Sample records for reaction channels leading

  1. The $\\bar{K} N \\rightarrow K \\Xi$ reaction in coupled channel chiral models up to next-to-leading order

    Feijoo, A; Ramos, A


    The meson-baryon interaction in s-wave in the strangeness S=-1 sector has been studied, employing a chiral SU(3) Lagrangian up to next-to-leading order (NLO) and implementing unitarization in coupled channels. The parameters of the Lagrangian have been fitted to a large set of experimental data in different two-body channels, paying special attention to the $\\bar{K} N \\rightarrow K \\Xi$ reaction, which is particularly sensitive to the NLO terms. With the aim of improving the model in the $K\\Xi$ production channels, effects of the high spin hyperon resonances $\\Sigma(2030)$ and $\\Sigma(2250)$ have been taken into account phenomenologically.

  2. Entrance channel effects on the evaporation residue yields in reactions leading to the $^{220}$Th compound nucleus

    Kim, Kyungil; Mandaglio, Giuseppe; Giardina, Giorgio; Kim, Youngman


    The evaporation residue yields from compound nuclei $^{220}$Th formed in the $^{16}$O+$^{204}$Pb, $^{40}$Ar+$^{180}$Hf, $^{82}$Se+$^{138}$Ba, $^{124}$Sn+$^{96}$Zr reactions are analyzed to study the entrance channel effects by comparison of the capture, fusion and evaporation residue cross sections calculated by the combined dinuclear system (DNS) and advanced statistical models. The difference between evaporation residue (ER) cross sections can be related to the stages of compound nucleus formation or/and at its surviving against fission. The sensitivity of the both stages in the evolution of DNS up to the evaporation residue formation to the angular momentum of DNS is studied. The difference between fusion excitation functions are explained by the hindrance to complete fusion due to the larger intrinsic fusion barrier $B^*_{\\rm fus}$ for the transformation of the DNS into a compound nucleus and the increase of the quasifission contribution due to the decreasing of quasifission barrier $B_{\\rm qf}$ as a func...

  3. Efficient path sampling on multiple reaction channels

    van Erp, Titus S.


    Due to the time scale problem, rare events are not accessible by straight forward molecular dynamics. The presence of multiple reaction channels complicates the problem even further. The feasibility of the standard free energy based methods relies strongly on the success in finding a proper reaction coordinate. This can be very difficult task in high-dimensional complex systems and even more if several distinct reaction channels exist. Moreover, even if a proper reaction coordinate can be fou...

  4. Radiation Reaction in a Continuous Focusing Channel

    Huang, Zhirong; Chen, Pisin; Ruth, Ronald D.


    We show that the radiation damping rate of the transverse action of a particle in a straight, continuous focusing system is independent of the particle energy, and that no quantum excitation is induced. This absolute damping effect leads to the existence of a transverse ground state to which the particle inevitably decays and yields the minimum beam emittance that one can ever attain, γɛmin = /2mc, limited only by the uncertainty principle. Because of adiabatic invariance, the particle can be accelerated along the focusing channel in its ground state without any radiation energy loss.

  5. Substrate dependent reaction channels of the Wolff–Kishner reduction reaction: A theoretical study

    Shinichi Yamabe


    Full Text Available Wolff–Kishner reduction reactions were investigated by DFT calculations for the first time. B3LYP/6-311+G(d,p SCRF=(PCM, solvent = 1,2-ethanediol optimizations were carried out. To investigate the role of the base catalyst, the base-free reaction was examined by the use of acetone, hydrazine (H2N–NH2 and (H2O8. A ready reaction channel of acetone → acetone hydrazine (Me2C=N–NH2 was obtained. The channel involves two likely proton-transfer routes. However, it was found that the base-free reaction was unlikely at the N2 extrusion step from the isopropyl diimine intermediate (Me2C(H–N=N–H. Two base-catalyzed reactions were investigated by models of the ketone, H2N–NH2 and OH−(H2O7. Here, ketones are acetone and acetophenone. While routes of the ketone → hydrazone → diimine are similar, those from the diimines are different. From the isopropyl diimine, the N2 extrusion and the C–H bond formation takes place concomitantly. The concomitance leads to the propane product concertedly. From the (1-phenylethyl substituted diimine, a carbanion intermediate is formed. The para carbon of the phenyl ring of the anion is subject to the protonation, which leads to a 3-ethylidene-1,4-cyclohexadiene intermediate. Its [1,5]-hydrogen migration gives the ethylbenzene product. For both ketone substrates, the diimines undergoing E2 reactions were found to be key intermediates.

  6. Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms

    Qiong-Yao Tang


    Full Text Available Twelve sodium-activated potassium channel (KCNT1, Slack genetic mutants have been identified from severe early-onset epilepsy patients. The changes in biophysical properties of these mutants and the underlying mechanisms causing disease remain elusive. Here, we report that seven of the 12 mutations increase, whereas one mutation decreases, the channel’s sodium sensitivity. Two of the mutants exhibit channel over-activity only when the intracellular Na+ ([Na+]i concentration is ∼80 mM. In contrast, single-channel data reveal that all 12 mutants increase the maximal open probability (Po. We conclude that these mutant channels lead to channel over-activity predominantly by increasing the ability of sodium binding to activate the channel, which is indicated by its maximal Po. The sodium sensitivity of these epilepsy causing mutants probably determines the [Na+]i concentration at which these mutants exert their pathological effects.

  7. Morphology of melt-rich channels formed during reaction infiltration experiments on partially molten mantle rocks

    Pec, Matej; Holtzman, Benjamin; Zimmerman, Mark; Kohlstedt, David


    Geochemical, geophysical and geological observations suggest that melt extraction from the partially molten mantle occurs by some sort of channelized flow. Melt-solid reactions can lead to melt channelization due to a positive feedback between melt flow and reaction. If a melt-solid reaction increases local permeability, subsequent flow is increased as well and promotes further reaction. This process can lead to the development of high-permeability channels which emerge from background flow. In nature, anastomozing tabular dunite bodies within peridotitic massifs are thought to represent fossilized channels that formed by reactive flow. The conditions under which such channels can emerge are treated by the reaction infiltration instability (RII) theory (e.g. Szymczak and Ladd 2014). In this contribution, we report the results of a series of Darcy type experiments designed to study the development of channels due to RII in mantle lithologies (Pec et al. 2015). We sandwiched a partially molten rock between a melt source and a porous sink and annealed it at high-pressures (P = 300 MPa) and high-temperatures (T = 1200° or 1250° C) under a controlled pressure gradient (∇P = 0-100 MPa/mm) for up to 5 hours. The partially molten rock is formed by 50:50 mixtures of San Carlos olivine (Ol, Fo ˜ 88) and clinopyroxene (Cpx) with either 4, 10 or 20 vol% of alkali basalt added. The source and sink are disks of alkali basalt and porous alumina, respectively. During the experiments, silica undersaturated melt from the melt source dissolves Cpx and precipitates an iron rich Ol (Fo ˜ 82) thereby forming a Cpx-free reaction layer at the melt source - partially molten rock interface. The melt fraction in the reaction layer increases significantly (40% melt) compared to the protolith, confirming that the reaction increases the permeability of the partially molten rock. In experiments annealed under a low pressure gradient (and hence slow melt flow velocity) the reaction layer is

  8. Entrance channel effect in the incomplete fusion reactions

    Singh B.P.


    Full Text Available In the present work the effect of various entrance channel parameters on incomplete fusion strength and the reaction dynamics in 12C+159Tb system at energies ≈ 4-7MeV/A have been investigated by measuring the excitation functions of individual reaction channels. Experimental excitation functions have been analyzed in the framework of compound nucleus decay using statistical model code PACE4. Analysis of data suggests the production of xn/pxn-channels via complete fusion of 12C with 159Tb, as these are found to be well reproduced by PACE4 predictions, while, a significant enhancement in the excitation functions of α-emitting channels has been observed over the theoretical ones. This enhancement has been attributed due to incomplete fusion. For better insight into the underlying dynamics, fraction of incomplete fusion to the total fusion has been deduced and compared with 16O+159Tb and other nearby systems as a function of various entrance channel parameters. The fraction of incomplete fusion has been found to be sensitive to the projectile type, energy and entrance-channel mass-asymmetry.

  9. Comparative dynamics of the two channels of the reaction of D + MuH.

    Aoiz, F J; Aldegunde, J; Herrero, V J; Sáez-Rábanos, V


    The dynamics of the asymmetric D + MuH (Mu = Muonium) reaction leading to Mu exchange, DMu + H, and H abstraction, DH + Mu, channels has been investigated using time-independent quantum mechanical (QM) calculations. Reaction probabilities, cross sections, cumulative reaction probabilities, and rate coefficients were determined for the two exit channels of the reaction. Quasiclassical trajectory (QCT) calculations were also performed in order to check the reliability of the method for this reaction and to discern the genuine quantum effects. Overall, the Mu exchange channel exhibits more structured reaction probabilities and cross sections with much larger rate coefficients than the H abstraction counterpart. Over the 100-1000 K temperature interval considered in this study, the QM rate coefficients for the Mu exchange vary between ≈5 × 10(-15) and 2 × 10(-11) cm(3) s(-1) and those for the generation of DH + Mu between 2 × 10(-18) and 3.5 × 10(-12) cm(3) s(-1). In common with the rest of the isotopologues of the H + H2 system, the height of the respective barriers in the collinear (symmetric stretch) vibrationally adiabatic potential energy curves matches the classical total energy threshold very accurately. Indeed, the lower and narrower vibrationally adiabatic collinear barrier as compared with that for the DH + Mu formation determines the preponderance of the DMu + H channel. Comparison of QM and QCT results and their analysis show that tunneling accounts for the reactivity at energies below the height of these barriers and that its effect on the rate coefficients becomes appreciable below 300 K. As expected, with growing temperature the contribution of tunneling to the global reactivity decreases markedly, but the rate coefficients are still much higher for the Mu exchange channel due to the effect of MuH rotational excitation that boosts the formation of DMu while diminishing the H abstraction channel that leads to DH formation. The analysis of the

  10. Reaction Mechanism of the Multi-channel Decomposition Reactions of 1-Pentenyl Free Radicals

    CHENG,Xue-Li; ZHAO,Yan-Yun; LI,Feng; LI,Li-Qing; TAO,Xiu-Jun


    The reactions of 1-pentenyl decomposition system have been studied extensively at the B3LYP/6-311++G** level with Gaussion 98 package. The potential energy surface with zero-point energy correction was drawn. All reaction channels were fully investigated with the vibrational mode analysis, frontier orbital analysis and electron population analysis to confirm the transition states and reveal the reaction mechanism.

  11. Multi-reaction-channel fitting calculations in a coupled-channel model: Photoinduced strangeness production

    O Scholten; A Usov


    To describe photo- and meson-induced reactions on the nucleon, one is faced with a rather extensive coupled-channel problem. Ignoring the effects of channel coupling, as one would do in describing a certain reaction at the tree level, invariably creates a large inconsistency between the different reactions that are described. In addition, the imaginary parts of the amplitude, which are related through the optical theorem, to total cross-sections, are directly reflected in certain polarization observables. Performing a full coupled-channel calculation thus offers the possibility to implement the maximum number of constraints. The drawback one is faced with is to arrive at a simultaneous fit of a large number of reaction channels. While some of the parameters are common to many reactions, one is still faced with the challenge to optimize a large number of parameters in a highly non-linear calculation. Here we show that such an approach is possible and present some results for photoinduced strangeness production.

  12. Thermal behavior in the cracking reaction zone of scramjet cooling channels at different channel aspect ratios

    Zhang, Silong; Feng, Yu; Jiang, Yuguang; Qin, Jiang; Bao, Wen; Han, Jiecai; Haidn, Oskar J.


    To study the thermal behavior in the cracking reaction zone of regeneratively cooled scramjet cooling channels at different aspect ratios, 3-D model of fuel flow in terms of the fuel's real properties and cracking reaction is built and validated through experiments. The whole cooling channel is divided into non-cracking and cracking reaction zones. Only the cracking reaction zone is studied in this article. The simulation results indicate that the fuel conversion presents a similar distribution with temperature because the fuel conversion in scramjet cooling channels is co-decided by the temperature and velocity but the temperature plays the dominate role. For the cases given in this paper, increasing the channel aspect ratio will increase the pressure drop and it is not beneficial for reducing the wall temperature because of the much severer thermal stratification, larger conversion non-uniformity, the corresponding M-shape velocity profile which will cause local heat transfer deterioration and the decreased chemical heat absorption. And the decreased chemical heat absorption caused by stronger temperature and conversion non-uniformities is bad for the utilization of chemical heat sink, chemical recuperation process and the ignition performance.

  13. Large fraction of crystal directions leads to ion channeling

    Nordlund, K.; Djurabekova, F.; Hobler, G.


    It is well established that when energetic ions are moving in crystals, they may penetrate much deeper if they happen to be directed in some specific crystal directions. This `channeling' effect is utilized for instance in certain ion beam analysis methods and has been described by analytical theories and atomistic computer simulations. However, there have been very few systematic studies of channeling in directions other than the principal low-index ones. We present here a molecular dynamics-based approach to calculate ion channeling systematically over all crystal directions, providing ion `channeling maps' that easily show in which directions channeling is expected. The results show that channeling effects can be quite significant even at energies below 1 keV, and that in many cases, significant planar channeling occurs also in a wide range of crystal directions between the low-index principal ones. In all of the cases studied, a large fraction (˜20 -60 % ) of all crystal directions show channeling. A practical implication of this is that modern experiments on randomly oriented nanostructures will have a large probability of channeling. It also means that when ion irradiations are carried out on polycrystalline samples, channeling effects on the results cannot a priori be assumed to be negligible. The maps allow for easy selection of good `nonchanneling' directions in experiments or alternatively finding wide channels for beneficial uses of channeling. We implement channeling theory to also give the fraction of channeling directions in a manner directly comparable to the simulations. The comparison shows good qualitative agreement. In particular, channeling theory is very good at predicting which channels are active at a given energy. This is true down to sub-keV energies, provided the penetration depth is not too small.

  14. A model study of sequential enzyme reactions and electrostatic channeling.

    Eun, Changsun; Kekenes-Huskey, Peter M; Metzger, Vincent T; McCammon, J Andrew


    We study models of two sequential enzyme-catalyzed reactions as a basic functional building block for coupled biochemical networks. We investigate the influence of enzyme distributions and long-range molecular interactions on reaction kinetics, which have been exploited in biological systems to maximize metabolic efficiency and signaling effects. Specifically, we examine how the maximal rate of product generation in a series of sequential reactions is dependent on the enzyme distribution and the electrostatic composition of its participant enzymes and substrates. We find that close proximity between enzymes does not guarantee optimal reaction rates, as the benefit of decreasing enzyme separation is countered by the volume excluded by adjacent enzymes. We further quantify the extent to which the electrostatic potential increases the efficiency of transferring substrate between enzymes, which supports the existence of electrostatic channeling in nature. Here, a major finding is that the role of attractive electrostatic interactions in confining intermediate substrates in the vicinity of the enzymes can contribute more to net reactive throughput than the directional properties of the electrostatic fields. These findings shed light on the interplay of long-range interactions and enzyme distributions in coupled enzyme-catalyzed reactions, and their influence on signaling in biological systems.

  15. A subcutaneous channeling probe for implanting long leads

    Lund, G. F.; Simmonds, R. C.; Williams, B. A.


    The channeling probe described in the present paper was designed to overcome surgical problems of the type that were encountered when a multichannel radio transmitter had to be implanted in a cow. The probe was made of a flexible but sufficiently stiff 9.5-mm-diam nylon rod, consisting of 46-cm sections for convenience in sterilization and surgical handling. Stainless steel sleaves reinforced the threaded connecting joints. At one end, arrowhead-shaped channeling heads could be attached to produce wide channels for large sensors. The other end was tapered for narrow channels. Postoperative problems were not encountered in the use of this probe in cows, sheep, and dogs.

  16. Study of all Reaction Channels in Deuteron-Deuteron Scattering

    Ramazani-Moghaddam-Arani, A.; Amir-Ahmadi, H. R.; Bacher, A. D.; Bailey, C. D.; Biegun, A.; Eslami-Kalantari, M.; Gašparić, I.; Joulaeizadeh, L.; Kalantar-Nayestanaki, N.; Kistryn, St.; Kozela, A.; Mardanpour, H.; Messchendorp, J. G.; Micherdzinska, A. M.; Moeini, H.; Shende, S. V.; Stephan, E.; Stephenson, E. J.; Sworst, R.

    Few-nucleon systems can be used as fundamental laboratories for studying details of the nuclear force effects. We performed a series of deuteron-deuteron scattering experiments at intermediate energies. The experiments exploited BINA and BBS experimental setups and polarized deuteron beams with kinetic energies of 65 and 90 MeV/nucleon. These experiments aim to measure differential cross sections, vector and tensor analyzing powers of all available reaction channels in deuteron-deuteron scattering. With these data we will provide a systematic database, which will be used to test present theoretical approximations and upcoming ab-initio calculations in four-nucleon system.

  17. Two Lower-barrier Channels in the Reaction of HF with HOBO


    Two possible lower barrier reaction pathways in the reaction HF+HOBO → H2O+FBO are predicated by means of MP2 and CCSD(T) (single-point) methods. In the two channels, two stable intermediates are loeated and thus,they are multi-step channels,which are more favorable in energy than direct single-step reaction pathway predicated by previous theoretical study. Therefore,the two pathways should be main reaction channels in experiments.

  18. Could a defective epithelial sodium channel lead to bronchiectasis

    Hubert Dominique


    Full Text Available Abstract Background Bronchiectasis is defined as a permanent dilation of the airways arising from chronic bronchial inflammation/infection. In 50% of cases, no etiology can be identified. Recently, the role of the epithelial sodium channel ENaC has been pointed out in the pathophysiology of cystic fibrosis, a disease due to mutations in the CFTR gene and causing bronchiectasis in the airways. Moreover, it was found that transgenic mice overexpressing ENaCβ present cystic fibrosis-like lung disease symptoms. Our aim was to evaluate if a defective ENaC protein could be involved in the development of bronchiectasis. Methods We extensively analysed ENaCβ and γ genes in 55 patients with idiopathic bronchiectasis and without two mutations in the coding regions of CFTR. Thirty-eight patients presented functional abnormalities suggesting impaired sodium transport (abnormal sweat chloride concentration or nasal potential difference measurement, and 17 had no such evidence. Results Sequencing of the exons and flanking introns of the ENaCβ and γ gene identified five different amino-acid changes (p.Ser82Cys, p.Pro369Thr, p.Asn288Ser in ENaCβ ; and p.Gly183Ser, p.Glu197Lys in ENaCγ in heterozygous state in 8 patients. The p.Ser82Cys amino-acid change was found in 3 unrelated patients who were also heterozygous for a CFTR mutation or variant (1 p.F508del, 1 IVS8-5T, and 1 IVS8-5T:1716G>A (p.E528E. The other mutations were found in patients without CFTR mutation, the p.Glu197Lys mutation in 2 patients and the other variants in single patients. Among the 8 patients bearing an ENaC mutation, 5 had functional abnormalities suggesting impaired sodium transport. Conclusion Our results suggest that several variants in ENaCβ and γ genes might be deleterious for ENaC function and lead to bronchiectasis, especially in patients who are trans-heterozygotes for ENaCβ/CFTR mutations or variants.

  19. The effects of inorganic lead on voltage-sensitive calcium channels differ among cell types and among channel subtypes.

    Audesirk, G; Audesirk, T


    The whole-cell version of patch clamping was used to compare the effects of acute in vitro exposure to inorganic lead (Pb2+) on voltage-sensitive calcium channels in cultured N1E-115 mouse neuroblastoma cells and E18 rat hippocampal neurons. Free Pb2+ concentrations in salines with a high lead-buffering capacity were measured with a calibrated Pb(2+)-selective electrode. Previously, we found that N1E-115 neurons contain low voltage activated, rapidly inactivating (T) channels and high voltage activated, slowly inactivating (L) channels. Pb2+ inhibits both channel subtypes in N1E-115 cells, with some selectivity against L-type channels (IC50 approximately 700 nM free Pb2+ for L-type channels, 1300 nM free Pb2+ for T-type channels; Audesirk and Audesirk, 1991). In addition to T-type and L-type channels, cultured E18 rat hippocampal neurons have been reported to contain high voltage-activated, rapidly inactivating (N) channels. In our experiments with 5 to 20 day old cultures, almost all neurons showed substantial L-type current, approximately half showed significant N-type current, and fewer than 5% showed significant T-type current. We found that Pb2+ is somewhat selective against L-type channels (IC50 approximately 30 nM free Pb2+ in 10 mM Ba2+ as the charge carrier, 55 nM in 50 mM Ba2+) compared to N-channels (IC50 approximately 80 nM free Pb2+ in 10 mM Ba2+, 200 nM in 50 mM Ba2+). These results suggest that the effects of Pb2+ on calcium channels of vertebrate neurons vary both among cell types and among channel subtypes.

  20. Statistical Hauser-Feshbach theory with width fluctuation correction including direct reaction channels for neutron induced reaction at low energies

    Kawano, T; Hilaire, S


    A model to calculate particle-induced reaction cross sections with statistical Hauser-Feshbach theory including direct reactions is given. The energy average of scattering matrix from the coupled-channels optical model is diagonalized by the transformation proposed by Engelbrecht and Weidenm\\"{u}ller. The ensemble average of $S$-matrix elements in the diagonalized channel space is approximated by a model of Moldauer [Phys.Rev.C {\\bf 12}, 744 (1975)] using newly parametrized channel degree-of-freedom $\

  1. Role of ions and ion channels in capacitation and acrosome reaction of spermatozoa

    SharadBPurohit; MaliniLaloraya; G.pradeepkumar


    Capacitation and acrosome reaction are important prerequisites of the fertilization process. Capacitation is a highlycomplex phenomenon occurring in the female genital tract, rendering the spermatozoa capable of binding and fusionwith the oocyte. During capacitation various biochemical and biophysical changes occur in the spermatozoa and thespermatozoal membranes. Ions and ion channels also play important roles in governing the process of capacitation bychanging the fluxes of different ions which in turn controls various characteristics of capacitated spermatozoa. Alongwith the mobilization of ions the generation of free radicals and efflux of cholesterol also plays an impo~.nt role in thecapacitation state of the spermatozoa. The generation of free radical and efflux of cholesterol change the mechano-dynamic properties of the membrane by oxidation of the polyunsaturated lipids and by generating the cholesterol freepatches. The process of capacitation renders the spermatozoa responsive to the inducers of the acrosome reaction. Theglycoprotein zona pellucida 3 (ZP3) of the egg coat zona pellucida is the potent physiological stimulator of the acro-some reaction; progesterone, a major component of the follicular fluid, is also an inducer of the acrosome reaction.The inducers of the acrosome reaction cause the activation of the various ion-channels leading to high influxes of calci-um, sodium and bicarbonate. The efflux of cholesterol during the process of capacitation alters the permeability of themembrane to the ions and generate areas which are prone to fusion and ve.siculation process during the acrosome reactioa. this review focuses mainly on effects of the ion and ion-channels, free radicals, and membrane fluidity changesduring the process of capacitation and acrosome reaction.

  2. Radiation and radiation reaction in continuous focusing channels

    Huang, Zhirong; Chen, Pisin; Ruth, Ronald D.


    We show that the radiation damping rate of the transverse action of a particle in a straight, continuous focusing system is independent of the particle energy, and that no quantum excitation is induced. This absolute damping effect leads to the existence of a transverse ground state which the particle inevitably decays to, and yields the minimum beam emittance that one can ever attain, γɛmin=ℏ/2mc, limited only by the uncertainty principle. Due to adiabatic invariance, the particle can be accelerated along the focusing channel in its ground state without any radiation energy loss. These findings may apply to bent systems provided that the focusing field dominates over the bending field.

  3. State-to-state mode selectivity in the HD + OH reaction: Perspectives from two product channels

    Zhao, Bin; Sun, Zhigang; Guo, Hua


    The state-to-state quantum dynamics (Jtot = 0) of the HD + OH(υ2 = 0, 1) reaction is studied using a reactant coordinate based method, which allows the analysis of both the H + DOH and D + HOH channels with a single propagation. The stretching vibration of the newly formed bond, namely, the OD bond in DOH and one OH bond in HOH, is excited, thanks to its strong coupling with the reaction coordinate at the transition state. On the other hand, the vibrational energy deposited into the OH reactant (υ2 = 1) is sequestered during the reaction in the spectator OH mode. The combined effect leads to the excitation of both the OD and OH stretching modes in the DOH product, and the dominance of the (002) normal-mode state population in the HOH product, which in the local-mode picture corresponds to the excitation of both OH bonds with one quantum each. The energy flow in this prototypical tetratomic reaction can be understood in terms of the sudden vector projection model.

  4. Quantum and quasiclassical dynamics of the multi-channel H + H2S reaction

    Qi, Ji; Lu, Dandan; Song, Hongwei; Li, Jun; Yang, Minghui


    The prototypical multi-channel reaction H + H2S → H2 + SH/H + H2S has been investigated using the full-dimensional quantum scattering and quasi-classical trajectory methods to unveil the underlying competition mechanism between different product channels and the mode specificity. This reaction favors the abstraction channel over the exchange channel. For both channels, excitations in the two stretching modes promote the reaction with nearly equal efficiency and are more efficient than the bending mode excitation. However, they are all less efficient than the translational energy. In addition, the experimentally observed non-Arrhenius temperature dependence of the thermal rate constants is reasonably reproduced by the quantum dynamics calculations, confirming that the non-Arrhenius behavior is caused by the pronounced quantum tunneling.

  5. Dynamical coupled-channels study of meson production reactions from EBAC@Jlab

    Hiroyuki Kamano


    We present the current status of a combined and simultaneous analysis of meson production reactions based on a dynamical coupled-channels (DCC) model, which is conducted at Excited Baryon Analysis Center (EBAC) of Jefferson Lab.

  6. Coupled-channels description of the 40Ca+58,64Ni transfer and fusion reactions

    Scamps, G; Hagino, K; Haas, F; Courtin, S


    Preliminary experimental data for nucleon transfer reactions of the 40Ca+58Ni and 40Ca+64Ni systems are analyzed with the coupled- channels approach. It is shown that a simple treatment for the transfer in the coupled-channels method cannot reproduce simultaneously the transfer probabilities and the sub-barrier enhancement of fusion cross sections.

  7. Quantum Dynamics Study on D+OD+ Reaction: Competition between Exchange and Abstraction Channels

    Wen-wu Xu; Pei-yu Zhang; Guo-zhong He


    Quantum dynamics for the D+OD+ reaction at the collision energy range of 0.0-1.0 eV was studied on an accurate ab initio potential energy surface.Both of the endothermic abstraction (D+OD+-O++D2) and thermoneutral exchange (D+OD+-D+OD+) channels were investigated from the same set of time-dependent quantum wave packets method under centrifugal sudden approximation.The reaction probability dependence with collision energy,the integral cross sections,and the thermal rate constant of the both channels are calculated.It is found that there is a convex structure in the reaction path of the exchange reaction.The calculated time evolution of the wave packet distribution at J=0 clearly indicates that the convex structure significantly influences the dynamics of the exchange and abstraction channels of title reaction.

  8. Investigations on organolead compounds V. Lead---lead bond cleavage reactions of hexaphenyldilead

    Willemsens, L.C.; Kerk, G.J.M. van der


    It has been shown that a number of nucleophilic and weakly electrophilic reagents (organolithium and organomagnesium compounds, metallic lithium, potassium permanganate, sodium ethoxide, diaryl disulphides, sulphur, ozone, hypochlorous acid and iodine/iodide) selectively cleave the lead---lead bond

  9. Investigations on organolead compounds V. Lead---lead bond cleavage reactions of hexaphenyldilead

    Willemsens, L.C.; Kerk, G.J.M. van der

    It has been shown that a number of nucleophilic and weakly electrophilic reagents (organolithium and organomagnesium compounds, metallic lithium, potassium permanganate, sodium ethoxide, diaryl disulphides, sulphur, ozone, hypochlorous acid and iodine/iodide) selectively cleave the lead---lead bond

  10. Investigations on organolead compounds V. Lead---lead bond cleavage reactions of hexaphenyldilead

    Willemsens, L.C.; Kerk, G.J.M. van der


    It has been shown that a number of nucleophilic and weakly electrophilic reagents (organolithium and organomagnesium compounds, metallic lithium, potassium permanganate, sodium ethoxide, diaryl disulphides, sulphur, ozone, hypochlorous acid and iodine/iodide) selectively cleave the lead---lead bond

  11. Rare events via multiple reaction channels sampled by path replica exchange

    Bolhuis, P.G.


    Transition path sampling (TPS) was developed for studying activated processes in complex systems with unknown reaction coordinate. Transition interface sampling (TIS) allows efficient evaluation of the rate constants. However, when the transition can occur via more than one reaction channel separate

  12. Divergolide congeners illuminate alternative reaction channels for ansamycin diversification.

    Ding, Ling; Franke, Jakob; Hertweck, Christian


    Isolation and structure elucidation of six new divergolides reveal unusual ansamycin diversification reactions including formation of the unusual isobutenyl side chain from a branched polyketide synthase extender unit, azepinone ring closure, macrolide ring contraction and formation of a seco variant by a neighboring group-assisted decarboxylation.

  13. Mouse sperm patch-clamp recordings reveal single Cl- channels sensitive to niflumic acid, a blocker of the sperm acrosome reaction.

    Espinosa, F; de la Vega-Beltrán, J L; López-González, I; Delgado, R; Labarca, P; Darszon, A


    Ion channels lie at the heart of gamete signaling. Understanding their regulation will improve our knowledge of sperm physiology, and may lead to novel contraceptive strategies. Sperm are tiny (approximately 3 microm diameter) and, until now, direct evidence of ion channel activity in these cells was lacking. Using patch-clamp recording we document here, for the first time, the presence of cationic and anionic channels in mouse sperm. Anion selective channels were blocked by niflumic acid (NA) (IC50 = 11 microM). The blocker was effective also in inhibiting the acrosome reaction induced by the zona pellucida, GABA or progesterone. These observations suggest that Cl- channels participate in the sperm acrosome reaction in mammals.

  14. A semi-classical treatment of channeling radiation reaction

    Huang, Zhirong; Chen, Pisin; Ruth, Ronald D.


    A semi-classical formalism is used to calculate the radiation reaction of a relativistic particle in a straight, continuous focusing system. Due to the absence of quantum excitation in such a focusing system, the radiation damping rate of the transverse action obtained using this formalism agrees exactly with the result from the classical Lorentz-Dirac radiation reaction equation. In the limit where the pitch angle of the particle is much smaller than the radiation opening angle, the transverse action damps exponentially with an energy-independent rate that is much faster than the energy decay rate. In the opposite limit, both the transverse action and the energy damp with power laws and their relative rates are comparable. The general time-dependence of the transverse action damping and the energy decay are obtained analytically from these rate equations.

  15. Reduced Heat Flux Through Preferential Surface Reactions Leading to Vibrationally and Electronically Excited Product States


    AFRL-AFOSR-VA-TR-2016-0124 Reduced Heat Flux Through Preferential Surface Reactions Leading to Vibrationally and Electronically Excited Product...Reactions Leading to Vibrationally and Electronically Excited Product States 5a. CONTRACT NUMBER FA9550-12-1-0486 5b. GRANT NUMBER 5c. PROGRAM... Leading to Vibrationally and Electronically Excited Product States FINAL TECHNICAL REPORT: Grant #FA9550-12-1-0486 2013 Basic Research Initiative (BRI

  16. Formation of lead-aluminate ceramics: Reaction mechanisms in immobilizing the simulated lead sludge.

    Lu, Xingwen; Shih, Kaimin


    We investigated a strategy of blending lead-laden sludge and an aluminum-rich precursor to reduce the release of hazardous lead from the stabilized end products. To quantify lead transformation and determine its incorporation behavior, PbO was used to simulate the lead-laden sludge fired with γ-Al2O3 by Pb/Al molar ratios of 1/2 and 1/12 at 600-1000 °C for 0.25-10 h. The sintered products were identified and quantified using Rietveld refinement analysis of X-ray diffraction data from the products generated under different conditions. The results indicated that the different crystallochemical incorporations of hazardous lead occurred through the formation of PbAl2O4 and PbAl12O19 in systems with Pb/Al ratios of 1/2 and 1/12, respectively. PbAl2O4 was observed as the only product phase at temperature of 950 °C for 3h heating in Pb/Al of 1/2 system. For Pb/Al of 1/12 system, significant growth of the PbAl12O19 phase clearly occurred at 1000 °C for 3 h sintering. Different product microstructures were found in the sintered products between the systems with the Pb/Al ratios 1/2 and 1/12. The leaching performances of the PbO, Pb9Al8O21, PbAl2O4 and PbAl12O19 phases were compared using a constant pH 4.9 leaching test over 92 h. The leachability data indicated that the incorporation of lead into PbAl12O19 crystal is a preferred stabilization mechanism in aluminate-ceramics.

  17. [Role and function of voltage-gated chloride channels of the CIC family and their defects leading to genetic diseases].

    Dołowy, Krzysztof; Bednarczyk, Piotr; Hordejuk, Renata; Dworakowska, Beata; Nurowska, Ewa; Jarzabek, Wanda


    There are 9 channels of the ClC family in mammals and few others in fishes, plants, yeast and bacteria. The ClC channels are present in different tissues and play a role in transmembrane potential stabilization, transepithelial transport, cell volume regulation, acidification of intracellular organelles. The genetic defects of ClC-1 chloride channel lead to myotonias, the defect in ClC-5 channel to the formation of stones in kidney, while the defect in ClC-Kb channel leads to the Bartter's syndrome.

  18. Does centennial morphodynamic evolution lead to higher channel efficiency in San Pablo Bay, California?

    van der Wegen, M.; Jaffe, B.E.; Barnard, P.L.; Jaffee, B.E.; Schoellhamer, D.H.


    Measured bathymetries on 30 year interval over the past 150 years show that San Pablo Bay experienced periods of considerable deposition followed by periods of net erosion. However, the main channel in San Pablo Bay has continuously narrowed. The underlying mechanisms and consequences of this tidal channel evolution are not well understood. The central question of this study is whether tidal channels evolve towards a geometry that leads to more efficient hydraulic conveyance and sediment throughput. We applied a hydrodynamic process-based, numerical model (Delft3D), which was run on 5 San Pablo Bay bathymetries measured between 1856 and 1983. Model results shows increasing energy dissipation levels for lower water flows leading to an approximately 15% lower efficiency in 1983 compared to 1856. During the same period the relative seaward sediment throughput through the San Pablo Bay main channel increased by 10%. A probable explanation is that San Pablo Bay is still affected by the excessive historic sediment supply. Sea level rise and Delta surface water area variations over 150 years have limited effect on the model results. With expected lower sediment concentrations in the watershed and less impact of wind waves due to erosion of the shallow flats, it is possible that energy dissipations levels will decrease again in future decades. Our study suggests that the morphodynamic adaptation time scale to excessive variations in sediment supply to estuaries may be on the order of centuries.

  19. A Possible Reaction Channel from BrONO to BrNO2


    A possible isomerization channel from BrONO (bromine nitrite) to BrNO2 (nitryl bromide) is predicted by means of MP2 and QCISD(T) (single-point) methods. The channel is a direct bromine abstraction reaction from BrONO molecule by NO2 in which the forward reaction barrier is 89.30 kJ/mol at final UQCISD(T)/6-311+G(2df)//UMP2/6-311G(d) level of theory with zero-point energies included. The result can explain the available experiments very well.

  20. 33 CFR 162.260 - Channel leading to San Juan Harbor, P.R.; use, administration, and navigation.


    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Channel leading to San Juan Harbor, P.R.; use, administration, and navigation. 162.260 Section 162.260 Navigation and Navigable... WATERWAYS NAVIGATION REGULATIONS § 162.260 Channel leading to San Juan Harbor, P.R.; use, administration...

  1. Dynamical Coupled-Channel Model of Meson Production Reactions in the Nucleon Resonance Region

    T.-S. H. Lee; A. Matsuyama; T. Sato


    A dynamical coupled-channel model is presented for investigating the nucleon resonances (N*) in the meson production reactions induced by pions and photons. Our objective is to extract the N* parameters and to investigate the meson production reaction mechanisms for mapping out the quark-gluon substructure of N* from the data. The model is based on an energy-independent Hamiltonian which is derived from a set of Lagrangians by using a unitary transformation method.

  2. Numerical Simulations of Competitive-Consecutive Reactions in Turbulent Channel Flow

    Vrieling, A.J.


    This thesis deals with mixing of passive scalars in a turbulent flow. The passive scalars are released in a turbulent plane channel flow and interpreted as either non-reactive components or reactive components that are involved in a competitive-consecutive reaction system. The evolution of these pas

  3. A Proposed Reaction Channel for the Synthesis of the Superheavy Nucleus Z=109

    WANG Kun; MA Yu-Gang; MA Guo-Liang; WEI Yi-Bin; CAI Xiang-Zhou; CHEN Jin-Gen; GUO Wei; ZHONG Chen; SHEN Wen-Qing


    @@ We apply a statistical-evaporation model (HIVAP) to calculate the cross sections of superheavy elements, mainly about actinide targets and compare with some available experimental data. A reaction channel 30Si + 243Am is proposed for the synthesis of the element Z = 109 and the cross section is estimated.

  4. Chemical reaction and heat source effects on MHD oscillatory flow in an irregular channel

    P.V. Satya Narayana


    Full Text Available This paper investigates the effect of heat and mass transfer on MHD oscillatory flow in an asymmetric wavy channel with chemical reaction and heat source. The unsteadiness in the flow is due to an oscillatory pressure gradient across the ends of the channel. A magnetic field of uniform strength is applied in the direction perpendicular to the channel. However, the induced magnetic field is neglected due to the assumption of small magnetic Reynolds number. The temperature difference of the channel is also assumed high enough to induce heat transfer due to radiation. The governing equations are solved analytically by regular perturbation method. The analytical results are evaluated numerically and then are presented graphically to discuss the effects of different parameters entering into the problem. It is observed that the heat transport of a system is more increased in oscillatory flow than in ordinary conduction.

  5. Entrance Channel Stereospecificity of Photoinitiated H-Atom Reactions in Weakly Bonded Complexes

    Shin, Seung Koo; Chen, Y.; Oh, D.; Wittig, C.


    Hot H-atom reactions photoinitiated in T-shaped CO2-HBr and nearly-linear CO2-HCl complexes show remarkably different reaction probabilities. Broadside H-atom approaches in CO2-HBr complexes are greatly favoured over the relatively endon approaches of CO2-HCl complexes, a striking steric effect. Photoinitiated hot H-atom reactions with N2O result in a much lower [NH]/[OH] ratio with N2O-HI complexes than under single-collision conditions at the same photolysis wavelength. In addition, OH rotational distributions differ markedly between bulk and complexed conditions, while NH rotational distributions are similar. These results can be interpreted in terms of entrance channel stereospecificity influencing chemically distinct product channels.

  6. Influence of reaction channel on the isomeric cross-section ratio

    Qaim, S. M.; Sudár, S.; Fessler, A.


    The influence of reaction channel on the isomeric cross-section ratio was investigated by analysing the experimental data on the reactions Cr-52(p, n)Mn-52m,Mn-g, Cr-52(He-3, t)Mn-52m.g, Fe-54(d, alpha)Mn-52m.g, Fe-54(n, t)Mn-52m.g and Fe-54(He-3, alpha p)Mn-52m.g over the incident particle energy range extending up to 35MeV. The influence is most pronounced when the channels differ widely, for example (p,n) and (He-3, t) processes, i.e. when the reaction mechanisms are different. The nuclear...

  7. Study of angular momentum variation due to entrance channel effect in heavy ion fusion reactions

    Kumar, Ajay


    A systematic investigation of the properties of hot nuclei may be studied by detecting the evaporated particles. These emissions reflect the behavior of the nucleus at various stages of the deexcitation cascade. When the nucleus is formed by the collision of a heavy nucleus with a light particle, the statistical model has done a good job of predicting the distribution of evaporated particles when reasonable choices were made for the level densities and yrast lines. Comparison to more specific measurements could, of course, provide a more severe test of the model and enable one to identify the deviations from the statistical model as the signature of other effects not included in the model. Some papers have claimed that experimental evaporation spectra from heavy-ion fusion reactions at higher excitation energies and angular momenta are no longer consistent with the predictions of the standard statistical model. In order to confirm this prediction we have employed two systems, a mass-symmetric (31P+45Sc) and a mass-asymmetric channel (12C+64Zn), leading to the same compound nucleus 76Kr* at the excitation energy of 75 MeV. Neutron energy spectra of the asymmetric system (12C+64Zn) at different angles are well described by the statistical model predictions using the normal value of the level density parameter a = A/8 MeV-1. However, in the case of the symmetric system (31P+45Sc), the statistical model interpretation of the data requires the change in the value of a = A/10 MeV-1. The delayed evolution of the compound system in case of the symmetric 31P+45Sc system may lead to the formation of a temperature equilibrated dinuclear complex, which may be responsible for the neutron emission at higher temperature, while the protons and alpha particles are evaporated after neutron emission when the system is sufficiently cooled down and the higher g-values do not contribute in the formation of the compound nucleus for the symmetric entrance channel in case of charged

  8. The effect of lead on the photoelectric reaction of Zea mays L. plants.

    Pazurkiewicz-Kocot, K; Pietruszka, M


    We investigate the correlation between the concentrations of lead (10(-6)-10(-2) mol dm(-3) PbCl2) in the external medium and photoelectric reaction of Zea mays L. plants. The experiments were carried out on 8-10-day-old maize plants (Zea mays L. var. K33 x F2) with the use of conventional electrophysiological technique. The results suggest that in plants treated with lead ions the photoelectric reaction is significantly reduced. The pH variation of the incubation medium including the green fragments of leaves showed that lead ions caused inhibition of light-induced external acidification.

  9. Dynamical coupled-channel model of meson production reactions in the nucleon resonance region

    Matsuyama, A; Sato, T


    A dynamical coupled-channel model is presented for investigating the nucleon resonances in the meson production reactions induced by pions and photons. The model is based on an energy-independent Hamiltonian which is derived from a set of Lagrangians by using a unitary transformation method. By applying the projection operator techniques,we derive a set of coupled-channel equations which satisfy the unitarity conditions within the channel space spanned by the considered two-particle meson-baryon states and the three-particle $\\pi\\pi N$ state. We present and explain in detail a numerical method based on a spline-function expansion for solving the resulting coupled-channel equations which contain logarithmically divergent one-particle-exchange driving terms resulted from the $\\pi\\pi N$ unitarity cut. We show that this driving term can generate rapidly varying structure in the reaction amplitudes associated with the unstable particle channels. It also has large effects in determining the two-pion production cros...

  10. Present status of coupled-channels calculations for heavy-ion subbarrier fusion reactions

    Hagino, K


    The coupled-channels method has been a standard tool in analyzing heavy-ion fusion reactions at energies around the Coulomb barrier. We investigate three simplifications usually adopted in the coupled-channels calculations. These are i) the exclusion of non-collective excitations, ii) the assumption of coordinate independent coupling strengths, and iii) the harmonic oscillator approximation for multi-phonon excitations. In connection to the last point, we propose a novel microscopic method based on the beyond-mean-field approach in order to take into account the anharmonic effects of collective vibrations.

  11. Assessment of Lead and Beryllium deposition and adsorption to exposed stream channel sediments

    Pawlowski, E.; Karwan, D. L.


    The fallout radionuclides Beryllium-7 and Lead-210 have been shown to be effective sediment tracers that readily bind to particles. The adsorption capacity has primarily been assessed in marine and coastal environments with an important assumption being the radionuclides' uniform spatial distribution as fallout from the atmosphere. This neglects localized storm events that may mine stratospheric reserves creating variable distributions. To test this assumption atmospheric deposition is collected at the University of Minnesota St. Paul Campus weather station during individual storm events and subsequently analyzed for Beryllium-7 and Lead-210. This provides further insight into continental effects on radionuclide deposition. The study of Beryllium-7 and Lead-210 adsorption in marine and coastal environments has provided valuable insights into the processes that influence the element's binding to particles but research has been limited in freshwater river environments. These environments have greater variation in pH, iron oxide content, and dissolved organic carbon (DOC) levels which have been shown to influence the adsorption of Beryllium and Lead in marine settings. This research assesses the adsorption of Beryllium and Lead to river sediments collected from in-channel deposits by utilizing batch experiments that mimic the stream conditions from which the deposits were collected. Soils were collected from Difficult Run, VA, and the West Swan River, MN. Agitating the soils in a controlled solution of known background electrolyte and pH while varying the level of iron oxides and DOC in step provides a better understanding of the sorption of Lead and Beryllium under the conditions found within freshwater streams. Pairing the partitioning of Lead and Beryllium with their inputs to streams via depositional processes, from this study and others, allows for their assessment as possible sediment tracers and age-dating tools within the respective watersheds.

  12. Exit channel dynamics in a micro-hydrated SN2 reaction of the hydroxyl anion.

    Otto, R; Brox, J; Trippel, S; Stei, M; Best, T; Wester, R


    We report on the reaction dynamics of the monosolvated SN2 reaction of cold OH(-)(H2O) with CH3I that have been studied using crossed beam ion imaging. Two SN2 reaction channels are possible for this reaction: Formation of unsolvated I(-) and of solvated I(-)(H2O) products. We find a strong preference for the formation of unsolvated I(-) reaction products with respect to the energetically favored reaction toward solvated I(-)(H2O). Angle differential cross section measurements reveal similar velocity and angular distributions for all solvated and parts of the unsolvated reaction products. We furthermore find that the contribution of these two products to the total product flux can be described by the same collision energy dependence. We interpret our findings in terms of a joint reaction mechanism in which a CH3OH(H2O)···I(-) complex is formed that decays into either solvated or unsolvated products. Quantum chemical calculation are used to support this assumption.

  13. Dynamical coupled-channels study of pi N --> pi pi N reactions

    Kamano, H; Lee, T -S H; Matsuyama, A; Sato, T


    As a step toward performing a complete coupled-channels analysis of the world data of pi N, gamma^* N --> pi N, eta N, pi pi N reactions, the pi N --> pi pi N reactions are investigated starting with the dynamical coupled-channels model developed in Phys. Rev. C76, 065201 (2007). The channels included are pi N, eta N, and pi pi N which has pi Delta, rho N, and sigma N resonant components. The non-resonant amplitudes are generated from solving a set of coupled-channels equations with the meson-baryon potentials defined by effective Lagrangians. The resonant amplitudes are generated from 16 bare excited nucleon (N^*) states which are dressed by the non-resonant interactions as constrained by the unitarity condition. The available total cross section data of pi^+ p --> pi^+ pi^+ n, pi^+ pi^0p and pi^- p --> pi^+ pi^- n, pi^- pi^0 n, pi^0 pi^0 n can be reproduced to a very large extent both in magnitudes and energy-dependence. Possible improvements of the model are investigated, in particular on the role of the n...

  14. Quantifying the ionic reaction channels in the Secondary Organic Aerosol formation from glyoxal

    Maxut, Aurelia; Nozière, Barbara; Rossignol, Stéphanie; George, Christian; Waxman, Eleanor Marie; Laskin, Alexander; Slowik, Jay; Dommen, Josef; Prévôt, André; Baltensperger, Urs; Volkamer, Rainer


    Glyoxal, a common organic gas in the atmosphere, has been identified in recent years as an important Secondary Organic Aerosol (SOA) precursor (Volkamer et al., 2007). But, unlike with other precursors, the SOA is largely produced by particle-phase reactions (Volkamer et al., 2009) and equilibria (Kampf et al. 2013) that are still not entirely characterized. Since 2009 series of smog chamber experiments have been performed within the Eurochamp program at the Paul Scherrer Institute, Switzerland, to investigate SOA formation from glyoxal. In these experiments, glyoxal was produced by the gas-phase oxidation of acetylene in the presence of seeds, the seed composition and other conditions being varied. The 2011 campaign resulted in the identification of salting processes controlling the glyoxal partitioning in the seeds (Kampf et al. 2013). This presentation will report results of the 2013 campaign focusing on the identification of the various reactions (ionic or photo-induced) contributing to the SOA mass. In particular, the contribution of the ionic reactions, i.e. mediated by NH4+, were investigated by quantifying the formation of imidazoles (imidazole, imidazole-2-carboxaldehyde, 2,2'-biimidazole) from the small condensation channel of glyoxal with ammonia. For this, the SOA produced were collected on quartz filters and analyzed by Orbitrap LC/MS (Q-Exactive Thermo Fisher). The formation of other products such as organic acids was also investigated to determine potential competing reactions. Time-resolved MOUDI sampling coupled with nano-DESY/ESI-MS/MS analysis was also used to identify nitrogen- and sulphur-containing products from all the reactions. The results obtained for a range of conditions will be presented and compared with recent mechanistic information on the ionic reaction channels (Nozière et al., in preparation, 2013). The implementation of all this new information into a glyoxal-SOA model will be discussed.

  15. Solid-state reactions to synthesize nanostructured lead selenide semiconductor powders by high-energy milling

    Rojas-Chavez, H., E-mail: [Centro de Investigacion e Innovacion Tecnologica - IPN, Cerrada de CECATI s/n, Col. Santa Catarina, Del. Azcapotzalco (Mexico) and Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada - IPN, Legaria 694, Col. Irrigacion, Del. Miguel Hidalgo (Mexico); Reyes-Carmona, F. [Facultad de Quimica - UNAM, Circuito de la Investigacion Cientifica s/n, C.U. Del. Coyoacan (Mexico); Jaramillo-Vigueras, D. [Centro de Investigacion e Innovacion Tecnologica - IPN, Cerrada de CECATI s/n, Col. Santa Catarina, Del. Azcapotzalco (Mexico)


    Highlights: {yields} PbSe synthesized from PbO instead of Pb powder do not require an inert atmosphere. {yields} During high-energy milling oxygen has to be chemically reduced from the lead oxide. {yields} Solid-state and solid-gas chemical reactions promote both solid and gaseous products. -- Abstract: Both solid-solid and gas-solid reactions have been traced during high-energy milling of Se and PbO powders under vial (P, T) conditions in order to synthesize the PbSe phase. Chemical and thermodynamic arguments are postulated to discern the high-energy milling mechanism to transform PbO-Se micropowders onto PbSe-nanocrystals. A set of reactions were evaluated at around room temperature. Therefore an experimental campaign was designed to test the nature of reactions in the PbO-Se system during high-energy milling.

  16. Electrochemical reaction and performance of proton exchange membrane fuel cells with a novel cathode flow channel shape

    Chiang, Mu-Sheng [Department of Mechanical Engineering, National Chiao Tung University, Hsin-Chu 30010 (Taiwan); Department of Mechanical Engineering, Nan Kai Institute of Technology, Nantou 54243 (Taiwan); Chu, Hsin-Sen [Department of Mechanical Engineering, National Chiao Tung University, Hsin-Chu 30010 (Taiwan); Chen, Cha' o-Kuang [Department of Mechanical Engineering, National Cheng Kung University, Tainan 70101 (Taiwan); Jian, Sheng-Rui [Department of Electrophysics, National Chiao Tung University, Hsin-Chu 30010 (Taiwan)


    This study focuses on the investigation of the electrochemical reaction along a novel cathode flow channel of PEM fuel cells with various shoulder/channel (S/C) ratios at the outlet port. A three-dimensional mathematical model, considering conservation principles of mass, momentum, species and electric current is employed. Local variations of important model variables such as reactant concentration and local current density are presented by contour plots to elucidate the effects of channel geometry on transport process, catalyst reaction and cell performance. The potential fields of solid and membrane phases are also resolved in the cell domain and the driving force of the electrochemical reactions - the catalyst activation overpotential - is harnessed in modeling. Numerical calculations reveal the influence of the cathode channel configuration on the local distributions of various model variables. The results also show the dependence between optimal channel configuration and cell operating condition. At a medium reaction rate, the reaction sites underneath the shoulder region generate more current than the channel region. Therefore, a convergent channel configuration with a larger S/C ratio at the outlet port develops more current because such a design facilitates the electron transport and enhances local activation overpotential. However, as the cell voltage decreases and the reaction rate increases, such configuration loses its merit gradually as the requirement for a higher reactant concentration is more important and the reaction sites underneath the channel region have a higher reaction rate. Consequently, the divergent channel configuration with a lower S/C ratio of 0.67 performs better at a cell voltage of 0.22 V. (author)

  17. Effects of entrance channel on fusion probability in hot fusion reactions

    Zhu, Long; Huang, Ching-Yuan; Zhang, Feng-Shou


    Within the framework of the dinuclear system (DNS) model, the fusion reactions leading to the compound nuclei 274Hs and 286Cn are investigated. The fusion probability as a function of DNS excitation energy is studied. The calculated results are in good agreement with the available experimental data. The obtained results show that the fusion probabilities are obviously enhanced for the reactions located at high place in potential energy surface, although these reactions may have small values of mass asymmetry. It is found that the enhancement is due to the large potential energy of the initial DNS.

  18. Effects of inorganic lead on voltage-sensitive calcium channels in N1E-115 neuroblastoma cells.

    Audesirk, G; Audesirk, T


    N1E-115 mouse neuroblastoma cells have been reported to possess two types of voltage-sensitive calcium channels: Low voltage activated, rapidly inactivating T-type (type I) and high voltage activated, slowly inactivating L-type (type II). We studied the effects of acute in vitro exposure to inorganic lead on these calcium channels, using the whole-cell variant of patch clamping. Using salines with a high lead-buffering capacity, we found that both T-type and L-type channels are reversibly inhibited in a dose-dependent manner at free Pb2+ concentrations ranging from 20 nM to 14 microM. L-type channels are somewhat more sensitive to Pb2+ than T-type channels are (L-type: IC50 approx. 0.7 microM; T-type: IC50 approx. 1.3 microM). Both channels show small but significant inhibition (approx. 10%) at 20 nM free Pb2+. Pb2+ affects neither activation nor inactivation of T-type channels, but enhances inactivation of L-type channels at holding potentials around -60 to -40 mV. A peculiar phenomenon was observed in cells exposed to 2.3 microM free Pb2+. T-type channels were inhibited in all 20 cells studied. In 15 cells, L-type channels were also inhibited, but in the remaining 5 cells, current flow through L-type channels was enhanced by Pb2+ exposure.

  19. Information theory and statistical nuclear reactions. I. General theory and applications to few-channel problems

    Mello, P.A.; Pereyra, P.; Seligman, T.H.


    Ensembles of scattering S-matrices have been used in the past to describe the statistical fluctuations exhibited by many nuclear-reaction cross sections as a function of energy. In recent years, there have been attempts to construct these ensembles explicitly in terms of S, by directly proposinng a statistical law for S. In the present paper, it is shown that, for an arbitrary number of channels, one can incorporate, in the ensemble of S-matrices, the conditions of flux conservation, time-reversal invariance, causality, ergodicity, and the requirement that the ensemble average coincide with the optical scattering matrix. Since these conditions do not specify the ensemble uniquely, the ensemble that has maximum information-entropy is dealt with among those that satisfy the above requirements. Some applications to few-channel problems and comparisons to Monte-Carlo calculations are presented.

  20. Electrophysiology of lead intoxication: effects on voltage-sensitive ion channels.

    Audesirk, G


    Neuronal function depends on the activity of a variety of voltage-sensitive, ion-specific membrane channels, including channels permeable chiefly to sodium, potassium, and calcium. The plasma membranes of many neurons contain several types of each class of channel. In general, heavy metal ions exert little effect on voltage-sensitive sodium or potassium channels, but inhibit ion flow through voltage-sensitive calcium channels (VSCC). The literature abounds with descriptions of different types of calcium channels in vertebrate neurons. These descriptions suggest that there are many physiologically and pharmacologically distinct calcium channels, some of them possibly cell-type specific. Among the heavy metals, Pb2+ is one of the most potent inhibitors of VSCC in both vertebrate and invertebrate neurons. Some heavy metals, including Ni2+ and Cd2+, are fairly selective against certain types of calcium channels. Limited evidence suggests that Pb2+ inhibits all calcium channel types within a given cell, with only minor differences in potency. However, there appear to be substantial differences among cell types in the concentration dependence of calcium channel inhibition by Pb2+. Therefore, to appreciate the range of effects of Pb2+ on calcium channels throughout the nervous system, it will be important to examine a large number of cell types. Pb2+ is highly permeable through at least some types of VSCC. Entry of Pb2+ into the neuronal cytoplasm through VSCC, followed by disturbance of intracellular functions, may be a major mechanism of Pb2+ neurotoxicity.

  1. Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.

    Klint, Julie K; Senff, Sebastian; Rupasinghe, Darshani B; Er, Sing Yan; Herzig, Volker; Nicholson, Graham M; King, Glenn F


    Voltage-gated sodium (Na(V)) channels play a central role in the propagation of action potentials in excitable cells in both humans and insects. Many venomous animals have therefore evolved toxins that modulate the activity of Na(V) channels in order to subdue their prey and deter predators. Spider venoms in particular are rich in Na(V) channel modulators, with one-third of all known ion channel toxins from spider venoms acting on Na(V) channels. Here we review the landscape of spider-venom peptides that have so far been described to target vertebrate or invertebrate Na(V) channels. These peptides fall into 12 distinct families based on their primary structure and cysteine scaffold. Some of these peptides have become useful pharmacological tools, while others have potential as therapeutic leads because they target specific Na(V) channel subtypes that are considered to be important analgesic targets. Spider venoms are conservatively predicted to contain more than 10 million bioactive peptides and so far only 0.01% of this diversity been characterised. Thus, it is likely that future research will reveal additional structural classes of spider-venom peptides that target Na(V) channels.

  2. Lead

    ... found? Who is at risk? What are the health effects of lead? Get educational material about lead Get certified as a Lead Abatement Worker, or other abatement discipline Lead in drinking water Lead air pollution Test your child Check and maintain your home ...

  3. Effects of entrance channel on fusion probability in hot fusion reactions

    Zhu, Long; Su, Jun; Huang, Ching-Yuan; Zhang, Feng-Shou


    Within the framework of the dinuclear system (DNS) model, the fusion reactions leading to the compound nuclei 274Hs* and 286Cn* are investigated. The fusion probability as a function of DNS excitation energy is studied. The calculated results are in good agreement with the available experimental data. The obtained results show that the fusion probabilities are obviously enhanced for the reactions located at high place in potential energy surface, although these reactions may have small values of mass asymmetry. It is found that the enhancement is due to the large potential energy of the initial DNS. Supported by Natural Science Foundation of Guangdong Province China (2016A030310208). National Natural Science Foundation of China (11605296, 11405278, 11505150, 11635003), Fundamental Research Funds for the Central Universities (15 lgpy 30) and China Postdoctoral Science Foundation (2015M582730)

  4. Theoretical Study on Reaction Pathways Leading to CO and CO2 in the Pyrolysis of Resorcinol.

    Furutani, Yuki; Kudo, Shinji; Hayashi, Jun-Ichiro; Norinaga, Koyo


    Possible pathways for the pyrolysis of resorcinol with the formation of CO and CO2 as final products were proposed and evaluated using ab initio calculations. Our experimental study revealed that large quantities of CO2 are generated in the pyrolysis of 1,3-dihydroxybenzene (resorcinol), while the pyrolysis of the dihydroxybenzene isomers 1,2-dihydroxybenzene (catechol) and 1,4-dihydroxybenzene (hydroquinone) produces little CO2. The fate of oxygen atoms in catechol and hydroquinone was essentially the formation of CO. In the proposed pathways, the triplet ground state m-benzoquinone was generated initially from simultaneous cleavage of the two O-H bonds in resorcinol. Subsequently, the direct cleavage of a C-C bond of the m-benzoquinone diradical yields 2-oxidanylcyclopenta-2,4-dien-1-yl-methanone, which can be converted via two channels: release of CO from the aldehyde radical group and combination of the ketone radical and carbon atom in the aldehyde radical group to form the 6-oxabicyclo[3.2.0]hepta-2,4-dien-7-one, resulting in the release of CO2. Potential energy surfaces along the proposed reaction pathways were calculated employing the CBS-QB3 method, and the rate constants at the high-pressure limit were also evaluated based on transition-state theory to assess the feasibility of the proposed reaction pathways.

  5. Thermochemical reaction mechanism of lead oxide with poly(vinyl chloride) in waste thermal treatment.

    Wang, Si-Jia; Zhang, Hua; Shao, Li-Ming; Liu, Shu-Meng; He, Pin-Jing


    Poly(vinyl chloride) (PVC) as a widely used plastic that can promote the volatilization of heavy metals during the thermal treatment of solid waste, thus leading to environmental problems of heavy metal contamination. In this study, thermogravimetric analysis (TGA) coupled with differential scanning calorimeter, TGA coupled with Fourier transform infrared spectroscopy and lab-scale tube furnace experiments were carried out with standard PVC and PbO to explicate the thermochemical reaction mechanism of PVC with semi-volatile lead. The results showed that PVC lost weight from 225 to 230°C under both air and nitrogen with an endothermic peak, and HCl and benzene release were also detected. When PbO was present, HCl that decomposed from PVC instantly reacted with PbO via an exothermal gas-solid reaction. The product was solid-state PbCl2 at 501°C, PbCl2 melted, volatilized and transferred into flue gas or condensed into fly ash. Almost all PbCl2 volatilized above 900°C, while PbO just started to volatilize slowly at this temperature. Therefore, the chlorination effect of PVC on lead was apt to lower-temperature and rapid. Without oxygen, Pb2O was generated due to the deoxidizing by carbon, with oxygen, the amount of residual Pb in the bottom ash was significantly decreased.

  6. Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis.

    Colletti, Grace A; Miedel, Mark T; Quinn, James; Andharia, Neel; Weisz, Ora A; Kiselyov, Kirill


    Mucolipidosis type IV (MLIV) is a lysosomal storage disease caused by mutations in the gene MCOLN1, which codes for the transient receptor potential family ion channel TRPML1. MLIV has an early onset and is characterized by developmental delays, motor and cognitive deficiencies, gastric abnormalities, retinal degeneration, and corneal cloudiness. The degenerative aspects of MLIV have been attributed to cell death, whose mechanisms remain to be delineated in MLIV and in most other storage diseases. Here we report that an acute siRNA-mediated loss of TRPML1 specifically causes a leak of lysosomal protease cathepsin B (CatB) into the cytoplasm. CatB leak is associated with apoptosis, which can be prevented by CatB inhibition. Inhibition of the proapoptotic protein Bax prevents TRPML1 KD-mediated apoptosis but does not prevent cytosolic release of CatB. This is the first evidence of a mechanistic link between acute TRPML1 loss and cell death.

  7. Pacing Lead-Induced Granuloma in the Atrium: A Foreign Body Reaction to Polyurethane

    Shinagawa Yoko


    Full Text Available We described a case of an 82-year-old male who presented with a granuloma entrapping the polyurethane-coated pacing lead at the site of contact on the atrium. He had been paced for 8 years without symptoms or signs suggestive of an allergic reaction to the pacemaker system and died from thrombosis of the superior mesenteric artery and heart failure. A histological examination of the nodule showed an incidental granuloma with multinucleated giant cells. No granuloma was found in the heart or the lung.

  8. Molecular Mechanism that Leads to Development of Epilepsy by a Sodium Channel Mutation

    Velazquez, Eric


    The number of mutations in the voltage-gated sodium channel Nav1.1, encoded by SCN1A, that have been associated with genetic epilepsy is extremely high compared to the other sodium channel genes. The crucial function of the voltage-gated sodium channels in the central nervous system (CNS) is to regulate the influx of sodium or sodium current into the neurons. Sodium currents are required for the generation and propagation of action potentials. Subsequently the action potentials cause the rele...

  9. Bulge formed cooling channels with a variable lead helix on a hollow body of revolution

    McAninch, Michael D. (Inventor); Holbrook, Richard L. (Inventor); Lacount, Dale F. (Inventor); Kawashige, Chester M. (Inventor); Crapuchettes, John M. (Inventor); Scala, James (Inventor)


    A method of constructing a nozzle having cooling channels comprises a shell and a liner which are formed into a body of revolution having an axis of revolution. Helical welds are formed to hold the liner and shell to each other with a channel position being defined between each pair of helical welds. Pressurized fluid which may be a gas or a liquid, is introduced between the weld pairs to outwardly bulge the material of at least one of the liner and shell to define the channels.

  10. Tuning the Optical Properties of Cesium Lead Halide Perovskite Nanocrystals by Anion Exchange Reactions.

    Akkerman, Quinten A; D'Innocenzo, Valerio; Accornero, Sara; Scarpellini, Alice; Petrozza, Annamaria; Prato, Mirko; Manna, Liberato


    We demonstrate that, via controlled anion exchange reactions using a range of different halide precursors, we can finely tune the chemical composition and the optical properties of presynthesized colloidal cesium lead halide perovskite nanocrystals (NCs), from green emitting CsPbBr3 to bright emitters in any other region of the visible spectrum, and back, by displacement of Cl(-) or I(-) ions and reinsertion of Br(-) ions. This approach gives access to perovskite semiconductor NCs with both structural and optical qualities comparable to those of directly synthesized NCs. We also show that anion exchange is a dynamic process that takes place in solution between NCs. Therefore, by mixing solutions containing perovskite NCs emitting in different spectral ranges (due to different halide compositions) their mutual fast exchange dynamics leads to homogenization in their composition, resulting in NCs emitting in a narrow spectral region that is intermediate between those of the parent nanoparticles.

  11. Investigating multi-channel quantum tunneling in heavy-ion fusion reactions with Bayesian spectral decomposition

    Hagino, K


    Excitations of colliding nuclei during a nuclear reaction considerably affect fusion cross sections at energies around the Coulomb barrier. It has been demonstrated that such channel coupling effects can be represented in terms of a distribution of multiple fusion barriers. We here apply a Bayesian approach to analyze the so called fusion barrier distributions. This method determines simultaneously the barrier parameters and the number of barriers. We particularly investigate the $^{16}$O+$^{144}$Sm and $^{16}$O+$^{154}$Sm systems in order to demonstrate the effectiveness of the method. The present analysis indicates that the fusion barrier distribution for the former system is most consistent with three fusion barriers, even though the experimental data show only two distinct peaks.

  12. Rational design, synthesis of reaction-based dual-channel cyanide sensor in aqueous solution

    Li, Jun-Jian; Wei, Wei; Qi, Xiao-Liang; Xu, Xiao; Liu, Yu-Cheng; Lin, Qiu-Han; Dong, Wei


    A new dual-channel sensor for the detection of cyanide was developed based on the conjugated of naphthalene and malononitrile. Upon the addition of CN-, the sensor displayed very large blue-shift in both fluorescence (80 nm) and absorption (120 nm) spectra. The sensor of cyanide was performed via the nucleophilic attack of cyanide anion to vinylic groups of the sensor with a 1:1 binding stoichiometry and the color changed of the sensor is mainly due to the intramolecular charge transfer process improvement. The intramolecular charge transfer progress was blocked with color changed and fluorescence blue-shift. The mechanism of sensor reaction with CN- ion was studied using 1H NMR and mass spectrometry.

  13. The reactions of O({sup 3}P) with alkenes: The formyl radical channel

    Min, Z.; Wong, T.H.; Quandt, R.; Bersohn, R.


    The HCO product of the reaction of O({sup 3}P) with ethene has been detected by cavity ring-down spectroscopy using its A-X transition. For propene a somewhat smaller yield of HCO was obtained but the overall rate constant is much larger. The yield of HCO in this reaction is quite small ({approximately}0.05). Moreover, a large number of other alkenes were tried with negative results. The failure of the 1,2 H atom shift followed by breaking the 1,2 bond implies that the unimolecular decomposition has found a more favorable channel. The proposed mechanism is as follows. For an alkene of the form RCH{sub 2}{double{underscore}bond}CH{sub 2} the first step is attachment of the O({sup 3}P) to the terminal carbon atom, C{sub 1}. Then, intersystem crossing occurs and finally a H atom shifts from C{sub 3} to C{sub 2} and not from C{sub 1} to C{sub 2}. In this way a molecule of formaldehyde and an alkene shorter by one carbon atom are formed.

  14. Perspective on the reactions between F- and CH3CH2F: the free energy landscape of the E2 and SN2 reaction channels.

    Ensing, Bernd; Klein, Michael L


    Recently, we computed the 3D free energy surface of the base-induced elimination reaction between F(-) and CH(3)CH(2)F by using a powerful technique within Car-Parrinello molecular dynamics simulation. Here, the set of three order parameters is expanded to six, which allows the study of the competing elimination and substitution reactions simultaneously. The power of the method is exemplified by the exploration of the six-dimensional free energy landscape, sampling, and mapping out the eight stable states as well as the connecting bottlenecks. The free energy profile and barrier along the E2 and S(N)2 reaction channels are refined by using umbrella sampling. The two mechanisms do not share a common "E2C-like" transition state. Comparison with the zero temperature profiles shows a particularly significant entropy contribution to the S(N)2 channel.

  15. Stimulation of TRPC5 cationic channels by low micromolar concentrations of lead ions (Pb{sup 2+})

    Sukumar, Piruthivi [Multidisciplinary Cardiovascular Research Centre and Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT (United Kingdom); Beech, David J., E-mail: [Multidisciplinary Cardiovascular Research Centre and Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT (United Kingdom)


    Lead toxicity is long-recognised but continues to be a major public health problem. Its effects are wide-ranging and include induction of hyper-anxiety states. In general it is thought to act by interfering with Ca{sup 2+} signalling but specific targets are not clearly identified. Transient receptor potential canonical 5 (TRPC5) is a Ca{sup 2+}-permeable ion channel that is linked positively to innate fear responses and unusual amongst ion channels in being stimulated by trivalent lanthanides, which include gadolinium. Here we show investigation of the effect of lead, which is a divalent ion (Pb{sup 2+}). Intracellular Ca{sup 2+} and whole-cell patch-clamp recordings were performed on HEK 293 cells conditionally over-expressing TRPC5 or other TRP channels. Extracellular application of Pb{sup 2+} stimulated TRPC5 at concentrations greater than 1 {mu}M. Control cells without TRPC5 showed little or no response to Pb{sup 2+} and expression of other TRP channels (TRPM2 or TRPM3) revealed partial inhibition by 10 {mu}M Pb{sup 2+}. The stimulatory effect on TRPC5 depended on an extracellular residue (E543) near the ion pore: similar to gadolinium action, E543Q TRPC5 was resistant to Pb{sup 2+} but showed normal stimulation by the receptor agonist sphingosine-1-phosphate. The study shows that Pb{sup 2+} is a relatively potent stimulator of the TRPC5 channel, generating the hypothesis that a function of the channel is to sense metal ion poisoning.

  16. Lead 207, 208 (n, xn gamma) reactions for neutron energies up to 200 MeV

    Pavlik, A.; Vonach, H. [Univ. Wien (Austria). Inst. fuer Radiumforschung und Kernphysik; Chadwick, M.B.; Haight, R.C.; Nelson, R.O.; Wender, S.A.; Young, P.G. [Los Alamos National Lab., NM (United States)


    High-resolution {gamma}-ray spectra from the interaction of neutrons in the energy range from 3 to 200 MeV with {sup 207,208}Pb were measured with the white neutron source at the WNR facility at Los Alamos National Laboratory. From these data, excitation functions for prominent {gamma} transitions in {sup 200,202,204,206,207,208}Pb were derived from threshold to 200 MeV incident neutron energy. These {gamma}-production cross sections represent formation cross sections for excited states of the residual nuclei. The results are compared with the predictions of nuclear reaction calculations based on the exciton model for precompound emission, the Hauser-Feshbach theory for compound nuclear decay, and coupled channels calculations to account for direct excitation of collective levels. Good agreement was obtained over the entire energy range covered in the experiment with reasonable model parameters. The results demonstrate that multiple preequilibrium emission has to be taken into account above about 40 MeV, and that the level density model of Ignatyuk should be used instead of the Gilbert-Cameron and back-shifted Fermi-gas models if excitation energies exceed about 30 MeV.

  17. Malignant hyperthermia-like reaction in a family with a sodium channel mutation at residue 1306

    Vita, G.M.; Jedlicka, A.E.; Levitt, R.C. [Johns Hopkins Medical Institute, Baltimore, MD (United States)] [and others


    Malignant hyperthermia susceptibility (MHS) is an autosomal dominant, hypermetabolic disorder, triggered by potent inhalational anesthetics. We have previously suggeste the skeletal muscle sodium channel {alpha}-subunit (SCN4A) as a gene candidate to explain some forms of MHS. To evaluate this gene for mutations that might lead to a MHS-like episode, we amplified genomic DNA by PCR and used SSCP to screen each exon. We studied multiple MHS families which may be linked to this gene. The proband and a sibling from one of these families suspected of having MHS experienced trismus and body rigidity after induction of anesthesia. The caffiene and halothane contracture test proved diagnostic in these individuals and EMG studies suggested a form of myotomia. A mutation co-segregating with the myotonia/MHS phenotype was found in the region of exon 22.

  18. Interfacial Reaction of Sn-Ag-Cu Lead-Free Solder Alloy on Cu: A Review

    Liu Mei Lee


    Full Text Available This paper reviews the function and importance of Sn-Ag-Cu solder alloys in electronics industry and the interfacial reaction of Sn-Ag-Cu/Cu solder joint at various solder forms and solder reflow conditions. The Sn-Ag-Cu solder alloys are examined in bulk and in thin film. It then examines the effect of soldering conditions to the formation of intermetallic compounds such as Cu substrate selection, structural phases, morphology evolution, the growth kinetics, temperature and time is also discussed. Sn-Ag-Cu lead-free solder alloys are the most promising candidate for the replacement of Sn-Pb solders in modern microelectronic technology. Sn-Ag-Cu solders could possibly be considered and adapted in miniaturization technologies. Therefore, this paper should be of great interest to a large selection of electronics interconnect materials, reliability, processes, and assembly community.

  19. Lead

    ... Chapter 6 Chapter 7 Chapter 8 Chapter 9 Appendix I Appendix II Tables Figures State Programs Alabama Alaska Arizona ... Tool Kit Resources Healthy Homes and Lead Poisoning Prevention Training Center (HHLPPTC) Training Tracks File Formats Help: ...

  20. Observation of H displacement and H2 elimination channels in the reaction of O(3P) with 1-butene from crossed beams and theoretical studies

    Caracciolo, Adriana; Vanuzzo, Gianmarco; Balucani, Nadia; Stranges, Domenico; Cavallotti, Carlo; Casavecchia, Piergiorgio


    We report preliminary combined experimental/theoretical results on O(3P) + 1-butene reaction dynamics with focus on atomic hydrogen displacement and molecular hydrogen elimination channels. Dynamics and relative yield of the ethylvinoxy + H and ethylketene + H2 product channels are characterized in crossed beam experiments. Stationary points and energetics of triplet/singlet C4H8O potential energy surfaces (PESs) are calculated at CCSD(T)/CBS and CASPT2 level. O(3P) attack occurs on both unsaturated C-atoms with preference for the less substituted one leading, among other products, to C2H5CHCHO + H via an exit barrier on the triplet PES, and to C2H5CHCO + H2 via a very high exit barrier on the singlet PES following intersystem crossing.

  1. Fusion and neutron transfer reactions with weakly bound nuclei within time-dependent and coupled channel approaches

    Samarin, V. V.


    The time-dependent Schrödinger equation and the coupled channel approach based on the method of perturbed stationary two-center states are used to describe nucleon transfers and fusion in low-energy nuclear reactions. Results of the cross sections calculation for the formation of the 198Au and fusion in the 6He+197Au reaction and for the formation of the 65Zn in 6He+64Zn reaction agree satisfactorily with the experimental data near the barrier. The Feynman's continual integrals calculations for a few-body systems were used for the proposal of the new form of the shell model mean field for helium isotopes.

  2. The C(3P) + NH3 reaction in interstellar chemistry: I. Investigation of the product formation channels

    Bourgalais, Jeremy; Kailasanathan, Ranjith Kumar Abhinavam; Osborn, David L; Hickson, Kevin M; Loison, Jean-Christophe; Wakelam, Valentine; Goulay, Fabien; Picard, Sébastien D Le


    The product formation channels of ground state carbon atoms, C(3P), reacting with ammonia, NH3, have been investigated using two complementary experiments and electronic structure calculations. Reaction products are detected in a gas flow tube experiment (330 K, 4 Torr) using tunable VUV photoionization coupled with time of flight mass spectrometry. Temporal profiles of the species formed and photoionization spectra are used to identify primary products of the C + NH3 reaction. In addition, H-atom formation is monitored by VUV laser induced fluorescence from room temperature to 50 K in a supersonic gas flow generated by the Laval nozzle technique. Electronic structure calculations are performed to derive intermediates, transition states and complexes formed along the reaction coordinate. The combination of photoionization and laser induced fluorescence experiments supported by theoretical calculations indicate that in the temperature and pressure range investigated, the H + H2CN production channel represents ...

  3. Four-body continuum-discretized coupled-channels calculations applied to {sup 6}He reactions

    Rodriguez-Gallardo, M. [Consejo Superior de Investigaciones Cientificas (CSIC), Madrid (Spain). Inst. de Estructura de la Materia; Arias, J.M.; Gomez-Camacho, J.M.; Moro, A.M. [Universidad de Sevilla (Spain). Dept. de Fisica Atomica, Molecular y Nuclear; Thompson, I.J. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Physical Science Directorate; Tostevin, J.A. [University of Surrey, Guildford (United Kingdom). Dept. of Physics


    Full text. The scattering of a weakly bound three-body system by a target is discussed. The continuum-discretized coupled-channels (CDCC) framework, recently extended to four-body reactions (three-body projectile plus target), is used for the scattering calculations. Two different methods are used to discretized the three-body continuum of the projectile. In the first case, we make use of a Pseudo-State (PS) method in which the states of the projectile are represented by the eigenstates of its internal Hamiltonian in a truncated basis of square-integrable functions. In particular, we use the transformed harmonic oscillator (THO) method, in which the PS basis is obtained by applying a local scale transformation to the Harmonic Oscillator basis. In the second case, we applied the binning procedure that has just been extended to three-body projectiles. This discretization method requires to calculate first the true continuum of the projectile and then this continuum is discretized making bins or packages of energy. This has been the method used for many years in standard three-body (two-body projectile plus target) CDCC calculations. Its extension to three-body projectiles uses the eigenchannel expansion of the three-body S-matrix. We applied this formalism to several reactions induced by the Borromean nucleus {sup 6}He at different energies, namely {sup 6}He+{sup 9}Be at 16.2 MeV, {sup 6}He+{sup 64}Zn at 13.6 MeV, {sup 6}He+{sup 120}Sn at 17.4 MeV, and {sup 6}He+{sup 208}Pb at 22 MeV. Four-body CDCC calculations for elastic and breakup observables are presented for these reactions comparing both discretization methods, THO and binning. The effect of the mass of the target, which is clearly related to the influence of Coulomb couplings, is investigated. The elastic cross sections are also compared to existing experimental data. (author)

  4. Size and asymmetry of the reaction entrance channel: influence on the probability of neck production

    Milazzo, P M; Agodi, C; Alba, R; Bellia, G; Colonna, N; Coniglione, R; Zoppo, A D; Finocchiaro, P; Gramegna, F; Iori, I; Maiolino, C; Margagliotti, G V; Mastinu, P F; Migneco, E; Moroni, A; Piattelli, P; Rui, R; Santonocito, D; Sapienza, P


    The results of experiments performed to investigate the Ni+Al, Ni+Ni, Ni+Ag reactions at 30 MeV/nucleon are presented. From the study of dissipative midperipheral collisions, it has been possible to detect events in which Intermediate Mass Fragments (IMF) production takes place. The decay of a quasi-projectile has been identified; its excitation energy leads to a multifragmentation totally described in terms of a statistical disassembly of a thermalized system (T$\\simeq$4 MeV, E$^*\\simeq$4 MeV/nucleon). Moreover, for the systems Ni+Ni, Ni+Ag, in the same nuclear reaction, a source with velocity intermediate between that of the quasi-projectile and that of the quasi-target, emitting IMF, is observed. The fragments produced by this source are more neutron rich than the average matter of the overall system, and have a charge distribution different, with respect to those statistically emitted from the quasi-projectile. The above features can be considered as a signature of the dynamical origin of the midvelocity ...

  5. Quasifission and fusion-fission in massive nuclei reactions. Comparison of reactions leading to the Z=120 element

    Nasirov, A K; Hanappe, F; Heinz, S; Hofmann, S; Mandaglio, G; Manganaro, M; Muminov, A I; Scheid, W


    The yields of evaporation residues, fusion-fission and quasifission fragments in the $^{48}$Ca+$^{144,154}$Sm and $^{16}$O+$^{186}$W reactions are analyzed in the framework of the combined theoretical method based on the dinuclear system concept and advanced statistical model. The measured yields of evaporation residues for the $^{48}$Ca+$^{154}$Sm reaction can be well reproduced. The measured yields of fission fragments are decomposed into contributions coming from fusion-fission, quasifission, and fast-fission. The decrease in the measured yield of quasifission fragments in $^{48}$Ca+$^{154}$Sm at the large collision energies and the lack of quasifission fragments in the $^{48}$Ca+$^{144}$Sm reaction are explained by the overlap in mass-angle distributions of the quasifission and fusion-fission fragments. The investigation of the optimal conditions for the synthesis of the new element $Z$=120 ($A$=302) show that the $^{54}$Cr+$^{248}$Cm reaction is preferable in comparison with the $^{58}$Fe+$^{244}$Pu and ...

  6. New MCRs: The first 4-component reaction leading to 2,4-disubstituted thiazoles

    Kolb, Jürgen; Beck, Barbara; Almstetter, Michael; Heck, Stefan; Herdtweck, Eberhardt; Dömling, Alexander


    New organic reactions allow chemical transformations which were previously not possible. Therefore, new reactions are important contributions to the progress in the field of organic synthesis. In this series we describe the design, scope, and limitations of newly-discovered multi-component reactions

  7. Impact of the new HNO3-forming channel of the HO2+NO reaction on tropospheric HNO3, NOx, HOx and ozone

    A. Kukui


    Full Text Available We have studied the impact of the recently observed reaction NO+HO2→HNO3 on atmospheric chemistry. A pressure and temperature-dependent parameterisation of this minor channel of the NO+HO2→NO2+OH reaction has been included in both a 2-D stratosphere-troposphere model and a 3-D tropospheric chemical transport model (CTM. Significant effects on the nitrogen species and hydroxyl radical concentrations are found throughout the troposphere, with the largest percentage changes occurring in the tropical upper troposphere (UT. Including the reaction leads to a reduction in NOx everywhere in the troposphere, with the largest decrease of 25% in the tropical and Southern Hemisphere UT. The tropical UT also has a corresponding large increase in HNO3 of 25%. OH decreases throughout the troposphere with the largest reduction of over 20% in the tropical UT. The mean global decrease in OH is around 13%, which is very large compared to the impact that typical photochemical revisions have on this modelled quantity. This OH decrease leads to an increase in CH4 lifetime of 5%. Due to the impact of decreased NOx on the OH:HO2 partitioning, modelled HO2 actually increases in the tropical UT on including the new reaction. The impact on tropospheric ozone is a decrease in the range 5 to 12%, with the largest impact in the tropics and Southern Hemisphere. Comparison with observations shows that in the region of largest changes, i.e. the tropical UT, the inclusion of the new reaction tends to degrade the model agreement. Elsewhere the model comparisons are not able to critically assess the impact of including this reaction. Only small changes are calculated in the minor species distributions in the stratosphere.

  8. Entrance-channel Mass-asymmetry Dependence of Compound-nucleus Formation Time in Light Heavy-ion Reactions

    Szanto de Toledo, A; Beck, C; Thoennessen, M


    The entrance-channel mass-asymmetry dependence of the compound nucleus formation time in light heavy-ion reactions has been investigated within the framework of semiclassical dissipative collision models. the model calculations have been succesfully applied to the formation of the $^{38}$Ar compound nucleus as populated via the $^{9}$Be+$^{29}$Si, $^{11}$B+$^{27}$Al, $^{12}$C+$^{26}$Mg and $^{19}$F+$^{19}$F entrance channels. The shape evolution of several other light composite systems appears to be consistent with the so-called "Fusion Inhibition Factor" which has been experimentally observed. As found previously in more massive systems for the fusion-evaporation process, the entrance-channel mass-asymmetry degree of freedom appears to determine the competition between the different mechanisms as well as the time scales involved.

  9. Description of Four-Body Breakup Reaction with the Method of Continuum-Discretized Coupled-Channels

    Egami, Tomoaki; Ogata, Kazuyuki; Yahiro, Masanobu


    We present a method for smoothing discrete breakup $S$-matrix elements calculated by the method of continuum-discretized coupled-channels (CDCC). This smoothing method makes it possible to apply CDCC to four-body breakup reactions. The reliability of the smoothing method is confirmed for two cases, $^{58}$Ni($d$, $p n$) at 80 MeV and the $E1$ transition of $^6$He. We apply CDCC with the smoothing method to $^6$He breakup reaction at 22.5 MeV. Multi-step breakup processes are found to be important.

  10. Temperature dependent product yields for the spin forbidden singlet channel of the C(3P) + C2H2 reaction

    Hickson, Kevin M.; Loison, Jean-Christophe; Wakelam, Valentine


    The atomic hydrogen formation channels of the C + C2H2 reaction have been investigated using a continuous supersonic flow reactor over the 52-296 K temperature range. H-atoms were detected directly at 121.567 nm by vacuum ultraviolet laser induced fluorescence. Absolute H-atom yields were determined by comparison with the H-atom signal generated by the C + C2H4 reaction. The product yields agree with earlier crossed beam experiments employing universal detection methods. Incorporating these branching ratios in a gas-grain model of dense interstellar clouds increases the c-C3H abundance. This reaction is a minor source of C3-containing molecules in the present simulations.

  11. Temperature Dependent Product Yields for the Spin Forbidden Singlet Channel of the C(3P) + C2H2 Reaction

    Hickson, Kevin M; Wakelam, Valentine


    The atomic hydrogen formation channels of the C + C2H2 reaction have been investigated using a continuous supersonic flow reactor over the 52 K 296 K temperature range. H-atoms were detected directly at 121.567 nm by vacuum ultraviolet laser induced fluorescence. Absolute H-atom yields were determined by comparison with the H-atom signal generated by the C + C2H4 reaction. The product yields agree with earlier crossed beam experiments employing universal detection methods. Incorporating these branching ratios in a gas-grain model of dense interstellar clouds increases the cC3H abundance. This reaction is a minor source of C3 containing molecules in the present simulations.

  12. [Development of novel synthetic organic reactions: synthesis of antitumor natural products and leading compounds for new pharmaceuticals].

    Kita, Yasuyuki


    Biologically active natural products with unique, highly complex molecular skeletons have been used as leading compounds for raw materials of new drugs. Due to the limitations of natural supply, highly efficient, large-scale syntheses and molecular design have been sought in drug discovery. For this purpose, we have focused on a synthetic strategy effective in developing novel reactions and reagents and found several useful regio- and stereospecific reactions, contributing to the synthesis of otherwise unattainable target molecules. The application of these reactions for the total synthesis of three types of potent cytotoxic natural products for the first time is described in this paper. The basic concept is first described. Then the total synthesis of anthracyclines, fredericamycin A, and discorhabdins is reported. Novel reactions using hypervalent iodine reagents under environmentally benign conditions are also described. The future prospects for this method are discussed.

  13. 3-lead acquisition using single channel ECG device developed on AD8232 analog front end for wireless ECG application

    Agung, Mochammad Anugrah; Basari


    Electrocardiogram (ECG) devices measure electrical activity of the heart muscle to determine heart conditions. ECG signal quality is the key factor in determining the diseases of the heart. This paper presents the design of 3-lead acquistion on single channel wireless ECG device developed on AD8232 chip platform using microcontroller. To make the system different from others, monopole antenna 2.4 GHz is used in order to send and receive ECG signal. The results show that the system still can receive ECG signal up to 15 meters by line of sight (LOS) condition. The shape of ECG signals is precisely similar with the expected signal, although some delays occur between two consecutive pulses. For further step, the system will be applied with on-body antenna in order to investigate body to body communication that will give variation in connectivity from the others.


    Katarzyna Malinowska


    Full Text Available The effect of lead ions of the concentrations within the range of 15–1000 mg∙dm-3 on the physiological reaction of common osier var. Jorr was examined. The content of assimilation pigments, the rate the CO2 assimilation, transpiration, the indices of relative water content and the deficit of water saturation and the content of lead in the nutrient solution. The studied physiological parameters in common osier var. Jorr were differentiated by the rate of lead ions in the nutrient solution. The Jorr variety of common osier was characterised by good values of the determined physiological parameters under stressful conditions at a large accumulation of lead. This suggests that it shows quite a high tolerance to the stress caused by contamination of the subsoil with lead.

  15. Fission fragments mass distributions of nuclei populated by the multinucleon transfer channels of the 18O + 232Th reaction

    Léguillon, R.; Nishio, K.; Hirose, K.; Makii, H.; Nishinaka, I.; Orlandi, R.; Tsukada, K.; Smallcombe, J.; Chiba, S.; Aritomo, Y.; Ohtsuki, T.; Tatsuzawa, R.; Takaki, N.; Tamura, N.; Goto, S.; Tsekhanovich, I.; Petrache, C. M.; Andreyev, A. N.


    It is shown that the multinucleon transfer reactions is a powerful tool to study fission of exotic neutron-rich actinide nuclei, which cannot be accessed by particle-capture or heavy-ion fusion reactions. In this work, multinucleon transfer channels of the 18O + 232Th reaction are used to study fission of fourteen nuclei 231,232,233,234Th, 232,233,234,235,236Pa, and 234,235,236,237,238U. Identification of fissioning nuclei and of their excitation energy is performed on an event-by-event basis, through the measurement of outgoing ejectile particle in coincidence with fission fragments. Fission fragment mass distributions are measured for each transfer channel, in selected bins of excitation energy. In particular, the mass distributions of 231,234Th and 234,235,236Pa are measured for the first time. Predominantly asymmetric fission is observed at low excitation energies for all studied cases, with a gradual increase of the symmetric mode towards higher excitation energy. The experimental distributions are found to be in general agreement with predictions of the fluctuation-dissipation model.

  16. Fission fragments mass distributions of nuclei populated by the multinucleon transfer channels of the 18O+232Th reaction

    R. Léguillon


    Full Text Available It is shown that the multinucleon transfer reactions is a powerful tool to study fission of exotic neutron-rich actinide nuclei, which cannot be accessed by particle-capture or heavy-ion fusion reactions. In this work, multinucleon transfer channels of the 18O+232Th reaction are used to study fission of fourteen nuclei 231,232,233,234Th, 232,233,234,235,236Pa, and 234,235,236,237,238U. Identification of fissioning nuclei and of their excitation energy is performed on an event-by-event basis, through the measurement of outgoing ejectile particle in coincidence with fission fragments. Fission fragment mass distributions are measured for each transfer channel, in selected bins of excitation energy. In particular, the mass distributions of 231,234Th and 234,235,236Pa are measured for the first time. Predominantly asymmetric fission is observed at low excitation energies for all studied cases, with a gradual increase of the symmetric mode towards higher excitation energy. The experimental distributions are found to be in general agreement with predictions of the fluctuation–dissipation model.

  17. A Study of all reaction channels in deuteron-deuteron scattering at 65 MeV/nucleon

    Ramazani-Moghaddam-Arani, Ahmad [Kernfysisch Versneller Instituut, University of Groningen, Groningen (Netherlands); Department of Physics, Faculty of Science, University of Kashan, Kashan (Iran)


    Few-nucleon systems can be used as fundamental laboratories for studying the details of the nuclear force effects. We performed a series of deuteron-deuteron scattering experiments at intermediate energies. The experiments exploited BINA and BBS experimental setups and polarized deuteron beams with kinetic energies of 65 and 90 MeV/nucleon. These experiments aim to measure differential cross sections, vector and tensor analyzing powers of all available reaction channels in deuteron-deuteron scattering. With these data we will provide a systematic database, which will be used to test present theoretical approximations and upcoming ab-initio calculations in four-nucleon system. The analysis procedure along with the latest results of the elastic and three-body break-up channels will be presented.

  18. Four- and Sixfold Tandem-Domino Reactions Leading to Dimeric Tetrasubstituted Alkenes Suitable as Molecular Switches.

    Tietze, Lutz F; Waldecker, Bernd; Ganapathy, Dhandapani; Eichhorst, Christoph; Lenzer, Thomas; Oum, Kawon; Reichmann, Sven O; Stalke, Dietmar


    A highly efficient palladium-catalyzed fourfold tandem-domino reaction consisting of two carbopalladation and two C-H-activation steps was developed for the synthesis of two types of tetrasubstituted alkenes 3 and 6 with intrinsic helical chirality starting from substrates 1 and 4, respectively. A sixfold tandem-domino reaction was also developed by including a Sonogashira reaction. 20 compounds with different substitution patterns were prepared with yields of up to 97 %. Structure elucidation by X-ray crystallography confirmed helical chirality of the two alkene moieties. Photophysical investigations of some of the compounds showed pronounced switching properties through light-controlled changes of their stereochemical configuration. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. O/S-1/ interactions - The product channels. [collisional electron quenching and chemical reaction pathway frequencies

    Slanger, T. G.; Black, G.


    The first measurements are reported of the reaction pathways for the interaction between oxygen atoms in the 4.19 eV S-1 state, and four molecules, N2O, CO2, H2O, and NO. Distinction is made between three possible paths - quenching to O(D-1), quenching to O(P-3), and chemical reaction. With N2O, the most reasonable interpretation of the data indicates that there no reaction, in sharp contrast with the interaction between O(D-1) and N2O, which proceeds entirely by reaction. Similarly, there is no reaction with CO2. With H2O, the reactive pathway is the dominant one, although electronic quenching is not negligible. With NO, O(D-1) is the preferred product.

  20. Effects of in vitro and in vivo lead exposure on voltage-dependent calcium channels in central neurons of Lymnaea stagnalis.

    Audesirk, G


    Currents through calcium channels of members of an identified cluster of neurons (B cells) in the pond snail Lymnaea stagnalis were studied under voltage clamp. The normal physiological saline was modified to maximize the visibility of voltage-dependent calcium currents and minimize contamination by other currents. Barium was used as the charge carrier for the calcium channels. Depolarizing voltage steps induce an inward current, the magnitude of which varies with the barium concentration. In brains taken from animals not exposed in vivo to lead, in vitro addition of lead acetate to the recording medium (0.25 to 14 microM) inhibits the barium current by 59 +/- 14% (mean +/- s.d.), in a manner that is independent of the lead concentration. The magnitude of the residual current still varies with the barium concentration. The voltage dependence of the current appears to be unaffected by lead. In contrast to some other calcium-channel blockers, such as cobalt, the inhibition of barium currents by in vitro lead exposure is irreversible, at least in short-term experiments. Contrary to expectations based on these in vitro results, barium currents in B cells of animals exposed to 5 microM lead for 6 to 12 weeks in vivo were approximately twice as large as barium currents in B cells from unexposed controls, when both were recorded in lead-free saline. It is possible that chronic in vivo lead exposure causes an increase in the number of calcium channels in these neurons.

  1. Proton-induced cross-sections of nuclear reactions on lead up to 37 MeV

    Ditrói, F; Takács, S; Hermanne, A


    Excitation function of proton induced nuclear reactions on lead for production of $^{206,205,204,203,202,201g}$Bi, $^{203cum,202m,201cum}$Pb and $^{202cum,201cum,200cum,199cum}$Tl radionuclides were measured up to 36 MeV by using activation method, stacked foil irradiation technique and $\\gamma$-ray spectrometry. The new experimental data were compared with the few earlier experimental results and with the predictions of the EMPIRE3.1, ALICE-IPPE (MENDL2p) and TALYS (TENDL-2012) theoretical reaction codes.

  2. Effect of entrance channel parameters on the fusion of two heavy ions: Excitation functions of reaction products in 16O+66Zn and 37Cl + 45Sc reactions

    Suparne Sodaye; B S Tomar; A Goswami


    Excitation functions of reaction products formed in 16O+66Zn and 37Cl + 45Sc systems, leading to the same compound nucleus, 82Sr, were measured using recoilcatcher technique and off-line -ray spectrometry. The contribution of non-compound processes like transfer and incomplete fusion (ICF) reactions to the cross-sections of different evaporation residues were delineated by comparing the experimental data with the predictions of Monte Carlo simulation code PACE2. The results show that non-compound processes become a significant fraction of the total reaction cross-section in 16O+66Zn systems in the beam energy range studied, while 37Cl + 45Sc gives mainly compound nucleus products. The mass asymmetry dependence of the fusion and non-compound cross-sections have been analysed in terms of the static fusion model and sum rule model.

  3. Contribution of the t-channel N*(1535) exchange for the pp¯→ϕϕ reaction

    Shi, Jun; Dai, Jian-Ping; Zou, Bing-Song


    Since the N*(1535) resonance was found to have large coupling to the strangeness due to its possible large ss¯ component, we investigate the possible contribution of the t-channel N*(1535) exchange for the pp¯→ϕϕ reaction. Our calculation indicates that the new mechanism may give significant contribution for the energies above 2.25 GeV and may be an important source for evading the Okubo-Zweig-Iizuka rule in the ϕ production from NN¯ annihilation.

  4. Contribution of the t-channel $N^*(1535)$ exchange for the $p\\bar p \\to \\phi\\phi$ reaction

    Shi, Jun; Zou, Bing-Song


    Since the $N^*(1535)$ resonance was found to have large coupling to the strangeness due to its possible large $s\\bar s$ component, we investigate the possible contribution of the t-channel $N^*(1535)$ exchange for the $p\\bar p \\to \\phi\\phi$ reaction. Our calculation indicates that the new mechanism gives very significant contribution for the energies above 2.25 GeV and may be an important source for evading the Okubo-Zweig-Iizuka rule in the $\\phi$ production from $N \\bar{N}$ annihilation.

  5. Adiabatic Channel Capture Theory Applied to Cold Atom-Molecule Reactions: Li + CaH -> LiH + Ca at 1 K

    Tscherbul, Timur V


    We use quantum and classical adiabatic capture theories to study the chemical reaction Li + CaH -> LiH + Ca. Using a recently developed ab initio potential energy surface, which provides an accurate representation of long-range interactions in the entrance reaction channel, we calculate the adiabatic channel potentials by diagonalizing the atom-molecule Hamiltonian as a function of the atom-molecule separation. The resulting adiabatic channel potentials are used to calculate both the classical and quantum capture probabilities as a function of collision energy, as well as the temperature dependencies of the partial and total reaction rates. The calculated reaction rate agrees well with the measured value at 1 K [V. Singh et al., Phys. Rev. Lett. 108, 203201 (2012)], suggesting that the title reaction proceeds without an activation barrier. The calculated classical adiabatic capture rate agrees well with the quantum result in the multiple partial wave regime of relevance to the experiment. Significant differen...

  6. On the top of ARB N/L type Ca channel blocker leads to less elevation of aldosterone

    Konoshita, Tadashi; Kaeriyama, Saori; Urabe, Machi; Nakaya, Takahiro; Yamada, Mika; Ichikawa, Mai; Yamamoto, Katsushi; Sato, Satsuki; Imagawa, Michiko; Fujii, Miki; Makino, Yasukazu; Zenimaru, Yasuo; Wakahara, Shigeyuki; Suzuki, Jinya; Ishizuka, Tamotsu; Nakamura, Hiroyuki


    The activation of the renin–angiotensin system (RAS) is one of the unfavourable characteristics of calcium channel blocker (CCB). N type calcium channel is thought to be involved in renin gene transcription and adrenal aldosterone release. Accordingly, N/L type CCB has a possibility of less elevation of plasma aldosterone concentrations (PAC) among CCBs. In a monotherapy study, we had already demonstrated that N/L type CCB leads to less activation of the RAS compared with L type CCB. The objective of this study is to substantiate the hypothesis that at the condition of additive administration on the top of an angiotensin receptor blocker (ARB), still N/L type CCB leads to less elevation of PAC compared with L type one. Subjects were 60 hypertensives administered with valsartan. As an open label study, amlodipine (L type) or cilnidipine (N/L type) were administered on the top of valsartan (ARB) in a cross-over manner. Results were as follows (valsartan+amlodipine compared with valsartan+cilnidipine): systolic blood pressure (SBP)/diastolic blood pressure (DBP) (mmHg): 132±10/76±10 compared with 131±10/77±9, P=0.95/0.48, plasma renin activity (PRA) (ng/ml·h): 2.41±2.67 compared with 2.00±1.50 P=0.20, PAC (pg/ml): 77.3±31.0 compared with 67.4±24.8, P<0.05, urinary albumin excretion (UAE) (mg/gCr): 105.9±216.1 compared with 73.9±122.2, P<0.05. Thus, PAC at cilnidipine was significantly lower than those at amlodipine in spite of the comparable BP reductions. Besides, UAE was significantly lower at cilnidipine. In conclusion, on the top of the ARB, it is suggested that cilnidipine administration might lead to less elevation of PAC and reduction in UAE compared with amlodipine. PMID:27515419

  7. Free Convection Heat and Mass Transfer MHD Flow in a Vertical Channel in the Presence of Chemical Reaction

    R. N. Barik


    Full Text Available An analysis is made to study the effects of diffusion-thermo and chemical reaction on fully developed laminar MHD flow of electrically conducting viscous incompressible fluid in a vertical channel formed by two vertical parallel plates was taken into consideration with uniform temperature and concentration. The analytical solution by Laplace transform technique of partial differential equations is used to obtain the expressions for the velocity, temperature and concentration. It is interesting to note that during the course of computation, the transient solution at large time coincides with steady state solution derived separately and the diffusion-thermo effect creates an anomalous situation in temperature and velocity profiles for small Prandtl numbers. The study is restricted to only destructive reaction and non-conducting case cannot be derived as a particular case still it is quite interesting and more realistic than the earlier one.

  8. Lattice location of O18 in ion implanted Fe crystals by Rutherford backscattering spectrometry, channeling and nuclear reaction analysis

    Vairavel, Mathayan; Sundaravel, Balakrishnan; Panigrahi, Binaykumar


    There are contradictory theoretical predictions of lattice location of oxygen interstitial atom at tetrahedral and octahedral interstices in bcc Fe. For validating these predictions, 300 keV O18 ions with fluence of 5 × 1015 ions/cm2 are implanted into bcc Fe single crystals at room temperature and annealed at 400 °C. The Rutherford backscattering spectrometry (RBS) and nuclear reaction analysis (NRA)/channeling measurements are carried out with 850 keV protons. The lattice location of implanted O18 is analysed using the α-particles yield from O18(p,α)N15 nuclear reaction. The tilt angular scans of α-particle yield along and axial directions are performed at room temperature. Lattice location of O18 is found to be at tetrahedral interstitial site by comparing the experimental scan with simulated scans using FLUX7 software.

  9. Rapid Synthesis of Lead Oxide Nanorods by One-step Solid-state Chemical Reaction at Room Temperature

    CAO, Ya-Li(曹亚丽); JIA, Dian-Zeng(贾殿赠); LIU, Lang(刘浪); LUO, Jian-Min(骆建敏)


    A simple and facile method was reported to synthesize lead oxide nanorods. Nanorods of lead oxide were obtained directly from grinding solid metal salt and sodium hydroxide in agate mortar with the assistance of a suitable nonionic surfactant in only one step, which is different from the result of hydroxide in solution. The product has been characterized by XRD, TEM and SEM. The formation mechanism of rod-like morphology is discussed and the surfactant plays an important soft-template role in modifying the interface of solid-state reaction and according process of rod-formation.

  10. Dissipative effects in fission investigated with proton-on-lead reactions

    Rodríguez-Sánchez J. L.


    Full Text Available The complete kinematic measurement of the two fission fragments permitted us to investigate dissipative effects at large deformations, between the saddle-point and the corresponding scission configurations. Up to now, this kind of study has only been performed with fusionfission reactions using a limited number of observables, such as the mass distribution of the fission fragments or the neutron multiplicities. However, the large angular momenta gained by the compound nucleus could affect the conclusions drawn from such experiments. In this work, the use of spallation reactions, where the fissioning systems are produced with low angular momentum, small deformations and high excitation energies, favors the study of dissipation, and allowed us to define new observables, such as postscission neutron multiplicities and the neutron excess of the final fission fragments as a function of the atomic number of the fissioning system. These new observables are used to investigate the dissipation at large deformations.

  11. Zinc catalyzed Guanylation reaction of Amines with Carbodiimides/ Isocyanate leading to Guanidines/Urea derivatives formation



    We report the highly chemo-selective catalytic addition of N–H bonds from various aromaticamines to carbodiimides and isocyanates using (Ar-BIAO)ZnCl2 complexes [Ar-BIAO = N-(aryl)iminoacenapthenone,Ar = 2,6-$Me_{2}C_{6}H_{3}$ (1), 2,4,6 $Me_{3}C_{6}H_{2}$ (2), $2,6-^{i}$ $Pr_{2}C_{6}_H{3} (3)] as the pre-catalyst to prepareguanidine and urea derivatives in 55-90% yield. The complex 3 showed higher catalytic activity than analogouscomplexes 1 and 2 under similar reaction conditions. The catalytic guanylation of N–H bonds with heterocumulenesdisplays a broad substrate scope. The amines having electron donating groups underwent higher conversionthan the amines having electron withdrawing groups to afford corresponding guanidine or urea derivatives.A possible mechanism involving penta-coordinated zinc transition state for the catalytic reaction is presented.

  12. Adverse drug reactions leading to urgent hospital admission in an elderly population: prevalence and main features.

    Pedrós, Consuelo; Formiga, Francesc; Corbella, Xavier; Arnau, Josep Maria


    To assess the prevalence of urgent hospitalization due to adverse drug reactions (ADRs) in patients aged ≥ 65 years, to compare the in-hospital mortality rates between patients admitted for ADRs and those admitted for other causes, and to describe the ADRs, the used and suspected drugs, and the drug-reaction associations. A cross-sectional study was conducted by using the institutional database of the Pharmacovigilance Programme of Bellvitge University Hospital, a 750-bed tertiary care hospital, with information corresponding to a 7-year period. ADR-related admissions of patients aged ≥ 65 years prospectively identified through a systematic daily review of all admission diagnosis were reviewed. ADRs were suspected to be the main reason for urgent admission in 1976 out of 60,263 patients aged ≥ 65 years (prevalence of ADR-related hospitalization 3.3 % [95 % CI 3.1-3.4 %]). The crude in-hospital mortality rate was 10.2 % in patients with ADR-related admission and 9 % in patients admitted for other causes (p = 0.077). Most patients (86 %) were exposed to polypharmacy, and a drug-drug interaction was suspected in 49 % of cases. The most frequent drug-reaction associations were acute renal failure related to renin-angiotensin system inhibitors, gastrointestinal bleeding caused by antithrombotics and/or non-steroidal anti-inflammatories, and intracranial bleeding induced by vitamin K antagonists. One out of every 30 urgent admissions of patients aged ≥ 65 years is ADR-related. These ADRs can be as serious and life-threatening as any other acute pathology that merits urgent hospital admission. Most cases involve patients exposed to polypharmacy and result from well-known reactions of a few commonly used drugs.

  13. Electrocatalysis of anodic oxygen-transfer reactions at modified lead dioxide electrodes

    Hsiao, Yun-Lin.


    The electrocatalytic activities were compared for pure and chloride-doped beta-PbO{sub 2} (Cl-PbO{sub 2}) films on gold and platinum substrates. Rate constants were increased significantly for oxidations of Mn{sup 2+}, toluene, benzyl alcohol, dimethylsulphoxide (DMSO) and benzaldehyde in acidic media by the incorporation of Cl{sup {minus}} into the oxide films. These reactions are concluded to occur by the electrocatalytic transfer of oxygen from H{sub 2}O to the reaction products. Results of x-ray diffraction studies indicate the Cl-PbO{sub 2} film continues to have the slightly distorted rutile structure of pure beta-PbO{sub 2}. The observed electrocatalytic phenomena are concluded to be the beneficial consequence of surface defects generated when Cl{sup {minus}} serves for charge compensation within the surface matrix and, thereby, increases the number of surface sites capable of adsorbing hydroxyl radicals which are transferred in the electrocatalytic O-transfer reactions. 91 refs., 44 figs., 10 tabs.

  14. [Influence of Reaction Time on Titanate Nanomaterials and Its Adsorptioi Capability for Lead in Aqueous Solutions].

    Fan, Gong-duan; Chen, Li-ru; Lin, Ru-jing; Lin, Qian; Su, Zhao-yue; Lin, Xiu-yong


    Titanate nanomaterials (TNs) were synthesized via a simple hydrothermal method using TiO2 (ST-01) and NaOH as the raw materials, and presented different morphologies by adjusting the reaction time. The physico-chemical properties of the as-prepared TNs, such as morphology, structure, surface area, and chemical composition were characterized by XRD, SEM and BET. The adsorption capability and rules of Pb(II) in aqueous solutions were tested in the static system. The results showed that the TNs prepared with 12-72 h reaction time were pure monoclinic phase titanate and their specific surface areas were in the range from 243.05 m2 x g(-1) to 286.20 m2 x g(-1). TNs with reaction time between 12-36 h mainly showed sheet structure, and those with reaction time higher than 48 h showed linear structure. The adsorption capacity of Pb(II) by TNs-12, TNs-24, TNs-36, TNs-48, TNs-60 and TNs-72 was 479.40, 504.12, 482.00, 388.10, 364.60 and 399.00 mg x g(-1), respectively. The sheet TNs had a better adsorption capacity than the linear TNs. TNs-24 had the highest adsorbing capacity. The adsorption kinetics of Pb(II) by TNs-24 followed the pseudo-second-order model, and the equilibrium data was best fitted with the Langmuir isotherm model. The equilibrium adsorption time of TNs-24 was 120 min, and the adsorption was an exothermic process, with a high adsorption capacity at low temperature or room temperature; the optimal adsorption pH was 5.0. When pH was 1.0, the desorption rate of TNs-24 could reach 99.00%, and the removal efficiency of Pb(II) by regenerated TNs was still more than 97% after six times of usage. Therefore, TNs could efficiently remove Pb(II) in aqueous solutions, and the optimal reaction time should be controlled to 12-24 h. When Cd(II) or Ni(II) existed in the solution, the equilibrium adsorption capacity and removal rate of TNs-24 were decreased. The adsorption mechanism was mainly ion-exchanged between Pb(II) and H+/Na+ in TNs.

  15. Nonlinear predictive control for the concentrations profile regulation under unknown reaction disturbances in a fuel cell anode gas channel

    Luna, Julio; Ocampo-Martinez, Carlos; Serra, Maria


    In this work, a nonlinear model predictive control (NMPC) strategy is proposed to regulate the concentrations of the different gas species inside a Proton Exchange Membrane Fuel Cell (PEMFC) anode gas channel. The purpose of the regulation relies on the rejection of the unmeasurable perturbations that affect the system: the hydrogen reaction and water transport terms. The model of the anode channel is derived from the discretisation of the partial differential equations that define the nonlinear dynamics of the system, taking into account spatial variations along the channel. Forward and backward discretisations of the distributed model are employed to take advantage of the boundary conditions of the problem. A linear observer is designed and implemented to perform output-feedback control of the plant. This information is fed to the controller to regulate the states towards their desired values. Simulation results are presented to show the performance of the proposed control method over a given case study. Different cost functions are compared and the one with minimum state-regulation error is identified. Suitable dynamic responses are obtained facing the different considered disturbances.

  16. Interfacial Reaction of Sn-Ag-Cu Lead-Free Solder Alloy on Cu: A Review

    Liu Mei Lee; Ahmad Azmin Mohamad


    This paper reviews the function and importance of Sn-Ag-Cu solder alloys in electronics industry and the interfacial reaction of Sn-Ag-Cu/Cu solder joint at various solder forms and solder reflow conditions. The Sn-Ag-Cu solder alloys are examined in bulk and in thin film. It then examines the effect of soldering conditions to the formation of intermetallic compounds such as Cu substrate selection, structural phases, morphology evolution, the growth kinetics, temperature and time is also disc...

  17. FT-IR spectroscopic imaging of reactions in multiphase flow in microfluidic channels.

    Chan, K L Andrew; Kazarian, Sergei G


    Rapid, in situ, and label-free chemical analysis in microfluidic devices is highly desirable. FT-IR spectroscopic imaging has previously been shown to be a powerful tool to visualize the distribution of different chemicals in flows in a microfluidic device at near video rate imaging speed without tracers or dyes. This paper demonstrates the possibility of using this imaging technology to capture the chemical information of all reactants and products at different points in time and space in a two-phase system. Differences in the rates of chemical reactions in laminar flow and segmented flow systems are also compared. Neutralization of benzoic acid in decanol with disodium phosphate in water has been used as the model reaction. Quantitative information, such as concentration profiles of reactant and products, can be extracted from the imaging data. The same feed flow rate was used in both the laminar flow and segmented flow systems. The laminar flow pattern was achieved using a plain wide T-junction, whereas the segmented flow was achieved by introducing a narrowed section and a nozzle at the T-junction. The results show that the reaction rate is limited by diffusion and is much slower with the laminar flow pattern, whereas the reaction is completed more quickly in the segmented flow due to better mixing.

  18. Hyperon production in photonuclear reactions on protons and deuterons : The Kappa(0)Sigma(+) channel

    Lohner, H; Bacelar, J; Castelijns, R; Messchendorp, J; Shende, S; Maeda, K; Tamura, H; Nakamura, SN; Hashimoto, O


    With the combined setup of the Crystal Barrel and TAPS photonspectrometers at ELSA in Bonn we have studied photonuclear reactions on protons and deuterons. From the series of experiments on single and multiple neutral meson emission we concentrate here on the hyperon production off protons and deute

  19. Determination of Reactive Intermediates During Anodic Oxygen-transfer Reactions at Lead Dioxide

    AI Shi-yun; ZHANG Wen; GAO Meng-nan; GU Fen-lin; WANG Qing-jiang; JIN Li-tong


    The anodic discharge of water to produce adsorbed hydroxyl free radicals(*OH) is considered to be a prerequisite to anodic O-transfer reactions at a PbO2 electrode. In this work, a method was studied by means of high-performance liquid chromatography(HPLC) combined with electrochemical detection(ED) so as to investigate the production of hydroxyl free radicals(*OH) in the process of the anodic discharge of H2O at a PbO2 electrode. The voltammetric data obtained at the PbO2 electrode for the oxidation of salicylic acid to salicylate hydroxylation products(DHBAs) and the detection of DHBAs by means of HPLC-ED confirm the proposed mechanism.

  20. Next-to-leading-order corrections to capacity for a nondispersive nonlinear optical fiber channel in the intermediate power region

    Panarin, A. A.; Reznichenko, A. V.; Terekhov, I. S.


    We consider the optical fiber channel modeled by the nonlinear Schrödinger equation with zero dispersion and additive Gaussian noise. Using the Feynman path-integral approach for the model, we find corrections to conditional probability density function, output signal distribution, conditional and output signal entropies, and the channel capacity at large signal-to-noise ratio. We demonstrate that the correction to the channel capacity is positive for large signal power. Therefore, this correction increases the earlier calculated capacity for a nondispersive nonlinear optical fiber channel in the intermediate power region.

  1. Unsteady Bioconvection Squeezing Flow in a Horizontal Channel with Chemical Reaction and Magnetic Field Effects

    Qingkai Zhao


    Full Text Available The time-dependent mixed bioconvection flow of an electrically conducting fluid between two infinite parallel plates in the presence of a magnetic field and a first-order chemical reaction is investigated. The fully coupled nonlinear systems describing the total mass, momentum, thermal energy, mass diffusion, and microorganisms equations are reduced to a set of ordinary differential equations via a set of new similarity transformations. The detailed analysis illustrating the influences of various physical parameters such as the magnetic, squeezing, and chemical reaction parameters and the Schmidt and Prandtl numbers on the distributions of temperature and microorganisms as well as the skin friction and the Nusselt number is presented. The conclusion is drawn that the flow field, temperature, and chemical reaction profiles are significantly influenced by magnetic parameter, heat generation/absorption parameter, and chemical parameter. Some examples of potential applications of such bioconvection could be found in pharmaceutical industry, microfluidic devices, microbial enhanced oil recovery, modeling oil, and gas-bearing sedimentary basins.

  2. Sleep restriction may lead to disruption in physiological attention and reaction time

    Arbind Kumar Choudhary


    Full Text Available Sleepiness is the condition where for some reason fails to go into a sleep state and will have difficulty in remaining awake even while carrying out activities. Sleep restriction occurs when an individual fails to get enough sleep due to high work demands. The mechanism between sleep restriction and underlying brain physiology deficits is not well assumed. The objective of the present study was to investigate the mental attention (P300 and reaction time [visual (VRT and auditory (ART] among night watchmen, at subsequent; first (1st day, fourth (4th day and seventh (7th day of restricted sleep period. After exclusion and inclusion criteria, the study was performed among 50 watchmen (age=18–35 years (n=50 after providing written informed consent and divided into two group. Group I-(Normal sleep (n=28 working in day time and used to have normal sleep in night (≥8 h; Group II-(Restricted sleep (n=22 - working in night time and used to have less sleep in night (≤3 h. Statistical significance between the different groups was determined by the independent student ʻtʼ test and the significance level was fixed at p≤0.05. We observed that among all normal and restricted sleep watchmen there was not any significant variation in Karolinska Sleepiness Scale (KSS score, VRT and ART, along with latency and amplitude of P300 on 1st day of restricted sleep. However at subsequent on 4th day and 7th day of restricted sleep, there was significant increase in (KSSscore, and prolongation of VRT and ART as well as alteration in latency and amplitude of P300 wave in restricted sleep watchmen when compare to normal sleep watchmen. The present finding concludes that loss of sleep has major impact in dynamic change in mental attention and reaction time among watchmen employed in night shift. Professional regulations and work schedules should integrate sleep schedules before and during the work period as an essential dimension for their healthy life.

  3. Sleep restriction may lead to disruption in physiological attention and reaction time.

    Choudhary, Arbind Kumar; Kishanrao, Sadawarte Sahebrao; Dadarao Dhanvijay, Anup Kumar; Alam, Tanwir


    Sleepiness is the condition where for some reason fails to go into a sleep state and will have difficulty in remaining awake even while carrying out activities. Sleep restriction occurs when an individual fails to get enough sleep due to high work demands. The mechanism between sleep restriction and underlying brain physiology deficits is not well assumed. The objective of the present study was to investigate the mental attention (P300) and reaction time [visual (VRT) and auditory (ART)] among night watchmen, at subsequent; first (1st) day, fourth (4th) day and seventh (7th) day of restricted sleep period. After exclusion and inclusion criteria, the study was performed among 50 watchmen (age=18-35 years) (n=50) after providing written informed consent and divided into two group. Group I-(Normal sleep) (n=28) working in day time and used to have normal sleep in night (≥8 h); Group II-(Restricted sleep) (n=22) - working in night time and used to have less sleep in night (≤3 h). Statistical significance between the different groups was determined by the independent student 't' test and the significance level was fixed at p≤0.05. We observed that among all normal and restricted sleep watchmen there was not any significant variation in Karolinska Sleepiness Scale (KSS) score, VRT and ART, along with latency and amplitude of P300 on 1st day of restricted sleep. However at subsequent on 4th day and 7th day of restricted sleep, there was significant increase in (KSS)score, and prolongation of VRT and ART as well as alteration in latency and amplitude of P300 wave in restricted sleep watchmen when compare to normal sleep watchmen. The present finding concludes that loss of sleep has major impact in dynamic change in mental attention and reaction time among watchmen employed in night shift. Professional regulations and work schedules should integrate sleep schedules before and during the work period as an essential dimension for their healthy life.

  4. Continuum-discretized coupled-channels method for four-body breakup reactions

    Kamimura, M; Hiyama, E; Ogata, K; Iseri, Y; Yahiro, M


    Development of the method of CDCC (Continuum-Discretized Coupled-Channels) from the level of three-body CDCC to that of four-body CDCC is reviewed. Introduction of the pseudo-state method based on the Gaussian expansion method for discretizing the continuum states of two-body and three-body projectiles plays an essential role in the development. Furthermore, introduction of the complex-range Gaussian basis functions is important to improve the CDCC for nuclear breakup so as to accomplish that for Coulomb and nuclear breakup. A successful application of the four-body CDCC to $^6$He+$^{12}$C scattering at 18 and 229.8 MeV is reported.

  5. Effect of cadmium and lead on the membrane potential and photoelectric reaction of Nitellopsis obtusa cells.

    Kurtyka, Renata; Burdach, Zbigniew; Karcz, Waldemar


    The effects of Cd and Pb on membrane potential (E(m)) and photoelectric reaction of Nitellopsis obtusa cells were investigated. It was found that Cd and Pb at 1.0 mM caused a depolarization of the E(m), whereas both metals at lower concentrations changed the E(m) in a different way. Pb at 0.1 mM and 0.01 mM hyperpolarized the E(m), whereas Cd at the same concentrations depolarized and did not change the E(m), respectively. In the presence of 0.01 mM Pb, the light-induced hyperpolarization of the E(m) was by 18% higher as compared to the control, whereas at 1.0 mM Pb it was by 40% lower. Pb at 0.1 mM and Cd at 0.01 mM or 5 × 0.01 mM did not change the light-induced membrane hyperpolarization. However, in the presence of Cd at 0.1 mM and 1.0 mM this hyperpolarization was 2-fold lower or was completely abolished, respectively. These results suggest that at high Cd and Pb concentrations both depolarization of the E(m) and decrease of light-induced membrane hyperpolarization in Nitellopsis obtusa cells are probably due to inhibition of the plasma membrane H(+)-ATPase activity, whereas both metals at lower concentrations differ in mechanism of membrane potential changes.

  6. Novel Metal-organic Framework Compound Pb(C5H4NCOO)2 Showing One-dimensional Channel Defined as Four Leads and Four Nicotinic Acids

    XU Xiao-yu; ZHOU Rui-sha; SONG Jiang-feng; XU Ji-qing


    the zigzag chain by edge-sharing mode along(001) direction. Pb atom is connected by six nicotinic acid molecules, leading neutral 3D metal-organic framework with a channel defined by four Pb atoms and four nicotinic acid molecules.

  7. Charge carrier recombination channels in the low-temperature phase of organic-inorganic lead halide perovskite thin films

    Christian Wehrenfennig


    Full Text Available The optoelectronic properties of the mixed hybrid lead halide perovskite CH3NH3PbI3−xClx have been subject to numerous recent studies related to its extraordinary capabilities as an absorber material in thin film solar cells. While the greatest part of the current research concentrates on the behavior of the perovskite at room temperature, the observed influence of phonon-coupling and excitonic effects on charge carrier dynamics suggests that low-temperature phenomena can give valuable additional insights into the underlying physics. Here, we present a temperature-dependent study of optical absorption and photoluminescence (PL emission of vapor-deposited CH3NH3PbI3−xClx exploring the nature of recombination channels in the room- and the low-temperature phase of the material. On cooling, we identify an up-shift of the absorption onset by about 0.1 eV at about 100 K, which is likely to correspond to the known tetragonal-to-orthorhombic transition of the pure halide CH3NH3PbI3. With further decreasing temperature, a second PL emission peak emerges in addition to the peak from the room-temperature phase. The transition on heating is found to occur at about 140 K, i.e., revealing significant hysteresis in the system. While PL decay lifetimes are found to be independent of temperature above the transition, significantly accelerated recombination is observed in the low-temperature phase. Our data suggest that small inclusions of domains adopting the room-temperature phase are responsible for this behavior rather than a spontaneous increase in the intrinsic rate constants. These observations show that even sparse lower-energy sites can have a strong impact on material performance, acting as charge recombination centres that may detrimentally affect photovoltaic performance but that may also prove useful for optoelectronic applications such as lasing by enhancing population inversion.

  8. Partial strands synthesizing leads to inevitable aborting and complicated products in consecutive polymerase chain reactions (PCRs)


    Various abnormal phenomena have been observed during PCR so far. The present study performed a series of consecutive PCRs (including many rounds of re-amplification continuously) and found that the abortion of re-amplification was inevitable as long as a variety of complicated product appeared. The aborting stages varied, according to the lengths of targets. Longer targets reached the abortion earlier than the shorter ones, marked by appearance of the complex that was immobile in electropho-resis. Denatured gel-electrophoresis revealed that the complex was mainly made up of shorter or partially synthesized strands, together with small amounts of full-length ones. Able to be digested by S1 nuclease but unable by restriction endonucleases (REs), the complex was proved to consist of both single regions and double-helix regions that kept the complex stable thermodynamically. Simulations gave evidence that partial strands, even at lower concentration, could disturb re-amplification effec- tively and lead to the abortion of re-amplifications finally. It was pointed out that the partial strands formed chiefly via polymerase’s infidelity, and hence the solution to lighten the abnormality was also proposed.

  9. Partial strands synthesizing leads to inevitable aborting and complicated products in consecutive polymerase chain reactions (PCRs)

    LUO Rui; ZHANG DaMing


    Various abnormal phenomena have been observed during PCR so far. The present study performed a series of consecutive PCRs (including many rounds of re-amplification continuously) and found that the abortion of re-amplification was inevitable as long as a variety of complicated product appeared.The aborting stages varied, according to the lengths of targets. Longer targets reached the abortion earlier than the shorter ones, marked by appearance of the complex that was immobile in electrophoresis. Denatured gel-electrophoresis revealed that the complex was mainly made up of shorter or partially synthesized strands, together with small amounts of full-length ones. Able to be digested by S1 nuclease but unable by restriction endonucleases (REs), the complex was proved to consist of both single regions and double-helix regions that kept the complex stable thermodynamically. Simulations gave evidence that partial strands, even at lower concentration, could disturb re-amplification effectively and lead to the abortion of re-amplifications finally. It was pointed out that the partial strands formed chiefly via polymerase's infidelity, and hence the solution to lighten the abnormality was also proposed.

  10. The opening of maitotoxin-sensitive calcium channels induces the acrosome reaction in human spermatozoa: differences from the zona pellucida

    Julio C Chávez; Claudia L Trevi(n)o; Gerardo A de Blas; José L de la Vega-Beltrán; Takuya Nishigaki; Mayel Chirinos; María Elena González-González; Fernando Larrea; Alejandra Solís; Alberto Darszon


    The acrosome reaction(AR),an absolute requirement for spermatozoa and egg fusion,requires the influx of Ca2+into the spermatozoa through voltage-dependent Ca2+channels and store-operated channels.Maitotoxin(MTx),a Ca2+-mobilizing agent,has been shown to be a potent inducer of the mouse sperm AR,with a pharmacology similar to that of the zona pellucida(ZP),possibly suggesting a common pathway for both inducers.Using recombinant human ZP3(rhZP3),mouse ZP and two MTx channel blockers(U73122 and U73343),we investigated and compared the MTx-and ZP-induced ARs in human and mouse spermatozoa.Herein,we report that MTx induced AR and elevated intracellular Ca2+([Ca2+]1)in human spermatozoa,both of which were blocked by U73122 and U73343.These two compounds also inhibited the MTx-induced AR in mouse spermatozoa.In disagreement with our previous proposal,the AR triggered by rhZP3 or mouse ZP was not blocked by U73343,indicating that in human and mouse spermatozoa,the AR induction by the physiologicalligands or by MTx occurred through distinct pathways.U73122,but not U73343(inactive analogue),can block phospholipase C(PLC).Another PLC inhibitor,edelfosine,also blocked the rhZP3-and ZP-induced ARs.These findings confirmed the participation of a PLC-dependent signalling pathway in human and mouse zona protein-induced AR.Notably,edelfosine also inhibited the MTx-induced mouse sperm AR but not that of the human,suggesting that toxin-induced AR is PLC-dependent in mice and PLC-independent in humans.

  11. Fluorescence detection test by black printed circuit board based microfluidic channel for polymerase chain reaction.

    Hwang, Ji-Soo; Kim, Yu-Seop; Song, Hye-Jeong; Kim, Jong-Dae; Park, Chan-Young


    This paper proposes the optimal structure of a PCB-based micro PCR chip constructed on a PCB substrate using commercial adhesive tapes and plastic covers. The solder mask of the PCB substrate was coated black, and the area where the reaction chamber is attached was legend printed with white silk to minimize the noise during fluorescence detection. The performance of the PCR and fluorescence detection was compared using 6 types of reaction chambers, each made with different double-sided tapes. Three of the chambers were unsuccessful in completing the PCR. The performance of the other three chambers that successfully amplified DNA was compared using Taqman probe for Chlamydia Trachomatis DNA. The amplified product was illuminated diagonally with a blue LED to excite the product just before imaging, and the LED was turned off when the image was captured to prevent quenching of the probe. The images were taken 10 seconds prior to the last extension step for each cycle using a DSLR camera. The experiments were run as a quartet for each three chambers made with different double-sided tape. The results showed that there were significant difference between the three tapes.

  12. Reaction-based probe for hydrogen sulfite: dual-channel and good ratiometric response.

    Cheng, Xiaohong; He, Ping; Zhong, Zhicheng; Liang, Guijie


    We designed and synthesized a new series of intramolecular charge transfer (ICT) molecules (compounds T1, T2 and T3) by attaching various electron-donating thiophene groups to the triphenylamine backbone with aldehyde group as the electron acceptor. Based on the nucleophilic addition reaction between hydrogen sulfite and aldehyde, all compounds could act as ratiometric optical probe for hydrogen sulfite and displayed efficient chromogenic and fluorogenic signaling. Upon the addition of hydrogen sulfite anions, probe T3 displayed apparent fluorescent color changes from yellowish-green to blue, with a large emission wavelength shift (Δλ = 120 nm). T3 responded to hydrogen sulfite with high sensitivity and the detection limit was determined to be as low as 0.9 μM. At the same time, apparent changes in UV-vis spectra could also be observed. By virtue of the special nucleophilic addition reaction with aldehyde, T3 displayed high selectivity over other anions. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  13. Direct dynamics simulations of the product channels and atomistic mechanisms for the OH(-) + CH3I reaction. Comparison with experiment.

    Xie, Jing; Sun, Rui; Siebert, Matthew R; Otto, Rico; Wester, Roland; Hase, William L


    energy to relative translation, whereas transfer to product vibration is more important for the indirect reactions. For the proton-transfer reactions the velocity scattering angle distribution is peaked in the forward direction and in quite good agreement with experiment. However, for the SN2 reaction, the experimental scattering is isotropic in nature whereas forward scattering dominates the simulation distributions. The implication is that the simulations give too much stripping, which leads to forward scattering. The dynamics for the OH(-) + CH3I SN2 pathway are similar to those found previously for the F(-) + CH3I SN2 reaction.

  14. Effects of in vitro lead exposure on voltage-sensitive calcium channels differ among cell types in central neurons of Lymnaea stagnalis.

    Audesirk, G; Audesirk, T


    The effects of acute in vitro lead exposure on slowly inactivating voltage-sensitive calcium channels in central neurons of the freshwater pond snail Lymnaea stagnalis were studied under voltage clamp. Three physiologically distinct cell types were used: two subsets of the B cell cluster (Bpos and Bneg) and the pedal giant neuron (RPeD1). In Bpos neurons, 5 nM free Pb2+ irreversibly inhibited current flow through calcium channels by 38 +/- 10%. In Bneg neurons, 5 nM free Pb2+ slightly inhibited inward currents (12 +/- 6%) and may have shifted their voltage dependence to more depolarized voltages. The inhibition and voltage shift were irreversible. In RPeD1 neurons, Pb2+ caused a small, statistically insignificant inhibition of inward current (5 nM free Pb2+; 18 +/- 19%; 30 nM free Pb2+: 31 +/- 23%). The effects of Pb2+ were fully reversible. These data indicate that (1) voltage-sensitive calcium channels in Lymnaea neurons are inhibited by nanomolar concentrations of free Pb2+; (2) there are multiple types of calcium channels in Lymnaea neurons; and (3) the effects of in vitro lead exposure differ qualitatively among channel types.

  15. Combined Thermodynamic-Kinetic Analysis of the Interfacial Reactions between Ni Metallization and Various Lead-Free Solders

    Tomi Laurila


    Full Text Available In this paper we will demonstrate how a thermodynamic-kinetic method can be utilized to rationalize a wide range of interfacial phenomena between Sn-based lead-free solders and Ni metallizations. First, the effect of P on the interfacial reactions, and thus on the reliability, between Sn-based solders and electroless Ni/immersion Au (ENIG metallizations, will be discussed. Next, the effect of small amounts of Cu in Sn-based solders on the intermetallic compound (IMC, which forms first on top of Ni metallization, will be covered. With the help of thermodynamic arguments a so called critical Cu concentration for the formation of (Cu,Ni6Sn5 can be determined as a function of temperature. Then the important phenomenon of redeposition of (Au,NiSn4 layer on top of Ni3Sn4 IMC will be discussed in detail. The reasons leading to this behaviour will be rationalized with the help of thermodynamic information and an explanation of why this phenomenon does not occur when an appropriate amount of Cu is present in the soldering system will be given. Finally, interfacial reaction issues related to low temperature Sn-Zn and Sn-Bi based solders and Ni metallization will be discussed.

  16. Measurement of activation reaction rate distributions in a lead assembly bombarded with 500-MeV protons

    Takada, H; Sasa, T; Tsujimoto, K; Yasuda, H


    Reaction rate distributions of various activation detectors such as the /sup nat/Ni(n, x)/sup 58/Co, /sup 197/Au(n,2n)/sup 196/Au, and /sup 197/Au(n,4n)/sup 194/Au reactions were measured to study the production and the transport of spallation neutrons in a lead assembly bombarded with protons of 500 MeV. The measured data were analyzed with the nucleon-meson transport code NMTC/JAERI combined with the MCNP4A code using the nuclide production cross sections based on the JENDL Dosimetry File and those calculated with the ALICE-F code. It was found that the NMTC/JAERI-MCNP4A calculations agreed well with the experiments for the low-energy-threshold reaction of /sup nat/Ni(n, x)/sup 58/Co. With the increase of threshold energy, however, the calculation underestimated the experiments, especially above 20 MeV. The reason for the disagreement can be attributed to the underestimation of the neutron yield in the tens of mega-electron-volt regions by the NMTC/JAERI code. (32 refs).

  17. Channels of the corpus callosum. Evidence from simple reaction times to lateralized flashes in the normal and the split brain.

    Iacoboni, M; Zaidel, E


    We studied 75 normal subjects and three commissurotomized patients using unimanual simple reaction times to lateralized flashes as a behavioural estimate of interhemispheric transmission time. Three different versions of the paradigm were performed: (i) the basic task; (ii) a motor task, with an increased complexity of the motor response; and (iii) a visual task, with an increased complexity of the visual stimulus presentation. We tested two hypotheses. First, that the new versions of the simple reaction time task result in shifts in hemispheric specialization for processing motor output (indicated by a main effect of response hand) or visual input (indicated by a main effect of visual field) alone, without affecting callosal transmission. In that case normals and split brain patients would show no significant task by response hand by visual field interaction and no significant task by crossed-uncrossed difference interaction. Secondly, that the new versions of the task affect callosal transfer. In that case, normals, but not split brain patients, would show a significant task by response hand by visual field interaction and a significant task by crossed-uncrossed difference interaction. Results are consistent with the latter hypothesis, showing that the motor task significantly changed the response hand by visual field interaction and the crossed-uncrossed difference, but only in normal subjects, perhaps producing a switch in the callosal channel subserving the interhemispheric transfer.

  18. 碳纳米管管腔在催化反应中的应用%Application of carbon nanotube channels in catalytic reactions



    The research progress in modification effect of carbon nanotubes for catalytic reactions confined inside their channels was summarized. The application of space confinement effect,spatial concentration effect and electronic modulation effect of carbon nanotubes was especially introduced. Carbon nanotubes could not only tune the particle size of the catalysts by changing the channel diameter,but also provide spatial restriction on metal catalyst encapsulated in their channels,which hampered particles aggregation during the reaction,thus maintaining good catalytic activity and stability. The spatial concentration effect of carbon nanotubes channels influenced on diffusion behavior of reactants and products around active particles by means of shape selectivity of carbon nanotubes channels,selective adsorption and desorption, thus modulating catalytic performance and the selectivity to product. Deviation from planarity caused electron density to shift from the concave inner to the convex outer surface,leading to the electron potential difference between inside and outside of carbon nanotubes,and therefore the electron density of the catalysts inside and outside carbon nanotubes was modified. The catalytic activity and the selectivity to products could be improved effectively.%综述近年来碳纳米管管腔对催化反应性能调变作用的研究进展,重点介绍碳纳米管管腔空间限域效应、空间富集效应和电子调变效应在催化反应中的应用,碳纳米管管腔的空间限域效应能够调节催化剂粒子大小,在反应过程中限制粒子团聚,有效维持反应活性和稳定性。碳纳米管管腔的空间富集效应通过管腔择形、选择吸附及脱附等影响催化反应中反应物和产物分子在管腔内活性位周围的扩散行为,从而影响反应活性和目标产物选择性。石墨烯片卷曲形成碳纳米管的过程中,造成碳纳米管管腔内缺电子管腔外富电子的特殊电子结

  19. Allowance for the tunnel effect in the entrance channel of fusion-fission reactions

    Litnevsky, V. L.; Kosenko, G. I.; Ivanyuk, F. A.


    A two-stage model is developed in order to describe fusion-fission reactions. The process in the course of which colliding ions approach each other is simulated at the first stage, the deformations and relative orientations of the ions being taken into account. The first stage of the calculation is completed as soon as colliding nuclei touch each other. A continuous nuclear system (monosystem) is formed at this instant. The emerging distributions of the angular momenta of this system and of its potential and internal energies at the point of touching are used as input data that are necessary for triggering the second stage of the calculation. The evolution of collective coordinates that describe the shape of the monosystem is calculated at the second stage. The description of this evolution is terminated either at the instant of its fission or upon the release of a major part of its excess energy via particle and photon emission. In the latter case, the probability for the fission of the monosystem or a further decrease in its excitation energy becomes extremely small. The ion-collision process and the evolution of the monosystem formed after primary nuclei come into contact are simulated on the basis of stochastic Langevin equations. The quantities appearing in them (which include the potential energy and inertial and friction parameters) are determined with allowance for the shell structure of nuclei. The tunneling of colliding nuclei through the Coulomb barrier is taken into account, and the effect of this phenomenon on model predictions is studied.

  20. Activation of K{sup +} channels and Na{sup +}/K{sup +} ATPase prevents aortic endothelial dysfunction in 7-day lead-treated rats

    Fiorim, Jonaina, E-mail: [Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, ES (Brazil); Ribeiro Júnior, Rogério Faustino, E-mail: [Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, ES (Brazil); Azevedo, Bruna Fernades, E-mail: [Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, ES (Brazil); Simões, Maylla Ronacher, E-mail: [Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, ES (Brazil); Padilha, Alessandra Simão, E-mail: [Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, ES (Brazil); Stefanon, Ivanita, E-mail: [Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, ES (Brazil); Alonso, Maria Jesus, E-mail: [Departamento de Ciencias de la Salud III, Universidad Rey Juan Carlos, Alcorcón (Spain); Salaices, Mercedes, E-mail: [Departamento de Farmacología, Universidad Autónoma de Madrid, Instituto de Investigación Hospital Universitario La Paz (IdiPaz) (Spain); Vassallo, Dalton Valentim, E-mail: [Department of Physiological Sciences, Federal University of Espirito Santo, Vitoria, ES (Brazil)


    Seven day exposure to a low concentration of lead acetate increases nitric oxide bioavailability suggesting a putative role of K{sup +} channels affecting vascular reactivity. This could be an adaptive mechanism at the initial stages of toxicity from lead exposure due to oxidative stress. We evaluated whether lead alters the participation of K{sup +} channels and Na{sup +}/K{sup +}-ATPase (NKA) on vascular function. Wistar rats were treated with lead (1st dose 4 μg/100 g, subsequent doses 0.05 μg/100 g, im, 7 days) or vehicle. Lead treatment reduced the contractile response of aortic rings to phenylephrine (PHE) without changing the vasodilator response to acetylcholine (ACh) or sodium nitroprusside (SNP). Furthermore, this treatment increased basal O{sub 2}{sup −} production, and apocynin (0.3 μM), superoxide dismutase (150 U/mL) and catalase (1000 U/mL) reduced the response to PHE only in the treated group. Lead also increased aortic functional NKA activity evaluated by K{sup +}-induced relaxation curves. Ouabain (100 μM) plus L-NAME (100 μM), aminoguanidine (50 μM) or tetraethylammonium (TEA, 2 mM) reduced the K{sup +}-induced relaxation only in lead-treated rats. When aortic rings were precontracted with KCl (60 mM/L) or preincubated with TEA (2 mM), 4-aminopyridine (4-AP, 5 mM), iberiotoxin (IbTX, 30 nM), apamin (0.5 μM) or charybdotoxin (0.1 μM), the ACh-induced relaxation was more reduced in the lead-treated rats. Additionally, 4-AP and IbTX reduced the relaxation elicited by SNP more in the lead-treated rats. Results suggest that lead treatment promoted NKA and K{sup +} channels activation and these effects might contribute to the preservation of aortic endothelial function against oxidative stress. -- Highlights: ► Increased free radicals production ► Increased Na{sup +}/K{sup +} ATPase activity ► Promotes activation of the K{sup +} channels and reduced vascular reactivity ► These effects preserve endothelial function against oxidative

  1. Copper-catalyzed tandem reaction of 2-bromobenzyl bromides with 1,3-dicarbonyl compounds leading to 4H-chromenes

    Xin Ying Zhang; Liang Liang Fang; Nan Liu; Hua Yue Wu; Xue Sen Fan


    A Cu(I)-catalyzed one-pot tandem reaction of 2-bromobenzyl bromides with 1,3-dicarbonyl compounds leading to 4H-chromene derivatives has been developed.This new approach toward 4H-chromenes combines several reactions in one pot and builds molecular complexity from readily available starting materials.

  2. A double decarboxylation reaction of an oxazolidinone and carboxylic Acid: its application to the synthesis of a new opioid lead compound.

    Fujii, Hideaki; Imaide, Satomi; Watanabe, Akio; Yoza, Kenji; Nakajima, Mayumi; Nakao, Kaoru; Mochizuki, Hidenori; Sato, Noriko; Nemoto, Toru; Nagase, Hiroshi


    Treatment of oxazolidinone carboxylic acid 6 with potassium carbonate gave olefin 7 by a double decarboxylation reaction. The reaction was proposed to proceed via decarboxylation followed by E1cB-like mechanism. 15,16-Nornaltrexone derivative 17 prepared from double decarboxylation product 7 showed strong affinity for the mu opioid receptor, indicating it to be a new opioid lead compound.

  3. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.

    Xu, Haoxing; Delling, Markus; Li, Linyu; Dong, Xianping; Clapham, David E


    Transient receptor potential (TRP) genes of the mucolipin subfamily (TRPML1-3 and MCOLN1-3) are presumed to encode ion channel proteins of intracellular endosomes and lysosomes. Mutations in human TRPML1 (mucolipin 1/MCOLN1) result in mucolipidosis type IV, a severe inherited neurodegenerative disease associated with defective lysosomal biogenesis and trafficking. A mutation in mouse TRPML3 (A419P; TRPML3(Va)) results in the varitint-waddler (Va) phenotype. Va mice are deaf, exhibit circling behavior due to vestibular defects, and have variegated/dilute coat color as a result of pigmentation defects. Prior electrophysiological studies of presumed TRPML plasma membrane channels are contradictory and inconsistent with known TRP channel properties. Here, we report that the Va mutation produces a gain-of-function that allows TRPML1 and TRPML3 to be measured and identified as inwardly rectifying, proton-impermeant, Ca(2+)-permeant cation channels. TRPML3 is highly expressed in normal melanocytes. Melanocyte markers are lost in the Va mouse, suggesting that their variegated and hypopigmented fur is caused by severe alteration of melanocyte function or cell death. TRPML3(Va) expression in melanocyte cell lines results in high resting Ca(2+) levels, rounded, poorly adherent cells, and loss of membrane integrity. We conclude that the Va phenotype is caused by mutation-induced TRPML3 gain-of-function, resulting in cell death.

  4. Effect of trace elements on the interface reactions between two lead-free solders and copper or nickel substrates

    Soares D.


    Full Text Available Traditional Sn-Pb solder alloys are being replaced, because of environmental and health concerns about lead toxicity. Among some alternative alloy systems, the Sn-Zn and Sn-Cu base alloy systems have been studied and reveal promising properties. The reliability of a solder joint is affected by the solder/substrate interaction and the nature of the layers formed at the interface. The solder/substrate reactions, for Sn-Zn and Sn-Cu base solder alloys, were evaluated in what concerns the morphology and chemical composition of the interface layers. The effect of the addition of P, at low levels, on the chemical composition of the layers present at the interface was studied. The phases formed at the interface between the Cu or Ni substrate and a molten lead-free solder at 250ºC, were studied for different stage times and alloy compositions. The melting temperatures, of the studied alloys, were determined by Differential Scanning Calorimetry (DSC. Identification of equilibrium phases formed at the interface layer, and the evaluation of their chemical composition were performed by Scanning Electron Microscopy (SEM/EDS. Different interface characteristics were obtained, namely for the alloys containing Zn. The obtained IML layer thickness was compared, for both types of alloy systems.

  5. Photosynthesis light-independent reactions are sensitive biomarkers to monitor lead phytotoxicity in a Pb-tolerant Pisum sativum cultivar.

    Rodriguez, Eleazar; da Conceição Santos, Maria; Azevedo, Raquel; Correia, Carlos; Moutinho-Pereira, José; Ferreira de Oliveira, José Miguel Pimenta; Dias, Maria Celeste


    Lead (Pb) environmental contamination remains prevalent. Pisum sativum L. plants have been used in ecotoxicological studies, but some cultivars showed to tolerate and accumulate some levels of Pb, opening new perspectives to their use in phytoremediation approaches. However, the putative use of pea plants in phytoremediation requires reliable toxicity endpoints. Here, we evaluated the sensitivity of a large number of photosynthesis-related biomarkers in Pb-exposed pea plants. Plants (cv. "Corne de Bélier") were exposed to Pb concentrations up to 1,000 mg kg(-1) soil during 28 days. The photosynthetic potential biomarkers that were analyzed included pigments, chlorophyll (Chl) a fluorescence, gas exchange, ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) activity, and carbohydrates. Flow cytometry (FCM) was also used to assess the morpho-functional status of chloroplasts. Finally, Pb-induced nutrient disorders were also evaluated. Net CO2 assimilation rate (A) and RuBisCO activity decreased strongly in Pb-exposed plants. Plant dry mass (DM) accumulation, however, was only reduced in the higher Pb concentrations tested (500 and 1,000 mg kg(-1) soil). Pigment contents increased solely in plants exposed to the largest Pb concentration, and in addition, the parameters related to the light-dependent reactions of photosynthesis, Fv/Fm and ΦPSII, were not affected by Pb exposure. In contrast to this, carbohydrates showed an overall tendency to increase in Pb-exposed plants. The morphological status of chloroplasts was affected by Pb exposure, with a general trend of volume decrease and granularity increase. These results point the endpoints related to the light-independent reactions of photosynthesis as more sensitive predictors of Pb-toxicity than the light-dependent reactions ones. Among the endpoints related to the light-independent photosynthesis reactions, RuBisCO activity and A were found to be the most sensitive. We discuss here the advantages of using

  6. Establishing mass spectrum of $S=-1$ hyperon resonances via a dynamical coupled-channels analysis of $K^-p$ reactions

    Kamano, Hiroyuki


    We report our recent effort for the extraction of resonance parameters (complex pole mass and residues etc.) associated with Lambda* and Sigma* hyperons. This was accomplished via a comprehensive partial-wave analysis of the data for K^- p --> barK N, pi Sigma, pi Lambda, eta Lambda, K Xi reactions from the thresholds up to W=2.1 GeV within a dynamical coupled-channels approach. The results suggest a possible existence of new narrow J^P=3/2^+ \\Lambda resonance with pole mass 1671^{+2}_{-8} -i(5^{+11}_{-2}) MeV, located close to the eta Lambda threshold. This resonance is found to be responsible for reproducing the data for K^-p --> eta Lambda differential cross sections near the threshold, and thus the data seem favor its existence. The extracted poles for J^P=1/2^- Lambda resonances below the barK N threshold, including Lambda(1405), are also presented.

  7. Investigation of corrosion, water reaction, polonium evaporation and bismuth resource in liquid metal lead-bismuth technology

    Takano, Hideki; Takizuka, Takakazu [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Kitano, Teruaki [Mitsui Shipbuilding and Engineering Co. Ltd., Tokyo (Japan)


    Lead-bismuth is the first candidate material for liquid metal target find coolant of fueled blanket system in accelerator-driven system (ADS) studied at JAERI. Advantages of the lead-bismuth utilization are non-active material, very low capture cross section, low melting point of 125degC and high boiling point of 1670degC, and beside coolant void reactivity become negative. But problems are due to the high corrosivity to most of the structural materials and the corrosive data are scarcity. In this report, corrosivity, reaction with water, thermal-hydraulics, chemical toxicity etc. are studied by investigating some facilities utilized and researched really for lead or lead-bismuth. And, furthermore, polonium evaporation rate and bismuth resource are investigated. Main results obtained are as follows: (1) In a refinery, there are enough employment experience for liquid Pb-Bi in period of about 17 years and not corrosion for the thermal conductive materials (1Cr-0.5Mo steel) used under the condition of natural convection with temperature around 400degC. (2) In Russia, extensive experience in the use as Russian submarines and in R and D during about 50 years are available. And as a result, it will be able to lead approximately zero corrosion for Cr-Si materials by adjusting oxygen film with oxygen concentration control between 10{sup -7} to 10{sup -5}% mass. However, the corrosion data are not enough systematically collected involving them in radiation dose field. (3) In liquid-dropping experiment, it is shown that interaction between water and high temperature liquid Pb-Bi is reduced steeply with rising of atmosphere pressure. But, in order to design the second circuit removal model of ADS, the interaction should be evaluated by water continuous injection experiment. (4) Polonium forms PbPo in Pb-Bi, and the evaporation rate become less three factor than that of Po, and furthermore, the rate decreases in the atmosphere. The effects of Po on employee and environment

  8. Discriminative detection of low-abundance point mutations using a PCR/ligase detection reaction/capillary gel electrophoresis method and fluorescence dual-channel monitoring.

    Hamada, Mariko; Shimase, Koji; Tsukagoshi, Kazuhiko; Hashimoto, Masahiko


    We applied a facile LIF dual-channel monitoring system recently developed and reported by our group to the polymerase chain reaction/ligase detection reaction/CGE method for detecting low-abundance point mutations present in a wild-type sequence-dominated population. Mutation discrimination limits and signaling fidelity of the analytical system were evaluated using three mutant variations in codon 12 of the K-ras oncogene that have high diagnostic value for colorectal cancer. We demonstrated the high sensitivity of the present method by detecting rare mutations present among an excess of wild-type alleles (one mutation among ~100 normal sequences). This method also simultaneously interrogated the allelic compositions of the test samples with high specificity through spectral discrimination of the dye-tagged ligase detection reaction products using the dual-channel monitoring system. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability

    Speca, DJ; Ogata, G; Mandikian, D; Bishop, HI; Wiler, SW; Eum, K; Wenzel, HJ; Doisy, ET; Matt, L; Campi, KL; Golub, MS; Nerbonne, JM; Hell, JW; Trainor, BC; Sack, JT


    The Kv2.1 delayed rectifier potassium channel exhibits high-level expression in both principal and inhibitory neurons throughout the central nervous system, including prominent expression in hippocampal neurons. Studies of in vitro preparations suggest that Kv2.1 is a key yet conditional regulator of intrinsic neuronal excitability, mediated by changes in Kv2.1 expression, localization and function via activity-dependent regulation of Kv2.1 phosphorylation. Here we identify neurological and b...


    Bourgalais, Jérémy; Capron, Michael; Picard, Sébastien D. Le [Institut de Physique de Rennes, Astrophysique de Laboratoire, UMR CNRS 6251, Université de Rennes 1, Bât. 11C, Campus de Beaulieu, F-35042 Rennes Cedex (France); Kailasanathan, Ranjith Kumar Abhinavam; Goulay, Fabien [Department of Chemistry, West Virginia University, Morgantown, WV 26506 (United States); Osborn, David L. [Combustion Research Facility, Mail Stop 9055, Sandia National Laboratories, Livermore, CA 94551 (United States); Hickson, Kevin M.; Loison, Jean-Christophe [Université de Bordeaux, Institut des Sciences Moléculaires, UMR 5255, F-33400 Talence (France); Wakelam, Valentine, E-mail:, E-mail:, E-mail: [Univ. Bordeaux, LAB, UMR 5804, F-33270 Floirac (France)


    The product formation channels of ground state carbon atoms, C({sup 3}P), reacting with ammonia, NH{sub 3}, have been investigated using two complementary experiments and electronic structure calculations. Reaction products are detected in a gas flow tube experiment (330 K, 4 Torr) using tunable vacuum-ultraviolet (VUV) photoionization coupled with time of flight mass spectrometry. Temporal profiles of the species formed and photoionization spectra are used to identify primary products of the C + NH{sub 3} reaction. In addition, H-atom formation is monitored by VUV laser induced fluorescence (LIF) from room temperature to 50 K in a supersonic gas flow generated by the Laval nozzle technique. Electronic structure calculations are performed to derive intermediates, transition states, and complexes formed along the reaction coordinate. The combination of photoionization and LIF experiments supported by theoretical calculations indicate that in the temperature and pressure range investigated, the H + H{sub 2}CN production channel represents 100% of the product yield for this reaction. Kinetics measurements of the title reaction down to 50 K and the effect of the new rate constants on interstellar nitrogen hydride abundances using a model of dense interstellar clouds are reported in Paper II.

  11. Evaluation of potential reaction mechanisms leading to the formation of coniferyl alcohol α-linkages in lignin: a density functional theory study.

    Watts, Heath D; Mohamed, Mohamed Naseer Ali; Kubicki, James D


    Five potential reaction mechanisms, each leading to the formation of an α-O-4-linked coniferyl alcohol dimer, and one scheme leading to the formation of a recently proposed free-radical coniferyl alcohol trimer were assessed using density functional theory (DFT) calculations. These potential reaction mechanisms were evaluated using both the calculated Gibbs free energies, to predict the spontaneity of the constituent reactions, and the electron-density mapped Fukui function, to determine the most reactive sites of each intermediate species. The results indicate that each reaction in one of the six mechanisms is thermodynamically favorable to those in the other mechanisms; what is more, the Fukui function for each free radical intermediate corroborates with the thermochemical results for this mechanism. This mechanism proceeds via the formation of two distinct free-radical intermediates, which then react to produce the four α-O-4 stereoisomers.

  12. Vinyl azides derived from allenes: thermolysis leading to multisubstituted 1,4-pyrazines and Mn(III)-catalyzed photochemical reaction leading to pyrroles.

    Sajna, K V; Kumara Swamy, K C


    Thermolysis of phosphorus-based vinyl azides under solvent- and catalyst-free conditions furnished a new route for 1,4-pyrazines. A simple one-pot, Mn(III)-catalyzed photochemical route has been developed for multisubstituted pyrroles starting from allenes and 1,3-dicarbonyls via in situ-generated vinyl azides. The utility of new phosphorus-based pyrroles is also demonstrated in the Horner reaction. The structures of key products are unequivocally confirmed by X-ray crystallography.

  13. Temporal correlation between two channels EEG of bipolar lead in the head midline is associated with sleep-wake stages.

    Li, Yanjun; Tang, Xiaoying; Xu, Zhi; Liu, Weifeng; Li, Jing


    Whether the temporal correlation between inter-leads Electroencephalogram (EEG) that located on the boundary between left and right brain hemispheres is associated with sleep stages or not is still unknown. The purpose of this paper is to evaluate the role of correlation coefficients between EEG leads Fpz-Cz and Pz-Oz for automatic classification of sleep stages. A total number of 39 EEG recordings (about 20 h each) were selected from the expanded sleep database in European data format for temporal correlation analysis. Original waveform of EEG was decomposed into sub-bands δ (1-4 Hz), θ (4-8 Hz), α (8-13 Hz) and β (13-30 Hz). The correlation coefficient between original EEG leads Fpz-Cz and Pz-Oz within frequency band 0.5-30 Hz was defined as r(EEG) and was calculated every 30 s, while that between the two leads EEG in sub-bands δ, θ, α and β were defined as r(δ), r(θ), r(α) and r(β), respectively. Classification of wakefulness and sleep was processed by fixed threshold that derived from the probability density function of correlation coefficients. There was no correlation between EEG leads Fpz-Cz and Pz-Oz during wakefulness (|r| r > 0.1 for r(EEG) and r(δ)), while low correlation existed during sleep (r ≈ -0.4 for r(EEG), r(δ), r(θ), r(α) and r(β)). There were significant differences (analysis of variance, P sleep when in comparison with that during wakefulness, respectively. The accuracy for distinguishing states between wakefulness and sleep was 94.2, 93.4, 89.4, 85.2 and 91.4% in terms of r(EEG), r(δ), r(θ), r(α) and r(β), respectively. However, no correlation index between EEG leads Fpz-Cz and Pz-Oz could distinguish all five types of wakefulness, rapid eye movement (REM) sleep, N1 sleep, N2 sleep and N3 sleep. In conclusion, the temporal correlation between EEG bipolar leads Fpz-Cz and Pz-Oz are highly associated with sleep-wake stages. Moreover, high accuracy of sleep-wake classification could be achieved by the temporal correlation

  14. A two-step reaction scheme leading to singlet carbene species that can be detected under matrix conditions for the reaction of Zr(3F) with either CH3F or CH3CN.

    Torres, Ana E; Castro, Guadalupe; Pablo-Pedro, Ricardo; Colmenares, Fernando


    The results obtained from CASSCF-MRMP2 calculations are used to rationalize the singlet complexes detected under matrix-isolation conditions for the reactions of laser-ablated Zr((3)F) atoms with the CH3F and CH3CN molecules, without invoking intersystem crossings between electronic states with different multiplicities. The reaction Zr((3)F) + CH3 F evolves to the radical products ZrF· + ·CH3. This radical asymptote is degenerate to that emerging from the singlet channel of the reactants Zr((1)D) + CH3 F because they both exhibit the same electronic configuration in the metal fragment. Hence, the caged radicals obtained under cryogenic-matrix conditions can recombine through triplet and singlet paths. The recombination of the radical species along the low-multiplicity channel produces the inserted structures H3C-Zr-F and H2C=ZrHF experimentally detected. For the Zr((3)F) + CH3 CN reaction, a similar two-step reaction scheme involving the radical fragments ZrNC· + ·CH3 explains the presence of the singlet complexes H C-Zr-NC and H2 C=Zr(H)NC revealed in the IR-matrix spectra upon UV irradiation.

  15. Hydrogen-oxygen flame acceleration and transition to detonation in channels with no-slip walls for a detailed chemical reaction model.

    Ivanov, M F; Kiverin, A D; Liberman, M A


    The features of flame acceleration in channels with wall friction and the deflagration to detonation transition (DDT) are investigated theoretically and using high resolution numerical simulations of two-dimensional reactive Navier-Stokes equations, including the effects of viscosity, thermal conduction, molecular diffusion, and a detailed chemical reaction mechanism for hydrogen-oxygen gaseous mixture. It is shown that in a wide channel, from the beginning, the flame velocity increases exponentially for a short time and then flame acceleration decreases, ending up with the abrupt increase of the combustion wave velocity and the actual transition to detonation. In a thin channel with a width smaller than the critical value, the exponential increase of the flame velocity is not bounded and ends up with the transition to detonation. The transition to detonation occurs due to the pressure pulse, which is formed at the tip of the accelerating flame. The amplitude of the pressure pulse grows exponentially due to a positive feedback coupling between the pressure pulse and the heat released in the reaction. Finally, large amplitude pressure pulse steepens into a strong shock coupled with the reaction zone forming the overdriven detonation. The evolution from a temperature gradient to a detonation via the Zeldovich gradient mechanism and its applicability to the deflagration-to-detonation transition is investigated for combustible materials whose chemistry is governed by chain-branching kinetics. The results of the high resolution simulations are fully consistent with experimental observations of the flame acceleration and DDT.

  16. Comparison of diagnostic value using a small, single channel, P-wave centric sternal ECG monitoring patch with a standard 3-lead Holter system over 24 hours.

    Smith, Warren M; Riddell, Fiona; Madon, Morag; Gleva, Marye J


    To compare simultaneous recordings from an external patch system specifically designed to ensure better P-wave recordings and standard Holter monitor to determine diagnostic efficacy. Holter monitors are a mainstay of clinical practice, but are cumbersome to access and wear and P-wave signal quality is frequently inadequate. This study compared the diagnostic efficacy of the P-wave centric electrocardiogram (ECG) patch (Carnation Ambulatory Monitor) to standard 3-channel (leads V1, II, and V5) Holter monitor (Northeast Monitoring, Maynard, MA). Patients were referred to a hospital Holter clinic for standard clinical indications. Each patient wore both devices simultaneously and served as their own control. Holter and Patch reports were read in a blinded fashion by experienced electrophysiologists unaware of the findings in the other corresponding ECG recording. All patients, technicians, and physicians completed a questionnaire on comfort and ease of use, and potential complications. In all 50 patients, the P-wave centric patch recording system identified rhythms in 23 patients (46%) that altered management, compared to 6 Holter patients (12%), PHolter ECG intervals having correlation coefficients of 0.93, 0.86, and 0.94, respectively. Finally, 48 patients (96%) preferred wearing the patch monitor. A single-channel ambulatory patch ECG monitor, designed specifically to ensure that the P-wave component of the ECG be visible, resulted in a significantly improved rhythm diagnosis and avoided inaccurate diagnoses made by the standard 3-channel Holter monitor. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Reaction routes leading to CO2 and CO in the Briggs-Rauscher oscillator: analogies between the oscillatory BR and BZ reactions.

    Muntean, Norbert; Szabó, Gabriella; Wittmann, Maria; Lawson, Thuy; Fülöp, János; Noszticzius, Zoltán; Onel, Lavinia


    With Fenton-type experiments, it is shown that the intense CO2/CO evolution in the Briggs-Rauscher (BR) reaction is due to decarboxylation/decarbonylation of organic free radicals. The metal ion applied in the Fenton-type experiments was Fe2+ or Ti3+ or Mn2+ combined with H2O2 or S2O(8)(2-) as a peroxide, whereas the organic substrate was malonic acid (MA) or a 1:1 mixture of MA and iodomalonic acid (IMA). Experiments with a complete BR system applying MA or the MA/IMA mixture indicate that practically all CO2 and CO comes from IMA. The decarboxylation/decarbonylation mechanisms of various iodomalonyl radicals can be analogous to that of the bromomalonyl radicals studied already in the Belousov-Zhabotinsky (BZ) reaction. It is found that an intense CO2/CO evolution requires the simultaneous presence of H2O2, IO3-, Mn2+, and IMA. It is suggested that the critical first step of this complex reaction takes place in the coordination sphere of Mn2+. That first step can initiate a chain reaction where organic and hydroperoxyl radicals are the chain carriers. A chain reaction was already found in a BZ oscillator as well. Therefore, the analogies between the BR and BZ oscillators are due to the fact that in both mechanisms, free radicals and, in most cases, also transition-metal complexes play an important role.

  18. Coherent fragmentation of 12C nuclei of momentum 4.5 GeV/ c per nucleon through the 8Beg.s.+4He channel in a nuclear photoemulsion containing lead nuclei

    Belaga, V. V.; Gerasimov, S. G.; Dronov, V. A.; Peresadko, N. G.; Pisetskaya, A. V.; Rusakova, V. V.; Fetisov, V. N.; Kharlamov, S. P.; Shesterkina, L. N.


    A two-particle channel in which an unbound nucleus of 8Be in the ground state (8Beg.s.) was one of the fragments was selected among events where 12C nuclei of momentum 4.5 GeV/c per nucleon undergo coherent dissociation into three alpha particles. The events in question were detected in a track nuclear photoemulsion containing lead nuclei, which was irradiated at the synchrophasotron of the Laboratory of High Energies at the Joint Institute for Nuclear Research (JINR, Dubna). The average transverse momentum of alpha particles produced upon the decay of 8Beg.s. nuclei was 87±6 MeV/ c, while that for "single" alpha (αs) particles was 123±15 MeV/ c. The average value of the transverse-momentum transfer in the reaction being considered, Pt(12C), was 223 ± 20 MeV/ c. The average value of the cross section for this channel involving Ag and Br target nuclei was 13 ± 4 mb, while the cross section for the reaction on the Pb nucleus was 40 ± 15 mb. The Coulomb dissociation contribution evaluated on the basis of the number of events where the momentum P t(12C) did not exceed 0.1 GeV/c saturated about 20%. In nine events, the measured total transverse energy of the fragments in the reference frame comoving with the decaying carbon nucleus did not exceed 0.45 MeV, which did not contradict the excitation of the participant 12C nucleus to the level at 7.65 MeV. The average value of the transverse momentum in those events was 234 ± 25 MeV/ c.

  19. Mode-specific multi-channel dynamics of the F- + CHD2Cl reaction on a global ab initio potential energy surface

    Szabó, István; Czakó, Gábor


    We report a detailed quasiclassical trajectory study for the dynamics of the ground-state and CH/CD stretching-excited F- + CHD2Cl(vCH/CD = 0, 1) → Cl- + CHD2F, HF + CD2Cl-, and DF + CHDCl- SN2, proton-, and deuteron-abstraction reactions using a full-dimensional global ab initio analytical potential energy surface. The simulations show that (a) CHD2Cl(vCH/CD = 1), especially for vCH = 1, maintains its mode-specific excited character prior to interaction, (b) the SN2 reaction is vibrationally mode-specific, (c) double inversion can occur and is enhanced upon CH/CD stretching excitations, (d) in the abstraction reactions the HF channel is preferred and the vCH/CD = 1 excitations significantly promote the HF/DF channels, (e) back-side rebound, back-side stripping, and front-side stripping are the dominant direct abstraction mechanisms based on correlated scattering- and attack-angle distributions, (f) the exact classical vibrational energy-based Gaussian binning (1GB) provides realistic mode-specific polyatomic product state distributions, (g) in the abstraction reactions CH and CD stretchings are not pure spectator modes and mainly ground-state products are produced, thus most of the initial energy transfers into product translation, and (h) the HF and DF product molecules are rotationally cold without any significant dependence on the reactant's and HF/DF vibrational states.

  20. An ab Initio/Rice-Ramsperger-Kassel-Marcus Study of the Reactions of Propenols with OH. Mechanism and Kinetics of H Abstraction Channels

    Zhou, Chong-Wen; Mebel, Alexander M.; Li, Xiang-Yuan


    Propenols have been found to be common intermediates in the hydrocarbon combustion and they are present in substantial concentrations in a wide range of flames. However, the kinetics properties of these species in combustion flames have not received much attention. In this work, the mechanism and kinetics of the OH hydrogen abstraction from propenols are investigated. Three stable conformations of propenols, (E)-1-propenol, (Z)-1-propenol, and syn-propen-2-ol, are taken into consideration. The potential energy profiles for the three reaction systems have been first investigated by the CCSD(T) method. The geometric parameters and relative energies of the reactants, reactant complexes, transition states, product complexes, and products have been investigated theoretically. The rate constants are calculated in the temperature range of 200-3000 K by the Variflex code based on the weak collision master equation/microcanonical variational RRKM theory. For all considered reactions, our results support a stepwise mechanism involving the formation of a reactant complex in the entrance channel and a product complex in the exit channel. In the reaction of OH with (E)-1-propenol, the hydrogen abstractions from the -CH3 and -OH sites are dominant and competitive with each other in the temperature range from 500 to 2000 K. Above 2000 K, the hydrogen abstraction from the -CH group bonded to O atom becomes dominant with a relative yield of 51.1% at 3000 K. In the reaction of OH with (Z)-1-propenol, the hydrogen abstractions from -CH3, -CH bonded to O atom, and -OH are preferable in the temperature range from 500 to 1800 K, with the first two channels being competitive with each other. Above 1800 K, the hydrogen abstraction reaction from the CH group bonded to the CH3 group becomes dominant with the branching ratio of 90.3% at 3000 K. In the reaction of OH with syn-propen-2-ol, the abstractions from the -CH3 and -OH sites are competitive with each other when the temperature is

  1. Effect of the size of experimental channels of the lead slowing-down spectrometer SVZ-100 (Institute for Nuclear Research, Moscow) on the moderation constant

    Latysheva, L. N.; Bergman, A. A.; Sobolevsky, N. M., E-mail: [Russian Academy of Sciences, Institute for Nuclear Research (Russian Federation); Ilic, R. D. [Vinca Institute of Nuclear Sciences (Serbia)


    Lead slowing-down (LSD) spectrometers have a low energy resolution (about 30%), but their luminosity is 10{sup 3} to 10{sup 4} times higher than that of time-of-flight (TOF) spectrometers. A high luminosity of LSD spectrometers makes it possible to use them to measure neutron cross section for samples of mass about several micrograms. These features specify a niche for the application of LSD spectrometers in measuring neutron cross sections for elements hardly available in macroscopic amounts-in particular, for actinides. A mathematical simulation of the parameters of SVZ-100 LSD spectrometer of the Institute for Nuclear Research (INR, Moscow) is performed in the present study on the basis of the MCNPX code. It is found that the moderation constant, which is the main parameter of LSD spectrometers, is highly sensitive to the size and shape of detecting volumes in calculations and, hence, to the real size of experimental channels of the LSD spectrometer.

  2. Barrier distributions and signatures of transfer channels in the Ca40+Ni58,64 fusion reactions at energies around and below the Coulomb barrier

    Bourgin, D.; Courtin, S.; Haas, F.; Stefanini, A. M.; Montagnoli, G.; Goasduff, A.; Montanari, D.; Corradi, L.; Fioretto, E.; Huiming, J.; Scarlassara, F.; Rowley, N.; Szilner, S.; Mijatović, T.


    Background: The nuclear structure of colliding nuclei is known to influence the fusion process. Couplings of the relative motion to nuclear shape deformations and vibrations lead to an enhancement of the sub-barrier fusion cross section in comparison with the predictions of one-dimensional barrier penetration models. This enhancement is explained by coupled-channels calculations including these couplings. The sub-barrier fusion cross section is also affected by nucleon transfer channels between the colliding nuclei. Purpose: The aim of the present experiment is to investigate the influence of the projectile and target nuclear structures on the fusion cross sections in the Ca40+Ni58 and Ca40+Ni64 systems. Methods: The experimental and theoretical fusion excitation functions as well as the barrier distributions were compared for these two systems. Coupled-channels calculations were performed using the ccfull code. Results: Good agreement was found between the measured and calculated fusion cross sections for the Ca40+Ni58 system. The situation is different for the Ca40+Ni64 system where the coupled-channels calculations with no nucleon transfer clearly underestimate the fusion cross sections below the Coulomb barrier. The fusion excitation function was, however, well reproduced at low and high energies by including the coupling to the neutron pair-transfer channel in the calculations. Conclusions: The nuclear structure of the colliding nuclei influences the fusion cross sections below the Coulomb barrier for both Ca40+Ni58,64 systems. Moreover, we highlighted the effect of the neutron pair-transfer channel on the fusion cross sections in Ca40+Ni64.


    Horst Koch


    Full Text Available The high speed of biological processes such as photosynthesis, enzymatic reactions or neuronal activity cannot completely be explained on the basis of classic physical approaches. Different quantum biology effects such as tunnelling have been postulated. We hypothetically admit that deceleration of electron velocity based on light-particle duality of electrons leads to time acceleration. Deceleration from the status of light towards a status of a particle may therefore speed up biochemical or biophysical reactions in the atomic or molecular dimension. Electrophysiological and biological phenomena are discussed on the basis of the hypothesis

  4. On Combined Effects of Heat Transfer and Chemical Reaction for the Flow through an Asymmetric Channel with Orthogonally Deformable Porous Walls

    Syed Tauseef Mohyud-Din


    Full Text Available The combined effects of heat transfer and chemical reaction are studied for the flow through a semi-infinite asymmetric channel with orthogonally deformable porous walls. The similarity transforms have been used to reduce the conservation laws to a corresponding system of nonlinear ordinary differential equations. The resulting equations are solved, both analytically and numerically, by using Homotopy Analysis Method (HAM and the fourth-order Runge-Kutta (RK-4 method, respectively. The convergence of the analytical solution is assured through the so-called total squared residual error analysis. The optimal values of auxiliary parameters are obtained by minimizing the total squared residual error.

  5. A facile and expedient one-pot three-component reaction leading to multifunctionalized stabilized phosphorus ylides

    Zahra Hassani; Zeinab Esfandiarpour


    A three-component reaction between triphenylphosphine, a dialkyl acetylenedicarboxylate and phthalazin-1(2H)-ones that affords novel organic phosphorane derivatives in good to excellent yields is reported. FTIR, 1H, 13C and 31P NMR and elemental analyses have been utilized to characterize the synthesized compounds.

  6. The homogeneously catalysed addition reaction of polyhalogenoalkanes to olefins by divalent arylnickel complexes: comparative reactivity and some important mechanistic leads

    Koten, G. van; Grove, D.M.; Verschuuren, A.H.M.; Beek, J.A.M. van


    In comparative studies some bis(ortho-chelated) arylnickel compounds of the type [Ni{C{6}H{3}(CH{2}NRR'){2}-2, 6}X] have been tested for activity in the Kharasch addition reaction of polyhalogenoalkanes to an alkene double bond using methyl methacrylate as substrate and carbon tetrachloride as reage

  7. Hydration Leads to Efficient Reactions of the Carbonate Radical Anion with Hydrogen Chloride in the Gas Phase.

    Tang, Wai Kit; van der Linde, Christian; Siu, Chi-Kit; Beyer, Martin K


    The carbonate radical anion CO3(•-) is a key intermediate in tropospheric anion chemistry. Despite its radical character, only a small number of reactions have been reported in the literature. Here we investigate the gas-phase reactions of CO3(•-) and CO3(•-)(H2O) with HCl under ultrahigh vacuum conditions. Bare CO3(•-) forms OHCl(•-) with a rate constant of 4.2 × 10(-12) cm(3) s(-1), which corresponds to an efficiency of only 0.4%. Hydration accelerates the reaction, and ligand exchange of H2O against HCl proceeds with a rate of 2.7 × 10(-10) cm(3) s(-1). Quantum chemical calculations reveal that OHCl(•-) is best described as an OH(•) hydrogen bonded to Cl(-), while the ligand exchange product is Cl(-)(HCO3(•)). Under tropospheric conditions, where CO3(•-)(H2O) is the dominant species, Cl(-)(HCO3(•)) is efficiently formed. These reactions must be included in models of tropospheric anion chemistry.

  8. Channeling the SmI₂ reactions to the radical path: radicals resisting reduction by SmI₂.

    Yella, Ramesh; Hoz, Shmaryahu


    Studies on the reaction of 4-(2,2-diphenylvinyl)pyridine with SmI2 revealed that the intermediate radical strongly resists further reduction to the corresponding anion. The resistance of the radical to accepting another electron is traced to its stabilization by the nitrogen lone pair. The literature suggests that oxygen may also play a role similar to that of nitrogen in directing the course of the reaction toward radical rather than to anionic chemistry.

  9. 微通道反应器中二氯丙醇环化反应%Research on cyclization reaction of dichloropropanol in a micro-channel reactor

    张跃; 李津石; 严生虎; 刘建武; 沈介发


    研究了微通道反应器内二氯丙醇的环化制备环氧氯丙烷的反应,考察了反应温度、原料配比、停留时间等单因素对环氧氯丙烷收率的影响。实验确定了较优的工艺参数组合:环化反应温度50℃,二氯丙醇与氢氧化钠的摩尔比1∶1.2,停留时间45 s,NaOH质量分数20%时ECH的收率达到95.2%。在微通道反应的时空转化率要比常规反应高出两个数量级。与传统的工艺方法相比,微通道反应中环氧氯丙烷的收率提高了10%,降低了过程的能耗,废水排放量减少了45%。%The paper is about the cyclization reaction of dichloropropanol preparing epoxy chloropropane in a micro-channel reactor.The influence of reaction temperature,the ratio of two materials,the detention time on the yield of epoxy chloropropane are studied.The optimal parameters for reaction process are obtained as 50 ℃ reaction temperature,1∶1.2 for the ratio of dichloropropanol and NaOH,45 s detention time,20% weight concentration of sodium hydroxide solution,under which the yield of the epoxy chloropropane can reach up to 95.2%.The STC in micro-channel reactor is more than 100 times of that in a regular reactor.Comparing with traditional technological process,this new micro-channel reaction process makes the yield of epoxy chloropropane increased by 10% with less energy consumption,and the waste water discharge reduced by 45%.

  10. Coupled-channel analysis of the $\\omega$-meson production in $\\pi N$ and $\\gamma N$ reactions for c.m. energies up to 2 GeV

    Shklyar, V; Mosel, U; Penner, G


    The pion- and photon induced reactions for the final states $\\gamma N$, $\\pi N$, $2\\pi N$, $\\eta N$, and $\\omega N$ are studied within a coupled-channel effective Lagrangian approach in the energy region from the pion threshold up to 2 GeV. To investigate the role of the nucleon resonances in the different reactions we include all known states with spin-$\\foh$,-$\\fth$, and -$\\ffh$ and masses below 2 GeV. We find a strong contribution from the $D_{15}(1675)$ resonance to the $\\pi N \\to \\omega N$ reaction. While the $F_{15}(1680)$ state only slightly influences the $\\omega $ meson production in the $\\pi N$ scattering its role is enhanced in the $\\omega$ photoproduction due to the large electromagnetic coupling of this resonance. We predict the beam asymmetry $\\Sigma_X$ to be a negative in the $\\gamma p \\to \\omega p$ reaction near to the threshold. Above the 1.85 GeV the asymmetry is found to change its sign and becomes positive at forward directions. The presented findings can be experimentally tested at GRAAL,...

  11. US outlook and German confidence : does the confidence channel work?

    Horn, Gustav Adolf


    One channel of business cycle shock transmission which gained attraction only recently is the confidence channel. The aim of the paper is to find out whether the confidence channel is actually working between the US and Germany. This is analysed using times series methods. In contrast to other studies the direct informational content of leading US indicators for German producer confidence and the significance of asymmetric reactions is tested. The results show that there is a relationship bet...

  12. Research progress in drug reactions on hERG potassium channels%药物对hERG钾通道作用机制研究进展

    林敏; 李泱; 张建成


    人ether-a-go-go-related gene (hERG)钾通道表达了延迟整流钾电流的快激活成分,对动作电位的复极至关重要.hERG钾电流不仅是抗心律失常作用的主要靶点,也是诸多药物增加尖端扭转型室速和心源性猝死风险的关键位点,而该电流的降低和(或)升高与基因突变或药物阻滞作用密切相关.随着对药物与hERG钾通道相互作用机制研究的深入,药物与通道孔道区蛋白结合位点的作用及其对通道转运的影响逐步被揭示,但这些药物对hERG作用的临床应用仍有待评价.%Human ether-a-go-go-related gene (hERG) potassium channels conduct the rapid component of the delayed rectifier potassium current ( Ikr). The reduction ( or increase ) of Ikr current due to either gene mutations or adverse drug effects would increase the risk of torsades de pointes and sudden cardiac death. This paper reviews various mechanisms of drug reactions of hERG potassium channels and the properties of major drug-protein reaction sites in the pore region and trafficking of hERG potassium channels under the influence of drugs. However, the effect of clinical administration of drugs on hERG remains unclear.

  13. Dynamical coupled-channels model of $K^- p$ reactions (II): Extraction of $\\Lambda^*$ and $\\Sigma^*$ hyperon resonances

    Kamano, H; Lee, T -S H; Sato, T


    Resonance parameters (pole masses and residues) associated with the excited states of hyperons, Lambda^* and Sigma^*, are extracted within a dynamical coupled-channels model developed recently in Phys. Rev. C 90, 065204 (2014) through a comprehensive partial-wave analysis of the K^- p --> barK N, pi Sigma, pi Lambda, eta Lambda, K Xi data up to invariant mass W = 2.1 GeV. We confirm the existence of resonances corresponding to most, if not all, of the four-star resonances rated by the Particle Data Group. We also find several new resonances, and in particular propose a possible existence of a new narrow J^P=3/2^+ Lambda resonance that couples strongly to the eta Lambda channel. The J^P=1/2^- Lambda resonances located below the barK N threshold are also discussed. Comparing our extracted pole masses with the ones from a recent analysis by the Kent State University group, some significant differences in the extracted resonance parameters are found, suggesting the need of more extensive and accurate data of K^- ...

  14. Daucosterol derived from Cordyceps (a Traditional Chinese Medicine as a possible lead compound for allergic transfusion reactions

    Jian Yang


    Full Text Available Allergic transfusion reaction is an anomaly that develops within several hours of transfusion which is usually treated by antihistamine. In the present study, we are looking into daucosterol, an extract of Traditional Chinese Medicine (TCM Cordyceps, as a potential inhibitor of histidine decarboxylase. The approach of molecular docking and Molecular Dynamics Simulation (MDS on a traditional anti-inflammatory Chinese medicine gave an atomic insight of the inhibition. The daucosterol was binding with a ΔG of -3.17 Kcal/mol, to inhibit histamine synthesis by binding to histidine decarboxylase, possibly via the flexible catalytic loop. Such inhibitors that were designed to block the flexibility of the catalytic loop are potential candidates for further drug development program.

  15. Measurements and Evaluation of Nuclear Reaction Cross Sections Leading to Various Practical Applications in Science and Technology

    Khandaker, Mayeen Uddin; Lee, Young Ouk; Cho, Young Sik


    This report contains the measurements and evaluation of production cross sections of some medically and technologically important radionuclides over the energy range 1-40 MeV by using a conventional stacked-foil activation technique combined with high purity germanium (HPGe) -ray spectrometry. The irradiations were done by using the external beam line of the MC-50 cyclotron at the Korea Institute of Radiological and Medical Sciences (KIRAMS). The standard cross sections for monitor reactions were taken from IAEA web site. Integral yields for the investigated radionuclides were deduced using the measured cross-sections. Reported data were compared with the available literature data, theoretical calculations by the codes TALYS and ALICE-IPPE, and a good overall agreement among them was found.

  16. Constraining the equation of state of nuclear matter from fusion hindrance in reactions leading to the production of superheavy elements

    Veselsky, M.; Klimo, J.; Ma, Yu-Gang; Souliotis, G. A.


    The mechanism of fusion hindrance, an effect preventing the synthesis of superheavy elements in the reactions of cold and hot fusion, is investigated using the Boltzmann-Uehling-Uhlenbeck equation, where Coulomb interaction is introduced. A strong sensitivity is observed both to the modulus of incompressibility of symmetric nuclear matter, controlling the competition of surface tension and Coulomb repulsion, and to the stiffness of the density-dependence of symmetry energy, influencing the formation of the neck prior to scission. The experimental fusion probabilities were for the first time used to derive constraints on the nuclear equation of state. A strict constraint on the modulus of incompressibility of nuclear matter K0=240 -260 MeV is obtained while the stiff density-dependences of the symmetry energy (γ >1 ) are rejected.

  17. Use of AlCl3 in Friedel Crafts arylation type reactions and beyond: an overview on the development of unique methodologies leading to N-heteroarenes.

    Sunke, Rajnikanth; Nallapati, Suresh Babu; Kumar, Jetta Sandeep; Shiva Kumar, K; Pal, Manojit


    As a privileged class of heterocyclic compounds N-heteroarenes have found enormous applications in many areas including medicinal/pharmaceutical chemistry and drug discovery. Consequently, a wide variety of methods have been reported for their synthesis. While not free from their own limitations the AlCl3 mediated methods appeared to have some particular advantages in preparing a number of useful N-heteroarenes. Besides the famous Friedel-Crafts (FC) alkylation/acylation reactions one such example is AlCl3-induced heteroarylation of arenes and heteroarenes (FC arylation type reactions) that can be used to prepare a certain class of N-heteroarenes in an operationally simple, efficient and cost effective manner. Interestingly, pyridine is not a good substrate in FC alkylation/acylation reactions whereas 2-chloropyridines are indeed effective in heteroarylation reaction. However, no systematic and detailed study regarding the application potential of this method was performed until 2002. Some other examples that emerged in the recent past include AlCl3 induced heteroarylation-cyclization, hydroarylation-heteroarylation, sulfonyl group migration etc. All these innovative methodologies allowed the direct access to several unique and novel N-heteroarenes some of which showed interesting pharmacological properties including anti-inflammatory, anti-cancer and antibacterial activities when tested in vitro. While unlike FC reactions many of these AlCl3 mediated methodologies are still in their initial stage of developments, a continuing effort to uncover their further potential in organic synthesis/medicinal chemistry is necessary. The current article provides an overview of these unique methodologies that highlight the use of AlCl3 beyond FC reactions leading to new N-heteroarenes.

  18. Effect of Interfacial Reactions on the Reliability of Lead-Free Assemblies after Board Level Drop Tests

    Xia, Yanghua; Lu, Chuanyan; Xie, Xiaoming


    The reliability of lead-free electronic assemblies after board level drop tests was investigated. Thin small outline package (TSOP) components with 42 FeNi alloy leads were reflow soldered on FR4 printed circuit boards (PCBs) with Sn3.0Ag0.5Cu (wt%) solder. The effects of different PCB finishes [organic solderability preservative (OSP) and electroless nickel immersion gold (ENIG)], multiple reflow (once and three times), and isothermal aging (500 h at 125°C after one time reflow) were studied. The ENIG finish showed better performance than its OSP counterparts. With the OSP finish, solder joints reflowed three times showed obvious improvement compared to those of the sample reflowed once, while aging led to apparent degradation. The results showed that intermetallic compound (IMC) types, IMC microstructure and solder microstructure compete with each other, all playing very important roles in the solder joint lifetime. The results also showed that it is important to specify adequate conditions for a given reliability assessment program, to allow meaningful comparison between results of different investigators.

  19. In Situ Solid-State Reactions Monitored by X-ray Absorption Spectroscopy: Temperature-Induced Proton Transfer Leads to Chemical Shifts.

    Stevens, Joanna S; Walczak, Monika; Jaye, Cherno; Fischer, Daniel A


    The dramatic colour and phase alteration with the solid-state, temperature-dependent reaction between squaric acid and 4,4'-bipyridine has been probed in situ with X-ray absorption spectroscopy. The electronic and chemical sensitivity to the local atomic environment through chemical shifts in the near-edge X-ray absorption fine structure (NEXAFS) revealed proton transfer from the acid to the bipyridine base through the change in nitrogen protonation state in the high-temperature form. Direct detection of proton transfer coupled with structural analysis elucidates the nature of the solid-state process, with intermolecular proton transfer occurring along an acid-base chain followed by a domino effect to the subsequent acid-base chains, leading to the rapid migration along the length of the crystal. NEXAFS thereby conveys the ability to monitor the nature of solid-state chemical reactions in situ, without the need for a priori information or long-range order.

  20. Design optimization of tall tubular lead/acid cells based on an analysis of the reaction distribution

    Asai, Kenji; Hatanaka, Teruhiro; Tsubota, Masaharu; Yonezu, Kunio; Ando, Koji

    In order to estimate the discharge performance of tall lead/acid cells (with tubular positives), changes in current and potential distributions with discharge progress were calculated with a computer on the basis of plate resistance and the current—potential—time relationship between small facing parts of positive and negative plates. The taller the cell, the larger the voltage drop along the plates. Thus, the discharge time became shorter despite a large amount of available active mass remaining in the bottom part of the plates. Various current-collector designs were evaluated, e.g., one with varying resistance at each height; a side conductor placed along the plates and connected to them at the top, centre and bottom, etc. Results revealed an optimum collector design with which the maximum discharge capacity could be obtained. Furthermore, it was shown that the side conductor markedly improved the discharge performance because the active mass near the connecting parts was appreciably used.

  1. MHD oscillatory channel flow, heat and mass transfer in a physiological fluid in presence of chemical reaction

    J.C. Misra


    Full Text Available In the present paper, the problem of oscillatory MHD flow of blood in a porous arteriole in presence of chemical reaction and an external magnetic field has been investigated. Heat and mass transfer during arterial blood flow are also studied. A mathematical model is developed and analyzed by using appropriate mathematical techniques. Expressions for the velocity profile, volumetric flow rate, wall shear stress and rates of heat and mass transfer have been obtained. Variations of the said quantities with different parameters are computed by using MATHEMATICA software. The quantitative estimates are presented through graphs and table.

  2. Influence of Chemical Reaction on Heat and Mass Transfer Flow of a Micropolar Fluid over a Permeable Channel with Radiation and Heat Generation

    Khilap Singh


    Full Text Available The effects of chemical reaction on heat and mass transfer flow of a micropolar fluid in a permeable channel with heat generation and thermal radiation is studied. The Rosseland approximations are used to describe the radiative heat flux in the energy equation. The model contains nonlinear coupled partial differential equations which have been transformed into ordinary differential equation by using the similarity variables. The relevant nonlinear equations have been solved by Runge-Kutta-Fehlberg fourth fifth-order method with shooting technique. The physical significance of interesting parameters on the flow and heat transfer characteristics as well as the local skin friction coefficient, wall couple stress, and the heat transfer rate are thoroughly examined.

  3. Analysis of transport phenomena and electrochemical reactions in a micro PEM fuel cell with serpentine gas flow channels

    Maher A.R. Sadiq Al-Baghdadi


    Full Text Available Micro-fuel cells are considered as promising electrochemical power sources in portable electronic devices. The presence of microelectromechanical system (MEMS technology makes it possible to manufacture the miniaturized fuel cell systems. The majority of research on micro-scale fuel cells is aimed at micro-power applications. Performance of micro-fuel cells are closely related to many factors, such as designs and operating conditions. CFD modeling and simulation for heat and mass transport in micro PEM fuel cells are being used extensively in researches and industrial applications to gain better understanding of the fundamental processes and to optimize the micro fuel cell designs before building a prototype for engineering application. In this research, full three-dimensional, non-isothermal computational fluid dynamics model of a micro proton exchange membrane (PEM fuel cell with serpentine gas flow channels has been developed. This comprehensive model accounts for the major transport phenomena such as convective and diffusive heat and mass transfer, electrode kinetics, transport and phase-change mechanism of water, and potential fields in a micro PEM fuel cell. The model explains many interacting, complex electrochemical, and transport phenomena that cannot be studied experimentally.

  4. Temporal coordination between ground reaction forces generated by leading and trailing limbs for propulsion during double stance phase in human walking.

    Sato, Yoichiro; Yamada, Norimasa


    Although it was reported that ground reaction forces (GRFs) are generated simultaneously by the leading and trailing limbs during the double stance phase, the finding was not examined by temporal analyses. Therefore, the purpose of the present study is to clarify how GRFs can act to propel the body in a forward direction during the double stance phase. GRFs were recorded during the double stance phase in eleven healthy volunteers. We calculated the instantaneous phase of the GRFs for vertical and anterior-posterior (AP) components, and then calculated the relative phase between the leading and trailing limbs for each component. The relative phase of the vertical component was approximately 180° (i.e., anti-phase), indicating that the lower limb transfers weight smoothly from the trailing limb to the leading limb. The relative phase of the AP component ranged from 40 to 55°, indicating that the AP component of the forces do not occur simultaneously, but instead has a lag. This finding suggests that the forces exerted by the leading and trailing limbs would temporally coordinate to propel the body in the forward direction. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Characterization of specific nuclear reaction channels by deconvolution in the energy space of the total nuclear cross-section of protons - applications to proton therapy and technical problems

    Ulmer, W


    The total nuclear cross-section Qtot(E) resulting from the interaction of protons with nuclei is decomposed in 3 different contributions: 1. elastic scatter at the complete nucleus, which adopts a part of the proton kinetic energy; 2. inelastic scatter at a nucleus, which changes its quantum numbers by vibrations, rotations, transition to highly excited states; 3. proper nuclear reactions with change of the mass and/or charge number. Then different particles leave the hit nucleus (neutrons, protons, etc.), which is now referred to as 'heavy recoil' nucleus. The scatter parts of Qtot(E) according to points 1 and 2 can be removed by a deconvolution acting at Qtot(E) in the energy space. The typical nuclear reaction channels are mainly characterized by resonances of a reduced cross-section function Qred(E). The procedure is applied to cross-sections of therapeutic protons and also to Cs55137 as an example with technical relevance (transmutations with the goal to drastically reduce its half-time).

  6. Infrared Stark and Zeeman spectroscopy of OH-CO: The entrance channel complex along the OH + CO → trans-HOCO reaction pathway

    Brice, Joseph T.; Liang, Tao; Raston, Paul L.; McCoy, Anne B.; Douberly, Gary E.


    Sequential capture of OH and CO by superfluid helium droplets leads exclusively to the formation of the linear, entrance-channel complex, OH-CO. This species is characterized by infrared laser Stark and Zeeman spectroscopy via measurements of the fundamental OH stretching vibration. Experimental dipole moments are in disagreement with ab initio calculations at the equilibrium geometry, indicating large-amplitude motion on the ground state potential energy surface. Vibrational averaging along the hydroxyl bending coordinate recovers 80% of the observed deviation from the equilibrium dipole moment. Inhomogeneous line broadening in the zero-field spectrum is modeled with an effective Hamiltonian approach that aims to account for the anisotropic molecule-helium interaction potential that arises as the OH-CO complex is displaced from the center of the droplet.

  7. Evaluation of the cross-sections of threshold reactions leading to the production of long-lived radionuclides during irradiation of steels by thermonuclear spectrum neutrons

    Blokhin, A I; Manokhin, V N; Mikhajlyukova, M V; Nasyrova, S M; Skripova, M V


    The present paper analyses and evaluates the cross-sections of threshold reactions leading to the production of long-lived radionuclides during the irradiation, by thermonuclear spectrum neutrons, of steels containing V, Ti, Cr, Fe and Ni. On the basis of empirical systematics. a new evaluation of the (n,2n), (n,p), (n,np), (n,alpha) and (n,n alpha) excitation functions is made for all isotopes of V, Ti, Cr, Fe and Ni and for intermediate isotopes produced in the chain from irradiated isotopes up to production of the long-lived radionuclides sup 3 sup 9 Ar, sup 4 sup 2 Ar, sup 4 sup 1 Ca, sup 5 sup 3 Mn, sup 6 sup 0 Fe, sup 6 sup 0 Co, sup 5 sup 9 Ni and sup 6 sup 3 Ni. A comparison is made with the experimental and other evaluated data.

  8. Electrodisintegration of the deuteron in nuclear reactions

    Liu, L. C.; Thaler, R. M.


    We estimate that the electrodisintegration of the deuteron contributes at least 25% of the total reaction cross section when the deuteron interacts with a nucleus of charge Z>~40 at a kinetic energy lower than 50 MeV. The neglect of this breakup channel in deuteron-nucleus optical potentials might lead to unrealistic predictions for the mass and energy dependence of the total deuteron reaction cross sections.

  9. Electrodisintegration of the deuteron in nuclear reactions

    Liu, L.C. (Theoretical Division, T-2, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (USA)); Thaler, R.M. (Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (USA) Department of Physics, Case Western Reserve University, Cleveland, Ohio 44106 (USA))


    We estimate that the electrodisintegration of the deuteron contributes at least 25% of the total reaction cross section when the deuteron interacts with a nucleus of charge {ital Z}{approx gt}40 at a kinetic energy lower than 50 MeV. The neglect of this breakup channel in deuteron-nucleus optical potentials might lead to unrealistic predictions for the mass and energy dependence of the total deuteron reaction cross sections.

  10. RNAi silencing of P/Q-type calcium channels in Purkinje neurons of adult mouse leads to episodic ataxia type 2.

    Salvi, Julie; Bertaso, Federica; Mausset-Bonnefont, Anne-Laure; Metz, Alexandra; Lemmers, Céline; Ango, Fabrice; Fagni, Laurent; Lory, Philippe; Mezghrani, Alexandre


    Episodic ataxia type-2 (EA2) is a dominantly inherited human neurological disorder caused by loss of function mutations in the CACNA1A gene, which encodes the CaV2.1 subunit of P/Q-type voltage-gated calcium channels. It remains however unknown whether the deficit of cerebellar CaV2.1 in adult is in direct link with the disease. To address this issue, we have used lentiviral based-vector RNA interference (RNAi) to knock-down CaV2.1 expression in the cerebellum of adult mice. We show that suppression of the P/Q-type channels in Purkinje neurons induced motor abnormalities, such as imbalance and ataxic gait. Interestingly, moderate channel suppression caused no basal ataxia, while β-adrenergic activation and exercise mimicked stress induced motor disorders. Moreover, stress-induced ataxia was stable, non-progressive and totally abolished by acetazolamide, a carbonic anhydrase inhibitor used to treat EA2. Altogether, these data reveal that P/Q-type channel suppression in adult mice supports the episodic status of EA2 disease. Copyright © 2014 Elsevier Inc. All rights reserved.

  11. First de novo KCND3 mutation causes severe Kv4.3 channel dysfunction leading to early onset cerebellar ataxia, intellectual disability, oral apraxia and epilepsy

    Smets, Katrien; Duarri, Anna; Deconinck, Tine; Ceulemans, Berten; van de Warrenburg, Bart P.; Zuechner, Stephan; Gonzalez, Michael Anthony; Schuele, Rebecca; Synofzik, Matthis; Van der Aa, Nathalie; De Jonghe, Peter; Verbeek, Dineke S.; Baets, Jonathan


    Background: Identification of the first de novo mutation in potassium voltage-gated channel, shal-related subfamily, member 3 (KCND3) in a patient with complex early onset cerebellar ataxia in order to expand the genetic and phenotypic spectrum. Methods: Whole exome sequencing in a cerebellar ataxia

  12. First de novo KCND3 mutation causes severe Kv4.3 channel dysfunction leading to early onset cerebellar ataxia, intellectual disability, oral apraxia and epilepsy

    Smets, K.; Duarri, A.; Deconinck, T.; Ceulemans, B.; Warrenburg, B.P.C. van de; Zuchner, S.; Gonzalez, M.A.; Schule, R.; Synofzik, M.; Aa, N. van der; Jonghe, P. De; Verbeek, D.S.; Baets, J.


    BACKGROUND: Identification of the first de novo mutation in potassium voltage-gated channel, shal-related subfamily, member 3 (KCND3) in a patient with complex early onset cerebellar ataxia in order to expand the genetic and phenotypic spectrum. METHODS: Whole exome sequencing in a cerebellar ataxia

  13. A theoretical study of the atmospherically important radical-radical reaction BrO + HO2; the product channel O2(a(1)Δg) + HOBr is formed with the highest rate.

    Chow, Ronald; Mok, Daniel K W; Lee, Edmond P F; Dyke, John M


    A theoretical study has been made of the BrO + HO2 reaction, a radical-radical reaction which contributes to ozone depletion in the atmosphere via production of HOBr. Reaction enthalpies, activation energies and mechanisms have been determined for five reaction channels. Also rate coefficients have been calculated, in the atmospherically important temperature range 200-400 K, for the two channels with the lowest activation energies, both of which produce HOBr: (R1a) HOBr(X(1)A') + O2(X(3)Σ) and (R1b) HOBr(X(1)A') + O2(a(1)Δg). The other channels considered are: (R2) BrO + HO2 → HBr + O3, (R3) BrO + HO2 → OBrO + OH and (R4) BrO + HO2 → BrOO + OH. For all channels, geometry optimization and frequency calculations were carried out at the M06-2X/AVDZ level, while relative energies of the stationary points on the reaction surface were improved at a higher level (BD(TQ)/CBS or CCSD(T)/CBS). The computed standard reaction enthalpies (ΔH) for channels (R1a), (R1b), (R2), (R3) and (R4) are -47.5, -25.0, -4.3, 14.9 and 5.9 kcal mol(-1), and the corresponding computed activation energies (ΔE) are 2.53, -3.07, 11.83, 35.0 and 37.81 kcal mol(-1). These values differ significantly from those obtained in earlier work by Kaltsoyannis and Rowley (Phys. Chem. Chem. Phys., 2002, 4, 419-427), particularly for channel (R1b), and reasons for this are discussed. In particular, the importance of obtaining an open-shell singlet wavefunction, rather than a closed-shell singlet wavefunction, for the transition state of this channel is emphasized. Rate coefficient calculations from computed potential energy surfaces were made for BrO + HO2 for the first time. Although channel (R1a) is the most exothermic, channel (R1b) has the lowest barrier height, which is negative (at -3.07 kcal mol(-1)). Most rate coefficient calculations were therefore made for (R1b). A two transition state model has been used, involving an outer and an inner transition state. The inner transition state was

  14. Catalytic effects of silver plasmonic nanoparticles on the redox reaction leading to ABTS˙(+) formation studied using UV-visible and Raman spectroscopy.

    Garcia-Leis, A; Jancura, D; Antalik, M; Garcia-Ramos, J V; Sanchez-Cortes, S; Jurasekova, Z


    ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) is a compound extensively employed to evaluate the free radical trapping capacity of antioxidant agents and complex mixtures such as biological fluids or foods. This evaluation is usually performed by using a colourimetric experiment, where preformed ABTS radical cation (ABTS˙(+)) molecules are reduced in the presence of an antioxidant causing an intensity decrease of the specific ABTS˙(+) UV-visible absorption bands. In this work we report a strong effect of silver plasmonic nanoparticles (Ag NPs) on ABTS leading to the formation of ABTS˙(+). The reaction of ABTS with Ag NPs has been found to be dependent on the interfacial and plasmonic properties of NPs. Specifically, this reaction is pronounced in the presence of spherical nanoparticles prepared by the reduction of silver nitrate with hydroxylamine (AgH) and in the case of star-shaped silver nanoparticles (AgNS). On the other hand, spherical nanoparticles prepared by the reduction of silver nitrate with citrate apparently do not react with ABTS. Additionally, the formation of ABTS˙(+) is investigated by surface-enhanced Raman scattering (SERS) and the assignment of the most intense vibrational bands of this compound is performed. The SERS technique enables us to detect this radical cation at very low concentrations of ABTS (∼2 μM). Altogether, these findings allow us to suggest the use of ABTS/Ag NPs-systems as reliable and easy going substrates to test the antioxidant capacity of various compounds, even at concentrations much lower than those usually used in the spectrophotometric assays. Moreover, we have suggested that ABTS could be employed as a suitable agent to investigate the interfacial and plasmonic properties of the metal nanoparticles and, thus, to characterize the nanoparticle metal systems employed for various purposes.

  15. First de novo KCND3 mutation causes severe Kv4.3 channel dysfunction leading to early onset cerebellar ataxia, intellectual disability, oral apraxia and epilepsy.

    Smets, Katrien; Duarri, Anna; Deconinck, Tine; Ceulemans, Berten; van de Warrenburg, Bart P; Züchner, Stephan; Gonzalez, Michael Anthony; Schüle, Rebecca; Synofzik, Matthis; Van der Aa, Nathalie; De Jonghe, Peter; Verbeek, Dineke S; Baets, Jonathan


    Identification of the first de novo mutation in potassium voltage-gated channel, shal-related subfamily, member 3 (KCND3) in a patient with complex early onset cerebellar ataxia in order to expand the genetic and phenotypic spectrum. Whole exome sequencing in a cerebellar ataxia patient and subsequent immunocytochemistry, immunoblotting and patch clamp assays of the channel were performed. A de novo KCND3 mutation (c.877_885dupCGCGTCTTC; p.Arg293_Phe295dup) was found duplicating the RVF motif and thereby adding an extra positive charge to voltage-gated potassium 4.3 (Kv4.3) in the voltage-sensor domain causing a severe shift of the voltage-dependence gating to more depolarized voltages. The patient displayed a severe phenotype with early onset cerebellar ataxia complicated by intellectual disability, epilepsy, attention deficit hyperactivity disorder, strabismus, oral apraxia and joint hyperlaxity. We identified a de novo KCND3 mutation causing the most marked change in Kv4.3's channel properties reported so far, which correlated with a severe and unique spinocerebellar ataxia (SCA) type 19/22 disease phenotype.

  16. Development of a chemical kinetic measurement apparatus and the determination of the reaction rate constants for lithium-lead/water interaction

    Biney, P.O.


    An experimental set-up for accurate measurement of hydrogen generation rate in Lithium-Lead (Li[sub 17]Pb[sub 83]) Steam or water interactions has been designed. The most important features of the design include a pneumatic actuated quick opening and closing high temperature all stainless steel valve used to control the reaction time and the placement of most measuring devices below a water line to minimize leakage of the hydrogen collected. A PC based data acquisition and control system provides remote process sequencing, acquisition and control of all major components of the set-up. Initial tests indicate that the first design objective of maintaining leakproof gas collection chamber has been achieved. Initial pressure tests indicated that the pressure drop over a time span of 30 minutes was within the tolerance of the pressure transducer used to measure the pressure (within 0.690 kPa) at a nominal system pressure of 685 kPa. The experimental system hardware, data acquisition and control programs and data analysis program have been completed, tested and are currently functional.

  17. The copper catalysed reaction of sodium methoxide with aryl bromides. A mechanistic study leading to a facile synthesis of anisole derivatives

    Koten, G. van; Aalten, H.L.; Grove, D.M.; Kuilman, T.; Piekstra, O.G.; Hulshof, L.A.; Sheldon, R.A.


    The copper catalysed reaction of unactivated aryl bromides with sodium methoxide has been investigated by studying a number of parameters (copper catalyst, cosolvent, concentration and relative ratio of the reactants, additives and aryl bromide substituents) which influence this reaction. The

  18. Histopathology and immune histochemistry of red tattoo reactions. Interface dermatitis is the lead pathology, with increase in T-lymphocytes and Langerhans cells suggesting an allergic pathomechanism

    Høgsberg, T; Thomsen, B M; Serup, J


    BACKGROUND: The majority of tattoo reactions are affiliated to red pigmented areas and often suspected to be allergic in nature. A sizeable series of biopsies of such reactions has not previously been performed. The aim of this study was to type and grade epidermal and dermal changes in tattoo...... reactions to red/red nuances by microscopy and immunochemistry relevant for the assessment of a possible allergic pathomechanism. METHODS: Skin biopsies were taken from red tattoo reactions, graded by conventional microscopy and stained for T and B-lymphocytes, Langerhans cells, macrophages and tumour......-α was common. CONCLUSION: The predominant histological pattern of chronic tattoo reactions in red/red nuances is interface dermatitis. T-lymphocytes and Langerhans cells are increased suggesting an allergic pathomechanism. TNF-α may contribute to reactions. In many cases, overlapping reactive patterns were...

  19. The Relevance of the De Broglie Velocity (V sub 1 = h/2md sub 1) to Shock Loading Induced Reactions in Lead Azide


    induced reactive pressure levels for dextrinated and single crystal lead azide are compared to predicted Pv1 magnitudes. PV1 = P. CL V1 where V, = h...EXPERIMENTAL REACTIVE SHOCK PRESSURES AND COMPARISON WITH Pv1 PREDICTIONS .................. 4 A. Dextrinated Lead Azide (DLA... Dextrinated Lead Azide (DLA) DLA is a mixture of lead azide and dextrin . Dextrination of lead azide provides han- dling and safety benefits 15, Vol. 2, Chpt

  20. Excitation functions and yields of proton induced reactions at intermediate energies leading to important diagnostics radioisotopes of {sup 52}Fe, {sup 77}Br, {sup 82}Rb, {sup 97}Ru, {sup 111}In, {sup 123}I, {sup 127}Xe, {sup 128}Cs, {sup 178}Ta and {sup 201}Tl

    Rurarz, E. [Soltan Inst. for Nuclear Studies, Otwock-Swierk (Poland)


    This report describes investigations of the excitation functions of the proton induced reactions on 14 targets (Mn, Co, Br, Rb, {sup 99}Tc, {sup 113}Cd, {sup 114}Cd, Cd, I, Cs, Ta, {sup 206,207,208}Pb) leading directly or indirectly to the formation of radionuclides {sup 52}Fe, {sup 77}Br, {sup 82}Rb, {sup 97}Ru, {sup 111}In, {sup 123}I, {sup 127}Xe, {sup 128}Cs, {sup 178}Ta and {sup 201}Tl frequently used in diagnostic procedures of nuclear medicine. The measurements of the excitation functions were made over a wide proton energy range from the reaction threshold up to 100 MeV using the stacked foil (or pellet) technique. Small energy steps were used to allow for accurate determination of the structure of excitation functions. For {sup 97}Ru, {sup 111}In and {sup 127}Xe formation with protons, new reaction channels and targets were used and data concerning this method are published for the first time. The data for {sup 52}Fe, {sup 77}Br, {sup 82}Rb, {sup 123}I, {sup 128}Cs and {sup 201}Tl obtained in the present work for the E{sub p}=70-100 MeV region are also published for the first time. The measured excitation functions for the formation of desired (and undesired) radionuclides (altogether 28 excitation functions) are compared with the theoretical ones calculated on the basis of a hybrid model of nuclear reactions in the form of the Overlaid Alice computer code. In order to determine the contribution of the competitive reaction channels to the purity of the produced, desired radionuclide, the excitation functions of the accompanying reactions were also calculated. The 122 calculated excitation functions for the possible contaminant are given. The comparison of experimental excitation functions with the results of model calculations showed satisfactory agreement; no parameter adjustment for individual reaction products was undertaken. Production yields for 28 radionuclides mentioned above were determined (author). 262 refs, 65 figs, 34 tabs.

  1. Understanding Gender Differences in Children's Risk Taking and Injury: A Comparison of Mothers' and Fathers' Reactions to Sons and Daughters Misbehaving in Ways that Lead to Injury

    Morrongiello, Barbara A.; Zdzieborski, Daniel; Normand, Jackie


    This study compared reactions of mothers and fathers to the risk taking behavior of sons and daughters. Mother-father pairs (N = 52) imagined their 2-year-old boy or girl behaving in risky ways in common home situations that could, and did, result in injury. Emotional and parenting reactions to the behaviors were assessed before and after injury.…

  2. Quantum chemical investigation of the reaction of O(32) with certain hydrocarbon radicals

    Ashutosh Gupta; R P Singh; V B Singh; Brijesh Kumar Mishra; N Sathyamurthy


    The reaction of ground-state atomic oxygen [O(32)] with methyl, ethyl, -propyl and isopropyl radicals has been studied using the density functional method and the complete basis set model. The energies of the reactants, products, reaction intermediates and various transition states as well as the reaction enthalpies have been computed. The possible product channels and the reaction pathways are identified in each case. In the case of methyl radical the minimum energy reaction pathway leads to the products CO + H2 + H. In the case of ethyl radical the most facile pathway leads to the products, methanal + CH3 radical. For propyl radical (- and iso-), the minimum energy reaction pathway would lead to the channel containing ethanal + methyl radical.

  3. Direct ab initio molecular dynamics study on a microsolvated SN2 reaction of OH-(H2O) with CH3Cl

    Tachikawa, Hiroto


    Reaction dynamics for a microsolvated SN2 reaction OH-(H2O)+CH3Cl have been investigated by means of the direct ab initio molecular dynamics method. The relative center-of-mass collision energies were chosen as 10, 15, and 25kcal/mol. Three reaction channels were found as products. These are (1) a channel leading to complete dissociation (the products are CH3OH+Cl-+H2O: denoted by channel I), (2) a solvation channel (the products are Cl-(H2O)+CH3OH: channel II), and (3) a complex formation channel (the products are CH3OH ⋯H2O+Cl-: channel III). The branching ratios for the three channels were drastically changed as a function of center-of-mass collision energy. The ratio of complete dissociation channel (channel I) increased with increasing collision energy, whereas that of channel III decreased. The solvation channel (channel II) was minor at all collision energies. The selectivity of the reaction channels and the mechanism are discussed on the basis of the theoretical results.

  4. SN2 and SN2' reaction dynamics of cyclopropenyl chloride with halide ion : A direct ab initio molecular dynamics (MD) study

    Tachikawa, Hiroto


    Direct ab initio molecular dynamics (MD) calculations have been carried out for the reaction of cyclopropenyl chloride with halide ion (F–) (F– + (CH)3Cl → F(CH)3 + Cl–) in gas phase. Both SN2 and SN2′ channels were found as product channels. These channels are strongly dependent on the collision angle of F– to the target (CH)3Cl molecule. The collision at one of the carbon atoms of the C=C double bond leads to the SN2′ reaction channel; whereas the collision at the methylene carbon atom lead...

  5. KANTBP 2.0: New version of a program for computing energy levels, reaction matrix and radial wave functions in the coupled-channel hyperspherical adiabatic approach

    Chuluunbaatar, O.; Gusev, A. A.; Vinitsky, S. I.; Abrashkevich, A. G.


    A FORTRAN 77 program for calculating energy values, reaction matrix and corresponding radial wave functions in a coupled-channel approximation of the hyperspherical adiabatic approach is presented. In this approach, a multi-dimensional Schrödinger equation is reduced to a system of the coupled second-order ordinary differential equations on a finite interval with homogeneous boundary conditions: (i) the Dirichlet, Neumann and third type at the left and right boundary points for continuous spectrum problem, (ii) the Dirichlet and Neumann type conditions at left boundary point and Dirichlet, Neumann and third type at the right boundary point for the discrete spectrum problem. The resulting system of radial equations containing the potential matrix elements and first-derivative coupling terms is solved using high-order accuracy approximations of the finite element method. As a test desk, the program is applied to the calculation of the reaction matrix and radial wave functions for 3D-model of a hydrogen-like atom in a homogeneous magnetic field. This version extends the previous version 1.0 of the KANTBP program [O. Chuluunbaatar, A.A. Gusev, A.G. Abrashkevich, A. Amaya-Tapia, M.S. Kaschiev, S.Y. Larsen, S.I. Vinitsky, Comput. Phys. Commun. 177 (2007) 649-675]. Program summaryProgram title: KANTBP Catalogue identifier: ADZH_v2_0 Program summary URL: Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, No. of lines in distributed program, including test data, etc.: 20 403 No. of bytes in distributed program, including test data, etc.: 147 563 Distribution format: tar.gz Programming language: FORTRAN 77 Computer: Intel Xeon EM64T, Alpha 21264A, AMD Athlon MP, Pentium IV Xeon, Opteron 248, Intel Pentium IV Operating system: OC Linux, Unix AIX 5.3, SunOS 5.8, Solaris, Windows XP RAM: This depends on the

  6. KANTBP: A program for computing energy levels, reaction matrix and radial wave functions in the coupled-channel hyperspherical adiabatic approach

    Chuluunbaatar, O.; Gusev, A. A.; Abrashkevich, A. G.; Amaya-Tapia, A.; Kaschiev, M. S.; Larsen, S. Y.; Vinitsky, S. I.


    A FORTRAN 77 program is presented which calculates energy values, reaction matrix and corresponding radial wave functions in a coupled-channel approximation of the hyperspherical adiabatic approach. In this approach, a multi-dimensional Schrödinger equation is reduced to a system of the coupled second-order ordinary differential equations on the finite interval with homogeneous boundary conditions of the third type. The resulting system of radial equations which contains the potential matrix elements and first-derivative coupling terms is solved using high-order accuracy approximations of the finite-element method. As a test desk, the program is applied to the calculation of the energy values and reaction matrix for an exactly solvable 2D-model of three identical particles on a line with pair zero-range potentials. Program summaryProgram title: KANTBP Catalogue identifier: ADZH_v1_0 Program summary URL: Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, No. of lines in distributed program, including test data, etc.: 4224 No. of bytes in distributed program, including test data, etc.: 31 232 Distribution format: tar.gz Programming language: FORTRAN 77 Computer: Intel Xeon EM64T, Alpha 21264A, AMD Athlon MP, Pentium IV Xeon, Opteron 248, Intel Pentium IV Operating system: OC Linux, Unix AIX 5.3, SunOS 5.8, Solaris, Windows XP RAM: depends on (a) the number of differential equations; (b) the number and order of finite-elements; (c) the number of hyperradial points; and (d) the number of eigensolutions required. Test run requires 30 MB Classification: 2.1, 2.4 External routines: GAULEG and GAUSSJ [W.H. Press, B.F. Flanery, S.A. Teukolsky, W.T. Vetterley, Numerical Recipes: The Art of Scientific Computing, Cambridge University Press, Cambridge, 1986] Nature of problem: In the hyperspherical adiabatic

  7. Downregulation of L-type Ca2+ channel in rat mesenteric arteries leads to loss of smooth muscle contractile phenotype and inward hypertrophic remodeling.

    Kudryavtseva, Olga; Herum, Kate Møller; Dam, Vibeke Secher; Straarup, Marthe Simonsen; Kamaev, Dmitry; Briggs Boedtkjer, Donna M; Matchkov, Vladimir V; Aalkjær, Christian


    L-type Ca(2+) channels (LTCCs) are important for vascular smooth muscle cell (VSMC) contraction, as well as VSMC differentiation, as indicated by loss of LTCCs during VSMC dedifferentiation. However, it is not clear whether loss of LTCCs is a primary event underlying phenotypic modulation or whether loss of LTCCs has significance for vascular structure. We used small interference RNA (siRNA) transfection in vivo to investigate the role of LTCCs in VSMC phenotypic expression and structure of rat mesenteric arteries. siRNA reduced LTCC mRNA and protein expression in rat mesenteric arteries 3 days after siRNA transfection to 12.7 ± 0.7% and 47.3 ± 13%, respectively: this was associated with an increased resting intracellular Ca(2+) concentration ([Ca(2+)]i). Despite the high [Ca(2+)]i, the contractility was reduced (tension development to norepinephrine was 3.5 ± 0.2 N/m and 0.8 ± 0.2 N/m for sham-transfected and downregulated arteries respectively; P arteries downregulated for LTCCs. Phenotypic changes were associated with a 45% increase in number of VSMCs and a consequent increase of media thickness and media area. Ten days after siRNA transfection arterial structure was again normalized. The contractile responses of LTCC-siRNA transfected arteries were elevated in comparison with matched controls 10 days after transfection. The study provides strong evidence for causal relationships between LTCC expression and VSMC contractile phenotype, as well as novel data addressing the complex relationship between VSMC contractility, phenotype, and vascular structure. These findings are relevant for understanding diseases, associated with phenotype changes of VSMC and vascular remodeling, such as atherosclerosis and hypertension.

  8. Thermal decomposition of a molecular material {N(n-C4H94[FeIIFeIII(C2O43]}∞ leading to ferrite: A reaction kinetics study

    Bhattacharjee Ashis


    Full Text Available A multi-step thermal decomposition of a molecular precursor, {N(n-C4H94[FeIIFeIII(C2O43}∞ has been studied using non-isothermal thermogravimetry (TG measurements in the temperature range 300 to ~800 K at multiple heating rates (5, 10 and 20 K min-1. The thermal decomposition of the oxalate-based complex proceeds stepwise through a series of intermediate reactions. Two different isoconversional methods, namely, improved iterative method and model-free method are employed to evaluate the kinetic parameters: activation energy and rate of reaction, and the most probable reaction mechanism of thermal decomposition is also determined. The different reaction pathways leading to different steps in the TG profile have also been explored which are supplemented by earlier experimental observations of the present authors.

  9. 微通道反应器中二氯丙醇环化反应研究%Researches on cyclization reaction of dichloropropanol in the micro-channel reactor

    张跃; 李津石; 严生虎; 刘建武; 沈介发


    The cyclization reaction of dichloropropanol to preapare epoxy chloropropane in the micro-channel reactor was investigated in this study. The influences of reaction temperature, ratio of two materials and the detention time on the yield of epoxy chloropropane were carried out. The optimal reaction conditions are shown as follows: 50t of reaction temperature, 1: 1. 2 of molar ratio of dichloropropanol and NaOH,45 seconds of detention time and 20 wt% of sodium hydroxide solution concentration. The yield of the epoxy chloropropane can reach 95. 2%. The STC in micro-channel reactor is 100 times greater than that in the regular reaction. Compared with the traditional process, this new micro-channel reaction process increases the yield of epoxy chloropropane by 10% , decreases the waste water discharge by 45% and reduces the energy consumption at the same time.%研究了微通道反应器内二氯丙醇的环化制备环氧氯丙烷的反应,考察了反应温度、原料配比、停留时间等单因素对环氧氯丙烷收率的影响.实验确定了较优的工艺参数组合:环化反应温度50℃,二氯丙醇与氢氧化钠的摩尔比1∶1.2,停留时间45 s,NaOH质量分数20%时,ECH的收率达到95.2%.在微通道反应的时空转化率要比常规反应高出2个数量级.与传统的工艺方法相比,微通道反应中环氧氯丙烷的收率提高了10%,降低了过程的能耗,废水排放量减少了45%.

  10. A novel one-pot de-blocking and conjugation reaction step leads to process intensification in the manufacture of PEGylated insulin IN-105.

    Hazra, Partha; Chatterjee, Amarnath; Shabandri, Qais; Adhikary, Laxmi; Dave, Nitesh; Buddha, Madhavan


    Bio-catalytic in vitro multistep reactions can be combined in a single step in one pot by optimizing multistep reactions under identical reaction condition. Using this analogy, the process of making PEGylated insulin, IN-105, was simplified. Instead of taking the purified active insulin bulk powder as the starting material for the conjugation step, an insulin process intermediate, partially purified insulin ester, was taken as starting material. Process intensification (PI) was established by performing a novel de-blocking (de-esterification) of the partially purified insulin ester and conjugation at B-29 Lys residue of B chain with a short-chain methoxy polyethylene glycol (mPEG) in a single-pot reactor. The chromatographic profile at the end of the reaction was found similar irrespective of whether both the reactions were performed sequentially or simultaneously. The conjugated product of interest, IN-105 (conjugation at LysB(29)), was purified from the heterogeneous mixture of conjugated products. The new manufacturing process was deduced to be more simplified and economical in making the insulin conjugates as several downstream purification steps could be circumvented. The physicochemical characteristics of IN-105 manufactured through this economic process was found to be indifferent from the product formed through the traditional process where the conjugation starting material was purified from bulk insulin.

  11. Comparison of Schroedinger and Dirac coupled-channels analyses of the sup 28 Si( p , p prime ) sup 28 Si reaction at 500 MeV

    de Swiniarski, R.; Beatty, D.; Donoghue, E.; Fergerson, R.W.; Franey, M.; Gazzaly, M.; Glashausser, C.; Hintz, N.; Jones, K.W.; McClelland, J.B.; Nanda, S.; Plum, M. (Institut des Sciences Nucleaires, 53, avenue des Martyrs, F-38026 Grenoble CEDEX (France) Serin Physics Laboratory, Rutgers University, Piscataway, NJ (USA) School of Physics and Astronomy, University of Minnesota, Minneapolis, MN (USA) Los Alamos Meson Physics Facility, Los Alamos National Laboratory, Los Alamos, NM (USA))


    Analyzing powers have been measured for elastic and inelastic scattering of 500-MeV protons from {sup 28}Si. These data for the first 0{sup +}, 2{sup +}, and 4{sup +} states and the corresponding cross-section data have been analyzed with both Schroedinger and Dirac equation phenomenological coupled-channels methods. Good, qualitatively similar, results are achieved with the two methods.

  12. Nuclear molecules and their deexcitation channels, case of Cr{sup 48} generated by the Mg{sup 24} + Mg{sup 24} resonant reaction; Molecules nucleaires et leurs modes de desexcitation: le cas du {sup 48}Cr et de la reaction resonante {sup 24}Mg + {sup 24}Mg

    Salsac, M.D


    This work is dedicated to the study of the resonance (E = 45,7 MeV, J{sup {pi}} = 36{sup +}, {gamma} = 170 keV) of the Mg{sup 24} + Mg{sup 24} composite nucleus. The PRISMA fragment spectrometer combined with the CLARA gamma detector have been used to study the deexcitation through inelastic channels of the composite system. It is showed that the resonant flux is mainly observed in the inelastic channels involving the contributions 0{sup +}, 2{sup +} and 4{sup +} of the band based on the fundamental state of Mg{sup 24}. This is in good agreement with the theoretical predictions of the molecular model of Uegaki and Abe. Only 30% of the resonant flux has been observed in the inelastic channels and in the transfer channels. The missing flux has been investigated in the fusion/evaporation deexcitation channels with the GASP gamma multi-detector. A weak resonant effect has been highlighted in some residual nuclei such as Ti{sup 45}, Ca{sup 42} and K{sup 39}. A link between the prolate di-nucleus Ca{sup 48} generated in Mg{sup 24} + Mg{sup 24} reaction and a Cr{sup 48} nucleus that has just undergone a Jacobi transition from oblate to prolate, has been discovered. To explain a part of the missing flux it is suggested that the dipolar giant resonance might feed very deformed nuclei through particle emission.

  13. Mechanism of ({sup 14}N, {sup 12}B) reactions at intermediate energy leading to large spin-polarization of {sup 12}B

    Mitsuoka, Shin-ichi [Osaka Univ., Ibaraki (Japan). Research Center for Nuclear Physics; Shimoda, Tadashi; Miyatake, Hiroari [and others


    To study mechanisms of the ({sup 14}N, {sup 12}B) reactions at intermediate energies, double differential cross section and nuclear spin-polarization of the {sup 12}B projectile-like fragments have been measured as a function of longitudinal momentum in the angular range of 0deg - 9deg. Large spin-polarization of the reaction products {sup 12}B has been observed in the {sup 9}Be({sup 14}N, {sup 12}B) reaction at 39.3 MeV/u. The momentum distributions at forward angles exhibit characteristic features which can not be understood by the current projectile fragmentation picture. It is shown that by assuming the existence of direct two-proton transfer process in addition to the fragmentation process, both the cross section and polarization of {sup 12}B fragments are successfully explained. The target and incident energy dependence of the momentum distribution are also explained reasonably. (author)

  14. Polarization for arbitrary discrete memoryless channels

    Sasoglu, Eren; Telatar, Emre; Arikan, Erdal


    Channel polarization, originally proposed for binary-input channels, is generalized to arbitrary discrete memoryless channels. Specifically, it is shown that when the input alphabet size is a prime number, a similar construction to that for the binary case leads to polarization. This method can be extended to channels of composite input alphabet sizes by decomposing such channels into a set of channels with prime input alphabet sizes. It is also shown that all discrete memoryless channels can...

  15. Activation of electrophilicity of stable Y-delocalized carbamate cations in intramolecular aromatic substitution reaction: evidence for formation of diprotonated carbamates leading to generation of isocyanates.

    Kurouchi, Hiroaki; Kawamoto, Kyoko; Sugimoto, Hiromichi; Nakamura, Satoshi; Otani, Yuko; Ohwada, Tomohiko


    Although cations with three heteroatoms, such as monoprotonated guanidine and urea, are stabilized by Y-shaped conjugation and such Y-conjugated cations are sufficiently basic to be further protonated (or protosolvated) to dications in strongly acid media, only O-monoprotonated species have been detected in the case of carbamates even in magic acid. We found that the trifluoromethanesulfonic acid-catalyzed cyclization of arylethylcarbamates proceeds to afford dihydroisoquinolones in high yield. In strong acids, methyl carbamates are fully O-monoprotonated, and these monocations do not undergo cyclization even under heating. But, as the acidity of the reaction medium is further increased, the cyclization reaction of methyl phenethylcarbamates starts to proceed as a first-order reaction, with a linear relationship between rate and acidity. The sign and magnitude of the entropy of activation ΔS(‡) were found to be similar to those of other A(Ac)1 reactions. These results strongly support the idea that further protonation of the O-protonated carbamates is involved in the cyclization, but the concentration of the dications is very low and suggests that the rate-determining step is dissociation of methanol from the diprotonated carbamate to generate protonated isocyanate, which reacts with the aromatic ring. Therefore, O-protonated carbamates are weak bases in sharp contrast to other Y-shaped monocations.

  16. Diversion of the melanin synthetic pathway by dopamine product scavengers: A quantum chemical modeling of the reaction mechanisms

    T. B. Demissie


    Full Text Available We report the stability and reactivity of the oxidation products as well as L-cysteine and N-acetylcysteine adducts of dopamine studied using quantum chemical calculations. The overall reactions studied were subdivided into four reaction channels. The first reaction channel is the oxidation of dopamine to form dopaminoquinone. The second reaction channel leads to melanin formation through subsequent reactions. The third and fourth reaction channels are reactions leading to the formation of dopaminoquinone adducts which are aimed to divert the synthesis of melanin. The results indicate that L-cysteine and N-acetylcysteine undergo chemical reactions mainly at C5 position of dopaminoquinone. The analyses of the thermodynamic energies indicate that L-cysteine and N-acetylcysteine covalently bind to dopaminoquinone by competing with the internal cyclization reaction of dopaminoquinone which leads to the synthesis of melanin. The analysis of the results, based on the reaction free energies, is also supported by the investigation of the natural bond orbitals of the reactants and products.

  17. 多通道反应O(3P)+CH2F的理论研究%Vibrational Mode Analysis for the Multi-channel Reactions of O(3P) with CH2F

    曹小龙; 郭丽


    用密度泛函理论研究了氧原子与氟代甲基自由基的反应.反应中出现的所有物种的平衡构型用B3LYP方法在6-311++G(2 d,2p)基组水平上进行了优化,同时对各物种进行了频率分析;在同一理论水平上计算了各反应通道的势能面变化,分析了反应物、中间体、过渡态、产物的振动模式随反应途径的变化关系,阐明了该多通道反应的反应机理.%All species involved in the multi-channel reaction of an oxygen atom with a fluorinated methyl radical have been investigated using density functional theory (DFT) . The geometries of the reactants, intermediates, transition states and products are optimized at the B3LYP/6-311 + + G(2 d, 2p) level. The potential energy surface for this reaction is calculated at the same level of theory. Various possible production channels involved in the reaction of O(3 P) +CH2F are examined. The vibrational mode analysis is used to elucidate the relationship between the transition states, intermediates and the products. The extensive investigation shows that the reaction mechanism is reliable.

  18. Study of exclusive one-pion and one-eta production using hadron and dielectron channels in pp reactions at kinetic beam energies of 1.25 GeV and 2.2 GeV with HADES

    Agakishiev, G.; Chernenko, S.; Fateev, O.; Ierusalimov, A.; Zanevsky, Y. [Joint Institute of Nuclear Research, Dubna (Russian Federation); Alvarez-Pol, H.; Cabanelas, P.; Garzon, J.A.; Sanchez, M. [Univ. de Santiago de Compostela (Spain); Balanda, A.; Dybczak, A.; Kozuch, A.; Michalska, B.; Otwinowski, J.; Przygoda, W.; Salabura, P.; Trebacz, R.; Wisniowski, M.; Wojcik, T. [Jagiellonian University of Cracow, Smoluchowski Institute of Physics, Krakow (Poland); Bassini, R.; Iori, I. [Sezione di Milano, Istituto Nazionale di Fisica Nucleare, Milano (Italy); Boehmer, M.; Christ, T.; Eberl, T.; Friese, J.; Gernhaeuser, R.; Jurkovic, M.; Maier, L.; Sailer, B. [Technische Univ. Muenchen, Physik Dept. E12, Garching (Germany); Bokemeyer, H.; Holzmann, R.; Koenig, I.; Koenig, W.; Kolb, B.W.; Lang, S.; Muench, M.; Pechenov, V.; Rustamov, A.; Schwab, E.; Sturm, C.; Traxler, M.; Yurevich, S.; Zumbruch, P. [GSI Helmholtz-Zentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany); Boyard, J.L.; Gumberidze, M.; Hennino, T.; Liu, T.; Moriniere, E.; Ramstein, B.; Roy-Stephan, M. [CNRS/IN2P3 - Univ. Paris Sud, Institut de Physique Nucleaire, Orsay (France); Destefanis, M.; Gilardi, C.; Kuehn, W.; Metag, V.; Perez Cavalcanti, T.; Spruck, B.; Toia, A. [Justus Liebig Univ. Giessen, II. Physikalisches Inst., Giessen (Germany); Dohrmann, F.; Kaempfer, B.; Kanaki, K.; Kotte, R.; Naumann, L.; Wuestenfeld, J. [Helmholtz-Zentrum Dresden-Rossendorf, Inst. fuer Strahlenphysik, Dresden (Germany); Fabbietti, L.; Lapidus, K. [Excellence Cluster ' ' Origin and Structure of the Universe' ' , Garching (Germany); Finocchiaro, P.; Gonzalez-Diaz, D.; Schmah, A. [Laboratori Nazionali del Sud, Istituto Nazionale di Fisica Nucleare, Catania (Italy); Froehlich, I.; Galatyuk, T.; Markert, J.; Muentz, C.; Pachmayer, Y.C.; Pechenova, O.; Pietraszko, J.; Stroebele, H.; Tarantola, A.; Teilab, K. [Goethe-Univ., Inst. fuer Kernphysik, Frankfurt (Germany)] [and others


    We present measurements of exclusive {pi}{sup +,0} and {eta} production in pp reactions at 1.25GeV and 2.2GeV beam kinetic energy in hadron and dielectron channels. In the case of {pi}{sup +} and {pi}{sup 0}, high-statistics invariant-mass and angular distributions are obtained within the HADES acceptance as well as acceptance-corrected distributions, which are compared to a resonance model. The sensitivity of the data to the yield and production angular distribution of {delta} (1232) and higher-lying baryon resonances is shown, and an improved parameterization is proposed. The extracted cross-sections are of special interest in the case of pp{yields}pp{eta}, since controversial data exist at 2.0GeV; we find {sigma}=0.142{+-}0.022 mb. Using the dielectron channels, the {pi}{sup 0} and {eta} Dalitz decay signals are reconstructed with yields fully consistent with the hadronic channels. The electron invariant masses and acceptance-corrected helicity angle distributions are found in good agreement with model predictions. (orig.)

  19. Study of exclusive one-pion and one-eta production using hadron and dielectron channels in pp reactions at kinetic beam energies of 1.25 GeV and 2.2 GeV with HADES

    Agakishiev, G; Balanda, A; Bassini, R; Böhmer, M; Boyard, J L; Cabanelas, P; Chernenko, S; Christ, T; Destefanis, M; Dohrmann, F; Dybczak, A; Eberl, T; Fabbietti, L; Fateev, O; Finocchiaro, P; Friese, J; Fröhlich, I; Galatyuk, T; Garzón, J A; Gernhäuser, R; Gilardi, C; Golubeva, M; González-Díaz, D; Guber, F; Gumberidze, M; Hennino, T; Holzmann, R; Iori, I; Ierusalimov, A; Ivashkin, A; Jurkovic, M; Kämpfer, B; Kanaki, K; Karavicheva, T; Koenig, I; Koenig, W; Kolb, B W; Kotte, R; Kozuch, A; Krizek, F; Kühn, W; Kugler, A; Kurepin, A; Lang, S; Lapidus, K; Liu, T; Maier, L; Markert, J; Metag, V; Michalska, B; Morinière, E; Mousa, J; Müntz, C; Naumann, L; Otwinowski, J; Pachmayer, Y C; Pechenov, V; Pechenova, O; Pietraszko, J; Przygoda, W; Ramstein, B; Reshetin, A; Roy-Stephan, M; Rustamov, A; Sadovsky, A; Sailer, B; Salabura, P; Sánchez, M; Schmah, A; Schwab, E; Sobolev, Yu G; Spataro, S; Spruck, B; Ströbele, H; Stroth, J; Sturm, C; Tarantola, A; Teilab, K; Tlusty, P; Toia, A; Traxler, M; Trebacz, R; Tsertos, H; Wagner, V; Wisniowski, M; Wüstenfeld, J; Yurevich, S; Zanevsky, Y


    We present measurements of exclusive \\pi^{+,0} and \\eta\\ production in pp reactions at 1.25 GeV and 2.2 GeV beam kinetic energy in hadron and dielectron channels. In the case of \\pi^+ and \\pi^0, high-statistics invariant-mass and angular distributions are obtained within the HADES acceptance as well as acceptance corrected distributions, which are compared to a resonance model. The sensitivity of the data to the yield and production angular distribution of \\Delta(1232) and higher lying baryon resonances is shown, and an improved parameterization is proposed. The extracted cross sections are of special interest in the case of pp \\to pp \\eta, since controversial data exist at 2.0 GeV; we find \\sigma =0.142 \\pm 0.022 mb. Using the dielectron channels, the \\pi^0 and \\eta\\ Dalitz decay signals are reconstructed with yields fully consistent with the hadronic channels. The electron invariant masses and acceptance corrected helicity angle distributions are found in good agreement with model predictions.

  20. Cross sections for the formation of 69Znm,g and 71Znm,g in neutron induced reactions near their thresholds: Effect of reaction channel on the isomeric cross-section ratio

    Nesaraja, C. D.; Sudár, S.; Qaim, S. M.


    Excitation functions were measured for the reactions 72Ge(n,α)69Znm,g, 69Ga(n,p)69Znm,g, 70Zn(n,2n)69Znm,g, 74Ge(n,α)71Znm,g, and 71Ga(n,p)71Znm,g over the neutron energy range of 6.3 12.4 MeV. Quasimonoenergetic neutrons in this energy range were produced via the 2H(d,n)3He reaction using a deuterium gas target at the Jülich variable energy compact cyclotron. Use was made of the activation technique in combination with high-resolution HPGe-detector γ-ray spectroscopy. In a few cases low-level β-counting was also applied. In order to decrease the interfering activities in those cases, either radiochemical separations were performed or isotopically enriched targets were used. For most of the reactions, the present measurements provide the first consistent sets of data near their thresholds. From the available experimental data, isomeric cross-section ratios were determined for the isomeric pair 69Znm,g in (n,α), (n,p), and (n,2n) reactions, and for the pair 71Znm,g in (n,α) and (n,p) reactions. Nuclear model calculations using the code STAPRE, which employs the Hauser-Feshbach (statistical model) and exciton model (precompound effects) formalisms, were undertaken to describe the formation of both isomeric and ground states of the products. The calculational results on the total (n,α), (n,p), and (n,2n) cross sections agree fairly well with the experimental data. The experimental isomeric cross-section ratios, however, are reproduced only approximately by the calculation. For both the isomeric pairs investigated, the isomeric cross-section ratio in the (n,p) reaction is higher than in other reactions.

  1. Single-Tube Reaction Using Perfluorocarbons: A Prerequisite Step Leading to the Whole-Slide In Situ Technique on Histopathological Slides.

    Yi-Chang Chen

    Full Text Available Developing a robust, novel method for performing multiple reactions in a single tube is not only time- and cost-saving but also critical for future high-throughput whole-slide in situ techniques on diseased tissues. In this study, we introduce the use of perfluorocarbons and compound-coated magnetic particles to create pseudochambers in a single tube, allowing different reactions to be performed in different phases. Perfluorocarbons also serve as cell lysis buffer and polymerase chain reaction (PCR buffer owing to their highly penetrating, repellent and emulsifiable properties. Using this method, nucleic acids can be isolated and purified from various sample types and sizes, followed by PCR, real-time PCR, or multiplex PCR in the same tube. No incubation or enzyme digesting time is needed and the risk of cross-contamination is reduced. Tests can be performed in microemulsions (water-in-oil droplets containing sequence-specific captures and probes for further high-throughput detection. We present a simple, quick, and robust procedure as a prerequisite step to future high-throughput in situ techniques.

  2. Tissue reactions to bacteria-inoculated rat lead samples .2. Effect of local gentamicin release through surface-modified polyurethane tubing

    vanWachem, PB; vanLuyn, MJA; deWit, AW; Raatjes, D; Hendriks, M; Verhoeven, MLPM; Cahalan, PT


    A surface modification technique was developed to achieve controlled release of gentamicin from implanted polyurethane (PU) rat lead samples. PU tubing first was provided with an acrylic acid/acrylamide copolymer surface graft and then loaded with gentamicin. This surface modification technique resu

  3. Failure of the Standard Coupled-Channels Method in Describing the Inelastic Reaction Data: On the Use of a New Shape for the Coupling Potential

    Erturk, S; Kucuk, Y; Karakoc, M; Aydin, S


    We present the failure of the standard coupled-channels method in explaining the inelastic scattering together with other observables such as elastic scattering, excitation function and fusion data. We use both microscopic double-folding and phenomenological deep potentials with shallow imaginary components. We argue that the solution of the problems for the inelastic scattering data is not related to the central nuclear potential, but to the coupling potential between excited states. We present that these problems can be addressed in a systematic way by using a different shape for the coupling potential instead of the usual one based on Taylor expansion.

  4. How cysteine reacts with citral: an unexpected reaction of beta,beta-disubstituted acroleins with cysteine leading to hexahydro-1,4-thiazepines.

    Starkenmann, Christian; Brauchli, Robert; Maurer, Bruno


    The reaction of beta,beta-disubstituted acroleins [3-methyl-2-butenal (1), 3-methyl-2-hexenal (2), and citral (3)] with cysteine gave 1:2 adducts of a novel structural type, namely hexahydro-1,4-thiazepines. To the best of our knowledge, the spontaneous formation of a seven-membered heterocycle from the addition of cysteine to alpha,beta-unsaturated aldehydes is unprecedented. The adduct 6 obtained from citral, under acidic conditions, reacted further to give the new bicyclic compound 8.

  5. Atypical McMurry Cross-Coupling Reactions Leading to a New Series of Potent Antiproliferative Compounds Bearing the Key [Ferrocenyl-Ene-Phenol] Motif

    Pascal Pigeon; Meral Görmen; Konrad Kowalski; Helge Müller-Bunz; McGlinchey, Michael J.; Siden Top; Gérard Jaouen


    In the course of the preparation of a series of ferrocenyl derivatives of diethylstilbestrol (DES), in which one of the 4-hydroxyphenyl moieties was replaced by a ferrocenyl group, the McMurry reaction of chloropropionylferrocene with a number of mono-aryl ketones unexpectedly yielded the hydroxylated ferrocenyl DES derivatives, 5a–c, in poor yields (10%–16%). These compounds showed high activity on the hormone-independent breast cancer cell line MDA-MB-231 with IC50 values ranging from 0.14 ...

  6. Role of the entrance channel on the product internal energy distribution in the reaction: (Xe-Cl 2) * → XeCl * + Cl

    Boivineau, M.; Le Calvé, J.; Castex, M. C.; Jouvet, C.


    The Xe-Cl 2 van der Waals complex formed in a supersonic expansion is excited by a two-photon process at 297.5 nm. The XeCl ∗ fragment obtained is vibrationally cold. This result is discussed and compared with those of the Xe ∗ + Cl 2 reaction and laser-assisted collision.

  7. On the reaction in the lead-acid battery (as the special review-article by the 2005' Gaston Planté Medal recipient)

    Takehara, Zen-ichiro

    It is my great pleasure to be awarded with the 2005' Gaston Planté Medal for significant contribution to the development of lead-acid battery science and technology. I would like to thank most heartily to Prof. D. Pavlov of Chairman, and all members of the Organic Committee of LABAT'2005 for the best treatment to select me as a 2005' Gaston Planté Medallist.

  8. Photoluminescence and self-assembly of cesium lead halide perovskite nanocrystals: Effects of chain length of organic amines and reaction temperature

    Yuan, Yi; Liu, Zheming; Liu, Zhenyang; Peng, Lan; Li, Yongjie; Tang, Aiwei


    All-inorganic halide perovskites have become one of the most prospective materials for lightening and display technology due to their color-tunable and narrow-band emission. Herein, we have systematically studied the effects of organic amines with different hydrocarbon chain length on the optical properties and morphology as well as the crystal structure of colloidal CsPbBr3 nanocrystals (NCs), which were synthesized in the presence of oleic acid (OA) and organic amines by using a simple hot-injection approach. The hydrocarbon chain length has shown an independent correlation to the morphology and crystal structure of the as-obtained CsPbBr3 NCs at 160 °C, but their optical properties can be affected to some extent. The photoluminescence quantum yields (PLQYs) of the CsPbBr3 NCs synthesized in the presence of organic amines with long carbon chain length are generally in the range of 55-80% for different reaction time, but the PLQYs of less than 20% are obtained for the products synthesized in the presence of octylamine (OTAm) with short carbon chain length. The effects of the reaction temperature on the optical properties, size and crystal structure of the CsPbBr3 NCs synthesized in the presence of cetylamine (CTAm) are studied. Interestingly, some nanoplates also appear in these CsPbBr3 NCs obtained at relatively low temperatures (120 and 140 °C), which have a strong tendency to self-assemble into face-to-face nanostructures. Such a similar self-assembly behavior is also observed in the product synthesized in the presence of oleylamine (OLAm), but only flat nanoplates are observed in the products in the presence of OTAm at 120 °C. The results indicate that the lower reaction temperature and hydrocarbon chain length of the organic ligands play a significant role in the self-assembly of CsPbBr3 NCs. This work opens up an alternative approach to controllable-synthesis of perovskite NCs through varying the carbon chain length of organic surfactants, and enlightens

  9. Oxocentered Cu(II) lead selenite honeycomb lattices hosting Cu(I)Cl2 groups obtained by chemical vapor transport reactions.

    Kovrugin, Vadim M; Colmont, Marie; Siidra, Oleg I; Mentré, Olivier; Al-Shuray, Alexander; Gurzhiy, Vladislav V; Krivovichev, Sergey V


    Chemical vapor transport (CVT) reactions were used to prepare three modular mixed-valent Cu(I)-Cu(II) compounds, (Pb2Cu(2+)9O4)(SeO3)4(Cu(+)Cl(2))Cl5 (1), (PbCu(2+)5O2)(SeO3)2(Cu(+)Cl2)Cl3 (2), and (Pb(x)Cu(2+)(6-x)O2)(SeO3)2(Cu(+)Cl2)K(1-x)Cl(4-x) (x = 0.20) (3). In their crystal structures chains of anion-centered (OCu(2+)4) and (OCu(2+)3Pb) tetrahedra form honeycomb-like double layers with cavities occupied by linear [Cu(+)Cl2](-) groups.

  10. Constraining the equation of state of nuclear matter from competition of fusion and quasi-fission in the reactions leading to production of the superheavy elements

    Veselsky, Martin; Ma, Yu-Gang; Souliotis, Georgios A


    The mechanism of fusion hindrance, an effect preventing the synthesis of superheavy elements in the reactions of cold and hot fusion, is investigated using the Boltzmann-Uehling-Uhlenbeck equation, where Coulomb interaction is introduced. A strong sensitivity is observed both to the modulus of incompressibility of symmetric nuclear matter, controlling the competition of surface tension and Coulomb repulsion, and to the stiffness of the density-dependence of symmetry energy, influencing the formation of the neck prior to scission. The experimental fusion probabilities were for the first time used to derive constraints on the nuclear equation of state. A strict constraint on the modulus of incompressibility of nuclear matter $K_0 = 240 - 260$ MeV is obtained while the stiff density-dependences of the symmetry energy ($\\gamma>1.$) are rejected.

  11. Cross sections for the formation of 69Znm,g and 71Znm,g in neutron induced reactions near their thresholds: Effect of reaction channel on the isomeric cross-section ratio

    Nesaraja, A. N.; Sudár, S.; Qaim, S. M.


    Excitation functions were measured for the reactions Ge-72(n,alpha)Zn-69(m,g), Ga-69(n,p)Zn-69(m,g), Zn-70(n,2n)Zn-69(m,g), Ge-74(n,alpha)Zn-71(m,g), and Ga-71(n,p)Zn-71(m,g) over the neutron energy range of 6.3-12.4 MeV. Quasimonoenergetic neutrons in this energy range were produced via the H-2(d,n)He-3 reaction using a deuterium gas target at the Julich variable energy compact cyclotron. Use was made of the activation technique in combination with high-resolution HPGe-detector gamma-ray spe...

  12. Ca48+Bk249 Fusion Reaction Leading to Element Z =117: Long-Lived α-Decaying Db270 and Discovery of Lr266

    Khuyagbaatar, J.; Yakushev, A.; Düllmann, Ch. E.; Ackermann, D.; Andersson, L.-L.; Asai, M.; Block, M.; Boll, R. A.; Brand, H.; Cox, D. M.; Dasgupta, M.; Derkx, X.; Di Nitto, A.; Eberhardt, K.; Even, J.; Evers, M.; Fahlander, C.; Forsberg, U.; Gates, J. M.; Gharibyan, N.; Golubev, P.; Gregorich, K. E.; Hamilton, J. H.; Hartmann, W.; Herzberg, R.-D.; Heßberger, F. P.; Hinde, D. J.; Hoffmann, J.; Hollinger, R.; Hübner, A.; Jäger, E.; Kindler, B.; Kratz, J. V.; Krier, J.; Kurz, N.; Laatiaoui, M.; Lahiri, S.; Lang, R.; Lommel, B.; Maiti, M.; Miernik, K.; Minami, S.; Mistry, A.; Mokry, C.; Nitsche, H.; Omtvedt, J. P.; Pang, G. K.; Papadakis, P.; Renisch, D.; Roberto, J.; Rudolph, D.; Runke, J.; Rykaczewski, K. P.; Sarmiento, L. G.; Schädel, M.; Schausten, B.; Semchenkov, A.; Shaughnessy, D. A.; Steinegger, P.; Steiner, J.; Tereshatov, E. E.; Thörle-Pospiech, P.; Tinschert, K.; Torres De Heidenreich, T.; Trautmann, N.; Türler, A.; Uusitalo, J.; Ward, D. E.; Wegrzecki, M.; Wiehl, N.; Van Cleve, S. M.; Yakusheva, V.


    The superheavy element with atomic number Z =117 was produced as an evaporation residue in the Ca48+Bk249 fusion reaction at the gas-filled recoil separator TASCA at GSI Darmstadt, Germany. The radioactive decay of evaporation residues and their α-decay products was studied using a detection setup that allowed measuring decays of single atomic nuclei with half-lives between sub-μs and a few days. Two decay chains comprising seven α decays and a spontaneous fission each were identified and are assigned to the isotope 117294 and its decay products. A hitherto unknown α-decay branch in Db270 (Z =105) was observed, which populated the new isotope Lr266 (Z =103). The identification of the long-lived (T1/2=1.0-0.4+1.9 h) α-emitter Db270 marks an important step towards the observation of even more long-lived nuclei of superheavy elements located on an "island of stability."

  13. 48Ca+249Bk fusion reaction leading to element Z = 117: long-lived α-decaying 270Db and discovery of 266Lr.

    Khuyagbaatar, J; Yakushev, A; Düllmann, Ch E; Ackermann, D; Andersson, L-L; Asai, M; Block, M; Boll, R A; Brand, H; Cox, D M; Dasgupta, M; Derkx, X; Di Nitto, A; Eberhardt, K; Even, J; Evers, M; Fahlander, C; Forsberg, U; Gates, J M; Gharibyan, N; Golubev, P; Gregorich, K E; Hamilton, J H; Hartmann, W; Herzberg, R-D; Heßberger, F P; Hinde, D J; Hoffmann, J; Hollinger, R; Hübner, A; Jäger, E; Kindler, B; Kratz, J V; Krier, J; Kurz, N; Laatiaoui, M; Lahiri, S; Lang, R; Lommel, B; Maiti, M; Miernik, K; Minami, S; Mistry, A; Mokry, C; Nitsche, H; Omtvedt, J P; Pang, G K; Papadakis, P; Renisch, D; Roberto, J; Rudolph, D; Runke, J; Rykaczewski, K P; Sarmiento, L G; Schädel, M; Schausten, B; Semchenkov, A; Shaughnessy, D A; Steinegger, P; Steiner, J; Tereshatov, E E; Thörle-Pospiech, P; Tinschert, K; Torres De Heidenreich, T; Trautmann, N; Türler, A; Uusitalo, J; Ward, D E; Wegrzecki, M; Wiehl, N; Van Cleve, S M; Yakusheva, V


    The superheavy element with atomic number Z=117 was produced as an evaporation residue in the (48)Ca+(249)Bk fusion reaction at the gas-filled recoil separator TASCA at GSI Darmstadt, Germany. The radioactive decay of evaporation residues and their α-decay products was studied using a detection setup that allowed measuring decays of single atomic nuclei with half-lives between sub-μs and a few days. Two decay chains comprising seven α decays and a spontaneous fission each were identified and are assigned to the isotope (294)117 and its decay products. A hitherto unknown α-decay branch in (270)Db (Z = 105) was observed, which populated the new isotope (266)Lr (Z = 103). The identification of the long-lived (T(1/2) = 1.0(-0.4)(+1.9) h) α-emitter (270)Db marks an important step towards the observation of even more long-lived nuclei of superheavy elements located on an "island of stability."

  14. Chemistry in Microfluidic Channels

    Chia, Matthew C.; Sweeney, Christina M.; Odom, Teri W.


    General chemistry introduces principles such as acid-base chemistry, mixing, and precipitation that are usually demonstrated in bulk solutions. In this laboratory experiment, we describe how chemical reactions can be performed in a microfluidic channel to show advanced concepts such as laminar fluid flow and controlled precipitation. Three sets of…

  15. Microwave-assisted reaction of peptide formation by amino acid with phosphate: Exploration of the most possible channels for the origin of life

    HU Rong; TIAN Jinping; YIN Yingwu


    Microwave-assisted reaction of peptide formation by amino acids with phosphate was studied. The results showed that the products were a mixture of peptides containing dipeptide, octapeptides and cyclic peptides, which could be obtained in a short time. Polyphosphate was also produced synchronously by the intermolecular condensation of phosphate. The polymerization degree reached 99% (pyrophosphate 64%, trimetaphosphate 35%) after 2 h at 200℃ under microwave irradiation. The intermediates of the mixed anhydrides formed by the intermolecular condensation of phosphates and glycin were determined by ESI-MS. Peptides were also produced by the reaction of amino acids with trimetaphosphate in aqueous solution. The conversion degree of valine reached 46.5% even at room temperature. The cyclic process of peptide formation and phosphate polymerization, regeneration and utilization in amino acids-phosphate system under microwave irradiation was detected and proved. Peptides could be continually formed only by inputting energy into this system. The above recycle may be the most possible process for primitive peptide formation in the origin of life.

  16. Analytical and numerical solution of three-dimensional channel flow in presence of a sinusoidal fluid injection and a chemical reaction

    Sahin Ahmed


    Full Text Available Modeling of three-dimensional channel flow in a chemically-reacting fluid between two long vertical parallel flat plates in the presence of a transverse magnetic field is presented. The stationary plate is subjected to a transverse sinusoidal injection velocity distribution while the uniformly moving plate is subjected to a constant suction and slip boundary conditions. Due to this type of injection velocity, the flow becomes three dimensional. Comparisons with previously published work are performed and the results are found to be in excellent agreement. An increase in the permeability/magnetic parameter is found to escalate the velocity near the plate in motion. Growing Reynolds number or magnetic parameter enhances the x-component and reduces the z-component of the skin-friction at the wall at rest. The acquired knowledge in our study can be used by designers to control MHD flow as suitable for certain applications which include laminar magneto-aerodynamics, materials processing and MHD propulsion thermo-fluid dynamics.

  17. NIF Gamma Reaction History

    Herrmann, H. W.; Kim, Y.; Young, C. S.; Mack, J. M.; McEvoy, A. M.; Hoffman, N. M.; Wilson, D. C.; Langenbrunner, J. R.; Evans, S.; Batha, S. H.; Stoeffl, W.; Lee, A.; Horsfield, C. J.; Rubery, M.; Miller, E. K.; Malone, R. M.; Kaufman, M. I.


    The primary objective of the NIF Gamma Reaction History (GRH) diagnostics is to provide bang time and burn width information based upon measurement of fusion gamma-rays. This is accomplished with energy-thresholded Gas Cherenkov detectors that convert MeV gamma-rays into UV/visible photons for high-bandwidth optical detection. In addition, the GRH detectors can perform γ-ray spectroscopy to explore other nuclear processes from which additional significant implosion parameters may be inferred (e.g., plastic ablator areal density). Implementation is occurring in 2 phases: 1) four PMT-based channels mounted to the outside of the NIF target chamber at ˜6 m from TCC (GRH-6m) for the 3e13-3e16 DT neutron yield range expected during the early ignition-tuning campaigns; and 2) several channels located just inside the target bay shield wall at ˜15 m from TCC (GRH-15m) with optical paths leading through the wall into well-shielded streak cameras and PMTs for the 1e16-1e20 yield range expected during the DT ignition campaign. This suite of diagnostics will allow exploration of interesting γ-ray physics well beyond the ignition campaign. Recent data from OMEGA and NIF will be shown.

  18. RNA Amplification Protocol Leads to Biased Polymerase Chain Reaction Results Especially for Low-Copy Transcripts of Human Bone Marrow-Derived Stromal Cells.

    Carolin Coenen

    Full Text Available The amplification of RNA is becoming increasingly important, as often only limited amounts of cells are available for gene expression analysis. In this study, the gene expression profile of the 39 human homeobox (HOX genes was analyzed in bone marrow-derived multipotent stromal cells (BM-MSCs by reverse transcription (RT- and quantitative polymerase chain reaction (qPCR. For further unlimited gene expression analysis, Whole Transcriptome Amplification (WTA was used to amplify RNA from human BM-MSCs. However, WTA led to biased RT- and qPCR results, and even non-detectability of HOX transcripts compared to non-amplified BM-MSC samples which instead revealed transcription. It is important to note that the same RNA of the respective human BM-MSC line was used for normal cDNA synthesis by standard reverse transcription (non-amplified RT samples and for cDNA synthesis by WTA (amplified WTA samples. On this account, the different RT- and qPCR results were unexpected applying WTA. The significantly reduced detection of HOX transcripts after WTA has been demonstrated for numerous BM-MSC lines (n = 26 by RT-PCR analysis. Furthermore, undetectable HOX transcripts meaning HOX transcripts of human BM-MSCs that were detected after normal cDNA synthesis, but were no longer detectable after WTA, were consistently observed by qPCR analysis. Finally, qPCR experiments revealed a possible explanation for the differences between amplified and non-amplified BM-MSC samples: an inverse correlation between the biased qPCR results and the low expression level of the respective HOX gene. The PCR analysis of high-copy transcripts like GAPDH or RPL13A revealed unchanged qPCR results after WTA compared to corresponding non-amplified BM-MSC samples. In contrast, WTA led to biased qPCR results for medium-copy HOX transcripts, and even non-detectability of low-copy HOX transcripts of human BM-MSCs resulting in false negative RT- and qPCR data applying WTA.

  19. Interference effect between $\\phi$ and $\\Lambda(1520)$ production channels in the $\\gamma p \\rightarrow K^+K^-p$ reaction near threshold

    Ryu, S Y; Nakano, T; Ahn, D S; Ajimura, S; Akimune, H; Asano, Y; Chang, W C; Chen, J Y; Date, S; Ejiri, H; Fujimura, H; Fujiwara, M; Fukui, S; Hasegawa, S; Hicks, K; Horie, K; Hotta, T; Hwang, S H; Imai, K; Ishikawa, T; Iwata, T; Kato, Y; Kawai, H; Kino, K; Kohri, H; Kon, Y; Kumagai, N; Lin, P J; Maeda, Y; Makino, S; Matsuda, T; Matsuoka, N; Mibe, T; Miyabe, M; Miyachi, M; Morino, Y; Muramatsu, N; Murayama, R; Nakatsugawa, Y; Nam, S i; Niiyama, M; Nomachi, M; Ohashi, Y; Ohkuma, H; Ohta, T; Ooba, T; Oshuev, D S; Parker, J D; Rangacharyulu, C; Sakaguchi, A; Sawada, T; Shagin, P M; Shiino, Y; Shimizu, H; Strokovsky, E A; Sugaya, Y; Sumihama, M; Tokiyasu, A O; Toi, Y; Toyokawa, H; Tsunemi, T; Uchida, M; Ungaro, M; Wakai, A; Wang, C W; Wang, S C; Yonehara, K; Yorita, T; Yoshimura, M; Yosoi, M; Zegers, R G T


    The $\\phi$-$\\Lambda(1520)$ interference effect in the $\\gamma p\\to K^+K^-p$ reaction has been measured for the first time in the energy range from 1.673 to 2.173 GeV. The relative phases between $\\phi$ and $\\Lambda(1520)$ production amplitudes were obtained in the kinematic region where the two resonances overlap. The measurement results support strong constructive interference when $K^+K^-$ pairs are observed at forward angles, but destructive interference for proton emission at forward angles. Furthermore, the observed interference effect does not account for the $\\sqrt{s}=2.1$ GeV bump structure in forward differential cross sections for $\\phi$ photoproduction. This fact suggests possible exotic structures such a hidden-strangeness pentaquark state, a new Pomeron exchange and rescattering processes via other hyperon states.

  20. Effect of the bismuth content on the interface reactions between copper substrate and Sn-Zn-Al-Bi lead-free solder

    Soares, D.


    Full Text Available Because of environmental and health concerns, some alternative solder alloys, named lead-free ones, are being developed. Among them, the Sn-Zn-Al system has been studied and reveals promising properties. In this work the presence of bismuth, in the range of 0-8 wt%, was evaluated in what concerns to the chemical interactions between solder/substrate and the equilibrium phases present at the interface. The phases formed at the interface between the copper substrate and a molten lead-free solder were studied with different time of stage and alloy compositions. The effect of bismuth content on transformation temperatures of a Sn-9Zn-1Al base alloy was studied by Differential Scanning Calorimetry (DSC. For each alloy the solidification range was determined, which is an important characteristic regarding the application of these materials in the electronic industry. Identification of equilibrium phases and their chemical composition evaluation was performed by scanning electron microscopy (SEM/EDS. The interface thickness and chemical composition profiles were also evaluated.

    Debido a las preocupaciones ambientales y sanitarias, se están desarrollando aleaciones alternativas para soldadura sin plomo. Entre ellas se ha estudiado el sistema Sn-Zn-Al, que revela propiedades prometedoras. En este trabajo se evalúa la presencia de bismuto, en el rango de 0 a 8 % en peso, en relación con las interacciones químicas entre soldadura y substrato y con las fases de equilibrio presentes en la superficie de contacto. Se han estudiado las fases formadas en la superficie de contacto entre el substrato de cobre y una soldadura fundida sin plomo en función del tiempo de mantenimiento y de la composición de la aleación. Se ha evaluado el efecto del contenido en bismuto sobre las temperaturas de transformación de una aleación de base Sn-9Zn-1Al mediante Calorimetría de Barrido Diferencial (DSC. Se ha determinado el rango de solidificación para cada

  1. 衰老大鼠动脉超微结构及平滑肌钾通道反应性变化%Changes of arterial ultrastructure and reaction of potassium channels in smooth muscle in aged rats

    孙华灵; 石丽君; 李丽; 刘晓东


    BACKGROUND:Potassium channel is the main ion channel to regulate vascular smooth muscle contraction and relaxation, and closely related with vascular tone. However, the reports about the mechanism of potassium channels in the body’s aging process are rare. OBJECTIVE:To investigate the effects of aging on the arterial ultrastructure and smooth muscle potassium channel reaction, and then to explore the possible mechanisms. METHODS:Sixteen healthy male Wistar rats were col ected, 19-month-old rats were assigned to the old group (n=8), 2-month-old rats were used as young group (n=8). The thoracic arteries were isolated and cut into rings to conduct contractility measurement in six rats of each group. The thoracic arteries were stimulated with specific calcium-activated potassium channel blocker tetraethylammonium, specific voltage-dependent potassium channel blocker 4-aminopyridine, specific ATP-sensitive potassium channel blocker glibenclamide, and specific inward rectifier potassium channel blocker BaCl 2 ultrastructure changes under electron microscope. , and then the arterial contractile response to the blockers were observed. The thoracic arteries of the remaining two rats in each group were taken to observe the arterial RESULTS AND CONCLUSION:Compared with the young group, the ultrastructures of the thoracic aortic endothelial cells and smooth muscle cells were changed in the old group;KCI induced the maximum thoracic aortic contractile tension, and then recovered to the baseline tension, and the recovery time in the old group was significantly longer than that in the young group;al the four kinds of blockers could increase vascular tone, and the tetraethylammonium and 4-aminopyridine induced thoracic aortic contractile response in the old group was significantly lower than that in the young group;there was no significant difference in vasoconstriction induced by glibenclamide and BaCl 2 . Aging can induce arterial ultrastructure changes and declination of

  2. High spin spectroscopy near the N=Z line: Channel selection and excitation energy systematics

    Svensson, C.E.; Cameron, J.A.; Flibotte, S. [McMaster Univ., Ontario (Canada)] [and others


    The total {gamma}-ray and charged-particle energies emitted in fusion-evaporation reactions leading to N=Z compound systems in the A = 50-70 mass region have been measured with the 8{pi} {gamma}-ray spectrometer and the miniball charged-particle detector array. A new method of channel selection has been developed which combines particle identification with these total energy measurements and greatly improves upon the selectivity possible with particle detection alone. In addition, the event by event measurement of total {gamma}-ray energies using the BGO ball of the 8{pi} spectrometer has allowed a determination of excitation energies following particle evaporation for a large number of channels in several different reactions. The new channel selection procedure and excitation energy systematics are illustrated with data from the reaction of {sup 24}Mg on {sup 40}Ca at E{sub lab} = 80MeV.

  3. Lead Poisoning

    Lead is a metal that occurs naturally in the earth's crust. Lead can be found in all parts of our ... from human activities such as mining and manufacturing. Lead used to be in paint; older houses may ...

  4. Lead Toxicity

    ... including some imported jewelry. What are the health effects of lead? • More commonly, lower levels of lead in children over time may lead to reduced IQ, slow learning, Attention Deficit Hyperactivity Disorder (ADHD), or behavioral issues. • Lead also affects other ...

  5. Markovian Dynamics on Complex Reaction Networks

    Goutsias, John


    Complex networks, comprised of individual elements that interact with each other through reaction channels, are ubiquitous across many scientific and engineering disciplines. Examples include biochemical, pharmacokinetic, epidemiological, ecological, social, neural, and multi-agent networks. A common approach to modeling such networks is by a master equation that governs the dynamic evolution of the joint probability mass function of the underling population process and naturally leads to Markovian dynamics for such process. Due however to the nonlinear nature of most reactions, the computation and analysis of the resulting stochastic population dynamics is a difficult task. This review article provides a coherent and comprehensive coverage of recently developed approaches and methods to tackle this problem. After reviewing a general framework for modeling Markovian reaction networks and giving specific examples, the authors present numerical and computational techniques capable of evaluating or approximating...

  6. Separable Forces for $(d,p)$ Reactions in Momentum Space

    Hlophe, L; Eremenko, V; Nunes, F M; Thompson, I J; Arbanas, G; Escher, J


    Treating $(d,p)$ reactions in a Faddeev-AGS framework requires the interactions in the sub-systems as input. We derived separable representations for the neutron- and proton-nucleus interactions from phenomenological global optical potentials. In order to take into account excitations of the nucleus, excitations need to be included explicity, leading to a coupled-channel separable representation of the optical potential.

  7. Separable Forces for (d, p Reactions in Momentum Space

    Hlophe L.


    Full Text Available Treating (d, p reactions in a Faddeev-AGS framework requires the interactions in the sub-systems as input. We derived separable representations for the neutron and proton-nucleus interactions from phenomenological global optical potentials. In order to take into account excitations of the nucleus, excitations need to be included explicitly, leading to a coupled-channel separable representation of the optical potential.

  8. Study of 232Th(n, γ) and 232Th(n,f) reaction rates in a graphite moderated spallation neutron field produced by 1.6 GeV deuterons on lead target

    Asquith, N. L.; Hashemi-Nezhad, S. R.; Westmeier, W.; Zhuk, I.; Tyutyunnikov, S.; Adam, J.


    The Gamma-3 assembly of the Joint Institute for Nuclear Research (JINR), Dubna, Russia is designed to emulate the neutron spectrum of a thermal Accelerator Driven System (ADS). It consists of a lead spallation target surrounded by reactor grade graphite. The target was irradiated with 1.6 GeV deuterons from the Nuclotron accelerator and the neutron capture and fission rate of 232Th in several locations within the assembly were experimentally measured. 232Th is a proposed fuel for envisaged Accelerator Driven Systems and these two reactions are fundamental to the performance and feasibility of 232Th in an ADS. The irradiation of the Gamma-3 assembly was also simulated using MCNPX 2.7 with the INCL4 intra-nuclear cascade and ABLA fission/evaporation models. Good agreement between the experimentally measured and calculated reaction rates was found. This serves as a good validation for the computational models and cross section data used to simulate neutron production and transport of spallation neutrons within a thermal ADS.

  9. Lead Poisoning

    ... lead is of microscopic size, invisible to the naked eye. More often than not, children with elevated ... majority of the childhood lead poisoning cases we see today. Children and adults too can get seriously ...

  10. Relational Leading


    This first chapter presents the exploratory and curious approach to leading as relational processes – an approach that pervades the entire book. We explore leading from a perspective that emphasises the unpredictable challenges and triviality of everyday life, which we consider an interesting......, relevant and realistic way to examine leading. The chapter brings up a number of concepts and contexts as formulated by researchers within the field, and in this way seeks to construct a first understanding of relational leading....

  11. Mechanosensitive Channels

    Martinac, Boris

    Living cells are exposed to a variety of mechanical stimuli acting throughout the biosphere. The range of the stimuli extends from thermal molecular agitation to potentially destructive cell swelling caused by osmotic pressure gradients. Cellular membranes present a major target for these stimuli. To detect mechanical forces acting upon them cell membranes are equipped with mechanosensitive (MS) ion channels. Functioning as molecular mechanoelectrical transducers of mechanical forces into electrical and/or chemical intracellular signals these channels play a critical role in the physiology of mechanotransduction. Studies of prokaryotic MS channels and recent work on MS channels of eukaryotes have significantly increased our understanding of their gating mechanism, physiological functions, and evolutionary origins as well as their role in the pathology of disease.

  12. Ion channels-related diseases.

    Dworakowska, B; Dołowy, K


    There are many diseases related to ion channels. Mutations in muscle voltage-gated sodium, potassium, calcium and chloride channels, and acetylcholine-gated channel may lead to such physiological disorders as hyper- and hypokalemic periodic paralysis, myotonias, long QT syndrome, Brugada syndrome, malignant hyperthermia and myasthenia. Neuronal disorders, e.g., epilepsy, episodic ataxia, familial hemiplegic migraine, Lambert-Eaton myasthenic syndrome, Alzheimer's disease, Parkinson's disease, schizophrenia, hyperekplexia may result from dysfunction of voltage-gated sodium, potassium and calcium channels, or acetylcholine- and glycine-gated channels. Some kidney disorders, e.g., Bartter's syndrome, policystic kidney disease and Dent's disease, secretion disorders, e.g., hyperinsulinemic hypoglycemia of infancy and cystic fibrosis, vision disorders, e.g., congenital stationary night blindness and total colour-blindness may also be linked to mutations in ion channels.

  13. Statistical theory of breakup reactions

    Bertulani, Carlos A., E-mail: [Department of Physics and Astronomy, Texas A and M University-Commerce, Commerce, TX (United States); Descouvemont, Pierre, E-mail: [Physique Nucleaire Theorique et Physique Mathematique, Universite Libre de Bruxelles (ULB), Brussels (Belgium); Hussein, Mahir S., E-mail: [Universidade de Sao Paulo (USP), Sao Paulo, SP (Brazil). Instituto de Estudos Avancados


    We propose an alternative for Coupled-Channels calculations with loosely bound exotic nuclei (CDCC), based on the the Random Matrix Model of the statistical theory of nuclear reactions. The coupled channels equations are divided into two sets. The first set, described by the CDCC, and the other set treated with RMT. The resulting theory is a Statistical CDCC (CDCC{sub s}), able in principle to take into account many pseudo channels. (author)

  14. Statistical Theory of Breakup Reactions

    Bertulani Carlos A.


    Full Text Available We propose an alternative for Coupled-Channels calculations with looselybound exotic nuclei(CDCC, based on the the Random Matrix Model of the statistical theory of nuclear reactions. The coupled channels equations are divided into two sets. The first set, described by the CDCC, and the other set treated with RMT. The resulting theory is a Statistical CDCC (CDCCs, able in principle to take into account many pseudo channels.

  15. Statistical Theory of Breakup Reactions

    Bertulani, Carlos A; Hussein, Mahir S


    We propose alternatives to coupled-channels calculations with loosely-bound exotic nuclei (CDCC), based on the the random matrix (RMT) and the optical background (OPM) models for the statistical theory of nuclear reactions. The coupled channels equations are divided into two sets. The first set, described by the CDCC, and the other set treated with RMT. The resulting theory is a Statistical CDCC (CDCC$_S$), able in principle to take into account many pseudo channels.

  16. Statistical Theory of Breakup Reactions

    Bertulani, Carlos A.; Descouvemont, Pierre; Hussein, Mahir S.


    We propose an alternative for Coupled-Channels calculations with looselybound exotic nuclei(CDCC), based on the the Random Matrix Model of the statistical theory of nuclear reactions. The coupled channels equations are divided into two sets. The first set, described by the CDCC, and the other set treated with RMT. The resulting theory is a Statistical CDCC (CDCCs), able in principle to take into account many pseudo channels.

  17. Lead Test

    ... months, and at 3, 4, 5, and 6 years of age. A blood lead level test should be done only if the risk ... recommended if the person is symptomatic at any level below 70 mcg/dL. Because lead will pass through the blood to an unborn child, pregnant ...

  18. Product detection of the CH radical reaction with acetaldehyde.

    Goulay, Fabien; Trevitt, Adam J; Savee, John D; Bouwman, Jordy; Osborn, David L; Taatjes, Craig A; Wilson, Kevin R; Leone, Stephen R


    The reaction of the methylidyne radical (CH) with acetaldehyde (CH(3)CHO) is studied at room temperature and at a pressure of 4 Torr (533.3 Pa) using a multiplexed photoionization mass spectrometer coupled to the tunable vacuum ultraviolet synchrotron radiation of the Advanced Light Source at Lawrence Berkeley National Laboratory. The CH radicals are generated by 248 nm multiphoton photolysis of CHBr(3) and react with acetaldehyde in an excess of helium and nitrogen gas flow. Five reaction exit channels are observed corresponding to elimination of methylene (CH(2)), elimination of a formyl radical (HCO), elimination of carbon monoxide (CO), elimination of a methyl radical (CH(3)), and elimination of a hydrogen atom. Analysis of the photoionization yields versus photon energy for the reaction of CH and CD radicals with acetaldehyde and CH radical with partially deuterated acetaldehyde (CD(3)CHO) provides fine details about the reaction mechanism. The CH(2) elimination channel is found to preferentially form the acetyl radical by removal of the aldehydic hydrogen. The insertion of the CH radical into a C-H bond of the methyl group of acetaldehyde is likely to lead to a C(3)H(5)O reaction intermediate that can isomerize by β-hydrogen transfer of the aldehydic hydrogen atom and dissociate to form acrolein + H or ketene + CH(3), which are observed directly. Cycloaddition of the radical onto the carbonyl group is likely to lead to the formation of the observed products, methylketene, methyleneoxirane, and acrolein.

  19. MEMS in microfluidic channels.

    Ashby, Carol Iris Hill; Okandan, Murat; Michalske, Terry A.; Sounart, Thomas L.; Matzke, Carolyn M.


    Microelectromechanical systems (MEMS) comprise a new class of devices that include various forms of sensors and actuators. Recent studies have shown that microscale cantilever structures are able to detect a wide range of chemicals, biomolecules or even single bacterial cells. In this approach, cantilever deflection replaces optical fluorescence detection thereby eliminating complex chemical tagging steps that are difficult to achieve with chip-based architectures. A key challenge to utilizing this new detection scheme is the incorporation of functionalized MEMS structures within complex microfluidic channel architectures. The ability to accomplish this integration is currently limited by the processing approaches used to seal lids on pre-etched microfluidic channels. This report describes Sandia's first construction of MEMS instrumented microfluidic chips, which were fabricated by combining our leading capabilities in MEMS processing with our low-temperature photolithographic method for fabricating microfluidic channels. We have explored in-situ cantilevers and other similar passive MEMS devices as a new approach to directly sense fluid transport, and have successfully monitored local flow rates and viscosities within microfluidic channels. Actuated MEMS structures have also been incorporated into microfluidic channels, and the electrical requirements for actuation in liquids have been quantified with an elegant theory. Electrostatic actuation in water has been accomplished, and a novel technique for monitoring local electrical conductivities has been invented.

  20. Optimal superdense coding over memory channels

    Shadman, Z.; Kampermann, H.; Bruss, D.; Macchiavello, C. [Institute fuer Theoretische Physik III, Heinrich-Heine-Universitaet Duesseldorf, DE-40225 Duesseldorf (Germany); Dipartimento di Fisica ' ' A. Volta' ' and INFM-Unita di Pavia, Via Bassi 6, IT-27100 Pavia (Italy)


    We study the superdense coding capacity in the presence of quantum channels with correlated noise. We investigate both the cases of unitary and nonunitary encoding. Pauli channels for arbitrary dimensions are treated explicitly. The superdense coding capacity for some special channels and resource states is derived for unitary encoding. We also provide an example of a memory channel where nonunitary encoding leads to an improvement in the superdense coding capacity.

  1. Study on synthesis of new dinuclear copper macrocyclic complex by template reaction involving lead ion as templating agent%模板法合成大环单核铅及双核铜(Ⅱ)配合物

    王小波; 姜治平; 候波涛; 胡学雷; 潘志权


    采用Pb2+作为模板离子,以2,6-二甲酰基对甲苯酚与2-羟基-1,3-丙二胺为原料通过[2+2]缩合反应,得到单核铅配合物[Pb(H2L)](ClO4)2(H2L为中性大环配体),进一步通过金属置换反应合成了一个新的希夫碱大环双核铜(Ⅱ)配合物[Cu2L](ClO4)2,并对中间体大环单核铅配合物及其双核铜(Ⅱ)配合物的结构进行了表征.%A new dinuclear copper macrocyclic complex was synthesized by metal transferred reaction of the mononuclear lead complex as the precursor which was obtained based on the [2+2]condensation between 2,6-diacetyl-4-methylphenol and 1,3-diamino- 2-propanol in the presence of Pb2+ ion.Both structure of two complexes were characterized by several methods.

  2. Development of a chemical kinetic measurement apparatus and the determination of the reaction rate constants for lithium-lead/water interaction. Technical status progress report, October 1, 1991--March 15, 1993

    Biney, P.O.


    An experimental set-up for accurate measurement of hydrogen generation rate in Lithium-Lead (Li{sub 17}Pb{sub 83}) Steam or water interactions has been designed. The most important features of the design include a pneumatic actuated quick opening and closing high temperature all stainless steel valve used to control the reaction time and the placement of most measuring devices below a water line to minimize leakage of the hydrogen collected. A PC based data acquisition and control system provides remote process sequencing, acquisition and control of all major components of the set-up. Initial tests indicate that the first design objective of maintaining leakproof gas collection chamber has been achieved. Initial pressure tests indicated that the pressure drop over a time span of 30 minutes was within the tolerance of the pressure transducer used to measure the pressure (within 0.690 kPa) at a nominal system pressure of 685 kPa. The experimental system hardware, data acquisition and control programs and data analysis program have been completed, tested and are currently functional.

  3. Role of the potential landscape on the single-file diffusion through channels

    Goldt, S. D.; Terentjev, E. M. [Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge CB3 0HE (United Kingdom)


    Transport of colloid particles through narrow channels is ubiquitous in cell biology as well as becoming increasingly important for microfluidic applications or targeted drug delivery. Membrane channels in cells are useful models for artificial designs because of their high efficiency, selectivity, and robustness to external fluctuations. Here, we model the passive channels that let cargo simply diffuse through them, affected by a potential profile along the way. Passive transporters achieve high levels of efficiency and specificity from binding interactions with the cargo inside the channel. This however leads to a paradox: why should channels which are so narrow that they are blocked by their cargo evolve to have binding regions for their cargo if that will effectively block them? Using Brownian dynamics simulations, we show that different potentials, notably symmetric, increase the flux through narrow passive channels – and investigate how shape and depth of potentials influence the flux. We find that there exist optimal depths for certain potential shapes and that it is most efficient to apply a small force over an extended region of the channel. On the other hand, having several spatially discrete binding pockets will not alter the flux significantly. We also explore the role of many-particle effects arising from pairwise particle interactions with their neighbours and demonstrate that the relative changes in flux can be accounted for by the kinetics of the absorption reaction at the end of the channel.

  4. Lead Poisoning

    ... Topics Environment & Health Healthy Living Pollution Reduce, Reuse, Recycle Science – How It Works The Natural World Games ... OTHERS: Lead has recently been found in some plastic mini-blinds and vertical blinds which were made ...

  5. Analysis of transfer reactions: determination of spectroscopic factors

    Keeley, N. [CEA Saclay, Dept. d' Astrophysique, de Physique des Particules de Physique Nucleaire et de l' Instrumentation Associee (DSM/DAPNIA/SPhN), 91- Gif sur Yvette (France); The Andrzej So an Institute for Nuclear Studies, Dept. of Nuclear Reactions, Warsaw (Poland)


    An overview of the most popular models used for the analysis of direct reaction data is given, concentrating on practical aspects. The 4 following models (in order of increasing sophistication): the distorted wave born approximation (DWBA), the adiabatic model, the coupled channels born approximation, and the coupled reaction channels are briefly described. As a concrete example, the C{sup 12}(d,p)C{sup 13} reaction at an incident deuteron energy of 30 MeV is analysed with progressively more physically sophisticated models. The effect of the choice of the reaction model on the spectroscopic information extracted from the data is investigated and other sources of uncertainty in the derived spectroscopic factors are discussed. We have showed that the choice of the reaction model can significantly influence the nuclear structure information, particularly the spectroscopic factors or amplitudes but occasionally also the spin-parity, that we wish to extract from direct reaction data. We have also demonstrated that the DWBA can fail to give a satisfactory description of transfer data but when the tenets of the theory are fulfilled DWBA can work very well and will yield the same results as most sophisticated models. The use of global rather than fitted optical potentials can also lead to important differences in the extracted spectroscopic factors.

  6. Positron Channeling

    Badikyan, Karen


    The possibility of channeling the low-energy relativistic positrons around separate crystallographic axes with coaxial symmetry of negative ions in some types of crystals is shown. The process of annihilation of positrons with electrons of medium was studied in detail.

  7. Brands & Channels

    Alice Yang


    @@ "Brands" and "Channels" are the two most important things in Ku-Hai Chen's eyes when doing business with Main-land China. Ku-Hai Chen, Executive Director of the International Trade Institute of Taiwan External Trade Development Council (TAITRA), flies frequently between Chinese Taipei and Mainland China, and was in Beijing earlier this month for his seminar.

  8. Can erosion control structures in large dryland arroyo channels lead to resilient riparian and cienega restoration? Observations from LiDAR, monitoring and modeling at Rancho San Bernardino, Sonora, MX

    DeLong, S.; Henderson, W. M.


    The use of erosion control structures to mitigate or even reverse erosion and to restore ecological function along dryland channels (arroyos and gullies) has led to a long list of both successful and failed restoration efforts. We propose that successful implementation of "engineering" approaches to fluvial restoration that include in-channel control structures require either a quantitative approach to design (by scientists and engineers), or intimate on-the-ground knowledge, local observation, and a commitment to adapt and maintain restoration efforts in response to landscape change (by local land managers), or both. We further propose that the biophysical interactions among engineering, sedimentation, flood hydrology and vegetation reestablishment are what determine resilience to destructive extreme events that commonly cause erosion control structure failure. Our insights come from comprehensive monitoring of a remarkable experiment underway at Ranch San Bernardino, Sonora, MX. At this site, private landowners are working to restore ecosystem function to riparian corridors and former cieñega wetlands using cessation of grazing; vegetation planting; upland grass restoration; large scale rock gabions (up to 100 m wide) to encourage local sediment deposition and water storage; and large earthen berms (up to 900 m wide) with cement spillways that form reservoirs that fill rapidly with water and sediment. Well-planned and managed erosion control structures have been used elsewhere successfully in smaller gully networks, but we are unaware of a comparable attempt to use gabions and berms for the sole purpose of ecological restoration along >10 km of arroyo channels draining watersheds on the order of ~400 km2 and larger. We present an approach to monitoring the efficacy of arroyo channel restoration using terrestrial and airborne LiDAR, remote sensing, streamflow monitoring, shallow groundwater monitoring, hydrological modeling and field observation. Our methods

  9. Geometric phase effects in ultracold hydrogen exchange reaction

    Hazra, Jisha; Kendrick, Brian K.; Balakrishnan, N.


    The role of the geometric phase effect on chemical reaction dynamics is explored by examining the hydrogen exchange process in the fundamental H+HD reaction. Results are presented for vibrationally excited HD molecules in the v = 4 vibrational level and for collision energies ranging from 1 μK to 100 K. It is found that, for collision energies below 3 K, inclusion of the geometric phase leads to dramatic enhancement or suppression of the reaction rates depending on the final quantum state of the HD molecule. The effect was found to be the most prominent for rotationally resolved integral and differential cross sections but it persists to a lesser extent in the vibrationally resolved and total reaction rate coefficients. However, no significant GP effect is present in the reactive channel leading to the D+H2 product or in the D+H2 (v=4,j=0) \\to HD+H reaction. A simple interference mechanism involving inelastic (nonreactive) and exchange scattering amplitudes is invoked to account for the observed GP effects. The computed results also reveal a shape resonance in the H+HD reaction near 1 K and the GP effect is found to influence the magnitude of the resonant part of the cross section. Experimental detection of the resonance may allow a sensitive probe of the GP effect in the H+HD reaction.

  10. Channel Power in Multi-Channel Environments

    M.G. Dekimpe (Marnik); B. Skiera (Bernd)


    textabstractIn the literature, little attention has been paid to instances where companies add an Internet channel to their direct channel portfolio. However, actively managing multiple sales channels requires knowing the customers’ channel preferences and the resulting channel power. Two key compon

  11. Channel Power in Multi-Channel Environments

    M.G. Dekimpe (Marnik); B. Skiera (Bernd)


    textabstractIn the literature, little attention has been paid to instances where companies add an Internet channel to their direct channel portfolio. However, actively managing multiple sales channels requires knowing the customers’ channel preferences and the resulting channel power. Two key

  12. Dissociation of relativistic projectiles with the continuum-discretized coupled-channels method

    Ogata, K


    Relativistic effects in the breakup of weakly-bound nuclei at intermediate energies are studied and compared with non-relativistic calculations. We show that relativistic corrections lead to larger breakup cross sections. Since many of these reactions can only be treated correctly if one accounts for the coupling between states in the continuum, we show that continuum-discretized coupled-channels calculations are also be strongly influenced by relativistic effects.

  13. Ecotoxicology: Lead

    Scheuhammer, A.M.; Beyer, W.N.; Schmitt, C.J.; Jorgensen, Sven Erik; Fath, Brian D.


    Lead (Pb) is a naturally occurring metallic element; trace concentrations are found in all environmental media and in all living things. However, certain human activities, especially base metal mining and smelting; combustion of leaded gasoline; the use of Pb in hunting, target shooting, and recreational angling; the use of Pb-based paints; and the uncontrolled disposal of Pb-containing products such as old vehicle batteries and electronic devices have resulted in increased environmental levels of Pb, and have created risks for Pb exposure and toxicity in invertebrates, fish, and wildlife in some ecosystems.

  14. Multi-channel gas-delivery system

    Rozenzon, Yan; Trujillo, Robert T.; Beese, Steven C.


    One embodiment of the present invention provides a gas-delivery system for delivering reaction gas to a reactor chamber. The gas-delivery system includes a main gas-inlet port for receiving reaction gases and a gas-delivery plate that includes a plurality of gas channels. A gas channel includes a plurality of gas holes for allowing the reaction gases to enter the reactor chamber from the gas channel. The gas-delivery system further includes a plurality of sub-gas lines coupling together the main gas-inlet port and the gas-delivery plate, and a respective sub-gas line is configured to deliver a portion of the received reaction gases to a corresponding gas channel.

  15. Theoretical studies of the reactions of O(3p) with halogenated methyl (Ⅰ)——Reaction mechanism of the O(3p) + CH2Cl reaction

    侯华; 王宝山; 顾月姝


    The reaction of O(3P) with CH2Cl radical has been studied using ab initio molecular orbital theory. G2 (MP2) method is used to calculate the geometrical parameters, vibrational frequencies and energies of various stationary points on the potential energy surface. The reaction mechanism is revealed. The addition of O(3P) with CH2Cl leads to the formation of an energy rich intermediate OCH2Cl which can subsequently undergo decomposition or isomerization to the final products. The calculated heat of reaction for each channel is in agreement with the experimental value. The production of H+CHClO and Cl+CH2O are predicted to be the major channels. The overall rate constants are calculated using transition state theory on the basis of ab initio data. The rate constant is pressure independent and exhibits negative temperature dependence at lower temperatures, in accordance with the experimental results.

  16. Leading men

    Bekker-Nielsen, Tønnes


    Through a systematic comparison of c. 50 careers leading to the koinarchate or high priesthood of Asia, Bithynia, Galatia, Lycia, Macedonia and coastal Pontus, as described in funeral or honorary inscriptions of individual koinarchs, it is possible to identify common denominators but also...

  17. Lead grids


    One of the 150 lead grids used in the multiwire proportional chamber g-ray detector. The 0.75 mm diameter holes are spaced 1 mm centre to centre. The grids were made by chemical cutting techniques in the Godet Workshop of the SB Physics.

  18. Chemical burn or reaction

    ... this page: // Chemical burn or reaction To use the sharing features on this page, please enable JavaScript. Chemicals that touch skin can lead to a reaction on the skin, throughout the body, or both. ...

  19. Nonlinear channelizer

    In, Visarath; Longhini, Patrick; Kho, Andy; Neff, Joseph D.; Leung, Daniel; Liu, Norman; Meadows, Brian K.; Gordon, Frank; Bulsara, Adi R.; Palacios, Antonio


    The nonlinear channelizer is an integrated circuit made up of large parallel arrays of analog nonlinear oscillators, which, collectively, serve as a broad-spectrum analyzer with the ability to receive complex signals containing multiple frequencies and instantaneously lock-on or respond to a received signal in a few oscillation cycles. The concept is based on the generation of internal oscillations in coupled nonlinear systems that do not normally oscillate in the absence of coupling. In particular, the system consists of unidirectionally coupled bistable nonlinear elements, where the frequency and other dynamical characteristics of the emergent oscillations depend on the system's internal parameters and the received signal. These properties and characteristics are being employed to develop a system capable of locking onto any arbitrary input radio frequency signal. The system is efficient by eliminating the need for high-speed, high-accuracy analog-to-digital converters, and compact by making use of nonlinear coupled systems to act as a channelizer (frequency binning and channeling), a low noise amplifier, and a frequency down-converter in a single step which, in turn, will reduce the size, weight, power, and cost of the entire communication system. This paper covers the theory, numerical simulations, and some engineering details that validate the concept at the frequency band of 1-4 GHz.

  20. Products of the Benzene + O(3P) Reaction

    Taatjes, Craig A.; Osborn, David L.; Selby, Talitha M.; Meloni, Giovanni; Trevitt, Adam J.; Epifanovsky, Evgeny; Krylov, Anna I.; Sirjean, Baptiste; Dames, Enoch; Wang, Hai


    The gas-phase reaction of benzene with O(3P) is of considerable interest for modeling of aromatic oxidation, and also because there exist fundamental questions concerning the prominence of intersystem crossing in the reaction. While its overall rate constant has been studied extensively, there are still significant uncertainties in the product distribution. The reaction proceeds mainly through the addition of the O atom to benzene, forming an initial triplet diradical adduct, which can either dissociate to form the phenoxy radical and H atom, or undergo intersystem crossing onto a singlet surface, followed by a multiplicity of internal isomerizations, leading to several possible reaction products. In this work, we examined the product branching ratios of the reaction between benzene and O(3P) over the temperature range of 300 to 1000 K and pressure range of 1 to 10 Torr. The reactions were initiated by pulsed-laser photolysis of NO2 in the presence of benzene and helium buffer in a slow-flow reactor, and reaction products were identified by using the multiplexed chemical kinetics photoionization mass spectrometer operating at the Advanced Light Source (ALS) of Lawrence Berkeley National Laboratory. Phenol and phenoxy radical were detected and quantified. Cyclopentadiene and cyclopentadienyl radical were directly identified for the first time. Finally, ab initio calculations and master equation/RRKM modeling were used to reproduce the experimental branching ratios, yielding pressure-dependent rate expressions for the reaction channels, including phenoxy + H, phenol, cyclopentadiene + CO, which are proposed for kinetic modeling of benzene oxidation.

  1. Who Leads China's Leading Universities?

    Huang, Futao


    This study attempts to identify the major characteristics of two different groups of institutional leaders in China's leading universities. The study begins with a review of relevant literature and theory. Then, there is a brief introduction to the selection of party secretaries, deputy secretaries, presidents and vice presidents in leading…

  2. Theoretical study of effects of the entrance channel on the relative yield of complete fusion and quasifission in heavy-ion collisions within a dinuclear system approach

    Soheyli, S.; Khanlari, M. Varasteh


    The relative yield of complete fusion and quasifission components for the 12C+204Pb , 19F+197Au , 30Si+186W , and 48Ca+168Er reactions which all lead to the compound nucleus 216Ra are analyzed to calculate the entrance channel effects by comparison of capture, complete fusion, and quasifission cross sections, emission barriers (Bfus*,Bq f ), as well as complete fusion probability estimated by statistical method within the framework of the dinuclear system model. The difference among complete fusion probabilities calculated by the dinuclear system model for different entrance channels can be explained by the hindrance to complete fusion due to the larger inner fusion barrier Bfus* for the transformation of the dinuclear system into a compound nucleus and the increase of the quasifission contribution due to the decreasing of the emission barrier Bq f of quasifission as a function of the angular momentum. Although these reactions with different entrance channels populate the same compound nucleus 216Ra at similar excitation energies, the model predicts the negligible quasifission probability for reactions having higher entrance channel mass asymmetry and the dominant decay channel is complete fission. For reactions induced by massive projectiles such as Si and Ca having lower entrance channel mass asymmetry, the quasifission component is dominant in the evolution of dinuclear system, and the fusion process is extremely hindered.

  3. Leading Cities

    Pogner, Karl-Heinz


    and technical engineering; Smart Cities) is very prominent in the traditional mass media discourse, in PR / PA of tech companies and traditional municipal administrations; whereas the second one (participation; Livable Cities) is mostly enacted in social media, (local) initiatives, movements, (virtual......) communities, new forms of urban governance in municipal administration and co-competitive city networks. Both forms seem to struggle for getting voice and power in the discourses, negotiations, struggles, and conflicts in Urban Governance about the question how to manage or lead (in) a city. Talking about...

  4. Dynamic Reaction Mechanisms of ClO(-) with CH3Cl: Comparison Between Direct Dynamics Trajectory Simulations and Experiment.

    Yu, Feng


    We have investigated the dynamic reaction mechanisms of *ClO¯ with CH3Cl (the asterisk is utilized to label a different Cl atom). Ab initio molecular dynamics simulations at the MP2/6-31+G(d,p) level of theory have been employed to compute the dynamic trajectories. On the basis of our simulations, the dynamic reaction pathways for the bimolecular nucleophilic substitution (SN2) reaction channel and SN2-induced elimination reaction channel are clearly illustrated. For the SN2 reaction channel, some trajectories directly dissociate to the final products of CH3O*Cl and Cl¯, whereas the others involve the dynamic Cl¯···CH3O*Cl intermediate complex. As to the SN2-induced elimination reaction channel, the trajectories lead to the final products of CH2O, HCl, and *Cl¯ through the dynamic Cl¯···CH3O*Cl intermediate complex. More significantly, the product branching ratios of Cl¯ and *Cl¯ predicted by our simulations are basically consistent with previous experimental results (Villano et al. J. Am. Chem. Soc. 2009, 131, 8227-8233).

  5. Measurement of double differential cross sections for light charged particles production in neutron induced reaction at 62.7 MeV on lead target; Mesures des sections efficaces doublement differentielles de production de particules chargees legeres lors de reactions induites par neutrons de 62.7 MeV sur cible de plomb

    Kerveno, M


    In order to develop new options for nuclear waste management, studies are carrying out on the perfecting of hybrid systems (sub-critical reactor driven by accelerator). This thesis work takes place more precisely in the framework of nuclear data linked to hybrid systems development. Increasing the upper limit energy value (from 20 to 150 MeV) of data bases supposes that theoretical codes could have sufficient predictive power in this energy range. Thus it's necessary to measure new cross sections to constrain these codes. The experiment, performed at Louvain-la-Neuve Cyclotron, aims to determine the double differential cross sections for light charged particles production in neutron induced reactions at 62.7 MeV on natural lead target. The detection device consists of 6 NE102-CsI telescopes. Time of flight measurements are used to reconstruct the neutron energy spectra. The general framework (hybrid systems and associated nuclear data problematic) in which this work takes place is presented in a first part. The experimental set up used for our measurements is described in a second part. The three following parts are dedicated to the data analysis and double differential cross sections extraction. The particle discrimination, the energy calibration of detectors as the different corrections applied to the experimental spectra are related in details. And finally a comparative study between our experimental results and some theoretical predictions is presented. (author)

  6. Markovian dynamics on complex reaction networks

    Goutsias, J., E-mail:; Jenkinson, G., E-mail:


    Complex networks, comprised of individual elements that interact with each other through reaction channels, are ubiquitous across many scientific and engineering disciplines. Examples include biochemical, pharmacokinetic, epidemiological, ecological, social, neural, and multi-agent networks. A common approach to modeling such networks is by a master equation that governs the dynamic evolution of the joint probability mass function of the underlying population process and naturally leads to Markovian dynamics for such process. Due however to the nonlinear nature of most reactions and the large size of the underlying state-spaces, computation and analysis of the resulting stochastic population dynamics is a difficult task. This review article provides a coherent and comprehensive coverage of recently developed approaches and methods to tackle this problem. After reviewing a general framework for modeling Markovian reaction networks and giving specific examples, the authors present numerical and computational techniques capable of evaluating or approximating the solution of the master equation, discuss a recently developed approach for studying the stationary behavior of Markovian reaction networks using a potential energy landscape perspective, and provide an introduction to the emerging theory of thermodynamic analysis of such networks. Three representative problems of opinion formation, transcription regulation, and neural network dynamics are used as illustrative examples.

  7. Eye Injuries from Pencil Lead: Three Cases

    Ceyhun Arici; Osman Sevki Arslan; Burcu Görgülü; Rengin Yildirim; Umut Onur


      Corneal stromal and/or penetrating ocular injuries from pencils and pencil lead are more common in childhood and may lead to intraocular infection or severe intraocular sterile inflammatory reaction...

  8. Eye Injuries from Pencil Lead: Three Cases

    Ceyhun Arıcı; Osman Şevki Arslan; Burcu Görgülü; Rengin Yıldırım; Umut Onur


    Corneal stromal and/or penetrating ocular injuries from pencils and pencil lead are more common in childhood and may lead to intraocular infection or severe intraocular sterile inflammatory reaction...

  9. Marine Toxins Targeting Ion Channels

    Hugo R. Arias


    Full Text Available Abstract: This introductory minireview points out the importance of ion channels for cell communication. The basic concepts on the structure and function of ion channels triggered by membrane voltage changes, the so-called voltage-gated ion channels (VGICs, as well as those activated by neurotransmitters, the so-called ligand-gated ion channel (LGICs, are introduced. Among the most important VGIC superfamiles, we can name the voltage-gated Na+ (NaV, Ca2+ (CaV, and K+ (KV channels. Among the most important LGIC super families, we can include the Cys-loop or nicotinicoid, the glutamate-activated (GluR, and the ATP-activated (P2XnR receptor superfamilies. Ion channels are transmembrane proteins that allow the passage of different ions in a specific or unspecific manner. For instance, the activation of NaV, CaV, or KV channels opens a pore that is specific for Na+, Ca2+, or K+, respectively. On the other hand, the activation of certain LGICs such as nicotinic acetylcholine receptors, GluRs, and P2XnRs allows the passage of cations (e.g., Na+, K+, and/or Ca2+, whereas the activation of other LGICs such as type A γ-butyric acid and glycine receptors allows the passage of anions (e.g., Cl− and/or HCO3−. In this regard, the activation of NaV and CaV as well as ligand-gated cation channels produce membrane depolarization, which finally leads to stimulatory effects in the cell, whereas the activation of KV as well as ligand-gated anion channels induce membrane hyperpolarization that finally leads to inhibitory effects in the cell. The importance of these ion channel superfamilies is emphasized by considering their physiological functions throughout the body as well as their pathophysiological implicance in several neuronal diseases. In this regard, natural molecules, and especially marine toxins, can be potentially used as modulators (e.g., inhibitors or prolongers of ion channel functions to treat or to alleviate a specific

  10. Numerical investigation on detonation cell evolution in a channel with area-changing cross section

    DENG; Bo


    The two-dimensional cellular detonation propagating in a channel with area- changing cross section was numerically simulated with the dispersion-controlled dissipative scheme and a detailed chemical reaction model. Effects of the flow expansion and compression on the cellular detonation cell were investigated to illustrate the mechanism of the transverse wave development and the cellular detonation cell evolution. By examining gas composition variations behind the leading shock, the chemical reaction rate, the reaction zone length, and thermodynamic parameters, two kinds of the abnormal detonation waves were identified. To explore their development mechanism, chemical reactions, reflected shocks and rarefaction waves were discussed, which interact with each other and affect the cellular detonation in different ways.  ……

  11. Numerical investigation on detonation cell evolution in a channel with area-changing cross section


    @@ The two-dimensional cellular detonation propagating in a channel with area- changing cross section was numerically simulated with the dispersion-controlled dissipative scheme and a detailed chemical reaction model. Effects of the flow expansion and compression on the cellular detonation cell were investigated to illustrate the mechanism of the transverse wave development and the cellular detonation cell evolution. By examining gas composition variations behind the leading shock, the chemical reaction rate, the reaction zone length, and thermodynamic parameters, two kinds of the abnormal detonation waves were identified. To explore their development mechanism, chemical reactions, reflected shocks and rarefaction waves were discussed, which interact with each other and affect the cellular detonation in different ways.


    Balderas, E; Arteaga-Tlecuitl, R; Rivera, M; Gomora, JC; Darszon, A.


    Voltage-dependent calcium channels are widely distributed in animal cells, including spermatozoa. Calcium is fundamental in many sperm functions such as: motility, capacitation and the acrosome reaction, all essential for fertilization. Pharmacological evidence has suggested T-type calcium channels participate in the acrosome reaction. Niflumic acid (NA), a non-steroidal anti-inflammatory drug commonly used as chloride channel blocker, blocks T-currents in mouse spermatogenic cells and Cl− ch...

  13. Kinetics and Product Channels in Combustion Chemistry

    Hershberger, John F. [North Dakota State Univ., Fargo, ND (United States)


    We report study of the chemical kinetics and/or photochemistry of several chemical reactions of potential interest in understanding the gas phase combustion chemistry of nitrogen-containing molecules. Studies completed during the final grant period include determination of quantum yields of the photolysis of HCNO, fulminic acid, a kinetics and product channel study of the reaction of CN radicals with methyl bromide, and study of the products of the reaction of hydroxymethyl radical with nitric oxide.

  14. Local Transfer Coefficient, Smooth Channel

    R. T. Kukreja


    Full Text Available Naphthalene sublimation technique and the heat/mass transfer analogy are used to determine the detailed local heat/mass transfer distributions on the leading and trailing walls of a twopass square channel with smooth walls that rotates about a perpendicular axis. Since the variation of density is small in the flow through the channel, buoyancy effect is negligible. Results show that, in both the stationary and rotating channel cases, very large spanwise variations of the mass transfer exist in he turn and in the region immediately downstream of the turn in the second straight pass. In the first straight pass, the rotation-induced Coriolis forces reduce the mass transfer on the leading wall and increase the mass transfer on the trailing wall. In the turn, rotation significantly increases the mass transfer on the leading wall, especially in the upstream half of the turn. Rotation also increases the mass transfer on the trailing wall, more in the downstream half of the turn than in the upstream half of the turn. Immediately downstream of the turn, rotation causes the mass transfer to be much higher on the trailing wall near the downstream corner of the tip of the inner wall than on the opposite leading wall. The mass transfer in the second pass is higher on the leading wall than on the trailing wall. A slower flow causes higher mass transfer enhancement in the turn on both the leading and trailing walls.

  15. The development of a chemical kinetic measurement apparatus and the determination of the reaction rate constants for lithium-lead/steam interaction. Final report 9-21-90--3-31-95

    Biney, P.O.


    The objective of this research to experimentally determine the hydrogen generation rate during the beginning and subsequent stages of liquid metal (Li{sub 17}Pb{sub 83}) and water reaction. The experimental set-up has been built. It includes a metal sample preparation apparatus, a reaction system, a measurement system and a PC based data acquisition and control system. The most important feature of the reaction system is a pneumatic actuated quick opening and closing high temperature, all stainless steel valve used the system for reaction time control. The PC system provides remote process sequencing, acquisition and control of all the systems except the metal preparation apparatus. Due to the reactivity of the lithium, all the metal sampling, preparation and loading procedures are executed in a glove box under argon protection. The metal temperature was varied between 350{degrees}C-650{degrees}C and water temperature fixed at 60{degrees}C during the experiments. A set of experimental procedures and two analyses methods: (1) thermodynamics method and (2) heat transfer method are discussed. All the measurements and data collections are executed under the PC system control. A data analysis program is used to calculate both the partial pressure of hydrogen and the hydrogen generation rate. The experiment results indicate that the amount of hydrogen generated is relate to the initial liquid metal temperature when the reaction surface is fixed. The mass of hydrogen generated as a function of initial liquid metal temperature and time of reaction is presented, The hydrogen generation over a time period of 240 seconds and the calculated errors are summarized in Table 1.

  16. Effects of the next-to-leading order terms in the chiral SU(3) Lagrangian on the strangeness -1 s-wave meson-baryon interactions

    Magas, V K; Ramos, A


    The meson-baryon interactions in s-wave in the strangeness S=-1 sector are studied using a chiral unitarity approach based on the next-to-leading order chiral SU(3) Lagrangian. The model is fitted to the large set of experimental data in different two-body channels. Particular attention is paid to the $\\Xi$ hyperon production reaction, $\\bar{K} N \\rightarrow K \\Xi$, where the effect of the next-to-leading order terms in the Lagrangian play a crucial role, since the cross section of this reaction at tree level is zero.

  17. Peptide bond formation through gas-phase reactions in the interstellar medium: formamide and acetamide as prototypes

    Redondo, Pilar; Barrientos, Carmen; Largo, Antonio, E-mail: [Computational Chemistry Group, Departamento de Química Física, Facultad de Ciencias, Universidad de Valladolid, E-47011 Valladolid (Spain)


    A theoretical study of the reactions of NH{sub 4}{sup +} with formaldehyde and CH{sub 5}{sup +} with formamide is carried out. The viability of these gas-phase ion-molecule reactions as possible sources of formamide and acetamide under the conditions of interstellar medium is evaluated. We report a theoretical estimation of the reaction enthalpies and an analysis of their potential energy surfaces. Formation of protonated formamide from the reaction between ammonium cation and formaldehyde is an exothermic process, but all the channels located on the potential energy surface leading to this product present net activation energies. For the reaction between methanium and formamide, different products are possible from a thermodynamic point of view. An analysis of its potential energy surface showed that formation of protonated acetamide and amino acetaldehyde takes place through barrier-free paths. Therefore, this reaction could be a feasible source of acetamide and amino acetaldehyde in space.

  18. Nanoparticle Reactions on Chip

    Köhler, J. M.; Kirner, Th.; Wagner, J.; Csáki, A.; Möller, R.; Fritzsche, W.

    The handling of heterogenous systems in micro reactors is difficult due to their adhesion and transport behaviour. Therefore, the formation of precipitates and gas bubbles has to be avoided in micro reaction technology, in most cases. But, micro channels and other micro reactors offer interesting possibilities for the control of reaction conditions and transport by diffusion and convection due to the laminar flow caused by small Reynolds numbers. This can be used for the preparation and modification of objects, which are much smaller than the cross section of microchannels. The formation of colloidal solutions and the change of surface states of nano particles are two important tasks for the application of chip reactors in nanoparticle technology. Some concepts for the preparation and reaction of nanoparticles in modular chip reactor arrangements will be discussed.

  19. Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels.

    Jang, Hyunbum; Arce, Fernando Teran; Capone, Ricardo; Ramachandran, Srinivasan; Lal, Ratnesh; Nussinov, Ruth


    In Alzheimer's disease, calcium permeability through cellular membranes appears to underlie neuronal cell death. It is increasingly accepted that calcium permeability involves toxic ion channels. We modeled Alzheimer's disease ion channels of different sizes (12-mer to 36-mer) in the lipid bilayer using molecular dynamics simulations. Our Abeta channels consist of the solid-state NMR-based U-shaped beta-strand-turn-beta-strand motif. In the simulations we obtain ion-permeable channels whose subunit morphologies and shapes are consistent with electron microscopy/atomic force microscopy. In agreement with imaged channels, the simulations indicate that beta-sheet channels break into loosely associated mobile beta-sheet subunits. The preferred channel sizes (16- to 24-mer) are compatible with electron microscopy/atomic force microscopy-derived dimensions. Mobile subunits were also observed for beta-sheet channels formed by cytolytic PG-1 beta-hairpins. The emerging picture from our large-scale simulations is that toxic ion channels formed by beta-sheets spontaneously break into loosely interacting dynamic units that associate and dissociate leading to toxic ionic flux. This sharply contrasts intact conventional gated ion channels that consist of tightly interacting alpha-helices that robustly prevent ion leakage, rather than hydrogen-bonded beta-strands. The simulations suggest why conventional gated channels evolved to consist of interacting alpha-helices rather than hydrogen-bonded beta-strands that tend to break in fluidic bilayers. Nature designs folded channels but not misfolded toxic channels.

  20. Measurements of gas and volatile element production rates from an irradiated molten lead and lead-bismuth spallation target with proton beams of 1 and 1.4 GeV; Mesures de taux de production d'elements gazeux et volatiles lors de reactions induites par des protons de 1 et 1,4 GeV sur des cibles epaisses de plomb et plomb-bismuth liquides

    Tall, Y


    The integrated project EUROTRANS (European Research Programme for the Transmutation of High Level Nuclear Waste in an Accelerator Driven System) of the 6. EURATOM Framework Programme aims to demonstrate the transmutation of radioactive waste in ADS (Accelerator Driven Sub-critical system). It will carry out a first advanced design of an experimental facility to demonstrate the technical feasibility of transmutation, and will produce a conceptual design of an industrial facility dedicated to transmutation. An ADS consists of three fundamental elements: the accelerator of protons, the sub-critical core and the spallation target. SUBATECH (physique Sub-Atomique et des Technologies associees) laboratory is involved to the study of the chosen liquid lead-bismuth as a spallation ADS target. The irradiation of liquid lead-bismuth target with energetic proton beam generates in addition to neutrons, volatile and radioactive residues. In order to determine experimentally the production rates of gas and volatile elements following a spallation reaction in a lead-bismuth target, the experiment IS419 was performed at the ISOLDE facility at CERN (Centre Europeen de la Recherche Nucleaire). This experiment constitutes the frame of the thesis whose main objective is to assess and study the production and release rates of many gas and volatile element from the irradiated lead-bismuth target with an energetic proton beam. The obtained data are compared to Monte Carlo simulation code (MCNPX) results in order to test the intranuclear cascade model of Bertini and of Cugnon, and the evaporation options of Dresner and Schmidt. (author)

  1. ICF gamma-ray reaction history diagnostics

    Herrmann, H. W.; Young, C. S.; Mack, J. M.; Kim, Y. H.; McEvoy, A.; Evans, S.; Sedillo, T.; Batha, S.; Schmitt, M.; Wilson, D. C.; Langenbrunner, J. R.; Malone, R.; Kaufman, M. I.; Cox, B. C.; Frogget, B.; Miller, E. K.; Ali, Z. A.; Tunnell, T. W.; Stoeffl, W.; Horsfield, C. J.; Rubery, M.


    Reaction history measurements, such as nuclear bang time and burn width, are fundamental components of diagnosing ICF implosions and will be employed to help steer the National Ignition Facility (NIF) towards ignition. Fusion gammas provide a direct measure of nuclear interaction rate (unlike x-rays) without being compromised by Doppler spreading (unlike neutrons). Gas Cherenkov Detectors that convert fusion gamma rays to UV/visible Cherenkov photons for collection by fast optical recording systems have established their usefulness in illuminating ICF physics in several experimental campaigns at OMEGA. In particular, bang time precision better than 25 ps has been demonstrated, well below the 50 ps accuracy requirement defined by the NIF. NIF Gamma Reaction History (GRH) diagnostics are being developed based on optimization of sensitivity, bandwidth, dynamic range, cost, and NIF-specific logistics, requirements and extreme radiation environment. Implementation will occur in two phases. The first phase consists of four channels mounted to the outside of the target chamber at ~6 m from target chamber center (GRH-6m) coupled to ultra-fast photo-multiplier tubes (PMT). This system is intended to operate in the 1013-1017 neutron yield range expected during the early THD campaign. It will have high enough bandwidth to provide accurate bang times and burn widths for the expected THD reaction histories (> 80 ps fwhm). Successful operation of the first GRH-6m channel has been demonstrated at OMEGA, allowing a verification of instrument sensitivity, timing and EMI/background suppression. The second phase will consist of several channels located just inside the target bay shield wall at 15 m from target chamber center (GRH-15m) with optical paths leading through the cement shield wall to well-shielded streak cameras and PMTs. This system is intended to operate in the 1016-1020 yield range expected during the DT ignition campaign, providing higher temporal resolution for the

  2. Does the ion-molecule reaction between HC tbnd CH rad + and HCN lead to CH 2dbnd CH-C tbnd N rad + ? A computational and experimental study of the reverse process

    Jobst, Karl J.; Hasan, Syed A.; Terlouw, Johan K.


    The title ion-molecule reaction has been proposed to play an important role in interstellar chemistry if it yields acrylonitrile ions CH 2dbnd CH-C tbnd N rad + . This question was probed by examining the formation of HC tbnd CH rad + and HCN from low-energy ions CH 2dbnd CH-C tbnd N rad + and related isomers, using tandem mass spectrometry based experiments (D and 13C labelling) in conjunction with model chemistry calculations (CBS-QB3/APNO). We conclude that the title reaction is a barrierless multistep rearrangement that may not effectively compete with the straightforward formation of stable distonic ions HC dbnd CH-N dbnd CH rad + from HC tbnd CH rad + (ion)-HCN(dipole) encounter complexes.

  3. Ab initio Mechanism Study on the Reaction of Chlorine Atom with Formic Acid

    于海涛; 付宏刚; 等


    The potential energy surface(PES) for the reaction of Cl atom with HCOOH is predicted using ab initio molecular orbital calculation methods at UQCIDS(T,full)6-311++G(3df,2p)//UMP2(full)/6-311+G(d,P) level of theory with zero-point vibrational energy (ZPVE) correction.The calculated results show that the reaction mechanism of Cl atom with formic acid is a C-site hydrogen abstraction reaction from cis-HOC(H)O molecule by Cl atom with a 3.73kJ/mol reaction barrier height,leading to the formation of cis-HOCO radical which will reacts with Cl atom or other molecules in such a reaction system.Because the reaction barrier height of O-site hydrogen abstraction reaction from cis-HOC(H)O molecule by Cl atom which leads to the formation of HCO2 radical is 67.95kJ/mol,it is a secondary reaction channel in experiment,This is in good agreement with the prediction based on the previous experiments.

  4. Reaction of Np atom with H₂O in the gas phase: reaction mechanisms and ab initio molecular dynamics study.

    Li, Peng; Niu, Wenxia; Gao, Tao; Wang, Hongyan


    The gas-phase reaction of an Np atom with H2O was investigated using density functional theory and ab initio molecular dynamics. The reaction mechanisms and the corresponding potential energy profiles for different possible spin states were analyzed. Three reaction channels were found in the mechanism study: the isomerization channel, the H2 elimination channel, and the H atom elimination channel. The latter two were observed in the dynamics simulation. It was found that the branching ratio of the title reaction depends on the initial kinetic energy along the transition vector. Product energy distributions for the reaction were evaluated by performing direct classical trajectory calculations on the lowest sextet potential energy surface. The results indicate that most of the available energy appears as the translational energy of the products. The overall results indicate that the H2 elimination channel with low kinetic energy is thermodynamically favored but competes with the H atom elimination channel with higher kinetic energy.

  5. Eikonal reaction theory for two-neutron removal reactions

    Minomo, K; Egashira, K; Ogata, K; Yahiro, M


    The eikonal reaction theory (ERT) proposed lately is a method of calculating one-neutron removal reactions at intermediate incident energies in which Coulomb breakup is treated accurately with the continuum discretized coupled-channels method. ERT is extended to two-neutron removal reactions. ERT reproduces measured one- and two-neutron removal cross sections for 6He scattering on 12C and 208Pb targets at 240 MeV/nucleon and also on a 28Si target at 52 MeV/nucleon. For the heavier target in which Coulomb breakup is important, ERT yields much better agreement with the measured cross sections than the Glauber model.

  6. Characterization of the Minimum Energy Paths and Energetics for the reaction of Vinylidene with Acetylene

    Walch, Stephen P.; Taylor, Peter R.


    The reaction of vinylidene (CH2C) with acetylene may be an initiating reaction in soot formation. We report minimum energy paths and accurate energetics for a pathway leading to vinylacetylene and for a number of isomers Of C4H4. The calculations use complete active space self-consistent field (CASSCF) derivative methods to characterize the stationary points and internally contacted configuration interaction (ICCI) and/or coupled cluster singles and doubles with a perturbational estimate of triple excitations (CCSD(T)) to determine the energetics. We find an entrance channel barrier of about 5 kcal/mol for the addition of vinylidene to acetylene, but no barriers above reactants for the reaction pathway leading to vinylacetylene.

  7. Investigation of the Poisoning Mechanism of Lead on the CeO2-WO3 Catalyst for the NH3-SCR Reaction via in Situ IR and Raman Spectroscopy Measurement.

    Peng, Yue; Si, Wenzhe; Li, Xiang; Chen, Jianjun; Li, Junhua; Crittenden, John; Hao, Jiming


    The in situ IR and Raman spectroscopy measurements were conducted to investigate lead poisoning on the CeO2-WO3 catalysts. The deactivation mechanisms were studied with respect to the changes of surface acidity, redox property, nitrate/nitrite adsorption behaviors, and key active sites (note that the results of structure-activity relationship of CeO2-WO3 were based on our previous research). (1) Lewis acid sites originated from CeO2 and crystalline WO3, whereas Brønsted acid sites originated from Ce2(WO4)3. The poisoned catalysts exhibited a lower surface acidity than the fresh catalysts: the number of acid sites decreased, and their thermal stability weakened. (2) The reducibility of catalysts and the amount of active oxygen exhibited a smaller influence after poisoning because lead preferred to bond with surface WOx species rather than CeO2. (3) The quantity of active nitrate species decreased due to the lead coverage on the catalyst and the partial bridged-nitrate species induced by lead exhibited a low degree of activity at 200 °C. (4) Crystalline WO3 and Ce2(WO4)3 originated from the transformation of polytungstate sites. These sites were the key active sites during the SCR process. The formation temperatures of polytungstate on the poisoned catalysts were higher than those on the fresh catalysts.

  8. Capacity of Sparse Wideband Channels with Partial Channel Feedback

    Hariharan, Gautham; Sayeed, Akbar M


    This paper studies the ergodic capacity of wideband multipath channels with limited feedback. Our work builds on recent results that have established the possibility of significant capacity gains in the wideband/low-SNR regime when there is perfect channel state information (CSI) at the transmitter. Furthermore, the perfect CSI benchmark gain can be obtained with the feedback of just one bit per channel coefficient. However, the input signals used in these methods are peaky, that is, they have a large peak-to-average power ratios. Signal peakiness is related to channel coherence and many recent measurement campaigns show that, in contrast to previous assumptions, wideband channels exhibit a sparse multipath structure that naturally leads to coherence in time and frequency. In this work, we first show that even an instantaneous power constraint is sufficient to achieve the benchmark gain when perfect CSI is available at the receiver. In the more realistic non-coherent setting, we study the performance of a tra...

  9. Reaction Graph



    The paper proposes reaction graphs as graphical representations of computational objects.A reaction graph is a directed graph with all its arrows and some of its nodes labeled.Computations are modled by graph rewriting of a simple nature.The basic rewriting rules embody the essence of both the communications among processes and cut-eliminations in proofs.Calculi of graphs are ideentified to give a formal and algebraic account of reaction graphs in the spirit of process algebra.With the help of the calculi,it is demonstrated that reaction graphs capture many interesting aspects of computations.

  10. Mobile radio channels

    Pätzold, Matthias


    Providing a comprehensive overview of the modelling, analysis and simulation of mobile radio channels, this book gives a detailed understanding of fundamental issues and examines state-of-the-art techniques in mobile radio channel modelling. It analyses several mobile fading channels, including terrestrial and satellite flat-fading channels, various types of wideband channels and advanced MIMO channels, providing a fundamental understanding of the issues currently being investigated in the field. Important classes of narrowband, wideband, and space-time wireless channels are explored in deta

  11. Theoretical study of the reactions M(+)+CH(3)F (M=Ge, As, Se, Sb).

    Méndez, Oscar; Colmenares, Fernando


    CASSCF-MRMP2 calculations have been carried out to analyze the reactions of the methyl fluoride molecule with the atomic ions Ge(+), As(+), Se(+) and Sb(+). For these interactions, potential energy curves for the low-lying electronic states were calculated for different approaching modes of the fragments. Particularly, those channels leading to C-H and C--F oxidative addition products, H(2)FC-M-H(+) and H(3)C-M-F(+), respectively were explored, as well as the paths which evolve to the abstraction (M-F(+)+CH(3)) and the elimination (CH(2)M(+)+HF) asymptotes. For the reaction Ge(+)+CH(3)F the only favorable channel leads to fluorine abstraction by the ion. As(+) and Sb(+) can react with CH(3)F along pathways yielding stable addition products. However, a viable path joining the oxidative addition product H(3)C-M-F(+) with the elimination asymptote CH(2)M(+)+HF was found for the reaction of the fluorocarbon compound with As(+). No favorable channels were detected for the interaction of fluoromethane with Se(+). The results discussed herein allow rationalizing some of the experimental data found for these interactions through gas-phase mass spectrometry.

  12. Investigation of the quasifission process by theoretical analysis of experimental data of fissionlike reaction products

    Giardina, G; Mandaglio, G; Curciarello, F; De Leo, V; Fazio, G; Manganaro, M; Romaniuk, M; Saccá, C; 10.1088/1742-6596/282/1/012006


    The fusion excitation function is the important quantity in planning experiments for the synthesis of superheavy elements. Its values seem to be determined by the experimental study of the hindrance to complete fusion by the observation of mass, angular and energy distributions of the fissionlike fragments. There is ambiguity in establishment of the reaction mechanism leading to the observed binary fissionlike fragments. The fissionlike fragments can be produced in the quasifission, fast fission, and fusion-fission processes which have overlapping in the mass (angular, kinetic energy) distributions of fragments. The branching ratio between quasifission and complete fusion strongly depends on the characteristics of the entrance channel. In this paper we consider a wide set of reactions (with different mass asymmetry and mass symmetry parameters) with the aim to explain the role played by many quantities on the reaction mechanisms. We also present the results of study of the $^{48}$Ca+$^{249}$Bk reaction used t...

  13. Averaging methods for stochastic dynamics of complex reaction networks: description of multi-scale couplings

    Plyasunov, S


    This paper is concerned with classes of models of stochastic reaction dynamics with time-scales separation. We demonstrate that the existence of the time-scale separation naturally leads to the application of the averaging principle and elimination of degrees of freedom via the renormalization of transition rates of slow reactions. The method suggested in this work is more general than other approaches presented previously: it is not limited to a particular type of stochastic processes and can be applied to different types of processes describing fast dynamics, and also provides crossover to the case when separation of time scales is not well pronounced. We derive a family of exact fluctuation-dissipation relations which establish the connection between effective rates and the statistics of the reaction events in fast reaction channels. An illustration of the technique is provided. Examples show that renormalized transition rates exhibit in general non-exponential relaxation behavior with a broad range of pos...

  14. Enzymatic Reactions in Microfluidic Devices

    Ristenpart, W. D.; Wan, J.; Stone, H. A.


    We establish simple scaling laws for enzymatic reactions in microfluidic devices, and we demonstrate that kinetic parameters obtained conventionally using multiple stop-flow experiments may instead be extracted from a single microfluidic experiment. Introduction of an enzyme and substrate species in different arms of a Y-shaped channel allows the two species to diffuse across the parallel streamlines and to begin reacting. Measurements of the product concentration versus distance down the channel provide information about the kinetics of the reaction. In the limit where the enzyme is much larger (and thus less diffusive) than the substrate, we show that near the entrance the total amount of product (P) formed varies as a power law in the distance x down the channel. For reactions that follow standard Michaelis-Menten kinetics, the power law takes the form P˜(Vmax/Km) x^5/2, where Vmax and Km are the maximum reaction rate and Michaelis constant respectively. If a large excess of substrate is used, then Km is identified by measuring Vmax far downstream where the different species are completely mixed by diffusion. Numerical simulations and experiments using the bioluminescent reaction between luciferase and ATP as a model system are both shown to accord with the model. We discuss the implications for significant savings in the amount of time and enzyme required for determination of kinetic parameters.

  15. Channel nut tool

    Olson, Marvin


    A method, system, and apparatus for installing channel nuts includes a shank, a handle formed on a first end of a shank, and an end piece with a threaded shaft configured to receive a channel nut formed on the second end of the shaft. The tool can be used to insert or remove a channel nut in a channel framing system and then removed from the channel nut.

  16. Improved catalytic performance of Ni catalysts for steam methane reforming in a micro-channel reactor

    Bozhao Chu; Nian Zhang; Xuli Zhai; Xin Chen; Yi Cheng


    Milliseconds process to produce hydrogen by steam methane reforming (SMR) reaction, based on Ni catalyst rather than noble catalyst such as Pd, Rh or Ru, in micro-channel reactors has been paid more and more attentions in recent years. This work aimed to further improve the catalytic performance of nickel-based catalyst by the introduction of additives, i.e., MgO and FeO, prepared by impregnation method on the micro-channels made of metal-ceramic complex substrate. The prepared catalysts were tested in the same micro-channel reactor by switching the catalyst plates. The results showed that among the tested catalysts Ni-Mg catalyst had the highest activity, especially under harsh conditions, i.e., at high space velocity and/or low reaction temperature. Moreover, the catalyst activity and selectivity were stable during the 12 h on stream test even when the ratio of steam to carbon (S/C) was as low as 1.0. The addition of MgO promoted the active Ni species to have a good dispersion on the substrate, leading to a better catalytic performance for SMR reaction.

  17. Feshbach resonances in the exit channel of the F + CH3OH → HF + CH3O reaction observed using transition-state spectroscopy

    Weichman, Marissa L.; Devine, Jessalyn A.; Babin, Mark C.; Li, Jun; Guo, Lifen; Ma, Jianyi; Guo, Hua; Neumark, Daniel M.


    The transition state governs how chemical bonds form and cleave during a chemical reaction and its direct characterization is a long-standing challenge in physical chemistry. Transition state spectroscopy experiments based on negative-ion photodetachment provide a direct probe of the vibrational structure and metastable resonances that are characteristic of the reactive surface. Dynamical resonances are extremely sensitive to the topography of the reactive surface and provide an exceptional point of comparison with theory. Here we study the seven-atom F + CH3OH → HF + CH3O reaction using slow photoelectron velocity-map imaging spectroscopy of cryocooled CH3OHF‑ anions. These measurements reveal spectral features associated with a manifold of vibrational Feshbach resonances and bound states supported by the post-transition state potential well. Quantum dynamical calculations yield excellent agreement with the experimental results, allow the assignment of spectral structure and demonstrate that the key dynamics of complex bimolecular reactions can be captured with a relatively simple theoretical framework.

  18. Influence of swelling on reaction efficiency in intercalated clay minerals. 2. Pillared clays

    Politowicz, P.A.; San Leung, L.B.; Kozak, J.J. (Australian National Univ., Canberra)


    Methods for intercalating thermally stable, polynuclear hydroxy metal cations and/or metal cluster cations in smectite clays have been developed in recent years as a means of keeping separate the silicate layers in the absence of a swelling solvent. Since the pillaring cations are space filling, the interlamellar reaction space will be broken up into an interconnected set of channels through which a diffusing species can migrate. In this paper, a lattice model is designed to determine how different spatial distributions of pillaring agents and different interlamellar spacings can influence the efficiency of reaction between a fixed target molecule and a diffusing coreactant. The authors study two regular distributions of pillaring cations and calculate the mean reaction time (as calibrated by the mean walklength ) of the diffusing coreactant as a function of the separation between silicate layers. All other factors being held constant, they find a significant increase in the reaction efficiency with increase in the number of channels available to the coreactant. They also find that for each distribution there is a decrease in reaction efficiency as one increases the interlayer spacing, with the surprising result that for large arrays the addition of one or two layers above the basal plane (where the target molecule is anchored at the centrosymmetric site) leads to essentially the same relative changes in the reaction efficiency regardless of the spatial distribution considered.

  19. Intravenous Metronidazole after Drinking Leads to a Report of 1 Cases of Disulfiram Like Reaction%静滴甲硝唑后饮酒致双硫仑样反应1例

    王永啟; 张群柱


    Objective To strengthen the response due to metronidazole cure acute pericoronitis and specific measures to deal with alcohol cause disulfiram-like reaction. Methods Given oxygen, promethazine 25mg intramuscular injection, 5% dextrose 1000ml + Vitamin C 200mg + Vitamin B6 200mg +10% potassium chloride 10ml intravenously. Results After intravenous administration three hours of headache, dizziness, palpitations, chest tightness, shortness of breath, irritability, vomiting symptoms disappeared. Conclusion Disulfiram-like reaction during most of the patients after discontinuation of medication or alcohol-induced 5-7 days, severe clinical manifestations, and easily misdiagnosed. For patients and their families to clearly inform the application within 10 days after the period of withdrawal-related drugs and alcohol and alcoholic beverages is prohibited in order to avoid adverse reactions or serious consequences.%目的:加强应对因甲硝唑治愈急性智齿冠周炎后饮酒造成双硫仑样反应的应对及具体措施。方法给予吸氧,异丙嗪25mg肌内注射,5%葡萄糖1000ml+维生素C 200mg+维生素B6200mg+10%氯化钾10ml静脉滴注。结果静脉滴注用药3h后头痛、头晕、心悸、胸闷、气短、烦躁,呕吐症状基本消失。结论双硫仑样反应多数是在患者用药期间或停药后5~7d内饮酒诱发,对患者及其家属要明确告知在应用相关药物期间及停药后10d内禁止饮酒及含酒饮品,以免引起不良反应甚至严重后果。

  20. Microscopic effective reaction theory for deuteron-induced reactions

    Neoh, Yuen Sim; Minomo, Kosho; Ogata, Kazuyuki


    The microscopic effective reaction theory is applied to deuteron-induced reactions. A reaction model-space characterized by a $p+n+{\\rm A}$ three-body model is adopted, where A is the target nucleus, and the nucleon-target potential is described by a microscopic folding model based on an effective nucleon-nucleon interaction in nuclear medium and a one-body nuclear density of A. The three-body scattering wave function in the model space is obtained with the continuum-discretized coupled-channels method (CDCC), and the eikonal reaction theory (ERT), an extension of CDCC, is applied to the calculation of neutron removal cross sections. Elastic scattering cross sections of deuteron on $^{58}$Ni and $^{208}$Pb target nuclei at several energies are compared with experimental data. The total reaction cross sections and the neutron removal cross sections at 56 MeV on 14 target nuclei are calculated and compared with experimental values.

  1. Microscopic effective reaction theory for deuteron-induced reactions

    Neoh, Yuen Sim; Yoshida, Kazuki; Minomo, Kosho; Ogata, Kazuyuki


    The microscopic effective reaction theory is applied to deuteron-induced reactions. A reaction model space characterized by a p +n +A three-body model is adopted, where A is the target nucleus, and the nucleon-target potential is described by a microscopic folding model based on an effective nucleon-nucleon interaction in nuclear medium and a one-body nuclear density of A . The three-body scattering wave function in the model space is obtained with the continuum-discretized coupled-channels (CDCC) method, and the eikonal reaction theory (ERT), an extension of CDCC, is applied to the calculation of neutron removal cross sections. Elastic scattering cross sections of deuteron on 58Ni and 208Pb target nuclei at several energies are compared with experimental data. The total reaction cross sections and the neutron removal cross sections at 56 MeV on 14 target nuclei are calculated and compared with experimental values.

  2. Response reactions: equilibrium coupling.

    Hoffmann, Eufrozina A; Nagypal, Istvan


    It is pointed out and illustrated in the present paper that if a homogeneous multiple equilibrium system containing k components and q species is composed of the reactants actually taken and their reactions contain only k + 1 species, then we have a unique representation with (q - k) stoichiometrically independent reactions (SIRs). We define these as coupling reactions. All the other possible combinations with k + 1 species are the coupled reactions that are in equilibrium when the (q - k) SIRs are in equilibrium. The response of the equilibrium state for perturbation is determined by the coupling and coupled equilibria. Depending on the circumstances and the actual thermodynamic data, the effect of coupled equilibria may overtake the effect of the coupling ones, leading to phenomena that are in apparent contradiction with Le Chatelier's principle.

  3. Laser photochemical lead isotopes separation for harmless nuclear power engineering

    Bokhan, P. A.; Fateev, N. V.; Kim, V. A.; Zakrevsky, D. E.


    The collisional quenching of the metastable 3 P 1,2 and 1 D 2 lead atoms is studied experimentally in the gas flow of the lead atoms, reagent-molecules and a carrier gas Ar. The experimental parameters were similar to the conditions that are required in the operation of the experimental setup for photochemical isotope separation. Excited atoms are generated under electron impact conditions created by a gas glow discharge through the mixture of gases and monitored photoelectrically by attenuation of atomic resonance radiation from hollow cathode 208Pb lamp. The decay of the excited atoms has been studied in the presence various molecules and total cross section data are reported. The flow tube measurements has allowed to separate the physical and chemical quenching channels and measure the rates of the chemical reaction excited lead with N2O, CH2Cl2, SF6 and CuBr molecules. These results are discussed in the prospects of the obtaining isotopically modified lead as a promising coolant in the reactors on the fast-neutron.

  4. Reaction cross-section predictions for nucleon induced reactions

    Nobre, G P A; Escher, J E; Dietrich, F S


    A microscopic calculation of the optical potential for nucleon-nucleus scattering has been performed by explicitly coupling the elastic channel to all the particle-hole (p-h) excitation states in the target and to all relevant pickup channels. These p-h states may be regarded as doorway states through which the flux flows to more complicated configurations, and to long-lived compound nucleus resonances. We calculated the reaction cross sections for the nucleon induced reactions on the targets $^{40,48}$Ca, $^{58}$Ni, $^{90}$Zr and $^{144}$Sm using the QRPA description of target excitations, coupling to all inelastic open channels, and coupling to all transfer channels corresponding to the formation of a deuteron. The results of such calculations were compared to predictions of a well-established optical potential and with experimental data, reaching very good agreement. The inclusion of couplings to pickup channels were an important contribution to the absorption. For the first time, calculations of excitatio...

  5. Liquid drop effects in subbarrier transfer reactions

    Kim, H.J.


    Reaction products from a multitude of binary channels are observed to emerge at large c.m. angles at subbarrier energies for the {sup 50}Ti {plus} {sup 93}Nb system. The energy spectra of these products and the distance where they first emerge indicate that these reaction products result from the neck which is formed outside the Coulomb barrier. 9 refs., 5 figs.

  6. Multi-Channel Retailing

    Dirk Morschett, Dr.,


    Full Text Available Multi-channel retailing entails the parallel use by retailing enterprises of several sales channels. The results of an online buyer survey which has been conducted to investigate the impact of multi-channel retailing (i.e. the use of several retail channels by one retail company on consumer behaviour show that the frequently expressed concern that the application of multi-channel systems in retailing would be associated with cannibalization effects, has proven unfounded. Indeed, the appropriate degree of similarity, consistency, integration and agreement achieves the exact opposite. Different channels create different advantages for consumers. Therefore the total benefit an enterprise which has a multi-channel system can offer to its consumers is larger, the greater the number of available channels. The use of multi-channel systems is associated with additional purchases in the different channels. Such systems are thus superior to those offering only one sales channel to their customers. Furthermore, multi-channel systems with integrated channels are superior to those in which the channels are essentially autonomous and independent of one another. In integrated systems, consumers can achieve synergy effects in the use of sales-channel systems. Accordingly, when appropriately formulated, multi-channel systems in retailing impact positively on consumers. They use the channels more frequently, buy more from them and there is a positive customer-loyalty impact. Multi-channel systems are strategic options for achieving customer loyalty, exploiting customer potential and for winning new customers. They are thus well suited for approaching differing and varied target groups.

  7. Hadamard quantum broadcast channels

    Wang, Qingle; Das, Siddhartha; Wilde, Mark M.


    We consider three different communication tasks for quantum broadcast channels, and we determine the capacity region of a Hadamard broadcast channel for these various tasks. We define a Hadamard broadcast channel to be such that the channel from the sender to one of the receivers is entanglement-breaking and the channel from the sender to the other receiver is complementary to this one. As such, this channel is a quantum generalization of a degraded broadcast channel, which is well known in classical information theory. The first communication task we consider is classical communication to both receivers, the second is quantum communication to the stronger receiver and classical communication to other, and the third is entanglement-assisted classical communication to the stronger receiver and unassisted classical communication to the other. The structure of a Hadamard broadcast channel plays a critical role in our analysis: The channel to the weaker receiver can be simulated by performing a measurement channel on the stronger receiver's system, followed by a preparation channel. As such, we can incorporate the classical output of the measurement channel as an auxiliary variable and solve all three of the above capacities for Hadamard broadcast channels, in this way avoiding known difficulties associated with quantum auxiliary variables.

  8. Ion channels regulating mast cell biology.

    Ashmole, I; Bradding, P


    Mast cells play a central role in the pathophysiology of asthma and related allergic conditions. Mast cell activation leads to the degranulation of preformed mediators such as histamine and the secretion of newly synthesised proinflammatory mediators such as leukotrienes and cytokines. Excess release of these mediators contributes to allergic disease states. An influx of extracellular Ca2+ is essential for mast cell mediator release. From the Ca2+ channels that mediate this influx, to the K+ , Cl- and transient receptor potential channels that set the cell membrane potential and regulate Ca2+ influx, ion channels play a critical role in mast cell biology. In this review we provide an overview of our current knowledge of ion channel expression and function in mast cells with an emphasis on how channels interact to regulate Ca2+ signalling.

  9. Channel incision and water quality

    Shields, F. D.


    Watershed development often triggers channel incision that leads to radical changes in channel morphology. Although morphologic evolution due to channel incision has been documented and modeled by others, ecological effects, particularly water quality effects, are less well understood. Furthermore, environmental regulatory frameworks for streams frequently focus on stream water quality and underemphasize hydrologic and geomorphic issues. Discharge, basic physical parameters, solids, nutrients (nitrogen and phosphorus), chlorophyll and bacteria were monitored for five years at two sites along a stream in a mixed cover watershed characterized by rapid incision of the entire channel network. Concurrent data were collected from two sites on a nearby stream draining a watershed of similar size and cultivation intensity, but without widespread incision. Data sets describing physical aquatic habitat and fish fauna of each stream were available from other studies. The second stream was impacted by watershed urbanization, but was not incised, so normal channel-floodplain interaction maintained a buffer zone of floodplain wetlands between the study reach and the urban development upstream. The incised stream had mean channel depth and width that were 1.8 and 3.5 times as large as for the nonincised stream, and was characterized by flashier hydrology. The median rise rate for the incised stream was 6.4 times as great as for the nonincised stream. Correlation analyses showed that hydrologic perturbations were associated with water quality degradation, and the incised stream had levels of turbidity and solids that were two to three times higher than the nonincised, urbanizing stream. Total phosphorus, total Kjeldahl N, and chlorophyll a concentrations were significantly higher in the incised stream, while nitrate was significantly greater in the nonincised, urbanizing stream (p Ecological engineering of stream corridors must focus at least as much energy on mediating hydrologic

  10. General characteristics of exclusive annihilation channels in anti pp interactions at 32 GeV/c

    Proskuryakov, A.S.; Murzin, V.S.; Sarycheva, L.I. (Moskovskij Gosudarstvennyj Univ. (USSR). Nauchno-Issledovatel' skij Inst. Yadernoj Fiziki)


    For the purpose of investigating the kinematic characteristics of exclusive reactions in anti pp-interactions the experiment has been performed with the bubble chamber ''Mirabelle'' irradiated in 32.1 GeV/c antiproton beam. Cross sections are obtained of multiparticle (nsub(+-) >= 6) annihilation channels with charged (4c-fit) as well as with charged and one neutral (1c-fit) pions in the final state. The basic characteristics of pion emission are studied. The leading effect manifested by the annihilation pions is revealed.

  11. Predissociation of methyl cyanoformate: The HCN and HNC channels

    Wilhelm, Michael J; González-Vázquez, Jesús; Vázquez, Saulo A; Smith, Jonathan M; Dai, Hai-Lung


    We present a combined experimental and theoretical investigation of the 193 nm photolysis of the cyano-ester, methyl cyanoformate (MCF). Specifically, nanosecond time-resolved infrared emission spectroscopy was used to monitor the ro-vibrationally excited photoproducts generated in the photolysis reaction. The signal-to-noise of all time-resolved spectra were enhanced using the recently developed algorithm, spectral reconstruction analysis, which allowed observation of previously obscured minor resonances, and revealed new dissociation channels producing HCN and HNC. Spectral fit analysis of the nascent HCN and electronically excited CN($A^2\\Pi_1$) resonances yield a lower bound estimate for the HCN quantum yield of ca. 0.42$\\pm$0.24%. Multi-configuration self-consistent field calculations were used to interrogate the ground and four lowest energy singlet excited states of MCF. At 193 nm, dissociation is predicted to occur predominantly on the repulsive S$_2$ state. Nevertheless, minor pathways leading to the...

  12. USACE Navigation Channels 2012

    California Department of Resources — This dataset represents both San Francisco and Los Angeles District navigation channel lines. All San Francisco District channel lines were digitized from CAD files...

  13. Channelling versus inversion

    Gale, A.S.; Surlyk, Finn; Anderskouv, Kresten


    . Within this channel were smaller erosional structures (hardgrounds, and locally have a basal fill of granular phosphorite. The entire channel system was progressively infilled by chalk, as demonstrated by the expanded succession...

  14. Charged particle sub-barrier transfer reactions for {sup 16}O + {sup A}Sm and their influence on the fusion cross section

    Gomes, P.R.S.; Maciel, A.M.M.; Cabezas, R. [and others


    Transfer cross section angular distribution data for the stripping of two protons and one alpha particle are studied for the {sup 16}O + {sup A}Sm systems (A = 144, 148, 150, 152 and 154), at energies slightly lower than the Coulomb barriers and angles up to 0 = 170{degrees}. From a semiclassical formalism, transfer and elastic scattering data, the transfer form factors is derived. For only one of the ten channels studied there are signatures for the interpretation that the transfer reaction mechanism at backward angles, corresponding to small distances, may behave as a multi-step process leading to fusion. Coupled channel calculations including transfer channels are performed for the study of the sub-barrier fusion of these systems. The influence of short distance transfer reactions on the fusion is discussed. For these and other systems, the conclusions from this approach are found t to long range fusion absorptive potentials.

  15. The Discovery Channel Telescope

    Millis, R. L.; Dunham, E. W.; Sebring, T. A.; Smith, B. W.; de Kock, M.; Wiecha, O.


    The Discovery Channel Telescope (DCT) is a 4.2-m telescope to be built at a new site near Happy Jack, Arizona. The DCT features a large prime focus mosaic CCD camera with a 2-degree-diameter field of view especially designed for surveys of KBOs, Centaurs, NEAs and other moving or time-variable targets. The telescope can be switched quickly to a Ritchey-Chretien configuration for optical/IR spectroscopy or near-IR imaging. This flexibility allows timely follow-up physical studies of high priority objects discovered in survey mode. The ULE (ultra-low-expansion) meniscus primary and secondary mirror blanks for the telescope are currently in fabrication by Corning Glass. Goodrich Aerospace, Vertex RSI, M3 Engineering and Technology Corp., and e2v Technologies have recently completed in-depth conceptual design studies of the optics, mount, enclosure, and mosaic focal plane, respectively. The results of these studies were subjected to a formal design review in July, 2004. Site testing at the 7760-ft altitude Happy Jack site began in 2001. Differential image motion observations from 117 nights since January 1, 2003 gave median seeing of 0.84 arcsec FWHM, and the average of the first quartile was 0.62 arcsec. The National Environmental Policy Act (NEPA) process for securing long-term access to this site on the Coconino National Forest is nearing completion and ground breaking is expected in the spring of 2005. The Discovery Channel Telescope is a project of the Lowell Observatory with major financial support from Discovery Communications, Inc. (DCI). DCI plans ongoing television programming featuring the construction of the telescope and the research ultimately undertaken with the DCT. An additional partner can be accommodated in the project. Interested parties should contact the lead author.

  16. Search for entrance channel effects in compound nuclear formation

    Maj, A; Herskind, B; Bracco, A; Camera, F; Hagemann, G; Varmette, P


    The entrance channel effect was studied for the decay of sup 1 sup 7 sup 0 W formed in fusion reactions with different beam-target combinations. The average number of emitted neutrons suggest a lower effective excitation energy in the (alpha,xn) decay channel when more mass-symmetric reaction is used, especially at the highest angular momenta. The results are in qualitative agreement with predictions of the dissipative fusion model.

  17. Quantum Multiple Access Channel

    侯广; 黄民信; 张永德


    We consider the transmission of classical information over a quantum channel by many senders, which is a generalization of the two-sender case. The channel capacity region is shown to be a convex hull bound by the yon Neumann entropy and the conditional yon Neumann entropies. The result allows a reasonable distribution of channel capacity over the senders.

  18. Vascular potassium channels in NVC.

    Yamada, K


    It has long been proposed that the external potassium ion ([K(+)]0) works as a potent vasodilator in the dynamic regulation of local cerebral blood flow. Astrocytes may play a central role for producing K(+) outflow possibly through calcium-activated potassium channels on the end feet, responding to a rise in the intracellular Ca(2+) concentration, which might well reflect local neuronal activity. A mild elevation of [K(+)]0 in the end feet/vascular smooth muscle space could activate Na(+)/K(+)-ATPase concomitant with inwardly rectifying potassium (Kir) channels in vascular smooth muscle cells, leading to a hyperpolarization of vascular smooth muscle and relaxation of smooth muscle actin-positive vessels. Also proposed notion is endothelial calcium-activated potassium channels and/or inwardly rectifying potassium channel-mediated hyperpolarization of vascular smooth muscle. A larger elevation of [K(+)]0, which may occur pathophysiologically in such as spreading depression or stroke, can trigger a depolarization of vascular smooth muscle cells and vasoconstriction instead.

  19. Lead Poisoning Prevention Tips

    ... or removed safely. How are children exposed to lead? Lead-based paint and lead contaminated dust are ... What can be done to prevent exposure to lead? It is important to determine the construction year ...

  20. Lead (Pb) Air Pollution

    ... States Environmental Protection Agency Search Search Lead (Pb) Air Pollution Share Facebook Twitter Google+ Pinterest Contact Us As ... and protect aquatic and terrestrial ecosystems. Lead (Pb) Air Pollution Lead Air Pollution Basics How does lead get ...

  1. The MISO wiretap channel with channel uncertainty: Asymptotic perspectives

    Chaaban, Anas


    The N-antenna MISO Gaussian wiretap channel with imperfect channel-state information at the transmitter (CSIT) is studied in terms of secrecy rate scaling versus the signal-to-noise ratio (SNR) and N. Two schemes are considered, beamforming (BF) and artificial noise injection (AN). It is shown that if the CSIT error is independent of SNR, then both schemes do not achieve scaling versus SNR. However, if this error vanishes as SNR increases, then AN achieves the optimal scaling versus SNR, contrary to BF. Scaling can be achieved in BF by increasing N. In fact, BF achieves the optimal scaling versus N. In the AN scheme however, injecting noise in multiple direction deteriorates its scaling versus N. Nevertheless, AN can achieve the optimal scaling if noise is sent in only one direction. This leads to better performance than BF if the CSIT error is smaller than a threshold which is also derived.

  2. Effects of calcium ion, calpains, and calcium channel blockers on retinitis pigmentosa.

    Nakazawa, Mitsuru


    Recent advances in molecular genetic studies have revealed many of the causative genes of retinitis pigmentosa (RP). These achievements have provided clues to the mechanisms of photoreceptor degeneration in RP. Apoptosis is known to be a final common pathway in RP and, therefore, a possible therapeutic target for photoreceptor rescue. However, apoptosis is not a single molecular cascade, but consists of many different reactions such as caspase-dependent and caspase-independent pathways commonly leading to DNA fractionation and cell death. The intracellular concentration of calcium ions is also known to increase in apoptosis. These findings suggest that calpains, one of the calcium-dependent proteinases, play some roles in the process of photoreceptor apoptosis and that calcium channel antagonists may potentially inhibit photoreceptor apoptosis. Herein, the effects of calpains and calcium channel antagonists on photoreceptor degeneration are reviewed.

  3. Effects of Calcium Ion, Calpains, and Calcium Channel Blockers on Retinitis Pigmentosa

    Mitsuru Nakazawa


    Full Text Available Recent advances in molecular genetic studies have revealed many of the causative genes of retinitis pigmentosa (RP. These achievements have provided clues to the mechanisms of photoreceptor degeneration in RP. Apoptosis is known to be a final common pathway in RP and, therefore, a possible therapeutic target for photoreceptor rescue. However, apoptosis is not a single molecular cascade, but consists of many different reactions such as caspase-dependent and caspase-independent pathways commonly leading to DNA fractionation and cell death. The intracellular concentration of calcium ions is also known to increase in apoptosis. These findings suggest that calpains, one of the calcium-dependent proteinases, play some roles in the process of photoreceptor apoptosis and that calcium channel antagonists may potentially inhibit photoreceptor apoptosis. Herein, the effects of calpains and calcium channel antagonists on photoreceptor degeneration are reviewed.

  4. Ion channels in plants

    Baluška, František; Mancuso, Stefano


    In his recent opus magnum review paper published in the October issue of Physiology Reviews, Rainer Hedrich summarized the field of plant ion channels.1 He started from the earliest electric recordings initiated by Charles Darwin of carnivorous Dionaea muscipula,1,2 known as Venus flytrap, and covered the topic extensively up to the most recent discoveries on Shaker-type potassium channels, anion channels of SLAC/SLAH families, and ligand-activated channels of glutamate receptor-like type (GLR) and cyclic nucleotide-gated channels (CNGC).1 PMID:23221742

  5. Lead levels on traffic-less islands.

    Elwood, P C; Blaney, R; Robb, R C; Essex-Cater, A J; Davies, B E; Toothill, C


    Surveys were conducted on three traffic-less islands: Tory and Aran, off the coast of Ireland, and Sark, one of the Channel Islands off the coast of France. Identical methods were used in surveys in three other areas, all of which have heavy gasoline driven traffic. These were Jersey, another of the Channel Islands, Ebbw Vale--a mixed industrial area, and Cardiff--the capital city of Wales. Environmental lead levels were very low in two of the traffic-less islands, but on the third, house dust lead levels were comparable with levels found throughout Wales. Blood lead levels on one of the islands were similar to those which have been reported for unaccultured remote tribes, but on the other two traffic-less islands blood lead levels were comparable with those of areas on the mainland of Wales.

  6. Evidence of Cluster Structure of $^9$Be from $^3$He+$^9$Be Reaction

    Lukyanov, S M; Naumenko, M A; Xu, Yi; Trzaska, W H; Burjan, V; Kroha, V; Mrazek, J; Glagolev, V; Piskoř, Š; Voskoboynik, E I; Khlebnikov, S V; Penionzhkevich, Yu E; Skobelev, N K; Sobolev, Yu G; Tyurin, G P; Kuterbekov, K; Tuleushev, Yu


    The study of inelastic scattering and multi-nucleon transfer reactions was performed by bombarding a $^{9}$Be target with a $^3$He beam at an incident energy of 30 MeV. Angular distributions for $^9$Be($^3$He,$^3$He)$^{9}$Be, $^9$Be($^3$He,$^4$He)$^{8}$Be, $^9$Be($^3$He,$^5$He)$^{7}$Be, $^9$Be($^3$He,$^6$Li)$^6$Li and $^9$Be($^3$He,$^5$Li)$^7$Li reaction channels were measured. Experimental angular distributions for the corresponding ground states (g.s.) were analysed within the framework of the optical model, the coupled-channel approach and the distorted-wave Born approximation. Cross sections for channels leading to unbound $^5$He$_{g.s.}$, $^5$Li$_{g.s.}$ and $^8$Be systems were obtained from singles measurements where the relationship between the energy and the scattering angle of the observed stable ejectile is constrained by two-body kinematics. Information on the cluster structure of $^{9}$Be was obtained from the transfer channels. It was concluded that cluster transfer is an important mechanism in t...

  7. Effective radii of deuteron induced reactions

    Hashimoto, Shintaro; Ogata, Kazuyuki; Minomo, Kosho; Chiba, Satoshi


    The continuum-discretized coupled-channels method (CDCC) for exclusive reactions and the eikonal reaction theory (ERT) as an extension of CDCC to inclusive reactions are applied to deuteron induced reactions. The CDCC result reproduces experimental data on the reaction cross section for $d+^{58}$Ni scattering at 200 MeV/nucleon and ERT does data on the neutron-stripping cross section for inclusive $^7$Li$(d,n)$ reaction at 40 MeV. For deuteron induced reactions at 200 MeV/nucleon, target-dependence of the reaction, elastic-breakup, nucleon-stripping, nucleon-removal, complete- and incomplete-fusion cross sections is clearly explained by simple formulae. Accuracy of the Glauber model is also investigated.

  8. Sign ambiguity in the K Sigma channel

    Anisovich, A V; Nikonov, V A; Sarantsev, A V; Thoma, U


    Ambiguities of the signs of $N\\to \\Sigma K$ coupling constants are studied in a multichannel partial wave analysis of a large body of pion and photo-induced reactions. It is shown that the signs are not free from some ambiguities, and further experimental data are needed. Data on the reactions $\\pi^+p\\to \\Sigma^+K^+$ and $\\gamma p\\to K^+\\Sigma^0$ define rather well the isospin 3/2 contributions to these channels. However the lack of information on polarization observables for the reactions $\\pi^-p\\to \\Sigma^0K^0$, $\\pi^-p\\to \\Sigma^-K^+$ and $\\gamma p\\to K^0\\Sigma^+$ does not allow us to fix uniquely the signs of $N\\to \\Sigma K$ coupling constants. As a consequence, also the contributions of nucleon resonances to these channels remain uncertain.

  9. Protocol channels as a new design alternative of covert channels

    Wendzel, Steffen


    Covert channel techniques are used by attackers to transfer hidden data. There are two main categories of covert channels: timing channels and storage channels. This paper introduces a third category called protocol channels. A protocol channel switches one of at least two protocols to send a bit combination to a destination while sent packets include no hidden information themselves.

  10. Surface vacancy channels through ion channeling

    Redinger, Alex; Standop, Sebastian; Michely, Thomas [II. Physikalisches Institut, Universitaet Koeln, Zuelpicher Strasse 77, 50937 Koeln (Germany); Rosandi, Yudi; Urbassek, Herbert M. [Fachbereich Physik, Technische Universitaet Kaiserslautern, Erwin-Schroedinger-Strasse, D-67663 Kaiserslautern (Germany)


    Damage patterns of single ion impacts on Pt(111) have been studied by scanning tunneling microscopy (STM) and molecular dynamics simulations (MD). Low temperature experiments, where surface diffusion is absent, have been performed for argon and xenon ions with energies between 1 keV and 15 keV at an angle of incidence of 86 {sup circle} measured with respect to the surface normal. Ions hitting preexisting illuminated step edges penetrate into the crystal and are guided in open crystallographic directions, one or more layers underneath the surface (subsurface channeling). In the case of argon channeling the resulting surface damage consists of adatom and vacancy pairs aligned in ion beam direction. After xenon channeling thin surface vacancy trenches along the ion trajectories - surface vacancy channels - are observed. They result from very efficient sputtering and adatom production along the ion trajectory. This phenomena is well reproduced in molecular dynamics simulations of single ion impacts at 0 K. The damage patterns of Argon and Xenon impacts can be traced back to the different energy losses of the particles in the channel. Channeling distances exceeding 1000 A for 15 keV xenon impacts are observed.

  11. Capture reactions

    Endt, P.M.


    Capture reactions will be considered here from the viewpoint of the nuclear spectroscopist. Especially important to him are the capture of neutrons, protons, and alpha particles, which may proceed through narrow resonances, offering a well defined initial state for the subsequent deexcitation proces

  12. Allergic Reactions

    ... round, they may be caused by exposure to indoor allergens such as dust mites, indoor molds or pets. Urticaria, or hives, is characterized ... home. Video: What is an allergic reaction? » Utility navigation Donate Annual meeting Browse your conditions Check pollen ...

  13. Radiation Damping in a Focusing Channel

    Ruth, Ronald D.


    In electron storage rings synchrotron radiation leads to the damping of the three degrees of freedom of the particle trajectory towards a stable closed orbit transversely and a fixed stable phase longitudinally. At the same time, the emission of discrete quanta leads to diffusion in all three degrees of freedom. These two competing effects result in an equilibrium beam emittance that depends upon the parameters of the storage ring. In the case above, the radiation in the bending fields dominates, and the radiation due to the focusing fields is either neglected or taken into account perturbatively. In this talk we study the opposite case, a continuous focusing channel in which the radiation and its reaction are dominated by the strong focusing field. If there is a bending field, it is much weaker than the focusing field. In such focusing systems, we find that the radiation is synchrotron-like for larger betatron oscillation amplitudes and undulator-like for smaller amplitudes. However, quantum excitation is absent for any oscillation amplitude, and the damping exhibits asymmetry in favor of the transverse degree of freedom as the amplitude becomes smaller. In the undulator regime, the damping turns into exponential in the transverse direction, much faster than the total energy damping in this system. In principle, the particle could damp to the transverse ground state of the harmonic oscillator, reaching a minimum normalized emittance, γ ɛ_min = hbar/2mc, limited only by the uncertainty principle. In the case of a bent focusing system, we find that the lack of quantum excitation and asymmetric damping still hold provided that the bending field is sufficiently weak.

  14. Collective response of self-organized clusters of mechanosensitive channels.

    Guseva, Ksenia; Thiel, Marco; Booth, Ian; Miller, Samantha; Grebogi, Celso; de Moura, Alessandro


    Mechanosensitive channels are ion channels activated by membrane tension. We investigate the influence of the spatial distribution of bacterial mechanosensitive channels on activation (gating). Based on elastic short-range interactions we map this physical process onto an Ising-like model, which enables us to predict the clustering of channels and the effects of clustering on their gating. We conclude that the aggregation of channels and the consequent interactions among them leads to a global cooperative gating behavior with potentially dramatic consequences for the cell.

  15. Collective response of self-organised clusters of mechanosensitive channels

    Guseva, Ksenia; Booth, Ian; Miller, Samantha; Grebogi, Celso; de Moura, Alessandro


    Mechanosensitive channels are ion channels activated by membrane tension. We investigate the influence of bacterial mechanosensitive channels spatial distribution on activation (gating). Based on elastic short-range interactions we map this physical process onto an Ising-like model, which enables us to predict the clustering of channels and the effects of clustering on their gating. We conclude that the aggregation of channels and the consequent interactions among them leads to a global cooperative gating behaviour with potentially dramatic consequences for the cell.

  16. Impact of Channel Asymmetry on Performance of Channel Estimation and Precoding for Downlink Base Station Cooperative Transmission

    Hou, Xueying; Kiong, Buon; Lau,


    Base station (BS) cooperative transmission can improve the spectrum efficiency of cellular systems, whereas using which the channels will become asymmetry. In this paper, we study the impact of the asymmetry on the performance of channel estimation and precoding in downlink BS cooperative multiple-antenna multiple-carrier systems. We first present three linear estimators which jointly estimate the channel coefficients from users in different cells with minimum mean square error, robust design and least square criterion, and then study the impact of uplink channel asymmetry on their performance. It is shown that when the large scale channel information is exploited for channel estimation, using non-orthogonal training sequences among users in different cells leads to minor performance loss. Next, we analyze the impact of downlink channel asymmetry on the performance of precoding with channel estimation errors. Our analysis shows that although the estimation errors of weak cross links are large, the resulting r...

  17. Selective properties of neutron transfer reactions in the {sup 90}Zr + {sup 208}Pb system for the population of excited states in zirconium isotopes

    Varga Pajtler, M., E-mail: [Department of Physics, University of Osijek, HR-31000 Osijek (Croatia); Szilner, S. [Rudjer Bošković Institute, HR-10001 Zagreb (Croatia); Corradi, L.; Angelis, G. de; Fioretto, E. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, I-35020 Legnaro (Italy); Gadea, A. [IFIC, CSIC-Universidad de Valencia, E-46071 Valencia (Spain); Haas, F. [Institut Pluridisciplinaire Hubert Curien, CNRS-IN2P3 and Université de Strasbourg, F-67037 Strasbourg (France); Lunardi, S. [Dipartimento di Fisica, Universitá di Padova, and Istituto Nazionale di Fisica Nucleare, I-35131 Padova (Italy); Jelavić Malenica, D. [Rudjer Bošković Institute, HR-10001 Zagreb (Croatia); Mărginean, N. [Horia Hulubei National Institute of Physics and Nuclear Engineering, RO-077125 Bucharest-Magurele (Romania); Mengoni, D. [Dipartimento di Fisica, Universitá di Padova, and Istituto Nazionale di Fisica Nucleare, I-35131 Padova (Italy); Mijatović, T. [Rudjer Bošković Institute, HR-10001 Zagreb (Croatia); Montagnoli, G. [Dipartimento di Fisica, Universitá di Padova, and Istituto Nazionale di Fisica Nucleare, I-35131 Padova (Italy); Montanari, D. [Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, I-35020 Legnaro (Italy); Pollarolo, G. [Dipartimento di Fisica Teorica, Universitá di Torino, and Istituto Nazionale di Fisica Nucleare, I-10125 Torino (Italy); and others


    Nuclei produced via multineutron transfer channels have been studied in {sup 90}Zr + {sup 208}Pb close to the Coulomb barrier energy in a fragment-γ coincident measurement employing the PRISMA magnetic spectrometer coupled to the CLARA γ-array. The selective properties of the reaction mechanism have been discussed in terms of states and their strength excited in the neutron transfer channels leading to {sup 89–94}Zr isotopes. A strong population of yrast states, with energies up to ∼7.5 MeV has been observed.

  18. Selective properties of neutron transfer reactions in the 90Zr + 208Pb system for the population of excited states in zirconium isotopes

    Varga Pajtler, M.; Szilner, S.; Corradi, L.; de Angelis, G.; Fioretto, E.; Gadea, A.; Haas, F.; Lunardi, S.; Jelavić Malenica, D.; Mărginean, N.; Mengoni, D.; Mijatović, T.; Montagnoli, G.; Montanari, D.; Pollarolo, G.; Recchia, F.; Salsac, M.-D.; Scarlassara, F.; Soić, N.; Stefanini, A. M.; Ur, C. A.; Valiente-Dobón, J. J.


    Nuclei produced via multineutron transfer channels have been studied in 90Zr + 208Pb close to the Coulomb barrier energy in a fragment-γ coincident measurement employing the PRISMA magnetic spectrometer coupled to the CLARA γ-array. The selective properties of the reaction mechanism have been discussed in terms of states and their strength excited in the neutron transfer channels leading to 89-94Zr isotopes. A strong population of yrast states, with energies up to ∼7.5 MeV has been observed.

  19. Energetics and Dynamics of the Reactions of O(3P) with Dimethyl Methylphosphonate and Sarin

    Conforti, Patrick F.; Braunstein, Matthew; Dodd, James A.


    Electronic structure and molecular dynamics calculations were performed on the reaction systems O(3P) + sarin and O(3P) + dimethyl methylphosphonate (DMMP), a sarin simulant. Transition state geometries, energies, and heats of reaction for the major reaction pathways were determined at several levels of theory, including AM1, B3LYP/6-311+G(d,p), and CBS-QB3. The major reaction pathways for both systems are similar and include H-atom abstraction, H-atom elimination, and methyl elimination, in rough order from low to high energy. The H-atom abstraction channels have fairly low barriers (˜10 kcal mol-1) and are close to thermoneutral, while the other channels have relatively high energy barriers (>40 kcal mol-1) and a wide range of reaction enthalpies. We have also found a two-step pathway leading to methyl elimination through O-atom attack on the phosphorus atom for DMMP and sarin. For sarin, the two-step methyl elimination pathway is significantly lower in energy than the single-step pathway. We also present results of O(3P) + sarin and O(3P) + DMMP reaction cross sections over a broad range of collision energies (2-10 km s-1 collision velocities) obtained using the direct dynamics method with an AM1 semiempirical potential. These excitation functions are intended as an approximate guide to future hyperthermal measurements, which to our knowledge have not yet examined either of these systems. The reaction barriers, reaction enthalpies, transition state structures, and excitation functions are generally similar for DMMP and sarin, with some moderate differences for methyl elimination energetics, which indicates DMMP will likely be a good substitute for sarin in many O(3P) chemical investigations.

  20. Quantum channels and memory effects

    Caruso, Filippo; Giovannetti, Vittorio; Lupo, Cosmo; Mancini, Stefano


    Any physical process can be represented as a quantum channel mapping an initial state to a final state. Hence it can be characterized from the point of view of communication theory, i.e., in terms of its ability to transfer information. Quantum information provides a theoretical framework and the proper mathematical tools to accomplish this. In this context the notion of codes and communication capacities have been introduced by generalizing them from the classical Shannon theory of information transmission and error correction. The underlying assumption of this approach is to consider the channel not as acting on a single system, but on sequences of systems, which, when properly initialized allow one to overcome the noisy effects induced by the physical process under consideration. While most of the work produced so far has been focused on the case in which a given channel transformation acts identically and independently on the various elements of the sequence (memoryless configuration in jargon), correlated error models appear to be a more realistic way to approach the problem. A slightly different, yet conceptually related, notion of correlated errors applies to a single quantum system which evolves continuously in time under the influence of an external disturbance which acts on it in a non-Markovian fashion. This leads to the study of memory effects in quantum channels: a fertile ground where interesting novel phenomena emerge at the intersection of quantum information theory and other branches of physics. A survey is taken of the field of quantum channels theory while also embracing these specific and complex settings.

  1. CNG and HCN channels: two peas, one pod.

    Craven, Kimberley B; Zagotta, William N


    Cyclic nucleotide-activated ion channels play a fundamental role in a variety of physiological processes. By opening in response to intracellular cyclic nucleotides, they translate changes in concentrations of signaling molecules to changes in membrane potential. These channels belong to two families: the cyclic nucleotide-gated (CNG) channels and the hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels. The two families exhibit high sequence similarity and belong to the superfamily of voltage-gated potassium channels. Whereas HCN channels are activated by voltage and CNG channels are virtually voltage independent, both channels are activated by cyclic nucleotide binding. Furthermore, the channels are thought to have similar channel structures, leading to similar mechanisms of activation by cyclic nucleotides. However, although these channels are structurally and behaviorally similar, they have evolved to perform distinct physiological functions. This review describes the physiological roles and biophysical behavior of CNG and HCN channels. We focus on how similarities in structure and activation mechanisms result in common biophysical models, allowing CNG and HCN channels to be viewed as a single genre.

  2. Lead Aprons Are a Lead Exposure Hazard.

    Burns, Kevin M; Shoag, Jamie M; Kahlon, Sukhraj S; Parsons, Patrick J; Bijur, Polly E; Taragin, Benjamin H; Markowitz, Morri


    To determine whether lead-containing shields have lead dust on the external surface. Institutional review board approval was obtained for this descriptive study of a convenience sample of 172 shields. Each shield was tested for external lead dust via a qualitative rapid on-site test and a laboratory-based quantitative dust wipe analysis, flame atomic absorption spectrometry (FAAS). The χ(2) test was used to test the association with age, type of shield, lead sheet thickness, storage method, and visual and radiographic appearance. Sixty-three percent (95% confidence interval [CI]: 56%-70%) of the shields had detectable surface lead by FAAS and 50% (95% CI: 43%-57%) by the qualitative method. Lead dust by FAAS ranged from undetectable to 998 μg/ft(2). The quantitative detection of lead was significantly associated with the following: (1) visual appearance of the shield (1 = best, 3 = worst): 88% of shields that scored 3 had detectable dust lead; (2) type of shield: a greater proportion of the pediatric patient, full-body, and thyroid shields were positive than vests and skirts; (3) use of a hanger for storage: 27% of shields on a hanger were positive versus 67% not on hangers. Radiographic determination of shield intactness, thickness of interior lead sheets, and age of shield were unrelated to presence of surface dust lead. Sixty-three percent of shields had detectable surface lead that was associated with visual appearance, type of shield, and storage method. Lead-containing shields are a newly identified, potentially widespread source of lead exposure in the health industry. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  3. Multichannel quench-flow microreactor chip for parallel reaction monitoring

    Bula, Wojciech P.; Verboom, Willem; Reinhoudt, David N.; Gardeniers, Han J.G.E.


    This paper describes a multichannel silicon-glass microreactor which has been utilized to investigate the kinetics of a Knoevenagel condensation reaction under different reaction conditions. The reaction is performed on the chip in four parallel channels under identical conditions but with different

  4. Microwave-Accelerated Organic Reactions

    LU; TaJung


    The use of microwave technology in accelerating organic reactions has received intense attention leading to immense growth recently. Accordingly, we have been interested in improving the efficacy of organic processes by microwave irradiation. Here we report our results on the microwave assisted 1,3-dipolar cycloaddition reaction of nitrile oxides with allylic alcohols, the cleavage reaction of 1,3-diketones under alkaline conditions, and the formation of carbamates from isocyanates with alcohols. The reactions carried out under microwave irradiation, in general, required considerably less reaction time and afforded the desired products in higher yields than those under classical conditions. In all the cases we have studied, the procedures are simplified, the purity of the products are higher, and the cost of reaction is greatly reduced employing microwave.  ……

  5. Microwave-Accelerated Organic Reactions

    LU TaJung


    @@ The use of microwave technology in accelerating organic reactions has received intense attention leading to immense growth recently. Accordingly, we have been interested in improving the efficacy of organic processes by microwave irradiation. Here we report our results on the microwave assisted 1,3-dipolar cycloaddition reaction of nitrile oxides with allylic alcohols, the cleavage reaction of 1,3-diketones under alkaline conditions, and the formation of carbamates from isocyanates with alcohols. The reactions carried out under microwave irradiation, in general, required considerably less reaction time and afforded the desired products in higher yields than those under classical conditions. In all the cases we have studied, the procedures are simplified, the purity of the products are higher, and the cost of reaction is greatly reduced employing microwave.

  6. Targeting TRP channels for novel migraine therapeutics.

    Dussor, Gregory; Yan, J; Xie, Jennifer Y; Ossipov, Michael H; Dodick, David W; Porreca, Frank


    Migraine is increasingly understood to be a disorder of the brain. In susceptible individuals, a variety of "triggers" may influence altered central excitability, resulting in the activation and sensitization of trigeminal nociceptive afferents surrounding blood vessels (i.e., the trigeminovascular system), leading to migraine pain. Transient receptor potential (TRP) channels are expressed in a subset of dural afferents, including those containing calcitonin gene related peptide (CGRP). Activation of TRP channels promotes excitation of nociceptive afferent fibers and potentially lead to pain. In addition to pain, allodynia to mechanical and cold stimuli can result from sensitization of both peripheral afferents and of central pain pathways. TRP channels respond to a variety of endogenous conditions including chemical mediators and low pH. These channels can be activated by exogenous stimuli including a wide range of chemical and environmental irritants, some of which have been demonstrated to trigger migraine in humans. Activation of TRP channels can elicit CGRP release, and blocking the effects of CGRP through receptor antagonism or antibody strategies has been demonstrated to be effective in the treatment of migraine. Identification of approaches that can prevent activation of TRP channels provides an additional novel strategy for discovery of migraine therapeutics.

  7. Lead and the Romans

    Reddy, Aravind; Braun, Charles L.


    Lead poisoning has been a problem since early history and continues into modern times. An appealing characteristic of lead is that many lead salts are sweet. In the absence of cane and beet sugars, early Romans used "sugar of lead" (lead acetate) to sweeten desserts, fruits, and sour wine. People most at risk would have been those who…

  8. Lead and the Romans

    Reddy, Aravind; Braun, Charles L.


    Lead poisoning has been a problem since early history and continues into modern times. An appealing characteristic of lead is that many lead salts are sweet. In the absence of cane and beet sugars, early Romans used "sugar of lead" (lead acetate) to sweeten desserts, fruits, and sour wine. People most at risk would have been those who consumed the…

  9. Investigation of reaction mechanisms during electroreduction of carbon dioxide on lead electrode for the production of organic compounds; Etude des mecanismes reactionnels de l'electro-reduction du dioxyde de carbone sur le plomb en vue de sa transformation en des composes organiques

    Innocent, B


    The aim of this work was to promote the reduction of CO{sub 2} through its electrochemical conversion (electro-synthesis) on a lead electrode into high added value products. Depending on the nature of electrolyte, the electro-reduction of carbon dioxide leads to different products. Various electrolytes (aqueous or organic, protic or aprotic) were used to study two mechanisms: hydrogenation (formation of formate) and electro-dimerization (synthesis of oxalate). Cyclic voltammetry studies have been carried out for electrochemically characterizing CO{sub 2} reduction on Pb. The electrochemical investigation of the electrode electrolyte interface has shown that the process of CO{sub 2} electro-reduction is a mass transfer control both in the organic and aqueous media. Electrochemical experiments (cyclic voltammetry, chrono-amperometry) coupled with in situ infrared reflectance spectroscopic techniques (SPAIRS, SNIFTIRS) have also shown that in aqueous medium (7 {<=}pH{<=}9) hydrogeno-carbonate ions were reduced to formate. The modification of solvent (propylene carbonate) leads selectively to oxalate as the main reaction product. Long-term electrolyses were performed in a filter-press cell to deal large volumes. In aqueous medium, the reduction of HCO{sub 3}{sup -} to HCOO{sup -} (R{sub F} = 89% at -2.5 mA cm{sup -2} and 4 C) is always accompanied by the production of H{sub 2}. (author)

  10. Quantum broadcast channels

    Yard, J; Devetak, I; Yard, Jon; Hayden, Patrick; Devetak, Igor


    We analyze quantum broadcast channels, which are quantum channels with a single sender and many receivers. Focusing on channels with two receivers for simplicity, we generalize a number of results from the network Shannon theory literature which give the rates at which two senders can receive a common message, while a personalized one is sent to one of them. Our first collection of results applies to channels with a classical input and quantum outputs. The second class of theorems we prove concern sending a common classical message over a quantum broadcast channel, while sending quantum information to one of the receivers. The third group of results we obtain concern communication over an isometry, giving the rates at quantum information can be sent to one receiver, while common quantum information is sent to both, in the sense that tripartite GHZ entanglement is established. For each scenario, we provide an additivity proof for an appropriate class of channels, yielding single-letter characterizations of the...

  11. Volume Regulated Channels

    Klausen, Thomas Kjær

    of volume perturbations evolution have developed system of channels and transporters to tightly control volume homeostasis. In the past decades evidence has been mounting, that the importance of these volume regulated channels and transporters are not restricted to the defense of cellular volume...... but are also essential for a number of physiological processes such as proliferation, controlled cell death, migration and endocrinology. The thesis have been focusing on two Channels, namely the swelling activated Cl- channel (ICl, swell) and the transient receptor potential Vanilloid (TRPV4) channel. I: Cl......- serves a multitude of functions in the mammalian cell, regulating the membrane potential (Em), cell volume, protein activity and the driving force for facilitated transporters giving Cl- and Cl- channels a major potential of regulating cellular function. These functions include control of the cell cycle...

  12. Eikonal reaction theory

    Yahiro, Masanobu; Minomo, Kosho


    We present an accurate method of treating the one-neutron removal reaction at intermediate incident energies induced by both nuclear and Coulomb interactions. In the method, the nuclear and Coulomb breakup processes are consistently treated by the method of continuum discretized coupled channels without making the adiabatic approximation to the Coulomb interaction, so that the removal cross section calculated never diverges. This method is applied to recently measured one-neutron removal cross section for $^{31}$Ne+$^{12}$C scattering at 230 MeV/nucleon and $^{31}$Ne+$^{208}$Pb scattering at 234 MeV/nucleon. The spectroscopic factor and the asymptotic normalization coefficient of the last neutron in $^{31}$Ne are evaluated.

  13. Ion channels in asthma.

    Valverde, Miguel A; Cantero-Recasens, Gerard; Garcia-Elias, Anna; Jung, Carole; Carreras-Sureda, Amado; Vicente, Rubén


    Ion channels are specialized transmembrane proteins that permit the passive flow of ions following their electrochemical gradients. In the airways, ion channels participate in the production of epithelium-based hydroelectrolytic secretions and in the control of intracellular Ca(2+) levels that will ultimately activate almost all lung cells, either resident or circulating. Thus, ion channels have been the center of many studies aiming to understand asthma pathophysiological mechanisms or to identify therapeutic targets for better control of the disease. In this minireview, we focus on molecular, genetic, and animal model studies associating ion channels with asthma.

  14. Quantum feedback channels

    Bowen, G


    In classical information theory the capacity of a noisy communication channel cannot be increased by the use of feedback. In quantum information theory the no-cloning theorem means that noiseless copying and feedback of quantum information cannot be achieved. In this paper, quantum feedback is defined as the unlimited use of a noiseless quantum channel from receiver to sender. Given such quantum feedback, it is shown to provide no increase in the entanglement-assisted capacities of a noisy quantum channel, in direct analogy to the classical case. It is also shown that in various cases of non-assisted capacities, feedback can increase the capacity of many quantum channels.

  15. TRP channels in schistosomes

    Swarna Bais


    Full Text Available Praziquantel (PZQ is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this fact, only a few classes of parasitic helminth ion channels have been assessed for their pharmacological properties or for their roles in parasite physiology. One such overlooked group of ion channels is the transient receptor potential (TRP channel superfamily. TRP channels share a common core structure, but are widely diverse in their activation mechanisms and ion selectivity. They are critical to transducing sensory signals, responding to a wide range of external stimuli. They are also involved in other functions, such as regulating intracellular calcium and organellar ion homeostasis and trafficking. Here, we review current literature on parasitic helminth TRP channels, focusing on those in schistosomes. We discuss the likely roles of these channels in sensory and locomotor activity, including the possible significance of a class of TRP channels (TRPV that is absent in schistosomes. We also focus on evidence indicating that at least one schistosome TRP channel (SmTRPA has atypical, TRPV1-like pharmacological sensitivities that could potentially be exploited for future therapeutic targeting.

  16. KV7 potassium channels

    Stott, Jennifer B; Jepps, Thomas Andrew; Greenwood, Iain A


    identified as being crucial mediators of this process in a variety of smooth muscle. Recently, KV7 channels have been shown to be involved in the pathogenesis of hypertension, as well as being implicated in other smooth muscle disorders, providing a new and inviting target for smooth muscle disorders.......Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the KV7 family of voltage-gated potassium channels have been...

  17. Jinde Lead lead smelting project starts construction


    <正>On Dec.20,the lead smelting project of Jiangxi Jinde Lead started construction in Dexin as a technical renovation project on environmental treatment of Jiangxi Metallurgical Group.The project is the one with the largest investment of Provincial Metallurgical Group in non-ferrous

  18. Reaction dynamics and photochemistry of divalent systems

    Davis, H. Floyd [Univ. of California, Berkeley, CA (United States)


    Results are presented of molecular beam studies of bimolecular and unimolecular reactions of Ba. Chapter 1 discusses the reaction Ba + NO2. Formation of the dominant BaO(1Σ) + NO products resulted primarily from decay of long-lived Ba+NO2- collision complexes. Secondary mechanisms led to formation of forward scattered, internally excited BaO, and BaNO + O. Do(Ba-NO) = 65±20 kcal/mol. Reactions of ground state and electronically excited Ba with water and alcohols are examined in Chapter 2. Reaction of Ba(1S) + H2O led to BaO + H2, whereas excited state Ba(1D) + H2O reacted to form BaOH + H. Collisions between Ba and CH3OH led to BaOCH3 + H. Radical channels involve H-atom migration and are promoted by excitation of the incident Ba atom. In Chapter 3, reactions of Ba(1S) with ClO22 and O3 are discussed. Again, direct and complex mechanisms were observed. Formation of BaCl + O2 from decomposition of Ba+ClO2- accounted for 10% of total reaction crass section. Although Ba + O3 → BaO + 02 occurs primarily by direct reaction mechanisms, the secondary channel Ba + 03 → BaO2 + 0 involved decay of long lived Ba1+O3- intermediates. Do(Ba-O2) = 120 ±20 kcal/mol. Photodissociation dynamics of NO3 is explored in chapter 4. Visible excitation leads to formation of NO + 02 and NO2 + O. Wavelength dependence of branching ratios is investigated. Do(O-NO2) = 48.55 kcal/mole ;and calculate ΔHf(NO3) = 17.75 kcal/mole (298K). Chapter 5 discusses the photodissociation of OClO in a molecular beam. Although ClO(2II) + O(3P) is dominant, Cl(2P) + O2

  19. Kinetics of oil saponification by lead salts in ancient preparations of pharmaceutical lead plasters and painting lead mediums.

    Cotte, M; Checroun, E; Susini, J; Dumas, P; Tchoreloff, P; Besnard, M; Walter, Ph


    Lead soaps can be found in archaeological cosmetics as well as in oil paintings, as product of interactions of lead salts with oil. In this context, a better understanding of the formation of lead soaps allows a follow-up of the historical evolution of preparation recipes and provides new insights into conservation conditions. First, ancient recipes of both pharmaceutical lead plasters and painting lead mediums, mixtures of oil and lead salts, were reconstructed. The ester saponification by lead salts is determined by the preparation parameters which were quantified by FT-IR spectrometry. In particular, ATR/FT-IR spectrometer was calibrated by the standard addition method to quantitatively follow the kinetics of this reaction. The influence of different parameters such as temperature, presence of water and choice of lead salts was assessed: the saponification is clearly accelerated by water and heating. This analysis provides chemical explanations to the historical evolution of cosmetic and painting preparation recipes.

  20. Effects of partial-collapse measurement on the parameter-estimation precision of noisy quantum channels

    Liao, Xiang-Ping; Fang, Mao-Fa; Zhou, Xin


    An efficient method is proposed to enhance the parameter-estimation precision for noisy quantum channels based on measurement reversal from partial-collapse measurement. It is shown that the quantum Fisher information can be distinctly improved for amplitude-damping channel, phase-damping channel and depolarizing channel with partial-collapse measurement. This also means that choosing the appropriate measurement strengths can lead to higher precision of estimation on noisy quantum channels.

  1. Lead - nutritional considerations

    Lead poisoning - nutritional considerations; Toxic metal - nutritional considerations ... Markowitz M. Lead poisoning. In: Kliegman RM, Behrman RE, Jenson HB, ... Emergency Medicine: Concepts and Clinical Practice . 8th ed. ...

  2. Absorption-Fluctuation Theorem for Nuclear Reactions: Brink-Axel, Incomplete Fusion and All That

    Hussein, M S


    We discuss the connection between absorption, averages and fluctuations in nuclear reactions. The fluctuations in the entrance channel result in the compound nucleus, Hauser-Feshbach, cross section, the fluctuations in the intermediate channels, result in modifications of multistep reaction cross sections, while the fluctuations in the final channel result in hybrid cross sections that can be used to describe incomplete fusion reactions. We discuss the latter in details and comment on the validity of the assumptions used in the develpoment of the Surrogate method. We also discuss the theory of multistep reactions with regards to intermediate state fluctuations and the energy dependence and non-locality of the intermediate channels optical potentials.

  3. Functional diversity and evolutionary dynamics of thermoTRP channels.

    Saito, Shigeru; Tominaga, Makoto


    Animals have evolved sophisticated physiological systems for sensing ambient temperature since changes in environmental temperatures affect various biological processes. Thermosensitive transient receptor potential (thermoTRP) channels serve as thermal sensors in diverse animal species. They are multimodal receptors that are activated by temperature as well as other physical and chemical stimuli. Since thermoTRP channels are calcium permeable non-selective cation channels, their activation leads to an influx of calcium and sodium ions into the cell and triggers downstream signal transduction. ThermoTRP channels have been characterized in diverse animal species over the past several years, illuminating the diversification of thermoTRP channels in the course of evolution. The gene repertoires of thermoTRP channels differ among animal species. Additionally, in some cases, the temperature and chemical sensitivities among orthologous thermoTRP channels vary among species. The evolutionary flexibility of thermoTRP channels enabled them to contribute to unique physiological systems such as infrared sensation in snakes and bats and seasonal adaptation in silk moth. On the other hand, the functional differences of thermoTRP channels among species have been utilized for understanding the molecular basis for their activation (or inhibition) mechanisms, and amino acid residues (or domains) responsible for the respective channel properties have been identified in various thermoTRP channels. Here we summarize the current understanding of the functional diversity and evolutionary dynamics of thermoTRP channels.

  4. A linearization of quantum channels

    Crowder, Tanner


    Because the quantum channels form a compact, convex set, we can express any quantum channel as a convex combination of extremal channels. We give a Euclidean representation for the channels whose inverses are also valid channels; these are a subset of the extreme points. They form a compact, connected Lie group, and we calculate its Lie algebra. Lastly, we calculate a maximal torus for the group and provide a constructive approach to decomposing any invertible channel into a product of elementary channels.

  5. Ion channels in toxicology.

    Restrepo-Angulo, Iván; De Vizcaya-Ruiz, Andrea; Camacho, Javier


    Ion channels play essential roles in human physiology and toxicology. Cardiac contraction, neural transmission, temperature sensing, insulin release, regulation of apoptosis, cellular pH and oxidative stress, as well as detection of active compounds from chilli, are some of the processes in which ion channels have an important role. Regulation of ion channels by several chemicals including those found in air, water and soil represents an interesting potential link between environmental pollution and human diseases; for instance, de novo expression of ion channels in response to exposure to carcinogens is being considered as a potential tool for cancer diagnosis and therapy. Non-specific binding of several drugs to ion channels is responsible for a huge number of undesirable side-effects, and testing guidelines for several drugs now require ion channel screening for pharmaceutical safety. Animal toxins targeting human ion channels have serious effects on the population and have also provided a remarkable tool to study the molecular structure and function of ion channels. In this review, we will summarize the participation of ion channels in biological processes extensively used in toxicological studies, including cardiac function, apoptosis and cell proliferation. Major findings on the adverse effects of drugs on ion channels as well as the regulation of these proteins by different chemicals, including some pesticides, are also reviewed. Association of ion channels and toxicology in several biological processes strongly suggests these proteins to be excellent candidates to follow the toxic effects of xenobiotics, and as potential early indicators of life-threatening situations including chronic degenerative diseases.

  6. Water channels in peritoneal dialysis.

    Devuyst, Olivier


    Peritoneal dialysis involves diffusive and convective transports and osmosis through the highly vascularized peritoneal membrane. Several lines of evidence have demonstrated that the water channel aquaporin-1 (AQP1) corresponds to the ultrasmall pore predicted by the modelization of peritoneal transport. Proof-of-principle studies have shown that up-regulation of the expression of AQP1 in peritoneal capillaries is reflected by increased water permeability and ultrafiltration, without affecting the osmotic gradient and the permeability for small solutes. Inversely, studies in Aqp1 mice have shown that haploinsufficiency in AQP1 is reflected by significant attenuation of water transport. Recent studies have identified lead compounds that could act as agonists of aquaporins, as well as putative binding sites and potential mechanisms of gating the water channel. By modulating water transport, these pharmacological agents could have clinically relevant effects in targeting specific tissues or disease states. These studies on the peritoneal membrane also provide an experimental framework to investigate the role of water channels in the endothelium and various cell types.

  7. Potassium channels and human epileptic phenotypes: an updated overview

    Chiara eVilla


    Full Text Available Potassium (K+ channels are expressed in almost every cells and are ubiquitous in neuronal and glial cell membranes. These channels have been implicated in different disorders, in particular in epilepsy. K+ channel diversity depends on the presence in the human genome of a large number of genes either encoding pore-forming or accessory subunits. More than 80 genes encoding the K+ channels were cloned and they represent the largest group of ion channels regulating the electrical activity of cells in different tissues, including the brain. It is therefore not surprising that mutations in these genes lead to K+ channels dysfunctions linked to inherited epilepsy in humans and non-human model animals.This article reviews genetic and molecular progresses in exploring the pathogenesis of different human epilepsies, with special emphasis on the role of K+ channels in monogenic forms.

  8. A Multilevel Adaptive Reaction-splitting Simulation Method for Stochastic Reaction Networks

    Moraes, Alvaro


    In this work, we present a novel multilevel Monte Carlo method for kinetic simulation of stochastic reaction networks characterized by having simultaneously fast and slow reaction channels. To produce efficient simulations, our method adaptively classifies the reactions channels into fast and slow channels. To this end, we first introduce a state-dependent quantity named level of activity of a reaction channel. Then, we propose a low-cost heuristic that allows us to adaptively split the set of reaction channels into two subsets characterized by either a high or a low level of activity. Based on a time-splitting technique, the increments associated with high-activity channels are simulated using the tau-leap method, while those associated with low-activity channels are simulated using an exact method. This path simulation technique is amenable for coupled path generation and a corresponding multilevel Monte Carlo algorithm. To estimate expected values of observables of the system at a prescribed final time, our method bounds the global computational error to be below a prescribed tolerance, TOL, within a given confidence level. This goal is achieved with a computational complexity of order O(TOL-2), the same as with a pathwise-exact method, but with a smaller constant. We also present a novel low-cost control variate technique based on the stochastic time change representation by Kurtz, showing its performance on a numerical example. We present two numerical examples extracted from the literature that show how the reaction-splitting method obtains substantial gains with respect to the standard stochastic simulation algorithm and the multilevel Monte Carlo approach by Anderson and Higham. © 2016 Society for Industrial and Applied Mathematics.

  9. TRPM2 channels mediate acetaminophen-induced liver damage.

    Kheradpezhouh, Ehsan; Ma, Linlin; Morphett, Arthur; Barritt, Greg J; Rychkov, Grigori Y


    Acetaminophen (paracetamol) is the most frequently used analgesic and antipyretic drug available over the counter. At the same time, acetaminophen overdose is the most common cause of acute liver failure and the leading cause of chronic liver damage requiring liver transplantation in developed countries. Acetaminophen overdose causes a multitude of interrelated biochemical reactions in hepatocytes including the formation of reactive oxygen species, deregulation of Ca(2+) homeostasis, covalent modification and oxidation of proteins, lipid peroxidation, and DNA fragmentation. Although an increase in intracellular Ca(2+) concentration in hepatocytes is a known consequence of acetaminophen overdose, its importance in acetaminophen-induced liver toxicity is not well understood, primarily due to lack of knowledge about the source of the Ca(2+) rise. Here we report that the channel responsible for Ca(2+) entry in hepatocytes in acetaminophen overdose is the Transient Receptor Potential Melanostatine 2 (TRPM2) cation channel. We show by whole-cell patch clamping that treatment of hepatocytes with acetaminophen results in activation of a cation current similar to that activated by H2O2 or the intracellular application of ADP ribose. siRNA-mediated knockdown of TRPM2 in hepatocytes inhibits activation of the current by either acetaminophen or H2O2. In TRPM2 knockout mice, acetaminophen-induced liver damage, assessed by the blood concentration of liver enzymes and liver histology, is significantly diminished compared with wild-type mice. The presented data strongly suggest that TRPM2 channels are essential in the mechanism of acetaminophen-induced hepatocellular death.

  10. Calculations of Compound Nucleus Spin-Parity Distributions Populated via the (p,t Reaction in Support of Surrogate Neutron Capture Measurements

    Benstead J.


    Full Text Available The surrogate reaction method may be used to determine the cross section for neutron induced reactions not accessible through standard experimental techniques. This is achieved by creating the same compound nucleus as would be expected in the desired reaction, but through a different incident channel, generally a direct transfer reaction. So far, the surrogate technique has been applied with reasonable success to determine the fission cross section for a number of actinides, but has been less successful when applied to other reactions, e.g. neutron capture, due to a ‘spin-parity mismatch’. This mismatch, between the spin and parity distributions of the excited levels of the compound nucleus populated in the desired and surrogate channels, leads to differing decay probabilities and hence reduces the validity of using the surrogate method to infer the cross section in the desired channel. A greater theoretical understanding of the expected distribution of levels excited in both the desired and surrogate channels is therefore required in order to attempt to address this mismatch and allow the method to be utilised with greater confidence. Two neutron transfer reactions, e.g. (p,t, which allow the technique to be utilised for isotopes further removed from the line of stability, are the subject of this study. Results are presented for the calculated distribution of compound nucleus states populated in 90Zr, via the 90Zr(p,t90Zr reaction, and are compared against measured data at an incident proton energy of 28.56 MeV.

  11. Cluster knockout reactions

    Arun K Jain; B N Joshi


    Cluster knockout reactions are expected to reveal the amount of clustering (such as that of , d and even of heavier clusters such as 12C, 16O etc.) in the target nucleus. In simple terms, incident medium high-energy nuclear projectile interacts strongly with the cluster (present in the target nucleus) as if it were existing as a free entity. Theoretically, the relatively softer interactions of the two outgoing particles with the residual nucleus lead to optical distortions and are treated in terms of distorted wave (DW) formalism. The long-range projectile–cluster interaction is accounted for, in terms of the finite range (FR) direct reaction formalism, as against the more commonly adopted zero-range (ZR) distorted wave impulse approximation (DWIA) formalism. Comparison of the DWIA calculations with the observed data provide information about the momentum distribution and the clustering spectroscopic factor of the target nucleus. Interesting results and some recent advancements in the area of (, 2) reactions and heavy cluster knockout reactions are discussed. Importance of the finite-range vertex and the final-state interactions are brought out.

  12. Cryogenic current leads

    Zizek, F.


    Theoretical, technical and design questions are examined of cryogenic current leads for SP of magnetic systems. Simplified mathematical models are presented for the current leads. To illustrate modeling, the calculation is made of the real current leads for 500 A and three variants of current leads for 1500 A for the enterprise ''Shkoda.''

  13. Learn about Lead

    ... old and younger are most susceptible to the effects of lead. Children Even low levels of lead in the blood ... simple blood test to check you or your child for lead exposure. You may also want to test your home for sources ... and Technology Lead Laws and Regulations Outreach and Grants En ...

  14. Clinical relevance of ATP-dependent potassium channels

    Ligtenberg, JJM; vanHaeften, TW; Links, TP; Smit, AJ


    Many cells are equipped with so-called potassium (K+) channels which have an important role in maintaining transmembrane potential. Closure of these channels leads to membrane depolarization, which can be followed by cell-specific activity such as contraction of vascular smooth muscle, or secretion

  15. Hypersensitivity reactions associated with endovascular devices.

    Honari, Golara; Ellis, Stephen G; Wilkoff, Bruce L; Aronica, Mark A; Svensson, Lars G; Taylor, James S


    Allergic reactions to endoprostheses are uncommon and reported in association with orthopaedic, dental, endovascular and other implanted devices. Hypersensitivity reactions to the biomaterials used in endovascular prostheses are among the infrequent reactions that may lead to local or systemic complications following cardiovascular therapeutic interventions. This article reviews potential immunotoxic effects of commonly used biomaterials. Reports of putative hypersensitivity reactions to endovascular devices, including coronary stents, perforated foramen occluders, pacemakers and implantable cardioverter defibrillators are also reviewed.

  16. Generalized channeled polarimetry.

    Alenin, Andrey S; Tyo, J Scott


    Channeled polarimeters measure polarization by modulating the measured intensity in order to create polarization-dependent channels that can be demodulated to reveal the desired polarization information. A number of channeled systems have been described in the past, but their proposed designs often unintentionally sacrifice optimality for ease of algebraic reconstruction. To obtain more optimal systems, a generalized treatment of channeled polarimeters is required. This paper describes methods that enable handling of multi-domain modulations and reconstruction of polarization information using linear algebra. We make practical choices regarding use of either Fourier or direct channels to make these methods more immediately useful. Employing the introduced concepts to optimize existing systems often results in superficial system changes, like changing the order, orientation, thickness, or spacing of polarization elements. For the two examples we consider, we were able to reduce noise in the reconstruction to 34.1% and 57.9% of the original design values.

  17. Athermalized channeled spectropolarimeter enhancement.

    Jones, Julia Craven; Way, Brandyn Michael; Mercier, Jeffrey Alan; Hunt, Jeffery P.


    Channeled spectropolarimetry can measure the complete polarization state of light as a function of wavelength. Typically, a channeled spectropolarimeter uses high order retarders made of uniaxial crystal to amplitude modulate the measured spectrum with the spectrally-dependent Stokes polarization information. A primary limitation of conventional channeled spectropolarimeters is related to the thermal variability of the retarders. Thermal variation often forces frequent system recalibration, particularly for field deployed systems. However, implementing thermally stable retarders, made of biaxial crystal, results in an athermal channeled spectropolarimeter that relieves the need for frequent recalibration. This report presents experimental results for an anthermalized channeled spectropolarimeter prototype produced using potassium titanyl phosphate. The results of this prototype are compared to the current thermal stabilization state of the art. Finally, the application of the technique to the thermal infrared is studied, and the athermalization concept is applied to an infrared imaging spectropolarimeter design.

  18. Cardiac potassium channel subtypes

    Schmitt, Nicole; Grunnet, Morten; Olesen, Søren-Peter


    that they could constitute targets for new pharmacological treatment of atrial fibrillation. The interplay between the different K(+) channel subtypes in both atria and ventricle is dynamic, and a significant up- and downregulation occurs in disease states such as atrial fibrillation or heart failure......About 10 distinct potassium channels in the heart are involved in shaping the action potential. Some of the K(+) channels are primarily responsible for early repolarization, whereas others drive late repolarization and still others are open throughout the cardiac cycle. Three main K(+) channels...... drive the late repolarization of the ventricle with some redundancy, and in atria this repolarization reserve is supplemented by the fairly atrial-specific KV1.5, Kir3, KCa, and K2P channels. The role of the latter two subtypes in atria is currently being clarified, and several findings indicate...

  19. Channel erosion in a rapidly urbanizing region of Tijuana, Mexico: Enlargement downstream of channel hardpoints

    Taniguchi, Kristine; Biggs, Trent; Langendoen, Eddy; Castillo, Carlos; Gudiño, Napoleon; Yuan, Yongping; Liden, Douglas


    Urban-induced erosion in Tijuana, Mexico, has led to excessive sediment deposition in the Tijuana Estuary in the United States. Urban areas in developing countries, in contrast to developed countries, are characterized by much lower proportions of vegetation and impervious surfaces due to limited access to urban services such as road paving and landscaping, and larger proportions of exposed soils. In developing countries, traditional watershed scale variables such as impervious surfaces may not be good predictors of channel enlargement. In this research, we surveyed the stream channel network of an erodible tributary of the Tijuana River Watershed, Los Laureles Canyon, at 125 locations, including repeat surveys from 2008. Structure from Motion (SfM) and 3D photo-reconstruction techniques were used to create digital terrain models of stream reaches upstream and downstream of channel hardpoints. Channels are unstable downstream of hardpoints, with incision up to 2 meters and widening up to 12 meters. Coordinated channelization is essential to avoid piece-meal approaches that lead to channel degradation. Watershed impervious area is not a good predictor of channel erosion due to the overriding importance of hardpoints and likely to the high sediment supply from the unpaved roads which prevents channel erosion throughout the stream network.

  20. A Calibration Reaction For NIF

    Vande Kolk, B.; Chen, Y.; Deboer, R. J.; Gilardy, G.; Liu, Q.; Lyons, S.; Manukyan, K.; Moran, M.; Seymour, C.; Stech, E.; Strauss, S.; Wiescher, M.


    The National Ignition Facility (NIF) can produce a temperature range imitating that which occurs in a star during its hydrogen burning phase. The 10B(p, α)7Be reaction has been selected as a way to determine the temperatures created at NIF. The advantage of this calibration reaction is the product: Be-7 has a half-life of 53.2 days, sufficient for gathering and studying the abundance created while also decaying within several months. A 10 keV resonance exists which dominates the 10B(p, α)7Be reaction as well as 10B(p, γ)11C, another reaction channel of 10B+p. Additionally, another resonance exists for both reactions at 600 keV. There is not reliable extrapolation to the low energies corresponding to those of NIF due to the two mentioned resonances interfering, with a shared spin-parity 5/2+. Measurements were performed and will be presented for the cross-sections of the 10B(p, α)7Be and 10B(p, γ)11C reactions to more confidently extrapolate to lower energies. Research supported by NSF PHY-1419765 and JINA-CEE PHY-1430152.

  1. Lead Slowing-Down Spectrometer Research at Lansce

    Haight, R. C.; Bredeweg, T. A.; Devlin, M.; Gavron, A.; Jandel, M.; O'Donnell, J. M.; Wender, S. A.; Bélier, G.; Granier, T.; Laurent, B.; Taieb, J.; Danon, Y.; Thompson, J. T.


    The lead slowing-down spectrometer (LSDS) at Los Alamos is a 20 ton cube of lead with numerous channels, one for the proton beam from the LANSCE accelerator and others for samples and detectors. A pulsed spallation neutron source at the center of the cube is produced by the 800 MeV proton beam incident on an air-cooled tungsten target. Neutrons from this source are quickly downscattered by various reactions until their energies are less than the first excited state of 207Pb (0.57 MeV). After that, the neutrons slow down by elastic scattering where they lose on the average 1% of their energy per collision. The mean energy of the neutron distribution then changes with time as ~ 1/(t + to)2, where "to" is a constant. The low neutron absorption cross section of lead and multiple scattering of the neutrons leads to a very large neutron flux, approximately 1000 times that available in beams at the intense neutron source at the Lujan Center at LANSCE. Thus nuclear cross sections can be measured with very small samples, or conversely, very small cross sections can be measured with somewhat larger samples. Present research with the LSDS at LANSCE includes measuring fission cross sections on short-lived isotopes such as 237U, developing techniques to measure (n,p) and (n, α) cross sections, testing new types of detectors for use in the extreme radiation environment, and, in an applied context, assessing the possibility of measuring the isotopic content of actinide samples with the eventual goal of characterizing fresh and used reactor fuel rods.

  2. Spallation reactions; Reactions de spallation

    Cugon, J.


    Spallation reactions dominate the interactions of hadrons with nuclei in the GeV range (from {approx} 0.1 to {approx} 10 GeV). They correspond to a sometimes important ejection of light particles leaving most of the time a residue of mass commensurate with the target mass. The main features of the experimental data are briefly reviewed. The most successful theoretical model, namely the intranuclear cascade + evaporation model, is presented. Its physical content, results and possible improvements are critically discussed. Alternative approaches are shortly reviewed. (author). 84 refs.

  3. Heavy quark production in neutrino-nucleon reactions

    Aguiar, C.E.M. de; Simoes, J.A.M. (Rio de Janeiro Univ. (Brazil). Inst. de Fisica); Garcia Canal, C.A. (La Plata Univ. Nacional (Argentina))


    The heavy quark production (charm and bottom) in neutrino-nucleon reactions is discussed. The greater interest is in the leptonic channels, in particular in the production of two charged leptons in the final state.

  4. River channel patterns: Braided, meandering, and straight

    Leopold, Luna B.; Wolman, M. Gordon


    Channel pattern is used to describe the plan view of a reach of river as seen from an airplane, and includes meandering, braiding, or relatively straight channels. Natural channels characteristically exhibit alternating pools or deep reaches and riffles or shallow reaches, regardless of the type of pattern. The length of the pool or distance between riffles in a straight channel equals the straight line distance between successive points of inflection in the wave pattern of a meandering river of the same width. The points of inflection are also shallow points and correspond to riffles in the straight channel. This distance, which is half the wavelength of the meander, varies approximately as a linear function of channel width. In the data we analysed the meander wavelength, or twice the distance between successive riffles, is from 7 to 12 times the channel width. It is concluded that the mechanics which may lead to meandering operate in straight channels. River braiding is characterized by channel division around alluvial islands. The growth of an island begins as the deposition of a central bar which results from sorting and deposition of the coarser fractions of the load which locally cannot be transported. The bar grows downstream and in height by continued deposition on its surface, forcing the water into the flanking channels, which, to carry the flow, deepen and cut laterally into the original banks. Such deepening locally lowers the water surface and the central bar emerges as an island which becomes stabilized by vegetation. Braiding was observed in a small river in a laboratory. Measurements of the adjustments of velocity, depth, width, and slope associated with island development lead to the conclusion that braiding is one of the many patterns which can maintain quasi-equilibrium among discharge, load, and transporting ability. Braiding does not necessarily indicate an excess of total load. Channel cross section and pattern are ultimately controlled by

  5. Production of neutron-rich isotopes by cold fragmentation in the reaction {sup 197}Au + Be at 950 A MeV

    Benlliure, J.; Pereira, J. [Universidad de Santiago de Compostela (Spain)]|[Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany); Schmidt, K.H.; Cortina-Gil, D.; Enqvist, T.; Heinz, A.; Junghans, A.R. [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany); Farget, F. [Institut de Physique Nucleaire, 91 - Orsay (France); Taieb, J. [Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany)]|[Institut de Physique Nucleaire, 91 - Orsay (France)


    The production cross sections and longitudinal-momentum distributions of very neutron-rich isotopes have been investigated in the fragmentation of a 950 A MeV {sup 179}Au beam in a beryllium target. Seven new isotopes ({sup 193}Re, {sup 194}Re, {sup 191}W, {sup 192}W, {sup 189}Ta, {sup 187}Hf and {sup 188}Hf) and the five-proton-removal channel were observed for the first time. The reaction mechanism leading to the formation of these very neutron-rich isotopes is explained in terms of the cold-fragmentation process. An analytical model describing this reaction mechanism is presented. (orig.)

  6. Measurement of proton capture reactions in the hot cycles: an evaluation of experimental methods

    Leleux, P. [Inst. de Physique Nucleaire, Univ. Catholique de Louvain, Louvain-la-Neuve (Belgium)


    In the hot cycles, most of the proton capture reactions involve radioactive nuclei in the entrance and exit channels. This paper evaluates the specific methods that were designed to measure such reactions. (orig.)

  7. Fission and quasifission of composite systems with Z =108 -120 : Transition from heavy-ion reactions involving S and Ca to Ti and Ni ions

    Kozulin, E. M.; Knyazheva, G. N.; Novikov, K. V.; Itkis, I. M.; Itkis, M. G.; Dmitriev, S. N.; Oganessian, Yu. Ts.; Bogachev, A. A.; Kozulina, N. I.; Harca, I.; Trzaska, W. H.; Ghosh, T. K.


    Background: Suppression of compound nucleus formation in the reactions with heavy ions by a quasifission process in dependence on the reaction entrance channel. Purpose: Investigation of fission and quasifission processes in the reactions 36S,48Ca,48Ti , and 64Ni+238U at energies around the Coulomb barrier. Methods: Mass-energy distributions of fissionlike fragments formed in the reaction 48Ti+238U at energies of 247, 258, and 271 MeV have been measured using the double-arm time-of-flight spectrometer CORSET at the U400 cyclotron of the Flerov Laboratory of Nuclear Reactions and compared with mass-energy distributions for the reactions 36S,48Ca,64Ni+238U . Results: The most probable fragment masses as well as total kinetic energies and their dispersions in dependence on the interaction energies have been investigated for asymmetric and symmetric fragments for the studied reactions. The fusion probabilities have been deduced from the analysis of mass-energy distributions. Conclusion: The estimated fusion probability for the reactions S, Ca, Ti, and Ni ions with actinide nuclei shows that it depends exponentially on the mean fissility parameter of the system. For the reactions with actinide nuclei leading to the formation of superheavy elements the fusion probabilities are of several orders of magnitude higher than in the case of cold fusion reactions.

  8. DDESC: Dragon database for exploration of sodium channels in human

    Radovanovic Aleksandar


    Full Text Available Abstract Background Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherited genetic disorders such as febrile epilepsy, Brugada syndrome, ventricular fibrillation, long QT syndrome, or channelopathy associated insensitivity to pain. In spite of these significant effects that sodium channel proteins/genes could have on human health, there is no publicly available resource focused on sodium channels that would support exploration of the sodium channel related information. Results We report here Dragon Database for Exploration of Sodium Channels in Human (DDESC, which provides comprehensive information related to sodium channels regarding different entities, such as "genes and proteins", "metabolites and enzymes", "toxins", "chemicals with pharmacological effects", "disease concepts", "human anatomy", "pathways and pathway reactions" and their potential links. DDESC is compiled based on text- and data-mining. It allows users to explore potential associations between different entities related to sodium channels in human, as well as to automatically generate novel hypotheses. Conclusion DDESC is first publicly available resource where the information related to sodium channels in human can be explored at different levels. This database is freely accessible for academic and non-profit users via the worldwide web

  9. In-beam measurements of 13C+12C fusion reaction cross section at energies around and below Coulomb barrier

    Stefanescu, I.; Chilug, A.; Tudor, D.; Trache, L.; Straticiuc, M.; Burducea, I.; Focsa, I. M.; Ghita, D. G.; Zhang, N.; Tang, X.; Chen, H.


    The reaction cross section of the 12C+12C system is difficult to measure because of the presence of the resonances in the Gamow energy window. It has been proved that the 13C+12C reaction is a good alternative to study the behavior of the reaction cross section at energies relevant for astrophysics. We have measured it with activation and online techniques. During online measurements we were interested to determine the relative contributions of the open channels of the 13C+12C reaction. These determinations are necessary to evaluate the total fusion reaction cross section. Therefore, we have measured the γ-ray yields of proton, neutron and alpha particle evaporation channels from the resulting 25Mg compound nucleus using prompt γ-rays measurements. This complements the activation method. The irradiations took place at the 3 MV Tandetron Accelerator at IFIN-HH [1], Bucharest and the prompt gamma-rays were measured using a hyper-pure germanium detector with 100% relative efficiency, shielded with lead bricks. The energy range for the irradiation was from 4.6 up to 11 MeV (in laboratory frame), in steps of 0.2 MeV and the online measurements were performed from 6.4 up to 11 MeV.

  10. Characterization by immunocytochemistry of ionic channels in Helix aspersa suboesophageal brain ganglia neurons.

    Azanza, M J; Pérez-Castejón, C; Pes, N; Pérez-Bruzón, R N; Aisa, J; Junquera, C; Maestú, C; Lahoz, M; Martínez-Ciriano, C; Vera-Gil, A; Del Moral, A


    The aim of this work was to characterize several ionic channels in nervous cells of the suboesophageal visceral, left and right parietal, and left and right pleural brain ganglia complex of the snail Helix aspersa by immunocytochemistry. We have studied the immunostaining reaction for a wide panel of eleven polyclonal antibodies raised against mammal antigens as follows: voltage-gated-Na+ channel; voltage-gated-delayed-rectifier-K+ channel; SK2-small-conductance-Ca2+-dependent-K+ channel apamin sensitive; SK3 potassium channel; charybdotoxin-sensitive voltage-dependent potassium channel; BKCa-maxi-conductance-Ca2+-dependent-K+ channel; hyperpolarization-activated cyclic nucleotide-gated potassium channel 4; G-protein-activated inwardly rectifying potassium channel GIRK2 and voltage-gated-calcium of L, N and P/Q type channels. Our results show positive reaction in neurons, but neither in glia cells nor in processes in the Helix suboesophageal ganglia. Our results suggest the occurrence of molecules in Helix neurons sharing antigenic determinants with mammal ionic channels. The reaction density and distribution of immunoreactive staining within neurons is specific for each one of the antisera tested. The studies of co-localization of immunoreaction, on alternate serial sections of the anterior right parietal ganglion, have shown for several recognized mapped neurons that they can simultaneously be expressed among two and seven different ionic protein channels. These results are considered a key structural support for the interpretation of Helix aspersa neuron electrophysiological activity.

  11. Hybrid Multilevel Monte Carlo Simulation of Stochastic Reaction Networks

    Moraes, Alvaro


    Stochastic reaction networks (SRNs) is a class of continuous-time Markov chains intended to describe, from the kinetic point of view, the time-evolution of chemical systems in which molecules of different chemical species undergo a finite set of reaction channels. This talk is based on articles [4, 5, 6], where we are interested in the following problem: given a SRN, X, defined though its set of reaction channels, and its initial state, x0, estimate E (g(X(T))); that is, the expected value of a scalar observable, g, of the process, X, at a fixed time, T. This problem lead us to define a series of Monte Carlo estimators, M, such that, with high probability can produce values close to the quantity of interest, E (g(X(T))). More specifically, given a user-selected tolerance, TOL, and a small confidence level, η, find an estimator, M, based on approximate sampled paths of X, such that, P (|E (g(X(T))) − M| ≤ TOL) ≥ 1 − η; even more, we want to achieve this objective with near optimal computational work. We first introduce a hybrid path-simulation scheme based on the well-known stochastic simulation algorithm (SSA)[3] and the tau-leap method [2]. Then, we introduce a Multilevel Monte Carlo strategy that allows us to achieve a computational complexity of order O(T OL−2), this is the same computational complexity as in an exact method but with a smaller constant. We provide numerical examples to show our results.

  12. Study of all reaction channels in deuteron-deuteron scattering

    Ramazani-Moghaddam-Arani, A.; Amir-Ahmadi, H. R.; Bacher, A. D.; Bailey, C. D.; Biegun, A.; Eslami-Kalantari, M.; Gasparic, I.; Joulaeizadeh, L.; Kalantar-Nayestanaki, N.; Kistryn, St.; Kozela, A.; Mardanpour, H.; Messchendorp, J. G.; Micherdzinska, A. M.; Moeini, H.; Shende, S. V.; Stephan, E.; Stephenson, E. J.; Sworst, R.


    Few-nucleon systems can be used as fundamental laboratories for studying details of the nuclear force effect. We performed a series of deuteron-deuteron scattering experiments at intermediate energies. The experiments exploited BINA and BBS experimental setups and polarized deuteron beams with kinet

  13. TPC1 - SV Channels Gain Shape

    Rainer Hedrich; Irene Marten


    T The most prominent ion channel localized in plant vacuoles is the slow activating SV type. Slow vacuolar (SV)channels were discovered by patch clamp studies as early as 1986. In the following two decades, numerous studies revealed that these calcium- and voltage-activated, nonselective cation channels are expressed in the vacuoles of all plants and every plant tissue. The voltage-dependent properties of the SV channel are susceptible to modulation by calcium, pH, redox state, as well as regulatory proteins. In Arabidopsis, the SV channel is encoded by the AtTPC1 gene, and even though its gene product represents the by far largest conductance of the vacuolar membrane, tpc1-loss-of-function mutants appeared not to be impaired in major physiological functions such as growth, development, and reproduction. In contrast, the fou2 gain-of-function point mutation D454N within TPC1 leads to a pronounced growth phenotype and increased synthesis of the stress hormone jasmonate. Since the TPC1 gene is present in all land plants, it likely encodes a very general function. In this review, we will discuss major SV channel properties and their impact on plant cell physiology.

  14. Mechanism of coupling drug transport reactions located in two different membranes

    Helen I. Zgurskaya


    Full Text Available Gram- negative bacteria utilize a diverse array of multidrug transporters to pump toxic compounds out of cells. Some transporters together with periplasmic membrane fusion proteins (MFPs and outer membrane channels assemble trans-envelope complexes that expel multiple antibiotics across outer membranes of Gram-negative bacteria and into the external medium. Others further potentiate this efflux by pumping drugs across the inner membrane into the periplasm. Together these transporters create a powerful network of efflux that protect bacteria against a broad range of antimicrobial agents. This review is focused on the mechanism of coupling transport reactions located in two different membranes of Gram-negative bacteria. Using a combination of biochemical, genetic and biophysical approaches we have reconstructed the sequence of events leading to the assembly of trans-envelope drug efflux complexes and characterized the roles of periplasmic and outer membrane proteins in this process. Our recent data suggest a critical step in the activation of intermembrane efflux pumps, which is controlled by MFPs. We propose that the reaction cycles of transporters are tightly coupled to the assembly of the trans-envelope complexes. Transporters and MFPs exist in the inner membrane as dormant complexes. The activation of complexes is triggered by MFP binding to the outer membrane channel, which leads to a conformational change in the membrane proximal domain of MFP needed for stimulation of transporters. The activated MFP-transporter complex engages the outer membrane channel to expel substrates across the outer membrane. The recruitment of the channel is likely triggered by binding of effectors (substrates to MFP or MFP-transporter complexes. This model together with recent structural and functional advances in the field of drug efflux provides a fairly detailed understanding of the mechanism of drug efflux across the two membranes.

  15. Real causes of apparent abnormal results in heavy ion reactions

    Mandaglio G.


    Full Text Available We study the effect of the static characteristics of nuclei and dynamics of the nucleus-nucleus interaction in the capture stage of reaction, in the competition between quasifission and complete fusion processes, as well as the angular momentum dependence of the competition between fission and evaporation processes along the de-excitation cascade of the compound nucleus. The results calculated for the mass-asymmetric and less mass-asymmetric reactions in the entrance channel are analyzed in order to investigate the role of the dynamical effects on the yields of the evaporation residue nuclei. We also discuss about uncertainties at the extraction of such relevant physical quantities as Γn/Γtot ratio or also excitation functions from the experimental results due to the not always realistic assumptions in the treatment and analysis of the detected events. This procedure can lead to large ambiguity when the complete fusion process is strongly hindered or when the fast fission contribution is large. We emphasize that a refined multiparameter model of the reaction dynamics as well as a more detailed and checked data analysis are strongly needed in heavy-ion collisions.

  16. Bioelectronic Interface Connecting Reversible Logic Gates Based on Enzyme and DNA Reactions.

    Guz, Nataliia; Fedotova, Tatiana A; Fratto, Brian E; Schlesinger, Orr; Alfonta, Lital; Kolpashchikov, Dmitry M; Katz, Evgeny


    It is believed that connecting biomolecular computation elements in complex networks of communicating molecules may eventually lead to a biocomputer that can be used for diagnostics and/or the cure of physiological and genetic disorders. Here, a bioelectronic interface based on biomolecule-modified electrodes has been designed to bridge reversible enzymatic logic gates with reversible DNA-based logic gates. The enzyme-based Fredkin gate with three input and three output signals was connected to the DNA-based Feynman gate with two input and two output signals-both representing logically reversible computing elements. In the reversible Fredkin gate, the routing of two data signals between two output channels was controlled by the control signal (third channel). The two data output signals generated by the Fredkin gate were directed toward two electrochemical flow cells, responding to the output signals by releasing DNA molecules that serve as the input signals for the next Feynman logic gate based on the DNA reacting cascade, producing, in turn, two final output signals. The Feynman gate operated as the controlled NOT gate (CNOT), where one of the input channels controlled a NOT operation on another channel. Both logic gates represented a highly sophisticated combination of input-controlled signal-routing logic operations, resulting in redirecting chemical signals in different channels and performing orchestrated computing processes. The biomolecular reaction cascade responsible for the signal processing was realized by moving the solution from one reacting cell to another, including the reacting flow cells and electrochemical flow cells, which were organized in a specific network mimicking electronic computing circuitries. The designed system represents the first example of high complexity biocomputing processes integrating enzyme and DNA reactions and performing logically reversible signal processing. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. The human acrosome reaction

    H.W.G.Baker; D.Y.Liu; C.Garrett; M.Martic


    We developed tests of sperm-oocyte interaction: sperm-zona binding, zona-induced acrosome reaction, spermzona penetration and sperm-oolemma binding, using oocytes which failed to fertilise in clinical in vitro fertilization (IVF). Although oocyte defects contribute to failure of sperm oocyte interaction, rarely are all oocytes from one woman affected. Low or zero fertilization in standard IVFwas usually caused by sperm abnormalities. Poor sperm-zona pellucida binding was frequently associated with failure of standard IVF and obvious defects of sperm motility or morphology. The size and shape of the acrosome is particularly important for sperm binding to the oocyte. The proportion of acrosome intact sperm in the insemination medium was related to the IVF rate. Inducing the acrosome reaction with a calcium ionophore reduced sperm-zona binding. Blocking acrosome dispersal with an acrosin inhibitor prevented spermzona penetration. Sperm-zona penetration was even more highly related to IVF rates than was sperm-zona binding. Some patients had low or zero fertilization rates with standard IVF but normal sperm by conventional tests and normal sperm-zona binding. Few of their sperm underwent the acrosome reaction on the surface of the zona and none penetrated the zona. In contrast, fertilization and pregnancy rates were high with intracytoplasmic sperm injection. We call thiscondition defective zona pellucida induced acrosome reaction. Discovery of the nature of the abnormalities in the signal transduction and effector pathways of the human zona pellucida induced acrosome reaction should result in simpler tests and treatments for the patients and also provide new leads for contraceptive development.

  18. Computation over Mismatched Channels

    Karamchandani, Nikhil; Diggavi, Suhas


    We consider the problem of distributed computation of a target function over a multiple-access channel. If the target and channel functions are matched (i.e., compute the same function), significant performance gains can be obtained by jointly designing the computation and communication tasks. However, in most situations there is mismatch between these two functions. In this work, we analyze the impact of this mismatch on the performance gains achievable with joint computation and communication designs over separation-based designs. We show that for most pairs of target and channel functions there is no such gain, and separation of computation and communication is optimal.

  19. Channel Access in Erlang

    Nicklaus, Dennis J. [Fermilab


    We have developed an Erlang language implementation of the Channel Access protocol. Included are low-level functions for encoding and decoding Channel Access protocol network packets as well as higher level functions for monitoring or setting EPICS process variables. This provides access to EPICS process variables for the Fermilab Acnet control system via our Erlang-based front-end architecture without having to interface to C/C++ programs and libraries. Erlang is a functional programming language originally developed for real-time telecommunications applications. Its network programming features and list management functions make it particularly well-suited for the task of managing multiple Channel Access circuits and PV monitors.

  20. Reactions with a Metalloid Tin Cluster {Sn10[Si(SiMe3)3]4}(2-): Ligand Elimination versus Coordination Chemistry.

    Schrenk, Claudio; Gerke, Birgit; Pöttgen, Rainer; Clayborne, Andre; Schnepf, Andreas


    Chemistry that uses metalloid tin clusters as a starting material is of fundamental interest towards understanding the reactivity of such compounds. Since we identified {Sn10[Si(SiMe3)3]4}(2-) 7 as an ideal candidate for such reactions, we present a further step in the understanding of metalloid tin cluster chemistry. In contrast to germanium chemistry, ligand elimination seems to be a major reaction channel, which leads to the more open metalloid cluster {Sn10[Si(SiMe3)3]3}(-) 9, in which the Sn core is only shielded by three Si(SiMe3)3 ligands. Compound 9 is obtained through different routes and is crystallised together with two different countercations. Besides the structural characterisation of this novel metalloid tin cluster, the electronic structure is analysed by (119)Sn Mössbauer spectroscopy. Additionally, possible reaction pathways are discussed. The presented first step into the chemistry of metalloid tin clusters thus indicates that, with respect to metalloid germanium clusters, more reaction channels are accessible, thereby leading to a more complex reaction system.

  1. Controls on plan-form evolution of submarine channels

    Imran, J.; Mohrig, D. C.


    Vertically aggrading sinuous channels constitute a basic building block of modern submarine fans and the greater continental slope. Interpretation of seismically imaged channels reveals a significant diversity in internal architecture, as well as important similarities and differences in the evolution of submarine channels relative to better studied rivers. Many submarine channel cross sections possess a 'gull wing' shape. Successive stacking of such channels demonstrates that systematic bank erosion is not required in order for lateral migration to occur. The lateral shift of such aggrading channels, however, is expected to be much less dynamic than in the case of terrestrial rivers. Recent high-resolution 3D seismic data from offshore Angola and an upstream segment of the Bengal Submarine Fan show intensely meandering channels that experience considerable lateral shifting during periods of active migration within submarine valleys. The cross sections of the actively migrating channels are similar to meandering river channels characterized by an outer cut-bank and inner-bank accretion. In submarine channels, the orientation of the secondary flow can be river-like or river-reverse depending on the channel gradient, cross sectional shape, and the adaptation length of the channel bend. In river channels, a single circulation cell commonly occupies the entire channel relief, redistributing the bed-load sediment across the channel, and influencing the thread of high velocity and thus the plan-form evolution of the channel. In submarine environments, the height of the circulation cell will be significantly smaller than channel relief, thus leading to development of lower relief point bars from bed-load transport. Nevertheless these "underfit" bars may play an important role in plan-form evolution of submarine channels. In rivers and submarine channels, the inclined surface accretion can be constructed via pure bed-load, suspended-load, or a combination of both transport

  2. Intractable hyperkalemia due to nicorandil induced potassium channel syndrome

    Vivek Chowdhry


    Full Text Available Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (K ATP channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of K ATP channel, it can expel K + ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy.

  3. Channel Choice: A Literature Review

    Østergaard Madsen, Christian; Kræmmergaard, Pernille


    The channel choice branch of e-government studies citizens’ and businesses’ choice of channels for interacting with government, and how government organizations can integrate channels and migrate users towards the most cost-efficient channels. In spite of the valuable contributions offered no sys...... no systematic overview exist of channel choice. We present a literature review of channel choice studies in government to citizen context identifying authors, countries, methods, concepts, units of analysis, and theories, and offer suggestionsfor future studies....

  4. An Insight to Covert Channels

    Salwan, Nitish; Singh, Sandeep; Arora, Suket; Singh, Amarpreet


    This paper presents an overview of different concepts regarding covert channels. It discusses the various classifications and the detailing of various fields used to manipulate for the covert channel execution.Different evaluation criterias are presented for measuring the strength of covert channels. The defenses and prevention schemes for this covert channel will also be discussed. This paper also discuss about an advanced timing channel i.e.Temperature Based Covert Channel.

  5. Ring opening reaction dynamics in the reaction of hydrogen atoms with ethylene oxide

    Shin, S. K.; Jarek, R. L.; Böhmer, E.; Wittig, C.


    Ethylene oxide, C2H4O, is a three-membered ring with a single oxygen atom bridging the two carbons. Reactions of H and D atoms with ethylene oxide have been studied in the gas phase to provide insight into the dynamics of three-membered ring opening. H atoms were produced by photolyzing HI in the wavelength range 240-266 nm. The channel leading to OH+C2H4 was monitored via laser-induced fluorescence (LIF) of the OH A 2Σ←X 2Π system. The D atom reaction yields OD with no hydrogen scrambling. With an available energy of 23 000 cm-1, the average OH D rotational energy is ˜350 cm-1 for OH(v=0) and OD(v=0) and ˜250 cm-1 for OD(v=1). OH(v=1) was not observed, while the OD(v=1) population was about one-tenth that of OD(v=0). There was no apparent bias in populations between Λ doublets in each of the spin-orbit states for both OH and OD. Doppler broadening of OH(v=0) rotational lines was measured to evaluate the average center-of-mass (c.m.) translational energy, which was found to be ˜2300 cm-1. On average, the ring opening process deposits ˜10% of the available energy into c.m. translation, ˜2% into OH rotation, and ˜88% into ethylene internal energy. Comparison with CH2CH2OH unimolecular dissociation dynamics and theoretical transition state calculations leads to a likely mechanism in which hydrogen abstracts oxygen via sequential C-O bond fission without involving a long-lived CH2CH2OH intermediate.

  6. Lead and tap water

    Water contaminated with lead ... The Environmental Protection Agency (EPA) monitors drinking water in the United States. It requires water suppliers to produce annual water quality reports. These reports include information about lead amounts, and they ...

  7. Lead and Your Baby

    ... who works with lead, like in auto repair, construction or in a plant that makes paint, batteries, ... who works with lead, like in auto repair, construction or in a plant that makes paint, batteries, ...

  8. Exposures to lead.

    Callan, Anna C; Hinwood, Andrea L


    The Pacific Basin Consortium for Environment and Health hosted a workshop on Exposures to Lead. Speakers from Australia and the United States of America addressed current research knowledge on lead exposures and health effects in children, risk assessment and communication issues in dealing with lead exposure sources, different methods for assessing exposure, and the variety of scenarios where lead still remains a pollutant of concern. Mining continues to be a source of lead for many communities, and approaches to reducing exposures in these settings present particular challenges. A Perth Declaration for the Global Reduction of Childhood Lead Exposure was signed by participants of the meeting and is aimed at increasing attention to the need to continue to assess lead in the environment and to develop strategies to reduce lead in the environment and exposure by communities.

  9. Rapid Lead Screening Test

    ... Vitro Diagnostics Tests Used In Clinical Care Rapid Lead Screening Test Share Tweet Linkedin Pin it More ... reducing the need for a follow-up visit. Lead Risk Links Centers for Disease Control and Prevention ( ...

  10. Lead Poisoning (For Parents)

    ... organs and tissues that need it, thus causing anemia. Most lead ends up in the bone, where it causes ... vomiting or nausea constipation pallor (pale skin) from ... look for lead poisoning or other health problems. Treatment Treatment for ...

  11. Cooperative gating between ion channels.

    Choi, Kee-Hyun


    Cooperative gating between ion channels, i.e. the gating of one channel directly coupled to the gating of neighboring channels, has been observed in diverse channel types at the single-channel level. Positively coupled gating could enhance channel-mediated signaling while negative coupling may effectively reduce channel gating noise. Indeed, the physiological significance of cooperative channel gating in signal transduction has been recognized in several in vivo studies. Moreover, coupled gating of ion channels was reported to be associated with some human disease states. In this review, physiological roles for channel cooperativity and channel clustering observed in vitro and in vivo are introduced, and stimulation-induced channel clustering and direct channel cross linking are suggested as the physical mechanisms of channel assembly. Along with physical clustering, several molecular mechanisms proposed as the molecular basis for functional coupling of neighboring channels are covered: permeant ions as a channel coupling mediator, concerted channel activation through the membrane, and allosteric mechanisms. Also, single-channel analysis methods for cooperative gating such as the binomial analysis, the variance analysis, the conditional dwell time density analysis, and the maximum likelihood fitting analysis are reviewed and discussed.

  12. NA49: lead-lead collision


    This is an image of an actual lead ion collision taken from tracking detectors on the NA49 experiment, part of the heavy ion project at CERN. These collisions produce a very complicated array of hadrons as the heavy ions break up. It is hoped that one of these collisions will eventually create a new state of matter known as quark-gluon plasma.

  13. Occupational lead poisoning

    Ramírez, Augusto V; Médico del Trabajo. American College of Occupational and Environmental Medicine.


    Lead, a ubiquitous heavy metal, has been found in places as unlikely as Greenland’s fossil ice. Egyptians and Hebrews used it. In Spain, Phoenicians c. 2000 BC worked ores of lead. At the end of the XX century, occupational lead’s poisoning became a public health problem in developed countries. In non-developed countries occupational lead poisoning is still frequent. Diagnosis is directed to recognize lead existence at the labor environment and good clinical and occupational documentation. Di...

  14. Channelized Streams in Iowa

    Iowa State University GIS Support and Research Facility — This draft dataset consists of all ditches or channelized pieces of stream that could be identified using three input datasets; namely the1:24,000 National...

  15. Covert Channels within IRC


    Communications ....................................... 2 1.3 Steganography and Covert Channels .......................................................... 3...Internet Relay Chat ..................................................................................... 7 2.2 Steganography ...13 2.2.2 Encrypted Steganographic Systems .............................................. 15 2.2.3 Text-Based Steganography

  16. 28-Channel rotary transformer

    Mclyman, W. T.


    Transformer transmits power and digital data across rotating interface. Array has many parallel data channels, each with potential l megabaud data rate. Ferrite-cored transformers are spaced along rotor; airgap between them reduces crosstalk.

  17. Calcium channel blocker poisoning

    Miran Brvar


    Full Text Available Background: Calcium channel blockers act at L-type calcium channels in cardiac and vascular smooth muscles by preventing calcium influx into cells with resultant decrease in vascular tone and cardiac inotropy, chronotropy and dromotropy. Poisoning with calcium channel blockers results in reduced cardiac output, bradycardia, atrioventricular block, hypotension and shock. The findings of hypotension and bradycardia should suggest poisoning with calcium channel blockers.Conclusions: Treatment includes immediate gastric lavage and whole-bowel irrigation in case of ingestion of sustainedrelease products. All patients should receive an activated charcoal orally. Specific treatment includes calcium, glucagone and insulin, which proved especially useful in shocked patients. Supportive care including the use of catecholamines is not always effective. In the setting of failure of pharmacological therapy transvenous pacing, balloon pump and cardiopulmonary by-pass may be necessary.

  18. Volume Regulated Channels

    Klausen, Thomas Kjær

    - serves a multitude of functions in the mammalian cell, regulating the membrane potential (Em), cell volume, protein activity and the driving force for facilitated transporters giving Cl- and Cl- channels a major potential of regulating cellular function. These functions include control of the cell cycle...... of volume perturbations evolution have developed system of channels and transporters to tightly control volume homeostasis. In the past decades evidence has been mounting, that the importance of these volume regulated channels and transporters are not restricted to the defense of cellular volume......, controlled cell death and cellular migration. Volume regulatory mechanisms has long been in focus for regulating cellular proliferation and my thesis work have been focusing on the role of Cl- channels in proliferation with specific emphasis on ICl, swell. Pharmacological blockage of the ubiquitously...

  19. Authentication over Noisy Channels

    Lai, Lifeng; Poor, H Vincent


    In this work, message authentication over noisy channels is studied. The model developed in this paper is the authentication theory counterpart of Wyner's wiretap channel model. Two types of opponent attacks, namely impersonation attacks and substitution attacks, are investigated for both single message and multiple message authentication scenarios. For each scenario, information theoretic lower and upper bounds on the opponent's success probability are derived. Remarkably, in both scenarios, lower and upper bounds are shown to match, and hence the fundamental limit of message authentication over noisy channels is fully characterized. The opponent's success probability is further shown to be smaller than that derived in the classic authentication model in which the channel is assumed to be noiseless. These results rely on a proposed novel authentication scheme in which key information is used to provide simultaneous protection again both types of attacks.

  20. Coding for optical channels

    Djordjevic, Ivan; Vasic, Bane


    This unique book provides a coherent and comprehensive introduction to the fundamentals of optical communications, signal processing and coding for optical channels. It is the first to integrate the fundamentals of coding theory and optical communication.

  1. Cl- channels in apoptosis

    Wanitchakool, Podchanart; Ousingsawat, Jiraporn; Sirianant, Lalida


    , and cystic fibrosis transmembrane conductance regulator (CFTR) in cellular apoptosis. LRRC8A-E has been identified as a volume-regulated anion channel expressed in many cell types. It was shown to be required for regulatory and apoptotic volume decrease (RVD, AVD) in cultured cell lines. Its presence also......(-) channels or as regulators of other apoptotic Cl(-) channels, such as LRRC8. CFTR has been known for its proapoptotic effects for some time, and this effect may be based on glutathione release from the cell and increase in cytosolic reactive oxygen species (ROS). Although we find that CFTR is activated...... by cell swelling, it is possible that CFTR serves RVD/AVD through accumulation of ROS and activation of independent membrane channels such as ANO6. Thus activation of ANO6 will support cell shrinkage and induce additional apoptotic events, such as membrane phospholipid scrambling....

  2. Sensing with Ion Channels

    Martinac, Boris


    All living cells are able to detect and translate environmental stimuli into biologically meaningful signals. Sensations of touch, hearing, sight, taste, smell or pain are essential to the survival of all living organisms. The importance of sensory input for the existence of life thus justifies the effort made to understand its molecular origins. Sensing with Ion Channels focuses on ion channels as key molecules enabling biological systems to sense and process the physical and chemical stimuli that act upon cells in their living environment. Its aim is to serve as a reference to ion channel specialists and as a source of new information to non specialists who want to learn about the structural and functional diversity of ion channels and their role in sensory physiology.

  3. Links between potential energy structures and quantum cumulative reaction probabilities of double proton transfer reactions

    Horsten, H.F. von [Institut fuer Physikalische Chemie, Christian-Albrechts-Universitaet, Olshausenstrasse 40, 24098 Kiel (Germany); Hartke, B. [Institut fuer Physikalische Chemie, Christian-Albrechts-Universitaet, Olshausenstrasse 40, 24098 Kiel (Germany)], E-mail:


    Double proton transfer reactions of pyrazole-guanidine species exhibit unusual energy profiles of a plateau form, different from the standard single and double barrier shapes. We have demonstrated earlier that this leads to a characteristically different quantum dynamical behavior of plateau reactions, when measured appropriately. Here we show that these differences also carry over to traditional measures of reaction probability.

  4. Lead Poisoning in Children.

    Drummond, A. H., Jr.


    Early symptoms of lead poisoning in children are often overlooked. Lead poisoning has its greatest effects on the brain and nervous system. The obvious long-term solution to the lead poisoning problem is removal of harmful forms of the metal from the environment. (JN)

  5. Atrioventricular Pacemaker Lead Reversal

    Mehmet K Aktas, MD


    Full Text Available During cardiac surgery temporary epicardial atrial and ventricular leads are placed in case cardiac pacing is required postoperatively. We present the first reported series of patients with reversal of atrioventricular electrodes in the temporary pacemaker without any consequent deleterious hemodynamic effect. We review the electrocardiographic findings and discuss the findings that lead to the discovery of atrioventricular lead reversal.

  6. Chloride channels in stroke

    Ya-ping ZHANG; Hao ZHANG; Dayue Darrel DUAN


    Vascular remodeling of cerebral arterioles,including proliferation,migration,and apoptosis of vascular smooth muscle cells (VSMCs),is the major cause of changes in the cross-sectional area and diameter of the arteries and sudden interruption of blood flow or hemorrhage in the brain,ie,stroke.Accumulating evidence strongly supports an important role for chloride (Clˉ) channels in vascular remodeling and stroke.At least three Clˉ channel genes are expressed in VSMCs:1) the TMEM16A (or Ano1),which may encode the calcium-activated Clˉ channels (CACCs); 2) the CLC-3 Clˉ channel and Clˉ/H+ antiporter,which is closely related to the volume-regulated Clˉ channels (VRCCs); and 3) the cystic fibrosis transmembrane conductance regulator (CFTR),which encodes the PKA-and PKC-activated Clˉ channels.Activation of the CACCs by agonist-induced increase in intracellular Ca2+ causes membrane depolarization,vasoconstriction,and inhibition of VSMC proliferation.Activation of VRCCs by cell volume increase or membrane stretch promotes the production of reactive oxygen species,induces proliferation and inhibits apoptosis of VSMCs.Activation of CFTR inhibits oxidative stress and may prevent the development of hypertension.In addition,Clˉ current mediated by gammaaminobutyric acid (GABA) receptor has also been implicated a role in ischemic neuron death.This review focuses on the functional roles of Clˉ channels in the development of stroke and provides a perspective on the future directions for research and the potential to develop Clˉ channels as new targets for the prevention and treatment of stroke.

  7. Competing E2 and SN2 Mechanisms for the F(-) + CH3CH2I Reaction.

    Yang, Li; Zhang, Jiaxu; Xie, Jing; Ma, Xinyou; Zhang, Linyao; Zhao, Chenyang; Hase, William L


    Anti-E2, syn-E2, inv-, and ret-SN2 reaction channels for the gas-phase reaction of F(-) + CH3CH2I were characterized with a variety of electronic structure calculations. Geometrical analysis confirmed synchronous E2-type transition states for the elimination of the current reaction, instead of nonconcerted processes through E1cb-like and E1-like mechanisms. Importantly, the controversy concerning the reactant complex for anti-E2 and inv-SN2 paths has been clarified in the present work. A positive barrier of +19.2 kcal/mol for ret-SN2 shows the least feasibility to occur at room temperature. Negative activation energies (-16.9, -16.0, and -4.9 kcal/mol, respectively) for inv-SN2, anti-E2, and syn-E2 indicate that inv-SN2 and anti-E2 mechanisms significantly prevail over the eclipsed elimination. Varying the leaving group for a series of reactions F(-) + CH3CH2Y (Y = F, Cl, Br, and I) leads to monotonically decreasing barriers, which relates to the gradually looser TS structures following the order F > Cl > Br > I. The reactivity of each channel nearly holds unchanged except for the perturbation between anti-E2 and inv-SN2. RRKM calculation reveals that the reaction of the fluorine ion with ethyl iodide occurs predominately via anti-E2 elimination, and the inv-SN2 pathway is suppressed, although it is energetically favored. This phenomenon indicates that, in evaluating the competition between E2 and SN2 processes, the kinetic or dynamical factors may play a significant role. By comparison with benchmark CCSD(T) energies, MP2, CAM-B3LYP, and M06 methods are recommended to perform dynamics simulations of the title reaction.

  8. Biological Membrane Ion Channels Dynamics, Structure, and Applications

    Chung, Shin-Ho; Krishnamurthy, Vikram


    Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences. Key Features Presents the latest information on the molecular mechanisms of ion permeation through membrane ion channels Uses schematic diagrams to illustrate important concepts in biophysics Written by leading researchers in the area of ion channel investigations

  9. Pricing Decision under Dual-Channel Structure considering Fairness and Free-Riding Behavior

    Yongmei Liu


    Full Text Available Under dual-channel structure, the free-riding behavior based on different service levels between online channel and offline channel cannot be avoided, which would lead to channel unfairness. This study implies that the dual-channel supply chain is built up by online channel controlled by manufacturer and traditional channel controlled by retailer, respectively. Under this channel structure, we rebuild the linear demand function considering free-riding behavior and modify the pricing model based on channel fairness. Then the influences of fair factor and free-riding behavior on manufacturer and retailer pricing and performance are discussed. Finally, we propose some numerical analysis to provide some valuable recommendations for manufacturer and retailer improving channel management performance.

  10. Course on Ionic Channels


    This book is based on a series of lectures for a course on ionic channels held in Santiago, Chile, on November 17-20, 1984. It is intended as a tutorial guide on the properties, function, modulation, and reconstitution of ionic channels, and it should be accessible to graduate students taking their first steps in this field. In the presentation there has been a deliberate emphasis on the spe­ cific methodologies used toward the understanding of the workings and function of channels. Thus, in the first section, we learn to "read" single­ channel records: how to interpret them in the theoretical frame of kinetic models, which information can be extracted from gating currents in re­ lation to the closing and opening processes, and how ion transport through an open channel can be explained in terms of fluctuating energy barriers. The importance of assessing unequivocally the origin and purity of mem­ brane preparations and the use of membrane vesicles and optical tech­ niques in the stUGY of ionic channels a...

  11. Fracture channel waves

    Nihei, Kurt T.; Yi, Weidong; Myer, Larry R.; Cook, Neville G. W.; Schoenberg, Michael


    The properties of guided waves which propagate between two parallel fractures are examined. Plane wave analysis is used to obtain a dispersion equation for the velocities of fracture channel waves. Analysis of this equation demonstrates that parallel fractures form an elastic waveguide that supports two symmetric and two antisymmetric dispersive Rayleigh channel waves, each with particle motions and velocities that are sensitive to the normal and tangential stiffnesses of the fractures. These fracture channel waves degenerate to shear waves when the fracture stiffnesses are large, to Rayleigh waves and Rayleigh-Lamb plate waves when the fracture stiffnesses are low, and to fracture interface waves when the fractures are either very closely spaced or widely separated. For intermediate fracture stiffnesses typical of fractured rock masses, fracture channel waves are dispersive and exhibit moderate to strong localization of guided wave energy between the fractures. The existence of these waves is examined using laboratory acoustic measurements on a fractured marble plate. This experiment confirms the distinct particle motion of the fundamental antisymmetric fracture channel wave (A0 mode) and demonstrates the ease with which a fracture channel wave can be generated and detected.

  12. Differences between main-channel and off-channel food webs in the upper Mississippi River revealed by fatty acid profiles of consumers

    Larson, James H.; Bartsch, Michelle; Gutreuter, Steve; Knights, Brent C.; Bartsch, Lynn; Richardson, William B.; Vallazza, Jonathan M.; Arts, Michael T.


    Large river systems are often thought to contain a mosaic of patches with different habitat characteristics driven by differences in flow and mixing environments. Off-channel habitats (e.g., backwater areas, secondary channels) can become semi-isolated from main-channel water inputs, leading to the development of distinct biogeochemical environments. Observations of adult bluegill (Lepomis macrochirus) in the main channel of the Mississippi River led to speculation that the main channel offered superior food resources relative to off-channel areas. One important aspect of food quality is the quantity and composition of polyunsaturated fatty acids (PUFA). We sampled consumers from main-channel and backwater habitats to determine whether they differed in PUFA content. Main-channel individuals for relatively immobile species (young-of-year bluegill, zebra mussels [Dreissena polymorpha], and plain pocketbook mussels [Lampsilis cardium]) had significantly greater PUFA content than off-channel individuals. No difference in PUFA was observed for the more mobile gizzard shad (Dorsoma cepedianum), which may move between main-channel and off-channel habitats even at early life-history stages. As off-channel habitats become isolated from main-channel waters, flow and water column nitrogen decrease, potentially improving conditions for nitrogen-fixing cyanobacteria and vascular plants that, in turn, have low PUFA content. We conclude that main-channel food webs of the upper Mississippi River provide higher quality food resources for some riverine consumers as compared to food webs in off-channel habitats.

  13. Allowed energetic pathways for the three-body recombination reaction of nitrogen monoxide with the hydroxyl radical and their potential atmospheric implications

    Luca D´Ottone


    Full Text Available The OH initiated oxidation of nitric oxide (NO is an important atmospheric reaction being, during the day time, the main channel that leads to the formation of HONO a reservoir species for both OH and odd nitrogen. This work reports ab initio study of the Potential Energy Surface (PES of NO + OH using density functional theory calculations conducted at the B3LYP level of theory with a 6-311g (d,p basis set. We confirmed experimental observations pointing out that the main channel for this reaction is the formation the HONO. From the addition of OH to NO both cis and trans isomers of HONO were found to be the formed as stable intermediate, both having a negative enthalpy of formation relative to the reactants, the cis isomer being more stable than the trans one. The ab initio calculations were extended to include the hydrogen extraction mechanism with its respective transition state to investigate the potential existence of a reaction channel leading to the formation of NO2 + H, that was found not to be of significant interest.

  14. ALICE: Simulated lead-lead collision


    This track is an example of simulated data modelled for the ALICE detector on the Large Hadron Collider (LHC) at CERN, which will begin taking data in 2008. ALICE will focus on the study of collisions between nuclei of lead, a heavy element that produces many different particles when collided. It is hoped that these collisions will produce a new state of matter known as the quark-gluon plasma, which existed billionths of a second after the Big Bang.

  15. Channel Capacity of DWDM Networks with Cross-phase Modulation Effect


    In dense wavelength division multiplexing(DWDM) optical transmission systems, cross phase modulation(XPM) due to Kerr effect causes phase shift and intensity modulation in each channel, which will lead the channel capacity to be a random variable. An expression of the channel capacity dealing with XPM effect is presented, and the correctness and accuracy of this method are demonstrated by numerical simulation.

  16. Capacity Bounds for Parallel Optical Wireless Channels

    Chaaban, Anas


    A system consisting of parallel optical wireless channels with a total average intensity constraint is studied. Capacity upper and lower bounds for this system are derived. Under perfect channel-state information at the transmitter (CSIT), the bounds have to be optimized with respect to the power allocation over the parallel channels. The optimization of the lower bound is non-convex, however, the KKT conditions can be used to find a list of possible solutions one of which is optimal. The optimal solution can then be found by an exhaustive search algorithm, which is computationally expensive. To overcome this, we propose low-complexity power allocation algorithms which are nearly optimal. The optimized capacity lower bound nearly coincides with the capacity at high SNR. Without CSIT, our capacity bounds lead to upper and lower bounds on the outage probability. The outage probability bounds meet at high SNR. The system with average and peak intensity constraints is also discussed.

  17. Markov modeling of ion channels: implications for understanding disease.

    Lampert, Angelika; Korngreen, Alon


    Ion channels are the bridge between the biochemical and electrical domains of our life. These membrane crossing proteins use the electric energy stored in transmembrane ion gradients, which are produced by biochemical activity to generate ionic currents. Each ion channel can be imagined as a small power plant similar to a hydroelectric power station, in which potential energy is converted into electric current. This current drives basically all physiological mechanisms of our body. It is clear that a functional blueprint of these amazing cellular power plants is essential for understanding the principle of all aspects of physiology, particularly neurophysiology. The golden path toward this blueprint starts with the biophysical investigation of ion channel activity and continues through detailed numerical modeling of these channels that will eventually lead to a full system-level description of cellular and organ physiology. Here, we discuss the first two stages of this process focusing on voltage-gated channels, particularly the voltage-gated sodium channel which is neurologically and pathologically important. We first detail the correlations between the known structure of the channel and its activity and describe some pathologies. We then provide a hands-on description of Markov modeling for voltage-gated channels. These two sections of the chapter highlight the dichotomy between the vast amounts of electrophysiological data available on voltage-gated channels and the relatively meager number of physiologically relevant models for these channels.

  18. Rescue of mutated cardiac ion channels in inherited arrhythmia syndromes.

    Balijepalli, Sadguna Y; Anderson, Corey L; Lin, Eric C; January, Craig T


    Inherited arrhythmia syndromes comprise an increasingly complex group of diseases involving mutations in multiple genes encoding ion channels, ion channel accessory subunits and channel interacting proteins, and various regulatory elements. These mutations serve to disrupt normal electrophysiology in the heart, leading to increased arrhythmogenic risk and death. These diseases have added impact as they often affect young people, sometimes without warning. Although originally thought to alter ion channel function, it is now increasingly recognized that mutations may alter ion channel protein and messenger RNA processing, to reduce the number of channels reaching the surface membrane. For many of these mutations, it is also known that several interventions may restore protein processing of mutant channels to increase their surface membrane expression toward normal. In this article, we reviewed inherited arrhythmia syndromes, focusing on long QT syndrome type 2, and discuss the complex biology of ion channel trafficking and pharmacological rescue of disease-causing mutant channels. Pharmacological rescue of misprocessed mutant channel proteins, or their transcripts providing appropriate small molecule drugs can be developed, has the potential for novel clinical therapies in some patients with inherited arrhythmia syndromes.


    Carlo Gustavino


    Full Text Available The 2H(α, γ6Li reaction is the leading process for the production of 6Li in standard Big Bang Nucleosynthesis. Recent observations of lithium abundance in metal-poor halo stars suggest that there might be a 6Li plateau, similar to the well-known Spite plateau of 7Li. This calls for a re-investigation of the standard production channel for 6Li. As the 2H(α, γ6Li cross section drops steeply at low energy, it has never before been studied directly at Big Bang energies. For the first time the reaction has been studied directly at Big Bang energies at the LUNA accelerator. The preliminary data and their implications for Big Bang nucleosynthesis and the purported 6Li problem will be shown.

  20. The influence of the "cage effect" on the mechanism of reversible bimolecular multistage chemical reactions in solutions.

    Doktorov, Alexander B


    Manifestations of the "cage effect" at the encounters of reactants are theoretically treated by the example of multistage reactions in liquid solutions including bimolecular exchange reactions as elementary stages. It is shown that consistent consideration of quasi-stationary kinetics of multistage reactions (possible only in the framework of the encounter theory) for reactions proceeding near reactants contact can be made on the basis of the concepts of a "cage complex." Though mathematically such a consideration is more complicated, it is more clear from the standpoint of chemical notions. It is established that the presence of the "cage effect" leads to some important effects not inherent in reactions in gases or those in solutions proceeding in the kinetic regime, such as the appearance of new transition channels of reactant transformation that cannot be caused by elementary event of chemical conversion for the given mechanism of reaction. This results in that, for example, rate constant values of multistage reaction defined by standard kinetic equations of formal chemical kinetics from experimentally measured kinetics can differ essentially from real values of these constants.

  1. Pool spacing in forest channels

    David R. Montgomery; John M. Buffington; Richard D. Smith; Kevin M. Schmidt; George Pess


    Field surveys of stream channels in forested mountain drainage basins in southeast Alaska and Washington reveal that pool spacing depends on large woody debris (LWD) loading and channel type, slope, and width. Mean pool spacing in pool-riffle, plane-bed, and forced pool-riffle channels systematically decreases from greater than 13 channel widths per pool to less than 1...

  2. Probability and risk criteria for channel depth design and channel operation

    Moes, H


    Full Text Available The paper reviews the various levels of probability of bottom touching and risk criteria which are being used. This leads to a relationship between the statistically expected number of vertical ship motions in the channel during a single shipping...

  3. Lead-Free Piezoelectrics

    Nahm, Sahn


    Ecological restrictions in many parts of the world are demanding the elimination of Pb from all consumer items. At this moment in the piezoelectric ceramics industry, there is no issue of more importance than the transition to lead-free materials. The goal of Lead-Free Piezoelectrics is to provide a comprehensive overview of the fundamentals and developments in the field of lead-free materials and products to leading researchers in the world. The text presents chapters on demonstrated applications of the lead-free materials, which will allow readers to conceptualize the present possibilities and will be useful for both students and professionals conducting research on ferroelectrics, piezoelectrics, smart materials, lead-free materials, and a variety of applications including sensors, actuators, ultrasonic transducers and energy harvesters.

  4. Lead Poison Detection


    With NASA contracts, Whittaker Corporations Space Science division has developed an electro-optical instrument to mass screen for lead poisoning. Device is portable and detects protoporphyrin in whole blood. Free corpuscular porphyrins occur as an early effect of lead ingestion. Also detects lead in urine used to confirm blood tests. Test is inexpensive and can be applied by relatively unskilled personnel. Similar Whittaker fluorometry device called "drug screen" can measure morphine and quinine in urine much faster and cheaper than other methods.

  5. Removal of lead from crude antimony by using NaPo3 as lead elimination reagent

    Ye L.G.


    Full Text Available In order to solve the shortcomings when removing lead from crude antimony in the traditional antimony smelting, a new process was provided using NaPO3 as lead elimination reagent to yield phosphate slag, and it was removed by floating on the surface of the liquid antimony. Reaction mechanism was clarified by using the TG-DTA and XRD techniques and single factor experiments of removal lead from crude antimony were engaged. The results show that PbO and NaPO3 begin endothermic reaction at 863K (590°C, and the reaction mainly form NaPb4(PO43 and NaPbPO4 below 1123K (850°C and above 1123K (850°C, respectively. Sb2O3 and NaPO3 start the reaction at 773K (500°C and generate an antimonic salt compound. The reaction product of the mixture of PbO, Sb2O3 and NaPO3 show that NaPO3 reacted with PbO prior when NaPO3 was insufficient, amorphous antimony glass will be generated only when NaPO3 was adequate. Single factor experiments were taken with NaNO3 as oxidizing agent under argon, effect of reaction time, reaction temperature and dosage of NaPO3 and NaNO3 on smelting results. The average content of lead in refined antimony was 0.05340% and 98.85% of lead were removed under optimal conditions; the content of lead in antimony have meet the requirements of commercial antimony.

  6. Coupled-channel study of gamma p --> K+ Lambda

    Chiang, W T; Lee, T S H; Saghai, B; Chiang, Wen-Tai


    A coupled-channel (CC) approach has been developed to investigate kaon photoproduction on the nucleon. In addition to direct $K^+ \\Lambda$ production, our CC approach accounts for strangeness production including $K^+ \\Lambda$ final state interactions with both $\\pi^0 p$ and $\\pi^+ n$ intermediate states. Calculations for the $\\gamma p \\to K^+ \\Lambda$ reaction have been performed, and compared with the recent data from SAPHIR, with emphasis on the CC effects. We show that the CC effects are significant at the level of inducing 20% changes on total cross sections; thereby, demonstrating the need to include $\\pi N$ channels to correctly describe the $\\gamma p \\to K^+ \\Lambda$ reaction.

  7. Calcium channels and migraine.

    Pietrobon, Daniela


    Missense mutations in CACNA1A, the gene that encodes the pore-forming α1 subunit of human voltage-gated Ca(V)2.1 (P/Q-type) calcium channels, cause a rare form of migraine with aura (familial hemiplegic migraine type 1: FHM1). Migraine is a common disabling brain disorder whose key manifestations are recurrent attacks of unilateral headache that may be preceded by transient neurological aura symptoms. This review, first, briefly summarizes current understanding of the pathophysiological mechanisms that are believed to underlie migraine headache, migraine aura and the onset of a migraine attack, and briefly describes the localization and function of neuronal Ca(V)2.1 channels in the brain regions that have been implicated in migraine pathogenesis. Then, the review describes and discusses i) the functional consequences of FHM1 mutations on the biophysical properties of recombinant human Ca(V)2.1 channels and native Ca(V)2.1 channels in neurons of knockin mouse models carrying the mild R192Q or severe S218L mutations in the orthologous gene, and ii) the functional consequences of these mutations on neurophysiological processes in the cerebral cortex and trigeminovascular system thought to be involved in the pathophysiology of migraine, and the insights into migraine mechanisms obtained from the functional analysis of these processes in FHM1 knockin mice. This article is part of a Special Issue entitled: Calcium channels. Copyright © 2012 Elsevier B.V. All rights reserved.

  8. Channel Identification Machines

    Aurel A. Lazar


    Full Text Available We present a formal methodology for identifying a channel in a system consisting of a communication channel in cascade with an asynchronous sampler. The channel is modeled as a multidimensional filter, while models of asynchronous samplers are taken from neuroscience and communications and include integrate-and-fire neurons, asynchronous sigma/delta modulators and general oscillators in cascade with zero-crossing detectors. We devise channel identification algorithms that recover a projection of the filter(s onto a space of input signals loss-free for both scalar and vector-valued test signals. The test signals are modeled as elements of a reproducing kernel Hilbert space (RKHS with a Dirichlet kernel. Under appropriate limiting conditions on the bandwidth and the order of the test signal space, the filter projection converges to the impulse response of the filter. We show that our results hold for a wide class of RKHSs, including the space of finite-energy bandlimited signals. We also extend our channel identification results to noisy circuits.

  9. On one-qubit channels

    Verstraete, F; Verstraete, Frank; Verschelde, Henri


    We use the duality between completely positive linear maps and states to characterize all possible 1-qubit channels. This leads to a transparent way of characterizing all extreme points of the set of completely positive trace preserving maps. We show that these extremal maps arise in a natural way in problems such as to optimally enhance fidelity and optimal cloning. Next we use normal forms, previously derived for mixed states of two qubits, to derive interesting representations of CP-maps. It follows that a generic CP-map on 1 qubit can be interpreted as being a composition of a (reversible) filtering operation, followed by a unital map, followed by filtering again. It is furthermore shown that a map is entanglement breaking iff the dual state associated to it is separable, and how this implies that the Kraus operators can be chosen to be all of rank one.

  10. Progress in all-order breakup reaction theories

    R Chatterjee


    Progress in breakup reaction theories, like the distorted wave Born approximation, the continuum discretized coupled channels method and the dynamical eikonal approximation, is brought into focus. The need to calculate exclusive reaction observables and the utility of benchmark tests as arbitrators of theoretical models are discussed.

  11. 微波消解—碰撞反应池技术电感耦合等离子体质谱法测定食品中的铅%Determination of lead in foods by inductively coupled plasma mass spectrometry based on collided reaction cell technology after microwave digestion

    殷忠; 周彬; 汪思顺


    OBJECTIVE To establish a method for determination of lead in foods by inductively coupled plasma mass spectrometry based on collided reaction cell technology after microwave digestion.METHODS After microwave digestion,the samples were directly determined by inductively coupled plasma mass spectrometry based on collided reaction cell technology.Internal standard element of Thallium (204TI) was used to correct matrix interference and signal drifting,high-performance Xs interface was used to reduce non-mass spectrum interferences,and the collided reaction cell technology (CCT mode) was used to eliminate mass spectrum interferences.RESULTS The optimal linear range of the method was 0-40μg/L with a correlation coefficient of 0.999 8.The detection limit of the method,the lowest quantitative limit,the relative standard deviation and the recovery rate were 0.000 5 mg/kg,0.001 7 mg/kg,1.1%-3.8% and 93.3%-104.0%,respectively.CONCLUSION The method is sensitive,accurate,simple and fast.There is no significant difference between the results from the method and graphic furnace atomic absorption spectrometry and is suitable for analysis of lead in foods.%目的 建立食品中铅的微波消解—碰撞反应池技术电感耦合等离子体质谱法.方法 样品经微波消化后直接用碰撞反应池电感技术的耦合等离子体质谱仪(ICP-MS)进行测定.用铊(204TI)内标校正基体干扰和漂移,用高性能Xs接口降低非质谱干扰,用碰撞反应池技术(CCT模式)消除质谱干扰.结果 方法的标准曲线线性范围为0~40μg/L,相关系数为0.999 8.方法检出限为0.000 5mg/kg,最低检出浓度为0.001 7 mg/kg,相对标准偏差为1.1%~3.8%,回收率为93.3%~104.0%.结论 本方法灵敏、准确,操作简便、快速,对样品的测定结果与石墨炉原子吸收光度法之间无显著性差异,能用于食品中铅的准确测定.

  12. Reaction mechanism study of 7Li(7Li, 6He) reaction at above Coulomb barrier energies

    V V Parkar; V Jha; S Santra; B J Roy; K Ramachandran; A Shrivastava; K Mahata; A Chatterjee; S Kailas


    The elastic scattering and the 6He angular distributions were measured in 7Li + 7Li reaction at two energies, lab = 20 and 25 MeV. FRDWBA calculations have been performed to explain the measured 6He data. The calculations were very sensitive to the choice of the optical model potentials in entrance and exit channels. The one-step proton transfer was found to be the dominant reaction mechanism in 6He production.

  13. Changing water affinity from hydrophobic to hydrophilic in hydrophobic channels.

    Ohba, Tomonori; Yamamoto, Shotaro; Kodaira, Tetsuya; Hata, Kenji


    The behavior of water at hydrophobic interfaces can play a significant role in determining chemical reaction outcomes and physical properties. Carbon nanotubes and aluminophosphate materials have one-dimensional hydrophobic channels, which are entirely surrounded by hydrophobic interfaces. Unique water behavior was observed in such hydrophobic channels. In this article, changes in the water affinity in one-dimensional hydrophobic channels were assessed using water vapor adsorption isotherms at 303 K and grand canonical Monte Carlo simulations. Hydrophobic behavior of water adsorbed in channels wider than 3 nm was observed for both adsorption and desorption processes, owing to the hydrophobic environment. However, water showed hydrophilic properties in both adsorption and desorption processes in channels narrower than 1 nm. In intermediate-sized channels, the hydrophobic properties of water during the adsorption process were seen to transition to hydrophilic behavior during the desorption process. Hydrophilic properties in the narrow channels for both adsorption and desorption processes are a result of the relatively strong water-channel interactions (10-15 kJ mol(-1)). In the 2-3 nm channels, the water-channel interaction energy of 4-5 kJ mol(-1) was comparable to the thermal translational energy. The cohesive water interaction was approximately 35 kJ mol(-1), which was larger than the others. Thus, the water affinity change in the 2-3 nm channels for the adsorption and desorption processes was attributed to weak water-channel interactions and strong cohesive interactions. These results are inherently important to control the properties of water in hydrophobic environments.

  14. Channelization of plumes beneath ice shelves

    Dallaston, M. C.


    © 2015 Cambridge University Press. We study a simplified model of ice-ocean interaction beneath a floating ice shelf, and investigate the possibility for channels to form in the ice shelf base due to spatial variations in conditions at the grounding line. The model combines an extensional thin-film description of viscous ice flow in the shelf, with melting at its base driven by a turbulent ocean plume. Small transverse perturbations to the one-dimensional steady state are considered, driven either by ice thickness or subglacial discharge variations across the grounding line. Either forcing leads to the growth of channels downstream, with melting driven by locally enhanced ocean velocities, and thus heat transfer. Narrow channels are smoothed out due to turbulent mixing in the ocean plume, leading to a preferred wavelength for channel growth. In the absence of perturbations at the grounding line, linear stability analysis suggests that the one-dimensional state is stable to initial perturbations, chiefly due to the background ice advection.

  15. Calcium channel as a potential anticancer agent.

    Kriazhev, L


    Anticancer treatment in modern clinical practices includes chemotherapy and radiation therapy with or without surgical interventions. Efficiency of both methods varies greatly depending on cancer types and stages. Besides, chemo- and radiotherapy are toxic and damaging that causes serious side effects. This fact prompts the search for alternative methods of antitumor therapy. It is well known that prolonged or high increase of intracellular calcium concentration inevitably leads to the cell death via apoptosis or necrosis. However, stimulation of cell calcium level by chemical agents is hardly achievable because cells have very sophisticated machinery for maintaining intracellular calcium in physiological ranges. This obstacle can be overridden, nevertheless. It was found that calcium channels in so called calcium cells in land snails are directly regulated by extracellular calcium concentration. The higher the concentration the higher the calcium intake is through the channels. Bearing in mind that extracellular/intracellular calcium concentration ratio in human beings is 10,000-12,000 fold the insertion of the channel into cancer cells would lead to fast and uncontrollable by the cells calcium intake and cell death. Proteins composing the channel may be extracted from plasma membrane of calcium cells and sequenced by mass-spectrometry or N-terminal sequencing. Either proteins or corresponding genes could be used for targeted delivery into cancer cells.

  16. Quantum transport with two interacting conduction channels.

    White, Alexander J; Migliore, Agostino; Galperin, Michael; Nitzan, Abraham


    The transport properties of a conduction junction model characterized by two mutually coupled channels that strongly differ in their couplings to the leads are investigated. Models of this type describe molecular redox junctions (where a level that is weakly coupled to the leads controls the molecular charge, while a strongly coupled one dominates the molecular conduction), and electron counting devices in which the current in a point contact is sensitive to the charging state of a nearby quantum dot. Here we consider the case where transport in the strongly coupled channel has to be described quantum mechanically (covering the full range between sequential tunneling and co-tunneling), while conduction through the weakly coupled channel is a sequential process that could by itself be described by a simple master equation. We compare the result of a full quantum calculation based on the pseudoparticle non-equilibrium Green function method to that obtained from an approximate mixed quantum-classical calculation, where correlations between the channels are taken into account through either the averaged rates or the averaged energy. We find, for the steady state current, that the approximation based on the averaged rates works well in most of the voltage regime, with marked deviations from the full quantum results only at the threshold for charging the weekly coupled level. These deviations are important for accurate description of the negative differential conduction behavior that often characterizes redox molecular junctions in the neighborhood of this threshold.

  17. Stochastic resonance in Gaussian quantum channels

    Lupo, Cosmo; Mancini, Stefano; Wilde, Mark M.


    We determine conditions for the presence of stochastic resonance in a lossy bosonic channel with a nonlinear, threshold decoding. The stochastic resonance effect occurs if and only if the detection threshold is outside of a ‘forbidden interval’. We show that it takes place in different settings: when transmitting classical messages through a lossy bosonic channel, when transmitting over an entanglement-assisted lossy bosonic channel and when discriminating channels with different loss parameters. Moreover, we consider a setting in which stochastic resonance occurs in the transmission of a qubit over a lossy bosonic channel with a particular encoding and decoding. In all cases, we assume the addition of Gaussian noise to the signal and show that it does not matter who, between sender and receiver, introduces such a noise. Remarkably, different results are obtained when considering a setting for private communication. In this case, the symmetry between sender and receiver is broken and the ‘forbidden interval’ may vanish, leading to the occurrence of stochastic resonance effects for any value of the detection threshold.

  18. Dendritic potassium channels in hippocampal pyramidal neurons.

    Johnston, D; Hoffman, D A; Magee, J C; Poolos, N P; Watanabe, S; Colbert, C M; Migliore, M


    Potassium channels located in the dendrites of hippocampal CA1 pyramidal neurons control the shape and amplitude of back-propagating action potentials, the amplitude of excitatory postsynaptic potentials and dendritic excitability. Non-uniform gradients in the distribution of potassium channels in the dendrites make the dendritic electrical properties markedly different from those found in the soma. For example, the influence of a fast, calcium-dependent potassium current on action potential repolarization is progressively reduced in the first 150 micrometer of the apical dendrites, so that action potentials recorded farther than 200 micrometer from the soma have no fast after-hyperpolarization and are wider than those in the soma. The peak amplitude of back-propagating action potentials is also progressively reduced in the dendrites because of the increasing density of a transient potassium channel with distance from the soma. The activation of this channel can be reduced by the activity of a number of protein kinases as well as by prior depolarization. The depolarization from excitatory postsynaptic potentials (EPSPs) can inactivate these A-type K+ channels and thus lead to an increase in the amplitude of dendritic action potentials, provided the EPSP and the action potentials occur within the appropriate time window. This time window could be in the order of 15 ms and may play a role in long-term potentiation induced by pairing EPSPs and back-propagating action potentials.

  19. Results of Nucleon Resonance Extraction via Dynamical Coupled-Channels Analysis from Collaboration @ EBAC

    Hiroyuki Kamano


    We review a global analysis of meson production reactions off the nucleons by a collaboration at Excited Baryon Analysis Center of Jefferson Lab. The analysis is pursued with a dynamical coupled-channels approach, within which the dynamics of multi-channel reaction processes are taken into account in a fully consistent way with the two-body as well as three-body unitarity of the S-matrix. With this approach, new features of nucleon excitations are revealed as resonant particles originating from the non-trivial multi-channel reaction dynamics, which cannot be addressed by static hadron models where the nucleon excitations are treated as stable particles.

  20. Poster 3: Anion-molecule reactions in Titan's atmsophere: a laboratory perspective

    Biennier, Ludovic; Joalland, Baptiste; Jamal-Eddine, Nour; Carles, Sophie; Guillemin, Jean-Claude; Trolez, Yann


    Heavy ions discovered in the upper atmosphere of Titan may play some role in the production of aerosols observed at lower altitudes. The composition of the large ions and molecules found in the ionosphere, and their precise formation mechanisms are still largely unknown. This lack of information includes the first steps leading to the production of these species, which govern the growth rate. In particular, negative ion cold chemistry has not been explored systematically. There have been a number of experimental studies conducted to determine the kinetics of anion-neutral reactions, but a fraction only has simultaneously led to the determination of the nature of products and even less to the branching ratio into the different exit channels. In the laboratory, we recently engaged in kinetics studies of anion-molecule reactions starting with the reaction of CN- and C3N- with cyanoacetylene HC3N over the 50-300 K temperature range using the CRESU technique (French acronym standing for Reaction Kinetics in Uniform Supersonic Flow). The results show that the CN- + HC3N reaction contributes directly to the growth of larger anions whereas CN- + HC3N does not. The investigation was recently extended in the laboratory to larger ions and other polar co-reactants. The development of a versatile selected anion source, to be combined with the CRESU apparatus, will be also presented.

  1. Dequantization Via Quantum Channels

    Andersson, Andreas


    For a unital completely positive map {Φ} ("quantum channel") governing the time propagation of a quantum system, the Stinespring representation gives an enlarged system evolving unitarily. We argue that the Stinespring representations of each power {Φ^m} of the single map together encode the structure of the original quantum channel and provide an interaction-dependent model for the bath. The same bath model gives a "classical limit" at infinite time {mto∞} in the form of a noncommutative "manifold" determined by the channel. In this way, a simplified analysis of the system can be performed by making the large- m approximation. These constructions are based on a noncommutative generalization of Berezin quantization. The latter is shown to involve very fundamental aspects of quantum-information theory, which are thereby put in a completely new light.

  2. Chaos in quantum channels

    Hosur, Pavan; Roberts, Daniel A; Yoshida, Beni


    We study chaos and scrambling in unitary channels by considering their entanglement properties as states. Using out-of-time-order correlation functions to diagnose chaos, we characterize the ability of a channel to process quantum information. We show that the generic decay of such correlators implies that any input subsystem must have near vanishing mutual information with almost all partitions of the output. Additionally, we propose the negativity of the tripartite information of the channel as a general diagnostic of scrambling. This measures the delocalization of information and is closely related to the decay of out-of-time-order correlators. We back up our results with numerics in two non-integrable models and analytic results in a perfect tensor network model of chaotic time evolution. These results show that the butterfly effect in quantum systems implies the information-theoretic definition of scrambling.

  3. Chaos in quantum channels

    Hosur, Pavan; Qi, Xiao-Liang [Department of Physics, Stanford University,476 Lomita Mall, Stanford, California 94305 (United States); Roberts, Daniel A. [Center for Theoretical Physics and Department of Physics, Massachusetts Institute of Technology,77 Massachusetts Ave, Cambridge, Massachusetts 02139 (United States); Yoshida, Beni [Perimeter Institute for Theoretical Physics,31 Caroline Street North, Waterloo, Ontario N2L 2Y5 (Canada); Walter Burke Institute for Theoretical Physics, California Institute of Technology,1200 E California Blvd, Pasadena CA 91125 (United States)


    We study chaos and scrambling in unitary channels by considering their entanglement properties as states. Using out-of-time-order correlation functions to diagnose chaos, we characterize the ability of a channel to process quantum information. We show that the generic decay of such correlators implies that any input subsystem must have near vanishing mutual information with almost all partitions of the output. Additionally, we propose the negativity of the tripartite information of the channel as a general diagnostic of scrambling. This measures the delocalization of information and is closely related to the decay of out-of-time-order correlators. We back up our results with numerics in two non-integrable models and analytic results in a perfect tensor network model of chaotic time evolution. These results show that the butterfly effect in quantum systems implies the information-theoretic definition of scrambling.

  4. TRP channels and pain.

    Julius, David


    Nociception is the process whereby primary afferent nerve fibers of the somatosensory system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have served as powerful pharmacological tools for identifying molecules and mechanisms underlying this initial step of pain sensation. These natural products have revealed three members of the transient receptor potential (TRP) ion channel family--TRPV1, TRPM8, and TRPA1--as molecular detectors of thermal and chemical stimuli that activate sensory neurons to produce acute or persistent pain. Analysis of TRP channel function and expression has validated the existence of nociceptors as a specialized group of somatosensory neurons devoted to the detection of noxious stimuli. These studies are also providing insight into the coding logic of nociception and how specification of nociceptor subtypes underlies behavioral discrimination of noxious thermal, chemical, and mechanical stimuli. Biophysical and pharmacological characterization of these channels has provided the intellectual and technical foundation for developing new classes of analgesic drugs.


    Zhao Zheng; Jia Ying; Yin Qinye


    Delay diversity is an effective transmit diversity technique to combat adverse ef-fects of fading. Thus far, previous work in delay diversity assumed that perfect estimates ofcurrent channel fading conditions are available at the receiver and training symbols are requiredto estimate the channel from the transmitter to the receiver. However, increasing the number ofthe antennas increases the required training interval and reduces the available time within whichdata may be transmitted. Learning the channel coefficients becomes increasingly difficult for thefrequency selective channels. In this paper, with the subspace method and the delay character ofdelay diversity, a channel estimation method is proposed, which does not use training symbols. Itaddresses the transmit diversity for a frequency selective channel from a single carrier perspectivein the form of a simple equivalent fiat fading model. Monte Carlo simulations give the perfor-mance of channel estimation and the performance comparison of our channel-estimation-baseddetector with decision feedback equalization, which uses the perfect channel information.

  6. K(v)7 channels: function, pharmacology and channel modulators.

    Dalby-Brown, William; Hansen, Henrik H; Korsgaard, Mads P G; Mirza, Naheed; Olesen, Søren-P


    K(v)7 channels are unique among K(+) channels, since four out of the five channel subtypes have well-documented roles in the development of human diseases. They have distinct physiological functions in the heart and in the nervous system, which can be ascribed to their voltage-gating properties. The K(v)7 channels also lend themselves to pharmacological modulation, and synthetic openers as well as blockers of the channels, regulating neuronal excitability, have existed even before the K(v)7 channels were identified by cloning. In the present review we give an account on the focused efforts to develop selective modulators, openers as well as blockers, of the K(v)7 channel subtypes, which have been undertaken during recent years, along with a discussion of the K(v)7 ion channel physiology and therapeutic indications for modulators of the neuronal K(v)7 channels.

  7. Secondary Lead Enterprise “Lived A Painful Life”


    "Living a painful life."Such is the description given by Wang Hongmei,researcher of the Chinese Research Academy of Environmental Sciences,to the current secondary lead enterprises.Problems like chaotic waste lead acid battery recycling channels,and proliferating illegal smelting despite banning efforts have troubled the secondary lead industry for a long time.In the second half of2015,due to VAT policy adjustment,tax rebate

  8. Ionic Channels in Thunderclouds

    Losseva, T. V.; Fomenko, A. S.; Nemtchinov, I. V.


    We proceed to study the formation and propagation of ionic channels in thunderclouds in the framework of the model of the corona discharge wave propagation (Fomenko A.S., Losseva T.V., Nemtchinov I.V. The corona discharge waves in thunderclouds and formation of ionic channels // 2004 Fall Meeting. EOS Trans. AGU. 2004. V. 85. ¹ 47. Suppl. Abstract AE23A-0835.). In this model we proposed a hypothesis that the structure of a thundercloud becomes nonuniform due to corona discharge on the drops and ice particles and formation of ionic channels with higher conductivity than the surrounding air. When the onset strength of corona discharge becomes smaller than the electric field strength the corona discharge increases concentrations of ions in a small part of the cloud (a hot spot). An additional charge at opposite ends of the hot spot forms due to polarization process. The increased electric field initiates corona discharge in other parts of the cloud on ice particles and water drops with smaller sizes. The corona discharge front moves as a wave with the velocity of the order of ion drift and formes a highly conductive channel. We model this non-stationary problem with Poisson equation which is solved simultaneously with a simplified set of kinetic equations for ions, small charged particles and electrons (at high electric fields), including ionization due to electronic impact, attachment and formation of positive ions. By applying 3D numerical simulations we obtain the parameters of formed ionic channels with respect to onset electric fields both from large particles (in hot spot) and from small particles (surrounding hot spot), microscopic currents from particles with different sizes and the external electric field in the cloud. The interaction of ionic channels is also investigated. This work was supported by Russian Foundation of Basic Research (Project No 07-05-00998-à).

  9. Low-energy electron-induced reactions in thin films of glucose and N-acetyl-glucosamine

    Ryzhkova, A.; Swiderek, P.


    Reactions induced in thin films of α- D-glucose and N-acetylglucosamine by low-energy electron exposure at incident electron energies ( E0) between 5 eV and 15 eV have been investigated by high-resolution electron energy loss spectroscopy (HREELS). The reactions of α- D-glucose upon electron exposure were also studied in the presence of molecular oxygen. Electron exposure leads to characteristic changes of the vibrational spectra indicating that OH groups are lost with the formation of CC double bonds taking place preferentially above the ionisation threshold of the investigated molecules. At lower E0, OH groups are equally decomposed suggesting that dissociative electron attachment contributes to the reactions but formation of double bonds is not observed. The results show that different reaction channels are effective depending on E0 and that the outcome of electron-driven chemistry in saccharides may be controlled by changing from the subionisation regime to E0 above the ionisation threshold. Generally, low-energy electron exposure in the absence of O 2 produces a material with lower oxygen content, i.e. leads to a reduction of the saccharide. In the case of N-acetylglucosamine, removal of the amide group from the sugar is also important at subionisation energies. In contrast, as shown for α- D-glucose, low-energy electron exposure in the presence of O 2 leads to oxidation of the sugar even at cryogenic temperature.

  10. Calcium binding protein-mediated regulation of voltage-gated calcium channels linked to human diseases

    Nasrin NFJATBAKHSH; Zhong-ping FENG


    Calcium ion entry through voltage-gated calcium channels is essential for cellular signalling in a wide variety of cells and multiple physiological processes. Perturbations of voltage-gated calcium channel function can lead to pathophysiological consequences. Calcium binding proteins serve as calcium sensors and regulate the calcium channel properties via feedback mechanisms. This review highlights the current evidences of calcium binding protein-mediated channel regulation in human diseases.

  11. (n,2n) and (n,3n) cross sections of neutron-induced reactions on 150Sm for En from threshold to 35 MeV

    Dashdorj, D; Mitchell, G; Kawano, T; Becker, J; Wu, C; Devlin, M; Fotiades, N; Nelson, R; Kunieda, S


    Cross-section measurements were made of prompt discrete {gamma}-ray production as a function of incident neutron energy (E{sub n} = 1 to 35 MeV) on a {sup 150}Sm sample fo 1550 mg/cm{sup 2} of Sm{sub 2}O{sub 3} enriched to 95.6% in {sup 150}Sm. Results are compared with enhanced Hauser-Feshbach model calculations including the pre-equilibrium reactions. Energetic neutrons were delivered by the Los Alamos Neutron Science Center facility. The prompt-reaction {gamma} rays were detected with the Compton-suppressed Germanium Array for Neutron Induced Excitations (GEANIE). Incident neutron energies were determined by the time-of-flight technique. Excitation functions for thirteen individual {gamma}-rays up to E{sub x} = 0.8 MeV in {sup 149}Sm and one {gamma}-ray transition between the first excited and ground state in {sup 148}Sm were measured. Partial {gamma}-ray cross sections were calculated using GNASH, an enhanced Hauser-Feshbach statistical nuclear reaction model code, and compared with the experimental results. The particle transmission coefficients were calculated with new systematic 'global' optical model potential parameters. The coupled-channel optical model based on the soft rotor model was employed to calculate the particle transmission coefficients. The pre-equilibrium part of the spin distribution in {sup 150}Sm was calculated using the quantum mechanical theory of Feshbach, Kerman, and Koonin (FKK) and incorporated into the GNASH reaction model code. the partial cross sections for discrete {gamma}-ray cascade paths leading to the ground state in {sup 149}Sm and {sup 148}Sm have been summed (without double counting) to estimate lower limits for reaction cross sections. These lower limits are combined with Hauser-Feshbach model calculations to deduce the reaction channel cross sections. These reaction channel cross sections agree with previously measured experimental and ENDF/B-VII evaluations.

  12. Molecular cell biology of KATP channels: implications for neonatal diabetes.

    Smith, Andrew J; Taneja, Tarvinder K; Mankouri, Jamel; Sivaprasadarao, Asipu


    ATP-sensitive potassium (KATP) channels play a key role in the regulation of insulin secretion by coupling glucose metabolism to the electrical activity of pancreatic beta-cells. To generate an electric signal of suitable magnitude, the plasma membrane of the beta-cell must contain an appropriate number of channels. An inadequate number of channels can lead to congenital hyperinsulinism, whereas an excess of channels can result in the opposite condition, neonatal diabetes. KATP channels are made up of four subunits each of Kir6.2 and the sulphonylurea receptor (SUR1), encoded by the genes KCNJ11 and ABCC8, respectively. Following synthesis, the subunits must assemble into an octameric complex to be able to exit the endoplasmic reticulum and reach the plasma membrane. While this biosynthetic pathway ensures supply of channels to the cell surface, an opposite pathway, involving clathrin-mediated endocytosis, removes channels back into the cell. The balance between these two processes, perhaps in conjunction with endocytic recycling, would dictate the channel density at the cell membrane. In this review, we discuss the molecular signals that contribute to this balance, and how an imbalance could lead to a disease state such as neonatal diabetes.

  13. Communicating Under Channel Uncertainty

    Warsi, Naqueeb; Shah, Tapan


    For a single transmit and receive antenna system, a new constellation design is proposed to combat errors in the phase estimate of the channel coefficient. The proposed constellation is a combination of PSK and PAM constellations, where PSK is used to provide protection against phase errors, while PAM is used to increase the transmission rate using the knowledge of the magnitude of the channel coefficient. The performance of the proposed constellation is shown to be significantly better than the widely used QAM in terms of probability of error. The proposed strategy can also be extended to systems using multiple transmit and receive antennas.

  14. Investigation of the influence of incomplete fusion on complete fusion of 16O induced reactions at moderate excitation energies

    Ahamad Tauseef


    Full Text Available An attempt has been made to investigate for the reaction dynamics leading to incomplete fusion (ICF of heavy ions at moderate excitation energies, especially the influence of incomplete fusion on complete fusion (CF of 16O induced reactions at specific energies. Excitation functions (EFs of various reaction products populated via CF and/or ICF of 16O projectile with 45Sc target were measured at energies ≈3-7 MeV/nucleon, using recoil catcher technique followed by offline γ-ray spectroscopy. The measured EFs were compared with theoretical values obtained using the statistical model code PACE4. The experimentally measured EFs were in general found to be in good agreement with the theoretical predictions for non α-emitting channels in the present target projectile system. However, for α-emitting channels the measured EFs were higher than the predictions of the theoretical model codes, which may be credited to incomplete fusion reactions at these energies.

  15. Lead toxicity: Current concerns

    Goyer, R.A. (Univ. of Western Ontario, London (Canada))


    Over the 20-year period since the first issue of Environmental Health Perspectives was published, there has been considerable progress in the understanding of the potential toxicity of exposure to lead. Many of these advances have been reviewed in published symposia, conferences, and review papers in EHP. This brief review identifies major advances as well as a number of current concerns that present opportunities for prevention and intervention strategies. The major scientific advance has been the demonstration that blood lead (PbB) levels of 10-15 micrograms/dL in newborn and very young infants result in cognitive and behavioral deficits. Further support for this observation is being obtained by prospective or longitudinal studies presently in progress. The mechanism(s) for the central nervous system effects of lead is unclear but involve lead interactions within calcium-mediated intracellular messenger systems and neurotransmission. Effects of low-level lead exposure on blood pressure, particularly in adult men, may be related to the effect of lead on calcium-mediated control of vascular smooth muscle contraction and on the renin-angiotensin system. Reproductive effects of lead have long been suspected, but low-level effects have not been well studied. Whether lead is a carcinogen or its association with renal adenocarcinoma is a consequence of cystic nephropathy is uncertain. Major risk factors for lead toxicity in children in the United States include nutrition, particularly deficiencies of essential metals, calcium, iron, and zinc, and housing and socioeconomic status. A goal for the year 2000 is to reduce prevalence of blood lead levels exceeding 15 micrograms/dL. 97 refs.

  16. Reaction of Projectiles with Targets during Hypervelocity Impact

    Russell, Rod; Bless, Stephan; Persad, Chadee; Manthiram, Karthish


    Hollow tungsten projectiles were filled with bismuth oxide or copper and shot into aluminum blocks at 2200 m/s. The blocks were cut open, and the contents and morphology of the penetration channels were examined. In the case of copper fill, the channel was found to be filled with a black foam containing closed-cell bubbles. X-ray diffraction revealed the presence of CuAl2, indicating reaction with the aluminum target. In the case of bismuth oxide, there was little foam, but the penetration channel walls had many craters, which contained nodules of bismuth metal, again indicating reaction with the target. There were variations in crater diameter apparently corresponding to the onset and termination of the reactions. The exothermic nature of the reactions produced cracks in the target blocks.

  17. The tenth annual Ion Channel Retreat, Vancouver, Canada, June 25-27, 2012.

    Kimlicka, Lynn; Jamieson, Ashley Lauren; Liang, Sophia; Brugger, Saranna; Liang, Dong


    Ten years after Aurora Biomed (Vancouver, British Columbia, Canada) hosted the inaugural Ion Channel Retreat, this event is recognized as a leading conference for ion channel researchers. Held annually in Vancouver, this meeting consistently provides an outlet for researchers to share their findings while learning about new concepts, methods, and technologies. Researchers use this forum to discuss and debate a spectrum of topics from ion channel research and technology to drug discovery and safety. The Retreat covered key subjects in the ion channel industry, including ion channels as disease targets, transient receptor protein channels as pain and disease targets, ion channels as pain targets, ion channel structure and function, ion channel screening technologies, cardiac safety and toxicology, and cardiac function and pharmacology.

  18. Computational Fluid Dynamics Study of Channel Geometric Effect for Fischer-Tropsch Microchannel Reactor

    Na, Jonggeol; Jung, Ikhwan; Kshetrimayum, Krishnadash S.; Park, Seongho; Park, Chansaem; Han, Chonghun [Seoul National University, Seoul (Korea, Republic of)


    Driven by both environmental and economic reasons, the development of small to medium scale GTL(gas-to-liquid) process for offshore applications and for utilizing other stranded or associated gas has recently been studied increasingly. Microchannel GTL reactors have been preferred over the conventional GTL reactors for such applications, due to its compactness, and additional advantages of small heat and mass transfer distance desired for high heat transfer performance and reactor conversion. In this work, multi-microchannel reactor was simulated by using commercial CFD code, ANSYS FLUENT, to study the geometric effect of the microchannels on the heat transfer phenomena. A heat generation curve was first calculated by modeling a Fischer-Tropsch reaction in a single-microchannel reactor model using Matlab-ASPEN integration platform. The calculated heat generation curve was implemented to the CFD model. Four design variables based on the microchannel geometry namely coolant channel width, coolant channel height, coolant channel to process channel distance, and coolant channel to coolant channel distance, were selected for calculating three dependent variables namely, heat flux, maximum temperature of coolant channel, and maximum temperature of process channel. The simulation results were visualized to understand the effects of the design variables on the dependent variables. Heat flux and maximum temperature of cooling channel and process channel were found to be increasing when coolant channel width and height were decreased. Coolant channel to process channel distance was found to have no effect on the heat transfer phenomena. Finally, total heat flux was found to be increasing and maximum coolant channel temperature to be decreasing when coolant channel to coolant channel distance was decreased. Using the qualitative trend revealed from the present study, an appropriate process channel and coolant channel geometry along with the distance between the adjacent

  19. Drug hypersensitivity reactions involving skin.

    Hausmann, Oliver; Schnyder, Benno; Pichler, Werner J


    Immune reactions to drugs can cause a variety of diseases involving the skin, liver, kidney, lungs, and other organs. Beside immediate, IgE-mediated reactions of varying degrees (urticaria to anaphylactic shock), many drug hypersensitivity reactions appear delayed, namely hours to days after starting drug treatment, showing a variety of clinical manifestations from solely skin involvement to fulminant systemic diseases which may be fatal. Immunohistochemical and functional studies of drug-specific T cells in patients with delayed reactions confirmed a predominant role for T cells in the onset and maintenance of immune-mediated delayed drug hypersensitivity reactions (type IV reactions). In these reactions, drug-specific CD4+ and CD8+ T cells are stimulated by drugs through their T cell receptors (TCR). Drugs can stimulate T cells in two ways: they can act as haptens and bind covalently to larger protein structures (hapten-carrier model), inducing a specific immune response. In addition, they may accidentally bind in a labile, noncovalent way to a particular TCR of the whole TCR repertoire and possibly also major histocompatibility complex (MHC)-molecules - similar to their pharmacologic action. This seems to be sufficient to reactivate certain, probably in vivo preactivated T cells, if an additional interaction of the drug-stimulated TCR with MHC molecules occurs. The mechanism was named pharmacological interaction of a drug with (immune) receptor and thus termed the p-i concept. This new concept may explain the frequent skin symptoms in drug hypersensitivity to oral or parenteral drugs. Furthermore, the various clinical manifestations of T cell-mediated drug hypersensitivity may be explained by distinct T cell functions leading to different clinical phenotypes. These data allowed a subclassification of the delayed hypersensitivity reactions (type IV) into T cell reactions which, by releasing certain cytokines and chemokines, preferentially activate and recruit

  20. The continuum discretized coupled-channels method and its applications

    Yahiro, Masanobu; Matsumoto, Takuma; Minomo, Kosho


    This is a review on recent developments of the continuum discretized coupled-channels method (CDCC) and its applications to nuclear physics, cosmology and astrophysics, and nuclear engineering. The theoretical foundation of CDCC is shown, and a microscopic reaction theory for nucleus-nucleus scattering is constructed as an underlying theory of CDCC. CDCC is then extended to treat Coulomb breakup and four-body breakup. We also propose a new theory that makes CDCC applicable to inclusive reactions