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Sample records for reach sufficiently high

  1. LHC Report: reaching high intensity

    CERN Multimedia

    Jan Uythoven

    2015-01-01

    After both beams having been ramped to their full energy of 6.5 TeV, the last two weeks saw the beam commissioning process advancing on many fronts. An important milestone was achieved when operators succeeded in circulating a nominal-intensity bunch. During the operation, some sudden beam losses resulted in beam dumps at top energy, a problem that needed to be understood and resolved.   In 2015 the LHC will be circulating around 2800 bunches in each beam and each bunch will contain just over 1 x 1011 protons. Until a few days ago commissioning was taking place with single bunches of 5 x 109 protons. The first nominal bunch with an intensity of 1 x 1011 protons was injected on Tuesday, 21 April. In order to circulate such a high-intensity bunch safely, the whole protection system must be working correctly: collimators, which protect the aperture, are set at preliminary values known as coarse settings; all kicker magnets for injecting and extracting the beams are commissioned with beam an...

  2. Stable dynamics in forced systems with sufficiently high/low forcing frequency.

    Science.gov (United States)

    Bartuccelli, M; Gentile, G; Wright, J A

    2016-08-01

    We consider parametrically forced Hamiltonian systems with one-and-a-half degrees of freedom and study the stability of the dynamics when the frequency of the forcing is relatively high or low. We show that, provided the frequency is sufficiently high, Kolmogorov-Arnold-Moser (KAM) theorem may be applied even when the forcing amplitude is far away from the perturbation regime. A similar result is obtained for sufficiently low frequency, but in that case we need the amplitude of the forcing to be not too large; however, we are still able to consider amplitudes which are outside of the perturbation regime. In addition, we find numerically that the dynamics may be stable even when the forcing amplitude is very large, well beyond the range of validity of the analytical results, provided the frequency of the forcing is taken correspondingly low.

  3. High pressure processing reaches the U.S. market

    International Nuclear Information System (INIS)

    Mermelstein, N.H.

    1997-01-01

    The first food product commercially produced by a U.S. company using high-pressure processing has had successful test market results. High-pressure processing permits food to be preserved by subjecting it to pressures in the range of 60,000-100,000 psi for a short time instead of exposing the food to heat, freezing, chemicals, or irradiation. To produce Classic Guacamole, Avomex of Keller, Texas, uses a batch isostatic press to deactivate the enzymes in the avocado and to kill bacteria, obtaining a refrigerated shelf life of over 30 days. The guacamole is then vacuum packed and processed again. The product undergoes no heat treatment and does not contain preservatives, and the high pressure does not affect its texture, color, or taste. Meanwhile, a continuous system for high-pressure processing of pumpable foods is currently being developed by Flow International of Kent, Washington, and will be used for testing and applications work at Oregon State University

  4. Characterizing and Reaching High-Risk Drinkers Using Audience Segmentation

    Science.gov (United States)

    Moss, Howard B.; Kirby, Susan D.; Donodeo, Fred

    2010-01-01

    Background Market or audience segmentation is widely used in social marketing efforts to help planners identify segments of a population to target for tailored program interventions. Market-based segments are typically defined by behaviors, attitudes, knowledge, opinions, or lifestyles. They are more helpful to health communication and marketing planning than epidemiologically-defined groups because market-based segments are similar in respect to how they behave or might react to marketing and communication efforts. However, market segmentation has rarely been used in alcohol research. As an illustration of its utility, we employed commercial data that describes the sociodemographic characteristics of high-risk drinkers as an audience segment; where they tend to live, lifestyles, interests, consumer behaviors, alcohol consumption behaviors, other health-related behaviors, and cultural values. Such information can be extremely valuable in targeting and planning public health campaigns, targeted mailings, prevention interventions and research efforts. Methods We describe the results of a segmentation analysis of those individuals who self-report consuming five or more drinks per drinking episode at least twice in the last 30-days. The study used the proprietary PRIZM™ audience segmentation database merged with Center for Disease Control and Prevention's (CDC) Behavioral Risk Factor Surveillance System (BRFSS) database. The top ten of the 66 PRIZM™ audience segments for this risky drinking pattern are described. For five of these segments we provide additional in-depth details about consumer behavior and the estimates of the market areas where these risky drinkers reside. Results The top ten audience segments (PRIZM clusters) most likely to engage in high-risk drinking are described. The cluster with the highest concentration of binge drinking behavior is referred to as the “Cyber Millenials.” This cluster is characterized as “the nation's tech-savvy singles

  5. Characterizing and reaching high-risk drinkers using audience segmentation.

    Science.gov (United States)

    Moss, Howard B; Kirby, Susan D; Donodeo, Fred

    2009-08-01

    Market or audience segmentation is widely used in social marketing efforts to help planners identify segments of a population to target for tailored program interventions. Market-based segments are typically defined by behaviors, attitudes, knowledge, opinions, or lifestyles. They are more helpful to health communication and marketing planning than epidemiologically defined groups because market-based segments are similar in respect to how they behave or might react to marketing and communication efforts. However, market segmentation has rarely been used in alcohol research. As an illustration of its utility, we employed commercial data that describes the sociodemographic characteristics of high-risk drinkers as an audience segment, including where they tend to live, lifestyles, interests, consumer behaviors, alcohol consumption behaviors, other health-related behaviors, and cultural values. Such information can be extremely valuable in targeting and planning public health campaigns, targeted mailings, prevention interventions, and research efforts. We described the results of a segmentation analysis of those individuals who self-reported to consume 5 or more drinks per drinking episode at least twice in the last 30 days. The study used the proprietary PRIZM (Claritas, Inc., San Diego, CA) audience segmentation database merged with the Center for Disease Control and Prevention's (CDC) Behavioral Risk Factor Surveillance System (BRFSS) database. The top 10 of the 66 PRIZM audience segments for this risky drinking pattern are described. For five of these segments we provided additional in-depth details about consumer behavior and the estimates of the market areas where these risky drinkers resided. The top 10 audience segments (PRIZM clusters) most likely to engage in high-risk drinking are described. The cluster with the highest concentration of binge-drinking behavior is referred to as the "Cyber Millenials." This cluster is characterized as "the nation's tech

  6. An immobilized and highly stabilized self-sufficient monooxygenase as biocatalyst for oxidative biotransformations

    NARCIS (Netherlands)

    Valencia, Daniela; Guillén, Marina; Fürst, Maximilian; Josep, López-Santín; Álvaro, Gregorio

    BACKGROUND The requirement of expensive cofactors that must be efficiently recycled is one of the major factors hindering the wide implementation of industrial biocatalytic oxidation processes. In this research, a sustainable approach based on immobilized self-sufficient Baeyer-Villiger

  7. High spatial validity is not sufficient to elicit voluntary shifts of attention.

    Science.gov (United States)

    Pauszek, Joseph R; Gibson, Bradley S

    2016-10-01

    Previous research suggests that the use of valid symbolic cues is sufficient to elicit voluntary shifts of attention. The present study interpreted this previous research within a broader theoretical context which contends that observers will voluntarily use symbolic cues to orient their attention in space when the temporal costs of using the cues are perceived to be less than the temporal costs of searching without the aid of the cues. In this view, previous research has not addressed the sufficiency of valid symbolic cues, because the temporal cost of using the cues is usually incurred before the target display appears. To address this concern, 70%-valid spatial word cues were presented simultaneously with a search display. In addition, other research suggests that opposing cue-dependent and cue-independent spatial biases may operate in these studies and alter standard measures of orienting. After identifying and controlling these opposing spatial biases, the results of two experiments showed that the word cues did not elicit voluntary shifts of attention when the search task was relatively easy but did when the search task was relatively difficult. Moreover, the findings also showed that voluntary use of the word cues changed over the course of the experiment when the task was difficult, presumably because the temporal cost of searching without the cue lessened as the task got easier with practice. Altogether, the present findings suggested that the factors underlying voluntary control are multifaceted and contextual, and that spatial validity alone is not sufficient to elicit voluntary shifts of attention.

  8. $C^1$ actions on manifolds by lattices in Lie groups with sufficiently high rank

    OpenAIRE

    Damjanovic, Danijela; Zhang, Zhiyuan

    2018-01-01

    In this paper we study Zimmer's conjecture for $C^1$ actions of higher-rank lattices of a connected, semisimple Lie group with finite center on compact manifolds. We show that if the Lie group has no compact factor, and all of whose non-compact factors are of ranks in some sense sufficiently large with respect to the dimension of the manifold, then every $C^1$ action of an irreducible, co-compact lattice has a finite image. As a corollary of our results, for every (uniform or non-uniform) lat...

  9. Reaching High-Need Youth Populations With Evidence-Based Sexual Health Education in California.

    Science.gov (United States)

    Campa, Mary I; Leff, Sarah Z; Tufts, Margaret

    2018-02-01

    To explore the programmatic reach and experience of high-need adolescents who received sexual health education in 3 distinct implementation settings (targeted-prevention settings, traditional schools, and alternative schools) through a statewide sexual health education program. Data are from youth surveys collected between September 2013 and December 2014 in the California Personal Responsibility Education Program. A sample of high-need participants (n = 747) provided data to examine the impact of implementation setting on reach and program experience. Implementation in targeted-prevention settings was equal to or more effective at providing a positive program experience for high-need participants. More than 5 times as many high-need participants were served in targeted-prevention settings compared with traditional schools. Reaching the same number of high-need participants served in targeted-prevention settings over 15 months would take nearly 7 years of programming in traditional schools. To maximize the reach and experience of high-need youth populations receiving sexual health education, state and local agencies should consider the importance of implementation setting. Targeted resources and efforts should be directed toward high-need young people by expanding beyond traditional school settings.

  10. Pattern of beverage intake and milk and dairy products sufficiency among high-school students in Kuwait.

    Science.gov (United States)

    Nassar, M F; AbdelKader, A M; Al-Refaee, F A; Al-Dhafiri, S S

    2014-12-17

    High consumption of soft drinks has been associated with lower intakes of milk and calcium-rich foods and higher body mass index (BMI). This study aimed to explore the pattern of beverage intake among Kuwaiti high-school students. A questionnaire on knowledge, attitudes and practices concerning beverages and milk and dairy products intake was completed by 190 Kuwaiti students aged 16-18 years and BMI was calculated for 181 of them. Intake of sweetened carbonated beverages and to a lesser extent packaged fruit juices affected the sufficiency of milk and dairy products intake among the sample of high-school students in Kuwait. Although BMI was not related to milk and dairy insufficiency, more of the overweight and obese students displayed incorrect practices. Nutritional education of high-school students on the importance of milk and dairy products as well as the hazards of excess sweetened carbonated beverages and packaged juice is recommended to prevent the obesity epidemic prevailing in Kuwait.

  11. Malaria Cases in the U.S. Reach 40-Year High: Information and Guidance for Clinicians

    Centers for Disease Control (CDC) Podcasts

    This podcast is an overview of the Clinician Outreach and Communication Activity (COCA) Call: Malaria Cases in the U.S. Reach 40-Year High: Information and Guidance for Clinicians. The number of malaria cases reported in the United States in 2011 was the largest since 1971, representing a 14 percent increase from 2010 and a 48 percent increase from 2008. A CDC subject matter expert describes malaria prevention strategies aimed at reducing the risk of malaria in travelers, discusses the diagnosis of malaria in patients with suspect malaria, and explains the treatment options for confirmed malaria cases.

  12. High Variability in Cellular Stoichiometry of Carbon, Nitrogen, and Phosphorus Within Classes of Marine Eukaryotic Phytoplankton Under Sufficient Nutrient Conditions.

    Science.gov (United States)

    Garcia, Nathan S; Sexton, Julie; Riggins, Tracey; Brown, Jeff; Lomas, Michael W; Martiny, Adam C

    2018-01-01

    Current hypotheses suggest that cellular elemental stoichiometry of marine eukaryotic phytoplankton such as the ratios of cellular carbon:nitrogen:phosphorus (C:N:P) vary between phylogenetic groups. To investigate how phylogenetic structure, cell volume, growth rate, and temperature interact to affect the cellular elemental stoichiometry of marine eukaryotic phytoplankton, we examined the C:N:P composition in 30 isolates across 7 classes of marine phytoplankton that were grown with a sufficient supply of nutrients and nitrate as the nitrogen source. The isolates covered a wide range in cell volume (5 orders of magnitude), growth rate (temperature (2-24°C). Our analysis indicates that C:N:P is highly variable, with statistical model residuals accounting for over half of the total variance and no relationship between phylogeny and elemental stoichiometry. Furthermore, our data indicated that variability in C:P, N:P, and C:N within Bacillariophyceae (diatoms) was as high as that among all of the isolates that we examined. In addition, a linear statistical model identified a positive relationship between diatom cell volume and C:P and N:P. Among all of the isolates that we examined, the statistical model identified temperature as a significant factor, consistent with the temperature-dependent translation efficiency model, but temperature only explained 5% of the total statistical model variance. While some of our results support data from previous field studies, the high variability of elemental ratios within Bacillariophyceae contradicts previous work that suggests that this cosmopolitan group of microalgae has consistently low C:P and N:P ratios in comparison with other groups.

  13. Global Broadcast Service Reach Back Via Ultra High Frequency Demand Assigned Multiple Access Satellite Communications

    National Research Council Canada - National Science Library

    Arthur, Joseph

    1998-01-01

    .... An integral part of the user pull is the reach back channel. The reach back channel allows users to speciiy the information they need broadcast and tailor the information to meet their mission needs...

  14. Global Broadcast Service Reach Back via Ultra High Frequency Demand Assigned Multiple Satellite Communications

    National Research Council Canada - National Science Library

    Arthur, Joseph

    1998-01-01

    .... An integral part of the user pull is the reach back channel. The reach back channel allows users to specify' the information they need broadcast and tailor the information to meet their mission needs...

  15. Flexible multimode polymer waveguides for high-speed short-reach communication links

    Science.gov (United States)

    Bamiedakis, N.; Shi, F.; Chu, D.; Penty, R. V.; White, I. H.

    2018-02-01

    Multimode polymer waveguides have attracted great interest for use in high-speed short-reach communication links as they can be cost-effectively integrated onto standard PCBs using conventional methods of the electronics industry and provide low loss (30 GHz×m) interconnection. The formation of such waveguides on flexible substrates can further provide flexible low-weight low-thickness interconnects and offer additional freedom in the implementation of high-speed short-reach optical links. These attributes make these flexible waveguides particularly attractive for use in low-cost detachable chip-to-chip links and in environments where weight and shape conformity become important, such as in cars and aircraft. However, the highly-multimoded nature of these waveguides raises important questions about their performance under severe flex due to mode loss and mode coupling. In this work therefore, we investigate the loss, crosstalk and bandwidth performance of such waveguides under out-of plane bending and in-plane twisting under different launch conditions and carry out data transmission tests at 40 Gb/s on a 1 m long spiral flexible waveguide under flexure. Excellent optical transmission characteristics are obtained while robust loss, crosstalk and bandwidth performance are demonstrated under flexure. Error-free (BER<10-12) 40 Gb/s data transmission is achieved over the 1 m long spiral waveguide for a 180° bend with a 4 mm radius. The obtained results demonstrate the excellent optical and mechanical properties of this technology and highlight its potential for use in real-world systems.

  16. Malaria Cases in the U.S. Reach 40-Year High: Information and Guidance for Clinicians

    Centers for Disease Control (CDC) Podcasts

    2014-02-26

    This podcast is an overview of the Clinician Outreach and Communication Activity (COCA) Call: Malaria Cases in the U.S. Reach 40-Year High: Information and Guidance for Clinicians. The number of malaria cases reported in the United States in 2011 was the largest since 1971, representing a 14 percent increase from 2010 and a 48 percent increase from 2008. A CDC subject matter expert describes malaria prevention strategies aimed at reducing the risk of malaria in travelers, discusses the diagnosis of malaria in patients with suspect malaria, and explains the treatment options for confirmed malaria cases.  Created: 2/26/2014 by Center for Global Health (CGH); Malaria Branch; Emergency Risk Communication Branch (ERCB); Office of Public Health Preparedness and Response (OPHPR).   Date Released: 2/26/2014.

  17. In the Dark Shadow of the Supercycle Tailings Failure Risk & Public Liability Reach All Time Highs

    Directory of Open Access Journals (Sweden)

    Lindsay Newland Bowker

    2017-10-01

    Full Text Available This is the third in a series of independent research papers attempting to improve the quality of descriptive data and analysis of tailings facility failures globally focusing on the relative occurrence, severity and root causes of these failures. This paper updates previously published failures data through 2010 with both additional data pre-2010 and additional data 2010–2015. All three papers have explored the connection between high public consequence failure trends and mining economics trends especially grade, costs to produce and price. This work, the third paper, looks more deeply at that connection through several autopsies of the dysfunctional economics of the period 2000–2010 in which the greatest and longest price increase in recorded history co-occurred across all commodities, a phenomenon sometimes called a supercycle. That high severity failures reached all-time highs in the same decade as prices rose to highs, unprecedented since 1916, challenges many fundamental beliefs and assumptions that have governed modern mining operations, investment decisions, and regulation. It is from waste management in mining, a non-revenue producing cost incurring part of every operation, that virtually all severe environmental and community damages arise. These damages are now more frequently at a scale and of a nature that is non-remediable and beyond any possibility of clean up or reclamation. The authors have jointly undertaken this work in the public interest without funding from the mining industry, regulators, non-governmental organizations, or from any other source.

  18. Intertidal oysters reach their physiological limit in a future high-CO2 world.

    Science.gov (United States)

    Scanes, Elliot; Parker, Laura M; O'Connor, Wayne A; Stapp, Laura S; Ross, Pauline M

    2017-03-01

    Sessile marine molluscs living in the intertidal zone experience periods of internal acidosis when exposed to air (emersion) during low tide. Relative to other marine organisms, molluscs have been identified as vulnerable to future ocean acidification; however, paradoxically it has also been shown that molluscs exposed to high CO 2 environments are more resilient compared with those molluscs naive to CO 2 exposure. Two competing hypotheses were tested using a novel experimental design incorporating tidal simulations to predict the future intertidal limit of oysters in a high-CO 2 world; either high-shore oysters will be more tolerant of elevated P CO 2 because of their regular acidosis, or elevated P CO 2  will cause high-shore oysters to reach their limit. Sydney rock oysters, Saccostrea glomerata , were collected from the high-intertidal and subtidal areas of the shore and exposed in an orthogonal design to either an intertidal or a subtidal treatment at ambient or elevated P CO 2 , and physiological variables were measured. The combined treatment of tidal emersion and elevated P CO 2  interacted synergistically to reduce the haemolymph pH (pH e ) of oysters, and increase the P CO 2  in the haemolymph ( P e,CO 2 ) and standard metabolic rate. Oysters in the intertidal treatment also had lower condition and growth. Oysters showed a high degree of plasticity, and little evidence was found that intertidal oysters were more resilient than subtidal oysters. It is concluded that in a high-CO 2 world the upper vertical limit of oyster distribution on the shore may be reduced. These results suggest that previous studies on intertidal organisms that lacked tidal simulations may have underestimated the effects of elevated P CO 2 . © 2017. Published by The Company of Biologists Ltd.

  19. Probability modeling of high flow extremes in Yingluoxia watershed, the upper reaches of Heihe River basin

    Science.gov (United States)

    Li, Zhanling; Li, Zhanjie; Li, Chengcheng

    2014-05-01

    Probability modeling of hydrological extremes is one of the major research areas in hydrological science. Most basins in humid and semi-humid south and east of China are concerned for probability modeling analysis of high flow extremes. While, for the inland river basin which occupies about 35% of the country area, there is a limited presence of such studies partly due to the limited data availability and a relatively low mean annual flow. The objective of this study is to carry out probability modeling of high flow extremes in the upper reach of Heihe River basin, the second largest inland river basin in China, by using the peak over threshold (POT) method and Generalized Pareto Distribution (GPD), in which the selection of threshold and inherent assumptions for POT series are elaborated in details. For comparison, other widely used probability distributions including generalized extreme value (GEV), Lognormal, Log-logistic and Gamma are employed as well. Maximum likelihood estimate is used for parameter estimations. Daily flow data at Yingluoxia station from 1978 to 2008 are used. Results show that, synthesizing the approaches of mean excess plot, stability features of model parameters, return level plot and the inherent independence assumption of POT series, an optimum threshold of 340m3/s is finally determined for high flow extremes in Yingluoxia watershed. The resulting POT series is proved to be stationary and independent based on Mann-Kendall test, Pettitt test and autocorrelation test. In terms of Kolmogorov-Smirnov test, Anderson-Darling test and several graphical diagnostics such as quantile and cumulative density function plots, GPD provides the best fit to high flow extremes in the study area. The estimated high flows for long return periods demonstrate that, as the return period increasing, the return level estimates are probably more uncertain. The frequency of high flow extremes exhibits a very slight but not significant decreasing trend from 1978 to

  20. Optimization of Silicon MZM Fabrication Parameters for High Speed Short Reach Interconnects at 1310 nm

    Directory of Open Access Journals (Sweden)

    Alexis Abraham

    2016-11-01

    Full Text Available Optical modulators are key components to realize photonic circuits, and Mach-Zehnder modulators (MZM are often used for high speed short reach interconnects. In order to maximize the tolerable path loss of a transmission link at a given bitrate, the MZM needs to be optimized. However, the optimization can be complex since the overall link performance depends on various parameters, and, for the MZM in particular, implies several trade-offs between efficiency, losses, and bandwidth. In this work, we propose a general and rigorous method to optimize silicon MZM. We first describe the optical link, and the numerical method used for this study. Then we present the results associated to the active region for 1310 nm applications. An analytical model is generated, and allows us to quickly optimize the p-n junction depending of the targeted performances for the MZM. Taking into account the required optical link parameters, the maximum tolerable path losses for different length of MZM is determined. By applying this method, simulations show that the optimum MZM length for 25 Gbps applications is 4 mm with an efficiency of 1.87 V·cm, 0.52 dB/mm of losses. A tolerable path loss of more than 25 dB is obtained.

  1. The Remaining Service Time Upon Reaching a High Level in M/G/1 Queues

    NARCIS (Netherlands)

    de Boer, Pieter-Tjerk; Nicola, V.F.; van Ommeren, Jan C.W.

    The distribution of the remaining service time upon reaching some target level in an M/G/1 queue is of theoretical as well as practical interest. In general, this distribution depends on the initial level as well as on the target level, say, B. Two initial levels are of particular interest, namely,

  2. Why is parental lifespan linked to children's chances of reaching a high age? A transgenerational hypothesis.

    Science.gov (United States)

    Vågerö, Denny; Aronsson, Vanda; Modin, Bitte

    2018-04-01

    Transgenerational determinants of longevity are poorly understood. We used data from four linked generations (G0, G1, G2 and G3) of the Uppsala Birth Cohort Multigeneration Study to address this issue. Mortality in G1 (N = 9565) was followed from 1961-2015 and analysed in relation to tertiles of their parents' (G0) age-at-death using Cox regression. Parental social class and marital status were adjusted for in the analyses, as was G1's birth order and adult social class. For an almost entirely deceased segment of G1 (n = 1149), born 1915-1917, we compared exact age-at-death with G0 parents' age-at-death. Finally, we explored 'resilience' as a potentially important mechanism for intergenerational transmission of longevity, using conscript information from psychological interviews of G2 and G3 men. G0 men's and women's ages-at-death were independently associated with G1 midlife and old age mortality. This association was robust and minimally reduced when G0 and G1 social class were adjusted for. We observed an increased lifespan in all social groups. Median difference in age-at-death for sons compared to fathers was + 3.9 years, and + 6.9 years for daughters compared to mothers.Parents' and maternal grandmother's longevity were associated with resilience in subsequent generations. Resilience scores of G2 men were also associated with those of their G3 sons and with their own mortality in midlife. The chance of reaching a high age is transmitted from parents to children in a modest, but robust way. Longevity inheritance is paralleled by the inheritance of individual resilience. Individual resilience, we propose, develops in the first part of life as a response to adversity and early experience in general. This gives rise to a transgenerational pathway, distinct from social class trajectories. A theory of longevity inheritance should bring together previous thinking around general susceptibility, frailty and resilience with new insights from epigenetics and social

  3. Convergent optical wired and wireless long-reach access network using high spectral-efficient modulation.

    Science.gov (United States)

    Chow, C W; Lin, Y H

    2012-04-09

    To provide broadband services in a single and low cost perform, the convergent optical wired and wireless access network is promising. Here, we propose and demonstrate a convergent optical wired and wireless long-reach access networks based on orthogonal wavelength division multiplexing (WDM). Both the baseband signal and the radio-over-fiber (ROF) signal are multiplexed and de-multiplexed in optical domain, hence it is simple and the operation speed is not limited by the electronic bottleneck caused by the digital signal processing (DSP). Error-free de-multiplexing and down-conversion can be achieved for all the signals after 60 km (long-reach) fiber transmission. The scalability of the system for higher bit-rate (60 GHz) is also simulated and discussed.

  4. Coal-tar pitch high temperature (CTPHT), transitional arrangements and way forward under REACH. REACH-SEA report of scoping study

    NARCIS (Netherlands)

    Beekman M; Boersma AHR; Sijm DTHM; SEC

    2009-01-01

    Een beperking of autorisatie binnen de Europese wetgeving REACH is niet de meest geeigende manier om de risico's aan te pakken van PAK-emissies. Deze emissies, die vooral vrijkomen tijdens productie- of verbrandingsprocessen, worden namelijk niet goed ondervangen in deze wetgeving. Dit

  5. Quantifying hyporheic exchange dynamics in a highly regulated large river reach.

    Energy Technology Data Exchange (ETDEWEB)

    Hammond, Glenn Edward; Zhou, T; Huang, M; Hou, Z; Bao, J; Arntzen, E; Mackley, R; Harding, S; Titzler, S; Murray, C; Perkins, W; Chen, X; Stegen, J; Thorne, P; Zachara, J

    2017-03-01

    Hyporheic exchange is an important mechanism taking place in riverbanks and riverbed sediments, where river water and shallow groundwater mix and interact with each other. The direction, magnitude, and residence time of the hyporheic flux that penetrates the river bed are critical for biogeochemical processes such as carbon and nitrogen cycling, and biodegradation of organic contaminants. Many approaches including field measurements and numerical methods have been developed to quantify the hyporheic exchanges in relatively small rivers. However, the spatial and temporal distributions of hyporheic exchanges in a large, regulated river reach remain less explored due to the large spatial domains, complexity of geomorphologic features and subsurface properties, and the great pressure gradient variations at the riverbed created by dam operations.

  6. River reach classification for the Greater Mekong Region at high spatial resolution

    Science.gov (United States)

    Ouellet Dallaire, C.; Lehner, B.

    2014-12-01

    River classifications have been used in river health and ecological assessments as coarse proxies to represent aquatic biodiversity when comprehensive biological and/or species data is unavailable. Currently there are no river classifications or biological data available in a consistent format for the extent of the Greater Mekong Region (GMR; including the Irrawaddy, the Salween, the Chao Praya, the Mekong and the Red River basins). The current project proposes a new river habitat classification for the region, facilitated by the HydroSHEDS (HYDROlogical SHuttle Elevation Derivatives at multiple Scales) database at 500m pixel resolution. The classification project is based on the Global River Classification framework relying on the creation of multiple sub-classifications based on different disciplines. The resulting classes from the sub-classification are later combined into final classes to create a holistic river reach classification. For the GMR, a final habitat classification was created based on three sub-classifications: a hydrological sub-classification based only on discharge indices (river size and flow variability); a physio-climatic sub-classification based on large scale indices of climate and elevation (biomes, ecoregions and elevation); and a geomorphological sub-classification based on local morphology (presence of floodplains, reach gradient and sand transport). Key variables and thresholds were identified in collaboration with local experts to ensure that regional knowledge was included. The final classification is composed 54 unique final classes based on 3 sub-classifications with less than 15 classes each. The resulting classifications are driven by abiotic variables and do not include biological data, but they represent a state-of-the art product based on best available data (mostly global data). The most common river habitat type is the "dry broadleaf, low gradient, very small river". These classifications could be applied in a wide range of

  7. Inhibition of collective spontaneous decay and superradiance in an ensemble of sufficiently high quantity of excited identical atoms

    International Nuclear Information System (INIS)

    Basharov, A.M.

    2011-01-01

    New effects of suppression of the collective spontaneous emission and superradiance have been predicted. At a certain number N of ensemble atoms, the Stark interaction with a vacuum field was shown as being high enough for the excited N-atom ensemble to be stabilized with respect to the collective decay. The result was derived analytically as a consequence of applying the quantum stochastic differential equations to the description of the atomic dynamics in vacuum, where the Stark interaction operator is expressed in terms of the quantum Poisson process. -- Highlights: → Enhancement of the Stark interaction of N atoms ensemble with vacuum, with N rising. → Representation of the Stark interaction as the quantum Poisson process. → Collective spontaneous decay and superradiance under the strong Stark interaction. → Inhibition of superradiance at a certain number of ensemble atoms. → Analysis of superradiance experiments in terms of inhibition of collective decay.

  8. Socio-economic analysis for the authorisation of chemicals under REACH: A case of very high concern?

    NARCIS (Netherlands)

    Gabbert, S.G.M.; Scheringer, M.; Ng, C.A.; Stolzenberg, H.C.

    2014-01-01

    Under the European chemicals’ legislation, REACH, substances that are identified to be of “very high concern” will de facto be removed from the market unless the European Commission grants authorisations permitting specific uses. Companies who apply for an authorisation without demonstrating

  9. Fundamental change of granular flows dynamics, deposition and erosion processes at sufficiently high slope angles: insights from laboratory experiments

    Science.gov (United States)

    Farin, M.; Mangeney, A.; Roche, O.

    2013-12-01

    the granular flows dynamics and deposition. (i) On a rigid bed, as the slow propagation phase lasts longer, the normalized runout distance rf/h0 is greater for a given slope angle and the front of the flow deposit becomes more round. (ii) On an erodible bed, increasing the duration of the slow phase causes the bed excavation to lasts longer and the increase of the runout distance compared with the case on the rigid bed to be greater; this is even more significant as the bed is less compact. For flows on an erodible bed and if the slope angle is high enough, waves of grains appear in the flow head, at the interface between the flow (white) and the bed (black). These waves are related to the erosion/deposition processes at the base of the flow.

  10. A high performance long-reach passive optical network with a novel excess bandwidth distribution scheme

    Science.gov (United States)

    Chao, I.-Fen; Zhang, Tsung-Min

    2015-06-01

    Long-reach passive optical networks (LR-PONs) have been considered to be promising solutions for future access networks. In this paper, we propose a distributed medium access control (MAC) scheme over an advantageous LR-PON network architecture that reroutes the control information from and back to all ONUs through an (N + 1) × (N + 1) star coupler (SC) deployed near the ONUs, thereby overwhelming the extremely long propagation delay problem in LR-PONs. In the network, the control slot is designed to contain all bandwidth requirements of all ONUs and is in-band time-division-multiplexed with a number of data slots within a cycle. In the proposed MAC scheme, a novel profit-weight-based dynamic bandwidth allocation (P-DBA) scheme is presented. The algorithm is designed to efficiently and fairly distribute the amount of excess bandwidth based on a profit value derived from the excess bandwidth usage of each ONU, which resolves the problems of previously reported DBA schemes that are either unfair or inefficient. The simulation results show that the proposed decentralized algorithms exhibit a nearly three-order-of-magnitude improvement in delay performance compared to the centralized algorithms over LR-PONs. Moreover, the newly proposed P-DBA scheme guarantees low delay performance and fairness even when under attack by the malevolent ONU irrespective of traffic loads and burstiness.

  11. High diversity of nitrogen-fixing bacteria in upper reaches of Heihe River, Northwestern China

    Science.gov (United States)

    Tai, X. S.; Mao, W. L.; Liu, G. X.; Chen, T.; Zhang, W.; Wu, X. K.; Long, H. Z.; Zhang, B. G.

    2013-03-01

    Vegetation plays a key role to water conservation in southern Qilian Mountains (Northwestern China), the upper reaches of Heihe River. Nitrogen-fixing bacteria are crucial for vegetation protection because they can supply plants with nitrogen source. Nevertheless, little is known about nitrogen-fixing bacteria in this region. In present study, nifH gene clone libraries were established for detecting the difference of nitrogen-fixing bacterial communities between Potentilla parvifolia shrub and Carex alrofusca meadow in the southern Qilian Mountains. All the identified nitrogen-fixing bacterial clones belonged to Proteobacteria. At the genus level, the Azospirillum sp. was only detected in shrub soil while Thiocapsa sp., Derxiasp., Ectothiorhodospira sp., Mesorhizobium sp., Klebsiella sp., Ensifer sp., Methylocella sp. and Peseudomonas sp. were just detected in meadow soil. Shannon-Wiener index of nifH gene ranged from 1.5 to 2.8 and was higher in meadow soil than shrub soil. Contrarily, the nifH gene copies and CFUs of cultured nitrogen-fixing bacteria ranged from 0.4 × 107 to 6.9 × 107 copies g-1 soil and 0.97 × 106 to 12.78 × 106 g-1 soil, respectively. Furthermore, both of them were lower in meadow soil than shrub soil. Statistical analysis revealed that diversity and copies of nifH gene mostly correlated with aboveground biomass in shrub soil. In meadow soil, nifH gene diversity was principally affected by altitude while copies did by soil available K.

  12. Leading experience of reaching high labor productivity in the stoping face using grader extraction

    Energy Technology Data Exchange (ETDEWEB)

    Chikh, M P

    1982-01-01

    The main factors which hold back highly productive work are high labor intensity of reinforcing the terminal sections of the longwalls, difference in the speed characteristics of the worm and longwall conveyers, jamming of the worm conveyers, holdups in transportation, etc. Consequently under the leadership of the party and trade union organizations, organizational technical measures were developed and are constantly being improved. Shift working meetings are held at which specific solutions are adopted. In order to improve load on the face, specific measures were adopted: measures are regularly developed for maintenance and repair of the stoping face equipment; a cartogram of repair-technical operations is compiled for the longwall; the velocity of the worm conveyers is brought to the velocity of the longwall conveyer, on the scraper conveyers in the conveyer galleries the edge is increased to 0.6 m; supply of electricity to the grader and conveyer in the longwall is done by individual substations; the efficiency experts of the mines have developed and introduced an improved design of belt loader at the loading point; in order to repair equipment on off days, a special group of highly skilled mechanics has been created. Introduction of these measures together will make it possible to improve coal extraction, labor productivity, labor efficiency, reduce accident rate, reveal latent reserves. Practice has indicated that the use of the grader units with mechanized timbering IMKS makes it possible to achieve high technical-economic indicators both of the work of the brigade and the mine as a whole.

  13. Reaching High Altitudes on Mars with an Inflatable Hypersonic Drag Balloon (Ballute)

    CERN Document Server

    Griebel, Hannes

    2010-01-01

    The concept of probing the atmosphere of planet Mars by means of a hypersonic drag balloon, a device known as a “ballute”, is a novel approach to planetary science. In this concept, the probe deploys an inflatable drag body out in space and may then enter the atmosphere either once or several times until it slowly descends towards the ground, taking continuous atmospheric and other readings across a large altitude and ground range. Hannes Griebel discusses the theory behind such a mission along with experience gained during its practical implementation, such as mission design, manufacturing, packing and deployment techniques as well as ground and flight tests. The author also studies other ballute applications, specifically emergency low Earth orbit recovery and delivering payloads to high altitude landing sites on Mars.

  14. Portuguese-language high school teacher programme extends its reach to South America and Africa

    CERN Multimedia

    Carolyn Lee

    2010-01-01

    From 5 to 10 September, a record 75 teachers from Portugal, Brazil, Mozambique, Angola, São Tomé and Cape Verde will take part in the Portuguese-language high school teacher programme at CERN.   The group of Portuguese-sepaking teachers who visited CERN in 2009. CERN usually focuses on the Member States when organizing its national teacher programmes, providing them with additional return on their investment in the Laboratory by helping to train and inspire the next generation of scientists. However, Portugal’s Laboratório de Instrumentação e Física Experimental de Partículas (LIP), through the Agency Ciência Viva, has taken the initiative to go beyond the borders of Portugal and include other countries that speak Portuguese. Last year there were 60 participants in the programme, including 11 teachers from Brazil and 5 from Mozambique. This year brings even more teachers from more African co...

  15. Backwaters in the upper reaches of reservoirs produce high densities of age-0 crappies

    Science.gov (United States)

    Dagel, Jonah D.; Miranda, Leandro E.

    2012-01-01

    Reservoir backwaters are aquatic habitats in floodplains of reservoir tributaries that are permanently or periodically flooded by the reservoir. Like many reservoir arms, backwaters are commonly shallow, littoral habitats, but they differ from arms in various respects, including their support of primarily wetland plant assemblages that are tolerant to flooding. Elsewhere, the reservoir floods mainly upland plants that are less tolerant to flooding, producing a band of barren shoreline along the fluctuation zone. We investigated differences in relative abundance of age-0 crappies Pomoxis spp. in backwaters and arms of widely fluctuating flood control reservoirs, examined the effect of water level, and estimated the likelihood and timing with which these habitats are flooded annually. Higher catch rates of age-0 crappies were obtained in backwater habitats than in arm habitats. When inundated during the crappie spawning season, backwaters provided vegetated habitat at lower water levels than arms. Backwaters flooded earlier than arms and remained flooded longer to provide prolonged nursery habitat. Whereas vegetated habitat was inundated almost yearly in backwaters and arms, inundation that was timed to the onset of spawning occurred less regularly. Because of differences in water elevation, vegetated habitats were flooded in time for crappie spawning about every other year in backwaters but only every third year in arms. Recruitment of age-0 crappies was inversely correlated with high water levels during the months preceding the spawning period, perhaps because early flooding degraded the vegetation. Our results suggest that water levels may be managed during late winter and spring to regularly flood wetland vegetation communities in backwaters; however, water levels should be maintained at or below normal pool and should only irregularly flood upland vegetation in reservoir arms to promote the preservation of such vegetation. Furthermore, management efforts to

  16. Highly Efficient Perovskite-Perovskite Tandem Solar Cells Reaching 80% of the Theoretical Limit in Photovoltage.

    Science.gov (United States)

    Rajagopal, Adharsh; Yang, Zhibin; Jo, Sae Byeok; Braly, Ian L; Liang, Po-Wei; Hillhouse, Hugh W; Jen, Alex K-Y

    2017-09-01

    Organic-inorganic hybrid perovskite multijunction solar cells have immense potential to realize power conversion efficiencies (PCEs) beyond the Shockley-Queisser limit of single-junction solar cells; however, they are limited by large nonideal photovoltage loss (V oc,loss ) in small- and large-bandgap subcells. Here, an integrated approach is utilized to improve the V oc of subcells with optimized bandgaps and fabricate perovskite-perovskite tandem solar cells with small V oc,loss . A fullerene variant, Indene-C 60 bis-adduct, is used to achieve optimized interfacial contact in a small-bandgap (≈1.2 eV) subcell, which facilitates higher quasi-Fermi level splitting, reduces nonradiative recombination, alleviates hysteresis instabilities, and improves V oc to 0.84 V. Compositional engineering of large-bandgap (≈1.8 eV) perovskite is employed to realize a subcell with a transparent top electrode and photostabilized V oc of 1.22 V. The resultant monolithic perovskite-perovskite tandem solar cell shows a high V oc of 1.98 V (approaching 80% of the theoretical limit) and a stabilized PCE of 18.5%. The significantly minimized nonideal V oc,loss is better than state-of-the-art silicon-perovskite tandem solar cells, which highlights the prospects of using perovskite-perovskite tandems for solar-energy generation. It also unlocks opportunities for solar water splitting using hybrid perovskites with solar-to-hydrogen efficiencies beyond 15%. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Successful Reach and Adoption of a workplace health promotion RCT targeting a group of high-risk workers

    Directory of Open Access Journals (Sweden)

    Ekner Dorte

    2010-06-01

    Full Text Available Abstract Background Cleaners are rarely introduced to workplace health promotion programs. The study's objective was to evaluate the reach and adoption of a workplace randomized controlled trial (RCT among cleaners in Denmark. Methods Cleaning businesses with at least 30 employees, that could offer a weekly 1-hour intervention during working hours, were invited to participate. Employees working at least 20 hours/week were invited to answer a screening questionnaire and consent to participate. Analyses determined the differences in health variables between responders and non-responders, consenters and non-consenters, participants and non-participants and between participants of the RCT's three groups: physical coordination training, cognitive-behavioural theory-based training and reference group. Results From 16 eligible workplaces, a representative sample of 50% adopted the trial. Of 758 eligible employees, 78% responded to the screening questionnaire and 49% consented to participate. Consenters and participants differed from non-consenters and non-participants by having higher BMI, more chronic diseases and poorer musculoskeletal health. Conclusions This study indicates that workplace health promotion programs directed at health risk factors among cleaners enable significant adoption and reach to a high-risk subgroup of the Danish workforce. Trial registration Trial registration ISRCTN96241850

  18. Reaching the hard to reach.

    Science.gov (United States)

    Bhiwandi, P; Campbell, M; Potts, M

    1994-01-01

    The 1994 International Conference on Population and Development proposed increasing contraceptive couple protection from 550 million in 1995 to 880 million in 2015. The task for family planning (FP) programs is to provide access to services for, sometimes, inaccessible rural populations. FP need based on desire for no more children has ranged from under 20% in Senegal to almost 80% in Peru. Socioeconomic development was found not to be a prerequisite for fertility change. Gender inequalities in education and social autonomy must be changed. FP access is very important among women with a disadvantaged background or among women unsure about FP. Bangladesh is a good example of a country with increased contraceptive prevalence despite low income. The rule of thumb is that contraception increases of 15% contribute to a drop in family size of about one child. Program effectiveness is related to a variety of factors: contraceptive availability at many locations, acceptable price of contraception, delivery of the oral contraceptives without prescriptions, and other strategies. FP is a service not a medical treatment. A range of methods must be promoted and available from a range of facilities. Contraceptive use is dependent on the woman's stage in her lifecycle and is dependent on informed choice. Community-based distribution systems are effective, whereas free distribution by poorly-trained field workers is not always very effective because patient payment of all or part of the cost assures quality and freedom of choice. Effective programs for underprivileged groups involve aggressive, easy to manage programs that can be replicated rapidly. FP serves a useful function in depressing maternal mortality among the poor in Africa, who have no access to quality health services. Social marketing is an effective strategy for reaching remote areas. Political will and robust management are necessary commodities.

  19. Therapy with high LET Radioisotopes: Can sufficient levels of attractive Auger and alpha emitters be produced to make their use practical?

    International Nuclear Information System (INIS)

    Knapp, F.F. Jr.; Mirzadeh, S.; Stabin, M.; Brill, A.B.

    2005-01-01

    Because of localized energy deposition within a very small volume, cellular targeted therapy with high linear energy transfer (LET) Auger-electron and alpha-particle emitting radioisotopes is of great interest. While the energy deposition from alpha particles usually encompasses several cell diameters, the dose from Auger electrons is confined to a single cell. Two major challenges for broader use of Alpha and Auger emitters are the efficient and cost effective routine production of sufficient levels of these radioisotopes, and the availability of targeting molecules to which the radioisotopes can be attached for cellular delivery of sufficient levels of activity for effective therapy. Examples of several Alpha-and Auger-emitting radioisotopes of current interest are presented. Alpha- and Auger electron-emitting radioisotopes can be produced in accelerators (A) and nuclear reactors (R), and several alpha emitter congeners (i.e. thorium-229) can be obtained from uranium decay products. The challenge for reactor production, is the availability and exploitation of methods - other then the usual radiative (n,γ) production route which will provide no-carrier-added (nca) or the high specific activity radioisotopes of interest. The submitted manuscript has been authored by a contractor of the U.S. Government under contract DE-AC05-00OR22725. Accordingly, the U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for U.S. Government purposes High LET radioisotopes of current interest which are in the initial stages of development and/or which demonstrate practical use in clinical trials include several alpha-emitters, in particular bismuth-213 - and also the actinium-225 parent - astatine-211 and bismuth-212. Extensive experimental studies have been reported with Auger iododeoxyuridine (IdUR) radiolabeled with the iodine-125 emitter-labeled. However, development of production

  20. A mobile and self-sufficient lab for high frequency measurements of stable water isotopes and chemistry of multiple water sources

    Science.gov (United States)

    Windhorst, David; Kraft, Philipp; Holly, Hartmut; Sahraei, Amir; Breuer, Lutz

    2017-04-01

    Technical advances over the last years have made instruments for stable water isotope and water chemistry measurements smaller, more durable and energy efficient. It is nowadays feasible to deploy such instruments in situ during field campaigns. Coupled to an automated sample delivery system, high temporal resolution online measurements of various sources are within the bounds of economic and technical possibility. However, the day to day operation of such equipment still requires either a lot of man power and infrastructure or the implementation of a quasi-self-sufficient system. The challenge remains on how to facilitate and remotely operate such a system. We present the design and implementation of the Water Analysis Trailer for Environmental Research (WATER), an autonomous platform consisting of instruments for stable water isotope and water chemistry analysis. The system takes and measures samples in high temporal resolution (operation of up to one week several issues need to be addressed. The essential topics are: - self-sufficient power supply, - automated sample delivery and preparation, and - autonomous measurements and management interfacing all instruments. In addition to the basic requirements we implemented: - communication of all system states, alarm messages and measurement results to an internal as well as an external database via cellular telemetry, - automated storage of up to 300 frozen reference samples (100 mL, stored at -18°C), - climate control for temperature sensitive equipment (±1°C), - a local and remote (up to 20 km using radio telemetry) sensor network (i.e. to record states of the hydrological system and climate and soil conditions), also suitable to trigger specific measurements - automatic fire suppression and security system. The initial instrumentation includes a UV spectrometer (ProPs, Trios GmBH, Germany) to measure NO3-, COD, TOC and total suspended sediments, multiparameter water quality probe (YSI600R, YSI, USA) to measure

  1. Assessing the role of syringe dispensing machines and mobile van outlets in reaching hard-to-reach and high-risk groups of injecting drug users (IDUs: a review

    Directory of Open Access Journals (Sweden)

    Islam Md Mofizul

    2007-10-01

    Full Text Available Abstract Reaching hard-to-reach and high-risk injecting drug users (IDUs is one of the most important challenges for contemporary needle syringe programs (NSPs. The aim of this review is to examine, based upon the available international experience, the effectiveness of syringe vending machines and mobile van/bus based NSPs in making services more accessible to these hard-to-reach and high-risk groups of IDUs. A literature search revealed 40 papers/reports, of which 18 were on dispensing machines (including vending and exchange machines and 22 on mobile vans. The findings demonstrate that syringe dispensing machines and mobile vans are promising modalities of NSPs, which can make services more accessible to the target group and in particular to the harder-to-reach and higher-risk groups of IDUs. Their anonymous and confidential approaches make services attractive, accessible and acceptable to these groups. These two outlets were found to be complementary to each other and to other modes of NSPs. Services through dispensing machines and mobile vans in strategically important sites are crucial elements in continuing efforts in reducing the spread of HIV and other blood borne viruses among IDUs.

  2. Reaching Out

    Science.gov (United States)

    Moore, John W.

    1999-11-01

    In the United States, National Chemistry Week is November 7-13. (For more NCW information, go to http://www.acs.org/ncw/.) NCW's theme, celebrating polymers, is echoed in this issue (pages 1497-1501, 1512-1513, 1521-1540). Almost certainly there will be chemists in your area spending a great deal of their time on outreach activities for children and the general public during NCW. Chances are good that many Journal readers like you will be among them. And there are probably many more outreach programs that you or your acquaintances lead during the rest of the year. This month of NCW seems an appropriate time to reflect on the tremendous benefits that outreach programs provide. Early examples of outreach involved books, public lectures, and chemical demonstrations. In 1800 Count Rumford collaborated with influential Londoners to establish the Royal Institution as a means of providing lectures on science and technology to help working people to improve their lot. Humphry Davy, Michael Faraday, and many others continued the tradition. Faraday's own interest in science was sparked in part by Jane Marcet's book Conversations in Chemistry, whose friendly style made its contents accessible and fascinating to the young, highly intelligent bookbinder's apprentice. In the United States, Benjamin Silliman, first professor of chemistry at Yale, became widely known for his textbooks on geology and chemistry and for his ability as a popular lecturer. Silliman's lecture tours took him as far from New Haven as St. Louis and New Orleans. By the mid-1800s societies for the advancement of science and of chemistry were being set up in Europe. In 1876 American chemists who gathered at Priestley's grave in Northumberland, Pennsylvania, to commemorate the centennial of the discovery of oxygen saw the need for a permanent organization and founded the American Chemical Society. By the beginning of the 20th century these societies were supporting education and public awareness of science

  3. Optimization of PAM-4 transmitters based on lumped silicon photonic MZMs for high-speed short-reach optical links.

    Science.gov (United States)

    Zhou, Shiyu; Wu, Hsin-Ta; Sadeghipour, Khosrov; Scarcella, Carmelo; Eason, Cormac; Rensing, Marc; Power, Mark J; Antony, Cleitus; O'Brien, Peter; Townsend, Paul D; Ossieur, Peter

    2017-02-20

    We demonstrate how to optimize the performance of PAM-4 transmitters based on lumped Silicon Photonic Mach-Zehnder Modulators (MZMs) for short-reach optical links. Firstly, we analyze the trade-off that occurs between extinction ratio and modulation loss when driving an MZM with a voltage swing less than the MZM's Vπ. This is important when driver circuits are realized in deep submicron CMOS process nodes. Next, a driving scheme based upon a switched capacitor approach is proposed to maximize the achievable bandwidth of the combined lumped MZM and CMOS driver chip. This scheme allows the use of lumped MZM for high speed optical links with reduced RF driver power consumption compared to the conventional approach of driving MZMs (with transmission line based electrodes) with a power amplifier. This is critical for upcoming short-reach link standards such as 400Gb/s 802.3 Ethernet. The driver chip was fabricated using a 65nm CMOS technology and flip-chipped on top of the Silicon Photonic chip (fabricated using IMEC's ISIPP25G technology) that contains the MZM. Open eyes with 4dB extinction ratio for a 36Gb/s (18Gbaud) PAM-4 signal are experimentally demonstrated. The electronic driver chip has a core area of only 0.11mm2 and consumes 236mW from 1.2V and 2.4V supply voltages. This corresponds to an energy efficiency of 6.55pJ/bit including Gray encoder and retiming, or 5.37pJ/bit for the driver circuit only.

  4. Reaching teen farm workers with health and safety information: an evaluation of a high school ESL curriculum.

    Science.gov (United States)

    Teran, S; Strochlic, R; Bush, D; Baker, R; Meyers, J

    2008-04-01

    While childhood agricultural injury has long been recognized as an important public health issue, most research has focused on family farms and there have not been many interventions targeting hired youth. This study evaluated the impact of a high school English as a Second Language (ESL) curriculum, designed to provide teen agricultural workers with the knowledge and tools to protect their health and safety in the fields. Using a quasi-experimental design, the research consisted of two intervention groups and a comparison group, and included over 2,000 students from communities that lead California in agricultural production. The research findings revealed that the curriculum had significant impact in terms of increases in knowledge and attitudes, and nearly half of those interviewed after a summer of working in the fields reported implementing new behaviors to protect their health and safety. The curriculum also had extended effects in the broader community, as the majority of students reported sharing the new information with others. The study found that a school-based ESL curriculum is an effective intervention to reach and educate teen farm workers and that ESL classes can serve as a much-needed access point for young farm workers.

  5. Torix group Rickettsia are widespread in Culicoides biting midges (Diptera: Ceratopogonidae), reach high frequency and carry unique genomic features.

    Science.gov (United States)

    Pilgrim, Jack; Ander, Mats; Garros, Claire; Baylis, Matthew; Hurst, Gregory D D; Siozios, Stefanos

    2017-10-01

    There is increasing interest in the heritable bacteria of invertebrate vectors of disease as they present novel targets for control initiatives. Previous studies on biting midges (Culicoides spp.), known to transmit several RNA viruses of veterinary importance, have revealed infections with the endosymbiotic bacteria, Wolbachia and Cardinium. However, rickettsial symbionts in these vectors are underexplored. Here, we present the genome of a previously uncharacterized Rickettsia endosymbiont from Culicoides newsteadi (RiCNE). This genome presents unique features potentially associated with host invasion and adaptation, including genes for the complete non-oxidative phase of the pentose phosphate pathway, and others predicted to mediate lipopolysaccharides and cell wall modification. Screening of 414 Culicoides individuals from 29 Palearctic or Afrotropical species revealed that Rickettsia represent a widespread but previously overlooked association, reaching high frequencies in midge populations and present in 38% of the species tested. Sequence typing clusters the Rickettsia within the Torix group of the genus, a group known to infect several aquatic and hematophagous taxa. FISH analysis indicated the presence of Rickettsia bacteria in ovary tissue, indicating their maternal inheritance. Given the importance of biting midges as vectors, a key area of future research is to establish the impact of this endosymbiont on vector competence. © 2017 The Authors. Environmental Microbiology published by Society for Applied Microbiology and John Wiley & Sons Ltd.

  6. Reaching the hard-to-reach.

    Science.gov (United States)

    Valdes, C

    1992-01-01

    Guatemala's family planning (FP) programs are innovative but contraceptive use is only 23%. Total fertility is 5.3 children/woman, and the 9.5 million population will double in 23 years. The problem is poverty and illiteracy among rural residents removed from health services. 80% live in poverty and 80% are illiterate. Government effort is devoted to combating diseases such as diarrhea so there are few funds for implementing a comprehensive population policy. There is support within the national government but FP lacks priority status. APROFAM's goals are to use innovative marketing methods to inform the rural population who lack access to and knowledge about FP. Service delivery is constrained by the difficulty in reaching remote areas where 4 out of 10 indigenous Guatemalans live. Infant mortality can reach as high as 200/1000 live births. Population growth has slowed, and APROFAM plans to reach 16,000 more in the future. Promotions are conducted in several languages and aired on radio, television, and in the print media. It has been found that market research is the most effective strategy in reaching indigenous families. APROFAM has also been effective in upgrading service facilities through training, client surveys, and setting improved clinic standards. Breastfeeding, training, and voluntary sterilization programs contribute to the primary care effort. The example is given of Paulina Lebron from a very poor area who has learned how to space her children and thus improve the standard of living for her family. Eventually, she convinced herself and her family that sterilization was necessary, and now the couple enjoy the bliss of newlyweds without fear of pregnancy.

  7. Low resolution scans can provide a sufficiently accurate, cost- and time-effective alternative to high resolution scans for 3D shape analyses

    Directory of Open Access Journals (Sweden)

    Ariel E. Marcy

    2018-06-01

    Full Text Available Background Advances in 3D shape capture technology have made powerful shape analyses, such as geometric morphometrics, more feasible. While the highly accurate micro-computed tomography (µCT scanners have been the “gold standard,” recent improvements in 3D surface scanners may make this technology a faster, portable, and cost-effective alternative. Several studies have already compared the two devices but all use relatively large specimens such as human crania. Here we perform shape analyses on Australia’s smallest rodent to test whether a 3D scanner produces similar results to a µCT scanner. Methods We captured 19 delicate mouse (Pseudomys delicatulus crania with a µCT scanner and a 3D scanner for geometric morphometrics. We ran multiple Procrustes ANOVAs to test how variation due to scan device compared to other sources such as biologically relevant variation and operator error. We quantified operator error as levels of variation and repeatability. Further, we tested if the two devices performed differently at classifying individuals based on sexual dimorphism. Finally, we inspected scatterplots of principal component analysis (PCA scores for non-random patterns. Results In all Procrustes ANOVAs, regardless of factors included, differences between individuals contributed the most to total variation. The PCA plots reflect this in how the individuals are dispersed. Including only the symmetric component of shape increased the biological signal relative to variation due to device and due to error. 3D scans showed a higher level of operator error as evidenced by a greater spread of their replicates on the PCA, a higher level of multivariate variation, and a lower repeatability score. However, the 3D scan and µCT scan datasets performed identically in classifying individuals based on intra-specific patterns of sexual dimorphism. Discussion Compared to µCT scans, we find that even low resolution 3D scans of very small specimens are

  8. High-speed highly temperature stable 980 nm VCSELs operating at 25 Gb/s at up to 85 °C for short reach optical interconnects

    Science.gov (United States)

    Mutig, Alex; Lott, James A.; Blokhin, Sergey A.; Moser, Philip; Wolf, Philip; Hofmann, Werner; Nadtochiy, Alexey M.; Bimberg, Dieter

    2011-03-01

    The progressive penetration of optical communication links into traditional copper interconnect markets greatly expands the applications of vertical cavity surface emitting lasers (VCSELs) for the next-generation of board-to-board, moduleto- module, chip-to-chip, and on-chip optical interconnects. Stability of the VCSEL parameters at high temperatures is indispensable for such applications, since these lasers typically reside directly on or near integrated circuit chips. Here we present 980 nm oxide-confined VCSELs operating error-free at bit rates up to 25 Gbit/s at temperatures as high as 85 °C without adjustment of the drive current and peak-to-peak modulation voltage. The driver design is therefore simplified and the power consumption of the driver electronics is lowered, reducing the production and operational costs. Small and large signal modulation experiments at various temperatures from 20 up to 85 °C for lasers with different oxide aperture diameters are presented in order to analyze the physical processes controlling the performance of the VCSELs. Temperature insensitive maximum -3 dB bandwidths of around 13-15 GHz for VCSELs with aperture diameters of 10 μm and corresponding parasitic cut-off frequencies exceeding 22 GHz are observed. Presented results demonstrate the suitability of our VCSELs for practical high speed and high temperature stable short-reach optical links.

  9. Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis.

    Science.gov (United States)

    Mancardi, David A; Jönsson, Friederike; Iannascoli, Bruno; Khun, Huot; Van Rooijen, Nico; Huerre, Michel; Daëron, Marc; Bruhns, Pierre

    2011-02-15

    K/BxN serum-induced passive arthritis was reported to depend on the activation of mast cells, triggered by the activating IgG receptor FcγRIIIA, when engaged by IgG1 autoantibodies present in K/BxN serum. This view is challenged by the fact that FcγRIIIA-deficient mice still develop K/BxN arthritis and because FcγRIIIA is the only activating IgG receptor expressed by mast cells. We investigated the contribution of IgG receptors, IgG subclasses, and cells in K/BxN arthritis. We found that the activating IgG2 receptor FcγRIV, expressed only by monocytes/macrophages and neutrophils, was sufficient to induce disease. K/BxN arthritis occurred not only in mast cell-deficient W(sh) mice, but also in mice whose mast cells express no activating IgG receptors. We propose that at least two autoantibody isotypes, IgG1 and IgG2, and two activating IgG receptors, FcγRIIIA and FcγRIV, contribute to K/BxN arthritis, which requires at least two cell types other than mast cells, monocytes/macrophages, and neutrophils.

  10. Successful Reach and Adoption of a workplace health promotion RCT targeting a group of high-risk workers

    DEFF Research Database (Denmark)

    Jørgensen, Marie B; Rasmussen, Charlotte D N; Ekner, Dorte

    2010-01-01

    BACKGROUND: Cleaners are rarely introduced to workplace health promotion programs. The study's objective was to evaluate the reach and adoption of a workplace randomized controlled trial (RCT) among cleaners in Denmark. METHODS: Cleaning businesses with at least 30 employees, that could offer...... a weekly 1-hour intervention during working hours, were invited to participate. Employees working at least 20 hours/week were invited to answer a screening questionnaire and consent to participate. Analyses determined the differences in health variables between responders and non-responders, consenters...... employees, 78% responded to the screening questionnaire and 49% consented to participate. Consenters and participants differed from non-consenters and non-participants by having higher BMI, more chronic diseases and poorer musculoskeletal health. CONCLUSIONS: This study indicates that workplace health...

  11. Reach of the high-energy LHC for gluinos and top squarks in SUSY models with light Higgsinos

    Science.gov (United States)

    Baer, Howard; Barger, Vernon; Gainer, James S.; Serce, Hasan; Tata, Xerxes

    2017-12-01

    We examine the top squark (stop) and gluino reach of the proposed 33 TeV energy upgrade of the Large Hadron Collider (LHC33) in the Minimal Supersymmetric Standard Model (MSSM) with light Higgsinos and relatively heavy electroweak gauginos. In our analysis, we assume that stops decay to Higgsinos via t˜1→t Z˜1, t˜1→t Z˜2, and t˜1→b W˜1 with branching fractions in the ratio 1 ∶1 ∶2 (expected if the decay occurs dominantly via the superpotential Yukawa coupling), while gluinos decay via g ˜→t t˜1 or via three-body decays to third-generation quarks plus Higgsinos. These decay patterns are motivated by models of natural supersymmetry where Higgsinos are expected to be close in mass to mZ, but gluinos may be as heavy as 5-6 TeV, and stops may have masses up to ˜3 TeV . We devise cuts to optimize the signals from stop and gluino pair production at LHC33. We find that experiments at LHC33 should be able to discover stops with >5 σ significance if mt˜1<2.3 (2.8) [3.2] TeV for an integrated luminosity of 0.3 (1) [3 ] ab-1 . The corresponding reach for gluinos extends to 5 (5.5) [6] TeV. These results imply that experiments at LHC33 should be able to discover at least one of the stop or gluino pair signals even with an integrated luminosity of 0.3 ab-1 for natural supersymmetry models with no worse than 3% electroweak fine-tuning and quite likely both gluinos and stops for an integrated luminosity of 3 ab-1 .

  12. Sufficiency Grounded as Sufficiently Free: A Reply to Shlomi Segall

    DEFF Research Database (Denmark)

    Nielsen, Lasse

    2016-01-01

    be grounded on (i) any personal value, nor (ii) any impersonal value. Consequently, sufficientarianism is groundless. This article contains a rejoinder to this critique. Its main claim is that the value of autonomy holds strong potential for grounding sufficiency. It argues, firstly, that autonomy carries...... both personal value for its recipient as well as impersonal value, and that both of these values are suitable for grounding sufficiency. It thus follows that we should reject both (i) and (ii). Secondly, although autonomy is presumably the strongest candidate for grounding sufficiency, the article...... provides some counterargument to Segall’s rejection of the other candidates—the impersonal value of virtue; the personal value for the allocator; and the personal value for others. If the arguments are sound, they show that we need not worry about sufficientarianism being groundless....

  13. DYNAMIC SUFFICIENCY OF THE MAGNETICALLY SUSPENDED TRAIN

    Directory of Open Access Journals (Sweden)

    V. A. Polyakov

    2013-11-01

    Full Text Available Purpose. The basic criterion of the magnetically suspended train's consumer estimation is a quality of its mechanical motion. This motion is realized in unpredictable conditions and, for purposefulness preservation, should adapt to them. Such adaptation is possible only within the limits of system’s dynamic sufficiency. Sufficiency is understood as presence at system of resources, which allow one to realize its demanded motions without violating actual restrictions. Therefore presence of such resources is a necessary condition of preservation of required purposefulness of train's dynamics, and verification of the mentioned sufficiency is the major component of this dynamic research. Methodology. Methods of the set theory are used in work. Desirable and actual approachability spaces of the train are found. The train is considered dynamically sufficient in zones of the specified spaces overlapping. Findings. Within the limits of the accepted treatment of train's dynamic sufficiency, verification of its presence, as well as a stock (or deficiency of preservations can be executed by the search and the subsequent estimation of such overlapping zones. Operatively (directly during motion it can be realized on the train's ODC with use, for example, of computer mathematics system Mathematica. It possesses extensive opportunities of highly efficient and, at the same time, demanding an expense concerning small resources information manipulation. The efficiency of using of created technique is illustrated on an example of vehicle's acceleration research. Calculation is executed with use of the constructed computer model of interaction of an independent traction electromagnetic subsystem of an artifact with its mechanical subsystem. Originality. The technique of verification of the high-speed magnetically suspended train's dynamic sufficiency is developed. The technique is highly efficient, it provides sufficient presentation and demands an expense of the

  14. Energy Strategic Planning & Sufficiency Project

    Energy Technology Data Exchange (ETDEWEB)

    Retziaff, Greg

    2005-03-30

    This report provides information regarding options available, their advantages and disadvantages, and the costs for pursuing activities to advance Smith River Rancheria toward an energy program that reduces their energy costs, allows greater self-sufficiency and stimulates economic development and employment opportunities within and around the reservation. The primary subjects addressed in this report are as follows: (1) Baseline Assessment of Current Energy Costs--An evaluation of the historical energy costs for Smith River was conducted to identify the costs for each component of their energy supply to better assess changes that can be considered for energy cost reductions. (2) Research Viable Energy Options--This includes a general description of many power generation technologies and identification of their relative costs, advantages and disadvantages. Through this research the generation technology options that are most suited for this application were identified. (3) Project Development Considerations--The basic steps and associated challenges of developing a generation project utilizing the selected technologies are identified and discussed. This included items like selling to third parties, wheeling, electrical interconnections, fuel supply, permitting, standby power, and transmission studies. (4) Energy Conservation--The myriad of federal, state and utility programs offered for low-income weatherization and utility bill payment assistance are identified, their qualification requirements discussed, and the subsequent benefits outlined. (5) Establishing an Energy Organization--The report includes a high level discussion of formation of a utility to serve the Tribal membership. The value or advantages of such action is discussed along with some of the challenges. (6) Training--Training opportunities available to the Tribal membership are identified.

  15. High diversity of nitrogen-fixing bacteria in the upper reaches of the Heihe River, northwestern China

    Directory of Open Access Journals (Sweden)

    X. S. Tai

    2013-08-01

    Full Text Available Vegetation plays a key role in water conservation in the southern Qilian Mountains (northwestern China, located in the upper reaches of the Heihe River. Nitrogen-fixing bacteria are crucial for the protection of the nitrogen supply for vegetation in the region. In the present study, nifH gene clone libraries were established to determine differences between the nitrogen-fixing bacterial communities of the Potentilla parvifolia shrubland and the Carex alrofusca meadow in the southern Qilian Mountains. All of the identified nitrogen-fixing bacterial clones belonged to the Proteobacteria. At the genus level, Azospirillum was only detected in the shrubland soil, while Thiocapsa, Derxia, Ectothiorhodospira, Mesorhizobium, Klebsiella, Ensifer, Methylocella and Pseudomonas were only detected in the meadow soil. The phylogenetic tree was divided into five lineages: lineages I, II and III mainly contained nifH sequences obtained from the meadow soils, while lineage IV was mainly composed of nifH sequences obtained from the shrubland soils. The Shannon–Wiener index of the nifH genes ranged from 1.5 to 2.8 and was higher in the meadow soils than in the shrubland soils. Based on these analyses of diversity and phylogeny, the plant species were hypothesised to influence N cycling by enhancing the fitness of certain nitrogen-fixing taxa. The number of nifH gene copies and colony-forming units (CFUs of the cultured nitrogen-fixing bacteria were lower in the meadow soils than in the shrubland soils, ranging from 0.4 × 107 to 6.9 × 107 copies g−1 soil and 0.97 × 106 to 12.78 × 106 g−1 soil, respectively. Redundancy analysis (RDA revealed that the diversity and number of the nifH gene copies were primarily correlated with aboveground biomass in the shrubland soil. In the meadow soil, nifH gene diversity was most affected by altitude, while copy number was most impacted by soil-available K. These results suggest that the nitrogen-fixing bacterial

  16. High diversity of nitrogen-fixing bacteria in the upper reaches of the Heihe River, northwestern China

    Science.gov (United States)

    Tai, X. S.; Mao, W. L.; Liu, G. X.; Chen, T.; Zhang, W.; Wu, X. K.; Long, H. Z.; Zhang, B. G.; Zhang, Y.

    2013-08-01

    Vegetation plays a key role in water conservation in the southern Qilian Mountains (northwestern China), located in the upper reaches of the Heihe River. Nitrogen-fixing bacteria are crucial for the protection of the nitrogen supply for vegetation in the region. In the present study, nifH gene clone libraries were established to determine differences between the nitrogen-fixing bacterial communities of the Potentilla parvifolia shrubland and the Carex alrofusca meadow in the southern Qilian Mountains. All of the identified nitrogen-fixing bacterial clones belonged to the Proteobacteria. At the genus level, Azospirillum was only detected in the shrubland soil, while Thiocapsa, Derxia, Ectothiorhodospira, Mesorhizobium, Klebsiella, Ensifer, Methylocella and Pseudomonas were only detected in the meadow soil. The phylogenetic tree was divided into five lineages: lineages I, II and III mainly contained nifH sequences obtained from the meadow soils, while lineage IV was mainly composed of nifH sequences obtained from the shrubland soils. The Shannon-Wiener index of the nifH genes ranged from 1.5 to 2.8 and was higher in the meadow soils than in the shrubland soils. Based on these analyses of diversity and phylogeny, the plant species were hypothesised to influence N cycling by enhancing the fitness of certain nitrogen-fixing taxa. The number of nifH gene copies and colony-forming units (CFUs) of the cultured nitrogen-fixing bacteria were lower in the meadow soils than in the shrubland soils, ranging from 0.4 × 107 to 6.9 × 107 copies g-1 soil and 0.97 × 106 to 12.78 × 106 g-1 soil, respectively. Redundancy analysis (RDA) revealed that the diversity and number of the nifH gene copies were primarily correlated with aboveground biomass in the shrubland soil. In the meadow soil, nifH gene diversity was most affected by altitude, while copy number was most impacted by soil-available K. These results suggest that the nitrogen-fixing bacterial communities beneath Potentilla

  17. Is high dose methotrexate without irradiation of the brain sufficiently effective in prevention of CNS disease in children with acute lymphoblastic leukemia?

    International Nuclear Information System (INIS)

    Cap, J.; Foltinova, A.; Kaiserova, E.; Mojzesova, A.; Sejnova, D.; Jamarik, M.

    1998-01-01

    We present 5-year results of treatment in 93 children suffering from acute lymphoblastic leukemia using two therapeutic protocols containing multidrug chemotherapy including high dose methotrexate. We could ascertain different results in standard and high risk patients. In a group of 62 children with standard risk we observed improvement in complete remission rate being 98.9% after induction phase of therapy, only one patient died on septicemia. Relapse rate in this group was 21.2% and that 14. 7% in the bone marrow and 6.5% in CNS and no testicular relapse at all. In the group of 31 children with high risk leukemia all patients achieved complete remission. Only one of them died on acute pancreatitis due to toxicity. Overall relapse rate in this group was 28.9% with 12.8% of medullary relapse and 16.1 % of CNS relapse. The last one was significantly higher than in the previous study when brain irradiation was a part of therapeutic procedure. It seems that this treatment is effective mainly in the standard risk leukemia, however, in the high risk leukemias this procedure appears to be less effective in preventing CNS leukemia. In this group of patients irradiation of the brain need to be enclosed in the therapy. (authors)

  18. Sample-size dependence of diversity indices and the determination of sufficient sample size in a high-diversity deep-sea environment

    OpenAIRE

    Soetaert, K.; Heip, C.H.R.

    1990-01-01

    Diversity indices, although designed for comparative purposes, often cannot be used as such, due to their sample-size dependence. It is argued here that this dependence is more pronounced in high diversity than in low diversity assemblages and that indices more sensitive to rarer species require larger sample sizes to estimate diversity with reasonable precision than indices which put more weight on commoner species. This was tested for Hill's diversity number N sub(0) to N sub( proportional ...

  19. "I Think I'm Reaching My Potential": Students' Self-Determination Experiences in an Inclusive High School

    Science.gov (United States)

    Eisenman, Laura T.; Pell, Megan M.; Poudel, Bishwa B.; Pleet-Odle, Amy M.

    2015-01-01

    Through a 5-year qualitative case study of an inclusive high school, we examined students' experiences of self-determination. We conducted analyses of multiple interviews with students, parents, teachers, guidance staff, and administrators using grounded theory methods and guided by self-determination conceptual frameworks. Explicit expectations…

  20. High construal level can help negotiators to reach integrative agreements: The role of information exchange and judgement accuracy.

    Science.gov (United States)

    Wening, Stefanie; Keith, Nina; Abele, Andrea E

    2016-06-01

    In negotiations, a focus on interests (why negotiators want something) is key to integrative agreements. Yet, many negotiators spontaneously focus on positions (what they want), with suboptimal outcomes. Our research applies construal-level theory to negotiations and proposes that a high construal level instigates a focus on interests during negotiations which, in turn, positively affects outcomes. In particular, we tested the notion that the effect of construal level on outcomes was mediated by information exchange and judgement accuracy. Finally, we expected the mere mode of presentation of task material to affect construal levels and manipulated construal levels using concrete versus abstract negotiation tasks. In two experiments, participants negotiated in dyads in either a high- or low-construal-level condition. In Study 1, high-construal-level dyads outperformed dyads in the low-construal-level condition; this main effect was mediated by information exchange. Study 2 replicated both the main and mediation effects using judgement accuracy as mediator and additionally yielded a positive effect of a high construal level on a second, more complex negotiation task. These results not only provide empirical evidence for the theoretically proposed link between construal levels and negotiation outcomes but also shed light on the processes underlying this effect. © 2015 The British Psychological Society.

  1. Information geometry and sufficient statistics

    Czech Academy of Sciences Publication Activity Database

    Ay, N.; Jost, J.; Le, Hong-Van; Schwachhöfer, L.

    2015-01-01

    Roč. 162, 1-2 (2015), s. 327-364 ISSN 0178-8051 Institutional support: RVO:67985840 Keywords : Fisher quadratic form * Amari-Chentsov tensor * sufficient statistic Subject RIV: BA - General Mathematics Impact factor: 2.204, year: 2015 http://link.springer.com/article/10.1007/s00440-014-0574-8

  2. Four to seven random casual urine specimens are sufficient to estimate 24-h urinary sodium/potassium ratio in individuals with high blood pressure.

    Science.gov (United States)

    Iwahori, T; Ueshima, H; Torii, S; Saito, Y; Fujiyoshi, A; Ohkubo, T; Miura, K

    2016-05-01

    This study was done to clarify the optimal number and type of casual urine specimens required to estimate urinary sodium/potassium (Na/K) ratio in individuals with high blood pressure. A total of 74 individuals with high blood pressure, 43 treated and 31 untreated, were recruited from the Japanese general population. Urinary sodium, potassium and Na/K ratio were measured in both casual urine samples and 7-day 24-h urine samples and then analyzed by correlation and Bland-Altman analyses. Mean Na/K ratio from random casual urine samples on four or more days strongly correlated with the Na/K ratio of 7-day 24-h urine (r=0.80-0.87), which was similar to the correlation between 1 and 2-day 24-h urine and 7-day 24-h urine (r=0.75-0.89). The agreement quality for Na/K ratio of seven random casual urine for estimating the Na/K ratio of 7-day 24-h urine was good (bias: -0.26, limits of agreements: -1.53-1.01), and it was similar to that of 2-day 24-h urine for estimating 7-day 24-h values (bias: 0.07, limits of agreement: -1.03 to 1.18). Stratified analyses comparing individuals using antihypertensive medication and individuals not using antihypertensive medication showed similar results. Correlations of the means of casual urine sodium or potassium concentrations with 7-day 24-h sodium or potassium excretions were relatively weaker than those for Na/K ratio. The mean Na/K ratio of 4-7 random casual urine specimens on different days provides a good substitute for 1-2-day 24-h urinary Na/K ratio for individuals with high blood pressure.

  3. The High Cost of Child Care Puts Quality Care out of Reach for Many Families. Issue Brief.

    Science.gov (United States)

    Schulman, Karen

    This issue brief presents data on the cost of child care, collected from local child care resource and referral agencies (CCR&Rs) surveyed by the Children's Defense Fund. The report's key findings on the high cost of child care are: (1) child care for a 4-year-old in a child care center averages $4,000 to $6,000 a year in cities and states…

  4. Mild chemical pretreatments are sufficient for complete saccharification of steam-exploded residues and high ethanol production in desirable wheat accessions.

    Science.gov (United States)

    Zahoor; Tu, Yuanyuan; Wang, Lingqiang; Xia, Tao; Sun, Dan; Zhou, Shiguang; Wang, Yanting; Li, Ying; Zhang, Heping; Zhang, Tong; Madadi, Meysam; Peng, Liangcai

    2017-11-01

    In this study, a combined pretreatment was performed in four wheat accessions using steam explosion followed with different concentrations of H 2 SO 4 or NaOH, leading to increased hexoses yields by 3-6 folds from enzymatic hydrolysis. Further co-supplied with 1% Tween-80, Talq90 and Talq16 accessions exhibited an almost complete enzymatic saccharification of steam-exploded (SE) residues after 0.5% H 2 SO 4 or 1% NaOH pretreatment, with the highest bioethanol yields at 18.5%-19.4%, compared with previous reports about wheat bioethanol yields at 11%-17% obtained under relatively strong pretreatment conditions. Furthermore, chemical analysis indicated that much enhanced saccharification in Talq90 and Talq16 may be partially due to their relatively low cellulose CrI and DP values and high hemicellulose Ara and H-monomer levels in raw materials and SE residues. Hence, this study has not only demonstrated a mild pretreatment technology for a complete saccharification, but it has also obtained the high ethanol production in desirable wheat accessions. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Inorganic/organic nanocomposites: Reaching a high filler content without increasing viscosity using core-shell structured nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Benhadjala, W., E-mail: warda.benhadjala@cea.fr [IMS Laboratory - UMR CNRS 5218, University of Bordeaux, 351 Cours de la Libération, 33405 Talence (France); CEA, LETI, Minatec Campus, 38000 Grenoble (France); Gravoueille, M.; Weiss, M. [EDF, Centre d' Expertise et d' Inspection dans les Domaines de la Réalisation et de l' Exploitation (CEIDRE), Chinon, BP 80, 37420 Avoine (France); Bord-Majek, I.; Béchou, L.; Ousten, Y. [IMS Laboratory - UMR CNRS 5218, University of Bordeaux, 351 Cours de la Libération, 33405 Talence (France); Suhir, E. [Maseeh College of Engineering and Computer Science, Portland State University, Oregon 97201 (United States); Buet, M.; Louarn, M.; Rougé, F.; Gaud, V. [Polyrise SAS, 16 Avenue Pey Berland, 33607 Pessac (France)

    2015-11-23

    Extensive research is being conducted on the development of inorganic/organic nanocomposites for a wide variety of applications in microelectronics, biotechnologies, photonics, adhesives, or optical coatings. High filler contents are usually required to fully optimize the nanocomposites properties. However, numerous studies demonstrated that traditional composite viscosity increases with increasing the filler concentration reducing therefore significantly the material processability. In this work, we synthesized inorganic/organic core-shell nanocomposites with different shell thicknesses. By reducing the shell thickness while maintaining a constant core size, the nanoparticle molecular mass decreases but the nanocomposite filler fraction is correlatively increased. We performed viscosity measurements, which clearly highlighted that intrinsic viscosity of hybrid nanoparticles decreases as the molecular mass decreases, and thus, as the filler fraction increases, as opposed to Einstein predictions about the viscosity of traditional inorganic/polymer two-phase mixtures. This exceptional behavior, modeled by Mark-Houwink-Sakurada equation, proves to be a significant breakthrough for the development of industrializable nanocomposites with high filler contents.

  6. Keeping Teachers Up-to-date is essential to reach and maintain a High Quality University Education

    Directory of Open Access Journals (Sweden)

    Leonor Aguilar-Santelises

    2014-12-01

    Full Text Available A multidisciplinary group of teachers and scientists from the Faculty for Higher Education (FES Zaragoza from the National Autonomous University of Mexico (UNAM has been working during several years, forwarding and testing strategies for the continuous improvement of biochemistry theoretical and experimental teaching, within the various levels from the chemistry, pharmacy and biology (QFB curricula at our University. To provide our teachers with modern teaching abilities to satisfy current national demands of high-level education is our top priority. Therefore, we offer various activities to promote their continuous scientific and didactic updating. We also encourage self-awareness on the strong need for continuous adaptation and utilization of information and communication technologies (ICT that have become very popular among young generations. Teaching is not an isolated discipline. On the contrary, teaching is intimately related with social and economical circumstances. Teachers and students must be aware of their social environment, studying and applying modern techniques, improving their scientific capabilities, which are all necessary to approach national problems with an accurate utilization of national resources. Research and development have to be linked to the best teaching techniques that stimulate teachers and scientists to grow as educators and experimenters continuously looking for feedback from their students and colleagues. Our scientific meetings and advanced and basic courses on scientific topics and teaching techniques have contributed not only to promote individual teaching and scientific capabilities but also to update the study plans from the QFB curricula at our University.

  7. Mechanical properties of steel fiber reinforced reactive powder concrete following exposure to high temperature reaching 800 deg. C

    Energy Technology Data Exchange (ETDEWEB)

    Tai, Yuh-Shiou, E-mail: ystai@cc.cma.edu.tw [Department of Civil Engineering, ROC Military Academy, Kaohsiung, Taiwan (China); Pan, Huang-Hsing; Kung, Ying-Nien [Department of Civil Engineering, Kaohsiung University of Applied Sciences, Kaohsiung, Taiwan (China)

    2011-07-15

    Highlights: > The stress-strain relation of reactive powder concrete after exposure to high temperatures are tested by using displacement control. > Develops regression formulae to estimate the mechanical properties of RPC. > Valuable experimental data have been obtained about RPC with various fiber contents. These data include compressive strength, peak strain and modulus of elasticity. - Abstract: This study investigates the stress-strain relation of RPC in quasi-static loading after an elevated temperature. The cylinder specimens of RPC with {phi} 50 mm x 100 mm are examined at the room temperature and after 200-800 deg. C. Experimental results indicate that the residual compressive strength of RPC after heating from 200-300 deg. C increases more than that at room temperature, but, significantly decreases when the temperature exceeds 300 deg. C. The residual peak strains of RPC also initially increase up to 400-500 deg. C, then decrease gradually beyond 500 deg. C. Meanwhile, Young's modulus diminishes with an increasing temperature. Based on the regression analysis results, this study also develops regression formulae to estimate the mechanical properties of RPC after an elevated temperature, thus providing a valuable reference for industrial applications and design.

  8. Reach Address Database (RAD)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Reach Address Database (RAD) stores the reach address of each Water Program feature that has been linked to the underlying surface water features (streams,...

  9. Joint Inflammation and Early Degeneration Induced by High-Force Reaching Are Attenuated by Ibuprofen in an Animal Model of Work-Related Musculoskeletal Disorder

    Directory of Open Access Journals (Sweden)

    Jeffrey B. Driban

    2011-01-01

    Full Text Available We used our voluntary rat model of reaching and grasping to study the effect of performing a high-repetition and high-force (HRHF task for 12 weeks on wrist joints. We also studied the effectiveness of ibuprofen, administered in the last 8 weeks, in attenuating HRHF-induced changes in these joints. With HRHF task performance, ED1+ and COX2+ cells were present in subchondral radius, carpal bones and synovium; IL-1alpha and TNF-alpha increased in distal radius/ulna/carpal bones; chondrocytes stained with Terminal deoxynucleotidyl Transferase- (TDT- mediated dUTP-biotin nick end-labeling (TUNEL increased in wrist articular cartilages; superficial structural changes (e.g., pannus and reduced proteoglycan staining were observed in wrist articular cartilages. These changes were not present in normal controls or ibuprofen treated rats, although IL-1alpha was increased in reach limbs of trained controls. HRHF-induced increases in serum C1,2C (a biomarker of collagen I and II degradation, and the ratio of collagen degradation to synthesis (C1,2C/CPII; the latter a biomarker of collage type II synthesis were also attenuated by ibuprofen. Thus, ibuprofen treatment was effective in attenuating HRHF-induced inflammation and early articular cartilage degeneration.

  10. Energy Self-Sufficient Island

    International Nuclear Information System (INIS)

    Bratic, S.; Krajacic, G.; Duic, N.; Cotar, A.; Jardas, D.

    2011-01-01

    In order to analyze energy self-sufficient island, example of a smaller island, connected to the power system of a bigger island with an undersea cable, was taken. Mounting substation 10/0,4 is situated on the island and for the moment it provides enough electricity using the medium voltage line. It is assumed that the island is situated on the north part of the Adriatic Sea. The most important problem that occurs on the island is the population drop that occurs for a significant number of years, therefore, life standard needs to be improved, and economic development needs to be encouraged immediately. Local authorities to stimulate sustainable development on the island through different projects, to breath in a new life to the island, open new jobs and attract new people to come live there. Because of the planned development and increase of the population, energy projects, planned as a support to sustainable development, and later achievement of the energy self-sufficiency, is described in this paper. Therefore, Rewisland methodology appliance is described taking into the account three possible scenarios of energy development. Each scenario is calculated until year 2030. Also, what is taken into the account is 100% usage of renewable sources of energy in 2030. Scenario PTV, PP, EE - This scenario includes installation of solar photovoltaic modules and solar thermal collectors on the buildings roofs, as well as well as implementation of energy efficiency on the island (replacement of the street light bulbs with LED lightning, replacement of the old windows and doors on the houses, as well as the installation of the thermal insulation). Scenario PV island - This scenario, similarly to the previous one, includes installation of solar photovoltaic modules and solar thermal collectors an the residential buildings, as well as the 2 MW photovoltaic power plant and ''Green Hotel'', a building that satisfies all of its energy needs completely from renewable energy sources

  11. The State of the Science of Employment and Economic Self-Sufficiency for People with Intellectual and Developmental Disabilities

    Science.gov (United States)

    Nord, Derek; Luecking, Richard; Mank, David; Kiernan, William; Wray, Christina

    2013-01-01

    Employment, career advancement, and financial independence are highly valued in the United States. As expectations, they are often instilled at a young age and incentivized throughout adulthood. Despite their importance, employment and economic sufficiency continue to be out of reach for most people with intellectual and developmental disabilities…

  12. Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: A self-sufficient P450 with high expression and diverse substrate scope.

    Science.gov (United States)

    Porter, Joanne L; Sabatini, Selina; Manning, Jack; Tavanti, Michele; Galman, James L; Turner, Nicholas J; Flitsch, Sabine L

    2018-06-01

    Cytochrome P450 monooxygenases are able to catalyse a range of synthetically challenging reactions ranging from hydroxylation and demethylation to sulfoxidation and epoxidation. As such they have great potential for biocatalytic applications but are underutilised due to often-poor expression, stability and solubility in recombinant bacterial hosts. The use of self-sufficient P450 s with fused haem and reductase domains has already contributed heavily to improving catalytic efficiency and simplifying an otherwise more complex multi-component system of P450 and redox partners. Herein, we present a new addition to the class VII family with the cloning, sequencing and characterisation of the self-sufficient CYP116B62 Hal1 from Halomonas sp. NCIMB 172, the genome of which has not yet been sequenced. Hal1 exhibits high levels of expression in a recombinant E. coli host and can be utilised from cell lysate or used in purified form. Hal1 favours NADPH as electron donor and displays a diverse range of activities including hydroxylation, demethylation and sulfoxidation. These properties make Hal1 suitable for future biocatalytic applications or as a template for optimisation through engineering. Copyright © 2018 Elsevier Inc. All rights reserved.

  13. Sufficiency of the Nuclear Fuel

    International Nuclear Information System (INIS)

    Pevec, D.; Knapp, V.; Matijevic, M.

    2008-01-01

    Estimation of the nuclear fuel sufficiency is required for rational decision making on long-term energy strategy. In the past an argument often invoked against nuclear energy was that uranium resources are inadequate. At present, when climate change associated with CO 2 emission is a major concern, one novel strong argument for nuclear energy is that it can produce large amounts of energy without the CO 2 emission. Increased interest in nuclear energy is evident, and a new look into uranium resources is relevant. We examined three different scenarios of nuclear capacity growth. The low growth of 0.4 percent per year in nuclear capacity is assumed for the first scenario. The moderate growth of 1.5 percent per year in nuclear capacity preserving the present share in total energy production is assumed for the second scenario. We estimated draining out time periods for conventional resources of uranium using once through fuel cycle for the both scenarios. For the first and the second scenario we obtained the draining out time periods for conventional uranium resources of 154 years and 96 years, respectively. These results are, as expected, in agreement with usual evaluations. However, if nuclear energy is to make a major impact on CO 2 emission it should contribute much more in the total energy production than at present level of 6 percent. We therefore defined the third scenario which would increase nuclear share in the total energy production from 6 percent in year 2020 to 30 percent by year 2060 while the total world energy production would grow by 1.5 percent per year. We also looked into the uranium requirement for this scenario, determining the time window for introduction of uranium or thorium reprocessing and for better use of uranium than what is the case in the once through fuel cycle. The once through cycle would be in this scenario sustainable up to about year 2060 providing most of the expected but undiscovered conventional uranium resources were turned

  14. Teratology testing under REACH.

    Science.gov (United States)

    Barton, Steve

    2013-01-01

    REACH guidelines may require teratology testing for new and existing chemicals. This chapter discusses procedures to assess the need for teratology testing and the conduct and interpretation of teratology tests where required.

  15. Global reach and engagement

    Science.gov (United States)

    2016-09-01

    Popular culture reflects both the interests of and the issues affecting the general public. As concerns regarding climate change and its impacts grow, is it permeating into popular culture and reaching that global audience?

  16. Bacterial diversity and composition during rain events with and without Saharan dust influence reaching a high mountain lake in the Alps.

    Science.gov (United States)

    Peter, Hannes; Hörtnagl, Paul; Reche, Isabel; Sommaruga, Ruben

    2014-12-01

    The diversity of airborne microorganisms that potentially reach aquatic ecosystems during rain events is poorly explored. Here, we used a culture-independent approach to characterize bacterial assemblages during rain events with and without Saharan dust influence arriving to a high mountain lake in the Austrian Alps. Bacterial assemblage composition differed significantly between samples with and without Saharan dust influence. Although alpha diversity indices were within the same range in both sample categories, rain events with Atlantic or continental origins were dominated by Betaproteobacteria, whereas those with Saharan dust intrusions were dominated by Gammaproteobacteria. The high diversity and evenness observed in all samples suggests that different sources of bacteria contributed to the airborne assemblage collected at the lake shore. During experiments with bacterial assemblages collected during rain events with Saharan dust influence, cell numbers rapidly increased in sterile lake water from initially ∼3 × 103 cell ml-1 to 3.6-11.1 x105 cells ml-1 within 4-5 days, and initially, rare taxa dominated at the end of the experiment. Our study documents the dispersal of viable bacteria associated to Saharan dust intrusions travelling northwards as far as 47° latitude.

  17. Therapeutic whole-body hypothermia reduces mortality in severe traumatic brain injury if the cooling index is sufficiently high: meta-analyses of the effect of single cooling parameters and their integrated measure.

    Science.gov (United States)

    Olah, Emoke; Poto, Laszlo; Hegyi, Peter; Szabo, Imre; Hartmann, Petra; Solymar, Margit; Petervari, Erika; Balasko, Marta; Habon, Tamas; Rumbus, Zoltan; Tenk, Judit; Rostas, Ildiko; Weinberg, Jordan; Romanovsky, Andrej A; Garami, Andras

    2018-04-21

    Therapeutic hypothermia was investigated repeatedly as a tool to improve the outcome of severe traumatic brain injury (TBI), but previous clinical trials and meta-analyses found contradictory results. We aimed to determine the effectiveness of therapeutic whole-body hypothermia on the mortality of adult patients with severe TBI by using a novel approach of meta-analysis. We searched the PubMed, EMBASE, and Cochrane Library databases from inception to February 2017. The identified human studies were evaluated regarding statistical, clinical, and methodological designs to ensure inter-study homogeneity. We extracted data on TBI severity, body temperature, mortality, and cooling parameters; then we calculated the cooling index, an integrated measure of therapeutic hypothermia. Forest plot of all identified studies showed no difference in the outcome of TBI between cooled and not cooled patients, but inter-study heterogeneity was high. On the contrary, by meta-analysis of RCTs which were homogenous with regards to statistical, clinical designs and precisely reported the cooling protocol, we showed decreased odds ratio for mortality in therapeutic hypothermia compared to no cooling. As independent factors, milder and longer cooling, and rewarming at < 0.25°C/h were associated with better outcome. Therapeutic hypothermia was beneficial only if the cooling index (measure of combination of cooling parameters) was sufficiently high. We conclude that high methodological and statistical inter-study heterogeneity could underlie the contradictory results obtained in previous studies. By analyzing methodologically homogenous studies, we show that cooling improves the outcome of severe TBI and this beneficial effect depends on certain cooling parameters and on their integrated measure, the cooling index.

  18. Compliance with birth dose of Hepatitis B vaccine in high endemic and hard to reach areas in the Colombian amazon: results from a vaccination survey.

    Science.gov (United States)

    Choconta-Piraquive, Luz Angela; De la Hoz-Restrepo, Fernando; Sarmiento-Limas, Carlos Arturo

    2016-07-21

    Hepatitis B vaccination was introduced into the Expanded Program of Immunization in Colombia in 1992, in response to WHO recommendations on hepatitis B immunization. Colombia is a low endemic country for Hepatitis B virus infection (HBV) but it has several high endemic areas like the Amazon basin where more than 70 % of adults had been infected. A cross- sectional study was carried out in three rural areas of the Colombian Amazon to evaluate compliance with the recommended schedule for hepatitis B vaccine in Colombian children (one monovalent dose given in the first 24 h after birth + 3 doses of a pentavalent containing Hepatitis B. (DPT + Hib + Hep B). A household survey was conducted in order to collect vaccination data from children aged from 6 months to studied, 79 % received a monovalent dose of hepatitis B vaccine, but only 30.7 % were vaccinated in the first 24 h after birth. This proportion did not increase by age or subsequent birth cohorts. Coverage with three doses of a DTP-Hib-HepB vaccine was 98 %, but most children did not receive them according to the recommended schedule. Being born in a health facility was the strongest predictor of receiving a timely birth dose. This study suggests that more focused strategies on improving compliance with hepatitis B birth dose should be implemented in rural areas of the Amazon, if elimination of perinatal transmission of HBV is to be achieved. Increasing the proportion of newborns delivered at health facilities should be one of the priorities to reach that goal.

  19. Reaching the unreached.

    Science.gov (United States)

    Ariyaratne, A T

    1989-01-01

    Embodied in the child survival revolution are ideological, methodological, and organizational innovations aimed at radical change in the condition of the world's children as rapidly as possible. In countries such as Sri Lanka, child survival and health for all by the year 2000 often seem to be impossible goals, given the tumultuous socioeconomic and political conditions. In Sri Lanka, the quality of life has been eroded, not enhanced, by the importation of Western technology and managerial capitalism and the destruction of indigenous processes. The chaos and violence that have been brought into the country have made it difficult to reach the poor children, women, and refugees in rural areas with primary health care interventions. Sri Lanka's unreachable--the decision making elites--have blocked access to the unreached--the urban and rural poor. If governments are to reach the unreached, they must remove the obstacles to a people-centered, community development process. It is the people themselves, and the institutions of their creation, that can reach the children amidst them in greatest need. To achieve this task, local communities must be provided with basic human rights, the power to make decisions that affect their lives, necessary resources, and appropriate technologies. Nongovernmental organizations can play a crucial role as bridges between the unreached and the unreachable by promoting community empowerment, aiding in the formation of networks of community organizations, and establishing linkages with government programs. If the ruling elites in developing countries can be persuaded to accommodate the needs and aspirations of those who, to date, have been excluded from the development process, the child survival revolution can be a nonviolent one.

  20. Solar Hydrogen Reaching Maturity

    Directory of Open Access Journals (Sweden)

    Rongé Jan

    2015-09-01

    Full Text Available Increasingly vast research efforts are devoted to the development of materials and processes for solar hydrogen production by light-driven dissociation of water into oxygen and hydrogen. Storage of solar energy in chemical bonds resolves the issues associated with the intermittent nature of sunlight, by decoupling energy generation and consumption. This paper investigates recent advances and prospects in solar hydrogen processes that are reaching market readiness. Future energy scenarios involving solar hydrogen are proposed and a case is made for systems producing hydrogen from water vapor present in air, supported by advanced modeling.

  1. BROOKHAVEN: Proton goal reached

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    On March 30 the 35-year old Alternating Gradient Synchrotron (AGS) exceeded its updated design goal of 6 x 10 13 protons per pulse (ppp), by accelerating 6.3 x 10 13 ppp, a world record intensity. This goal was set 11 years ago and achieving it called for the construction of a new booster and the reconstruction of much of the AGS. The booster was completed in 1991, and reached its design intensity of 1.5 x 10 13 ppp in 1993. The AGS reconstruction was finished in 1994, and by July of that year the AGS claimed a new US record intensity for a proton synchrotron of 4 x 10 13 ppp, using four booster pulses. Reaching the design intensity was scheduled for 1995. In 1994, the AGS had seemed to be solidly limited to 4 x 10 13 ppp, but in 1995 the operations crew, working on their own in the quiet of the owl shift, steadily improved the intensity, regularly setting new records, much to the bemusement of the machine physicists. The physicists, however, did contribute. A second harmonic radiofrequency cavity in the booster increased the radiofrequency bucket area for capture, raising the booster intensity from 1.7 to 2.1 x 10 13 ppp. In the AGS, new radiofrequency power supplies raised the available voltage from 8 to 13 kV, greatly enhancing the beam loading capabilities of the system. A powerful new transverse damping system successfully controlled instabilities that otherwise would have destroyed the beam in less than a millisecond. Also in the AGS, 35th harmonic octupole resonances were found

  2. BROOKHAVEN: Proton goal reached

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1995-09-15

    On March 30 the 35-year old Alternating Gradient Synchrotron (AGS) exceeded its updated design goal of 6 x 10{sup 13} protons per pulse (ppp), by accelerating 6.3 x 10{sup 13} ppp, a world record intensity. This goal was set 11 years ago and achieving it called for the construction of a new booster and the reconstruction of much of the AGS. The booster was completed in 1991, and reached its design intensity of 1.5 x 10{sup 13} ppp in 1993. The AGS reconstruction was finished in 1994, and by July of that year the AGS claimed a new US record intensity for a proton synchrotron of 4 x 10{sup 13} ppp, using four booster pulses. Reaching the design intensity was scheduled for 1995. In 1994, the AGS had seemed to be solidly limited to 4 x 10{sup 13} ppp, but in 1995 the operations crew, working on their own in the quiet of the owl shift, steadily improved the intensity, regularly setting new records, much to the bemusement of the machine physicists. The physicists, however, did contribute. A second harmonic radiofrequency cavity in the booster increased the radiofrequency bucket area for capture, raising the booster intensity from 1.7 to 2.1 x 10{sup 13} ppp. In the AGS, new radiofrequency power supplies raised the available voltage from 8 to 13 kV, greatly enhancing the beam loading capabilities of the system. A powerful new transverse damping system successfully controlled instabilities that otherwise would have destroyed the beam in less than a millisecond. Also in the AGS, 35th harmonic octupole resonances were found.

  3. Reaching Beyond The Stars

    Science.gov (United States)

    Baker, Mariah; Rosenthal, L.; Gaughan, A.; Hopkins, E.

    2014-01-01

    Strawbridge Observatory at Haverford College is home to a undergraduate-led public observing program. Our program holds ~once monthly public events throughout the academic year that take advantage of eyepiece observing on our 16-inch and 12-inch telescopes as well as of the classroom, library, and projection system. These resources allow us to organize a variety of astronomy related activities that are engaging for individuals of all ages: accessible student talks, current film screenings and even arts and crafts for the families who attend with young children. These events aim to spark curiosity in others about scientific discovery and about the remarkable nature of the world in which we live. In addition to exciting local families about astronomy, this program has excited Haverford students from a range of disciplines about both science and education. Being entirely student led means that we are able to take the initiative in planning, coordinating and running all events, fostering an atmosphere of collaboration, experimentation and commitment amongst our volunteers. Additionally, this program is one of the few at Haverford that regularly reaches beyond the campus walls to promote and build relationships with the outside community. In light of this, our program presents a distinctive and enlightening opportunity for student volunteers: we get to use our scientific backgrounds to educate a general audience, while also learning from them about how to communicate and inspire in others the excitement we feel about the subject of astronomy. The work on this project has been supported by NSF AST-1151462.

  4. GAP-REACH

    Science.gov (United States)

    Lewis-Fernández, Roberto; Raggio, Greer A.; Gorritz, Magdaliz; Duan, Naihua; Marcus, Sue; Cabassa, Leopoldo J.; Humensky, Jennifer; Becker, Anne E.; Alarcón, Renato D.; Oquendo, María A.; Hansen, Helena; Like, Robert C.; Weiss, Mitchell; Desai, Prakash N.; Jacobsen, Frederick M.; Foulks, Edward F.; Primm, Annelle; Lu, Francis; Kopelowicz, Alex; Hinton, Ladson; Hinton, Devon E.

    2015-01-01

    Growing awareness of health and health care disparities highlights the importance of including information about race, ethnicity, and culture (REC) in health research. Reporting of REC factors in research publications, however, is notoriously imprecise and unsystematic. This article describes the development of a checklist to assess the comprehensiveness and the applicability of REC factor reporting in psychiatric research publications. The 16-itemGAP-REACH© checklist was developed through a rigorous process of expert consensus, empirical content analysis in a sample of publications (N = 1205), and interrater reliability (IRR) assessment (N = 30). The items assess each section in the conventional structure of a health research article. Data from the assessment may be considered on an item-by-item basis or as a total score ranging from 0% to 100%. The final checklist has excellent IRR (κ = 0.91). The GAP-REACH may be used by multiple research stakeholders to assess the scope of REC reporting in a research article. PMID:24080673

  5. UX-15 Reaches LEP

    CERN Multimedia

    2001-01-01

    The creation of the world's largest sandstone cavern, not a small feat! At the bottom, cave-in preventing steel mesh can be seen clinging to the top of the tunnel. The digging of UX-15, the cavern that will house ATLAS, reached the upper ceiling of LEP on October 10th. The breakthrough which took place nearly 100 metres underground occurred precisely on schedule and exactly as planned. But much caution was taken beforehand to make the LEP breakthrough clean and safe. To prevent the possibility of cave-ins in the side tunnels that will eventually be attached to the completed UX-15 cavern, reinforcing steel mesh was fixed into the walls with bolts. Obviously no people were allowed in the LEP tunnels below UX-15 as the breakthrough occurred. The area was completely evacuated and fences were put into place to keep all personnel out. However, while personnel were being kept out of the tunnels below, this has been anything but the case for the work taking place up above. With the creation of the world's largest...

  6. [Vitamin-antioxidant sufficiency of winter sports athletes].

    Science.gov (United States)

    Beketova, N A; Kosheleva, O V; Pereverzeva, O G; Vrzhesinskaia, O A; Kodentsova, V M; Solntseva, T N; Khanfer'ian, R A

    2013-01-01

    The sufficiency of 169 athletes (six disciplines: bullet shooting, biathlon, bobsleigh, skeleton, freestyle skiing, snowboarding) with vitamins A, E, C, B2, and beta-carotene has been investigated in April-September 2013. All athletes (102 juniors, mean age--18.5 +/- 0.3 years, and 67 adult high-performance athletes, mean age--26.8 +/- 0.7 years) were sufficiently supplied with vitamin A (70.7 +/- 1.7 mcg/dl). Mean blood serum retinol level was 15% higher the upper limit of the norm (80 mcg/dl) in biathletes while median reached 90.9 mcg/dl. Blood serum level of tocopherols (1.22 +/- 0.03 mg/dl), ascorbic acid (1.06 +/- 0.03 mg/dl), riboflavin (7.1 +/- 0.4 ng/ml), and beta-carotene (25.1 +/- 1.7 mcg/dl) was in within normal range, but the incidence of insufficiency of vitamins E, C, B2, and carotenoid among athletes varied in the range of 0-25, 0-17, 15-67 and 42-75%, respectively. 95% of adults and 80% of younger athletes were sufficiently provided with vitamin E. Vitamin E level in blood serum of juniors involved in skeleton and biathlon was lower by 51 and 72% (p antioxidants (beta-carotene and vitamins E and C). In other sports, the relative quantity of athletes sufficiently supplied with these essential nutrients did not exceed 56%. The quota of supplied with all antioxidants among bullet shooters (31.1%) and bobsledders (23.5%) was significantly (p antioxidant (mainly beta-carotene) was most often recorded among persons engaged in bullet shooting (67%). The simultaneous lack of all three antioxidants was found only in freestylers and bobsledders (about 5%). Decreased level of antioxidants in blood serum in 40% of athletes was combined with vitamin B2 deficiency. The data obtained suggest the necessity to optimize diet vitamin content of all athletes, taking into account the age and gender differences. Contrary to prevailing stereotypes the optimization must involve not only an increase in the consumption of vitamins (vitamins E, B group) and carotenoids, but

  7. Energy Strategic Planning & Self-Sufficiency Project

    Energy Technology Data Exchange (ETDEWEB)

    Greg Retzlaff

    2005-03-30

    This report provides information regarding options available, their advantages and disadvantages, and the costs for pursuing activities to advance Smith River Rancheria toward an energy program that reduces their energy costs, allows greater self-sufficiency and stimulates economic development and employment opportunities within and around the reservation. The primary subjects addressed in this report are as follow: (1) Baseline Assessment of Current Energy Costs--An evaluation of the historical energy costs for Smith River was conducted to identify the costs for each component of their energy supply to better assess changes that can be considered for energy cost reductions. (2) Research Viable Energy Options--This includes a general description of many power generation technologies and identification of their relative costs, advantages and disadvantages. Through this research the generation technology options that are most suited for this application were identified. (3) Project Development Considerations--The basic steps and associated challenges of developing a generation project utilizing the selected technologies are identified and discussed. This included items like selling to third parties, wheeling, electrical interconnections, fuel supply, permitting, standby power, and transmission studies. (4) Energy Conservation--The myriad of federal, state and utility programs offered for low-income weatherization and utility bill payment assistance are identified, their qualification requirements discussed, and the subsequent benefits outlined. (5) Establishing an Energy Organization--The report includes a high level discussion of formation of a utility to serve the Tribal membership. The value or advantages of such action is discussed along with some of the challenges. (6) Training--Training opportunities available to the Tribal membership are identified.

  8. Reaching the teachers

    CERN Multimedia

    2001-01-01

    The fourth edition of CERN's High School Teachers programme welcomed 38 teachers to the Laboratory this July. For three weeks the teachers were immersed in the life of CERN, giving them a unique experience to take back to their classrooms.   Participants and organisers of the HST 2001 programme. The pupils of the teachers who attended the High School Teachers (HST) programme at CERN will notice a difference when they meet their teachers at the beginning of next term. They'll see a new-found enthusiasm in their eyes, and this will be thanks to the three weeks they spent at the Laboratory attending the summer students' lectures and working with other teachers from around the world. 'This experience fires you up again!,' explains Wim Peeters, a Belgian teacher at CERN for the second time. For many teachers of physics, university is a long time ago. Physics research has moved on, and there are many new things to learn. That's why CERN has the HST, so that teachers can mix with university students in ...

  9. Mexican agencies reach teenagers.

    Science.gov (United States)

    Brito Lemus, R; Beamish, J

    1992-08-01

    The Gente Joven project of the Mexican Foundation for Family Planning (MEXFAM) trains young volunteers in 19 cities to spread messages about sexually transmitted diseases and population growth to their peers. They also distribute condoms and spermicides. It also uses films and materials to spread its messages. The project would like to influence young men's behavior, but the Latin image of machismo poses a big challenge. It would like to become more responsible toward pregnancy prevention. About 50% of adolescents have sexual intercourse, but few use contraceptives resulting in a high adolescent pregnancy rate. Many of these pregnant teenagers choose not to marry. Adolescent pregnancy leads to girls leaving school, few marketable skills, and rearing children alone. Besides women who began childbearing as a teenager have 1.5 times more children than other women. Male involvement in pregnancy prevention should improve these statistics. As late as 1973, the Health Code banned promotion and sales of contraceptives, but by 1992 about 50% of women of reproductive age use contraceptives. The Center for the Orientation of Adolescents has organized 8 Young Men's Clubs in Mexico City to involve male teenagers more in family planning and to develop self-confidence. It uses a holistic approach to their development through discussions with their peers. A MEXFAM study shows that young men are not close with their fathers who tend to exude a machismo attitude, thus the young men do not have a role model for responsible sexual behavior. MEXFAM's work is cut out for them, however, since the same study indicates that 50% of the young men believe it is fine to have 1 girlfriend and 33% think women should earn more than men. A teenager volunteer reports, however, that more boys have been coming to him for contraception and information than girls in 1992 while in other years girls outnumbered the boys.

  10. Demonstration of the trauma nurses talk tough seat belt diversion program in North Carolina reaches high-risk drivers : traffic tech.

    Science.gov (United States)

    2014-03-01

    Nationally, more than 8 of every 10 drivers wear seat belts, but : individual State belt rates vary from as high as 98% to as low as : 69%. Within individual States, rural areas often have lower rates. : Strong seat belt laws and highly visible enfor...

  11. Reaching mothers and babies with early postnatal home visits: the implementation realities of achieving high coverage in large-scale programs.

    Directory of Open Access Journals (Sweden)

    Deborah Sitrin

    Full Text Available BACKGROUND: Nearly half of births in low-income countries occur without a skilled attendant, and even fewer mothers and babies have postnatal contact with providers who can deliver preventive or curative services that save lives. Community-based maternal and newborn care programs with postnatal home visits have been tested in Bangladesh, Malawi, and Nepal. This paper examines coverage and content of home visits in pilot areas and factors associated with receipt of postnatal visits. METHODS: Using data from cross-sectional surveys of women with live births (Bangladesh 398, Malawi: 900, Nepal: 615, generalized linear models were used to assess the strength of association between three factors - receipt of home visits during pregnancy, birth place, birth notification - and receipt of home visits within three days after birth. Meta-analytic techniques were used to generate pooled relative risks for each factor adjusting for other independent variables, maternal age, and education. FINDINGS: The proportion of mothers and newborns receiving home visits within three days after birth was 57% in Bangladesh, 11% in Malawi, and 50% in Nepal. Mothers and newborns were more likely to receive a postnatal home visit within three days if the mother received at least one home visit during pregnancy (OR2.18, CI1.46-3.25, the birth occurred outside a facility (OR1.48, CI1.28-1.73, and the mother reported a CHW was notified of the birth (OR2.66, CI1.40-5.08. Checking the cord was the most frequently reported action; most mothers reported at least one action for newborns. CONCLUSIONS: Reaching mothers and babies with home visits during pregnancy and within three days after birth is achievable using existing community health systems if workers are available; linked to communities; and receive training, supplies, and supervision. In all settings, programs must evaluate what community delivery systems can handle and how to best utilize them to improve postnatal care

  12. Self-sufficiency, free trade and safety.

    Science.gov (United States)

    Rautonen, Jukka

    2010-01-01

    The relationship between free trade, self-sufficiency and safety of blood and blood components has been a perennial discussion topic in the blood service community. Traditionally, national self-sufficiency has been perceived as the ultimate goal that would also maximize safety. However, very few countries are, or can be, truly self-sufficient when self-sufficiency is understood correctly to encompass the whole value chain from the blood donor to the finished product. This is most striking when plasma derived medicines are considered. Free trade of blood products, or competition, as such can have a negative or positive effect on blood safety. Further, free trade of equipment and reagents and several plasma medicines is actually necessary to meet the domestic demand for blood and blood derivatives in most countries. Opposing free trade due to dogmatic reasons is not in the best interest of any country and will be especially harmful for the developing world. Competition between blood services in the USA has been present for decades. The more than threefold differences in blood product prices between European blood services indicate that competition is long overdue in Europe, too. This competition should be welcomed but carefully and proactively regulated to avoid putting safe and secure blood supply at risk. Copyright 2009 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.

  13. Denmark. Self-sufficiency and reserves management

    International Nuclear Information System (INIS)

    Erceville, H. d'.

    1997-01-01

    Since 1991, Denmark is a self-sufficient and a net petroleum and natural gas exporting country. Like all neighboring countries of the North sea, this country enjoys many advantages. However, Denmark exports and imports about a third of its hydrocarbons. This policy is a way to control its reserves for the future. (J.S.)

  14. Exploring Societal Preferences for Energy Sufficiency Measures in Switzerland

    International Nuclear Information System (INIS)

    Moser, Corinne; Rösch, Andreas; Stauffacher, Michael

    2015-01-01

    Many countries are facing a challenging transition toward more sustainable energy systems, which produce more renewables and consume less energy. The latter goal can only be achieved through a combination of efficiency measures and changes in people’s lifestyles and routine behaviors (i.e., sufficiency). While research has shown that acceptance of technical efficiency is relatively high, there is a lack of research on societal preferences for sufficiency measures. However, this is an important prerequisite for designing successful interventions to change behavior. This paper analyses societal preferences for different energy-related behaviors in Switzerland. We use an online choice-based conjoint analysis (N = 150) to examine preferences for behaviors with high technical potentials for energy demand reduction in the following domains: mobility, heating, and food. Each domain comprises different attributes across three levels of sufficiency. Respondents were confronted with trade-off situations evoked through different fictional lifestyles that comprised different combinations of attribute levels. Through a series of trade-off decisions, participants were asked to choose their preferred lifestyle. The results revealed that a vegetarian diet was considered the most critical issue that respondents were unwilling to trade off, followed by distance to workplace and means of transportation. The highest willingness to trade off was found for adjustments in room temperature, holiday travel behaviors, and living space. Participants’ preferences for the most energy-sufficient lifestyles were rather low. However, the study showed that there were lifestyles with substantive energy-saving potentials that were well accepted among respondents. Our study results suggest that the success of energy-sufficiency interventions might depend strongly on the targeted behavior. We speculate that they may face strong resistance (e.g., vegetarian diet). Thus, it seems promising to

  15. Exploring Societal Preferences for Energy Sufficiency Measures in Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Moser, Corinne, E-mail: corinne.moser@zhaw.ch [Institute of Sustainable Development, School of Engineering, Zurich University of Applied Sciences, Winterthur (Switzerland); Natural and Social Science Interface, Institute for Environmental Decisions, Department of Environmental Systems Science, ETH Zürich, Zürich (Switzerland); Rösch, Andreas [Natural and Social Science Interface, Institute for Environmental Decisions, Department of Environmental Systems Science, ETH Zürich, Zürich (Switzerland); Stauffacher, Michael [Natural and Social Science Interface, Institute for Environmental Decisions, Department of Environmental Systems Science, ETH Zürich, Zürich (Switzerland); Transdisciplinarity Laboratory, Department of Environmental Systems Science, ETH Zürich, Zürich (Switzerland)

    2015-09-16

    Many countries are facing a challenging transition toward more sustainable energy systems, which produce more renewables and consume less energy. The latter goal can only be achieved through a combination of efficiency measures and changes in people’s lifestyles and routine behaviors (i.e., sufficiency). While research has shown that acceptance of technical efficiency is relatively high, there is a lack of research on societal preferences for sufficiency measures. However, this is an important prerequisite for designing successful interventions to change behavior. This paper analyses societal preferences for different energy-related behaviors in Switzerland. We use an online choice-based conjoint analysis (N = 150) to examine preferences for behaviors with high technical potentials for energy demand reduction in the following domains: mobility, heating, and food. Each domain comprises different attributes across three levels of sufficiency. Respondents were confronted with trade-off situations evoked through different fictional lifestyles that comprised different combinations of attribute levels. Through a series of trade-off decisions, participants were asked to choose their preferred lifestyle. The results revealed that a vegetarian diet was considered the most critical issue that respondents were unwilling to trade off, followed by distance to workplace and means of transportation. The highest willingness to trade off was found for adjustments in room temperature, holiday travel behaviors, and living space. Participants’ preferences for the most energy-sufficient lifestyles were rather low. However, the study showed that there were lifestyles with substantive energy-saving potentials that were well accepted among respondents. Our study results suggest that the success of energy-sufficiency interventions might depend strongly on the targeted behavior. We speculate that they may face strong resistance (e.g., vegetarian diet). Thus, it seems promising to

  16. Increasing urban water self-sufficiency: New era, new challenges

    DEFF Research Database (Denmark)

    Rygaard, Martin; Binning, Philip John; Albrechtsen, Hans-Jørgen

    2011-01-01

    and 15 in-depth case studies, solutions used to increase water self-sufficiency in urban areas are analyzed. The main drivers for increased self-sufficiency were identified to be direct and indirect lack of water, constrained infrastructure, high quality water demands and commercial and institutional...... pressures. Case studies demonstrate increases in self-sufficiency ratios to as much as 80% with contributions from recycled water, seawater desalination and rainwater collection. The introduction of alternative water resources raises several challenges: energy requirements vary by more than a factor of ten...... amongst the alternative techniques, wastewater reclamation can lead to the appearance of trace contaminants in drinking water, and changes to the drinking water system can meet tough resistance from the public. Public water-supply managers aim to achieve a high level of reliability and stability. We...

  17. POLITICAL ECONOMIC ANALYSIS OF RICE SELF-SUFFICIENCY IN INDONESIA

    Directory of Open Access Journals (Sweden)

    Sri Nuryanti

    2018-01-01

    Full Text Available Rice self-sufficiency is an important programme in Indonesia. The programme has four major targets, i.e. increasing production, stabilizing prices and reserve stocks, and minimizing import. For that purpose, the government gave a mandate to a parastatal, namely National Logistic Agency (Bulog in implementing the rice policies. Some studies found that involvement of such a parastatal could lead to government failure in budget allocation. The study aimed to estimate social cost of rice self-sufficiency programme based on the implementation of rice instrument policies by Bulog. The study used the national annual data of 2002–2014 period. The method used was the political preference function model to estimate economic rent and dead-weight loss using rice price elasticity of demand and supply. The result showed that in terms of percentage of food security budget, the average of economic rent reached IDR 6.37 trillion per annum (18.54%, while the average of dead-weight loss amounted at IDR 0.90 trillion per annum (2.34%. It proved that rice self-sufficiency programme along with the involvement of Bulog was economically inefficient. The government should provide better agricultural infrastructure, review governmental procurement prices, and stop rice import policy to remedy market failure.

  18. Error Bounds: Necessary and Sufficient Conditions

    Czech Academy of Sciences Publication Activity Database

    Outrata, Jiří; Kruger, A.Y.; Fabian, Marián; Henrion, R.

    2010-01-01

    Roč. 18, č. 2 (2010), s. 121-149 ISSN 1877-0533 R&D Projects: GA AV ČR IAA100750802 Institutional research plan: CEZ:AV0Z10750506; CEZ:AV0Z10190503 Keywords : Error bounds * Calmness * Subdifferential * Slope Subject RIV: BA - General Mathematics Impact factor: 0.333, year: 2010 http://library.utia.cas.cz/separaty/2010/MTR/outrata-error bounds necessary and sufficient conditions.pdf

  19. The Army Ethic-Inchoate but Sufficient

    Science.gov (United States)

    2015-06-12

    are constraints imposed by this thesis. Delimitations include the scope, jus ad bellum, cultural relativism , descriptive ethics , and implementation...politicians. Third, this thesis will not look in depth at cultural relativism and how changes in laws and society’s philosophical and ethical ...THE ARMY ETHIC –INCHOATE BUT SUFFICIENT A thesis presented to the Faculty of the U.S. Army Command and General Staff College

  20. Reduction of the hydraulic retention time at constant high organic loading rate to reach the microbial limits of anaerobic digestion in various reactor systems.

    Science.gov (United States)

    Ziganshin, Ayrat M; Schmidt, Thomas; Lv, Zuopeng; Liebetrau, Jan; Richnow, Hans Hermann; Kleinsteuber, Sabine; Nikolausz, Marcell

    2016-10-01

    The effects of hydraulic retention time (HRT) reduction at constant high organic loading rate on the activity of hydrogen-producing bacteria and methanogens were investigated in reactors digesting thin stillage. Stable isotope fingerprinting was additionally applied to assess methanogenic pathways. Based on hydA gene transcripts, Clostridiales was the most active hydrogen-producing order in continuous stirred tank reactor (CSTR), fixed-bed reactor (FBR) and anaerobic sequencing batch reactor (ASBR), but shorter HRT stimulated the activity of Spirochaetales. Further decreasing HRT diminished Spirochaetales activity in systems with biomass retention. Based on mcrA gene transcripts, Methanoculleus and Methanosarcina were the predominantly active in CSTR and ASBR, whereas Methanosaeta and Methanospirillum activity was more significant in stably performing FBR. Isotope values indicated the predominance of aceticlastic pathway in FBR. Interestingly, an increased activity of Methanosaeta was observed during shortening HRT in CSTR and ASBR despite high organic acids concentrations, what was supported by stable isotope data. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Metasurface holograms reaching 80% efficiency.

    Science.gov (United States)

    Zheng, Guoxing; Mühlenbernd, Holger; Kenney, Mitchell; Li, Guixin; Zentgraf, Thomas; Zhang, Shuang

    2015-04-01

    Surfaces covered by ultrathin plasmonic structures--so-called metasurfaces--have recently been shown to be capable of completely controlling the phase of light, representing a new paradigm for the design of innovative optical elements such as ultrathin flat lenses, directional couplers for surface plasmon polaritons and wave plate vortex beam generation. Among the various types of metasurfaces, geometric metasurfaces, which consist of an array of plasmonic nanorods with spatially varying orientations, have shown superior phase control due to the geometric nature of their phase profile. Metasurfaces have recently been used to make computer-generated holograms, but the hologram efficiency remained too low at visible wavelengths for practical purposes. Here, we report the design and realization of a geometric metasurface hologram reaching diffraction efficiencies of 80% at 825 nm and a broad bandwidth between 630 nm and 1,050 nm. The 16-level-phase computer-generated hologram demonstrated here combines the advantages of a geometric metasurface for the superior control of the phase profile and of reflectarrays for achieving high polarization conversion efficiency. Specifically, the design of the hologram integrates a ground metal plane with a geometric metasurface that enhances the conversion efficiency between the two circular polarization states, leading to high diffraction efficiency without complicating the fabrication process. Because of these advantages, our strategy could be viable for various practical holographic applications.

  2. Energy self-sufficiency in Northampton, Massachusetts

    Energy Technology Data Exchange (ETDEWEB)

    1979-10-01

    The study is not an engineering analysis but begins the process of exploring the potential for conservation and local renewable-resource development in a specific community, Northampton, Massachusetts, with the social, institutional, and environmental factors in that community taken into account. Section I is an extensive executive summary of the full study, and Section II is a detailed examination of the potential for increased local energy self-sufficiency in Northampton, including current and future demand estimates, the possible role of conservation and renewable resources, and a discussion of the economic and social implications of alternative energy systems. (MOW)

  3. Proposal of balloon and satellite observations of MeV gammas using Electron Tracking Compton Camera for reaching a high sensitivity of 1 mCrab

    Science.gov (United States)

    Takada, Atsushi; Tanimori, Toru

    2016-04-01

    ETCC with a gas Time Projection Chamber (TPC) and pixel GSO scintillators, by measuring electron tracks precisely, provides both a strong background rejection by dE/dx of the track and well-defined 2-dimensional Point Spread Function (PDF) with better than several degrees by adding the arc direction of incident gammas (SPD: Scatter Plane Deviation) with the ARM (angular Resolution Measure) direction measured in standard Compton Camera (CC). In 2006 its background rejection was revealed by SMILE-I balloon experiment with 10cm-cubic ETCC using the dE/dx of tracks. In 2013, 30cm-cube-ETCC has been developed to catch gammas from Crab in next SMILE-II balloon with >5sigma detection for 4 hrs. Now its sensitivity has been improved to 10sigma by attaining the angular resolution of the track (SPD angle) to that determined by multiple scattering of the gas. Thus, we show the ability of ETCC to give a better significance by a factor of 10 than that of standard CCs having same detection area by electron tracking?and we have found that SPD is an essential to define the PSF of Compton imaging quantitatively. Such a well-defined PSF is, for the first time, able to provide reliable sensitivity in Compton imaging without assuming the use of optimization algorithm. These studies uncover the uncertainties of CCs from both points of view of the intense background and the difficulty of the definition of the PSF, and overcome the above problems. Based on this technology, SMILE-II with 3atm CF4 gas is expected to provide a 5times better sensitivity than COMPTEL in one month balloon, and 4modules of 50cm-cube ETCCs would exceed over 10^-12 erg/cm^2s^1 (1mCrab) in satellite. Here we summarize the performance of the ETCC and new astrophysics opened in near future by high sensitive observation of MeV gamma-rays.

  4. Reaching High Interactive Levels with Situated Agents

    Directory of Open Access Journals (Sweden)

    Guzmán-Obando J.

    2013-01-01

    Full Text Available El documento presenta un proceso coordinado a través del cual los agentes situados son capaces de trabajar en forma conjunta con el conocimiento de sus habilidades para interactuar con otras entidades similares. Una buena coordinación se deriva de que cada agente situado es capaz de representar sus tasas de idoneidad para llevar a cabo cualquier acción de una manera eficaz. Además de utilizar dichas tasas, un agente puede coordinar sus acciones con otros agentes. En este sentido, cada agente situado trata de seleccionar y realizar sólo las acciones con los mayores índices de ejecución. Algunos experimentos en un verdadero fútbol robótico banco de pruebas están diseñadas para poner en práctica el enfoque coordinado propuesto. Observaciones finales concluir la eficacia y las ventajas de la obra presentada con el fin de aumentar el rendimiento de un equipo integrado por agentes situados cuando tienen que resolver tareas complejas en un escenario dinámico, competitivo e impredecible.

  5. Unemployment reaches eight year high / Ashley Brettell

    Index Scriptorium Estoniae

    Brettell, Ashley

    2009-01-01

    Statistikaameti andmetel tõusis töötuse määr Eestis viimase kaheksa aasta kõrgeima tasemeni ning jõudis aasta esimeses kvartalis 11,4 protsendini. Tööga hõivatute arv vähenes aastaga 44 000 võrra.

  6. Ideal energy self-sufficient bioclimatic house

    Energy Technology Data Exchange (ETDEWEB)

    Talamo, C.

    1990-04-01

    This paper points out some of the interesting architectural features of a conceptual house being designed to be self-sufficient relative to the use of conventional energy sources. Brief notes are given on the following special design characteristics: the house's orientation and form - essentially a V - shaped two storey design with an orientation such as to maximize the surface area exposed to winter insolation; its special low emissivity glazing equipped with nightfall insulating screens; the adoption of maximized insulation, in which case cost benefits were assessed based on amortization over the entire life span of the house; hybrid space heating and ventilation systems involving the integration of pumps and ventilators for air circulation, and the use of a varied mix of active and passive solar heating and cooling systems.

  7. Reaching ignition in the tokamak

    International Nuclear Information System (INIS)

    Furth, H.P.

    1985-06-01

    This review covers the following areas: (1) the physics of burning plasmas, (2) plasma physics requirements for reaching ignition, (3) design studies for ignition devices, and (4) prospects for an ignition project

  8. The state of the science of employment and economic self-sufficiency for people with intellectual and developmental disabilities.

    Science.gov (United States)

    Nord, Derek; Luecking, Richard; Mank, David; Kiernan, William; Wray, Christina

    2013-10-01

    Employment, career advancement, and financial independence are highly valued in the United States. As expectations, they are often instilled at a young age and incentivized throughout adulthood. Despite their importance, employment and economic sufficiency continue to be out of reach for most people with intellectual and developmental disabilities (IDD). Over the last quarter century, extensive research and effort has been committed to understanding and improving these phenomena. This paper summarizes this employment research base by reviewing the literature on the effectiveness of the current employment support system, employment-specific interventions, and the economics and cost benefits of employment for people with IDD. Recommendations and directions for future research are also presented.

  9. Restoring Maximum Vertical Browsing Reach in Sauropod Dinosaurs.

    Science.gov (United States)

    Paul, Gregory S

    2017-10-01

    The ongoing controversy centered on neck posture and function in sauropod dinosaurs is misplaced for a number of reasons. Because of an absence of pertinent data it is not possible to accurately restore the posture and range of motion in long necked fossil animals, only gross approximations are possible. The existence of a single "neutral posture" in animals with long, slender necks may not exist, and its relationship to feeding habits is weak. Restorations of neutral osteological neck posture based on seemingly detailed diagrams of cervical articulations are not reliable because the pictures are not sufficiently accurate due to a combination of illustration errors, and distortion of the fossil cervicals. This is all the more true because fossil cervical series lack the critical inter-centra cartilage. Maximum vertical reach is more readily restorable and biologically informative for long necked herbivores. Modest extension of 10° between each caudal cervical allowed high shouldered sauropods to raise the cranial portion of their necks to vertical postures that allowed them to reach floral resources far higher than seen in the tallest mammals. This hypothesis is supported by the dorsally extended articulation of the only known co-fused sauropod cervicals. Many sauropods appear to have been well adapted for rearing in order to boost vertical reach, some possessed retroverted pelves that may have allowed them to walk slowly while bipedal. A combination of improved high browsing abilities and sexual selection probably explains the unusually long necks of tall ungulates and super tall sauropods. Anat Rec, 2017. © 2017 Wiley Periodicals, Inc. Anat Rec, 300:1802-1825, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  10. Guess LOD approach: sufficient conditions for robustness.

    Science.gov (United States)

    Williamson, J A; Amos, C I

    1995-01-01

    Analysis of genetic linkage between a disease and a marker locus requires specifying a genetic model describing both the inheritance pattern and the gene frequencies of the marker and trait loci. Misspecification of the genetic model is likely for etiologically complex diseases. In previous work we have shown through analytic studies that misspecifying the genetic model for disease inheritance does not lead to excess false-positive evidence for genetic linkage provided the genetic marker alleles of all pedigree members are known, or can be inferred without bias from the data. Here, under various selection or ascertainment schemes we extend these previous results to situations in which the genetic model for the marker locus may be incorrect. We provide sufficient conditions for the asymptotic unbiased estimation of the recombination fraction under the null hypothesis of no linkage, and also conditions for the limiting distribution of the likelihood ratio test for no linkage to be chi-squared. Through simulation studies we document some situations under which asymptotic bias can result when the genetic model is misspecified. Among those situations under which an excess of false-positive evidence for genetic linkage can be generated, the most common is failure to provide accurate estimates of the marker allele frequencies. We show that in most cases false-positive evidence for genetic linkage is unlikely to result solely from the misspecification of the genetic model for disease or trait inheritance.

  11. When is there sufficient information from the Site Investigations?

    International Nuclear Information System (INIS)

    Andersson, Johan; Munier, Raymond; Stroem, Anders; Soederbaeck, Bjoern; Almen, Karl-Erik; Olsson, Lars

    2004-04-01

    SKB has started site investigations for a deep repository for spent nuclear fuel at two different sites in Sweden. The investigations should provide necessary information for a licence application aimed at starting underground exploration. The investigations and analyses of them are supposed to provide the broad knowledge base that is required to achieve the overall goals of the site investigation phase. The knowledge will be utilized to evaluate the suitability of investigated sites for the deep repository and must be comprehensive enough to: Show whether the selected site satisfies requirements on safety and technical aspects. Serve as a basis for adaptation of the deep repository to the characteristics of the site with an acceptable impact on society and the environment. Permit comparisons with other investigated sites. Furthermore, the investigations are discontinued when the reliability of the site description has reached such a level that the body of data for safety assessment and design is sufficient, or until the body of data shows that the rock does not satisfy the requirements. These objectives are valid, but do not provide sufficient and concrete guidance. For this reason SKB has conducted this project which should acquire concrete guidance on how to judge when the surface based Site Investigation Phase does not need to continue. After a general assessment of the problem, the following specific objectives of the current work were identified: Demonstrate concretely how the assessed uncertainties in a Site Description based on a specific level of investigations, together with expected feedback from Safety Assessment and Engineering, can be used to decide whether the site investigations are sufficient - or need to continue. This demonstration will be based on a practical application of relevant aspects of decision analysis tools. Highlight and make concrete the type of feedback to be expected from Safety Assessment and Engineering and show how this feedback

  12. Environmental stressors afflicting tailwater stream reaches across the United States

    Science.gov (United States)

    Miranda, Leandro E.; Krogman, R. M.

    2014-01-01

    The tailwater is the reach of a stream immediately below an impoundment that is hydrologically, physicochemically and biologically altered by the presence and operation of a dam. The overall goal of this study was to gain a nationwide awareness of the issues afflicting tailwater reaches in the United States. Specific objectives included the following: (i) estimate the percentage of reservoirs that support tailwater reaches with environmental conditions suitable for fish assemblages throughout the year, (ii) identify and quantify major sources of environmental stress in those tailwaters that do support fish assemblages and (iii) identify environmental features of tailwater reaches that determine prevalence of key fish taxa. Data were collected through an online survey of fishery managers. Relative to objective 1, 42% of the 1306 reservoirs included in this study had tailwater reaches with sufficient flow to support a fish assemblage throughout the year. The surface area of the reservoir and catchment most strongly delineated reservoirs maintaining tailwater reaches with or without sufficient flow to support a fish assemblage throughout the year. Relative to objective 2, major sources of environmental stress generally reflected flow variables, followed by water quality variables. Relative to objective 3, zoogeography was the primary factor discriminating fish taxa in tailwaters, followed by a wide range of flow and water quality variables. Results for objectives 1–3 varied greatly among nine geographic regions distributed throughout the continental United States. Our results provide a large-scale view of the effects of reservoirs on tailwater reaches and may help guide research and management needs.

  13. Deuterium-tritium fuel self-sufficiency in fusion reactors

    International Nuclear Information System (INIS)

    Abdou, M.A.; Vold, E.L.; Gung, C.Y.; Youssef, M.Z.; Shin, K.

    1986-01-01

    Conditions necessary to achieve deuterium-tritium fuel self-sufficiency in fusion reactors are derived through extensive modeling and calculations of the required and achievable tritium breeding ratios as functions of the many reactor parameters and candidate design concepts. It is found that the excess margin in the breeding potential is not sufficient to cover all present uncertainties. Thus, the goal of attaining fuel self-sufficiency significantly restricts the allowable parameter space and design concepts. For example, the required breeding ratio can be reduced by (A) attaining high tritium fractional burnup, >5%, in the plasma, (B) achieving very high reliability, >99%, and very short times, <1 day, to fix failures in the tritium processing system, and (C) ensuring that nonradioactive decay losses from all subsystems are extremely low, e.g., <0.1% for the plasma exhaust processing system. The uncertainties due to nuclear data and calculational methods are found to be significant, but they are substantially smaller than those due to uncertainties in system definition

  14. ALMA Telescope Reaches New Heights

    Science.gov (United States)

    2009-09-01

    ball at a distance of nine miles, and to keep their smooth reflecting surfaces accurate to less than the thickness of a human hair. Once the transporter reached the high plateau it carried the antenna to a concrete pad -- a docking station with connections for power and fiber optics -- and positioned it with an accuracy of a small fraction of an inch. The transporter is guided by a laser steering system and, just like some cars, also has ultrasonic collision detectors. These sensors ensure the safety of the state-of-the-art antennas as the transporter drives them across what will soon be a rather crowded plateau. Ultimately, ALMA will have at least 66 antennas distributed over about 200 pads, spread over distances of up to 11.5 miles and operating as a single, giant telescope. Even when ALMA is fully operational, the transporters will be used to move the antennas between pads to reconfigure the telescope for different kinds of observations. This first ALMA antenna at the high site will soon be joined by others, and the ALMA team looks forward to making their first observations from the Chajnantor plateau. They plan to link three antennas by early 2010, and to make the first scientific observations with ALMA in the second half of 2011. ALMA will help astronomers answer important questions about our cosmic origins. The telescope will observe the Universe using light with millimeter and submillimeter wavelengths, between infrared light and radio waves in the electromagnetic spectrum. Light at these wavelengths comes from some of the coldest, and from some of the most distant objects in the cosmos. These include cold clouds of gas and dust where new stars are being born, or remote galaxies towards the edge of the observable universe. The Universe is relatively unexplored at submillimeter wavelengths, as the telescopes need extremely dry atmospheric conditions, such as those at Chajnantor, and advanced detector technology. The Atacama Large Millimeter/submillimeter Array

  15. RECORDS REACHING RECORDING DATA TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    G. W. L. Gresik

    2013-07-01

    Full Text Available The goal of RECORDS (Reaching Recording Data Technologies is the digital capturing of buildings and cultural heritage objects in hard-to-reach areas and the combination of data. It is achieved by using a modified crane from film industry, which is able to carry different measuring systems. The low-vibration measurement should be guaranteed by a gyroscopic controlled advice that has been , developed for the project. The data were achieved by using digital photography, UV-fluorescence photography, infrared reflectography, infrared thermography and shearography. Also a terrestrial 3D laser scanner and a light stripe topography scanner have been used The combination of the recorded data should ensure a complementary analysis of monuments and buildings.

  16. Records Reaching Recording Data Technologies

    Science.gov (United States)

    Gresik, G. W. L.; Siebe, S.; Drewello, R.

    2013-07-01

    The goal of RECORDS (Reaching Recording Data Technologies) is the digital capturing of buildings and cultural heritage objects in hard-to-reach areas and the combination of data. It is achieved by using a modified crane from film industry, which is able to carry different measuring systems. The low-vibration measurement should be guaranteed by a gyroscopic controlled advice that has been , developed for the project. The data were achieved by using digital photography, UV-fluorescence photography, infrared reflectography, infrared thermography and shearography. Also a terrestrial 3D laser scanner and a light stripe topography scanner have been used The combination of the recorded data should ensure a complementary analysis of monuments and buildings.

  17. REACH and nanomaterials: current status

    International Nuclear Information System (INIS)

    Alessandrelli, Maria; Di Prospero Fanghella, Paola; Polci, Maria Letizia; Castelli, Stefano; Pettirossi, Flavio

    2015-01-01

    New challenges for regulators are emerging about a specific assessment and appropriate management of the potential risks of nanomaterials. In the framework of European legislation on chemicals, Regulation (EC) No. 1907/2006 REACH aims to ensure the safety of human health and the environment through the collection of information on the physico-chemical characteristics of the substances and on their profile (eco) toxicological and the identification of appropriate risk management linked to 'exposure to these substances without impeding scientific progress and the competitiveness of industry. In order to cover the current shortage of information on the safety of nanomaterials and tackle the acknowledged legal vacuum, are being a rich activities, carried out both by regulators both by stake holders, and discussions on the proposals for adapting the European regulatory framework for chemicals . The European Commission is geared to strengthen the REACH Regulation by means of updates of its annexes. The importance of responding to the regulatory requirements has highlighted the need for cooperation between European organizations, scientists and industries to promote and ensure the safe use of nanomaterials. [it

  18. Performance reach in the LHC for 2012

    International Nuclear Information System (INIS)

    Arduini, G.

    2012-01-01

    Based on the 2011 experience and Machine Development study results, the performance reach of the LHC with 25 and 50 ns beams will be addressed for operation at 3.5 and 4 TeV. The possible scrubbing scenarios and potential intensity limitations resulting from vacuum, heating will be taken into account wherever possible. The paper mainly covers the performance of the two high luminosity regions in IR1 and IR5. (author)

  19. Effects of Experimental High Flow Releases and Increased Fluctuations in Flow from Glen Canyon Dam on Abundance, Growth, and Survival Rates of Early Life Stages of Rainbow Trout in the Lee's Ferry Reach of the Colorado River

    Science.gov (United States)

    Korman, Josh

    2010-05-01

    The abundance of adult fish populations is controlled by the growth and survival rates of early life stages. Evaluating the effects of flow regimes on early life stages is therefore critical to determine how these regimes affect the abundance of adult populations. Experimental high flow releases from Glen Canyon Dam, primarily intended to conserve fine sediment and improve habitat conditions for native fish in the Colorado River in Grand Canyon, AZ, have been conducted in 1996, 2004, and 2008. These flows potentially affect the Lee's Ferry reach rainbow trout population, located immediately downstream of the dam, which supports a highly valued fishery and likely influences the abundance of rainbow trout in Grand Canyon. Due to concerns about negative effects of high trout abundance on endangered native fish, hourly variation in flow from Glen Canyon Dam was experimentally increased between 2003 and 2005 to reduce trout abundance. This study reports on the effects of experimental high flow releases and fluctuating flows on early life stages of rainbow trout in the Lee's Ferry reach based on monthly sampling of redds (egg nests) and the abundance and growth of age-0 trout between 2003 and 2009. Data on spawn timing, spawning elevations, and intergravel temperatures were integrated in a model to estimate the magnitude and seasonal trend in incubation mortality resulting from redd dewatering due to fluctuations in flow. Experimental fluctuations from January through March promoted spawning at higher elevations where the duration of dewatering was longer and intergravel temperatures exceeded lethal thresholds. Flow-dependent incubation mortality rates were 24% (2003) and 50% (2004) in years with higher flow fluctuations, compared to 5-11% under normal operations (2006-2009). Spatial and temporal predictions of mortality were consistent with direct observations of egg mortality determined from the excavation of 125 redds. The amount of variation in backcalculated hatch

  20. When is there sufficient information from the Site Investigations?

    Energy Technology Data Exchange (ETDEWEB)

    Andersson, Johan [JA Streamflow AB, Aelvsjoe (Sweden); Munier, Raymond; Stroem, Anders; Soederbaeck, Bjoern [Swedish Nuclear Fuel and Waste Management Co., Stockholm (Sweden); Almen, Karl-Erik [KEA Geo-konsult (Sweden); Olsson, Lars [Geostatistik AB, Tumba (Sweden)

    2004-04-01

    SKB has started site investigations for a deep repository for spent nuclear fuel at two different sites in Sweden. The investigations should provide necessary information for a licence application aimed at starting underground exploration. The investigations and analyses of them are supposed to provide the broad knowledge base that is required to achieve the overall goals of the site investigation phase. The knowledge will be utilized to evaluate the suitability of investigated sites for the deep repository and must be comprehensive enough to: Show whether the selected site satisfies requirements on safety and technical aspects. Serve as a basis for adaptation of the deep repository to the characteristics of the site with an acceptable impact on society and the environment. Permit comparisons with other investigated sites. Furthermore, the investigations are discontinued when the reliability of the site description has reached such a level that the body of data for safety assessment and design is sufficient, or until the body of data shows that the rock does not satisfy the requirements. These objectives are valid, but do not provide sufficient and concrete guidance. For this reason SKB has conducted this project which should acquire concrete guidance on how to judge when the surface based Site Investigation Phase does not need to continue. After a general assessment of the problem, the following specific objectives of the current work were identified: Demonstrate concretely how the assessed uncertainties in a Site Description based on a specific level of investigations, together with expected feedback from Safety Assessment and Engineering, can be used to decide whether the site investigations are sufficient - or need to continue. This demonstration will be based on a practical application of relevant aspects of decision analysis tools. Highlight and make concrete the type of feedback to be expected from Safety Assessment and Engineering and show how this feedback

  1. Effects of High-Flow Experiments from Glen Canyon Dam on Abundance, Growth, and Survival Rates of Early Life Stages of Rainbow Trout in the Lees Ferry Reach of the Colorado River

    Science.gov (United States)

    Korman, Josh; Kaplinski, Matthew; Melis, Theodore S.

    2010-01-01

    High-flow experiments (HFEs) from Glen Canyon Dam are primarily intended to conserve fine sediment and improve habitat conditions for native fish in the Colorado River as it flows through Grand Canyon National Park, Arizona. These experimental flows also have the potential to affect the rainbow trout (Oncorhynchus mykiss) population in the Lees Ferry tailwater reach immediately below the dam, which supports a highly valued recreational fishery and likely influences the abundance of rainbow trout in Grand Canyon. Understanding how flow regimes affect the survival and growth of juvenile rainbow trout is critical to interpreting trends in adult abundance. This study reports on the effects of HFEs in 2004 and 2008 on early life stages of rainbow trout in the Lees Ferry reach on the basis of monthly sampling of redds (egg nests) and the abundance of the age-0 trout (fertilization to about 1 to 2 months from emergence) and their growth during a 7-year period between 2003 and 2009. Multiple lines of evidence indicate that the March 2008 HFE resulted in a large increase in early survival rates of age-0 trout because of an improvement in habitat conditions. A stock-recruitment analysis demonstrated that age-0 abundance in July 2008 was more than fourfold higher than expected, given the number of viable eggs that produced these fish. A hatch-date analysis showed that early survival rates were much higher for cohorts that hatched about 1 month after the 2008 HFE (about April 15, 2008) relative to those fish that hatched before this date. These cohorts, fertilized after the 2008 HFE, would have emerged into a benthic invertebrate community that had recovered, and was possibly enhanced by, the HFE. Interannual differences in growth of age-0 trout, determined on the basis of otolith microstructure, support this hypothesis. Growth rates in the summer and fall of 2008 (0.44 mm/day) were virtually the same as in 2006 (0.46 mm/day), the highest recorded during 6 years, even though

  2. Improving exposure scenario definitions within REACH

    DEFF Research Database (Denmark)

    Lee, Jihyun; Pizzol, Massimo; Thomsen, Marianne

    In recent years, the paradigm of chemical management system has changed from being toxicity oriented and media based to being risk oriented and receptor based. This trend is evident not only regarding environmental quality standards, but also for industrial chemical regulations. Political...... instruments to support a precautionary chemicals management system and to protect receptor’s health have also been increasing. Since 2007, the European Union adopted REACH (the Regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals): REACH makes industry responsible for assessing...... and managing the risks posed by industrial chemicals and providing appropriate safety information to their users (EC, 2007). However, to ensure a high level of protection of human health and the environment, there is a need to consider ‘aggregate exposure’ including background exposures from environment which...

  3. Reaching for the red planet

    Science.gov (United States)

    David, L

    1996-05-01

    The distant shores of Mars were reached by numerous U.S. and Russian spacecraft throughout the 1960s to mid 1970s. Nearly 20 years have passed since those successful missions which orbited and landed on the Martian surface. Two Soviet probes headed for the planet in July, 1988, but later failed. In August 1993, the U.S. Mars Observer suddenly went silent just three days before it was to enter orbit around the planet and was never heard from again. In late 1996, there will be renewed activity on the launch pads with three probes departing for the red planet: 1) The U.S. Mars Global Surveyor will be launched in November on a Delta II rocket and will orbit the planet for global mapping purposes; 2) Russia's Mars '96 mission, scheduled to fly in November on a Proton launcher, consists of an orbiter, two small stations which will land on the Martian surface, and two penetrators that will plow into the terrain; and finally, 3) a U.S. Discovery-class spacecraft, the Mars Pathfinder, has a December launch date atop a Delta II booster. The mission features a lander and a microrover that will travel short distances over Martian territory. These missions usher in a new phase of Mars exploration, setting the stage for an unprecedented volley of spacecraft that will orbit around, land on, drive across, and perhaps fly at low altitudes over the planet.

  4. The sufficiency assumption of the reasoned approach to action

    Directory of Open Access Journals (Sweden)

    David Trafimow

    2015-12-01

    Full Text Available The reasoned action approach to understanding and predicting behavior includes the sufficiency assumption. Although variables not included in the theory may influence behavior, these variables work through the variables in the theory. Once the reasoned action variables are included in an analysis, the inclusion of other variables will not increase the variance accounted for in behavioral intentions or behavior. Reasoned action researchers are very concerned with testing if new variables account for variance (or how much traditional variables account for variance, to see whether they are important, in general or with respect to specific behaviors under investigation. But this approach tacitly assumes that accounting for variance is highly relevant to understanding the production of variance, which is what really is at issue. Based on the variance law, I question this assumption.

  5. Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose.

    Directory of Open Access Journals (Sweden)

    Michael M Scott

    Full Text Available The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability. Ghrelin, a peripherally produced peptide hormone, circulates at high concentrations during nutrient scarcity. Ghrelin promotes food intake, an action lost in ghrelin receptor null mice and also helps maintain fasting blood glucose levels, ensuring an adequate supply of nutrients to the central nervous system. To better understand mechanisms of ghrelin action, we have examined the roles of ghrelin receptor (GHSR expression in the mouse hindbrain. Notably, selective hindbrain ghrelin receptor expression was not sufficient to restore ghrelin-stimulated food intake. In contrast, the lowered fasting blood glucose levels observed in ghrelin receptor-deficient mice were returned to wild-type levels by selective re-expression of the ghrelin receptor in the hindbrain. Our results demonstrate the distributed nature of the neurons mediating ghrelin action.

  6. Lead–acid batteries coupled with photovoltaics for increased electricity self-sufficiency in households

    International Nuclear Information System (INIS)

    Oliveira e Silva de, Guilherme; Hendrick, Patrick

    2016-01-01

    Highlights: • Grid parity is reached for PV installations up to nearly 40% self-sufficiency. • Reaching beyond 40% self-sufficiency requires storage and support policies. • Peak consumption remains constant but load variability rises with self-sufficiency. • Changes in power plants portfolio and wholesale electricity prices are expected. • Limiting feed-in power is a promising solution for reducing load variability. - Abstract: With distributed generation of electricity growing in importance (especially with photovoltaics) and buildings being one of the main consumers of energy in modern societies, distributed storage of energy in buildings is expected to become increasingly present. This paper analyses the use of residential lead–acid energy storage coupled with photovoltaics and its possible interaction with the grid for different limits of feed-in power without any support policies. In the literature, these subjects are often treated independently and for very specific, non-optimised cases, thus motivating further research. Results show that reaching self-sufficiency values up to 40% is possible, close to grid parity values, and only with photovoltaics. Beyond 40%, energy storage must be used, strongly raising the cost of the electricity consumed and therefore the need for support policies for widespread adoption. Also, peak power consumption from the grid remains constant and load variability rises, suggesting that an increase in self-sufficiency would be accompanied by lower utilisation factors of power plants and, consequently, higher wholesale electricity prices during no sunshine hours. Limiting feed-in power attenuates the increased load variability and only slightly affects the economic viability of such installations. These results present a novel optimisation tool for developers and should be considered in future studies of distributed photovoltaics and energy storage as well as in energy policy.

  7. Toxicological comments to the discussion about REACH.

    Science.gov (United States)

    Greim, Helmut; Arand, Michael; Autrup, Herman; Bolt, Hermann M; Bridges, James; Dybing, Erik; Glomot, Rémi; Foa, Vito; Schulte-Hermann, Rolf

    2006-03-01

    It is the ultimate goal of the intended REACH process (Registration, Evaluation and Authorization of Chemicals) of the European Union to identify substances of hazardous properties and to evaluate the risks of human and environmental exposure. During the last few months there has been a controversial discussion as to what extent in vitro studies and consideration of structure activity relationship provide sufficient information to waive repeated exposure studies. Industry as well as certain regulatory agencies or NGOs support this approach and propose that repeated dose studies may only be required beyond 100 t/a. From a toxicological point of view it has to be stressed that this discussion primarily considers the cost reduction and protection of animals, whereas protection of human health and the environment are secondary. In vitro studies only allow identification of specific hazardous properties which can be detected by the specific test system. Moreover, appropriate information on the dose response of adverse effects, identification of thresholds and NOELs that are essential for risk characterization cannot be obtained from these studies. Consequently, identification of all relevant hazardous properties and endpoints of adverse effects can only be determined in the intact animal by repeated dose studies such as 28-day or 90-day studies. In the absence of such information the hazard identification is incomplete and there is no basis for appropriate risk assessment of human exposure. Thus, any waiving of repeated dose studies in animals bears the probability of unforeseen effects in case of acute or continuous human exposure. From this the undersigning European Toxicologists conclude: 1. The intention of REACH is to identify hazardous properties in order that a reliable risk assessment can be made and measures taken to deal with chemicals posing a significant risk. 2. The recent debate has centered on ways in which the well established in vivo methods for risk

  8. Has Silicon Reached It's Limit?

    Directory of Open Access Journals (Sweden)

    Alan John Charles Davidson

    2014-01-01

    Full Text Available In light of the rapidly increasing demand for ultra-high speed data transmission, data centres are under pressure to provide ever increasing data transmission through their networks and at the same time improve the quality of data handling in terms of reduced latency, increased scalability and improved channel speed for users. However as data rates increase, present electronic switching technology using current data centre architecture is becoming increasingly difficult to scale despite improvements in data management. In this paper the tremendous bandwidth potential of optical fibre based networks will be explored alongside the issues of electronic scalability and switching speed. A resulting need for alternative optical solutions for all-optical signal processing systems will be discussed. With this in mind, progress in the form of a novel and highly scalable optical interconnect will be reviewed.

  9. Sufficient conditions for Lagrange, Mayer, and Bolza optimization problems

    Directory of Open Access Journals (Sweden)

    Boltyanski V.

    2001-01-01

    Full Text Available The Maximum Principle [2,13] is a well known necessary condition for optimality. This condition, generally, is not sufficient. In [3], the author proved that if there exists regular synthesis of trajectories, the Maximum Principle also is a sufficient condition for time-optimality. In this article, we generalize this result for Lagrange, Mayer, and Bolza optimization problems.

  10. Sufficiency does energy consumption become a moral issue?

    Energy Technology Data Exchange (ETDEWEB)

    Muller, Adrian (Socio-economic Inst. and Univ. Research Priority Programme in Ethics, Univ. of Zuerich, Zuerich (Switzerland))

    2009-07-01

    Reducing the externalities from energy use is crucial for sustainability. There are basically four ways to reduce externalities from energy use: increasing technical efficiency ('energy input per unit energy service'), increasing economic efficiency ('internalising external costs'), using 'clean' energy sources with few externalities, or sufficiency ('identifying 'optimal' energy service levels'). A combination of those strategies is most promising for sustainable energy systems. However, the debate on sustainable energy is dominated by efficiency and clean energy strategies, while sufficiency plays a minor role. Efficiency and clean energy face several problems, though. Thus, the current debate should be complemented with a critical discussion of sufficiency. In this paper, I develop a concept of sufficiency, which is adequate for liberal societies. I focus on ethical foundations for sufficiency, as the discussion of such is missing or cursory only in the existing literature. I first show that many examples of sufficiency can be understood as (economic) efficiency, but that the two concepts do not coincide. I then show that sufficiency based on moralization of actions can be understood as implementation of the boundary conditions for social justice that come with notions of liberal societies, in particular the duty not to harm other people. By this, to increase sufficiency becomes a duty beyond individual taste. I further illustrate this in the context of the adverse effects of climate change as externalities from energy use.

  11. Improving the Perception of Self-Sufficiency towards Creative Drama

    Science.gov (United States)

    Pekdogan, Serpil; Korkmaz, Halil Ibrahim

    2016-01-01

    The purpose of this study is to investigate the effects of a Creative Drama Based Perception of Self-sufficiency Skills Training Program on 2nd grade bachelor degree students' (who are attending a preschool teacher training program) perception of self-sufficiency. This is a quasi-experimental study. Totally 50 students were equally divided into…

  12. Operational Reach: Is Current Army Doctrine Adequate?

    National Research Council Canada - National Science Library

    Heintzelman, Scott

    2003-01-01

    The term operational reach, an element of operational design, is new to U.S. Army doctrine. Operational reach is not found in the previous edition of the Army's basic operational doctrine, Field Manual...

  13. Stream Habitat Reach Summary - NCWAP [ds158

    Data.gov (United States)

    California Natural Resource Agency — The Stream Habitat - NCWAP - Reach Summary [ds158] shapefile contains in-stream habitat survey data summarized to the stream reach level. It is a derivative of the...

  14. Adaptive mixed reality rehabilitation improves quality of reaching movements more than traditional reaching therapy following stroke.

    Science.gov (United States)

    Duff, Margaret; Chen, Yinpeng; Cheng, Long; Liu, Sheng-Min; Blake, Paul; Wolf, Steven L; Rikakis, Thanassis

    2013-05-01

    Adaptive mixed reality rehabilitation (AMRR) is a novel integration of motion capture technology and high-level media computing that provides precise kinematic measurements and engaging multimodal feedback for self-assessment during a therapeutic task. We describe the first proof-of-concept study to compare outcomes of AMRR and traditional upper-extremity physical therapy. Two groups of participants with chronic stroke received either a month of AMRR therapy (n = 11) or matched dosing of traditional repetitive task therapy (n = 10). Participants were right handed, between 35 and 85 years old, and could independently reach to and at least partially grasp an object in front of them. Upper-extremity clinical scale scores and kinematic performances were measured before and after treatment. Both groups showed increased function after therapy, demonstrated by statistically significant improvements in Wolf Motor Function Test and upper-extremity Fugl-Meyer Assessment (FMA) scores, with the traditional therapy group improving significantly more on the FMA. However, only participants who received AMRR therapy showed a consistent improvement in kinematic measurements, both for the trained task of reaching to grasp a cone and the untrained task of reaching to push a lighted button. AMRR may be useful in improving both functionality and the kinematics of reaching. Further study is needed to determine if AMRR therapy induces long-term changes in movement quality that foster better functional recovery.

  15. Enough is as good as a feast - sufficiency as policy

    Energy Technology Data Exchange (ETDEWEB)

    Darby, Sarah [Lower Carbon Futures, Environmental Change Inst., Oxford Univ. Centre for the Environment (United Kingdom)

    2007-07-01

    The concept of sufficiency has a long history, related as it is to the timeless issues of how best to distribute and use resources. Where energy is concerned, absolute reductions in demand are increasingly seen as necessary in response to climate change and energy security concerns. There is an acknowledgement that, collectively if not individually, humans have gone beyond safe limits in their use of fuels. The relatively wealthy and industrialised nations urgently need to move beyond a primary focus on efficiency to the more contentious issues surrounding demand reduction and sufficiency. The paper considers definitions of energy sufficiency, looks at a recent attempt to model future energy use in terms of efficiency and sufficiency, and discusses quantitative and qualitative aspects of sufficiency and how they might become institutionalised. There are many arguments in favour of sufficiency but they often founder in the face of political requirements for market growth and the employment generated by it. Some options for 'sufficiency policy' are selected, including a focus on energy in relation to livelihoods, energy implications of our use of time and making energy use more transparent.

  16. Can donated media placements reach intended audiences?

    Science.gov (United States)

    Cooper, Crystale Purvis; Gelb, Cynthia A; Chu, Jennifer; Polonec, Lindsey

    2013-09-01

    Donated media placements for public service announcements (PSAs) can be difficult to secure, and may not always reach intended audiences. Strategies used by the Centers for Disease Control and Prevention's (CDC) Screen for Life: National Colorectal Cancer Action Campaign (SFL) to obtain donated media placements include producing a diverse mix of high-quality PSAs, co-branding with state and tribal health agencies, securing celebrity involvement, monitoring media trends to identify new distribution opportunities, and strategically timing the release of PSAs. To investigate open-ended recall of PSAs promoting colorectal cancer screening, CDC conducted 12 focus groups in three U.S. cities with men and women either nearing age 50 years, when screening is recommended to begin, or aged 50-75 years who were not in compliance with screening guidelines. In most focus groups, multiple participants recalled exposure to PSAs promoting colorectal cancer screening, and most of these individuals reported having seen SFL PSAs on television, in transit stations, or on the sides of public buses. Some participants reported exposure to SFL PSAs without prompting from the moderator, as they explained how they learned about the disease. Several participants reported learning key campaign messages from PSAs, including that colorectal cancer screening should begin at age 50 years and screening can find polyps so they can be removed before becoming cancerous. Donated media placements can reach and educate mass audiences, including millions of U.S. adults who have not been screened appropriately for colorectal cancer.

  17. Evolution favors protein mutational robustness in sufficiently large populations

    Directory of Open Access Journals (Sweden)

    Venturelli Ophelia S

    2007-07-01

    Full Text Available Abstract Background An important question is whether evolution favors properties such as mutational robustness or evolvability that do not directly benefit any individual, but can influence the course of future evolution. Functionally similar proteins can differ substantially in their robustness to mutations and capacity to evolve new functions, but it has remained unclear whether any of these differences might be due to evolutionary selection for these properties. Results Here we use laboratory experiments to demonstrate that evolution favors protein mutational robustness if the evolving population is sufficiently large. We neutrally evolve cytochrome P450 proteins under identical selection pressures and mutation rates in populations of different sizes, and show that proteins from the larger and thus more polymorphic population tend towards higher mutational robustness. Proteins from the larger population also evolve greater stability, a biophysical property that is known to enhance both mutational robustness and evolvability. The excess mutational robustness and stability is well described by mathematical theory, and can be quantitatively related to the way that the proteins occupy their neutral network. Conclusion Our work is the first experimental demonstration of the general tendency of evolution to favor mutational robustness and protein stability in highly polymorphic populations. We suggest that this phenomenon could contribute to the mutational robustness and evolvability of viruses and bacteria that exist in large populations.

  18. Predator confusion is sufficient to evolve swarming behaviour.

    Science.gov (United States)

    Olson, Randal S; Hintze, Arend; Dyer, Fred C; Knoester, David B; Adami, Christoph

    2013-08-06

    Swarming behaviours in animals have been extensively studied owing to their implications for the evolution of cooperation, social cognition and predator-prey dynamics. An important goal of these studies is discerning which evolutionary pressures favour the formation of swarms. One hypothesis is that swarms arise because the presence of multiple moving prey in swarms causes confusion for attacking predators, but it remains unclear how important this selective force is. Using an evolutionary model of a predator-prey system, we show that predator confusion provides a sufficient selection pressure to evolve swarming behaviour in prey. Furthermore, we demonstrate that the evolutionary effect of predator confusion on prey could in turn exert pressure on the structure of the predator's visual field, favouring the frontally oriented, high-resolution visual systems commonly observed in predators that feed on swarming animals. Finally, we provide evidence that when prey evolve swarming in response to predator confusion, there is a change in the shape of the functional response curve describing the predator's consumption rate as prey density increases. Thus, we show that a relatively simple perceptual constraint--predator confusion--could have pervasive evolutionary effects on prey behaviour, predator sensory mechanisms and the ecological interactions between predators and prey.

  19. REACH: impact on the US cosmetics industry?

    Science.gov (United States)

    Pouillot, Anne; Polla, Barbara; Polla, Ada

    2009-03-01

    The Registration, Evaluation, Authorization and restriction of Chemicals (REACH) is a recent European regulation on chemical substances meant to protect human health and the environment. REACH imposes the "precautionary principle" where additional data and definitive action are required when uncertainty is identified. The cosmetics industry is only partially concerned by REACH: while the stages of registration and evaluation apply to cosmetics, those of authorization and restriction most likely will not, as cosmetic ingredients are already subject to regulation by various agencies and directives. REACH has potential benefits to the industry including the possibility of reassuring consumers and improving their image of chemicals and cosmetics. However, REACH also has potential disadvantages, mainly with regard to impeding innovation. The American cosmetics industry will be affected by REACH, because all US manufacturers who export substances to Europe will have to fully comply with REACH.

  20. New Sufficient LMI Conditions for Static Output Stabilization

    DEFF Research Database (Denmark)

    Adegas, Fabiano Daher

    2014-01-01

    This paper presents new linear matrix inequality conditions to the static output feedback stabilization problem. Although the conditions are only sufficient, numerical experiments show excellent success rates in finding a stabilizing controller....

  1. Modelling cereal crops to assess future climate risk for family food self-sufficiency in southern Mali

    NARCIS (Netherlands)

    Traore, Bouba; Descheemaeker, Katrien; Wijk, van Mark T.; Corbeels, Marc; Supit, Iwan; Giller, Ken E.

    2017-01-01

    Future climate change will have far reaching consequences for smallholder farmers in sub-Saharan Africa, the majority of whom depend on agriculture for their livelihoods. Here we assessed the farm-level impact of climate change on family food self-sufficiency and evaluated potential adaptation

  2. Sustainability and energy self-sufficiency; overcoming the barriers

    Directory of Open Access Journals (Sweden)

    Rania Abdel Galil

    2015-12-01

    Full Text Available Engendering more positive attitudes to renewable energy is by no means a simple feat. Renewable energy technologies are viewed as radical innovations which necessitate substantial changes in production and consumption patterns, hence often met with resistance from both institutions and individuals. Yet action is needed; global energy consumption is expected to rise by 41% and global carbon dioxide emissions by 29%, with most of the demand and rise coming from emerging economies (BP energy outlook 2035. Further, countries need to meet objectives of reduction of GHG under the United Nations Framework Convention on Climate Change. Renewable energy share in the global energy mix needs to significantly increase in order to reach supply sufficiency, energy security, energy equity and environmental sustainability.Meeting demands of energy is critical for the economic and social development of any country; energy must be secure, accessible and affordable at all levels of society, and any negative impact of energy production and energy use on the environment must be minimized. Middle East energy consumption is expected to grow by 69% whilst production to grow by 32%, with 97% of demand still met by fossil fuels by the end of the 2035. Energy investment of $316 billion will be required in the Middle East and North Africa (MENA between 2015 and 2019 to meet its growing demand for power (Apicorp, 2014. Diversifying energy sources is indeed of interest in the MENA region, spurred by growing demand for power and desalinated water, fluctuating fuel price, GHG emission reduction targets, depleting fossil fuel reserves and advances in renewable energy technology. However, there are many barriers that hinder the adoption of renewable energy technologies worldwide, but more so in the MENA region. These barriers are political, economic, social and technological. With a focus on Europe and MENA, it can be said that these barriers have much in common albeit framing

  3. Micronutrients in the life cycle: Requirements and sufficient supply

    Directory of Open Access Journals (Sweden)

    K. Biesalski Hans

    2018-06-01

    Full Text Available Macronutrients (fat, protein, carbohydrates deliver energy and important material to ensure the entire body composition. Micronutrients are needed to keep this process of continuous construction and re-construction running. Consequently, the requirement for micronutrients will differ depending on the individual need which is related to the different metabolic conditions within the life cycle. Within the first 1000 days of life, from conception to the end of the second year of life the requirement for micronutrients is high and if the supply is inadequate that might have consequences for physical and at least cognitive development. In particular, iron, iodine, vitamin D and folate are micronutrients which might become critical during that period. Due to the fact that clinical symptoms of deficiencies develop late, but inadequate supply of one or more micronutrients may have consequences for health the term hidden hunger has been introduced to describe that situation. In particular the time period of pregnancy and early childhood is critical and hidden hunger is a worldwide problem, affecting >2 billion people, primarily females and children. The importance of different requirements during the life cycle is usually not considered. In addition, we do not really know what the individual requirement is. The estimation of the requirement is based on studies calculating the supply of a micronutrient to avoid a deficiency disease within a healthy population and is not based on sound scientific methodology or data. We need to consider that at different moments in the life cycle the supply might become critical in particular in case of a disease or sudden increase of metabolic turnover. In this narrative review we summarize data from studies dealing with different micronutrient requirements in pregnancy, exercise, vegan diet, adolescents and elderly. Knowledge of critical periods and related critical micronutrients might help to avoid hidden hunger and

  4. Working memory maintenance is sufficient to reduce state anxiety.

    Science.gov (United States)

    Balderston, Nicholas L; Quispe-Escudero, David; Hale, Elizabeth; Davis, Andrew; O'Connell, Katherine; Ernst, Monique; Grillon, Christian

    2016-11-01

    According to the attentional control theory (ACT) proposed by Eysenck and colleagues, anxiety interferes with cognitive processing by prioritizing bottom-up attentional processes over top-down attentional processes, leading to competition for access to limited resources in working memory, particularly the central executive (Eysenck, Derakshan, Santos, & Calvo, ). However, previous research using the n-back working memory task suggests that working memory load also reduces state anxiety. Assuming that similar mechanisms underlie the effect of anxiety on cognition, and the effect of cognition on anxiety, one possible implication of the ACT would suggest that the reduction of state anxiety with increasing working memory load is driven by activation of central executive attentional control processes. We tested this hypothesis using the Sternberg working memory paradigm, where maintenance processes can be isolated from central executive processes (Altamura et al., ; Sternberg, ). Consistent with the n-back results, subjects showed decreased state anxiety during the maintenance period of high-load trials relative to low-load trials, suggesting that maintenance processes alone are sufficient to achieve this state anxiety reduction. Given that the Sternberg task does not require central executive engagement, these results are not consistent with an implication of the ACT where the cognition/anxiety relationship and anxiety/cognition relationship are mediated by similar central executive mechanisms. Instead, we propose an extension of the ACT such that engaging working memory maintenance suppresses state anxiety in a load-dependent manner. Furthermore, we hypothesize that the efficacy of this effect may moderate the effect of trait anxiety on cognition. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

  5. Empowering people. Alleviating poverty through self-sufficiency.

    Science.gov (United States)

    Nahariya, R

    1993-03-01

    Highlights from an interview with Benjamin D. de Leon, who was appointed Presidential Assistant for Social Development in the Philippines in September 1992, are presented. Mr. de Leon's concern for the marginal sectors of society in health, employment, housing, social welfare, and manpower training as well as his goals of poverty alleviation and people empowerment account for this appointment. Duties include formulating a social development agenda; assisting the Social Development Committee of the Cabinet and the National Economic Development Authority (NEDA) in program implementation; and providing weekly information packages about family planning (FP), health, children, women, and the environment. The social development agenda of the Philippine Medium-term Plan (1992-1998) includes employment, income, wages; population, health and nutrition, and family planning; and housing, education, manpower development, social welfare, and community development. The Plan recognizes that poverty is aggravated by rapid population growth, and it strives to ensure that adolescents, military males, high-risk women, and young unmarried couples receive FP information and services from government agencies and nongovernmental organizations. Adequate resources for population and FP as well as recognizing the relationship among population, resources, and the environment are essential to meet the goals of the plan. The present population and FP policy is based on the 1987 Constitution, which spells out responsible parenthood but also rejects abortion as a method of contraception. The official FP program calls for child survival and safe motherhood and accessible, available, and affordable FP services. The Roman Catholic Church opposes the program, since the Church promotes only the rhythm method, but the other religions approve of the program. Some priests and nuns did not object to the promotion of FP. Sufficient financial support from the international community for the Philippine

  6. Decoding complete reach and grasp actions from local primary motor cortex populations.

    Science.gov (United States)

    Vargas-Irwin, Carlos E; Shakhnarovich, Gregory; Yadollahpour, Payman; Mislow, John M K; Black, Michael J; Donoghue, John P

    2010-07-21

    How the activity of populations of cortical neurons generates coordinated multijoint actions of the arm, wrist, and hand is poorly understood. This study combined multielectrode recording techniques with full arm motion capture to relate neural activity in primary motor cortex (M1) of macaques (Macaca mulatta) to arm, wrist, and hand postures during movement. We find that the firing rate of individual M1 neurons is typically modulated by the kinematics of multiple joints and that small, local ensembles of M1 neurons contain sufficient information to reconstruct 25 measured joint angles (representing an estimated 10 functionally independent degrees of freedom). Beyond showing that the spiking patterns of local M1 ensembles represent a rich set of naturalistic movements involving the entire upper limb, the results also suggest that achieving high-dimensional reach and grasp actions with neuroprosthetic devices may be possible using small intracortical arrays like those already being tested in human pilot clinical trials.

  7. The level of energy sufficiency - why all the controversy?

    International Nuclear Information System (INIS)

    Maillard, D.

    2000-01-01

    It as become fashionable in certain circles to attempt to demolish the notion of energy sufficiency, a concept which is now seen as being archaic and unsuitable. To back up their claims, proponents of this standpoint take great pleasure in attacking the corresponding indicator - the rate of energy sufficiency calculated as a ratio of national primary energy production and the total consumption of primary energy (in the same unit and without climatic corrections). Confirming its precarious, conventional and debatable nature seems in their eyes to be the best means of ensuring that both the word, the concept and the measuring method of energy sufficiency are consigned to the dustbin of economic history. After having examined with perhaps a certain irony some of the usual criticisms, I intend to proceed with a re-examination of questions which in my eyes appear to be essential. (author)

  8. Global Sufficient Optimality Conditions for a Special Cubic Minimization Problem

    Directory of Open Access Journals (Sweden)

    Xiaomei Zhang

    2012-01-01

    Full Text Available We present some sufficient global optimality conditions for a special cubic minimization problem with box constraints or binary constraints by extending the global subdifferential approach proposed by V. Jeyakumar et al. (2006. The present conditions generalize the results developed in the work of V. Jeyakumar et al. where a quadratic minimization problem with box constraints or binary constraints was considered. In addition, a special diagonal matrix is constructed, which is used to provide a convenient method for justifying the proposed sufficient conditions. Then, the reformulation of the sufficient conditions follows. It is worth noting that this reformulation is also applicable to the quadratic minimization problem with box or binary constraints considered in the works of V. Jeyakumar et al. (2006 and Y. Wang et al. (2010. Finally some examples demonstrate that our optimality conditions can effectively be used for identifying global minimizers of the certain nonconvex cubic minimization problem.

  9. Quantification is Neither Necessary Nor Sufficient for Measurement

    International Nuclear Information System (INIS)

    Mari, Luca; Maul, Andrew; Torres Irribarra, David; Wilson, Mark

    2013-01-01

    Being an infrastructural, widespread activity, measurement is laden with stereotypes. Some of these concern the role of measurement in the relation between quality and quantity. In particular, it is sometimes argued or assumed that quantification is necessary for measurement; it is also sometimes argued or assumed that quantification is sufficient for or synonymous with measurement. To assess the validity of these positions the concepts of measurement and quantitative evaluation should be independently defined and their relationship analyzed. We contend that the defining characteristic of measurement should be the structure of the process, not a feature of its results. Under this perspective, quantitative evaluation is neither sufficient nor necessary for measurement

  10. REACH: Evaluation Report and Executive Summary

    Science.gov (United States)

    Sibieta, Luke

    2016-01-01

    REACH is a targeted reading support programme designed to improve reading accuracy and comprehension in pupils with reading difficulties in Years 7 and 8. It is based on research by the Centre for Reading and Language at York and is delivered by specially trained teaching assistants (TAs). This evaluation tested two REACH interventions, one based…

  11. Economic Valuation of Sufficient and Guaranteed Irrigation Water Supply for Paddy Farms of Guilan Province

    Directory of Open Access Journals (Sweden)

    Mohammad Kavoosi Kalashami

    2014-08-01

    Full Text Available Cultivation of the strategic crop of rice highly depends to the existence of sufficient and guaranteed irrigation water, and water shortage stresses have irreparable effects on yield and quality of productions. Decrease of the Sefidrud river inflow in Guilan province which is the main source of supplying irrigation water for 171 thousand hectares under rice cropping area of this province, has been challenged sufficient and guaranteed irrigation water supply in many regions of mentioned province. Hence, in present study estimating the value that paddy farmers place on sufficient and guaranteed irrigation water supply has been considered. Economic valuation of sufficient and guaranteed irrigation water supply improves water resource management policies in demand side. Requested data set were obtained on the base of a survey and are collected from 224 paddy farms in rural regions that faced with irrigation water shortages. Then, using open-ended valuation approach and estimation of Tobit model via ML and two stages Heckman approach, eliciting paddy farmers' willingness to pay for sufficient and guaranteed irrigation water supply has been accomplished. Results revealed that farmers in investigated regions willing to pay 26.49 percent more than present costs of providing irrigation water in order to have sufficient and guaranteed irrigation water.

  12. Online Learning in Higher Education: Necessary and Sufficient Conditions

    Science.gov (United States)

    Lim, Cher Ping

    2005-01-01

    The spectacular development of information and communication technologies through the Internet has provided opportunities for students to explore the virtual world of information. In this article, the author discusses the necessary and sufficient conditions for successful online learning in educational institutions. The necessary conditions…

  13. Intellectual Freedom and Economic Sufficiency as Educational Entitlements.

    Science.gov (United States)

    Morse, Jane Fowler

    2001-01-01

    Using the theories of John Stuart Mill and Karl Marx, this article supports the educational entitlements of intellectual freedom and economic sufficiency. Explores these issues in reference to their implications for teaching, the teaching profession and its training. Concludes that ideas cannot be controlled by the interests of the dominant class.…

  14. Towards a sufficiency-driven business model : Experiences and opportunities

    NARCIS (Netherlands)

    Bocken, N.M.P.; Short, SW

    2016-01-01

    Business model innovation is an important lever for change to tackle pressing sustainability issues. In this paper, ‘sufficiency’ is proposed as a driver of business model innovation for sustainability. Sufficiency-driven business models seek to moderate overall resource consumption by curbing

  15. Proprioceptive body illusions modulate the visual perception of reaching distance.

    Directory of Open Access Journals (Sweden)

    Agustin Petroni

    Full Text Available The neurobiology of reaching has been extensively studied in human and non-human primates. However, the mechanisms that allow a subject to decide-without engaging in explicit action-whether an object is reachable are not fully understood. Some studies conclude that decisions near the reach limit depend on motor simulations of the reaching movement. Others have shown that the body schema plays a role in explicit and implicit distance estimation, especially after motor practice with a tool. In this study we evaluate the causal role of multisensory body representations in the perception of reachable space. We reasoned that if body schema is used to estimate reach, an illusion of the finger size induced by proprioceptive stimulation should propagate to the perception of reaching distances. To test this hypothesis we induced a proprioceptive illusion of extension or shrinkage of the right index finger while participants judged a series of LEDs as reachable or non-reachable without actual movement. Our results show that reach distance estimation depends on the illusory perceived size of the finger: illusory elongation produced a shift of reaching distance away from the body whereas illusory shrinkage produced the opposite effect. Combining these results with previous findings, we suggest that deciding if a target is reachable requires an integration of body inputs in high order multisensory parietal areas that engage in movement simulations through connections with frontal premotor areas.

  16. The database for reaching experiments and models.

    Directory of Open Access Journals (Sweden)

    Ben Walker

    Full Text Available Reaching is one of the central experimental paradigms in the field of motor control, and many computational models of reaching have been published. While most of these models try to explain subject data (such as movement kinematics, reaching performance, forces, etc. from only a single experiment, distinct experiments often share experimental conditions and record similar kinematics. This suggests that reaching models could be applied to (and falsified by multiple experiments. However, using multiple datasets is difficult because experimental data formats vary widely. Standardizing data formats promises to enable scientists to test model predictions against many experiments and to compare experimental results across labs. Here we report on the development of a new resource available to scientists: a database of reaching called the Database for Reaching Experiments And Models (DREAM. DREAM collects both experimental datasets and models and facilitates their comparison by standardizing formats. The DREAM project promises to be useful for experimentalists who want to understand how their data relates to models, for modelers who want to test their theories, and for educators who want to help students better understand reaching experiments, models, and data analysis.

  17. Media perspective - new opportunities for reaching audiences

    Science.gov (United States)

    Haswell, Katy

    2007-08-01

    The world of media is experiencing a period of extreme and rapid change with the rise of internet television and the download generation. Many young people no longer watch standard TV. Instead, they go on-line, talking to friends and downloading pictures, videos, music clips to put on their own websites and watch/ listen to on their laptops and mobile phones. Gone are the days when TV controllers determined what you watched and when you watched it. Now the buzzword is IPTV, Internet Protocol Television, with companies such as JOOST offering hundreds of channels on a wide range of subjects, all of which you can choose to watch when and where you wish, on your high-def widescreen with stereo surround sound at home or on your mobile phone on the train. This media revolution is changing the way organisations get their message out. And it is encouraging companies such as advertising agencies to be creative about new ways of accessing audiences. The good news is that we have fresh opportunities to reach young people through internet-based media and material downloaded through tools such as games machines, as well as through the traditional media. And it is important for Europlanet to make the most of these new and exciting developments.

  18. Important ATLAS Forward Calorimeter Milestone Reached

    CERN Document Server

    Loch, P.

    The ATLAS Forward Calorimeter working group has reached an important milestone in the production of their detectors. The mechanical assembly of the first electromagnetic module (FCal1C) has been completed at the University of Arizona on February 25, 2002, only ten days after the originally scheduled date. The photo shows the University of Arizona FCal group in the clean room, together with the assembled FCal1C module. The module consists of a stack of 18 round copper plates, each about one inch thick. Each plate is about 90 cm in diameter, and has 12260 precision-drilled holes in it, to accommodate the tube/rod electrode assembly. The machining of the plates, which was done at the Science Technology Center (STC) at Carleton University, Ottawa, Canada, required high precision to allow for easy insertion of the electrode copper tube. The plates have been carefully cleaned at the University of Arizona, to remove any machining residue and metal flakes. This process alone took about eleven weeks. Exactly 122...

  19. Reaching Hard-to-Reach Individuals: Nonselective Versus Targeted Outbreak Response Vaccination for Measles

    Science.gov (United States)

    Minetti, Andrea; Hurtado, Northan; Grais, Rebecca F.; Ferrari, Matthew

    2014-01-01

    Current mass vaccination campaigns in measles outbreak response are nonselective with respect to the immune status of individuals. However, the heterogeneity in immunity, due to previous vaccination coverage or infection, may lead to potential bias of such campaigns toward those with previous high access to vaccination and may result in a lower-than-expected effective impact. During the 2010 measles outbreak in Malawi, only 3 of the 8 districts where vaccination occurred achieved a measureable effective campaign impact (i.e., a reduction in measles cases in the targeted age groups greater than that observed in nonvaccinated districts). Simulation models suggest that selective campaigns targeting hard-to-reach individuals are of greater benefit, particularly in highly vaccinated populations, even for low target coverage and with late implementation. However, the choice between targeted and nonselective campaigns should be context specific, achieving a reasonable balance of feasibility, cost, and expected impact. In addition, it is critical to develop operational strategies to identify and target hard-to-reach individuals. PMID:24131555

  20. Enhancing US Operational Reach in Southeast Asia

    National Research Council Canada - National Science Library

    Hitchcock, David

    2003-01-01

    .... While this treat continues to exist, the US Pacific Command (PACOM) must also pursue a neat term methodology to expand its operational reach and ability to respond to contingencies throughout the East Asian littoral, especially within Southeast Asia...

  1. Reaching the Overlooked Student in Physical Education

    Science.gov (United States)

    Esslinger, Keri; Esslinger, Travis; Bagshaw, Jarad

    2015-01-01

    This article describes the use of live action role-playing, or "LARPing," as a non-traditional activity that has the potential to reach students who are not interested in traditional physical education.

  2. Compact muon solenoid magnet reaches full field

    CERN Multimedia

    2006-01-01

    Scientist of the U.S. Department of Energy in Fermilab and collaborators of the US/CMS project announced that the world's largest superconducting solenoid magnet has reached full field in tests at CERN. (1 apge)

  3. Assessing sufficient capability: A new approach to economic evaluation.

    Science.gov (United States)

    Mitchell, Paul Mark; Roberts, Tracy E; Barton, Pelham M; Coast, Joanna

    2015-08-01

    Amartya Sen's capability approach has been discussed widely in the health economics discipline. Although measures have been developed to assess capability in economic evaluation, there has been much less attention paid to the decision rules that might be applied alongside. Here, new methods, drawing on the multidimensional poverty and health economics literature, are developed for conducting economic evaluation within the capability approach and focusing on an objective of achieving "sufficient capability". This objective more closely reflects the concern with equity that pervades the capability approach and the method has the advantage of retaining the longitudinal aspect of estimating outcome that is associated with quality-adjusted life years (QALYs), whilst also drawing on notions of shortfall associated with assessments of poverty. Economic evaluation from this perspective is illustrated in an osteoarthritis patient group undergoing joint replacement, with capability wellbeing assessed using ICECAP-O. Recommendations for taking the sufficient capability approach forward are provided. Copyright © 2015 Elsevier Ltd. All rights reserved.

  4. Entrepreneurship by any other name: self-sufficiency versus innovation.

    Science.gov (United States)

    Parker Harris, Sarah; Caldwell, Kate; Renko, Maija

    2014-01-01

    Entrepreneurship has been promoted as an innovative strategy to address the employment of people with disabilities. Research has predominantly focused on the self-sufficiency aspect without fully integrating entrepreneurship literature in the areas of theory, systems change, and demonstration projects. Subsequently there are gaps in services, policies, and research in this field that, in turn, have limited our understanding of the support needs and barriers or facilitators of entrepreneurs with disabilities. A thorough analysis of the literature in these areas led to the development of two core concepts that need to be addressed in integrating entrepreneurship into disability employment research and policy: clarity in operational definitions and better disability statistics and outcome measures. This article interrogates existing research and policy efforts in this regard to argue for a necessary shift in the field from focusing on entrepreneurship as self-sufficiency to understanding entrepreneurship as innovation.

  5. Pricing and crude oil self-sufficiency. [Canada

    Energy Technology Data Exchange (ETDEWEB)

    1979-11-01

    How Canada should go about achieving crude oil self-sufficiency and who should develop Canada's petroleum resources are discussed. The degree of urgency and the level of commitment required by government, industry, and consumers are evaluated. What the price should be of Canadian crude oil and who should establish this price are also discussed. The economic aspects of investment, return, and taxation are also included. (DC)

  6. Reassessing Rogers' necessary and sufficient conditions of change.

    Science.gov (United States)

    Watson, Jeanne C

    2007-09-01

    This article reviews the impact of Carl Rogers' postulate about the necessary and sufficient conditions of therapeutic change on the field of psychotherapy. It is proposed that his article (see record 2007-14630-002) made an impact in two ways; first, by acting as a spur to researchers to identify the active ingredients of therapeutic change; and, second, by providing guidelines for therapeutic practice. The role of the necessary and sufficient conditions in process-experiential therapy, an emotion-focused therapy for individuals, and their limitations in terms of research and practice are discussed. It is proposed that although the conditions are necessary and important in promoting clients' affect regulation, they do not take sufficient account of other moderating variables that affect clients' response to treatment and may need to be balanced with more structured interventions. Notwithstanding, Rogers highlighted a way of interacting with clients that is generally acknowledged as essential to effective psychotherapy practice. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  7. Sufficient conditions for uniqueness of the weak value

    International Nuclear Information System (INIS)

    Dressel, J; Jordan, A N

    2012-01-01

    We review and clarify the sufficient conditions for uniquely defining the generalized weak value as the weak limit of a conditioned average using the contextual values formalism introduced in Dressel, Agarwal and Jordan (2010 Phys. Rev. Lett. http://dx.doi.org/10.1103/PhysRevLett.104.240401). We also respond to criticism of our work by Parrott (arXiv:1105.4188v1) concerning a proposed counter-example to the uniqueness of the definition of the generalized weak value. The counter-example does not satisfy our prescription in the case of an underspecified measurement context. We show that when the contextual values formalism is properly applied to this example, a natural interpretation of the measurement emerges and the unique definition in the weak limit holds. We also prove a theorem regarding the uniqueness of the definition under our sufficient conditions for the general case. Finally, a second proposed counter-example by Parrott (arXiv:1105.4188v6) is shown not to satisfy the sufficiency conditions for the provided theorem. (paper)

  8. Sufficient Flexibility and Capacity in Electricity Markets with Renewables: A Review of Innovative Market Mechanisms

    DEFF Research Database (Denmark)

    Sekamane, Jonas Khubute; Katz, Jonas; Skytte, Klaus

    2017-01-01

    This review of the literature collects innovative market mechanisms that tend to get overlooked in the discussion of whether unassisted energy-only markets can ensure sufficient capacity or if capacity remuneration mechanisms are required. The paper complements existing literature reviews...... and pinpoints advantageous research areas relating to the market design of electricity systems with high shares of variable renewable energy...

  9. Faculty Sufficiency and AACSB Accreditation Compliance within a Global University: A Mathematical Modeling Approach

    Science.gov (United States)

    Boronico, Jess; Murdy, Jim; Kong, Xinlu

    2014-01-01

    This manuscript proposes a mathematical model to address faculty sufficiency requirements towards assuring overall high quality management education at a global university. Constraining elements include full-time faculty coverage by discipline, location, and program, across multiple campus locations subject to stated service quality standards of…

  10. Information trimming: Sufficient statistics, mutual information, and predictability from effective channel states

    Science.gov (United States)

    James, Ryan G.; Mahoney, John R.; Crutchfield, James P.

    2017-06-01

    One of the most basic characterizations of the relationship between two random variables, X and Y , is the value of their mutual information. Unfortunately, calculating it analytically and estimating it empirically are often stymied by the extremely large dimension of the variables. One might hope to replace such a high-dimensional variable by a smaller one that preserves its relationship with the other. It is well known that either X (or Y ) can be replaced by its minimal sufficient statistic about Y (or X ) while preserving the mutual information. While intuitively reasonable, it is not obvious or straightforward that both variables can be replaced simultaneously. We demonstrate that this is in fact possible: the information X 's minimal sufficient statistic preserves about Y is exactly the information that Y 's minimal sufficient statistic preserves about X . We call this procedure information trimming. As an important corollary, we consider the case where one variable is a stochastic process' past and the other its future. In this case, the mutual information is the channel transmission rate between the channel's effective states. That is, the past-future mutual information (the excess entropy) is the amount of information about the future that can be predicted using the past. Translating our result about minimal sufficient statistics, this is equivalent to the mutual information between the forward- and reverse-time causal states of computational mechanics. We close by discussing multivariate extensions to this use of minimal sufficient statistics.

  11. REACH: next step to a sound chemicals management.

    Science.gov (United States)

    Van der Wielen, Arnold

    2007-12-01

    REACH is the new European Regulation for Registration, Evaluation, Authorisation and Restriction of Chemicals. It entered into force on 1st June 2007 to streamline and improve the former legislative framework on new and on existing chemical substances of the European Union. Companies which manufacture or import more than 1 tonne of a substance per year will be required to register the substance at the new EU Chemicals Agency located in Helsinki. REACH places greater responsibility on industry to manage the risks that chemicals may pose to the health and the environment and to provide safety information that will be passed down the supply chain. In principle, REACH applies to all chemicals as such, as components in preparations and as used in articles. REACH is a radical step forward in the EU chemicals management. The onus will move from the authorities to industry. In addition, REACH will allow the further evaluation of substances where there are grounds for concern, foresees an authorisation system for the use of substances of very high concern and a system of restrictions, where applicable, for substances of concern. The Authorisation system will require companies to switch progressively to safer alternatives where a suitable alternative exists. Current use restrictions will remain under REACH system.

  12. When Does the Warmest Water Reach Greenland?

    Science.gov (United States)

    Grist, J. P.; Josey, S. A.; Boehme, L.; Meredith, M. P.; Laidre, K. L.; Heide-Jørgensen, M. P.; Kovacs, K. M.; Lydersen, C.; Davidson, F. J. M.; Stenson, G. B.; Hammill, M. O.; Marsh, R.; Coward, A.

    2016-02-01

    The warmest water reaching the east and west coast of Greenland is found between 200 and 600 m, in the warm Atlantic Water Layer (WL). Temperature changes within the WL have been highlighted as a possible cause of accelerated melting of tidewater glaciers and therefore are an important consideration for understanding global sea level rise. However, a limited number of winter observations of the WL have prohibited determining its seasonal variability. To address this, temperature data from Argo profiling floats, a range of sources within the World Ocean Database, and unprecedented coverage from marine-mammal borne sensors have been analyzed for the period 2002-2011. A significant seasonal range in temperature ( 1-2°C) is found in the warm layer, in contrast to most of the surrounding ocean. The magnitude of the seasonal cycle is thus comparable with the 1990s warming that was associated with an increased melt rate in a marine terminating glacier of West Greenland. The phase of the seasonal cycle exhibits considerable spatial variability; with high-resolution ocean model trajectory analysis suggesting it is determined by the time taken for waters to be advected from the subduction site in the Irminger Basin. For western Greenland, the annual temperature maximum occurs near or after the turn of the calendar year. This is significant because a recent study suggested that it is in the non-summer months when fjord-shelf exchanges allow the WL to most strongly influence glacier melt rate. However this is also the time of the year when the WL is least well observed. It is therefore clear that year-round subsurface temperature measurements are still required for a complete description of the WL seasonality, and in particular to ensure that the ice-melting potential of the WL is not underestimated.

  13. Decoding natural reach-and-grasp actions from human EEG

    Science.gov (United States)

    Schwarz, Andreas; Ofner, Patrick; Pereira, Joana; Ioana Sburlea, Andreea; Müller-Putz, Gernot R.

    2018-02-01

    Objective. Despite the high number of degrees of freedom of the human hand, most actions of daily life can be executed incorporating only palmar, pincer and lateral grasp. In this study we attempt to discriminate these three different executed reach-and-grasp actions utilizing their EEG neural correlates. Approach. In a cue-guided experiment, 15 healthy individuals were asked to perform these actions using daily life objects. We recorded 72 trials for each reach-and-grasp condition and from a no-movement condition. Main results. Using low-frequency time domain features from 0.3 to 3 Hz, we achieved binary classification accuracies of 72.4%, STD  ±  5.8% between grasp types, for grasps versus no-movement condition peak performances of 93.5%, STD  ±  4.6% could be reached. In an offline multiclass classification scenario which incorporated not only all reach-and-grasp actions but also the no-movement condition, the highest performance could be reached using a window of 1000 ms for feature extraction. Classification performance peaked at 65.9%, STD  ±  8.1%. Underlying neural correlates of the reach-and-grasp actions, investigated over the primary motor cortex, showed significant differences starting from approximately 800 ms to 1200 ms after the movement onset which is also the same time frame where classification performance reached its maximum. Significance. We could show that it is possible to discriminate three executed reach-and-grasp actions prominent in people’s everyday use from non-invasive EEG. Underlying neural correlates showed significant differences between all tested conditions. These findings will eventually contribute to our attempt of controlling a neuroprosthesis in a natural and intuitive way, which could ultimately benefit motor impaired end users in their daily life actions.

  14. Do working environment interventions reach shift workers?

    Science.gov (United States)

    Nabe-Nielsen, Kirsten; Jørgensen, Marie Birk; Garde, Anne Helene; Clausen, Thomas

    2016-01-01

    Shift workers are exposed to more physical and psychosocial stressors in the working environment as compared to day workers. Despite the need for targeted prevention, it is likely that workplace interventions less frequently reach shift workers. The aim was therefore to investigate whether the reach of workplace interventions varied between shift workers and day workers and whether such differences could be explained by the quality of leadership exhibited at different times of the day. We used questionnaire data from 5361 female care workers in the Danish eldercare sector. The questions concerned usual working hours, quality of leadership, and self-reported implementation of workplace activities aimed at stress reduction, reorganization of the working hours, and participation in improvements of working procedures or qualifications. Compared with day workers, shift workers were less likely to be reached by workplace interventions. For example, night workers less frequently reported that they had got more flexibility (OR 0.5; 95 % CI 0.3-0.7) or that they had participated in improvements of the working procedures (OR 0.6; 95 % CI 0.5-0.8). Quality of leadership to some extent explained the lack of reach of interventions especially among fixed evening workers. In the light of the evidence of shift workers' stressful working conditions, we suggest that future studies focus on the generalizability of results of the present study and on how to reach this group and meet their needs when designing and implementing workplace interventions.

  15. 850-nm Zn-diffusion vertical-cavity surface-emitting lasers with with oxide-relief structure for high-speed and energy-efficient optical interconnects from very-short to medium (2km) reaches

    Science.gov (United States)

    Shi, Jin-Wei; Wei, Chia-Chien; Chen, Jason (Jyehong); Yang, Ying-Jay

    2015-03-01

    High-speed and "green" ~850 nm vertical-cavity surface-emitting lasers (VCSELs) have lately attracted lots of attention due to their suitability for applications in optical interconnects (OIs). To further enhance the speed and its maximum allowable linking distance of VCSELs are two major trends to meet the requirement of OI in next generation data centers. Recently, by use of the advanced 850 nm VCSEL technique, data rate as high as 64 Gbit/sec over 57m and 20 Gbit/sec over 2km MMF transmission have been demonstrated, respectively. Here, we will review our recent work about 850 nm Zn-diffusion VCSELs with oxide-relief apertures to further enhance the above-mentioned performances. By using Zn-diffusion, we can not only reduce the device resistance but also manipulate the number of optical modes to benefit transmission. Combing such device, which has excellent single-mode (SMSR >30 dB) and high-power (~7mW) performance, with advanced modulation format (OFDM), record-high bit-rate-distance-product through MMF (2.3 km×28 Gbit/sec) has been demonstrated. Furthermore, by selective etching away the oxide aperture inside Zn-diffusion VCSEL, significant enhancement of device speed, D-factor, and reliability can be observed. With such unique VCSEL structure, >40 Gbit/sec energy-efficient transmission over 100m MMF under extremely low-driving current density (<10kA/cm2) has been successfully demonstrated.

  16. Guiding Warfare to Reach Sustainable Peace

    DEFF Research Database (Denmark)

    Vestenskov, David; Drewes, Line

    The conference report Guiding Warfare to Reach Sustainable Peace constitutes the primary outcome of the conference It is based on excerpts from the conference presenters and workshop discussions. Furthermore, the report contains policy recommendations and key findings, with the ambition of develo......The conference report Guiding Warfare to Reach Sustainable Peace constitutes the primary outcome of the conference It is based on excerpts from the conference presenters and workshop discussions. Furthermore, the report contains policy recommendations and key findings, with the ambition...... of developing best practices in the education and implementation of IHL in capacity building of security forces....

  17. Do working environment interventions reach shift workers?

    DEFF Research Database (Denmark)

    Nabe-Nielsen, Kirsten; Jørgensen, Marie Birk; Garde, Anne Helene

    2016-01-01

    PURPOSE: Shift workers are exposed to more physical and psychosocial stressors in the working environment as compared to day workers. Despite the need for targeted prevention, it is likely that workplace interventions less frequently reach shift workers. The aim was therefore to investigate whether...... the reach of workplace interventions varied between shift workers and day workers and whether such differences could be explained by the quality of leadership exhibited at different times of the day. METHODS: We used questionnaire data from 5361 female care workers in the Danish eldercare sector...

  18. Sufficiency and Duality for Multiobjective Programming under New Invexity

    Directory of Open Access Journals (Sweden)

    Yingchun Zheng

    2016-01-01

    Full Text Available A class of multiobjective programming problems including inequality constraints is considered. To this aim, some new concepts of generalized F,P-type I and F,P-type II functions are introduced in the differentiable assumption by using the sublinear function F. These new functions are used to establish and prove the sufficient optimality conditions for weak efficiency or efficiency of the multiobjective programming problems. Moreover, two kinds of dual models are formulated. The weak dual, strong dual, and strict converse dual results are obtained under the aforesaid functions.

  19. On the Necessary and Sufficient Assumptions for UC Computation

    DEFF Research Database (Denmark)

    Damgård, Ivan Bjerre; Nielsen, Jesper Buus; Orlandi, Claudio

    2010-01-01

    for all of them. Perhaps most interestingly we show that: •  For even the minimal meaningful KRA, where we only assume that the secret key is a value which is hard to compute from the public key, one can UC securely compute any poly-time functionality if there exists a passive secure oblivious...... that in the KRA model one-way functions are sufficient for UC commitment and UC zero-knowledge. These are the first examples of UC secure protocols for non-trivial tasks which do not assume the existence of public-key primitives. In particular, the protocols show that non-trivial UC computation is possible...

  20. Pathogens in Sludge: A Case of Sufficient Challenge

    Energy Technology Data Exchange (ETDEWEB)

    Lesilind, R. Aarne

    2003-07-01

    There is increasing pressure in many countries to strengthen the regulations controlling the land disposal of wastewater sludges. In this paper I argue that although there is little doubt that sludges from wastewater treatment contain pathogenic organisms, not only are there no data to show that such disposal is a public health problem, but I want to suggest that small doses of pathogens in the environment provide a ''sufficient challenge'' that actually enhances public health. There therefore seems little reason, from a public health standpoint, to pass stricter sludge disposal regulations. (author)

  1. LDR: A Package for Likelihood-Based Sufficient Dimension Reduction

    Directory of Open Access Journals (Sweden)

    R. Dennis Cook

    2011-03-01

    Full Text Available We introduce a new mlab software package that implements several recently proposed likelihood-based methods for sufficient dimension reduction. Current capabilities include estimation of reduced subspaces with a fixed dimension d, as well as estimation of d by use of likelihood-ratio testing, permutation testing and information criteria. The methods are suitable for preprocessing data for both regression and classification. Implementations of related estimators are also available. Although the software is more oriented to command-line operation, a graphical user interface is also provided for prototype computations.

  2. CANDU: Meeting the demand for energy self-sufficiency

    International Nuclear Information System (INIS)

    Lawson, D.S.

    1985-01-01

    The success of the CANDU program can been seen quickly by examining the comparison of typical electricity bills in various provinces of Canada. The provinces of Quebec and Manitoba benefit b extensive hydro electric schemes, many of which were constructed years ago at low capital cost. In Ontario, the economic growth has outstripped these low cost sources of hydro power and hence the province has to rely on thermal sources of electricity generation. The success of the CANDU program is shown by the fact that it can contribute over a third of electricity in Ontario while keeping the total electricity rate comparable with that of those provinces that can rely on low cost hydro sources. Energy self-sufficiency encompasses a spectrum of requirements. One consideration would be the reliable supply and control of fuel during the operating life of a power plant: A greater degree of self-sufficiency would be obtained by having an involvement in the building and engineering of the power plant prior to its operation

  3. Sufficient and necessary condition of separability for generalized Werner states

    International Nuclear Information System (INIS)

    Deng Dongling; Chen Jingling

    2009-01-01

    In a celebrated paper [Optics Communications 179, 447, 2000], A.O. Pittenger and M.H. Rubin presented for the first time a sufficient and necessary condition of separability for the generalized Werner states. Inspired by their ideas, we generalized their method to a more general case. We obtain a sufficient and necessary condition for the separability of a specific class of N d-dimensional system (qudits) states, namely special generalized Werner state (SGWS): W [d N ] (v)=(1-v)(I (N) )/(d N ) +v|ψ d N > d N |, where |ψ d N >=Σ i=0 d-1 α i |i...i> is an entangled pure state of N qudits system and α i satisfies two restrictions: (i) Σ i=0 d-1 α i α i *=1; (ii) Matrix 1/d (I (1) +TΣ i≠j α i |i> j *), where T=Min i≠j {1/|α i α j |}, is a density matrix. Our condition gives quite a simple and efficiently computable way to judge whether a given SGWS is separable or not and previously known separable conditions are shown to be special cases of our approach

  4. Vaccine procurement and self-sufficiency in developing countries.

    Science.gov (United States)

    Woodle, D

    2000-06-01

    This paper discusses the movement toward self-sufficiency in vaccine supply in developing countries (and countries in transition to new economic and political systems) and explains special supply concerns about vaccine as a product class. It traces some history of donor support and programmes aimed at self-financing, then continues with a discussion about self-sufficiency in terms of institutional capacity building. A number of deficiencies commonly found in vaccine procurement and supply in low- and middle-income countries are characterized, and institutional strengthening with procurement technical assistance is described. The paper also provides information about a vaccine procurement manual being developed by the United States Agency for International Development (USAID) and the World Health Organization (WHO) for use in this environment. Two brief case studies are included to illustrate the spectrum of existing capabilities and different approaches to technical assistance aimed at developing or improving vaccine procurement capability. In conclusion, the paper discusses the special nature of vaccine and issues surrounding potential integration and decentralization of vaccine supply systems as part of health sector reform.

  5. Revenue Sufficiency and Reliability in a Zero Marginal Cost Future

    Energy Technology Data Exchange (ETDEWEB)

    Frew, Bethany A.

    2017-04-17

    Features of existing wholesale electricity markets, such as administrative pricing rules and policy-based reliability standards, can distort market incentives from allowing generators sufficient opportunities to recover both fixed and variable costs. Moreover, these challenges can be amplified by other factors, including (1) inelastic demand resulting from a lack of price signal clarity, (2) low- or near-zero marginal cost generation, particularly arising from low natural gas fuel prices and variable generation (VG), such as wind and solar, and (3) the variability and uncertainty of this VG. As power systems begin to incorporate higher shares of VG, many questions arise about the suitability of the existing marginal-cost-based price formation, primarily within an energy-only market structure, to ensure the economic viability of resources that might be needed to provide system reliability. This article discusses these questions and provides a summary of completed and ongoing modelling-based work at the National Renewable Energy Laboratory to better understand the impacts of evolving power systems on reliability and revenue sufficiency.

  6. The Lung Screen Uptake Trial (LSUT): protocol for a randomised controlled demonstration lung cancer screening pilot testing a targeted invitation strategy for high risk and 'hard-to-reach' patients.

    Science.gov (United States)

    Quaife, Samantha L; Ruparel, Mamta; Beeken, Rebecca J; McEwen, Andy; Isitt, John; Nolan, Gary; Sennett, Karen; Baldwin, David R; Duffy, Stephen W; Janes, Samuel M; Wardle, Jane

    2016-04-20

    Participation in low-dose CT (LDCT) lung cancer screening offered in the trial context has been poor, especially among smokers from socioeconomically deprived backgrounds; a group for whom the risk-benefit ratio is improved due to their high risk of lung cancer. Attracting high risk participants is essential to the success and equity of any future screening programme. This study will investigate whether the observed low and biased uptake of screening can be improved using a targeted invitation strategy. A randomised controlled trial design will be used to test whether targeted invitation materials are effective at improving engagement with an offer of lung cancer screening for high risk candidates. Two thousand patients aged 60-75 and recorded as a smoker within the last five years by their GP, will be identified from primary care records and individually randomised to receive either intervention invitation materials (which take a targeted, stepped and low burden approach to information provision prior to the appointment) or control invitation materials. The primary outcome is uptake of a nurse-led 'lung health check' hospital appointment, during which patients will be offered a spirometry test, an exhaled carbon monoxide (CO) reading, and an LDCT if eligible. Initial data on demographics (i.e. age, sex, ethnicity, deprivation score) and smoking status will be collected in primary care and analysed to explore differences between attenders and non-attenders with respect to invitation group. Those who attend the lung health check will have further data on smoking collected during their appointment (including pack-year history, nicotine dependence and confidence to quit). Secondary outcomes will include willingness to be screened, uptake of LDCT and measures of informed decision-making to ensure the latter is not compromised by either invitation strategy. If effective at improving informed uptake of screening and reducing bias in participation, this invitation

  7. Reaching Reluctant Students: Insights from Torey Hayden.

    Science.gov (United States)

    Marlowe, Mike

    1999-01-01

    Illustrates principles of reaching students who fight or avoid adults by using examples drawn from the writings of Torey Hayden. Presents ten concepts that can serve as guidelines for building relationships with resistant children, and gives excerpts from Hayden's works to illustrate each concept. Demonstrates how books provide teachers with…

  8. ATLAS Barrel Toroid magnet reached nominal field

    CERN Multimedia

    2006-01-01

     On 9 November the barrel toroid magnet reached its nominal field of 4 teslas, with an electrical current of 21 000 amperes (21 kA) passing through the eight superconducting coils as shown on this graph

  9. Composite Coiled Tubing for Extended Reach in Horizontal Oil Wells

    DEFF Research Database (Denmark)

    Costache, Andrei; Berggreen, Christian

    2017-01-01

    Conventional steel coiled tubing cannot reach along the entire length of very long horizontal oil wells. A lighter and more buoyant coiled tube is made possible using composite materials. The high stiffness to weight ratio of fiber reinforced polymers, coupled with a lower coefficient of friction......, has the potential of greatly extending the reach in horizontal oil wells. This study shows how to design composite coiled tubing and gives a comprehensive discussion about the most influential parameters. Several solutions, using glass-fiber and carbon are considered. Finite element models are used...

  10. Nature exposure sufficiency and insufficiency: The benefits of environmental preservation.

    Science.gov (United States)

    Reddon, John R; Durante, Salvatore B

    2018-01-01

    Increasing industrialization, urbanization, and a failure of many world leaders to appreciate the consequences of climate change are deleteriously impacting quality of life as well as diminishing the prospects for long term survival. Economic competitiveness and corporate profitability often pre-empt environmental concerns. The calving of an iceberg in Antarctica and the hurricane activity in the Caribbean during 2017 are unfortunate illustrations of the continuing escalation of environmental issues. We provide historical and current evidence for the importance of Nature Exposure (NE) and introduce the continuum Nature Exposure Sufficiency (NES) and Insufficiency (NEI). Insufficiency includes impoverished environments (e.g., slums and prisons) where nature exposure is very limited. Nature Exposure Sufficiency (NES) is an optimal amount of exposure to nature where many benefits such as reinvigoration can be obtained by everyone. NES also has several benefits for individuals with various health conditions such as arthritis, dementia, or depression. The benefits of NE are not just derivable from parks, forests, and other natural settings. Interiors of buildings and homes can be enhanced with plants and even pictures or objects from nature. Additionally, there is abundant evidence indicating that virtual and artificial environments depicting nature can provide substantial NE and therefore contribute to general wellbeing. Besides the difficulty in achieving cooperation amongst nations, corporations, and other collectives in developing and implementing long range plans to deal with climate change, there is also sometimes an aversion at the individual level whereby people are unwilling to experience nature due to insects and other discomforts. Such individuals are often averse to supplanting the comforts of home, even temporarily, with inadequate facilities that are seemingly less pleasant than their typical dwellings. We propose using the term Nature Exposure Aversion

  11. Artificial Self-Sufficient P450 in Reversed Micelles

    Directory of Open Access Journals (Sweden)

    Teruyuki Nagamune

    2010-04-01

    Full Text Available Cytochrome P450s are heme-containing monooxygenases that require electron transfer proteins for their catalytic activities. They prefer hydrophobic compounds as substrates and it is, therefore, desirable to perform their reactions in non-aqueous media. Reversed micelles can stably encapsulate proteins in nano-scaled water pools in organic solvents. However, in the reversed micellar system, when multiple proteins are involved in a reaction they can be separated into different micelles and it is then difficult to transfer electrons between proteins. We show here that an artificial self-sufficient cytochrome P450, which is an enzymatically crosslinked fusion protein composed of P450 and electron transfer proteins, showed micelle-size dependent catalytic activity in a reversed micellar system. Furthermore, the presence of thermostable alcohol dehydrogenase promoted the P450-catalyzed reaction due to cofactor regeneration.

  12. Self-sufficiency of an autonomous reconfigurable modular robotic organism

    CERN Document Server

    Qadir, Raja Humza

    2015-01-01

    This book describes how the principle of self-sufficiency can be applied to a reconfigurable modular robotic organism. It shows the design considerations for a novel REPLICATOR robotic platform, both hardware and software, featuring the behavioral characteristics of social insect colonies. Following a comprehensive overview of some of the bio-inspired techniques already available, and of the state-of-the-art in re-configurable modular robotic systems, the book presents a novel power management system with fault-tolerant energy sharing, as well as its implementation in the REPLICATOR robotic modules. In addition, the book discusses, for the first time, the concept of “artificial energy homeostasis” in the context of a modular robotic organism, and shows its verification on a custom-designed simulation framework in different dynamic power distribution and fault tolerance scenarios. This book offers an ideal reference guide for both hardware engineers and software developers involved in the design and implem...

  13. Are emotions necessary and sufficient for making moral judgments?

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Sousa Alves

    2013-07-01

    Full Text Available http://dx.doi.org/10.5007/1677-2954.2013v12n1p113 Jesse Prinz (2006, 2007 claimed that emotions are necessary and sufficient for moral judgments. First of all, I clarify what this claim amounts to. The view that he labels emotionism will then be critically assessed. Prinz marshals empirical findings to defend a series of increasingly strong theses about how emotions are essential for moral judgments. I argue that the empirical support upon which his arguments are based is not only insufficient, but it even suggests otherwise, if properly interpreted. My criticism is then extended to his sentimentalist theory, that accounts for how emotions are integrated into moral judgments. The central problem is that Prinz’s view fails to capture the rational aspect of moral evaluation. I make this failure explicit and defend that some version or other of neosentimentalism is a more promising route.

  14. Inactivation of Parietal Reach Region Affects Reaching But Not Saccade Choices in Internally Guided Decisions.

    Science.gov (United States)

    Christopoulos, Vassilios N; Bonaiuto, James; Kagan, Igor; Andersen, Richard A

    2015-08-19

    The posterior parietal cortex (PPC) has traditionally been considered important for awareness, spatial perception, and attention. However, recent findings provide evidence that the PPC also encodes information important for making decisions. These findings have initiated a running argument of whether the PPC is critically involved in decision making. To examine this issue, we reversibly inactivated the parietal reach region (PRR), the area of the PPC that is specialized for reaching movements, while two monkeys performed a memory-guided reaching or saccade task. The task included choices between two equally rewarded targets presented simultaneously in opposite visual fields. Free-choice trials were interleaved with instructed trials, in which a single cue presented in the peripheral visual field defined the reach and saccade target unequivocally. We found that PRR inactivation led to a strong reduction of contralesional choices, but only for reaches. On the other hand, saccade choices were not affected by PRR inactivation. Importantly, reaching and saccade movements to single instructed targets remained largely intact. These results cannot be explained as an effector-nonspecific deficit in spatial attention or awareness, since the temporary "lesion" had an impact only on reach choices. Hence, the PPR is a part of a network for reach decisions and not just reach planning. There has been an ongoing debate on whether the posterior parietal cortex (PPC) represents only spatial awareness, perception, and attention or whether it is also involved in decision making for actions. In this study we explore whether the parietal reach region (PRR), the region of the PPC that is specialized for reaches, is involved in the decision process. We inactivated the PRR while two monkeys performed reach and saccade choices between two targets presented simultaneously in both hemifields. We found that inactivation affected only the reach choices, while leaving saccade choices intact

  15. Does workplace health promotion reach shift workers?

    DEFF Research Database (Denmark)

    Nabe-Nielsen, Kirsten; Garde, Anne Helene; Clausen, Thomas

    2015-01-01

    OBJECTIVES: One reason for health disparities between shift and day workers may be that workplace health promotion does not reach shift workers to the same extent as it reaches day workers. This study aimed to investigate the association between shift work and the availability of and participation...... in workplace health promotion. METHODS: We used cross-sectional questionnaire data from a large representative sample of all employed people in Denmark. We obtained information on the availability of and participation in six types of workplace health promotion. We also obtained information on working hours, ie......). RESULTS: In the general working population, fixed evening and fixed night workers, and employees working variable shifts including night work reported a higher availability of health promotion, while employees working variable shifts without night work reported a lower availability of health promotion...

  16. Olefins and chemical regulation in Europe: REACH.

    Science.gov (United States)

    Penman, Mike; Banton, Marcy; Erler, Steffen; Moore, Nigel; Semmler, Klaus

    2015-11-05

    REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) is the European Union's chemical regulation for the management of risk to human health and the environment (European Chemicals Agency, 2006). This regulation entered into force in June 2007 and required manufacturers and importers to register substances produced in annual quantities of 1000 tonnes or more by December 2010, with further deadlines for lower tonnages in 2013 and 2018. Depending on the type of registration, required information included the substance's identification, the hazards of the substance, the potential exposure arising from the manufacture or import, the identified uses of the substance, and the operational conditions and risk management measures applied or recommended to downstream users. Among the content developed to support this information were Derived No-Effect Levels or Derived Minimal Effect Levels (DNELs/DMELs) for human health hazard assessment, Predicted No Effect Concentrations (PNECs) for environmental hazard assessment, and exposure scenarios for exposure and risk assessment. Once registered, substances may undergo evaluation by the European Chemicals Agency (ECHA) or Member State authorities and be subject to requests for additional information or testing as well as additional risk reduction measures. To manage the REACH registration and related activities for the European olefins and aromatics industry, the Lower Olefins and Aromatics REACH Consortium was formed in 2008 with administrative and technical support provided by Penman Consulting. A total of 135 substances are managed by this group including 26 individual chemical registrations (e.g. benzene, 1,3-butadiene) and 13 categories consisting of 5-26 substances. This presentation will describe the content of selected registrations prepared for 2010 in addition to the significant post-2010 activities. Beyond REACH, content of the registrations may also be relevant to other European activities, for

  17. Economic efficiency or self-sufficiency: alternative strategies for oil consumers?

    International Nuclear Information System (INIS)

    Heal, D.W.

    1992-01-01

    The ideal energy source is low cost (efficient) and reliable (secure). The high price and perceived political unreliability of Middle East oil supplies prompted a nearly worldwide trend towards energy self-sufficiency. Gains in energy efficiency, which have been most marked in the OECD, are permanent and, prompted by environmental concern, probably progressive. But the opportunity that is still available to low cost oil suppliers to regain lost markets will only be realized if those supplies are demonstrably reliable. (author)

  18. India's baseline plan for nuclear energy self-sufficiency

    International Nuclear Information System (INIS)

    Bucher, R.G.

    2009-01-01

    India's nuclear energy strategy has traditionally strived for energy self-sufficiency, driven largely by necessity following trade restrictions imposed by the Nuclear Suppliers Group (NSG) following India's 'peaceful nuclear explosion' of 1974. On September 6, 2008, the NSG agreed to create an exception opening nuclear trade with India, which may create opportunities for India to modify its baseline strategy. The purpose of this document is to describe India's 'baseline plan,' which was developed under constrained trade conditions, as a basis for understanding changes in India's path as a result of the opening of nuclear commerce. Note that this treatise is based upon publicly available information. No attempt is made to judge whether India can meet specified goals either in scope or schedule. In fact, the reader is warned a priori that India's delivery of stated goals has often fallen short or taken a significantly longer period to accomplish. It has been evident since the early days of nuclear power that India's natural resources would determine the direction of its civil nuclear power program. It's modest uranium but vast thorium reserves dictated that the country's primary objective would be thorium utilization. Estimates of India's natural deposits vary appreciably, but its uranium reserves are known to be extremely limited, totaling approximately 80,000 tons, on the order of 1% of the world's deposits; and nominally one-third of this ore is of very low uranium concentration. However, India's roughly 300,000 tons of thorium reserves account for approximately 30% of the world's total. Confronted with this reality, the future of India's nuclear power industry is strongly dependent on the development of a thorium-based nuclear fuel cycle as the only way to insure a stable, sustainable, and autonomous program. The path to India's nuclear energy self-sufficiency was first outlined in a seminal paper by Drs. H. J. Bhabha and N. B. Prasad presented at the Second

  19. REACHING ULTRA HIGH PEAK CHARACTERISTICS IN RELATIVISTIC THOMSON BACKSCATTERING

    International Nuclear Information System (INIS)

    POGORELSKY, I.V.; BEN ZVI, I.; HIROSE, T.; KASHIWAGI, S.; YAKIMENKO, V.; KUSCHE, K.; SIDDONS, P.; ET AL

    2001-01-01

    The concept of x-ray laser synchrotron sources (LSS) based on Thomson scattering between laser photons and relativistic electrons leads to future femtosecond light-source facilities fit to multidisciplinary research in ultra-fast structural dynamics. Enticed by these prospects, the Brookhaven Accelerator Test Facility (ATF) embarked into development of the LSS based on a combination of a photocathode RF linac and a picosecond CO 2 laser. We observed the record 1.7 x 10 8 x-ray photons/pulse yield generated via relativistic Thomson scattering between the 14 GW CO 2 laser and 60 MeV electron beam

  20. On necessity and sufficiency in counseling and psychotherapy (revisited).

    Science.gov (United States)

    Lazarus, Arnold A

    2007-09-01

    It seems to me that Carl Rogers (see record 2007-14639-002) was far too ambitious in trying to specify general conditions of necessity and sufficiency that would be relevant to the entire spectrum of problems and the diverse expectancies and personalities of the people who seek our help. Rogers' position and orientation almost totally overlook the array of problems under the rubric of "response deficits" that stem from misinformation and missing information and call for active correction, training, and retraining. Rogers also paid scant attention to problems with significant biological determinants. Nevertheless, as exemplified by his seminal 1957 article and many other articles and books, Rogers made major contributions within the domain of the therapeutic alliance. Today, the scientific emphasis looks at accountability, the need to establish various treatments of choice, and the need to understand their presumed mechanisms. Treatment efficacy and generalizability across different methodologies are now considered key issues. The efficacy narrowing and clinically self-limiting consequences of adhering to one particular school of thought are now self-evident to most. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  1. Arterial stiffening provides sufficient explanation for primary hypertension.

    Directory of Open Access Journals (Sweden)

    Klas H Pettersen

    2014-05-01

    Full Text Available Hypertension is one of the most common age-related chronic disorders, and by predisposing individuals for heart failure, stroke, and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and mechanics of the circulatory system, we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emergence of hypertension. Specifically, the empirically observed chronic changes in pulse pressure with age and the impaired capacity of hypertensive individuals to regulate short-term changes in blood pressure arise as emergent properties of the integrated system. The results are consistent with available experimental data from chemical and surgical manipulation of the cardio-vascular system. In contrast to widely held opinions, the results suggest that primary hypertension can be attributed to a mechanogenic etiology without challenging current conceptions of renal and sympathetic nervous system function.

  2. Powerful Statistical Inference for Nested Data Using Sufficient Summary Statistics

    Science.gov (United States)

    Dowding, Irene; Haufe, Stefan

    2018-01-01

    Hierarchically-organized data arise naturally in many psychology and neuroscience studies. As the standard assumption of independent and identically distributed samples does not hold for such data, two important problems are to accurately estimate group-level effect sizes, and to obtain powerful statistical tests against group-level null hypotheses. A common approach is to summarize subject-level data by a single quantity per subject, which is often the mean or the difference between class means, and treat these as samples in a group-level t-test. This “naive” approach is, however, suboptimal in terms of statistical power, as it ignores information about the intra-subject variance. To address this issue, we review several approaches to deal with nested data, with a focus on methods that are easy to implement. With what we call the sufficient-summary-statistic approach, we highlight a computationally efficient technique that can improve statistical power by taking into account within-subject variances, and we provide step-by-step instructions on how to apply this approach to a number of frequently-used measures of effect size. The properties of the reviewed approaches and the potential benefits over a group-level t-test are quantitatively assessed on simulated data and demonstrated on EEG data from a simulated-driving experiment. PMID:29615885

  3. Syndesmotic Malreduction after Ankle ORIF; Is Radiography Sufficient?

    Directory of Open Access Journals (Sweden)

    Alireza Manafi Rasi

    2013-12-01

    Full Text Available   Background: Ankle fractures, especially those resulting from external rotation mechanisms are associated with injury to the distal tibiofibular syndesmosis. Some authors have recommended performing CT scanning after open ankle surgery to evaluate the reduction of syndesmosis. In this current study, we aimed to investigate the sensitivity of plain radiography in diagnosing syndesmosis malreduction after open reduction and internal fixation (ORIF in patients with ankle fractures.   Methods: Thirty patients with ankle fractures participated in this prospective study. ORIFs were performed with respect to all of the technical guidelines shown in orthopedic literature for exact syndesmosis reduction, such as fibular length and proper settings. In the operating room, plain radiography was performed in anteroposterior, mortise and lateral views to assess whether syndesmosis was malreduced. If malreduction was detected, the patient was revised. As the gold standard, patients underwent postoperative bilateral CT scanning to investigate the syndesmosis reduction which was then compared to the healthy side. Finally, the sensitivity of plain radiography in the diagnosis of syndesmosis malreduction was determined by comparing this method to CT scanning. Results: In both of the methods we did not find any patient with syndesmosis malreduction. Hence, the sensitivity of plain radiography was determined 100%. Conclusion: Based on our findings, there is no need to perform CT scanning to evaluate syndesmosis reduction after ankle ORIF in patients with ankle fractures. Plain radiography is sufficient and has satisfactory sensitivity in these patients.

  4. Syndesmotic Malreduction after Ankle ORIF; Is Radiography Sufficient?

    Directory of Open Access Journals (Sweden)

    Alireza Manafi Rasi

    2013-12-01

    Full Text Available Background: Ankle fractures, especially those resulting from external rotation mechanisms are associated with injury to the distal tibiofibular syndesmosis. Some authors have recommended performing CT scanning after open ankle surgery to evaluate the reduction of syndesmosis. In this current study, we aimed to investigate the sensitivity of plain radiography in diagnosing syndesmosis malreduction after open reduction and internal fixation (ORIF in patients with ankle fractures.   Methods: Thirty patients with ankle fractures participated in this prospective study. ORIFs were performed with respect to all of the technical guidelines shown in orthopedic literature for exact syndesmosis reduction, such as fibular length and proper settings. In the operating room, plain radiography was performed in anteroposterior, mortise and lateral views to assess whether syndesmosis was malreduced. If malreduction was detected, the patient was revised. As the gold standard, patients underwent postoperative bilateral CT scanning to investigate the syndesmosis reduction which was then compared to the healthy side. Finally, the sensitivity of plain radiography in the diagnosis of syndesmosis malreduction was determined by comparing this method to CT scanning. Results: In both of the methods we did not find any patient with syndesmosis malreduction. Hence, the sensitivity of plain radiography was determined 100%. Conclusion: Based on our findings, there is no need to perform CT scanning to evaluate syndesmosis reduction after ankle ORIF in patients with ankle fractures. Plain radiography is sufficient and has satisfactory sensitivity in these patients.

  5. Riparian Vegetation Mapping Along the Hanford Reach

    International Nuclear Information System (INIS)

    FOGWELL, T.W.

    2003-01-01

    During the biological survey and inventory of the Hanford Site conducted in the mid-1990s (1995 and 1996), preliminary surveys of the riparian vegetation were conducted along the Hanford Reach. These preliminary data were reported to The Nature Conservancy (TNC), but were not included in any TNC reports to DOE or stakeholders. During the latter part of FY2001, PNNL contracted with SEE Botanical, the parties that performed the original surveys in the mid 1990s, to complete the data summaries and mapping associated with the earlier survey data. Those data sets were delivered to PNNL and the riparian mapping by vegetation type for the Hanford Reach is being digitized during the first quarter of FY2002. These mapping efforts provide the information necessary to create subsequent spatial data layers to describe the riparian zone according to plant functional types (trees, shrubs, grasses, sedges, forbs). Quantification of the riparian zone by vegetation types is important to a number of DOE'S priority issues including modeling contaminant transport and uptake in the near-riverine environment and the determination of ecological risk. This work included the identification of vegetative zones along the Reach by changes in dominant plant species covering the shoreline from just to the north of the 300 Area to China Bar near Vernita. Dominant and indicator species included Agropyron dasytachyudA. smithii, Apocynum cannabinum, Aristida longiseta, Artemisia campestris ssp. borealis var scouleriana, Artemisa dracunculus, Artemisia lindleyana, Artemisia tridentata, Bromus tectorum, Chrysothamnus nauseosus, Coreopsis atkinsoniana. Eleocharis palustris, Elymus cinereus, Equisetum hyemale, Eriogonum compositum, Juniperus trichocarpa, Phalaris arundinacea, Poa compressa. Salk exigua, Scirpus acutus, Solidago occidentalis, Sporobolus asper,and Sporobolus cryptandrus. This letter report documents the data received, the processing by PNNL staff, and additional data gathered in FY2002

  6. Long-reach manipulators for decommissioning

    International Nuclear Information System (INIS)

    Webster, D.A.; Challinor, S.F.

    1993-01-01

    A survey of redundant facilities at Sellafield has identified that in many cases the conventional means of deploying remote handling equipment are not appropriate and that novel means must be employed. However, decommissioning is not a value adding activity and so expensive one off designs must be avoided. The paper will describe BNFL's approach to the synthesis from proprietary parts of a manipulator which can lift 3 te at a horizontal reach of over 5 metres and yet can still perform the dextrous manipulation necessary to remove small items. It will also cover the development of the manipulator control systems and the adaption of commercial handtools to be manipulator friendly. (author)

  7. Luminosity performance reach after LS1

    International Nuclear Information System (INIS)

    Herr, W.

    2012-01-01

    Based on past experience (2010/2011), in particular expected limitations from beam-beam effects, and taking into account the expected beam quality from the LHC injectors, the peak and integrated luminosity at top energy is discussed for different scenarios (e.g. bunch spacing, beta*). In particular it will be shown which are the key parameters to reach the nominal luminosity and it is also shown that peak luminosities two times larger than nominal (or higher) are possible. Possible test in 2012 are discussed

  8. City Reach Code Technical Support Document

    Energy Technology Data Exchange (ETDEWEB)

    Athalye, Rahul A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chen, Yan [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhang, Jian [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Liu, Bing [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Frankel, Mark [New Buildings Inst., Portland, OR (United States); Lyles, Mark [New Buildings Inst., Portland, OR (United States)

    2017-10-31

    This report describes and analyzes a set of energy efficiency measures that will save 20% energy over ASHRAE Standard 90.1-2013. The measures will be used to formulate a Reach Code for cities aiming to go beyond national model energy codes. A coalition of U.S. cities together with other stakeholders wanted to facilitate the development of voluntary guidelines and standards that can be implemented in stages at the city level to improve building energy efficiency. The coalition's efforts are being supported by the U.S. Department of Energy via Pacific Northwest National Laboratory (PNNL) and in collaboration with the New Buildings Institute.

  9. Amplified Erosion above Waterfalls and Oversteepened Bedrock Reaches

    Science.gov (United States)

    Haviv, I.; Enzel, Y.; Whipple, K. X.; Zilberman, E.; Stone, J.; Matmon, A.; Fifield, K. L.

    2005-12-01

    Although waterfalls are abundant along steep bedrock channels, none of the conventional erosion laws can predict incision at the lip of a waterfall where flow is non-uniform and bed slope can be vertical. Considering the expected increase in flow velocity and shear stress at the lip of a vertical waterfall we determine erosion amplification at a waterfall lip as: Elip/Enormal= (1+0.4/Fr2)3n, where Fr is the Froude number and n ranges between 0.5-1.7. This amplification expression suggests that erosion at the lip could be as much as 2-5 times higher than normally expected in a setting with identical hydraulic geometry. It also demonstrates that a freefall is expected to amplify upstream incision rates even when the flow approaching the waterfall is highly supercritical. Utilizing this erosion amplification expression in numerical simulations in conjunction with a standard detachment-limited incision model we demonstrate its impact on reach-scale morphology above waterfalls. These simulations indicate that amplified erosion at the lip of a waterfall can trigger the formation of an oversteepened reach whose length is longer than the flow acceleration zone, provided incision velocity (Vi) at the edge of the flow acceleration zone is higher than the retreat velocity of the waterfall face. Such an oversteepened reach is expected to be more pronounced when Vi increases with increasing slope. The simulations also suggest that oversteepening can eventually lead to quasi steady-state gradients upstream from a waterfall provided Vi decreases with increasing slope. Flow acceleration above waterfalls can thus account, at least partially, for oversteepened bedrock reaches that are prevalent above waterfalls. Such reaches have been reported for the escarpments of southeast Australia, western Dead Sea, and at Niagara Falls. Using the cosmogenic isotope 36Cl we demonstrate that Vi upstream of a waterfall at the Dead Sea western escarpment is high enough for freefall

  10. The effect of formal training of cardiopulmonary resuscitation (CPR skills on medical students perceived self-sufficiency

    Directory of Open Access Journals (Sweden)

    Shaghaghi A

    2004-07-01

    Full Text Available Background: Experience of cardiopulmonary resuscitation (CPR in real clinical setting is not easily possible for all medical students. Purpose: To assess medical student perceived self-sufficiency on three procedural skill on internship courses after they had taken a training course in clerkship period. Methods: Forty three medical students who had attended a workshop on CPR, tracheal intubations and venopuncture answered the questionnaires on their perceived self-sufficiency in performing these procedures after serving a few months as interns. Results: The mean score for perceived self-sufficiency (PSS was 75.84 (±18.63.Thre were a high correlation between the score given for the applicability of training in real life situation and the stress reduction scores on first time performing the procedure. Conclusion: The high degree of correlation between PSS scores and applicability scores, may warrant the consideration of new methods in procedural skills. Keywords: SKILL TRAINING, CPR TRAINING, PERCEIVED SELF-SUFFICIENCY

  11. Seasonal variations in composite riverbank stability in the Lower Jingjiang Reach, China

    Science.gov (United States)

    Xia, Junqiang; Zong, Quanli; Deng, Shanshan; Xu, Quanxi; Lu, Jinyou

    2014-11-01

    Bank erosion is a key process in a fluvial system in the context of river dynamics and geomorphology. Since the operation of the Three Gorges Project (TGP), the Lower Jingjiang Reach (LJR) below the dam has experienced continuous channel degradation, with the phenomenon of bank erosion occurring frequently in local reaches. Therefore it is necessary to quantitatively investigate seasonal variations in the stability of composite riverbanks along the reach in order to better understand the fluvial processes in the reach. Laboratory tests were conducted for the sampled soils at six riverbanks during a field survey, with various bank soil properties being presented for the first time. These test results show that: the cohesive bank soils are relatively loose due to the high water contents of 28.5-40.0% and the low dry densities of 1.31-1.47 tonnes/m3; and the cohesion or angle of internal friction generally decreases with an increase in water content of the cohesive soil. Based on the measured cross-sectional profiles and interpolated hydrological data, the near-bank hydrodynamic conditions and soil parameters of two typical composite riverbanks were then determined during the 2007 hydrological year. An improved method was proposed for calculating the stability at the mode of cantilever failure for the overhanging block of a composite riverbank, and the stability degrees of these two riverbanks were calculated at different stages. These results reveal that: (i) the incipient velocity of the non-cohesive lower bank had a magnitude of 0.4 m/s, less than the mean near-bank velocity of about 1.0 m/s, which led to intensive basal erosion especially during the flood season; (ii) the cohesive upper bank before failure had sufficient strength to resist direct fluvial erosion, but the failed soil mass deposited in the near-bank zone was disintegrated easily with the submerged immersion and was then transported downstream by fluvial entrainment; (iii) the degree of bank

  12. Efficacy of REACH Forgiveness across cultures.

    Science.gov (United States)

    Lin, Yin; Worthington, Everett L; Griffin, Brandon J; Greer, Chelsea L; Opare-Henaku, Annabella; Lavelock, Caroline R; Hook, Joshua N; Ho, Man Yee; Muller, Holly

    2014-09-01

    This study investigates the efficacy of the 6-hour REACH Forgiveness intervention among culturally diverse undergraduates. Female undergraduates (N = 102) and foreign extraction (46.2%) and domestic (43.8%) students in the United States were randomly assigned to immediate treatment or waitlist conditions. Treatment efficacy and the effect of culture on treatment response were assessed using measures of emotional and decisional forgiveness across 3 time periods. Students in the treatment condition reported greater improvement in emotional forgiveness, but not decisional forgiveness, relative to those in the waitlist condition. Gains were maintained at a 1-week follow-up. Although culture did not moderate the effect of treatment, a main effect of culture on emotional forgiveness and marginally significant interaction effect of culture on decisional forgiveness were found. The REACH Forgiveness intervention was efficacious for college students from different cultural backgrounds when conducted in the United States. However, some evidence may warrant development of culturally adapted forgiveness interventions. © 2014 Wiley Periodicals, Inc.

  13. National Energy Plan 1997 - 2010; Sustainable Energy self-sufficiency

    International Nuclear Information System (INIS)

    1997-01-01

    The present revision of the PEN consists of two parts, a diagnosis and a strategy. In the diagnosis; the evolution and the changes are analyzed foreseen in the international and national environments to establish the form like the energy sector is affected and it responds to these conditions. In second part it revises the strategy to incorporate the required adjustments of agreement with the changes in the environment, the demand perspectives and sector and national politics limits. In the international thing, the process of transformation of the system economic World cup will contribute to strengthen the liberalization actions, deregulation and privatization of the economies of the development countries. Great part of the dynamics growth, will be sustained then in the private investment and in an atmosphere of global competition. The formation of regional blocks opens favorable perspectives for new cooperation forms and development of resources. In the case of the American hemisphere and with reference to the energy sector, one has an important potential to improve the self-sufficiency starting from regional supplies, especially starting from fossil resources. This expectation is important for Colombia that has well-known reservations and important potentials in these resources. The tendencies waited in the fossil resources are more favorable for the countries than they can have reservations and growing production of petroleum and of natural gas. Nevertheless, the development of the coal maintains favorable expectations, but with important requirements as for efficiency and quality in the production that it guarantee the positioning in a more and more concerned market. In the environmental thing, the growth foreseen in the consumption of fossil fuels also bears to the increment in the 2010 in the greenhouse gases, at levels between 36% and 49% superiors to those of 1990. That most of this increment will originate in the in the development countries and

  14. Greater learnability is not sufficient to produce cultural universals.

    Science.gov (United States)

    Rafferty, Anna N; Griffiths, Thomas L; Ettlinger, Marc

    2013-10-01

    Looking across human societies reveals regularities in the languages that people speak and the concepts that they use. One explanation that has been proposed for these "cultural universals" is differences in the ease with which people learn particular languages and concepts. A difference in learnability means that languages and concepts possessing a particular property are more likely to be accurately transmitted from one generation of learners to the next. Intuitively, this difference could allow languages and concepts that are more learnable to become more prevalent after multiple generations of cultural transmission. If this is the case, the prevalence of languages and concepts with particular properties can be explained simply by demonstrating empirically that they are more learnable. We evaluate this argument using mathematical analysis and behavioral experiments. Specifically, we provide two counter-examples that show how greater learnability need not result in a property becoming prevalent. First, more learnable languages and concepts can nonetheless be less likely to be produced spontaneously as a result of transmission failures. We simulated cultural transmission in the laboratory to show that this can occur for memory of distinctive items: these items are more likely to be remembered, but not generated spontaneously once they have been forgotten. Second, when there are many languages or concepts that lack the more learnable property, sheer numbers can swamp the benefit produced by greater learnability. We demonstrate this using a second series of experiments involving artificial language learning. Both of these counter-examples show that simply finding a learnability bias experimentally is not sufficient to explain why a particular property is prevalent in the languages or concepts used in human societies: explanations for cultural universals based on cultural transmission need to consider the full set of hypotheses a learner could entertain and all of

  15. [Effect of vitamin sufficiency on adaptation syndrome in growing rats].

    Science.gov (United States)

    Sidorova, Iu S; Beketova, N A; Vrzhesinskaia, O A; Kodentsova, V M; Kosheleva, O V; Zorin, S N; Selifanov, A V; Mazo, V K

    2014-01-01

    The influence of vitamin supply of growing male -Wistar rats (n=21) with an initial body weight 53,5±0,9 g on their resistance to a single distress induced by the electric shock has been investigated. Control rats within 21 days received a complete semisynthetic diet,providingadequate amounts of vitamins. Combined vitamin deficiency in experimental rats was caused by 5-fold decrease of vitamin mixture amount in the feed and the total vitamin E exclusion from the mixture. On the 21st day, one day before the end of the experiment, both groups of rats were subjected to stress impact (electrocutaneous irritation on paws, 0,4 mA for 8 sec) and then animals were placed in metabolic cages to collect urine. By the end of the experiment, the animals with the combined vitamin deficiency lag behind in growth. Vitamin B2, A, B1 and E liver content decreased in experimental rats by 1,6, 2,3, 4,4 and 15 fold accordingly. Retinol plasma concentration was significantly reduced by 18%, α-tocopherol level - by 5 fold, urinary excretionof riboflavin and 4-pyridoxic acid (vitamin B6 metabolite) was significantly reduced by 6,5 and 2,46 times accordingly. MDA blood plasma concentration and the urinary ratio of oxidized and not oxidized form of 8-hydroxy-2'-deoxy-guanosine did not differ in both groups of rats. Urinary excretion of stress biomarker corticosterone in rats with combined vitamin deficit was 2,5-fold higher than in control rats. Thus, reducing of vitamins supply resulted in an increase of urine corticosterone in stressed rats, that characterized the intensity of general adaptation syndrome. This fact shows the importance of optimal sufficiency with vitamins in nonspecific (general) resistance to stress.

  16. CaFe2O4 as a self-sufficient solar energy converter

    Science.gov (United States)

    Tablero, C.

    2017-10-01

    An ideal solar energy to electricity or fuel converter should work without the use of any external bias potential. An analysis of self-sufficiency when CaFe2O4 is used to absorb the sunlight is carried out based on the CaFe2O4 absorption coefficient. We started to obtain this coefficient theoretically within the experimental bandgap range in order to fix the interval of possible values of photocurrents, maximum absorption efficiencies, and photovoltages and thus that of self-sufficiency considering only the radiative processes. Also for single-gap CaFe2O4, we evaluate an alternative for increasing the photocurrent and maximum absorption efficiency based on inserting an intermediate band using high doping or alloying.

  17. Riparian Vegetation Mapping Along the Hanford Reach

    Energy Technology Data Exchange (ETDEWEB)

    FOGWELL, T.W.

    2003-07-11

    During the biological survey and inventory of the Hanford Site conducted in the mid-1990s (1995 and 1996), preliminary surveys of the riparian vegetation were conducted along the Hanford Reach. These preliminary data were reported to The Nature Conservancy (TNC), but were not included in any TNC reports to DOE or stakeholders. During the latter part of FY2001, PNNL contracted with SEE Botanical, the parties that performed the original surveys in the mid 1990s, to complete the data summaries and mapping associated with the earlier survey data. Those data sets were delivered to PNNL and the riparian mapping by vegetation type for the Hanford Reach is being digitized during the first quarter of FY2002. These mapping efforts provide the information necessary to create subsequent spatial data layers to describe the riparian zone according to plant functional types (trees, shrubs, grasses, sedges, forbs). Quantification of the riparian zone by vegetation types is important to a number of DOE'S priority issues including modeling contaminant transport and uptake in the near-riverine environment and the determination of ecological risk. This work included the identification of vegetative zones along the Reach by changes in dominant plant species covering the shoreline from just to the north of the 300 Area to China Bar near Vernita. Dominant and indicator species included Agropyron dasytachyudA. smithii, Apocynum cannabinum, Aristida longiseta, Artemisia campestris ssp. borealis var scouleriana, Artemisa dracunculus, Artemisia lindleyana, Artemisia tridentata, Bromus tectorum, Chrysothamnus nauseosus, Coreopsis atkinsoniana. Eleocharis palustris, Elymus cinereus, Equisetum hyemale, Eriogonum compositum, Juniperus trichocarpa, Phalaris arundinacea, Poa compressa. Salk exigua, Scirpus acutus, Solidago occidentalis, Sporobolus asper,and Sporobolus cryptandrus. This letter report documents the data received, the processing by PNNL staff, and additional data gathered in FY

  18. Reach and get capability in a computing environment

    Science.gov (United States)

    Bouchard, Ann M [Albuquerque, NM; Osbourn, Gordon C [Albuquerque, NM

    2012-06-05

    A reach and get technique includes invoking a reach command from a reach location within a computing environment. A user can then navigate to an object within the computing environment and invoke a get command on the object. In response to invoking the get command, the computing environment is automatically navigated back to the reach location and the object copied into the reach location.

  19. Unified communication to reach vulnerable mothers.

    Science.gov (United States)

    Tezcan, B; Von Rege, I; Henkson, H; Oteng-Ntim, E

    2011-01-01

    The feasibility of using a mobile text to reach vulnerable patient groups was assessed in this study. A total of 121 pregnant or postnatal women were randomly asked to complete a questionnaire. The questionnaire was given to them in the antenatal clinic, postnatal ward, antenatal ward or in the day assessment unit at St Thomas' Hospital, London. The forms were collected and analysed using an Excel database. The results of this survey show that mobile technology is readily available for 97% of the obstetric population. In mothers from vulnerable groups and in mothers from deprived areas, 61% possessed 3rd generation mobile technology. The majority of mothers surveyed wanted their care supplemented by the use of their mobile phones.

  20. Validity of an Interactive Functional Reach Test.

    Science.gov (United States)

    Galen, Sujay S; Pardo, Vicky; Wyatt, Douglas; Diamond, Andrew; Brodith, Victor; Pavlov, Alex

    2015-08-01

    Videogaming platforms such as the Microsoft (Redmond, WA) Kinect(®) are increasingly being used in rehabilitation to improve balance performance and mobility. These gaming platforms do not have built-in clinical measures that offer clinically meaningful data. We have now developed software that will enable the Kinect sensor to assess a patient's balance using an interactive functional reach test (I-FRT). The aim of the study was to test the concurrent validity of the I-FRT and to establish the feasibility of implementing the I-FRT in a clinical setting. The concurrent validity of the I-FRT was tested among 20 healthy adults (mean age, 25.8±3.4 years; 14 women). The Functional Reach Test (FRT) was measured simultaneously by both the Kinect sensor using the I-FRT software and the Optotrak Certus(®) 3D motion-capture system (Northern Digital Inc., Waterloo, ON, Canada). The feasibility of implementing the I-FRT in a clinical setting was assessed by performing the I-FRT in 10 participants with mild balance impairments recruited from the outpatient physical therapy clinic (mean age, 55.8±13.5 years; four women) and obtaining their feedback using a NASA Task Load Index (NASA-TLX) questionnaire. There was moderate to good agreement between FRT measures made by the two measurement systems. The greatest agreement between the two measurement system was found with the Kinect sensor placed at a distance of 2.5 m [intraclass correlation coefficient (2,k)=0.786; PNASA/TLX questionnaire. FRT measures made using the Kinect sensor I-FRT software provides a valid clinical measure that can be used with the gaming platforms.

  1. Is the IAEA's Safeguard Strategic Plan Sufficient?

    International Nuclear Information System (INIS)

    Sokolski, H.; Gilinsky, V.

    2015-01-01

    IAEA safeguards have much improved and the Safeguards Department is commendably planning to further its technical capabilities and to make full use of its authority. Will this be enough to keep countries from exploiting nuclear power programmes to develop nuclear weapons, or to be in a position to do so rapidly should they so decide? Depending on nuclear programmes developments worldwide, especially on expansions in enrichment and reprocessing, and on how international affairs unfold, the answer may well be no. The fundamental limitations on the Department's ability to prevent proliferation are not technical, but conceptual. The Department is clearly motivated to carry out its technical activities competently. Yet it takes a relatively passive view of its role in the worldwide development of nuclear power-whatever technology comes into use, and whoever deploys it, the Department promises to exert its best effort to safeguard. In our view the Department should be more open about what it can or cannot realistically safeguard, and therefore what technology is permissible for deployment in national programmes. The Department's Strategic Plan says at the outset that its verifications assist the Agency to fulfil its statutory objective to ''accelerate and enlarge the contribution of atomic energy. . . '' The Department should judge itself by how well it promotes international security, not by its contribution to expanding nuclear power use. The Department's Vision includes advancing toward a nuclear weapons free world. That vision should include keeping states from deploying technologies that put them within easy reach of nuclear weapons. Our paper will suggest how the Department might supplement its current plan to best accomplish this. (author)

  2. Influence of Hydrogen-Based Storage Systems on Self-Consumption and Self-Sufficiency of Residential Photovoltaic Systems

    Directory of Open Access Journals (Sweden)

    Christian Pötzinger

    2015-08-01

    Full Text Available This paper analyzes the behavior of residential solar-powered electrical energy storage systems. For this purpose, a simulation model based on MATLAB/Simulink is developed. Investigating both short-time and seasonal hydrogen-based storage systems, simulations on the basis of real weather data are processed on a timescale of 15 min for a consideration period of 3 years. A sensitivity analysis is conducted in order to identify the most important system parameters concerning the proportion of consumption and the degree of self-sufficiency. Therefore, the influences of storage capacity and of storage efficiencies are discussed. A short-time storage system can increase the proportion of consumption by up to 35 percentage points compared to a self-consumption system without storage. However, the seasonal storing system uses almost the entire energy produced by the photovoltaic (PV system (nearly 100% self-consumption. Thereby, the energy drawn from the grid can be reduced and a degree of self-sufficiency of about 90% is achieved. Based on these findings, some scenarios to reach self-sufficiency are analyzed. The results show that full self-sufficiency will be possible with a seasonal hydrogen-based storage system if PV area and initial storage level are appropriate.

  3. The feasibility and challenges of energy self-sufficient wastewater treatment plants

    International Nuclear Information System (INIS)

    Gu, Yifan; Li, Yue; Li, Xuyao; Luo, Pengzhou; Wang, Hongtao; Robinson, Zoe P.; Wang, Xin; Wu, Jiang; Li, Fengting

    2017-01-01

    Highlights: •Various influencing factors of energy use in WWTPs are characterized. •Benchmark energy consumption in WWTPs in different countries are highlighted. •Energy recovery or saving technologies in WWTPs are summarized. •Recent advances in optimization of energy recovery technologies are highlighted. •Feasibility and challenges of energy self-sufficient WWTPs are explored. -- Abstract: Energy efficiency optimization is crucial for wastewater treatment plants (WWTPs) because of increasing energy costs and concerns about global climate change. Energy efficiency optimization can be achieved through a combination of energy recovery from the wastewater treatment process and energy saving-related technologies. Through these two approaches energy self-sufficiency of WWTPs is achievable, and research is underway to reduce operation costs and energy consumption and to achieve carbon neutrality. In this paper, we analyze energy consumption and recovery in WWTPs and characterize the factors that influence energy use in WWTPs, including treatment techniques, treatment capacities, and regional differences. Recent advances in the optimization of energy recovery technologies and theoretical analysis models for the analysis of different technological solutions are presented. Despite some challenges in implementation, such as technological barriers and high investment costs, particularly in developing countries, this paper highlights the potential for more energy self-sufficient WWTPs to be established in the future.

  4. Can New Zealand achieve self-sufficiency in its nursing workforce?

    Science.gov (United States)

    North, Nicola

    2011-01-01

    This paper reviews impacts on the nursing workforce of health policy and reforms of the past two decades and suggests reasons for both current difficulties in retaining nurses in the workforce and measures to achieve short-term improvements. Difficulties in retaining nurses in the New Zealand workforce have contributed to nursing shortages, leading to a dependence on overseas recruitment. In a context of global shortages and having to compete in a global nursing labour market, an alternative to dependence on overseas nurses is self-sufficiency. Discursive paper. Analysis of nursing workforce data highlighted threats to self-sufficiency, including age structure, high rates of emigration of New Zealand nurses with reliance on overseas nurses and an annual output of nurses that is insufficient to replace both expected retiring nurses and emigrating nurses. A review of recent policy and other documents indicates that two decades of health reform and lack of a strategic focus on nursing has contributed to shortages. Recent strategic approaches to the nursing workforce have included workforce stocktakes, integrated health workforce development and nursing workforce projections, with a single authority now responsible for planning, education, training and development for all health professions and sectors. Current health and nursing workforce development strategies offer wide-ranging and ambitious approaches. An alternative approach is advocated: based on workforce data analysis, pressing threats to self-sufficiency and measures available are identified to achieve, in the short term, the maximum impact on retaining nurses. A human resources in health approach is recommended that focuses on employment conditions and professional nursing as well as recruitment and retention strategies. Nursing is identified as 'crucial' to meeting demands for health care. A shortage of nurses threatens delivery of health services and supports the case for self-sufficiency in the nursing

  5. ADJUNCTIVE THERAPY OF COMMUNITY-ACKUIRED PNEUMONIA: NECESSITY AND SUFFICIENCY

    Directory of Open Access Journals (Sweden)

    L. V. Savchenkova

    2016-01-01

      failures  at both the outpatient  and  inpatient, which  significantly increases the cost of treatment. From the standpoint of evidence-based medicine is justified by the  inclusion in the  treatment of communityacquired pneumonia, only a mucolytic drugs and indications NSAIDs as an antipyretic and analgesic short course. The use of most drugs of pathogenic therapy do not have the evidence base  and  the  efficiency of their  purpose can not  be considered reasonable. In this case, the analysis can serve as a basis for planning a set of measures for improvement of pharmacotherapy community-acquired pneumonia based on the principle of minimal sufficiency

  6. How elements up to 118 were reached and how to go beyond

    Directory of Open Access Journals (Sweden)

    Düllmann Christoph E.

    2017-01-01

    Full Text Available The new superheavy elements with Z=113, 115, 117, and 118 were recently accepted into the periodic table and have been named. Elements with Z≥112 are predominantly produced in 48Ca-induced fusion reactions on actinide targets. This pathway is exhausted at Z=118 due to the lack of target materials with sufficiently high proton number to reach elements with Z≥119. Search experiments for yet heavier elements were performed at GSI Darmstadt and FLNR Dubna. The reactions 50Ti + 249Bk, which leads to Z=119, as well as 64Ni + 238U, 58Fe + 244Pu, 54Cr + 248Cm, and 50Ti + 249Cf, leading to Z=120, have been studied. Despite a total duration of these experiments of more than one year, neither succeeded in the identification of a new element. To obtain improved guidance for better-informed search experiments, nuclear reaction studies appear necessary and have recently started. Also technical advances will be an important pillar to this end. At GSI, work towards a new continuous-wave linear accelerator is ongoing and is briefly described.

  7. How elements up to 118 were reached and how to go beyond

    Science.gov (United States)

    Düllmann, Christoph E.

    2017-11-01

    The new superheavy elements with Z=113, 115, 117, and 118 were recently accepted into the periodic table and have been named. Elements with Z≥112 are predominantly produced in 48Ca-induced fusion reactions on actinide targets. This pathway is exhausted at Z=118 due to the lack of target materials with sufficiently high proton number to reach elements with Z≥119. Search experiments for yet heavier elements were performed at GSI Darmstadt and FLNR Dubna. The reactions 50Ti + 249Bk, which leads to Z=119, as well as 64Ni + 238U, 58Fe + 244Pu, 54Cr + 248Cm, and 50Ti + 249Cf, leading to Z=120, have been studied. Despite a total duration of these experiments of more than one year, neither succeeded in the identification of a new element. To obtain improved guidance for better-informed search experiments, nuclear reaction studies appear necessary and have recently started. Also technical advances will be an important pillar to this end. At GSI, work towards a new continuous-wave linear accelerator is ongoing and is briefly described.

  8. ESO telbib: Linking In and Reaching Out

    Science.gov (United States)

    Grothkopf, U.; Meakins, S.

    2015-04-01

    Measuring an observatory's research output is an integral part of its science operations. Like many other observatories, ESO tracks scholarly papers that use observational data from ESO facilities and uses state-of-the-art tools to create, maintain, and further develop the Telescope Bibliography database (telbib). While telbib started out as a stand-alone tool mostly used to compile lists of papers, it has by now developed into a multi-faceted, interlinked system. The core of the telbib database is links between scientific papers and observational data generated by the La Silla Paranal Observatory residing in the ESO archive. This functionality has also been deployed for ALMA data. In addition, telbib reaches out to several other systems, including ESO press releases, the NASA ADS Abstract Service, databases at the CDS Strasbourg, and impact scores at Altmetric.com. We illustrate these features to show how the interconnected telbib system enhances the content of the database as well as the user experience.

  9. Using New Media to Reach Broad Audiences

    Science.gov (United States)

    Gay, P. L.

    2008-06-01

    The International Year of Astronomy New Media Working Group (IYA NMWG) has a singular mission: To flood the Internet with ways to learn about astronomy, interact with astronomers and astronomy content, and socially network with astronomy. Within each of these areas, we seek to build lasting programs and partnerships that will continue beyond 2009. Our weapon of choice is New Media. It is often easiest to define New Media by what it is not. Television, radio, print and their online redistribution of content are not New Media. Many forms of New Media start as user provided content and content infrastructures that answer that individual's creative whim in a way that is adopted by a broader audience. Classic examples include Blogs and Podcasts. This media is typically distributed through content specific websites and RSS feeds, which allow syndication. RSS aggregators (iTunes has audio and video aggregation abilities) allow subscribers to have content delivered to their computers automatically when they connect to the Internet. RSS technology is also being used in such creative ways as allowing automatically updating Google-maps that show the location of someone with an intelligent GPS system, and in sharing 100 word microblogs from anyone (Twitters) through a single feed. In this poster, we outline how the IYA NMWG plans to use New Media to reach target primary audiences of astronomy enthusiasts, image lovers, and amateur astronomers, as well as secondary audiences, including: science fiction fans, online gamers, and skeptics.

  10. Has Athletic Performance Reached its Peak?

    Science.gov (United States)

    Berthelot, Geoffroy; Sedeaud, Adrien; Marck, Adrien; Antero-Jacquemin, Juliana; Schipman, Julien; Saulière, Guillaume; Marc, Andy; Desgorces, François-Denis; Toussaint, Jean-François

    2015-09-01

    Limits to athletic performance have long been a topic of myth and debate. However, sport performance appears to have reached a state of stagnation in recent years, suggesting that the physical capabilities of humans and other athletic species, such as greyhounds and thoroughbreds, cannot progress indefinitely. Although the ultimate capabilities may be predictable, the exact path for the absolute maximal performance values remains difficult to assess and relies on technical innovations, sport regulation, and other parameters that depend on current societal and economic conditions. The aim of this literature review was to assess the possible plateau of top physical capabilities in various events and detail the historical backgrounds and sociocultural, anthropometrical, and physiological factors influencing the progress and regression of athletic performance. Time series of performances in Olympic disciplines, such as track and field and swimming events, from 1896 to 2012 reveal a major decrease in performance development. Such a saturation effect is simultaneous in greyhound, thoroughbred, and frog performances. The genetic condition, exhaustion of phenotypic pools, economic context, and the depletion of optimal morphological traits contribute to the observed limitation of physical capabilities. Present conditions prevailing, we approach absolute physical limits and endure a continued period of world record scarcity. Optional scenarios for further improvements will mostly depend on sport technology and modification competition rules.

  11. LEP Dismantling Reaches Half-Way Stage

    CERN Multimedia

    2001-01-01

    LEP's last superconducting module leaves its home port... Just seven months into the operation, LEP dismantling is forging ahead. Two of the eight arcs which form the tunnel have already been emptied and the last of the accelerator's radiofrequency (RF) cavities has just been raised to the surface. The 160 people working on LEP dismantling have reason to feel pleased with their progress. All of the accelerator's 72 superconducting RF modules have already been brought to the surface, with the last one being extracted on 2nd May. This represents an important step in the dismantling process, as head of the project, John Poole, explains. 'This was the most delicate part of the project, because the modules are very big and they could only come out at one place', he says. The shaft at point 1.8 through which the RF cavity modules pass is 18 metres in diameter, while each module is 11.5 metres long. Some modules had to travel more than 10 kilometres to reach the shaft. ... is lifted up the PM 1.8 shaft, after a m...

  12. CAST reaches milestone but keeps on searching

    CERN Multimedia

    CERN Courier (september 2011 issue)

    2011-01-01

    After eight years of searching for the emission of a dark matter candidate particle, the axion, from the Sun, the CERN Axion Solar Telescope (CAST) has fulfilled its original physics programme.   Members of the CAST collaboration in July, together with dipole-based helioscope. CAST, the world’s most sensitive axion helioscope, points a recycled prototype LHC dipole magnet at the Sun at dawn and dusk, looking for the conversion of axions to X-rays. It incorporates four state-of-the-art X-ray detectors: three Micromegas detectors and a pn-CCD imaging camera attached to a focusing X-ray telescope that was recovered from the German space programme (see CERN Courier April 2010).  Over the years, CAST has operated with the magnet bores - the location of the axion conversion - in different conditions: first in vacuum, covering axion masses up to 20 meV/c2, and then with a buffer gas (4He and later 3He) at various densities, finally reaching the goal of 1.17 eV/c2 on 22 ...

  13. Planning of the Extended Reach well Dieksand 2; Planung der Extended Reach Bohrung Dieksand 2

    Energy Technology Data Exchange (ETDEWEB)

    Frank, U.; Berners, H. [RWE-DEA AG, Hamburg (Germany). Drilling Team Mittelplate und Dieksand; Hadow, A.; Klop, G.; Sickinger, W. [Wintershall AG Erdoelwerke, Barnstdorf (Germany); Sudron, K.

    1998-12-31

    The Mittelplate oil field is located 7 km offshore the town of Friedrichskoog. Reserves are estimated at 30 million tonnes of oil. At a production rate of 2,500 t/d, it will last about 33 years. The transport capacity of the offshore platform is limited, so that attempts were made to enhance production by constructing the extended reach borehole Dieksand 2. Details are presented. (orig.) [Deutsch] Das Erdoelfeld Mittelplate liegt am suedlichen Rand des Nationalparks Schleswig Holsteinisches Wattenmeer, ca. 7000 m westlich der Ortschaft Friedrichskoog. Die gewinnbaren Reserven betragen ca. 30 Millionen t Oel. Bei einer Foerderkapazitaet von 2.500 t/Tag betraegt die Foerderdauer ca. 33 Jahre. Aufgrund der begrenzten Transportkapazitaeten von der Insel, laesst sich durch zusaetzliche Bohrungen von der kuenstlichen Insel Mittelplate keine entscheidende Erhoehung der Foerderkapazitaet erzielen. Ab Sommer 1996 wurde erstmals die Moeglichkeit der Lagerstaettenerschliessung von Land untersucht. Ein im Mai 1997 in Hamburg etabliertes Drilling Team wurde mit der Aufgabe betraut, die Extended Reach Bohrung Dieksand 2 zu planen und abzuteufen. Die Planungsphasen fuer die Extended Reach Bohrung Dieksand 2 wurden aufgezeigt. Die fuer den Erfolg einer Extended Reach Bohrung wichtigen Planungsparameter wurden erlaeutert. Es wurden Wege gezeigt, wie bei diesem Projekt technische und geologische Risiken in der Planung mit beruecksichtigt und nach Beginn der Bohrung weiter bearbeitet werden koennen. (orig.)

  14. Can coronal hole spicules reach coronal temperatures?

    Science.gov (United States)

    Madjarska, M. S.; Vanninathan, K.; Doyle, J. G.

    2011-08-01

    Aims: The present study aims to provide observational evidence of whether coronal hole spicules reach coronal temperatures. Methods: We combine multi-instrument co-observations obtained with the SUMER/SoHO and with the EIS/SOT/XRT/Hinode. Results: The analysed three large spicules were found to be comprised of numerous thin spicules that rise, rotate, and descend simultaneously forming a bush-like feature. Their rotation resembles the untwisting of a large flux rope. They show velocities ranging from 50 to 250 kms-1. We clearly associated the red- and blue-shifted emissions in transition region lines not only with rotating but also with rising and descending plasmas. Our main result is that these spicules although very large and dynamic, are not present in the spectral lines formed at temperatures above 300 000 K. Conclusions: In this paper we present the analysis of three Ca ii H large spicules that are composed of numerous dynamic thin spicules but appear as macrospicules in lower resolution EUV images. We found no coronal counterpart of these and smaller spicules. We believe that the identification of phenomena that have very different origins as macrospicules is due to the interpretation of the transition region emission, and especially the He ii emission, wherein both chromospheric large spicules and coronal X-ray jets are present. We suggest that the recent observation of spicules in the coronal AIA/SDO 171 Å and 211 Å channels probably comes from the existence of transition region emission there. Movie is available in electronic form at http://www.aanda.org

  15. The German REACH Congress 2016: a workshop report.

    Science.gov (United States)

    Reihlen, Antonia; Jepsen, Dirk; Broschinski, Lutz; Luch, Andreas; Schulte, Agnes

    2018-03-01

    In October 2016, the German REACH Congress was held at the German Federal Institute for Risk Assessment (BfR) in Berlin. Here, the associated improvement made in the fields of consumer protection and the progress in and experiences gained from the implementation of the authorisation procedure were discussed. Several speakers from EU institutions, German authorities, industry, and civil society organisations were invited to present their views. There was a shared consensus that REACH contributes to the advancement of consumer protection against chemical risks, mainly because more and higher quality information on substance-related hazards and potential exposures becomes available. In addition, risk management measures, particularly regarding restrictions on uses, scale down consumer exposures to chemicals. Opportunities for improvements identified at the congress include the quality of registration dossiers and the management of and communication on substances of very high concern (SVHC) that may be present in consumer articles. Although regarded as being in an early implementation phase, the authorisation process was generally found to be operational and progressing well. Criticism was expressed with regard to the consistency of authorisation decisions and the costs and uncertainties related to authorisation applications. Consumer protection legislation consists of several legal provisions which are interlinked. The congress participants agreed that REACH is an important element of this legal framework as it enhances and complements other legal provisions.

  16. Taking family planning services to hard-to-reach populations.

    Science.gov (United States)

    Donovan, P

    1996-01-01

    Interviews were conducted in 1995 among 100 US family planning program personnel who serve hard-to-reach populations, such as drug abusers, prisoners, the disabled, homeless persons, and non-English speaking minorities. Findings indicate that a range of services is available for hard-to-reach groups. Most family planning agencies focus on drug abusers because of the severity of HIV infections and the availability of funding. This article describes the activities of various agencies in Michigan, Pennsylvania, and Massachusetts that serve substance abuse centers with family planning services. One recommendation for a service provider is to present services in an environment where it is safe to talk about a person's needs. One other program offered personal greetings upon arrival and the continuity of having a familiar face to oversee all reproductive and health needs. Programs for prisoners ranged from basic sex education classes to comprehensive reproductive health care. Some prisons offered individual counseling. Some programs were presented in juvenile offender facilities. Outreach to the homeless involved services at homeless shelters, outreach workers who recruited women into traditional family planning clinics, and establishment of nontraditional sites for the homeless and other hard-to-reach persons. One provider's suggestion was to offer services where high-risk women already go for other services. Most services to the disabled target the developmentally disabled rather than the physically disabled. Experience has shown that many professionals working with the disabled do not recognize their clients' sexual needs. Other hard-to-reach groups include women in housing projects and shelters for battered women, welfare applicants, and sex workers. Key to service provision is creating trust, overcoming language and cultural differences, and subsidizing the cost of care.

  17. Access to expert stroke care with telemedicine: REACH MUSC

    Directory of Open Access Journals (Sweden)

    Abby Swanson Kazley

    2012-03-01

    Full Text Available Stroke is a leading cause of death and disability, and rtPA can significantly reduce the long-term impact of acute ischemic stroke (AIS if given within 3 hours of symptom onset. South Carolina is located in the stroke belt and has a high rate of stroke and stroke mortality. Many small rural SC hospitals do not maintain the expertise needed to treat AIS patients with rtPA. MUSC is an academic medical center using REACH MUSC telemedicine to deliver stroke care to 15 hospitals in the state, increasing the likelihood of timely treatment with rtPA. The purpose of this study is to determine the increase in access to rtPA through the use of telemedicine for AIS in the general population and in specific segments of the population based on age, gender, race, ethnicity, education, urban/rural residence, poverty, and stroke mortality.We used a retrospective cross-sectional design examining Census data from 2000 and Geographic Information Systems (GIS analysis to identify South Carolina residents that live within 30 or 60 minutes of a Primary Stroke Center (PSC or a REACH MUSC site. We include all South Carolina citizens in our analysis and specifically examine the population’s age, gender, race, ethnicity, education, urban/rural residence, poverty, and stroke mortality. Our sample includes 4,012,012 South Carolinians. The main measure is access to expert stroke care at a Primary Stroke Center (PSC or a REACH MUSC hospital within 30 or 60 minutes. We find that without REACH MUSC, only 38% of the population has potential access to expert stroke care in SC within sixty minutes given that most PSCs will maintain expert stroke coverage. REACH MUSC allows 76% of the population to be within sixty minutes of expert stroke care, and 43% of the population to be within 30 minute drive time of expert stroke care. These increases in access are especially significant for groups that have faced disparities in care and high rates of AIS. The use of telemedicine can

  18. Reaching remote areas in Latin America.

    Science.gov (United States)

    Jaimes, R

    1994-01-01

    Poor communities in remote and inaccessible areas tend to not only be cut off from family planning education and services, but they are also deprived of basic primary health care services. Efforts to bring family planning to such communities and populations should therefore be linked with other services. The author presents three examples of programs to bring effective family planning services to remote communities in Central and South America. Outside of the municipal center in the Tuxtlas region of Mexico, education and health levels are low and people live according to ancient customs. Ten years ago with the help of MEXFAM, the IPPF affiliate in Mexico, two social promoters established themselves in the town of Catemaco to develop a community program of family planning and health care offering education and prevention to improve the quality of people's lives. Through their health brigades taking health services to towns without an established health center, the program has influenced an estimated 100,000 people in 50 villages and towns. The program also has a clinic. In Guatemala, the Family Welfare Association (APROFAM) gave bicycles to 240 volunteer health care workers to facilitate their outreach work in rural areas. APROFAM since 1988 has operated an integrated program to treat intestinal parasites and promote family planning in San Lucas de Toliman, an Indian town close to Lake Atitlan. Providing health care to more than 10,000 people, the volunteer staff has covered the entire department of Solola, reaching each family in the area. Field educators travel on motorcycles through the rural areas of Guatemala coordinating with the health volunteers the distribution of contraceptives at the community level. The Integrated Project's Clinic was founded in 1992 and currently carries out pregnancy and Pap tests, as well as general lab tests. Finally, Puna is an island in the middle of the Gulf of Guayaquil, Ecuador. Women on the island typically have 10

  19. Functional reach and lateral reach tests adapted for aquatic physical therapy

    Directory of Open Access Journals (Sweden)

    Ana Angélica Ribeiro de Lima

    Full Text Available Abstract Introduction: Functional reach (FR and lateral reach (LR tests are widely used in scientific research and clinical practice. Assessment tools are useful in assessing subjects with greater accuracy and are usually adapted according to the limitations of each condition. Objective: To adapt FR and LR tests for use in an aquatic environment and assess the performance of healthy young adults. Methods: We collected anthropometric data and information on whether the participant exercised regularly or not. The FR and LR tests were adapted for use in an aquatic environment and administered to 47 healthy subjects aged 20-30 years. Each test was repeated three times. Results: Forty-one females and six males were assessed. The mean FR test score for men was 24.06 cm, whereas the mean value for right lateral reach (RLR was 10.94 cm and for left lateral reach (LLR was 9.78 cm. For females, the mean FR score was 17.57 cm, while the mean values for RLR was 8.84cm and for LLR was 7.76 cm. Men performed better in the FR (p < 0.001 and RLR tests than women (p = 0.037. Individuals who exercised regularly showed no differences in performance level when compared with their counterparts. Conclusion: The FR and LR tests were adapted for use in an aquatic environment. Males performed better on the FR and RLR tests, when compared to females. There was no correlation between the FR and LR tests and weight, height, Body Mass Index (BMI, foot length or length of the dominant upper limb.

  20. Agreement reached on integrated safeguards in European Union

    International Nuclear Information System (INIS)

    2010-01-01

    Full text: The International Atomic Energy Agency (IAEA), in cooperation with the European Commission, has reached agreement on arrangements to implement 'integrated safeguards' in all non-nuclear-weapon States of the European Union with significant nuclear activities. 'This important milestone is the result of the constructive common efforts of all parties concerned. It is a clear signal of the importance attributed by the EU and its Member States, as well as the IAEA, to the reinforcement of the nuclear non-proliferation regime,' said Andris Piebalgs, Member of the European Commission in charge of Energy. 'Once we have sufficient confidence that a State' s nuclear activities are purely peaceful, we can apply safeguards measures in a less prescriptive, more customised manner. This reduces the inspection burden on the State and the inspection effort of the IAEA, while enabling the IAEA to maintain the conclusion that all nuclear material has remained in peaceful activities,' said Olli Heinonen, Deputy Director General and Head of IAEA Safeguards Department. Background The Nuclear Non-Proliferation Treaty (NPT) is the main international Treaty prohibiting the spread of nuclear weapons. It entrusts the IAEA to verify that nuclear material is not diverted to nuclear weapons or other nuclear explosive devices through the application of 'safeguards'. IAEA safeguards include comprehensive safeguards agreements and additional protocols that enable the IAEA to conclude that all nuclear material has remained in peaceful activities in a State. Integrated Safeguards refers to the optimum combination of all safeguards measures available to the Agency under comprehensive safeguards agreements and additional protocols to achieve maximum effectiveness and efficiency in meeting the Agency ' s safeguards obligations. In the European Union, nuclear safeguards are implemented on the basis of the Euratom Treaty and trilateral agreements between Euratom, its Member States and the IAEA

  1. Avoiding a knowledge gap in a multiethnic statewide social marketing campaign: is cultural tailoring sufficient?

    Science.gov (United States)

    Buchthal, O Vanessa; Doff, Amy L; Hsu, Laura A; Silbanuz, Alice; Heinrich, Katie M; Maddock, Jay E

    2011-03-01

    In 2007, the State of Hawaii, Healthy Hawaii Initiative conducted a statewide social-marketing campaign promoting increased physical activity and nutrition. The campaign included substantial formative research to develop messages tailored for Hawaii's multiethnic Asian and Pacific Islander populations. The authors conducted a statewide random digital dialing telephone survey to assess the campaign's comparative reach among individuals with different ethnicities and different levels of education and income. This analysis suggests that the intervention was successful in reaching its target ethnic audiences. However, a knowledge gap related to the campaign appeared among individuals with incomes less than 130% of the poverty level and those with less than a high school education. These results varied significantly by message and the communication channel used. Recall of supermarket-based messages was significantly higher among individuals below 130% of the poverty level and those between 18 and 35 years of age, 2 groups that showed consistently lower recall of messages in other channels. Results suggest that cultural tailoring for ethnic audiences, although important, is insufficient for reaching low-income populations, and that broad-based social marketing campaigns should consider addressing socioeconomic status-related channel preferences in formative research and campaign design.

  2. Development of the quality of reaching in infants with cerebral palsy : a kinematic study

    NARCIS (Netherlands)

    Boxum, Anke G; La Bastide-Van Gemert, Sacha; Dijkstra, Linze-Jaap; Hamer, Elisa G; Hielkema, Tjitske; Reinders-Messelink, Heleen A; Hadders-Algra, Mijna

    2017-01-01

    AIM: To assess development of reaching and head stability in infants at very high risk (VHR-infants) of cerebral palsy (CP) who did and did not develop CP. METHOD: This explorative longitudinal study assessed the kinematics of reaching and head sway in sitting in 37 VHR-infants (18 CP) one to four

  3. From constraint to sufficiency. The decoupling of energy and carbon from human needs, 1975-2005

    Energy Technology Data Exchange (ETDEWEB)

    Steinberger, Julia K. [Institute of Social Ecology, University of Klagenfurt, Vienna (Austria); Roberts, J. Timmons [Center for Environmental Studies, Brown University, Providence, RI (United States)

    2010-12-15

    We investigate the relationship between human needs, energy consumption and carbon emissions for several indicators of human development: life expectancy, literacy, income and the Human Development Index. We find that high human development can be achieved at moderate energy and carbon levels; increasing energy and carbon past this level does not necessarily contribute to higher living standards. By conducting a novel longitudinal analysis from 1975 to 2005, we observe a previously undetected decoupling of the per capita energy and carbon required for human needs. If resources were equally distributed, current energy and carbon levels would be more than sufficient to satisfy global human needs at high levels of human development. By projecting current trends to 2030, we demonstrate that the global energy consumption and carbon emissions required to satisfy human needs will decrease with time, despite growth in population. (author)

  4. Impact of Market Behavior, Fleet Composition, and Ancillary Services on Revenue Sufficiency

    Energy Technology Data Exchange (ETDEWEB)

    Frew, Bethany [National Renewable Energy Lab. (NREL), Golden, CO (United States); Gallo, Giulia [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brinkman, Gregory [National Renewable Energy Lab. (NREL), Golden, CO (United States); Milligan, Michael [National Renewable Energy Lab. (NREL), Golden, CO (United States); Clark, Kara [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bloom, Aaron [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-06-01

    analysis also shows that generators face revenue sufficiency challenges in this ERCOT-like energy-only market model; net revenues provided by the market in all base markup cases and sensitivity scenarios (except when a large fraction of the existing coal fleet is retired) are not sufficient to justify investments in new capacity for thermal and nuclear power units. Overall, the work described in this paper points to the need for improved behavioral models of electricity markets to more accurately study current and potential market design issues that could arise in systems with high penetrations of renewable generation.

  5. CERN and UNESCO reach out to Rwanda

    CERN Multimedia

    2009-01-01

    CERN already has a successful relationship with some African countries. However, much remains to be done to improve the dialogue with that continent. A recent trip to Rwanda provided a new opportunity to share knowledge and technology and create a connection that may last for many years. CERN’s Jean-Yves Le Meur, second from the right, teaches participants how to install the digital library system on their computers.In addition to physics research, CERN’s key missions also include training and international collaboration. Recently, thanks to funding from UNESCO, CERN’s Scientific Information Service was able to provide face-to-face training of digital library software developed at CERN, and the CERN Education Group organised a two-day high-school teacher training programme. "Many African countries are in the process of digitising their libraries," explains John Ellis, CERN’s Coordinator for non-Member States. "A workshop was ...

  6. THE LONG REACH OF EDUCATION: EARLY RETIREMENT.

    Science.gov (United States)

    Venti, Steven; Wise, David A

    2015-12-01

    The goal of this paper is to draw attention to the long lasting effect of education on economic outcomes. We use the relationship between education and two routes to early retirement - the receipt of Social Security Disability Insurance (DI) and the early claiming of Social Security retirement benefits - to illustrate the long-lasting influence of education. We find that for both men and women with less than a high school degree the median DI participation rate is 6.6 times the participation rate for those with a college degree or more. Similarly, men and women with less than a high school education are over 25 percentage points more likely to claim Social Security benefits early than those with a college degree or more. We focus on four critical "pathways" through which education may indirectly influence early retirement - health, employment, earnings, and the accumulation of assets. We find that for women health is the dominant pathway through which education influences DI participation. For men, the health, earnings, and wealth pathways are of roughly equal magnitude. For both men and women the principal channel through which education influences early Social Security claiming decisions is the earnings pathway. We also consider the direct effect of education that does not operate through these pathways. The direct effect of education is much greater for early claiming of Social Security benefits than for DI participation, accounting for 72 percent of the effect of education for men and 67 percent for women. For women the direct effect of education on DI participation is not statistically significant, suggesting that the total effect may be through the four pathways.

  7. Fuel self-sufficient and low proliferation risk multi-recycling of spent fuel

    International Nuclear Information System (INIS)

    Cho, N. Z.; Hong, S. G.; Kim, T. H.; Greenspan, E.; Kastenberg, W. E.

    1998-01-01

    A preliminary feasibility study has been performed in search of promising nuclear energy systems which could make efficient use of the spent fuel from LWRs and be proliferation resistant. The energy considered consist of a dry process and a fuel-self-sufficient reactor which are synergistic. D 2 O, H 2 O and Pb (or Pb-Bi) are considered for the coolant. The most promising identified consists of Pb-cooled reactors with either an AIROX or an IFR-like reprocessing. H 2 O- (possibly mixed with D 2 O) cooled reactors can be designed to be fuel-self-sufficient and multi-recycle LWR spent fuel, provided they are accelerator driven. Moderator-free, D 2 O-cooled critical reactors can multi-recycle Th- 233 U fuel using IFR-type reprocessing; they are significantly more attractive than their thermal counterparts. H 2 O- (possibly mixed with D 2 O) cooled, accelerator-driven reactors appear attractive for converting Th into denatured 233 U using LWR spent fuel and the IFR process. The CANDU reactor technology appears highly synergistic with accelerator-driven systems. (author). 25 refs., 3 tabs., 6 figs

  8. Guaranteed performance in reaching mode of sliding mode ...

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    addresses the design of constant plus proportional rate reaching law-based SMC for second-order ... Reaching mode; sliding mode controlled systems; output tracking ... The uncertainty in the input distribution function g is expressed as.

  9. Nanomaterials under REACH. Nanosilver as a case study

    NARCIS (Netherlands)

    Pronk MEJ; Wijnhoven SWP; Bleeker EAJ; Heugens EHW; Peijnenburg WJGM; Luttik R; Hakkert BC; SEC; SIR; LER

    2009-01-01

    Om de risico's van nanomaterialen te kunnen inschatten en beheersen, zijn enkele aanpassingen nodig in de Europese chemicalienwetgeving REACH. De gegevens over stoffen waar REACH standaard om vraagt, zijn namelijk onvoldoende om de specifieke eigenschappen van nanomaterialen te bepalen. Hetzelfde

  10. Reaching Adolescents and Youth in Burkina Faso, Guinea-Bissau

    African Journals Online (AJOL)

    AJRH Managing Editor

    typical profile of individuals in contact with peer educators or attending youth ... being reached (versus not reached) by programs ... characteristics in order to serve groups that may be ... places for counseling services but the frequency of.

  11. Discovery Reach for Black Hole Production

    CERN Document Server

    The ATLAS collaboration

    2009-01-01

    Models with extra space dimensions, in which our Universe exists on a 4-dimensional brane embedded in a higher dimensional bulk space-time, offer a new way to address outstanding problems in and beyond the Standard Model. In such models the Planck scale in the bulk can be of the order of the electroweak symmetry breaking scale. This allows the coupling strength of gravity to increase to a size similar to the other interactions, opening the way to the unification of gravity and the gauge interactions. The increased strength of gravity in the bulk space-time means that quantum gravity effects would be observable in the TeV energy range reachable by the LHC. The most spectacular phenomenon would be the production of black holes, which would decay semi-classically by Hawking radiation emitting high energy particles. In this note, we discuss the potential for the ATLAS experiment to discover such black holes in the early data (1--1000 pb$^{-1}$).

  12. Do new and renovated schools and kindergartens secure sufficiently high indoor environmental quality?

    DEFF Research Database (Denmark)

    Wargocki, Pawel; Hviid, Christian Anker; Skupien, Agata

    2016-01-01

    or less similar as their conventional counterparts as regards measured parameters of indoor environment. Subjective evaluations made by pupils and teachers did not always match the physical measurements. There were also differences in subjective evaluations made by children and by teachers. In conclusion...

  13. Meningkatkan Kematangan Karier Peserta Didik SMA dengan Pelatihan Reach Your Dreams dan Konseling Karier

    Directory of Open Access Journals (Sweden)

    Ahmad Saifuddin

    2017-04-01

    Full Text Available Career maturity is a condition that needed to choice the program in higher level study. Henceforth, the low level of career maturity in senior high school student has to be solved with the comprehensive intervention as soon as possible. The purpose of this research is to know the effectivity of Reach Your Dreams Training and career counseling for improving career maturity in senior high school student. This research used Solomon Six Group Design. Subjects of this research are 42 senior high school students with average level of career maturity who are divided into two groups given Reach Your Dreams Training, two groups given career counseling, and two control groups. According to the result, the conclusion of this research is Reach Your Dreams Training and Counseling Career can improve career maturity level in senior high school students effectively. It is caused by the effect of Reach Your Dreams Training and career counseling, and not caused by the effect of pretest.

  14. Benthic metabolism and denitrification in a river reach: a comparison between vegetated and bare sediments

    Directory of Open Access Journals (Sweden)

    Pierluigi VIAROLI

    2009-02-01

    Full Text Available This study aims at comparing biogeochemical processes in a Vallisneria spiralis meadow and in unvegetated sediments in the upper reach of the Mincio River (Northern Italy. The main hypothesis of this work is that meadows of rooted macrophytes affect benthic metabolism, enhancing capacity to retain nutrients (assimilation and dissipate (denitrification nitrogen loadings. In order to highlight how plants affect benthic processes in the riverbed, oxygen, dissolved inorganic carbon (DIC, soluble reactive phosphorus (SRP and inorganic nitrogen fluxes, together with denitrification rates, were measured from February to November 2007 in intact cores collected from stands of V. spiralis and bare sediments. V. spiralis biomass, elemental composition and growth rates were concurrently measured. Macrophyte biomass ranged from 60 to 120 g m-2 (as dry matter; growth rates followed a seasonal pattern from 0.001 in winter up to 0.080 d-1 in summer. On an annual basis, the macrophyte meadow was autotrophic with net O2 production and dissolved inorganic carbon uptake, while the bare sediment was net heterotrophic. The concurrent N assimilation by macrophytes and losses through denitrification led to similar N uptake/dissipation rates, up to 2500 mmol m-2 y-1. Under the very high NO3 - concentrations of the Mincio River, the competition between primary production and denitrification processes was also avoided. A significant ammonium regeneration from sediments to the water column occurred in the V. spiralis meadow, where plant debris and particulate matter accumulated. Here, SRP was also released into the water column, whilst in the bare sediment SRP fluxes were close to zero. Overall, V. spiralis affected the benthic metabolism enhancing the ecosystem capacity to control nitrogen contamination. However, the actual N removal rates were not sufficient to mitigate the pollution discharge.

  15. Reaching out to the hard to reach: using a science centre model to deliver public engagement with research.

    Science.gov (United States)

    Gagen, M.; Allton, C.; Bryan, W. A.; O'Leary, M.

    2017-12-01

    Science communication is at an all-time high but public faith in expertise is low. However, within this climate of suspicion, research scientists remain a publicly trusted expert group. While there is both academic and public appetite for Public Engagement with Research (PER), there are barriers to reaching a wide range of publics. Attempts to connect the public with research often end up targeting the `already engaged'; the hard-to-reach remain just that. Engaging scientific curiosity in a wider demographic is crucial to promote scientific curiosity, itself known to profoundly counter the politically motivated reasoning that threatens informed debate around contemporary environmental issues. This requires the creation of opportunities for the public to engage with research in places in which they feel they belong. We report here on an 8 month pilot of a science centre model for PER. Oriel Science (www.orielscience.co.uk) is a research-led science exhibition in Swansea city centre delivering Swansea University's PER and run by academics and student ambassadors. Oriel Science (Oriel is Gallery in Welsh) received 16,000 visitors in 8 months, 40% of whom had no previous interaction with the university or its research and >40% of whom came from socio-economically deprived areas. We report on the public engagement leadership we enabled, working with 18 research groups over 8 months and our achievements in giving a broad range of publics the most direct access to participate in contemporary science.

  16. Naturalness reach of the large hadron collider in minimal supergravity

    International Nuclear Information System (INIS)

    Allanach, B.C.; Hetherington, J.P.J.; Parker, M.A.; Webber, B.R.

    2000-01-01

    We re-analyse the prospects of discovering supersymmetry at the LHC, in order to re-express coverage in terms of a fine-tuning parameter and to extend the analysis to scalar masses (m 0 ) above 2 TeV. We use minimal supergravity (mSUGRA) unification assumptions for the SUSY breaking parameters. Such high values of m 0 have recently been found to have a focus point, leading to relatively low fine-tuning. In addition, improvements in the simulations since the last study mean that this region no longer lacks radiative electroweak symmetry breaking. The best fine tuning reach is found in a mono-leptonic channel, where for μ>0, A 0 =0 and tan β=10 (corresponding to the focus point), all points in mSUGRA with m 0 0 , mSUGRA does not evade detection provided the gaugino mass parameter M 1/2 < 460 GeV. (author)

  17. SUFFICIENT IODINE INTAKE IN SCHOOLCHILDREN FROM THE ZAGREB AREA: ASSESSMENT WITH DRIED BLOD SPOT THYROGLOBULIN AS A NEW FUNCTIONAL BIOMARKER FOR IODINE DEFICIENCY.

    Science.gov (United States)

    Jukić, Tomislav; Zimmermann, Michael Bruce; Granić, Roko; Prpić, Marin; Krilić, Drazena; Juresa, Vesna; Katalenić, Marijan; Kusić, Zvonko

    2015-12-01

    Current methods for assessment of iodine intake in a population comprise measurements of urinary iodine concentration (UIC), thyroid volume by ultrasound (US-Tvol), and newborn TSH. Serum or dried blood spot thyroglobulin (DBS-Tg) is a new promising functional iodine status biomarker in children. In 1996, a new act on universal salt iodination was introduced in Croatia with 25 mg of potassium iodideper kg of salt. In 2002, Croatia finally reached iodine sufficiency. However, in 2009, median UIC in 101 schoolchildren from Zagreb, the capital of Croatia, was 288 µg/L, posing to be excessive. The aim of the study was to assess iodine intake in schoolchildren from the Zagreb area and to evaluate the value of DBS-Tg in schoolchildren as a new functional biomarker of iodine deficiency (and iodine excess). The study was part of a large international study in 6- to 12-year-old children supported by UNICEF, the Swiss Federal Institute of Technology (ETH Zurich) and the International Council for the Control of Iodine Deficiency Disorders (ICCIDD). According to international study results, the median cut-off Tg 40 µg/L indicate iodine sufficiency. The study included 159 schoolchildren (median age 9.1 ± 1.4 years) from Zagreb and a nearby small town of Jastrebarsko with measurements of UIC, US-Tvol, DBS-Tg, T4, TSH and iodine content in salt from households of schoolchildren (KI/kg of salt). Overall median UIC was 205 µg/L (range 1-505 µg/L). Thyroid volumes in schoolchildren measured by US were within the normal range according to reference values. Median DBS-Tg in schoolchildren was 12.1 µg/L with 3% of Tg values > 40 µg/L. High Tg values were in the UIC range 300 µg/L (U-shaped curve of Tg plotted against UIC). All children were euthyroid with geometric mean TSH 0.7 ± 0.3 mU/L and arithmetic mean T4 62 ± 12.5 nmol/L. The mean KI content per kg of salt was 24.9 ± 3.1 mg/kg (range 19-36 mg/kg). Study results indicated iodine sufficiency in schoolchildren from the

  18. The Relationship between Organizational Support Perceptions and Self-Sufficiencies of Logistics Sector Employees

    Directory of Open Access Journals (Sweden)

    Sefer Gumus

    2016-01-01

    Full Text Available This study was performed in order to examine the relationship between organizational support perceptions and self-sufficiency levels of logistics sector employees and to determine whether organizational support perceptions and self-sufficiency levels of employees differ according to some specification. The questionnaire form consisting of perceived organizational support scale in accordance with the purpose, general self-sufficiency scale and personal information form, was applied to 124 employees of 3 separate logistics firms operating in Istanbul. The data obtained from the questionnaire were analyzed using SPSS17.0 statistical software package on computer. In the assessment of data, descriptive characteristics of employees were determined by frequency and percentage statistics and the self-sufficiency and perceived organizational support levels by the mean and standard deviation statistics. The t test, Tukey test and one-way Anova tests were utilized in determining employees' self-sufficiency and perceived organizational support levels differentiation according to descriptive characteristics, and correlation analysis was utilized in determining the relationship between self-sufficiency and perceived organizational support levels of employees. In conclusion, it was determined that there was statistical relationship between organizational support and self-sufficiency levels perceived by logistics sector employees. Accordingly, when employees' perceived organizational support levels increase then self-sufficiency levels also increase, and when perceived organizational support levels decrease then self-sufficiency levels also decrease.

  19. Action plans can interact to hinder or facilitate reach performance.

    Science.gov (United States)

    Fournier, Lisa R; Wiediger, Matthew D; Taddese, Ezana F

    2015-11-01

    Executing a reach action can be delayed while retaining another action in working memory (WM) if the two action plans partly overlap rather than do not overlap. This delay (partial repetition cost) occurs when reach responses are under cognitive control. In this study, we investigated whether facilitation (a partial repetition benefit) occurs when reach responses are automatic. We also examined whether the hemisphere controlling the limb or selection of the preferred limb (based on a free-reach task) influences reach performance when the actions partly overlap. Left- and right-handers reached to different stimulus locations to the left and right of body midline with their ipsilateral hand while maintaining an action plan in WM that required the same or the different hand. The results showed a partial repetition benefit for spatially compatible reaches to left and right stimulus locations far from the body midline, but not for those near the body midline. Also, no partial repetition cost was found at any of the stimulus-reach locations. This indicates that automatic reach responses that partly overlap with an action plan maintained in WM are not delayed, but instead can be facilitated (partial repetition benefit). The roles of hemisphere and reach-hand preference in action control and the importance of the degree of feature overlap in obtaining a partial repetition benefit (and cost) are discussed.

  20. Delays in using chromatic and luminance information to correct rapid reaches.

    Science.gov (United States)

    Kane, Adam; Wade, Alex; Ma-Wyatt, Anna

    2011-09-07

    People can use feedback to make online corrections to movements but only if there is sufficient time to integrate the new information and make the correction. A key variable in this process is therefore the speed at which the new information about the target location is coded. Conduction velocities for chromatic signals are lower than for achromatic signals so it may take longer to correct reaches to chromatic stimuli. In addition to this delay, the sensorimotor system may prefer achromatic information over the chromatic information as delayed information may be less valuable when movements are made under time pressure. A down-weighting of chromatic information may result in additional latencies for chromatically directed reaches. In our study, participants made online corrections to reaches to achromatic, (L-M)-cone, and S-cone stimuli. Our chromatic stimuli were carefully adjusted to minimize stimulation of achromatic pathways, and we equated stimuli both in terms of detection thresholds and also by their estimated neural responses. Similar stimuli were used throughout the subjective adjustments and final reaching experiment. Using this paradigm, we found that responses to achromatic stimuli were only slightly faster than responses to (L-M)-cone and S-cone stimuli. We conclude that the sensorimotor system treats chromatic and achromatic information similarly and that the delayed chromatic responses primarily reflect early conduction delays.

  1. Dynamic model of the octopus arm. I. Biomechanics of the octopus reaching movement.

    Science.gov (United States)

    Yekutieli, Yoram; Sagiv-Zohar, Roni; Aharonov, Ranit; Engel, Yaakov; Hochner, Binyamin; Flash, Tamar

    2005-08-01

    The octopus arm requires special motor control schemes because it consists almost entirely of muscles and lacks a rigid skeletal support. Here we present a 2D dynamic model of the octopus arm to explore possible strategies of movement control in this muscular hydrostat. The arm is modeled as a multisegment structure, each segment containing longitudinal and transverse muscles and maintaining a constant volume, a prominent feature of muscular hydrostats. The input to the model is the degree of activation of each of its muscles. The model includes the external forces of gravity, buoyancy, and water drag forces (experimentally estimated here). It also includes the internal forces generated by the arm muscles and the forces responsible for maintaining a constant volume. Using this dynamic model to investigate the octopus reaching movement and to explore the mechanisms of bend propagation that characterize this movement, we found the following. 1) A simple command producing a wave of muscle activation moving at a constant velocity is sufficient to replicate the natural reaching movements with similar kinematic features. 2) The biomechanical mechanism that produces the reaching movement is a stiffening wave of muscle contraction that pushes a bend forward along the arm. 3) The perpendicular drag coefficient for an octopus arm is nearly 50 times larger than the tangential drag coefficient. During a reaching movement, only a small portion of the arm is oriented perpendicular to the direction of movement, thus minimizing the drag force.

  2. Reaching the global target to reduce stunting: an investment framework.

    Science.gov (United States)

    Shekar, Meera; Kakietek, Jakub; D'Alimonte, Mary R; Rogers, Hilary E; Eberwein, Julia Dayton; Akuoku, Jon Kweku; Pereira, Audrey; Soe-Lin, Shan; Hecht, Robert

    2017-06-01

    Childhood stunting, being short for one's age, has life-long consequences for health, human capital and economic growth. Being stunted in early childhood is associated with slower cognitive development, reduced schooling attainment and adult incomes decreased by 5-53%. The World Health Assembly has endorsed global nutrition targets including one to reduce the number of stunted children under five by 40% by 2025. The target has been included in the Sustainable Development Goals (SDG target 2.2). This paper estimates the cost of achieving this target and develops scenarios for generating the necessary financing. We focus on a key intervention package for stunting (KIPS) with strong evidence of effectiveness. Annual scale-up costs for the period of 2016-25 were estimated for a sample of 37 high burden countries and extrapolated to all low and middle income countries. The Lives Saved Tool was used to model the impact of the scale-up on stunting prevalence. We analysed data on KIPS budget allocations and expenditure by governments, donors and households to derive a global baseline financing estimate. We modelled two financing scenarios, a 'business as usual', which extends the current trends in domestic and international financing for nutrition through 2025, and another that proposes increases in financing from all sources under a set of burden-sharing rules. The 10-year financial need to scale up KIPS is US$49.5 billion. Under 'business as usual', this financial need is not met and the global stunting target is not reached. To reach the target, current financing will have to increase from US$2.6 billion to US$7.4 billion a year on average. Reaching the stunting target is feasible but will require large coordinated investments in KIPS and a supportive enabling environment. The example of HIV scale-up over 2001-11 is instructive in identifying the factors that could drive such a global response to childhood stunting. © The Author 2017. Published by Oxford University

  3. Reach/frequency for printed media: Personal probabilities or models

    DEFF Research Database (Denmark)

    Mortensen, Peter Stendahl

    2000-01-01

    The author evaluates two different ways of estimating reach and frequency of plans for printed media. The first assigns reading probabilities to groups of respondents and calculates reach and frequency by simulation. the second estimates parameters to a model for reach/frequency. It is concluded ...... and estiamtes from such models are shown to be closer to panel data. the problem, however, is to get valid input for such models from readership surveys. Means for this are discussed....

  4. 33 CFR 115.30 - Sufficiency of State authority for bridges.

    Science.gov (United States)

    2010-07-01

    ... for bridges. 115.30 Section 115.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.30 Sufficiency of State authority for bridges. An opinion of the attorney general of the State as to the sufficiency of State...

  5. Raising objectives: how global PV production could reach 5 GWp by 2010

    International Nuclear Information System (INIS)

    Cameron, A.; Jones, J.

    2006-01-01

    A recent international workshop for the solar photovoltaic (PV) industry organised by the European Photovoltaic Industry Association (EPIA) examined market trends and technological developments. Under a business-as-usual (BAU) scenario, the EPIA predicts that the global PV market would only reach 3.2 GWp by 2010. But workshop participants believe that, given sufficient support measures to encourage investment, the global market could be accelerated to reach 5400 MW per year by 2010, with an achievable annual installed capacity of over 5 GWp and production of 30,000 tonnes of solar-grade silicon per year at a cost of 30-40 euros/kg. Major markets are expected to be Germany, Japan, USA, China and Spain. Examples of the type of policies and strategies necessary for accelerated growth are given and countries with potential for a significant increase in annual PV installation rates are identified. The current main constraint on market growth is the global shortage of suitable silicon, but confidence in the solar market is now sufficient for significant new manufacturing plant to be planned. Investment in other PV technologies is also required, plus a decrease in the price of PV modules. EPIA does not expect a short-term price reduction for PV until after 2007 but the workshop concluded that the PV industry could expect to see an average price reduction of around 5% per year (for cells, modules and complete systems) by 2011

  6. Prospect of Cattle Development to Support Self Sufficiency of Meat in North Sumatera Province

    Directory of Open Access Journals (Sweden)

    Akhmad Rifai Lubis

    2010-06-01

    Full Text Available Shortage of beef supply to meet national needs is also found locally in North Sumatera Province. The trend for beef in this area was triggered by the increasing of population, economic improvement and desire for better nutrient comsumption. Level of beef consumption is increased 17% from year 2004 to 2008, so in the same period the number of cattle entered into the North Sumatera Province also increased. Some efforts had been conducted to develop beef cattle program in North Sumatera Self Sufficiency Program in Beef through technical and policy approaches. Several programs have been developed to accelerate the development of productivity and the population in North Sumatra, among others, 1 Agribusiness Development Program, 2 Food Security Improvement Program, 3 Farmer's Welfare Program; which are financed by both central and local budgets. Institutional aspects that have been developed to support the PSDS-2014 is the Regional Artificial Insemination Center to serve the needs of semen for districts and municipalities in the Province of North Sumatera. In the year 2008, it has been distributed as many as 44 000 doses of semen for frozen semen to meet the demands of 11 Districts. The amount of land resources for development indicated the availability of pastural land area of 1,311,159 ha from oil palm and rubber plantation, area of 1,192,172 ha for crops and livestock integration system. It is estimated that biomass production of rice straw, bean straw and sugarcane straw reaches 7,062,227; 68 145 and 14 664 tons per year, respectively. Also available as many as 689,478 tons of rice bran and palm oil industry waste as much as 4,159,203 tons per year. Some challenges in the North Sumatera PSDS programs in accordance with a predetermined time include: 1 Not all of the stakeholders get a complete information about the program, 2 the difficulties to prevent productive cows being slaughtered, 3 limited capital in an effort to pick up and redistribute

  7. Sufficient vitamin K status combined with sufficient vitamin D status is associated with better lower extremity function: a prospective analysis of two knee osteoarthritis cohorts.

    Science.gov (United States)

    Shea, M Kyla; Loeser, Richard F; McAlindon, Timothy E; Houston, Denise K; Kritchevsky, Stephen B; Booth, Sarah L

    2017-10-17

    Vitamins K and D are important for the function of vitamin K-dependent proteins in joint tissues. It is unclear if these nutrients are mutually important to functional outcomes related to knee osteoarthritis (OA). We evaluated the association of vitamin K and D sufficiency with lower-extremity function in the Health, Aging Body Composition Knee OA Sub-study (Health ABC) and conducted a replication analysis in an independent cohort, the Osteoarthritis Initiative (OAI). In Health ABC (60% female, 75±3 years) baseline nutrient status was measured using circulating vitamin K and 25(OH)D. Lower-extremity function was assessed using the short physical performance battery (SPPB) and usual 20-meter gait speed. In the OAI (58% female, 61±9 years), baseline nutrient intake was estimated by food frequency questionnaire. Lower-extremity function was assessed using usual 20-meter gait speed and chair stand completion time. Multivariate mixed models were used to evaluate the association of vitamin K and D status and intake with lower-extremity function over 4-5 years. Health ABC participants with sufficient plasma vitamin K (≥1.0 nmol/L) and serum 25(OH)D (≥50 nmol/L) generally had better SPPB scores and faster usual gait speed over follow-up (p≤0.002). In the OAI, sufficient vitamin K and vitamin D intake combined was associated with overall faster usual gait speed and chair stand completion time over follow-up (p≤0.029). Sufficient vitamin K status combined with sufficient vitamin D status was associated with better lower-extremity function in two knee OA cohorts. These findings merit confirmation in vitamin K and D co-supplementation trials. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  8. Usefulness of the jump-and-reach test in assessment of vertical jump performance.

    Science.gov (United States)

    Menzel, Hans-Joachim; Chagas, Mauro H; Szmuchrowski, Leszek A; Araujo, Silvia R; Campos, Carlos E; Giannetti, Marcus R

    2010-02-01

    The objective was to estimate the reliability and criterion-related validity of the Jump-and-Reach Test for the assessment of squat, countermovement, and drop jump performance of 32 male Brazilian professional volleyball players. Performance of squat, countermovement, and drop jumps with different dropping heights was assessed on the Jump-and-Reach Test and the measurement of flight time, then compared across different jump trials. The very high reliability coefficients of both assessment methods and the lower correlation coefficients between scores on the assessments indicate a very high consistency of each method but only moderate covariation, which means that they measure partly different items. As a consequence, the Jump-and-Reach Test has good ecological validity in situations when reaching height during the flight phase is critical for performance (e.g., basketball and volleyball) but only limited accuracy for the assessment of vertical impulse production with different jump techniques and conditions.

  9. Naturalness Reach of the Large Hadron Collider in Minimal Supergravity

    CERN Document Server

    Allanach, B.C.; Parker, Michael Andrew; Webber, B.R.

    2000-01-01

    We re-analyse the prospects of discovering supersymmetry at the LHC, in order to re-express coverage in terms of a fine-tuning parameter and to extend the analysis to scalar masses (m_0) above 2 TeV. We use minimal supergravity (mSUGRA) unification assumptions for the SUSY breaking parameters. Such high values of m_0 have recently been found to have a focus point, leading to relatively low fine-tuning. In addition, improvements in the simulations since the last study mean that this region no longer lacks radiative electroweak symmetry breaking. The best fine tuning reach is found in a mono-leptonic channel, where for mu>0, A_0=0 and tan beta=10 (corresponding to the focus point), all points in mSUGRA with m_0 < 4000 GeV, with a fine tuning measure up to 300 (570) are covered by the search, where the definition of fine-tuning excludes (includes) the contribution from the top Yukawa coupling. Even for arbitrarily high m_0, mSUGRA does not evade detection provided the gaugino mass parameter M_{1/2} < 460 G...

  10. Impulsivity modulates performance under response uncertainty in a reaching task.

    Science.gov (United States)

    Tzagarakis, C; Pellizzer, G; Rogers, R D

    2013-03-01

    We sought to explore the interaction of the impulsivity trait with response uncertainty. To this end, we used a reaching task (Pellizzer and Hedges in Exp Brain Res 150:276-289, 2003) where a motor response direction was cued at different levels of uncertainty (1 cue, i.e., no uncertainty, 2 cues or 3 cues). Data from 95 healthy adults (54 F, 41 M) were analysed. Impulsivity was measured using the Barratt Impulsiveness Scale version 11 (BIS-11). Behavioral variables recorded were reaction time (RT), errors of commission (referred to as 'early errors') and errors of precision. Data analysis employed generalised linear mixed models and generalised additive mixed models. For the early errors, there was an interaction of impulsivity with uncertainty and gender, with increased errors for high impulsivity in the one-cue condition for women and the three-cue condition for men. There was no effect of impulsivity on precision errors or RT. However, the analysis of the effect of RT and impulsivity on precision errors showed a different pattern for high versus low impulsives in the high uncertainty (3 cue) condition. In addition, there was a significant early error speed-accuracy trade-off for women, primarily in low uncertainty and a 'reverse' speed-accuracy trade-off for men in high uncertainty. These results extend those of past studies of impulsivity which help define it as a behavioural trait that modulates speed versus accuracy response styles depending on environmental constraints and highlight once more the importance of gender in the interplay of personality and behaviour.

  11. Should these potential CMR substances have been registered under REACH?

    DEFF Research Database (Denmark)

    Wedebye, Eva Bay; Nikolov, Nikolai Georgiev; Dybdahl, Marianne

    2013-01-01

    (Q)SAR models were applied to screen around 68,000 REACH pre-registered substances for CMR properties (carcinogenic, mutagenic or toxic to reproduction). Predictions from 14 relevant models were combined to reach overall calls for C, M and R. Combining predictions may reduce “noise” and increase...

  12. An energy self-sufficient public building using integrated renewable sources and hydrogen storage

    International Nuclear Information System (INIS)

    Marino, C.; Nucara, A.; Pietrafesa, M.; Pudano, A.

    2013-01-01

    The control of the use of fossil fuels, major cause of greenhouse gas emissions and climate changes, in present days represents one of Governments' main challenges; particularly, a significant energy consumption is observed in buildings and might be significantly reduced through sustainable design, increased energy efficiency and use of renewable sources. At the moment, the widespread use of renewable energy in buildings is limited by its intrinsic discontinuity: consequently integration of plants with energy storage systems could represent an efficient solution to the problem. Within this frame, hydrogen has shown to be particularly fit in order to be used as an energetic carrier. In this aim, in the paper an energetic, economic and environmental analysis of two different configurations of a self-sufficient system for energy production from renewable sources in buildings is presented. In particular, in the first configuration energy production is carried out by means of photovoltaic systems, whereas in the second one a combination of photovoltaic panels and wind generators is used. In both configurations, hydrogen is used as an energy carrier, in order to store energy, and fuel cells guarantee its energetic reconversion. The analysis carried out shows that, although dimensioned as a stand-alone configuration, the system can today be realized only taking advantage from the incentivizing fares applied to grid-connected systems, that are likely to be suspended in the next future. In such case, it represents an interesting investment, with capital returns in about 15 years. As concerns economic sustainability, in fact, the analysis shows that the cost of the energy unit stored in hydrogen volumes, due to the not very high efficiency of the process, presently results greater than that of directly used one. Moreover, also the starting fund of the system proves to be very high, showing an additional cost with respect to systems lacking of energy storage equal to about 50

  13. Enough is as good as a feast - sufficiency as policy. Volume 1

    International Nuclear Information System (INIS)

    Darby, Sarah

    2007-01-01

    The concept of sufficiency has a long history, related as it is to the timeless issues of how best to distribute and use resources. Where energy is concerned, absolute reductions in demand are increasingly seen as necessary in response to climate change and energy security concerns. There is an acknowledgement that, collectively if not individually, humans have gone beyond safe limits in their use of fuels. The relatively wealthy and industrialised nations urgently need to move beyond a primary focus on efficiency to the more contentious issues surrounding demand reduction and sufficiency. The paper considers definitions of energy sufficiency, looks at a recent attempt to model future energy use in terms of efficiency and sufficiency, and discusses quantitative and qualitative aspects of sufficiency and how they might become institutionalised. There are many arguments in favour of sufficiency but they often founder in the face of political requirements for market growth and the employment generated by it. Some options for 'sufficiency policy' are selected, including a focus on energy in relation to livelihoods, energy implications of our use of time and making energy use more transparent

  14. Enough is as good as a feast - sufficiency as policy. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Darby, Sarah [Lower Carbon Futures, Environmental Change Inst., Oxford Univ. Centre for the Environment (United Kingdom)

    2007-07-01

    The concept of sufficiency has a long history, related as it is to the timeless issues of how best to distribute and use resources. Where energy is concerned, absolute reductions in demand are increasingly seen as necessary in response to climate change and energy security concerns. There is an acknowledgement that, collectively if not individually, humans have gone beyond safe limits in their use of fuels. The relatively wealthy and industrialised nations urgently need to move beyond a primary focus on efficiency to the more contentious issues surrounding demand reduction and sufficiency. The paper considers definitions of energy sufficiency, looks at a recent attempt to model future energy use in terms of efficiency and sufficiency, and discusses quantitative and qualitative aspects of sufficiency and how they might become institutionalised. There are many arguments in favour of sufficiency but they often founder in the face of political requirements for market growth and the employment generated by it. Some options for 'sufficiency policy' are selected, including a focus on energy in relation to livelihoods, energy implications of our use of time and making energy use more transparent.

  15. Nueva política europea en productos químicos. REACH New European policy on chemical products. REACH

    Directory of Open Access Journals (Sweden)

    Francisco Vargas Marcos

    2005-12-01

    Regulation concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH. This proposal creates a European Chemicals Agency and establishes the REACH system with the following elements:Registration requires industry to obtain relevant information on their substances and to use data to manage them safely.Evaluation provides confidence that industry is meeting its obligations and prevents unnecessary testing.Authorisation of substances with properties of very high concern (CMRs, PBTs, endocrine disrupters for particular uses.Restriction as a safety net to manage risks that have not been addressed previously in the system.This system will provide information in several phases in order to know and reduce the risks derived from use of around 30,000 chemical substances that are manufactured/imported in the European Union in quantities over one ton per year. The information will be saved in a database after validation and may be used to establish a causal relationship between the environmental factors and the negative effects on health associated to the production and use of chemical products.

  16. Complex hydro- and sediment dynamics survey of two critical reaches on the Hungarian part of river Danube

    International Nuclear Information System (INIS)

    Baranya, Sandor; Jozsa, Janos; Goda, Laszlo; Rakoczi, Laszlo

    2008-01-01

    Detailed hydrodynamic survey of two critical river reaches has been performed from hydro- and sediment dynamics points of view, in order to explore the main features, moreover, provide calibration and verification data to related 3D flow and sediment transport modelling. Special attention has been paid to compare moving and fix boat measurement modes for estimating various flow and large-scale bed form features, resulting in recommendations e.g. on the time period needed in stationary mode operation to obtain sufficiently stabilized average velocity profiles and related parameter estimations. As to the study reaches, the first comprises a 5 km long sandy-gravel bed reach of river Danube located in Central-Hungary, presenting problems for navigation. As a conventional remedy, groyne fields have been implemented to make and maintain the reach sufficiently deep, navigable even in low flow periods. As is usually the case, these works resulted in rather complex flow characteristics and related bed topography at places. The second site is another 5 km long reach of river Danube, close to the southern border to Serbia. There the river presents navigational problems similar to the previously mentioned reach, however, having entirely sand bed conditions, abundant in a variety of dunes, especially in the shallower parts. In both study reaches ADCP measurements were done with around 2.5 Hz sampling frequency both in moving boat operation mode providing overall, though locally moderately representative picture, and in fixed boat mode at a considerable number of selected verticals with 10 minutes long measuring time.

  17. An investigation of the neural circuits underlying reaching and reach-to-grasp movements: from planning to execution.

    Directory of Open Access Journals (Sweden)

    Chiara eBegliomini

    2014-09-01

    Full Text Available Experimental evidence suggests the existence of a sophisticated brain circuit specifically dedicated to reach-to-grasp planning and execution, both in human and non human primates (Castiello, 2005. Studies accomplished by means of neuroimaging techniques suggest the hypothesis of a dichotomy between a reach-to-grasp circuit, involving the intraparietal area (AIP, the dorsal and ventral premotor cortices (PMd and PMv - Castiello and Begliomini, 2008; Filimon, 2010 and a reaching circuit involving the medial intraparietal area (mIP and the Superior Parieto-Occipital Cortex (SPOC (Culham et al., 2006. However, the time course characterizing the involvement of these regions during the planning and execution of these two types of movements has yet to be delineated. A functional magnetic resonance imaging (fMRI study has been conducted, including reach-to grasp and reaching only movements, performed towards either a small or a large stimulus, and Finite Impulse Response model (FIR - Henson, 2003 was adopted to monitor activation patterns from stimulus onset for a time window of 10 seconds duration. Data analysis focused on brain regions belonging either to the reaching or to the grasping network, as suggested by Castiello & Begliomini (2008.Results suggest that reaching and grasping movements planning and execution might share a common brain network, providing further confirmation to the idea that the neural underpinnings of reaching and grasping may overlap in both spatial and temporal terms (Verhagen et al., 2013.

  18. Breakthrough Capability for UVOIR Space Astronomy: Reaching the Darkest Sky

    Science.gov (United States)

    Greenhouse, Matthew A.; Benson, Scott W.; Englander, Jacob; Falck, Robert D.; Fixsen, Dale J.; Gardner, Jonathan P.; Kruk, Jeffery W.; Oleson, Steven R.; Thronson, Harley A.

    2015-01-01

    We describe how availability of new solar electric propulsion (SEP) technology can substantially increase the science capability of space astronomy missions working within the near-UV to far-infrared (UVOIR) spectrum by making dark sky orbits accessible for the first time. We present two case studies in which SEP is used to enable a 700 kg Explorer-class and 7000 kg flagship-class observatory payload to reach an orbit beyond where the zodiacal dust limits observatory sensitivity. The resulting scientific performance advantage relative to a Sun-Earth L2 point (SEL2) orbit is presented and discussed. We find that making SEP available to astrophysics Explorers can enable this small payload program to rival the science performance of much larger long development-time systems. Similarly, we find that astrophysics utilization of high power SEP being developed for the Asteroid Redirect Robotics Mission (ARRM) can have a substantial impact on the sensitivity performance of heavier flagship-class astrophysics payloads such as the UVOIR successor to the James Webb Space Telescope.

  19. Parametric design studies of long-reach manipulators

    International Nuclear Information System (INIS)

    Kwon, D.S.; March-Leuba, S.; Babcock, S.M.; Burks, B.L.; Hamel, W.R.

    1993-01-01

    A number of different approaches have been studied for remediation of waste storage tanks at various sites. One of the most promising approaches is the use of a high-capacity, long-reach manipulation (LRM) system with a variety of end effectors for dislodging the waste. LRMs may have characteristics significantly different from those of industrial robots due to the long links needed to cover the large workspace. Because link lengths are much greater than their diameters, link flexibility, as well as joint or drive train flexibility, is likely to be significant. LRMs will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional, kinematic, and performance requirements, a design approach for determining the kinematic applicability and performance characteristics considering link flexibility is presented with a focus on waste storage tank remediation. This paper addresses key design issues for LRM-based waste retrieval systems. It discusses the effects of parameters such as payload capacity, storage tanks size, and access port diameter on manipulator structural design. The estimated weight, fundamental natural frequency, and static deflection of the manipulator have been calculated for various parameter conditions

  20. Real-time well condition monitoring in extended reach wells

    Energy Technology Data Exchange (ETDEWEB)

    Kucs, R.; Spoerker, H.F. [OMV Austria Exploration and Production GmbH, Gaenserndorf (Austria); Thonhauser, G. [Montanuniversitaet Leoben (Austria)

    2008-10-23

    Ever rising daily operating cost for offshore operations make the risk of running into drilling problems due to torque and drag developments in extended reach applications a growing concern. One option to reduce cost related to torque and drag problems can be to monitor torque and drag trends in real time without additional workload on the platform drilling team. To evaluate observed torque or drag trends it is necessary to automatically recognize operations and to have a 'standard value' to compare the measurements to. The presented systematic approach features both options - fully automated operations recognition and real time analysis. Trends can be discussed between rig- and shore-based teams, and decisions can be based on up to date information. Since the system is focused on visualization of real-time torque and drag trends, instead of highly complex and repeated simulations, calculation time is reduced by comparing the real-time rig data against predictions imported from a commercial drilling engineering application. The system allows reacting to emerging stuck pipe situations or developing cuttings beds long before the situations become severe enough to result in substantial lost time. The ability to compare real-time data with historical data from the same or other wells makes the system a valuable tool in supporting a learning organization. The system has been developed in a joint research initiative for field application on the development of an offshore heavy oil field in New Zealand. (orig.)

  1. Muscle synergy extraction during arm reaching movements at different speeds.

    Science.gov (United States)

    Sabzevari, Vahid Reza; Jafari, Amir Homayoun; Boostani, Reza

    2017-01-01

    Muscle synergy is the activation of a group of muscles that contribute to a particular movement. The goal of the present study is to examine the hypothesis that human reaching movements at different speeds share similar muscle synergies and to investigate the kinesiology basis and innervation of muscles. Electromyographic activity from six muscles of the upper limb and shoulder girdle were recorded during three movements at different speeds, i.e. slow, moderate and fast. The effect of window length on the RMS signal of the EMG was analyzed and then EMG envelope signals were decomposed using non-negative matrix factorization. For each of the ten subjects, three synergies were extracted which accounted for at least 99% of the VAF. For each movement, the muscle synergies and muscle activation coefficients of all participants were clustered in to three partitions. Investigation showed a high similarity and dependency of cluster members due to the cosine similarity and mutual information in muscle synergy clustering. For further verification, the EMG envelope signals for all subjects were reconstructed. The results indicated a lower reconstruction error using the center of the muscle synergy clusters in comparison with the average of the activation coefficients, which confirms the current research's hypothesis.

  2. Are world uranium resources sufficient to fuel global growth in nuclear generating capacity?

    International Nuclear Information System (INIS)

    Cameron, R.; Vance, R.E.

    2012-01-01

    Increased uranium prices since 2003 have produced more activity in the sector than the previous 20 years. Nuclear reactor construction is proceeding in some countries, ambitious expansion plans have been announced in others and several, particularly in the developing world, are considering introducing nuclear power as a means of meeting rising electricity demand without increasing greenhouse gas emissions. Others have recently decided to either withdraw from the use of nuclear power or not proceed with development plans following the accident at the Fukushima Dai-ichi nuclear power plant in Japan in March 2011. Since the mid-1960, the OECD Nuclear Energy Agency and the International Atomic Energy Agency have jointly prepared a comprehensive update of global uranium resources, production and demand (commonly known as the 'Red Book'. The Red Book is based on government responses to a questionnaire that requests information on uranium exploration and mine development activity, resources and plans for nuclear development to 2035. This presentation provides an overview of the global situation based on the recently published 2011 edition. It features a compilation of global uranium resources, projected mine development and production capability in all the countries currently producing uranium or with plans to do so in the near future. This is compared to updated, post-Fukushima demand projections, reflecting nuclear phase-out plans announced in some countries and ambitious expansion plans of others. The 2011 Red Book shows that currently defined uranium resources are sufficient to meet high case projections of nuclear power development to 2035. (authors)

  3. Necessary and sufficient conditions for big bangs, bounces, crunches, rips, sudden singularities and extremality events

    International Nuclear Information System (INIS)

    Cattoen, Celine; Visser, Matt

    2005-01-01

    Until recently, the physically relevant singularities occurring in FRW cosmologies had traditionally been thought to be limited to the 'big bang', and possibly a 'big crunch'. However, over the last few years, the zoo of cosmological singularities considered in the literature has become considerably more extensive, with 'big rips' and 'sudden singularities' added to the mix, as well as renewed interest in nonsingular cosmological events such as 'bounces' and 'turnarounds'. In this paper we present an extensive catalogue of such cosmological milestones, both at the kinematical and dynamical level. First, using generalized power series, purely kinematical definitions of these cosmological events are provided in terms of the behaviour of the scale factor a(t). The notion of a 'scale-factor singularity' is defined, and its relation to curvature singularities (polynomial and differential) is explored. Second, dynamical information is extracted by using the Friedmann equations (without assuming even the existence of any equation of state) to place constraints on whether or not the classical energy conditions are satisfied at the cosmological milestones. We use these considerations to derive necessary and sufficient conditions for the existence of cosmological milestones such as bangs, bounces, crunches, rips, sudden singularities and extremality events. Since the classification is extremely general and, modulo certain technical assumptions, is complete, the corresponding results are to a high degree model independent: in particular, we provide a characterization of the class of bangs, crunches and sudden singularities for which the dominant energy condition is satisfied

  4. Networks of conforming or nonconforming individuals tend to reach satisfactory decisions.

    Science.gov (United States)

    Ramazi, Pouria; Riehl, James; Cao, Ming

    2016-11-15

    Binary decisions of agents coupled in networks can often be classified into two types: "coordination," where an agent takes an action if enough neighbors are using that action, as in the spread of social norms, innovations, and viral epidemics, and "anticoordination," where too many neighbors taking a particular action causes an agent to take the opposite action, as in traffic congestion, crowd dispersion, and division of labor. Both of these cases can be modeled using linear-threshold-based dynamics, and a fundamental question is whether the individuals in such networks are likely to reach decisions with which they are satisfied. We show that, in the coordination case, and perhaps more surprisingly, also in the anticoordination case, the agents will indeed always tend to reach satisfactory decisions, that is, the network will almost surely reach an equilibrium state. This holds for every network topology and every distribution of thresholds, for both asynchronous and partially synchronous decision-making updates. These results reveal that irregular network topology, population heterogeneity, and partial synchrony are not sufficient to cause cycles or nonconvergence in linear-threshold dynamics; rather, other factors such as imitation or the coexistence of coordinating and anticoordinating agents must play a role.

  5. Reach of the Fermilab Tevatron and CERN LHC for gaugino mediated SUSY breaking models

    International Nuclear Information System (INIS)

    Baer, Howard; Belyaev, Alexander; Krupovnickas, Tadas; Tata, Xerxes

    2002-01-01

    In supersymmetric models with gaugino mediated SUSY breaking (gMSB), it is assumed that SUSY breaking on a hidden brane is communicated to the visible brane via gauge superfields which propagate in the bulk. This leads to GUT models where the common gaugino mass m 1/2 is the only soft SUSY breaking term to receive contributions at the tree level. To obtain a viable phenomenology, it is assumed that the gaugino mass is induced at some scale M c beyond the GUT scale, and that additional renormalization group running takes place between M c and M GUT as in a SUSY GUT. We assume an SU(5) SUSY GUT above the GUT scale, and compute the SUSY particle spectrum expected in models with gMSB. We use the Monte Carlo program ISAJET to simulate signals within the gMSB model, and compute the SUSY reach including cuts and triggers appropriate to Fermilab Tevatron and CERN LHC experiments. We find no reach for SUSY by the Tevatron collider in the trilepton channel. At the CERN LHC, values of m 1/2 =1000 (1160) GeV can be probed with 10 (100) fb -1 of integrated luminosity, corresponding to a reach in terms of m g-tilde of 2150 (2500) GeV. The gMSB model and MSUGRA can likely only be differentiated at a linear e + e - collider with sufficient energy to produce sleptons and charginos

  6. The coordination patterns observed when two hands reach-to-grasp separate objects.

    Science.gov (United States)

    Bingham, Geoffrey P; Hughes, Kirstie; Mon-Williams, Mark

    2008-01-01

    What determines coordination patterns when both hands reach to grasp separate objects at the same time? It is known that synchronous timing is preferred as the most stable mode of bimanual coordination. Nonetheless, normal unimanual prehension behaviour predicts asynchrony when the two hands reach towards unequal targets, with synchrony restricted to targets equal in size and distance. Additionally, sufficiently separated targets require sequential looking. Does synchrony occur in all cases because it is preferred in bimanual coordination or does asynchrony occur because of unimanual task constraints and the need for sequential looking? We investigated coordinative timing when participants (n = 8) moved their right (preferred) hand to the same object at a fixed distance but the left hand to objects of different width (3, 5, and 7 cm) and grip surface size (1, 2, and 3 cm) placed at different distances (20, 30, and 40 cm) over 270 randomised trials. The hand movements consisted of two components: (1) an initial component (IC) during which the hand reached towards the target while forming an appropriate grip aperture, stopping at (but not touching) the object; (2) a completion component (CC) during which the finger and thumb closed on the target. The two limbs started the IC together but did not interact until the deceleration phase when evidence of synchronisation began to appear. Nonetheless, asynchronous timing was present at the end of the IC and preserved through the CC even with equidistant targets. Thus, there was synchrony but requirements for visual information ultimately yielded asynchronous coordinative timing.

  7. A brief intervention is sufficient for many adolescents seeking help from low threshold adolescent psychiatric services

    Directory of Open Access Journals (Sweden)

    Laukkanen Eila

    2010-09-01

    Full Text Available Abstract Background There has been a considerable increase in the need for psychiatric services for adolescents. Primary health care practitioners have a major role in detecting, screening and helping these adolescents. An intervention entitled SCREEN is described in this article. The SCREEN intervention was developed to help practitioners to detect and screen adolescent needs, to care for adolescents at the primary health care level and to facilitate the referral of adolescents to secondary care services in collaboration between primary and secondary health care. Secondly, the article presents the background and clinical characteristics of youths seeking help from the SCREEN services, and compares the background factors and clinical characteristics of those patients referred and not referred to secondary care services. Methods The SCREEN intervention consisted of 1 to 5 sessions, including assessment by a semi-structured anamnesis interview, the structured Global Assessment Scale, and by a structured priority rating scale, as well as a brief intervention for each adolescent's chosen problem. Parents took part in the assessment in 39% of cases involving girls and 50% involving boys. During 34 months, 2071 adolescents (69% females entered the intervention and 70% completed it. The mean age was 17.1 years for boys and 17.3 years for girls. Results For 69% of adolescents, this was the first contact with psychiatric services. The most common reasons for seeking services were depressive symptoms (31%. Self-harming behaviour had occurred in 25% of girls and 16% of boys. The intervention was sufficient for 37% of those who completed it. Psychosocial functioning improved during the intervention. Factors associated with referral for further treatment were female gender, anxiety as the main complaint, previous psychiatric treatment, self-harming behaviour, a previous need for child welfare services, poor psychosocial functioning and a high score in the

  8. Proximal and distal adjustments of reaching behavior in preterm infants.

    Science.gov (United States)

    de Toledo, Aline Martins; Soares, Daniele de Almeida; Tudella, Eloisa

    2011-01-01

    The authors aimed to investigate proximal and distal adjustments of reaching behavior and grasping in 5-, 6-, and 7-month-old preterm infants. Nine low-risk preterm and 10 full-term infants participated. Both groups showed the predominance of unimanual reaching, an age-related increase in the frequency of vertical-oriented and open hand movement, and also an increase in successful grasping from 6 to 7 months. The frequency of open hand was higher in the preterm group at 6 months. Intrinsic restrictions imposed by prematurity did not seem to have impaired reaching performance of preterm infants throughout the months of age.

  9. Emergent coordination underlying learning to reach to grasp with a brain-machine interface.

    Science.gov (United States)

    Vaidya, Mukta; Balasubramanian, Karthikeyan; Southerland, Joshua; Badreldin, Islam; Eleryan, Ahmed; Shattuck, Kelsey; Gururangan, Suchin; Slutzky, Marc; Osborne, Leslie; Fagg, Andrew; Oweiss, Karim; Hatsopoulos, Nicholas G

    2018-04-01

    The development of coordinated reach-to-grasp movement has been well studied in infants and children. However, the role of motor cortex during this development is unclear because it is difficult to study in humans. We took the approach of using a brain-machine interface (BMI) paradigm in rhesus macaques with prior therapeutic amputations to examine the emergence of novel, coordinated reach to grasp. Previous research has shown that after amputation, the cortical area previously involved in the control of the lost limb undergoes reorganization, but prior BMI work has largely relied on finding neurons that already encode specific movement-related information. In this study, we taught macaques to cortically control a robotic arm and hand through operant conditioning, using neurons that were not explicitly reach or grasp related. Over the course of training, stereotypical patterns emerged and stabilized in the cross-covariance between the reaching and grasping velocity profiles, between pairs of neurons involved in controlling reach and grasp, and to a comparable, but lesser, extent between other stable neurons in the network. In fact, we found evidence of this structured coordination between pairs composed of all combinations of neurons decoding reach or grasp and other stable neurons in the network. The degree of and participation in coordination was highly correlated across all pair types. Our approach provides a unique model for studying the development of novel, coordinated reach-to-grasp movement at the behavioral and cortical levels. NEW & NOTEWORTHY Given that motor cortex undergoes reorganization after amputation, our work focuses on training nonhuman primates with chronic amputations to use neurons that are not reach or grasp related to control a robotic arm to reach to grasp through the use of operant conditioning, mimicking early development. We studied the development of a novel, coordinated behavior at the behavioral and cortical level, and the neural

  10. A necessary and sufficient condition for a real quadratic extension to have class number one

    International Nuclear Information System (INIS)

    Alemu, Y.

    1990-02-01

    We give a necessary and sufficient condition for a real quadratic extension to have class number one and discuss the applicability of the result to find the class number one fields with small discriminant. 9 refs, 3 tabs

  11. The Effects of Simple Necessity and Sufficiency Relationships on Children's Causal Inferences

    Science.gov (United States)

    Siegler, Robert S.

    1976-01-01

    Attempted to determine (1) whether developmental differences existed in children's comprehension of simple necessity and simple sufficiency relationships, and (2) the source of developmental differences in children's causal reasoning. (SB)

  12. Sufficient conditions for positivity of non-Markovian master equations with Hermitian generators

    International Nuclear Information System (INIS)

    Wilkie, Joshua; Wong Yinmei

    2009-01-01

    We use basic physical motivations to develop sufficient conditions for positive semidefiniteness of the reduced density matrix for generalized non-Markovian integrodifferential Lindblad-Kossakowski master equations with Hermitian generators. We show that it is sufficient for the memory function to be the Fourier transform of a real positive symmetric frequency density function with certain properties. These requirements are physically motivated, and are more general and more easily checked than previously stated sufficient conditions. We also explore the decoherence dynamics numerically for some simple models using the Hadamard representation of the propagator. We show that the sufficient conditions are not necessary conditions. We also show that models exist in which the long time limit is in part determined by non-Markovian effects

  13. Countrywide Evaluation of the Long-Term Family Self-Sufficiency Plan. Establishing the Baselines

    National Research Council Canada - National Science Library

    Schoeni, Robert

    2002-01-01

    ...) Plan on November 16,1999. The LTFSS Plan consists of 46 projects whose goal is to promote self-sufficiency among families that are participating in the California Work Opportunity and Responsibility to Kids (CalWORKs...

  14. Impact of Market Behavior, Fleet Composition, and Ancillary Services on Revenue Sufficiency

    Energy Technology Data Exchange (ETDEWEB)

    Frew, Bethany

    2016-04-26

    This presentation provides an overview of new and ongoing NREL research that aims to improve our understanding of reliability and revenue sufficiency challenges through modeling tools within a markets framework.

  15. 76 FR 39115 - Notice of Proposed Information Collection: Transformation Initiative Family Self-Sufficiency...

    Science.gov (United States)

    2011-07-05

    ... Information Collection: Transformation Initiative Family Self-Sufficiency Demonstration Small Grants AGENCY... information: Title of Proposal: Notice of Funding Availability for the Transformation Initiative Family Self..., think tanks, consortia, Institutions of higher education accredited by a national or regional...

  16. Peer Support for the Hardly Reached: A Systematic Review.

    Science.gov (United States)

    Sokol, Rebeccah; Fisher, Edwin

    2016-07-01

    Health disparities are aggravated when prevention and care initiatives fail to reach those they are intended to help. Groups can be classified as hardly reached according to a variety of circumstances that fall into 3 domains: individual (e.g., psychological factors), demographic (e.g., socioeconomic status), and cultural-environmental (e.g., social network). Several reports have indicated that peer support is an effective means of reaching hardly reached individuals. However, no review has explored peer support effectiveness in relation to the circumstances associated with being hardly reached or across diverse health problems. To conduct a systematic review assessing the reach and effectiveness of peer support among hardly reached individuals, as well as peer support strategies used. Three systematic searches conducted in PubMed identified studies that evaluated peer support programs among hardly reached individuals. In aggregate, the searches covered articles published from 2000 to 2015. Eligible interventions provided ongoing support for complex health behaviors, including prioritization of hardly reached populations, assistance in applying behavior change plans, and social-emotional support directed toward disease management or quality of life. Studies were excluded if they addressed temporally isolated behaviors, were limited to protocol group classes, included peer support as the dependent variable, did not include statistical tests of significance, or incorporated comparison conditions that provided appreciable social support. We abstracted data regarding the primary health topic, categorizations of hardly reached groups, program reach, outcomes, and strategies employed. We conducted a 2-sample t test to determine whether reported strategies were related to reach. Forty-seven studies met our inclusion criteria, and these studies represented each of the 3 domains of circumstances assessed (individual, demographic, and cultural-environmental). Interventions

  17. Neurons in Primary Motor Cortex Encode Hand Orientation in a Reach-to-Grasp Task.

    Science.gov (United States)

    Ma, Chaolin; Ma, Xuan; Fan, Jing; He, Jiping

    2017-08-01

    It is disputed whether those neurons in the primary motor cortex (M1) that encode hand orientation constitute an independent channel for orientation control in reach-to-grasp behaviors. Here, we trained two monkeys to reach forward and grasp objects positioned in the frontal plane at different orientation angles, and simultaneously recorded the activity of M1 neurons. Among the 2235 neurons recorded in M1, we found that 18.7% had a high correlation exclusively with hand orientation, 15.9% with movement direction, and 29.5% with both movement direction and hand orientation. The distributions of neurons encoding hand orientation and those encoding movement direction were not uniform but coexisted in the same region. The trajectory of hand rotation was reproduced by the firing patterns of the orientation-related neurons independent of the hand reaching direction. These results suggest that hand orientation is an independent component for the control of reaching and grasping activity.

  18. Transforming the energy system: Why municipalities strive for energy self-sufficiency

    International Nuclear Information System (INIS)

    Engelken, Maximilian; Römer, Benedikt; Drescher, Marcus; Welpe, Isabell

    2016-01-01

    Despite evidence that a rising number of municipalities in Germany are striving for energy self-sufficiency, there is little understanding of the driving factors behind this development. We investigate economic, ecological, social and energy system related factors that drive municipalities to strive for energy self-sufficiency with a focus on electricity supply. The empirical data for this study is based on insights generated through expert interviews (N =19) with mayors, energy experts and scientists as well as a quantitative study among mayors and energy officers (N =109) of German municipalities. Results show that environmental awareness, tax revenues and greater independence from private utilities are positively related to the mayors’ attitude towards the realization of energy self-sufficiency. Furthermore, citizens, the political environment, the mayor's political power, and his/her financial resources are relevant factors for a municipality striving for energy self-sufficiency. Policymakers need to decide whether or not to support mayors in this development. For suitable policy interventions, the results suggest the importance of an integrated approach that considers a combination of identified factors. Finally, we propose a morphological box to structure different aspects of energy self-sufficiency and categorize the present study. - Highlights: • Municipalities striving for energy self-sufficiency can play a key role in the transition of the energy system. • Tax revenues and environmental awareness main drivers behind mayors’ attitude towards energy self-sufficiency. • Citizens and the political environment main influencers of mayors striving for energy self-sufficiency. • 19 expert interviews analyzed for the framework of the study based on the theory of planned behavior (TPB). • 109 mayors and energy officers participated in the quantitative main survey.

  19. Long-Term Resource Adequacy, Long-Term Flexibility Requirements, and Revenue Sufficiency

    Energy Technology Data Exchange (ETDEWEB)

    Milligan, Michael [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Bloom, Aaron P [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Townsend, Aaron [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Ela, Erik [Electric Power Research Institute; Botterud, Audun [Argonne National Laboratory; Levin, Todd [Argonne National Laboratory

    2018-02-15

    Variable generation (VG) can reduce market prices over time and also the energy that other suppliers can sell in the market. The suppliers that are needed to provide capacity and flexibility to meet the long-term reliability requirements may, therefore, earn less revenue. This chapter discusses the topics of resource adequacy and revenue sufficiency - that is, determining and acquiring the quantity of capacity that will be needed at some future date and ensuring that those suppliers that offer the capacity receive sufficient revenue to recover their costs. The focus is on the investment time horizon and the installation of sufficient generation capability. First, the chapter discusses resource adequacy, including newer methods of determining adequacy metrics. The chapter then focuses on revenue sufficiency and how suppliers have sufficient opportunity to recover their total costs. The chapter closes with a description of the mechanisms traditionally adopted by electricity markets to mitigate the issues of resource adequacy and revenue sufficiency and discusses the most recent market design changes to address these issues.

  20. Local tolerance testing under REACH: Accepted non-animal methods are not on equal footing with animal tests.

    Science.gov (United States)

    Sauer, Ursula G; Hill, Erin H; Curren, Rodger D; Raabe, Hans A; Kolle, Susanne N; Teubner, Wera; Mehling, Annette; Landsiedel, Robert

    2016-07-01

    In general, no single non-animal method can cover the complexity of any given animal test. Therefore, fixed sets of in vitro (and in chemico) methods have been combined into testing strategies for skin and eye irritation and skin sensitisation testing, with pre-defined prediction models for substance classification. Many of these methods have been adopted as OECD test guidelines. Various testing strategies have been successfully validated in extensive in-house and inter-laboratory studies, but they have not yet received formal acceptance for substance classification. Therefore, under the European REACH Regulation, data from testing strategies can, in general, only be used in so-called weight-of-evidence approaches. While animal testing data generated under the specific REACH information requirements are per se sufficient, the sufficiency of weight-of-evidence approaches can be questioned under the REACH system, and further animal testing can be required. This constitutes an imbalance between the regulatory acceptance of data from approved non-animal methods and animal tests that is not justified on scientific grounds. To ensure that testing strategies for local tolerance testing truly serve to replace animal testing for the REACH registration 2018 deadline (when the majority of existing chemicals have to be registered), clarity on their regulatory acceptance as complete replacements is urgently required. 2016 FRAME.

  1. Multimodal decoding and congruent sensory information enhance reaching performance in subjects with cervical spinal cord injury

    Directory of Open Access Journals (Sweden)

    Elaine Anna Corbett

    2014-05-01

    Full Text Available Cervical spinal cord injury (SCI paralyzes muscles of the hand and arm, making it difficult to perform activities of daily living. Restoring the ability to reach can dramatically improve quality of life for people with cervical SCI. Any reaching system requires a user interface to decode parameters of an intended reach, such as trajectory and target. A challenge in developing such decoders is that often few physiological signals related to the intended reach remain under voluntary control, especially in patients with high cervical injuries. Furthermore, the decoding problem changes when the user is controlling the motion of their limb, as opposed to an external device. The purpose of this study was to investigate the benefits of combining disparate signal sources to control reach in people with a range of impairments, and to consider the effect of two feedback approaches. Subjects with cervical SCI performed robot-assisted reaching, controlling trajectories with either shoulder electromyograms (EMGs or EMGs combined with gaze. We then evaluated how reaching performance was influenced by task-related sensory feedback, testing the EMG-only decoder in two conditions. The first involved moving the arm with the robot, providing congruent sensory feedback through their remaining sense of proprioception. In the second, the subjects moved the robot without the arm attached, as in applications that control external devices. We found that the multimodal decoding algorithm worked well for all subjects, enabling them to perform straight, accurate reaches. The inclusion of gaze information, used to estimate target location, was especially important for the most impaired subjects. In the absence of gaze information, congruent sensory feedback improved performance. These results highlight the importance of proprioceptive feedback, and suggest that multi-modal decoders are likely to be most beneficial for highly impaired subjects and in tasks where such

  2. PNW River Reach Files -- 1:100k Watercourses (arcs)

    Data.gov (United States)

    Pacific States Marine Fisheries Commission — This feature class includes the ARC features from the 2001 version of the PNW River Reach files Arc/INFO coverage. Separate, companion feature classes are also...

  3. PNW River Reach Files -- 1:100k Waterbodies (polygons)

    Data.gov (United States)

    Pacific States Marine Fisheries Commission — This feature class includes the POLYGON waterbody features from the 2001 version of the PNW River Reach files Arc/INFO coverage. Separate, companion feature classes...

  4. Stream Habitat Reach Summary - North Coast [ds63

    Data.gov (United States)

    California Natural Resource Agency — The shapefile is based on habitat unit level data summarized at the stream reach level. The database represents salmonid stream habitat surveys from 645 streams of...

  5. LTRM Fish Sampling Strata, UMRS La Grange Reach

    Data.gov (United States)

    Department of the Interior — The data set includes delineation of sampling strata for the six study reaches of the UMRR Program’s LTRM element. Separate strata coverages exist for each of the...

  6. LTRM Water Quality Sampling Strata, UMRS La Grange Reach

    Data.gov (United States)

    Department of the Interior — The data set includes delineation of sampling strata for the six study reaches of the UMRR Program’s LTRM element. Separate strata coverages exist for each of the...

  7. A cross-sectional pilot study to examine food sufficiency and assess nutrition among low-income patients with injection-related venous ulcers.

    Science.gov (United States)

    Pieper, Barbara; Templin, Thomas N

    2015-04-01

    Adequate nutrition has long been considered a critical component for wound healing, but literature regarding the relationship between nutrition and venous ulcer (VU) healing is limited. A person's nutrition is affected by the availability of food as well as his/her overall health. Food sufficiency and nutrition are important concerns in the care of persons of low income with injection-related VUs, which tend to be large and slow to heal. A cross-sectional pilot study was conducted to explore the relationship between food sufficiency/security and nutrition with regard to demographic, wound, quality-of-life, physical activity, falls, and fall risk variables. Nutrition was examined using 2 well-developed instruments that measure food sufficiency/security and assess nutrition--the United States Department of Agriculture's Adult Food Sufficiency Questionnaire (FSQ) and the Nestle Mini Nutritional Assessment (MNA). All participants (N = 31, 54% men, mean age 56.1 ± 3.6 years, all African American) were recruited from an outpatient clinic. All had injection-related VUs from a history of injecting illicit substances. In terms of food sufficiency/security, most participants (26, 84%) reported having enough food in the house, but 10 (32%) worried about running out of food. From 16% to 22.6% of participants expressed concern with food sufficiency/security in terms of cutting meal size, eating less, hunger, and weight loss. Food sufficiency/security was high for 19 (61.3%), but 12 (39%) had marginal or lower food sufficiency/security. MNA scores showed 16 participants (52%) were at risk of malnutrition or malnourished. Low food sufficiency/security was significantly (P nutrition assessment scores were significantly associated (P nutrition assessment are important to assess in low-income persons with injection-related VUs. A number of significant relationships of the FSQ and MNA to other variables was found but needs further investigation with a larger sample.

  8. A small antigenic determinant of the Chikungunya virus E2 protein is sufficient to induce neutralizing antibodies which are partially protective in mice.

    Directory of Open Access Journals (Sweden)

    Christopher Weber

    2015-04-01

    Full Text Available The mosquito-borne Chikungunya virus (CHIKV causes high fever and severe joint pain in humans. It is expected to spread in the future to Europe and has recently reached the USA due to globalization, climate change and vector switch. Despite this, little is known about the virus life cycle and, so far, there is no specific treatment or vaccination against Chikungunya infections. We aimed here to identify small antigenic determinants of the CHIKV E2 protein able to induce neutralizing immune responses.E2 enables attachment of the virus to target cells and a humoral immune response against E2 should protect from CHIKV infections. Seven recombinant proteins derived from E2 and consisting of linear and/or structural antigens were created, and were expressed in and purified from E. coli. BALB/c mice were vaccinated with these recombinant proteins and the mouse sera were screened for neutralizing antibodies. Whereas a linear N-terminally exposed peptide (L and surface-exposed parts of the E2 domain A (sA alone did not induce neutralizing antibodies, a construct containing domain B and a part of the β-ribbon (called B+ was sufficient to induce neutralizing antibodies. Furthermore, domain sA fused to B+ (sAB+ induced the highest amount of neutralizing antibodies. Therefore, the construct sAB+ was used to generate a recombinant modified vaccinia virus Ankara (MVA, MVA-CHIKV-sAB+. Mice were vaccinated with MVA-CHIKV-sAB+ and/or the recombinant protein sAB+ and were subsequently challenged with wild-type CHIKV. Whereas four vaccinations with MVA-CHIKV-sAB+ were not sufficient to protect mice from a CHIKV infection, protein vaccination with sAB+ markedly reduced the viral titers of vaccinated mice.The recombinant protein sAB+ contains important structural antigens for a neutralizing antibody response in mice and its formulation with appropriate adjuvants might lead to a future CHIKV vaccine.

  9. Kinesthetically guided reaching accuracy in individuals with a history of traumatic anterior shoulder dislocation

    Directory of Open Access Journals (Sweden)

    Hung Y

    2013-05-01

    Full Text Available You-jou Hung,1 Warren G Darling2 1Doctor of Physical Therapy Program, Department of Nursing and Rehabilitation Sciences, Angelo State University, San Angelo, TX, USA; 2Department of Health and Human Physiology, The University of Iowa, Iowa City, IA, USA Background: The purpose of the study was to investigate whether individuals with a history of traumatic anterior shoulder dislocation show larger reaching errors than those with healthy shoulders and to determine if they implement different reaching strategies to protect the injured shoulder. Methods: Ten people with a history of traumatic anterior shoulder dislocation and 15 with healthy shoulders volunteered for this study. After viewing targets in space, participants pointed with the unconstrained arm to remembered target locations in space without visual guidance. Nine different targets were located in various planes and heights. Endpoint reaching errors were determined by comparing the finger endpoint position without visual guidance to the target location. Shoulder rotation angle at the endpoint was also compared between groups. Results: Participants with injured shoulders were able to point voluntarily to visually specified targets as accurately as participants with healthy shoulders (1 cm difference. However, participants with injured shoulders showed less shoulder external rotation (average 12° difference at the target location when compared with healthy shoulders. This difference was consistent over a large range of target locations. Conclusion: Individuals with a history of traumatic anterior shoulder dislocation have sufficient kinesthetic information about their upper limb orientation to point accurately to visually specified targets in space. However, individuals with injured shoulders acquired a new motor strategy to reach with less shoulder external rotation, presumably to protect the injured shoulder from recurrent injuries. Keywords: shoulder injuries, physiotherapy, shoulder

  10. Memory-guided reaching in a patient with visual hemiagnosia.

    Science.gov (United States)

    Cornelsen, Sonja; Rennig, Johannes; Himmelbach, Marc

    2016-06-01

    The two-visual-systems hypothesis (TVSH) postulates that memory-guided movements rely on intact functions of the ventral stream. Its particular importance for memory-guided actions was initially inferred from behavioral dissociations in the well-known patient DF. Despite of rather accurate reaching and grasping movements to visible targets, she demonstrated grossly impaired memory-guided grasping as much as impaired memory-guided reaching. These dissociations were later complemented by apparently reversed dissociations in patients with dorsal damage and optic ataxia. However, grasping studies in DF and optic ataxia patients differed with respect to the retinotopic position of target objects, questioning the interpretation of the respective findings as a double dissociation. In contrast, the findings for reaching errors in both types of patients came from similar peripheral target presentations. However, new data on brain structural changes and visuomotor deficits in DF also questioned the validity of a double dissociation in reaching. A severe visuospatial short-term memory deficit in DF further questioned the specificity of her memory-guided reaching deficit. Therefore, we compared movement accuracy in visually-guided and memory-guided reaching in a new patient who suffered a confined unilateral damage to the ventral visual system due to stroke. Our results indeed support previous descriptions of memory-guided movements' inaccuracies in DF. Furthermore, our data suggest that recently discovered optic-ataxia like misreaching in DF is most likely caused by her parieto-occipital and not by her ventral stream damage. Finally, multiple visuospatial memory measurements in HWS suggest that inaccuracies in memory-guided reaching tasks in patients with ventral damage cannot be explained by visuospatial short-term memory or perceptual deficits, but by a specific deficit in visuomotor processing. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. Contribution of River Mouth Reach to Sediment Load of the Yangtze River

    Directory of Open Access Journals (Sweden)

    C. Wang

    2015-01-01

    Full Text Available This paper examined the sediment gain and loss in the river mouth reach of the Yangtze River by considering sediment load from the local tributaries, erosion/accretion of the river course, impacts of sand mining, and water extraction. A quantitative estimation of the contribution of the river mouth reach to the sediment load of the Yangtze River was conducted before and after impoundment of the Three Gorges Dam (TGD in 2003. The results showed that a net sediment load loss of 1.78 million ton/yr (Mt/yr occurred from 1965 to 2002 in the study area. The contribution of this reach to the sediment discharge into the sea is not as high as what was expected before the TGD. With impoundment of the TGD, channel deposition (29.90 Mt/yr and a net sediment loss of 30.89 Mt/yr occurred in the river mouth reach from 2003 to 2012. The river mouth reach has acted as a sink but not a source of sediment since impoundment of the TGD, which has exacerbated the decrease in sediment load. Technologies should be advanced to measure changes in river channel morphology, as well as in water and sediment discharges at the river mouth reach.

  12. Role of sufficient statistics in stochastic thermodynamics and its implication to sensory adaptation

    Science.gov (United States)

    Matsumoto, Takumi; Sagawa, Takahiro

    2018-04-01

    A sufficient statistic is a significant concept in statistics, which means a probability variable that has sufficient information required for an inference task. We investigate the roles of sufficient statistics and related quantities in stochastic thermodynamics. Specifically, we prove that for general continuous-time bipartite networks, the existence of a sufficient statistic implies that an informational quantity called the sensory capacity takes the maximum. Since the maximal sensory capacity imposes a constraint that the energetic efficiency cannot exceed one-half, our result implies that the existence of a sufficient statistic is inevitably accompanied by energetic dissipation. We also show that, in a particular parameter region of linear Langevin systems there exists the optimal noise intensity at which the sensory capacity, the information-thermodynamic efficiency, and the total entropy production are optimized at the same time. We apply our general result to a model of sensory adaptation of E. coli and find that the sensory capacity is nearly maximal with experimentally realistic parameters.

  13. Correlation, necessity, and sufficiency: Common errors in the scientific reasoning of undergraduate students for interpreting experiments.

    Science.gov (United States)

    Coleman, Aaron B; Lam, Diane P; Soowal, Lara N

    2015-01-01

    Gaining an understanding of how science works is central to an undergraduate education in biology and biochemistry. The reasoning required to design or interpret experiments that ask specific questions does not come naturally, and is an essential part of the science process skills that must be learned for an understanding of how scientists conduct research. Gaps in these reasoning skills make it difficult for students to become proficient in reading primary scientific literature. In this study, we assessed the ability of students in an upper-division biochemistry laboratory class to use the concepts of correlation, necessity, and sufficiency in interpreting experiments presented in a format and context that is similar to what they would encounter when reading a journal article. The students were assessed before and after completion of a laboratory module where necessary vs. sufficient reasoning was used to design and interpret experiments. The assessment identified two types of errors that were commonly committed by students when interpreting experimental data. When presented with an experiment that only establishes a correlation between a potential intermediate and a known effect, students frequently interpreted the intermediate as being sufficient (causative) for the effect. Also, when presented with an experiment that tests only necessity for an intermediate, they frequently made unsupported conclusions about sufficiency, and vice versa. Completion of the laboratory module and instruction in necessary vs. sufficient reasoning showed some promise for addressing these common errors. © 2015 The International Union of Biochemistry and Molecular Biology.

  14. How, When, and Where? Assessing Renewable Energy Self-Sufficiency at the Neighborhood Level.

    Science.gov (United States)

    Grosspietsch, David; Thömmes, Philippe; Girod, Bastien; Hoffmann, Volker H

    2018-02-20

    Self-sufficient decentralized systems challenge the centralized energy paradigm. Although scholars have assessed specific locations and technological aspects, it remains unclear how, when, and where energy self-sufficiency could become competitive. To address this gap, we develop a techno-economic model for energy self-sufficient neighborhoods that integrates solar photovoltaics (PV), conversion, and storage technologies. We assess the cost of 100% self-sufficiency for both electricity and heat, comparing different technical configurations for a stylized neighborhood in Switzerland and juxtaposing these findings with projections on market and technology development. We then broaden the scope and vary the neighborhood's composition (residential share) and geographic position (along different latitudes). Regarding how to design self-sufficient neighborhoods, we find two promising technical configurations. The "PV-battery-hydrogen" configuration is projected to outperform a fossil-fueled and grid-connected reference configuration when energy prices increase by 2.5% annually and cost reductions in hydrogen-related technologies by a factor of 2 are achieved. The "PV-battery" configuration would allow achieving parity with the reference configuration sooner, at 21% cost reduction. Additionally, more cost-efficient deployment is found in neighborhoods where the end-use is small commercial or mixed and in regions where seasonal fluctuations are low and thus allow for reducing storage requirements.

  15. Profitability analysis of grid-connected photovoltaic facilities for household electricity self-sufficiency

    International Nuclear Information System (INIS)

    Colmenar-Santos, Antonio; Campíñez-Romero, Severo; Pérez-Molina, Clara; Castro-Gil, Manuel

    2012-01-01

    Spain exhibits a high level of energy dependence and has significant solar energy resources. These two facts have given rise to the prominence that renewable energy, particularly solar photovoltaic technology, has enjoyed in recent years, supported by a favorable regulatory framework. Currently, the Spanish Government is providing new ways in energy policy to enhance and accelerate the development of low-power photovoltaic generation facilities for self-consumption by introducing energy policies for feed-in payments of surplus electricity. Such facilities are an example of distributed electrical generation with important benefits for the environment and the rest of the electrical system because, when properly managed, they can help improve the system’s stability and reduce overall losses. By analyzing household demand and solar photovoltaic energy resources, the profitability of such facilities is considered in this article, taking into account the technical and economic impact of storage systems and proposing models for feed-in payments of surplus electricity, in an attempt to assess whether this method of electricity generation versus the method of conventionally supplied power from a grid at a regulated tariff can rival each other economically, in terms of parity. - Highlight: ► The use of grid-connected photovoltaic facilities for household electricity self-sufficiency is presented. ► The need for legal frameworks that include retributive mechanisms for the surplus energy is pointed out. ► Two models are proposed for the remuneration of surplus energy generated. ► Models show economic profitability without feed-in-tariff or compensations. ► Facilities described offer ancillary services for grid stability and smart-grid integration.

  16. Social Experience Is Sufficient to Modulate Sleep Need of Drosophila without Increasing Wakefulness.

    Science.gov (United States)

    Lone, Shahnaz Rahman; Potdar, Sheetal; Srivastava, Manishi; Sharma, Vijay Kumar

    2016-01-01

    Organisms quickly learn about their surroundings and display synaptic plasticity which is thought to be critical for their survival. For example, fruit flies Drosophila melanogaster exposed to highly enriched social environment are found to show increased synaptic connections and a corresponding increase in sleep. Here we asked if social environment comprising a pair of same-sex individuals could enhance sleep in the participating individuals. To study this, we maintained individuals of D. melanogaster in same-sex pairs for a period of 1 to 4 days, and after separation, monitored sleep of the previously socialized and solitary individuals under similar conditions. Males maintained in pairs for 3 or more days were found to sleep significantly more during daytime and showed a tendency to fall asleep sooner as compared to solitary controls (both measures together are henceforth referred to as "sleep-enhancement"). This sleep phenotype is not strain-specific as it is observed in males from three different "wild type" strains of D. melanogaster. Previous studies on social interaction mediated sleep-enhancement presumed 'waking experience' during the interaction to be the primary underlying cause; however, we found sleep-enhancement to occur without any significant increase in wakefulness. Furthermore, while sleep-enhancement due to group-wise social interaction requires Pigment Dispersing Factor (PDF) positive neurons; PDF positive and CRYPTOCHROME (CRY) positive circadian clock neurons and the core circadian clock genes are not required for sleep-enhancement to occur when males interact in pairs. Pair-wise social interaction mediated sleep-enhancement requires dopamine and olfactory signaling, while visual and gustatory signaling systems seem to be dispensable. These results suggest that socialization alone (without any change in wakefulness) is sufficient to cause sleep-enhancement in fruit fly D. melanogaster males, and that its neuronal control is context-specific.

  17. Social Experience Is Sufficient to Modulate Sleep Need of Drosophila without Increasing Wakefulness.

    Directory of Open Access Journals (Sweden)

    Shahnaz Rahman Lone

    Full Text Available Organisms quickly learn about their surroundings and display synaptic plasticity which is thought to be critical for their survival. For example, fruit flies Drosophila melanogaster exposed to highly enriched social environment are found to show increased synaptic connections and a corresponding increase in sleep. Here we asked if social environment comprising a pair of same-sex individuals could enhance sleep in the participating individuals. To study this, we maintained individuals of D. melanogaster in same-sex pairs for a period of 1 to 4 days, and after separation, monitored sleep of the previously socialized and solitary individuals under similar conditions. Males maintained in pairs for 3 or more days were found to sleep significantly more during daytime and showed a tendency to fall asleep sooner as compared to solitary controls (both measures together are henceforth referred to as "sleep-enhancement". This sleep phenotype is not strain-specific as it is observed in males from three different "wild type" strains of D. melanogaster. Previous studies on social interaction mediated sleep-enhancement presumed 'waking experience' during the interaction to be the primary underlying cause; however, we found sleep-enhancement to occur without any significant increase in wakefulness. Furthermore, while sleep-enhancement due to group-wise social interaction requires Pigment Dispersing Factor (PDF positive neurons; PDF positive and CRYPTOCHROME (CRY positive circadian clock neurons and the core circadian clock genes are not required for sleep-enhancement to occur when males interact in pairs. Pair-wise social interaction mediated sleep-enhancement requires dopamine and olfactory signaling, while visual and gustatory signaling systems seem to be dispensable. These results suggest that socialization alone (without any change in wakefulness is sufficient to cause sleep-enhancement in fruit fly D. melanogaster males, and that its neuronal control is

  18. [The REACH legislation: the consumer and environment protection perspective].

    Science.gov (United States)

    Gundert-Remy, Ursula

    2008-12-01

    REACH has been initiated with the aim of improving existing legislation. In order to assist in the interpretation of the REACH legislation, guidance documents have been developed, which have only lately become available. According to the REACH annexes and supported by guidance documents, waiving of test requirements will be possible, thus, opening the possibility that under REACH no new (eco)toxicological data will be required. Concerning products, a guidance document was released in April 2008 stating that the substance concentration threshold of 0.1 % (w/w) applies to the article as produced or imported and it does not relate to the homogeneous materials or parts of an article, but relates to the article as such (i.e., as produced or imported). Hence, notification will not be required for many products containing chemicals with properties which place them on the candidate list for authorization. In summary, it is at present not foreseeable whether the expected benefit of the REACH legislation will materialise for the environment and for the health of consumers and at the work place.

  19. New Stream-reach Development: A Comprehensive Assessment of Hydropower Energy Potential in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Kao, Shih-Chieh [ORNL; McManamay, Ryan A [ORNL; Stewart, Kevin M [ORNL; Samu, Nicole M [ORNL; Hadjerioua, Boualem [ORNL; DeNeale, Scott T [ORNL; Yeasmin, Dilruba [California State University, Fresno; Pasha, M. Fayzul K. [California State University, Fresno; Oubeidillah, Abdoul A [ORNL; Smith, Brennan T [ORNL

    2014-04-01

    The rapid development of multiple national geospatial datasets related to topography, hydrology, and environmental characteristics in the past decade have provided new opportunities for the refinement of hydropower resource potential from undeveloped stream-reaches. Through 2011 to 2013, the Oak Ridge National Laboratory (ORNL) was tasked by the Department of Energy (DOE) Water Power Program to evaluate the new stream-reach development (NSD) resource potential for more than 3 million US streams. A methodology was designed that contains three main components: (1) identification of stream-reaches with high energy density, (2) topographical analysis of stream-reaches to estimate inundated surface area and reservoir storage, and (3) environmental attribution to spatially join information related to the natural ecological systems, social and cultural settings, policies, management, and legal constraints to stream-reaches of energy potential. An initial report on methodology (Hadjerioua et al., 2013) was later reviewed and revised based on the comments gathered from two peer review workshops. After implementing the assessment across the entire United States, major findings were summarized in this final report. The estimated NSD capacity and generation, including both higher-energy-density (>1 MW per reach) and lower-energy-density (<1 MW per reach) stream-reaches is 84.7 GW, around the same size as the existing US conventional hydropower nameplate capacity (79.5 GW; NHAAP, 2013). In terms of energy, the total undeveloped NSD generation is estimated to be 460 TWh/year, around 169% of average 2002 2011 net annual generation from existing conventional hydropower plants (272 TWh/year; EIA, 2013). Given the run-of-river assumption, NSD stream-reaches have higher capacity factors (53 71%), especially compared with conventional larger-storage peaking-operation projects that usually have capacity factors of around 30%. The highest potential is identified in the Pacific Northwest

  20. Dissolved organic carbon in the freshwater tidal reaches of the Schelde estuary

    DEFF Research Database (Denmark)

    Muylaert, K.; Dasseville, R.; De Brabandere, Loreto

    2005-01-01

    To unravel the factors that regulate DOC dynamics in the freshwater tidal reaches of the Schelde estuary, DOC concentration and biodegradability were monitored in the upper Schelde estuary and its major tributaries. Although the Schelde estuary possesses a densely populated and industrialized...... catchment, our data suggest that the bulk of DOC in the freshwater tidal reaches is not derived from waste water. This was concluded from the low biodegradability of DOC (on average 9%), DOC concentrations that are close to the mean for European rivers (4.61 mg/l) and the absence of an inverse relationship....../l), these blooms did not appear to produce large quantities of DOC in the freshwater tidal reaches as DOC concentrations were low when phytoplankton biomass was high. The fact that DOC concentrations were high in winter and decreased in summer suggests a predominantly terrestrial source of DOC in the freshwater...

  1. The Singaporean response to the SARS outbreak: knowledge sufficiency versus public trust.

    Science.gov (United States)

    Deurenberg-Yap, M; Foo, L L; Low, Y Y; Chan, S P; Vijaya, K; Lee, M

    2005-12-01

    knowledge on the one hand and high confidence and trust in the actions of the government on the other suggests that Singaporeans do not require high knowledge sufficiency to be confident in measures undertaken by the government to control the SARS crisis.

  2. Morphological adjustments in a meandering reach of the middle Yangtze River caused by severe human activities

    Science.gov (United States)

    Zhou, Meirong; Xia, Junqiang; Lu, Jinyou; Deng, Shanshan; Lin, Fenfen

    2017-05-01

    In the past 50 years, the Shishou reach in the middle Yangtze River underwent significant channel evolution owing to the implementation of an artificial cutoff, the construction of bank revetment works and the operation of the Three Gorges Project (TGP). Based on the measured hydrological data and topographic data, the processes of channel evolution in this reach were investigated mainly from the adjustments in planform and cross-sectional geometries. The variation in planform geometry obtained in this study indicates that (i) the artificial cutoff at Zhongzhouzi caused the river regime to adjust drastically, with the mean rate of thalweg migration at reach scale of 42.0 m/a over the period 1966-1975; (ii) then the effect of this artificial cutoff reduced gradually, with the mean migration rate decreasing to 40 m/a owing to the occurrence of high water levels in 1993-1998; and (iii) the average annual rate of thalweg migration decreased to 29.3 m/a because of the impacts of various bank protection engineering and the TGP operation during the period 2002-2015. However, remarkable thalweg migration processes still occurred in local regions after the TGP operation, which resulted in significant bankline migration in local reaches of Beimenkou, Shijiatai, and Tiaoxiankou. In addition, the adjustments of bankfull channel geometry were investigated at section and reach scales after the TGP operation. Calculated results show that lateral channel migration in this reach was restricted by various river regulation works and that channel evolution was mainly characterized by an increase in bankfull depth and cross-sectional area. Empirical relationships were developed between the reach-scale bankfull dimensions (depth and area), the bankfull widths at specified sections, and the previous 5-year average fluvial erosion intensity during flood seasons, with high correlation degrees between them being obtained.

  3. A solar house self-sufficient of energy. Experiences on the way to energy autarky

    International Nuclear Information System (INIS)

    Voss, K.; Dohlen, K. v.; Lehmberg, H.; Stahl, W.; Wittwer, C.; Goetzberger, A.

    1994-01-01

    The solar house Freiburg which is self-sufficient of energy was completed in October 1992. After a long and complex planning phase now measuring and monitoring tasks as well as the realization fo improvement measures are to the fore. This article presents exemplary results of the first year of operation and compare them with the expectations. Self-sufficient operation of the building could be attained between April and October 1993. Here among others hydrogen was successfully produced by photovoltaic supplied electrolysis and was to a large degree used for thermal applications (cooking, heating). The fact that the supply of energy was not self-sufficient all the year round was due to the failure of the fuel cell used to produce electric power again with hydrogen. (orig./BWI) [de

  4. Sufficient education attainment for a decent standard of living in modern Australia

    Directory of Open Access Journals (Sweden)

    Emily Joy Callander

    2012-06-01

    Full Text Available Education attainment will impact upon an individual’s capacity to engage in the labour force, their living standards and hence their poverty status. As such, education should be included in measures of poverty. However, it is not known what a sufficient level of education to have a decent standard of living is. Using the 2003 Survey of Disability, Ageing and Carers different levels of education attainment were tested for their association with labour force participation and income. Based upon this, it was concluded that Year 12 or higher is a sufficient level of education attainment for 15 to 64 year olds; and Year 10 or higher for people over the age of 65 years. This is in line with current government policies to improve Year 12 completion rates. Knowing what a ‘sufficient level of education attainment’ is, allows education to be included in multidimensional measures of poverty that view education as a key dimension of disadvantage.

  5. REACH-related substitution within the Danish printing industry

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred; Bøg, Carsten; Markussen, Helene

    are running a substitution project. A major part of the work has been mapping the presence of chemicals which are potential candidates for substitution (e.g. PBT, CMR, vPvB, EDS) within the Danish printing industry. The mapping comprises a combination of a literature study and an investigation of the actual......The accomplishment of the EU REACH regulation will most probably promote substitution within sectors handling a lot of different chemicals like the printing industry. With the aim of being at the cutting edge of this development the Danish EPA together with the Danish printing industry and IPU...... fulfil one or more of the criteria (e.g. CMR, EDS) for the REACH Annex XIV candidate list (authorisation). The paper presents the results of the mapping of chemical candidates and the first results of the actual substitutions. Keywords: REACH, chemicals, substitution, printing industry....

  6. Simple negotiation schemes for agents with simple preferences: sufficiency, necessity and maximality

    NARCIS (Netherlands)

    Chevaleyre, Y.; Endriss, U.; Maudet, N.

    2010-01-01

    We investigate the properties of an abstract negotiation framework where agents autonomously negotiate over allocations of indivisible resources. In this framework, reaching an allocation that is optimal may require very complex multilateral deals. Therefore, we are interested in identifying classes

  7. Apneic oxygenation combined with extracorporeal arteriovenous carbon dioxide removal provides sufficient gas exchange in experimental lung injury

    DEFF Research Database (Denmark)

    Nielsen, Niels Dalsgaard; Kjærgaard, Benedict; Nielsen, Jakob Koefoed

    In this porcine lung injury model, apneic oxygenation with arteriovenous CO2 removal provided sufficient gas exchange and stable hemodynamics, indicating that the method might have a potential in the treatment of severe ARDS.   Acknowledgements The membrane lungs were kindly provided by Novalung GmbH, Germany.......Background and aim of study We hypothesized that continuous high airway pressure without ventilatory movements (apneic oxygenation), using an open lung approach, combined with extracorporeal, pumpless, arterio-venous, carbon dioxide (CO2) removal would provide adequate gas exchange in acute lung...

  8. Energy Self-sufficiency from an Emergy Perspective Exemplified by a Model System of a Danish Farm Cooperative

    DEFF Research Database (Denmark)

    Østergård, Hanne; Markussen, Mads Ville

    2010-01-01

    flow for labor in different ways. The five farms produce bioenergy (biodiesel from oil seed rape and electricity and hot water from anaerobic fermentation of grass-clover), food and fodder (cereals and legumes) and green manure (effluent from biogas production). All green manure, about half......Contemporary food production is highly dependent on fossil fuel for production of fertilizer and as diesel for field operations. One way to enhance agricultural resilience is to increase self-sufficiency at the farm level with necessities such as energy, food, fodder, nutrients and seed. It is even...

  9. [Effect of vitamin beverages on vitamin sufficiency of the workers of Pskov Hydroelectric Power-Plant].

    Science.gov (United States)

    Spiricheva, T V; Vrezhesinskaia, O A; Beketova, N A; Pereverzeva, O G; Kosheleva, O V; Kharitonchik, L A; Kodentsova, V M; Iudina, A V; Spirichev, V B

    2010-01-01

    The research of influence of vitamin complexes in the form of a drink or kissel on vitamin sufficiency of working persons has been carried out. Long inclusion (6,5 months) in a diet of vitamin drinks containing about 80% from recommended daily consumption of vitamins, was accompanied by trustworthy improvement of vitamins C and B6 sufficiency and prevention of seasonal deterioration of beta-carotene status. As initially surveyed have been well provided with vitamins A and E, their blood serum level increase had not occurred.

  10. PENENTUAN CADANGAN PREMI DENGAN METODE PREMIUM SUFFICIENCY PADA ASURANSI JIWA SEUMUR HIDUP JOINT LIFE

    OpenAIRE

    NI PUTU MIRAH PERMATASARI; I NYOMAN WIDANA; KARTIKA SARI

    2016-01-01

    The aim of this research was to get the formula of premium reserves through the premium sufficiency method. Premium reserve is the amount of fund that is collected by the insurance company in preparation for the claim’s payment. Premium sufficiency method is gross premium calculation. To construct that formula, this research used Tabel Mortalitas Indonesia (TMI) 2011, interest rate 2.5% and cost of alpha %. Based on simulation result in men premium reserve value of age 1 of 56 years propotio...

  11. PENENTUAN CADANGAN PREMI DENGAN METODE PREMIUM SUFFICIENCY PADA ASURANSI JIWA SEUMUR HIDUP JOINT LIFE

    Directory of Open Access Journals (Sweden)

    NI PUTU MIRAH PERMATASARI

    2016-08-01

    Full Text Available The aim of this research was to get the formula of premium reserves through the premium sufficiency method. Premium reserve is the amount of fund that is collected by the insurance company in preparation for the claim’s payment. Premium sufficiency method is gross premium calculation. To construct that formula, this research used Tabel Mortalitas Indonesia (TMI 2011, interest rate 2.5% and cost of alpha %. Based on simulation result in men premium reserve value of age 1 of 56 years propotional with insured periods, but after56 years enhancement of premium reserve value.

  12. EVALUATION OF FOOD SELF-SUFFICIENCY OF THE REPUBLIC OF TATARSTAN DISTRICTS

    Directory of Open Access Journals (Sweden)

    R. E. Mansurov

    2017-01-01

    Full Text Available The article presents the author's method for estimation of the level of food self-sufficiency for the main types of food products in the regions of Republic of Tatarstan. The proposed method is based on the use of analytical methods and mathematical comparative analysis to compose a final rating. The proposed method can be used in the system of regional management of agro-industrial complex on the federal and local level. Relevance. The relevance of this work is caused by on the one hand a hardening of foreign policy that may negatively impact on national food security, and on the other hand the state crisis of the domestic agricultural sector. All this requires the development of new approaches to regional agribusiness management. Goal. To develop a methodology is used to assess the level of food self-sufficiency. To rate the level of self-sufficiency in main types of foodstuff in regions of Republic of Tatarstan. Materials and Methods. Statistical data of the results of the AIC of the Republic of Tatarstan for 2016 was used for the study. Analytical methods, including mathematical analysis and comparison were used. Results. Based on the analysis of the present situation for ensuring of food security in Russia it was shown that now it is necessary to develop effective indicators identifying the level of self-sufficiency in basic food regions. It was also revealed that there are no such indicators in system of regional agrarian and industrial complex at present time. As a result of analysis existing approaches the author's method of rating the level of self-sufficiency of regions was offered. This method was adopted on the example of the Republic of Tatarstan. Conclusions. The proposed method of rating estimation of self-sufficiency for basic foodstuffs can be used in the regional agroindustrial complex management system at the federal and local level. It can be used to rank areas in terms of their self-sufficiency for basic foodstuffs. This

  13. Telerobotic operation of structurally flexible, long-reach manipulators

    International Nuclear Information System (INIS)

    Kwon, D.S.; Hwang, D.H.; Babcock, S.M.

    1994-01-01

    As a part of the Department of Energy's Environmental Restoration and Waste Management Program, long-reach manipulators are being considered for the retrieval of waste from large storage tanks. Long-reach manipulators may have characteristics significantly different from those of typical industrial robots because of the flexibility of long links needed to cover the large workspace. To avoid structural vibrations during operation, control algorithms employing various types of shaping filters were investigated. A new approach that uses embedded simulation was developed and compared with others. In the new approach, generation of joint trajectories considering link flexibility was also investigated

  14. Emergency management: does it have a sufficiently comprehensive understanding of decision-making, process and context?

    International Nuclear Information System (INIS)

    Niculae, C.

    2003-01-01

    Full text: It is now widely recognized in the social and management sciences that the effective support of decision-making requires a multi-disciplinary perspective, with businesses increasingly using inter-disciplinary teams. This trend is also seen in nuclear emergency management, for example in the UK inter-disciplinary groups are formed to focus on specific topics such as remediation where their recommendations are feed to the decision makers. The necessity of taking a multi-disciplinary perspective is particularly important for contexts in which the decision makers are likely to be under high stress and so could revert to instinctive patterns of behaviour and modes of communication found in their core disciplines. Yet when we look at the design of the information systems produced to support emergency management, we find a very partial set of disciplinary perspectives providing a strongly rationalistic, technocratic view. These systems have been developed by the technical community with little consultation with non-expert decision makers and limited understanding of emergency management processes across Europe and the social systems with which they interact. In this paper we have considered the Cynefin model, developed by IBM, which draws together much of the work on decision making and decision context over the past 30-40 years, describing the possible contexts in which decision-making may take place, the known, the knowable, the complex and the chaotic space. The known space is the realm of scientific knowledge where the cause and effect are understood. Next, there is the knowable space the realm of scientific enquiry where the cause and effect can be determined with sufficient data. In the complex space there are many interacting cause and effects, to the extent that we do not have sufficiently refined models to predict what will happen as a consequence of any particular actions and the cause and effect may only be explained after the event. In the chaotic

  15. Heterogeneous hyporheic zone dechlorination of a TCE groundwater plume discharging to an urban river reach.

    Science.gov (United States)

    Freitas, Juliana G; Rivett, Michael O; Roche, Rachel S; Durrant Neé Cleverly, Megan; Walker, Caroline; Tellam, John H

    2015-02-01

    The typically elevated natural attenuation capacity of riverbed-hyporheic zones is expected to decrease chlorinated hydrocarbon (CHC) groundwater plume discharges to river receptors through dechlorination reactions. The aim of this study was to assess physico-chemical processes controlling field-scale variation in riverbed-hyporheic zone dechlorination of a TCE groundwater plume discharge to an urban river reach. The 50-m long pool-riffle-glide reach of the River Tame in Birmingham (UK) studied is a heterogeneous high energy river environment. The shallow riverbed was instrumented with a detailed network of multilevel samplers. Freeze coring revealed a geologically heterogeneous and poorly sorted riverbed. A chlorine number reduction approach provided a quantitative indicator of CHC dechlorination. Three sub-reaches of contrasting behaviour were identified. Greatest dechlorination occurred in the riffle sub-reach that was characterised by hyporheic zone flows, moderate sulphate concentrations and pH, anaerobic conditions, low iron, but elevated manganese concentrations with evidence of sulphate reduction. Transient hyporheic zone flows allowing input to varying riverbed depths of organic matter are anticipated to be a key control. The glide sub-reach displayed negligible dechlorination attributed to the predominant groundwater baseflow discharge condition, absence of hyporheic zone, transition to more oxic conditions and elevated sulphate concentrations expected to locally inhibit dechlorination. The tail-of-pool-riffle sub-reach exhibited patchy dechlorination that was attributed to sub-reach complexities including significant flow bypass of a low permeability, high organic matter, silty unit of high dechlorination potential. A process-based conceptual model of reach-scale dechlorination variability was developed. Key findings of practitioner relevance were: riverbed-hyporheic zone CHC dechlorination may provide only a partial, somewhat patchy barrier to CHC

  16. Task-dependent vestibular feedback responses in reaching

    NARCIS (Netherlands)

    Keyser, J.; Medendorp, W.P.; Selen, L.P.J.

    2017-01-01

    When reaching for an earth-fixed object during self-rotation, the motor system should appropriately integrate vestibular signals and sensory predictions to compensate for the intervening motion and its induced inertial forces. While it is well established that this integration occurs rapidly, it is

  17. Reaching the Unreached - Special Emphasis on the Communication ...

    African Journals Online (AJOL)

    This paper provides an overview of the existing communication component in the Expanded Program on Immunisation (EPI) training in Zambia and critically analyses the need for a humane touch in the communication process so as to reach the target audience effectively. Interpersonal Communication (IPC) in Zambia has ...

  18. Shaping of Reach-to-Grasp Kinematics by Intentions

    DEFF Research Database (Denmark)

    Egmose, Ida; Køppe, Simo

    2017-01-01

    is primarily associated with transporting the hand to the object (i.e., extrinsic object properties), the decelerating part of the reach is used as a preparation for object manipulation (i.e., prepare the grasp or the subsequent action), and the grasp is associated with manipulating the object's intrinsic...

  19. Recognition for reaching the most vulnerable populations in Burkina ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Recognition for reaching the most vulnerable populations in Burkina Faso. 07 novembre 2016. An IDRC supported project was recognized for its efforts to improve health service provision and the monitoring of pregnant women, new mothers, children, and people living with HIV in Burkina Faso's Nouna district. Dr Maurice ...

  20. Object Permanence, Reaching, and Locomotion in Infants Who Are Blind.

    Science.gov (United States)

    Ross, S.; Tobin, M. J.

    1997-01-01

    The literature on the effects of congenital blindness on infants' development of motor functions and concepts of object permanence is reviewed. The article questions the idea that infants must first develop an object concept before sound clues alone will elicit reaching. Possible interventions to redress the effects of congenital blindness on…

  1. Reaching an understanding innovations in how we view reading assessment

    CERN Document Server

    Sabatini, John; O'Reilly, Tenaha

    2012-01-01

    Reaching an Understanding: Innovations in How We View Reading Assessment builds upon the editors previous book Measuring Up: Advances in How We Assess Reading Ability by representing some early attempts to apply theory to help guide the development of new assessments and measurement models.

  2. Nanshan Aluminum Reached Strategic Cooperation with CSR Corporation Limited

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    As a key supplier of aluminum profiles and aluminum plate,sheet and trip products for CSR Corporation Limited,Nanshan Aluminum will join hands with CSR Corporation Limited to reach strategic cooperation.On January 5,Nanshan Aluminum signed strategic cooperation agreement with CSR Sifang Locomotive&Rolling; Stock Co.,Ltd,both

  3. An Assessment of EU 2020 Strategy: Too Far to Reach?

    Science.gov (United States)

    Colak, Mehmet Selman; Ege, Aylin

    2013-01-01

    In 2010, EU adopted a new growth strategy which includes three growth priorities and five headline targets to be reached by 2020. The aim of this paper is to investigate the current performance of the EU member and candidate states in achieving these growth priorities and the overall strategy target by allocating the headline targets into the…

  4. Development of postural adjustments during reaching in infants with CP

    NARCIS (Netherlands)

    Hadders-Algra, M; van der Fits, IBM; Stremmelaar, EF; Touwen, BCL

    1999-01-01

    The development of postural adjustments during reaching movements was longitudinally studied in seven infants with cerebral palsy (CP) between 4 and 18 months of age. Five infants developed spastic hemiplegia, one spastic tetraplegia, and one spastic tetraplegia with athetosis. Each assessment

  5. Evaluation of the Implementation of the Reaching Every District ...

    African Journals Online (AJOL)

    46987.2

    ABSTRACT. Background: In 2003, the Government of Zambia in collaboration with implementing partners in immunisation introduced the Reaching Every District. (RED) strategy to improve immunization coverage. The aim of this study is to evaluate the implementation of the. RED strategy in Lusaka district. Methods: A ...

  6. Reach for the Stars: Visions for Literacy Coaching Programs

    Science.gov (United States)

    DeFord, Diane

    2012-01-01

    This brief by the Literacy Coaching Clearinghouse is about reaching for the stars--stories of vision and commitment from educators in small and large schools. Everyone knows of people who are held up as "visionaries" throughout history: Leonardo Da Vinci, Mahatma Gandhi, Jules Verne, Thomas Edison, Susan Anthony, or John Dewey, to name a few. The…

  7. Advanced reach tool (ART) : Development of the mechanistic model

    NARCIS (Netherlands)

    Fransman, W.; Tongeren, M. van; Cherrie, J.W.; Tischer, M.; Schneider, T.; Schinkel, J.; Kromhout, H.; Warren, N.; Goede, H.; Tielemans, E.

    2011-01-01

    This paper describes the development of the mechanistic model within a collaborative project, referred to as the Advanced REACH Tool (ART) project, to develop a tool to model inhalation exposure for workers sharing similar operational conditions across different industries and locations in Europe.

  8. Reaching the Summit: Deaf Adults as Essential Partners in Education

    Science.gov (United States)

    Bourne-Firl, Bridgetta

    2016-01-01

    How do we reach the summit in terms of supporting the best transition possible for each young deaf or hard of hearing individual in the United States? Should professionals who are hearing work alone to succeed with deaf and hard of hearing students? No matter how good the intention, if we want deaf and hard of hearing students to transition from…

  9. Reaching the Millennium Development Goals : Mauritania Should Care

    OpenAIRE

    Magnoli Bocchi, Alessandro; Pontara, Nicola; Fall, Khayar; Tejada, Catalina M.; Gallego Cuervo, Pablo

    2008-01-01

    Mauritania is a resource-rich developing country. As many other African nations, it will not reach most of the Millennium Development Goals, unless the authorities commit to accelerating progress. To succeed by 2015, the government needs to: mobilize additional financial resources, introduce policy changes at the sector level, and strengthen the links between strategic objectives and the b...

  10. Patterns of arm muscle activation involved in octopus reaching movements.

    Science.gov (United States)

    Gutfreund, Y; Flash, T; Fiorito, G; Hochner, B

    1998-08-01

    The extreme flexibility of the octopus arm allows it to perform many different movements, yet octopuses reach toward a target in a stereotyped manner using a basic invariant motor structure: a bend traveling from the base of the arm toward the tip (Gutfreund et al., 1996a). To study the neuronal control of these movements, arm muscle activation [electromyogram (EMG)] was measured together with the kinematics of reaching movements. The traveling bend is associated with a propagating wave of muscle activation, with maximal muscle activation slightly preceding the traveling bend. Tonic activation was occasionally maintained afterward. Correlation of the EMG signals with the kinematic variables (velocities and accelerations) reveals that a significant part of the kinematic variability can be explained by the level of muscle activation. Furthermore, the EMG level measured during the initial stages of movement predicts the peak velocity attained toward the end of the reaching movement. These results suggest that feed-forward motor commands play an important role in the control of movement velocity and that simple adjustment of the excitation levels at the initial stages of the movement can set the velocity profile of the whole movement. A simple model of octopus arm extension is proposed in which the driving force is set initially and is then decreased in proportion to arm diameter at the bend. The model qualitatively reproduces the typical velocity profiles of octopus reaching movements, suggesting a simple control mechanism for bend propagation in the octopus arm.

  11. How infants' reaches reveal principles of sensorimotor decision making

    Science.gov (United States)

    Dineva, Evelina; Schöner, Gregor

    2018-01-01

    In Piaget's classical A-not-B-task, infants repeatedly make a sensorimotor decision to reach to one of two cued targets. Perseverative errors are induced by switching the cue from A to B, while spontaneous errors are unsolicited reaches to B when only A is cued. We argue that theoretical accounts of sensorimotor decision-making fail to address how motor decisions leave a memory trace that may impact future sensorimotor decisions. Instead, in extant neural models, perseveration is caused solely by the history of stimulation. We present a neural dynamic model of sensorimotor decision-making within the framework of Dynamic Field Theory, in which a dynamic instability amplifies fluctuations in neural activation into macroscopic, stable neural activation states that leave memory traces. The model predicts perseveration, but also a tendency to repeat spontaneous errors. To test the account, we pool data from several A-not-B experiments. A conditional probabilities analysis accounts quantitatively how motor decisions depend on the history of reaching. The results provide evidence for the interdependence among subsequent reaching decisions that is explained by the model, showing that by amplifying small differences in activation and affecting learning, decisions have consequences beyond the individual behavioural act.

  12. Advanced REACH tool: A Bayesian model for occupational exposure assessment

    NARCIS (Netherlands)

    McNally, K.; Warren, N.; Fransman, W.; Entink, R.K.; Schinkel, J.; Van Tongeren, M.; Cherrie, J.W.; Kromhout, H.; Schneider, T.; Tielemans, E.

    2014-01-01

    This paper describes a Bayesian model for the assessment of inhalation exposures in an occupational setting; the methodology underpins a freely available web-based application for exposure assessment, the Advanced REACH Tool (ART). The ART is a higher tier exposure tool that combines disparate

  13. On stiffening cables of a long reach manipulator

    International Nuclear Information System (INIS)

    Wang, S.L.; Santiago, P.

    1996-01-01

    A long reach manipulator will be used for waste remediation in large underground storage tanks. The manipulator's slenderness makes it flexible and difficult to control. A low-cost and effective method to enhance the manipulator's stiffness is proposed in this research by using suspension cables. These cables can also be used to accurately measure the position of the manipulator's wrist

  14. Challenges of extension workers in reaching rural women farmers in ...

    African Journals Online (AJOL)

    The study examined the challenges of extension workers in reaching rural women farmers in Enugu State Nigeria. Questionnaire was used to collect data from a sample size of 52 extension workers. Data were analyzed using percentage, mean statistic, chart and factor analysis. Results revealed that training and visit ...

  15. Quality, Reach, and Impact of Open Scholarly Publishing in Latin ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Quality, Reach, and Impact of Open Scholarly Publishing in Latin America. Better understanding Open Access of scholarly research will help determine how it contributes to the greater circulation of knowledge and disseminating research in Latin America. Open Access (defined as unrestricted access to articles published in ...

  16. The Internet and the Global Reach of EU law

    DEFF Research Database (Denmark)

    Kuner, Christopher Barth

    and learning; international negotiation; coercion and conditionality; and blocking recognition of third country legal measures. The EU’s actions in exercising its global reach implicate important normative issues, such as distinguishing between the furtherance of core EU legal values and the advancement...

  17. Operation of CANDU power reactor in thorium self-sufficient fuel cycle

    Indian Academy of Sciences (India)

    These disadvantages of thorium fuel cycle were seemingly the reasons why that ... According to the data of figure 2, maximum (equilibrium) content of 233U in ..... Self-sufficient mode is related with rather big effort in the extraction of isotopes of.

  18. Evaluating the sufficiency of protected lands for maintaining wildlife population connectivity in the northern Rocky Mountains

    Science.gov (United States)

    Samuel A. Cushman; Erin L. Landguth; Curtis H. Flather

    2012-01-01

    Aim: The goal of this study was to evaluate the sufficiency of the network of protected lands in the U.S. northern Rocky Mountains in providing protection for habitat connectivity for 105 hypothetical organisms. A large proportion of the landscape...

  19. Stability of matrices with sufficiently strong negative-dominant-diagonal submatrices

    NARCIS (Netherlands)

    Nieuwenhuis, H.J.; Schoonbeek, L.

    A well-known sufficient condition for stability of a system of linear first-order differential equations is that the matrix of the homogeneous dynamics has a negative dominant diagonal. However, this condition cannot be applied to systems of second-order differential equations. In this paper we

  20. A Sufficient Condition for an Interval Matrix to have Full Column Rank

    Czech Academy of Sciences Publication Activity Database

    Rohn, Jiří

    2017-01-01

    Roč. 22, č. 2 (2017), s. 59-66 ISSN 1560-7534 Institutional support: RVO:67985807 Keywords : interval matrix * full column rank * sufficient condition * double condition Subject RIV: BA - General Mathematics OBOR OECD: Applied mathematics http://www.ict.nsc.ru/jct/annotation/1779?l=eng

  1. Can British Columbia Achieve Electricity Self-Sufficiency and Meet its Renewable Portfolio Standard?

    NARCIS (Netherlands)

    Sopinka, A.; Kooten, van G.C.; Wong, L.

    2012-01-01

    British Columbia’s energy policy is at a crossroads; the province has set a goal of electricity self-sufficiency, a 93% renewable portfolio standard and provincial natural gas strategy that could increase electricity consumption by 2,500-3,800 MW. To ascertain the reality of BC’s supply position, we

  2. Use of Monte Carlo Bootstrap Method in the Analysis of Sample Sufficiency for Radioecological Data

    International Nuclear Information System (INIS)

    Silva, A. N. C. da; Amaral, R. S.; Araujo Santos Jr, J.; Wilson Vieira, J.; Lima, F. R. de A.

    2015-01-01

    There are operational difficulties in obtaining samples for radioecological studies. Population data may no longer be available during the study and obtaining new samples may not be possible. These problems do the researcher sometimes work with a small number of data. Therefore, it is difficult to know whether the number of samples will be sufficient to estimate the desired parameter. Hence, it is critical do the analysis of sample sufficiency. It is not interesting uses the classical methods of statistic to analyze sample sufficiency in Radioecology, because naturally occurring radionuclides have a random distribution in soil, usually arise outliers and gaps with missing values. The present work was developed aiming to apply the Monte Carlo Bootstrap method in the analysis of sample sufficiency with quantitative estimation of a single variable such as specific activity of a natural radioisotope present in plants. The pseudo population was a small sample with 14 values of specific activity of 226 Ra in forage palm (Opuntia spp.). Using the R software was performed a computational procedure to calculate the number of the sample values. The re sampling process with replacement took the 14 values of original sample and produced 10,000 bootstrap samples for each round. Then was calculated the estimated average θ for samples with 2, 5, 8, 11 and 14 values randomly selected. The results showed that if the researcher work with only 11 sample values, the average parameter will be within a confidence interval with 90% probability . (Author)

  3. The sufficient condition for an extremum in the classical action integral as an eingenvalue problem

    International Nuclear Information System (INIS)

    Hussein, M.S.; Pereira, J.G.

    The sufficient condition for an extremum in the classical action integral is studied using Morse's theory. Applications to the classical harmonic and anharmonic oscillators are made. The analogy of the calculations to the quantum mechanical problems in one dimension is stressed. (Author) [pt

  4. Sufficient condition for black-hole formation in spherical gravitational collapse

    International Nuclear Information System (INIS)

    Giambo, Roberto; Giannoni, Fabio; Magli, Giulio

    2002-01-01

    A sufficient condition for the validity of cosmic censorship in spherical gravitational collapse is formulated and proved. The condition relies on an attractive mathematical property of the apparent horizon, which holds if 'minimal' requirements of physical reasonableness are satisfied by the matter model. (letter to the editor)

  5. Sufficient conditions for BIBO robust stabilization : given by the gap metric

    NARCIS (Netherlands)

    Zhu, S.Q.; Hautus, M.L.J.; Praagman, C.

    1987-01-01

    A relation between coprlme fractions and the gap metric is presented. Using this result we provide some sufficient conditions for BIBO robust stabilization for a very wide class of systems. These conditions allow the plant and compensator to be disturbed simultaneously. Keywords: Robust

  6. Sufficient conditions for robust BIBO stabilization : given by the gap metric

    NARCIS (Netherlands)

    Zhu, S.Q.; Hautus, M.L.J.; Praagman, C.

    1988-01-01

    A relation between coprime fractions and the gap metric is presented. Using this result we provide some sufficient conditions for robust BIBO stabilization for a wide class of systems. These conditions allow the plant and the compensator to be disturbed simultaneously.

  7. Necessary and sufficient conditions for Hopf bifurcation in tri-neuron equation with a delay

    International Nuclear Information System (INIS)

    Liu Xiaoming; Liao Xiaofeng

    2009-01-01

    In this paper, we consider the delayed differential equations modeling three-neuron equations with only a time delay. Using the time delay as a bifurcation parameter, necessary and sufficient conditions for Hopf bifurcation to occur are derived. Numerical results indicate that for this model, Hopf bifurcation is likely to occur at suitable delay parameter values.

  8. Identification of necessary and sufficient conditions for real non-negativeness of rational matrices

    International Nuclear Information System (INIS)

    Saeed, K.

    1982-12-01

    The necessary and sufficient conditions for real non-negativeness of rational matrices have been identified. A programmable algorithm is developed and is given with its computer flow chart. This algorithm can be used as a general solution to test the real non-negativeness of rational matrices. The computer program assures the feasibility of the suggested algorithm. (author)

  9. Mating motives are neither necessary nor sufficient to create the beauty premium.

    Science.gov (United States)

    Hafenbrädl, Sebastian; Dana, Jason

    2017-01-01

    Mating motives lead decision makers to favor attractive people, but this favoritism is not sufficient to create a beauty premium in competitive settings. Further, economic approaches to discrimination, when correctly characterized, could neatly accommodate the experimental and field evidence of a beauty premium. Connecting labor economics and evolutionary psychology is laudable, but mating motives do not explain the beauty premium.

  10. Necessary and sufficient conditions for the quantum Zeno and anti-Zeno effect

    International Nuclear Information System (INIS)

    Atmanspacher, Harald; Ehm, Werner; Gneiting, Tilmann

    2003-01-01

    A necessary and sufficient condition for the occurrence of the quantum Zeno effect is given, refining a recent conjecture of Luo, Wang and Zhang. An analogous condition is derived for the quantum anti-Zeno effect. Both results rely on a formal connection between the quantum (anti-)Zeno effect and the weak law of large numbers

  11. Necessary and Sufficient Condition for Local Exponential Synchronization of Nonlinear Systems

    NARCIS (Netherlands)

    Andrieu, Vincent; Jayawardhana, Bayu; Tarbouriech, Sophie

    2015-01-01

    Based on recent works on transverse exponential stability, some necessary and sufficient conditions for the existence of a (locally) exponential synchronizer are established. We show that the existence of a structured synchronizer is equivalent to the existence of a stabilizer for the individual

  12. Necessary and Sufficient Conditions for Pareto Optimality in Infinite Horizon Cooperative Differential Games

    NARCIS (Netherlands)

    Reddy, P.V.; Engwerda, J.C.

    2011-01-01

    In this article we derive necessary and sufficient conditions for the existence of Pareto optimal solutions for infinite horizon cooperative differential games. We consider games defined by non autonomous and discounted autonomous systems. The obtained results are used to analyze the regular

  13. Implementing necessary and sufficient standards for radioactive waste management at LLNL

    International Nuclear Information System (INIS)

    Sims, J.M.; Ladran, A.; Hoyt, D.

    1995-01-01

    Lawrence Livermore National Laboratory (LLNL) and the U.S. Department of Energy, Oakland Field Office (DOE/OAK), are participating in a pilot program to evaluate the process to develop necessary and sufficient sets of standards for contractor activities. This concept of contractor and DOE jointly and locally deciding on what constitutes the set of standards that are necessary and sufficient to perform work safely and in compliance with federal, state, and local regulations, grew out of DOE's Department Standards Committee (Criteria for the Department's Standards Program, August 1994, DOE/EH/-0416). We have chosen radioactive waste management activities as the pilot program at LLNL. This pilot includes low-level radioactive waste, transuranic (TRU) waste, and the radioactive component of low-level and TRU mixed wastes. Guidance for the development and implementation of the necessary and sufficient set of standards is provided in open-quotes The Department of Energy Closure Process for Necessary and Sufficient Sets of Standards,close quotes March 27, 1995 (draft)

  14. Sufficient Stochastic Maximum Principle in a Regime-Switching Diffusion Model

    Energy Technology Data Exchange (ETDEWEB)

    Donnelly, Catherine, E-mail: C.Donnelly@hw.ac.uk [Heriot-Watt University, Department of Actuarial Mathematics and Statistics (United Kingdom)

    2011-10-15

    We prove a sufficient stochastic maximum principle for the optimal control of a regime-switching diffusion model. We show the connection to dynamic programming and we apply the result to a quadratic loss minimization problem, which can be used to solve a mean-variance portfolio selection problem.

  15. Sufficient Stochastic Maximum Principle in a Regime-Switching Diffusion Model

    International Nuclear Information System (INIS)

    Donnelly, Catherine

    2011-01-01

    We prove a sufficient stochastic maximum principle for the optimal control of a regime-switching diffusion model. We show the connection to dynamic programming and we apply the result to a quadratic loss minimization problem, which can be used to solve a mean-variance portfolio selection problem.

  16. Sufficient Descent Conjugate Gradient Methods for Solving Convex Constrained Nonlinear Monotone Equations

    Directory of Open Access Journals (Sweden)

    San-Yang Liu

    2014-01-01

    Full Text Available Two unified frameworks of some sufficient descent conjugate gradient methods are considered. Combined with the hyperplane projection method of Solodov and Svaiter, they are extended to solve convex constrained nonlinear monotone equations. Their global convergence is proven under some mild conditions. Numerical results illustrate that these methods are efficient and can be applied to solve large-scale nonsmooth equations.

  17. Sufficient condition for black-hole formation in spherical gravitational collapse

    Energy Technology Data Exchange (ETDEWEB)

    Giambo, Roberto [Dipartimento di Matematica e Fisica, Universita di Camerino (Italy); Giannoni, Fabio [Dipartimento di Matematica e Fisica, Universita di Camerino (Italy); Magli, Giulio [Dipartimento di Matematica, Politecnico di Milano (Italy)

    2002-01-21

    A sufficient condition for the validity of cosmic censorship in spherical gravitational collapse is formulated and proved. The condition relies on an attractive mathematical property of the apparent horizon, which holds if 'minimal' requirements of physical reasonableness are satisfied by the matter model. (letter to the editor)

  18. Operation of CANDU power reactor in thorium self-sufficient fuel cycle

    Indian Academy of Sciences (India)

    This paper presents the results of calculations for CANDU reactor operation in thorium fuel cycle. Calculations are performed to estimate the feasibility of operation of heavy-water thermal neutron power reactor in self-sufficient thorium cycle. Parameters of active core and scheme of fuel reloading were considered to be the ...

  19. Community Service and University Roles: An Action Research Based on the Philosophy of Sufficiency Economy

    Science.gov (United States)

    Nuangchalerm, Prasart; Chansirisira, Pacharawit

    2012-01-01

    This study employs action research to develop community service through university roles by applying the philosophy of sufficiency economy of His Majesty the King Bhumibol Adulyadej to fulfill villagers' way of life. Participatory learning, seminar, field trip and supervision were employed for strategic plan. Data were collected by participatory…

  20. An ecological engineering approach for keeping water from reaching interred wastes in arid or semiarid regions

    International Nuclear Information System (INIS)

    Anderson, J.E.

    1997-01-01

    This paper describes application of a soil-plant cover system (SPCS) to preclude water from reaching interred wastes in arid and semiarid regions. Where potential evapotranspiration far exceeds precipitation, water can be kept from reaching buried wastes by (1) providing a sufficiently deep cap of soil to store precipitation that falls while plants are dormant and (2) maintaining plant cover to deplete soil moisture during the growing season, thereby emptying the storage reservoir. Research at the Idaho National Engineering Laboratory (INEL) has shown that 2 m of soil is adequate to store moisture from snowmelt and spring rains. Healthy stands of perennial grasses and shrubs adapted to the INEL climate use all available soil moisture, even during a very wet growing season. However, burrowing by small mammals or ants may affect the performance of a SPCS by increasing infiltration of water. Intrusion barriers of gravel and cobble can be used to restrict burrowing, but emplacement of such barriers affects soil moisture storage and plant rooting depths. A replicated field experiment to investigate the implications of those effects is in progress. Incorporation of an SPCS should be considered in the design of isolation barriers for shallow land burial of hazardous wastes in and regions

  1. Comparing the Advanced REACH Tool's (ART) Estimates With Switzerland's Occupational Exposure Data.

    Science.gov (United States)

    Savic, Nenad; Gasic, Bojan; Schinkel, Jody; Vernez, David

    2017-10-01

    The Advanced REACH Tool (ART) is the most sophisticated tool used for evaluating exposure levels under the European Union's Registration, Evaluation, Authorisation and restriction of CHemicals (REACH) regulations. ART provides estimates at different percentiles of exposure and within different confidence intervals (CIs). However, its performance has only been tested on a limited number of exposure data. The present study compares ART's estimates with exposure measurements collected over many years in Switzerland. Measurements from 584 cases of exposure to vapours, mists, powders, and abrasive dusts (wood/stone and metal) were extracted from a Swiss database. The corresponding exposures at the 50th and 90th percentiles were calculated in ART. To characterize the model's performance, the 90% CI of the estimates was considered. ART's performance at the 50th percentile was only found to be insufficiently conservative with regard to exposure to wood/stone dusts, whereas the 90th percentile showed sufficient conservatism for all the types of exposure processed. However, a trend was observed with the residuals, where ART overestimated lower exposures and underestimated higher ones. The median was more precise, however, and the majority (≥60%) of real-world measurements were within a factor of 10 from ART's estimates. We provide recommendations based on the results and suggest further, more comprehensive, investigations. © The Author 2017. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

  2. Economic interpretation of environmental flow regime downstream diverted river reaches.

    Science.gov (United States)

    Gorla, Lorenzo; Perona, Paolo

    2013-04-01

    feasible and doesn't imply high costs or advanced management tools. Our approach is a simple but effective step towards eco-sustainability in the growing market of mini hydropower plants, where operation rules like MFR are still widespread. As such, this method is a powerful instrument for political managers to explicit contradictions thus enlightening best compromise measures/decisions. References Perona, P., Characklis, G., Duerrenmatt, D.J., in revision. Inverse parameters estimation of simple riparian benefit economical models. Journal of Environmental Management . Gorla, L. and Perona, P., in revision. On quantifying ecologically sustainable flow releases in a diverted river reach. Journal of Hydrology.

  3. REACH: an effective catalyst for scaling up priority nutrition interventions at the country level.

    Science.gov (United States)

    Pearson, Brenda L; Ljungqvist, Björn

    2011-06-01

    Renewed Efforts Against Child Hunger (REACH) is the joint United Nations initiative to address Millennium Development Goal (MDG) 10, Target 3, i.e., to halve the proportion of underweight children under 5 years old by 2015. The United Nations Food and Agriculture Organization (FAO), the World Health Organization (WHO), the United Nations Children's Fund (UNICEF), the World Food Programme (WFP), and the International Fund for Agricultural Development (IFAD) developed and tested a facilitation mechanism to act as a catalyst for scaling up multisectoral nutrition activities. The UN-REACH partners developed pilot projects in Mauritania and Lao PDR from 2008 to 2010 and deployed facilitators to improve nutrition governance and coordination. Review missions were conducted in February 2011 to assess the REACH approach and what it achieved. The UN review mission members reviewed documents, assessed policy and management indicators, conducted qualitative interviews, and discussed findings with key stakeholders, including the most senior UN nutrition directors from all agencies. Among other UN-REACH achievements, the Prime Minister of Mauritania agreed to preside over a new National Nutrition Development Council responsible for high-level decision-making and setting national policy objectives. REACH facilitated the completion of Lao's first national Nutrition Strategy and Plan of Action and formation of the multistakeholder Nutrition Task Force. During the REACH engagement, coordination, joint advocacy, situation analysis, policy development, and joint UN programming for nutrition were strengthened in Lao PDR and Mauritania. Improvements in the nutrition governance and management mechanisms in Mauritania and Lao PDR were observed during the period of REACH support through increased awareness of nutrition as a key development objective, establishment of governmental multisectoral coordinating mechanisms, improved government capacity, and new joint UN-government nutrition

  4. Switching from reaching to navigation: differential cognitive strategies for spatial memory in children and adults.

    Science.gov (United States)

    Belmonti, Vittorio; Cioni, Giovanni; Berthoz, Alain

    2015-07-01

    Navigational and reaching spaces are known to involve different cognitive strategies and brain networks, whose development in humans is still debated. In fact, high-level spatial processing, including allocentric location encoding, is already available to very young children, but navigational strategies are not mature until late childhood. The Magic Carpet (MC) is a new electronic device translating the traditional Corsi Block-tapping Test (CBT) to navigational space. In this study, the MC and the CBT were used to assess spatial memory for navigation and for reaching, respectively. Our hypothesis was that school-age children would not treat MC stimuli as navigational paths, assimilating them to reaching sequences. Ninety-one healthy children aged 6 to 11 years and 18 adults were enrolled. Overall short-term memory performance (span) on both tests, effects of sequence geometry, and error patterns according to a new classification were studied. Span increased with age on both tests, but relatively more in navigational than in reaching space, particularly in males. Sequence geometry specifically influenced navigation, not reaching. The number of body rotations along the path affected MC performance in children more than in adults, and in women more than in men. Error patterns indicated that navigational sequences were increasingly retained as global paths across development, in contrast to separately stored reaching locations. A sequence of spatial locations can be coded as a navigational path only if a cognitive switch from a reaching mode to a navigation mode occurs. This implies the integration of egocentric and allocentric reference frames, of visual and idiothetic cues, and access to long-term memory. This switch is not yet fulfilled at school age due to immature executive functions. © 2014 John Wiley & Sons Ltd.

  5. Automated River Reach Definition Strategies: Applications for the Surface Water and Ocean Topography Mission

    Science.gov (United States)

    Frasson, Renato Prata de Moraes; Wei, Rui; Durand, Michael; Minear, J. Toby; Domeneghetti, Alessio; Schumann, Guy; Williams, Brent A.; Rodriguez, Ernesto; Picamilh, Christophe; Lion, Christine; Pavelsky, Tamlin; Garambois, Pierre-André

    2017-10-01

    The upcoming Surface Water and Ocean Topography (SWOT) mission will measure water surface heights and widths for rivers wider than 100 m. At its native resolution, SWOT height errors are expected to be on the order of meters, which prevent the calculation of water surface slopes and the use of slope-dependent discharge equations. To mitigate height and width errors, the high-resolution measurements will be grouped into reaches (˜5 to 15 km), where slope and discharge are estimated. We describe three automated river segmentation strategies for defining optimum reaches for discharge estimation: (1) arbitrary lengths, (2) identification of hydraulic controls, and (3) sinuosity. We test our methodologies on 9 and 14 simulated SWOT overpasses over the Sacramento and the Po Rivers, respectively, which we compare against hydraulic models of each river. Our results show that generally, height, width, and slope errors decrease with increasing reach length. However, the hydraulic controls and the sinuosity methods led to better slopes and often height errors that were either smaller or comparable to those of arbitrary reaches of compatible sizes. Estimated discharge errors caused by the propagation of height, width, and slope errors through the discharge equation were often smaller for sinuosity (on average 8.5% for the Sacramento and 6.9% for the Po) and hydraulic control (Sacramento: 7.3% and Po: 5.9%) reaches than for arbitrary reaches of comparable lengths (Sacramento: 8.6% and Po: 7.8%). This analysis suggests that reach definition methods that preserve the hydraulic properties of the river network may lead to better discharge estimates.

  6. Task-dependent vestibular feedback responses in reaching.

    Science.gov (United States)

    Keyser, Johannes; Medendorp, W Pieter; Selen, Luc P J

    2017-07-01

    When reaching for an earth-fixed object during self-rotation, the motor system should appropriately integrate vestibular signals and sensory predictions to compensate for the intervening motion and its induced inertial forces. While it is well established that this integration occurs rapidly, it is unknown whether vestibular feedback is specifically processed dependent on the behavioral goal. Here, we studied whether vestibular signals evoke fixed responses with the aim to preserve the hand trajectory in space or are processed more flexibly, correcting trajectories only in task-relevant spatial dimensions. We used galvanic vestibular stimulation to perturb reaching movements toward a narrow or a wide target. Results show that the same vestibular stimulation led to smaller trajectory corrections to the wide than the narrow target. We interpret this reduced compensation as a task-dependent modulation of vestibular feedback responses, tuned to minimally intervene with the task-irrelevant dimension of the reach. These task-dependent vestibular feedback corrections are in accordance with a central prediction of optimal feedback control theory and mirror the sophistication seen in feedback responses to mechanical and visual perturbations of the upper limb. NEW & NOTEWORTHY Correcting limb movements for external perturbations is a hallmark of flexible sensorimotor behavior. While visual and mechanical perturbations are corrected in a task-dependent manner, it is unclear whether a vestibular perturbation, naturally arising when the body moves, is selectively processed in reach control. We show, using galvanic vestibular stimulation, that reach corrections to vestibular perturbations are task dependent, consistent with a prediction of optimal feedback control theory. Copyright © 2017 the American Physiological Society.

  7. Bimanual reach to grasp movements after cervical spinal cord injury.

    Directory of Open Access Journals (Sweden)

    Laura Britten

    Full Text Available Injury to the cervical spinal cord results in bilateral deficits in arm/hand function reducing functional independence and quality of life. To date little research has been undertaken to investigate control strategies of arm/hand movements following cervical spinal cord injury (cSCI. This study aimed to investigate unimanual and bimanual coordination in patients with acute cSCI using 3D kinematic analysis as they performed naturalistic reach to grasp actions with one hand, or with both hands together (symmetrical task, and compare this to the movement patterns of uninjured younger and older adults. Eighteen adults with a cSCI (mean 61.61 years with lesions at C4-C8, with an American Spinal Injury Association (ASIA grade B to D and 16 uninjured younger adults (mean 23.68 years and sixteen uninjured older adults (mean 70.92 years were recruited. Participants with a cSCI produced reach-to-grasp actions which took longer, were slower, and had longer deceleration phases than uninjured participants. These differences were exacerbated during bimanual reach-to-grasp tasks. Maximal grasp aperture was no different between groups, but reached earlier by people with cSCI. Participants with a cSCI were less synchronous than younger and older adults but all groups used the deceleration phase for error correction to end the movement in a synchronous fashion. Overall, this study suggests that after cSCI a level of bimanual coordination is retained. While there seems to be a greater reliance on feedback to produce both the reach to grasp, we observed minimal disruption of the more impaired limb on the less impaired limb. This suggests that bimanual movements should be integrated into therapy.

  8. MRI of the small bowel: can sufficient bowel distension be achieved with small volumes of oral contrast?

    International Nuclear Information System (INIS)

    Kinner, Sonja; Kuehle, Christiane A.; Ladd, Susanne C.; Barkhausen, Joerg; Herbig, Sebastian; Haag, Sebastian; Lauenstein, Thomas C.

    2008-01-01

    Sufficient luminal distension is mandatory for small bowel imaging. However, patients often are unable to ingest volumes of currently applied oral contrast compounds. The aim of this study was to evaluate if administration of low doses of an oral contrast agent with high-osmolarity leads to sufficient and diagnostic bowel distension. Six healthy volunteers ingested at different occasions 150, 300 and 450 ml of a commercially available oral contrast agent (Banana Smoothie Readi-Cat, E-Z-EM; 194 mOsmol/l). Two-dimensional TrueFISP data sets were acquired in 5-min intervals up to 45 min after contrast ingestion. Small bowel distension was quantified using a visual five-grade ranking (5 very good distension, 1 = collapsed bowel). Results were statistically compared using a Wilcoxon-Rank test. Ingestion of 450 ml and 300 ml resulted in a significantly better distension than 150 ml. The all-over average distension value for 450 ml amounted to 3.4 (300 ml: 3.0, 150 ml: 2.3) and diagnostic bowel distension could be found throughout the small intestine. Even 45 min after ingestion of 450 ml the jejunum and ileum could be reliably analyzed. Small bowel imaging with low doses of contrast leads to diagnostic distension values in healthy subjects when a high-osmolarity substance is applied. These findings may help to further refine small bowel MRI techniques, but need to be confirmed in patients with small bowel disorders. (orig.)

  9. Role of limb and target vision in the online control of memory-guided reaches.

    Science.gov (United States)

    Heath, Matthew

    2005-07-01

    This investigation tested the proposal that a "highly accurate" and temporally unstable stored target representation is available to the motor system for the online control of memory-guided reaches. Participants reached to a target that was: (a) visible during the response, (b) extinguished at movement onset, and (c) occluded for 0, 500, 1,500 and 2,500 ms in advance of response cueing. Additionally, trials were performed with (i.e., limb visible) and without (i.e., limb occluded) vision of the reaching limb. Results showed that limb occluded trials undershot the target location in each target condition, and were characterized by a primarily offline mode of control. In contrast, limb visible trials showed a consistent level of endpoint accuracy for each target condition and elicited more online reaching corrections than limb occluded trials. It is therefore proposed that a reasonably accurate and temporally stable stored target representation can be combined with vision of the moving limb for the online control of memory-guided reaches.

  10. A single alcohol drinking session is sufficient to enable subsequent aversion-resistant consumption in mice.

    Science.gov (United States)

    Lei, Kelly; Wegner, Scott A; Yu, Ji-Hwan; Simms, Jeffrey A; Hopf, F Woodward

    2016-09-01

    Addiction is mediated in large part by pathological motivation for rewarding, addictive substances, and alcohol-use disorders (AUDs) continue to extract a very high physical and economic toll on society. Compulsive alcohol drinking, where intake continues despite negative consequences, is considered a particular obstacle during treatment of AUDs. Aversion-resistant drives for alcohol have been modeled in rodents, where animals continue to consume even when alcohol is adulterated with the bitter tastant quinine, or is paired with another aversive consequence. Here, we describe a two-bottle choice paradigm where C57BL/6 mice first had 24-h access to 15% alcohol or water. Afterward, they drank quinine-free alcohol (alcohol-only) or alcohol with quinine (100 μM), in a limited daily access (LDA) two-bottle-choice paradigm (2 h/day, 5 days/week, starting 3 h into the dark cycle), and achieved nearly binge-level blood alcohol concentrations. Interestingly, a single, initial 24-h experience with alcohol-only enhanced subsequent quinine-resistant drinking. In contrast, mice that drank alcohol-quinine in the 24-h session showed significantly reduced alcohol-quinine intake and preference during the subsequent LDA sessions, relative to mice that drank alcohol-only in the initial 24-h session and alcohol-quinine in LDA sessions. Thus, mice could find the concentration of quinine we used aversive, but were able to disregard the quinine after a single alcohol-only drinking session. Finally, mice had low intake and preference for quinine in water, both before and after weeks of alcohol-drinking sessions, suggesting that quinine resistance was not a consequence of increased quinine preference after weeks of drinking of alcohol-quinine. Together, we demonstrate that a single alcohol-only session was sufficient to enable subsequent aversion-resistant consumption in C57BL/6 mice, which did not reflect changes in quinine taste palatability. Given the rapid development of quinine

  11. Copulation is reactivated by bromocriptine in male rats after reaching sexual satiety with a same sexual mate.

    Science.gov (United States)

    Rojas-Hernández, Jorge; Juárez, Jorge

    2015-11-01

    Male sexual satiety has been associated with a decrease in dopamine levels. Spontaneous recovery of copulatory behavior begins at least 72 h after sexual satiety is reached or in the condition in which a sexually-satiated male is exposed to a new receptive female distinct from the one with which sexual satiety was reached. The aim of the present study was to explore whether dopaminergic activation by bromocriptine (BrCr) can reactivate copulatory behavior with the same sexual mate immediately after sexual satiety is reached. Male rats were divided into three groups exposed to one of the following three conditions: 1) administration of 2 mg/kgs.c. of BrCr and exposure to the same female with whom sexual satiety was previously reached; 2) administration of 0.3 mLs.c. of the vehicle solution with exposure to the same female with whom sexual satiety was reached; and, 3) exposure to a new receptive female after sexual satiety was reached. Results showed that BrCr significantly reactivated copulatory capability in sexually-satiated males with the same receptive female. In contrast, no males in the vehicle group ejaculated with the same female after reaching sexual exhaustion. Copulation was reactivated by BrCr in a way similar to that observed in untreated males exposed to a new receptive female (i.e., the Coolidge effect). The reversal of sexual satiety in the males treated with BrCr could be explained by its action on D2 family receptors, which promotes a reactivation of sexual motivation at a level sufficient to allow renewed copulation with the same female mate. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Translating the REACH Caregiver Intervention for Use by Area Agency on Aging Personnel: the REACH OUT Program

    Science.gov (United States)

    Burgio, Louis D.; Collins, Irene B.; Schmid, Bettina; Wharton, Tracy; McCallum, Debra; DeCoster, Jamie

    2009-01-01

    Purpose: The aim of this study was to translate the evidence-based Resources for Enhancing Alzheimer's Caregiver Health (REACH) II intervention for use in 4 Area Agencies on Aging (AAAs). A secondary aim was to examine possible moderators of treatment outcome. Design and Methods: We used a quasi-experimental pre-post treatment design with no…

  13. Redesigning Schools to Reach Every Student with Excellent Teachers: Change Management--Key Theories to Consider when Extending Reach

    Science.gov (United States)

    Barrett, Sharon Kebschull

    2012-01-01

    As schools, their teachers, and outside facilitators redesign jobs and incorporate technology to extend the reach of excellent teachers to more students and develop an Opportunity Culture for all, choosing the right school models is just one part of the task. The human experience--and experience in education--says that even perfect design will not…

  14. Perceiver as polar planimeter: Direct perception of jumping, reaching, and jump-reaching affordances for the self and others.

    Science.gov (United States)

    Thomas, Brandon J; Hawkins, Matthew M; Nalepka, Patrick

    2017-03-30

    Runeson (Scandanavian Journal of Psychology 18:172-179, 1977) suggested that the polar planimeter might serve as an informative model system of perceptual mechanism. The key aspect of the polar planimeter is that it registers a higher order property of the environment without computational mediation on the basis of lower order properties, detecting task-specific information only. This aspect was posited as a hypothesis for the perception of jumping and reaching affordances for the self and another person. The findings supported this hypothesis. The perception of reaching while jumping significantly differed from an additive combination of jump-without-reaching and reach-without-jumping perception. The results are consistent with Gibson's (The senses considered as perceptual systems, Houghton Mifflin, Boston, MA; Gibson, The senses considered as perceptual systems, Houghton Mifflin, Boston, MA, 1966; The ecological approach to visual perception, Houghton Mifflin, Boston, MA; Gibson, The ecological approach to visual perception, Houghton Mifflin, Boston, MA, 1979) theory of information-that aspects of the environment are specified by patterns in energetic media.

  15. Simulation of Columbia River Floods in the Hanford Reach

    Energy Technology Data Exchange (ETDEWEB)

    Waichler, Scott R.; Serkowski, John A.; Perkins, William A.; Richmond, Marshall C.

    2017-01-30

    Columbia River water elevations and flows in the Hanford Reach affect the environment and facilities along the shoreline, including movement of contaminants in groundwater, fish habitat, and infrastructure subject to flooding. This report describes the hydraulic simulation of hypothetical flood flows using the best available topographic and bathymetric data for the Hanford Reach and the Modular Aquatic Simulation System in 1 Dimension (MASS1) hydrodynamic model. The MASS1 model of the Hanford Reach was previously calibrated to field measurements of water surface elevations. The current model setup can be used for other studies of flow, water levels, and temperature in the Reach. The existing MASS1 channel geometry and roughness and other model configuration inputs for the Hanford Reach were used for this study, and previous calibration and validation results for the model are reprinted here for reference. The flood flows for this study were simulated by setting constant flow rates obtained from the U.S. Army Corps of Engineers (USACE) for the Columbia, Snake, and Yakima Rivers, and a constant water level at McNary Dam, and then running the model to steady state. The discharge levels simulated were all low-probability events; for example, a 100-year flood is one that would occur on average every 100 years, or put another way, in any given year there is a 1% chance that a discharge of that level or higher will occur. The simulated floods and their corresponding Columbia River discharges were 100-year (445,000 cfs), 500-year (520,000 cfs), and the USACE-defined Standard Project Flood (960,000 cfs). The resulting water levels from the steady-state floods can be viewed as “worst case” outcomes for the respective discharge levels. The MASS1 output for water surface elevations was converted to the North American Vertical Datum of 1988 and projected across the channel and land surface to enable mapping of the floodplain for each scenario. Floodplain maps show that for

  16. Reach-to-grasp movement as a minimization process.

    Science.gov (United States)

    Yang, Fang; Feldman, Anatol G

    2010-02-01

    It is known that hand transport and grasping are functionally different but spatially coordinated components of reach-to-grasp (RTG) movements. As an extension of this notion, we suggested that body segments involved in RTG movements are controlled as a coherent ensemble by a global minimization process associated with the necessity for the hand to reach the motor goal. Different RTG components emerge following this process without pre-programming. Specifically, the minimization process may result from the tendency of neuromuscular elements to diminish the spatial gap between the actual arm-hand configuration and its virtual (referent) configuration specified by the brain. The referent configuration is specified depending on the object shape, localization, and orientation. Since the minimization process is gradual, it can be interrupted and resumed following mechanical perturbations, at any phase during RTG movements, including hand closure. To test this prediction of the minimization hypothesis, we asked subjects to reach and grasp a cube placed within the reach of the arm. Vision was prevented during movement until the hand returned to its initial position. As predicted, by arresting wrist motion at different points of hand transport in randomly selected trials, it was possible to halt changes in hand aperture at any phase, not only during hand opening but also during hand closure. Aperture changes resumed soon after the wrist was released. Another test of the minimization hypothesis was made in RTG movements to an object placed beyond the reach of the arm. It has previously been shown (Rossi et al. in J Physiol 538:659-671, 2002) that in such movements, the trunk motion begins to contribute to hand transport only after a critical phase when the shifts in the referent arm configuration have finished (at about the time when hand velocity is maximal). The minimization rule suggests that when the virtual contribution of the arm to hand transport is completed

  17. A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste.

    Directory of Open Access Journals (Sweden)

    John M Tauber

    2017-11-01

    Full Text Available Fat represents a calorically potent food source that yields approximately twice the amount of energy as carbohydrates or proteins per unit of mass. The highly palatable taste of free fatty acids (FAs, one of the building blocks of fat, promotes food consumption, activates reward circuitry, and is thought to contribute to hedonic feeding underlying many metabolism-related disorders. Despite a role in the etiology of metabolic diseases, little is known about how dietary fats are detected by the gustatory system to promote feeding. Previously, we showed that a broad population of sugar-sensing taste neurons expressing Gustatory Receptor 64f (Gr64f is required for reflexive feeding responses to both FAs and sugars. Here, we report a genetic silencing screen to identify specific populations of taste neurons that mediate fatty acid (FA taste. We find neurons identified by expression of Ionotropic Receptor 56d (IR56d are necessary and sufficient for reflexive feeding response to FAs. Functional imaging reveals that IR56d-expressing neurons are responsive to short- and medium-chain FAs. Silencing IR56d neurons selectively abolishes FA taste, and their activation is sufficient to drive feeding responses. Analysis of co-expression with Gr64f identifies two subpopulations of IR56d-expressing neurons. While physiological imaging reveals that both populations are responsive to FAs, IR56d/Gr64f neurons are activated by medium-chain FAs and are sufficient for reflexive feeding response to FAs. Moreover, flies can discriminate between sugar and FAs in an aversive taste memory assay, indicating that FA taste is a unique modality in Drosophila. Taken together, these findings localize FA taste within the Drosophila gustatory center and provide an opportunity to investigate discrimination between different categories of appetitive tastants.

  18. A subset of sweet-sensing neurons identified by IR56d are necessary and sufficient for fatty acid taste.

    Science.gov (United States)

    Tauber, John M; Brown, Elizabeth B; Li, Yuanyuan; Yurgel, Maria E; Masek, Pavel; Keene, Alex C

    2017-11-01

    Fat represents a calorically potent food source that yields approximately twice the amount of energy as carbohydrates or proteins per unit of mass. The highly palatable taste of free fatty acids (FAs), one of the building blocks of fat, promotes food consumption, activates reward circuitry, and is thought to contribute to hedonic feeding underlying many metabolism-related disorders. Despite a role in the etiology of metabolic diseases, little is known about how dietary fats are detected by the gustatory system to promote feeding. Previously, we showed that a broad population of sugar-sensing taste neurons expressing Gustatory Receptor 64f (Gr64f) is required for reflexive feeding responses to both FAs and sugars. Here, we report a genetic silencing screen to identify specific populations of taste neurons that mediate fatty acid (FA) taste. We find neurons identified by expression of Ionotropic Receptor 56d (IR56d) are necessary and sufficient for reflexive feeding response to FAs. Functional imaging reveals that IR56d-expressing neurons are responsive to short- and medium-chain FAs. Silencing IR56d neurons selectively abolishes FA taste, and their activation is sufficient to drive feeding responses. Analysis of co-expression with Gr64f identifies two subpopulations of IR56d-expressing neurons. While physiological imaging reveals that both populations are responsive to FAs, IR56d/Gr64f neurons are activated by medium-chain FAs and are sufficient for reflexive feeding response to FAs. Moreover, flies can discriminate between sugar and FAs in an aversive taste memory assay, indicating that FA taste is a unique modality in Drosophila. Taken together, these findings localize FA taste within the Drosophila gustatory center and provide an opportunity to investigate discrimination between different categories of appetitive tastants.

  19. Integrated testing strategy (ITS) for bioaccumulation assessment under REACH

    DEFF Research Database (Denmark)

    Lombardo, Anna; Roncaglioni, Alessandra; Benfentati, Emilio

    2014-01-01

    in a dossier. REACH promotes the use of alternative methods to replace, refine and reduce the use of animal (eco)toxicity testing. Within the EU OSIRIS project, integrated testing strategies (ITSs) have been developed for the rational use of non-animal testing approaches in chemical hazard assessment. Here we......REACH (registration, evaluation, authorisation and restriction of chemicals) regulation requires that all the chemicals produced or imported in Europe above 1 tonne/year are registered. To register a chemical, physicochemical, toxicological and ecotoxicological information needs to be reported...... present an ITS for evaluating the bioaccumulation potential of organic chemicals. The scheme includes the use of all available data (also the non-optimal ones), waiving schemes, analysis of physicochemical properties related to the end point and alternative methods (both in silico and in vitro). In vivo...

  20. Key Design Requirements for Long-Reach Manipulators

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, D.S.

    2001-01-01

    Long-reach manipulators differ from industrial robots and teleoperators typically used in the nuclear industry in that the aspect ratio (length to diameter) of links is much greater and link flexibility, as well as joint or drive train flexibility, is likely to be significant. Long-reach manipulators will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional, kinematic, and performance requirements, an approach for determining the kinematic applicability and performance characteristics is presented, with a focus on waste storage tank remediation. Requirements are identified, kinematic configurations are considered, and a parametric study of link design parameters and their effects on performance characteristics is presented.

  1. Key design requirements for long-reach manipulators

    International Nuclear Information System (INIS)

    Kwon, D.S.; March-Leuba, S.; Babcock, S.M.; Hamel, W.R.

    1993-09-01

    Long-reach manipulators differ from industrial robots and teleoperators typically used in the nuclear industry in that the aspect ratio (length to diameter) of links is much greater and link flexibility, as well as joint or drive train flexibility, is likely to be significant. Long-reach manipulators will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional kinematic, and performance requirements an approach for determining the kinematic applicability and performance characteristics is presented, with a focus on waste storage tank remediation. Requirements are identified, kinematic configurations are considered, and a parametric study of link design parameters and their effects on performance characteristics is presented

  2. Key Design Requirements for Long-Reach Manipulators

    International Nuclear Information System (INIS)

    Kwon, D.S.

    2001-01-01

    Long-reach manipulators differ from industrial robots and teleoperators typically used in the nuclear industry in that the aspect ratio (length to diameter) of links is much greater and link flexibility, as well as joint or drive train flexibility, is likely to be significant. Long-reach manipulators will be required for a variety of applications in the Environmental Restoration and Waste Management Program. While each application will present specific functional, kinematic, and performance requirements, an approach for determining the kinematic applicability and performance characteristics is presented, with a focus on waste storage tank remediation. Requirements are identified, kinematic configurations are considered, and a parametric study of link design parameters and their effects on performance characteristics is presented

  3. Using Facebook to Reach People Who Experience Auditory Hallucinations

    OpenAIRE

    Crosier, Benjamin Sage; Brian, Rachel Marie; Ben-Zeev, Dror

    2016-01-01

    Background Auditory hallucinations (eg, hearing voices) are relatively common and underreported false sensory experiences that may produce distress and impairment. A large proportion of those who experience auditory hallucinations go unidentified and untreated. Traditional engagement methods oftentimes fall short in reaching the diverse population of people who experience auditory hallucinations. Objective The objective of this proof-of-concept study was to examine the viability of leveraging...

  4. Developing human health exposure scenarios for petroleum substances under REACH

    Energy Technology Data Exchange (ETDEWEB)

    Carter, M.; De Wilde, P.; Maksimainen, K.; Margary, A.; Money, C.; Pizzella, G.; Svanehav, T.; Tsang, W.; Urbanus, J.; Rohde, A.

    2012-12-15

    This report describes the approaches that were adopted by CONCAWE to prepare the human exposure estimates in the chemical safety assessments of the REACH registration dossiers for petroleum substances based on all applicable regulatory guidance. Separate exposure estimates were developed for workers and for consumers and included inhalation and dermal routes. The complex nature of petroleum substances required various scientifically justified refinements of the regulatory guidance.

  5. The processing of visual and auditory information for reaching movements.

    Science.gov (United States)

    Glazebrook, Cheryl M; Welsh, Timothy N; Tremblay, Luc

    2016-09-01

    Presenting target and non-target information in different modalities influences target localization if the non-target is within the spatiotemporal limits of perceptual integration. When using auditory and visual stimuli, the influence of a visual non-target on auditory target localization is greater than the reverse. It is not known, however, whether or how such perceptual effects extend to goal-directed behaviours. To gain insight into how audio-visual stimuli are integrated for motor tasks, the kinematics of reaching movements towards visual or auditory targets with or without a non-target in the other modality were examined. When present, the simultaneously presented non-target could be spatially coincident, to the left, or to the right of the target. Results revealed that auditory non-targets did not influence reaching trajectories towards a visual target, whereas visual non-targets influenced trajectories towards an auditory target. Interestingly, the biases induced by visual non-targets were present early in the trajectory and persisted until movement end. Subsequent experimentation indicated that the magnitude of the biases was equivalent whether participants performed a perceptual or motor task, whereas variability was greater for the motor versus the perceptual tasks. We propose that visually induced trajectory biases were driven by the perceived mislocation of the auditory target, which in turn affected both the movement plan and subsequent control of the movement. Such findings provide further evidence of the dominant role visual information processing plays in encoding spatial locations as well as planning and executing reaching action, even when reaching towards auditory targets.

  6. International reach of tobacco marketing among young children.

    Science.gov (United States)

    Borzekowski, Dina L G; Cohen, Joanna E

    2013-10-01

    Prosmoking messages, delivered through marketing and the media, can reach very young children and influence attitudes and behaviors around smoking. This study examined the reach of tobacco marketing to 5 and 6 year olds in 6 low- and middle-income countries. Researchers worked one-on-one with 5 and 6 year olds in Brazil, China, India, Nigeria, Pakistan, and Russia (N = 2423). The children were asked to match logos with pictures of products, including 8 logos for cigarette brands. Analyses examined, overall and by country, whether gender, age, location, household use of tobacco, and knowledge of media characters were associated with awareness of cigarette brand logos. Additional analyses considered the relationship between cigarette brand logo awareness and intentions to smoke. Overall, 68% of 5 and 6 year olds could identify at least 1 cigarette brand logo, ranging from 50% in Russia to 86% in China. Across countries, being slightly older and having someone in the household who used tobacco, were significantly associated with greater odds of being able to identify at least 1 cigarette brand logo. The majority of young children from low- and middle-income countries are familiar with cigarette brands. This study's findings suggest that more effective measures are needed to restrict the reach of tobacco marketing.

  7. Do older adults perceive postural constraints for reach estimation?

    Science.gov (United States)

    Cordova, Alberto; Gabbard, Carl

    2014-01-01

    BACKGROUND/STUDY CONTEXT: Recent evidence indicates that older persons have difficulty mentally representing intended movements. Furthermore, in an estimation of reach paradigm using motor imagery, a form of mental representation, older persons significantly overestimated their ability compared with young adults. The authors tested the notion that older adults may also have difficulty perceiving the postural constraints associated with reach estimation. The authors compared young (Mage = 22 years) and older (Mage = 67) adults on reach estimation while seated and in a more postural demanding standing and leaning forward position. The expectation was a significant postural effect with the standing condition, as evidenced by reduced overestimation. Whereas there was no difference between groups in the seated condition (both overestimated), older adults underestimated whereas the younger group once again overestimated in the standing condition. From one perspective, these results show that older adults do perceive postural constraints in light of their own physical capabilities. That is, that group perceived greater postural demands with the standing posture and elected to program a more conservative strategy, resulting in underestimation.

  8. Distractor interference during a choice limb reaching task.

    Directory of Open Access Journals (Sweden)

    Matthew Ray

    Full Text Available According to action-centered models of attention, the patterns of distractor interference that emerge in selective reaching tasks are related to the time and effort required to resolve a race for activation between competing target and non-target response producing processes. Previous studies have only used unimanual aiming tasks and, as such, only examined the effects of competition that occurs within a limb. The results of studies using unimanual aiming movements often reveal an "ipsilateral effect"--distractors on the same side of space as the effector cause greater interference than distractors on the opposite side of space. The cost of the competition when response selection is between the limbs has yet to be addressed. Participants in the present study executed reaching movements to 1 of 4 (2 left, 2 right possible target locations with and without a distractor. Participants made ipsilateral reaches (left hand to left targets, right hand to right targets. In contrast to studies using unimanual aiming movements, a "contralateral effect" was observed; distractors affording responses for the other hand (in contralateral space caused more interference than distractors affording responses for the same hand. The findings from the present research demonstrate that when certain portions of response planning must be resolved prior to response initiation, distractors that code for that dimension cause the greatest interference.

  9. The necessary and sufficient conditions of therapeutic personality change: Reactions to Rogers' 1957 article.

    Science.gov (United States)

    Samstag, Lisa Wallner

    2007-09-01

    Carl Rogers' article (see record 2007-14639-002) on the necessary and sufficient conditions for personality change has had a significant impact on the field of psychotherapy and psychotherapy research. He emphasized the client as arbiter of his or her own subjective experience and tested his hypothesized therapist-offered conditions of change using recorded sessions. This aided in demystifying the therapeutic process and led to a radical shift in the listening stance of the therapist. I briefly outline my views regarding the influence of the ideas presented in this work, describe the intellectual and cultural context of the times, and discuss a number of ways in which the therapist-offered conditions for psychological transformation are neither necessary nor sufficient. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  10. A Sufficient Condition on Convex Relaxation of AC Optimal Power Flow in Distribution Networks

    DEFF Research Database (Denmark)

    Huang, Shaojun; Wu, Qiuwei; Wang, Jianhui

    2016-01-01

    This paper proposes a sufficient condition for the convex relaxation of AC Optimal Power Flow (OPF) in radial distribution networks as a second order cone program (SOCP) to be exact. The condition requires that the allowed reverse power flow is only reactive or active, or none. Under the proposed...... solution of the SOCP can be converted to an optimal solution of the original AC OPF. The efficacy of the convex relaxation to solve the AC OPF is demonstrated by case studies of an optimal multi-period planning problem of electric vehicles (EVs) in distribution networks....... sufficient condition, the feasible sub-injection region (power injections of nodes excluding the root node) of the AC OPF is convex. The exactness of the convex relaxation under the proposed condition is proved through constructing a group of monotonic series with limits, which ensures that the optimal...

  11. Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains

    DEFF Research Database (Denmark)

    Tataru, Paula Cristina; Hobolth, Asger

    2011-01-01

    past evolutionary events (exact times and types of changes) are unaccessible and the past must be inferred from DNA sequence data observed in the present. RESULTS: We describe and implement three algorithms for computing linear combinations of expected values of the sufficient statistics, conditioned......BACKGROUND: Continuous time Markov chains (CTMCs) is a widely used model for describing the evolution of DNA sequences on the nucleotide, amino acid or codon level. The sufficient statistics for CTMCs are the time spent in a state and the number of changes between any two states. In applications...... of the algorithms is available at www.birc.au.dk/~paula/. CONCLUSIONS: We use two different models to analyze the accuracy and eight experiments to investigate the speed of the three algorithms. We find that they have similar accuracy and that EXPM is the slowest method. Furthermore we find that UNI is usually...

  12. Why and how to make a REACH registration of combustion ash; Moejligheter vid REACH-registrering av energiaskor

    Energy Technology Data Exchange (ETDEWEB)

    Loevgren, Linnea; Wik, Ola

    2009-10-15

    The new chemical regulation, REACH (1997/2006/EC), Registration, Evaluation, Authorization and restriction of Chemicals, took effect the 1st of June 2007. The background to this report was the introduction of REACH and the difficulties to understand the implications for ash. The most important consequence of REACH is that all chemical substances that are manufactured, handled and used above one tonne per annum per legal entity shall be registered according to this regulation. The registration includes specifying the chemical, physical, toxicity and ecotoxicity properties of the substance and risk assessing the identified areas of use. The report describes the use of ash in connection to the waste legislation and its planned end-of-waste-criteria, the chemical legislation and the Construction Products Directive. The target audience of this report is companies producing ashes and having a use or seeing a use for its ash. The report describes how to make a REACH registration of ash independent if a company did or did not pre-register ash during 2008. It describes how to change from one ash registration into another if the pre-registration was done for one type of ash but the company changes opinion during the sameness check, i.e. changing SIEF (Appendix A). Taking part in REACH registration projects during 2009-2010 can be advantageous since knowledge and financing are shared. Ash can be REACH registered also in the future but it is important to know that the registration have to be done prior the production and marketing starts. If ash is consider to be a waste the handling is covered by the community and national waste legislation. In Sweden ashes are by and large being regarded as waste, and recycling is risk assessed and permits are given case by case. End-of-waste criteria for different waste material are being elaborated within the EU. Such criteria will among other details cover chemical safety. When a material fulfils the end-of-waste criteria such material

  13. The degree of C0-sufficiency of analytic function germs with respect to an ideal

    International Nuclear Information System (INIS)

    Pham Tien Son

    2006-07-01

    Let f:(C 2 , 0) → (C, 0) be an analytic function germ of two complex variables and let I be an ideal of C{x,y). We give some formulae for the degree of C 0 -sufficiency of f with respect to I. When I is the maximal ideal we retrieve a result of T.C. Kuo and Y.C. Lu. (author)

  14. Maximizing Health or Sufficient Capability in Economic Evaluation? A Methodological Experiment of Treatment for Drug Addiction.

    Science.gov (United States)

    Goranitis, Ilias; Coast, Joanna; Day, Ed; Copello, Alex; Freemantle, Nick; Frew, Emma

    2017-07-01

    Conventional practice within the United Kingdom and beyond is to conduct economic evaluations with "health" as evaluative space and "health maximization" as the decision-making rule. However, there is increasing recognition that this evaluative framework may not always be appropriate, and this is particularly the case within public health and social care contexts. This article presents a methodological case study designed to explore the impact of changing the evaluative space within an economic evaluation from health to capability well-being and the decision-making rule from health maximization to the maximization of sufficient capability. Capability well-being is an evaluative space grounded on Amartya Sen's capability approach and assesses well-being based on individuals' ability to do and be the things they value in life. Sufficient capability is an egalitarian approach to decision making that aims to ensure everyone in society achieves a normatively sufficient level of capability well-being. The case study is treatment for drug addiction, and the cost-effectiveness of 2 psychological interventions relative to usual care is assessed using data from a pilot trial. Analyses are undertaken from a health care and a government perspective. For the purpose of the study, quality-adjusted life years (measured using the EQ-5D-5L) and years of full capability equivalent and years of sufficient capability equivalent (both measured using the ICECAP-A [ICEpop CAPability measure for Adults]) are estimated. The study concludes that different evaluative spaces and decision-making rules have the potential to offer opposing treatment recommendations. The implications for policy makers are discussed.

  15. On necessary and sufficient conditions for some Higgs potentials to be bounded from below

    International Nuclear Information System (INIS)

    Klimenko, K.G.

    1984-01-01

    The necessary and sufficient (NS) conditions have been obtained to make the Higgs potentials be bounded from below. Here these potentials are constructed from: (i) two doublets, as well as two doublets and a singlet of SU(2)-group; (ii) adjoint and vector representations of SO(n). For the potential constructed from the adjoint and fundamental SU(n) multiplets, the problem of NS conditions is solved partially

  16. Retrocausal Effects as a Consequence of Quantum Mechanics Refined to Accommodate the Principle of Sufficient Reason

    Energy Technology Data Exchange (ETDEWEB)

    Stapp, Henry P.

    2011-05-10

    The principle of sufficient reason asserts that anything that happens does so for a reason: no definite state of affairs can come into being unless there is a sufficient reason why that particular thing should happen. This principle is usually attributed to Leibniz, although the first recorded Western philosopher to use it was Anaximander of Miletus. The demand that nature be rational, in the sense that it be compatible with the principle of sufficient reason, conflicts with a basic feature of contemporary orthodox physical theory, namely the notion that nature's response to the probing action of an observer is determined by pure chance, and hence on the basis of absolutely no reason at all. This appeal to pure chance can be deemed to have no rational fundamental place in reason-based Western science. It is argued here, on the basis of the other basic principles of quantum physics, that in a world that conforms to the principle of sufficient reason, the usual quantum statistical rules will naturally emerge at the pragmatic level, in cases where the reason behind nature's choice of response is unknown, but that the usual statistics can become biased in an empirically manifest way when the reason for the choice is empirically identifiable. It is shown here that if the statistical laws of quantum mechanics were to be biased in this way then the basically forward-in-time unfolding of empirical reality described by orthodox quantum mechanics would generate the appearances of backward-time-effects of the kind that have been reported in the scientific literature.

  17. Sufficient condition for generation of multiple solidification front in one-dimensional solidification of binary alloys

    International Nuclear Information System (INIS)

    Bobula, E.; Kalicka, Z.

    1981-10-01

    In the paper we consider the one-dimensional solidification of binary alloys in the finite system. The authors present the sufficient condition for solidification in the liquid in front of the moving solid-liquid interface. The effect may produce a fluctuating concentration distributin in the solid. The convection in the liquid and supercooling required for homogeneous nucleation are omitted. A local-equilibrium approximation at the liquid-solid interface is supposed. (author)

  18. A sufficiency property arising from the characterization of extremes of Markov chains

    OpenAIRE

    Bortot, Paola; Coles, Stuart

    2000-01-01

    At extreme levels, it is known that for a particular choice of marginal distribution, transitions of a Markov chain behave like a random walk. For a broad class of Markov chains, we give a characterization for the step length density of the limiting random walk, which leads to an interesting sufficiency property. This representation also leads us to propose a new technique for kernel density estimation for this class of models.

  19. Children's Sleep Needs: Is There Sufficient Evidence to Recommend Optimal Sleep for Children?

    OpenAIRE

    Matricciani, Lisa; Blunden, Sarah; Rigney, Gabrielle; Williams, Marie T.; Olds, Tim S.

    2013-01-01

    It is widely recognized that sleep is important for children's health and well-being and that short sleep duration is associated with a wide range of negative health outcomes. Recently, there has been much interest in whether or not there are sufficient data to support the specific recommendations made for how much sleep children need. In this article we explore concepts related to children's sleep need, discuss the theory, rationale, and empirical evidence for contemporary sleep recommendati...

  20. Retrocausal Effects as a Consequence of Quantum Mechanics Refined to Accommodate the Principle of Sufficient Reason

    International Nuclear Information System (INIS)

    Stapp, Henry P.

    2011-01-01

    The principle of sufficient reason asserts that anything that happens does so for a reason: no definite state of affairs can come into being unless there is a sufficient reason why that particular thing should happen. This principle is usually attributed to Leibniz, although the first recorded Western philosopher to use it was Anaximander of Miletus. The demand that nature be rational, in the sense that it be compatible with the principle of sufficient reason, conflicts with a basic feature of contemporary orthodox physical theory, namely the notion that nature's response to the probing action of an observer is determined by pure chance, and hence on the basis of absolutely no reason at all. This appeal to pure chance can be deemed to have no rational fundamental place in reason-based Western science. It is argued here, on the basis of the other basic principles of quantum physics, that in a world that conforms to the principle of sufficient reason, the usual quantum statistical rules will naturally emerge at the pragmatic level, in cases where the reason behind nature's choice of response is unknown, but that the usual statistics can become biased in an empirically manifest way when the reason for the choice is empirically identifiable. It is shown here that if the statistical laws of quantum mechanics were to be biased in this way then the basically forward-in-time unfolding of empirical reality described by orthodox quantum mechanics would generate the appearances of backward-time-effects of the kind that have been reported in the scientific literature.

  1. MSEBAG: a dynamic classifier ensemble generation based on `minimum-sufficient ensemble' and bagging

    Science.gov (United States)

    Chen, Lei; Kamel, Mohamed S.

    2016-01-01

    In this paper, we propose a dynamic classifier system, MSEBAG, which is characterised by searching for the 'minimum-sufficient ensemble' and bagging at the ensemble level. It adopts an 'over-generation and selection' strategy and aims to achieve a good bias-variance trade-off. In the training phase, MSEBAG first searches for the 'minimum-sufficient ensemble', which maximises the in-sample fitness with the minimal number of base classifiers. Then, starting from the 'minimum-sufficient ensemble', a backward stepwise algorithm is employed to generate a collection of ensembles. The objective is to create a collection of ensembles with a descending fitness on the data, as well as a descending complexity in the structure. MSEBAG dynamically selects the ensembles from the collection for the decision aggregation. The extended adaptive aggregation (EAA) approach, a bagging-style algorithm performed at the ensemble level, is employed for this task. EAA searches for the competent ensembles using a score function, which takes into consideration both the in-sample fitness and the confidence of the statistical inference, and averages the decisions of the selected ensembles to label the test pattern. The experimental results show that the proposed MSEBAG outperforms the benchmarks on average.

  2. Staple Food Self-Sufficiency of Farmers Household Level in The Great Solo

    Science.gov (United States)

    Darsono

    2017-04-01

    Analysis of food security level of household is a novelty of measurement standards which usually includes regional and national levels. With household approach is expected to provide the basis of sharp food policy formulation. The purpose of this study are to identify the condition of self-sufficiency in staple foods, and to find the main factors affecting the dynamics of self-sufficiency in staple foods on farm household level in Great Solo. Using primary data from 50 farmers in the sample and secondary data in Great Solo (Surakarta city, Boyolali, Sukoharjo, Karanganyar, Wonogiri, Sragen and Klaten). Compiled panel data were analyzed with linear probability regression models to produce a good model. The results showed that farm households in Great Solo has a surplus of staple food (rice) with an average consumption rate of 96.8 kg/capita/year. This number is lower than the national rate of 136.7 kg/capita/year. The main factors affecting the level of food self-sufficiency in the farmer household level are: rice production, rice consumption, land tenure, and number of family members. Key recommendations from this study are; improvement scale of the land cultivation for rice farming and non-rice diversification consumption.

  3. Navigating behavioral energy sufficiency. Results from a survey in Swiss cities on potential behavior change.

    Science.gov (United States)

    Seidl, Roman; Moser, Corinne; Blumer, Yann

    2017-01-01

    Many countries have some kind of energy-system transformation either planned or ongoing for various reasons, such as to curb carbon emissions or to compensate for the phasing out of nuclear energy. One important component of these transformations is the overall reduction in energy demand. It is generally acknowledged that the domestic sector represents a large share of total energy consumption in many countries. Increased energy efficiency is one factor that reduces energy demand, but behavioral approaches (known as "sufficiency") and their respective interventions also play important roles. In this paper, we address citizens' heterogeneity regarding both their current behaviors and their willingness to realize their sufficiency potentials-that is, to reduce their energy consumption through behavioral change. We collaborated with three Swiss cities for this study. A survey conducted in the three cities yielded thematic sets of energy-consumption behavior that various groups of participants rated differently. Using this data, we identified four groups of participants with different patterns of both current behaviors and sufficiency potentials. The paper discusses intervention types and addresses citizens' heterogeneity and behaviors from a city-based perspective.

  4. Sonic hedgehog in the notochord is sufficient for patterning of the intervertebral discs.

    Science.gov (United States)

    Choi, Kyung-Suk; Lee, Chanmi; Harfe, Brian D

    2012-01-01

    The intervertebral discs, located between adjacent vertebrae, are required for stability of the spine and distributing mechanical load throughout the vertebral column. All cell types located in the middle regions of the discs, called nuclei pulposi, are derived from the embryonic notochord. Recently, it was shown that the hedgehog signaling pathway plays an essential role during formation of nuclei pulposi. However, during the time that nuclei pulposi are forming, Shh is expressed in both the notochord and the nearby floor plate. To determine the source of SHH protein sufficient for formation of nuclei pulposi we removed Shh from either the floor plate or the notochord using tamoxifen-inducible Cre alleles. Removal of Shh from the floor plate resulted in phenotypically normal intervertebral discs, indicating that Shh expression in this tissue is not required for disc patterning. In addition, embryos that lacked Shh in the floor plate had normal vertebral columns, demonstrating that Shh expression in the notochord is sufficient for pattering the entire vertebral column. Removal of Shh from the notochord resulted in the absence of Shh in the floor plate, loss of intervertebral discs and vertebral structures. These data indicate that Shh expression in the notochord is sufficient for patterning of the intervertebral discs and the vertebral column. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  5. Redox self-sufficient whole cell biotransformation for amination of alcohols.

    Science.gov (United States)

    Klatte, Stephanie; Wendisch, Volker F

    2014-10-15

    Whole cell biotransformation is an upcoming tool to replace common chemical routes for functionalization and modification of desired molecules. In the approach presented here the production of various non-natural (di)amines was realized using the designed whole cell biocatalyst Escherichia coli W3110/pTrc99A-ald-adh-ta with plasmid-borne overexpression of genes for an l-alanine dehydrogenase, an alcohol dehydrogenase and a transaminase. Cascading alcohol oxidation with l-alanine dependent transamination and l-alanine dehydrogenase allowed for redox self-sufficient conversion of alcohols to the corresponding amines. The supplementation of the corresponding (di)alcohol precursors as well as amino group donor l-alanine and ammonium chloride were sufficient for amination and redox cofactor recycling in a resting buffer system. The addition of the transaminase cofactor pyridoxal-phosphate and the alcohol dehydrogenase cofactor NAD(+) was not necessary to obtain complete conversion. Secondary and cyclic alcohols, for example, 2-hexanol and cyclohexanol were not aminated. However, efficient redox self-sufficient amination of aliphatic and aromatic (di)alcohols in vivo was achieved with 1-hexanol, 1,10-decanediol and benzylalcohol being aminated best. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Refueling availability for alternative fuel vehicle markets: Sufficient urban station coverage

    International Nuclear Information System (INIS)

    Melaina, Marc; Bremson, Joel

    2008-01-01

    Alternative fuel vehicles can play an important role in addressing the challenges of climate change, energy security, urban air pollution and the continued growth in demand for transportation services. The successful commercialization of alternative fuels for vehicles is contingent upon a number of factors, including vehicle cost and performance. Among fuel infrastructure issues, adequate refueling availability is one of the most fundamental to successful commercialization. A commonly cited source reports 164,300 refueling stations in operation nationwide. However, from the perspective of refueling availability, this nationwide count tends to overstate the number of stations required to support the widespread deployment of alternative fuel vehicles. In terms of spatial distribution, the existing gasoline station networks in many urban areas are more than sufficient. We characterize a sufficient level of urban coverage based upon a subset of cities served by relatively low-density station networks, and estimate that some 51,000 urban stations would be required to provide this sufficient level of coverage to all major urban areas, 33 percent less than our estimate of total urban stations. This improved characterization will be useful for engineering, economic and policy analyses. (author)

  7. FOOD SELF-SUFFICIENCY OF THE EUROPEAN UNION COUNTRIES – ENERGETIC APPROACH

    Directory of Open Access Journals (Sweden)

    Arkadiusz Sadowski

    2016-06-01

    Full Text Available The paper covers the issues of a basic social need, namely alimentation. The aim of the research is to evaluate the energetic food self-sufficiency and its changes in the European Union countries. The research has been conducted using the author’s methodology basing on the amount of energy produced and consumed in 1990-2009. The analyses proved that within the considered period, the European Union became an importer of net energy comprised in agricultural products. The excess in produced energy was mainly observed by the countries of European lowland. Moreover in most of the countries, a decrease in the analyzed factor was observed when compared with the 1990-1999 period. On the other hand, in relation to the new member states the increase in food energetic self-sufficiency was observed. The conclusion has been drawn that, while the general food self-sufficiency is mainly determined by environmental factors, its dynamics is primarily influenced by the factors connected with agricultural policy.

  8. Vestibular feedback maintains reaching accuracy during body movement

    Science.gov (United States)

    Reynolds, Raymond F.

    2016-01-01

    Key points Reaching movements can be perturbed by vestibular input, but the function of this response is unclear.Here, we applied galvanic vestibular stimulation concurrently with real body movement while subjects maintained arm position either fixed in space or fixed with respect to their body.During the fixed‐in‐space conditions, galvanic vestibular stimulation caused large changes in arm trajectory consistent with a compensatory response to maintain upper‐limb accuracy in the face of body movement.Galvanic vestibular stimulation responses were absent during the body‐fixed task, demonstrating task dependency in vestibular control of the upper limb.The results suggest that the function of vestibular‐evoked arm movements is to maintain the accuracy of the upper limb during unpredictable body movement, but only when reaching in an earth‐fixed reference frame. Abstract When using our arms to interact with the world, unintended body motion can introduce movement error. A mechanism that could detect and compensate for such motion would be beneficial. Observations of arm movements evoked by vestibular stimulation provide some support for this mechanism. However, the physiological function underlying these artificially evoked movements is unclear from previous research. For such a mechanism to be functional, it should operate only when the arm is being controlled in an earth‐fixed rather than a body‐fixed reference frame. In the latter case, compensation would be unnecessary and even deleterious. To test this hypothesis, subjects were gently rotated in a chair while being asked to maintain their outstretched arm pointing towards either earth‐fixed or body‐fixed memorized targets. Galvanic vestibular stimulation was applied concurrently during rotation to isolate the influence of vestibular input, uncontaminated by inertial factors. During the earth‐fixed task, galvanic vestibular stimulation produced large polarity‐dependent corrections in arm

  9. Optical fiber reach extended FMCW radar for remote respiratory tracking

    DEFF Research Database (Denmark)

    Suhr, Lau Frejstrup; Tafur Monroy, Idelfonso; Vegas Olmos, Juan José

    2017-01-01

    Wireless monitoring of human vital signs such as breathing rate is a nonintrusive alternative to contemporary solutions relying on physical contact. To ease the installment, fiber optical transmission is used to extend the reach from the transmitter and receiver circuitry to the antenna subsystem....... In this paper, a frequency modulated carrier wave radar, operating at 25.7–26.6 GHz and utilizing optical fiber extension, was experimentally demonstrated to accurately recover the breathing rate of a human placed 1 m away from the radar antennas....

  10. Family (oikos Evangelism for reaching forward caste Hindus in India

    Directory of Open Access Journals (Sweden)

    DW Fowlkes

    2006-09-01

    Full Text Available This article acknowledges the need for Church Planting Movements among the unreached peoples of India. Of particular concern to this study is the application of Church Planting Movement strategy to forward caste Hindus of India. It is shown that evangelizing households (family or �oikos� evangelism is a New Testament strategy and the most appropriate strategy for reaching forward caste Hindus. It is concluded that Christian disciples remaining within Hindu culture and familial systems hold the potential for the most indigenous approach to evangelizing forward caste Hindus.

  11. THE REACH OF TWITTER AS A POLITICAL TOOL

    Directory of Open Access Journals (Sweden)

    Vanessa González Mendoza

    2010-07-01

    Full Text Available The massive growth of Internet and all the possibilities that it offers, have made us beings of instant gratification. The need to know, to be informed, and to communicate at all times, stands above many other things, and rules our daily life. Tools like Twitter provide the citizen a way in which they can express their ideas, either to be heard or to make a change even in the political atmosphere. This article searches to determine the influence and the reach of Twitter in the political activism of a country.

  12. Interaction torque contributes to planar reaching at slow speed

    Directory of Open Access Journals (Sweden)

    Hoshi Fumihiko

    2008-10-01

    Full Text Available Abstract Background How the central nervous system (CNS organizes the joint dynamics for multi-joint movement is a complex problem, because of the passive interaction among segmental movements. Previous studies have demonstrated that the CNS predictively compensates for interaction torque (INT which is arising from the movement of the adjacent joints. However, most of these studies have mainly examined quick movements, presumably because the current belief is that the effects of INT are not significant at slow speeds. The functional contribution of INT for multijoint movements performed in various speeds is still unclear. The purpose of this study was to examine the contribution of INT to a planer reaching in a wide range of motion speeds for healthy subjects. Methods Subjects performed reaching movements toward five targets under three different speed conditions. Joint position data were recorded using a 3-D motion analysis device (50 Hz. Torque components, muscle torque (MUS, interaction torque (INT, gravity torque (G, and net torque (NET were calculated by solving the dynamic equations for the shoulder and elbow. NET at a joint which produces the joint kinematics will be an algebraic sum of torque components; NET = MUS - G - INT. Dynamic muscle torque (DMUS = MUS-G was also calculated. Contributions of INT impulse and DMUS impulse to NET impulse were examined. Results The relative contribution of INT to NET was not dependent on speed for both joints at every target. INT was additive (same direction to DMUS at the shoulder joint, while in the elbow DMUS counteracted (opposed to INT. The trajectory of reach was linear and two-joint movements were coordinated with a specific combination at each target, regardless of motion speed. However, DMUS at the elbow was opposed to the direction of elbow movement, and its magnitude varied from trial to trial in order to compensate for the variability of INT. Conclusion Interaction torque was important at

  13. Access and Attitudes to HPV Vaccination amongst Hard-To-Reach Populations in Kenya.

    Directory of Open Access Journals (Sweden)

    Deborah Watson-Jones

    Full Text Available Sub-Saharan Africa bears the greatest burden of cervical cancer. Human papillomavirus (HPV vaccination programmes to prevent the disease will need to reach vulnerable girls who may not be able access health and screening services in the future. We conducted formative research on facilitators and barriers to HPV vaccination and potential acceptability of a future HPV vaccination programme amongst girls living in hard-to-reach populations in Kenya.Stakeholder interviews with Ministry of Health staff explored barriers to and support for the uptake of HPV vaccination. A situation assessment was conducted to assess community services in Maasai nomadic pastoralist communities in Kajiado County and in Korogocho informal settlement in Nairobi city, followed by focus group discussions (n=14 and semi-structured interviews (n=28 with health workers, parents, youth, and community and religious leaders. These covered marriage, knowledge of cervical cancer and HPV, factors that might inhibit or support HPV vaccine uptake and intention to accept HPV vaccine if a programme was in place.Reported challenges to an HPV vaccination programme included school absenteeism and drop-out, early age of sex and marriage, lack of parental support, population mobility and distance from services. Despite little prior knowledge of cervical cancer and HPV, communities were interested in receiving HPV vaccination. Adequate social mobilisation and school-based vaccination, supplemented by out-reach activities, were considered important facilitating factors to achieve high coverage. There was some support for a campaign approach to vaccine delivery.Given the high level of support for a vaccine against cervical cancer and the experience of reaching pastoralist and slum-dwellers for other immunizations, implementing an HPV vaccine programme should be feasible in such hard-to-reach communities. This may require additional delivery strategies in addition to the standard school

  14. Effects of accuracy constraints on reach-to-grasp movements in cerebellar patients.

    Science.gov (United States)

    Rand, M K; Shimansky, Y; Stelmach, G E; Bracha, V; Bloedel, J R

    2000-11-01

    Reach-to-grasp movements of patients with pathology restricted to the cerebellum were compared with those of normal controls. Two types of paradigms with different accuracy constraints were used to examine whether cerebellar impairment disrupts the stereotypic relationship between arm transport and grip aperture and whether the variability of this relationship is altered when greater accuracy is required. The movements were made to either a vertical dowel or to a cross bar of a small cross. All subjects were asked to reach for either target at a fast but comfortable speed, grasp the object between the index finger and thumb, and lift it a short distance off the table. In terms of the relationship between arm transport and grip aperture, the control subjects showed a high consistency in grip aperture and wrist velocity profiles from trial to trial for movements to both the dowel and the cross. The relationship between the maximum velocity of the wrist and the time at which grip aperture was maximal during the reach was highly consistent throughout the experiment. In contrast, the time of maximum grip aperture and maximum wrist velocity of the cerebellar patients was quite variable from trial to trial, and the relationship of these measurements also varied considerably. These abnormalities were present regardless of the accuracy requirement. In addition, the cerebellar patients required a significantly longer time to grasp and lift the objects than the control subjects. Furthermore, the patients exhibited a greater grip aperture during reach than the controls. These data indicate that the cerebellum contributes substantially to the coordination of movements required to perform reach-to-grasp movements. Specifically, the cerebellum is critical for executing this behavior with a consistent, well-timed relationship between the transport and grasp components. This contribution is apparent even when accuracy demands are minimal.

  15. Input shaping methods for telerobotic operation of flexible, long-reach manipulators

    International Nuclear Information System (INIS)

    Kwon, Dong-Soo; Hwang, Dong-Hwan; Babcock, S.M.

    1994-01-01

    Among the Environmental Restoration and Waste Management Program of the U.S. Department of Energy, the remediation of radioactive waste from the underground storage tank challenges the state-of-the-art equipment and methods. Long-reach manipulators are being considered to be one of the most advantageous approaches for the retrieval of waste from large storage tanks. Because of long-reach manipulator's high payload capacity and high length-to-cross-section ratios, such manipulator system exhibits significant structural flexibility. To avoid structural vibrations during operation, control algorithms employing various types of shaping filters were investigated. A robust notch filtering method and an impulse shaping method were evaluated. In addition to that, a new approach that uses imbedded simulation was developed and compared with others. In the new approach, joint trajectories have been generated considering the flexible link dynamics

  16. Is there sufficient evidence regarding signage-based stair use interventions? A sequential meta-analysis.

    Science.gov (United States)

    Bauman, Adrian; Milton, Karen; Kariuki, Maina; Fedel, Karla; Lewicka, Mary

    2017-11-28

    The proliferation of studies using motivational signs to promote stair use continues unabated, with their oft-cited potential for increasing population-level physical activity participation. This study examined all stair use promotional signage studies since 1980, calculating pre-estimates and post-estimates of stair use. The aim of this project was to conduct a sequential meta-analysis to pool intervention effects, in order to determine when the evidence base was sufficient for population-wide dissemination. Using comparable data from 50 stair-promoting studies (57 unique estimates) we pooled data to assess the effect sizes of such interventions. At baseline, median stair usage across interventions was 8.1%, with an absolute median increase of 2.2% in stair use following signage-based interventions. The overall pooled OR indicated that participants were 52% more likely to use stairs after exposure to promotional signs (adjusted OR 1.52, 95% CI 1.37 to 1.70). Incremental (sequential) meta-analyses using z-score methods identified that sufficient evidence for stair use interventions has existed since 2006, with recent studies providing no further evidence on the effect sizes of such interventions. This analysis has important policy and practice implications. Researchers continue to publish stair use interventions without connection to policymakers' needs, and few stair use interventions are implemented at a population level. Researchers should move away from repeating short-term, small-scale, stair sign interventions, to investigating their scalability, adoption and fidelity. Only such research translation efforts will provide sufficient evidence of external validity to inform their scaling up to influence population physical activity. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  17. Complete self-sufficiency planning: designing and building disaster-ready hospitals.

    Science.gov (United States)

    Brands, Chad K; Hernandez, Raquel G; Stenberg, Arnold; Carnes, Gary; Ellen, Jonathan; Epstein, Michael; Strouse, Timothy

    2013-01-01

    The need for healthcare systems and academic medical centers to be optimally prepared in the event of a disaster is well documented. Events such as Hurricane Katrina demonstrate a major gap in disaster preparedness for at-risk medical institutions. To address this gap, we outline the components of complete self-sufficiency planning in designing and building hospitals that will function at full operational capacity in the event of a disaster. We review the processes used and outcomes achieved in building a new critical access, freestanding children's hospital in Florida. Given that hurricanes are the most frequently occurring natural disaster in Florida, the executive leadership of our hospital determined that we should be prepared for worst-case scenarios in the design and construction of a new hospital. A comprehensive vulnerability assessment was performed. A building planning process that engaged all of the stakeholders was used during the planning and design phases. Subsequent executive-level review and discussions determined that a disaster would require the services of a fully functional hospital. Lessons learned from our own institution's previous experiences and those of medical centers involved in the Hurricane Katrina disaster were informative and incorporated into an innovative set of hospital design elements used for construction of a new hospital with full operational capacity in a disaster. A freestanding children's hospital was constructed using a new framework for disaster planning and preparedness that we have termed complete self-sufficiency planning. We propose the use of complete self-sufficiency planning as a best practice for disaster preparedness in the design and construction of new hospital facilities.

  18. Virtual water and water self-sufficiency in agricultural and livestock products in Brazil.

    Science.gov (United States)

    da Silva, Vicente de Paulo R; de Oliveira, Sonaly D; Braga, Célia C; Brito, José Ivaldo B; de Sousa, Francisco de Assis S; de Holanda, Romildo M; Campos, João Hugo B C; de Souza, Enio P; Braga, Armando César R; Rodrigues Almeida, Rafaela S; de Araújo, Lincoln E

    2016-12-15

    Virtual water trade is often considered a solution for restricted water availability in many regions of the world. Brazil is the world leader in the production and export of various agricultural and livestock products. The country is either a strong net importer or a strong net exporter of these products. The objective of this study is to determine the volume of virtual water contained in agricultural and livestock products imported/exported by Brazil from 1997 to 2012, and to define the water self-sufficiency index of agricultural and livestock products in Brazil. The indexes of water scarcity (WSI), water dependency (WDI) and water self-sufficiency (WSSI) were calculated for each Brazilian state. These indexes and the virtual water balance were calculated following the methodology developed by Chapagain and Hoekstra (2008) and Hoekstra and Hung (2005). The total water exports and imports embedded in agricultural and livestock products were 5.28 × 10 10 and 1.22 × 10 10  Gm 3  yr -1 , respectively, which results in positive virtual water balance of 4.05 × 10 10  Gm 3  yr -1 . Brazil is either a strong net importer or a strong net exporter of agricultural and livestock products among the Mercosur countries. Brazil has a positive virtual water balance of 1.85 × 10 10  Gm 3  yr -1 . The indexes used in this study reveal that Brazil is self-sufficient in food production, except for a few products such as wheat and rice. Horticultural products (tomato, onion, potato, cassava and garlic) make up a unique product group with negative virtual water balance in Brazil. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Energy self-sufficient sensory ball screw drive; Energieautarker sensorischer Kugelgewindetrieb

    Energy Technology Data Exchange (ETDEWEB)

    Bertram, Oliver

    2012-07-01

    Nowadays the availability of machine tools plays a decisive role in competition to increase in productivity. From state of the art it arises, that ball screw drives are the most abusive component in feed drives because of abrasive wear. Furthermore condition monitoring enables avoiding unplanned machine failure and increasing the availability of the deployed production facility. Thereby the application of additional sensors allows the direct acquisition of wear correlative measurements. To reduce the required effort for integration and increase the robustness, reliability and clarity in industrial environment energy self-sufficient sensor systems can be applied. In this thesis the development and investigation of an energy self-sufficient sensory ball screw drive with direct measurement of wear correlative pretension for condition monitoring application is described. The prototype measures the pretension with force sensors based on strain gauges. The sensor system includes microcontroller-based electronics for signal processing as well as wireless data transmission with ZigBee-standard. A hybrid system assures the energy supply of the sensor system. On the one hand a stepper motor generator produces electrical energy from the motion energy of the ball screw drive. On the other hand an energy buffer based on super caps is reloaded in stationary position by wireless energy transmission. For verification a prototype system is build up. In measurements the sensory and energetic characteristics of the energy self-sufficient sensor systems are analyzed. Moreover, the functionality of the ball screw drive as well as the signal characteristics of the force sensors are examined for different pretensions. In addition, pretension losses due to wear are established in realized endurance trials, which means that timely maintenance can be planned.

  20. Quantitative model of transport-aperture coordination during reach-to-grasp movements.

    Science.gov (United States)

    Rand, Miya K; Shimansky, Y P; Hossain, Abul B M I; Stelmach, George E

    2008-06-01

    It has been found in our previous studies that the initiation of aperture closure during reach-to-grasp movements occurs when the hand distance to target crosses a threshold that is a function of peak aperture amplitude, hand velocity, and hand acceleration. Thus, a stable relationship between those four movement parameters is observed at the moment of aperture closure initiation. Based on the concept of optimal control of movements (Naslin 1969) and its application for reach-to-grasp movement regulation (Hoff and Arbib 1993), it was hypothesized that the mathematical equation expressing that relationship can be generalized to describe coordination between hand transport and finger aperture during the entire reach-to-grasp movement by adding aperture velocity and acceleration to the above four movement parameters. The present study examines whether this hypothesis is supported by the data obtained in experiments in which young adults performed reach-to-grasp movements in eight combinations of two reach-amplitude conditions and four movement-speed conditions. It was found that linear approximation of the mathematical model described the relationship among the six movement parameters for the entire aperture-closure phase with very high precision for each condition, thus supporting the hypothesis for that phase. Testing whether one mathematical model could approximate the data across all the experimental conditions revealed that it was possible to achieve the same high level of data-fitting precision only by including in the model two additional, condition-encoding parameters and using a nonlinear, artificial neural network-based approximator with two hidden layers comprising three and two neurons, respectively. This result indicates that transport-aperture coordination, as a specific relationship between the parameters of hand transport and finger aperture, significantly depends on the condition-encoding variables. The data from the aperture-opening phase also fit a

  1. Livestock First Reached Southern Africa in Two Separate Events.

    Science.gov (United States)

    Sadr, Karim

    2015-01-01

    After several decades of research on the subject, we now know when the first livestock reached southern Africa but the question of how they got there remains a contentious topic. Debate centres on whether they were brought with a large migration of Khoe-speakers who originated from East Africa; or whether the livestock were traded down-the-line among hunter-gatherer communities; or indeed whether there was a long history of diverse small scale population movements in this part of the world, one or more of which 'infiltrated' livestock into southern Africa. A new analysis of the distribution of stone toolkits from a sizeable sample of sub-equatorial African Later Stone Age sites, coupled with existing knowledge of the distribution of the earliest livestock remains and ceramics vessels, has allowed us to isolate two separate infiltration events that brought the first livestock into southern Africa just over 2000 years ago; one infiltration was along the Atlantic seaboard and another entered the middle reaches of the Limpopo River Basin. These findings agree well with the latest results of genetic research which together indicate that multiple, small-scale infiltrations probably were responsible for bringing the first livestock into southern Africa.

  2. Record reach : ExxonMobil extends its own world record

    Energy Technology Data Exchange (ETDEWEB)

    Wells, P.

    2008-06-15

    Extended reach drilling (ERD) records are now regularly being broken by ExxonMobil Corporation's Sakhalin project on Russia's east coast. In 2008, an oil well on the coast established a new record by achieving a measured depth of 11,680 meters. The well was punched out by a Texas-based drilling company using the world's largest land-based drilling rig. The use of ERD has reduced the capital and operating costs of the project in addition to reducing its environmental impacts. ERD has been used to drill onshore beneath the seafloor and has eliminated the need for additional offshore structure and pipelines. The horizontal reach of the wells has improved productivity while also avoiding disturbing whale migrations in the region. The rig features a 1.5 million pound load capacity, 3000 horsepower draw-works. The top-drive drilling systems were used to transmit real time data to external locations for further evaluation. Oil and gas is also produced from a gravity-based offshore platform. It was concluded that longer wellbore are now being developed by the corporation in order to drill under the Beaufort Sea. 2 figs.

  3. Reaching the hip-hop generation: Final (symposium proceedings) report

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    The goal of this final (closing) report is to capture the flavor of the symposium held March 1 and 2, 1993 in New York City convened by Motivational Educational Entertainment, Inc. (MEE), a black-owned communications research, consulting, and video production company based in Philadelphia, Pennsylvania. The mission of MEE is to understand, reach, and positively affect inner-city youth. Traditional communication approaches from mainstream sources to at-risk youth often don`t account for the unique way youth communicate among themselves and how they relate to the media. This understanding, however, is crucial. To understand youth communication, the people who create and send both entertaining and educational messages to urban youth must be brought into the dialogue. The meeting in New York was intended to provide an important opportunity for senders to meet and evaluate the appropriateness and effectiveness of their messages. In addition, the MEE symposium provided a forum for the continuing public debate about what needs to be done to reach today`s urban teens. Included in this document is a description of symposium goals/objectives, symposium activities, the reaction to and analysis of the symposium, recommendations for future MEE courses of action, and an appendix containing copies of press articles.

  4. Ricin A chain reaches the endoplasmic reticulum after endocytosis

    International Nuclear Information System (INIS)

    Liu Qiong; Zhan Jinbiao; Chen Xinhong; Zheng Shu

    2006-01-01

    Ricin is a potent ribosome inactivating protein and now has been widely used for synthesis of immunotoxins. To target ribosome in the mammalian cytosol, ricin must firstly retrograde transport from the endomembrane system to reach the endoplasmic reticulum (ER) where the ricin A chain (RTA) is recognized by ER components that facilitate its membrane translocation to the cytosol. In the study, the fusion gene of enhanced green fluorescent protein (EGFP)-RTA was expressed with the pET-28a (+) system in Escherichia coli under the control of a T7 promoter. The fusion protein showed a green fluorescence. The recombinant protein can be purified by metal chelated affinity chromatography on a column of NTA. The rabbit anti-GFP antibody can recognize the fusion protein of EGFP-RTA just like the EGFP protein. The cytotoxicity of EGFP-RTA and RTA was evaluated by the MTT assay in HeLa and HEP-G2 cells following fluid-phase endocytosis. The fusion protein had a similar cytotoxicity of RTA. After endocytosis, the subcellular location of the fusion protein can be observed with the laser scanning confocal microscopy and the immuno-gold labeling Electro Microscopy. This study provided important evidence by a visualized way to prove that RTA does reach the endoplasmic reticulum

  5. Recovery of Three Arctic Stream Reaches From Experimental Nutrient Enrichment.

    Science.gov (United States)

    Green, A. C.; Benstead, J. P.; Deegan, L. A.; Peterson, B. J.; Bowden, W. B.; Huryn, A. D.; Slavik, K.; Hershey, A. E.

    2005-05-01

    We examined multi-year patterns in community recovery from experimental low-concentration nutrient (N+P and P only) enrichment in three reaches of two Arctic tundra streams (Kuparuk River and Oksrukuyik Creek) on the North Slope of Alaska (USA). Rates of recovery varied among community components and depended on duration of enrichment (2 to 13 consecutive growing seasons). Biomass and C:P ratio of epilithic algae returned to reference levels rapidly (within 2 years), regardless of enrichment duration. Bryophyte cover, which increased greatly after long-term enrichment (>8 years), recovered to reference levels only after 7 years, when a storm scoured most remnant moss in the recovering reach. Persistence of bryophytes slowed recovery rates of insect taxa that had either been positively (e.g., Ephemerella, most chironomid taxa) or negatively (e.g., Orthocladius rivulorum) affected by this shift in dominant primary producer and its consequence for benthic habitat. Growth of Arctic grayling (adults and young-of-year), the top predator, returned to reference rates within two years. Recovery of these Arctic stream ecosystems from nutrient enrichment was consequently controlled largely by interactions between duration of enrichment and physical disturbance, mediated through physical habitat shifts caused by bryophytes.

  6. Google Hangouts: Leveraging Social Media to Reach the Education Community

    Science.gov (United States)

    Eisenhamer, Bonnie; Summers, Frank; McCallister, Dan; Ryer, Holly

    2015-01-01

    Research shows that educator professional development is most effective when it is sustained and/or when a follow-on component is included to support the learning process. In order to create more comprehensive learning experiences for our workshop participants, the education team at the Space Telescope Science Institute is working collaboratively with scientific staff and other experts to create a follow-on component for our professional development program. The new component utilizes video conferencing platforms, such as Google's Hangouts On Air, to provide educators with content updates and extended learning opportunities in between in-person professional development experiences. The goal is to enhance our professional development program in a cost-effective way while reaching a greater cross-section of educators. Video broadcasts go live on Google+, YouTube, and our website - thus providing access to any user with a web browser. Additionally, the broadcasts are automatically recorded and archived for future viewing on our YouTube channel. This provides educators with anywhere, anytime training that best suits their needs and schedules. This poster will highlight our new Hangouts for educators as well as our cross-departmental efforts to expand the reach of our Hubble Hangouts for the public through a targeted recruitment strategy.

  7. Adaptation to delayed force perturbations in reaching movements.

    Directory of Open Access Journals (Sweden)

    Noa Levy

    Full Text Available Adaptation to deterministic force perturbations during reaching movements was extensively studied in the last few decades. Here, we use this methodology to explore the ability of the brain to adapt to a delayed velocity-dependent force field. Two groups of subjects preformed a standard reaching experiment under a velocity dependent force field. The force was either immediately proportional to the current velocity (Control or lagged it by 50 ms (Test. The results demonstrate clear adaptation to the delayed force perturbations. Deviations from a straight line during catch trials were shifted in time compared to post-adaptation to a non-delayed velocity dependent field (Control, indicating expectation to the delayed force field. Adaptation to force fields is considered to be a process in which the motor system predicts the forces to be expected based on the state that a limb will assume in response to motor commands. This study demonstrates for the first time that the temporal window of this prediction needs not to be fixed. This is relevant to the ability of the adaptive mechanisms to compensate for variability in the transmission of information across the sensory-motor system.

  8. Generalization of unconstrained reaching with hand-weight changes.

    Science.gov (United States)

    Yan, Xiang; Wang, Qining; Lu, Zhengchuan; Stevenson, Ian H; Körding, Konrad; Wei, Kunlin

    2013-01-01

    Studies of motor generalization usually perturb hand reaches by distorting visual feedback with virtual reality or by applying forces with a robotic manipulandum. Whereas such perturbations are useful for studying how the central nervous system adapts and generalizes to novel dynamics, they are rarely encountered in daily life. The most common perturbations that we experience are changes in the weights of objects that we hold. Here, we use a center-out, free-reaching task, in which we can manipulate the weight of a participant's hand to examine adaptation and generalization following naturalistic perturbations. In both trial-by-trial paradigms and block-based paradigms, we find that learning converges rapidly (on a timescale of approximately two trials), and this learning generalizes mostly to movements in nearby directions with a unimodal pattern. However, contrary to studies using more artificial perturbations, we find that the generalization has a strong global component. Furthermore, the generalization is enhanced with repeated exposure of the same perturbation. These results suggest that the familiarity of a perturbation is a major factor in movement generalization and that several theories of the neural control of movement, based on perturbations applied by robots or in virtual reality, may need to be extended by incorporating prior influence that is characterized by the familiarity of the perturbation.

  9. An Inverse Optimal Control Approach to Explain Human Arm Reaching Control Based on Multiple Internal Models.

    Science.gov (United States)

    Oguz, Ozgur S; Zhou, Zhehua; Glasauer, Stefan; Wollherr, Dirk

    2018-04-03

    Human motor control is highly efficient in generating accurate and appropriate motor behavior for a multitude of tasks. This paper examines how kinematic and dynamic properties of the musculoskeletal system are controlled to achieve such efficiency. Even though recent studies have shown that the human motor control relies on multiple models, how the central nervous system (CNS) controls this combination is not fully addressed. In this study, we utilize an Inverse Optimal Control (IOC) framework in order to find the combination of those internal models and how this combination changes for different reaching tasks. We conducted an experiment where participants executed a comprehensive set of free-space reaching motions. The results show that there is a trade-off between kinematics and dynamics based controllers depending on the reaching task. In addition, this trade-off depends on the initial and final arm configurations, which in turn affect the musculoskeletal load to be controlled. Given this insight, we further provide a discomfort metric to demonstrate its influence on the contribution of different inverse internal models. This formulation together with our analysis not only support the multiple internal models (MIMs) hypothesis but also suggest a hierarchical framework for the control of human reaching motions by the CNS.

  10. The reach and adoption of a coach-led exercise training programme in community football.

    Science.gov (United States)

    Finch, Caroline F; Diamantopoulou, Kathy; Twomey, Dara M; Doyle, Tim L A; Lloyd, David G; Young, Warren; Elliott, Bruce C

    2014-04-01

    To determine the reach and adoption of a coach-led exercise training programme for lower limb injury prevention. Secondary analysis of data from a group-clustered randomised controlled trial. A periodised exercise training warm-up programme was delivered to players during training sessions over an 8-week preseason (weeks 1-8) and 18-week playing season. 1564 community Australian football players. Reach, measured weekly, was the number of players who attended training sessions. Adoption was the number of attending players who completed the programme in full, partially or not at all. Reasons for partial or non-participation were recorded. In week 1, 599 players entered the programme; 55% attended 1 training session and 45% attended > 1 session. By week 12, 1540 players were recruited but training attendance (reach) decreased to <50%. When players attended training, the majority adopted the full programme-ranging from 96% (week 1) to above 80% until week 20. The most common reasons for low adoption were players being injured, too sore, being late for training or choosing their own warm-up. The training programme's reach was highest preseason and halved at the playing season's end. However, when players attended training sessions, their adoption was high and remained close to 70% by season end. For sports injury prevention programmes to be fully effective across a season, attention also needs to be given to (1) encouraging players to attend formal training sessions and (2) considering the possibility of some form of programme delivery outside of formal training.

  11. Optimization of stand-alone photovoltaic systems with hydrogen storage for total energy self-sufficiency

    Energy Technology Data Exchange (ETDEWEB)

    Lund, P D [Helsinki Univ. of Technology, Espoo (Finland). Dept. of Technical Physics

    1991-01-01

    A new method for optimization of stand-alone photovoltaic-hydrogen energy systems is presented. The methodology gives the optimum values for the solar array and hydrogen storage size for any given system configuration and geographical site. Sensitivity analyses have been performed to study the effect of subsystem efficiencies on the total system performance and sizing, and also to identify possibilities for further improvements. Optimum system configurations have also been derived. The results indicate that a solar-hydrogen energy system is a very promising potential alternative for low power applications requiring a total electricity self-sufficiency. (Author).

  12. Sufficient condition for confinement of static quarks by a vortex condensation mechanism

    International Nuclear Information System (INIS)

    Mack, G.; Petkova, V.B.

    1978-11-01

    We derive a sufficient condition for confinement of static quarks by a vortex condensation mechanism. It admits vortices that are thick at all times at the cost of constraining them to a finite volume Λi whose complement is not simply connected. The confining potential V(L) is estimated in terms of the change of free energy of a system enclosed in Λi which is induced by a change in vorticity (= singular gauge transformation applied to boundary conditions on deltaΛi). For Abelian gauge theories in 3 dimensions the confining Coulomb potential is reproduced as a lower bound. (orig.) [de

  13. The autonomous house: a bio-hydrogen based energy self-sufficient approach.

    Science.gov (United States)

    Chen, Shang-Yuan; Chu, Chen-Yeon; Cheng, Ming-Jen; Lin, Chiu-Yue

    2009-04-01

    In the wake of the greenhouse effect and global energy crisis, finding sources of clean, alternative energy and developing everyday life applications have become urgent tasks. This study proposes the development of an "autonomous house" emphasizing the use of modern green energy technology to reduce environmental load, achieve energy autonomy and use energy intelligently in order to create a sustainable, comfortable living environment. The houses' two attributes are: (1) a self-sufficient energy cycle and (2) autonomous energy control to maintain environmental comfort. The autonomous house thus combines energy-conserving, carbon emission-reducing passive design with active elements needed to maintain a comfortable environment.

  14. A necessary and sufficient condition for the convergence of an AOR iterative method

    International Nuclear Information System (INIS)

    Hu Jiagan

    1992-01-01

    In this paper, a necessary and sufficient condition for the convergence of an AOR iterative method is given under the condition that the coefficient matrix A is consistently ordered and the eigenvalues of the Jacobi matrix of A are all real. With the same method the condition for the convergence of t he extrapolation Gauss-Seidel (EGS) method is also obtained. As an example, the conditions for the model problem are given. The rate of convergence of the EGS method is about twice that of the GS method

  15. Increased conjugated bilirubin is sufficient to initiate screening for biliary atresia

    DEFF Research Database (Denmark)

    Madsen, Stine Skipper; Kvist, Nina; Thorup, Jørgen

    2015-01-01

    . This percentage value has caused diagnostic trouble over the years. The objective of the present study was to investigate the possibility of changing the recommendations. METHODS: This was a retrospective analysis of the medical records of children operated for biliary atresia in the 1993-2012 period. RESULTS......: mean 129.7 μmol/l (42-334 μmol/l) and 73% (28-97%), respectively. CONCLUSION: The total amount of conjugated bilirubin above 20 μmol/l is sufficient to require further evaluation for biliary atresia. The percentage value is unnecessary and may cause confusion. FUNDING: none. TRIAL REGISTRATION...

  16. Necessary and Sufficient Process leading to Work Smart Standards. Final report

    International Nuclear Information System (INIS)

    1996-11-01

    The Necessary and Sufficient Process leading to Work Smart Standards is a Department of Energy initiative to assure adequate protection for workers, the public, and the environment. The Work Smart Standards initiative directs the Laboratory to develop a set of ES and H standards based on the work performed at the Laboratory and the hazards associated with the work. Berkeley Lab's set of Work Smart Standards includes required Federal, State and local laws and, additionally, national and international standards which represent the highest operating standards of industrial and commercial institutions

  17. Necessary and Sufficient Process leading to Work Smart Standards. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The Necessary and Sufficient Process leading to Work Smart Standards is a Department of Energy initiative to assure adequate protection for workers, the public, and the environment. The Work Smart Standards initiative directs the Laboratory to develop a set of ES and H standards based on the work performed at the Laboratory and the hazards associated with the work. Berkeley Lab`s set of Work Smart Standards includes required Federal, State and local laws and, additionally, national and international standards which represent the highest operating standards of industrial and commercial institutions.

  18. On the necessity and sufficiency of local commutativity for causality in quantum mechanics

    International Nuclear Information System (INIS)

    Muynck, W.M. de.

    1984-01-01

    This thesis contributes to the resolution of the question whether quantum mechanics admits an objectivistic interpretation if the description is restricted to the phenomenalistic domain of the quantum mechanical observables. Without touching the realism-phenomenalism dichotomy, this thesis investigates the possibility to disregard the influence of the measurement interaction on the qm measuring results. In the first part, the measuring process is studied and its influence on the objectivity of measuring results. The measurement of a local observable is interpreted as a local operation. Its local commutativity is a necessary condition for macrocausality. In the second part the converse question is studied, viz. Whether local commutativity is sufficient for macrocausality. (Auth.)

  19. INDONESIAN FOOD POLICY: THE PROGRAMS FOR STRENGTHENING FOOD SELF-SUFFICIENCY IN REFORMATION ERA

    Directory of Open Access Journals (Sweden)

    Kamrussamad

    2018-04-01

    Full Text Available The 2012 decree #18, the policy on food states that objective of food implementation is to meet basic human needs and provide fair, equitable, and sustainable benefits based on food sovereignty, food self-sufficiency, and national food security. Food sovereignty, independence and security are fundamental and supports implementation of policies related to food implementation in Indonesia. The 2012 decree #18 stated that food implementation aims to improve ability to produce food independently, provide a variety of food and meet the requirements of security, quality, and nutrition for public consumption.

  20. Monte Carlo based demonstration of sufficiently dimensioned shielding for a Co-60 testing facility

    International Nuclear Information System (INIS)

    Wind, Michael; Beck, Peter; Latocha, Marcin

    2015-01-01

    The electrical properties of electronic equipment can be changed in an ionized radiation field. The knowledge of these changes is necessary for applications in space, in air traffic and nuclear medicine. Experimental tests will be performed in Co-60 radiation fields in the irradiation facility (TEC facility) of the Seibersdorf Labor GmbH that is in construction. The contribution deals with a simulation that is aimed to calculate the local dose rate within and outside the building for demonstration of sufficient dimensioning of the shielding in compliance with the legal dose rate limits.

  1. The Autonomous House: A Bio-Hydrogen Based Energy Self-Sufficient Approach

    Science.gov (United States)

    Chen, Shang-Yuan; Chu, Chen-Yeon; Cheng, Ming-jen; Lin, Chiu-Yue

    2009-01-01

    In the wake of the greenhouse effect and global energy crisis, finding sources of clean, alternative energy and developing everyday life applications have become urgent tasks. This study proposes the development of an “autonomous house” emphasizing the use of modern green energy technology to reduce environmental load, achieve energy autonomy and use energy intelligently in order to create a sustainable, comfortable living environment. The houses’ two attributes are: (1) a self-sufficient energy cycle and (2) autonomous energy control to maintain environmental comfort. The autonomous house thus combines energy-conserving, carbon emission-reducing passive design with active elements needed to maintain a comfortable environment. PMID:19440531

  2. Forty Necessary and Sufficient Conditions for Regularity of Interval Matrices: A survey

    Czech Academy of Sciences Publication Activity Database

    Rohn, Jiří

    2009-01-01

    Roč. 18, - (2009), s. 500-512 E-ISSN 1081-3810 R&D Projects: GA ČR GA201/09/1957; GA ČR GC201/08/J020 Institutional research plan: CEZ:AV0Z10300504 Keywords : interval matrix * regularity * singularity * necessary and sufficient condition * algorithm Subject RIV: BA - General Mathematics Impact factor: 0.892, year: 2009 http://www.math.technion.ac.il/iic/ ela / ela -articles/articles/vol18_pp500-512.pdf

  3. From reaching every district to reaching every community: analysis and response to the challenge of equity in immunization in Cambodia

    Science.gov (United States)

    Chan Soeung, Sann; Grundy, John; Duncan, Richard; Thor, Rasoka; Bilous, Julian B

    2013-01-01

    Background An international review of the Cambodian Expanded Programme on Immunization (EPI) in 2010 and other data show that despite immunization coverage increases and vaccine preventable diseases incidence reductions, inequities in access to immunization services exist. Utilizing immunization and health systems literature, analysis of global health databases and the EPI review findings, this paper examines the characteristics of immunization access and outcome inequities, and describes proposed longer-term strategic and operational responses to these problems. Findings The national programme has evolved from earlier central and provincial level planning to strengthening routine immunization coverage through the District level ‘Reaching Every District Strategy’. However, despite remarkable improvements, the review found over 20% of children surveyed were not fully immunized, primarily from communities where inequities of both access and impact persist. These inequities relate mainly to socio-economic exposures including wealth and education level, population mobility and ethnicity. To address these problems, a shift in strategic and operational response is proposed that will include (a) a re-focus of planning on facility level to detect disadvantaged communities, (b) establishment of monitoring systems to provide detailed information on community access and utilization, (c) development of communication strategies and health networks that enable providers to adjust service delivery according to the needs of vulnerable populations, and (d) securing financial, management and political commitment for ‘reaching every community’. Conclusions For Cambodia to achieve its immunization equity objectives and disease reduction goals, a shift of emphasis to health centre and community is needed. This approach will maximize the benefits of new vaccine introduction in the coming ‘Decade of Vaccines’, plus potentially extend the reach of other life-saving maternal

  4. Integrating lateral contributions along river reaches to improve SWOT discharge estimates

    Science.gov (United States)

    Beighley, E.; Zhao, Y.; Feng, D.; Fisher, C. K.; Raoufi, R.; Durand, M. T.; David, C. H.; Lee, H.; Boone, A. A.; Cretaux, J. F.

    2016-12-01

    Understanding the potential impacts of climate and land cover change at continental to global scales with a sufficient resolution for community scale planning and management requires an improved representation of the hydrologic cycle that is possible based on existing measurement networks and current Earth system models. The Surface Water and Ocean Topography (SWOT) mission, scheduled to launch in 2021, has the potential to address this challenge by providing measurements of water surface elevation, slope and extent for rivers wider than roughly 50-100 meters at a temporal sampling frequency ranging from days to weeks. The global uniformity and space/time resolution of the proposed SWOT measurements will enable hydrologic discovery, model advancements and new applications addressing the above challenges that are not currently possible or likely even conceivable. One derived data product planned for the SWOT mission is river discharge. Although there are several discharge algorithms that perform well for a range of conditions, this effort is focused on the MetroMan discharge algorithm. For example, in MetroMan, lateral inflow assumptions have been shown to impact performance. Here, the role of lateral inflows on discharge estimate performance is investigated. Preliminary results are presented for the Ohio River Basin. Lateral inflows are quantified for SWOT-observable river reaches using surface and subsurface runoff from North American Land Data Assimilation System (NLDAS) and lateral routing in the Hillslope River Routing (HRR) model. Frequency distributions for the fraction of reach-averaged discharge resulting from lateral inflow are presented. Future efforts will integrate lateral inflow characteristics into the MetroMan discharge algorithm and quantify the potential value of SWOT measurement in flood insurance applications.

  5. TGF-β Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation

    Directory of Open Access Journals (Sweden)

    Maryline Abrial

    2017-07-01

    Full Text Available The pharyngeal arch arteries (PAAs are transient embryonic blood vessels that mature into critical segments of the aortic arch and its branches. Although defects in PAA development cause life-threating congenital cardiovascular defects, the molecular mechanisms that orchestrate PAA morphogenesis remain unclear. Through small-molecule screening in zebrafish, we identified TGF-β signaling as indispensable for PAA development. Specifically, chemical inhibition of the TGF-β type I receptor ALK5 impairs PAA development because nkx2.5+ PAA progenitor cells fail to differentiate into tie1+ angioblasts. Consistent with this observation, we documented a burst of ALK5-mediated Smad3 phosphorylation within PAA progenitors that foreshadows angioblast emergence. Remarkably, premature induction of TGF-β receptor activity stimulates precocious angioblast differentiation, thereby demonstrating the sufficiency of this pathway for initiating the PAA progenitor to angioblast transition. More broadly, these data uncover TGF-β as a rare signaling pathway that is necessary and sufficient for angioblast lineage commitment.

  6. Design of fuel cell powered data centers for sufficient reliability and availability

    Science.gov (United States)

    Ritchie, Alexa J.; Brouwer, Jacob

    2018-04-01

    It is challenging to design a sufficiently reliable fuel cell electrical system for use in data centers, which require 99.9999% uptime. Such a system could lower emissions and increase data center efficiency, but the reliability and availability of such a system must be analyzed and understood. Currently, extensive backup equipment is used to ensure electricity availability. The proposed design alternative uses multiple fuel cell systems each supporting a small number of servers to eliminate backup power equipment provided the fuel cell design has sufficient reliability and availability. Potential system designs are explored for the entire data center and for individual fuel cells. Reliability block diagram analysis of the fuel cell systems was accomplished to understand the reliability of the systems without repair or redundant technologies. From this analysis, it was apparent that redundant components would be necessary. A program was written in MATLAB to show that the desired system reliability could be achieved by a combination of parallel components, regardless of the number of additional components needed. Having shown that the desired reliability was achievable through some combination of components, a dynamic programming analysis was undertaken to assess the ideal allocation of parallel components.

  7. A blueprint for complete energy self-sufficiency in British Columbia

    International Nuclear Information System (INIS)

    2007-01-01

    The Endless Energy Project is a partnership between the Globe Foundation, BC Hydro, Day 4 Energy, the Power Technology Alliance, the National Research Council of Canada, and Western Economic Diversification. The purpose of the project is to examine British Columbia's potential to be energy self-sufficient from renewable sources by 2025. Background information on the Endless Energy Project was presented with reference to energy use in all sectors of the economy and energy supply from all sources indigenous to the province. The report discussed global drivers and scenarios as well as energy use trends specific to British Columbia. These trends were related to energy use for residential buildings; commercial sector; domestic transportation; gateway transportation; and industrial sources. The report also provided an outlook for each of these sectors. A large-scale supply outlook was also described for solar; geothermal; wind; hydro; biomass; forest waste to energy potential; ocean wave energy potential; and tidal current systems. The report concluded with a discussion of matching renewable energy supplies to demand. It was concluded that based on a combination of renewable energy supply, cleaner burning fuels, such as hydrogen and ethanol, and energy use reduction in homes, businesses, and public sector operations, British Columbia could reasonably achieve energy self-sufficiency by 2025. tabs., figs

  8. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain?

    Science.gov (United States)

    Domenichiello, Anthony F; Kitson, Alex P; Bazinet, Richard P

    2015-07-01

    Docosahexaenoic acid (DHA) is important for brain function, and can be obtained directly from the diet or synthesized in the body from α-linolenic acid (ALA). Debate exists as to whether DHA synthesized from ALA can provide sufficient DHA for the adult brain, as measures of DHA synthesis from ingested ALA are typically <1% of the oral ALA dose. However, the primary fate of orally administered ALA is β-oxidation and long-term storage in adipose tissue, suggesting that DHA synthesis measures involving oral ALA tracer ingestion may underestimate total DHA synthesis. There is also evidence that DHA synthesized from ALA can meet brain DHA requirements, as animals fed ALA-only diets have brain DHA concentrations similar to DHA-fed animals, and the brain DHA requirement is estimated to be only 2.4-3.8 mg/day in humans. This review summarizes evidence that DHA synthesis from ALA can provide sufficient DHA for the adult brain by examining work in humans and animals involving estimates of DHA synthesis and brain DHA requirements. Also, an update on methods to measure DHA synthesis in humans is presented highlighting a novel approach involving steady-state infusion of stable isotope-labeled ALA that bypasses several limitations of oral tracer ingestion. It is shown that this method produces estimates of DHA synthesis that are at least 3-fold higher than brain uptake rates in rats. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  9. AN ALTERNATIVE APPROACH TO MEET BEEF SELF-SUFFICIENCY IN WEST PAPUA

    Directory of Open Access Journals (Sweden)

    S. Hartono

    2011-09-01

    Full Text Available The main objective of this research is to present an alternative approach to meet beef self-sufficiency in West Papua, Indonesia. It mainly focuses on calculating the needed number of productive cows to enhance beef production in the province. Out of the total farmer households in Manokwari, Indonesia, 189 farmer-respondents were selected as samples of the study. Selection of the sample was based on the number of cattle kept in every age group (less than one (2 years old and the number of productive cows. Secondary data came from the time series data of the number of slaughtered cattle vis-à-vis the population of all districts in West Papua Province from 1980-2008. Data were analyzed using the Partial Adjustment Model (PAM and Ordinary Least Square (OLS method. Results of the study showed that beef self-sufficiency in West Papua depend on the availability of the number of productive cows to produce ready-slaughtered-bull in the previous year. Particularly for West Papua, to produce one unit of bull in the tth –year, with the assumption that cattle mortality is 4.92%, a number of 2.38 animal units AU of productive cows must be provided in the previous two (2 years.

  10. Scheduling of Crude Oil Operations in Refinery without Sufficient Charging Tanks Using Petri Nets

    Directory of Open Access Journals (Sweden)

    Yan An

    2017-05-01

    Full Text Available A short-term schedule for crude oil operations in a refinery should define and sequence the activities in detail. Each activity involves both discrete-event and continuous variables. The combinatorial nature of the scheduling problem makes it difficult to solve. For such a scheduling problem, charging tanks are a type of critical resources. If the number of charging tanks is not sufficient, the scheduling problem is further complicated. This work conducts a study on the scheduling problem of crude oil operations without sufficient charging tanks. In this case, to make a refinery able to operate, a charging tank has to be in simultaneous charging and feeding to a distiller for some time, called simultaneously-charging-and-feeding (SCF mode, leading to disturbance to the oil distillation in distillers. A hybrid Petri net model is developed to describe the behavior of the system. Then, a scheduling method is proposed to find a schedule such that the SCF mode is minimally used. It is computationally efficient. An industrial case study is given to demonstrate the obtained results.

  11. Necessary and sufficient liveness condition of GS3PR Petri nets

    Science.gov (United States)

    Liu, GaiYun; Barkaoui, Kamel

    2015-05-01

    Structural analysis is one of the most important and efficient methods to investigate the behaviour of Petri nets. Liveness is a significant behavioural property of Petri nets. Siphons, as structural objects of a Petri net, are closely related to its liveness. Many deadlock control policies for flexible manufacturing systems (FMS) modelled by Petri nets are implemented via siphon control. Most of the existing methods design liveness-enforcing supervisors by adding control places for siphons based on their controllability conditions. To compute a liveness-enforcing supervisor with as much as permissive behaviour, it is both theoretically and practically significant to find an exact controllability condition for siphons. However, the existing conditions, max, max‧, and max″-controllability of siphons are all overly restrictive and generally sufficient only. This paper develops a new condition called max*-controllability of the siphons in generalised systems of simple sequential processes with resources (GS3PR), which are a net subclass that can model many real-world automated manufacturing systems. We show that a GS3PR is live if all its strict minimal siphons (SMS) are max*-controlled. Compared with the existing conditions, i.e., max-, max‧-, and max″-controllability of siphons, max*-controllability of the SMS is not only sufficient but also necessary. An example is used to illustrate the proposed method.

  12. Measuring what latent fingerprint examiners consider sufficient information for individualization determinations.

    Directory of Open Access Journals (Sweden)

    Bradford T Ulery

    Full Text Available Latent print examiners use their expertise to determine whether the information present in a comparison of two fingerprints (or palmprints is sufficient to conclude that the prints were from the same source (individualization. When fingerprint evidence is presented in court, it is the examiner's determination--not an objective metric--that is presented. This study was designed to ascertain the factors that explain examiners' determinations of sufficiency for individualization. Volunteer latent print examiners (n = 170 were each assigned 22 pairs of latent and exemplar prints for examination, and annotated features, correspondence of features, and clarity. The 320 image pairs were selected specifically to control clarity and quantity of features. The predominant factor differentiating annotations associated with individualization and inconclusive determinations is the count of corresponding minutiae; other factors such as clarity provided minimal additional discriminative value. Examiners' counts of corresponding minutiae were strongly associated with their own determinations; however, due to substantial variation of both annotations and determinations among examiners, one examiner's annotation and determination on a given comparison is a relatively weak predictor of whether another examiner would individualize. The extensive variability in annotations also means that we must treat any individual examiner's minutia counts as interpretations of the (unknowable information content of the prints: saying "the prints had N corresponding minutiae marked" is not the same as "the prints had N corresponding minutiae." More consistency in annotations, which could be achieved through standardization and training, should lead to process improvements and provide greater transparency in casework.

  13. Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes.

    Science.gov (United States)

    Chapouly, Candice; Yao, Qinyu; Vandierdonck, Soizic; Larrieu-Lahargue, Frederic; Mariani, John N; Gadeau, Alain-Pierre; Renault, Marie-Ange

    2016-02-01

    Microangiopathy, i.e. endothelial dysfunction, has long been suggested to contribute to the development of diabetic neuropathy, although this has never been fully verified. In the present paper, we have identified the role of Hedgehog (Hh) signalling in endoneurial microvessel integrity and evaluated the impact of impaired Hh signalling in endothelial cells (ECs) on nerve function. By using Desert Hedgehog (Dhh)-deficient mice, we have revealed, that in the absence of Dhh, endoneurial capillaries are abnormally dense and permeable. Furthermore, Smoothened (Smo) conditional KO mice clarified that this increased vessel permeability is specifically due to impaired Hh signalling in ECs and is associated with a down-regulation of Claudin5 (Cldn5). Moreover, impairment of Hh signalling in ECs was sufficient to induce hypoalgesia and neuropathic pain. Finally in Lepr(db/db) type 2 diabetic mice, the loss of Dhh expression observed in the nerve was shown to be associated with increased endoneurial capillary permeability and decreased Cldn5 expression. Conversely, systemic administration of the Smo agonist SAG increased Cldn5 expression, decreased endoneurial capillary permeability, and restored thermal algesia to diabetic mice, demonstrating that loss of Dhh expression is crucial in the development of diabetic neuropathy. The present work demonstrates the critical role of Dhh in maintaining blood nerve barrier integrity and demonstrates for the first time that endothelial dysfunction is sufficient to induce neuropathy. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

  14. Energy self-sufficient sewage wastewater treatment plants: is optimized anaerobic sludge digestion the key?

    Science.gov (United States)

    Jenicek, P; Kutil, J; Benes, O; Todt, V; Zabranska, J; Dohanyos, M

    2013-01-01

    The anaerobic digestion of primary and waste activated sludge generates biogas that can be converted into energy to power the operation of a sewage wastewater treatment plant (WWTP). But can the biogas generated by anaerobic sludge digestion ever completely satisfy the electricity requirements of a WWTP with 'standard' energy consumption (i.e. industrial pollution not treated, no external organic substrate added)? With this question in mind, we optimized biogas production at Prague's Central Wastewater Treatment Plant in the following ways: enhanced primary sludge separation; thickened waste activated sludge; implemented a lysate centrifuge; increased operational temperature; improved digester mixing. With these optimizations, biogas production increased significantly to 12.5 m(3) per population equivalent per year. In turn, this led to an equally significant increase in specific energy production from approximately 15 to 23.5 kWh per population equivalent per year. We compared these full-scale results with those obtained from WWTPs that are already energy self-sufficient, but have exceptionally low energy consumption. Both our results and our analysis suggest that, with the correct optimization of anaerobic digestion technology, even WWTPs with 'standard' energy consumption can either attain or come close to attaining energy self-sufficiency.

  15. Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains.

    Science.gov (United States)

    Tataru, Paula; Hobolth, Asger

    2011-12-05

    Continuous time Markov chains (CTMCs) is a widely used model for describing the evolution of DNA sequences on the nucleotide, amino acid or codon level. The sufficient statistics for CTMCs are the time spent in a state and the number of changes between any two states. In applications past evolutionary events (exact times and types of changes) are unaccessible and the past must be inferred from DNA sequence data observed in the present. We describe and implement three algorithms for computing linear combinations of expected values of the sufficient statistics, conditioned on the end-points of the chain, and compare their performance with respect to accuracy and running time. The first algorithm is based on an eigenvalue decomposition of the rate matrix (EVD), the second on uniformization (UNI), and the third on integrals of matrix exponentials (EXPM). The implementation in R of the algorithms is available at http://www.birc.au.dk/~paula/. We use two different models to analyze the accuracy and eight experiments to investigate the speed of the three algorithms. We find that they have similar accuracy and that EXPM is the slowest method. Furthermore we find that UNI is usually faster than EVD.

  16. Comparison of methods for calculating conditional expectations of sufficient statistics for continuous time Markov chains

    Directory of Open Access Journals (Sweden)

    Tataru Paula

    2011-12-01

    Full Text Available Abstract Background Continuous time Markov chains (CTMCs is a widely used model for describing the evolution of DNA sequences on the nucleotide, amino acid or codon level. The sufficient statistics for CTMCs are the time spent in a state and the number of changes between any two states. In applications past evolutionary events (exact times and types of changes are unaccessible and the past must be inferred from DNA sequence data observed in the present. Results We describe and implement three algorithms for computing linear combinations of expected values of the sufficient statistics, conditioned on the end-points of the chain, and compare their performance with respect to accuracy and running time. The first algorithm is based on an eigenvalue decomposition of the rate matrix (EVD, the second on uniformization (UNI, and the third on integrals of matrix exponentials (EXPM. The implementation in R of the algorithms is available at http://www.birc.au.dk/~paula/. Conclusions We use two different models to analyze the accuracy and eight experiments to investigate the speed of the three algorithms. We find that they have similar accuracy and that EXPM is the slowest method. Furthermore we find that UNI is usually faster than EVD.

  17. Hydrodynamic property of the cytoplasm is sufficient to mediate cytoplasmic streaming in the Caenorhabiditis elegans embryo

    Science.gov (United States)

    Niwayama, Ritsuya; Shinohara, Kyosuke; Kimura, Akatsuki

    2011-01-01

    Cytoplasmic streaming is a type of intracellular transport widely seen in nature. Cytoplasmic streaming in Caenorhabditis elegans at the one-cell stage is bidirectional; the flow near the cortex (“cortical flow”) is oriented toward the anterior, whereas the flow in the central region (“cytoplasmic flow”) is oriented toward the posterior. Both cortical flow and cytoplasmic flow depend on non-muscle-myosin II (NMY-2), which primarily localizes in the cortex. The manner in which NMY-2 proteins drive cytoplasmic flow in the opposite direction from remote locations has not been fully understood. In this study, we demonstrated that the hydrodynamic properties of the cytoplasm are sufficient to mediate the forces generated by the cortical myosin to drive bidirectional streaming throughout the cytoplasm. We quantified the flow velocities of cytoplasmic streaming using particle image velocimetry (PIV) and conducted a three-dimensional hydrodynamic simulation using the moving particle semiimplicit method. Our simulation quantitatively reconstructed the quantified flow velocity distribution resolved through PIV analysis. Furthermore, our PIV analyses detected microtubule-dependent flows during the pronuclear migration stage. These flows were reproduced via hydrodynamic interactions between moving pronuclei and the cytoplasm. The agreement of flow dynamics in vivo and in simulation indicates that the hydrodynamic properties of the cytoplasm are sufficient to mediate cytoplasmic streaming in C. elegans embryos. PMID:21730185

  18. Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells

    Science.gov (United States)

    Ortega, Fabian E.; Rengarajan, Michelle; Chavez, Natalie; Radhakrishnan, Prathima; Gloerich, Martijn; Bianchini, Julie; Siemers, Kathleen; Luckett, William S.; Lauer, Peter; Nelson, W. James; Theriot, Julie A.

    2017-01-01

    The intestinal epithelium is the first physiological barrier breached by the Gram-positive facultative pathogen Listeria monocytogenes during an in vivo infection. Listeria monocytogenes binds to the epithelial host cell receptor E-cadherin, which mediates a physical link between the bacterium and filamentous actin (F-actin). However, the importance of anchoring the bacterium to F-actin through E-cadherin for bacterial invasion has not been tested directly in epithelial cells. Here we demonstrate that depleting αE-catenin, which indirectly links E-cadherin to F-actin, did not decrease L. monocytogenes invasion of epithelial cells in tissue culture. Instead, invasion increased due to increased bacterial adhesion to epithelial monolayers with compromised cell–cell junctions. Furthermore, expression of a mutant E-cadherin lacking the intracellular domain was sufficient for efficient L. monocytogenes invasion of epithelial cells. Importantly, direct biotin-mediated binding of bacteria to surface lipids in the plasma membrane of host epithelial cells was sufficient for uptake. Our results indicate that the only requirement for L. monocytogenes invasion of epithelial cells is adhesion to the host cell surface, and that E-cadherin–mediated coupling of the bacterium to F-actin is not required. PMID:28877987

  19. Engineering human cytochrome P450 enzymes into catalytically self-sufficient chimeras using molecular Lego.

    Science.gov (United States)

    Dodhia, Vikash Rajnikant; Fantuzzi, Andrea; Gilardi, Gianfranco

    2006-10-01

    The membrane-bound human cytochrome P450s have essential roles in the metabolism of endogenous compounds and drugs. Presented here are the results on the construction and characterization of three fusion proteins containing the N-terminally modified human cytochrome P450s CYP2C9, CY2C19 and CYP3A4 fused to the soluble NADPH-dependent oxidoreductase domain of CYP102A1 from Bacillus megaterium. The constructs, CYP2C9/BMR, CYP2C19/BMR and CYP3A4/BMR are well expressed in Escherichia coli as holo proteins. The chimeras can be purified in the absence of detergent and the purified enzymes are both active and correctly folded in the absence of detergent, as demonstrated by circular dichroism and functional studies. Additionally, in comparison with the parent P450 enzyme, these chimeras have greatly improved solubility properties. The chimeras are catalytically self-sufficient and present turnover rates similar to those reported for the native enzymes in reconstituted systems, unlike previously reported mammalian cytochrome P450 fusion proteins. Furthermore the specific activities of these chimeras are not dependent on the enzyme concentration present in the reaction buffer and they do not require the addition of accessory proteins, detergents or phospholipids to be fully active. The solubility, catalytic self-sufficiency and wild-type like activities of these chimeras would greatly simplify the studies of cytochrome P450 mediated drug metabolism in solution.

  20. Osteocalcin is necessary and sufficient to maintain muscle mass in older mice

    Directory of Open Access Journals (Sweden)

    Paula Mera

    2016-10-01

    Full Text Available Objective: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether this hormone might regulate muscle mass as mice age. Methods: We examined muscle mass and strength in mice lacking osteocalcin (Ocn−/− or its receptor in all cells (Gprc6a−/− or specifically in myofibers (Gprc6aMck−/− as well as in 9 month-old WT mice receiving exogenous osteocalcin for 28 days. We also examined protein synthesis in WT and Gprc6a−/− mouse myotubes treated with osteocalcin. Results: We show that osteocalcin signaling in myofibers is necessary to maintain muscle mass in older mice in part because it promotes protein synthesis in myotubes without affecting protein breakdown. We further show that treatment with exogenous osteocalcin for 28 days is sufficient to increase muscle mass of 9-month-old WT mice. Conclusion: This study uncovers that osteocalcin is necessary and sufficient to prevent age-related muscle loss in mice. Author Video: Author Video Watch what authors say about their articles Keywords: Osteocalcin, Muscle mass, Aging

  1. Revenue Sufficiency and Reliability in a Zero Marginal Cost Future: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Frew, Bethany A.; Milligan, Michael; Brinkman, Greg; Bloom, Aaron; Clark, Kara; Denholm, Paul

    2016-12-01

    Features of existing wholesale electricity markets, such as administrative pricing rules and policy-based reliability standards, can distort market incentives from allowing generators sufficient opportunities to recover both fixed and variable costs. Moreover, these challenges can be amplified by other factors, including (1) inelastic demand resulting from a lack of price signal clarity, (2) low- or near-zero marginal cost generation, particularly arising from low natural gas fuel prices and variable generation (VG), such as wind and solar, and (3) the variability and uncertainty of this VG. As power systems begin to incorporate higher shares of VG, many questions arise about the suitability of the existing marginal-cost-based price formation, primarily within an energy-only market structure, to ensure the economic viability of resources that might be needed to provide system reliability. This article discusses these questions and provides a summary of completed and ongoing modelling-based work at the National Renewable Energy Laboratory to better understand the impacts of evolving power systems on reliability and revenue sufficiency.

  2. Attended but unseen: visual attention is not sufficient for visual awareness.

    Science.gov (United States)

    Kentridge, R W; Nijboer, T C W; Heywood, C A

    2008-02-12

    Does any one psychological process give rise to visual awareness? One candidate is selective attention-when we attend to something it seems we always see it. But if attention can selectively enhance our response to an unseen stimulus then attention cannot be a sufficient precondition for awareness. Kentridge, Heywood & Weiskrantz [Kentridge, R. W., Heywood, C. A., & Weiskrantz, L. (1999). Attention without awareness in blindsight. Proceedings of the Royal Society of London, Series B, 266, 1805-1811; Kentridge, R. W., Heywood, C. A., & Weiskrantz, L. (2004). Spatial attention speeds discrimination without awareness in blindsight. Neuropsychologia, 42, 831-835.] demonstrated just such a dissociation in the blindsight subject GY. Here, we test whether the dissociation generalizes to the normal population. We presented observers with pairs of coloured discs, each masked by the subsequent presentation of a coloured annulus. The discs acted as primes, speeding discrimination of the colour of the annulus when they matched in colour and slowing it when they differed. We show that the location of attention modulated the size of this priming effect. However, the primes were rendered invisible by metacontrast-masking and remained unseen despite being attended. Visual attention could therefore facilitate processing of an invisible target and cannot, therefore, be a sufficient precondition for visual awareness.

  3. Continuous real-time in vivo measurement of cerebral nitric oxide supports theoretical predictions of an irreversible switching in cerebral ROS after sufficient exposure to external toxins.

    Science.gov (United States)

    Finnerty, Niall J; O'Riordan, Saidhbhe L; Lowry, John P; Cloutier, Mathieu; Wellstead, Peter

    2013-01-01

    Mathematical models of the interactions between alphasynuclein (αS) and reactive oxygen species (ROS) predict a systematic and irreversible switching to damagingly high levels of ROS after sufficient exposure to risk factors associated with Parkinson's disease (PD). We tested this prediction by continuously monitoring real-time changes in neurochemical levels over periods of several days in animals exposed to a toxin known to cause Parkinsonian symptoms. Nitric oxide (NO) sensors were implanted in the brains of freely moving rats and the NO levels continuously recorded while the animals were exposed to paraquat (PQ) injections of various amounts and frequencies. Long-term, real-time measurement of NO in a cohort of animals showed systematic switching in levels when PQ injections of sufficient size and frequency were administered. The experimental observations of changes in NO imply a corresponding switching in endogenous ROS levels and support theoretical predictions of an irreversible change to damagingly high levels of endogenous ROS when PD risks are sufficiently large. Our current results only consider one form of PD risk, however, we are sufficiently confident in them to conclude that: (i) continuous long-term measurement of neurochemical dynamics provide a novel way to measure the temporal change and system dynamics which determine Parkinsonian damage, and (ii) the bistable feedback switching predicted by mathematical modelling seems to exist and that a deeper analysis of its characteristics would provide a way of understanding the pathogenic mechanisms that initiate Parkinsonian cell damage.

  4. Transparency of chemical risk assessment data under REACH.

    Science.gov (United States)

    Ingre-Khans, Ellen; Ågerstrand, Marlene; Beronius, Anna; Rudén, Christina

    2016-12-08

    The REACH regulation requires EU manufacturers and importers of substances to register information on the hazard and risk of their substances with the European Chemicals Agency (ECHA). Risk management of the substances is based on the provided information. It is known that conclusions on hazard and risk are influenced by expert judgements as well as potential conflict of interests. Thus, it is important that hazard and risk assessments are transparent and can be evaluated by a third party. The aim of this study is to scrutinize the transparency, i.e. the accessibility and comprehensibility, of information on substances registered under REACH. Data on repeated dose toxicity and hazard assessment conclusions were extracted for 60 substances from the REACH registration database available on the ECHA website. The data were compiled in a database for systematically evaluating the transparency of information related to the conclusions on hazard or risk. In addition, chemical safety reports (CSR) were requested from ECHA for five substances. The transparency of information on the hazard and risk of substances was found to be limited for several reasons. First, certain information was removed due to confidentiality and certain fields were not published because they could contain confidential information although the information had not been claimed confidential. Also, the extent to which registrants reported information varied, and the presentation of some data and certain terminology required further clarification. In addition, the data source for the majority of the key and supporting studies could not be identified due to confidentiality. Since registrants are only required to summarise studies, it cannot be verified whether all relevant information from non-public industry reports have been reported. Lastly, certain information related to the hazard and risk assessment were only reported in the CSR which is only available upon request; a time-consuming and work

  5. Is Transducer Hygiene sufficient when Vaginal Probes are used in the Clinical Routine?

    Science.gov (United States)

    Merz, E

    2016-04-01

    special virucidal wipes on the probes is considered low-level disinfection. Primarily quaternary ammonia compounds are employed for this procedure. This method is easily applicable, has good cleaning characteristics, is effective against HPV and has high skin tolerance. However, it has the disadvantage of not removing all microorganisms during the disinfection process. Immersion procedures are high-level disinfection methods during which the transducer head is dipped in a special fluid for a certain amount of time. The disinfectants used for this include e. g. preparations based on glutaraldehyde or succinic aldehyde. However, in practice immersion disinfection has a number of disadvantages 13: 1. The procedure cannot be validated. 2. The probe permanently attached to the device must be placed in a separate holder and disinfected for at least 15 minutes. This is impracticable in routine operations in a clinic, outpatient facility or practice with a high number of examinations. 3. After this disinfection method, the probe has to be thoroughly rinsed with potable or higher-quality water in order to remove remnants of allergenic or locally toxic substances. 4. Frequently examinations take place in small interior areas with poor ventilation, thus under some circumstances posing an inhalant-related health hazard. 5. The required virucidal effect is frequently not achieved within 15 minutes 13. Furthermore, extended probe contact with liquid disinfecting agents in the long run results in increased wear of the transducer head membrane.Therefore it was interesting to note that in 2009 a fully-automatic disinfection system for ultrasound probes was introduced to the market (Trophon(EPR). This product, developed in Australia, promised relatively rapid high-level disinfection (HLD). During this software-controlled, mechanical disinfection procedure, the entire ultrasound probe (transducer head and handle) is placed in a sealed disinfection chamber, then hydrogen peroxide (H2O2) is

  6. Rapid Automatic Motor Encoding of Competing Reach Options

    Directory of Open Access Journals (Sweden)

    Jason P. Gallivan

    2017-02-01

    Full Text Available Mounting neural evidence suggests that, in situations in which there are multiple potential targets for action, the brain prepares, in parallel, competing movements associated with these targets, prior to implementing one of them. Central to this interpretation is the idea that competing viewed targets, prior to selection, are rapidly and automatically transformed into corresponding motor representations. Here, by applying target-specific, gradual visuomotor rotations and dissociating, unbeknownst to participants, the visual direction of potential targets from the direction of the movements required to reach the same targets, we provide direct evidence for this provocative idea. Our results offer strong empirical support for theories suggesting that competing action options are automatically represented in terms of the movements required to attain them. The rapid motor encoding of potential targets may support the fast optimization of motor costs under conditions of target uncertainty and allow the motor system to inform decisions about target selection.

  7. The long reach of Alzheimer's disease: patients, practice, and policy.

    Science.gov (United States)

    Bynum, Julie P W

    2014-04-01

    The impact of Alzheimer's disease and related dementias reaches well beyond the health care needs of the person with dementia. As dementia inexorably progresses, the patient becomes increasingly dependent on others for basic daily care and routine tasks, a physically safe environment, and protection from exploitation or abuse. Addressing the diverse medical and social care needs of the burgeoning US population with Alzheimer's disease and related dementias requires the adoption of a broad-based policy framework and agenda that explicitly acknowledge the complex and unique needs of people with dementia and the impacts of dementia on caregivers and society at large. Public policies related to social service providers, agencies that provide appropriate housing, financial and legal services, and law enforcement must complement other policies focused on prevention and risk reduction, effective treatment development, and efficient health care delivery.

  8. The contributions of vision and haptics to reaching and grasping

    Directory of Open Access Journals (Sweden)

    Kayla Dawn Stone

    2015-09-01

    Full Text Available This review aims to provide a comprehensive outlook on the sensory (visual and haptic contributions to reaching and grasping. The focus is on studies in developing children, normal and neuropsychological populations, and in sensory-deprived individuals. Studies have suggested a right-hand/left-hemisphere specialization for visually-guided grasping and a left-hand/right-hemisphere specialization for haptically-guided object recognition. This poses the interesting possibility that when vision is not available and grasping relies heavily on the haptic system, there is an advantage to use the left hand. We review the evidence for this possibility and dissect the unique contributions of the visual and haptic systems to grasping. We ultimately discuss how the integration of these two sensory modalities shape hand preference.

  9. Undoing Racism Through Genesee County's REACH Infant Mortality Reduction Initiative.

    Science.gov (United States)

    Kruger, Daniel J; Carty, Denise C; Turbeville, Ashley R; French-Turner, Tonya M; Brownlee, Shannon

    2015-01-01

    Genesee County Racial and Ethnic Approaches to Community Health Program (REACH) is a Community-Based Public Health partnership for reducing African American infant mortality rates that hosts the Undoing Racism Workshop (URW). Assess the URW's effectiveness in promoting an understanding of racism, institutional racism, and how issues related to race/ethnicity can affect maternal and infant health. Recent URW participants (n=84) completed brief preassessment and postassessment forms; participants (n=101) also completed an on-line, long-term assessment (LTA). URWs promoted understanding of racism and institutional racism, although they were less effective in addressing racism as related to maternal and infant health. The URWs were most effective in the domains related to their standard content. Additional effort is necessary to customize URWs when utilized for activities beyond their original purpose of community mobilization.

  10. Visuo-proprioceptive interactions during adaptation of the human reach.

    Science.gov (United States)

    Judkins, Timothy; Scheidt, Robert A

    2014-02-01

    We examined whether visual and proprioceptive estimates of transient (midreach) target capture errors contribute to motor adaptation according to the probabilistic rules of information integration used for perception. Healthy adult humans grasped and moved a robotic handle between targets in the horizontal plane while the robot generated springlike loads that varied unpredictably from trial to trial. For some trials, a visual cursor faithfully tracked hand motion. In others, the handle's position was locked and subjects viewed motion of a point-mass cursor driven by hand forces. In yet other trials, cursor feedback was dissociated from hand motion or altogether eliminated. We used time- and frequency-domain analyses to characterize how sensorimotor memories influence performance on subsequent reaches. When the senses were used separately, subjects were better at rejecting physical disturbances applied to the hand than virtual disturbances applied to the cursor. In part, this observation reflected differences in how participants used sensorimotor memories to adapt to perturbations when performance feedback was limited to only proprioceptive or visual information channels. When both vision and proprioception were available to guide movement, subjects processed memories in a manner indistinguishable from the vision-only condition, regardless of whether the cursor tracked the hand faithfully or whether we experimentally dissociated motions of the hand and cursor. This was true even though, on average, perceptual uncertainty in the proprioceptive estimation of movement extent exceeded that of visual estimation by just 47%. In contrast to perceptual tasks wherein vision and proprioception both contribute to an optimal estimate of limb state, our findings support a switched-input, multisensory model of predictive load compensation wherein visual feedback of transient performance errors overwhelmingly dominates proprioception in determining adaptive reach performance.

  11. Impact of measles supplementary immunization activities on reaching children missed by routine programs.

    Science.gov (United States)

    Portnoy, Allison; Jit, Mark; Helleringer, Stéphane; Verguet, Stéphane

    2018-01-02

    Measles supplementary immunization activities (SIAs) are vaccination campaigns that supplement routine vaccination programs with a recommended second dose opportunity to children of different ages regardless of their previous history of measles vaccination. They are conducted every 2-4 years and over a few weeks in many low- and middle-income countries. While SIAs have high vaccination coverage, it is unclear whether they reach the children who miss their routine measles vaccine dose. Determining who is reached by SIAs is vital to understanding their effectiveness, as well as measure progress towards measles control. We examined SIAs in low- and middle-income countries from 2000 to 2014 using data from the Demographic and Health Surveys. Conditional on a child's routine measles vaccination status, we examined whether children participated in the most recent measles SIA. The average proportion of zero-dose children (no previous routine measles vaccination defined as no vaccination date before the SIA) reached by SIAs across 14 countries was 66%, ranging from 28% in São Tomé and Príncipe to 91% in Nigeria. However, when also including all children with routine measles vaccination data, this proportion decreased to 12% and to 58% when imputing data for children with vaccination reported by the mother and vaccination marks on the vaccination card across countries. Overall, the proportions of zero-dose children reached by SIAs declined with increasing household wealth. Some countries appeared to reach a higher proportion of zero-dose children using SIAs than others, with proportions reached varying according to the definition of measles vaccination (e.g., vaccination dates on the vaccination card, vaccination marks on the vaccination card, and/or self-reported data). This suggests that some countries could improve their targeting of SIAs to children who miss other measles vaccine opportunities. Across all countries, SIAs played an important role in reaching

  12. Stereotypical reaching movements of the octopus involve both bend propagation and arm elongation.

    Science.gov (United States)

    Hanassy, S; Botvinnik, A; Flash, T; Hochner, B

    2015-05-13

    The bend propagation involved in the stereotypical reaching movement of the octopus arm has been extensively studied. While these studies have analyzed the kinematics of bend propagation along the arm during its extension, possible length changes have been ignored. Here, the elongation profiles of the reaching movements of Octopus vulgaris were assessed using three-dimensional reconstructions. The analysis revealed that, in addition to bend propagation, arm extension movements involve elongation of the proximal part of the arm, i.e., the section from the base of the arm to the propagating bend. The elongations are quite substantial and highly variable, ranging from an average strain along the arm of -0.12 (i.e. shortening) up to 1.8 at the end of the movement (0.57 ± 0.41, n = 64 movements, four animals). Less variability was discovered in an additional set of experiments on reaching movements (0.64 ± 0.28, n = 30 movements, two animals), where target and octopus positions were kept more stationary. Visual observation and subsequent kinematic analysis suggest that the reaching movements can be broadly segregated into two groups. The first group involves bend propagation beginning at the base of the arm and propagating towards the arm tip. In the second, the bend is formed or present more distally and reaching is achieved mainly by elongation and straightening of the segment proximal to the bend. Only in the second type of movements is elongation significantly positively correlated with the distance of the bend from the target. We suggest that reaching towards a target is generated by a combination of both propagation of a bend along the arm and arm elongation. These two motor primitives may be combined to create a broad spectrum of reaching movements. The dynamical model, which recapitulates the biomechanics of the octopus muscular hydrostatic arm, suggests that achieving the observed elongation requires an extremely low ratio of longitudinal to transverse muscle

  13. Can a consensus be reached about nuclear power?

    International Nuclear Information System (INIS)

    Kroeger, W.; ETH, Zurich

    1993-01-01

    Technology itself can create only conditions necessary, but not sufficient, to stabilize or improve the acceptance of a technology perceived negatively. There is consensus, by and large, about the demand for an exclusion of catastrophic accident consequences being the most promising way of addressing this issue. There is dissent, however, about the interpretation and operative execution of this concept. Success will depend very much on a convincing formula for the limitations to such a principle to be developed out of an insight into the unattainability of absolute safety. This can probably be achieved on the basis of sound technical work, but must be integrated into a societal process for which no blueprint exists, and whose result is bound to be ambiguous. A postulated failure exclusion could be used as a point of departure and, in addition, could be turned into sound technology. When applied to nuclear technology, this approach could serve as a model for other technologies whose acceptable safety cannot be described solely in terms of a 'product formula'. This will take a major novel and time-consuming effort, and it will stand a chance to succeed only if the benefits to be reaped are convincing and if the safety and soundness of the technology as perceived daily does not contradict the stringent claims postulated. (orig.) [de

  14. Requirements on qualification, competence and sufficient number of personnel for NPP operation

    International Nuclear Information System (INIS)

    Simon, M.

    2004-01-01

    The safe operation of NPPs presupposes qualified personnel on site in sufficient numbers. While the acquisition and preservation of technical expertise and the qualification of the shift personnel and other staff is well regulated by regulatory guidelines in Germany, there is a lack of such regulations with the exception for shift personnel - for the minimum number of technical personnel required for safe operation of a NPP. By order of the BMU, an attempt was made with this study to work out the requirements for qualification, competence and number of personnel to be maintained at the plant, representing the minimum requirements for safe operation of a NPP. The scope of the project was restricted to requirements for technical plant personnel. The aim was to work out requirements which would be as independent as possible of the existing organisation in a particular power plant. This study therefore does not assume a given organisational structure but was rather more oriented on the work processes in a NPP which are the basis for planning and performing routine work in the plant. For the study a work process model of typical tasks in a NPP had to be developed. Then, the tasks to be performed within the so defined work processes were described (task profiles) on the basis of existing manuals for plant organisation. From these task profiles such tasks were defined or selected which shall not be delegated to external personnel for specific reasons, and which were called vital competences. To keep these vital competences at the plant, an assessment and/or calculation of the necessary number of plant technical personnel was made using the task profiles for responsible personnel, but also by the evaluation of thousands of work orders for maintenance personnel. On the basis of these data, a proposal was made for the minimal number of technical personnel which is necessary to operate a NPP unit safely. Beside of this number, general criteria were developed which should be

  15. Food Self-Sufficiency across scales: How local can we go?

    Science.gov (United States)

    Pradhan, Prajal; Lüdeke, Matthias K. B.; Reusser, Dominik E.; Kropp, Jürgen P.

    2013-04-01

    "Think global, act local" is a phrase often used in sustainability debates. Here, we explore the potential of regions to go for local supply in context of sustainable food consumption considering both the present state and the plausible future scenarios. We analyze data on the gridded crop calories production, the gridded livestock calories production, the gridded feed calories use and the gridded food calories consumption in 5' resolution. We derived these gridded data from various sources: Global Agro-ecological Zone (GAEZ v3.0), Gridded Livestock of the World (GLW), FAOSTAT, and Global Rural-Urban Mapping Project (GRUMP). For scenarios analysis, we considered changes in population, dietary patterns and possibility of obtaining the maximum potential yield. We investigate the food self-sufficiency multiple spatial scales. We start from the 5' resolution (i.e. around 10 km x 10 km in the equator) and look at 8 levels of aggregation ranging from the plausible lowest administrative level to the continental level. Results for the different spatial scales show that about 1.9 billion people live in the area of 5' resolution where enough calories can be produced to sustain their food consumption and the feed used. On the country level, about 4.4 billion population can be sustained without international food trade. For about 1 billion population from Asia and Africa, there is a need for cross-continental food trade. However, if we were able to achieve the maximum potential crop yield, about 2.6 billion population can be sustained within their living area of 5' resolution. Furthermore, Africa and Asia could be food self-sufficient by achieving their maximum potential crop yield and only round 630 million populations would be dependent on the international food trade. However, the food self-sufficiency status might differ under consideration of the future change in population, dietary patterns and climatic conditions. We provide an initial approach for investigating the

  16. [The concept of nutritional self-sufficiency and the demographic equilibrium of Rwanda].

    Science.gov (United States)

    Habimana Nyirasafari, G

    1987-12-01

    Achieving food self-sufficiency is the basic strategy of Rwanda's 4th 5-year plan covering 1987-91. The population growth rate has increased from 3% in 1970 to 3.7% in 1983, with the population doubling between 1964 and 1985. Food production grew by about 4%/year between 1966-83, creating a slight increase in per capita food availability, but the 2171 calories available per capita is dangerously close to the theoretical minimum requirement of 2100 per day. The theoretical protein requirement is almost covered, but there is a serious shortage of oils. The increase in production since 1966 has been due almost exclusively to the extension of cultivated land. But the land supply is limited, and future production increases will need to be based on increased yields per unit cultivated. The National Office of Population has developed a simulation model that analyzes the parallel evolution of population and production so as to identify demographic and development policies that will assure food self-sufficiency and an improvement in living conditions. The population subsystem subjects the population divided by age and sex to the effects of fertility, migration, and mortality. Births are the result of 36 different fertility rates applied to the population of women aged 14-49 years. The agricultural subsystem is tied to the population subsystem by comparison of the volume of population to that of production, by estimation of the proportion of the population living exclusively by subsistence agriculture, by calculation of the potential emigration resulting from overpopulation of the countryside, and by estimation of the links between nutritional level, mortality, and duration of breastfeeding. 5 annexes contain subsystems showing effects of demographic growth on education, employment, and health. The model has various limitations including those of the reliability of its data, but it is sufficiently precise for its main function of clarifying the choices facing policymakers. 6

  17. Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice.

    Science.gov (United States)

    Petkau, Terri L; Blanco, Jake; Leavitt, Blair R

    2017-10-01

    Progranulin deficiency due to heterozygous null mutations in the GRN gene is a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous loss-of-function GRN mutations cause neuronal ceroid lipofuscinosis (NCL). Aged progranulin-knockout mice display highly exaggerated lipofuscinosis, microgliosis, and astrogliosis, as well as mild cell loss in specific brain regions. Progranulin is a secreted glycoprotein expressed in both neurons and microglia, but not astrocytes, in the brain. We generated conditional progranulin-knockout mice that lack progranulin in nestin-expressing cells (Nes-cKO mice), which include most neurons as well as astrocytes. We confirmed near complete knockout of progranulin in neurons in Nes-cKO mice, while microglial progranulin levels remained similar to that of wild-type animals. Overall brain progranulin levels were reduced by about 50% in Nes-cKO, and no Grn was detected in primary Nes-cKO neurons. Nes-cKO mice aged to 12months did not display any increase in lipofuscin deposition, microgliosis, or astrogliosis in the four brain regions examined, though increases were observed for most of these measures in Grn-null animals. We conclude that neuron-specific loss of progranulin is not sufficient to cause similar neuropathological changes to those seen in constitutive Grn-null animals. Our results suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. REACH MUSC: A Telemedicine Facilitated Network for Stroke: Initial Operational Experience

    Science.gov (United States)

    Adams, Robert J.; Debenham, Ellen; Chalela, Julio; Chimowitz, Marc; Hays, Angela; Hill, Cody; Holmstedt, Christine; Jauch, Edward; Kitch, Alec; Lazaridis, Christos; Turan, Tanya N.

    2012-01-01

    REACH Medical University of South Carolina (MUSC) provides stroke consults via the internet in South Carolina. From May 2008 to April 2011 231 patients were treated with intravenous (IV) thrombolysis and 369 were transferred to MUSC including 42 for intra-arterial revascularization [with or without IV tissue plasminogen activator (tPA)]. Medical outcomes and hemorrhage rates, reported elsewhere, were good (Lazaridis et al., 2011). Here we report operational features of REACH MUSC which covers 15 sites with 2,482 beds and 471,875 Emergency Department (ED) visits per year. Eight Academic Faculty from MUSC worked with 165 different physicians and 325 different nurses in the conduct of 1085 consults. For the 231 who received tPA, time milestones (in minutes) were: Onset to Door: 62 (mean), 50 (median); Door to REACH Consult: 43 and 33, Consult Request to Consult Start: was 9 and 7, Consult Start to tPA Decision: 31 and 25; Decision to Infusion: 20 and 14, and total Door to Needle: 98 and 87. The comparable times for the 854 not receiving tPA were: Onset to Door: 140 and 75; Door to REACH Consult: 61 and 41; Consult Request to Consult Start: 9 and 7, Consult Start to tPA Decision: 27 and 23. While the consultants respond to consult requests in <10, there is a long delay between arrival and Consult request. Tracking of operations indicates if we target shortening Door to Call time and time from tPA decision to start of drug infusion we may be able to improve Door to Needle times to target of <60. The large number of individuals involved in the care of these patients, most of whom had no training in REACH usage, will require novel approaches to staff education in ED based operations where turnover is high. Despite these challenges, this robust system delivered tPA safely and in a high fraction of patients evaluated using the REACH MUSC system. PMID:22435064

  19. REACH MUSC: A telemedicine facilitated network for urgent stroke: initial experience

    Directory of Open Access Journals (Sweden)

    Robert J. Adams

    2012-03-01

    Full Text Available REACH MUSC provides stroke consults via the internet in South Carolina. From May 2008 to April 2011 231 patients were treated with intravenous (IV thrombolysis and 369 were transferred to Medical University of South Carolina (MUSC including 42 for intra-arterial revascularization (with or without IV tPA. Medical outcomes and hemorrhage rates, reported elsewhere, were good (Lazaridis et al. 2011, in press. Here we report operational features of REACH MUSC which covers 15 sites with 2,482 beds and 471,875 Emergency Department (ED visits per year. Eight Academic Faculty from MUSC worked with 165 different physicians and 325 different nurses in the conduct of 1085 consults. For the 231 who received tissue plasminogen activator (tPA, time milestones were: Onset to Door: 62 min (mean, 50 (median; Door to REACH Consult: 43 and 33, Consult Request to Consult Start: was 9 and 7 minutes, Consult Start to tPA Decision: 31 and 25 minutes; Decision to Infusion: 20 and 14 minutes, and total Door to Needle: 98 and 87 minutes. The comparable times for the 854 not receiving tPA were: Onset to Door: 140 and 75 minutes; Door to REACH Consult: 61 and 41 minutes; Consult Request to Consult Start 9 and 7 minutes, Consult Start to tPA Decision 27 and 23 minutes. While the consultants respond to consult requests in < 10 minutes, there is a long delay between arrival and Consult request. Tracking of operations indicates if we target shortening Door to Call time and time from tPA decision to start of drug infusion we may be able to improve Door to Needle times to target of < 60 minutes. The large number of individuals involved in the care of these patients, most of whom had no training in REACH usage,will require novel approaches to staff education in ED based operations where turnover is high. Despite these challenges this robust system delivered tPA safely and in a high fraction of patients evaluated using the REACH MUSC system.

  20. Goodbye to Universal Development and Call for Diversified, Democratic Sufficiency and Frugality

    DEFF Research Database (Denmark)

    Buch-Hansen, Mogens

    2012-01-01

    for development within a finite ecological planet calls for radical new thinking about development in terms of sufficiency, frugality and sustainability. The interdisciplinary approach of development studies can play a pertinent role in the necessary redefinition of development in rich and poor countries. This...... World countries materialistic welfare similarly to the developed countries, the poorest countries keep falling further behind in poverty. Rapidly growing emerging economies, however, that all together contain more than half of the world population, now adds up to existing mass consumerism and demand...... changing the established North-South hegemonic world order based in the linear concept of development. This creates two new scenarios. One is the rapidly growing challenges to the global ecosystems, including greenhouse gasses in the atmosphere that with the expected global population by the middle...