve reliability of a software product. Specification-based testing is one of the major criterions to detect faults in the requirement specification or design of a software system. However, due to the non-availability of implementation details, test case generation from formal specifications become a challenging task. As a novel approach, the proposed work presents a methodology to generate test cases from OCL (Object constraint Language formal specification using Category Partitioning Method (CPM. The experiment results indicate that the proposed methodology is more effective in revealing specification based faults. Furthermore, it has been observed that OCL and CPM form an excellent combination for performing functional testing at the earliest to improve software quality with reduced cost.

  9. Does Playing Sports Video Games Predict Increased Involvement in Real-Life Sports Over Several Years Among Older Adolescents and Emerging Adults?

    Science.gov (United States)

    Adachi, Paul J C; Willoughby, Teena

    2016-02-01

    Given the extreme popularity of video games among older adolescents and emerging adults, the investigation of positive outcomes of video game play during these developmental periods is crucial. An important direction for research in this area is the investigation of a link between sports video game play and involvement in real-life sports among youth. Yet, this association has not been examined in the long-term among older adolescents and emerging adults, and thus represents an exciting new area for discovery. The primary goal of the current study, therefore, was to examine the long-term association between sports video game play and involvement in real-life sports clubs among older adolescents and emerging adults. In addition, we examined whether self-esteem was an underlying mechanism of this longitudinal association. We surveyed older adolescents and emerging adults (N = 1132; 70.6 % female; M age = 19.06 years, range of 17-25 years at the first assessment) annually over 3 years about their video game play, self-esteem, and involvement in real-life sports. We found a long-term predictive effect of sports video game play on increased involvement in real-life sports over the 3 years. Furthermore, we demonstrated that self-esteem was an underlying mechanism of this long-term association. Our findings make an important contribution to an emerging body of literature on the positive outcomes of video game play, as they suggest that sports video game play may be an effective tool to promote real-life sports participation and physical activity among older adolescents and emerging adults.

  10. DWPF PCCS version 2.0 test case

    International Nuclear Information System (INIS)

    Brown, K.G.; Pickett, M.A.

    1992-01-01

    To verify the operation of the Product Composition Control System (PCCS), a test case specific to DWPF operation was developed. The values and parameters necessary to demonstrate proper DWPF product composition control have been determined and are presented in this paper. If this control information (i.e., for transfers and analyses) is entered into the PCCS as illustrated in this paper, and the results obtained correspond to the independently-generated results, it can safely be said that the PCCS is operating correctly and can thus be used to control the DWPF. The independent results for this test case will be generated and enumerated in a future report. This test case was constructed along the lines of the normal DWPF operation. Many essential parameters are internal to the PCCS (e.g., property constraint and variance information) and can only be manipulated by personnel knowledgeable of the Symbolics reg-sign hardware and software. The validity of these parameters will rely on induction from observed PCCS results. Key process control values are entered into the PCCS as they would during normal operation. Examples of the screens used to input specific process control information are provided. These inputs should be entered into the PCCS database, and the results generated should be checked against the independent, computed results to confirm the validity of the PCCS

  11. A Human Proximity Operations System test case validation approach

    Science.gov (United States)

    Huber, Justin; Straub, Jeremy

    A Human Proximity Operations System (HPOS) poses numerous risks in a real world environment. These risks range from mundane tasks such as avoiding walls and fixed obstacles to the critical need to keep people and processes safe in the context of the HPOS's situation-specific decision making. Validating the performance of an HPOS, which must operate in a real-world environment, is an ill posed problem due to the complexity that is introduced by erratic (non-computer) actors. In order to prove the HPOS's usefulness, test cases must be generated to simulate possible actions of these actors, so the HPOS can be shown to be able perform safely in environments where it will be operated. The HPOS must demonstrate its ability to be as safe as a human, across a wide range of foreseeable circumstances. This paper evaluates the use of test cases to validate HPOS performance and utility. It considers an HPOS's safe performance in the context of a common human activity, moving through a crowded corridor, and extrapolates (based on this) to the suitability of using test cases for AI validation in other areas of prospective application.

  12. Prioritizing Test Cases for Memory Leaks in Android Applications

    Institute of Scientific and Technical Information of China (English)

    Ju Qian; Di Zhou

    2016-01-01

    Mobile applications usually can only access limited amount of memory. Improper use of the memory can cause memory leaks, which may lead to performance slowdowns or even cause applications to be unexpectedly killed. Although a large body of research has been devoted into the memory leak diagnosing techniques after leaks have been discovered, it is still challenging to find out the memory leak phenomena at first. Testing is the most widely used technique for failure discovery. However, traditional testing techniques are not directed for the discovery of memory leaks. They may spend lots of time on testing unlikely leaking executions and therefore can be inefficient. To address the problem, we propose a novel approach to prioritize test cases according to their likelihood to cause memory leaks in a given test suite. It firstly builds a prediction model to determine whether each test can potentially lead to memory leaks based on machine learning on selected code features. Then, for each input test case, we partly run it to get its code features and predict its likelihood to cause leaks. The most suspicious test cases will be suggested to run at first in order to reveal memory leak faults as soon as possible. Experimental evaluation on several Android applications shows that our approach is effective.

  13. Using CASE-tools based on formal methods in real-life system development of distributed systems

    International Nuclear Information System (INIS)

    Stoelen, Ketil; Karlsen, Tore Willy; Mohn, Peter; Sandmark, Haaakon

    1998-03-01

    Within the OECD Halden Reactor Project (HRP) the development and application of formal methods to enhance system quality have been prioritised tasks for the last three years per periods. The three year programme 1997-1999 identifies the need to gain experience from applying formal methods in larger real-life system developments. This motivated the initiation of the HRP research activity Integration of Formal Specification in the Development of HAMMLAB 2000 (INT-FS). The principal objective of INT-FS is to experiment with formal methods in system developments connected to HAMMLAB 2000 and thereby gain a better understanding of their suitability to support practical software engineering. In particular, INT-FS will try to measure the effect of formal methods and gain experience in combining formal methods with traditional development techniques. INT-FS was started up in January 1997. This report describes the status of INT-FS by February 1998. The report identifies objectives and plans; it motivates the choice of formal methods, CASE-tool and software process; it motivates and defines metrics for measuring achievement and the effect of formalization. The report also provides preliminary results from an experimental development of a communication manager; it describes the component to be developed and the background of the participants; it offers some provisional statistics and summarises the experiences with methods and tools. The development of the communication manager is the first attempt ever to exploit state-of-the-art CASE-tools for formal methods in practical software engineering at the HRP. (author)

  14. Changes in albuminuria and renal outcome in patients with type 2 diabetes and hypertension: a real-life observational study.

    Science.gov (United States)

    Viazzi, Francesca; Ceriello, Antonio; Fioretto, Paola; Giorda, Carlo; Guida, Pietro; Russo, Giuseppina; Greco, Eulalia; De Cosmo, Salvatore; Pontremoli, Roberto

    2018-04-19

    To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimated glomerular filtration rate (eGFR) at baseline and regular visits during a 4-year period were retrieved and analyzed. We assessed the association between changes in albuminuria status during a 1-year baseline period and time updated blood pressure (BP) and eGFR loss over the subsequent 4-year follow-up. Mean age at baseline was 65 ± 9 years, known duration of diabetes11 ± 8 years, eGFR 85 ± 13 ml/min and BP 142 ± 17/81 ± 9 mmHg. Patients with persistent albuminuria showed the highest 4-year risk of eGFR loss more than 30% from baseline or onset of stage 3 chronic kidney disease (eGFR < 60 ml/min) as compared with those with persistent normal albuminuria (odds ratio 2.00, confidence interval 1.71-2.34; P < 0.001). Female sex, age, disease duration, BMI, low baseline eGFR, lipid profile, the number of antihypertensive drugs and variations in albuminuria status were associated with renal risk in the whole study population. Furthermore, lower time updated BP values and the use of renin-angiotensin-aldosterone-system-inhibitors were related to the occurrence of renal endpoints only in the subgroup of patients without albuminuria. In patients with hypertension and T2D under real-life clinical conditions, changes in albuminuria parallel changes of renal risk. Albuminuria status could be a guide to optimize therapeutic strategy.

  15. Differential influence of the 5-HTTLPR genotype, neuroticism and real-life acute stress exposure on appetite and energy intake.

    Science.gov (United States)

    Capello, Aimée E M; Markus, C Rob

    2014-06-01

    Stress or negative mood often promotes energy intake and overeating. Since the serotonin transporter-linked polymorphic region (5-HTTLPR) is found to mediate stress vulnerability as well as to influence energy intake, this gene may also influence the negative effects of stress exposure on overeating. Moreover, since stress proneness also reflects cognitive stress vulnerability - as often defined by trait neuroticism - this may additionally predispose for stress-induced overeating. In the present study it was investigated whether the 5-HTTLPR genotype interacted with neuroticism on changes in mood, appetite and energy intake following exposure to a real-life academic examination stressor. In a balanced-experimental design, homozygous S-allele and L-allele carriers (N = 94) with the lowest and highest neuroticism scores were selected from a large database of 5-HTTLPR genotyped students. Mood, appetite and energy intake were measured before and after a 2-hour academic examination and compared with a control day. Examination influenced appetite for particular sweet snacks differently depending on 5-HTTLPR genotype and neuroticism. S/S compared with L/L subjects reported greater examination stress, and this was accompanied by a more profound post-stress increase in appetite for sweet snacks. Data also revealed a 5-HTTLPR genotype by trait neuroticism interaction on energy intake, regardless of examination. These results consolidate previous assumptions of 5-HTTLPR involvement in stress vulnerability and suggest 5-HTTLPR and neuroticism may influence stress-induced overeating depending on the type of food available. These findings furthermore link previous findings of increased risk for weight gain in S/S-allele carriers, particularly with high scores on trait neuroticism, to increased energy intake. Copyright © 2014 Elsevier Ltd. All rights reserved.

  16. CorVue algorithm efficacy to predict heart failure in real life: Unnecessary and potentially misleading information?

    Science.gov (United States)

    Palfy, Julia Anna; Benezet-Mazuecos, Juan; Milla, Juan Martinez; Iglesias, Jose Antonio; de la Vieja, Juan Jose; Sanchez-Borque, Pepa; Miracle, Angel; Rubio, Jose Manuel

    2018-06-01

    Heart failure (HF) hospitalizations have a negative impact on quality of life and imply important costs. Intrathoracic impedance (ITI) variations detected by cardiac devices have been hypothesized to predict HF hospitalizations. Although Optivol™ algorithm (Medtronic) has been widely studied, CorVue™ algorithm (St. Jude Medical) long term efficacy has not been systematically evaluated in a "real life" cohort. CorVue™ was activated in ICD/CRT-D patients to store information about ITI measures. Clinical events (new episodes of HF requiring treatment and hospitalizations) and CorVue™ data were recorded every three months. Appropriate CorVue™ detection for HF was considered if it occurred in the four prior weeks to the clinical event. 53 ICD/CRT-D (26 ICD and 27 CRT-D) patients (67±1 years-old, 79% male) were included. Device position was subcutaneous in 28 patients. At inclusion, mean LVEF was 25±7% and 27 patients (51%) were in NYHA class I, 18 (34%) class II and 8 (15%) class III. After a mean follow-up of 17±9 months, 105 ITI drops alarms were detected in 32 patients (60%). Only six alarms were appropriate (true positive) and required hospitalization. Eighteen patients (34%) presented 25 clinical episodes (12 hospitalizations and 13 ER/ambulatory treatment modifications). Nineteen of these clinical episodes (76%) remained undetected by the CorVue™ (false negative). Sensitivity of CorVue™ resulted in 24%, specificity was 70%, positive predictive value of 6% and negative predictive value of 93%. CorVue™ showed a low sensitivity to predict HF events. Therefore, routinely activation of this algorithm could generate misleading information. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  17. An Anomalous Noise Events Detector for Dynamic Road Traffic Noise Mapping in Real-Life Urban and Suburban Environments

    Directory of Open Access Journals (Sweden)

    Joan Claudi Socoró

    2017-10-01

    Full Text Available One of the main aspects affecting the quality of life of people living in urban and suburban areas is their continued exposure to high Road Traffic Noise (RTN levels. Until now, noise measurements in cities have been performed by professionals, recording data in certain locations to build a noise map afterwards. However, the deployment of Wireless Acoustic Sensor Networks (WASN has enabled automatic noise mapping in smart cities. In order to obtain a reliable picture of the RTN levels affecting citizens, Anomalous Noise Events (ANE unrelated to road traffic should be removed from the noise map computation. To this aim, this paper introduces an Anomalous Noise Event Detector (ANED designed to differentiate between RTN and ANE in real time within a predefined interval running on the distributed low-cost acoustic sensors of a WASN. The proposed ANED follows a two-class audio event detection and classification approach, instead of multi-class or one-class classification schemes, taking advantage of the collection of representative acoustic data in real-life environments. The experiments conducted within the DYNAMAP project, implemented on ARM-based acoustic sensors, show the feasibility of the proposal both in terms of computational cost and classification performance using standard Mel cepstral coefficients and Gaussian Mixture Models (GMM. The two-class GMM core classifier relatively improves the baseline universal GMM one-class classifier F1 measure by 18.7% and 31.8% for suburban and urban environments, respectively, within the 1-s integration interval. Nevertheless, according to the results, the classification performance of the current ANED implementation still has room for improvement.

  18. [Pathway to diagnosis and real-life experience of patients believing they are affected by "chronic Lyme disease"].

    Science.gov (United States)

    Forestier, E; Gonnet, F; Revil-Signorat, A; Zipper, A C

    2018-04-26

    Chronic Lyme disease is a subject of scientific and social controversy in both Europe and the United States. The aim of our study was to analyze the pathway to diagnosis of patients believing they were affected by the disease, and to describe their real-life experience. A qualitative study was performed with 13 patients declaring themselves to be affected by chronic Lyme disease. Interviews were analyzed by 2 general medical practice interns, supervised by a general practitioner with a diploma in socio-anthropology and an infectious diseases specialist. Internet and other media played a major role in informing the patients or their doctor about the existence and the characteristics of chronic Lyme disease. The diagnosis was confirmed by features considered objective (chronic infection by Borrelia, tick bite, positive serology, beneficial or worsening effects of antibiotics). The long medical diagnosis and treatment process of those interviewed was marked by a conflicted relationship with the medical profession, caused by a feeling of non-recognition and abandonment. They reported their experience as being very painful, both because of the physical pain and also the psychological consequences of their condition. Improving the diagnosis and therapeutic management of patients believing themselves to be affected by chronic Lyme disease appears highly necessary both to limit their search for diagnosis and their experience of pain. It could be based on existing guidelines concerning medically unexplained symptoms to which the chronic Lyme disease issue appears quite similar on several points. Copyright © 2018 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier SAS. All rights reserved.

  19. Treatment satisfaction of patients undergoing ranibizumab therapy for neovascular age-related macular degeneration in a real-life setting

    Directory of Open Access Journals (Sweden)

    Gohil R

    2016-05-01

    Full Text Available Rishma Gohil,1,2 Roxanne Crosby-Nwaobi,1,2 Angus Forbes,2 Ben J Burton,3 Philip Hykin,1 Sobha Sivaprasad1,4 1National Institute for Health Research Moorfields Biomedical Research Centre, London, 2Diabetes Nursing, King’s College London, London, 3Ophthalmology Department, James Paget University Hospital, Great Yarmouth, 4Laser and Retinal Research Unit, King’s College Hospital, London, UK Context: Treatment satisfaction with a loading phase of monthly injections for 3 months followed by a pro-re-nata regimen of ranibizumab in neovascular age-related macular degeneration (nAMD remains unclear.Aims: The aim was to evaluate the treatment satisfaction of persons with nAMD treated with ranibizumab in a real-life setting.Settings and design: A cross-sectional study was conducted across three eye clinics within the National Health Service in the UK, where treatment is provided free at point of contact.Materials and methods: A total of 250 patients were selected randomly for the study. Treatment satisfaction was assessed using the Macular Treatment Satisfaction Questionnaire. Data were collected on satisfaction of the service provided (Client Service Questionnaire-8 and the patients’ demographic and quality of life and treatment history. Factors governing treatment questionnaire were determined.Results: The most important factors that determined the satisfaction were the service provided at the clinic (Client Service Questionnaire-8, health-related quality of life (EQ-5D-3L, and duration of AMD. Visual acuity changes were rated as less important than one would have expected.Conclusion: The study result suggested that treatment satisfaction for nAMD was governed by the perception of being reviewed and injected regularly over a long period of time than the actual change in visual acuity from the treatment. Keyword: macular treatment satisfaction questionnaire, patient related outcome measure, treatment history, quality of life 

  20. Acute social stress before the planning phase improves memory performance in a complex real life-related prospective memory task.

    Science.gov (United States)

    Glienke, Katharina; Piefke, Martina

    2016-09-01

    Successful execution of intentions, but also the failure to recall are common phenomena in everyday life. The planning, retention, and realization of intentions are often framed as the scientific concept of prospective memory. The current study aimed to examine the influence of acute stress on key dimensions of complex "real life" prospective memory. To this end, we applied a prospective memory task that involved the planning, retention, and performance of intentions during a fictional holiday week. Forty healthy males participated in the study. Half of the subjects were stressed with the Socially Evaluated Cold Pressor Test (SECPT) before the planning of intentions, and the other half of the participants underwent a control procedure at the same time. Salivary cortisol was used to measure the effectiveness of the SECPT stress induction. Stressed participants did not differ from controls in planning accuracy. However, when we compared stressed participants with controls during prospective memory retrieval, we found statistically significant differences in PM across the performance phase. Participants treated with the SECPT procedure before the planning phase showed improved prospective memory retrieval over time, while performance of controls declined. Particularly, there was a significant difference between the stress and control group for the last two days of the holiday week. Interestingly, control participants showed significantly better performance for early than later learned items, which could be an indicator of a primacy effect. This differential effect of stress on performance was also found in time- and event-dependent prospective memory. Our results demonstrate for the first time, that acute stress induced before the planning phase may improve prospective memory over the time course of the performance phase in time- and event-dependent prospective memory. Our data thus indicate that prospective memory can be enhanced by acute stress. Copyright © 2016

  1. eFAST for Pneumothorax: Real-Life Application in an Urban Level 1 Center by Trauma Team Members.

    Science.gov (United States)

    Maximus, Steven; Figueroa, Cesar; Whealon, Matthew; Pham, Jacqueline; Kuncir, Eric; Barrios, Cristobal

    2018-02-01

    The focused assessment with sonography for trauma (FAST) examination has become the standard of care for rapid evaluation of trauma patients. Extended FAST (eFAST) is the use of ultrasonography for the detection of pneumothorax (PTX). The exact sensitivity and specificity of eFAST detecting traumatic PTX during practical "real-life" application is yet to be investigated. This is a retrospective review of all trauma patients with a diagnosis of PTX, who were treated at a large level 1 urban trauma center from March 2013 through July 2014. Charts were reviewed for results of imaging, which included eFAST, chest X-ray, and CT scan. The requirement of tube thoracostomy and mechanism of injury were also analyzed. A total of 369 patients with a diagnosis of PTX were identified. A total of 69 patients were excluded, as eFAST was either not performed or not documented, leaving 300 patients identified with PTX. A total of 113 patients had clinically significant PTX (37.6%), requiring immediate tube thoracostomy placement. eFAST yielded a positive diagnosis of PTX in 19 patients (16.8%), and all were clinically significant, requiring tube thoracostomy. Chest X-ray detected clinically significant PTX in 105 patients (92.9%). The literature on the utility of eFAST for PTX in trauma is variable. Our data show that although specific for clinically significant traumatic PTX, it has poor sensitivity when performed by clinicians with variable levels of ultrasound training. We conclude that CT is still the gold standard in detecting PTX, and clinicians performing eFAST should have adequate training.

  2. Quality of life improvement in HIV-1 patients treated with raltegravir in a real-life observational study: RACING.

    Science.gov (United States)

    Spire, Bruno; Nait-Ighil, Lella; Pugliese, Pascal; Poizot-Martin, Isabelle; Jullien, Vincent; Marcelin, Anne-Geneviève; Billaud, Eric

    2017-01-01

    Good efficacy and safety of raltegravir in person living with HIV was demonstrated in clinical trials over five years, but real-life data, particularly about quality of life (QoL), are lacking. QoL was evaluated over time in adult patients first treated or switched to regimens containing raltegravir in an observational cohort study. Patient QoL was evaluated using the Fatigue Impact Scale (FIS) and the HIV Symptom Index (HSI). Data were collected at baseline and at 1, 3, 6, 12, 18, and 24 months. Baseline FIS and HSI subscores were compared with the scores at each visit using the paired Wilcoxon test. The impact of time, sociodemographic and medical variables upon patient-perceived fatigue and symptoms was also assessed using mixed multivariate models. From baseline, all FIS and HSI subscores improved significantly after one month of treatment. In addition, psychosocial FIS subscores and both the frequency of bothersome symptoms and HSI subscores improved significantly at each visit. Physical FIS subscores also improved significantly, except at month 18, whereas both cognitive and total FIS subscores improved only after 6 months and 24 months, respectively. In multivariate analysis, employment was independently associated over time with improved improvement in both FIS and HSI subscores. Patient QoL improved significantly over a 24-month period of treatment with a raltegravir-containing regimen. FIS and HSI are sensitive tools to measure the impact of new antiretroviral combinations on a patient's perception of QoL.

  3. Relational Constraint Driven Test Case Synthesis for Web Applications

    Directory of Open Access Journals (Sweden)

    Xiang Fu

    2010-09-01

    Full Text Available This paper proposes a relational constraint driven technique that synthesizes test cases automatically for web applications. Using a static analysis, servlets can be modeled as relational transducers, which manipulate backend databases. We present a synthesis algorithm that generates a sequence of HTTP requests for simulating a user session. The algorithm relies on backward symbolic image computation for reaching a certain database state, given a code coverage objective. With a slight adaptation, the technique can be used for discovering workflow attacks on web applications.

  4. Large block migration experiments: INTRAVAL phase 1, Test Case 9

    Energy Technology Data Exchange (ETDEWEB)

    Gureghian, A.B.; Noronha, C.J. (Battelle, Willowbrook, IL (USA). Office of Waste Technology Development); Vandergraaf, T.T. (Atomic Energy of Canada Ltd., Ottawa, ON (Canada))

    1990-08-01

    The development of INTRAVAL Test Case 9, as presented in this report, was made possible by a past subsidiary agreement to the bilateral cooperative agreement between the US Department of Energy (DOE) and Atomic Energy of Canada Limited (AECL) encompassing various aspects of nuclear waste disposal research. The experimental aspect of this test case, which included a series of laboratory experiments designed to quantify the migration of tracers in a single, natural fracture, was undertaken by AECL. The numerical simulation of the results of these experiments was performed by the Battelle Office of Waste Technology Development (OWTD) by calibrating an in-house analytical code, FRACFLO, which is capable of predicting radionuclide transport in an idealized fractured rock. Three tracer migration experiments were performed, using nonsorbing uranine dye for two of them and sorbing Cs-137 for the third. In addition, separate batch experiments were performed to determine the fracture surface and rock matrix sorption coefficients for Cs-137. The two uranine tracer migration experiment were used to calculate the average fracture aperture and to calibrate the model for the fracture dispersivity and matrix diffusion coefficient. The predictive capability of the model was then tested by simulating the third, Cs-137, tracer test without changing the parameter values determined from the other experiments. Breakthrough curves of both the experimental and numerical results obtained at the outlet face of the fracture are presented for each experiment. The reported spatial concentration profiles for the rock matrix are based solely on numerical predictions. 22 refs., 12 figs., 8 tabs.

  5. Temporal condensation and dynamic λ-transition within the complex network: an application to real-life market evolution

    Science.gov (United States)

    Wiliński, Mateusz; Szewczak, Bartłomiej; Gubiec, Tomasz; Kutner, Ryszard; Struzik, Zbigniew R.

    2015-02-01

    We fill a void in merging empirical and phenomenological characterisation of the dynamical phase transitions in complex networks by identifying and thoroughly characterising a triple sequence of such transitions on a real-life financial market. We extract and interpret the empirical, numerical, and analytical evidences for the existence of these dynamical phase transitions, by considering the medium size Frankfurt stock exchange (FSE), as a typical example of a financial market. By using the canonical object for the graph theory, i.e. the minimal spanning tree (MST) network, we observe: (i) the (initial) dynamical phase transition from equilibrium to non-equilibrium nucleation phase of the MST network, occurring at some critical time. Coalescence of edges on the FSE's transient leader (defined by its largest degree) is observed within the nucleation phase; (ii) subsequent acceleration of the process of nucleation and the emergence of the condensation phase (the second dynamical phase transition), forming a logarithmically diverging temporal λ-peak of the leader's degree at the second critical time; (iii) the third dynamical fragmentation phase transition (after passing the second critical time), where the λ-peak logarithmically relaxes over three quarters of the year, resulting in a few loosely connected sub-graphs. This λ-peak (comparable to that of the specific heat vs. temperature forming during the equilibrium continuous phase transition from the normal fluid I 4He to the superfluid II 4He) is considered as a prominent result of a non-equilibrium superstar-like superhub or a dragon-king's abrupt evolution over about two and a half year of market evolution. We capture and meticulously characterise a remarkable phenomenon in which a peripheral company becomes progressively promoted to become the dragon-king strongly dominating the complex network over an exceptionally long period of time containing the crash. Detailed analysis of the complete trio of the

  6. Optimal screening mammography reading volumes; evidence from real life in the East Midlands region of the NHS Breast Screening Programme

    International Nuclear Information System (INIS)

    Cornford, E.; Reed, J.; Murphy, A.; Bennett, R.; Evans, A.

    2011-01-01

    Aim: To assess real-life reader performance as a function of both volume of mammograms read and reading experience in a multicentre cohort. Materials and methods: Thirty-seven film readers from the East Midlands Breast Screening Programme had 3 years of consecutive screen reading results available for comparison. Markers of screening performance as the first film reader [cancer detection rates, small cancer detection rates, recall rates, positive predictive value of recall (PPV), and missed cancers] were compared with both volume of films read and years of film reading experience. For reading volume, readers were categorized according to film reading volume over the 3 year period: <15,000 (i.e., on average less than the recommended 5000/year); 15-<20,000; 20-<25,000; and ≥25,000. For years of experience, readers were categorized into the following groups: <5 years, 5-<10 years, 10-<15 years, and 15-<20 years. Results: There was no evidence to suggest a relationship between years of film reading experience and film-reading performance. For reading volume, there was a significant difference in the distribution of cancer-detection rate between the four groups (p = 0.01); however, there was no difference in small cancer-detection rates, missed cancers or PPV. The median cancer detection rate in the high-volume group (≥25,000 mammograms/3 years) was significantly lower than the other groups combined (6.9 per 1000 women screened versus 7.9 per 1000 women screened). The lowest median recall rate was also in the high-volume group, whilst those readers not meeting the NHSBSP minimum requirement had the highest median recall rate; however, there was borderline evidence to suggest a difference in the distribution of recall rates between the four groups. Conclusion: The data from the East Midlands do not provide any evidence for reducing the threshold volume of 5000 cases /year. However, there appears to be an upper limit above which reader performance deteriorates in

  7. Real life safety benefits of increasing brake deceleration in car-to-pedestrian accidents: Simulation of Vacuum Emergency Braking.

    Science.gov (United States)

    Jeppsson, Hanna; Östling, Martin; Lubbe, Nils

    2018-02-01

    The objective of this study is to predict the real-life benefits, namely the number of injuries avoided rather than the reduction in impact speed, offered by a Vacuum Emergency Brake (VEB) added to a pedestrian automated emergency braking (AEB) system. We achieve this through the virtual simulation of simplified mathematical models of a system which incorporates expected future advances in technology, such as a wide sensor field of view, and reductions in the time needed for detection, classification, and brake pressure build up. The German In-Depth Accident Study database and the related Pre Crash Matrix, both released in the beginning of 2016, were used for this study and resulted in a final sample of 526 collisions between passenger car fronts and pedestrians. Weight factors were calculated for both simulation model and injury risk curves to make the data representative of Germany as a whole. The accident data was used with a hypothetical AEB system in a simulation model, and injury risk was calculated from the new impact speed using injury risk curves to generate new situations using real accidents. Adding a VEB to a car with pedestrian AEB decreased pedestrian casualties by an additional 8-22%, depending on system setting and injury level, over the AEB-only system. The overall decrease in fatalities was 80-87%, an improvement of 8%. Collision avoidance was improved by 14-28%. VEB with a maximum deceleration in the middle of the modelled performance range has an effectiveness similar to that of an "early activation" system, where the AEB is triggered as early as 2 s before collision. VEB may therefore offer a substantial increase in performance without increasing false positive rates, which earlier AEB activation does. Most collisions and injuries can be avoided when AEB is supplemented by the high performance VEB; remaining cases are characterised by high pedestrian walking speed and late visibility due to view obstructions. VEB is effective in all analysed

  8. Menu-engineering in restaurants - adapting portion sizes on plates to enhance vegetable consumption: a real-life experiment.

    Science.gov (United States)

    Reinders, Machiel J; Huitink, Marlijn; Dijkstra, S Coosje; Maaskant, Anna J; Heijnen, Joris

    2017-12-25

    The aim of this research was to investigate whether increased portion sizes of vegetables and decreased portion sizes of meat on main dishes increased the amount of vegetables consumed in a real-life restaurant setting without affecting customer satisfaction. The participants were unaware of the experiment. A cross-over design was used in which three restaurants were randomly assigned to a sequence of an intervention and control condition. In the intervention period, the vegetable portion sizes on the plates of main dishes were doubled (150 g of vegetables instead of 75 g) and the portion sizes of meat on the plates were reduced by an average of 12.5%. In the control period, the portion sizes of the main dishes were maintained as usual. In total, 1006 observations and questionnaires were included. Vegetable consumption from plates was significantly higher during the intervention period (M = 115.5 g) than during the control period (M = 61.7 g). Similarly, total vegetable consumption (including side dishes) was significantly higher during the intervention period (M = 178.0 g) than during the control period (M = 137.0 g). Conversely, meat consumption was significantly lower during the intervention period (M = 183.1 g) than during the control period (M = 211.1 g). Satisfaction with the restaurant visit did not differ between the intervention period (M = 1.27) and control period (M = 1.35). Satisfaction with the main dish was significantly lower during the intervention period (M = 1.25) than during the control period (M = 1.38), although in both cases, the scores indicated that participants remained (very) satisfied with their main dish. This study showed that increasing vegetable portions in combination with decreasing meat portions (unknowingly to the consumer) increased the amount of vegetables consumed and decreased the amount of meat consumed. Furthermore, despite the changes in portion sizes, participants remained satisfied

  9. Comparative quality measures of emergency care: an outcome cockpit proposal to survey clinical processes in real life

    Directory of Open Access Journals (Sweden)

    Burgemeister S

    2017-10-01

    Full Text Available Susanne Burgemeister,1 Alexander Kutz,1 Antoinette Conca,2 Thomas Holler,3 Sebastian Haubitz,1 Andreas Huber,4 Ulrich Buergi,5 Beat Mueller,1 Philipp Schuetz1 1University Department of Internal Medicine, Medical Faculty of the University of Basel, Kantonsspital Aarau, Basel, 2Department of Clinical Nursing Science, 3Department of Controlling and Quality Management, 4Department of Laboratory Medicine, 5Emergency Department, Kantonsspital Aarau, Aarau, Switzerland Background: Benchmarking of real-life quality of care may improve evaluation and comparability of emergency department (ED care. We investigated process management variables for important medical diagnoses in a large, well-defined cohort of ED patients and studied predictors for low quality of care. Methods: We prospectively included consecutive medical patients with main diagnoses of community-acquired pneumonia, urinary tract infection (UTI, myocardial infarction (MI, acute heart failure, deep vein thrombosis, and COPD exacerbation and followed them for 30 days. We studied predictors for alteration in ED care (treatment times, satisfaction with care, readmission rates, and mortality by using multivariate regression analyses.Results: Overall, 2986 patients (median age 72 years, 57% males were included. The median time to start treatment was 72 minutes (95% CI: 23 to 150, with a median length of ED stay (ED LOS of 256 minutes (95% CI: 166 to 351. We found delayed treatment times and longer ED LOS to be independently associated with main medical admission diagnosis and time of day on admission (shortest times for MI and longest times for UTI. Time to first physician contact (–0.01 hours, 95% CI: –0.03 to –0.02 and ED LOS (–0.01 hours, 95% CI: –0.02 to –0.04 were main predictors for patient satisfaction. Conclusion: Within this large cohort of consecutive patients seeking ED care, we found time of day on admission to be an important predictor for ED timeliness, which again

  10. Acute hepatitis C in persons infected with the human immunodeficiency virus (HIV: The "Real-life Setting" proves the concept

    Directory of Open Access Journals (Sweden)

    Obermeier M

    2011-05-01

    HIV infected patients affects mainly MSM who acquire HCV sexually. Patients had a short duration of HIV infection and a stable immunological situation. In this real-life setting from urban regions in northern Germany, treatment rates appear to be high and effective.

  11. Real-life indications to ivabradine treatment for heart rate optimization in patients with chronic systolic heart failure.

    Science.gov (United States)

    Tondi, Lara; Fragasso, Gabriele; Spoladore, Roberto; Pinto, Giuseppe; Gemma, Marco; Slavich, Massimo; Godino, Cosmo; Salerno, Anna; Montanaro, Claudia; Margonato, Alberto

    2018-05-11

    : Ivabradine is a selective and specific inhibitor of If current. With its pure negative chronotropic action, it is recommended by European Society of Cardiology and American College of Cardiology/American Heart Association guidelines in symptomatic heart failure patients (NYHA ≥ 2) with ejection fraction 35% or less, sinus rhythm and heart rate (HR) at least 70 bpm, despite maximally titrated β-blocker therapy. Data supporting this indication mainly derive from the SHIFT study, in which ivabradine reduced the combined endpoint of mortality and hospitalization, despite the fact that only 26% of patients enrolled were on optimal β-blocker doses. The aim of the present analysis is to establish the real-life eligibility for ivabradine in a population of patients with systolic heart failure, regularly attending a single heart failure clinic and treated according to guideline-directed medical therapy (GDMT). The clinical cards of 308 patients with heart failure with reduced ejection fraction (HFrEF) through a 68-month period of observation were retrospectively analyzed. GDMT, including β-blocker up-titration to maximal tolerated dose, was implemented during consecutive visits at variable intervals. Demographic, clinical and echocardiographic data were collected at each visit, together with 12-leads ECG and N-terminal pro-B-type natriuretic peptide levels. Out of 308 analyzed HFrEF patients, 220 (71%) were on effective β-blocker therapy, up-titrated to effective/maximal tolerated dose (55 ± 28% of maximal dose) (HR 67 ± 10 bpm). Among the remaining 88 patients, 10 (3.2%) were on maximally tolerated β blocker and ivabradine; 21 patients (6.8%), despite being on maximal tolerated β-blocker dose, had still HR ≥70 bpm, ejection fraction 35% or less and were symptomatic NYHA ≥2, being therefore eligible for ivabradine treatment. The remaining 57 (18%) patients were not on β blocker due to either intolerance or major contraindications. Among

  12. Time-Frequency Feature Representation Using Multi-Resolution Texture Analysis and Acoustic Activity Detector for Real-Life Speech Emotion Recognition

    Directory of Open Access Journals (Sweden)

    Kun-Ching Wang

    2015-01-01

    Full Text Available The classification of emotional speech is mostly considered in speech-related research on human-computer interaction (HCI. In this paper, the purpose is to present a novel feature extraction based on multi-resolutions texture image information (MRTII. The MRTII feature set is derived from multi-resolution texture analysis for characterization and classification of different emotions in a speech signal. The motivation is that we have to consider emotions have different intensity values in different frequency bands. In terms of human visual perceptual, the texture property on multi-resolution of emotional speech spectrogram should be a good feature set for emotion classification in speech. Furthermore, the multi-resolution analysis on texture can give a clearer discrimination between each emotion than uniform-resolution analysis on texture. In order to provide high accuracy of emotional discrimination especially in real-life, an acoustic activity detection (AAD algorithm must be applied into the MRTII-based feature extraction. Considering the presence of many blended emotions in real life, in this paper make use of two corpora of naturally-occurring dialogs recorded in real-life call centers. Compared with the traditional Mel-scale Frequency Cepstral Coefficients (MFCC and the state-of-the-art features, the MRTII features also can improve the correct classification rates of proposed systems among different language databases. Experimental results show that the proposed MRTII-based feature information inspired by human visual perception of the spectrogram image can provide significant classification for real-life emotional recognition in speech.

  13. Effectiveness and tolerability of second-line therapy with vildagliptin vs. other oral agents in type 2 diabetes: A real-life worldwide observational study (EDGE)

    Science.gov (United States)

    Mathieu, C; Barnett, A H; Brath, H; Conget, I; de Castro, J J; Göke, R; Márquez Rodriguez, E; Nilsson, P M; Pagkalos, E; Penfornis, A; Schaper, NC; Wangnoo, S K; Kothny, W; Bader, G

    2013-01-01

    Aim Real-life studies are needed to confirm the clinical relevance of findings from randomised controlled trials (RCTs). This study aimed to assess the effectiveness and tolerability of vildagliptin add-on vs. other oral antihyperglycaemic drugs (OADs) added to OAD monotherapy in a real-life setting, and to explore the advantages and limitations of large-scale ‘pragmatic’ trials. Methods EDGE was a prospective, 1-year, worldwide, real-life observational study in which 2957 physicians reported on the effects of second-line OADs in 45,868 patients with T2DM not reaching glycaemic targets with monotherapy. Physicians could add any OAD, and patients entered either vildagliptin or (pooled) comparator cohort. The primary effectiveness and tolerability end-point (PEP) evaluated proportions of patients decreasing HbA1c > 0.3%, without hypoglycaemia, weight gain, peripheral oedema or gastrointestinal side effects. The most clinically relevant secondary end-point (SEP 3) was attainment of end-point HbA1c vildagliptin-based regimen. The adjusted odds ratio was 1.49 (95% CI: 1.42, 1.55; p vildagliptin-based combination and by 23% of those receiving comparator combinations. The adjusted odds ratio was 1.96 (95% CI: 1.85, 2.07; p vildagliptin and other OADs were consistent with previous data. Conclusion EDGE demonstrates that in a ‘real-life’ setting, vildagliptin as second OAD can lower HbA1c to target without well-recognised OAD side effects, more frequently than comparator OADs. In addition, EDGE illustrates that conducting large-scale, prospective, real-life studies poses challenges but yields valuable clinical information complementary to RCTs. PMID:23961850

  14. Does a 20-week aerobic exercise training programme increase our capabilities to buffer real-life stressors? A randomized, controlled trial using ambulatory assessment.

    Science.gov (United States)

    von Haaren, Birte; Ottenbacher, Joerg; Muenz, Julia; Neumann, Rainer; Boes, Klaus; Ebner-Priemer, Ulrich

    2016-02-01

    The cross-stressor adaptation hypothesis suggests that regular exercise leads to adaptations in the stress response systems that induce decreased physiological responses to psychological stressors. Even though an exercise intervention to buffer the detrimental effects of psychological stressors on health might be of utmost importance, empirical evidence is mixed. This may be explained by the use of cross-sectional designs and non-personally relevant stressors. Using a randomized controlled trial, we hypothesized that a 20-week aerobic exercise training does reduce physiological stress responses to psychological real-life stressors in sedentary students. Sixty-one students were randomized to either a control group or an exercise training group. The academic examination period (end of the semester) served as a real-life stressor. We used ambulatory assessment methods to assess physiological stress reactivity of the autonomic nervous system (heart rate variability: LF/HF, RMSSD), physical activity and perceived stress during 2 days of everyday life and multilevel models for data analyses. Aerobic capacity (VO2max) was assessed pre- and post-intervention via cardiopulmonary exercise testing to analyze the effectiveness of the intervention. During real-life stressors, the exercise training group showed significantly reduced LF/HF (β = -0.15, t = -2.59, p = .01) and increased RMSSD (β = 0.15, t = 2.34, p = .02) compared to the control group. Using a randomized controlled trial and a real-life stressor, we could show that exercise appears to be a useful preventive strategy to buffer the effects of stress on the autonomic nervous system, which might result into detrimental health outcomes.

  15. Management of bipolar disorder in the intercontinental region: an international, multicenter, non-interventional, cross-sectional study in real-life conditions.

    Science.gov (United States)

    Samalin, Ludovic; Vieta, Eduard; Okasha, Tarek Ahmed; Uddin, Mm Jalal; Ahmadi Abhari, Seyed Ali; Nacef, Fethi; Mishyiev, Vyacheslav; Aizenberg, Dovi; Ratner, Yaël; Melas-Melt, Lydie; Sedeki, Idir; Llorca, Pierre Michel

    2016-05-16

    Most of the existing data on real-life management of bipolar disorder are from studies conducted in western countries (mostly United States and Europe). This multinational, observational cohort study aimed to describe the management and clinical outcomes of bipolar patients in real-life conditions across various intercontinental countries (Bangladesh, Egypt, Iran, Israel, Tunisia, and Ukraine). Data on socio-demographic and disease characteristics, current symptomatology, and pharmacological treatment were collected. Comparisons between groups were performed using standard statistical tests. Overall, 1180 patients were included. The median time from initial diagnosis was 80 months. Major depressive disorder was the most common initial diagnosis. Mood stabilizers and antipsychotics were the most common drugs being prescribed at the time of the study. Antidepressants (mainly selective serotonin uptake inhibitors [SSRIs]) were administered to 36.1% of patients. Patients with bipolar I disorder received higher number of antipsychotics and anxiolytics than those with bipolar II disorder (p Bipolar disorder real-life management practice, irrespective of region, shows a delay in diagnosis and an overuse of antidepressants. Clinical decision-making appears to be based on a multidimensional approach related to current symptomatology and type of bipolar disorder.

  16. SAROTA: application of specific absorption rate (SAR) and over-the-air (OTA) data for the characterization of the real-life exposure due to mobile phones

    International Nuclear Information System (INIS)

    Monebhurrun, Vikass

    2013-01-01

    The RF exposure level of a mobile phone is quantified by the measurement of the specific absorption rate (SAR) under laboratory conditions. The SAR which is measured while the mobile phone is operated at maximum power level does not reflect the real-life exposure scenario since the mobile phone typically re-adjusts its power level and frequency depending on the quality of the communication link with the nearest base station. The choice of a low RF exposure device based on the comparison of the relative SAR values of mobile phones can be misleading. The real-life RF exposure also depends on the over-the-air (OTA) performance of the mobile phone. Taken independently, the two sets of data do not allow a straightforward comparison of the global RF performance amongst mobile phones. A unique and simple parameter denoted as the SAROTA index is proposed for the characterization of mobile phones with regard to both RF exposure and OTA performance. The SAROTA index provides the real-life exposure index of the mobile phone.

  17. Automatic Generation of Test Cases from UML Models

    Directory of Open Access Journals (Sweden)

    Constanza Pérez

    2018-04-01

    Full Text Available [Context] The growing demand for high-quality software has caused the industry to incorporate processes to enable them to comply with these standards, but increasing the cost of development. A strategy to reduce this cost is to incorporate quality evaluations from early stages of software development. A technique that facilitates this evaluation is the model-based testing, which allows to generate test cases at early phases using as input the conceptual models of the system. [Objective] In this paper, we introduce TCGen, a tool that enables the automatic generation of abstract test cases starting from UML conceptual models. [Method] The design and implementation of TCGen, a technique that applies different testing criteria to class diagrams and state transition diagrams to generates test cases, is presented as a model-based testing approach. To do that, TCGen uses UML models, which are widely used at industry and a set of algorithms that recognize the concepts in the models in order to generate abstract test cases. [Results] An exploratory experimental evaluation has been performed to compare the TCGen tool with traditional testing. [Conclusions] Even though the exploratory evaluation shows promising results, it is necessary to perform more empirical evaluations in order to generalize the results. Abstract (in Spanish: [Contexto] La creciente demanda de software de alta calidad ha provocado que la industria incorpore procesos para permitirles cumplir con estos estándares, pero aumentando el costo del desarrollo. Una estrategia para reducir este costo es incorporar evaluaciones de calidad desde las primeras etapas del desarrollo del software. Una técnica que facilita esta evaluación es la prueba basada en modelos, que permite generar casos de prueba en fases tempranas utilizando como entrada los modelos conceptuales del sistema. [Objetivo] En este artículo, presentamos TCGen, una herramienta que permite la generación automática de casos de

  18. Performance Evaluation of State of the Art Systems for Physical Activity Classification of Older Subjects Using Inertial Sensors in a Real Life Scenario: A Benchmark Study.

    Science.gov (United States)

    Awais, Muhammad; Palmerini, Luca; Bourke, Alan K; Ihlen, Espen A F; Helbostad, Jorunn L; Chiari, Lorenzo

    2016-12-11

    The popularity of using wearable inertial sensors for physical activity classification has dramatically increased in the last decade due to their versatility, low form factor, and low power requirements. Consequently, various systems have been developed to automatically classify daily life activities. However, the scope and implementation of such systems is limited to laboratory-based investigations. Furthermore, these systems are not directly comparable, due to the large diversity in their design (e.g., number of sensors, placement of sensors, data collection environments, data processing techniques, features set, classifiers, cross-validation methods). Hence, the aim of this study is to propose a fair and unbiased benchmark for the field-based validation of three existing systems, highlighting the gap between laboratory and real-life conditions. For this purpose, three representative state-of-the-art systems are chosen and implemented to classify the physical activities of twenty older subjects (76.4 ± 5.6 years). The performance in classifying four basic activities of daily life (sitting, standing, walking, and lying) is analyzed in controlled and free living conditions. To observe the performance of laboratory-based systems in field-based conditions, we trained the activity classification systems using data recorded in a laboratory environment and tested them in real-life conditions in the field. The findings show that the performance of all systems trained with data in the laboratory setting highly deteriorates when tested in real-life conditions, thus highlighting the need to train and test the classification systems in the real-life setting. Moreover, we tested the sensitivity of chosen systems to window size (from 1 s to 10 s) suggesting that overall accuracy decreases with increasing window size. Finally, to evaluate the impact of the number of sensors on the performance, chosen systems are modified considering only the sensing unit worn at the lower back

  19. Performance Evaluation of State of the Art Systems for Physical Activity Classification of Older Subjects Using Inertial Sensors in a Real Life Scenario: A Benchmark Study

    Directory of Open Access Journals (Sweden)

    Muhammad Awais

    2016-12-01

    Full Text Available The popularity of using wearable inertial sensors for physical activity classification has dramatically increased in the last decade due to their versatility, low form factor, and low power requirements. Consequently, various systems have been developed to automatically classify daily life activities. However, the scope and implementation of such systems is limited to laboratory-based investigations. Furthermore, these systems are not directly comparable, due to the large diversity in their design (e.g., number of sensors, placement of sensors, data collection environments, data processing techniques, features set, classifiers, cross-validation methods. Hence, the aim of this study is to propose a fair and unbiased benchmark for the field-based validation of three existing systems, highlighting the gap between laboratory and real-life conditions. For this purpose, three representative state-of-the-art systems are chosen and implemented to classify the physical activities of twenty older subjects (76.4 ± 5.6 years. The performance in classifying four basic activities of daily life (sitting, standing, walking, and lying is analyzed in controlled and free living conditions. To observe the performance of laboratory-based systems in field-based conditions, we trained the activity classification systems using data recorded in a laboratory environment and tested them in real-life conditions in the field. The findings show that the performance of all systems trained with data in the laboratory setting highly deteriorates when tested in real-life conditions, thus highlighting the need to train and test the classification systems in the real-life setting. Moreover, we tested the sensitivity of chosen systems to window size (from 1 s to 10 s suggesting that overall accuracy decreases with increasing window size. Finally, to evaluate the impact of the number of sensors on the performance, chosen systems are modified considering only the sensing unit worn

  20. Management of COPD in the UK primary-care setting: an analysis of real-life prescribing patterns

    Directory of Open Access Journals (Sweden)

    Price D

    2014-08-01

    Full Text Available David Price,1 Daniel West,2 Guy Brusselle,3–5 Kevin Gruffydd-Jones,6 Rupert Jones,7 Marc Miravitlles,8 Andrea Rossi,9 Catherine Hutton,2 Valerie L Ashton,2 Rebecca Stewart,2 Katsiaryna Bichel2 1Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK; 2Research in Real-Life Ltd, Cambridge, UK; 3Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; 4Department of Epidemiology, 5Department of Respiratory Medicine, Erasmus Medical Center, Rotterdam, the Netherlands; 6Box Surgery, Wiltshire, UK; 7Centre for Clinical Trials and Health Research – Translational and Stratified Medicine, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth UK; 8Department of Pneumology, Hospital Universitari Vall d'Hebron, Ciber de Enfermedades Respiratorias (CIBERES, Barcelona, Spain; 9Pulmonary Unit, Cardiovascular and Thoracic Department, University and General Hospital, Verona, Italy Background: Despite the availability of national and international guidelines, evidence suggests that chronic obstructive pulmonary disease (COPD treatment is not always prescribed according to recommendations. This study evaluated the current management of patients with COPD using a large UK primary-care database. Methods: This analysis used electronic patient records and patient-completed questionnaires from the Optimum Patient Care Research Database. Data on current management were analyzed by the Global Initiative for Chronic Obstructive Lung Disease (GOLD group and presence or absence of a concomitant asthma diagnosis, in patients with a COPD diagnosis at ≥35 years of age and with spirometry results supportive of the COPD diagnosis. Results: A total of 24,957 patients were analyzed, of whom 13,557 (54.3% had moderate airflow limitation (GOLD Stage 2 COPD. The proportion of patients not receiving pharmacologic treatment for COPD was 17.0% in the total COPD population and 17.7% in the GOLD Stage 2 subset. Approximately

  1. Live theatre as exception and test case for experiencing negative emotions in art.

    Science.gov (United States)

    Goldstein, Thalia R

    2017-01-01

    Distancing and then embracing constitutes a useful way of thinking about the paradox of aesthetic pleasure. However, the model does not account for live theatre. When live actors perform behaviors perceptually close to real life and possibly really experienced by the actors, audiences may experience autonomic reactions, with less distance, or may have to distance post-experiencing/embracing their emotions.

  2. DECOVALEX I - Test Case 1: Coupled stress-flow model

    International Nuclear Information System (INIS)

    Rosengren, L.; Christianson, M.

    1995-12-01

    This report presents the results of the coupled stress-flow model, test case 1 of Decovalex. The model simulates the fourth loading cycle of a coupled stress-flow test and subsequent shearing up to and beyond peak shear resistance. The first loading sequence (A) consists of seven normal loading steps: 0, 5, 15, 25, 15, 5, 0 MPa. The second loading sequence (B) consists of the following eight steps: unstressed state, normal boundary loading of 25 MPa (no shearing), and then shearing of 0.5, 0.8, 2, 4, 2, 0 mm. Two different options regarding the rock joint behaviour were modeled in accordance with the problem definition. In option 1 a linear elastic joint model with Coulomb slip criterion was used. In option 2 a non-linear empirical (i.e. Barton-Bandis) joint model was used. The hydraulic condition during both load sequence A and B was a constant head of 5 m at the inlet point and 0 m at the outlet point. All model runs presented in this report were performed using the two-dimensional distinct element computer code UDEC, version 1.8. 30 refs, 36 figs

  3. Automated Test Case Generation for an Autopilot Requirement Prototype

    Science.gov (United States)

    Giannakopoulou, Dimitra; Rungta, Neha; Feary, Michael

    2011-01-01

    Designing safety-critical automation with robust human interaction is a difficult task that is susceptible to a number of known Human-Automation Interaction (HAI) vulnerabilities. It is therefore essential to develop automated tools that provide support both in the design and rapid evaluation of such automation. The Automation Design and Evaluation Prototyping Toolset (ADEPT) enables the rapid development of an executable specification for automation behavior and user interaction. ADEPT supports a number of analysis capabilities, thus enabling the detection of HAI vulnerabilities early in the design process, when modifications are less costly. In this paper, we advocate the introduction of a new capability to model-based prototyping tools such as ADEPT. The new capability is based on symbolic execution that allows us to automatically generate quality test suites based on the system design. Symbolic execution is used to generate both user input and test oracles user input drives the testing of the system implementation, and test oracles ensure that the system behaves as designed. We present early results in the context of a component in the Autopilot system modeled in ADEPT, and discuss the challenges of test case generation in the HAI domain.

  4. BEAT: A Web-Based Boolean Expression Fault-Based Test Case Generation Tool

    Science.gov (United States)

    Chen, T. Y.; Grant, D. D.; Lau, M. F.; Ng, S. P.; Vasa, V. R.

    2006-01-01

    BEAT is a Web-based system that generates fault-based test cases from Boolean expressions. It is based on the integration of our several fault-based test case selection strategies. The generated test cases are considered to be fault-based, because they are aiming at the detection of particular faults. For example, when the Boolean expression is in…

  5. Predictors for the initiation of a basal supported oral therapy (BOT) in type 2 diabetic patients under real-life conditions in Germany.

    Science.gov (United States)

    Kostev, Karel; Dippel, Franz-Werner

    2012-12-01

    To assess the predictors for the initiation of a basal supported oral therapy (BOT) in type 2 diabetic patients under real-life conditions in Germany. A historical cohort study based on representative German real life data (IMS(®) Disease Analyzer) was performed. The study included patients with type 2 diabetes who started an oral antidiabetic drug (OAD) treatment between 01/1995 and 12/2011. Patients with consecutive treatment data for at least 12 months before the initiation of an OAD treatment were eligible for the analysis. The time-dependent rate of patients starting an insulin therapy with a long-acting insulin was calculated by use of the Kaplan-Meier method. Multivariate Cox regression analyses were applied to identify associated factors. The study included 194,967 patients with type 2 diabetes mellitus being on OAD therapy. 24,964 patients were switched to BOT during the observational period. The probability of switching to insulin therapy was associated with three main predictors such as (1) poor metabolic control, (2) midlife age and (3) number and type of the OAD before insulinization. The variation of the HbA1c threshold to HbA1c≥7.5 leads to comparable outcomes with significant HR. The highest probability of initiating a basal supported oral therapy (BOT) under real life conditions was found for patients with poor metabolic control, midlife age and pre-treatment with specific OADs such as SU, GLI or AGI before initiation of insulin therapy. Copyright © 2012 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

  6. Estimation of Tri-Axial Walking Ground Reaction Forces of Left and Right Foot from Total Forces in Real-Life Environments

    Directory of Open Access Journals (Sweden)

    Erfan Shahabpoor

    2018-06-01

    Full Text Available Continuous monitoring of natural human gait in real-life environments is essential in many applications including disease monitoring, rehabilitation, and professional sports. Wearable inertial measurement units are successfully used to measure body kinematics in real-life environments and to estimate total walking ground reaction forces GRF(t using equations of motion. However, for inverse dynamics and clinical gait analysis, the GRF(t of each foot is required separately. Using an experimental dataset of 1243 tri-axial separate-foot GRF(t time histories measured by the authors across eight years, this study proposes the ‘Twin Polynomial Method’ (TPM to estimate the tri-axial left and right foot GRF(t signals from the total GRF(t signals. For each gait cycle, TPM fits polynomials of degree five, eight, and nine to the known single-support part of the left and right foot vertical, anterior-posterior, and medial-lateral GRF(t signals, respectively, to extrapolate the unknown double-support parts of the corresponding GRF(t signals. Validation of the proposed method both with force plate measurements (gold standard in the laboratory, and in real-life environment showed a peak-to-peak normalized root mean square error of less than 2.5%, 6.5% and 7.5% for the estimated GRF(t signals in the vertical, anterior-posterior and medial-lateral directions, respectively. These values show considerable improvement compared with the currently available GRF(t decomposition methods in the literature.

  7. Time-Optimal Real-Time Test Case Generation using UPPAAL

    DEFF Research Database (Denmark)

    Hessel, Anders; Larsen, Kim Guldstrand; Nielsen, Brian

    2004-01-01

    Testing is the primary software validation technique used by industry today, but remains ad hoc, error prone, and very expensive. A promising improvement is to automatically generate test cases from formal models of the system under test. We demonstrate how to automatically generate real...... test purposes or generated automatically from various coverage criteria of the model.......-time conformance test cases from timed automata specifications. Specifically we demonstrate how to fficiently generate real-time test cases with optimal execution time i.e test cases that are the fastest possible to execute. Our technique allows time optimal test cases to be generated using manually formulated...

  8. Clinical Characteristics of Patients with Newly Diagnosed Diabetic Macular Edema in Turkey: A Real-Life Registry Study—TURK-DEM

    Directory of Open Access Journals (Sweden)

    Bora Eldem

    2017-01-01

    Full Text Available Purpose. To evaluate the clinical and diagnostic characteristics of patients with newly diagnosed diabetic macular edema (DME in Turkey in a real-life setting. Methods. A total of 945 consecutive patients (mean (SD age: 61.3 (9.9 years, 55.2% male with newly diagnosed DME were included. Data on patient demographics, comorbidities, ocular history, ophthalmic examination findings including type of DME, central macular thickness (CMT via time domain (TD and spectral domain (SD optical coherence tomography (OCT, and planned treatments were recorded. Results. OCT (98.8% and fundoscopy (92.9% were the two most common diagnostic methods. Diffuse and focal DMEs were detected in 39.2% and 36.9% of cases, respectively. Laser photocoagulation (32.1% and antivascular endothelial growth factors (anti-VEGF; 31.8% were the most commonly planned treatments. The median CMT in the right eye was significantly greater in untreated than in treated patients [376.5 μm (range: 160–840 versus 342 μm (range: 146–999 (p=0.002] and in the left eye [370 μm (range: 201–780 versus 329 μm (range: 148–999 (p<0.001]. Conclusions. This study is the first large-scale real-life registry of DME patients in Turkey. SD-OCT and fundoscopy were the most common diagnostic methods. Laser photocoagulation and anti-VEGF therapy were the most common treatments.

  9. Omalizumab for severe allergic asthma in clinical trials and real-life studies: what we know and what we should address.

    Science.gov (United States)

    Caminati, Marco; Senna, Gianenrico; Guerriero, Massimo; Dama, Anna Rita; Chieco-Bianchi, Fulvia; Stefanizzi, Giorgia; Montagni, Marcello; Ridolo, Erminia

    2015-04-01

    Randomized clinical trials (RCTs) are the gold standard for the assessment of any therapeutic intervention. Real-life (R-L) studies are needed to verify the provided results beyond the experimental setting. This review aims at comparing RCTs and R-L studies on omalizumab in adult severe allergic asthma, in order to highlight the concurring results and the discordant/missing data. The results of a selective literature research, including "omalizumab, controlled studies, randomized trial, real-life studies" as key words are discussed. Though some similarities between RCTs and R-L studies strengthen omalizumab efficacy and safety outcomes, significant differences concerning study population features, follow-up duration, local adverse events and drop-out rate for treatment inefficacy emerge between the two study categories. Furthermore the comparative analysis between RCTs and R-L studies highlights the need for further research, concerning in particular long-term effects of omalizumab and its impact on asthma comorbidities. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Long-term Course of Alzheimer Disease in Patients Treated According to the Dutch Dementia Guideline at a Memory Clinic: A "Real-Life" Study.

    Science.gov (United States)

    Droogsma, Erika; van Asselt, Dieneke; van Steijn, Jolanda; Diekhuis, Marjolein; Veeger, Nic; De Deyn, Peter P

    2016-01-01

    There is little knowledge of the long-term course of Alzheimer disease (AD) in light of current pharmacological and nonpharmacological interventions provided in a "real-life" setting. The Frisian Alzheimer's Disease Cohort study is a "real-life" study of the course of AD in patients (n=576) treated with pharmacological (ie, cholinesterase inhibitors) and nonpharmacological (ie, case management, respite care) interventions. Disease course was described by changes in cognition (Mini Mental State Examination, clock-drawing test) and number of types of professional care applying a repeated-measures analysis using a marginal model (population-based average model). In addition, behavioral and psychological symptoms, and proportions of nursing home admissions and deaths were investigated. During 3.5 years, the average Mini Mental State Examination decreased from 22.24 to 18.91, the clock-drawing test score increased from 3.38 to 4.05, the number of types of professional care increased from 0.85 to 2.64, and the patients with behavioral and psychological symptoms increased from 29.0% to 70.2%. The proportion of patients admitted to a nursing home was 40.8% and 41.0% died. Cognition and behaviour of AD patients deteriorated accompanied with an increase in care-dependency during 3.5 years. Nevertheless, compared with the precholinesterase inhibitor era, current pharmacological and nonpharmacological interventions appear to slow cognitive decline, which emphasizes that they seem to have a favorable effect.

  11. How does Euro NCAP results correlate to real life injury risks - a paired comparison study of car-to-car crashes in Sweden

    Energy Technology Data Exchange (ETDEWEB)

    Lie, A. [Swedish National Road Administration, Borlaenge (Sweden)]|[ Karolinska Institutet (Sweden); Tingvall, C. [Monash University, Accident Research Centre (Australia)

    2001-07-01

    Euro NCAP is a resource for consumers regarding vehicle crash safety. The program also promotes safety developments, and credits car manufacturers focussing on safety. This study, based on real life car to car crashes, shows that the overall indication of the safety level, provided by the crash testing, is a valid prediction, at least when looking at the star rating and severe to fatal injuries. For minor injuries no significant injury risk differences are seen. The cars with three or four stars are approximately 30% safer, compared to two star cars or cars without an Euro NCAP score, in car to car collisions. The good general correlation between injury risk, and Euro NCAP scores is not necessarily similarly good for individual car models. Pedestrian safety and child occupant protection was not studied. (orig.)

  12. The use of ICP-MS and LA-ICP-MS techniques for uranium analysis in real-life swipe samples for safeguards purposes

    International Nuclear Information System (INIS)

    Pestana, Rafael C.B.; Sarkis, Jorge E.S.; Carvalho, Elita F.U.; Abreu Junior, Cassio H.

    2013-01-01

    Environmental swipe sampling for safeguards purposes is a powerful tool to detect undeclared materials and activities, and has been used by the International Atomic Energy Agency since 1997. This work describes the utilization of the inductively coupled plasma mass spectrometry (ICP-MS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for determining uranium isotopic ratios in a real-life swipe samples collected in a conversion plant at IPEN/CNEN, Brazil. Uncertainties were estimated by following the International Organization for Standardization - Guide to the Expression of Uncertainties in Measurement (ISO GUM), with a confidence level of 95%. The major uncertainties percentage for n( 235 U)/n( 238 U) ratio for ICP-MS was 3% and for LA-ICP-MS was 30% The values of uranium isotopic ratios obtained for each technique demonstrate the viability of these analytical techniques as an alternative tool for uranium analysis in swipe samples for safeguards purposes. (author)

  13. Differences between clinical "snap-shot" and "real-life" assessments of lumbar spine alignment and motion - What is the "real" lumbar lordosis of a human being?

    Science.gov (United States)

    Dreischarf, Marcel; Pries, Esther; Bashkuev, Maxim; Putzier, Michael; Schmidt, Hendrik

    2016-03-21

    The individual lumbar lordosis and lumbar motion have been identified to play an important role in pathogenesis of low back pain and are essential references for preoperative planning and postoperative evaluation. The clinical "gold-standard" for measuring lumbar lordosis and its motion are radiological "snap-shots" taken while standing and during upper-body flexion and extension. The extent to which these clinically assessed values characterise lumbar alignment and its motion in daily life merits discussion. A non-invasive measurement-system was employed to measure lumbar lordosis and lumbar motion in 208 volunteers (age: 20-74yrs; ♀/♂: 115/93). For an initial short-term measurement, comparable with the clinical "snap-shot", lumbar lordosis and its motion were assessed while standing and during flexion and extension. Subsequently, volunteers were released to their daily lives while wearing the device, and measurements were performed during the following 24h. The average lumbar lordosis during 24h (8.0°) differed significantly from the standardised measurement while standing (33.3°). Ranges of motion were significantly different throughout the day compared to standing measurements. The influence of the factors age and gender on lordosis and its motion resulted in conflicting results between long- and short-term-measurements. In conclusion, results of short-term examinations differ considerably from the average values during real-life. These findings might be important for surgical planning and increase the awareness of the biomechanical challenges that spinal structures and implants face in real-life. Furthermore, long-term assessments of spinal alignment and motion during daily life can provide valid data on spinal function and can reveal the importance of influential factors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Impact of omalizumab in children from a middle-income country with severe therapy-resistant asthma: A real-life study.

    Science.gov (United States)

    Pitrez, Paulo M; de Souza, Rodrigo G; Roncada, Cristian; Heinzmann-Filho, Joao P; Santos, Giovana; Pinto, Leonardo A; Jones, Marcus H; Stein, Renato T

    2017-11-01

    Severe asthma in children is a global health problem. Severe therapy-resistant asthma (STRA) in children is a major clinical challenge due to persistent symptoms despite high doses of corticosteroids and results in high public health costs. Omalizumab (anti-IgE monoclonal antibody) has been described as an effective add-on therapy in these patients. The characteristics of children with STRA from low- and middle-income countries have scarcely been reported, and no real-life study has been published on the effects of omalizumab in this group of patients. The aim of our study is to report the first clinical real-life experiences with omalizumab in Brazilian children with STRA. Children (6-18 years old) from a referral center who were diagnosed with STRA were included in this retrospective study based on our clinical databases. The included children had undergone at least 6 months of omalizumab treatment and fulfilled the following initial criteria: 1) >6 years old; 2) a positive skin-prick test for at least one aeroallergen; and 3) a serum total IgE level between 30 and 1500 IU/mL. Clinical and lung function variables were analyzed before and after treatment. Fourteen children (mean age: 11.9 years; percentage female: 72%) were included in this study. Omalizumab treatment significantly increased control of the disease according to a standardized questionnaire administered at every visit (P omalizumab in Brazilian children with STRA significantly improved disease control, decreased hospitalizations, and allowed suspension of continuous oral corticosteroids. © 2017 Wiley Periodicals, Inc.

  15. Long-term stability of morphine, codeine, and 6-acetylmorphine in real-life whole blood samples, stored at -20°C.

    Science.gov (United States)

    Høiseth, Gudrun; Fjeld, Bente; Burns, Margrete Larsen; Strand, Dag Helge; Vindenes, Vigdis

    2014-06-01

    Stability of drugs during storage is important in forensic toxicology. For the analytes detected after intake of heroin (6-acetylmorphine (6-AM), morphine and codeine), long-time stability in real life whole blood samples are studied in only a small number of cases. Whole blood post mortem (n=37) and whole blood samples from living persons (n=22) containing morphine and codeine as well as 6-AM in blood or urine were selected. All cases represented intake of heroin. All samples contained fluoride and were initially analysed and stored in normal conditions (-20°C) for 4-9 years. All samples were then reanalysed using the same analytical methods and the results were compared. For samples from living persons, the median change in concentration was -3.7% for morphine and -5.3% for codeine. For post mortem samples, the median change in concentration was -12% for morphine and -11% for codeine. Both for samples from living persons and post mortem samples, the decrease in the concentrations from the original analysis to reanalysis were statistically significant for morphine and codeine. Regarding 6-AM, all living samples were negative at reanalysis. For post mortem samples, four cases still tested positive for 6-AM at reanalysis with a median change in the concentrations of -81%. There was no significant change in the morphine to codeine concentration ratios neither for living nor post mortem samples. This study showed that in real life whole blood samples, the concentrations of morphine and codeine are relatively stable during long-term storage at -20°C. 6-AM on the other hand, shows a considerable decrease in concentrations that is important to consider when interpreting results from reanalyses of forensic cases. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  16. Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience

    Directory of Open Access Journals (Sweden)

    La Mantia I

    2017-06-01

    Full Text Available Ignazio La Mantia, Attilio Varricchio, Giorgio Ciprandi Associazione Italiana Vie Aeree Superiori, Naples, Italy Abstract: Recurrence of acute otitis media (RAOM is a relevant issue in the clinical practice. “Bacteriotherapy” has been proposed as an option in children with RAOM. Streptococcus salivarius 24SMB nasal spray has been previously demonstrated to reduce the risk of acute otitis media (AOM in otitis-prone children. The current retrospective and observational study aimed to confirm this outcome in a real-life setting, such as the common pediatric practice. Group A (108 children served as control; group B (159 children was treated with S. salivarius 24SMB and Streptococcus oralis 89a nasal spray after the first AOM episode. Active treatment consisted of 3 monthly courses: 2 puffs per nostril twice/day for a week. Group B showed a significant reduction of AOM episodes in comparison with group A (p<0.0001. Notably, all actively treated children with the highest AOM recurrence had a reduction of recurrence, whereas only 50% of the control group children had reduced RAOM (p<0.0001. Also, severity grade of AOM significantly diminished after the preventive bacteriotherapy (p<0.0001. In conclusion, the current retrospective and observational study demonstrated that S. salivarius 24SMB and S. oralis 89a nasal spray could be effective in the prevention of RAOM in a real-life setting. Keywords: recurrent acute otitis media, bacteriotherapy, Streptococcus salivarius 24SMB, Streptococcus oralis 89a, nasal spray, children

  17. Comparison of Optomap ultrawide-field imaging versus slit-lamp biomicroscopy for assessment of diabetic retinopathy in a real-life clinic

    Directory of Open Access Journals (Sweden)

    Purbrick RMJ

    2014-07-01

    Full Text Available Robert M J Purbrick, Shahrnaz Izadi, Ankur Gupta, N Victor Chong Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK Purpose: We aimed to assess the agreement between clinical assessment of diabetic retinopathy and Optomap ultrawide-field imaging (UWFI in a real-life clinic setting. Methods: Structured examination findings, from diabetic patients attending routine medical retina clinics in July 2011, were retrospectively compared with the grade obtained from Optomap UWFI images, graded independently by two ophthalmologists, taken at the same visit. Results: A total of 84 eyes (42 patients were examined, and 74 eyes (37 patients were suitable for analysis. The hospital Eye Service slit-lamp biomicroscopy grades for retinopathy were: no diabetic retinopathy in zero eyes; background retinopathy in 21 eyes; preproliferative retinopathy in 34 eyes; and proliferative retinopathy in 19 eyes. For retinopathy, the agreement between the Optomap UWFI and clinical grading was moderate for both graders (κ=0.57 and κ=0.63, and there was almost perfect agreement between the two graders (κ=0.92. The clinical grades for the presence of photocoagulation scars were: no photocoagulation scars in 46 eyes and photocoagulation scars visible in 28 eyes, indicating substantial agreement between the Optomap UWFI and clinical grading for both graders (κ=0.73 and κ=0.64. There were two instances where proliferative retinopathy was documented clinically but graded as preproliferative by both graders of Optomap UWFI. These were investigated, and neither patient required treatment, ie, the difference in retinopathy grade would not have affected the patient outcomes. Conclusion: This study demonstrated moderate agreement between Optomap UWFI and hospital slit-lamp biomicroscopy grading of patients’ retinopathy in a real-life medical retina clinic setting. The authors believe that Optomap UWFI is, not only a very useful adjunct to clinical examination in terms of

  18. Heterogeneity in barriers regarding the motivation, the opportunity and the ability to choose low-calorie snack foods and beverages: associations with real-life choices.

    Science.gov (United States)

    Bos, Colin; van der Lans, Ivo A; van Rijnsoever, Frank J; van Trijp, Hans Cm

    2016-06-01

    Employing Rothschild's Motivation-Opportunity-Ability framework, the present study examines the extent to which heterogeneity in barriers regarding the motivation, the perceived opportunity and the perceived ability to choose low-calorie over high-calorie snacks is associated with the proportion of low-calorie snack choices in real life. Furthermore, the study investigates which dominant barrier profiles can be discerned. Data were obtained from a survey about participants' motivation, opportunity and ability to choose low-calorie over high-calorie snacks and an FFQ that measured habitual consumption of snack foods and beverages. Data were analysed using R packages lavaan and NbClust, and IBM SPSS Statistics. A representative sample (n 1318) of the Dutch population based on gender (686 women), age and education level. For both snack foods and beverages, motivation to choose low-calorie over high-calorie snacks was associated strongest with proportions of low-calorie choices. The perceived ability and perceived opportunity were also associated with proportions of low-calorie choices, albeit to a lesser extent. Furthermore, three dominant profiles of barriers were identified: the no-barrier profile, the lack-of-opportunity profile and the lack-of-motivation profile. These profiles differed significantly on proportions of low-calorie snack choices, daily meal consumption and sociodemographic characteristics. Heterogeneity in barriers regarding the motivation, the perceived opportunity and the perceived ability to choose low-calorie over high-calorie snacks is associated with the proportion of low-calorie snack choices in real life. By identifying and appreciating heterogeneity in barriers, the present study provides further incentives for the tailoring of intervention strategies.

  19. Integration testing through reusing representative unit test cases for high-confidence medical software.

    Science.gov (United States)

    Shin, Youngsul; Choi, Yunja; Lee, Woo Jin

    2013-06-01

    As medical software is getting larger-sized, complex, and connected with other devices, finding faults in integrated software modules gets more difficult and time consuming. Existing integration testing typically takes a black-box approach, which treats the target software as a black box and selects test cases without considering internal behavior of each software module. Though it could be cost-effective, this black-box approach cannot thoroughly test interaction behavior among integrated modules and might leave critical faults undetected, which should not happen in safety-critical systems such as medical software. This work anticipates that information on internal behavior is necessary even for integration testing to define thorough test cases for critical software and proposes a new integration testing method by reusing test cases used for unit testing. The goal is to provide a cost-effective method to detect subtle interaction faults at the integration testing phase by reusing the knowledge obtained from unit testing phase. The suggested approach notes that the test cases for the unit testing include knowledge on internal behavior of each unit and extracts test cases for the integration testing from the test cases for the unit testing for a given test criteria. The extracted representative test cases are connected with functions under test using the state domain and a single test sequence to cover the test cases is produced. By means of reusing unit test cases, the tester has effective test cases to examine diverse execution paths and find interaction faults without analyzing complex modules. The produced test sequence can have test coverage as high as the unit testing coverage and its length is close to the length of optimal test sequences. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Cortical processing of pitch: Model-based encoding and decoding of auditory fMRI responses to real-life sounds.

    Science.gov (United States)

    De Angelis, Vittoria; De Martino, Federico; Moerel, Michelle; Santoro, Roberta; Hausfeld, Lars; Formisano, Elia

    2017-11-13

    Pitch is a perceptual attribute related to the fundamental frequency (or periodicity) of a sound. So far, the cortical processing of pitch has been investigated mostly using synthetic sounds. However, the complex harmonic structure of natural sounds may require different mechanisms for the extraction and analysis of pitch. This study investigated the neural representation of pitch in human auditory cortex using model-based encoding and decoding analyses of high field (7 T) functional magnetic resonance imaging (fMRI) data collected while participants listened to a wide range of real-life sounds. Specifically, we modeled the fMRI responses as a function of the sounds' perceived pitch height and salience (related to the fundamental frequency and the harmonic structure respectively), which we estimated with a computational algorithm of pitch extraction (de Cheveigné and Kawahara, 2002). First, using single-voxel fMRI encoding, we identified a pitch-coding region in the antero-lateral Heschl's gyrus (HG) and adjacent superior temporal gyrus (STG). In these regions, the pitch representation model combining height and salience predicted the fMRI responses comparatively better than other models of acoustic processing and, in the right hemisphere, better than pitch representations based on height/salience alone. Second, we assessed with model-based decoding that multi-voxel response patterns of the identified regions are more informative of perceived pitch than the remainder of the auditory cortex. Further multivariate analyses showed that complementing a multi-resolution spectro-temporal sound representation with pitch produces a small but significant improvement to the decoding of complex sounds from fMRI response patterns. In sum, this work extends model-based fMRI encoding and decoding methods - previously employed to examine the representation and processing of acoustic sound features in the human auditory system - to the representation and processing of a relevant

  1. Stopping Onabotulinum Treatment after the First Two Cycles Might Not Be Justified: Results of a Real-life Monocentric Prospective Study in Chronic Migraine

    Directory of Open Access Journals (Sweden)

    Paola Sarchielli

    2017-12-01

    Full Text Available IntroductionOnabotulinum toxin A (OnabotA cyclic treatment is approved for the prophylactic treatment of chronic migraine (CM, a highly disabling disorder. Although treatment response varies among patients, current guidelines suggest to stop treatment after cycle 2 if no response is achieved. This prospective study aimed to define, in real-life setting, the evolution of the response to OnabotA over five cycles of treatment among patients non-responding to cycle 1. The results of this study might help in decision-making, in particular whether prosecuting OnabotA further or not, when facing a patient not responding to cycle 1.MethodsPatients failing to respond at cycle 1 were recruited to complete five cycles. Key outcomes were: (i a ≥50% reduction in headache days, (ii a ≥50% reduction in total cumulative hours of headache on headache days and (iii a ≥5-point improvement in Headache Impact Test-6 (HIT-6 scores.ResultsOverall, 56 patients were included. Mean age was 45.7 years (female 83.9%. Severe (≥60 HIT-6 score was reported at baseline by 95.8% of patients. Responders (headache days reduction of more than 50% progressively increased cycle after cycle, doubling from cycle 2 to cycle 5 (from 27 to 48%. In addition, patients regressed from CM to episodic migraine moving on with each cycle, with 78% of them reaching less than nine migraine days/month after cycle 5. The headache days per month decreased significantly from cycle 1 to cycle 5 (overall from 23.3 ± 5.7 to 9.2 ± 3.6; p < 0.001. During 12 months (5 cycles, migraine days per month progressively abated (from 18.5 to 8.7; p < 0.001, days with symptomatic medications intake/month consistently decreased (from 17.4 to 8.1; p < 0.001, and mean HIT-6 score lowered (from 72.4 ± 5.7 to 50.2 ± 4.3; p < 0.001.ConclusionThe positive effect of OnabotA treatment spreads over the course of the treatment and might also manifest late in treatment course

  2. Interplay Among Psychopathologic Variables, Personal Resources, Context-Related Factors, and Real-life Functioning in Individuals With Schizophrenia: A Network Analysis.

    Science.gov (United States)

    Galderisi, Silvana; Rucci, Paola; Kirkpatrick, Brian; Mucci, Armida; Gibertoni, Dino; Rocca, Paola; Rossi, Alessandro; Bertolino, Alessandro; Strauss, Gregory P; Aguglia, Eugenio; Bellomo, Antonello; Murri, Martino Belvederi; Bucci, Paola; Carpiniello, Bernardo; Comparelli, Anna; Cuomo, Alessandro; De Berardis, Domenico; Dell'Osso, Liliana; Di Fabio, Fabio; Gelao, Barbara; Marchesi, Carlo; Monteleone, Palmiero; Montemagni, Cristiana; Orsenigo, Giulia; Pacitti, Francesca; Roncone, Rita; Santonastaso, Paolo; Siracusano, Alberto; Vignapiano, Annarita; Vita, Antonio; Zeppegno, Patrizia; Maj, Mario

    2018-04-01

    Enhanced understanding of factors associated with symptomatic and functional recovery is instrumental to designing personalized treatment plans for people with schizophrenia. To date, this is the first study using network analysis to investigate the associations among cognitive, psychopathologic, and psychosocial variables in a large sample of community-dwelling individuals with schizophrenia. To assess the interplay among psychopathologic variables, cognitive dysfunctions, functional capacity, personal resources, perceived stigma, and real-life functioning in individuals with schizophrenia, using a data-driven approach. This multicenter, cross-sectional study involved 26 university psychiatric clinics and/or mental health departments. A total of 921 community-dwelling individuals with a DSM-IV diagnosis of schizophrenia who were stabilized on antipsychotic treatment were recruited from those consecutively presenting to the outpatient units of the sites between March 1, 2012, and September 30, 2013. Statistical analysis was conducted between July 1 and September 30, 2017. Measures covered psychopathologic variables, neurocognition, social cognition, functional capacity, real-life functioning, resilience, perceived stigma, incentives, and service engagement. Of 740 patients (221 women and 519 men; mean [SD] age, 40.0 [10.9] years) with complete data on the 27 study measures, 163 (22.0%) were remitted (with a score of mild or better on 8 core symptoms). The network analysis showed that functional capacity and everyday life skills were the most central and highly interconnected nodes in the network. Psychopathologic variables split in 2 domains, with positive symptoms being one of the most peripheral and least connected nodes. Functional capacity bridged cognition with everyday life skills; the everyday life skills node was connected to disorganization and expressive deficits. Interpersonal relationships and work skills were connected to avolition; the interpersonal

  3. Real-life efficacy of pregabalin for the treatment of peripheral neuropathic pain in daily clinical practice in Denmark: the NEP-TUNE study

    Directory of Open Access Journals (Sweden)

    Crawford ME

    2016-05-01

    Full Text Available Michael E Crawford,1 Peter Bo Poulsen,2 Berit Schiøttz-Christensen,3 Andreas Habicht,4 Mette Strand,2 Flemming W Bach5 1Copenhagen City Pain Clinic, Copenhagen K, 2Pfizer Denmark ApS, Ballerup, 3Spine Center Southern Denmark, Lillebælt Hospital, Middelfart, 4Signifikans ApS, Vedbæk, 5Department of Neurology, Aalborg University Hospital, Aalborg, Denmark Objective: The aim of this study was to provide evidence regarding the real-life efficacy of pregabalin in the treatment of peripheral neuropathic pain (NeP in Denmark. Methods: In this prospective, observational, noninterventional study, pregabalin (Lyrica® was prescribed following usual clinical practice. Compared with baseline, the primary study end points after 3 months of observation were changes in 1 the average level of pain during the past week, 2 the worst level of pain during the past week, and 3 the least level of pain during the past week. The Wilcoxon signed-rank test was used to perform paired analyses, and a multivariate regression analysis investigated factors driving change in pain. Results: A total of 86 of the 128 patients included were regarded as efficacy evaluable (those completing 3 months of pregabalin treatment. Patients (59 years were long-time sufferers of peripheral NeP, and 38% of them had comorbidities. The majority had previously been treated with tricyclic antidepressants or gabapentin. The average dose of pregabalin was 81.5 mg/d at baseline and 240 mg/d after 3 months. A clinically and statistically significant improvement of 2.2 points in the average level of pain intensity was found after 3 months. The higher the pain intensity at baseline, the higher was the reduction of the pain score. Positive results were also found for pain-related sleep interference, patients’ global impression of change, quality of life, and work and productivity impairment. Twenty-one patients reported 28 adverse events. Conclusion: This real-life study indicates that for some

  4. Computer Screen or Real Life?

    DEFF Research Database (Denmark)

    Suurmets, Seidi; Clement, Jesper

    the allocation of visual attention actually depends on the study setting has not been investigated. Methods: In this study we used a withinsubject design where identical stimuli were presented to 60 female participants in two settings: 1) mobile, and 2) stationary. This was done with an interval of one month....... In mobile settings visual salience was less predictive of eye movement selections and the dwell times were longer. The stationary presentation of stimuli resulted in considerable central fixation bias and the locations of redwells were more spread out. The freeviewing condition resulted in highest...... variability between the two settings, but decreased when tasks and time pressure were introduced. Conclusions: These findings have ramifications for the deployment of eyetracking and help to transfer and generalise future findings acquired in lab settings to natural environments. In the context of marketing...

  5. How does a collision warning system shape driver's brake response time? The influence of expectancy and automation complacency on real-life emergency braking.

    Science.gov (United States)

    Ruscio, Daniele; Ciceri, Maria Rita; Biassoni, Federica

    2015-04-01

    Brake Reaction Time (BRT) is an important parameter for road safety. Previous research has shown that drivers' expectations can impact RT when facing hazardous situations, but driving with advanced driver assistance systems, can change the way BRT are considered. The interaction with a collision warning system can help faster more efficient responses, but at the same time can require a monitoring task and evaluation process that may lead to automation complacency. The aims of the present study are to test in a real-life setting whether automation compliancy can be generated by a collision warning system and what component of expectancy can impact the different tasks involved in an assisted BRT process. More specifically four component of expectancy were investigated: presence/absence of anticipatory information, previous direct experience, reliability of the device, and predictability of the hazard determined by repeated use of the warning system. Results supply indication on perception time and mental elaboration of the collision warning system alerts. In particular reliable warning quickened the decision making process, misleading warnings generated automation complacency slowing visual search for hazard detection, lack of directed experienced slowed the overall response while unexpected failure of the device lead to inattentional blindness and potential pseudo-accidents with surprise obstacle intrusion. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. Real-life radiation burden to relatives of patients treated with iodine-131: a study in eight centres in Flanders (Belgium)

    International Nuclear Information System (INIS)

    Monsieurs, M.; Thierens, H.; Dierckx, R.A.; Casier, K.; Simons, M.; Baere, E. de; Ridder, L. de; Saedeleer, C. de; Winter, H. de; Lippens, M.; Imschoot, S. van; Wulfrank, D.

    1998-01-01

    In view of the EURATOM 96/29 regulations, a prospective multicentre study was performed to evaluate the present guidelines given to relatives of patients treated with iodine-131 for both thyroid carcinoma and thyrotoxicosis, based on the real-life radiation burden. This study comprised 166 measurements carried out on a group of 94 relatives of 65 patients. All relatives wore a thermoluminescent dosemeter (TLD) on the wrist for 7 days. Sixty-one relatives agreed to wear another TLD for an additional 7 days. TLD were placed on nine patients' bedside tables. The eight participating centres were arbitrarily divided into three groups according to the period of time they advised their patients to sleep separately. Groups I, II and III respectively advised their patients to sleep separately for 0, 7-10 and 14-21 days. The median dose received by in-living relatives of thyroid carcinoma patients during the 14 days following hospital discharge was 281 μSv (doses to infinity not calculated); the median dose to infinity received by in-living relatives of ambulatory treated thyrotoxicosis patients was 596 μSv, as compared with 802 μSv for in-living relatives of hospitalised thyrotoxicosis patients. In general the children of patients received a significantly (P 131 I, while still following the ALARA principle. (orig.)

  7. Real-life safety and efficacy of vildagliptin as add-on to metformin in patients with type 2 diabetes in Turkey--GALATA study.

    Science.gov (United States)

    Ayvaz, Goksun; Keskin, Lezzan; Akin, Fulya; Dokmetas, Hatice Sebile; Tasan, Ertugrul; Ar, Idilhan Baloglu; Uren, Emel

    2015-04-01

    To evaluate tolerability/safety and the efficacy of the combination of vildagliptin plus metformin in a real-life population of patients with type 2 diabetes mellitus (T2DM). This multicenter, single-arm, 6 month, observational, prospective cohort study was conducted at 39 centers across Turkey. T2DM patients on vildagliptin and metformin for ≤4 weeks were enrolled regardless of their previous antidiabetic therapy. Efficacy was evaluated by measuring hemoglobin A1c (HbA1c) levels. Tolerability/safety parameters evaluated included hypoglycemic events, gastrointestinal events, peripheral edema and weight gain. This study enrolled 665 patients with a mean ± standard deviation (SD) age of 55.1 ± 10.2 years and female predominance (n = 394, 59.2%). Safety was assessed in all enrolled patients. Hypoglycemia was reported in 10 (1.5%) patients (95% confidence interval = 0.8-2.7%). Efficacy was assessed in 289 (43.5%) patients treated for 6 ± 1 months; these patients showed a mean decrease in HbA1c of 0.8% from baseline value of 7.8% (p 65 years) and body mass index (vildagliptin and metformin combination was associated with significant improvements in reaching target HbA1c levels, even in elderly and obese patients with T2DM. Moreover, vildagliptin and metformin demonstrated a good overall tolerability/safety profile.

  8. Developmental changes in real life decision making: performance on a gambling task previously shown to depend on the ventromedial prefrontal cortex.

    Science.gov (United States)

    Crone, Eveline A; van der Molen, Maurits W

    2004-01-01

    Patients with bilateral lesions of the ventromedial prefrontal cortex, when performing gambling tasks modeling real-life decision-making, opt for choices that yield high immediate gains in spite of higher future losses. Under the hypothesis that the prefrontal cortex is the last brain region to mature, it was examined whether young children would show a similar preference for immediate prospects. In Experiment 1, 4 age groups (6-9, 10-12, 13-15 and 18-25 years olds) performed 2 versions of a computerized variant of the original Iowa gambling task under 3 different feedback conditions (no feedback, global feedback, and option-specific feedback) and completed the Raven Standard Progressive Matrices as an index of inductive reasoning ability. In Experiment 2, 3 age groups (7-8, 11-12, and 15-16 year olds) performed both task versions in addition to a working memory task ("Digit Span Backwards"). Results showed a developmental increase in the sensitivity to future consequences, positive or negative, that could not be explained by developmental changes in working memory capacity or inductive reasoning. It was concluded that young children share with ventromedial prefrontal patients the failure to anticipate on future outcomes.

  9. Assessment and management of iron overload in β-thalassaemia major patients during the 21st century: a real-life experience from the Italian WEBTHAL project.

    Science.gov (United States)

    Piga, Antonio; Longo, Filomena; Musallam, Khaled M; Cappellini, Maria Domenica; Forni, Gian Luca; Quarta, Giovanni; Chiavilli, Francesco; Commendatore, Francesca; Mulas, Sergio; Caruso, Vincenzo; Galanello, Renzo

    2013-06-01

    We conducted a cross-sectional study on 924 β-thalassaemia major patients (mean age 30·1 years) treated at nine Italian centres using the WEBTHAL software, to evaluate real-life application of iron overload assessment and management standards. Serum ferritin 2 years. Patients who never had a cardiac MRI (CMR) T2* measurement were 2 years. Deferoxamine (22·8%) was more commonly used in patients with Hepatitis C Virus or high serum creatinine. Deferiprone (20·6%) was less commonly prescribed in patients with elevated alanine aminotransferase; while a deferoxamine + deferiprone combination (17·9%) was more commonly used in patients with serum ferritin >2500 ng/ml or CMR T2* <20 ms. Deferasirox (38·3%) was more commonly prescribed in patients <18 years, but less commonly used in those with heart disease or high iron intake. These observations largely echoed guidelines at the time, although some practices are expected to change in light of evolving evidence. © 2013 John Wiley & Sons Ltd.

  10. A reconceptualisation of Vygotsky’s ZPD into ZCD in teaching moral education in secondary schools using real-life dilemmas

    Directory of Open Access Journals (Sweden)

    Vishalache Balakrishnan

    2016-12-01

    Full Text Available In an effort to contribute to contemporary debates about alternative ways of teaching moral education, this qualitative study explored moral dilemmas identified by young adolescents and how they made moral choices to resolve the dilemmas. Data were gathered for textual analysis through a modified framework of participatory action research using participant observation, focus group transcripts, interviews and student journals. The data were interpreted using a revision of Vygotsky’s Zone of Proximal Development, extended to suit the multicultural Malaysian setting, and here called the Zone of Collaborative Development. Participants were 22 16–17-year-old non-Muslim adolescents from different cultural backgrounds attending three different types of secondary schools. Moral Education (ME in Malaysia (MEM is designed to cater to this group while Muslim students study Islamic Studies. Findings show that students were concerned about moral issues and values not covered in the current ME curriculum. The moral dilemmas identified were relational and context dependent. Students named autonomy, self and mutual respect, trust, freedom and tolerance as main conflicting themes in their real-life moral dilemmas. The study suggests that including students’ voices in MEM in this way might better engage students’ interest and connecting the subject with students’ everyday lives.

  11. Real-life setting in data collection. The role of nutrition knowledge whilst selecting food products for weight management purposes in a supermarket environment.

    Science.gov (United States)

    Saarela, Anna-Maria; Lapveteläinen, Anja T; Mykkänen, Hannu M; Kantanen, Teuvo T; Rissanen, Riitta L

    2013-12-01

    The aim was to explore the role of consumers' nutrition knowledge while selecting foods for weight management and the predominating food selection factors by combining quantitative and qualitative methodology in a real-life setting during two consecutive shopping tasks given in a supermarket. Thirty-six consumers were given a list of 11 products and asked to think-aloud while selecting (i) a product they usually buy and (ii) a product they use for weight management. After the consecutive shopping tasks, the subjects were interviewed and asked to answer a nutrition knowledge questionnaire. The subjects were categorized by the difference in the energy contents of their selections and the food selection criteria. The energy contents of the selections for weight management were reduced by 10-46%. Ten subjects with the greatest difference between the energy contents of their selections had higher level in nutrition knowledge and mentioned less nutritional issues during the selections than ten subjects with the smallest such differences. Taste was an important product selection criterion by the former group, while the latter focused primarily on price. Nutrition knowledge is interrelated with personal factors and selection goals. It is not necessarily utilized consistently when selecting food products. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. The use of ICP-MS and LA-ICP-MS techniques for uranium analysis in real-life swipe samples for safeguards purposes

    Energy Technology Data Exchange (ETDEWEB)

    Pestana, Rafael C.B.; Sarkis, Jorge E.S.; Carvalho, Elita F.U., E-mail: rcbpestana@gmail.com, E-mail: jesarkis@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Abreu Junior, Cassio H. [Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil)

    2013-07-01

    Environmental swipe sampling for safeguards purposes is a powerful tool to detect undeclared materials and activities, and has been used by the International Atomic Energy Agency since 1997. This work describes the utilization of the inductively coupled plasma mass spectrometry (ICP-MS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for determining uranium isotopic ratios in a real-life swipe samples collected in a conversion plant at IPEN/CNEN, Brazil. Uncertainties were estimated by following the International Organization for Standardization - Guide to the Expression of Uncertainties in Measurement (ISO GUM), with a confidence level of 95%. The major uncertainties percentage for n({sup 235}U)/n({sup 238}U) ratio for ICP-MS was 3% and for LA-ICP-MS was 30% The values of uranium isotopic ratios obtained for each technique demonstrate the viability of these analytical techniques as an alternative tool for uranium analysis in swipe samples for safeguards purposes. (author)

  13. Feasibility of Functional Near-Infrared Spectroscopy (fNIRS) to Investigate the Mirror Neuron System: An Experimental Study in a Real-Life Situation

    Science.gov (United States)

    Sun, Pei-Pei; Tan, Fu-Lun; Zhang, Zong; Jiang, Yi-Han; Zhao, Yang; Zhu, Chao-Zhe

    2018-01-01

    The mirror neuron system (MNS), mainly including the premotor cortex (PMC), inferior frontal gyrus (IFG), superior parietal lobule (SPL), and rostral inferior parietal lobule (IPL), has attracted extensive attention as a possible neural mechanism of social interaction. Owing to high ecological validity, functional near-infrared spectroscopy (fNIRS) has become an ideal approach for exploring the MNS. Unfortunately, for the feasibility of fNIRS to detect the MNS, none of the four dominant regions were found in previous studies, implying a very limited capacity of fNIRS to investigate the MNS. Here, we adopted an experimental paradigm in a real-life situation to evaluate whether the MNS activity, including four dominant regions, can be detected by using fNIRS. Specifically, 30 right-handed subjects were asked to complete a table-setting task that included action execution and action observation. A double density probe configuration covered the four regions of the MNS in the left hemisphere. We used a traditional channel-based group analysis and also a ROI-based group analysis to find which regions are activated during both action execution and action observation. The results showed that the IFG, adjacent PMC, SPL, and IPL were involved in both conditions, indicating the feasibility of fNIRS to detect the MNS. Our findings provide a foundation for future research to explore the functional role of the MNS in social interaction and various disorders using fNIRS. PMID:29556185

  14. The use of local concentrated heat versus topical acyclovir for a herpes labialis outbreak: results of a pilot study under real life conditions

    Directory of Open Access Journals (Sweden)

    Wohlrab J

    2013-11-01

    Full Text Available Johannes Wohlrab,1 Franziska Voß,2 Christian Müller,2 Lars C Brenn21Department of Dermatology and Venereology, Martin Luther University of Halle-Wittenberg, Halle, 2Department of Medical Science and Operations, Riemser Pharma GmbH, Greifswald, GermanyBackground: Frequent outbreak of herpes labialis can affect quality of life by prodromes like burning, itching, and swelling. Topical applied preparations aim to shorten the duration of symptoms, inhibit the virus replication and/or accelerate the healing process. Local concentrated heat (LCH can reduce burning, itching, or swelling of the skin by influence of mechano-heat sensitive afferent neurons.Patients and methods: To examine the effectiveness of two different topical applications (LCH versus topical acyclovir [TACV] under real life conditions, we conducted a prospective, observational, reference-controlled cohort pilot study with 103 patients. Occurrence of prodromal burning, itching, swelling, and quality of life were assessed.Results: The LCH observation group (OG showed a significantly faster improvement in all symptoms after 1-day of application than the TACV OG. The burden and duration of disease was lower and shorter in the LCH OG than in the TACV OG.Conclusions: The prodromal symptoms in recurrent herpes labialis were attenuated more effectively by LCH than by TACV.Keywords: herpes labialis, local concentrated heat, acyclovir

  15. Feasibility of Functional Near-Infrared Spectroscopy (fNIRS to Investigate the Mirror Neuron System: An Experimental Study in a Real-Life Situation

    Directory of Open Access Journals (Sweden)

    Pei-Pei Sun

    2018-03-01

    Full Text Available The mirror neuron system (MNS, mainly including the premotor cortex (PMC, inferior frontal gyrus (IFG, superior parietal lobule (SPL, and rostral inferior parietal lobule (IPL, has attracted extensive attention as a possible neural mechanism of social interaction. Owing to high ecological validity, functional near-infrared spectroscopy (fNIRS has become an ideal approach for exploring the MNS. Unfortunately, for the feasibility of fNIRS to detect the MNS, none of the four dominant regions were found in previous studies, implying a very limited capacity of fNIRS to investigate the MNS. Here, we adopted an experimental paradigm in a real-life situation to evaluate whether the MNS activity, including four dominant regions, can be detected by using fNIRS. Specifically, 30 right-handed subjects were asked to complete a table-setting task that included action execution and action observation. A double density probe configuration covered the four regions of the MNS in the left hemisphere. We used a traditional channel-based group analysis and also a ROI-based group analysis to find which regions are activated during both action execution and action observation. The results showed that the IFG, adjacent PMC, SPL, and IPL were involved in both conditions, indicating the feasibility of fNIRS to detect the MNS. Our findings provide a foundation for future research to explore the functional role of the MNS in social interaction and various disorders using fNIRS.

  16. Real-life Use of Anticoagulants in Venous Thromboembolism With a Focus on Patients With Exclusion Criteria for Direct Oral Anticoagulants.

    Science.gov (United States)

    Moustafa, Farès; Pesavento, Raffaele; di Micco, Pierpaolo; González-Martínez, José; Quintavalla, Roberto; Peris, Maria-Luisa; Porras, José Antonio; Falvo, Nicolas; Baños, Pilar; Monreal, Manuel

    2018-04-01

    We assessed the real-life use of direct oral anticoagulants (DOACs) in patients with venous thromboembolism (VTE) and exclusion criteria for randomized trials. From 2013 to 2016, 3,578 of 18,853 patients (19%) had exclusion criteria. Irrespective of which anticoagulant was chosen, they had more VTE recurrences (hazard ratio (HR): 3.10; 95% confidence interval (CI): 2.47-3.88), major bleeds (HR: 4.10; 95% CI: 3.38-4.96), and deaths (HR: 9.47; 95% CI: 8.46-10.6) than those without exclusion criteria. During initial therapy, no patient with exclusion criteria on DOACs (n = 115) recurred, but those on rivaroxaban bled less often (adjusted HR: 0.18; 95% CI: 0.04-0.79) than those on unfractionated heparin (n = 224) and similar to those (n = 3,172) on low-molecular-weight (LMWH) heparin. For long-term therapy, patients on rivaroxaban (n = 151) had nonsignificantly fewer VTE recurrences (adjusted HR: 0.74; 95% CI: 0.08-1.32) and major bleeds (adjusted HR: 0.41; 95% CI: 0.15-1.15) than those on LMWH (n = 2,071). The efficacy and safety of DOACs were similar to standard therapy. © 2017 American Society for Clinical Pharmacology and Therapeutics.

  17. Switching patients from other inhaled corticosteroid devices to the Easyhaler®: historical, matched-cohort study of real-life asthma patients

    Directory of Open Access Journals (Sweden)

    Price D

    2014-04-01

    Full Text Available David Price,1,2 Vicky Thomas,2 Julie von Ziegenweidt,2 Shuna Gould,2 Catherine Hutton,2 Christine King2 1Academic Centre of Primary Care, University of Aberdeen, Aberdeen, UK; 2Research in Real Life, Oakington, Cambridge, UK Purpose: To investigate the clinical and cost effectiveness of switching real-life asthma patients from other types of inhalers to the Easyhaler® (EH for the administration of inhaled corticosteroids (ICS. Patients and methods: Historical, matched-cohort study of 1,958 asthma patients (children and adults treated in UK primary-care practices, using data obtained from the Optimum Patient Care Research Database and Clinical Practice Research Datalink. Other inhalers (OH included pressurized metered-dose inhalers, breath-actuated inhalers, and dry-powder inhalers, delivering beclomethasone, budesonide, fluticasone, or ciclesonide. Patients remaining on OH unchanged (same drug, dosage, and device; n=979 were matched 1:1 with those switched to the EH (beclomethasone or budesonide at the same or lower ICS dosage (n=979, based on age, sex, year of index patient review/switch, most recent ICS drug, dosage, and device, and the number of severe exacerbations and average daily short-acting β2 agonist (SABA dosage in the preceding year. Clinical outcomes and health care costs were compared between groups for 12 months before and after the switch. Co-primary clinical outcomes were: 1 risk domain asthma control (RDAC – no asthma-related hospitalization, acute oral steroid use, or lower respiratory tract infection (LRTI; 2 exacerbation rate (American Thoracic Society [ATS] definition – where exacerbation is asthma-related hospitalization or acute oral steroid use; 3 exacerbation rate (clinical definition – where exacerbation is ATS exacerbation or LRTI; and 4 overall asthma control (OAC – RDAC plus average salbutamol-equivalent SABA dosage ≤200 μg/day. Non-inferiority (at least equivalence of EH was tested against OH for the

  18. Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis

    Directory of Open Access Journals (Sweden)

    Halpern N

    2017-03-01

    Full Text Available Naama Halpern,1 Yael Goldberg,2 Luna Kadouri,2 Morasha Duvdevani,2 Tamar Hamburger,2 Tamar Peretz,2 Ayala Hubert2 1Institute of Oncology, The Chaim Sheba Medical Center, Tel Hashomer, Israel; 2Sharett Institute of Oncology, Hadassah Medical Center, Hebrew University, Jerusalem, Israel Background: The prognostic and predictive significance of the high-level microsatellite instability (MSI-H phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting.Patients and methods: A retrospective analysis of MSI-H cancer patient files was conducted. We analyzed the genetic data, clinical characteristics, and oncological treatments, including chemotherapy and surgical interventions.Results: Clinical data of 73 MSI-H cancer patients were available. Mean age at diagnosis of first malignancy was 52.3 years. Eight patients (11% had more than four malignancies each. Most patients (76% had colorectal cancer (CRC. Seventeen patients (23% had only extracolonic malignancies. Eighteen women (36% had gynecological malignancy. Nine women (18% had breast cancer. Mean follow-up was 8.5 years. Five-year overall survival and disease-free survival of all MSI-H cancer patients from first malignancy were 86% and 74.6%, respectively. Five-year overall survival rates of stage 2, 3, and 4 MSI-H CRC patients were 89.5%, 58.4%, and 22.9%, respectively.Conclusion: Although the overall prognosis of MSI-H cancer patients is favorable, this advantage may not be maintained in advanced MSI-H CRC patients. Keywords: microsatellite instability, malignancy, treatment, outcome

  19. Cross-sectional point prevalence survey to study the environmental contamination of nosocomial pathogens in intensive care units under real-life conditions.

    Science.gov (United States)

    Wille, I; Mayr, A; Kreidl, P; Brühwasser, C; Hinterberger, G; Fritz, A; Posch, W; Fuchs, S; Obwegeser, A; Orth-Höller, D; Lass-Flörl, C

    2018-01-01

    In intensive care units (ICUs), inanimate surfaces and equipment may be contaminated by nosocomial pathogens, including multi-drug-resistant micro-organisms. To assess the degree of environmental contamination close to and distant from patients, and contamination of healthcare workers' (HCWs) hands with nosocomial pathogens under real-life conditions and to investigate potential transmission events. Over the course of three weeks, agar contact samples were taken close to and distant from patient areas and from HCWs' hands in eight ICUs of a tertiary care hospital in Innsbruck, Austria. Each ICU was visited once without announcement. Species identification and antimicrobial susceptibility testing were performed according to standard methods, and corresponding strains from patient, environment and hand samples were genotyped using pulsed-field gel electrophoresis. Among 523 samples, HCWs' hands were most frequently contaminated with potentially pathogenic bacteria (15.2%), followed by areas close to patients (10.9%) and areas distant from patients (9.1%). Gram-positive bacteria were identified most often (67.8%), with Enterococcus spp. being the most prevalent species (70% vancomycin sensitive and 30% vancomycin resistant) followed by Staphylococcus aureus, of which 64% were classified as meticillin-resistant Staphylococcus aureus. Molecular typing documented identical strains among patient, environment and hand isolates. This study found widespread contamination of the ICU environment with clinically relevant pathogens, including multi-drug-resistant micro-organisms, despite cleaning and disinfection. The bioburden might not be restricted to areas close to patients. The role of extended environmental disinfection of areas distant from patients in order to improve infection prevention needs further discussion. Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  20. The ROME (Retrospective Observational Multicenter study on Eslicarbazepine) study: Efficacy and behavioural effects of Eslicarbazepine acetate as adjunctive therapy for adults with partial onset seizures in real life.

    Science.gov (United States)

    Assenza, G; Mecarelli, O; Lanzone, J; Assenza, F; Tombini, M; Di Lazzaro, V; Pulitano, P

    2018-05-01

    Eslicarbazepine acetate (ESL) is a third-generation member of the dibenzazepine family approved in 2009 by the European Medicines Agency with the indication of adjunctive therapy in adult people with partial-onset seizures (PPOS). We aimed at assessing the ESL impact on seizure frequency and quality of life in PPOS with a particular attention to sleepiness and depression. We evaluated 50 adult PPOS (>18 years; 48 ± 14 years-old; 23 males) treated with adjunctive ESL for ≥2months with a retrospective multi-centric design. Clinical files of the last 2 years were reviewed checking for monthly seizure frequency, treatment retention rate, adverse drug reactions (ADRs), concomitant anti-epileptic drugs and behavioural scales for sleepiness (Stanford Sleepiness Scale, SSS, and Epworth Sleepiness Scale, ESS), depression (Beck Depression Inventory-II, BDI) and overall quality of life (QOLIE-31). At the end of 96 ± 28 days of ESL treatment, the mean seizure reduction was 56%; 60% of patients had seizure reduction above 50%, with a 31% of the whole population becoming seizure free. We reported 16 ADRs with 4 hyponatremia. Retention rate was 76%. Patient reported less sleepiness after ESL (SSS, p = 0.031; ESS, p = 0.0000002). Before ESL, 38% of patients had pathologic BDI scores, which normalized in most of them (73%) after ESL (BDI improvement, p = 0.000012). These scores resulted in an amelioration of quality of life (QOLIE-31, p = 0.000002). ESL is a safe and effective anti-epileptic drug in a real life scenario, with an excellent behavioural profile for the overall quality of life and, in particular, for sleepiness and depression. Copyright © 2018 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  1. 'Doctor' or 'darling'? Decoding the communication partner from ECoG of the anterior temporal lobe during non-experimental, real-life social interaction

    Directory of Open Access Journals (Sweden)

    Johanna eDerix

    2012-09-01

    Full Text Available Human brain processes underlying real-life social interaction in everyday situations have been difficult to study and have, until now, remained largely unknown. Here, we investigated whether electrocorticography (ECoG recorded for pre-neurosurgical diagnostics during the daily hospital life of epilepsy patients could provide a way to elucidate the neural correlates of non-experimental social interaction. We identified time periods in which patients were involved in conversations with either their respective life partners (Condition 1; C1 or attending physicians (Condition 2; C2. These two conditions can be expected to differentially involve subfunctions of social interaction which have been associated with activity in the anterior temporal lobe (ATL, including the temporal poles (TP. Therefore, we specifically focused on ECoG recordings from this brain region and investigated spectral power modulations in the alpha (8-12 Hz and theta (3-5 Hz frequency ranges, which have been previously assumed to play an important role in the processing of social interaction. We hypothesized that brain activity in this region might be sensitive to differences in the two interaction situations and tested whether these differences can be detected by single-trial decoding. Condition-specific effects in both theta and alpha bands were observed: the left and right TP exclusively showed increased power in C1 compared to C2, whereas more posterior parts of the ATL exhibited similar (C1 > C2 and also contrary (C2 > C1 effects. Single-trial decoding accuracies for classification of these effects were highly above chance. Our findings demonstrate that it is possible to study the neural correlates of human social interaction in non-experimental conditions. Decoding the identity of the communication partner and adjusting the speech output accordingly may be useful in the emerging field of brain- machine interfacing for restoration of expressive speech.

  2. Newborn health benefits or financial risk protection? An ethical analysis of a real-life dilemma in a setting without universal health coverage.

    Science.gov (United States)

    Onarheim, Kristine Husøy; Norheim, Ole Frithjof; Miljeteig, Ingrid

    2018-03-30

    High healthcare costs make illness precarious for both patients and their families' economic situation. Despite the recent focus on the interconnection between health and financial risk at the systemic level, the ethical conflict between concerns for potential health benefits and financial risk protection at the household level in a low-income setting is less understood. Using a seven-step ethical analysis, we examine a real-life dilemma faced by families and health workers at the micro level in Ethiopia and analyse the acceptability of limiting treatment for an ill newborn to protect against financial risk. We assess available evidence and ethical issues at stake and discuss the dilemma with respect to three priority setting criteria: health maximisation, priority to the worse-off and financial risk protection. Giving priority to health maximisation and extra priority to the worse-off suggests, in this particular case, that limiting treatment is not acceptable even if the total well-being gain from reduced financial risk is taken into account. Our conclusion depends on the facts of the case and the relative weight assigned to these criteria. However, there are problematic aspects with the premise of this dilemma. The most affected parties-the newborn, family members and health worker-cannot make free choices about whether to limit treatment or not, and we thereby accept deprivations of people's substantive freedoms. In settings where healthcare is financed largely out-of-pocket, families and health workers face tragic trade-offs. As countries move towards universal health coverage, financial risk protection for high-priority services is necessary to promote fairness, improve health and reduce poverty. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  3. Modeling cost-effectiveness and health gains of a "universal" versus "prioritized" hepatitis C virus treatment policy in a real-life cohort.

    Science.gov (United States)

    Kondili, Loreta A; Romano, Federica; Rolli, Francesca Romana; Ruggeri, Matteo; Rosato, Stefano; Brunetto, Maurizia Rossana; Zignego, Anna Linda; Ciancio, Alessia; Di Leo, Alfredo; Raimondo, Giovanni; Ferrari, Carlo; Taliani, Gloria; Borgia, Guglielmo; Santantonio, Teresa Antonia; Blanc, Pierluigi; Gaeta, Giovanni Battista; Gasbarrini, Antonio; Chessa, Luchino; Erne, Elke Maria; Villa, Erica; Ieluzzi, Donatella; Russo, Francesco Paolo; Andreone, Pietro; Vinci, Maria; Coppola, Carmine; Chemello, Liliana; Madonia, Salvatore; Verucchi, Gabriella; Persico, Marcello; Zuin, Massimo; Puoti, Massimo; Alberti, Alfredo; Nardone, Gerardo; Massari, Marco; Montalto, Giuseppe; Foti, Giuseppe; Rumi, Maria Grazia; Quaranta, Maria Giovanna; Cicchetti, Americo; Craxì, Antonio; Vella, Stefano

    2017-12-01

    We evaluated the cost-effectiveness of two alternative direct-acting antiviral (DAA) treatment policies in a real-life cohort of hepatitis C virus-infected patients: policy 1, "universal," treat all patients, regardless of fibrosis stage; policy 2, treat only "prioritized" patients, delay treatment of the remaining patients until reaching stage F3. A liver disease progression Markov model, which used a lifetime horizon and health care system perspective, was applied to the PITER cohort (representative of Italian hepatitis C virus-infected patients in care). Specifically, 8,125 patients naive to DAA treatment, without clinical, sociodemographic, or insurance restrictions, were used to evaluate the policies' cost-effectiveness. The patients' age and fibrosis stage, assumed DAA treatment cost of €15,000/patient, and the Italian liver disease costs were used to evaluate quality-adjusted life-years (QALY) and incremental cost-effectiveness ratios (ICER) of policy 1 versus policy 2. To generalize the results, a European scenario analysis was performed, resampling the study population, using the mean European country-specific health states costs and mean treatment cost of €30,000. For the Italian base-case analysis, the cost-effective ICER obtained using policy 1 was €8,775/QALY. ICERs remained cost-effective in 94%-97% of the 10,000 probabilistic simulations. For the European treatment scenario the ICER obtained using policy 1 was €19,541.75/QALY. ICER was sensitive to variations in DAA costs, in the utility value of patients in fibrosis stages F0-F3 post-sustained virological response, and in the transition probabilities from F0 to F3. The ICERs decrease with decreasing DAA prices, becoming cost-saving for the base price (€15,000) discounts of at least 75% applied in patients with F0-F2 fibrosis. Extending hepatitis C virus treatment to patients in any fibrosis stage improves health outcomes and is cost-effective; cost-effectiveness significantly increases

  4. Real-life efficacy and safety of vildagliptin compared with sulfonylureas as add-on to metformin in patients with type 2 diabetes mellitus in Germany.

    Science.gov (United States)

    Göke, R; Gruenberger, J B; Bader, G; Dworak, M

    2014-05-01

    Metformin is an established first-line treatment for type 2 diabetes mellitus (T2DM) patients, but intensification of oral anti-diabetes therapy is usually required over time. A large observational study of 45,868 T2DM patients in 27 countries (EDGE) was conducted to compare the effectiveness and safety of vildagliptin as add-on therapy to another oral anti-diabetes drug (OAD) vs other dual OAD combinations. This report presents results from a post-hoc analysis of patients in Germany who received vildagliptin or a sulfonylurea (SU) in combination with metformin. Patients inadequately controlled with monotherapy became eligible only after the add-on treatment was finalized. Patients included were assigned to receive either vildagliptin or another OAD (SUs, thiazolidinediones, glinides, α-glucosidase inhibitors, or metformin; DPP-4 inhibitors or glucagon-like peptide-1 [GLP-1] mimetics/analogs were excluded). The primary end-point was the proportion of patients achieving a reduction in HbA1c >0.3% without peripheral edema, hypoglycemia, discontinuation due to gastrointestinal event, or weight gain ≥5%. Of 8887 patients enrolled in Germany, 6439 received vildagliptin and 971 received SUs as add-on to metformin. The primary end-point was reached in 34.9% and 29.6% of patients in the vildagliptin and SU groups, respectively, with an unadjusted odds ratio of 1.27 (95% CI = 1.09, 1.47; p = 0.001). HbA1c decreased in both cohorts from baseline (-0.7% with vildagliptin vs -0.5% with SUs), with a mean between-group difference of -0.2% (95% CI = -0.22, -0.09). The number of hypoglycemic events was 4-fold higher in the SU group than in the vildagliptin group (vildagliptin = 0.11%; SU = 0.41%). In a real-life setting, vildagliptin was associated with a numerically greater reduction in HbA1c, less hypoglycemia, and more patients reaching target HbA1c without hypoglycemia or weight gain compared with SUs. Open-label design and under reporting of adverse

  5. EUREKA study – the evaluation of real-life use of a biophotonic system in chronic wound management: an interim analysis

    Directory of Open Access Journals (Sweden)

    Romanelli M

    2017-12-01

    Full Text Available Marco Romanelli,1 Alberto Piaggesi,2 Giovanni Scapagnini,3 Valentina Dini,1 Agata Janowska,1 Elisabetta Iacopi,2 Carlotta Scarpa,4 Stéphane Fauverghe,5 Franco Bassetto4 1Wound Healing Research Unit, Division of Dermatology, School of Medicine, University of Pisa, Pisa, 2Diabetic Foot Section, Department of Medicine, University of Pisa, Pisa, 3Department of Medicine and Health Sciences, School of Medicine, University of Molise, Campobasso, 4Clinic of Plastic and Reconstructive Surgery, Padova University-Hospital, Padova, Italy; 5KLOX Technologies Inc., Laval, QC, Canada Objective: Interest has grown regarding photobiomodulation (PBM with low-level light therapy, which has been shown to positively affect the stages of the wound healing process. In a real-life context clinical setting, the objective of the EUREKA study was to investigate efficacy, safety, and quality of life associated with the use of a BioPhotonic gel (LumiHeal™ in the treatment of chronic wounds such as venous leg ulcers (VLUs, diabetic foot ulcers (DFUs, and pressure ulcers (PUs. This BioPhotonic gel represents a new, first-in-class emission spectrum of light, including fluorescence, to induce PBM and modulate healing.Design: The multicenter, prospective, interventional, uncontrolled, open-label study enrolled 100 patients in 12 wound centers in Italy. We performed an early interim analysis based on the first 33 subjects (13 VLU, 17 DFU, 3 PU in seven centers who completed the study.Main results: Seventeen patients (52% achieved total wound closure (full re-epithelialization for 2 weeks during the study period. Two patients (6% were considered “almost closed” (decrease of the wound area of more than 90% at study end and three others (9% were considered “ready for skin grafting”. No related serious adverse events were observed, and the compliance was excellent. After the treatment, the average time to “pain-free” was 11.9 days in the VLU group. Quality of life was

  6. Use of fatal real-life crashes to analyze a safe road transport system model, including the road user, the vehicle, and the road.

    Science.gov (United States)

    Stigson, Helena; Krafft, Maria; Tingvall, Claes

    2008-10-01

    To evaluate if the Swedish Road Administration (SRA) model for a safe road transport system, which includes the interaction between the road user, the vehicle, and the road, could be used to classify fatal car crashes according to some safety indicators. Also, to present a development of the model to better identify system weakness. Real-life crashes with a fatal outcome were classified according to the vehicle's safety rating by Euro NCAP (European Road Assessment Programme) and fitment of ESC (Electronic Stability Control). For each crash, the road was also classified according to EuroRAP (European Road Assessment Programme) criteria, and human behavior in terms of speeding, seat belt use, and driving under the influence of alcohol. Each crash was compared with the model criteria, to identify components that might have contributed to fatal outcome. All fatal crashes where a car occupant was killed that occurred in Sweden during 2004 were included: in all, 215 crashes with 248 fatalities. The data were collected from the in-depth fatal crash data of the Swedish Road Administration (SRA). It was possible to classify 93% of the fatal car crashes according to the SRA model. A number of shortcomings in the criteria were identified since the model did not address rear-end or animal collisions or collisions with stationary/parked vehicles or trailers (18 out of 248 cases). Using the further developed model, it was possible to identify that most of the crashes occurred when two or all three components interacted (in 85 of the total 230 cases). Noncompliance with safety criteria for the road user, the vehicle, and the road led to fatal outcome in 43, 27, and 75 cases, respectively. The SRA model was found to be useful for classifying fatal crashes but needs to be further developed to identify how the components interact and thereby identify weaknesses in the road traffic system. This developed model might be a tool to systematically identify which of the components are

  7. Efficacy and safety of leflunomide in patients with rheumatoid arthritis in real-life clinical practice (results of the Russian multicenter surveillance study

    Directory of Open Access Journals (Sweden)

    R.M. Balabanova

    2014-01-01

    Full Text Available Methotrexate or leflunomide is recommended to be used as the first synthetic disease-modifying anti-rheumatic drug to treat rheumatoid arthri- tis (RA. In 2011, ELAFRA (leflunomide, Haupt Pharma Munster GmbH, Germany; license LP-000804 registered October 3, 2011 was cer- tified and approved in Russia. This surveillance study was aimed at assessing the effectiveness and tolerability of ELAFRA in RA patients in real-life clinical practice. Material and Methods. The study involved patients corresponding to the 1987 RA classification criteria, with varying disease duration. The patients were monitored at 33 Russian medical institutions in March–December 2013. According to the drug label, ELAFRA was prescribed at a dose of 10 mg/day during the first 3 days and subsequently at a dose of 20 mg/day. In case of adverse effects (AEs, the daily dose was recommended to be reduced to 10 mg. The patients were examined before the drug was prescribed; as well as 1, 3, 6 months after therapy was started. The number of painful swollen joints and pain intensity according to the Visual Analog Scale (VAS were assessed. The patients were subjected to laboratory exam- ination (blood test; ESR test; C-reactive protein (CRP test. RA activity was determined using the DAS28 index. AEs were identified. The data on 99 patients (87 females and 12 males; mean age: 51.1±11.1 years; mean disease duration 74.9±65.7 months were used for sta- tistical analysis. Disease activity was moderate in 9 patients and high in 90 patients.Results. Six-month therapy with ELAFRA reduced the mean number of swollen joints from 13.7 to 5.1 and the number of painful joints, from 14.9 to 9.5. VAS pain intensity decreased from 62.7 to 29.6 mm; ESR decreased from 38.8 to 22.18 mm/h; SRP, from 24.9 to 13.0. Low and moderate RA activity according to DAS28 and CDAI indices after treatment was observed in 63 and 46 patients, respectively. No serious AEs have been revealed; non-serious AEs were

  8. Learning real-life cognitive abilities in a novel 360°-virtual reality supermarket: a neuropsychological study of healthy participants and patients with epilepsy.

    Science.gov (United States)

    Grewe, Philip; Kohsik, Agnes; Flentge, David; Dyck, Eugen; Botsch, Mario; Winter, York; Markowitsch, Hans J; Bien, Christian G; Piefke, Martina

    2013-04-23

    in the OctaVis will be efficient for the assessment and training of real-life cognitive abilities in healthy subjects and patients with epilepsy. It is most likely that our findings will also apply for patients with cognitive disabilities resulting from other neurological and psychiatric syndromes.

  9. Current real-life use of vasopressors and inotropes in cardiogenic shock - adrenaline use is associated with excess organ injury and mortality.

    Science.gov (United States)

    Tarvasmäki, Tuukka; Lassus, Johan; Varpula, Marjut; Sionis, Alessandro; Sund, Reijo; Køber, Lars; Spinar, Jindrich; Parissis, John; Banaszewski, Marek; Silva Cardoso, Jose; Carubelli, Valentina; Di Somma, Salvatore; Mebazaa, Alexandre; Harjola, Veli-Pekka

    2016-07-04

    Vasopressors and inotropes remain a cornerstone in stabilization of the severely impaired hemodynamics and cardiac output in cardiogenic shock (CS). The aim of this study was to analyze current real-life use of these medications, and their impact on outcome and on changes in cardiac and renal biomarkers over time in CS. The multinational CardShock study prospectively enrolled 219 patients with CS. The use of vasopressors and inotropes was analyzed in relation to the primary outcome, i.e., 90-day mortality, with propensity score methods in 216 patients with follow-up data available. Changes in cardiac and renal biomarkers over time until 96 hours from baseline were analyzed with linear mixed modeling. Patients were 67 (SD 12) years old, 26 % were women, and 28 % had been resuscitated from cardiac arrest prior to inclusion. On average, systolic blood pressure was 78 (14) and mean arterial pressure 57 (11) mmHg at detection of shock. 90-day mortality was 41 %. Vasopressors and/or inotropes were administered to 94 % of patients and initiated principally within the first 24 hours. Noradrenaline and adrenaline were given to 75 % and 21 % of patients, and 30 % received several vasopressors. In multivariable logistic regression, only adrenaline (21 %) was independently associated with increased 90-day mortality (OR 5.2, 95 % CI 1.88, 14.7, p = 0.002). The result was independent of prior cardiac arrest (39 % of patients treated with adrenaline), and the association remained in propensity-score-adjusted analysis among vasopressor-treated patients (OR 3.0, 95 % CI 1.3, 7.2, p = 0.013); this was further confirmed by propensity-score-matched analysis. Adrenaline was also associated, independent of prior cardiac arrest, with marked worsening of cardiac and renal biomarkers during the first days. Dobutamine and levosimendan were the most commonly used inotropes (49 % and 24 %). There were no differences in mortality, whether noradrenaline was combined

  10. Automatic Model-Based Generation of Parameterized Test Cases Using Data Abstraction

    NARCIS (Netherlands)

    Calamé, Jens R.; Ioustinova, Natalia; Romijn, J.M.T.; Smith, G.; van de Pol, Jan Cornelis

    2007-01-01

    Developing test suites is a costly and error-prone process. Model-based test generation tools facilitate this process by automatically generating test cases from system models. The applicability of these tools, however, depends on the size of the target systems. Here, we propose an approach to

  11. Class hierarchical test case generation algorithm based on expanded EMDPN model

    Institute of Scientific and Technical Information of China (English)

    LI Jun-yi; GONG Hong-fang; HU Ji-ping; ZOU Bei-ji; SUN Jia-guang

    2006-01-01

    A new model of event and message driven Petri network(EMDPN) based on the characteristic of class interaction for messages passing between two objects was extended. Using EMDPN interaction graph, a class hierarchical test-case generation algorithm with cooperated paths (copaths) was proposed, which can be used to solve the problems resulting from the class inheritance mechanism encountered in object-oriented software testing such as oracle, message transfer errors, and unreachable statement. Finally, the testing sufficiency was analyzed with the ordered sequence testing criterion(OSC). The results indicate that the test cases stemmed from newly proposed automatic algorithm of copaths generation satisfies synchronization message sequences testing criteria, therefore the proposed new algorithm of copaths generation has a good coverage rate.

  12. GENERATING TEST CASES FOR PLATFORM INDEPENDENT MODEL BY USING USE CASE MODEL

    OpenAIRE

    Hesham A. Hassan,; Zahraa. E. Yousif

    2010-01-01

    Model-based testing refers to testing and test case generation based on a model that describes the behavior of the system. Extensive use of models throughout all the phases of software development starting from the requirement engineering phase has led to increased importance of Model Based Testing. The OMG initiative MDA has revolutionized the way models would be used for software development. Ensuring that all user requirements are addressed in system design and the design is getting suffic...

  13. HYBRID DATA APPROACH FOR SELECTING EFFECTIVE TEST CASES DURING THE REGRESSION TESTING

    OpenAIRE

    Mohan, M.; Shrimali, Tarun

    2017-01-01

    In the software industry, software testing becomes more important in the entire software development life cycle. Software testing is one of the fundamental components of software quality assurances. Software Testing Life Cycle (STLC)is a process involved in testing the complete software, which includes Regression Testing, Unit Testing, Smoke Testing, Integration Testing, Interface Testing, System Testing & etc. In the STLC of Regression testing, test case selection is one of the most importan...

  14. Automating Test Activities: Test Cases Creation, Test Execution, and Test Reporting with Multiple Test Automation Tools

    OpenAIRE

    Loke Mun Sei

    2015-01-01

    Software testing has become a mandatory process in assuring the software product quality. Hence, test management is needed in order to manage the test activities conducted in the software test life cycle. This paper discusses on the challenges faced in the software test life cycle, and how the test processes and test activities, mainly on test cases creation, test execution, and test reporting is being managed and automated using several test automation tools, i.e. Jira, ...

  15. Analysis of the imbalance price scheme in the Spanish electricity market: A wind power test case

    International Nuclear Information System (INIS)

    Bueno-Lorenzo, Miriam; Moreno, M. Ángeles; Usaola, Julio

    2013-01-01

    This work investigates the interaction between wind power and electricity markets. The paper is focused on balancing markets pricing policies. The proposal of a new imbalance price scheme is included and conveniently evaluated. This proposed scheme tries to minimise the use of ancillary services to compensate for deviations in searching for a more efficient market design. The effectiveness of imbalance prices as market signals is also examined, and policy recommendations regarding imbalance services are discussed. Two test cases are included that analyse the participation of a wind power producer in the Spanish electricity market using a stochastic optimisation strategy. For this purpose, the uncertainty of the variables is considered, i.e., wind power production and prediction, intraday and imbalance prices. Test cases were run with real data for 10 months, and realistic results are presented along with a hypothetical test case. The regulation of the imbalance prices may not be adequate for the Spanish electricity market because an error drop is not sufficiently encouraged. Therefore, we suggest the application of a new imbalance price scheme, which includes an additional constraint. The conclusions of this paper can be assumed to be general policy recommendations

  16. Mathematical Basis and Test Cases for Colloid-Facilitated Radionuclide Transport Modeling in GDSA-PFLOTRAN

    Energy Technology Data Exchange (ETDEWEB)

    Reimus, Paul William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-07-31

    This report provides documentation of the mathematical basis for a colloid-facilitated radionuclide transport modeling capability that can be incorporated into GDSA-PFLOTRAN. It also provides numerous test cases against which the modeling capability can be benchmarked once the model is implemented numerically in GDSA-PFLOTRAN. The test cases were run using a 1-D numerical model developed by the author, and the inputs and outputs from the 1-D model are provided in an electronic spreadsheet supplement to this report so that all cases can be reproduced in GDSA-PFLOTRAN, and the outputs can be directly compared with the 1-D model. The cases include examples of all potential scenarios in which colloid-facilitated transport could result in the accelerated transport of a radionuclide relative to its transport in the absence of colloids. Although it cannot be claimed that all the model features that are described in the mathematical basis were rigorously exercised in the test cases, the goal was to test the features that matter the most for colloid-facilitated transport; i.e., slow desorption of radionuclides from colloids, slow filtration of colloids, and equilibrium radionuclide partitioning to colloids that is strongly favored over partitioning to immobile surfaces, resulting in a substantial fraction of radionuclide mass being associated with mobile colloids.

  17. Non-pathological complete paternal uniparental isodisomy of chromosome 2 revealed in a maternity testing case.

    Science.gov (United States)

    Chen, Man; Jiang, Jian; Li, Chen; Ren, He; Chen, Wei; Liu, Zhiyong; Cheng, Feng; Zhao, Jing; Chen, Tong; Chen, Chuguang; Yan, Jiangwei

    2018-05-25

    We present a duo paternity test case to assess the biological relationship between a woman and her female child. After analyzing 57 autosomal and 19 X-chromosomal short tandem repeat loci, mother-daughter exclusions were discovered at four loci, which were all located on chromosome 2. Further testing of whole-genome single nucleotide polymorphisms confirmed that the daughter had complete uniparental disomy (UPD) of chromosome 2. This study presents a cautionary case demonstrating that hasty decisions of parentage exclusion should not be made when genetic markers on the same chromosome do not conform to Mendel's laws due to UPD.

  18. The role of Metals in Amyloid Aggregation: A Test Case for ab initio Simulations

    International Nuclear Information System (INIS)

    Minicozzi, V.; Rossi, G. C.; Stellato, F.; Morante, S.

    2007-01-01

    First principle ab initio molecular dynamics simulations of the Car-Parrinello type have proved to be of invaluable help in understanding the microscopic mechanisms of chemical bonding both in solid state physics and in structural biophysics. In this work we present as test cases the study of the Cu coordination mode in two especially important examples: Prion protein and β-amyloids. Using medium size PC-clusters as well as larger parallel platforms, we are able to deal with systems comprising 300 to 500 atoms and 1000 to 1500 electrons for as long as 2-3 ps. We present structural results which confirm indications coming from NMR and XAS data

  19. Simulation of VVER MCCI reactor test case with ASTEC V2/MEDICIS computer code

    International Nuclear Information System (INIS)

    Stefanova, A.; Grudev, P.; Gencheva, R.

    2011-01-01

    This paper presents an application of the ASTEC v2, module MEDICIS for simulation of VVER Molten core concrete interaction test (MCCI) case without water injection. The main purpose of performed calculation is verification and improvement of module MEDICIS/ASTECv2 for better simulation of core concrete interaction processes. The VVER-1000 reference nuclear power plant was chosen as SARNET2 benchmark MCCI test-case. The initial conditions for MCCI test are taken after SBO scenario calculated with ASTEC version 1.3R2 by INRNE. (authors)

  20. Seismic waveform inversion best practices: regional, global and exploration test cases

    Science.gov (United States)

    Modrak, Ryan; Tromp, Jeroen

    2016-09-01

    Reaching the global minimum of a waveform misfit function requires careful choices about the nonlinear optimization, preconditioning and regularization methods underlying an inversion. Because waveform inversion problems are susceptible to erratic convergence associated with strong nonlinearity, one or two test cases are not enough to reliably inform such decisions. We identify best practices, instead, using four seismic near-surface problems, one regional problem and two global problems. To make meaningful quantitative comparisons between methods, we carry out hundreds of inversions, varying one aspect of the implementation at a time. Comparing nonlinear optimization algorithms, we find that limited-memory BFGS provides computational savings over nonlinear conjugate gradient methods in a wide range of test cases. Comparing preconditioners, we show that a new diagonal scaling derived from the adjoint of the forward operator provides better performance than two conventional preconditioning schemes. Comparing regularization strategies, we find that projection, convolution, Tikhonov regularization and total variation regularization are effective in different contexts. Besides questions of one strategy or another, reliability and efficiency in waveform inversion depend on close numerical attention and care. Implementation details involving the line search and restart conditions have a strong effect on computational cost, regardless of the chosen nonlinear optimization algorithm.

  1. Automatic WSDL-guided Test Case Generation for PropEr Testing of Web Services

    Directory of Open Access Journals (Sweden)

    Konstantinos Sagonas

    2012-10-01

    Full Text Available With web services already being key ingredients of modern web systems, automatic and easy-to-use but at the same time powerful and expressive testing frameworks for web services are increasingly important. Our work aims at fully automatic testing of web services: ideally the user only specifies properties that the web service is expected to satisfy, in the form of input-output relations, and the system handles all the rest. In this paper we present in detail the component which lies at the heart of this system: how the WSDL specification of a web service is used to automatically create test case generators that can be fed to PropEr, a property-based testing tool, to create structurally valid random test cases for its operations and check its responses. Although the process is fully automatic, our tool optionally allows the user to easily modify its output to either add semantic information to the generators or write properties that test for more involved functionality of the web services.

  2. A Method to Select Software Test Cases in Consideration of Past Input Sequence

    International Nuclear Information System (INIS)

    Kim, Hee Eun; Kim, Bo Gyung; Kang, Hyun Gook

    2015-01-01

    In the Korea Nuclear I and C Systems (KNICS) project, the software for the fully-digitalized reactor protection system (RPS) was developed under a strict procedure. Even though the behavior of the software is deterministic, the randomness of input sequence produces probabilistic behavior of software. A software failure occurs when some inputs to the software occur and interact with the internal state of the digital system to trigger a fault that was introduced into the software during the software lifecycle. In this paper, the method to select test set for software failure probability estimation is suggested. This test set reflects past input sequence of software, which covers all possible cases. In this study, the method to select test cases for software failure probability quantification was suggested. To obtain profile of paired state variables, relationships of the variables need to be considered. The effect of input from human operator also have to be considered. As an example, test set of PZR-PR-Lo-Trip logic was examined. This method provides framework for selecting test cases of safety-critical software

  3. Test case specifications for coupled neutronics-thermal hydraulics calculation of Gas-cooled Fast Reactor

    Science.gov (United States)

    Osuský, F.; Bahdanovich, R.; Farkas, G.; Haščík, J.; Tikhomirov, G. V.

    2017-01-01

    The paper is focused on development of the coupled neutronics-thermal hydraulics model for the Gas-cooled Fast Reactor. It is necessary to carefully investigate coupled calculations of new concepts to avoid recriticality scenarios, as it is not possible to ensure sub-critical state for a fast reactor core under core disruptive accident conditions. Above mentioned calculations are also very suitable for development of new passive or inherent safety systems that can mitigate the occurrence of the recriticality scenarios. In the paper, the most promising fuel material compositions together with a geometry model are described for the Gas-cooled fast reactor. Seven fuel pin and fuel assembly geometry is proposed as a test case for coupled calculation with three different enrichments of fissile material in the form of Pu-UC. The reflective boundary condition is used in radial directions of the test case and vacuum boundary condition is used in axial directions. During these condition, the nuclear system is in super-critical state and to achieve a stable state (which is numerical representation of operational conditions) it is necessary to decrease the reactivity of the system. The iteration scheme is proposed, where SCALE code system is used for collapsing of a macroscopic cross-section into few group representation as input for coupled code NESTLE.

  4. Cavitating Propeller Performance in Inclined Shaft Conditions with OpenFOAM: PPTC 2015 Test Case

    Science.gov (United States)

    Gaggero, Stefano; Villa, Diego

    2018-05-01

    In this paper, we present our analysis of the non-cavitating and cavitating unsteady performances of the Potsdam Propeller Test Case (PPTC) in oblique flow. For our calculations, we used the Reynolds-averaged Navier-Stokes equation (RANSE) solver from the open-source OpenFOAM libraries. We selected the homogeneous mixture approach to solve for multiphase flow with phase change, using the volume of fluid (VoF) approach to solve the multiphase flow and modeling the mass transfer between vapor and water with the Schnerr-Sauer model. Comparing the model results with the experimental measurements collected during the Second Workshop on Cavitation and Propeller Performance - SMP'15 enabled our assessment of the reliability of the open-source calculations. Comparisons with the numerical data collected during the workshop enabled further analysis of the reliability of different flow solvers from which we produced an overview of recommended guidelines (mesh arrangements and solver setups) for accurate numerical prediction even in off-design conditions. Lastly, we propose a number of calculations using the boundary element method developed at the University of Genoa for assessing the reliability of this dated but still widely adopted approach for design and optimization in the preliminary stages of very demanding test cases.

  5. Idealized tropical cyclone simulations of intermediate complexity: A test case for AGCMs

    Directory of Open Access Journals (Sweden)

    Kevin Reed

    2012-04-01

    Full Text Available The paper introduces a moist, deterministic test case of intermediate complexity for Atmospheric General Circulation Models (AGCMs. We suggest pairing an AGCM dynamical core with simple physical parameterizations to test the evolution of a single, idealized, initially weak vortex into a tropical cyclone. The initial conditions are based on an initial vortex seed that is in gradient-wind and hydrostatic balance. The suggested ``simple-physics'' package consists of parameterizations of bulk aerodynamic surface fluxes for moisture, sensible heat and momentum, boundary layer diffusion, and large-scale condensation. Such a configuration includes the important driving mechanisms for tropical cyclones, and leads to a rapid intensification of the initial vortex over a forecast period of ten days. The simple-physics test paradigm is not limited to tropical cyclones, and can be universally applied to other flow fields. The physical parameterizations are described in detail to foster model intercomparisons.The characteristics of the intermediate-complexity test case are demonstrated with the help of four hydrostatic dynamical cores that are part of the Community Atmosphere Model version 5 (CAM 5 developed at the National Center for Atmospheric Research (NCAR. In particular, these are the Finite-Volume, Spectral Element, and spectral transform Eulerian and semi-Lagrangian dynamical cores that are coupled to the simple-physics suite. The simulations show that despite the simplicity of the physics forcings the models develop the tropical cyclone at horizontal grid spacings of about 55 km and finer. The simple-physics simulations reveal essential differences in the storm's structure and strength due to the choice of the dynamical core. Similar differences are also seen in complex full-physics aqua-planet experiments with CAM 5 which serve as a motivator for this work. The results suggest that differences in complex full-physics simulations can be, at least

  6. Rationale and design of the PREDICE project: cost-effectiveness of type 2 diabetes prevention among high-risk Spanish individuals following lifestyle intervention in real-life primary care setting.

    Science.gov (United States)

    Costa, Bernardo; Cabré, Joan J; Sagarra, Ramon; Solà-Morales, Oriol; Barrio, Francisco; Piñol, Josep L; Cos, Xavier; Bolíbar, Bonaventura; Castell, Conxa; Kissimova-Skarbek, Katarzyna; Tuomilehto, Jaakko

    2011-08-04

    Type 2 diabetes is an important preventable disease and a growing public health problem. Based on information provided by clinical trials, we know that Type 2 diabetes can be prevented or delayed by lifestyle intervention. In view of translating the findings of diabetes prevention research into real-life it is necessary to carry out community-based evaluations so as to learn about the feasibility and effectiveness of locally designed and implemented programmes. The aim of this project was to assess the effectiveness of an active real-life primary care strategy in high-risk individuals for developing diabetes, and then evaluate its efficiency. Cost-Effectiveness analysis of the DE-PLAN (Diabetes in Europe - Prevention using Lifestyle, physical Activity and Nutritional intervention) project when applied to a Mediterranean population in Catalonia (DE-PLAN-CAT). Multicenter, longitudinal cohort assessment (4 years) conducted in 18 primary health-care centres (Catalan Health Institute). Individuals without diabetes aged 45-75 years were screened using the Finnish Diabetes Risk Score - FINDRISC - questionnaire and a 2-h oral glucose tolerance test. All high risk tested individuals were invited to participate in either a usual care intervention (information on diet and cardiovascular health without individualized programme), or the intensive DE-PLAN educational program (individualized or group) periodically reinforced. Oral glucose tolerance test was repeated yearly to determine diabetes incidence. Besides measuring the accumulated incidence of diabetes, information was collected on economic impact of the interventions in both cohorts (using direct and indirect cost questionnaires) and information on utility measures (Quality Adjusted Life Years). A cost-utility and a cost-effectiveness analysis will be performed and data will be modelled to predict long-term cost-effectiveness. The project was intended to evidence that a substantial reduction in Type 2 diabetes incidence

  7. Real-Time Extended Interface Automata for Software Testing Cases Generation

    Directory of Open Access Journals (Sweden)

    Shunkun Yang

    2014-01-01

    Full Text Available Testing and verification of the interface between software components are particularly important due to the large number of complex interactions, which requires the traditional modeling languages to overcome the existing shortcomings in the aspects of temporal information description and software testing input controlling. This paper presents the real-time extended interface automata (RTEIA which adds clearer and more detailed temporal information description by the application of time words. We also establish the input interface automaton for every input in order to solve the problems of input controlling and interface covering nimbly when applied in the software testing field. Detailed definitions of the RTEIA and the testing cases generation algorithm are provided in this paper. The feasibility and efficiency of this method have been verified in the testing of one real aircraft braking system.

  8. Real-Time Extended Interface Automata for Software Testing Cases Generation

    Science.gov (United States)

    Yang, Shunkun; Xu, Jiaqi; Man, Tianlong; Liu, Bin

    2014-01-01

    Testing and verification of the interface between software components are particularly important due to the large number of complex interactions, which requires the traditional modeling languages to overcome the existing shortcomings in the aspects of temporal information description and software testing input controlling. This paper presents the real-time extended interface automata (RTEIA) which adds clearer and more detailed temporal information description by the application of time words. We also establish the input interface automaton for every input in order to solve the problems of input controlling and interface covering nimbly when applied in the software testing field. Detailed definitions of the RTEIA and the testing cases generation algorithm are provided in this paper. The feasibility and efficiency of this method have been verified in the testing of one real aircraft braking system. PMID:24892080

  9. A Multi-Process Test Case to Perform Comparative Analysis of Coastal Oceanic Models

    Science.gov (United States)

    Lemarié, F.; Burchard, H.; Knut, K.; Debreu, L.

    2016-12-01

    Due to the wide variety of choices that need to be made during the development of dynamical kernels of oceanic models, there is a strong need for an effective and objective assessment of the various methods and approaches that predominate in the community. We present here an idealized multi-scale scenario for coastal ocean models combining estuarine, coastal and shelf sea scales at midlatitude. The bathymetry, initial conditions and external forcings are defined analytically so that any model developer or user could reproduce the test case with its own numerical code. Thermally stratified conditions are prescribed and a tidal forcing is imposed as a propagating coastal Kelvin wave. The following physical processes can be assessed from the model results: estuarine process driven by tides and buoyancy gradients, the river plume dynamics, tidal fronts, and the interaction between tides and inertial oscillations. We show results obtained using the GETM (General Estuarine Transport Model) and the CROCO (Coastal and Regional Ocean Community model) models. Those two models are representative of the diversity of numerical methods in use in coastal models: GETM is based on a quasi-lagrangian vertical coordinate, a coupled space-time approach for advective terms, a TVD (Total Variation Diminishing) tracer advection scheme while CROCO is discretized with a quasi-eulerian vertical coordinate, a method of lines is used for advective terms, and tracer advection satisfies the TVB (Total Variation Bounded) property. The multiple scales are properly resolved thanks to nesting strategies, 1-way nesting for GETM and 2-way nesting for CROCO. Such test case can be an interesting experiment to continue research in numerical approaches as well as an efficient tool to allow intercomparison between structured-grid and unstructured-grid approaches. Reference : Burchard, H., Debreu, L., Klingbeil, K., Lemarié, F. : The numerics of hydrostatic structured-grid coastal ocean models: state of

  10. IPRT polarized radiative transfer model intercomparison project - Three-dimensional test cases (phase B)

    Science.gov (United States)

    Emde, Claudia; Barlakas, Vasileios; Cornet, Céline; Evans, Frank; Wang, Zhen; Labonotte, Laurent C.; Macke, Andreas; Mayer, Bernhard; Wendisch, Manfred

    2018-04-01

    Initially unpolarized solar radiation becomes polarized by scattering in the Earth's atmosphere. In particular molecular scattering (Rayleigh scattering) polarizes electromagnetic radiation, but also scattering of radiation at aerosols, cloud droplets (Mie scattering) and ice crystals polarizes. Each atmospheric constituent produces a characteristic polarization signal, thus spectro-polarimetric measurements are frequently employed for remote sensing of aerosol and cloud properties. Retrieval algorithms require efficient radiative transfer models. Usually, these apply the plane-parallel approximation (PPA), assuming that the atmosphere consists of horizontally homogeneous layers. This allows to solve the vector radiative transfer equation (VRTE) efficiently. For remote sensing applications, the radiance is considered constant over the instantaneous field-of-view of the instrument and each sensor element is treated independently in plane-parallel approximation, neglecting horizontal radiation transport between adjacent pixels (Independent Pixel Approximation, IPA). In order to estimate the errors due to the IPA approximation, three-dimensional (3D) vector radiative transfer models are required. So far, only a few such models exist. Therefore, the International Polarized Radiative Transfer (IPRT) working group of the International Radiation Commission (IRC) has initiated a model intercomparison project in order to provide benchmark results for polarized radiative transfer. The group has already performed an intercomparison for one-dimensional (1D) multi-layer test cases [phase A, 1]. This paper presents the continuation of the intercomparison project (phase B) for 2D and 3D test cases: a step cloud, a cubic cloud, and a more realistic scenario including a 3D cloud field generated by a Large Eddy Simulation (LES) model and typical background aerosols. The commonly established benchmark results for 3D polarized radiative transfer are available at the IPRT website (http

  11. Asthma control in patients receiving inhaled corticosteroid and long-acting beta2-agonist fixed combinations. A real-life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation

    Directory of Open Access Journals (Sweden)

    Nicolini Gabriele

    2011-07-01

    Full Text Available Abstract Background Although patients have more problems using metered dose inhalers, clinical comparisons suggest they provide similar control to dry powder inhalers. Using real-life situations this study was designed to evaluate asthma control in outpatients with moderate to severe persistent asthma and to compare efficacy of fixed combinations of inhaled corticosteroids (ICS and long acting beta-agonists (LABA. Methods This real-life study had a cross-sectional design. Patients using fixed combinations of ICS and LABA had their asthma control and spirometry assessed during regular visits. Results 111 patients were analyzed: 53 (47.7% received maintenance therapy of extrafine beclomethasone-formoterol (BDP/F pressurized metered dose inhaler (pMDI, 25 (22.5% fluticasone-salmeterol (FP/S dry powder inhaler (DPI, and 33 (29.7% budesonide-formoterol (BUD/F DPI. Severity of asthma at time of diagnosis, assessed by the treating physician, was comparable among groups. Asthma control was achieved by 45.9% of patients; 38.7% were partially controlled and 15.3% were uncontrolled. In the extrafine BDF/F group, asthma control total score, daytime symptom score and rescue medication use score were significantly better than those using fixed DPI combinations (5.8 ± 6.2 vs. 8.5 ± 6.8; 1.4 ± 1.8 vs. 2.3 ± 2.1; 1.8 ± 2.2 vs. 2.6 ± 2.2; p = 0.0160; p = 0.012 and p = 0.025, respectively and the mean daily ICS dose were significantly lower. Conclusions pMDI extrafine BDP/F combination demonstrated better asthma control compared to DPIs formulated with larger particles. This could be due to the improved lung deposition of the dose or less reliance on the optimal inhalation technique or both.

  12. Retention, dosing, tolerability and patient reported seizure outcome of Zonisamide as only add-on treatment under real-life conditions in adult patients with partial onset seizures: Results of the observational study ZOOM.

    Science.gov (United States)

    Hamer, Hajo; Baulac, Michel; McMurray, Rob; Kockelmann, Edgar

    2016-01-01

    Zonisamide is licensed for adjunctive therapy for partial-onset seizures with or without secondary generalisation in patients 6 years and older and as monotherapy for the treatment of partial seizures in adult patients with newly diagnosed epilepsy, and shows a favourable pharmacokinetic profile with low interaction potential with other drugs. The aim of the present study was to gather real-life data on retention and modalities of zonisamide use when administered as only add-on treatment to a current AED monotherapy in adult patients with partial-onset seizures. This multicenter observational study was performed in 4 European countries and comprised three visits: baseline, and after 3 and 6 months. Data on patients' retention, reported efficacy, tolerability and safety, and quality of life was collected. Of 100 included patients, 93 could be evaluated. After 6 months, the retention rate of zonisamide add-on therapy was 82.8%. At this time, a reduction of seizure frequency of at least 50% was observed in 79.7% of patients, with 43.6% reporting seizure freedom over the last 3 months of the study period. Adverse events were reported by 19.4% of patients, with fatigue, agitation, dizziness, and headache being most frequent. Approximately 25% of patients were older than 60 years, many of whom suffered from late-onset epilepsy. Compared to younger patients, these patients showed considerable differences with regard to their antiepileptic drug regimen at baseline, and slightly higher responder and retention rates at 6 months. Despite limitations due to the non-interventional open-label design and the low sample size, the results show that zonisamide as only add-on therapy is well retained, indicating effectiveness in the majority of patients under real-life conditions. Copyright © 2015. Published by Elsevier Ltd.

  13. A test case of the deformation rate analysis (DRA) stress measurement method

    Energy Technology Data Exchange (ETDEWEB)

    Dight, P.; Hsieh, A. [Australian Centre for Geomechanics, Univ. of WA, Crawley (Australia); Johansson, E. [Saanio and Riekkola Oy, Helsinki (Finland); Hudson, J.A. [Rock Engineering Consultants (United Kingdom); Kemppainen, K.

    2012-01-15

    As part of Posiva's site and ONKALO investigations, the in situ rock stress has been measured by a variety of techniques, including hydraulic fracturing, overcoring, and convergence measurements. All these techniques involve direct measurements in a drillhole or at the rock surface. An alternative method is to test drillhole core in a way that enables estimation of the magnitudes and orientations of the in situ rock stress. The Kaiser Effect (KE) and Deformation Rate Analysis (DRA) are two ways to do this. In the work reported here, a 'blind' DRA test was conducted on core obtained from the POSE (Posiva's Olkiluoto Spalling Experiment) niche in the ONKALO. The term 'blind' means that the two first authors of this report, who conducted the tests at the Australian Centre for Geomechanics, did not know the depths below surface at which the cores had been obtained. The results of this DRA Test Case are presented, together with an explanation of the DRA procedure. Also, additional information that would help in such DRA testing and associated analysis is explained. One of the problems in comparing the DRA results with the known Olkiluoto stress field is that the latter is highly variable across the site, as experienced by the previous in situ stress measurements and as predicted by numerical analysis. The variability is mainly caused by the presence of the large brittle deformation zones which perturb the local stress state. However, this variability reduces with depth and the stress field becomes more stable at the {approx} 350 m at which the drillhole cores were obtained. Another compounding difficulty is that the stress quantity, being a second order tensor, requires six independent components for its specification. In other words, comparison of the DRA results and the known stress field requires comparison of six different quantities. In terms of the major principal stress orientation, the DRA results predict an orientation completely

  14. A test case of the deformation rate analysis (DRA) stress measurement method

    International Nuclear Information System (INIS)

    Dight, P.; Hsieh, A.; Johansson, E.; Hudson, J.A.; Kemppainen, K.

    2012-01-01

    As part of Posiva's site and ONKALO investigations, the in situ rock stress has been measured by a variety of techniques, including hydraulic fracturing, overcoring, and convergence measurements. All these techniques involve direct measurements in a drillhole or at the rock surface. An alternative method is to test drillhole core in a way that enables estimation of the magnitudes and orientations of the in situ rock stress. The Kaiser Effect (KE) and Deformation Rate Analysis (DRA) are two ways to do this. In the work reported here, a 'blind' DRA test was conducted on core obtained from the POSE (Posiva's Olkiluoto Spalling Experiment) niche in the ONKALO. The term 'blind' means that the two first authors of this report, who conducted the tests at the Australian Centre for Geomechanics, did not know the depths below surface at which the cores had been obtained. The results of this DRA Test Case are presented, together with an explanation of the DRA procedure. Also, additional information that would help in such DRA testing and associated analysis is explained. One of the problems in comparing the DRA results with the known Olkiluoto stress field is that the latter is highly variable across the site, as experienced by the previous in situ stress measurements and as predicted by numerical analysis. The variability is mainly caused by the presence of the large brittle deformation zones which perturb the local stress state. However, this variability reduces with depth and the stress field becomes more stable at the ∼ 350 m at which the drillhole cores were obtained. Another compounding difficulty is that the stress quantity, being a second order tensor, requires six independent components for its specification. In other words, comparison of the DRA results and the known stress field requires comparison of six different quantities. In terms of the major principal stress orientation, the DRA results predict an orientation completely different to the NW-SE regional

  15. A test case of computer aided motion planning for nuclear maintenance operation

    Energy Technology Data Exchange (ETDEWEB)

    Schmitzberger, E.; Bouchet, J.L. [Electricite de France (EDF), Dept. Surveillance Diagnostic Maintenance, 78 - Chatou (France); Schmitzberger, E. [Institut National Polytechnique, CRAN, 54 - Vandoeuvre les Nancy (France)

    2001-07-01

    Needs for improved tools for nuclear power plant maintenance preparation are expressed by EDF engineering. These are an easier and better management of logistics constraints such as free spaces for motions or handling tasks. The lack of generic or well suited tools and the specificity of nuclear maintenance operation have led EDF R and D to develop its own motion planning tools in collaboration with LAAS-CNRS, Utrecht University and the software publisher CADCENTRE within the framework of the three years Esprit LTR project MOLOG. EDF users needs will be summed up in the first part of the paper under the title ''Motion feasibility studies for maintenance operation'' and then compared to the current industrial offer in the ''Software's background'''s part. The definition and objectives ''Towards motion planning tools'' follows. It explains why maintenance preparation pertains to automatic motion planning and how it makes studies much simpler. The ''MOLOG's Benchmark and first result'''s part describes the test-case used to evaluate the MOLOG project and gives an outlook at the results obtained so far. (author)

  16. Water and Sediment Output Evaluation Using Cellular Automata on Alpine Catchment: Soana, Italy - Test Case

    Science.gov (United States)

    Pasculli, Antonio; Audisio, Chiara; Sciarra, Nicola

    2017-12-01

    In the alpine contest, the estimation of the rainfall (inflow) and the discharge (outflow) data are very important in order to, at least, analyse historical time series at catchment scale; determine the hydrological maximum and minimum estimate flood and drought frequency. Hydrological researches become a precious source of information for various human activities, in particular for land use management and planning. Many rainfall- runoff models have been proposed to reflect steady, gradually-varied flow condition inside a catchment. In these last years, the application of Reduced Complexity Models (RCM) has been representing an excellent alternative resource for evaluating the hydrological response of catchments, within a period of time up to decades. Hence, this paper is aimed at the discussion of the application of the research code CAESAR, based on cellular automaton (CA) approach, in order to evaluate the water and the sediment outputs from an alpine catchment (Soana, Italy), selected as test case. The comparison between the predicted numerical results, developed through parametric analysis, and the available measured data are discussed. Finally, the analysis of a numerical estimate of the sediment budget over ten years is presented. The necessity of a fast, but reliable numerical support when the measured data are not so easily accessible, as in Alpine catchments, is highlighted.

  17. Development of a codon optimization strategy using the efor RED reporter gene as a test case

    Science.gov (United States)

    Yip, Chee-Hoo; Yarkoni, Orr; Ajioka, James; Wan, Kiew-Lian; Nathan, Sheila

    2018-04-01

    Synthetic biology is a platform that enables high-level synthesis of useful products such as pharmaceutically related drugs, bioplastics and green fuels from synthetic DNA constructs. Large-scale expression of these products can be achieved in an industrial compliant host such as Escherichia coli. To maximise the production of recombinant proteins in a heterologous host, the genes of interest are usually codon optimized based on the codon usage of the host. However, the bioinformatics freeware available for standard codon optimization might not be ideal in determining the best sequence for the synthesis of synthetic DNA. Synthesis of incorrect sequences can prove to be a costly error and to avoid this, a codon optimization strategy was developed based on the E. coli codon usage using the efor RED reporter gene as a test case. This strategy replaces codons encoding for serine, leucine, proline and threonine with the most frequently used codons in E. coli. Furthermore, codons encoding for valine and glycine are substituted with the second highly used codons in E. coli. Both the optimized and original efor RED genes were ligated to the pJS209 plasmid backbone using Gibson Assembly and the recombinant DNAs were transformed into E. coli E. cloni 10G strain. The fluorescence intensity per cell density of the optimized sequence was improved by 20% compared to the original sequence. Hence, the developed codon optimization strategy is proposed when designing an optimal sequence for heterologous protein production in E. coli.

  18. A test case of computer aided motion planning for nuclear maintenance operation

    International Nuclear Information System (INIS)

    Schmitzberger, E.; Bouchet, J.L.; Schmitzberger, E.

    2001-01-01

    Needs for improved tools for nuclear power plant maintenance preparation are expressed by EDF engineering. These are an easier and better management of logistics constraints such as free spaces for motions or handling tasks. The lack of generic or well suited tools and the specificity of nuclear maintenance operation have led EDF R and D to develop its own motion planning tools in collaboration with LAAS-CNRS, Utrecht University and the software publisher CADCENTRE within the framework of the three years Esprit LTR project MOLOG. EDF users needs will be summed up in the first part of the paper under the title ''Motion feasibility studies for maintenance operation'' and then compared to the current industrial offer in the ''Software's background'''s part. The definition and objectives ''Towards motion planning tools'' follows. It explains why maintenance preparation pertains to automatic motion planning and how it makes studies much simpler. The ''MOLOG's Benchmark and first result'''s part describes the test-case used to evaluate the MOLOG project and gives an outlook at the results obtained so far. (author)

  19. The feasibility of ambitious climate agreements. Norway as an early test case

    Energy Technology Data Exchange (ETDEWEB)

    Andresen, Steinar; Kolshus, Hans H.; Torvanger, Asbjoern

    2002-09-01

    There are considerable differences between developed countries as to how difficult it will be to meet their commitments under the Kyoto Protocol. 'High-cost abatement countries' are particularly interesting as they can be seen as 'test-cases' for other nations in more ambitious climate policy agreements. We assume that a country's objective is to develop an efficient climate policy, achieving cost effectiveness and environmental effectiveness, and that also is politically feasible. Norway is among the countries that will have a hard time in meeting their obligations. Our study suggests that Norway's climate policy has emphasized an international approach, whereas the domestic performance on cost effectiveness has been more moderate. An obvious reason for this is the lower cost associated with the international approach. A 'political cost' associated with such a policy can be criticism from environmental NGOs and other countries. At least in the near term there is little reason to expect 'climate enthusiasm' from the public or many countries of the world. Therefore, just like Norway, they will want emissions reductions carried out as cheaply as possible, which could imply extensive international quota trading, whereas compromises with regard to cost effectiveness are struck at the domestic scene for political feasibility reasons. (author)

  20. Using a fuzzy comprehensive evaluation method to determine product usability: A test case.

    Science.gov (United States)

    Zhou, Ronggang; Chan, Alan H S

    2017-01-01

    In order to take into account the inherent uncertainties during product usability evaluation, Zhou and Chan [1] proposed a comprehensive method of usability evaluation for products by combining the analytic hierarchy process (AHP) and fuzzy evaluation methods for synthesizing performance data and subjective response data. This method was designed to provide an integrated framework combining the inevitable vague judgments from the multiple stages of the product evaluation process. In order to illustrate the effectiveness of the model, this study used a summative usability test case to assess the application and strength of the general fuzzy usability framework. To test the proposed fuzzy usability evaluation framework [1], a standard summative usability test was conducted to benchmark the overall usability of a specific network management software. Based on the test data, the fuzzy method was applied to incorporate both the usability scores and uncertainties involved in the multiple components of the evaluation. Then, with Monte Carlo simulation procedures, confidence intervals were used to compare the reliabilities among the fuzzy approach and two typical conventional methods combining metrics based on percentages. This case study showed that the fuzzy evaluation technique can be applied successfully for combining summative usability testing data to achieve an overall usability quality for the network software evaluated. Greater differences of confidence interval widths between the method of averaging equally percentage and weighted evaluation method, including the method of weighted percentage averages, verified the strength of the fuzzy method.

  1. Sensitivity analysis for near-surface disposal in argillaceous media using NAMMU-HYROCOIN Level 3-Test case 1

    International Nuclear Information System (INIS)

    Miller, D.R.; Paige, R.W.

    1988-07-01

    HYDROCOIN is an international project for comparing groundwater flow models and modelling strategies. Level 3 of the project concerns the application of groundwater flow models to repository performance assessment with emphasis on the treatment of sensitivity and uncertainty in models and data. Level 3, test case 1 concerns sensitivity analysis of the groundwater flow around a radioactive waste repository situated in a near surface argillaceous formation. Work on this test case has been carried out by Harwell and will be reported in full in the near future. This report presents the results obtained using the computer program NAMMU. (author)

  2. Variations in the Contouring of Organs at Risk: Test Case From a Patient With Oropharyngeal Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Nelms, Benjamin E., E-mail: alpha@canislupusllc.com [Canis Lupus LLC, Merrimac, WI (United States); Tome, Wolfgang A. [Department of Human Oncology, University of Wisconsin, Madison, WI (United States); Robinson, Greg [Radiation Oncology Resources, Goshen, IN (United States); Wheeler, James [Department of Radiation Oncology, Goshen Health System Goshen, IN (United States)

    2012-01-01

    Purpose: Anatomy contouring is critical in radiation therapy. Inaccuracy and variation in defining critical volumes will affect everything downstream: treatment planning, dose-volume histogram analysis, and contour-based visual guidance used in image-guided radiation therapy. This study quantified: (1) variation in the contouring of organs at risk (OAR) in a clinical test case and (2) corresponding effects on dosimetric metrics of highly conformal plans. Methods and Materials: A common CT data set with predefined targets from a patient with oropharyngeal cancer was provided to a population of clinics, which were asked to (1) contour OARs and (2) design an intensity-modulated radiation therapy plan. Thirty-two acceptable plans were submitted as DICOM RT data sets, each generated by a different clinical team. Using those data sets, we quantified: (1) the OAR contouring variation and (2) the impact this variation has on dosimetric metrics. New technologies were employed, including a software tool to quantify three-dimensional structure comparisons. Results: There was significant interclinician variation in OAR contouring. The degree of variation is organ-dependent. We found substantial dose differences resulting strictly from contouring variation (differences ranging from -289% to 56% for mean OAR dose; -22% to 35% for maximum dose). However, there appears to be a threshold in the OAR comparison metric beyond which the dose differences stabilize. Conclusions: The effects of interclinician variation in contouring organs-at-risk in the head and neck can be large and are organ-specific. Physicians need to be aware of the effect that variation in OAR contouring can play on the final treatment plan and not restrict their focus only to the target volumes.

  3. Integrated socio-environmental modelling: A test case in coastal Bangladesh

    Science.gov (United States)

    Lazar, Attila

    2013-04-01

    though the coastal Bangladesh test case.

  4. Broadband Fan Noise Prediction System for Turbofan Engines. Volume 3; Validation and Test Cases

    Science.gov (United States)

    Morin, Bruce L.

    2010-01-01

    Pratt & Whitney has developed a Broadband Fan Noise Prediction System (BFaNS) for turbofan engines. This system computes the noise generated by turbulence impinging on the leading edges of the fan and fan exit guide vane, and noise generated by boundary-layer turbulence passing over the fan trailing edge. BFaNS has been validated on three fan rigs that were tested during the NASA Advanced Subsonic Technology Program (AST). The predicted noise spectra agreed well with measured data. The predicted effects of fan speed, vane count, and vane sweep also agreed well with measurements. The noise prediction system consists of two computer programs: Setup_BFaNS and BFaNS. Setup_BFaNS converts user-specified geometry and flow-field information into a BFaNS input file. From this input file, BFaNS computes the inlet and aft broadband sound power spectra generated by the fan and FEGV. The output file from BFaNS contains the inlet, aft and total sound power spectra from each noise source. This report is the third volume of a three-volume set documenting the Broadband Fan Noise Prediction System: Volume 1: Setup_BFaNS User s Manual and Developer s Guide; Volume 2: BFaNS User s Manual and Developer s Guide; and Volume 3: Validation and Test Cases. The present volume begins with an overview of the Broadband Fan Noise Prediction System, followed by validation studies that were done on three fan rigs. It concludes with recommended improvements and additional studies for BFaNS.

  5. Visualizing the Bayesian 2-test case: The effect of tree diagrams on medical decision making.

    Science.gov (United States)

    Binder, Karin; Krauss, Stefan; Bruckmaier, Georg; Marienhagen, Jörg

    2018-01-01

    In medicine, diagnoses based on medical test results are probabilistic by nature. Unfortunately, cognitive illusions regarding the statistical meaning of test results are well documented among patients, medical students, and even physicians. There are two effective strategies that can foster insight into what is known as Bayesian reasoning situations: (1) translating the statistical information on the prevalence of a disease and the sensitivity and the false-alarm rate of a specific test for that disease from probabilities into natural frequencies, and (2) illustrating the statistical information with tree diagrams, for instance, or with other pictorial representation. So far, such strategies have only been empirically tested in combination for "1-test cases", where one binary hypothesis ("disease" vs. "no disease") has to be diagnosed based on one binary test result ("positive" vs. "negative"). However, in reality, often more than one medical test is conducted to derive a diagnosis. In two studies, we examined a total of 388 medical students from the University of Regensburg (Germany) with medical "2-test scenarios". Each student had to work on two problems: diagnosing breast cancer with mammography and sonography test results, and diagnosing HIV infection with the ELISA and Western Blot tests. In Study 1 (N = 190 participants), we systematically varied the presentation of statistical information ("only textual information" vs. "only tree diagram" vs. "text and tree diagram in combination"), whereas in Study 2 (N = 198 participants), we varied the kinds of tree diagrams ("complete tree" vs. "highlighted tree" vs. "pruned tree"). All versions were implemented in probability format (including probability trees) and in natural frequency format (including frequency trees). We found that natural frequency trees, especially when the question-related branches were highlighted, improved performance, but that none of the corresponding probabilistic visualizations did.

  6. IASI's sensitivity to near-surface carbon monoxide (CO): Theoretical analyses and retrievals on test cases

    Science.gov (United States)

    Bauduin, Sophie; Clarisse, Lieven; Theunissen, Michael; George, Maya; Hurtmans, Daniel; Clerbaux, Cathy; Coheur, Pierre-François

    2017-03-01

    Separating concentrations of carbon monoxide (CO) in the boundary layer from the rest of the atmosphere with nadir satellite measurements is of particular importance to differentiate emission from transport. Although thermal infrared (TIR) satellite sounders are considered to have limited sensitivity to the composition of the near-surface atmosphere, previous studies show that they can provide information on CO close to the ground in case of high thermal contrast. In this work we investigate the capability of IASI (Infrared Atmospheric Sounding Interferometer) to retrieve near-surface CO concentrations, and we quantitatively assess the influence of thermal contrast on such retrievals. We present a 3-part analysis, which relies on both theoretical forward simulations and retrievals on real data, performed for a large range of negative and positive thermal contrast situations. First, we derive theoretically the IASI detection threshold of CO enhancement in the boundary layer, and we assess its dependence on thermal contrast. Then, using the optimal estimation formalism, we quantify the role of thermal contrast on the error budget and information content of near-surface CO retrievals. We demonstrate that, contrary to what is usually accepted, large negative thermal contrast values (ground cooler than air) lead to a better decorrelation between CO concentrations in the low and the high troposphere than large positive thermal contrast (ground warmer than the air). In the last part of the paper we use Mexico City and Barrow as test cases to contrast our theoretical predictions with real retrievals, and to assess the accuracy of IASI surface CO retrievals through comparisons to ground-based in-situ measurements.

  7. Comparison of ORSAT and SCARAB Reentry Analysis Tools for a Generic Satellite Test Case

    Science.gov (United States)

    Kelley, Robert L.; Hill, Nicole M.; Rochelle, W. C.; Johnson, Nicholas L.; Lips, T.

    2010-01-01

    Reentry analysis is essential to understanding the consequences of the full life cycle of a spacecraft. Since reentry is a key factor in spacecraft development, NASA and ESA have separately developed tools to assess the survivability of objects during reentry. Criteria such as debris casualty area and impact energy are particularly important to understanding the risks posed to people on Earth. Therefore, NASA and ESA have undertaken a series of comparison studies of their respective reentry codes for verification and improvements in accuracy. The NASA Object Reentry Survival Analysis Tool (ORSAT) and the ESA Spacecraft Atmospheric Reentry and Aerothermal Breakup (SCARAB) reentry analysis tools serve as standard codes for reentry survivability assessment of satellites. These programs predict whether an object will demise during reentry and calculate the debris casualty area of objects determined to survive, establishing the reentry risk posed to the Earth's population by surviving debris. A series of test cases have been studied for comparison and the most recent uses "Testsat," a conceptual satellite composed of generic parts, defined to use numerous simple shapes and various materials for a better comparison of the predictions of these two codes. This study is an improvement on the others in this series because of increased consistency in modeling techniques and variables. The overall comparison demonstrated that the two codes arrive at similar results. Either most objects modeled resulted in close agreement between the two codes, or if the difference was significant, the variance could be explained as a case of semantics in the model definitions. This paper presents the main results of ORSAT and SCARAB for the Testsat case and discusses the sources of any discovered differences. Discussion of the results of previous comparisons is made for a summary of differences between the codes and lessons learned from this series of tests.

  8. INTRAVAL Working group 2 summary report on Phase 2 analysis of the Finnsjoen test case

    International Nuclear Information System (INIS)

    Andersson, Peter; Winberg, A.

    1994-01-01

    A comprehensive series of tracer tests on a relatively large scale have been performed by SKB at Finnsjoen, Sweden, to increase understanding of transport phenomena which govern migration of radionuclides in major fracture zones. The conducted experiments were subsequently selected as a test in the international INTRAVAL Project, in part because the tests at Finnsjoe invite to direct address of validation of geosphere models. This report summarizes the study of the Finnsjoe test case within INTRAVAL Phase 2, which has involved nine project teams from seven countries. Porous media approaches in two dimensions dominated, although some project teams utilized one-dimensional transport models, and even three-dimensional approaches on a larger scale. The dimensionality employed did not appear to be decisive for the ability to reproduce the observed field responses. It was also demonstrated that stochastic approaches can be used in a validation process. Only four out of nine project teams studied more than one process. The general conclusion drawn is that flow and transport in the studied zone is governed by advection and that hydrodynamic dispersion is needed to explain the breakthrough curves. Matrix diffusion is assumed to have small or negligible effect. The performed analysis is dominated by numerical approaches applied on scales on the order of a 1000m. Taking scale alone into account, the results of most teams are possible to compare. A variety of validation aspects have been considered. Five teams utilized a model calibrated on one test, to predict another, whereas the two teams utilizing stochastic continuum approaches addressed; 1) validity of extrapolation of a model calibrated on one transport scale to a larger scale, 2) performance assessment implications of choice of underlying distribution model for hydraulic conductivity, respectively. 37 refs

  9. Application of mycorrhizas to ornamental horticultural crops: lisianthus (Eustoma grandiflorum) as a test case

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Ornamental crops are high-cash crops, grown under greenhouse conditions in semi-arid regions in Israel where a reduction in the native population of arbuscular mycorrhizal fungi (AMF) is expected due to routine soil disinfection. The application of AMF inoculum to the soil has been shown to be effective at improving plant growth and enhancing plant resilience to abiotic and biotic stresses. One of our aims is to introduce mycorrhizal application to ornamental crops, and a test case is presented here for two cultivars of lisianthus (Eustoma grandiflorum), one of the major ornamental crops grown in Israel. Several different methods of AMF application and their effects on growth, yield and vase life were examined in lisianthus grown in two different semi-arid locations in southern Israel. AMF enhanced lisianthus growth and yield, especially when introduced to the growth medium during seeding and to the pit hole during planting. Significantly enhanced growth and yield parameters included flowering stem length (58 {+-} 0.7 and 65.1 {+-} 0.7 cm for control and AMF treated, respectively) and number of flowering stems per square meter (73 {+-} 9 and 106 {+-} 6 for control and AMF treated, respectively); positive but non-significant effects were recorded on stem weight, number of flowers per stem and vase life of cut flowers. Yield enhancement was recorded under both low and regular phosphorus conditions. Although not significant, higher resilience against two pathogenic fungi was also recorded following AMF inoculation (23 {+-} 13 and 41 {+-} 10 surviving plants for control and AMF treated, respectively). Hence, AMF is suggested to be a useful growth amendment for promotion of lisianthus commercial production, and may potentially be applied to additional ornamental crops. (Author) 23 refs.

  10. Sustained diabetes risk reduction after real life and primary health care setting implementation of the diabetes in Europe prevention using lifestyle, physical activity and nutritional intervention (DE-PLAN project

    Directory of Open Access Journals (Sweden)

    Aleksandra Gilis-Januszewska

    2017-02-01

    Full Text Available Abstract Background Real life implementation studies performed in different settings and populations proved that lifestyle interventions in prevention of type 2 diabetes can be effective. However, little is known about long term results of these translational studies. Therefore, the purpose of this study was to examine the maintenance of diabetes type 2 risk factor reduction achieved 1 year after intervention and during 3 year follow-up in primary health care setting in Poland. Methods Study participants (n = 262, middle aged, slightly obese, with increased type 2 diabetes risk ((age 55.5 (SD = 11.3, BMI 32 (SD = 4.8, Finnish Diabetes Risk Score FINDRISC 18.4 (SD = 2.9 but no diabetes at baseline, were invited for 1 individual and 10 group lifestyle counselling sessions as well as received 6 motivational phone calls and 2 letters followed by organized physical activity sessions combined with counselling to increase physical activity. Measurements were performed at baseline and then repeated 1 and 3 years after the initiation of the intervention. Results One hundred five participants completed all 3 examinations (baseline age 56.6 (SD = 10.7, BMI 31.1 (SD = 4.9, FINDRISC 18.57 (SD = 3.09. Males comprised 13% of the group, 10% of the patients presented impaired fasting glucose (IFG and 14% impaired glucose tolerance (IGT. Mean weight of participants decreased by 2.27 kg (SD = 5.25 after 1 year (p = 5% was achieved after 1 and 3 years by 27 and 19% of the participants, respectively. Repeated measures analysis revealed significant changes observed from baseline to year 1 and year 3 in: weight (p = 0.048, BMI (p = 0.001, total cholesterol (p = 0.013, TG (p = 0.061, fasting glucose level (p = 0.037 and FINDRISC (p = 0.001 parameters. The conversion rate to diabetes was 2% after 1 year and 7% after 3 years. Conclusions Type 2 diabetes prevention in real life primary health care setting through lifestyle intervention delivered by trained nurses leads

  11. Effectiveness of Cetuximab as First-Line Therapy for Patients With Wild-Type KRAS and Unresectable Metastatic Colorectal Cancer in Real-Life Practice: Results of the EREBUS Cohort.

    Science.gov (United States)

    Rouyer, Magali; François, Eric; Cunha, Antonio Sa; Monnereau, Alain; Noize, Pernelle; Robinson, Philip; Droz-Perroteau, Cécile; Le Monies de Sagazan, Alise; Jové, Jérémy; Lassalle, Régis; Moore, Nicholas; Fourrier-Réglat, Annie; Smith, Denis

    2018-01-31

    Few real-life data are available on cetuximab benefit. The EREBUS cohort was performed to assess metastases resection rate, use, safety, and survival outcomes in wild-type KRAS (Kirsten rat sarcoma viral oncogene) patients with initially unresectable metastatic colorectal cancer (mCRC) treated by cetuximab in real practice. The study cohort comprised patients initiating cetuximab between January 2009 and December 2010 in 65 French centers, with initially unresectable mCRC and wild-type KRAS. Kaplan-Meier analysis estimated 24-month probability of metastases resection and progression-free survival, and 36-month overall survival (OS). Cox proportional hazards models investigated factors associated with survival outcomes. Among the 389 patients included, median age was 64 years, 67.4% were male, 77.9% had Eastern Cooperative Oncology Group performance status ≤ 1, and hepatic metastases were most frequent at baseline (n = 146 exclusively, n = 149 not exclusively, n = 94 nonliver only). Median duration of cetuximab use was 4.8 months. Metastases resection was performed in 106 patients (27.2%) (n = 60 liver exclusively, n = 33 not exclusively, n = 13 nonliver only). The 24-month probability (95% confidence interval) of metastases resection occurrence was 33.6% (28.5-39.3). Median progression-free survival was 9.2 (8.5-9.8) months for the total cohort and 13.0 (11.6-15.1) for those resected; median OS was 23.0 (20.6-26.3) months for the total cohort and was not reached after 36 months for those who were resected. The strongest factor associated with higher OS was metastases resection with complete remission (hazard ratio, 0.41; 95% confidence interval, 0.19-0.88). This cohort study highlights in French real-life practice the benefit of cetuximab in first-line mCRC therapy, notably in case of metastases resection with complete remission. Copyright © 2018 Elsevier Inc. All rights reserved.

  12. Sustained diabetes risk reduction after real life and primary health care setting implementation of the diabetes in Europe prevention using lifestyle, physical activity and nutritional intervention (DE-PLAN) project.

    Science.gov (United States)

    Gilis-Januszewska, Aleksandra; Lindström, Jaana; Tuomilehto, Jaakko; Piwońska-Solska, Beata; Topór-Mądry, Roman; Szybiński, Zbigniew; Peltonen, Markku; Schwarz, Peter E H; Windak, Adam; Hubalewska-Dydejczyk, Alicja

    2017-02-15

    Real life implementation studies performed in different settings and populations proved that lifestyle interventions in prevention of type 2 diabetes can be effective. However, little is known about long term results of these translational studies. Therefore, the purpose of this study was to examine the maintenance of diabetes type 2 risk factor reduction achieved 1 year after intervention and during 3 year follow-up in primary health care setting in Poland. Study participants (n = 262), middle aged, slightly obese, with increased type 2 diabetes risk ((age 55.5 (SD = 11.3), BMI 32 (SD = 4.8), Finnish Diabetes Risk Score FINDRISC 18.4 (SD = 2.9)) but no diabetes at baseline, were invited for 1 individual and 10 group lifestyle counselling sessions as well as received 6 motivational phone calls and 2 letters followed by organized physical activity sessions combined with counselling to increase physical activity. Measurements were performed at baseline and then repeated 1 and 3 years after the initiation of the intervention. One hundred five participants completed all 3 examinations (baseline age 56.6 (SD = 10.7)), BMI 31.1 (SD = 4.9)), FINDRISC 18.57 (SD = 3.09)). Males comprised 13% of the group, 10% of the patients presented impaired fasting glucose (IFG) and 14% impaired glucose tolerance (IGT). Mean weight of participants decreased by 2.27 kg (SD = 5.25) after 1 year (p = Diabetes risk (FINDRISC) declined after one year by 2.8 (SD = 3.6) (p = 0.001) and the decrease by 2.26 (SD = 4.27) was maintained after 3 years (p = 0.001). Body mass reduction by >5% was achieved after 1 and 3 years by 27 and 19% of the participants, respectively. Repeated measures analysis revealed significant changes observed from baseline to year 1 and year 3 in: weight (p = 0.048), BMI (p = 0.001), total cholesterol (p = 0.013), TG (p = 0.061), fasting glucose level (p = 0.037) and FINDRISC (p = 0.001) parameters. The conversion rate to diabetes was 2% after 1 year and 7% after 3 years

  13. Real-Life and RCT Participants

    DEFF Research Database (Denmark)

    Reyes, Carlen; Pottegård, Anton; Schwarz, Peter

    2016-01-01

    We aimed to characterize incident users of alendronate from Denmark and Spain, and investigate their eligibility for participation in the pivotal Fracture Intervention Trial (FIT). This is an international cross-sectional study, where the data were obtained from the SIDIAP database (Sistema d...... of alendronate who were not eligible to participate in FIT. 14,316 and 21,221 subjects initiated alendronate in 2006-2007 (SIDIAP) and 2005-2006 (DHR), respectively. SIDIAP and DHR alendronate user cohorts had 2347 (16.4 %) and 5275 (24.9 %) subjects aged >80 years old, reported 9 (0.1 %) and 91 (0.......4 %) diagnoses of myocardial infarction, 423 (3 %) and 368 (1.7 %) of erosive gastro-intestinal disease, 200 (1.4 %) and 1109 (5.2 %) of dyspepsia, and 349 (2.4 %) and 149 (0.7 %) of metabolic bone disease, all of which were exclusion criteria in FIT. Men [3818 (26.7 %) in SIDIAP and 3885 (18.3 %) in DHR...

  14. Acute gastroenteritis: from guidelines to real life

    Directory of Open Access Journals (Sweden)

    Chung M Chow

    2010-07-01

    Full Text Available Chung M Chow1, Alexander KC Leung2, Kam L Hon11Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, PR China; 2Department of Pediatrics, The University of Calgary, Calgary, Alberta, CanadaAbstract: Acute gastroenteritis is a very common disease. It causes significant mortality in developing countries and significant economic burden to developed countries. Viruses are ­responsible for approximately 70% of episodes of acute gastroenteritis in children and rotavirus is one of the best studied of these viruses. Oral rehydration therapy is as effective as i­ntravenous therapy in treating mild to moderate dehydration in acute gastroenteritis and is strongly r­ecommended as the first line therapy. However, the oral rehydration solution is described as an underused simple solution. Vomiting is one of the main reasons to explain the underuse of oral rehydration therapy. Antiemetics are not routinely recommended in treating acute gastroenteritis, though they are still commonly prescribed. Ondansetron is one of the best studied antiemetics and its role in enhancing the compliance of oral rehydration therapy and decreasing the rate of hospitalization has been proved recently. The guidelines regarding the recommendation on antiemetics have been changed according to the evidence of these recent studies.Keywords: gastroenteritis, vomiting, antiemetic, ondansetron, rotavirus, oral rehydration therapy, intravenous therapy, guideline

  15. When Cognitive Sciences Meet Real Life

    DEFF Research Database (Denmark)

    Smith, Viktor; Selsøe Sørensen, Henrik; Nissilä, Niina

    2012-01-01

    Consumers in general pay little attention to food labels. The study of expert-to-layperson communication related to food labels integrates many aspects of what cognitive sciences are about: Knowledge modelling and knowledge transfer, termhood and precision as well as fuzziness, interaction between...

  16. Real life working shift assignment problem

    Science.gov (United States)

    Sze, San-Nah; Kwek, Yeek-Ling; Tiong, Wei-King; Chiew, Kang-Leng

    2017-07-01

    This study concerns about the working shift assignment in an outlet of Supermarket X in Eastern Mall, Kuching. The working shift assignment needs to be solved at least once in every month. Current approval process of working shifts is too troublesome and time-consuming. Furthermore, the management staff cannot have an overview of manpower and working shift schedule. Thus, the aim of this study is to develop working shift assignment simulation and propose a working shift assignment solution. The main objective for this study is to fulfill manpower demand at minimum operation cost. Besides, the day off and meal break policy should be fulfilled accordingly. Demand based heuristic is proposed to assign working shift and the quality of the solution is evaluated by using the real data.

  17. Real Life Experiences with Experience Design

    DEFF Research Database (Denmark)

    Dalsgård, Peter; Halskov, Kim

    2006-01-01

    technologies for knowledge dissemination and marketing, in cooperation with public institutions and businesses. We argue that collaborative formulation of core design intentions and values is a valuable instrument in guiding experience design processes, and present three cases from this project, two of which...... resulted in interactive installations. The case installations range from walk-up-and-use consoles, to immersive, responsive, environments based on bodily interaction. We compare the installations, and discuss the interrelations between the resulting interfaces and the intentions for creating...

  18. Real Life Experiences with Experience Design

    DEFF Research Database (Denmark)

    Dalsgård, Peter; Halskov, Kim

    2006-01-01

    resulted in interactive installations. The case installations range from walk-up-and-use consoles, to immersive, responsive, environments based on bodily interaction. We compare the installations, and discuss the interrelations between the resulting interfaces and the intentions for creating...

  19. Gravitational Potential: Real-life Results

    Science.gov (United States)

    2016-01-01

    left wall and smallest at the right wall. His reasoning is that the surface of the water must be an equipotential , so that gh must be constant on...distant vertical tube. The equipotentials are concentric spheres centered on the point mass. In like fashion, the water surface in Baird’s room...water would ‘seek its own level’. The surface is merely an equipotential surface . If we scoop water out of a pool, the sur- rounding water will rush

  20. Chemotherapy Treatment of Elderly Patients (≥70 Years) with Non-Small Cell Lung Cancer: A Seven-Year Retrospective Study of Real-Life Clinical Practice at Karolinska University Hospital, Sweden.

    Science.gov (United States)

    Koyi, Hirsh; Hillerdal, Gunnar; Andersson, Olov; Kölbeck, Karl-Gustav; Liv, Per; Brandén, Eva

    2015-01-01

    An increasing proportion of cancer patients are aged >65 years and many are aged >70 years. Treatment of the elderly with lung cancer has, therefore, become an important issue; so we performed a retrospective study of our patients to demonstrate how elderly patients with NSCLC are treated in real-life, clinical practice. All patients aged ≥70 years with NSCLC at our department were reviewed retrospectively. In total, 1059 patients (50.8% of all NSCLC patients). Of these patients, 243 (22.9%) received chemotherapy, 164 (70.4%) of whom were treated with a platinum doublet using carboplatin. Second- and third-line chemotherapy were given to 31.4% and 13.9% of patients, respectively. Median overall survival was 289 and 320 days for male and female patients, respectively. Patients with performance status (PS) 0 experienced significantly better survival than patients with PS1 or PS 2: 410, 314, and 204 days, respectively. Age was of less importance, with patients aged 70-79 years versus those aged ≥80 years. Treatment of elderly NSCLC patients with chemotherapy is feasible if they have a good PS and appears to prolong survival. In this study, we found no significant differences in survival either between age groups or genders.

  1. The effect of icotinib combined with chemotherapy in untreated non-small-cell lung cancer that harbored EGFR-sensitive mutations in a real-life setting: a retrospective analysis.

    Science.gov (United States)

    Wang, Lulu; Li, Yan; Li, Luchun; Wu, Zhijuan; Yang, Dan; Ma, Huiwen; Wang, Donglin

    2018-01-01

    This study was conducted to compare the efficacy of a combination of icotinib and chemotherapy with icotinib or chemotherapy alone in untreated non-small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR)-sensitive mutations and to analyze the curative effect of different treatments on different genetic mutations (EGFR 19 exon deletion and L858R mutation) in a real-life setting. One hundred ninety-one patients were studied in this retrospective analysis from January 2013 to December 2015. The baseline characteristics, curative effects and adverse events of patients were analyzed. The primary endpoint was progression free survival (PFS). Longer PFS and overall survival (OS), and better objective response rate (ORR) were observed in the combination group compared to icotinib or chemotherapy along. For patients with an EGFR 19 exon deletion, the PFS, OS, and ORR in the combination group were superior to those in the icotinib or chemotherapy group. For the patients with the EGFR L858R mutation, better PFS and ORR were observed in the combination group, but OS was not obviously prolonged. Grade 3 or 4 adverse events were most commonly reported with combination therapy or chemotherapy alone. No possible drug-related interstitial lung disease or of drug related deaths occurred. The combination of icotinib and chemotherapy in patients with untreated NSCLC harboring sensitive EGFR mutations resulted in improved PFS and OS, especially in those who harbored the EGFR exon 19 deletion.

  2. The Test Case of HD 26965: Difficulties Disentangling Weak Doppler Signals from Stellar Activity

    Science.gov (United States)

    Díaz, Matías R.; Jenkins, James S.; Tuomi, Mikko; Butler, R. Paul; Soto, Maritza G.; Teske, Johanna K.; Feng, Fabo; Shectman, Stephen A.; Arriagada, Pamela; Crane, Jeffrey D.; Thompson, Ian B.; Vogt, Steven S.

    2018-03-01

    We report the discovery of a radial velocity signal that can be interpreted as a planetary-mass candidate orbiting the K dwarf HD 26965, with an orbital period of 42.364 ± 0.015 days, or alternatively, as the presence of residual, uncorrected rotational activity in the data. Observations include data from HIRES, PFS, CHIRON, and HARPS, where 1111 measurements were made over 16 years. Our best solution for HD 26965 b is consistent with a super-Earth that has a minimum mass of 6.92 ± 0.79 {M}\\oplus orbiting at a distance of 0.215 ± 0.008 au from its host star. We have analyzed the correlation between spectral activity indicators and the radial velocities from each instrument, showing moderate correlations that we include in our model. From this analysis, we recover a ∼38-day signal, which matches some literature values of the stellar rotation period. However, from independent Mt. Wilson HK data for this star, we find evidence for a significant 42-day signal after subtraction of longer period magnetic cycles, casting doubt on the planetary hypothesis for this period. Although our statistical model strongly suggests that the 42-day signal is Doppler in origin, we conclude that the residual effects of stellar rotation are difficult to fully model and remove from this data set, highlighting the difficulties to disentangle small planetary signals and photospheric noise, particularly when the orbital periods are close to the rotation period of the star. This study serves as an excellent test case for future works that aim to detect small planets orbiting “Sun-like” stars using radial velocity measurements. Some of the data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation.

  3. Strategy for a Rock Mechanics Site Descriptive Model. A test case based on data from the Aespoe HRL

    International Nuclear Information System (INIS)

    Hudson, John A

    2002-06-01

    In anticipation of the SKB Site Investigations for radioactive waste disposal, an approach has been developed for the Rock Mechanics Site Descriptive Model. This approach was tested by predicting the rock mechanics properties of a 600 m x 180 m x 120 m rock volume at the Aespoe Hard Rock Laboratory (HRL) using limited borehole data of the type typically obtained during a site investigation. These predicted properties were then compared with 'best estimate' properties obtained from a study of the test rock volume using additional information, mainly tunnel data. The exercise was known as the Test Case, and is the subject of this Report. Three modelling techniques were used to predict the rock properties: the 'empirical approach' - the rock properties were estimated using rock mass classification schemes and empirical correlation formulae; the 'theoretical approach' - the rock properties were estimated using numerical modelling techniques; and the 'stress approach' - the rock stress state was estimated using primary data and numerical modelling. These approaches are described separately and respectively. Following an explanation of the context for the Test Case within the strategy for developing the Rock Mechanics Site Descriptive Model, conditions at the Aespoe HRL are described in Chapter 2. The Test Case organization and the suite of nine Protocols used to ensure that the work was appropriately guided and co-ordinated are described in Chapter 3. The methods for predicting the rock properties and the rock stress, and comparisons with the 'best estimate' properties of the actual conditions, are presented in Chapters 4 and 5. Finally, the conclusions from this Test Case exercise are given in Chapter 6. General recommendations for the management of this type of Test Case are also included

  4. Strategy for a Rock Mechanics Site Descriptive Model. A test case based on data from the Aespoe HRL

    Energy Technology Data Exchange (ETDEWEB)

    Hudson, John A (ed.) [Rock Engineering Consultants, Welwyn Garden City (United Kingdom)

    2002-06-01

    In anticipation of the SKB Site Investigations for radioactive waste disposal, an approach has been developed for the Rock Mechanics Site Descriptive Model. This approach was tested by predicting the rock mechanics properties of a 600 m x 180 m x 120 m rock volume at the Aespoe Hard Rock Laboratory (HRL) using limited borehole data of the type typically obtained during a site investigation. These predicted properties were then compared with 'best estimate' properties obtained from a study of the test rock volume using additional information, mainly tunnel data. The exercise was known as the Test Case, and is the subject of this Report. Three modelling techniques were used to predict the rock properties: the 'empirical approach' - the rock properties were estimated using rock mass classification schemes and empirical correlation formulae; the 'theoretical approach' - the rock properties were estimated using numerical modelling techniques; and the 'stress approach' - the rock stress state was estimated using primary data and numerical modelling. These approaches are described separately and respectively. Following an explanation of the context for the Test Case within the strategy for developing the Rock Mechanics Site Descriptive Model, conditions at the Aespoe HRL are described in Chapter 2. The Test Case organization and the suite of nine Protocols used to ensure that the work was appropriately guided and co-ordinated are described in Chapter 3. The methods for predicting the rock properties and the rock stress, and comparisons with the 'best estimate' properties of the actual conditions, are presented in Chapters 4 and 5. Finally, the conclusions from this Test Case exercise are given in Chapter 6. General recommendations for the management of this type of Test Case are also included.

  5. The Arctic as a test case for an assessment of climate impacts on national security.

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, Mark A.; Zak, Bernard Daniel; Backus, George A.; Ivey, Mark D.; Boslough, Mark Bruce Elrick

    2008-11-01

    The Arctic region is rapidly changing in a way that will affect the rest of the world. Parts of Alaska, western Canada, and Siberia are currently warming at twice the global rate. This warming trend is accelerating permafrost deterioration, coastal erosion, snow and ice loss, and other changes that are a direct consequence of climate change. Climatologists have long understood that changes in the Arctic would be faster and more intense than elsewhere on the planet, but the degree and speed of the changes were underestimated compared to recent observations. Policy makers have not yet had time to examine the latest evidence or appreciate the nature of the consequences. Thus, the abruptness and severity of an unfolding Arctic climate crisis has not been incorporated into long-range planning. The purpose of this report is to briefly review the physical basis for global climate change and Arctic amplification, summarize the ongoing observations, discuss the potential consequences, explain the need for an objective risk assessment, develop scenarios for future change, review existing modeling capabilities and the need for better regional models, and finally to make recommendations for Sandia's future role in preparing our leaders to deal with impacts of Arctic climate change on national security. Accurate and credible regional-scale climate models are still several years in the future, and those models are essential for estimating climate impacts around the globe. This study demonstrates how a scenario-based method may be used to give insights into climate impacts on a regional scale and possible mitigation. Because of our experience in the Arctic and widespread recognition of the Arctic's importance in the Earth climate system we chose the Arctic as a test case for an assessment of climate impacts on national security. Sandia can make a swift and significant contribution by applying modeling and simulation tools with internal collaborations as well as with

  6. Treatment of MRSA pneumonia: Clinical and economic comparison of linezolid vs. vancomycin – a retrospective analysis of medical charts and re-imbursement data of real-life patient populations

    Directory of Open Access Journals (Sweden)

    Wilke, Michael H.

    2017-01-01

    Full Text Available Objectives: To supplement the data collected in randomized clinical trials, the present study in patients with methicillin resistant (MRSA pneumonia was conducted to explore the clinical effectiveness of linezolid and vancomycin in a routine clinical setting. Further, the overall costs of the patients' stay in the intensive care unit (ICU were compared.Methods: This was a retrospective analysis of medical and reimbursement data of adult patients who were treated for MRSA pneumonia with linezolid or vancomycin. Since the subjects were not randomly assigned to treatments, propensity score adjustment was applied to reduce a potential selection bias.Results: In total, 226 patients were included; 95 received linezolid and 131 received vancomycin as initial therapy for MRSA pneumonia. Switches to another antibiotic were observed in 4 patients (4.2% receiving linezolid and in 23 patients (17.6% receiving vancomycin (logistic regression analysis; odds ratio linezolid/vancomycin: 0.183; 95% confidence interval [CI]: 0.052–0.647; p<0.01. All-cause in-hospital mortality was also lower in patients receiving linezolid (22 patients [23.2%] vs. 54 patients [41.2%] (logistic regression analysis; odds ratio linezolid/vancomycin: 0.351; 95% CI: 0.184–0.671; p<0.01. The analysis of the total costs of stay in ICU did not reveal any major differences between the two treatment groups (cost ratio linezolid/vancomycin: 1.29; 95% CI: 0.84–1.98; p=0.24.Conclusions: These findings confirm in a routine clinical setting that linezolid is a valuable therapeutic alternative to vancomycin for the treatment of MRSA pneumonia. However, prospective studies in real-life patient populations are warranted.

  7. The effect of icotinib combined with chemotherapy in untreated non-small-cell lung cancer that harbored EGFR-sensitive mutations in a real-life setting: a retrospective analysis

    Directory of Open Access Journals (Sweden)

    Wang LL

    2018-04-01

    Full Text Available Lulu Wang, Yan Li, Luchun Li, Zhijuan Wu, Dan Yang, Huiwen Ma, Donglin Wang Oncology Department, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Shapingba District, Chongqing, China Purpose: This study was conducted to compare the efficacy of a combination of icotinib and chemotherapy with icotinib or chemotherapy alone in untreated non-small cell lung cancer (NSCLC patients harboring epidermal growth factor receptor (EGFR-sensitive mutations and to analyze the curative effect of different treatments on different genetic mutations (EGFR 19 exon deletion and L858R mutation in a real-life setting. Patients and methods: One hundred ninety-one patients were studied in this retrospective analysis from January 2013 to December 2015. The baseline characteristics, curative effects and adverse events of patients were analyzed. The primary endpoint was progression free survival (PFS. Results: Longer PFS and overall survival (OS, and better objective response rate (ORR were observed in the combination group compared to icotinib or chemotherapy along. For patients with an EGFR 19 exon deletion, the PFS, OS, and ORR in the combination group were superior to those in the icotinib or chemotherapy group. For the patients with the EGFR L858R mutation, better PFS and ORR were observed in the combination group, but OS was not obviously prolonged. Grade 3 or 4 adverse events were most commonly reported with combination therapy or chemotherapy alone. No possible drug-related interstitial lung disease or of drug related deaths occurred. Conclusion: The combination of icotinib and chemotherapy in patients with untreated NSCLC harboring sensitive EGFR mutations resulted in improved PFS and OS,especially in those who harbored the EGFR exon 19 deletion. Keywords: non-small-cell lung cancer, EGFR-TKI, icotinib, chemotherapy, first-line treatment

  8. Colorimetric anion sensors based on positional effect of nitro group for recognition of biologically relevant anions in organic and aqueous medium, insight real-life application and DFT studies

    Science.gov (United States)

    Singh, Archana; Sahoo, Suban K.; Trivedi, Darshak R.

    2018-01-01

    A new six colorimetric receptors A1-A6 were designed and synthesized, characterized by typical common spectroscopic techniques like FT-IR, UV-Visible, 1H NMR, 13C NMR and ESI-MS. The receptor A1 and A2 exhibit a significant naked-eye response towards F- and AcO- ions in DMSO. Due to presences of the NO2 group at para and ortho position with extended π-conjugation of naphthyl group carrying sbnd OH as a binding site. Compared to receptor A2, A1 is extremely capable of detecting F- and AcO- ions present in the form of sodium salts in an aqueous medium. This is owed to the occurrence of sbnd NO2 group at para position induced in increasing the acidity of sbnd OH proton. Consequently, it easily gets deprotonated in aqueous media. The detection limit of receptor A1 was turned out to be 0.40 and 0.35 ppm for F- and AcO- ions which is beneath WHO permission level (1.0 ppm). Receptor A1 shows a solitary property of solvatochromism in different aprotic solvents in presence of AcO- ion. Receptor A1 depicts high selectivity towards AcO- ion in DMSO: HEPES buffer (9:1, v/v). Receptor A1 proved itself for real life application by detecting anion in solution and solid state. The binding mechanism of receptor A1 with AcO- and F- ions was monitored from 1HNMR titration and DFT study.

  9. Electrothermal vaporisation ICP-mass spectrometry (ETV-ICP-MS) for the determination and speciation of trace elements in solid samples - A review of real-life applications from the author's lab

    Energy Technology Data Exchange (ETDEWEB)

    Vanhaecke, Frank; Resano, Martin; Moens, Luc [Laboratory of Analytical Chemistry, Ghent University, Institute for Nuclear Sciences, Proeftuinstraat 86, 9000 Ghent (Belgium)

    2002-09-01

    The use of electrothermal vaporisation (ETV) from a graphite furnace as a means of sample introduction in inductively coupled plasma mass spectrometry (ICP-MS) permits the direct analysis of solid samples. A multi-step furnace temperature programme is used to separate the vaporisation of the target element(s) and of the matrix components from one another. Sometimes, a chemical modifier is used to enable a higher thermal pre-treatment temperature, by avoiding premature analyte losses (stabilisation) or promoting the selective volatilisation of matrix components. In almost all instances, accurate results can be obtained via external calibration or single standard addition using an aqueous standard solution. Absolute limits of detection are typically 1 pg, which corresponds to 1 ng/g for a typical sample mass of 1 mg. Real-life applications carried out in the author's lab are used to illustrate the utility of this approach. These applications aim at trace element determination in industrial and environmental materials. The industrial materials analysed include different types of plastics - Carilon, polyethylene, poly(ethyleneterephtalate) and polyamide - and photo- and thermographic materials. As samples from environmental origin, plant material, animal tissue and sediments were investigated. Some applications aimed at a multi-element determination, while in other, the content of a single, but often challenging, element (e.g., Si or S) had to be measured. ETV-ICP-MS was also used in elemental speciation studies. Separation of Se-containing proteins was accomplished using polyacrylamide gel electrophoresis (PAGE). Subsequent quantification of the Se content in the protein spots was carried out using ETV-ICP-MS. As the volatilisation of methylmercury and inorganic mercury could be separated from one another with respect to time, no chromatographic or electrophoretic separation procedure was required, but ETV-ICP-MS as such sufficed for Hg speciation in fish tissue

  10. Frequency and predictors of confirmed hypoglycaemia in type 1 and insulin-treated type 2 diabetes mellitus patients in a real-life setting: results from the DIALOG study.

    Science.gov (United States)

    Cariou, B; Fontaine, P; Eschwege, E; Lièvre, M; Gouet, D; Huet, D; Madani, S; Lavigne, S; Charbonnel, B

    2015-04-01

    DIALOG assessed the prevalence and predictors of hypoglycaemia in patients with type 1 (T1DM) or insulin-treated type 2 diabetes mellitus (T2DM) in a real-life setting. In this observational study, insulin-treated patients (n=3048) completed prospective daily questionnaires reporting the frequency and consequences of severe/confirmed non-severe hypoglycaemia over 30 days. Patients (n=3743) also retrospectively reported severe hypoglycaemia over the preceding year. In this prospective survey, 85.3% and 43.6% of patients with T1DM and T2DM, respectively, reported experiencing at least one confirmed hypoglycaemic event over 30 days, while 13.4% and 6.4%, respectively, reported at least one severe event. Hypoglycaemia frequency increased with longer duration of diabetes and insulin therapy. Strongly predictive factors for hypoglycaemia were previous hypoglycaemia, >2 injections/day, BMIinsulin therapy>10 years. HbA1c level was not predictive of hypoglycaemia in either T1DM or T2DM. The confirmed hypoglycaemia rate was increased in the lowest compared with the highest tertile of HbA1c in T1DM, but not T2DM. At the time of enrolment, physicians reported severe hypoglycaemia in 23.6% and 11.9% of T1DM and T2DM patients, respectively, during the preceding year; the retrospective survey yielded frequencies of 31.5% and 21.7%, respectively. Also, severe hypoglycaemia led to medical complications in 10.7% and 7.8% of events in T1DM and T2DM patients, respectively, over 30 days. Using a unique combined prospective and retrospective approach, the DIALOG study found a relatively high frequency of hypoglycaemia among insulin-treated patients. These findings emphasize the importance of a patient-centred approach for managing diabetes in which hypoglycaemia risk evaluation is critical. ClinicalTrials.gov: NCT01628341. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  11. Real-life prevalence of resistance-associated variants against non-structural protein 5A inhibitors and efficiency of Daclatasvir + Asunaprevir therapy in Korean patients with genotype 1b hepatitis C.

    Science.gov (United States)

    Yu, Jung Hwan; Lee, Jung Il; Lee, Kwan Sik; Kim, Ja Kyung

    2017-08-24

    Direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) treatment are tolerable and highly effective in a shorter period of time than before. However, resistance-associated variants (RAVs) can affect the efficacy of DAAs. The aim of this study was to investigate the real-life prevalence of RAVs against non-structural protein 5A (NS5A) inhibitors in Korean patients with genotype 1b chronic hepatitis C. All consecutive patients with CHC genotype 1b who underwent a RAV test at a single referral hospital were enrolled. A total of 142 patients (male 53, female 89) were tested for RAVs. The average age of the patients was 58 years. Liver cirrhosis was found in 34.5% (49/142) of patients, and 19.0% (29/142) of patients had previously undergone interferon-based treatment. Twenty-nine patients (20.4%) had RAVs (Y93 or L31). Y93H, L31, or Y93H with L31 were detected in 22 (15.5%), 8 (5.6%), and 1 (0.7%) patients, respectively. The presence of RAV was not affected by previous interferon-based treatment or by the existence of liver cirrhosis. Among 113 patients without baseline NS5A RAVs, 72 patients started daclatasvir (DCV) + asunaprevir (ASV) treatment and 95% (68/72) patients achieved virologic response at week 4. Virologic response at end of treatment and sustained virologic response at 12 weeks after treatment were achieved by 94% (68/72) and 94% (68/72), respectively. In Korean patients with genotype 1b CHC, 20.4% (29 of 142) of patients showed RAVs against NS5A inhibitors. Patient without RAVs who received treatment with DCV + ASV showed high virologic response rates in Korea.

  12. Quality of life improvement after a three-year course of sublingual immunotherapy in patients with house dust mite and grass pollen induced allergic rhinitis: results from real-life.

    Science.gov (United States)

    Novakova, Silviya Mihaylova; Staevska, Maria Toncheva; Novakova, Plamena Ivanova; Yoncheva, Manuela Dimitrova; Bratoycheva, Maria Stoykova; Musurlieva, Nina Mihaylova; Tzekov, Valeri Dimitrov; Nicolov, Dimitar Georgiev

    2017-09-29

    Along with its high prevalence, the burden of allergic rhinitis rests upon the serious impact on quality of life of patients. Allergic rhinitis is associated with impairments in daily activities, work and school performance, and practical problems. Patients suffer from sleep disorders and emotional problems. Тhe advantages of sublingual immunotherapy on quality of life have only recently begun to emerge. The objective of this prospective real-life study was to evaluate the effect of a three-year course of sublingual immunotherapy with house dust mite (HDM) and grass pollen extracts on quality of life in adults with allergic rhinitis. A total number of 191 adult patients [105 (54,979%) men; mean age 27.3 years (SD-6.14)] with moderate to severe allergic rhinitis and clinically relevant sensitization to house dust mites or grass pollen were prospectively evaluated in the course of management of their disease. Health-related quality of life was assessed by Rhinoconjunctivitis Quality of Life Questionnaire at baseline and after three-year course of sublingual immunotherapy. The mean overall Qol score assessed at baseline and at the end of the third year of treatment decreased significantly in patients treated with HDM extract (from 2.95 to 0.76) as well as with Grass pollen extract (from 2.83 to 1.22) (р life provided evidence that a three-year course of SLIT with HDM extract as well as with grass pollen extract significantly increased QoL in patients with allergic rhinitis.

  13. Eukaryotic Cell Cycle as a Test Case for Modeling Cellular Regulation in a Collaborative Problem-Solving Environment

    Science.gov (United States)

    2007-03-01

    computer models of cell cycle regulation in a variety of organisms, including yeast cells, amphibian embryos, bacterial cells and human cells. These...and meiosis ), but they do not nullify the central role played by irreversible, alternating START and FINISH transitions in the cell cycle. 32...AFRL-IF-RS-TR-2007-69 Final Technical Report March 2007 EUKARYOTIC CELL CYCLE AS A TEST CASE FOR MODELING CELLULAR REGULATION IN A

  14. A practical model-based statistical approach for generating functional test cases: application in the automotive industry

    OpenAIRE

    Awédikian , Roy; Yannou , Bernard

    2012-01-01

    International audience; With the growing complexity of industrial software applications, industrials are looking for efficient and practical methods to validate the software. This paper develops a model-based statistical testing approach that automatically generates online and offline test cases for embedded software. It discusses an integrated framework that combines solutions for three major software testing research questions: (i) how to select test inputs; (ii) how to predict the expected...

  15. Reactor protection system software test-case selection based on input-profile considering concurrent events and uncertainties

    International Nuclear Information System (INIS)

    Khalaquzzaman, M.; Lee, Seung Jun; Cho, Jaehyun; Jung, Wondea

    2016-01-01

    Recently, the input-profile-based testing for safety critical software has been proposed for determining the number of test cases and quantifying the failure probability of the software. Input-profile of a reactor protection system (RPS) software is the input which causes activation of the system for emergency shutdown of a reactor. This paper presents a method to determine the input-profile of a RPS software which considers concurrent events/transients. A deviation of a process parameter value begins through an event and increases owing to the concurrent multi-events depending on the correlation of process parameters and severity of incidents. A case of reactor trip caused by feedwater loss and main steam line break is simulated and analyzed to determine the RPS software input-profile and estimate the number of test cases. The different sizes of the main steam line breaks (e.g., small, medium, large break) with total loss of feedwater supply are considered in constructing the input-profile. The uncertainties of the simulation related to the input-profile-based software testing are also included. Our study is expected to provide an option to determine test cases and quantification of RPS software failure probability. (author)

  16. A comparison of breath- and blood-alcohol test results from real-life policing situations: a one-year study of data from the Central Hessian police district in Germany.

    Science.gov (United States)

    Roiu, Immanuel; Birngruber, Christoph G; Spencer, Victoria C; Wollersen, Heike; Dettmeyer, Reinhard; Verhoff, Marcel A

    2013-10-10

    So far, studies investigating the comparability of breath alcohol concentration (BrAC) with blood alcohol concentration (BAC) have focused on the accuracy of BrAC testing instruments. The presented study, conducted with cases from the district of the Middle Hessian Police Headquarters, is to the best of our knowledge the first to compare both methods under real-life conditions in normal policing situations. For a 1-year period, alcohol-impaired drunk-driving suspects, who were by criminal procedure required to give a blood sample, were offered a voluntary, additional BrAC test with a "Dräger Alcotest 7110 Evidential". The BrAC test was to be administered as soon as possible after the suspect had been apprehended, without, however, delaying the collection of the blood sample. Ninety-two cases could be included in our study. In 30 cases, a blood sample was not taken; in 11 cases, a BrAC test could not be performed. In the remaining 51 cases, we found the following pairings of BrAC and BAC results: BrAC≥0.55 mg/l and BAC≥1.1‰ (n=39); 0.25 mg/l≤BrACmean value for the conversion factor, Q, was 2.12‰l/mg. In accord with numerous other studies, our study results would suggest a value of 2.1‰ l/mg to German legislature as a new statutory value for Q. In borderline cases, of which there were already 7 in our study with 51 cases, suspects could benefit both from a BrAC test or a BAC test, with the benefit lastly depending more on early testing time than on the test method used. Our results support the call for the earliest possible measurement of alcohol concentration values after a drunk driving offense was committed. In some situations, this can probably only be accomplished with BrAC testing. A supplementary blood sample and BAC testing could compensate for the known weaknesses of BrAC testing. Thus, the complementary use of both methods might be a viable option. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  17. The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness: A real-life study on top-level road cyclists during stage competition.

    Science.gov (United States)

    Gervasi, Marco; Sisti, Davide; Benelli, Piero; Fernández-Peña, Eneko; Calcabrini, Cinzia; Rocchi, Marco B L; Lanata, Luigi; Bagnasco, Michela; Tonti, Andrea; Vilberto, Stocchi; Sestili, Piero

    2017-07-01

    In professional road cyclists, the majority of overuse injuries affect the lower limbs and are mostly represented by contractures or muscle shortening, characterized by an increase of tone and stiffness and a variation of elasticity. Treatment and prevention of these specific conditions may include physical, supplementary, and pharmacologic support. The aim of this real-life study was to determine: first, the alterations of tone, stiffness, elasticity, and soreness of rectus femoris (RF) and biceps femoris (BF) in top class cyclists engaged in 3 multistage races, and second, whether any variable in the management of the athletes may affect the prevention and/or reduction of such alterations.Twenty-three professional cyclists competing in 3 international, cycling stage races were assessed. Athletes could receive, upon the approval of the medical staff, physical, dietary, and/or pharmacological management which could include treatments with topical over-the-counter myorelaxants to prevent and/or reduce muscle contractures. MyotonPro was used to daily measure tone, stiffness, and elasticity in RF and BF in relaxed and contracted state after every stage. In parallel, BF and RF soreness was also assessed with a Likert scale.All athletes received the same general massage management; none of them received dietary supplements; some of the athletes were treated with a topical myorelaxant thiocolchicoside (TCC 0.25%) foam 3 times daily. TCC was identified as the only variable able to affect these muscle parameters in the cyclists. Tone, stiffness (regardless of the state), and soreness significantly increased over time either in BF or RF in all athletes. In the group of athletes that used TCC (n = 11; TCC+) the increase in tone, stiffness, and soreness was significantly lower than in the group not receiving TCC (n = 12; No-TCC). Elasticity varied coherently with tone and stiffness.A very intense and protracted sport activity increases muscular tone, stiffness, and

  18. In response to 'Can sugars be produced from fatty acids? A test case for pathway analysis tools'.

    Science.gov (United States)

    Faust, Karoline; Croes, Didier; van Helden, Jacques

    2009-12-01

    In their article entitled 'Can sugars be produced from fatty acids? A test case for pathway analysis tools' de Figueiredo and co-authors assess the performance of three pathway prediction tools (METATOOL, PathFinding and Pathway Hunter Tool) using the synthesis of glucose-6-phosphate (G6P) from acetyl-CoA in humans as a test case. We think that this article is biased for three reasons: (i) the metabolic networks used as input for the respective tools were of very different sizes; (ii) the 'assessment' is restricted to two study cases; (iii) developers are inherently more skilled to use their own tools than those developed by other people. We extended the analyses led by de Figueiredo and clearly show that the apparent superior performance of their tool (METATOOL) is partly due to the differences in input network sizes. We also see a conceptual problem in the comparison of tools that serve different purposes. In our opinion, metabolic path finding and elementary mode analysis are answering different biological questions, and should be considered as complementary rather than competitive approaches. Supplementary data are available at Bioinformatics online.

  19. Towards a suite of test cases and a pycomodo library to assess and improve numerical methods in ocean models

    Science.gov (United States)

    Garnier, Valérie; Honnorat, Marc; Benshila, Rachid; Boutet, Martial; Cambon, Gildas; Chanut, Jérome; Couvelard, Xavier; Debreu, Laurent; Ducousso, Nicolas; Duhaut, Thomas; Dumas, Franck; Flavoni, Simona; Gouillon, Flavien; Lathuilière, Cyril; Le Boyer, Arnaud; Le Sommer, Julien; Lyard, Florent; Marsaleix, Patrick; Marchesiello, Patrick; Soufflet, Yves

    2016-04-01

    The COMODO group (http://www.comodo-ocean.fr) gathers developers of global and limited-area ocean models (NEMO, ROMS_AGRIF, S, MARS, HYCOM, S-TUGO) with the aim to address well-identified numerical issues. In order to evaluate existing models, to improve numerical approaches and methods or concept (such as effective resolution) to assess the behavior of numerical model in complex hydrodynamical regimes and to propose guidelines for the development of future ocean models, a benchmark suite that covers both idealized test cases dedicated to targeted properties of numerical schemes and more complex test case allowing the evaluation of the kernel coherence is proposed. The benchmark suite is built to study separately, then together, the main components of an ocean model : the continuity and momentum equations, the advection-diffusion of the tracers, the vertical coordinate design and the time stepping algorithms. The test cases are chosen for their simplicity of implementation (analytic initial conditions), for their capacity to focus on a (few) scheme or part of the kernel, for the availability of analytical solutions or accurate diagnoses and lastly to simulate a key oceanic processus in a controlled environment. Idealized test cases allow to verify properties of numerical schemes advection-diffusion of tracers, - upwelling, - lock exchange, - baroclinic vortex, - adiabatic motion along bathymetry, and to put into light numerical issues that remain undetected in realistic configurations - trajectory of barotropic vortex, - interaction current - topography. When complexity in the simulated dynamics grows up, - internal wave, - unstable baroclinic jet, the sharing of the same experimental designs by different existing models is useful to get a measure of the model sensitivity to numerical choices (Soufflet et al., 2016). Lastly, test cases help in understanding the submesoscale influence on the dynamics (Couvelard et al., 2015). Such a benchmark suite is an interesting

  20. ORNL results for Test Case 1 of the International Atomic Energy Agency's research program on the safety assessment of Near-Surface Radioactive Waste Disposal Facilities

    International Nuclear Information System (INIS)

    Thorne, D.J.; McDowell-Boyer, L.M.; Kocher, D.C.; Little, C.A.; Roemer, E.K.

    1993-01-01

    The International Atomic Energy Agency (IAEA) started the Coordinated Research Program entitled '''The Safety Assessment of Near-Surface Radioactive Waste Disposal Facilities.'' The program is aimed at improving the confidence in the modeling results for safety assessments of waste disposal facilities. The program has been given the acronym NSARS (Near-Surface Radioactive Waste Disposal Safety Assessment Reliability Study) for ease of reference. The purpose of this report is to present the ORNL modeling results for the first test case (i.e., Test Case 1) of the IAEA NSARS program. Test Case 1 is based on near-surface disposal of radionuclides that are subsequently leached to a saturated-sand aquifer. Exposure to radionuclides results from use of a well screened in the aquifer and from intrusion into the repository. Two repository concepts were defined in Test Case 1: a simple earth trench and an engineered vault

  1. Feminist Scholarship and Its Relevance for Political Engagement: The Test Case of Abortion in the U.S.

    Directory of Open Access Journals (Sweden)

    Margaret Kamitsuka

    2011-08-01

    Full Text Available This essay explores how gender studies in academe, including in religious studies, might remain relevant to ongoing feminist political engagement.  I explore some specific dynamics of this challenge, using as my test case the issue of abortion in the U.S.  After discussing how three formative feminist principles (women’s experience as feminism’s starting point, the personal is political, and identity politics have shaped approaches to the abortion issue for feminist scholars in religion, I argue that ongoing critique, new theoretical perspectives, and attentiveness to subaltern voices are necessary for these foundational feminist principles to keep pace with fast-changing and complex societal dynamics relevant to women’s struggles for reproductive health and justice.  The essay concludes by proposing ‘natality’ as a helpful concept for future feminist theological and ethical thinking on the subject.

  2. The International intraval project. Phase 1, test case 13: Experimental study of brine transport in porous media

    International Nuclear Information System (INIS)

    Glasbergen, P.

    1992-01-01

    INTRAVAL is an international coordinated research program for predicting the potential radionuclide migration in the geosphere with the use of mathematical models. Such models are used to help assess the long-term safety of radioactive waste disposal systems. This report describes the findings of the project teams involved in test case 13 of INTRAVAL Phase 1. The test case is based on laboratory experiments dealing with flow and dispersion of brine in a porous medium. The purpose of these experiments was twofold : (i) to investigate some of the relevant processes in brine transport in porous media, and (ii) to provide sets of data to be used for (partial) validation of transport models. The experiments were carried out in a column packed with glass beads of diameter 0.40 to 0.52 mm. Salt water was injected through nine holes at the bottom and withdrawn through nine holes at the top. Initially a low salt concentration was used which was then displaced with higher concentrated salt water. The salt mass-fraction was detected using an array of electrodes such that breakthrough curves were obtained at five different levels in the column. The report reviews a number of conceptual models and the corresponding numerical codes employed by different modelling teams. The experiments on one- and two-dimensional flow and transport were simulated by various groups. The question underlying the experiments, namely the applicability of Fick's laws over the whole range of salt concentration, could be addressed satisfactorily. All models could simulate low-concentration experiment using a dispersivity value of 0.8 mm to 1.00 mm. However, using the same dispersivity value, it was not possible to simulate high concentration experiments. Another question intended to be studied by the experiments was the validity of Darcy's law at high concentrations. Two-dimensional experiments were carried out for this purpose. In practice, calculations were hampered by extremely high demand on

  3. Validation of transport models for use in repository performance assessments: a view illustrated for INTRAVAL test case 1b

    International Nuclear Information System (INIS)

    Jackson, C.P.; Lever, D.A.; Sumner, P.J.

    1991-03-01

    We present our views on validation. We consider that validation is slightly different for general models and specific models. We stress the importance of presenting for review the case for (or against) a model. We outline a formal framework for validation, which helps to ensure that all the issues are addressed. Our framework includes calibration, testing predictions, comparison with alternative models, which we consider particularly important, analysis of discrepancies, presentation, consideration of implications and suggested improved experiments. We illustrate the approach by application to an INTRAVAL test case based on laboratory experiments. Three models were considered: a simple model that included the effects of advection, dispersion and equilibrium sorption, a model that also included the effects of rock-matrix diffusion, and a model with kinetic sorption. We show that the model with rock-matrix diffusion is the only one to provide a good description of the data. We stress the implications of extrapolating to larger length and time scales for repository performance assessments. (author)

  4. What's in a voice? Prosody as a test case for the Theory of Mind account of autism.

    Science.gov (United States)

    Chevallier, Coralie; Noveck, Ira; Happé, Francesca; Wilson, Deirdre

    2011-02-01

    The human voice conveys a variety of information about people's feelings, emotions and mental states. Some of this information relies on sophisticated Theory of Mind (ToM) skills, whilst others are simpler and do not require ToM. This variety provides an interesting test case for the ToM account of autism, which would predict greater impairment as ToM requirements increase. In this paper, we draw on psychological and pragmatic theories to classify vocal cues according to the amount of mindreading required to identify them. Children with a high functioning Autism Spectrum Disorder and matched controls were tested in three experiments where the speakers' state had to be extracted from their vocalizations. Although our results confirm that people with autism have subtle difficulties dealing with vocal cues, they show a pattern of performance that is inconsistent with the view that atypical recognition of vocal cues is caused by impaired ToM. Copyright © 2010 Elsevier Ltd. All rights reserved.

  5. Downscale cascades in tracer transport test cases: an intercomparison of the dynamical cores in the Community Atmosphere Model CAM5

    Directory of Open Access Journals (Sweden)

    J. Kent

    2012-12-01

    Full Text Available The accurate modeling of cascades to unresolved scales is an important part of the tracer transport component of dynamical cores of weather and climate models. This paper aims to investigate the ability of the advection schemes in the National Center for Atmospheric Research's Community Atmosphere Model version 5 (CAM5 to model this cascade. In order to quantify the effects of the different advection schemes in CAM5, four two-dimensional tracer transport test cases are presented. Three of the tests stretch the tracer below the scale of coarse resolution grids to ensure the downscale cascade of tracer variance. These results are compared with a high resolution reference solution, which is simulated on a resolution fine enough to resolve the tracer during the test. The fourth test has two separate flow cells, and is designed so that any tracer in the western hemisphere should not pass into the eastern hemisphere. This is to test whether the diffusion in transport schemes, often in the form of explicit hyper-diffusion terms or implicit through monotonic limiters, contains unphysical mixing.

    An intercomparison of three of the dynamical cores of the National Center for Atmospheric Research's Community Atmosphere Model version 5 is performed. The results show that the finite-volume (CAM-FV and spectral element (CAM-SE dynamical cores model the downscale cascade of tracer variance better than the semi-Lagrangian transport scheme of the Eulerian spectral transform core (CAM-EUL. Each scheme tested produces unphysical mass in the eastern hemisphere of the separate cells test.

  6. Toward Semi-automated Assessment of Target Volume Delineation in Radiotherapy Trials: The SCOPE 1 Pretrial Test Case

    Energy Technology Data Exchange (ETDEWEB)

    Gwynne, Sarah, E-mail: Sarah.Gwynne2@wales.nhs.uk [Department of Clinical Oncology, Velindre Cancer Centre, Cardiff, Wales (United Kingdom); Spezi, Emiliano; Wills, Lucy [Department of Medical Physics, Velindre Cancer Centre, Cardiff, Wales (United Kingdom); Nixon, Lisette; Hurt, Chris [Wales Cancer Trials Unit, School of Medicine, Cardiff University, Cardiff, Wales (United Kingdom); Joseph, George [Department of Diagnostic Radiology, Velindre Cancer Centre, Cardiff, Wales (United Kingdom); Evans, Mererid [Department of Clinical Oncology, Velindre Cancer Centre, Cardiff, Wales (United Kingdom); Griffiths, Gareth [Wales Cancer Trials Unit, School of Medicine, Cardiff University, Cardiff, Wales (United Kingdom); Crosby, Tom [Department of Clinical Oncology, Velindre Cancer Centre, Cardiff, Wales (United Kingdom); Staffurth, John [Division of Cancer, School of Medicine, Cardiff University, Cardiff, Wales (United Kingdom)

    2012-11-15

    Purpose: To evaluate different conformity indices (CIs) for use in the analysis of outlining consistency within the pretrial quality assurance (Radiotherapy Trials Quality Assurance [RTTQA]) program of a multicenter chemoradiation trial of esophageal cancer and to make recommendations for their use in future trials. Methods and Materials: The National Cancer Research Institute SCOPE 1 trial is an ongoing Cancer Research UK-funded phase II/III randomized controlled trial of chemoradiation with capecitabine and cisplatin with or without cetuximab for esophageal cancer. The pretrial RTTQA program included a detailed radiotherapy protocol, an educational package, and a single mid-esophageal tumor test case that were sent to each investigator to outline. Investigator gross tumor volumes (GTVs) were received from 50 investigators in 34 UK centers, and CERR (Computational Environment for Radiotherapy Research) was used to perform an assessment of each investigator GTV against a predefined gold-standard GTV using different CIs. A new metric, the local conformity index (l-CI), that can localize areas of maximal discordance was developed. Results: The median Jaccard conformity index (JCI) was 0.69 (interquartile range, 0.62-0.70), with 14 of 50 investigators (28%) achieving a JCI of 0.7 or greater. The median geographical miss index was 0.09 (interquartile range, 0.06-0.16), and the mean discordance index was 0.27 (95% confidence interval, 0.25-0.30). The l-CI was highest in the middle section of the volume, where the tumor was bulky and more easily definable, and identified 4 slices where fewer than 20% of investigators achieved an l-CI of 0.7 or greater. Conclusions: The available CIs analyze different aspects of a gold standard-observer variation, with JCI being the most useful as a single metric. Additional information is provided by the l-CI and can focus the efforts of the RTTQA team in these areas, possibly leading to semi-automated outlining assessment.

  7. How Are Fishing Patterns and Fishing Communities Responding to Climate Change? A Test Case from the Northwest Atlantic

    Science.gov (United States)

    Young, T.; Fuller, E.; Coleman, K.; Provost, M.; Pinsky, M. L.; St Martin, K.

    2016-02-01

    We know climate is changing and fish are moving in response to those changes. But we understand less about how harvesters are responding to these changes in fish distribution and the ramifications of those changes for fishing communities. Ecological and evolutionary theory suggests that organisms must move, adapt, or die in response to environmental changes, and a related frame may be relevant for human harvesters in the face of climate change. Furthermore, research suggests that there may be a portfolio effect: a wider diversity of catch may buffer harvesters from some effects of climate change. To get at these questions, we explored changes in fishing patterns among commercial fishing communities in the northeast US from 1997-2014 using NOAA-collected logbook data. We found that communities using more mobile gear (large trawl vessels) demonstrated a greater range of latitudinal shift than communities using any other gear. Latitudinal shift was also inversely related to species diversity of catch and port latitude in those communities: southern communities that caught few species shifted dramatically northward, and northern communities that caught many species did not demonstrate marked latitudinal shifts. Those communities that demonstrated larger latitudinal shifts also demonstrated smaller changes in catch composition than their more stationary counterparts. We also found that vessels are indeed leaving many, but not all, fisheries in this region. These results suggest that harvesters are moving, adapting, and leaving fisheries, and that there does appear to be a portfolio effect, with catch diversity mediating some of these responses. While these changes in fishing patterns cannot all be directly attributed to climate change per se, marine fishes in this region are shifting north rapidly, as is expected under climate change. This study provides a valuable test case for exploring the potential ramifications of climate change on coastal socio-ecological systems.

  8. Toward Semi-automated Assessment of Target Volume Delineation in Radiotherapy Trials: The SCOPE 1 Pretrial Test Case

    International Nuclear Information System (INIS)

    Gwynne, Sarah; Spezi, Emiliano; Wills, Lucy; Nixon, Lisette; Hurt, Chris; Joseph, George; Evans, Mererid; Griffiths, Gareth; Crosby, Tom; Staffurth, John

    2012-01-01

    Purpose: To evaluate different conformity indices (CIs) for use in the analysis of outlining consistency within the pretrial quality assurance (Radiotherapy Trials Quality Assurance [RTTQA]) program of a multicenter chemoradiation trial of esophageal cancer and to make recommendations for their use in future trials. Methods and Materials: The National Cancer Research Institute SCOPE 1 trial is an ongoing Cancer Research UK-funded phase II/III randomized controlled trial of chemoradiation with capecitabine and cisplatin with or without cetuximab for esophageal cancer. The pretrial RTTQA program included a detailed radiotherapy protocol, an educational package, and a single mid-esophageal tumor test case that were sent to each investigator to outline. Investigator gross tumor volumes (GTVs) were received from 50 investigators in 34 UK centers, and CERR (Computational Environment for Radiotherapy Research) was used to perform an assessment of each investigator GTV against a predefined gold-standard GTV using different CIs. A new metric, the local conformity index (l-CI), that can localize areas of maximal discordance was developed. Results: The median Jaccard conformity index (JCI) was 0.69 (interquartile range, 0.62-0.70), with 14 of 50 investigators (28%) achieving a JCI of 0.7 or greater. The median geographical miss index was 0.09 (interquartile range, 0.06-0.16), and the mean discordance index was 0.27 (95% confidence interval, 0.25-0.30). The l-CI was highest in the middle section of the volume, where the tumor was bulky and more easily definable, and identified 4 slices where fewer than 20% of investigators achieved an l-CI of 0.7 or greater. Conclusions: The available CIs analyze different aspects of a gold standard–observer variation, with JCI being the most useful as a single metric. Additional information is provided by the l-CI and can focus the efforts of the RTTQA team in these areas, possibly leading to semi-automated outlining assessment.

  9. Presentation of test cases TC-2A, TC-2B, TC-2C, TC-2D - Twodimensional, incompressible, wall flows with separation

    DEFF Research Database (Denmark)

    Scheel Larsen, Poul

    1988-01-01

    The four test cases comprise the backfacing step at high Re-number (TC-2A) and low Re-number (TC-2B), a low Re-number boundary layer flow past a thin obstacle, fence-on-wall (TC-2C), and a high Re-number developed channel flow past a squareobstacle (TC-2D). Geometry, test conditions and available...

  10. A Test Case for the Source Inversion Validation: The 2014 ML 5.5 Orkney, South Africa Earthquake

    Science.gov (United States)

    Ellsworth, W. L.; Ogasawara, H.; Boettcher, M. S.

    2017-12-01

    The ML5.5 earthquake of August 5, 2014 occurred on a near-vertical strike slip fault below abandoned and active gold mines near Orkney, South Africa. A dense network of surface and in-mine seismometers recorded the earthquake and its aftershock sequence. In-situ stress measurements and rock samples through the damage zone and rupture surface are anticipated to be available from the "Drilling into Seismogenic Zones of M2.0-M5.5 Earthquakes in South African gold mines" project (DSeis) that is currently progressing toward the rupture zone (Science, doi: 10.1126/science.aan6905). As of 24 July, 95% of drilled core has been recovered from a 427m-section of the 1st hole from 2.9 km depth with minimal core discing and borehole breakouts. A 2nd hole is planned to intersect the fault at greater depth. Absolute differential stress will be measured along the holes and frictional characteristics of the recovered core will be determined in the lab. Surface seismic reflection data and exploration drilling from the surface down to the mining horizon at 3km depth is also available to calibrate the velocity structure above the mining horizon and image reflective geological boundaries and major faults below the mining horizon. The remarkable quality and range of geophysical data available for the Orkney earthquake makes this event an ideal test case for the Source Inversion Validation community using actual seismic data to determine the spatial and temporal evolution of earthquake rupture. We invite anyone with an interest in kinematic modeling to develop a rupture model for the Orkney earthquake. Seismic recordings of the earthquake and information on the faulting geometry can be found in Moyer et al. (2017, doi: 10.1785/0220160218). A workshop supported by the Southern California Earthquake Center will be held in the spring of 2018 to compare kinematic models. Those interested in participating in the modeling exercise and the workshop should contact the authors for additional

  11. Real-life experience of using conventional disease-modifying anti-rheumatic drugs (DMARDs) in psoriatic arthritis (PsA). Retrospective analysis of the efficacy of methotrexate, sulfasalazine, and leflunomide in PsA in comparison to spondyloarthritides other than PsA and literature review of the use of conventional DMARDs in PsA

    Science.gov (United States)

    Roussou, Euthalia; Bouraoui, Aicha

    2017-01-01

    Objective With the aim of assessing the response to treatment with conventional disease-modifying anti-rheumatic drugs (DMARDs) used in patients with psoriatic arthritis (PsA), data on methotrexate, sulfasalazine (SSZ), and leflunomide were analyzed from baseline and subsequent follow-up (FU) questionnaires completed by patients with either PsA or other spondyloarthritides (SpAs). Material and Methods A single-center real-life retrospective analysis was performed by obtaining clinical data via questionnaires administered before and after treatment. The indices used were erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Function Index (BASFI), wellbeing (WB), and treatment effect (TxE). The indices measured at baseline were compared with those measured on one occasion in a FU visit at least 1 year later. Results A total of 73 patients, 51 with PsA (mean age 49.8±12.8 years; male-to-female ratio [M:F]=18:33) and 22 with other SpAs (mean age 50.6±16 years; M:F=2:20), were studied. BASDAI, BASFI, and WB displayed consistent improvements during FU assessments in both PsA patients and controls in comparison to baseline values. SSZ exhibited better efficacy as confirmed by TxE in both PsA patients and controls. ESR and CRP displayed no differences in either the PsA or the SpA group between the cases before and after treatment. Conclusion Real-life retrospective analysis of three DMARDs used in PsA (and SpAs other than PsA) demonstrated that all three DMARDs that were used brought about improvements in BASDAI, BASFI, TxE, and WB. However, the greatest improvements at FU were seen with SSZ use in both PsA and control cohorts. PMID:28293446

  12. Large-scale thermal convection of viscous fluids in a faulted system: 3D test case for numerical codes

    Science.gov (United States)

    Magri, Fabien; Cacace, Mauro; Fischer, Thomas; Kolditz, Olaf; Wang, Wenqing; Watanabe, Norihiro

    2017-04-01

    In contrast to simple homogeneous 1D and 2D systems, no appropriate analytical solutions exist to test onset of thermal convection against numerical models of complex 3D systems that account for variable fluid density and viscosity as well as permeability heterogeneity (e.g. presence of faults). Owing to the importance of thermal convection for the transport of energy and minerals, the development of a benchmark test for density/viscosity driven flow is crucial to ensure that the applied numerical models accurately simulate the physical processes at hands. The presented study proposes a 3D test case for the simulation of thermal convection in a faulted system that accounts for temperature dependent fluid density and viscosity. The linear stability analysis recently developed by Malkovsky and Magri (2016) is used to estimate the critical Rayleigh number above which thermal convection of viscous fluids is triggered. The numerical simulations are carried out using the finite element technique. OpenGeoSys (Kolditz et al., 2012) and Moose (Gaston et al., 2009) results are compared to those obtained using the commercial software FEFLOW (Diersch, 2014) to test the ability of widely applied codes in matching both the critical Rayleigh number and the dynamical features of convective processes. The methodology and Rayleigh expressions given in this study can be applied to any numerical model that deals with 3D geothermal processes in faulted basins as by example the Tiberas Basin (Magri et al., 2016). References Kolditz, O., Bauer, S., Bilke, L., Böttcher, N., Delfs, J. O., Fischer, T., U. J. Görke, T. Kalbacher, G. Kosakowski, McDermott, C. I., Park, C. H., Radu, F., Rink, K., Shao, H., Shao, H.B., Sun, F., Sun, Y., Sun, A., Singh, K., Taron, J., Walther, M., Wang,W., Watanabe, N., Wu, Y., Xie, M., Xu, W., Zehner, B., 2012. OpenGeoSys: an open-source initiative for numerical simulation of thermo-hydro-mechanical/chemical (THM/C) processes in porous media. Environmental

  13. The observing campaign on the deep-space debris WT1190F as a test case for short-warning NEO impacts

    Science.gov (United States)

    Micheli, Marco; Buzzoni, Alberto; Koschny, Detlef; Drolshagen, Gerhard; Perozzi, Ettore; Hainaut, Olivier; Lemmens, Stijn; Altavilla, Giuseppe; Foppiani, Italo; Nomen, Jaime; Sánchez-Ortiz, Noelia; Marinello, Wladimiro; Pizzetti, Gianpaolo; Soffiantini, Andrea; Fan, Siwei; Frueh, Carolin

    2018-04-01

    On 2015 November 13, the small artificial object designated WT1190F entered the Earth atmosphere above the Indian Ocean offshore Sri Lanka after being discovered as a possible new asteroid only a few weeks earlier. At ESA's SSA-NEO Coordination Centre we took advantage of this opportunity to organize a ground-based observational campaign, using WT1190F as a test case for a possible similar future event involving a natural asteroidal body.

  14. INTRAVAL Phase 2 WIPP 1 test case report: Modeling of brine flow through halite at the Waste Isolation Pilot Plant site

    International Nuclear Information System (INIS)

    Beauheim, R.L.

    1997-05-01

    This report describes the WIPP 1 test case studied as part of INTRAVAL, an international project to study validation of geosphere transport models. The WIPP 1 test case involved simulation of measured brine-inflow rates to boreholes drilled into the halite strata surrounding the Waste Isolation Pilot Plant repository. The goal of the test case was to evaluate the use of Darcy's law to describe brine flow through halite. The general approach taken was to try to obtain values of permeability and specific capacitance that would be: (1) consistent with other available data and (2) able to provide reasonable simulations of all of the brine-inflow experiments performed in the Salado Formation. All of the teams concluded that the average permeability of the halite strata penetrated by the holes was between approximately 10 -22 and 10 -21 m 2 . Specific capacitances greater than 10 -10 Pa -1 are inconsistent with the known constitutive properties of halite and are attributed to deformation, possibly ongoing, of the halite around the WIPP excavations. All project teams found that Darcy-flow models could replicate the experimental data in a consistent and reasonable manner. Discrepancies between the data and simulations are attributed to inadequate representation in the models of processes modifying the pore-pressure field in addition to the experiments themselves, such as ongoing deformation of the rock around the excavations. Therefore, the conclusion from the test case is that Darcy-flow models can reliably be used to predict brine flow to WIPP excavations, provided that the flow modeling is coupled with measurement and realistic modeling of the pore-pressure field around the excavations. This realistic modeling of the pore-pressure field would probably require coupling to a geomechanical model of the stress evolution around the repository

  15. The Image of the 1967 War in Israeli History Textbooks as Test Case: Studying an Active Past in a Protracted Regional Conflict

    Science.gov (United States)

    Yogev, Esther

    2012-01-01

    This article seeks to shed light on the dilemma facing history education in regions beset by a protracted, and as yet unresolved ethno-political conflict. The article will examine this issue by means of a unique test case that observes a dramatic war event in Israeli textbooks. The event in question is the Six-Day War of 1967 and the study of its…

  16. Exact Green's function method of solar force-free magnetic-field computations with constant alpha. I - Theory and basic test cases

    Science.gov (United States)

    Chiu, Y. T.; Hilton, H. H.

    1977-01-01

    Exact closed-form solutions to the solar force-free magnetic-field boundary-value problem are obtained for constant alpha in Cartesian geometry by a Green's function approach. The uniqueness of the physical problem is discussed. Application of the exact results to practical solar magnetic-field calculations is free of series truncation errors and is at least as economical as the approximate methods currently in use. Results of some test cases are presented.

  17. Método para generar casos de prueba funcional en el desarrollo de software Generating functional testing case method in software development

    Directory of Open Access Journals (Sweden)

    Liliana González Palacio

    2009-07-01

    Full Text Available Un aspecto crucial en el control de calidad del desarrollo de software son las pruebas y, dentro de estas, las pruebas funcionales, en las cuales se hace una verificación dinámica del comportamiento de un sistema, basada en la observación de un conjunto seleccionado de ejecuciones controladas o casos de prueba. Para hacer pruebas funcionales se requiere una planificación que consiste en definir los aspectos a chequear y la forma de verificar su correcto funcionamiento, punto en el cual adquieren sentido los casos de prueba. En este artículo derivado de investigación se define un método para generar casos de prueba funcional a partir de casos de uso del sistema, como producto intermedio del proyecto cofinanciado titulado "Herramienta para la documentación de pruebas funcionales"Testing is a main aspect in quality control of software development, especially functional tests. The aim of functional testing is to dynamically verify the system behavior, based on the observation of a given set of controlled executions or test cases. Planning is required to make functional tests, defining the aspects to be checked and the way to verify its proper operation; this allows test cases make sense. In this paper (research based, we propose a method to generate functional test cases from system use cases, based on the co-financed project "Tool for Documenting Functional Testing."

  18. Benchmark test cases for evaluation of computer-based methods for detection of setup errors: realistic digitally reconstructed electronic portal images with known setup errors

    International Nuclear Information System (INIS)

    Fritsch, Daniel S.; Raghavan, Suraj; Boxwala, Aziz; Earnhart, Jon; Tracton, Gregg; Cullip, Timothy; Chaney, Edward L.

    1997-01-01

    Purpose: The purpose of this investigation was to develop methods and software for computing realistic digitally reconstructed electronic portal images with known setup errors for use as benchmark test cases for evaluation and intercomparison of computer-based methods for image matching and detecting setup errors in electronic portal images. Methods and Materials: An existing software tool for computing digitally reconstructed radiographs was modified to compute simulated megavoltage images. An interface was added to allow the user to specify which setup parameter(s) will contain computer-induced random and systematic errors in a reference beam created during virtual simulation. Other software features include options for adding random and structured noise, Gaussian blurring to simulate geometric unsharpness, histogram matching with a 'typical' electronic portal image, specifying individual preferences for the appearance of the 'gold standard' image, and specifying the number of images generated. The visible male computed tomography data set from the National Library of Medicine was used as the planning image. Results: Digitally reconstructed electronic portal images with known setup errors have been generated and used to evaluate our methods for automatic image matching and error detection. Any number of different sets of test cases can be generated to investigate setup errors involving selected setup parameters and anatomic volumes. This approach has proved to be invaluable for determination of error detection sensitivity under ideal (rigid body) conditions and for guiding further development of image matching and error detection methods. Example images have been successfully exported for similar use at other sites. Conclusions: Because absolute truth is known, digitally reconstructed electronic portal images with known setup errors are well suited for evaluation of computer-aided image matching and error detection methods. High-quality planning images, such as

  19. Registration accuracy and quality of real-life images.

    Directory of Open Access Journals (Sweden)

    Wei-Yen Hsu

    Full Text Available BACKGROUND: A common registration problem for the application of consumer device is to align all the acquired image sequences into a complete scene. Image alignment requires a registration algorithm that will compensate as much as possible for geometric variability among images. However, images captured views from a real scene usually produce different distortions. Some are derived from the optic characteristics of image sensors, and others are caused by the specific scenes and objects. METHODOLOGY/PRINCIPAL FINDINGS: An image registration algorithm considering the perspective projection is proposed for the application of consumer devices in this study. It exploits a multiresolution wavelet-based method to extract significant features. An analytic differential approach is then proposed to achieve fast convergence of point matching. Finally, the registration accuracy is further refined to obtain subpixel precision by a feature-based modified Levenberg-Marquardt method. Due to its feature-based and nonlinear characteristic, it converges considerably faster than most other methods. In addition, vignette compensation and color difference adjustment are also performed to further improve the quality of registration results. CONCLUSIONS/SIGNIFICANCE: The performance of the proposed method is evaluated by testing the synthetic and real images acquired by a hand-held digital still camera and in comparison with two registration techniques in terms of the squared sum of intensity differences (SSD and correlation coefficient (CC. The results indicate that the proposed method is promising in registration accuracy and quality, which are statistically significantly better than other two approaches.

  20. Real-life C-RAN deployment considerations

    DEFF Research Database (Denmark)

    Hansen, Line Maria Pyndt; Ruepp, Sarah Renée; Christiansen, Henrik Lehrmann

    2017-01-01

    procedures and best practices for roll out are yet to be established. This work provides a case study, where a small but densely populated part of the network owned by the Danish mobile network operator, TDC, is evaluated for C-RAN deployment. A roadmap is provided which uses traffic data as input...

  1. Applications and real life spectra in the power generation industry

    International Nuclear Information System (INIS)

    Nix, K.J.; Lindley, T.C.

    1988-12-01

    Loading spectra encountered in various structures, machines, and components in the Power Generation Industry are presented from the viewpoint of fatigue analysis and structural integrity assessment. Although particular attention is paid to loading transients in turbo-generators, other items such as pressure vessels, pumped storage, nuclear plant pressure circuitry and wind turbines are also considered. (author)

  2. Redo log process mining in real life : data challenges & opportunities

    NARCIS (Netherlands)

    González López de Murillas, E.; Hoogendoorn, G.E.; Reijers, H.A.; Teniente, E.; Weidlich, M.

    2018-01-01

    Data extraction and preparation are the most time-consuming phases of any process mining project. Due to the variability on the sources of event data, it remains a highly manual process in most of the cases. Moreover, it is very difficult to obtain reliable event data in enterprise systems that are

  3. The Analysis of a Real Life Declarative Process

    DEFF Research Database (Denmark)

    Debois, Søren; Slaats, Tijs

    2015-01-01

    This paper reports on a qualitative study of the use of declarative process notations used in a commercial setting. Specifically, we investigate the actual use of a system implemented in terms of DCR graphs for the Danish "Dreyer Foundation" by our industry partner Exformatics A/S. The study...... by the declarative model, and (2) use process discovery techniques to examine if a perfect-fitness flow-based model representing the main business constraints is in fact easy to come by. For (1), we find evidence in various forms, most notably an apparent change in best practices by end-users allowed by the model....... For (2), we find no such model. We leave as a challenge to the community the construction of a flow-based model adequately representing the business constraints and supporting all observed behaviour by the users, whether by hand or by mining....

  4. Smart information systems computational intelligence for real-life applications

    CERN Document Server

    Hopfgartner, Frank

    2015-01-01

    This must-read text/reference presents an overview of smart information systems for both the private and public sector, highlighting the research questions that can be studied by applying computational intelligence. The book demonstrates how to transform raw data into effective smart information services, covering the challenges and potential of this approach. Each chapter describes the algorithms, tools, measures and evaluations used to answer important questions. This is then further illustrated by a diverse selection of case studies reflecting genuine problems faced by SMEs, multinational

  5. Real Life Science with Dandelions and Project BudBurst

    Directory of Open Access Journals (Sweden)

    Katherine A. Johnson

    2015-12-01

    Full Text Available Project BudBurst is a national citizen-science project that tracks bloom times and other phenological data for plants across the country. Data from Project BudBurst are being used to measure the effects of climate change. Students can participate in this project by watching any of the plants on the list, including the common dandelion, which makes the program easy and accessible to everyone.

  6. Torsional Topological Invariants (and their relevance for real life)

    CERN Document Server

    Chandia, O; Chandia, Osvaldo; Zanelli, Jorge

    1997-01-01

    The existence of topological invariants analogous to Chern/Pontryagin classes for a standard $SO(D)$ or SU(N) connection, but constructed out of the torsion tensor, is discussed. These invariants exhibit many of the features of the Chern/Pontryagin invariants: they can be expressed as integrals over the manifold of local densities and take integer values on compact spaces without boundary; their spectrum is determined by the homotopy groups determined by the connection bundle but depend also on the bundle of local orthonormal frames on the tangent space of the manifold. It is shown that in spacetimes with nonvanishing torsion there can occur topologically stable configurations associated with the frame bundle which are independent of the curvature. Explicit examples of topologically stable configurations carrying nonvanishing instanton number in four and eight dimensions are given, and they can be conjectured to exist in dimension $4k$. It is also shown that the chiral anomaly in a spacetime with torsion rece...

  7. Mangling the models: Real-life experiences in voluntary siting

    International Nuclear Information System (INIS)

    Roche, C.S.

    1993-01-01

    Social scientists are accumulating a growing body of research to guide the development of communications models for siting controversial facilities. The models emphasize building consensus by involving all stakeholders, including opponents, in the decision-making process from its earliest stages. Communications should focus on issues and concerns that are most relevant to the people in the involved community. Finally, trust must be built through local control of the decision-making process. This paper presents experiences in the voluntary siting process for the Monitored Retrievable Storage (MRS) facility for spent nuclear fuel in three locations: Grant County, North Dakota, Fremont County, Wyoming, and the Mescalero Apache nation in New Mexico

  8. Assessment of Automated Driving Systems using real-life scenarios

    NARCIS (Netherlands)

    Gelder, E. de; Paardekooper, J.P.

    2017-01-01

    More and more Advanced Driver Assistance Systems (ADAS) are entering the market for improving both safety and comfort by assisting the driver with their driving task. An important aspect in developing future ADAS and Automated Driving Systems (ADS) is testing and validation. Validating the failure

  9. Real life treatment of diabetes mellitus type 2 patients

    DEFF Research Database (Denmark)

    Wilke, Thomas; Groth, Antje; Fuchs, Andreas

    2014-01-01

    results. METHODS: We included all T2DM patients insured by a large sickness fund in 2010/2011. We defined 12 subgroups according to observed HbA1C, blood pressure and Charlson Comorbidity Index (CCI). For each subgroup, available sociodemographic and clinical information were reported. Different treatment...... variables were described. T2DM-related events leading to acute hospitalisations were reported. RESULTS: We included 394,828 T2DM patients in our analysis; for 228,703 patients' detailed data as basis for subgroup classification were available. For 4.5% of these patients, a HbA1C >9% was observed. 21...

  10. Cervical and facial infections - a real life threat

    Science.gov (United States)

    Rosu, S.; Fratila, M.

    2014-03-01

    Cervicofacial infections of dental origin are a difficult and complex issue of oral and maxillofacial surgery. Recognizing in due time the situations which are likely to develop a life-threatening condition and medical surgical prompt interventions significantly reduce the rate of the complications. Between January 2009 and March 2013, at the Clinic of Oral and Maxillofacial Surgery of the University of Medicine and Pharmacy "Victor Babes" Timisoara, 17 patients with severe cervicofacial infections were admitted in the emergency department as they needed a complex medical surgical treatment in accordance with protocol established together with the intensive-care department. Assessing the situations, we noticed a difficult, prolonged time of the recovery process which needed a hospitalization period of around 20 days. It recorded two deceased because of cervical necrotizing fasciitis and oral floor phlegmon, the most severe forms of the cervicofacial infections. The severity of the condition of the patients with cervicofacial infections must be figured and as quickly as possible an energetic therapeutic attitude must be adopted. The experience shows a frequent resistance to antibiotics like ampicillin, penicillin and oxacillin. The patients must be guided in due time to a clinic which has an intensive care department, where the surgical treatment must be administrated together with an intensive treatment for supporting the general condition. The reduction of the vital risk of the cervicofacial infections of dental origin will be done through an attentive assessment of the general and local condition (status) of the outpatients, before the dental extraction. The absence of a treatment adapted to the situation and to the clinic development, meaningfully increases the rate of the complications and the length of the hospitalization, the lethal evolution being not excluded.

  11. Cervical and facial infections – a real life threat

    International Nuclear Information System (INIS)

    Victor Babeş Timişoara, Piaţa Eftimie Murgu No. 2, 300041 (Romania))" data-affiliation=" (Maxillo-facial surgeon University of Medicine and Pharmacy Victor Babeş Timişoara, Piaţa Eftimie Murgu No. 2, 300041 (Romania))" >Rosu, S; Victor Babeş Timişoara, Piaţa Eftimie Murgu No. 2, 300041 (Romania))" data-affiliation=" (Maxillo-facial surgeon University of Medicine and Pharmacy Victor Babeş Timişoara, Piaţa Eftimie Murgu No. 2, 300041 (Romania))" >Fratila, M

    2014-01-01

    Cervicofacial infections of dental origin are a difficult and complex issue of oral and maxillofacial surgery. Recognizing in due time the situations which are likely to develop a life-threatening condition and medical surgical prompt interventions significantly reduce the rate of the complications. Between January 2009 and March 2013, at the Clinic of Oral and Maxillofacial Surgery of the University of Medicine and Pharmacy ''Victor Babes'' Timisoara, 17 patients with severe cervicofacial infections were admitted in the emergency department as they needed a complex medical surgical treatment in accordance with protocol established together with the intensive-care department. Assessing the situations, we noticed a difficult, prolonged time of the recovery process which needed a hospitalization period of around 20 days. It recorded two deceased because of cervical necrotizing fasciitis and oral floor phlegmon, the most severe forms of the cervicofacial infections. The severity of the condition of the patients with cervicofacial infections must be figured and as quickly as possible an energetic therapeutic attitude must be adopted. The experience shows a frequent resistance to antibiotics like ampicillin, penicillin and oxacillin. The patients must be guided in due time to a clinic which has an intensive care department, where the surgical treatment must be administrated together with an intensive treatment for supporting the general condition. The reduction of the vital risk of the cervicofacial infections of dental origin will be done through an attentive assessment of the general and local condition (status) of the outpatients, before the dental extraction. The absence of a treatment adapted to the situation and to the clinic development, meaningfully increases the rate of the complications and the length of the hospitalization, the lethal evolution being not excluded

  12. Reel help for real life: Film therapy and beyond

    Directory of Open Access Journals (Sweden)

    Philippa Strong

    2015-05-01

    Full Text Available In this article the background, development, therapeutical value and praxis of film therapy in Christian counselling will be addressed. The second part of the article shows what the scenery beyond film therapy may look like and how this form of therapy may extend to other areas of digital and electronic media in the current counselling and pastoral care praxis. Postmodernity, as the context within which the society finds itself, is discussed, as well as the place of films in postmodernity. The important use and application of narratives in the postmodern era is discussed. Film therapy’s development as an outgrowth of bibliotherapy is explained. It is further shown how film therapy as a tool in the praxis of therapy may provide the ideal atmosphere for learning, enjoyment and edification. The scope of the article also reaches beyond the current use of film therapy by suggesting the use of other social and electronic media in a therapeutical way as an ever-increasing possibility. The article ends with some pointers in the use of film therapy.

  13. Tamsulosin: real life clinical experience in 19,365 patients

    NARCIS (Netherlands)

    Michel, M. C.; Bressel, H. U.; Mehlburger, L.; Goepel, M.

    1998-01-01

    OBJECTIVE: To compare the efficacy, global tolerability and blood pressure effects of tamsulosin (0.4 mg once daily) in subgroups of patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO). METHODS: Data from two open-label, observational studies (Study I:

  14. Authority Relations in Group Relations Conferences and in "Real Life"

    DEFF Research Database (Denmark)

    Visholm, Steen; Beck, Ulla Charlotte

    2014-01-01

    Om autoritetsrelationer på grupperelationskonferencer (Leicesterkonferencen, Tavistockkonferencer, arbejdskonferencer) og i virkeligheden. Ligner arbejdskonferencen andre organisationer i en sådan udstrækning, at læring herfra kan overføres - eller er det vigtigt at udvikle nye former for lærings...

  15. Mathematics and Engineering in Real Life through Mathematical Competitions

    Science.gov (United States)

    More, M.

    2018-01-01

    We bring out an experience of organizing mathematical competitions that can be used as a medium to motivate the student and teacher minds in new directions of thinking. This can contribute to fostering research, innovation and provide a hands-on experience of mathematical concepts with the real world. Mathematical competitions can be used to build…

  16. The cue is key : design for real-life remembering

    NARCIS (Netherlands)

    Hoven, van den E.A.W.H.; Eggen, J.H.

    2014-01-01

    This paper aims to put the memory cue in the spotlight. We will show how memory cues are incorporated in the area of interaction design. The focus will be on external memory cues: cues that exist outside the human mind but have an internal effect on memory reconstruction. Examples of external cues

  17. Physics in ;Real Life;: Accelerator-based Research with Undergraduates

    Science.gov (United States)

    Klay, J. L.

    All undergraduates in physics and astronomy should have access to significant research experiences. When given the opportunity to tackle challenging open-ended problems outside the classroom, students build their problem-solving skills in ways that better prepare them for the workplace or future research in graduate school. Accelerator-based research on fundamental nuclear and particle physics can provide a myriad of opportunities for undergraduate involvement in hardware and software development as well as ;big data; analysis. The collaborative nature of large experiments exposes students to scientists of every culture and helps them begin to build their professional network even before they graduate. This paper presents an overview of my experiences - the good, the bad, and the ugly - engaging undergraduates in particle and nuclear physics research at the CERN Large Hadron Collider and the Los Alamos Neutron Science Center.

  18. Biometric identification devices -- Laboratory testing vs. real life

    International Nuclear Information System (INIS)

    Ahrens, J.S.

    1997-01-01

    For over fifteen years Sandia National Laboratories has been involved in laboratory testing of biometric identification devices. The key concept of biometric identification devices is the ability for the system to identify some unique aspect of the individual rather than some object a person may be carrying or some password they are required to know. Tests were conducted to verify manufacturer's performance claims, to determine strengths/weaknesses of devices, and to determine devices that meet the US Department of energy's needs. However, during recent field installation, significantly different performance was observed than was predicted by laboratory tests. Although most people using the device believed it operated adequately, the performance observed was over an order of magnitude worse than predicted. The search for reasons behind this gap between the predicted and the actual performance has revealed many possible contributing factors. As engineers, the most valuable lesson to be learned from this experience is the value of scientists and engineers with (1) common sense, (2) knowledge of human behavior, (3) the ability to observe the real world, and (4) the capability to realize the significant differences between controlled experiments and actual installations

  19. When real life wind speed exceeds design wind assumptions

    Energy Technology Data Exchange (ETDEWEB)

    Winther-Jensen, M; Joergensen, E R [Risoe National Lab., Roskilde (Denmark)

    1999-03-01

    Most modern wind turbines are designed according to a standard or a set of standards to withstand the design loads with a defined survival probability. Mainly the loads are given by the wind conditions on the site defining the `design wind speeds`, normally including extreme wind speeds given as an average and a peak value. The extreme wind speeds are normally (e.g. in the upcoming IEC standard for wind turbine safety) defined as having a 50-year recurrence period. But what happens when the 100 or 10,000 year wind situation hits a wind turbine? Results on wind turbines of wind speeds higher than the extreme design wind speeds are presented based on experiences especially from the State of Gujarat in India. A description of the normal approach of designing wind turbines in accordance with the standards in briefly given in this paper with special focus on limitations and built-in safety levels. Based on that, other possibilities than just accepting damages on wind turbines exposed for higher than design wind speeds are mentioned and discussed. The presentation does not intend to give the final answer to this problem but is meant as an input to further investigations and discussions. (au)

  20. Real Life Science with Dandelions and Project BudBurst.

    Science.gov (United States)

    Johnson, Katherine A

    2016-03-01

    Project BudBurst is a national citizen-science project that tracks bloom times and other phenological data for plants across the country. Data from Project BudBurst are being used to measure the effects of climate change. Students can participate in this project by watching any of the plants on the list, including the common dandelion, which makes the program easy and accessible to everyone. Journal of Microbiology & Biology Education.

  1. Solid oxide fuel cells towards real life applications. Final report

    Energy Technology Data Exchange (ETDEWEB)

    2010-07-01

    Solid Oxide Fuel Cells offer a clean and efficient way of producing electricity and heat from a wide selection of fuels. The project addressed three major challenges to be overcome by the technology to make commercialisation possible. (1) At the cell level, increased efficiency combined with production cost reduction has been achieved through an optimization of the manufacturing processes, b) by using alternative raw materials with a lower purchase price and c) by introducing a new generation of fuel cells with reduced loss and higher efficiency. (2) At the stack level, production cost reduction is reduced and manufacturing capacity is increased through an optimization of the stack production. (3) At the system level, development of integrated hotbox concepts for the market segments distributed generation (DG), micro combined heat and power (mCHP), and auxiliary power units (APU) have been developed. In the mCHP segment, two concepts have been developed and validated with regards to market requirements and scalability. In the APU-segment, different types of reformers have been tested and it has been proven that diesel can be reformed through appropriate reformers. Finally, operation experience and feedback has been gained by deployment of stacks in the test facility at the H.C. OErsted Power Plant (HCV). This demonstration has been carried out in collaboration between TOFC and DONG Energy Power A/S (DONG), who has participated as a subcontractor to TOFC. The demonstration has given valuable knowledge and experience with design, start-up and operation of small power units connected to the grid and future development within especially the mCHP segment will benefit from this. In this report, the project results are described for each of the work packages in the project. (Author)

  2. Social norms and cooperation in real-life social dilemmas

    DEFF Research Database (Denmark)

    Thøgersen, John

    2008-01-01

    The hypothesis that injunctive and descriptive norms interact positively or synergistically to promote cooperation in social dilemmas is tested in the context of a survey study focusing on environmentally responsible behaviour. Measurement error and strong and positive correlations between the two...

  3. WOMEN AND ADVANCEMENT IN NEUROPSYCHOLOGY:REAL-LIFE LESSONS LEARNED

    Science.gov (United States)

    Hilsabeck, Robin C.; Martin, Eileen M.

    2013-01-01

    The number of women in neuropsychology has been increasing over the past 20 years while the number of women in senior and leadership positions within neuropsychology has not. The field of neuropsychology has much to gain by facilitating the advancement of women into leadership roles, including access to some of the brightest and creative minds in the field. The purpose of this article is to offer practical advice about how to overcome barriers and advance within neuropsychology. Suggestions for professional organizations, women, and mentors of women are provided that will likely benefit trainees and junior colleagues regardless of their gender. PMID:18841516

  4. Tactical asset allocation in a real-life setting

    OpenAIRE

    Hernæs, Vegard

    2014-01-01

    Masteroppgave i økonomi og administrasjon – Universitetet i Agder 2014 This thesis will test one of the most popular market-timing strategies, using the longest available data set ranging from 1857 to 2012. The market-timing strategy has already proven to deliver superior results in the period 1926-2012 in a back-test. Which is why, the performance of the period pre-1926 will be compared to the post-1926 performance in a back-test. The performance of the two periods is similar, but period ...

  5. Women and advancement in neuropsychology: real-life lessons learned.

    Science.gov (United States)

    Hilsabeck, Robin C; Martin, Eileen M

    2010-04-01

    The number of women in neuropsychology has been increasing over the past 20 years while the number of women in senior and leadership positions within neuropsychology has not. The field of neuropsychology has much to gain by facilitating the advancement of women into leadership roles, including access to some of the brightest and creative minds in the field. The purpose of this article is to offer practical advice about how to overcome barriers and advance within neuropsychology. Suggestions for professional organizations, women, and mentors of women are provided that will likely benefit trainees and junior colleagues regardless of their gender.

  6. Noninvasive Medical Tools for Evaluating Voiding Pattern in Real Life

    Directory of Open Access Journals (Sweden)

    Kwonsoo Chun

    2017-04-01

    Full Text Available Voiding dysfunction is a common disease that contributes to a lower quality of life and has an increased prevalence in the elderly population. Noninvasive and objective methods such as uroflowmetry (UFM and voiding diaries (VDs are essential for exact diagnosis and effective treatment of this condition because patients with different causes of voiding dysfunction can complain of the same lower urinary tract symptoms. Further, different treatment options can be determined based on the diagnosis made from these symptoms. In order to improve the quality of UFM and VDs and to provide a convenient testing environment, several advances have been made by previous investigators. In this study, we investigate the history and technological mechanisms of UFM and VDs. We also aim to review UFM from the viewpoint of clinical and at-home uses, including the recently proposed toilet-shaped UFM and electronic VDs.

  7. Management of adenovirus infection in patients after haematopoietic stem cell transplantation: State-of-the-art and real-life current approach: A position statement on behalf of the Infectious Diseases Working Party of the European Society of Blood and Marrow Transplantation.

    Science.gov (United States)

    Hiwarkar, Prashant; Kosulin, Karin; Cesaro, Simone; Mikulska, Malgorzata; Styczynski, Jan; Wynn, Robert; Lion, Thomas

    2018-05-01

    The important insights gained over the past years in diagnosis and treatment of invasive adenoviral infections provide new paradigms for the monitoring and clinical management of these life-threatening complications. A meeting was held to discuss and subsequently disseminate the current advances in our understanding of the aetiology/pathogenesis and future treatment options facilitating effective control or prevention of adenovirus-related diseases in the allogeneic haematopoietic stem cell transplant setting. Invited experts in the field discussed recent progress with leading members of the Infectious Diseases Working Party of the European Society of Blood and Marrow Transplantation at the "State-of-the-art" Meeting in Poznan, Poland, in October 2017. In this review article, the panel of experts presents a concise summary of the current evidence based on published data from the last 15 years and on recent achievements resulting from real-life practice. The present position statement reflects an expert opinion on current approaches to clinical management of adenovirus infections in patients undergoing allogeneic haematopoietic stem cell transplant and provides graded recommendations of the panel for diagnostic approaches and preemptive therapy reflecting the present state of knowledge. Copyright © 2018 John Wiley & Sons, Ltd.

  8. Use and Application of the SADRWMS Methodology and SAFRAN Tool on the Thailand Institute of Nuclear Technology (TINT) Radioactive Waste Management Facility. Test Case Results. 05 October 2011

    International Nuclear Information System (INIS)

    2015-01-01

    The purpose of this document is to describe the working procedure of the test case and to provide feedback on the application of the methodology described in DS284 and the SAFRAN tool. This report documents how the test case was performed, describes how the methodology and software tool were applied, and provides feedback on the use and application of the SAFRAN Tool. The aim of this document is to address the key elements of the safety assessment and to demonstrate their principle contents and roles within the overall context of the safety case. This is done with particular emphasis on investigating the role of the SAFRAN Tool in developing a safety case for facilities similar to the TINT Facility. It is intended that this report will be the first of a series of complimentary safety reports illustrating the use and application of the methodology prescribed in DS284 and the application of the SAFRAN tool to a range of predisposal radioactive waste management activities

  9. A comparison of geostatistically based inverse techniques for use in performance assessment analysis at the Waste Isolation Pilot Plant Site: Results from Test Case No. 1

    International Nuclear Information System (INIS)

    Zimmerman, D.A.; Gallegos, D.P.

    1993-10-01

    The groundwater flow pathway in the Culebra Dolomite aquifer at the Waste Isolation Pilot Plant (WIPP) has been identified as a potentially important pathway for radionuclide migration to the accessible environment. Consequently, uncertainties in the models used to describe flow and transport in the Culebra need to be addressed. A ''Geostatistics Test Problem'' is being developed to evaluate a number of inverse techniques that may be used for flow calculations in the WIPP performance assessment (PA). The Test Problem is actually a series of test cases, each being developed as a highly complex synthetic data set; the intent is for the ensemble of these data sets to span the range of possible conceptual models of groundwater flow at the WIPP site. The Test Problem analysis approach is to use a comparison of the probabilistic groundwater travel time (GWTT) estimates produced by each technique as the basis for the evaluation. Participants are given observations of head and transmissivity (possibly including measurement error) or other information such as drawdowns from pumping wells, and are asked to develop stochastic models of groundwater flow for the synthetic system. Cumulative distribution functions (CDFs) of groundwater flow (computed via particle tracking) are constructed using the head and transmissivity data generated through the application of each technique; one semi-analytical method generates the CDFs of groundwater flow directly. This paper describes the results from Test Case No. 1

  10. Guidelines for selecting codes for ground-water transport modeling of low-level waste burial sites. Volume 2. Special test cases

    International Nuclear Information System (INIS)

    Simmons, C.S.; Cole, C.R.

    1985-08-01

    This document was written for the National Low-Level Waste Management Program to provide guidance for managers and site operators who need to select ground-water transport codes for assessing shallow-land burial site performance. The guidance given in this report also serves the needs of applications-oriented users who work under the direction of a manager or site operator. The guidelines are published in two volumes designed to support the needs of users having different technical backgrounds. An executive summary, published separately, gives managers and site operators an overview of the main guideline report. Volume 1, titled ''Guideline Approach,'' consists of Chapters 1 through 5 and a glossary. Chapters 2 through 5 provide the more detailed discussions about the code selection approach. This volume, Volume 2, consists of four appendices reporting on the technical evaluation test cases designed to help verify the accuracy of ground-water transport codes. 20 refs

  11. Dependency Analysis Guidance. Nordic/German Working Group on Common cause Failure analysis. Phase 1 project report: Comparisons and application to test cases

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Guenter (RISA Sicherheitsanalysen GmbH (DE)); Jaenkaelae, Kalle (Fortum Nuclear Services Oy (FI)); Johanson, Gunnar; Lindberg, Sandra (ES Konsult, Stockholm (SE)); Knochenhauer, Michael (Relcon Scandpower AB, Stockholm (SE)); Schubert, Bernd (Vattenfall Europe (DE)); Vaurio, Jussi (Prometh Solutions (FI)); Wohlstein, Ralf (E.ON Kernkraft, Maschinentechnik (DE))

    2007-10-15

    This report is part of the reporting from the European Working Group on CCF analysis (EWG), including members from Finland, Germany and Sweden. The project is planned in two phases with a reporting and progress evaluation before initiation of the second phase. Phase 1: Comparisons and application to test cases (2006). Phase 2: Development of harmonized approach and applications (2007). This report summarizes the work during the 1st phase of the project, which included the following main tasks: Task 1: Survey of databases, Task 2: Survey of methods for classification and quantification of CCF-events and description of these methods. Task 3: Classify events for application, using different approaches as recommended above. Task 4: Draw conclusions for harmonization

  12. On a New Variance Reduction Technique: Neural Network Biasing-a Study of Two Test Cases with the Monte Carlo Code Tripoli4

    International Nuclear Information System (INIS)

    Dumonteil, E.

    2009-01-01

    Various variance-reduction techniques are used in Monte Carlo particle transport. Most of them rely either on a hypothesis made by the user (parameters of the exponential biasing, mesh and weight bounds for weight windows, etc.) or on a previous calculation of the system with, for example, a deterministic solver. This paper deals with a new acceleration technique, namely, auto-adaptative neural network biasing. Indeed, instead of using any a priori knowledge of the system, it is possible, at a given point in a simulation, to use the Monte Carlo histories previously simulated to train a neural network, which, in return, should be able to provide an estimation of the adjoint flux, used then for biasing the simulation. We will describe this method, detail its implementation in the Monte Carlo code Tripoli4, and discuss its results on two test cases. (author)

  13. Experimental comparison of the high-speed imaging performance of an EM-CCD and sCMOS camera in a dynamic live-cell imaging test case.

    Directory of Open Access Journals (Sweden)

    Hope T Beier

    Full Text Available The study of living cells may require advanced imaging techniques to track weak and rapidly changing signals. Fundamental to this need is the recent advancement in camera technology. Two camera types, specifically sCMOS and EM-CCD, promise both high signal-to-noise and high speed (>100 fps, leaving researchers with a critical decision when determining the best technology for their application. In this article, we compare two cameras using a live-cell imaging test case in which small changes in cellular fluorescence must be rapidly detected with high spatial resolution. The EM-CCD maintained an advantage of being able to acquire discernible images with a lower number of photons due to its EM-enhancement. However, if high-resolution images at speeds approaching or exceeding 1000 fps are desired, the flexibility of the full-frame imaging capabilities of sCMOS is superior.

  14. Dependency Analysis Guidance. Nordic/German Working Group on Common cause Failure analysis. Phase 1 project report: Comparisons and application to test cases

    International Nuclear Information System (INIS)

    Becker, Guenter; Jaenkaelae, Kalle; Johanson, Gunnar; Lindberg, Sandra; Knochenhauer, Michael; Sc hubert, Bernd; Vaurio, Jussi; Wohlstei n, Ralf

    2007-10-01

    This report is part of the reporting from the European Working Group on CCF analysis (EWG), including members from Finland, Germany and Sweden. The project is planned in two phases with a reporting and progress evaluation before initiation of the second phase. Phase 1: Comparisons and application to test cases (2006). Phase 2: Development of harmonized approach and applications (2007). This report summarizes the work during the 1st phase of the project, which included the following main tasks: Task 1: Survey of databases, Task 2: Survey of methods for classification and quantification of CCF-events and description of these methods. Task 3: Classify events for application, using different approaches as recommended above. Task 4: Draw conclusions for harmonization

  15. Simulation of Test Case B

    DEFF Research Database (Denmark)

    Skovgaard, M.; Nielsen, Peter V.

    This report shows the results of the simulations given in research item 1.19 (isothermal forced convection) within the work of International Energy Agency (lEA), Annex 20 subtask 1. The title of this work is "Air Flow within Buildings" and the working title for subtask 1 is "Room Air...

  16. Final Empirical Test Case Specification

    DEFF Research Database (Denmark)

    Kalyanova, Olena; Heiselberg, Per

    This document includes the empirical specification on the IEA task of evaluation building energy simulation computer programs for the Double Skin Facades (DSF) constructions. There are two approaches involved into this procedure, one is the comparative approach and another is the empirical one....

  17. Testing Cases under Title VII.

    Science.gov (United States)

    Rothschild, Michael; Werden, Gregory J.

    This paper discusses Congressional and judicial attempts to deal with the problem of employment practices which lead to discriminatory outcomes but which may not be discriminatory in intent. The use of paper and pencil tests as standards for hiring and promotion is focused on as an example of this type of employment practice. An historical account…

  18. Tools for Test Case Generation

    NARCIS (Netherlands)

    Belinfante, Axel; Frantzen, Lars; Schallhart, Christian; Broy, Manfred; Jonsson, Bengt; Katoen, Joost P.; Leucker, Martin; Pretschner, Alexander

    2005-01-01

    The preceding parts of this book have mainly dealt with test theory, aimed at improving the practical techniques which are applied by testers to enhance the quality of soft- and hardware systems. Only if these academic results can be efficiently and successfully transferred back to practice, they

  19. The implications of soil acidification on a future HLW repository. Pt 2. Influence on deep granitic groundwater. The Klipperaas study site as test case

    International Nuclear Information System (INIS)

    Wersin, P.; Bruno, J.; Laaksoharju, M.

    1994-05-01

    The effect of acidification on deep groundwater is assessed with a geochemical box model based on the STEADYQL code. The application of the model to the Klipperaas study site shows a remarkable agreement between observed and predicted groundwater composition and offers an adequate description of the geochemical evolution of the aquifer. Proton fluxes are shown to be controlled mainly by calcite weathering and organic carbon degradation processes. The impact of increased acidification is evaluated on the basis of various test cases and by including the soil compartment in the model framework. The results indicate that calcite weathering will be increased by a factor of two to three as a result of increased acidification. Furthermore, the calculations suggest that, once the powerful carbonate buffer is depleted, the buffer capacity is provided mainly by anaerobic respiration and ion exchange processes. Further ongoing acidic loading would lead to neutralization of alkalinity fluxes leaving the system with a very low buffering capacity towards fluctuations in proton fluxes. Estimation of time scales of aquifer acidification was assessed under the focus of calcite depletion with aid of two acidification scenarios. These predict a time range of 12400 to 370000 years for calcite depletion to take place down to 500 meters depth. It is suggested from inherent model assumptions that these estimated time scales are conservative. 53 refs

  20. The implications of soil acidification on a future HLW repository. Pt 2. Influence on deep granitic groundwater. The Klipperaas study site as test case.

    Energy Technology Data Exchange (ETDEWEB)

    Wersin, P; Bruno, J [MBT Tecnologia Ambiental, Cerdanyola (Spain); Laaksoharju, M [Geopoint AB, Spaanga (Sweden)

    1994-05-01

    The effect of acidification on deep groundwater is assessed with a geochemical box model based on the STEADYQL code. The application of the model to the Klipperaas study site shows a remarkable agreement between observed and predicted groundwater composition and offers an adequate description of the geochemical evolution of the aquifer. Proton fluxes are shown to be controlled mainly by calcite weathering and organic carbon degradation processes. The impact of increased acidification is evaluated on the basis of various test cases and by including the soil compartment in the model framework. The results indicate that calcite weathering will be increased by a factor of two to three as a result of increased acidification. Furthermore, the calculations suggest that, once the powerful carbonate buffer is depleted, the buffer capacity is provided mainly by anaerobic respiration and ion exchange processes. Further ongoing acidic loading would lead to neutralization of alkalinity fluxes leaving the system with a very low buffering capacity towards fluctuations in proton fluxes. Estimation of time scales of aquifer acidification was assessed under the focus of calcite depletion with aid of two acidification scenarios. These predict a time range of 12400 to 370000 years for calcite depletion to take place down to 500 meters depth. It is suggested from inherent model assumptions that these estimated time scales are conservative. 53 refs.

  1. A Combined Hydrological and Hydraulic Model for Flood Prediction in Vietnam Applied to the Huong River Basin as a Test Case Study

    Directory of Open Access Journals (Sweden)

    Dang Thanh Mai

    2017-11-01

    Full Text Available A combined hydrological and hydraulic model is presented for flood prediction in Vietnam. This model is applied to the Huong river basin as a test case study. Observed flood flows and water surface levels of the 2002–2005 flood seasons are used for model calibration, and those of the 2006–2007 flood seasons are used for validation of the model. The physically based distributed hydrologic model WetSpa is used for predicting the generation and propagation of flood flows in the mountainous upper sub-basins, and proves to predict flood flows accurately. The Hydrologic Engineering Center River Analysis System (HEC-RAS hydraulic model is applied to simulate flood flows and inundation levels in the downstream floodplain, and also proves to predict water levels accurately. The predicted water profiles are used for mapping of inundations in the floodplain. The model may be useful in developing flood forecasting and early warning systems to mitigate losses due to flooding in Vietnam.

  2. Regarding the use and misuse of retinal protonated Schiff base photochemistry as a test case for time-dependent density-functional theory

    Energy Technology Data Exchange (ETDEWEB)

    Valsson, Omar [Department of Chemistry and Applied Biosciences, ETH Zurich and Facoltà di Informatica, Instituto di Scienze Computationali, Università della Svizzera italiana, Via Giuseppe Buffi 13, CH-6900 Lugano (Switzerland); Filippi, Claudia, E-mail: c.filippi@utwente.nl [MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede (Netherlands); Casida, Mark E., E-mail: mark.casida@ujf-grenoble.fr [Laboratoire de Chimie Théorique, Département de Chimie Moléculaire (DCM), Institut de Chimie Moléculaire de Grenoble (ICMG), Université Joseph Fourier, Grenoble I, F-3801 Grenoble (France)

    2015-04-14

    The excited-state relaxation of retinal protonated Schiff bases (PSBs) is an important test case for biological applications of time-dependent (TD) density-functional theory (DFT). While well-known shortcomings of approximate TD-DFT might seem discouraging for application to PSB relaxation, progress continues to be made in the development of new functionals and of criteria allowing problematic excitations to be identified within the framework of TD-DFT itself. Furthermore, experimental and theoretical ab initio advances have recently lead to a revised understanding of retinal PSB photochemistry, calling for a reappraisal of the performance of TD-DFT in describing this prototypical photoactive system. Here, we re-investigate the performance of functionals in (TD-)DFT calculations in light of these new benchmark results, which we extend to larger PSB models. We focus on the ability of the functionals to describe primarily the early skeletal relaxation of the chromophore and investigate how far along the out-of-plane pathways these functionals are able to describe the subsequent rotation around formal single and double bonds. Conventional global hybrid and range-separated hybrid functionals are investigated as the presence of Hartree-Fock exchange reduces problems with charge-transfer excitations as determined by the Peach-Benfield-Helgaker-Tozer Λ criterion and by comparison with multi-reference perturbation theory results. While we confirm that most functionals cannot render the complex photobehavior of the retinal PSB, do we also observe that LC-BLYP gives the best description of the initial part of the photoreaction.

  3. The Noether-Lefschetz problem and gauge-group-resolved landscapes: F-theory on K3 × K3 as a test case

    Energy Technology Data Exchange (ETDEWEB)

    Braun, A.P. [Department of Mathematics, King’s College,London WC2R 2LS (United Kingdom); Kimura, Y. [Yukawa Institute for Theoretical Physics, Kyoto University,Kyoto 606-8502 (Japan); Watari, T. [Kavli Institute for the Physics and Mathematics of the Universe, University of Tokyo,Kashiwano-ha 5-1-5, 277-8583 (Japan)

    2014-04-07

    Four-form flux in F-theory compactifications not only stabilizes moduli, but gives rise to ensembles of string vacua, providing a scientific basis for a stringy notion of naturalness. Of particular interest in this context is the ability to keep track of algebraic information (such as the gauge group) associated with individual vacua while dealing with statistics. In the present work, we aim to clarify conceptual issues and sharpen methods for this purpose, using compactification on K3×K3 as a test case. Our first approach exploits the connection between the stabilization of complex structure moduli and the Noether-Lefschetz problem. Compactification data for F-theory, however, involve not only a four-fold (with a given complex structure) Y{sub 4} and a flux on it, but also an elliptic fibration morphism Y{sub 4}⟶B{sub 3}, which makes this problem complicated. The heterotic-F-theory duality indicates that elliptic fibration morphisms should be identified modulo isomorphism. Based on this principle, we explain how to count F-theory vacua on K3×K3 while keeping the gauge group information. Mathematical results reviewed/developed in our companion paper are exploited heavily. With applications to more general four-folds in mind, we also clarify how to use Ashok-Denef-Douglas’ theory of the distribution of flux vacua in order to deal with statistics of sub-ensembles tagged by a given set of algebraic/topological information. As a side remark, we extend the heterotic/F-theory duality dictionary on flux quanta and elaborate on its connection to the semistable degeneration of a K3 surface.

  4. Semiclassical modelling of finite-pulse effects on non-adiabatic photodynamics via initial condition filtering: The predissociation of NaI as a test case

    Energy Technology Data Exchange (ETDEWEB)

    Martínez-Mesa, Aliezer [Departmento de Física Teórica, Universidad de la Habana, San Lázaro y L, La Habana 10400 (Cuba); Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Strasse 24-25, D-14476 Potsdam-Golm (Germany); Saalfrank, Peter [Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Strasse 24-25, D-14476 Potsdam-Golm (Germany)

    2015-05-21

    Femtosecond-laser pulse driven non-adiabatic spectroscopy and dynamics in molecular and condensed phase systems continue to be a challenge for theoretical modelling. One of the main obstacles is the “curse of dimensionality” encountered in non-adiabatic, exact wavepacket propagation. A possible route towards treating complex molecular systems is via semiclassical surface-hopping schemes, in particular if they account not only for non-adiabatic post-excitation dynamics but also for the initial optical excitation. One such approach, based on initial condition filtering, will be put forward in what follows. As a simple test case which can be compared with exact wavepacket dynamics, we investigate the influence of the different parameters determining the shape of a laser pulse (e.g., its finite width and a possible chirp) on the predissociation dynamics of a NaI molecule, upon photoexcitation of the A(0{sup +}) state. The finite-pulse effects are mapped into the initial conditions for semiclassical surface-hopping simulations. The simulated surface-hopping diabatic populations are in qualitative agreement with the quantum mechanical results, especially concerning the subpicosend photoinduced dynamics, the main deviations being the relative delay of the non-adiabatic transitions in the semiclassical picture. Likewise, these differences in the time-dependent electronic populations calculated via the semiclassical and the quantum methods are found to have a mild influence on the overall probability density distribution. As a result, the branching ratios between the bound and the dissociative reaction channels and the time-evolution of the molecular wavepacket predicted by the semiclassical method agree with those computed using quantum wavepacket propagation. Implications for more challenging molecular systems are given.

  5. Real-Life Solutions to Real-Life Problems: Collaborating with a Non-Profit Foundation to Engage Honors Students in Applied Research

    Science.gov (United States)

    Stark, Emily

    2013-01-01

    Colleges and universities have long emphasized undergraduate research experiences as valuable activities for students. Collegiate honors programs in particular have embraced the role of student research as an integral experience for high-ability students, leading the way in developing the thesis-based model of undergraduate research that is…

  6. Jamaica: Test case for tropical deforestation

    Energy Technology Data Exchange (ETDEWEB)

    Eyre, L A

    1987-01-01

    Deforestation in Jamaica, according to the United Nations (FAO/UNEP) and other sources, is occurring at an annual rate of about tree percent. This is accepted by some Jamaican government agencies, but strongly disputed by others. The Ministry of Agriculture, in particular, claims that the national forested area is actually increasing rapidly. A survey of humid tropical forests in Jamaica, carried out by the author in 1986, indicates a 3.3 percent per annum rate of deforestation for 1980-1986. But, despite significant commercial lumber production, large clear fellings are rare and most modification of the forest is due to expansion of small-scale farming (including Cannabis sativa) and pastoral activity. The size of area cleared is most often 20 to 25 hectares. As uncontrolled deforestation is adversely affecting watersheds and inducing serious flooding some form of control and management is urgently required.

  7. Test Case RCM-3 Using CPS

    Science.gov (United States)

    2001-03-01

    influence We observe an important variation of the flame length with the ratio gas / liquid injected (Figure 6 and Figure 7). The flame length increases with...fraction, the flame length increases (Figure 7). This is due to the increase of the oxygen injection speed to obtain the correct amount of oxygen...influence of C, with have made calculation with an arbitrary value for a witch is 10-6 N / m. The flame length decrease with the surface tension

  8. INTRAVAL test case 1b - modelling results

    International Nuclear Information System (INIS)

    Jakob, A.; Hadermann, J.

    1991-07-01

    This report presents results obtained within Phase I of the INTRAVAL study. Six different models are fitted to the results of four infiltration experiments with 233 U tracer on small samples of crystalline bore cores originating from deep drillings in Northern Switzerland. Four of these are dual porosity media models taking into account advection and dispersion in water conducting zones (either tubelike veins or planar fractures), matrix diffusion out of these into pores of the solid phase, and either non-linear or linear sorption of the tracer onto inner surfaces. The remaining two are equivalent porous media models (excluding matrix diffusion) including either non-linear sorption onto surfaces of a single fissure family or linear sorption onto surfaces of several different fissure families. The fits to the experimental data have been carried out by Marquardt-Levenberg procedure yielding error estimates of the parameters, correlation coefficients and also, as a measure for the goodness of the fits, the minimum values of the χ 2 merit function. The effects of different upstream boundary conditions are demonstrated and the penetration depth for matrix diffusion is discussed briefly for both alternative flow path scenarios. The calculations show that the dual porosity media models are significantly more appropriate to the experimental data than the single porosity media concepts. Moreover, it is matrix diffusion rather than the non-linearity of the sorption isotherm which is responsible for the tailing part of the break-through curves. The extracted parameter values for some models for both the linear and non-linear (Freundlich) sorption isotherms are consistent with the results of independent static batch sorption experiments. From the fits, it is generally not possible to discriminate between the two alternative flow path geometries. On the basis of the modelling results, some proposals for further experiments are presented. (author) 15 refs., 23 figs., 7 tabs

  9. FORESIGHT TEST CASE CHILE: UNIACC UNIVERSITY

    Directory of Open Access Journals (Sweden)

    José Nicolás Vizcaya Carrillo

    2011-04-01

    Full Text Available it is true that all human activities today are capable of analysis and prospective projection, confirmed there are a number of areas of knowledge which are considered key to the development of mankind and therefore of each company in each country is to see the evolution of the relevant future. It is true that today there are hundreds of professional disciplines that are studied and are performed as day to day and that play important roles in the welfare and development of society and in particular if this trial will be analyzed in the development of techniques current looking for Chile.

  10. Safety assessment methodologies for near surface disposal facilities. Results of a co-ordinated research project (ISAM). Volume 1: Review and enhancement of safety assessment approaches and tools. Volume 2: Test cases

    International Nuclear Information System (INIS)

    2004-07-01

    For several decades, countries have made use of near surface facilities for the disposal of low and intermediate level radioactive waste. In line with the internationally agreed principles of radioactive waste management, the safety of these facilities needs to be ensured during all stages of their lifetimes, including the post-closure period. By the mid 1990s, formal methodologies for evaluating the long term safety of such facilities had been developed, but intercomparison of these methodologies had revealed a number of discrepancies between them. Consequently, in 1997, the International Atomic Energy Agency launched a Co-ordinated Research Project (CRP) on Improvement of Safety Assessment Methodologies for Near Surface Disposal Facilities (ISAM). The particular objectives of the CRP were to provide a critical evaluation of the approaches and tools used in post-closure safety assessment for proposed and existing near-surface radioactive waste disposal facilities, enhance the approaches and tools used and build confidence in the approaches and tools used. The CRP ran until 2000 and resulted in the development of a harmonized assessment methodology (the ISAM project methodology), which was applied to a number of test cases. Over seventy participants from twenty-two Member States played an active role in the project and it attracted interest from around seven hundred persons involved with safety assessment in seventy-two Member States. The results of the CRP have contributed to the Action Plan on the Safety of Radioactive Waste Management which was approved by the Board of Governors and endorsed by the General Conference in September 2001. Specifically, they contribute to Action 5, which requests the IAEA Secretariat to 'develop a structured and systematic programme to ensure adequate application of the Agency's waste safety standards', by elaborating on the Safety Requirements on 'Near Surface Disposal of Radioactive Waste' (Safety Standards Series No. WS-R-1) and

  11. Brief communication: Paleobiological inferences on the locomotor repertoire of extinct hominoids based on femoral neck cortical thickness: The fossil great ape hispanopithecus laietanus as a test-case study.

    Science.gov (United States)

    Pina, Marta; Alba, David M; Almécija, Sergio; Fortuny, Josep; Moyà-Solà, Salvador

    2012-09-01

    The relationship between femoral neck superior and inferior cortical thickness in primates is related to locomotor behavior. This relationship has been employed to infer bipedalism in fossil hominins, although bipeds share the same pattern of generalized quadrupeds, where the superior cortex is thinner than the inferior one. In contrast, knuckle-walkers and specialized suspensory taxa display a more homogeneous distribution of cortical bone. These different patterns, probably related to the range of movement at the hip joint and concomitant differences in the load stresses at the femoral neck, are very promising for making locomotor inferences in extinct primates. To evaluate the utility of this feature in the fossil record, we relied on computed tomography applied to the femur of the Late Miocene hominoid Hispanopithecus laietanus as a test-case study. Both an orthograde body plan and orang-like suspensory adaptations had been previously documented for this taxon on different anatomical grounds, leading to the hypothesis that this fossil ape should display a modern ape-like distribution of femoral neck cortical thickness. This is confirmed by the results of this study, leading to the conclusion that Hispanopithecus represents the oldest evidence of a homogeneous cortical bone distribution in the hominoid fossil record. Our results therefore strengthen the utility of femoral neck cortical thickness for making paleobiological inferences on the locomotor repertoire of fossil primates. This feature would be particularly useful for assessing the degree of orthograde arboreal locomotor behaviors vs. terrestrial bipedalism in putative early hominins. Copyright © 2012 Wiley Periodicals, Inc.

  12. Cost-effectiveness of newborn screening for cystic fibrosis determined with real-life data

    NARCIS (Netherlands)

    van der Ploeg, C. P B; van den Akker-van Marle, M. E.; Vernooij-van Langen, A. M M; Elvers, L. H.; Gille, J. J P; Verkerk, P. H.; Dankert-Roelse, J. E.; Dankert-Roelse, J. E.; Vernooij-van Langen, A. M M; Loeber, J. G.; Elvers, L. H.; Triepels, R. H.; Gille, J. J P; Van der Ploeg, C. P B; van der Pal, S. M.; Dompeling, E.; Pals, G.; van den Akker van Marle, M. E.; Gulmans, V. A M; Oey-Spauwen, M. J W; Wijnands, Y. H H M; Castricum, L. M.; Arets, H. G M; van der Ent, C. K.; Tiddens, H. A W M; de Rijke, Y. B.; Yntema, J. B.

    2015-01-01

    Background: Previous cost-effectiveness studies using data from the literature showed that newborn screening for cystic fibrosis (NBSCF) is a good economic option with positive health effects and longer survival. Methods: We used primary data to compare cost-effectiveness of four screening

  13. Emotion and the affective turn: Towards an integration of cognition and affect in real life experience

    Directory of Open Access Journals (Sweden)

    Cornel W. du Toit

    2014-11-01

    Full Text Available Emotion is caused by many factors, some of which are evolutionary, neurological, chemical, environmental, societal, personal and religious. Mostly, however, we are oblivious of the causal factors, many of which may function on a biological level or subconsciously, although the emotional effect is experienced physically and consciously. Emotions change as the trigger mechanisms in the cultural context change. This usually happens unnoticed over long periods. Internet databases have now made it possible to study the use of emotive words; this point is discussed. Of particular interest is the interaction between emotion and reason. Models that reduce emotion to the physical level are scrutinised critically. Reason is not emotionless and emotion is not always irrational. The close interrelationship of emotion and reason often makes it difficult to distinguish accurately between the two. The so-called affective turn takes cognisance of cultural, social, religious and other environmental factors; this broader approach clarifies the importance of affect’s role in rationality. One way of viewing emotion and affect is to look at the accompanying language; here the role of metaphor and narrative is pertinent. The traditional elevation of reason above emotion is examined critically as part of the affective turn that broadens the meaning and scope of emotions. I focus on the role of emotion in religion and factors that influence it, and explore the accent of affect in new spiritualities.

  14. Hipocrates (2014. Real life of a resident at a public hospital

    Directory of Open Access Journals (Sweden)

    Emilio PINTOR HOLGUIN

    2017-12-01

    Full Text Available It describes Benjamin´s first weeks of work as a new resident of Internal Medicine in a public hospital in Paris. Next to him, an experienced Algerian physician; Abdel, performs his practices of validation. Main problems with these two doctors are described: doubts, decision making, camaraderie, bioethical and liability problems as well as problems derived from public health system budgets. All mixed with short ironic and comic scenes that sometimes reach surrealism.

  15. It's Not Easy Being Green: Bringing Real Life to the Undergraduate Legal Environment of Business Classroom

    Science.gov (United States)

    Marcum, Tanya M.; Perry, Sandra J.

    2010-01-01

    In the Legal Environment of Business course in a traditional undergraduate business curriculum, students are expected to acquire knowledge about many areas of the law and the application of law to business, society, and the international marketplace. Current concepts in undergraduate business education, such as ethics and sustainability, must also…

  16. Real-life study showing better control of allergic rhinitis by immunotherapy than regular pharmacotherapy

    NARCIS (Netherlands)

    Droessaert, V.; Timmermans, M.; Dekimpe, E.; Seys, S.; Ceuppens, J. J.; Fokkens, W. J.; Hellings, P. W.

    2016-01-01

    Treatment for allergic rhinitis (AR) aims at reducing the burden of allergic inflammation, either by suppression of the nasal inflammation with pharmacotherapy or by inducing tolerance via immunotherapy (IT). At present, we lack information on the comparison between the degree of symptom control in

  17. Reidentification of Persons Using Clothing Features in Real-Life Video

    Directory of Open Access Journals (Sweden)

    Guodong Zhang

    2017-01-01

    Full Text Available Person reidentification, which aims to track people across nonoverlapping cameras, is a fundamental task in automated video processing. Moving people often appear differently when viewed from different nonoverlapping cameras because of differences in illumination, pose, and camera properties. The color histogram is a global feature of an object that can be used for identification. This histogram describes the distribution of all colors on the object. However, the use of color histograms has two disadvantages. First, colors change differently under different lighting and at different angles. Second, traditional color histograms lack spatial information. We used a perception-based color space to solve the illumination problem of traditional histograms. We also used the spatial pyramid matching (SPM model to improve the image spatial information in color histograms. Finally, we used the Gaussian mixture model (GMM to show features for person reidentification, because the main color feature of GMM is more adaptable for scene changes, and improve the stability of the retrieved results for different color spaces in various scenes. Through a series of experiments, we found the relationships of different features that impact person reidentification.

  18. Gold standard program for heavy smokers in a real-life setting

    DEFF Research Database (Denmark)

    Neumann, Tim; Rasmussen, Mette; Heitmann, Berit L

    2013-01-01

    Background: High-intensity smoking cessation programs generally lead to more continuous abstinence, however, lower rates of success have been reported among heavy smokers. The aim was to evaluate continuous abstinence among heavy smokers during the intensive 6-week Gold Standard Program (GSP......) and to identify modifiable factors associated with continuous abstinence. Methods: In this nationwide clinical study based on 36,550 smokers attending an intensive cessation program in Denmark. Heavy smoking was defined as ≥7 points in the Fagerström Nicotine Dependency Test, smoking ≥20 cigarettes daily or ≥20...... pack-years. Results: Overall, 28% had a Fagerström score ≥7 points, 58% smoked ≥20 cigarettes daily and 68% smoked ≥20 pack-years. Continuous abstinence was 33% in responders (6-months response rate: 78%); however, abstinence was approximately 1-6% lower in the heavy smokers than the overall population...

  19. Mental Procedures in Real-Life Tasks: A Case of Electronic Trouble Shooting

    DEFF Research Database (Denmark)

    Rasmussen, Jens; Jensen, A.

    1974-01-01

    be broken down into a sequence of recurrent search routines. Basically different typos of such routines are found with great differences in respect to the number of observations needed and the complexity of the mental data processing involved. They also differ greatly with respect to the depth of knowledge......The mental procedures used by skilled electronics repair men in their normal working environment have been studied by analysis of verbal protocols. The procedures found are organized as a search through a system which is viewed as a hierarchy of subunits. The general structure of the search can...... less of whether observations are informationally redundant or not. Seen from the viewpoint of information economy, the procedures are inefficient, but if the men are supposed to minimize the time spent ill the task and the mental load involved, the procedures are very rational. The records indicate...

  20. Vehicular ad hoc networks: From simulations to real-life scenarios

    African Journals Online (AJOL)

    pc

    2018-03-05

    Mar 5, 2018 ... Indeed, the introduction of new technologies and communication ... D2D communication technology to allow cars to communicate with each other, as well .... need for driver intervention will be adopted in 2019 [20]. Ultrasonic ...

  1. Radiological health risk evaluation of radium contaminated land: A real life implementation

    International Nuclear Information System (INIS)

    Paridaens, J.

    2005-01-01

    A plot of land, currently used for dairy farming, has been contaminated over the years with radium due to the operation of one of the world's largest radium production plants. Within the framework of a global remediation approach for the plant surroundings, the land owner needed advice for a future destination of the land. Therefore, the radium contamination was accurately mapped, and on the basis of its severity a practically feasible subdivision of the land into four plots was proposed. For all four plots, the radiological risk was evaluated for the current type of land use and for possible alternative types. Hence a clear and usable advice could be formulated to the authorities reconciling public health, economic and practical issues. (authors)

  2. Computational Chemistry Laboratory: Calculating the Energy Content of Food Applied to a Real-Life Problem

    Science.gov (United States)

    Barbiric, Dora; Tribe, Lorena; Soriano, Rosario

    2015-01-01

    In this laboratory, students calculated the nutritional value of common foods to assess the energy content needed to answer an everyday life application; for example, how many kilometers can an average person run with the energy provided by 100 g (3.5 oz) of beef? The optimized geometries and the formation enthalpies of the nutritional components…

  3. Optimized Design of Materialized Views in a Real-Life Data Warehousing Environment

    NARCIS (Netherlands)

    Chan, G.K.Y.; Gay, R.K.L.; Li, Q; Feng, L.

    In this paper, we describe the design of a data warehousing system for an engineering company ‘R’. This system aims to assist users in retrieving data for business analysis in an efficient manner. The structural design of this data warehousing system employs the dimensional modeling concepts of star

  4. Empirical Platform Data Analysis to Investigate how Heat Pumps Operate in Real-Life Conditions

    DEFF Research Database (Denmark)

    Carmo, Carolina; Elmegaard, Brian; Nielsen, M. P.

    2015-01-01

    Heat pumps have been widely acknowledged, by academia and industry, as highly efficient thermal energy technologies, for space heating and domestic hot water production. However, there is a lack of information about real performance in residential single family houses with active participation...... of end-users. In this paper, an analysis based on data from 242 heat pump installations in Denmark gathered over a period up to 4 years (2010 until today) is performed. COP, operating temperatures and socio-demographic data are used as basis for comparing theoretical and actual performance. Six different...... heat pump configurations are considered depending on source (ground or air) and sink (radiators, floor heating and/or combined systems). This unique study intends to point out the benefits and limitations of such technologies in terms of energy efficiency and comfort delivery, as well as investigating...

  5. Toward Virtual Campuses: Collaborative Virtual Labs & Personalized Learning Services in a Real-Life Context

    OpenAIRE

    Tsekeridou, Sofia; Tiropanis, Thanassis; Christou, Ioannis; Vakilzadeh, Haleh

    2008-01-01

    Virtual campuses are gradually becoming a reality with the advances in e-learning and Web technologies, distributed systems and broadband communication, as well as the emerging needs of remote Universities for collaboration on offering common programs. The advances in grid-based distributed infrastructures have further significantly contributed to this fact providing optimized and real-time system performance and support for virtual communities even under synchronous distributed multi-user us...

  6. Business Intelligence in College: A Teaching Case with Real Life Puzzles

    Science.gov (United States)

    Presthus, Wanda; Bygstad, Bendik

    2012-01-01

    Modern Business Intelligence (BI) is about the process of turning data into actionable information, using an assortment of tools, techniques, and applications. Although BI, or its predecessor Decision Support Systems (DSS), has been applied in the industry for about half a century, it has only recently been taught in business schools. In the…

  7. Real Life Narratives Enhance Learning about the "Art and Science" of Midwifery Practice

    Science.gov (United States)

    Gilkison, Andrea; Giddings, Lynne; Smythe, Liz

    2016-01-01

    Health professional educators have long grappled with how to teach the more elusive art of practice alongside the science (a term that encompasses the sort of professional knowledge that can be directly passed on). A competent practitioner is one who knows when, how and for whom to apply knowledge and skills, thereby making the links between…

  8. Bringing Abstract Academic Integrity and Ethical Concepts into Real-Life Situations

    Science.gov (United States)

    Kwong, Theresa; Wong, Eva; Yue, Kevin

    2017-01-01

    This paper reports the learning analytics on the initial stages of a large-scale, government-funded project which inducts university students in Hong Kong into consideration of academic integrity and ethics through mobile Augmented Reality (AR) learning trails--Trails of Integrity and Ethics (TIEs)--accessed on smart devices. The trails immerse…

  9. 3D Projection on Physical Objects: Design Insights from Five Real Life Cases

    DEFF Research Database (Denmark)

    Dalsgaard, Peter; Halskov, Kim

    2011-01-01

    3D projection on physical objects is a particular kind of Augmented Reality that augments a physical object by projecting digital content directly onto it, rather than by using a mediating device, such as a mobile phone or a head- mounted display. In this paper, we present five cases in which we...

  10. Something to talk about: Gossip increases oxytocin levels in a near real-life situation.

    Science.gov (United States)

    Brondino, Natascia; Fusar-Poli, Laura; Politi, Pierluigi

    2017-03-01

    Gossip is a pervasive social behavior. Its evolutionary survival seems related to its social functions, such as establishing group rules, punishing trespassers, exercising social influence through reputational systems, and developing and strengthening social bonds. We aimed at evaluating the effect of gossip on hormones (oxytocin and cortisol) and at identifying potential mediators of hormonal response to gossip. Twenty-two female students were randomly assigned to a gossip conversation or to an emotional non-gossip conversation. Additionally, all participants underwent a neutral conversation on the second day of the study. Salivary oxytocin and cortisol levels were measured. Oxytocin increased significantly in the gossip compared to the emotional non-gossip conversation. A decrease in cortisol levels was observed in all three conditions (gossip, emotional non-gossip, neutral). Change in cortisol levels was similar across conditions. Psychological characteristics (e.g. empathy, autistic traits, perceived stress, envy) did not affect oxytocin rise in the gossip condition. Our findings suggest that oxytocin may represent a potential hormonal correlate of gossip behavior. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Real Life Calls for Real Books: Literature to Help Children Cope with Family Stressors

    Science.gov (United States)

    Roberts, Sherron Killingsworth; Crawford, Patricia A.

    2008-01-01

    This article provides a rationale and related practical suggestions for using literature as a support system for social-emotional development as children cope with the stresses, anxieties, and feelings of loss that can occur in family life. The authors discusses types of books, how to choose them, and how teachers can use authentic literature to…

  12. Relating the Learned Knowledge and Acquired Skills to Real Life: Function Sample

    Science.gov (United States)

    Albayrak, Mustafa; Yazici, Nurullah; Simsek, Mertkan

    2017-01-01

    Considering that Mathematics is a multidimensional problem-solving method that can be effective in all areas of cultural life, it is of great importance because of its contribution to other sciences such as physical and social sciences. It is known that the basic concepts of mathematics, which can also be expressed as a way of life, have helped to…

  13. Designing high availability systems DFSS and classical reliability techniques with practical real life examples

    CERN Document Server

    Taylor, Zachary

    2014-01-01

    A practical, step-by-step guide to designing world-class, high availability systems using both classical and DFSS reliability techniques Whether designing telecom, aerospace, automotive, medical, financial, or public safety systems, every engineer aims for the utmost reliability and availability in the systems he, or she, designs. But between the dream of world-class performance and reality falls the shadow of complexities that can bedevil even the most rigorous design process. While there are an array of robust predictive engineering tools, there has been no single-source guide to understan

  14. Design and rationale of dabigatran's stroke prevention in real life in Turkey (D-SPIRIT).

    Science.gov (United States)

    Türk, Uğur Önsel; Alioğlu, Emin; Tunçer, Eşref; Özpelit, Mehmet Emre; Pekel, Nihat; Tengiz, İstemihan; Çetin, Nurullah; Dalgıç, Onur; Topaloğlu, Caner; Bilgin, Nazile; Altın, Cihan; Özdemirkıran, Tolga; Tülüce, Kamil; Türkoğlu, Ebru İpek; Özpelit, Ebru

    2016-04-01

    The D-SPIRIT registry is designed to investigate the safety and efficacy of dabigatran etexilate in patients with nonvalvular atrial fibrillation (NVAF) and to collect data on outcomes in clinical practice. The D-SPIRIT is a national, prospective, observational, post-marketing registry involving patients with NVAF who have been taking dabigatran etexilate therapy for stroke prevention for a minimum of 6 months prior to enrollment. The registry will collect and analyze data from routine care, enrolling up to 600 patients in 9 centers. Patients will be followed up for 2 years to evaluate effectiveness and safety. A sample size of 600 subjects is proposed based on the following assumptions; Two-sided significance level of 0.05 (1-sided significance level of 0.025), ischemic stroke incidence rate of 0.768%-1.111%, hemorrhagic stroke incidence rate of 0.109%-0.130%, transient ischemic attack incidence rate of 0.722%-0.623%, therapy discontinuation incidence rate of 40% at day 730, and duration of enrollment period of 12 months with non-uniformed enrollment rate. Ethics approval was given by Dokuz Eylül University Ethics Committee of Clinical Research (2014/54) and approved by the Turkish Ministry of Health. Potential results of D-SPIRIT registry will add data from clinical practice to those from the RE-LY trial to expand knowledge of dabigatran etexilate treatment in patients with NVAF.

  15. Hyperthyroidism association with SLE, lessons from real-life data--A case-control study.

    Science.gov (United States)

    Watad, Abdulla; Cohen, Arnon D; Comaneshter, Doron; Tekes-Manova, Dorit; Amital, Howard

    2016-01-01

    Despite the frequently encountered association between thyroid disease and systemic lupus erythematosus (SLE) is well known, it is of surprise that only several reports compromised of small population size support this observation. To investigate the association of comorbid SLE and hyperthyroidism. Using the database of the largest health maintenance organization (HMO) in Israel, the Clalit Health Services, we searched for the co-existence of SLE and hyperthyroidism. Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of hyperthyroidism in a case-control study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study included 5018 patients with SLE and 25,090 age- and sex- matched controls. The prevalence of hyperthyroidism in patients with SLE was increased compared with the prevalence in controls (2.59% and 0.91%, respectively, p hyperthyroidism (odds ratio 2.52, 95% confidence interval 2.028-3.137). Patients with SLE have a greater prevalence of hyperthyroidism than matched controls. Therefore, physicians treating patients with SLE should be aware of this possibility of this thyroid dysfunction.

  16. Explaining Real-Life Events: How Culture and Domain Shape Attributions.

    Science.gov (United States)

    Lee, Fiona; And Others

    1996-01-01

    Research has shown that attributional styles are affected by the attributor's culture, inferential goals, and level of cognitive processing. This study compares the attributions made in sports articles and editorials of newspapers published in Hong Kong and the United States. Implications for the mixed model of social inference are discussed. (LSR)

  17. Appraisal of and Coping with a Real-Life Stressful Situation: The Contribution of Attachment Styles.

    Science.gov (United States)

    Mikulincer, Mario; Florian, Victor

    1995-01-01

    Assessed ways attachment styles affect young adults' reactions to stressors associated with four-month combat training. Results show that, compared with secure trainees, ambivalent trainees reported more emotion-focused coping, appraised the training in more threatening terms, and considered themselves less capable of coping with the training.…

  18. The effect of a low-speed automatic brake system estimated from real life data.

    Science.gov (United States)

    Isaksson-Hellman, Irene; Lindman, Magdalena

    2012-01-01

    A substantial part of all traffic accidents involving passenger cars are rear-end collisions and most of them occur at low speed. Auto Brake is a feature that has been launched in several passenger car models during the last few years. City Safety is a technology designed to help the driver mitigate, and in certain situations avoid, rear-end collisions at low speed by automatically braking the vehicle.Studies have been presented that predict promising benefits from these kinds of systems, but few attempts have been made to show the actual effect of Auto Brake. In this study, the effect of City Safety, a standard feature on the Volvo XC60 model, is calculated based on insurance claims data from cars in real traffic crashes in Sweden. The estimated claim frequency of rear-end frontal collisions measured in claims per 1,000 insured vehicle years was 23% lower for the City Safety equipped XC60 model than for other Volvo models without the system.

  19. Real-life metabolomics data analysis: how to deal with complex data?

    NARCIS (Netherlands)

    Rubingh, C.M.

    2010-01-01

    Door de grote datasets die gegenereerd worden in metabolomics studies, in combinatie met de ingewikkelde studiedesigns die vaak nodig zijn om subtiele verschillen in metabolietprofielen te kunnen detecteren, zijn standaard multivariate technieken niet meer afdoende. Dit geldt voor alle fasen van de

  20. Epidemiology, management and outcomes of Graves' disease-real life data.

    Science.gov (United States)

    Hussain, Y S; Hookham, J C; Allahabadia, A; Balasubramanian, S P

    2017-06-01

    Treatment options in Graves' disease are clearly defined, but management practices and the perceptions of success are varied. The outcomes of treatment in large consecutive cohorts of Graves' disease have not been well characterised. The study describes the epidemiology, management strategies and medium term outcomes following anti-thyroid drug treatment, radio-iodine ablation and surgery in Graves' disease. All patients (n = 659) who received treatment for a new diagnosis of Graves' disease in secondary care over a 5 year period were included with a median (interquartile range) follow-up of 42.9 (29-57.5) months. The age adjusted incidence of adult onset Graves' disease in Sheffield, UK was 24.8 per 100,000 per year. Excluding 35 patients lost to follow-up, 93.1% (n = 581) were controlled on anti-thyroid drug treatment. Of these, 73.6% went into remission following withdrawal of anti-thyroid drugs; 5.2% were still undergoing initial therapy; 13.3% lost control whilst on anti-thyroid drugs; and 7.9% went on to have either surgery or radio-iodine ablation whilst controlled on anti-thyroid drugs. Of the 428 patients who achieved remission, 36.7% relapsed. Of 144 patients who had radio-iodine ablation treatment, 5.6% relapsed and needed further treatment. Of 119 patients having surgery, 5.2% had long-term hypoparathyroidism and none had documented long-term recurrent laryngeal nerve palsy. In the follow-up, 39.9% of patients underwent surgery or radio-iodine ablation with little morbidity. Up to two-thirds of patients who achieved remission did not relapse. Data on effectiveness and risks of treatments for Graves' disease presented in this study will help clinicians and patients in decision making.

  1. Early intervention for psychotic disorders: Real-life implementation in Hong Kong.

    Science.gov (United States)

    Wong, Gloria H Y; Hui, Christy L M; Tang, Jennifer Y M; Chang, Wing-Chung; Chan, Sherry K W; Xu, Jia-Qi; Lin, Jessie J X; Lai, Dik-Chee; Tam, Wendy; Kok, Joy; Chung, Dicky; Hung, S F; Chen, Eric Y H

    2012-03-01

    Hong Kong is among the first few cities in Asia to have implemented early intervention for psychosis in 2001. Substantial changes in psychosis service have since taken place. We reviewed available outcome data in Hong Kong, with reference to the philosophy of early intervention in psychosis, discussing experience and lessons learned from the implementation process, and future opportunities and challenges. Data accumulated in the past decade provided evidence for the benefits and significance of early intervention programmes: patients under the care of early intervention service showed improved functioning, milder symptoms, and fewer hospitalizations and suicides. Early intervention is more cost-effective compared with standard care. Stigma and misconception remains an issue, and public awareness campaigns are underway. In recent years, a critical mass is being formed, and Hong Kong has witnessed the unfolding of public service extension, new projects and organizations, and increasing interest from the community. Several major platforms are in place for coherent efforts, including the public Early Assessment Service for Young people with psychosis (EASY) programme, the Psychosis Studies and Intervention (PSI) research unit, the independent Hong Kong Early Psychosis Intervention Society (EPISO), the Jockey Club Early Psychosis (JCEP) project, and the postgraduate Psychological Medicine (Psychosis Studies) programme. The first decade of early intervention work has been promising; consolidation and further development is needed on many fronts of research, service and education. Copyright © 2012 Elsevier B.V. All rights reserved.

  2. Real-life treatment of metastatic colorectal cancer with regorafenib: a single-centre review.

    Science.gov (United States)

    Gotfrit, J; Vickers, M; Sud, S; Asmis, T; Cripps, C; Goel, R; Hsu, T; Jonker, D; Goodwin, R

    2017-08-01

    Various tyrosine kinase signalling pathways affect the development and progression of colorectal cancer (crc). In clinical trials, regorafenib has been associated with a survival benefit in metastatic crc (mcrc). We assessed the safety and efficacy of regorafenib in real-world patients. In a retrospective review of patients with mcrc treated with regorafenib at our institution from 2013 to 2015, patient demographics, treatment, and survival data were collected. Progression-free survival (pfs) and overall survival (os) were estimated using the Kaplan-Meier method. In total, 48 patients were offered regorafenib, and 35 (73%) started treatment. Of the patients who started regorafenib, 57% were men. Median age in the cohort was 61 years, and all patients had a performance status in the range 0-2. Time from diagnosis of mcrc to regorafenib treatment was more than 18 months in 71% of patients. Starting dose was 160 mg in 54% of the patients, 120 mg in 40%, and 80 mg in 6%. Dose reductions occurred in 34% of the patients, and interruptions, in 29%. Best response was progressive disease (60%) and stable disease (17%); response in the rest of the patients was unknown. The most common adverse events on regorafenib (any grade) were fatigue (57%), hyperbilirubinemia (43%), thrombocytopenia (37%), anorexia (31%), and hypertension (31%). The most common grade 3 or 4 adverse events were fatigue (29%), hypophosphatemia (17%), weight loss (11%), and hyperbilirubinemia (9%). Common reasons for discontinuing regorafenib included progressive disease (51%) and toxicity (26%). In patients treated with regorafenib, pfs was 2.4 months (95% confidence interval: 1.8 to 3.3 months) and os was 5.6 months (95% confidence interval: 3.7 to 8.9 months). No factors were associated with survival in univariate or multivariate analysis. In a real-world setting, regorafenib is associated with survival similar to that reported in the randomized controlled trials, but at the expense of toxicity leading to discontinuation in many patients. Future studies of regorafenib should focus on identifying the patients most likely to benefit and on minimizing toxicity.

  3. Implementation Process of 5S for a Company in Real Life - Problems, Solutions, Successes

    Science.gov (United States)

    Czifra, György

    2017-09-01

    Developed in Japan, 5S is a system of organizing workplace for efficiency, effectiveness and safety. Is 5s important? The answer is: "YES", because the implementation is about empowering employees to control their work area and create an environment where they want to work every day. It is a program that only works with grass roots level engagement. With commitment to safety, we are equally committed to 5S to ensure a safe place to work. It enabled us to indicate where waste was occurring and thus improve the work area sustainably. We recognized real problems, found solutions and ultimately we were successful in our endeavors. Throughout different companies, various words of similar meaning are used. No matter what specific words are used to identify the steps in 5S, the purpose remains the same: create a clean, organized and efficient work environment.

  4. Identifying hazardous alcohol consumption during pregnancy: implementing a research-based model in real life.

    Science.gov (United States)

    Göransson, Mona; Magnusson, Asa; Heilig, Markus

    2006-01-01

    It has been repeatedly demonstrated that hazardous alcohol use during pregnancy is rarely detected in regular antenatal care, and that detection can be markedly improved using systematic screening. A major challenge is to translate research-based strategies into regular antenatal care. Here, we examined whether a screening strategy using the Alcohol Use Disorder Test (AUDIT) and time-line follow-back (TLFB) could be implemented under naturalistic conditions and within available resources; and whether it would improve detection to the extent previously shown in a research context. Regular midwives at a large antenatal care clinic were randomized to receive brief training and then implement AUDIT and TLFB ("intervention"); or to a waiting-list control group continuing to deliver regular care ("control"). In the intervention-condition, AUDIT was used to collect data about alcohol use during the year preceding pregnancy, and TLFB to assess actual consumption during the first trimester. Data were collected from new admissions over 6 months. Drop out was higher among patients of the intervention group than control midwives, 14% (23/162) versus 0% (0/153), and ppregnancy i.e. AUDIT score 6 or higher (17%, 23/139), and patients with ongoing consumption exceeding 70 g/week and/or binge consumption according to TLFB (17%, 24/139), to a significantly higher degree than regular antenatal screening (0/162). The AUDIT- and TLFB-positive populations overlapped partially, with 36/139 subjects screening positive with either of the instrument and 11/139 were positive for both. We confirm previous findings that alcohol use during pregnancy is more extensive in Sweden than has generally been realized. Systematic screening using AUDIT and TLFB detects hazardous use in a manner which regular antenatal care does not. This remains true under naturalistic conditions, following minimal training of regular antenatal care staff, and can be achieved with minimal resources. The proposed strategy appears attractive for broad implementation.

  5. Clinical characteristics and real-life diagnostic approaches in all Danish children with hereditary angioedema

    DEFF Research Database (Denmark)

    Aabom, Anne; Andersen, Klaus E; Fagerberg, Christina

    2017-01-01

    at onset was 4 [1-11] years. The first attack was peripheral in 8/14 children and abdominal in 6/14 children, i.e. no one had their first attacks in the upper airways. Most children had less than one attack per month. All of the symptomatic children had been treated with tranexamic acid and/or C1 inhibitor...

  6. Career and Technology Center Guides Students in Real-Life Careers | Poster

    Science.gov (United States)

    By Carolynne Keenan, Contributing Writer Frederick County Public School students have a unique opportunity—a chance to get a real-world, hands-on experience in biomedical science and biotechnology before they even graduate from high school, thanks to the Frederick County Career and Technology Center (CTC). Several years ago, the CTC established its biomedical sciences program

  7. Mapping dynamic social networks in real life using participants' own smartphones

    NARCIS (Netherlands)

    Boonstra, T.W.; Larsen, M.E.; Christensen, H.

    2015-01-01

    Interpersonal relationships are vital for our daily functioning and wellbeing. Social networks may form the primary means by which environmental influences determine individual traits. Several studies have shown the influence of social networks on decision-making, behaviors and wellbeing.

  8. Causal attributions, real life-events and personality characteristics : a preliminary study

    NARCIS (Netherlands)

    SANDERMAN, R

    1986-01-01

    The learned-helplessness model has been given much attention recently. In this article some issues are briefly reviewed, the main purpose of this study was, however, to determine the relationship between causal attributions and personality characteristics, symptoms and feelings of well-being.

  9. Family, Friends, and Self: The Real-Life Context of an Abnormal Psychology Class.

    Science.gov (United States)

    Connor-Greene, Patricia A.

    2001-01-01

    Presents results from a survey of students in two sections of an abnormal psychology course. Assessed the number of students who had firsthand exposure to a psychiatric disorder (friend, family member, or themselves), the nature of the relationship, the average number of personal relationships with people with psychiatric disorders, and the…

  10. Virtual Voices with Real-Life Consequences: Teaching Students about Cyber-Vetting

    Science.gov (United States)

    Hanasono, Lisa Kiyomi

    2013-01-01

    Despite its pervasiveness, many students do not realize how online communication can impact their careers and relationships. Cyber-vetting occurs when people use online search engines, social networking sites, and other Internet tools to uncover information about others. Because cyber-vetting is a relatively new concept, most communication…

  11. Reconstruction of 3d video from 2d real-life sequences

    Directory of Open Access Journals (Sweden)

    Eduardo Ramos Diaz

    2010-01-01

    Full Text Available En este artículo, se propone un método novedoso que permite generar secuencias de video en 3D usando secuencias de video reales en 2D. La reconstrucción de la secuencia de video en 3D se realiza usando el cálculo del mapa de profundidad y la síntesis de anaglifos. El mapa de profundidad es formado usando la técnica de correspondencia estéreo basada en la minimización de la energía de error global a partir de funciones de suavizado. La construcción del anaglifo es realizada usando la alineación del componente de color interpolándolo con el mapa de profundidad previamente formado. Adicionalmente, se emplea la transformación del mapa de profundidad para reducir el rango dinámico de los valores de disparidad, minimizando el efecto fantasma mejorando la preservación de color. Se usaron numerosas secuencias de video a color reales que contienen diferentes tipos de movimientos como traslacional, rotacional, acercamiento, y la combinación de los anteriores, demostrando buen funcionamiento visual de la reconstrucción de secuencias de video en 3D propuesta.

  12. A Reliance on Recollection for Emotional Real-life Scenes: Evidence from Source Retrieval Task

    OpenAIRE

    Bennett, Emily E

    2011-01-01

    The diverse effects of emotion on human memory is a topic of discussion that has brought about much interest within psychology (Cardwell, Clark and Meldrum, 2004) with a particular emphasis on how further understanding of its influence can aid our knowledge about the structure of underlying memory systems. In recognition memory research, dual-process models propose that judgements can be based on two independent retrieval processes: “familiarity”, based on the perception of a memory’s strengt...

  13. Air-to-air heat pumps in real-life use

    DEFF Research Database (Denmark)

    Gram-Hanssen, Kirsten; Christensen, Toke Haunstrup; Petersen, Poul Erik

    2012-01-01

    This paper deals with individual air-to-air heat pumps in Danish dwellings and summerhouses and the question of to what extent they actually deliver savings of energy consumption. Results show that 20% of the expected reduction of electricity consumption is converted into increased comfort...... in the homes, including extended heating areas, keeping a higher temperature and a longer heating season and using the heat pump for air conditioning. Data include electricity consumption in 185 households before and after installation of heat pumps together with survey results of 480 households. Furthermore...... heating practices. These results have to be taken into account when making long-term energy planning for a sustainable energy system....

  14. The effect of video game violence on psychological desensitization to real life violence

    NARCIS (Netherlands)

    Carnagey, N.L.; Anderson, C.A.; Bushman, B.J.

    2007-01-01

    Past research shows that violent video game exposure increases aggressive thoughts, angry feelings, physiological arousal, aggressive behaviors, and decreases helpful behaviors. However, no research has experimentally examined violent video game effects on physiological desensitization, defined as

  15. Use of oral antineoplastic in special situations in a third level hospital: real life results.

    Science.gov (United States)

    Garcia-Muñoz, Carmen; Rodriguez-Quesada, Pedro Pablo; Ferrari-Piquero, José Miguel

    2018-01-01

    To analyse the effectiveness and safety of oral antineoplastic drugs  (ANEOs) that are authorized in special situations in a third-level hospital and to  compare the results obtained with the clinical evidence used for this  authorization. Descriptive observational and retrospective study. We included all  adult patients who started treatment with ANEO in special situations during the  year 2016. We collected demographic, treatment-related and clinical variables  (overall survival (OS), progression-free survival (PFS)). Adverse reactions and  detected interactions were collected. An unadjusted comparison was made  between the results of the available evidence and those of the study patients. 34 patients were treated, 50% were men, the median age was 58  years (38-80) and they presented ECOG 1 in 64.7%. Most of the treated  patients were diagnosed with advanced colorectal cancer, treated with  trifluridine-tipiracil, followed by palbociclib in breast cancer, obtaining results  similar to those of the evidence. The median PFS was 2.8 months (95% CI 0.8- 4.8) and the 8-month SG (95% CI 3.4-12.5) for all patients. 26% of patients  required dose reduction because of treatment toxicity. We found 13 interactions,  which affected 15 patients, only two of category X. The effectiveness of ANEO in special situations in our center is  similar to that of available evidence. The impact on survival is low and adverse  effects are common. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  16. Modelling of domestic refrigerators' energy consumption under real life conditions in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Geppert, Jasmin

    2011-05-23

    In recent decades, energy and resource savings have become increasingly important, not only in the industrial, but also the residential sector. As one of the largest energy users in private homes, domestic refrigerators and freezers were among the first appliances to be targeted for energy efficiency improvements. With the aim of encouraging manufacturers to develop and produce more efficient appliances, the European Energy Label was introduced in the mid-nineties. However, the energy use of refrigerators does not only depend on technical components and features. Especially the using conditions in private homes are of a decisive influence. Thus, the present study has been conducted to test the sensitivity of refrigerators' energy consumption to various usage conditions within realistic ranges, which have been determined by means of two empirical studies. Key information gathered from the experiments were used as a base for the development and validation of a simplified model that allows predicting the energy consumption of refrigerators in use. The practical experiments were performed under controlled laboratory conditions with four different refrigerators with an A{sup +} or A{sup ++} energy efficiency rating (two statically cooled built-in fridge-freezers, one dynamically cooled refrigerator and one statically cooled refrigerator). The investigations revealed that the ambient temperature has the greatest impact on a refrigerator's energy consumption, followed by thermostat setting and heat load by insertion of warm items. The refrigerators' load under static conditions as well as the number of door openings have almost no impact on energy consumption. The modelling methodology follows a first-principle approach adjusted by experimental data. When compared to experimental results, model predictions show a reasonable agreement for the whole range of investigated conditions. (orig.)

  17. Real-life characteristics of asthma inhaler device use in South Korea

    NARCIS (Netherlands)

    Wan Yau Ming, S.; Rhee, C.K.; Park, H.Y.; Yoo, K.H.; Kim, D.K.; Van Boven, J.F.; Price, D.; Park, H.S.

    2016-01-01

    Background and Aims: Historically, dry powder inhalers (DPIs) were considered to provide better airway distribution, easier identification of empty devices, and easier handling when compared to pressurized metered dose inhalers (pMDIs). Prior research into the major handling errors with inhaler

  18. How Well Does the ICHD 3 (Beta) Help in Real-Life Migraine Diagnosis and Management?

    DEFF Research Database (Denmark)

    Ashina, Sait; Olesen, Jes; Lipton, Richard B

    2016-01-01

    Classification has played a major role in the diagnosis of primary headache conditions including migraine with and without aura. With many updates and changes, the International Classification of Headache Disorders (ICHD)-3 beta is currently considered as the gold standard for classification...

  19. Real-life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria.

    Science.gov (United States)

    Hew, M; Gillman, A; Sutherland, M; Wark, P; Bowden, J; Guo, M; Reddel, H K; Jenkins, C; Marks, G B; Thien, F; Rimmer, J; Katsoulotos, G P; Cook, M; Yang, I; Katelaris, C; Bowler, S; Langton, D; Wright, C; Bint, M; Yozghatlian, V; Burgess, S; Sivakumaran, P; Yan, K Y; Kritikos, V; Peters, M; Baraket, M; Aminazad, A; Robinson, P; Jaffe, A; Powell, H; Upham, J W; McDonald, V M; Gibson, P G

    2016-11-01

    Omalizumab (Xolair) dosing in severe allergic asthma is based on serum IgE and bodyweight. In Australia, patients eligible for omalizumab but exceeding recommended ranges for IgE (30-1500 IU/mL) and bodyweight (30-150 kg) may still receive a ceiling dose of 750 mg/4 weeks. About 62% of patients receiving government-subsidized omalizumab are enrolled in the Australian Xolair Registry (AXR). To determine whether AXR participants above the recommended dosing ranges benefit from omalizumab and to compare their response to within-range participants. Data were stratified according to dose range status (above-range or within-range). Further sub-analyses were conducted according to the reason for being above the dosing range (IgE only vs. IgE and weight). Data for 179 participants were analysed. About 55 (31%) were above recommended dosing criteria; other characteristics were similar to within-range participants. Above-range participants had higher baseline IgE [812 (IQR 632, 1747) IU/mL vs. 209 (IQR 134, 306) IU/mL] and received higher doses of omalizumab [750 (IQR 650, 750) mg] compared to within-range participants [450 (IQR, 300, 600) mg]. At 6 months, improvements in Juniper 5-item Asthma Control Questionnaire (ACQ-5, 3.61 down to 2.01 for above-range, 3.47 down to 1.93 for within-range, P omalizumab have significantly improved symptom control, quality of life and lung function to a similar degree to within-range participants, achieved without dose escalation above 750 mg. © 2016 John Wiley & Sons Ltd.

  20. Omalizumab treats chronic rhinosinusitis with nasal polyps and asthma together-a real life study.

    Science.gov (United States)

    Bidder, T; Sahota, J; Rennie, C; Lund, V J; Robinson, D S; Kariyawasam, H H

    2018-03-01

    Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma often coexist and thus treating both with one intervention is an attractive strategy. To prospectively evaluate whether treatment with the monoclonal antibody against IgE Omalizumab for severe allergic asthma also effectively treats co-existent CRSwNP. SNOT-22 and the ACQ-7 scores were recorded at 4 and 16 weeks of treatment in a cohort of patients with both CRSwNP and severe refractory allergic asthma treated with Omalizumab (n=13) according to UK guidelines for their severe asthma. SNOT-22 in a surgery only treated CRSwNP with asthma group (n=24) was compared. Rapid improvement was seen at 4 weeks and 16 weeks of treatment in both CRSwNP and asthma control. The improvement in CRSwNP with Omalizumab was similar to that seen in a group of patients who received upper airway surgery. Omalizumab treatment for severe allergic asthma also improves co-existent CRSwNP. Further clinical studies of current and emerging biological agents for severe asthma should include upper airway outcomes. These agents may be effective for severe CRSwNP and comparative studies with surgery are warranted.